# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Aldo_ket_red PF00248.16 EFE37181.1 - 2.5e-48 164.3 0.0 2.9e-48 164.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family UPF0061 PF02696.9 EFE37183.1 - 2e-87 293.5 0.0 5.5e-72 242.6 0.0 2.0 1 1 1 2 2 2 2 Uncharacterized ACR, YdiU/UPF0061 family DUF3296 PF11726.3 EFE37183.1 - 0.012 15.1 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3296) zf-C2H2 PF00096.21 EFE37186.1 - 2.4e-10 40.1 11.2 1.1e-05 25.4 3.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE37186.1 - 1.3e-07 31.4 8.0 0.00012 22.1 1.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFE37186.1 - 2.9e-07 30.4 30.0 4.7e-06 26.6 0.2 4.1 4 1 0 4 4 3 3 Zinc-finger double domain zf-met PF12874.2 EFE37186.1 - 2.2e-06 27.6 2.9 2.1e-05 24.5 0.9 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EFE37186.1 - 3e-05 24.0 6.6 0.00011 22.1 1.5 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFE37186.1 - 0.00038 20.2 7.3 0.008 16.0 1.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.1 EFE37186.1 - 0.14 11.8 4.0 6.2 6.5 0.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Zip PF02535.17 EFE37186.1 - 0.16 10.9 2.3 0.22 10.4 1.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter APC_CDC26 PF10471.4 EFE37186.1 - 0.33 11.7 13.4 0.84 10.4 9.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 zf-BED PF02892.10 EFE37186.1 - 0.38 10.5 5.5 0.11 12.3 0.6 2.1 2 0 0 2 2 2 0 BED zinc finger NinG PF05766.7 EFE37186.1 - 0.53 9.9 7.6 3.1 7.5 0.7 2.3 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein Suf PF05843.9 EFE37186.1 - 2.2 7.9 7.3 0.65 9.6 3.3 1.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4175 PF13779.1 EFE37186.1 - 3.4 5.2 11.4 4.3 4.9 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DsbC PF11412.3 EFE37187.1 - 0.0053 16.5 0.0 0.0053 16.5 0.0 1.2 1 0 0 1 1 1 1 Disulphide bond corrector protein DsbC GST_N_3 PF13417.1 EFE37189.1 - 0.00017 21.7 0.0 0.00034 20.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE37189.1 - 0.0017 18.1 0.4 0.31 10.9 0.0 2.9 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFE37189.1 - 0.0019 18.1 0.1 0.061 13.3 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain MIP-T3 PF10243.4 EFE37190.1 - 0.0099 14.4 15.3 0.011 14.2 10.6 1.0 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Cwf_Cwc_15 PF04889.7 EFE37190.1 - 0.11 12.1 21.9 0.19 11.4 15.2 1.3 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DDHD PF02862.12 EFE37190.1 - 0.4 10.4 2.2 0.48 10.1 1.6 1.2 1 0 0 1 1 1 0 DDHD domain DUF2457 PF10446.4 EFE37190.1 - 5.8 5.5 32.6 0.31 9.6 10.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Ins_P5_2-kin PF06090.7 EFE37191.1 - 2e-62 211.0 0.0 2.4e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF4444 PF14563.1 EFE37191.1 - 0.028 13.7 0.3 0.092 12.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4444) Sec15 PF04091.7 EFE37192.1 - 8.9e-104 347.1 10.6 4e-103 344.9 0.3 3.7 4 1 0 4 4 4 1 Exocyst complex subunit Sec15-like COG2 PF06148.6 EFE37192.1 - 0.00088 19.1 5.0 0.00088 19.1 3.4 2.2 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF2450 PF10475.4 EFE37192.1 - 0.0031 16.4 5.4 0.0082 15.0 3.7 1.7 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Sec5 PF15469.1 EFE37192.1 - 0.0057 16.4 7.5 0.016 14.9 1.7 3.3 3 0 0 3 3 3 1 Exocyst complex component Sec5 PMEI PF04043.10 EFE37192.1 - 0.13 12.1 1.8 0.19 11.6 0.4 1.8 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Sec8_exocyst PF04048.9 EFE37192.1 - 0.6 9.7 11.1 0.04 13.5 3.1 2.5 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain CBFD_NFYB_HMF PF00808.18 EFE37193.1 - 2.2e-19 69.2 0.5 3.9e-19 68.4 0.3 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFE37193.1 - 3.3e-13 49.5 0.1 4.9e-13 48.9 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 EFE37193.1 - 0.01 15.6 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Totivirus_coat PF05518.6 EFE37193.1 - 0.19 9.5 5.5 0.23 9.2 3.8 1.1 1 0 0 1 1 1 0 Totivirus coat protein PAT1 PF09770.4 EFE37193.1 - 7.6 4.6 11.2 9.4 4.3 7.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tubulin_C PF03953.12 EFE37194.1 - 6.4e-48 161.9 0.1 8.4e-48 161.5 0.1 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain EF-hand_4 PF12763.2 EFE37195.1 - 7.3e-20 70.6 0.0 1.1e-15 57.2 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 EFE37195.1 - 8.4e-07 29.0 0.1 3.3e-06 27.1 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 EFE37195.1 - 2.7e-05 23.1 1.7 0.015 14.5 0.0 4.0 4 0 0 4 4 4 1 EF hand UBA PF00627.26 EFE37195.1 - 0.00022 20.9 0.0 0.00043 20.0 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain DUF812 PF05667.6 EFE37195.1 - 0.0004 19.0 15.0 0.00078 18.0 10.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF812) EF-hand_8 PF13833.1 EFE37195.1 - 0.0019 17.7 0.4 0.017 14.7 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair Fib_alpha PF08702.5 EFE37195.1 - 0.0045 17.1 9.0 0.0045 17.1 6.2 2.3 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family APG6 PF04111.7 EFE37195.1 - 0.0047 16.0 19.7 0.0047 16.0 13.7 2.1 1 1 1 2 2 2 1 Autophagy protein Apg6 EF-hand_6 PF13405.1 EFE37195.1 - 0.047 13.5 2.9 13 6.0 0.0 3.9 4 0 0 4 4 3 0 EF-hand domain GAS PF13851.1 EFE37195.1 - 0.074 12.2 33.1 0.68 9.0 12.4 3.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.3 EFE37195.1 - 0.35 8.1 29.9 0.5 7.6 20.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MbeD_MobD PF04899.7 EFE37195.1 - 0.36 10.7 17.7 1.7 8.5 0.7 4.3 3 1 1 4 4 4 0 MbeD/MobD like CENP-F_leu_zip PF10473.4 EFE37195.1 - 0.76 9.6 32.4 0.12 12.2 8.5 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_tail_1 PF01576.14 EFE37195.1 - 0.98 7.0 34.5 1.4 6.5 10.3 1.9 1 1 1 2 2 2 0 Myosin tail TPR_MLP1_2 PF07926.7 EFE37195.1 - 2.2 8.0 35.4 1.7 8.4 15.7 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IFT57 PF10498.4 EFE37195.1 - 2.4 6.8 21.9 4.4 5.9 15.2 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Reo_sigmaC PF04582.7 EFE37195.1 - 3 6.9 7.5 0.93 8.6 1.4 2.0 1 1 0 1 1 1 0 Reovirus sigma C capsid protein CALCOCO1 PF07888.6 EFE37195.1 - 4.7 5.3 22.1 7.1 4.8 15.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like FUSC PF04632.7 EFE37195.1 - 8.7 4.6 8.8 16 3.7 6.1 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fmp27_WPPW PF10359.4 EFE37195.1 - 9.2 4.5 20.9 0.4 9.0 2.6 2.8 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain MARVEL PF01284.18 EFE37196.1 - 2.7e-15 56.4 16.1 8.4e-15 54.8 11.2 1.6 1 1 0 1 1 1 1 Membrane-associating domain Oleosin PF01277.12 EFE37196.1 - 2.9 7.4 5.9 1.1 8.8 1.7 2.1 2 1 0 2 2 2 0 Oleosin Cys_Met_Meta_PP PF01053.15 EFE37197.1 - 4.2e-124 413.7 0.0 5.2e-124 413.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EFE37197.1 - 5.1e-13 48.7 1.0 6.2e-13 48.5 0.1 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 EFE37197.1 - 4.1e-06 26.1 0.0 5.8e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EFE37197.1 - 3.8e-05 22.8 0.0 6.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFE37197.1 - 0.028 13.1 0.1 0.072 11.8 0.1 1.7 1 1 0 1 1 1 0 Aminotransferase class-V AMP-binding PF00501.23 EFE37198.1 - 7.2e-75 251.9 0.0 9.1e-75 251.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF2012 PF09430.5 EFE37199.1 - 3.8e-25 88.1 0.0 5.4e-25 87.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) LCCL PF03815.14 EFE37200.1 - 2.1e-18 66.0 0.1 3.6e-18 65.3 0.1 1.3 1 0 0 1 1 1 1 LCCL domain PBP1_TM PF14812.1 EFE37200.1 - 3.7 7.9 4.9 2.9 8.2 1.1 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3328 PF11807.3 EFE37201.1 - 0.0033 17.1 3.9 0.82 9.3 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3328) DUF3328 PF11807.3 EFE37203.1 - 2.1e-06 27.6 0.0 2.3e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ank_2 PF12796.2 EFE37204.1 - 2.7e-38 130.1 2.3 4.6e-26 90.9 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFE37204.1 - 6.7e-30 101.3 0.6 9.7e-09 34.6 0.2 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 EFE37204.1 - 2.7e-28 97.8 0.9 1.4e-14 54.1 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE37204.1 - 1.6e-25 88.5 0.4 5.9e-10 39.0 0.0 3.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE37204.1 - 6.4e-23 78.5 0.1 2.7e-07 30.1 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat bZIP_Maf PF03131.12 EFE37204.1 - 0.038 14.2 6.3 0.064 13.5 4.4 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_1 PF00170.16 EFE37204.1 - 0.073 13.0 9.8 0.13 12.2 6.8 1.3 1 0 0 1 1 1 0 bZIP transcription factor PTR2 PF00854.16 EFE37205.1 - 1.2e-40 139.4 9.2 1.3e-39 136.0 6.4 2.1 1 1 0 1 1 1 1 POT family TPD52 PF04201.10 EFE37205.1 - 0.17 11.6 0.2 0.3 10.7 0.1 1.3 1 0 0 1 1 1 0 Tumour protein D52 family Methyltransf_32 PF13679.1 EFE37206.1 - 3.9e-19 68.7 1.5 8.5e-19 67.6 1.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.6 EFE37207.1 - 4.2e-18 65.5 3.6 9.4e-18 64.4 0.0 2.7 3 0 0 3 3 3 1 Syntaxin 6, N-terminal SNARE PF05739.14 EFE37207.1 - 1.1e-11 44.2 3.6 1.1e-11 44.2 2.5 2.7 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.1 EFE37207.1 - 0.073 13.1 0.3 0.41 10.6 0.0 2.4 2 1 0 2 2 2 0 Syntaxin-like protein PilJ PF13675.1 EFE37207.1 - 0.11 12.8 2.2 0.33 11.2 0.1 2.2 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Vps51 PF08700.6 EFE37207.1 - 0.14 12.0 4.6 9.7 6.1 0.0 3.2 3 0 0 3 3 3 0 Vps51/Vps67 Reo_sigmaC PF04582.7 EFE37207.1 - 0.15 11.2 0.3 0.93 8.6 0.0 2.0 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF3618 PF12277.3 EFE37207.1 - 0.19 11.7 8.3 1.1 9.3 0.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3618) Laminin_II PF06009.7 EFE37207.1 - 0.23 11.1 1.4 5.4 6.7 0.1 2.6 2 1 1 3 3 3 0 Laminin Domain II Med30 PF11315.3 EFE37207.1 - 0.26 11.3 2.5 18 5.4 0.1 3.0 3 0 0 3 3 3 0 Mediator complex subunit 30 DUF883 PF05957.8 EFE37207.1 - 0.41 11.0 4.8 15 6.0 0.0 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) TBPIP PF07106.8 EFE37207.1 - 0.69 9.4 0.0 0.69 9.4 0.0 2.6 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) NPV_P10 PF05531.7 EFE37207.1 - 1.8 8.8 5.3 7.5 6.8 0.5 2.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein IncA PF04156.9 EFE37207.1 - 4.8 6.7 10.0 0.45 10.0 0.2 2.3 2 1 0 2 2 2 0 IncA protein NAP PF00956.13 EFE37208.1 - 9.7e-34 116.5 1.7 2.4e-33 115.3 1.2 1.6 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) NmrA PF05368.8 EFE37209.1 - 7.2e-56 189.0 0.0 9.3e-56 188.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFE37209.1 - 4e-06 26.9 0.0 5.6e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding DUF1876 PF08962.6 EFE37209.1 - 0.036 13.8 0.2 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1876) Asparaginase PF00710.15 EFE37210.1 - 1.8e-105 352.3 0.0 2.2e-105 352.0 0.0 1.1 1 0 0 1 1 1 1 Asparaginase Ank_2 PF12796.2 EFE37210.1 - 1.2e-13 51.1 0.1 2.2e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFE37210.1 - 1.4e-12 46.6 1.9 1.9e-06 27.3 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 EFE37210.1 - 5.1e-09 36.4 1.6 1.8e-05 25.1 0.1 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE37210.1 - 7.7e-08 32.3 0.3 6.5e-07 29.3 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE37210.1 - 1.4e-06 27.9 0.8 0.021 15.0 0.0 4.2 5 0 0 5 5 5 2 Ankyrin repeat MTTB PF06253.6 EFE37210.1 - 0.017 12.9 0.2 0.025 12.3 0.1 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Peptidase_S8 PF00082.17 EFE37211.1 - 1.4e-42 145.8 0.4 2.3e-42 145.0 0.3 1.4 1 0 0 1 1 1 1 Subtilase family APH PF01636.18 EFE37213.1 - 1.5e-16 60.8 0.0 3.2e-15 56.5 0.0 2.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE37213.1 - 0.0012 17.5 0.0 0.89 8.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) APH PF01636.18 EFE37215.1 - 2.6e-11 43.7 0.0 6.3e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE37215.1 - 8.9e-06 25.4 0.0 1.3e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.20 EFE37215.1 - 0.00068 18.8 0.0 0.22 10.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Fructosamin_kin PF03881.9 EFE37215.1 - 0.036 13.0 0.0 5.3 5.9 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase CBM_19 PF03427.8 EFE37215.1 - 0.06 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) AA_permease_2 PF13520.1 EFE37216.1 - 7.3e-68 229.0 38.4 9.3e-68 228.7 26.6 1.2 1 0 0 1 1 1 1 Amino acid permease DAP10 PF07213.6 EFE37216.1 - 0.057 13.1 1.4 1.3 8.8 0.3 2.6 2 0 0 2 2 2 0 DAP10 membrane protein adh_short PF00106.20 EFE37217.1 - 3.1e-23 82.5 0.0 4.2e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE37217.1 - 6.9e-11 42.3 0.0 8.9e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE37217.1 - 2.7e-06 27.1 0.0 3.9e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.13 EFE37217.1 - 0.0012 18.7 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_10 PF13460.1 EFE37217.1 - 0.038 13.9 0.0 0.053 13.5 0.0 1.3 1 1 0 1 1 1 0 NADH(P)-binding Epimerase PF01370.16 EFE37217.1 - 0.042 13.2 0.0 0.13 11.6 0.0 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family CBFD_NFYB_HMF PF00808.18 EFE37218.1 - 7.4e-18 64.3 0.2 7.4e-18 64.3 0.2 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFE37218.1 - 0.0062 16.6 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 EFE37218.1 - 0.071 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated YolD PF08863.5 EFE37218.1 - 0.52 10.2 2.8 0.38 10.6 0.8 1.6 2 0 0 2 2 2 0 YolD-like protein Actin PF00022.14 EFE37219.1 - 8e-22 77.1 0.0 7.9e-20 70.6 0.0 2.8 2 1 0 2 2 2 2 Actin Methyltransf_32 PF13679.1 EFE37219.1 - 0.048 13.3 1.2 6.2 6.5 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain Bystin PF05291.6 EFE37220.1 - 9.8e-126 418.7 0.0 1.4e-125 418.1 0.0 1.2 1 0 0 1 1 1 1 Bystin SPRY PF00622.23 EFE37221.1 - 0.00051 20.1 0.0 0.0035 17.4 0.0 2.3 3 0 0 3 3 3 1 SPRY domain Amidase PF01425.16 EFE37222.1 - 4.1e-100 335.7 4.8 3.4e-59 200.8 3.7 2.1 2 0 0 2 2 2 2 Amidase Snf7 PF03357.16 EFE37223.1 - 0.00029 20.2 8.1 0.00038 19.8 5.6 1.1 1 0 0 1 1 1 1 Snf7 DUF3829 PF12889.2 EFE37223.1 - 0.01 15.0 5.4 0.014 14.6 3.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3829) DUF4169 PF13770.1 EFE37223.1 - 0.25 11.3 6.8 0.12 12.3 2.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4169) bZIP_2 PF07716.10 EFE37225.1 - 1.5e-08 34.3 14.6 1.5e-08 34.3 10.1 2.7 2 1 1 3 3 3 2 Basic region leucine zipper bZIP_1 PF00170.16 EFE37225.1 - 2.8e-05 23.9 17.4 0.00016 21.5 12.1 2.2 1 1 0 1 1 1 1 bZIP transcription factor Striatin PF08232.7 EFE37225.1 - 0.00021 21.6 6.7 0.00021 21.6 4.7 1.7 1 1 1 2 2 2 1 Striatin family bZIP_Maf PF03131.12 EFE37225.1 - 0.0031 17.7 11.9 0.006 16.8 8.3 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF869 PF05911.6 EFE37225.1 - 0.0065 14.7 5.5 0.0096 14.2 3.8 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) CENP-H PF05837.7 EFE37225.1 - 0.012 15.7 2.1 0.012 15.7 1.4 2.2 1 1 0 2 2 2 0 Centromere protein H (CENP-H) Mito_fiss_reg PF05308.6 EFE37225.1 - 0.09 12.1 12.7 0.19 11.0 8.8 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator APG6 PF04111.7 EFE37225.1 - 0.12 11.3 8.7 0.18 10.8 6.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 HAUS-augmin3 PF14932.1 EFE37225.1 - 0.44 9.6 7.5 0.7 9.0 5.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Mucin PF01456.12 EFE37225.1 - 0.51 10.1 17.7 1 9.1 12.2 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF724 PF05266.9 EFE37225.1 - 0.52 9.8 6.4 0.86 9.1 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) APH PF01636.18 EFE37226.1 - 2.9e-09 37.0 0.0 8.2e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE37226.1 - 0.00078 18.1 0.1 0.024 13.2 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.9 EFE37226.1 - 0.012 14.5 0.0 0.46 9.4 0.0 2.2 2 0 0 2 2 2 0 Fructosamine kinase Choline_kinase PF01633.15 EFE37226.1 - 0.081 12.4 0.0 3.4 7.2 0.0 2.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase ADH_zinc_N PF00107.21 EFE37227.1 - 5.5e-11 42.1 0.0 4.2e-10 39.2 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.20 EFE37227.1 - 0.0034 17.3 0.2 0.0066 16.3 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE37227.1 - 0.0042 16.7 0.1 0.0076 15.9 0.1 1.4 1 0 0 1 1 1 1 KR domain ADH_N PF08240.7 EFE37227.1 - 0.0088 15.8 0.0 0.024 14.4 0.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Eno-Rase_NADH_b PF12242.3 EFE37227.1 - 0.053 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase T2SL PF05134.8 EFE37227.1 - 0.15 11.2 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein L Metallophos PF00149.23 EFE37228.1 - 1.5e-08 34.2 0.0 2.6e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.13 EFE37228.1 - 0.01 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain TetM_leader PF08076.6 EFE37228.1 - 0.072 12.6 1.2 0.24 10.9 0.8 1.9 1 0 0 1 1 1 0 Tetracycline resistance determinant leader peptide Transket_pyr PF02779.19 EFE37229.1 - 1.9e-47 161.0 0.0 3.5e-47 160.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EFE37229.1 - 2e-35 121.4 0.1 5.8e-35 119.9 0.1 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain Glyco_hydro_43 PF04616.9 EFE37230.1 - 4.2e-50 170.4 3.8 1.2e-49 168.8 2.6 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 zf-C2H2 PF00096.21 EFE37231.1 - 0.0054 17.0 1.2 0.011 15.9 0.8 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.2 EFE37231.1 - 0.0069 16.5 0.3 0.012 15.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EFE37231.1 - 0.012 15.9 0.4 0.026 14.8 0.2 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE37231.1 - 0.056 13.5 2.7 0.092 12.9 1.9 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EFE37231.1 - 0.11 12.6 0.2 0.16 12.1 0.2 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.1 EFE37231.1 - 0.11 12.4 0.2 0.11 12.4 0.1 1.6 2 0 0 2 2 2 0 C2H2-type zinc finger DUF1691 PF07950.6 EFE37232.1 - 7.1e-47 157.8 5.4 8.9e-32 109.2 2.6 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) DUF1469 PF07332.6 EFE37232.1 - 8 6.2 8.2 0.95 9.2 1.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1469) WD40 PF00400.27 EFE37233.1 - 6.9e-37 124.0 12.2 1.8e-09 37.1 0.3 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat EF-hand_1 PF00036.27 EFE37234.1 - 3.5e-13 47.8 5.2 1.3e-06 27.2 0.3 3.1 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 EFE37234.1 - 8.2e-12 45.0 2.7 2.1e-11 43.8 1.4 2.1 2 0 0 2 2 2 1 EF-hand domain pair ZZ PF00569.12 EFE37234.1 - 2e-11 43.2 4.4 3.6e-11 42.4 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_6 PF13405.1 EFE37234.1 - 8.5e-10 37.6 4.3 0.00039 20.0 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 EFE37234.1 - 1e-06 28.2 6.6 0.0014 18.2 0.3 3.7 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.1 EFE37234.1 - 4.8e-06 25.6 4.7 0.005 16.1 0.2 2.8 3 0 0 3 3 3 2 EF hand C1_3 PF07649.7 EFE37234.1 - 1.3 9.0 6.3 2.5 8.2 4.4 1.5 1 0 0 1 1 1 0 C1-like domain MFS_1 PF07690.11 EFE37235.1 - 2.1e-24 85.9 59.7 3.7e-23 81.8 26.3 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Acyl_transf_3 PF01757.17 EFE37235.1 - 0.097 11.4 24.3 0.019 13.8 4.0 2.2 1 1 1 2 2 2 0 Acyltransferase family DUF3237 PF11578.3 EFE37236.1 - 5.2e-33 113.4 0.0 7.1e-33 113.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) zf-BED PF02892.10 EFE37236.1 - 0.059 13.1 1.0 0.11 12.3 0.7 1.3 1 0 0 1 1 1 0 BED zinc finger Gln-synt_C PF00120.19 EFE37237.1 - 7.7e-32 110.4 0.0 1e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain adh_short PF00106.20 EFE37239.1 - 5e-29 101.3 1.0 6.9e-29 100.9 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE37239.1 - 1.1e-17 64.6 0.0 1.4e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE37239.1 - 1.5e-11 44.2 0.7 2.6e-11 43.5 0.5 1.3 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 EFE37239.1 - 9.4e-05 22.1 0.2 0.00018 21.2 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 EFE37239.1 - 0.0011 18.4 0.1 0.0018 17.7 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_18 PF12847.2 EFE37239.1 - 0.0091 16.5 0.0 0.061 13.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Polysacc_synt_2 PF02719.10 EFE37239.1 - 0.017 14.0 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 EFE37239.1 - 0.044 13.5 2.7 0.45 10.3 0.3 2.5 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 EFE37239.1 - 0.054 13.5 1.6 0.13 12.2 0.8 1.9 1 1 0 1 1 1 0 NADH(P)-binding Saccharop_dh PF03435.13 EFE37239.1 - 0.062 12.2 0.2 0.093 11.6 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase THF_DHG_CYH_C PF02882.14 EFE37239.1 - 0.071 12.1 0.7 0.13 11.3 0.1 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_N PF00056.18 EFE37239.1 - 0.089 12.6 1.0 0.35 10.6 0.4 2.0 1 1 1 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain BTB PF00651.26 EFE37240.1 - 0.00026 20.9 0.0 0.0041 17.0 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Glyco_hydro_76 PF03663.9 EFE37241.1 - 7.2e-149 496.1 14.9 9e-149 495.8 10.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 EFE37241.1 - 0.00057 19.0 6.0 0.013 14.6 0.1 3.1 2 1 0 3 3 3 2 Glycosyl Hydrolase Family 88 CBS PF00571.23 EFE37242.1 - 1.4e-41 139.9 6.7 1.1e-10 41.1 0.0 5.3 5 0 0 5 5 5 4 CBS domain PB1 PF00564.19 EFE37242.1 - 2.3e-10 40.0 0.0 9.8e-10 37.9 0.0 2.1 2 0 0 2 2 2 1 PB1 domain CW_binding_2 PF04122.7 EFE37242.1 - 0.083 13.1 0.7 0.41 10.8 0.1 2.4 2 1 0 2 2 2 0 Putative cell wall binding repeat 2 DUF3235 PF11574.3 EFE37242.1 - 0.12 12.6 1.9 1.4 9.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) Ribosomal_S26e PF01283.14 EFE37243.1 - 1.2e-44 151.2 14.4 2.9e-43 146.7 4.8 2.0 1 1 1 2 2 2 2 Ribosomal protein S26e Zn_ribbon_2 PF12674.2 EFE37243.1 - 0.02 15.2 0.2 8.7 6.7 0.0 2.4 1 1 1 2 2 2 0 Putative zinc ribbon domain LRR_4 PF12799.2 EFE37244.1 - 0.0051 16.4 7.8 4.3 7.0 0.0 5.0 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) F-box-like PF12937.2 EFE37244.1 - 0.006 16.2 0.2 0.018 14.7 0.1 1.8 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.1 EFE37244.1 - 0.04 13.9 8.0 26 5.3 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.28 EFE37244.1 - 1.1 9.5 11.9 19 5.8 0.0 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 EFE37244.1 - 6.4 7.4 11.9 1.3e+02 3.5 0.1 5.8 6 0 0 6 6 6 0 Leucine rich repeat Sulfotransfer_3 PF13469.1 EFE37245.1 - 0.016 16.1 0.3 0.043 14.7 0.2 1.7 1 1 0 1 1 1 0 Sulfotransferase family Peptidase_C14 PF00656.17 EFE37246.1 - 1.8e-68 230.9 0.0 2.2e-68 230.6 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DUF605 PF04652.11 EFE37246.1 - 8.2 5.7 17.9 12 5.1 12.4 1.2 1 0 0 1 1 1 0 Vta1 like DUF3099 PF11298.3 EFE37247.1 - 0.085 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) DUF4131 PF13567.1 EFE37247.1 - 1.8 7.9 5.9 2.7 7.3 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Cpn60_TCP1 PF00118.19 EFE37248.1 - 2.3e-65 221.1 0.0 2.9e-65 220.7 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ELFV_dehydrog PF00208.16 EFE37250.1 - 2.8e-80 269.4 0.8 3.4e-80 269.1 0.5 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 EFE37250.1 - 4.1e-28 97.5 0.0 1.1e-26 92.8 0.0 2.4 1 1 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DPBB_1 PF03330.13 EFE37251.1 - 0.025 14.5 0.1 0.063 13.2 0.0 1.7 1 0 0 1 1 1 0 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Prp19_bind PF06991.6 EFE37253.1 - 4.5e-45 154.0 21.6 4.5e-45 154.0 14.9 2.4 2 1 0 2 2 2 1 Splicing factor, Prp19-binding domain DUF501 PF04417.7 EFE37253.1 - 9.7 6.0 7.1 23 4.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF501) Glyco_hydro_16 PF00722.16 EFE37254.1 - 1.1e-44 151.9 2.0 1.7e-44 151.3 1.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF1191 PF06697.7 EFE37254.1 - 0.055 12.2 0.0 0.077 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) GATA PF00320.22 EFE37255.1 - 1.5e-05 24.2 4.7 0.00059 19.1 0.5 2.6 2 0 0 2 2 2 2 GATA zinc finger LSM PF01423.17 EFE37256.1 - 6.7e-13 47.9 0.1 8.8e-13 47.5 0.0 1.2 1 0 0 1 1 1 1 LSM domain CAV_VP3 PF04771.7 EFE37256.1 - 0.11 12.4 0.0 3.6 7.5 0.0 2.0 1 1 1 2 2 2 0 Chicken anaemia virus VP-3 protein Dak1 PF02733.12 EFE37257.1 - 3.6e-115 383.9 2.0 5e-115 383.5 1.4 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 EFE37257.1 - 7.4e-46 156.0 1.2 3.2e-45 153.9 0.2 2.1 2 0 0 2 2 2 1 DAK2 domain Cullin PF00888.17 EFE37258.1 - 2.5e-124 415.9 5.0 3.2e-124 415.6 3.5 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 EFE37258.1 - 1.2e-17 63.4 0.6 3.3e-17 62.0 0.4 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain HbrB PF08539.6 EFE37258.1 - 0.00017 21.4 0.0 0.00041 20.2 0.0 1.6 1 0 0 1 1 1 1 HbrB-like DUF3414 PF11894.3 EFE37259.1 - 0 1319.6 25.7 0 1319.2 17.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) PI3_PI4_kinase PF00454.22 EFE37260.1 - 5.2e-44 150.4 0.1 1.6e-43 148.9 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.3 EFE37260.1 - 5.1e-36 123.7 0.0 1.6e-35 122.1 0.0 2.0 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair FATC PF02260.15 EFE37260.1 - 3.9e-12 45.3 0.8 8.3e-12 44.3 0.1 2.0 2 0 0 2 2 2 1 FATC domain DUF1353 PF07087.6 EFE37260.1 - 0.0069 15.8 0.0 0.02 14.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1353) UPF0052 PF01933.13 EFE37261.1 - 1.3e-47 162.5 0.0 1.8e-47 162.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 zf-C3HC4_3 PF13920.1 EFE37262.1 - 0.0016 18.0 3.3 0.56 9.9 0.0 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE37262.1 - 0.015 15.1 2.2 0.032 14.0 1.5 1.6 1 1 0 1 1 1 0 Ring finger domain DUF2367 PF10164.4 EFE37262.1 - 0.023 14.5 1.7 0.098 12.5 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2367) RNHCP PF12647.2 EFE37262.1 - 0.026 14.3 0.2 0.56 10.0 0.0 2.3 2 0 0 2 2 2 0 RNHCP domain DUF1644 PF07800.7 EFE37262.1 - 0.065 13.0 2.7 0.41 10.4 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Rad50_zn_hook PF04423.9 EFE37262.1 - 0.084 12.3 0.8 3.4 7.2 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_2 PF13923.1 EFE37262.1 - 0.26 11.3 4.4 1.2 9.1 1.5 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFE37262.1 - 5 7.0 6.4 4.6 7.2 2.0 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DNA_pol_A PF00476.15 EFE37263.1 - 2.7e-98 329.1 0.0 3.9e-98 328.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 EFE37263.1 - 0.0059 16.1 0.1 0.34 10.3 0.1 2.5 1 1 0 1 1 1 1 3'-5' exonuclease CorA PF01544.13 EFE37264.1 - 4.4e-09 35.7 0.1 0.014 14.3 0.0 3.1 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein SQS_PSY PF00494.14 EFE37265.1 - 1.6e-39 135.8 0.0 2.9e-39 134.9 0.0 1.4 1 1 0 1 1 1 1 Squalene/phytoene synthase Soyouz_module PF14313.1 EFE37265.1 - 0.027 14.0 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) SNF2_N PF00176.18 EFE37266.1 - 8.1e-70 234.9 0.0 1.1e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 EFE37266.1 - 5.1e-23 81.0 0.0 9.9e-23 80.1 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.26 EFE37266.1 - 6.2e-13 48.4 0.0 1.4e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 EFE37266.1 - 4.1e-06 26.6 12.9 9.2e-06 25.5 8.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE37266.1 - 0.00019 21.0 9.8 0.00036 20.1 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE37266.1 - 0.0011 18.6 10.9 0.003 17.3 7.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFE37266.1 - 0.0015 18.1 12.6 0.0033 17.0 8.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE37266.1 - 0.018 14.7 11.0 0.04 13.6 7.6 1.6 1 0 0 1 1 1 0 zinc-RING finger domain UBA_4 PF14555.1 EFE37266.1 - 0.036 13.5 0.0 0.11 12.0 0.0 1.9 1 0 0 1 1 1 0 UBA-like domain zf-C3HC4_4 PF15227.1 EFE37266.1 - 0.37 10.7 12.2 0.78 9.6 8.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFE37266.1 - 0.93 9.2 8.8 3.1 7.5 6.1 2.0 1 0 0 1 1 1 0 RING-type zinc-finger Lyase_1 PF00206.15 EFE37267.1 - 1.7e-16 60.3 1.1 1.6e-15 57.1 0.8 2.0 1 1 0 1 1 1 1 Lyase ADSL_C PF10397.4 EFE37267.1 - 2.9e-15 56.0 0.0 8.4e-15 54.5 0.0 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus GTP_EFTU PF00009.22 EFE37270.1 - 3.4e-22 78.7 0.1 9.4e-22 77.3 0.1 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 EFE37270.1 - 1.3e-06 28.4 1.1 3.3e-06 27.1 0.8 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 EFE37270.1 - 0.00035 20.0 0.4 0.7 9.3 0.0 3.4 2 1 1 3 3 3 2 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.18 EFE37270.1 - 0.0022 17.9 0.0 0.005 16.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE37270.1 - 0.0025 18.3 0.1 0.019 15.4 0.1 2.5 1 1 0 1 1 1 1 Miro-like protein FtsK_SpoIIIE PF01580.13 EFE37270.1 - 0.016 14.6 0.0 0.034 13.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family MobB PF03205.9 EFE37270.1 - 0.039 13.6 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Dynamin_N PF00350.18 EFE37270.1 - 0.044 13.5 2.8 0.18 11.6 0.3 2.5 2 1 0 2 2 2 0 Dynamin family AAA_10 PF12846.2 EFE37270.1 - 0.12 11.7 0.3 0.75 9.1 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain LSM PF01423.17 EFE37271.1 - 6.2e-12 44.9 0.1 9.8e-12 44.2 0.1 1.4 1 1 0 1 1 1 1 LSM domain ATP13 PF12921.2 EFE37272.1 - 8.7e-29 99.4 0.0 1.7e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR_2 PF13041.1 EFE37272.1 - 1.3e-05 25.0 1.2 0.027 14.4 0.1 3.2 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.1 EFE37272.1 - 0.00014 21.8 0.0 0.0041 17.3 0.0 3.1 3 0 0 3 3 3 1 Pentatricopeptide repeat domain FCD PF07729.7 EFE37272.1 - 0.012 15.9 0.6 0.026 14.8 0.4 1.6 1 0 0 1 1 1 0 FCD domain PPR PF01535.15 EFE37272.1 - 0.031 14.2 0.3 8.5 6.6 0.0 3.5 3 0 0 3 3 3 0 PPR repeat PIG-L PF02585.12 EFE37273.1 - 3.1e-26 92.3 0.0 5.1e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DnaJ PF00226.26 EFE37275.1 - 6.1e-19 67.5 0.1 2.8e-18 65.4 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.17 EFE37275.1 - 0.0021 17.6 0.2 0.0068 16.0 0.1 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1639 PF07797.9 EFE37276.1 - 0.13 11.6 0.5 0.45 9.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) GCV_T PF01571.16 EFE37277.1 - 3.8e-13 49.2 0.0 6.4e-13 48.5 0.0 1.4 1 1 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 EFE37277.1 - 0.00027 20.9 0.0 0.00054 19.9 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Chlamy_scaf PF09675.5 EFE37278.1 - 0.11 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) DCP2 PF05026.8 EFE37279.1 - 8.5e-37 124.9 1.7 1.5e-36 124.1 1.1 1.4 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 EFE37279.1 - 6.1e-16 58.2 0.0 1.2e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4112 PF13430.1 EFE37280.1 - 5.9e-35 119.3 0.2 7.8e-35 119.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF2392 PF10288.4 EFE37281.1 - 6.9e-25 87.4 0.0 1.1e-24 86.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) Lung_7-TM_R PF06814.8 EFE37282.1 - 3.6e-57 193.5 14.7 5e-57 193.0 10.2 1.2 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF1673 PF07895.6 EFE37282.1 - 4.9 6.6 9.8 9.1 5.7 6.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) PALP PF00291.20 EFE37283.1 - 4.5e-26 91.7 0.0 1.9e-25 89.7 0.0 1.9 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.15 EFE37283.1 - 6.7e-09 36.0 0.0 3.4e-08 33.8 0.0 2.1 2 1 0 2 2 2 1 Rhodanese-like domain MFS_1 PF07690.11 EFE37284.1 - 3.1e-43 147.8 35.8 7.6e-40 136.7 25.2 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFE37284.1 - 5.8e-17 61.1 23.0 9.3e-17 60.4 16.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE37284.1 - 6.6e-14 51.3 10.5 6.6e-14 51.3 7.2 3.7 3 1 1 4 4 4 3 Sugar (and other) transporter MMS1_N PF10433.4 EFE37285.1 - 0.00075 17.7 0.0 0.0037 15.4 0.0 2.0 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 EFE37286.1 - 4.8e-95 318.3 0.0 5.8e-95 318.0 0.0 1.1 1 0 0 1 1 1 1 CPSF A subunit region LysM PF01476.15 EFE37287.1 - 2.3e-14 53.0 0.0 9.4e-06 25.4 0.0 2.5 2 0 0 2 2 2 2 LysM domain SH3BGR PF04908.10 EFE37287.1 - 3.4 7.6 4.8 18 5.3 0.3 2.4 1 1 1 2 2 2 0 SH3-binding, glutamic acid-rich protein Ribosomal_S13 PF00416.17 EFE37289.1 - 2.2e-41 140.6 2.8 2.6e-41 140.3 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 EFE37289.1 - 0.011 14.3 0.0 0.011 14.2 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.1 EFE37289.1 - 0.067 13.2 0.3 0.3 11.1 0.0 2.1 2 1 0 2 2 2 0 Helix-hairpin-helix motif DUF1822 PF08852.6 EFE37289.1 - 0.095 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) Peptidase_S10 PF00450.17 EFE37290.1 - 5.1e-131 437.6 0.2 6.2e-131 437.3 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 EFE37290.1 - 0.0037 17.1 0.0 0.02 14.8 0.0 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Carbpep_Y_N PF05388.6 EFE37290.1 - 0.0069 16.5 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide SBDS_C PF09377.5 EFE37291.1 - 1.6e-46 157.0 0.1 2.8e-46 156.2 0.1 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.13 EFE37291.1 - 3.6e-27 93.9 0.1 6.9e-27 93.0 0.1 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein PBP1_TM PF14812.1 EFE37291.1 - 0.034 14.4 1.8 7.2 6.9 0.1 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NST1 PF13945.1 EFE37291.1 - 0.12 12.4 14.3 1.1 9.2 1.0 3.2 3 0 0 3 3 3 0 Salt tolerance down-regulator Sigma70_ner PF04546.8 EFE37291.1 - 0.39 10.3 7.1 0.75 9.3 1.4 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region BAF1_ABF1 PF04684.8 EFE37291.1 - 0.5 9.1 10.3 0.083 11.7 2.3 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor POX PF07526.6 EFE37291.1 - 0.76 10.0 6.0 5.7 7.1 0.7 2.3 2 0 0 2 2 2 0 Associated with HOX BAF1_ABF1 PF04684.8 EFE37292.1 - 0.00072 18.5 24.7 0.00072 18.5 17.1 1.7 2 0 0 2 2 2 1 BAF1 / ABF1 chromatin reorganising factor SelP_N PF04592.9 EFE37292.1 - 6.4 6.0 22.1 0.48 9.7 8.3 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF3043 PF11241.3 EFE37293.1 - 3.5 7.1 14.3 3.1 7.3 8.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) Peptidase_S8 PF00082.17 EFE37294.1 - 2.3e-20 72.8 2.4 3.6e-20 72.2 1.7 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE37294.1 - 1.6e-11 44.5 0.0 3.2e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF772 PF05598.6 EFE37294.1 - 0.0022 17.8 0.0 0.0037 17.1 0.0 1.3 1 0 0 1 1 1 1 Transposase domain (DUF772) USP7_ICP0_bdg PF12436.3 EFE37295.1 - 7.3e-39 133.4 0.0 2.2e-38 131.9 0.0 1.8 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.24 EFE37295.1 - 2.4e-25 89.1 0.5 3.8e-25 88.5 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE37295.1 - 4.9e-11 42.6 0.0 1.1e-10 41.3 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase BSD PF03909.12 EFE37296.1 - 4.9e-16 58.2 0.9 1.1e-15 57.0 0.6 1.7 1 0 0 1 1 1 1 BSD domain Suf PF05843.9 EFE37296.1 - 0.16 11.7 1.7 0.25 11.0 1.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TPR_2 PF07719.12 EFE37296.1 - 4.3 7.4 5.1 1.5 8.8 0.2 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat T2SI PF02501.12 EFE37298.1 - 0.045 13.7 2.3 0.079 12.9 1.6 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I PLAC PF08686.6 EFE37298.1 - 0.24 11.7 7.3 1.6 9.0 3.1 2.4 2 0 0 2 2 2 0 PLAC (protease and lacunin) domain WD40 PF00400.27 EFE37300.1 - 2.6e-13 49.2 7.0 0.0049 16.7 0.0 6.3 6 1 0 6 6 6 4 WD domain, G-beta repeat NACHT PF05729.7 EFE37300.1 - 0.00014 21.5 0.0 0.00028 20.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Abhydrolase_6 PF12697.2 EFE37300.1 - 0.015 15.2 0.2 0.031 14.1 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family 6PF2K PF01591.13 EFE37300.1 - 0.027 13.5 0.0 0.07 12.1 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Abhydrolase_5 PF12695.2 EFE37300.1 - 0.032 14.0 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family AAA_22 PF13401.1 EFE37300.1 - 0.12 12.4 0.0 0.43 10.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain Fructosamin_kin PF03881.9 EFE37301.1 - 3.2e-28 98.5 0.0 4.4e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase CDC45 PF02724.9 EFE37301.1 - 0.0046 15.0 13.7 0.0054 14.8 9.5 1.1 1 0 0 1 1 1 1 CDC45-like protein APH PF01636.18 EFE37301.1 - 0.066 12.9 0.0 0.16 11.6 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family VID27 PF08553.5 EFE37301.1 - 0.1 10.8 17.8 0.14 10.3 12.4 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein RNA_polI_A34 PF08208.6 EFE37301.1 - 2.5 7.7 21.9 3.4 7.2 15.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Nop14 PF04147.7 EFE37301.1 - 8.2 4.2 33.5 10 3.8 23.2 1.1 1 0 0 1 1 1 0 Nop14-like family Aldo_ket_red PF00248.16 EFE37302.1 - 2.9e-26 91.9 0.0 3.7e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.11 EFE37303.1 - 5.7e-11 41.7 26.1 3.4e-08 32.5 7.5 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37303.1 - 7.1e-07 28.1 3.0 7.1e-07 28.1 2.0 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter NADH-u_ox-rdase PF10785.4 EFE37303.1 - 0.1 12.8 0.3 1 9.6 0.2 2.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF92 PF01940.11 EFE37304.1 - 7.1e-62 208.5 5.4 9.3e-62 208.1 3.7 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 TPR_2 PF07719.12 EFE37305.1 - 3.3e-05 23.4 0.0 0.0085 15.9 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 EFE37305.1 - 0.0016 18.0 0.0 0.0096 15.5 0.0 2.3 2 1 0 2 2 2 1 TPR repeat Cohesin_load PF10345.4 EFE37305.1 - 0.026 12.7 0.1 0.86 7.7 0.0 2.0 2 0 0 2 2 2 0 Cohesin loading factor FANCAA PF15146.1 EFE37305.1 - 0.06 12.2 0.4 0.093 11.6 0.3 1.2 1 0 0 1 1 1 0 Fanconi anemia-associated TPR_1 PF00515.23 EFE37305.1 - 0.086 12.4 0.0 3 7.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Cep57_CLD_2 PF14197.1 EFE37305.1 - 0.092 12.6 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 DUF3716 PF12511.3 EFE37306.1 - 2.4e-18 65.4 2.8 3.9e-18 64.8 2.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Replic_Relax PF13814.1 EFE37306.1 - 0.02 14.7 0.8 0.052 13.4 0.2 1.8 2 0 0 2 2 2 0 Replication-relaxation FANCI_S4 PF14678.1 EFE37306.1 - 0.025 13.6 0.1 0.049 12.7 0.0 1.6 2 0 0 2 2 2 0 FANCI solenoid 4 HWE_HK PF07536.9 EFE37306.1 - 0.059 13.8 2.2 0.15 12.5 1.5 1.7 1 0 0 1 1 1 0 HWE histidine kinase TarH PF02203.10 EFE37306.1 - 0.25 11.1 5.0 0.38 10.5 3.5 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue Baculo_PEP_C PF04513.7 EFE37306.1 - 0.83 9.4 5.0 0.26 11.1 0.2 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Methyltransf_33 PF10017.4 EFE37307.1 - 3.4e-28 98.0 0.0 6.3e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent DinB_2 PF12867.2 EFE37307.1 - 2.6e-07 31.0 2.2 7.9e-07 29.4 0.9 2.2 2 0 0 2 2 2 1 DinB superfamily FGE-sulfatase PF03781.11 EFE37307.1 - 9.3e-06 25.1 1.9 0.001 18.5 0.1 2.3 1 1 1 2 2 2 2 Sulfatase-modifying factor enzyme 1 Aldedh PF00171.17 EFE37309.1 - 6.6e-133 443.4 0.0 7.4e-133 443.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EFE37309.1 - 8.4e-07 28.0 0.2 1.2e-05 24.2 0.1 2.1 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Nop25 PF09805.4 EFE37310.1 - 3.5 7.6 10.6 0.39 10.8 3.9 1.9 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Epimerase PF01370.16 EFE37311.1 - 6.8e-07 28.9 0.0 1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Zn_clus PF00172.13 EFE37312.1 - 1.3e-05 24.9 12.1 2.4e-05 24.1 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FYVE PF01363.16 EFE37313.1 - 9e-19 67.1 6.6 9e-19 67.1 4.6 3.2 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.1 EFE37313.1 - 1.1e-08 34.8 4.8 1.1e-08 34.8 3.3 3.4 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.2 EFE37313.1 - 0.00071 19.6 2.4 0.00071 19.6 1.7 3.2 3 0 0 3 3 3 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EFE37313.1 - 0.0034 16.9 3.6 0.0034 16.9 2.5 3.6 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.2 EFE37313.1 - 0.3 11.1 8.5 0.54 10.3 3.4 2.8 2 0 0 2 2 2 0 RING-variant domain FYVE_2 PF02318.11 EFE37313.1 - 0.61 9.9 7.7 0.074 12.9 0.3 2.3 2 0 0 2 2 2 0 FYVE-type zinc finger Elf1 PF05129.8 EFE37313.1 - 6.1 6.6 7.8 1.1 9.0 0.7 2.7 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like DUF678 PF05077.7 EFE37314.1 - 0.26 11.2 2.4 0.35 10.9 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF678) Ras PF00071.17 EFE37315.1 - 3.4e-29 101.3 1.2 1.1e-23 83.3 0.0 3.1 3 0 0 3 3 3 3 Ras family Miro PF08477.8 EFE37315.1 - 7.3e-10 39.3 1.0 9.2e-08 32.5 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein Arf PF00025.16 EFE37315.1 - 0.00082 18.6 0.0 0.013 14.7 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family Carboxyl_trans PF01039.17 EFE37316.1 - 1.8e-144 481.8 0.0 2.3e-144 481.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 EFE37316.1 - 0.026 13.7 0.0 2.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Acyl-CoA_dh_1 PF00441.19 EFE37317.1 - 1.4e-40 138.8 0.6 3.4e-40 137.5 0.4 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EFE37317.1 - 6.2e-35 120.1 0.1 1.5e-34 118.9 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 EFE37317.1 - 3.5e-20 71.2 0.3 1e-19 69.7 0.1 1.9 1 1 1 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFE37317.1 - 1.7e-15 57.4 0.1 3.9e-15 56.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 EFE37317.1 - 0.0013 18.2 0.6 0.0054 16.1 0.5 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal ResB PF05140.9 EFE37318.1 - 0.022 13.3 0.1 0.023 13.2 0.1 1.1 1 0 0 1 1 1 0 ResB-like family CPSase_L_D2 PF02786.12 EFE37319.1 - 1.3e-73 246.7 0.0 1.9e-73 246.2 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 EFE37319.1 - 1.6e-35 121.3 0.0 3.4e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain CPSase_L_chain PF00289.17 EFE37319.1 - 1.1e-33 115.6 0.0 2.9e-33 114.2 0.0 1.8 2 0 0 2 2 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 EFE37319.1 - 2.2e-18 66.6 0.0 7.2e-18 64.9 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl PF00364.17 EFE37319.1 - 1.7e-13 49.9 2.3 4.6e-13 48.5 1.6 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 EFE37319.1 - 2.7e-12 46.0 0.0 4.7e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EFE37319.1 - 1.3e-09 37.7 0.0 3e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 EFE37319.1 - 0.0001 22.1 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 EFE37319.1 - 0.00044 19.8 0.3 0.02 14.5 0.0 2.5 1 1 1 2 2 2 1 Biotin-lipoyl like GARS_A PF01071.14 EFE37319.1 - 0.0046 16.5 0.0 0.0081 15.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.6 EFE37319.1 - 0.0087 15.5 0.0 0.052 13.0 0.0 2.3 3 0 0 3 3 3 1 RimK-like ATP-grasp domain GCV_H PF01597.14 EFE37319.1 - 0.02 14.5 0.4 0.054 13.1 0.3 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein ATPgrasp_ST PF14397.1 EFE37319.1 - 0.098 11.7 0.0 0.24 10.4 0.0 1.6 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp adh_short_C2 PF13561.1 EFE37320.1 - 2.7e-26 92.8 0.0 3.4e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFE37320.1 - 5.7e-20 71.8 0.1 8.5e-20 71.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE37320.1 - 7.6e-11 41.9 0.1 1.4e-10 41.0 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE37320.1 - 0.01 15.2 0.1 0.039 13.3 0.0 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1752 PF08550.5 EFE37321.1 - 5.5e-10 38.6 3.4 1e-09 37.7 2.3 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) MARVEL PF01284.18 EFE37322.1 - 1.6e-10 40.9 3.8 2.5e-10 40.3 2.6 1.3 1 1 0 1 1 1 1 Membrane-associating domain Dispanin PF04505.7 EFE37322.1 - 0.21 11.1 0.1 0.21 11.1 0.1 1.9 2 0 0 2 2 2 0 Interferon-induced transmembrane protein HflK_N PF12221.3 EFE37323.1 - 2 8.2 8.7 4.7 7.0 0.1 3.6 2 1 0 2 2 2 0 Bacterial membrane protein N terminal PHD PF00628.24 EFE37324.1 - 5.8e-10 38.7 2.2 1.4e-09 37.5 1.5 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 EFE37324.1 - 0.0017 17.6 2.6 0.0031 16.7 1.8 1.5 1 0 0 1 1 1 1 PHD-finger PigN PF04987.9 EFE37325.1 - 1.1e-143 479.0 25.6 1.7e-143 478.4 17.8 1.3 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 EFE37325.1 - 1.7e-09 37.5 0.8 4.2e-08 32.9 0.6 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFE37325.1 - 3.3e-09 36.3 0.2 5.3e-09 35.6 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 EFE37325.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily PAD PF03068.10 EFE37325.1 - 0.068 11.5 0.0 0.11 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) DUF4363 PF14276.1 EFE37325.1 - 1.4 8.6 4.6 0.31 10.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) F-box-like_2 PF13013.1 EFE37326.1 - 0.00073 19.2 0.5 0.003 17.2 0.3 1.9 1 1 0 1 1 1 1 F-box-like domain eIF-5a PF01287.15 EFE37327.1 - 0.0015 18.4 0.0 0.0033 17.3 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold MFS_1 PF07690.11 EFE37328.1 - 1.2e-42 145.8 19.2 1.2e-42 145.8 13.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37328.1 - 3.4e-11 42.3 3.7 5.5e-11 41.7 2.5 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.2 EFE37328.1 - 0.0013 18.5 0.5 1.4 8.7 0.1 3.1 2 1 1 3 3 3 2 MFS_1 like family OATP PF03137.15 EFE37328.1 - 0.0068 14.5 0.6 0.012 13.7 0.4 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF3353 PF11833.3 EFE37328.1 - 0.011 15.1 2.3 0.027 13.9 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3353) Chloroplast_duf PF14476.1 EFE37328.1 - 0.58 8.9 3.2 3.5 6.3 0.2 2.3 2 0 0 2 2 2 0 Petal formation-expressed YhhN PF07947.9 EFE37329.1 - 1.2e-39 135.6 4.3 1.7e-39 135.0 3.0 1.2 1 0 0 1 1 1 1 YhhN-like protein Abhydrolase_6 PF12697.2 EFE37333.1 - 2.6e-30 106.0 2.9 6.2e-30 104.7 2.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE37333.1 - 4.1e-13 49.4 0.3 2.1e-12 47.1 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE37333.1 - 2.9e-11 43.3 0.0 7.6e-10 38.7 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EFE37333.1 - 4.2e-07 29.7 0.0 1.4e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 Putative lysophospholipase Chlorophyllase PF07224.6 EFE37333.1 - 0.015 14.1 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Peptidase_S9 PF00326.16 EFE37333.1 - 0.015 14.5 0.1 0.083 12.0 0.2 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 EFE37333.1 - 0.035 12.9 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Esterase PF00756.15 EFE37333.1 - 0.062 12.7 0.1 0.16 11.3 0.1 1.7 1 1 0 1 1 1 0 Putative esterase SRR1 PF07985.7 EFE37336.1 - 3.7e-05 23.5 0.1 7.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 SRR1 RRP7 PF12923.2 EFE37336.1 - 0.0028 17.6 1.2 0.0035 17.3 0.2 1.6 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) PsaL PF02605.10 EFE37336.1 - 0.07 12.6 0.2 0.25 10.8 0.0 2.0 1 1 1 2 2 2 0 Photosystem I reaction centre subunit XI bZIP_1 PF00170.16 EFE37337.1 - 0.0088 15.9 4.3 0.016 15.1 3.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.10 EFE37337.1 - 0.023 14.1 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 Septum formation initiator ABM PF03992.11 EFE37338.1 - 0.0027 17.6 0.1 0.57 10.2 0.0 2.9 3 0 0 3 3 3 2 Antibiotic biosynthesis monooxygenase MFS_1 PF07690.11 EFE37339.1 - 4.8e-40 137.3 52.4 4.8e-40 137.3 36.3 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE37339.1 - 9.8e-18 63.6 25.0 1.2e-17 63.3 17.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.13 EFE37340.1 - 6.8e-06 25.1 0.4 4.9e-05 22.3 0.0 2.6 2 1 0 2 2 2 1 Fungal specific transcription factor domain PAT1 PF09770.4 EFE37340.1 - 3.3 5.8 22.5 4.4 5.4 15.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BAF1_ABF1 PF04684.8 EFE37340.1 - 5.8 5.6 15.7 8.6 5.0 10.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MFS_1 PF07690.11 EFE37342.1 - 6.3e-15 54.7 48.5 6.6e-12 44.8 20.0 3.3 2 1 0 2 2 2 2 Major Facilitator Superfamily Phage_hub_GP28 PF11110.3 EFE37342.1 - 0.17 11.5 0.7 0.29 10.8 0.5 1.3 1 0 0 1 1 1 0 Baseplate hub distal subunit RHD3 PF05879.7 EFE37343.1 - 6.9e-290 963.2 0.0 1.7e-217 723.9 0.0 2.0 1 1 1 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 EFE37343.1 - 9.6e-08 31.3 0.1 1.8e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 EFE37343.1 - 2.7e-06 27.2 0.1 5.4e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 EFE37343.1 - 7.3e-05 22.7 0.0 0.00015 21.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.1 EFE37343.1 - 0.00012 22.1 0.2 0.00061 19.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain Septin PF00735.13 EFE37343.1 - 0.00051 19.1 0.1 0.0012 17.8 0.1 1.6 1 0 0 1 1 1 1 Septin Miro PF08477.8 EFE37343.1 - 0.00077 19.9 0.1 0.0017 18.8 0.1 1.6 1 0 0 1 1 1 1 Miro-like protein AAA_26 PF13500.1 EFE37343.1 - 0.16 11.5 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain DIM1 PF02966.11 EFE37344.1 - 2.3e-69 231.0 0.1 2.5e-69 230.9 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_8 PF13905.1 EFE37344.1 - 0.012 15.7 0.4 0.023 14.8 0.3 1.5 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin PF00085.15 EFE37344.1 - 0.014 15.0 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin 4HBT_2 PF13279.1 EFE37345.1 - 2.4e-06 28.0 0.0 3.2e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily HIG_1_N PF04588.8 EFE37346.1 - 1.1e-06 28.2 0.3 1.1e-06 28.2 0.2 2.0 2 0 0 2 2 2 1 Hypoxia induced protein conserved region Med26 PF08711.6 EFE37347.1 - 2.7e-11 42.7 0.1 5.1e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Nup54 PF13874.1 EFE37348.1 - 7e-46 155.3 0.6 7e-46 155.3 0.4 2.4 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.1 EFE37348.1 - 4.4e-08 33.3 39.7 4.4e-08 33.3 27.5 2.5 1 1 1 2 2 2 1 Nucleoporin FG repeat region Fib_alpha PF08702.5 EFE37348.1 - 0.034 14.2 0.7 0.034 14.2 0.5 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Uds1 PF15456.1 EFE37348.1 - 10 6.1 11.8 33 4.4 1.8 3.0 1 1 1 2 2 2 0 Up-regulated During Septation AAA PF00004.24 EFE37349.1 - 9.4e-15 54.9 0.0 2.3e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFE37349.1 - 4.8e-11 42.9 0.2 5.9e-10 39.4 0.0 2.7 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 EFE37349.1 - 3.6e-09 36.8 0.0 1.5e-07 31.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE37349.1 - 8.1e-06 25.5 0.1 3.7e-05 23.3 0.1 2.2 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 EFE37349.1 - 0.0006 20.6 0.0 0.0059 17.4 0.0 2.5 3 0 0 3 3 2 1 AAA domain AAA_11 PF13086.1 EFE37349.1 - 0.00068 19.2 0.0 0.0014 18.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EFE37349.1 - 0.00093 19.1 0.0 0.0024 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 EFE37349.1 - 0.0029 17.2 0.0 0.0088 15.7 0.0 1.8 1 1 0 1 1 1 1 NACHT domain DUF2075 PF09848.4 EFE37349.1 - 0.0053 15.7 0.0 0.11 11.5 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.9 EFE37349.1 - 0.0068 15.4 0.0 0.037 13.0 0.0 2.0 2 0 0 2 2 2 1 KAP family P-loop domain Arch_ATPase PF01637.13 EFE37349.1 - 0.01 15.5 0.0 0.078 12.6 0.0 2.2 1 1 0 1 1 1 0 Archaeal ATPase RNA_helicase PF00910.17 EFE37349.1 - 0.014 15.5 0.0 0.076 13.1 0.0 2.3 3 0 0 3 3 2 0 RNA helicase AAA_33 PF13671.1 EFE37349.1 - 0.019 14.8 0.0 0.23 11.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain BAH PF01426.13 EFE37349.1 - 0.033 13.9 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 BAH domain PIF1 PF05970.9 EFE37349.1 - 0.058 12.3 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase Zot PF05707.7 EFE37349.1 - 0.075 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_32 PF13654.1 EFE37349.1 - 0.076 11.6 0.0 0.17 10.5 0.0 1.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 EFE37349.1 - 0.15 11.7 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 NTPase WD40 PF00400.27 EFE37350.1 - 1.5e-52 173.6 12.6 2.8e-10 39.6 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 EFE37350.1 - 0.0014 16.9 3.9 5.6 4.9 0.0 4.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Ank_2 PF12796.2 EFE37351.1 - 7.3e-50 167.2 1.0 5e-19 68.4 0.2 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE37351.1 - 1e-35 121.4 4.7 8.6e-09 35.6 0.0 4.9 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.25 EFE37351.1 - 9.4e-32 107.2 0.3 8.6e-05 22.1 0.0 6.1 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.1 EFE37351.1 - 5.3e-31 105.9 0.9 2.5e-08 33.9 0.1 4.9 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE37351.1 - 1.5e-27 92.8 0.5 0.0024 17.9 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Shal-type PF11601.3 EFE37351.1 - 0.02 14.4 0.2 0.12 11.8 0.0 2.1 2 0 0 2 2 2 0 Shal-type voltage-gated potassium channels TMF_TATA_bd PF12325.3 EFE37352.1 - 5.1e-42 142.4 13.2 5.1e-42 142.4 9.1 6.5 3 2 2 6 6 6 2 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 EFE37352.1 - 2.4e-22 78.4 19.1 2.4e-22 78.4 13.2 8.7 5 3 2 7 7 7 1 TATA element modulatory factor 1 DNA binding Pkinase PF00069.20 EFE37353.1 - 3e-12 46.2 0.0 4.4e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37353.1 - 3.1e-12 46.1 0.0 9.9e-12 44.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Crystall_2 PF09076.5 EFE37353.1 - 0.04 13.6 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 Beta/Gamma crystallin V-ATPase_H_N PF03224.9 EFE37354.1 - 1.3e-79 267.5 0.0 1.9e-79 267.0 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 EFE37354.1 - 3.8e-38 130.0 0.0 1.1e-37 128.5 0.0 1.8 2 0 0 2 2 2 1 V-ATPase subunit H ATP_bind_1 PF03029.12 EFE37357.1 - 2.8e-75 252.9 0.0 3.3e-75 252.7 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 EFE37357.1 - 1.2e-05 26.1 0.0 4.1e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFE37357.1 - 0.00012 21.9 0.0 0.00038 20.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EFE37357.1 - 0.00042 20.0 0.0 0.00082 19.0 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 EFE37357.1 - 0.00098 19.2 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.1 EFE37357.1 - 0.0011 18.8 0.2 0.017 15.0 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE37357.1 - 0.002 18.0 0.0 0.0031 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE37357.1 - 0.002 18.1 0.0 0.0069 16.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 EFE37357.1 - 0.0022 17.6 0.0 0.0043 16.7 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain GTP_EFTU PF00009.22 EFE37357.1 - 0.0029 17.0 0.1 1.5 8.2 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RNA_helicase PF00910.17 EFE37357.1 - 0.0034 17.5 0.0 0.0082 16.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA PF00004.24 EFE37357.1 - 0.0038 17.4 0.0 0.0079 16.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.17 EFE37357.1 - 0.0039 16.6 0.0 0.007 15.8 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_24 PF13479.1 EFE37357.1 - 0.0051 16.4 0.0 0.0085 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 EFE37357.1 - 0.012 15.2 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 EFE37357.1 - 0.012 15.2 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain T2SE PF00437.15 EFE37357.1 - 0.013 14.4 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.12 EFE37357.1 - 0.034 13.5 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein KaiC PF06745.8 EFE37357.1 - 0.035 13.2 0.0 0.071 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_10 PF12846.2 EFE37357.1 - 0.035 13.5 0.0 0.14 11.5 0.0 1.8 2 1 0 2 2 2 0 AAA-like domain CbiA PF01656.18 EFE37357.1 - 0.037 13.4 0.0 0.052 12.9 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Arch_ATPase PF01637.13 EFE37357.1 - 0.041 13.5 0.0 0.6 9.7 0.0 2.1 2 0 0 2 2 2 0 Archaeal ATPase cobW PF02492.14 EFE37357.1 - 0.041 13.3 0.1 0.23 10.9 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.13 EFE37357.1 - 0.042 12.8 0.0 0.075 12.0 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_25 PF13481.1 EFE37357.1 - 0.047 13.0 0.0 0.14 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain PPV_E1_C PF00519.12 EFE37357.1 - 0.06 11.9 0.0 0.094 11.3 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_18 PF13238.1 EFE37357.1 - 0.061 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.9 EFE37357.1 - 0.062 12.2 0.0 0.062 12.2 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain AAA_5 PF07728.9 EFE37357.1 - 0.066 12.9 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 EFE37357.1 - 0.074 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter KTI12 PF08433.5 EFE37357.1 - 0.1 11.8 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF463 PF04317.7 EFE37357.1 - 0.11 11.0 0.0 0.18 10.3 0.0 1.3 1 0 0 1 1 1 0 YcjX-like family, DUF463 AAA_30 PF13604.1 EFE37357.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EFE37357.1 - 0.13 11.7 0.0 0.38 10.2 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.13 EFE37357.1 - 0.14 11.5 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family NTPase_1 PF03266.10 EFE37357.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 NTPase S-AdoMet_synt_C PF02773.11 EFE37358.1 - 1.2e-76 255.0 1.9 1.6e-76 254.6 0.2 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 EFE37358.1 - 1.4e-48 163.8 0.0 2.2e-48 163.1 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 EFE37358.1 - 3.2e-13 49.7 0.4 1.3e-12 47.8 0.0 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain SLD3 PF08639.5 EFE37359.1 - 9.4e-118 393.9 13.7 3.9e-117 391.9 9.5 1.8 1 1 0 1 1 1 1 DNA replication regulator SLD3 Pro-MCH PF05824.7 EFE37361.1 - 0.43 10.0 0.0 0.43 10.0 0.0 2.2 2 0 0 2 2 2 0 Pro-melanin-concentrating hormone (Pro-MCH) E1-E2_ATPase PF00122.15 EFE37362.1 - 1.8e-20 72.9 0.1 1.2e-19 70.2 0.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 EFE37362.1 - 2e-14 54.5 0.5 7.1e-13 49.4 0.4 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE37362.1 - 1.1e-12 47.7 0.0 3.6e-12 46.0 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE37362.1 - 1e-10 42.1 0.1 2.1e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE37362.1 - 0.0019 17.8 0.2 0.0065 16.0 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase G_glu_transpept PF01019.16 EFE37363.1 - 7.6e-126 420.5 0.0 8.5e-126 420.4 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase p450 PF00067.17 EFE37364.1 - 3.6e-27 95.0 0.0 6e-27 94.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 NADHdeh_related PF10125.4 EFE37365.1 - 0.089 11.9 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 NADH dehydrogenase I, subunit N related protein Sugar_tr PF00083.19 EFE37367.1 - 2.3e-82 276.9 22.2 2.6e-82 276.7 15.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE37367.1 - 1.5e-14 53.4 33.3 5.3e-14 51.6 17.1 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF3278 PF11683.3 EFE37367.1 - 0.37 10.7 4.9 6.3 6.8 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) Peptidase_S8 PF00082.17 EFE37368.1 - 2.3e-44 151.6 13.9 3.7e-44 150.9 9.6 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE37368.1 - 4.5e-14 52.7 0.4 7.5e-14 52.0 0.3 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Nramp PF01566.13 EFE37369.1 - 5.2e-76 255.7 24.3 3.4e-45 154.3 1.3 2.9 2 1 1 3 3 3 2 Natural resistance-associated macrophage protein CAML PF14963.1 EFE37369.1 - 8.9 5.5 7.7 0.24 10.7 0.1 2.1 3 0 0 3 3 3 0 Calcium signal-modulating cyclophilin ligand Aminotran_4 PF01063.14 EFE37370.1 - 1.8e-24 86.5 0.0 2.3e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV TPR_11 PF13414.1 EFE37371.1 - 1.4e-51 172.0 29.9 7.2e-14 51.1 0.6 7.6 3 2 5 9 9 9 9 TPR repeat TPR_1 PF00515.23 EFE37371.1 - 1.1e-40 135.6 34.2 4.5e-06 26.0 0.1 11.4 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.12 EFE37371.1 - 1.6e-39 130.6 33.4 5.5e-05 22.7 0.1 11.6 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_16 PF13432.1 EFE37371.1 - 5.7e-27 93.7 26.4 4e-07 30.5 0.1 6.8 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.1 EFE37371.1 - 8.7e-26 89.6 32.9 2.2e-07 30.6 0.9 7.4 2 2 5 7 7 7 7 Tetratricopeptide repeat TPR_17 PF13431.1 EFE37371.1 - 5.6e-19 66.6 17.7 0.026 14.7 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.1 EFE37371.1 - 7.1e-16 56.6 19.8 0.0099 15.6 0.5 10.0 9 1 1 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.1 EFE37371.1 - 7.8e-15 53.4 32.4 0.012 15.3 0.1 10.9 9 2 2 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.1 EFE37371.1 - 1e-13 51.4 26.0 2.7e-06 27.6 1.5 7.5 3 2 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFE37371.1 - 1.1e-13 50.4 24.5 0.019 15.5 0.8 10.6 3 3 8 11 11 11 4 Tetratricopeptide repeat TPR_9 PF13371.1 EFE37371.1 - 2.6e-13 49.6 16.8 5.8e-05 22.8 0.1 6.6 4 2 4 8 8 7 4 Tetratricopeptide repeat Apc3 PF12895.2 EFE37371.1 - 1.4e-10 41.1 22.3 0.0046 17.0 0.8 5.4 3 1 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.4 EFE37371.1 - 0.0018 17.5 15.2 0.91 8.8 0.0 7.6 8 0 0 8 8 8 1 SHNi-TPR TPR_10 PF13374.1 EFE37371.1 - 0.0033 17.3 20.1 0.18 11.8 0.5 7.5 8 0 0 8 8 8 1 Tetratricopeptide repeat DUF1510 PF07423.6 EFE37371.1 - 0.0065 15.8 1.8 0.012 15.0 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) DUF3856 PF12968.2 EFE37371.1 - 0.0075 16.0 6.0 3.7 7.3 0.0 5.0 4 2 1 5 5 5 1 Domain of Unknown Function (DUF3856) TPR_6 PF13174.1 EFE37371.1 - 0.013 15.8 29.0 4 8.1 0.6 9.5 11 0 0 11 11 9 0 Tetratricopeptide repeat RPN7 PF10602.4 EFE37371.1 - 0.026 13.9 6.2 5.8 6.2 0.0 4.3 3 1 0 3 3 3 0 26S proteasome subunit RPN7 Sel1 PF08238.7 EFE37371.1 - 0.21 12.2 11.8 0.76 10.4 0.2 4.7 4 0 0 4 4 3 0 Sel1 repeat TPR_3 PF07720.7 EFE37371.1 - 4.1 7.3 14.9 8.4 6.3 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TGT PF01702.13 EFE37372.1 - 0.49 9.6 2.2 1.9 7.6 1.0 2.0 1 1 1 2 2 2 0 Queuine tRNA-ribosyltransferase DUF4551 PF15087.1 EFE37372.1 - 6.2 5.0 18.8 8.5 4.6 13.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Amidohydro_1 PF01979.15 EFE37373.1 - 9.3e-64 216.1 0.4 4e-63 214.0 0.3 1.9 2 0 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.15 EFE37373.1 - 3.6e-53 178.8 1.5 7.1e-53 177.8 1.0 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.15 EFE37373.1 - 3.1e-40 136.0 0.2 3.9e-39 132.5 0.0 2.2 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.13 EFE37373.1 - 1.7e-36 124.1 0.0 3.5e-36 123.1 0.0 1.5 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_5 PF13594.1 EFE37373.1 - 1.6e-06 27.7 4.3 5.2e-06 26.1 3.0 1.9 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EFE37373.1 - 0.00011 21.6 0.2 0.0022 17.2 0.0 2.3 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_4 PF13147.1 EFE37373.1 - 0.025 14.6 0.0 6.8 6.6 0.0 2.5 2 0 0 2 2 2 0 Amidohydrolase DRMBL PF07522.9 EFE37374.1 - 2.5e-06 27.5 0.3 1.1e-05 25.3 0.0 2.2 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 EFE37375.1 - 1.5e-05 24.6 0.0 2e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EFE37375.1 - 0.004 16.8 0.0 0.0066 16.1 0.0 1.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF3925 PF13063.1 EFE37376.1 - 0.04 13.9 0.6 0.083 12.9 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3925) Cut8_N PF14482.1 EFE37377.1 - 0.25 11.3 0.1 0.25 11.3 0.1 2.7 2 1 1 3 3 3 0 Cut8 proteasome-binding domain N6_N4_Mtase PF01555.13 EFE37377.1 - 6 6.2 6.3 6.6 6.1 4.4 1.0 1 0 0 1 1 1 0 DNA methylase VHS PF00790.14 EFE37379.1 - 9.9e-30 103.0 0.1 6e-29 100.4 0.0 2.2 2 0 0 2 2 2 1 VHS domain GAT PF03127.9 EFE37379.1 - 1.9e-25 88.7 1.3 6.2e-25 87.0 0.9 1.9 1 0 0 1 1 1 1 GAT domain Alpha_adaptinC2 PF02883.15 EFE37379.1 - 0.0019 18.4 0.2 0.0019 18.4 0.1 2.2 2 0 0 2 2 2 1 Adaptin C-terminal domain DUF605 PF04652.11 EFE37379.1 - 2 7.7 12.0 3 7.1 8.3 1.3 1 0 0 1 1 1 0 Vta1 like DUF367 PF04034.8 EFE37380.1 - 8.6e-29 99.7 0.2 1.4e-28 99.0 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF367) Peptidase_C37 PF05416.7 EFE37380.1 - 0.0034 15.7 4.6 0.0045 15.3 3.2 1.1 1 0 0 1 1 1 1 Southampton virus-type processing peptidase SGT1 PF07093.6 EFE37380.1 - 0.13 10.6 10.7 0.15 10.3 7.4 1.1 1 0 0 1 1 1 0 SGT1 protein BUD22 PF09073.5 EFE37380.1 - 0.6 9.1 15.2 0.74 8.8 10.5 1.1 1 0 0 1 1 1 0 BUD22 Treacle PF03546.9 EFE37380.1 - 1.9 7.1 13.2 0.019 13.7 3.5 1.7 1 1 0 1 1 1 0 Treacher Collins syndrome protein Treacle zf-H2C2 PF09337.5 EFE37381.1 - 2.6e-21 74.7 4.1 2.6e-21 74.7 2.8 1.9 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger Acetyltransf_4 PF13420.1 EFE37381.1 - 0.0012 18.7 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE37381.1 - 0.0022 17.9 0.0 0.0049 16.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 EFE37381.1 - 0.071 13.2 0.0 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Cpn60_TCP1 PF00118.19 EFE37382.1 - 1.7e-62 211.6 2.7 2e-62 211.4 1.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MCP_N PF05581.7 EFE37382.1 - 0.13 12.4 1.6 6.6 6.9 0.2 2.4 1 1 1 2 2 2 0 Vibrio chemotaxis protein N terminus BCS1_N PF08740.6 EFE37384.1 - 5.3e-48 163.1 0.4 7.9e-48 162.5 0.3 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 EFE37384.1 - 1.7e-16 60.5 0.0 3e-08 33.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE37384.1 - 0.00092 20.0 1.2 0.0027 18.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 EFE37384.1 - 0.0015 17.6 0.0 0.0025 16.8 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EFE37384.1 - 0.0047 16.9 0.0 0.047 13.6 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 EFE37384.1 - 0.047 13.0 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFE37384.1 - 0.053 13.8 0.6 0.23 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 EFE37384.1 - 0.07 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 KaiC Polyoma_lg_T_C PF06431.6 EFE37384.1 - 0.088 11.4 0.0 0.088 11.4 0.0 1.5 2 0 0 2 2 2 0 Polyomavirus large T antigen C-terminus HNH_2 PF13391.1 EFE37385.1 - 9.4e-09 34.9 0.2 3.6e-08 33.0 0.1 2.0 2 0 0 2 2 2 1 HNH endonuclease SRP19 PF01922.12 EFE37388.1 - 3.4e-29 101.2 0.0 7.3e-29 100.2 0.0 1.5 2 0 0 2 2 2 1 SRP19 protein PG_binding_1 PF01471.13 EFE37388.1 - 0.092 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative peptidoglycan binding domain TCTP PF00838.12 EFE37389.1 - 7e-25 87.9 0.1 7.8e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF2717 PF10911.3 EFE37389.1 - 0.074 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2717) TCTP PF00838.12 EFE37390.1 - 3e-27 95.6 1.0 3.9e-27 95.2 0.7 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF4131 PF13567.1 EFE37390.1 - 0.059 12.7 0.7 0.085 12.2 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) GMC_oxred_N PF00732.14 EFE37391.1 - 1.1e-46 159.3 0.5 1.5e-46 158.8 0.4 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFE37391.1 - 1.7e-28 99.6 0.4 1.3e-27 96.9 0.0 2.3 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EFE37391.1 - 1.9e-07 30.2 0.1 2.6e-05 23.2 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.9 EFE37391.1 - 0.00033 20.5 0.3 0.001 18.9 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFE37391.1 - 0.00058 19.0 0.4 0.0018 17.4 0.1 1.8 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 EFE37391.1 - 0.00083 18.3 9.2 0.013 14.3 6.3 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE37391.1 - 0.004 17.1 1.5 0.012 15.6 0.4 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 EFE37391.1 - 0.0051 15.9 0.1 0.0085 15.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 EFE37391.1 - 0.064 12.3 0.5 0.1 11.6 0.4 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase JSRP PF15312.1 EFE37393.1 - 3.1 7.8 5.3 0.84 9.6 1.1 1.9 2 0 0 2 2 2 0 Junctional sarcoplasmic reticulum protein Bul1_N PF04425.7 EFE37395.1 - 1.2e-07 30.6 1.5 1.7e-06 26.8 1.0 2.1 1 1 0 1 1 1 1 Bul1 N terminus Arrestin_N PF00339.24 EFE37395.1 - 0.00045 20.0 0.0 0.0017 18.1 0.0 2.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.7 EFE37395.1 - 0.0024 17.0 0.0 0.0087 15.2 0.0 1.7 2 0 0 2 2 2 1 Bul1 C terminus SMI1_KNR4 PF09346.5 EFE37396.1 - 2e-35 121.6 0.0 3.1e-35 121.0 0.0 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) DUF4160 PF13711.1 EFE37396.1 - 0.11 12.3 0.5 19 5.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) Thioredoxin PF00085.15 EFE37397.1 - 0.00051 19.6 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin HlyD_2 PF12700.2 EFE37397.1 - 0.0035 16.5 0.2 0.0047 16.1 0.1 1.2 1 0 0 1 1 1 1 HlyD family secretion protein Herpes_UL36 PF03586.8 EFE37397.1 - 0.039 13.0 0.3 0.06 12.4 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein DUF1635 PF07795.6 EFE37397.1 - 0.92 8.8 5.8 1.3 8.3 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Peptidase_M14 PF00246.19 EFE37398.1 - 2.4e-72 243.8 0.0 4.8e-72 242.8 0.0 1.5 2 0 0 2 2 2 1 Zinc carboxypeptidase Propep_M14 PF02244.11 EFE37398.1 - 3.4e-09 36.2 0.1 1.2e-08 34.5 0.1 2.0 2 0 0 2 2 2 1 Carboxypeptidase activation peptide AstE_AspA PF04952.9 EFE37398.1 - 0.083 11.7 0.2 0.14 11.0 0.1 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Methyltransf_25 PF13649.1 EFE37399.1 - 1.4e-13 51.0 0.0 3e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE37399.1 - 1.9e-11 44.4 0.0 3.4e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE37399.1 - 1.1e-08 34.9 0.0 1.6e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE37399.1 - 3.8e-08 33.0 0.0 5e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE37399.1 - 1.1e-07 32.2 0.0 1.8e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE37399.1 - 1.1e-07 32.2 0.1 3e-07 30.8 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE37399.1 - 9.4e-06 25.6 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE37399.1 - 0.0067 15.5 0.0 0.009 15.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 EFE37399.1 - 0.0084 15.4 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_20 PF12147.3 EFE37399.1 - 0.019 13.8 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_16 PF10294.4 EFE37399.1 - 0.02 14.3 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase TehB PF03848.9 EFE37399.1 - 0.035 13.2 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB FSH1 PF03959.8 EFE37400.1 - 2e-29 102.6 0.0 2.5e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 EFE37400.1 - 0.0021 17.7 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE37400.1 - 0.0026 17.6 0.0 0.1 12.4 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFE37400.1 - 0.0085 15.5 0.4 1.5 8.2 0.2 2.7 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase DRY_EERY PF09750.4 EFE37400.1 - 0.067 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Alternative splicing regulator HSBP1 PF06825.7 EFE37401.1 - 4.5e-06 26.1 2.2 0.11 12.1 0.0 4.9 4 1 0 4 4 4 2 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.7 EFE37401.1 - 0.00017 21.4 32.5 0.028 14.2 0.7 5.6 3 2 2 6 6 6 4 Baculovirus polyhedron envelope protein, PEP, C terminus HrpB7 PF09486.5 EFE37401.1 - 0.0094 15.8 1.6 0.0094 15.8 1.1 3.9 3 1 0 3 3 3 1 Bacterial type III secretion protein (HrpB7) FlaC_arch PF05377.6 EFE37401.1 - 0.0095 15.8 21.0 0.26 11.2 1.3 6.6 6 2 2 8 8 8 2 Flagella accessory protein C (FlaC) GAS PF13851.1 EFE37401.1 - 0.012 14.8 0.3 0.012 14.8 0.2 4.8 2 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding Cortex-I_coil PF09304.5 EFE37401.1 - 0.023 14.7 0.9 0.023 14.7 0.6 6.7 3 2 3 7 7 7 0 Cortexillin I, coiled coil Reo_sigmaC PF04582.7 EFE37401.1 - 0.024 13.8 27.0 0.1 11.7 7.1 4.0 3 2 1 4 4 4 0 Reovirus sigma C capsid protein DUF2968 PF11180.3 EFE37401.1 - 0.033 13.5 0.3 0.033 13.5 0.2 4.0 4 1 1 5 5 5 0 Protein of unknown function (DUF2968) DUF1043 PF06295.7 EFE37401.1 - 0.4 10.3 10.2 0.046 13.3 1.6 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF1043) COG2 PF06148.6 EFE37401.1 - 0.47 10.3 19.2 0.51 10.2 0.7 4.8 4 2 1 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Snapin_Pallidin PF14712.1 EFE37401.1 - 2.7 8.3 27.0 0.64 10.3 2.7 5.6 3 2 1 6 6 6 0 Snapin/Pallidin Matrilin_ccoil PF10393.4 EFE37401.1 - 6.1 6.2 8.3 4.4 6.7 0.0 4.5 4 2 1 5 5 5 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF3584 PF12128.3 EFE37401.1 - 6.6 3.9 40.0 0.62 7.3 10.2 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF3584) TIP49 PF06068.8 EFE37402.1 - 3.2e-173 576.0 2.2 3.7e-173 575.8 1.5 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 EFE37402.1 - 4.4e-08 33.3 0.1 5.3e-05 23.4 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFE37402.1 - 8.6e-07 28.2 1.5 0.00027 20.0 0.0 2.6 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus DnaB_C PF03796.10 EFE37402.1 - 6.8e-05 21.8 0.2 0.00011 21.1 0.2 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.1 EFE37402.1 - 0.00021 21.3 0.0 0.0015 18.5 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFE37402.1 - 0.00028 21.0 0.0 0.26 11.4 0.0 2.5 1 1 1 2 2 2 2 AAA domain Mg_chelatase PF01078.16 EFE37402.1 - 0.0017 17.5 0.8 0.022 13.8 0.2 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFE37402.1 - 0.0072 16.0 0.1 0.48 10.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 EFE37402.1 - 0.0076 16.1 0.0 3.9 7.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EFE37402.1 - 0.023 14.4 0.1 0.056 13.1 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain Sigma54_activat PF00158.21 EFE37402.1 - 0.028 13.8 0.0 8.2 5.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.1 EFE37402.1 - 0.036 13.4 0.1 0.068 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 EFE37402.1 - 0.073 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_33 PF13671.1 EFE37402.1 - 0.1 12.4 0.0 0.62 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain GYF PF02213.11 EFE37403.1 - 1.7e-08 33.9 1.0 3.5e-08 32.9 0.7 1.5 1 0 0 1 1 1 1 GYF domain UFD1 PF03152.9 EFE37404.1 - 7.3e-65 217.3 0.0 2.8e-63 212.2 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.12 EFE37404.1 - 0.054 13.1 0.0 0.15 11.6 0.0 1.7 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), domain 2 DUF1299 PF06975.6 EFE37405.1 - 0.03 14.1 2.6 0.069 13.0 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1299) MAP65_ASE1 PF03999.7 EFE37405.1 - 0.12 10.9 2.2 0.14 10.7 1.5 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ORC6 PF05460.8 EFE37405.1 - 1.8 7.6 7.6 4.1 6.3 5.7 1.3 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Period_C PF12114.3 EFE37407.1 - 6.7 6.2 11.8 9.1 5.8 8.2 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF3827 PF12877.2 EFE37407.1 - 9.2 4.2 7.5 12 3.8 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Ribosomal_60s PF00428.14 EFE37409.1 - 0.00074 19.8 3.1 0.00074 19.8 2.1 2.0 1 1 1 2 2 2 1 60s Acidic ribosomal protein DUF3537 PF12056.3 EFE37409.1 - 0.018 13.7 2.4 0.021 13.5 1.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) TMEM171 PF15471.1 EFE37410.1 - 2.3 6.9 9.0 3.3 6.3 6.2 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 ORC6 PF05460.8 EFE37413.1 - 0.001 18.2 5.4 0.0013 17.9 3.8 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Abp2 PF09441.5 EFE37414.1 - 3.2e-82 274.6 0.1 5.5e-82 273.9 0.0 1.3 1 0 0 1 1 1 1 ARS binding protein 2 WW PF00397.21 EFE37417.1 - 3.7e-07 29.8 2.7 7.9e-07 28.8 1.9 1.6 1 0 0 1 1 1 1 WW domain DS PF01916.12 EFE37418.1 - 5e-143 475.6 0.0 5.8e-143 475.4 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase CmcH_NodU PF02543.10 EFE37418.1 - 0.11 11.6 0.1 0.2 10.7 0.1 1.4 1 0 0 1 1 1 0 Carbamoyltransferase UCH PF00443.24 EFE37419.1 - 2e-11 43.5 0.0 3.3e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_3 PF13920.1 EFE37419.1 - 1.2e-10 40.8 11.4 2.2e-10 40.0 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MORN PF02493.15 EFE37419.1 - 3.4e-06 26.4 23.6 0.023 14.4 3.3 4.6 4 0 0 4 4 4 3 MORN repeat zf-C3HC4_2 PF13923.1 EFE37419.1 - 0.00087 19.2 11.5 0.00098 19.1 6.5 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE37419.1 - 0.2 11.3 12.2 0.41 10.4 8.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DUF4356 PF14266.1 EFE37419.1 - 0.32 9.3 0.0 0.5 8.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4356) Pkinase PF00069.20 EFE37420.1 - 3.9e-26 91.7 0.0 1.8e-25 89.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37420.1 - 1.4e-14 53.7 0.0 3e-13 49.4 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.17 EFE37420.1 - 0.075 12.3 0.0 0.2 10.9 0.0 1.6 1 1 0 1 1 1 0 RIO1 family Abhydrolase_6 PF12697.2 EFE37422.1 - 2.9e-15 56.7 0.6 3.9e-15 56.3 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE37422.1 - 2.5e-06 27.2 0.0 4.9e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE37422.1 - 1e-05 25.2 0.1 6.1e-05 22.6 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold EHN PF06441.7 EFE37422.1 - 0.066 13.1 0.1 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Epoxide hydrolase N terminus HsbA PF12296.3 EFE37423.1 - 1.2e-32 112.4 4.8 1.2e-32 112.4 3.3 2.2 2 1 0 2 2 2 1 Hydrophobic surface binding protein A Talin_middle PF09141.5 EFE37423.1 - 0.0032 17.1 3.6 0.0062 16.2 2.5 1.4 1 1 0 1 1 1 1 Talin, middle domain DUF4179 PF13786.1 EFE37423.1 - 0.014 15.6 1.9 0.031 14.4 1.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) DUF3216 PF11505.3 EFE37423.1 - 0.1 12.3 0.2 0.71 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3216) Bundlin PF05307.6 EFE37423.1 - 0.18 11.6 2.2 0.19 11.6 0.3 1.9 2 0 0 2 2 2 0 Bundlin PIG-P PF08510.7 EFE37424.1 - 6.7e-44 148.5 0.2 6.7e-44 148.5 0.1 2.2 3 0 0 3 3 3 1 PIG-P Lin-8 PF03353.10 EFE37424.1 - 0.66 9.1 3.7 0.2 10.8 0.7 1.5 1 1 1 2 2 2 0 Ras-mediated vulval-induction antagonist DPM2 PF07297.7 EFE37424.1 - 2.6 8.3 8.9 4.7 7.5 6.2 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) XPA_C PF05181.7 EFE37425.1 - 1.3e-29 101.5 2.5 3.5e-29 100.1 1.7 1.8 1 0 0 1 1 1 1 XPA protein C-terminus YhfH PF14149.1 EFE37425.1 - 0.0026 17.5 3.7 0.25 11.1 0.1 2.6 2 0 0 2 2 2 2 YhfH-like protein DUF2406 PF10295.4 EFE37425.1 - 0.044 14.3 0.1 0.13 12.8 0.1 1.9 1 0 0 1 1 1 0 Uncharacterised protein (DUF2406) OrfB_Zn_ribbon PF07282.6 EFE37425.1 - 1.2 8.8 5.6 24 4.6 0.0 2.7 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Striatin PF08232.7 EFE37426.1 - 8.9e-45 152.3 3.7 8.9e-45 152.3 2.6 2.4 2 1 0 2 2 2 1 Striatin family WD40 PF00400.27 EFE37426.1 - 3.8e-32 108.9 18.6 3.1e-06 26.8 0.0 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EFE37426.1 - 0.1 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 EFE37426.1 - 0.14 10.4 0.0 0.29 9.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain PAT1 PF09770.4 EFE37426.1 - 0.91 7.6 23.5 1.3 7.2 16.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Blt1 PF12754.2 EFE37427.1 - 1.5e-50 172.5 0.0 2e-50 172.1 0.0 1.2 1 0 0 1 1 1 1 Cell-cycle control medial ring component Nol1_Nop2_Fmu PF01189.12 EFE37428.1 - 4.2e-95 318.3 0.0 6.7e-95 317.7 0.0 1.3 1 0 0 1 1 1 1 NOL1/NOP2/sun family FtsJ PF01728.14 EFE37428.1 - 0.004 17.1 0.0 0.0074 16.2 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase UAA PF08449.6 EFE37429.1 - 1.8e-12 46.7 21.1 2.4e-12 46.4 14.7 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 EFE37429.1 - 5e-11 42.4 6.0 5e-11 42.4 4.2 3.0 1 1 2 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 EFE37429.1 - 0.0032 17.4 5.1 0.0032 17.4 3.5 2.4 2 0 0 2 2 2 1 EamA-like transporter family DUF2431 PF10354.4 EFE37430.1 - 4.9e-46 156.7 0.0 3.5e-29 101.8 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF2431) p47_phox_C PF08944.6 EFE37430.1 - 0.14 12.4 0.3 0.14 12.4 0.2 2.3 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain Nucleo_P87 PF07267.6 EFE37430.1 - 3.8 6.0 6.8 5.9 5.4 4.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF3987 PF13148.1 EFE37430.1 - 5.3 5.4 8.0 0.76 8.2 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) CLTH PF10607.4 EFE37431.1 - 3.2e-34 117.6 0.6 5.5e-34 116.9 0.1 1.6 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain INCA1 PF15142.1 EFE37431.1 - 0.039 13.7 0.1 0.082 12.7 0.0 1.5 1 0 0 1 1 1 0 INCA1 DKCLD PF08068.7 EFE37432.1 - 3.7e-30 103.6 0.1 3.1e-29 100.6 0.1 2.4 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 EFE37432.1 - 8.5e-24 84.4 0.2 6.6e-21 75.0 0.1 3.4 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 EFE37432.1 - 1.1e-20 73.0 1.2 2.1e-20 72.1 0.9 1.5 1 0 0 1 1 1 1 PUA domain CAF-1_p150 PF11600.3 EFE37432.1 - 0.0038 16.6 26.8 0.0056 16.0 18.6 1.2 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF4407 PF14362.1 EFE37432.1 - 0.47 9.3 11.2 0.69 8.8 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MRP-S26 PF14943.1 EFE37432.1 - 2.1 7.8 18.9 4.2 6.8 13.1 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Metaviral_G PF09595.5 EFE37432.1 - 2.9 7.5 9.0 4.7 6.8 6.2 1.2 1 0 0 1 1 1 0 Metaviral_G glycoprotein RNase_H2-Ydr279 PF09468.5 EFE37432.1 - 3.9 6.5 17.8 6.1 5.9 12.3 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DER1 PF04511.10 EFE37433.1 - 3.2e-21 75.7 0.6 5.6e-21 74.9 0.4 1.3 1 1 0 1 1 1 1 Der1-like family Rhomboid PF01694.17 EFE37433.1 - 0.24 11.4 7.0 1.3 9.0 4.8 2.0 1 1 0 1 1 1 0 Rhomboid family Abhydrolase_3 PF07859.8 EFE37434.1 - 9.6e-44 149.4 0.0 1.7e-41 142.1 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EFE37434.1 - 7.4e-05 21.6 0.3 0.00057 18.7 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.4 EFE37434.1 - 0.11 11.7 0.1 2.1 7.5 0.1 2.1 2 0 0 2 2 2 0 Esterase PHB depolymerase MaoC_dehydratas PF01575.14 EFE37435.1 - 0.0026 17.1 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain PDT PF00800.13 EFE37436.1 - 4.5e-63 212.0 0.1 5.9e-63 211.7 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.20 EFE37436.1 - 2.6e-05 23.6 0.0 8.3e-05 21.9 0.0 1.9 1 1 0 1 1 1 1 ACT domain Glyco_hydro_67N PF03648.9 EFE37436.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus eRF1_2 PF03464.10 EFE37437.1 - 3e-46 157.0 0.1 6e-46 156.0 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 EFE37437.1 - 4.5e-39 133.2 0.2 9.3e-39 132.1 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 EFE37437.1 - 1.5e-28 99.0 0.0 2.8e-28 98.1 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 DUF3321 PF11968.3 EFE37438.1 - 1.1e-89 299.8 0.0 1.3e-89 299.5 0.0 1.0 1 0 0 1 1 1 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 EFE37438.1 - 0.0059 16.3 0.0 0.0084 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ribosomal_L23 PF00276.15 EFE37439.1 - 4.6e-14 52.1 1.1 8.5e-14 51.2 0.7 1.5 1 1 0 1 1 1 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.8 EFE37439.1 - 0.03 14.3 1.8 0.03 14.3 1.2 2.7 1 1 1 2 2 2 0 Ribosomal protein L23, N-terminal domain Fork_head PF00250.13 EFE37440.1 - 2e-34 117.5 0.1 3.5e-34 116.6 0.0 1.4 1 0 0 1 1 1 1 Fork head domain G10 PF01125.12 EFE37441.1 - 3.6e-59 198.4 2.3 5.2e-59 197.9 1.6 1.2 1 0 0 1 1 1 1 G10 protein Potass_KdpF PF09604.5 EFE37441.1 - 7.4 6.5 7.8 2.9 7.8 0.6 2.3 2 0 0 2 2 2 0 F subunit of K+-transporting ATPase (Potass_KdpF) AA_kinase PF00696.23 EFE37442.1 - 1.1e-36 126.6 0.1 2.1e-36 125.7 0.1 1.5 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.1 EFE37442.1 - 3.9e-13 48.6 1.1 4.4e-11 42.1 0.1 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.20 EFE37442.1 - 1e-12 47.2 0.3 1.5e-10 40.3 0.1 2.8 2 0 0 2 2 2 2 ACT domain Peptidase_C78 PF07910.8 EFE37443.1 - 2.7e-37 128.0 0.4 4e-32 111.1 0.1 2.2 1 1 1 2 2 2 2 Peptidase family C78 zf-Di19 PF05605.7 EFE37443.1 - 0.00031 20.7 3.6 0.027 14.5 0.8 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 EFE37443.1 - 0.06 13.7 2.0 4.3 7.8 0.7 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.1 EFE37443.1 - 0.14 12.4 0.5 0.32 11.3 0.3 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain AAA_18 PF13238.1 EFE37444.1 - 1.4e-12 48.0 1.4 6.4e-12 45.8 0.2 2.2 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 EFE37444.1 - 2.3e-10 41.3 0.2 6.6e-10 39.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 EFE37444.1 - 0.00029 21.0 0.0 0.00054 20.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 EFE37444.1 - 0.00065 19.7 0.9 0.0013 18.6 0.6 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFE37444.1 - 0.0013 18.8 0.1 0.002 18.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 EFE37444.1 - 0.0014 17.8 0.0 0.0043 16.2 0.0 1.8 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_16 PF13191.1 EFE37444.1 - 0.002 18.1 0.2 0.0053 16.7 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_10 PF12846.2 EFE37444.1 - 0.0031 17.0 0.3 0.024 14.0 0.2 1.9 1 1 0 1 1 1 1 AAA-like domain AAA_14 PF13173.1 EFE37444.1 - 0.0031 17.4 0.3 0.0083 16.0 0.2 2.0 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 EFE37444.1 - 0.0044 16.7 0.1 0.011 15.5 0.0 1.7 2 0 0 2 2 2 1 NTPase ADK PF00406.17 EFE37444.1 - 0.0062 16.4 0.2 0.039 13.8 0.0 2.2 1 1 0 2 2 2 1 Adenylate kinase AAA_33 PF13671.1 EFE37444.1 - 0.0065 16.3 0.0 0.0096 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EFE37444.1 - 0.024 14.7 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Cytidylate_kin2 PF13189.1 EFE37444.1 - 0.025 14.5 0.1 0.045 13.6 0.1 1.7 1 1 0 1 1 1 0 Cytidylate kinase-like family IstB_IS21 PF01695.12 EFE37444.1 - 0.044 13.1 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein KaiC PF06745.8 EFE37444.1 - 0.066 12.3 0.8 0.17 11.0 0.1 1.9 1 1 1 2 2 2 0 KaiC AAA_3 PF07726.6 EFE37444.1 - 0.079 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EFE37444.1 - 0.091 12.4 0.1 0.64 9.6 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.12 EFE37444.1 - 0.14 11.6 0.4 0.62 9.5 0.0 2.0 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Ham1p_like PF01725.11 EFE37445.1 - 2.1e-30 105.5 0.0 2.4e-30 105.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Myosin_head PF00063.16 EFE37446.1 - 6.5e-246 817.6 2.5 1e-245 817.0 1.8 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.14 EFE37446.1 - 7e-18 64.4 0.2 2.6e-17 62.6 0.1 2.1 1 1 0 1 1 1 1 DIL domain IQ PF00612.22 EFE37446.1 - 5.1e-12 44.2 32.1 6.2e-05 22.2 0.4 6.8 6 0 0 6 6 6 4 IQ calmodulin-binding motif GAS PF13851.1 EFE37446.1 - 0.00063 18.9 12.4 0.00063 18.9 8.6 2.8 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding AAA_22 PF13401.1 EFE37446.1 - 0.0015 18.6 2.3 0.0033 17.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFE37446.1 - 0.0044 17.0 0.5 0.12 12.2 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain Fez1 PF06818.10 EFE37446.1 - 0.0046 17.0 16.0 0.0046 17.0 11.1 1.9 2 0 0 2 2 2 1 Fez1 T2SE PF00437.15 EFE37446.1 - 0.0065 15.3 0.0 0.015 14.2 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Myosin_N PF02736.14 EFE37446.1 - 0.012 15.2 2.9 0.029 14.0 2.0 1.6 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_19 PF13245.1 EFE37446.1 - 0.022 14.5 0.0 0.062 13.0 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_10 PF12846.2 EFE37446.1 - 0.042 13.2 1.4 0.14 11.6 0.0 2.5 3 1 0 3 3 3 0 AAA-like domain DUF258 PF03193.11 EFE37446.1 - 0.049 12.8 0.0 0.14 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 RNA_helicase PF00910.17 EFE37446.1 - 0.075 13.2 0.0 0.3 11.2 0.0 2.1 1 0 0 1 1 1 0 RNA helicase FlaC_arch PF05377.6 EFE37446.1 - 0.12 12.3 6.5 0.62 9.9 0.1 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 EFE37446.1 - 0.19 10.8 3.0 0.41 9.7 2.1 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein IncA PF04156.9 EFE37446.1 - 0.27 10.8 28.3 0.55 9.7 5.4 2.6 1 1 1 2 2 2 0 IncA protein Baculo_PEP_C PF04513.7 EFE37446.1 - 0.79 9.5 10.5 0.27 11.0 3.6 2.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus WEMBL PF05701.6 EFE37446.1 - 1.1 7.5 23.9 6.1 5.1 16.6 1.9 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DegQ PF08181.6 EFE37446.1 - 2.3 8.0 11.6 0.029 14.0 0.8 3.1 3 0 0 3 3 3 0 DegQ (SacQ) family Fib_alpha PF08702.5 EFE37446.1 - 4.7 7.3 13.0 5.2 7.1 1.5 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family NAP PF00956.13 EFE37447.1 - 9e-86 286.9 7.7 9e-86 286.9 5.3 2.2 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Sigma70_ner PF04546.8 EFE37447.1 - 0.71 9.4 23.6 0.77 9.3 1.3 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region TFIIA PF03153.8 EFE37447.1 - 3.5 7.4 26.0 3.3 7.5 8.3 2.4 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.6 EFE37447.1 - 6 4.5 9.1 19 2.9 0.0 2.2 2 0 0 2 2 2 0 Sporozoite P67 surface antigen HhH-GPD PF00730.20 EFE37448.1 - 5.4e-08 33.0 0.0 6e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF4332 PF14229.1 EFE37448.1 - 0.018 15.0 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Fasciclin PF02469.17 EFE37449.1 - 2.4e-32 111.6 0.1 2.7e-17 62.9 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain NEAT PF05031.7 EFE37449.1 - 0.051 13.5 0.0 3.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Iron Transport-associated domain G_glu_transpept PF01019.16 EFE37450.1 - 5.4e-149 496.9 0.0 6.1e-149 496.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RasGEF PF00617.14 EFE37451.1 - 5.2e-55 186.0 0.3 1e-54 185.1 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EFE37451.1 - 1.5e-16 60.3 0.0 4.6e-16 58.8 0.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.1 EFE37451.1 - 1.5e-06 27.7 0.0 3.6e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFE37451.1 - 2.9e-05 23.3 0.0 8.3e-05 21.9 0.0 1.9 1 0 0 1 1 1 1 SH3 domain HATPase_c_3 PF13589.1 EFE37452.1 - 4.9e-19 68.3 0.0 8.8e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.6 EFE37452.1 - 1.1e-10 41.2 0.0 8.7e-10 38.3 0.0 2.1 2 0 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.21 EFE37452.1 - 1.8e-06 27.6 0.0 3.4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Late_protein_L1 PF00500.13 EFE37454.1 - 0.074 11.5 0.0 0.096 11.2 0.0 1.1 1 0 0 1 1 1 0 L1 (late) protein Ninjurin PF04923.7 EFE37454.1 - 0.16 11.6 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Ninjurin Fungal_trans_2 PF11951.3 EFE37455.1 - 0.0005 18.7 4.3 0.0042 15.7 0.4 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain MBOAT_2 PF13813.1 EFE37456.1 - 8e-15 54.6 6.7 9.1e-15 54.5 2.9 2.4 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family RTA1 PF04479.8 EFE37459.1 - 1.5e-44 152.1 12.9 1.5e-44 152.1 9.0 1.5 2 0 0 2 2 2 1 RTA1 like protein DUF1349 PF07081.6 EFE37460.1 - 1.6e-21 76.5 0.0 5.1e-20 71.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) MFS_1 PF07690.11 EFE37461.1 - 8.5e-22 77.3 39.9 3.9e-20 71.8 27.6 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2530 PF10745.4 EFE37461.1 - 0.014 15.4 0.2 0.092 12.7 0.1 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2530) p450 PF00067.17 EFE37462.1 - 6e-34 117.3 0.0 6.7e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 VWA PF00092.23 EFE37463.1 - 9.5e-15 54.7 0.0 1.3e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 EFE37463.1 - 3.7e-14 53.2 0.0 4.6e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.1 EFE37463.1 - 1.7e-08 34.3 0.1 2.3e-06 27.3 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.9 EFE37463.1 - 0.075 12.1 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Vint PF14623.1 EFE37464.1 - 3.2e-55 186.0 0.0 6.6e-55 185.0 0.0 1.5 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.1 EFE37464.1 - 1.8e-12 47.1 0.0 5.5e-05 23.1 0.0 2.5 1 1 1 2 2 2 2 VWA / Hh protein intein-like Hint_2 PF13403.1 EFE37464.1 - 0.13 12.1 0.1 0.42 10.5 0.0 1.9 2 0 0 2 2 2 0 Hint domain ABC_membrane PF00664.18 EFE37465.1 - 1.8e-83 280.1 23.7 2e-45 155.3 7.2 3.0 2 1 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE37465.1 - 5.4e-67 224.3 0.0 8e-33 113.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE37465.1 - 6.5e-13 48.4 0.4 0.00024 20.4 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE37465.1 - 4.2e-12 46.6 0.0 0.07 13.0 0.0 4.3 3 1 1 4 4 4 3 AAA domain AAA_16 PF13191.1 EFE37465.1 - 4.1e-08 33.4 3.3 0.00022 21.2 0.0 3.3 2 1 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 EFE37465.1 - 4.9e-08 33.8 0.0 0.0062 17.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFE37465.1 - 1.7e-07 30.6 3.5 0.00041 19.8 0.1 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 EFE37465.1 - 9.1e-07 27.8 0.4 0.042 12.4 0.0 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class DUF258 PF03193.11 EFE37465.1 - 1.1e-06 27.9 0.0 0.049 12.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFE37465.1 - 4.4e-06 26.8 0.3 0.11 12.6 0.0 3.5 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EFE37465.1 - 0.00011 22.5 0.1 0.57 10.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.1 EFE37465.1 - 0.00017 21.2 1.0 1.3 8.5 0.0 3.9 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.1 EFE37465.1 - 0.00045 20.1 0.2 1.2 9.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EFE37465.1 - 0.00055 19.6 0.5 0.29 10.8 0.0 3.5 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 EFE37465.1 - 0.00069 19.0 0.4 1.1 8.6 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA PF00004.24 EFE37465.1 - 0.00078 19.6 0.8 1.2 9.2 0.0 3.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFE37465.1 - 0.0011 18.7 0.2 2.2 8.0 0.0 2.9 2 0 0 2 2 2 2 Part of AAA domain SbcCD_C PF13558.1 EFE37465.1 - 0.0014 18.5 3.3 0.34 10.8 0.5 3.7 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit SRP54 PF00448.17 EFE37465.1 - 0.0017 17.7 0.1 1.9 7.9 0.0 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_14 PF13173.1 EFE37465.1 - 0.0018 18.1 0.0 4.9 7.0 0.0 3.9 4 0 0 4 4 4 0 AAA domain AAA_23 PF13476.1 EFE37465.1 - 0.0021 18.3 0.3 0.46 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EFE37465.1 - 0.0036 16.4 0.2 1.1 8.3 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin MobB PF03205.9 EFE37465.1 - 0.0077 15.9 0.1 5.9 6.5 0.0 2.8 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 EFE37465.1 - 0.011 15.1 0.4 9.5 5.5 0.0 3.1 3 0 0 3 3 3 0 AAA-like domain AAA_28 PF13521.1 EFE37465.1 - 0.015 15.2 2.0 3 7.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.20 EFE37465.1 - 0.016 14.7 2.1 2.7 7.4 0.0 4.1 4 1 0 4 4 4 0 ATP synthase alpha/beta family, nucleotide-binding domain G-alpha PF00503.15 EFE37465.1 - 0.03 13.0 0.0 1.6 7.2 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Rad17 PF03215.10 EFE37465.1 - 0.038 12.6 0.0 0.21 10.2 0.0 1.9 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein MMR_HSR1 PF01926.18 EFE37465.1 - 0.048 13.6 0.3 19 5.2 0.0 3.1 3 0 0 3 3 2 0 50S ribosome-binding GTPase NB-ARC PF00931.17 EFE37465.1 - 0.092 11.5 0.7 4.2 6.1 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.17 EFE37465.1 - 0.11 12.6 0.6 7.1 6.8 0.0 3.0 3 0 0 3 3 3 0 RNA helicase PRK PF00485.13 EFE37465.1 - 0.13 11.8 0.2 4.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_15 PF13175.1 EFE37465.1 - 0.18 10.8 0.0 4.4 6.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF3722 PF12519.3 EFE37466.1 - 3e-81 272.4 0.3 3.7e-81 272.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) TIM PF00121.13 EFE37467.1 - 2.3e-89 298.6 0.5 2.6e-89 298.4 0.4 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase PhyH PF05721.8 EFE37468.1 - 9.3e-33 114.0 0.0 1.1e-32 113.7 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) MFS_1 PF07690.11 EFE37469.1 - 3.5e-17 62.1 12.1 3.5e-17 62.1 8.4 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2423 PF10338.4 EFE37469.1 - 0.37 10.8 1.0 0.55 10.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2423) Amidase PF01425.16 EFE37470.1 - 4e-74 250.0 0.0 7.4e-74 249.1 0.0 1.4 1 1 0 1 1 1 1 Amidase DUF4185 PF13810.1 EFE37471.1 - 5.3e-05 22.2 0.3 7.7e-05 21.7 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) Kelch_5 PF13854.1 EFE37471.1 - 0.042 13.8 0.9 0.21 11.5 0.0 2.6 3 0 0 3 3 3 0 Kelch motif BMC PF00936.14 EFE37471.1 - 0.047 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 BMC domain RRM_5 PF13893.1 EFE37472.1 - 4.1e-06 26.5 0.0 6.7e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE37472.1 - 0.00022 20.7 0.0 0.00033 20.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE37472.1 - 0.026 14.5 0.0 0.065 13.2 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Tachystatin_B PF11478.3 EFE37472.1 - 0.12 12.1 2.8 0.85 9.3 2.1 2.0 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B zf-CCCH PF00642.19 EFE37472.1 - 0.16 11.6 7.5 0.19 11.4 3.2 2.2 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UDPGP PF01704.13 EFE37474.1 - 3.9e-181 602.1 0.1 4.4e-181 601.9 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PilO PF04350.8 EFE37474.1 - 0.073 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Pilus assembly protein, PilO LZ_Tnp_IS66 PF13007.2 EFE37475.1 - 0.027 15.1 5.5 0.027 15.1 3.8 1.9 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain NYN_YacP PF05991.6 EFE37475.1 - 0.17 11.6 0.5 0.27 10.9 0.3 1.3 1 0 0 1 1 1 0 YacP-like NYN domain RRM_1 PF00076.17 EFE37476.1 - 6.8e-17 60.8 0.0 1.2e-11 44.0 0.0 3.0 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE37476.1 - 1.6e-14 53.5 0.0 6.7e-10 38.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE37476.1 - 1.6e-13 50.2 0.0 1.3e-05 24.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EFE37476.1 - 0.00073 19.2 0.0 0.21 11.3 0.0 3.0 3 0 0 3 3 3 2 Limkain b1 MFS_1 PF07690.11 EFE37477.1 - 1.1e-07 30.8 56.5 0.00051 18.8 19.1 3.7 2 1 1 4 4 4 3 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37477.1 - 0.00037 19.1 12.4 0.00037 19.1 8.6 3.2 2 1 1 3 3 3 1 Sugar (and other) transporter DUF4407 PF14362.1 EFE37477.1 - 2.8 6.8 5.7 7.3 5.4 3.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NRDE PF05742.7 EFE37478.1 - 4.3e-34 118.0 0.0 9.4e-34 116.9 0.0 1.4 1 1 0 1 1 1 1 NRDE protein BPL_N PF09825.4 EFE37479.1 - 3.4e-123 411.0 0.0 7.4e-123 409.9 0.0 1.5 2 0 0 2 2 2 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.14 EFE37479.1 - 2.1e-19 69.7 0.0 4.1e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.12 EFE37479.1 - 8e-05 22.2 0.0 0.0002 21.0 0.0 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain Mgm101p PF06420.7 EFE37480.1 - 2.7e-91 303.5 0.0 3.6e-91 303.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 eIF-1a PF01176.14 EFE37480.1 - 0.16 11.3 0.2 0.33 10.3 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 zf-RING_2 PF13639.1 EFE37481.1 - 1.1e-14 53.9 5.9 1.9e-14 53.2 4.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFE37481.1 - 5.7e-08 32.2 2.1 9.6e-08 31.5 1.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE37481.1 - 1.1e-07 31.7 4.5 2e-07 30.9 3.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFE37481.1 - 1.9e-07 31.0 0.6 3.6e-07 30.1 0.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 EFE37481.1 - 1.6e-06 27.6 2.0 3.3e-06 26.6 1.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE37481.1 - 3.5e-06 26.6 2.0 6.3e-06 25.8 1.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 EFE37481.1 - 0.00037 20.2 1.5 0.00072 19.3 1.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 EFE37481.1 - 0.0039 16.7 2.3 0.0077 15.7 1.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain PHD PF00628.24 EFE37481.1 - 0.48 10.1 2.6 1.1 9.0 1.8 1.7 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.3 EFE37481.1 - 0.5 10.3 3.8 3 7.8 2.6 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.1 EFE37481.1 - 0.57 9.9 2.7 4 7.2 2.2 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 TMEM154 PF15102.1 EFE37481.1 - 0.76 9.4 0.0 0.76 9.4 0.0 2.6 3 0 0 3 3 3 0 TMEM154 protein family zf-C3HC4_4 PF15227.1 EFE37481.1 - 0.81 9.6 5.2 1.7 8.5 3.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Toxin_49 PF15529.1 EFE37481.1 - 1.4 8.8 7.9 5.7 6.9 0.3 3.7 3 0 0 3 3 3 0 Putative toxin 49 NLPC_P60 PF00877.14 EFE37482.1 - 1.1e-07 31.5 0.0 1.6e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 NlpC/P60 family Phage_lysozyme PF00959.14 EFE37483.1 - 1.1e-12 48.2 0.0 1.4e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme SelB-wing_2 PF09106.6 EFE37484.1 - 0.11 12.3 0.7 0.22 11.4 0.5 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix MS_channel PF00924.13 EFE37486.1 - 2e-18 66.5 0.5 4.1e-18 65.4 0.3 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel FA_desaturase PF00487.19 EFE37486.1 - 0.026 13.9 9.3 0.23 10.8 2.5 2.4 2 0 0 2 2 2 0 Fatty acid desaturase EF-hand_1 PF00036.27 EFE37486.1 - 0.079 12.3 1.5 0.11 11.7 0.2 2.0 2 0 0 2 2 2 0 EF hand Pkinase PF00069.20 EFE37487.1 - 5.1e-23 81.5 0.0 8.2e-23 80.8 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37487.1 - 7.8e-05 21.8 0.0 0.00012 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE37487.1 - 0.0038 16.3 0.0 0.0053 15.8 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE37487.1 - 0.081 12.6 0.0 1.7 8.3 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family EcKinase PF02958.15 EFE37487.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Aminotran_1_2 PF00155.16 EFE37489.1 - 1.6e-78 264.1 0.0 2e-78 263.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Syntaxin-18_N PF10496.4 EFE37491.1 - 2.1e-13 49.9 0.6 2e-12 46.7 0.0 2.7 2 1 1 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.14 EFE37491.1 - 8.4e-06 25.3 1.5 3.7e-05 23.3 0.5 2.3 2 0 0 2 2 2 1 SNARE domain TPR_1 PF00515.23 EFE37492.1 - 3.6e-14 51.6 6.9 2.4e-07 30.0 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFE37492.1 - 6.9e-14 50.5 5.7 1.3e-05 24.7 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 EFE37492.1 - 3.9e-12 45.6 5.7 5.4e-10 38.7 0.3 3.2 3 0 0 3 3 3 2 TPR repeat PB1 PF00564.19 EFE37492.1 - 2.3e-08 33.5 0.1 4.4e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 PB1 domain TPR_12 PF13424.1 EFE37492.1 - 3.7e-08 33.1 1.1 3.4e-05 23.7 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFE37492.1 - 4e-08 32.4 1.5 0.0032 17.1 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE37492.1 - 7.5e-07 28.4 1.0 3.1e-05 23.4 0.1 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFE37492.1 - 2.1e-05 24.6 0.3 2.2 8.9 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE37492.1 - 3.6e-05 24.3 2.0 0.0036 17.9 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFE37492.1 - 4.3e-05 23.3 1.2 0.0025 17.9 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EFE37492.1 - 0.0003 20.5 0.2 1 9.2 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFE37492.1 - 0.0016 18.8 2.7 0.076 13.6 0.0 3.5 2 1 2 4 4 3 1 Tetratricopeptide repeat TPR_5 PF12688.2 EFE37492.1 - 0.035 14.1 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Tetratrico peptide repeat Apc3 PF12895.2 EFE37492.1 - 0.093 12.8 3.3 0.24 11.5 0.1 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Sod_Cu PF00080.15 EFE37493.1 - 2.1e-10 40.9 0.0 2.6e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Pkinase PF00069.20 EFE37494.1 - 7.2e-62 208.8 0.0 1.5e-61 207.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37494.1 - 2.9e-26 92.1 0.0 4.7e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE37494.1 - 0.0027 16.7 0.0 0.0059 15.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE37494.1 - 0.11 12.2 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family CDC45 PF02724.9 EFE37494.1 - 1.8 6.5 5.4 2.3 6.1 3.7 1.1 1 0 0 1 1 1 0 CDC45-like protein CMV_1a PF12467.3 EFE37494.1 - 6.7 7.0 11.0 16 5.8 7.6 1.5 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family RXT2_N PF08595.6 EFE37495.1 - 6.6 6.5 10.3 4.1 7.1 3.2 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal AMP-binding PF00501.23 EFE37496.1 - 2.8e-242 803.4 0.0 4.7e-83 278.9 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.15 EFE37496.1 - 4.9e-131 436.0 0.0 1.1e-44 152.5 0.0 4.5 4 1 0 4 4 4 4 Condensation domain PP-binding PF00550.20 EFE37496.1 - 2.8e-37 126.8 2.2 2.2e-11 43.8 0.0 4.6 4 0 0 4 4 4 3 Phosphopantetheine attachment site NAD_binding_4 PF07993.7 EFE37496.1 - 1.2e-36 125.9 0.0 2e-36 125.1 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding_C PF13193.1 EFE37496.1 - 6.7e-15 55.8 0.0 0.00023 22.0 0.0 3.9 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Epimerase PF01370.16 EFE37496.1 - 1.9e-09 37.3 0.0 4e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AATase PF07247.7 EFE37496.1 - 0.1 11.1 0.0 30 2.9 0.0 4.2 5 1 1 6 6 6 0 Alcohol acetyltransferase 3Beta_HSD PF01073.14 EFE37496.1 - 0.11 11.1 0.0 0.22 10.2 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Usp PF00582.21 EFE37497.1 - 6.2e-12 45.8 1.1 1e-05 25.7 0.1 2.7 1 1 1 2 2 2 2 Universal stress protein family DUF1510 PF07423.6 EFE37499.1 - 0.0003 20.2 2.2 0.00043 19.7 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) SpoIIIAH PF12685.2 EFE37499.1 - 0.13 11.7 4.3 0.21 11.0 3.0 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Packaging_FI PF14000.1 EFE37499.1 - 1.2 9.3 7.8 3 8.0 0.0 2.5 2 1 0 2 2 2 0 DNA packaging protein FI DUF3827 PF12877.2 EFE37499.1 - 1.9 6.5 7.5 2.5 6.0 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) BUD22 PF09073.5 EFE37499.1 - 2.6 7.0 14.5 3.8 6.4 10.0 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.7 EFE37499.1 - 5.8 4.6 8.8 7.6 4.3 6.1 1.0 1 0 0 1 1 1 0 Nop14-like family FAM220 PF15487.1 EFE37499.1 - 7 5.9 10.7 4.6 6.5 6.2 1.5 2 0 0 2 2 2 0 FAM220 family SNF2_N PF00176.18 EFE37500.1 - 1.3e-71 240.8 0.0 2.1e-71 240.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE37500.1 - 4.5e-14 52.0 0.0 1e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EFE37500.1 - 1.6e-06 27.1 0.0 4.2e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 G0-G1_switch_2 PF15103.1 EFE37501.1 - 0.2 11.8 2.7 0.28 11.4 1.9 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 Pkinase PF00069.20 EFE37503.1 - 1.4e-39 135.8 3.0 3.5e-24 85.3 1.1 2.8 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37503.1 - 3e-15 55.9 7.5 4.9e-13 48.7 1.2 2.9 3 1 1 4 4 4 2 Protein tyrosine kinase RIO1 PF01163.17 EFE37503.1 - 0.034 13.4 0.4 0.14 11.5 0.3 1.9 1 1 0 1 1 1 0 RIO1 family APH PF01636.18 EFE37503.1 - 0.04 13.6 2.7 0.075 12.7 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family eIF-3c_N PF05470.7 EFE37504.1 - 3.2e-170 567.1 26.1 1.2e-136 456.3 1.9 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 EFE37504.1 - 7.5e-14 51.9 1.4 4e-12 46.3 0.0 3.6 2 1 1 3 3 3 1 PCI domain Daxx PF03344.10 EFE37504.1 - 9.3 4.5 25.2 16 3.8 17.5 1.3 1 0 0 1 1 1 0 Daxx Family EAP30 PF04157.11 EFE37505.1 - 7.9e-57 191.9 0.0 9.5e-57 191.7 0.0 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family MarR_2 PF12802.2 EFE37505.1 - 0.072 12.7 0.2 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 MarR family Ribosomal_L30 PF00327.15 EFE37506.1 - 1.5e-18 66.1 3.1 2.4e-18 65.4 1.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 EFE37506.1 - 1.6e-18 66.4 2.5 3.1e-18 65.5 1.7 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Endonuc_BglI PF14562.1 EFE37506.1 - 0.071 11.9 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease BglI DNA_pol_B PF00136.16 EFE37507.1 - 3.3e-114 382.2 1.3 5.3e-114 381.5 0.9 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 EFE37507.1 - 1.8e-65 219.8 0.9 3.1e-65 219.0 0.1 1.9 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 EFE37507.1 - 2.1e-42 145.1 0.0 5e-42 143.9 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.3 EFE37507.1 - 1.7e-24 85.4 11.6 1.7e-24 85.4 8.0 2.3 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal HSP70 PF00012.15 EFE37508.1 - 1.3e-262 872.1 16.3 1.4e-262 871.9 11.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFE37508.1 - 9.7e-15 53.9 6.4 6.8e-13 47.9 1.6 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 EFE37508.1 - 0.00014 21.5 0.0 0.00037 20.1 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 EFE37508.1 - 0.016 15.0 11.1 1.1 9.1 1.4 4.6 2 2 1 3 3 3 0 Cell division protein FtsA Hydantoinase_A PF01968.13 EFE37508.1 - 0.057 12.5 4.1 1.8 7.6 0.0 3.4 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase DUF2415 PF10313.4 EFE37509.1 - 4.8e-16 58.1 0.0 1.3e-15 56.7 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.27 EFE37509.1 - 0.014 15.2 0.3 4.5 7.3 0.1 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF1646 PF07854.7 EFE37510.1 - 0.024 13.7 4.7 0.048 12.7 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1646) DSHCT PF08148.7 EFE37511.1 - 1.2e-60 203.8 0.7 2.2e-60 203.0 0.5 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 EFE37511.1 - 9.3e-19 67.5 0.0 1.9e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE37511.1 - 2.8e-06 27.0 0.0 6.5e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE37511.1 - 0.11 12.3 0.0 1.8 8.3 0.0 2.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit BRCA2 PF00634.13 EFE37511.1 - 0.16 11.2 2.8 0.23 10.7 0.1 2.4 2 0 0 2 2 2 0 BRCA2 repeat IBN_N PF03810.14 EFE37512.1 - 3.7e-15 55.5 0.8 7.2e-13 48.2 0.0 4.4 5 0 0 5 5 5 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 EFE37512.1 - 3.5e-07 30.4 0.0 0.0078 16.4 0.0 2.9 2 0 0 2 2 2 2 HEAT repeats Cse1 PF08506.5 EFE37512.1 - 1.2e-06 27.3 0.0 2.6e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Cse1 Xpo1 PF08389.7 EFE37512.1 - 0.00037 20.4 1.2 0.016 15.1 0.0 3.5 3 0 0 3 3 3 1 Exportin 1-like protein DUF2435 PF10363.4 EFE37512.1 - 0.0027 17.5 0.2 0.012 15.5 0.1 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2435) HEAT_EZ PF13513.1 EFE37512.1 - 0.053 14.0 0.5 2 8.9 0.0 3.9 3 0 0 3 3 3 0 HEAT-like repeat GRIP PF01465.15 EFE37512.1 - 0.099 12.1 0.5 0.93 9.0 0.1 3.0 2 1 1 3 3 3 0 GRIP domain Vac14_Fab1_bd PF12755.2 EFE37512.1 - 0.31 11.4 1.0 1.9 8.8 0.0 3.0 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region RRM_1 PF00076.17 EFE37513.1 - 1.5e-08 34.1 0.0 3.1e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE37513.1 - 2e-07 30.9 0.0 3.3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE37513.1 - 0.0006 19.5 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif BLVR PF06375.6 EFE37514.1 - 0.94 9.2 21.7 0.62 9.8 10.4 2.8 2 1 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) DbpA PF03880.10 EFE37515.1 - 0.0023 17.5 0.0 0.0045 16.6 0.0 1.5 1 0 0 1 1 1 1 DbpA RNA binding domain RRM_5 PF13893.1 EFE37515.1 - 0.022 14.6 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.11 EFE37516.1 - 1.7e-23 82.8 24.8 4.8e-22 78.1 6.3 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37516.1 - 1e-09 37.4 4.1 1e-09 37.4 2.8 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter DUF791 PF05631.9 EFE37516.1 - 0.0023 16.7 0.1 0.0041 15.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF791) Folate_carrier PF01770.13 EFE37516.1 - 0.074 11.5 3.7 0.48 8.8 0.1 2.2 2 0 0 2 2 2 0 Reduced folate carrier Kinetocho_Slk19 PF12709.2 EFE37517.1 - 3.2e-21 75.1 28.3 6e-21 74.3 4.3 4.5 3 1 2 5 5 5 2 Central kinetochore-associated IncA PF04156.9 EFE37517.1 - 0.0084 15.7 23.4 0.14 11.7 3.9 2.5 2 0 0 2 2 2 2 IncA protein WEMBL PF05701.6 EFE37517.1 - 0.44 8.9 43.2 5.5 5.3 29.5 2.0 1 1 0 1 1 1 0 Weak chloroplast movement under blue light AAA_13 PF13166.1 EFE37517.1 - 1.1 7.5 25.2 0.19 10.1 4.9 2.6 1 1 0 2 2 2 0 AAA domain Filament PF00038.16 EFE37517.1 - 1.6 8.1 31.3 0.17 11.3 2.6 3.2 1 1 0 1 1 1 0 Intermediate filament protein GAS PF13851.1 EFE37517.1 - 2.3 7.3 28.3 4.5 6.4 6.5 2.8 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.7 EFE37517.1 - 5.2 6.8 18.5 0.33 10.7 3.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) FAD_binding_3 PF01494.14 EFE37518.1 - 3.4e-11 42.7 0.1 1.6e-10 40.5 0.0 2.1 2 1 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 EFE37518.1 - 0.00015 20.8 0.4 0.038 12.8 0.0 3.0 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFE37518.1 - 0.00018 21.4 0.3 0.018 15.0 0.0 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFE37518.1 - 0.0014 18.4 0.0 0.11 12.3 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.19 EFE37518.1 - 0.0024 16.8 0.2 0.0043 16.0 0.1 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.5 EFE37518.1 - 0.18 10.5 0.0 0.29 9.9 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase Fungal_trans PF04082.13 EFE37519.1 - 3e-35 121.3 0.9 5.9e-35 120.3 0.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE37519.1 - 0.0039 17.0 18.0 0.0068 16.2 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sof1 PF04158.9 EFE37519.1 - 0.031 14.2 0.5 0.092 12.7 0.4 1.7 1 0 0 1 1 1 0 Sof1-like domain MFS_1 PF07690.11 EFE37520.1 - 8.3e-15 54.3 32.7 8.3e-15 54.3 22.6 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFE37520.1 - 1.6e-11 43.9 3.5 1.6e-11 43.9 2.4 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF373 PF04123.8 EFE37520.1 - 3 6.7 12.1 0.13 11.2 1.6 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF373) Amidohydro_4 PF13147.1 EFE37521.1 - 1.5e-12 48.1 0.2 1.3e-11 45.0 0.1 2.2 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EFE37521.1 - 3.4e-12 46.6 0.0 2.7e-11 43.6 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 EFE37521.1 - 1.5e-07 31.0 0.3 3.6e-07 29.7 0.1 1.7 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_5 PF13594.1 EFE37521.1 - 9.4e-07 28.5 0.2 1e-05 25.2 0.0 2.4 2 0 0 2 2 2 1 Amidohydrolase GMC_oxred_N PF00732.14 EFE37522.1 - 8e-48 163.0 0.0 1.1e-47 162.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFE37522.1 - 6.8e-37 126.9 0.0 1e-36 126.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 EFE37522.1 - 5.4e-07 28.8 0.2 0.00032 19.7 0.0 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFE37522.1 - 9e-05 21.4 0.0 0.13 11.1 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 EFE37522.1 - 0.0001 21.4 0.0 0.00015 20.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFE37522.1 - 0.00011 22.0 0.1 0.00036 20.4 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 EFE37522.1 - 0.013 14.1 0.0 0.019 13.6 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.2 EFE37522.1 - 0.017 14.1 0.0 0.22 10.5 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFE37522.1 - 0.019 14.8 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE37522.1 - 0.075 13.4 0.2 0.92 9.9 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Aldedh PF00171.17 EFE37523.1 - 1.4e-159 531.4 0.3 1.6e-159 531.1 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Glucosamine_iso PF01182.15 EFE37524.1 - 1.4e-13 51.0 0.0 2e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Glyco_hydro_3 PF00933.16 EFE37525.1 - 2.8e-59 200.5 0.0 5.1e-59 199.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFE37525.1 - 8.1e-08 32.0 0.0 1.8e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_1 PF00583.19 EFE37525.1 - 1.2e-05 25.2 0.0 3.8e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE37525.1 - 0.0011 19.1 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE37525.1 - 0.0069 16.5 0.0 0.019 15.1 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE37525.1 - 0.037 13.7 0.0 0.16 11.7 0.0 2.1 1 0 0 1 1 1 0 FR47-like protein Ribosomal_60s PF00428.14 EFE37525.1 - 6.8 7.1 17.6 0.99 9.8 1.4 2.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein NDT80_PhoG PF05224.7 EFE37527.1 - 2.3e-31 109.2 9.2 1.8e-20 73.7 0.0 3.9 4 0 0 4 4 4 2 NDT80 / PhoG like DNA-binding family DUF605 PF04652.11 EFE37527.1 - 0.49 9.7 33.9 1.7 7.9 8.5 2.1 2 0 0 2 2 2 0 Vta1 like Hexokinase_1 PF00349.16 EFE37528.1 - 2.2e-34 118.5 0.0 3.8e-34 117.8 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 EFE37528.1 - 3.4e-33 114.8 0.0 9e-26 90.5 0.0 2.3 2 0 0 2 2 2 2 Hexokinase Thioredox_DsbH PF03190.10 EFE37530.1 - 2.2e-39 134.8 0.0 3.7e-39 134.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 WD40 PF00400.27 EFE37531.1 - 7.1e-17 60.5 20.7 1e-05 25.2 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EFE37531.1 - 0.033 12.9 0.0 0.087 11.5 0.0 1.8 2 0 0 2 2 2 0 Nup133 N terminal like DUF1513 PF07433.6 EFE37531.1 - 0.04 12.8 0.2 0.79 8.5 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1513) DUF1902 PF08972.6 EFE37531.1 - 0.34 10.4 3.6 1 8.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1902) LSM14 PF12701.2 EFE37532.1 - 5.4e-25 87.0 0.0 1.4e-24 85.6 0.0 1.7 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.5 EFE37532.1 - 1.5e-16 60.8 5.2 1.5e-16 60.8 3.6 3.2 3 1 0 3 3 3 1 FDF domain GRP PF07172.6 EFE37532.1 - 0.95 9.9 26.7 7.6 7.0 0.7 2.9 2 0 0 2 2 2 0 Glycine rich protein family API5 PF05918.6 EFE37532.1 - 8 4.8 19.6 0.26 9.7 5.9 2.1 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) GP41 PF00517.12 EFE37533.1 - 0.015 14.8 0.8 0.023 14.2 0.6 1.2 1 0 0 1 1 1 0 Retroviral envelope protein CDC45 PF02724.9 EFE37533.1 - 0.016 13.2 2.4 0.016 13.2 1.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1754 PF08555.5 EFE37533.1 - 0.033 14.7 5.1 0.058 13.9 3.5 1.4 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Sporozoite_P67 PF05642.6 EFE37533.1 - 0.049 11.5 2.2 0.055 11.3 1.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.7 EFE37533.1 - 0.059 11.2 6.8 0.06 11.2 4.7 1.2 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.6 EFE37533.1 - 0.082 12.4 7.8 0.13 11.7 5.4 1.2 1 0 0 1 1 1 0 PPP4R2 DUF2890 PF11081.3 EFE37533.1 - 0.13 12.3 9.2 0.21 11.6 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) TraP PF07296.6 EFE37533.1 - 0.13 11.2 0.6 0.21 10.5 0.4 1.3 1 0 0 1 1 1 0 TraP protein Nucleoplasmin PF03066.10 EFE37533.1 - 0.15 11.5 7.2 0.22 11.0 5.0 1.2 1 0 0 1 1 1 0 Nucleoplasmin Daxx PF03344.10 EFE37533.1 - 0.26 9.7 9.0 0.31 9.4 6.2 1.1 1 0 0 1 1 1 0 Daxx Family Sigma70_ner PF04546.8 EFE37533.1 - 0.4 10.2 6.8 0.64 9.5 4.7 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region RXT2_N PF08595.6 EFE37533.1 - 0.43 10.3 5.5 0.76 9.5 3.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal LZ_Tnp_IS66 PF13007.2 EFE37533.1 - 0.56 10.8 8.4 0.078 13.6 2.9 1.8 2 0 0 2 2 1 0 Transposase C of IS166 homeodomain Myc_N PF01056.13 EFE37533.1 - 1.7 7.7 7.1 2.5 7.1 4.9 1.2 1 0 0 1 1 1 0 Myc amino-terminal region NOA36 PF06524.7 EFE37533.1 - 4.9 6.3 9.6 6.9 5.8 6.6 1.1 1 0 0 1 1 1 0 NOA36 protein Glyco_transf_15 PF01793.11 EFE37534.1 - 4.8e-118 393.8 16.7 5.4e-118 393.7 11.6 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Spc97_Spc98 PF04130.8 EFE37535.1 - 1.8e-61 208.1 6.9 2.6e-61 207.6 4.8 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family GCP5-Mod21 PF14609.1 EFE37535.1 - 6.5e-06 24.5 0.7 2.1e-05 22.9 0.1 2.0 2 1 0 2 2 2 1 gamma-Tubulin ring complex non-core subunit mod21 DUF1079 PF06435.6 EFE37535.1 - 0.18 11.7 1.0 5 7.1 0.1 2.6 2 0 0 2 2 2 0 Repeat of unknown function (DUF1079) GATase_5 PF13507.1 EFE37536.1 - 9.2e-94 313.1 0.0 1.6e-93 312.3 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 EFE37536.1 - 2.8e-44 150.8 0.4 1.5e-21 77.0 0.0 2.7 3 0 0 3 3 3 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 EFE37536.1 - 8.7e-27 93.2 0.1 1.6e-25 89.1 0.0 2.7 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Glycos_transf_1 PF00534.15 EFE37537.1 - 2.7e-16 59.4 0.0 1.5e-15 57.0 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFE37537.1 - 1.5e-06 28.3 0.1 2.8e-05 24.2 0.0 2.9 3 1 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EFE37537.1 - 0.00012 21.8 0.0 0.00028 20.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 60KD_IMP PF02096.15 EFE37538.1 - 7.3e-24 84.5 2.5 1.1e-23 83.9 1.7 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein PP2C PF00481.16 EFE37539.1 - 8e-41 140.1 0.0 1.3e-40 139.4 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 EFE37539.1 - 0.00013 21.4 0.0 0.00031 20.2 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 EFE37539.1 - 0.013 15.2 0.0 0.4 10.3 0.0 2.6 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) Tcf25 PF04910.9 EFE37540.1 - 2.2e-62 211.1 2.9 1.2e-55 188.9 0.2 2.3 1 1 1 2 2 2 2 Transcriptional repressor TCF25 RNase_H2-Ydr279 PF09468.5 EFE37540.1 - 7.4 5.6 8.3 14 4.7 5.4 1.6 2 0 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) PQ-loop PF04193.9 EFE37541.1 - 1.4e-18 66.1 2.4 1.4e-18 66.1 1.7 2.5 3 0 0 3 3 3 1 PQ loop repeat DUF3796 PF12676.2 EFE37541.1 - 0.018 15.2 0.3 0.029 14.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3796) DUF3278 PF11683.3 EFE37541.1 - 0.12 12.4 0.2 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) BCD PF15461.1 EFE37541.1 - 1.7 8.0 7.7 0.45 9.8 1.4 2.2 2 1 1 3 3 3 0 Beta-carotene 15,15'-dioxygenase Ribosomal_60s PF00428.14 EFE37542.1 - 6.8e-20 71.2 11.4 6.8e-16 58.4 6.7 2.1 2 0 0 2 2 2 2 60s Acidic ribosomal protein DUF2190 PF09956.4 EFE37542.1 - 0.047 13.4 0.5 0.15 11.7 0.0 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2190) DUF2408 PF10303.4 EFE37543.1 - 2.6e-55 186.1 0.1 3.6e-31 108.0 0.0 5.0 2 2 2 4 4 4 4 Protein of unknown function (DUF2408) DUF3941 PF13081.1 EFE37543.1 - 0.085 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3941) Aconitase PF00330.15 EFE37544.1 - 1.8e-154 514.6 0.0 8.7e-154 512.4 0.0 1.8 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFE37544.1 - 7.2e-40 136.1 0.0 1.2e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain HEAT PF02985.17 EFE37545.1 - 5.4e-21 72.7 9.0 0.005 16.8 0.0 11.3 12 0 0 12 12 12 5 HEAT repeat HEAT_2 PF13646.1 EFE37545.1 - 6.2e-21 74.4 9.5 5.2e-06 26.6 0.1 8.5 6 2 4 10 10 10 6 HEAT repeats HEAT_EZ PF13513.1 EFE37545.1 - 6e-17 61.5 13.8 8.1e-05 22.9 0.1 9.7 8 2 2 10 10 9 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFE37545.1 - 2.2e-09 37.5 0.0 0.092 13.1 0.0 5.8 3 2 2 5 5 5 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.3 EFE37545.1 - 7e-07 28.3 0.1 0.015 14.0 0.0 4.7 5 1 1 6 6 6 2 RNAPII transcription regulator C-terminal RIX1 PF08167.7 EFE37545.1 - 3e-06 26.9 0.0 0.011 15.4 0.0 4.7 4 1 1 5 5 5 1 rRNA processing/ribosome biogenesis CLASP_N PF12348.3 EFE37545.1 - 5.7e-05 22.5 0.1 0.15 11.4 0.0 4.9 4 1 1 5 5 5 1 CLASP N terminal Arm PF00514.18 EFE37545.1 - 6.5e-05 22.6 2.4 2.9 7.8 0.0 5.8 6 0 0 6 6 5 2 Armadillo/beta-catenin-like repeat DUF3385 PF11865.3 EFE37545.1 - 0.00028 20.8 0.5 8.2 6.3 0.0 4.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3385) Proteasom_PSMB PF10508.4 EFE37545.1 - 0.00029 19.2 0.3 0.0012 17.2 0.0 2.2 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.15 EFE37545.1 - 0.00053 18.4 0.9 0.011 14.1 0.1 3.3 3 1 1 4 4 4 1 Adaptin N terminal region Cnd1 PF12717.2 EFE37545.1 - 0.0034 17.2 0.2 0.37 10.6 0.0 3.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 DUF4042 PF13251.1 EFE37545.1 - 0.0055 16.1 2.6 17 4.8 0.0 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4042) V-ATPase_H_N PF03224.9 EFE37545.1 - 0.011 14.8 0.9 0.21 10.6 0.0 3.1 3 0 0 3 3 3 0 V-ATPase subunit H Phosphodiest PF01663.17 EFE37547.1 - 4.9e-13 49.1 0.0 7.8e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 EFE37547.1 - 0.004 16.5 0.1 0.0085 15.4 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 EFE37547.1 - 0.059 12.5 0.0 0.093 11.9 0.0 1.3 1 0 0 1 1 1 0 Sulfatase RRM_2 PF04059.7 EFE37551.1 - 1.2e-08 34.8 0.2 2.7e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.17 EFE37551.1 - 1.1e-05 24.9 0.1 0.016 14.7 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE37551.1 - 0.0066 16.2 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Daxx PF03344.10 EFE37552.1 - 3.1 6.1 27.3 6 5.2 0.0 2.0 2 0 0 2 2 2 0 Daxx Family Sod_Cu PF00080.15 EFE37554.1 - 1.6e-44 151.4 6.6 2.1e-44 151.1 4.5 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Transaldolase PF00923.14 EFE37555.1 - 3.2e-94 315.2 0.1 3.7e-94 315.0 0.1 1.0 1 0 0 1 1 1 1 Transaldolase Beach PF02138.13 EFE37556.1 - 1.7e-107 358.8 0.0 3.6e-107 357.8 0.0 1.6 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 EFE37556.1 - 2.9e-11 43.1 2.4 3.7e-11 42.7 0.0 2.3 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 EFE37556.1 - 1.1e-06 28.9 0.0 2.6e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF2634 PF10934.3 EFE37556.1 - 0.061 13.0 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2634) Peptidase_S8 PF00082.17 EFE37558.1 - 4.5e-53 180.2 8.3 6.9e-53 179.6 5.8 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE37558.1 - 1.4e-20 73.6 0.2 3.2e-20 72.4 0.2 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 EXS PF03124.9 EFE37559.1 - 5.6e-74 249.2 13.9 6.5e-74 249.0 9.7 1.0 1 0 0 1 1 1 1 EXS family SPX PF03105.14 EFE37560.1 - 3.8e-41 141.6 0.3 5.7e-41 141.1 0.2 1.2 1 0 0 1 1 1 1 SPX domain Ndc1_Nup PF09531.5 EFE37560.1 - 1.3 7.4 5.8 0.46 8.8 0.2 2.4 2 1 1 3 3 3 0 Nucleoporin protein Ndc1-Nup HAD_2 PF13419.1 EFE37561.1 - 6.9e-10 39.4 0.0 1.3e-09 38.5 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE37561.1 - 4e-07 29.6 0.0 7.4e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EFE37561.1 - 2.3e-06 28.1 0.0 3e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1830 PF08865.6 EFE37561.1 - 0.081 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Abhydrolase_5 PF12695.2 EFE37562.1 - 1.1e-10 41.4 0.0 4.3e-10 39.5 0.0 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE37562.1 - 2.5e-08 34.0 0.0 4.4e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1100 PF06500.6 EFE37562.1 - 3.1e-05 22.7 0.0 7.5e-05 21.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) BAAT_C PF08840.6 EFE37562.1 - 0.00047 19.9 0.0 0.00082 19.1 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.13 EFE37562.1 - 0.00058 19.2 0.0 0.11 11.7 0.0 2.4 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.16 EFE37562.1 - 0.0017 17.6 0.0 0.0041 16.3 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Zn_clus PF00172.13 EFE37563.1 - 5.1e-05 23.0 4.5 9.3e-05 22.2 3.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EFE37563.1 - 0.0094 14.5 0.7 0.012 14.2 0.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Multi_ubiq PF14452.1 EFE37563.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 Multiubiquitin Abhydrolase_2 PF02230.11 EFE37564.1 - 1.2e-20 73.8 0.0 1.5e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EFE37564.1 - 1e-08 35.3 0.2 1.2e-08 35.0 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE37564.1 - 1.3e-05 25.0 0.1 1.9e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0118 PF01594.11 EFE37565.1 - 0.2 10.5 0.0 0.35 9.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF20 Metallophos PF00149.23 EFE37566.1 - 1.1e-40 139.1 1.2 1.9e-40 138.4 0.9 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ORF6C PF10552.4 EFE37569.1 - 0.17 11.6 1.3 0.2 11.4 0.1 1.8 2 0 0 2 2 2 0 ORF6C domain CENP-Q PF13094.1 EFE37569.1 - 0.27 11.2 5.3 0.83 9.6 0.3 2.5 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit CCDC-167 PF15188.1 EFE37569.1 - 5.4 7.0 7.4 32 4.5 1.8 3.2 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 Voldacs PF03517.8 EFE37570.1 - 2.6e-14 53.2 2.1 2.6e-14 53.2 1.5 1.8 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling LIP PF03583.9 EFE37571.1 - 3.8e-74 249.5 0.0 5.2e-74 249.0 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_5 PF12695.2 EFE37571.1 - 0.00024 20.8 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family HTH_30 PF13556.1 EFE37572.1 - 0.37 10.4 2.8 0.98 9.0 2.0 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DUF3595 PF12166.3 EFE37573.1 - 0.0014 17.5 1.8 0.0018 17.2 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3595) Cytokin_check_N PF10407.4 EFE37574.1 - 0.0057 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Thioesterase PF00975.15 EFE37575.1 - 4.1e-22 79.5 0.0 9.8e-22 78.2 0.0 1.6 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 EFE37575.1 - 3.4e-10 40.1 0.0 4.5e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE37575.1 - 5.4e-05 22.9 0.0 7.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE37575.1 - 0.0092 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 EFE37575.1 - 0.016 14.6 0.1 0.031 13.7 0.0 1.5 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.8 EFE37575.1 - 0.08 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold p450 PF00067.17 EFE37576.1 - 3.2e-56 190.8 0.0 4e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Bacillus_PapR PF05968.6 EFE37577.1 - 0.024 14.6 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 Bacillus PapR protein MFS_1 PF07690.11 EFE37578.1 - 9e-13 47.6 19.9 1.4e-10 40.4 7.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37578.1 - 4.6e-06 25.4 10.0 8.3e-06 24.6 6.8 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter O-antigen_lig PF13425.1 EFE37578.1 - 0.0087 16.0 2.9 0.02 14.8 2.0 1.6 1 0 0 1 1 1 1 O-antigen ligase like membrane protein AA_permease PF00324.16 EFE37579.1 - 2.1e-134 448.4 46.3 2.4e-134 448.2 32.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE37579.1 - 1.3e-36 126.1 50.1 1.6e-36 125.8 34.7 1.1 1 0 0 1 1 1 1 Amino acid permease Abhydrolase_5 PF12695.2 EFE37580.1 - 2.5e-12 46.7 0.0 3.9e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE37580.1 - 1.2e-10 41.7 2.2 2.8e-10 40.4 1.5 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFE37580.1 - 2.3e-05 24.0 0.0 3.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 EFE37580.1 - 3.9e-05 23.3 0.0 0.16 11.4 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold LIP PF03583.9 EFE37580.1 - 5.4e-05 22.5 0.0 0.21 10.7 0.0 2.1 2 0 0 2 2 2 2 Secretory lipase Peptidase_S15 PF02129.13 EFE37580.1 - 0.0018 17.7 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.16 EFE37580.1 - 0.0036 16.5 0.0 0.0073 15.5 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF2235 PF09994.4 EFE37580.1 - 0.052 12.9 0.0 0.067 12.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) OpgC_C PF10129.4 EFE37581.1 - 0.086 11.4 0.2 0.12 11.0 0.1 1.1 1 0 0 1 1 1 0 OpgC protein Methyltransf_23 PF13489.1 EFE37582.1 - 2.3e-19 69.6 0.1 5.5e-19 68.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE37582.1 - 4.7e-06 26.2 0.0 0.0028 17.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFE37582.1 - 7.2e-06 26.5 0.1 9.1e-05 23.0 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE37582.1 - 2.1e-05 24.9 0.0 5.6e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE37582.1 - 0.0028 17.9 0.1 0.016 15.5 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE37582.1 - 0.019 15.4 0.0 0.047 14.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EFE37582.1 - 0.084 12.4 0.0 0.46 9.9 0.0 2.0 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UQ_con PF00179.21 EFE37583.1 - 0.00023 20.6 0.0 0.00037 19.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme AAA_11 PF13086.1 EFE37584.1 - 1.6e-61 207.8 0.3 1.6e-61 207.8 0.2 2.4 3 0 0 3 3 2 1 AAA domain AAA_12 PF13087.1 EFE37584.1 - 3.1e-47 160.5 0.0 1.1e-46 158.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain HhH-GPD PF00730.20 EFE37584.1 - 1.6e-19 70.2 0.1 1.4e-18 67.1 0.0 2.6 3 0 0 3 3 2 1 HhH-GPD superfamily base excision DNA repair protein AAA_19 PF13245.1 EFE37584.1 - 1.7e-14 53.3 2.1 6.4e-13 48.2 0.0 3.4 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 EFE37584.1 - 2e-12 47.0 0.0 2e-10 40.6 0.0 3.2 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 EFE37584.1 - 7.3e-08 32.4 0.1 2.4e-07 30.7 0.0 1.9 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 EFE37584.1 - 4.7e-07 29.0 0.2 5.6e-06 25.5 0.1 2.3 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) HHH PF00633.18 EFE37584.1 - 6.4e-06 25.5 0.0 1.8e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif Viral_helicase1 PF01443.13 EFE37584.1 - 1e-05 25.2 0.1 0.24 10.8 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 EFE37584.1 - 1.5e-05 25.1 0.1 0.00029 20.9 0.1 2.8 1 1 0 1 1 1 1 AAA domain PIF1 PF05970.9 EFE37584.1 - 1.7e-05 23.9 0.0 0.18 10.6 0.0 2.7 3 0 0 3 3 3 2 PIF1-like helicase Helicase_RecD PF05127.9 EFE37584.1 - 0.00013 21.6 0.0 0.0079 15.8 0.0 3.2 2 1 0 2 2 2 1 Helicase AAA_16 PF13191.1 EFE37584.1 - 0.00015 21.8 1.7 0.00045 20.2 0.0 2.6 3 0 0 3 3 2 1 AAA ATPase domain T2SE PF00437.15 EFE37584.1 - 0.00022 20.2 0.0 0.00058 18.8 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.9 EFE37584.1 - 0.0011 18.7 0.1 0.0029 17.3 0.0 1.7 1 0 0 1 1 1 1 Flavivirus DEAD domain TrwB_AAD_bind PF10412.4 EFE37584.1 - 0.0011 17.6 0.0 0.0026 16.4 0.0 1.5 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain UvrD-helicase PF00580.16 EFE37584.1 - 0.0013 18.0 0.2 0.0013 18.0 0.2 2.5 3 1 0 3 3 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 EFE37584.1 - 0.0014 18.2 0.1 0.0086 15.5 0.0 2.2 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain PhoH PF02562.11 EFE37584.1 - 0.0014 17.9 0.0 0.15 11.3 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein IstB_IS21 PF01695.12 EFE37584.1 - 0.0059 16.0 0.0 0.014 14.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.9 EFE37584.1 - 0.0061 16.2 0.0 0.031 14.0 0.0 2.3 3 0 0 3 3 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 EFE37584.1 - 0.014 15.5 0.0 0.096 12.8 0.0 2.5 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.18 EFE37584.1 - 0.022 14.1 0.2 0.076 12.4 0.1 2.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Herpes_ori_bp PF02399.10 EFE37584.1 - 0.032 12.2 0.0 0.06 11.3 0.0 1.3 1 0 0 1 1 1 0 Origin of replication binding protein 4HB_MCP_1 PF12729.2 EFE37584.1 - 0.044 13.1 0.1 0.044 13.1 0.0 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction OKR_DC_1_N PF03709.10 EFE37584.1 - 0.088 12.8 0.1 7 6.7 0.0 3.4 3 0 0 3 3 3 0 Orn/Lys/Arg decarboxylase, N-terminal domain TK PF00265.13 EFE37584.1 - 0.13 11.8 0.0 0.87 9.1 0.0 2.3 2 0 0 2 2 2 0 Thymidine kinase Pkinase PF00069.20 EFE37585.1 - 1.3e-34 119.5 0.0 1.5e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37585.1 - 3.3e-22 78.7 0.0 1.4e-21 76.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EFE37585.1 - 8.3e-05 22.4 0.1 0.007 16.1 0.0 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 EFE37585.1 - 0.12 11.3 0.1 0.97 8.3 0.0 2.2 1 1 1 2 2 2 0 Kinase-like APH PF01636.18 EFE37586.1 - 7.6e-13 48.7 0.0 9.6e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE37586.1 - 5e-05 22.9 0.0 0.00018 21.1 0.0 1.9 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 EFE37586.1 - 0.013 14.9 0.0 0.026 13.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family C2 PF00168.25 EFE37587.1 - 1.1e-63 211.0 2.4 2.4e-17 62.5 0.0 5.7 5 0 0 5 5 5 5 C2 domain TPR_11 PF13414.1 EFE37588.1 - 2.8e-51 171.0 27.7 7.3e-16 57.5 1.0 6.4 5 1 0 6 6 6 6 TPR repeat TPR_1 PF00515.23 EFE37588.1 - 5.5e-38 127.0 27.6 1.7e-05 24.1 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.12 EFE37588.1 - 3.3e-30 101.5 26.6 0.00019 21.0 0.1 9.8 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 EFE37588.1 - 5.4e-16 58.3 16.4 8.1e-08 32.0 0.3 5.6 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFE37588.1 - 2.3e-15 56.8 17.2 0.0011 19.5 0.2 6.8 3 3 4 7 7 7 7 Tetratricopeptide repeat TPR_19 PF14559.1 EFE37588.1 - 6.5e-14 52.0 23.5 0.00021 21.5 0.4 6.3 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE37588.1 - 8.3e-14 50.8 19.1 0.31 11.8 0.2 9.9 6 3 4 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.1 EFE37588.1 - 5.6e-11 41.4 16.8 0.051 13.3 0.2 8.2 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.1 EFE37588.1 - 1.2e-10 40.7 11.7 0.003 17.6 0.1 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFE37588.1 - 1.6e-07 31.0 9.4 0.0071 16.1 0.3 5.4 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE37588.1 - 2.3e-06 26.9 14.9 0.033 13.9 0.0 7.3 8 0 0 8 8 8 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE37588.1 - 0.00019 21.5 14.8 0.032 14.3 0.8 3.8 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Inhibitor_I9 PF05922.11 EFE37588.1 - 0.0025 18.3 0.2 0.013 16.0 0.0 2.3 2 0 0 2 2 1 1 Peptidase inhibitor I9 TPR_6 PF13174.1 EFE37588.1 - 0.1 13.0 23.1 3.4 8.3 0.0 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 EFE37588.1 - 6.3 6.1 11.0 12 5.2 0.1 5.6 7 0 0 7 7 7 0 SHNi-TPR RNA_pol_Rpc34 PF05158.7 EFE37589.1 - 6.6e-102 341.0 0.0 7.3e-102 340.8 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit Rrf2 PF02082.15 EFE37589.1 - 0.11 12.5 0.1 0.93 9.6 0.0 2.2 2 0 0 2 2 2 0 Transcriptional regulator PadR PF03551.9 EFE37589.1 - 0.15 11.8 0.0 0.69 9.7 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family ING PF12998.2 EFE37590.1 - 5.8e-24 84.3 3.6 9.4e-24 83.7 2.5 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 EFE37590.1 - 1.9e-08 33.8 9.9 3.4e-08 33.0 6.9 1.5 1 0 0 1 1 1 1 PHD-finger CCDC144C PF14915.1 EFE37590.1 - 0.048 12.5 1.2 0.09 11.6 0.8 1.4 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DUF4200 PF13863.1 EFE37590.1 - 0.3 11.0 1.9 2.5 8.0 1.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) TFIIA PF03153.8 EFE37590.1 - 4.1 7.1 17.3 3.2 7.5 11.0 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hist_deacetyl PF00850.14 EFE37591.1 - 4.2e-76 256.1 0.2 6e-76 255.7 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain BSP_II PF05432.6 EFE37591.1 - 0.7 9.1 6.3 1 8.5 4.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Isochorismatase PF00857.15 EFE37592.1 - 8.7e-25 87.6 0.1 8e-21 74.7 0.0 2.1 2 0 0 2 2 2 2 Isochorismatase family AAA_11 PF13086.1 EFE37592.1 - 0.13 11.8 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain F-box-like PF12937.2 EFE37593.1 - 0.00019 21.0 0.5 0.0005 19.7 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE37593.1 - 0.0025 17.3 0.8 0.006 16.2 0.6 1.6 1 0 0 1 1 1 1 F-box domain DNA_Packaging PF11053.3 EFE37593.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Terminase DNA packaging enzyme ICE2 PF08426.5 EFE37595.1 - 5.1e-137 456.8 17.4 5.9e-137 456.6 12.0 1.0 1 0 0 1 1 1 1 ICE2 ABC_membrane_2 PF06472.10 EFE37595.1 - 0.46 9.5 4.3 0.42 9.6 0.2 2.3 2 0 0 2 2 2 0 ABC transporter transmembrane region 2 Endosulfine PF04667.12 EFE37596.1 - 2e-21 75.7 0.1 4.5e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region RNA_Me_trans PF04252.8 EFE37597.1 - 5e-14 52.1 0.0 5.6e-14 51.9 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Peptidase_S10 PF00450.17 EFE37598.1 - 8e-91 305.2 0.0 1e-90 304.9 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 EFE37598.1 - 0.065 13.0 0.0 0.33 10.7 0.0 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF2207 PF09972.4 EFE37598.1 - 0.068 11.7 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SnoaL PF07366.7 EFE37599.1 - 0.022 14.3 0.1 0.037 13.6 0.1 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase Mito_carr PF00153.22 EFE37600.1 - 3.3e-47 158.1 8.6 3.4e-20 71.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CBS PF00571.23 EFE37601.1 - 0.00033 20.3 0.0 1.3 8.8 0.0 3.2 2 1 1 3 3 3 2 CBS domain MFS_1 PF07690.11 EFE37602.1 - 9.2e-43 146.2 53.5 7.3e-42 143.3 37.2 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE37602.1 - 3.1e-17 62.0 17.6 3.1e-17 62.0 12.2 1.6 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE37602.1 - 5.1e-12 45.0 13.4 5.1e-12 45.0 9.3 3.5 3 2 1 4 4 4 2 Sugar (and other) transporter PPR_3 PF13812.1 EFE37603.1 - 0.16 12.3 2.5 57 4.3 0.0 5.1 5 0 0 5 5 5 0 Pentatricopeptide repeat domain ECH PF00378.15 EFE37604.1 - 3.6e-50 170.3 0.0 4.4e-50 170.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Pox_P21 PF05313.7 EFE37604.1 - 0.17 11.0 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P21 membrane protein AAA_16 PF13191.1 EFE37605.1 - 7.7e-07 29.2 0.8 4.1e-05 23.6 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.17 EFE37605.1 - 8.5e-07 28.1 0.0 1.3e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Abhydrolase_6 PF12697.2 EFE37605.1 - 4.6e-06 26.6 3.7 6.5e-05 22.9 0.0 3.1 3 0 0 3 3 3 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFE37605.1 - 0.00011 21.8 0.1 0.00058 19.5 0.0 2.1 1 1 1 2 2 2 1 PGAP1-like protein DUF676 PF05057.9 EFE37605.1 - 0.00012 21.5 0.4 0.00052 19.3 0.2 1.9 1 1 0 1 1 1 1 Putative serine esterase (DUF676) AAA_22 PF13401.1 EFE37605.1 - 0.00028 21.0 0.0 0.00096 19.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 EFE37605.1 - 0.0051 16.4 0.0 0.061 12.9 0.0 2.4 1 1 0 1 1 1 1 NACHT domain AAA_17 PF13207.1 EFE37605.1 - 0.014 16.2 0.0 0.032 15.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFE37605.1 - 0.019 14.8 0.0 0.019 14.8 0.0 2.3 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.7 EFE37605.1 - 0.019 14.0 1.9 0.026 13.6 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin KaiC PF06745.8 EFE37605.1 - 0.059 12.4 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 KaiC Sigma54_activat PF00158.21 EFE37605.1 - 0.06 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_10 PF12846.2 EFE37605.1 - 0.1 11.9 0.0 0.28 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain Arch_ATPase PF01637.13 EFE37605.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase YcxB PF14317.1 EFE37605.1 - 0.19 11.0 0.1 0.57 9.4 0.1 1.8 1 0 0 1 1 1 0 YcxB-like protein HMG_box PF00505.14 EFE37606.1 - 3.8e-24 84.7 0.5 3.8e-24 84.7 0.4 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFE37606.1 - 4.6e-19 68.5 0.9 7.6e-19 67.8 0.6 1.4 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 EFE37606.1 - 0.0031 17.2 0.3 0.0031 17.2 0.2 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box 5 DUF1014 PF06244.7 EFE37606.1 - 0.005 17.0 0.8 0.02 15.1 0.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) DUF2628 PF10947.3 EFE37608.1 - 0.23 11.2 0.7 0.37 10.5 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Bac_export_3 PF01313.14 EFE37608.1 - 0.29 10.8 3.3 0.42 10.3 2.3 1.1 1 0 0 1 1 1 0 Bacterial export proteins, family 3 ThiF PF00899.16 EFE37609.1 - 5.5e-40 136.3 0.0 9.4e-40 135.5 0.0 1.4 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 EFE37609.1 - 2.2e-25 88.0 0.1 4.1e-25 87.1 0.0 1.5 1 0 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 EFE37609.1 - 5.2e-12 46.1 0.0 1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.15 EFE37609.1 - 0.021 14.9 0.0 0.059 13.4 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 EFE37609.1 - 0.037 12.9 0.2 0.037 12.9 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase YlqD PF11068.3 EFE37609.1 - 0.064 13.2 2.8 0.099 12.6 2.0 1.3 1 0 0 1 1 1 0 YlqD protein FAD_binding_3 PF01494.14 EFE37609.1 - 0.084 11.9 0.8 0.13 11.3 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain FlxA PF14282.1 EFE37609.1 - 0.092 12.6 4.9 0.17 11.8 3.4 1.4 1 0 0 1 1 1 0 FlxA-like protein HR1 PF02185.11 EFE37609.1 - 0.11 12.2 3.6 0.24 11.1 2.5 1.6 1 0 0 1 1 1 0 Hr1 repeat DUF4463 PF14703.1 EFE37609.1 - 0.13 12.7 0.5 0.37 11.3 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4463) ApbA PF02558.11 EFE37609.1 - 0.14 11.6 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DivIC PF04977.10 EFE37609.1 - 0.26 10.8 2.4 0.45 10.0 1.6 1.3 1 0 0 1 1 1 0 Septum formation initiator FbpA PF05833.6 EFE37609.1 - 0.71 8.3 2.7 0.96 7.9 1.8 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) SLX9 PF15341.1 EFE37610.1 - 1e-37 129.2 0.2 3.2e-37 127.6 0.0 1.7 1 1 1 2 2 2 1 Ribosome biogenesis protein SLX9 NAD_Gly3P_dh_C PF07479.9 EFE37611.1 - 3.7e-42 143.5 0.1 6.8e-42 142.7 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.18 EFE37611.1 - 2e-36 125.0 0.0 3.3e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pox_VLTF3 PF04947.9 EFE37611.1 - 0.02 14.4 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 Poxvirus Late Transcription Factor VLTF3 like hDGE_amylase PF14701.1 EFE37612.1 - 2e-169 563.9 0.0 2.6e-169 563.5 0.0 1.1 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme GDE_C PF06202.9 EFE37612.1 - 2.1e-117 391.9 0.3 3.8e-117 391.1 0.0 1.5 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.1 EFE37612.1 - 3.9e-86 288.4 0.0 7.8e-86 287.4 0.0 1.5 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 EFE37612.1 - 1.7e-27 95.0 0.0 3.4e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.19 EFE37612.1 - 1.2e-05 24.8 0.1 0.0084 15.5 0.0 2.6 3 0 0 3 3 3 2 Alpha amylase, catalytic domain DUF221 PF02714.10 EFE37613.1 - 3.9e-79 265.8 25.0 2.3e-78 263.2 17.3 2.2 1 1 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFE37613.1 - 1.9e-39 134.7 0.9 1.9e-39 134.7 0.6 2.6 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 EFE37613.1 - 3.1e-24 85.2 0.4 5.5e-24 84.5 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) MFS_1 PF07690.11 EFE37614.1 - 8.3e-16 57.6 31.1 8.3e-16 57.6 21.5 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF486 PF04342.7 EFE37614.1 - 0.49 10.4 6.2 1.9 8.6 0.2 3.8 4 0 0 4 4 4 0 Protein of unknown function, DUF486 DAHP_synth_1 PF00793.15 EFE37615.1 - 1e-99 332.6 0.1 1.2e-99 332.3 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family AIG2_2 PF13772.1 EFE37617.1 - 2.4e-06 27.5 0.0 2.5e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 AIG2-like family Hormone_3 PF00159.13 EFE37617.1 - 1.6 8.8 5.0 2.3 8.3 0.4 2.5 2 0 0 2 2 2 0 Pancreatic hormone peptide Cytochrom_C1 PF02167.10 EFE37618.1 - 1.7e-80 269.7 0.0 2.4e-80 269.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C1 family SbcCD_C PF13558.1 EFE37618.1 - 0.00087 19.1 0.5 0.0017 18.2 0.3 1.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Cytochrome_CBB3 PF13442.1 EFE37618.1 - 0.092 12.9 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III AAA PF00004.24 EFE37619.1 - 1e-27 96.9 0.0 2.3e-27 95.7 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE37619.1 - 5.1e-06 27.3 0.0 1e-05 26.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFE37619.1 - 7.5e-06 26.1 0.0 1.8e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE37619.1 - 9.2e-06 25.7 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.1 EFE37619.1 - 3.4e-05 23.5 0.0 8.1e-05 22.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.1 EFE37619.1 - 3.5e-05 24.1 0.0 5.8e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EFE37619.1 - 5.6e-05 22.6 0.0 0.00098 18.5 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EFE37619.1 - 0.00018 21.3 0.0 0.00034 20.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EFE37619.1 - 0.00034 20.7 0.1 0.0011 19.1 0.0 1.9 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.9 EFE37619.1 - 0.00048 19.8 0.1 0.0015 18.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.7 EFE37619.1 - 0.0006 19.5 0.0 0.0012 18.5 0.0 1.4 1 1 0 1 1 1 1 NACHT domain AAA_33 PF13671.1 EFE37619.1 - 0.00097 19.0 0.0 0.0017 18.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EFE37619.1 - 0.0011 18.7 0.1 0.0072 16.0 0.0 2.1 1 1 0 1 1 1 1 Archaeal ATPase UPF0079 PF02367.12 EFE37619.1 - 0.0017 18.0 0.0 0.0035 16.9 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_19 PF13245.1 EFE37619.1 - 0.0021 17.7 0.0 0.0043 16.7 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 EFE37619.1 - 0.0025 16.8 0.1 0.013 14.5 0.0 1.9 1 1 1 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 EFE37619.1 - 0.0055 16.1 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.1 EFE37619.1 - 0.0057 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 EFE37619.1 - 0.0085 15.0 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.5 EFE37619.1 - 0.012 14.8 0.1 0.052 12.7 0.0 1.9 1 1 0 2 2 2 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 EFE37619.1 - 0.017 14.2 0.0 0.033 13.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin DUF815 PF05673.8 EFE37619.1 - 0.019 13.9 0.0 0.041 12.8 0.0 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 EFE37619.1 - 0.022 13.9 0.0 0.11 11.6 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 EFE37619.1 - 0.023 14.6 0.0 0.049 13.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) MobB PF03205.9 EFE37619.1 - 0.034 13.8 0.0 0.074 12.7 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_11 PF13086.1 EFE37619.1 - 0.042 13.4 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 EFE37619.1 - 0.053 13.1 0.0 0.096 12.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 EFE37619.1 - 0.057 12.1 0.0 0.089 11.4 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus KAP_NTPase PF07693.9 EFE37619.1 - 0.082 11.8 0.0 0.14 11.0 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain AAA_13 PF13166.1 EFE37619.1 - 0.13 10.6 0.0 0.18 10.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EFE37619.1 - 0.16 12.3 0.0 0.3 11.3 0.0 1.5 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.4 EFE37619.1 - 0.16 11.4 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sec10 PF07393.6 EFE37620.1 - 2.9e-148 495.1 0.0 3.7e-148 494.8 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box PF00646.28 EFE37620.1 - 0.00016 21.2 0.7 0.00036 20.0 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EFE37620.1 - 0.00047 19.8 0.0 0.001 18.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like RINT1_TIP1 PF04437.8 EFE37620.1 - 0.036 12.6 0.3 0.073 11.6 0.0 1.6 2 0 0 2 2 2 0 RINT-1 / TIP-1 family WD40 PF00400.27 EFE37621.1 - 2.2e-77 252.4 23.9 1.4e-15 56.4 0.4 8.5 8 0 0 8 8 8 8 WD domain, G-beta repeat Nup160 PF11715.3 EFE37621.1 - 2.5e-07 29.2 10.2 0.088 10.9 0.1 5.6 3 3 2 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.6 EFE37621.1 - 1.2e-06 28.3 0.2 0.32 10.6 0.0 3.9 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A NLE PF08154.7 EFE37621.1 - 3.2e-05 23.8 0.0 6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain MutS_II PF05188.12 EFE37622.1 - 3.7e-10 40.0 0.1 4.4e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 MutS domain II MutS_V PF00488.16 EFE37623.1 - 1.4e-74 250.4 0.6 2.1e-74 249.9 0.4 1.2 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFE37623.1 - 2.5e-26 92.7 0.1 6.2e-25 88.1 0.0 2.8 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.13 EFE37623.1 - 1.6e-09 37.8 1.2 2.8e-06 27.3 0.3 3.7 2 1 0 2 2 2 2 MutS family domain IV AAA_30 PF13604.1 EFE37623.1 - 0.02 14.4 0.1 0.046 13.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain Tudor-knot PF11717.3 EFE37624.1 - 0.047 13.4 0.4 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain DUF221 PF02714.10 EFE37625.1 - 8.6e-104 346.8 28.5 1.9e-103 345.7 17.1 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFE37625.1 - 1.4e-41 141.6 2.0 1.4e-41 141.6 1.4 2.7 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EFE37625.1 - 3.1e-29 100.7 0.4 1.7e-28 98.3 0.1 2.2 2 0 0 2 2 2 1 Phosphate metabolism protein DUF4463 PF14703.1 EFE37625.1 - 1.9e-14 53.9 0.5 3.6e-14 53.0 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) Rubella_E2 PF05749.6 EFE37625.1 - 0.053 12.7 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 NEP PF10167.4 EFE37627.1 - 0.026 14.2 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein E3_UbLigase_EDD PF11547.3 EFE37627.1 - 0.064 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD Abhydrolase_1 PF00561.15 EFE37628.1 - 1e-19 71.0 0.0 1.2e-19 70.7 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFE37628.1 - 5.1e-15 55.9 0.1 7.3e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE37628.1 - 2.1e-05 24.3 0.0 3.9e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EFE37628.1 - 0.00045 20.0 0.0 0.00097 18.9 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Esterase PF00756.15 EFE37628.1 - 0.044 13.2 0.0 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 Putative esterase Ndr PF03096.9 EFE37628.1 - 0.14 10.6 0.0 0.2 10.0 0.0 1.1 1 0 0 1 1 1 0 Ndr family HemX PF04375.9 EFE37628.1 - 0.15 10.6 1.0 0.22 10.0 0.7 1.1 1 0 0 1 1 1 0 HemX Peptidase_S10 PF00450.17 EFE37629.1 - 0.1 11.7 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase Peptidase_S10 PF00450.17 EFE37630.1 - 1.9e-88 297.4 0.0 2.1e-88 297.2 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase NmrA PF05368.8 EFE37631.1 - 1.7e-07 30.7 0.0 0.014 14.6 0.0 2.1 1 1 0 2 2 2 2 NmrA-like family adh_short PF00106.20 EFE37631.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_10 PF13460.1 EFE37631.1 - 0.036 14.0 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding Saccharop_dh PF03435.13 EFE37631.1 - 0.065 12.2 0.0 0.096 11.6 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase DLH PF01738.13 EFE37632.1 - 1e-30 106.6 0.0 1.2e-30 106.4 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EFE37632.1 - 1.5e-07 31.2 0.0 1.9e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE37632.1 - 0.018 14.9 0.0 0.058 13.2 0.0 1.5 1 1 1 2 2 2 0 Alpha/beta hydrolase family eIF2A PF08662.6 EFE37633.1 - 1.9e-38 132.1 7.7 1.1e-36 126.4 1.1 4.2 3 3 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A RRM_5 PF13893.1 EFE37633.1 - 2.6e-07 30.3 0.0 6.3e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE37633.1 - 4.6e-07 29.3 0.0 1.3e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE37633.1 - 2.5e-06 27.3 0.0 8.8e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 EFE37633.1 - 0.0002 21.0 0.1 0.1 12.4 0.0 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat SWIB PF02201.13 EFE37634.1 - 8.2e-19 67.0 0.1 1.3e-18 66.4 0.1 1.3 1 0 0 1 1 1 1 SWIB/MDM2 domain RapA_C PF12137.3 EFE37634.1 - 0.018 13.9 0.7 0.021 13.7 0.5 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal MCLC PF05934.6 EFE37634.1 - 2.2 6.4 5.1 2.7 6.1 3.5 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Fungal_trans_2 PF11951.3 EFE37635.1 - 5.4e-54 183.2 0.0 8.2e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE37635.1 - 0.02 14.7 8.7 0.037 13.9 6.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Pam17 PF08566.5 EFE37636.1 - 1e-70 236.9 0.1 1.3e-70 236.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 DUF2076 PF09849.4 EFE37636.1 - 0.025 14.6 0.0 2.7 8.0 0.0 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Beta_elim_lyase PF01212.16 EFE37636.1 - 0.13 11.4 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase U79_P34 PF03064.11 EFE37638.1 - 0.11 12.0 5.5 0.12 11.8 3.8 1.0 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Cpn60_TCP1 PF00118.19 EFE37640.1 - 1.1e-112 377.1 9.0 1.3e-112 376.8 6.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pro_isomerase PF00160.16 EFE37641.1 - 1.3e-50 171.5 0.1 3.1e-50 170.3 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.27 EFE37641.1 - 4.9e-11 42.0 0.3 0.01 15.6 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat Ribonuc_2-5A PF06479.7 EFE37642.1 - 8.4e-42 142.0 0.0 1.9e-41 140.9 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.20 EFE37642.1 - 2e-39 135.3 0.0 3.5e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37642.1 - 6.8e-19 67.9 0.0 2.7e-18 66.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.16 EFE37642.1 - 0.00041 19.7 0.0 0.076 12.5 0.0 3.1 3 0 0 3 3 3 1 PQQ enzyme repeat Kdo PF06293.9 EFE37642.1 - 0.0011 18.0 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 EFE37642.1 - 0.0026 17.1 0.0 0.0047 16.2 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL PQQ_2 PF13360.1 EFE37642.1 - 0.013 14.9 0.0 0.3 10.5 0.0 2.2 1 1 0 2 2 2 0 PQQ-like domain HAD_2 PF13419.1 EFE37643.1 - 1.3e-13 51.5 0.0 1.8e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE37643.1 - 7.1e-05 22.4 0.0 0.0003 20.4 0.0 2.0 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 EFE37643.1 - 0.00016 22.2 0.0 0.00063 20.2 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cut8_N PF14482.1 EFE37644.1 - 0.17 11.9 7.6 2.2 8.3 1.1 2.9 2 1 0 2 2 2 0 Cut8 proteasome-binding domain WD40 PF00400.27 EFE37646.1 - 0.014 15.2 0.8 15 5.6 0.0 4.6 5 0 0 5 5 5 0 WD domain, G-beta repeat Nucleoporin_FG PF13634.1 EFE37647.1 - 3.8e-10 39.9 85.4 0.0017 18.5 35.1 3.1 1 1 1 2 2 2 2 Nucleoporin FG repeat region Lectin_N PF03954.9 EFE37647.1 - 0.0099 15.2 0.4 0.69 9.3 0.0 2.3 2 0 0 2 2 2 2 Hepatic lectin, N-terminal domain DUF1664 PF07889.7 EFE37647.1 - 0.11 12.2 1.5 4.3 7.1 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF724 PF05266.9 EFE37647.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Cpn10 PF00166.16 EFE37649.1 - 2.6e-23 81.7 0.0 4.5e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Fip1 PF05182.8 EFE37649.1 - 1.3e-21 75.6 1.7 2.3e-21 74.7 1.2 1.4 1 0 0 1 1 1 1 Fip1 motif BSP_II PF05432.6 EFE37649.1 - 0.0031 16.8 9.7 0.0055 16.0 6.7 1.4 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Spot_14 PF07084.7 EFE37649.1 - 0.31 10.9 2.0 0.53 10.1 1.4 1.3 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 Daxx PF03344.10 EFE37649.1 - 1.4 7.3 11.3 1.8 6.9 7.8 1.1 1 0 0 1 1 1 0 Daxx Family DUF2890 PF11081.3 EFE37649.1 - 2.2 8.3 10.7 3.8 7.5 7.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) CENP-B_dimeris PF09026.5 EFE37649.1 - 3.4 7.9 14.3 9.6 6.5 9.9 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain AF1Q PF15017.1 EFE37649.1 - 7 6.6 12.5 3.1 7.7 5.2 2.4 2 0 0 2 2 2 0 Drug resistance and apoptosis regulator MCPVI PF02993.9 EFE37649.1 - 8.2 6.5 9.8 14 5.7 6.8 1.4 1 0 0 1 1 1 0 Minor capsid protein VI Nop14 PF04147.7 EFE37649.1 - 10 3.9 17.6 13 3.5 12.2 1.1 1 0 0 1 1 1 0 Nop14-like family XAP5 PF04921.9 EFE37650.1 - 8.8e-77 257.8 0.0 3.2e-76 256.0 0.0 1.7 2 0 0 2 2 2 1 XAP5, circadian clock regulator DUF4603 PF15376.1 EFE37650.1 - 1.5 5.9 6.3 1.7 5.7 4.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) TCP PF03634.8 EFE37651.1 - 0.076 13.3 1.2 0.25 11.6 0.8 1.9 1 1 0 1 1 1 0 TCP family transcription factor Ndr PF03096.9 EFE37651.1 - 0.094 11.1 0.1 0.12 10.8 0.1 1.1 1 0 0 1 1 1 0 Ndr family DUF1031 PF06275.6 EFE37651.1 - 0.15 12.1 1.8 0.21 11.6 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) Lge1 PF11488.3 EFE37651.1 - 0.18 12.0 2.8 0.12 12.5 0.8 1.8 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 zf-C3HC4_3 PF13920.1 EFE37652.1 - 8.9e-09 34.8 12.2 1.6e-08 34.0 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FA_hydroxylase PF04116.8 EFE37653.1 - 7.5e-18 64.9 11.9 7.5e-18 64.9 8.2 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily UNC-79 PF14776.1 EFE37653.1 - 0.0095 14.3 0.0 0.014 13.7 0.0 1.2 1 0 0 1 1 1 1 Cation-channel complex subunit UNC-79 Aldo_ket_red PF00248.16 EFE37654.1 - 4.1e-57 193.1 0.0 4.9e-57 192.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Kelch_5 PF13854.1 EFE37655.1 - 2.7e-11 43.1 0.5 2.7e-11 43.1 0.4 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.1 EFE37655.1 - 8.9e-07 28.5 1.3 0.00064 19.4 0.1 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.1 EFE37655.1 - 5.3e-06 26.4 3.7 0.00035 20.6 0.1 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.20 EFE37655.1 - 0.00031 20.2 7.7 0.86 9.1 1.2 4.0 3 1 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 EFE37655.1 - 0.0034 17.4 4.2 0.024 14.8 0.2 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.10 EFE37655.1 - 0.033 13.9 0.3 7 6.5 0.1 3.7 3 1 0 3 3 3 0 Kelch motif BatA PF07584.6 EFE37655.1 - 0.15 12.3 0.1 0.27 11.4 0.1 1.3 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Pyr_redox_3 PF13738.1 EFE37657.1 - 5.6e-05 23.2 0.0 0.00018 21.6 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE37657.1 - 0.092 11.6 0.1 0.65 8.8 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pkinase PF00069.20 EFE37658.1 - 1.2e-23 83.6 0.0 1.1e-22 80.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37658.1 - 3.1e-09 36.3 0.0 0.21 10.6 0.0 3.7 4 0 0 4 4 4 3 Protein tyrosine kinase APH PF01636.18 EFE37658.1 - 0.056 13.1 1.0 0.16 11.6 0.1 2.2 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 EFE37658.1 - 0.11 11.4 0.1 5.7 5.8 0.1 2.8 3 0 0 3 3 3 0 Kinase-like Arf PF00025.16 EFE37659.1 - 1.8e-39 134.7 0.0 6.2e-26 90.6 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.15 EFE37659.1 - 2e-11 43.2 0.0 3e-05 22.8 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 EFE37659.1 - 6.7e-08 32.0 0.0 0.00041 19.7 0.0 2.3 2 0 0 2 2 2 2 Ras family GTP_EFTU PF00009.22 EFE37659.1 - 1.3e-07 31.2 0.0 4.9e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 EFE37659.1 - 3e-07 30.9 0.0 3.3e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 EFE37659.1 - 3.4e-07 29.6 0.0 4.9e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFE37659.1 - 5e-07 29.6 0.0 2.5e-05 24.2 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.5 EFE37659.1 - 1.2e-05 24.5 0.0 6.4e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 EFE37659.1 - 0.0074 15.7 0.0 0.036 13.5 0.0 2.0 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 EFE37659.1 - 0.039 13.2 0.0 0.093 11.9 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF397 PF04149.7 EFE37659.1 - 0.044 13.3 0.4 1.1 8.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF397) Glycos_transf_1 PF00534.15 EFE37660.1 - 7.1e-29 100.4 0.0 1.1e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 PIGA PF08288.7 EFE37660.1 - 2e-28 98.5 0.9 2e-28 98.5 0.7 1.9 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_trans_1_4 PF13692.1 EFE37660.1 - 1.6e-13 50.9 0.0 2.5e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EFE37660.1 - 1.4e-07 31.4 0.4 2.7e-07 30.4 0.3 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 EFE37660.1 - 0.00055 20.0 0.0 0.00099 19.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.1 EFE37660.1 - 0.00091 19.4 0.0 0.0025 18.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 DEAD PF00270.24 EFE37661.1 - 9.4e-36 122.8 0.1 2.2e-17 63.0 0.0 3.0 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE37661.1 - 1.7e-16 59.8 0.1 4e-16 58.6 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE37661.1 - 4.7e-08 33.0 0.1 5.5e-07 29.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 EFE37661.1 - 0.027 12.8 0.0 1.1 7.5 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1253) AAA_19 PF13245.1 EFE37661.1 - 0.093 12.4 1.4 3.4 7.4 0.5 2.9 2 0 0 2 2 2 0 Part of AAA domain Prp18 PF02840.10 EFE37662.1 - 8.1e-53 178.1 1.4 9e-53 178.0 0.0 1.8 2 1 0 2 2 2 1 Prp18 domain PRP4 PF08799.6 EFE37662.1 - 3.5e-12 45.3 2.1 3.5e-12 45.3 1.5 3.0 3 0 0 3 3 3 1 pre-mRNA processing factor 4 (PRP4) like CAF-1_p150 PF11600.3 EFE37662.1 - 0.43 9.9 31.7 0.69 9.2 22.0 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal MAP7 PF05672.6 EFE37662.1 - 0.73 9.1 42.8 1.3 8.3 29.7 1.3 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family CDC27 PF09507.5 EFE37662.1 - 1.5 7.9 26.9 0.57 9.3 16.9 1.5 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Ycf1 PF05758.7 EFE37662.1 - 3.1 5.3 7.6 3.1 5.3 5.3 1.1 1 0 0 1 1 1 0 Ycf1 SAP18 PF06487.7 EFE37663.1 - 9.4e-45 151.3 0.0 1.2e-44 150.9 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Nol1_Nop2_Fmu PF01189.12 EFE37664.1 - 1.9e-14 53.7 0.0 7.3e-09 35.3 0.0 2.3 2 0 0 2 2 2 2 NOL1/NOP2/sun family Acetyltransf_1 PF00583.19 EFE37665.1 - 2.4e-11 43.4 0.3 4.2e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.1 EFE37665.1 - 6.8e-08 33.0 0.0 4.7e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFE37665.1 - 3.1e-06 27.2 0.0 4.2e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFE37665.1 - 1.2e-05 25.0 0.0 2.1e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.1 EFE37665.1 - 5.4e-05 23.3 0.0 6.9e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE37665.1 - 0.00043 20.3 0.1 0.0011 19.0 0.0 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE37665.1 - 0.0035 17.2 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE37665.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein PmoA PF14100.1 EFE37665.1 - 0.032 13.4 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 Methane oxygenase PmoA FYVE PF01363.16 EFE37666.1 - 5.6e-13 48.5 4.3 1e-12 47.7 3.0 1.4 1 0 0 1 1 1 1 FYVE zinc finger IBR PF01485.16 EFE37666.1 - 0.032 14.1 0.8 0.071 12.9 0.5 1.5 1 0 0 1 1 1 0 IBR domain zf-AN1 PF01428.11 EFE37666.1 - 0.073 12.9 9.3 0.14 12.0 6.4 1.5 1 0 0 1 1 1 0 AN1-like Zinc finger FAD_binding_3 PF01494.14 EFE37668.1 - 1.3e-11 44.2 0.3 7e-08 31.8 0.0 2.7 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.19 EFE37668.1 - 1.9e-06 27.0 0.0 0.00016 20.6 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE37668.1 - 9.1e-06 25.6 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 EFE37668.1 - 0.00016 20.4 0.0 0.028 13.0 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_9 PF13454.1 EFE37668.1 - 0.00054 19.7 0.0 0.0085 15.8 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding SE PF08491.5 EFE37668.1 - 0.0043 15.9 0.0 0.0096 14.7 0.0 1.5 1 1 0 1 1 1 1 Squalene epoxidase Pyr_redox PF00070.22 EFE37668.1 - 0.093 13.1 0.0 0.27 11.6 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IDO PF01231.13 EFE37669.1 - 0.00011 20.7 0.0 0.00018 20.0 0.0 1.3 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase ABC2_membrane PF01061.19 EFE37670.1 - 1.6e-75 252.8 47.5 2.9e-41 140.9 12.3 3.6 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.22 EFE37670.1 - 3.9e-40 137.3 0.0 1.5e-18 67.4 0.0 3.5 4 0 0 4 4 4 2 ABC transporter PDR_CDR PF06422.7 EFE37670.1 - 1.6e-33 114.4 10.2 3.2e-28 97.4 0.0 3.4 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.1 EFE37670.1 - 1.7e-18 66.4 0.0 3.8e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 EFE37670.1 - 9.2e-09 34.9 0.0 3.4e-05 23.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 EFE37670.1 - 3.7e-08 33.3 0.2 0.0013 18.5 0.1 2.5 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 EFE37670.1 - 2.1e-06 27.0 16.2 2.1e-06 27.0 11.2 3.8 4 0 0 4 4 4 1 ABC-2 family transporter protein AAA_29 PF13555.1 EFE37670.1 - 2.2e-06 27.0 0.3 0.0016 17.9 0.1 2.9 3 0 0 3 3 3 1 P-loop containing region of AAA domain SMC_N PF02463.14 EFE37670.1 - 1e-05 24.9 0.0 0.11 11.6 0.0 3.6 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EFE37670.1 - 1.4e-05 24.3 0.1 0.00043 19.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFE37670.1 - 8.1e-05 23.4 0.0 0.034 14.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFE37670.1 - 9.2e-05 22.5 0.2 0.0025 17.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.14 EFE37670.1 - 0.00012 21.6 0.5 0.0012 18.3 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.1 EFE37670.1 - 0.0004 20.4 0.0 0.27 11.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.1 EFE37670.1 - 0.00048 20.4 0.1 0.018 15.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 EFE37670.1 - 0.0014 18.9 0.0 0.14 12.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain PDR_assoc PF08370.6 EFE37670.1 - 0.0018 17.7 1.2 2 7.9 0.0 3.1 2 0 0 2 2 2 1 Plant PDR ABC transporter associated AAA_22 PF13401.1 EFE37670.1 - 0.0021 18.2 0.2 0.16 12.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE37670.1 - 0.0023 17.6 0.1 2.2 8.1 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain MMR_HSR1 PF01926.18 EFE37670.1 - 0.0049 16.8 0.0 3.1 7.7 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.7 EFE37670.1 - 0.0079 15.8 1.8 0.99 9.0 0.2 2.7 2 0 0 2 2 2 1 NACHT domain Miro PF08477.8 EFE37670.1 - 0.01 16.3 0.0 4 7.9 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein AAA PF00004.24 EFE37670.1 - 0.019 15.1 0.1 3.6 7.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 EFE37670.1 - 0.029 13.9 0.5 1.2 8.7 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 EFE37670.1 - 0.052 13.7 0.0 21 5.3 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 EFE37670.1 - 0.083 12.8 0.3 0.21 11.5 0.2 1.6 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFE37670.1 - 0.086 12.2 0.1 4.6 6.6 0.0 2.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_10 PF12846.2 EFE37670.1 - 0.092 12.1 2.1 11 5.3 0.0 3.3 4 0 0 4 4 3 0 AAA-like domain AAA_30 PF13604.1 EFE37670.1 - 0.15 11.6 0.1 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 EFE37670.1 - 0.29 10.0 0.0 5.9 5.6 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_15 PF13175.1 EFE37670.1 - 1 8.3 0.0 2.6 7.0 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain RPAP1_C PF08620.5 EFE37671.1 - 6.5e-28 96.3 0.0 1.2e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 EFE37671.1 - 2.2e-12 46.3 7.4 4.3e-12 45.4 5.1 1.5 1 0 0 1 1 1 1 RPAP1-like, N-terminal Pellino PF04710.9 EFE37671.1 - 0.034 12.7 0.1 0.051 12.2 0.1 1.2 1 0 0 1 1 1 0 Pellino HUN PF08729.5 EFE37672.1 - 4.3e-13 48.9 0.0 9.8e-13 47.7 0.0 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain MFS_1 PF07690.11 EFE37673.1 - 1.6e-14 53.3 12.6 2.7e-13 49.3 7.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.6 EFE37673.1 - 1 9.1 7.3 4.4 7.0 1.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Fungal_trans_2 PF11951.3 EFE37674.1 - 1.7e-18 66.3 0.0 2.8e-18 65.6 0.0 1.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.3 EFE37675.1 - 2e-27 95.8 0.0 2.6e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Apc1 PF12859.2 EFE37676.1 - 1.7e-28 98.9 0.2 7.4e-28 96.8 0.1 2.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.17 EFE37676.1 - 8.5e-07 28.8 9.6 0.0062 16.7 0.1 4.8 5 0 0 5 5 5 3 Proteasome/cyclosome repeat PIP5K PF01504.13 EFE37678.1 - 1.1e-86 290.1 0.1 1.8e-86 289.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Pkinase PF00069.20 EFE37679.1 - 1.2e-21 76.9 0.0 7.2e-21 74.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37679.1 - 1.5e-05 24.2 0.1 3.2e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE37679.1 - 0.00085 18.3 0.0 0.024 13.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EFE37679.1 - 0.0094 15.7 0.1 0.056 13.1 0.0 1.9 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE37679.1 - 0.13 11.2 0.1 0.42 9.6 0.0 1.8 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EFE37680.1 - 1.2e-21 76.9 0.0 5e-17 61.9 0.0 2.7 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37680.1 - 1.5e-06 27.5 2.5 0.0084 15.2 0.0 3.9 3 1 1 4 4 4 3 Protein tyrosine kinase F-box-like PF12937.2 EFE37681.1 - 0.0045 16.6 0.1 0.016 14.8 0.1 2.0 1 0 0 1 1 1 1 F-box-like PRANC PF09372.5 EFE37681.1 - 0.14 12.1 0.0 32 4.5 0.0 2.8 2 0 0 2 2 2 0 PRANC domain Linker_histone PF00538.14 EFE37683.1 - 2.4e-14 53.1 0.7 8.2e-12 45.0 0.1 2.7 2 0 0 2 2 2 2 linker histone H1 and H5 family DUF650 PF04894.7 EFE37683.1 - 0.058 12.8 0.3 0.058 12.8 0.2 1.8 1 1 0 2 2 2 0 Archaeal protein of unknown function (DUF650) Nop14 PF04147.7 EFE37684.1 - 0.0014 16.6 5.7 0.0017 16.3 3.9 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2890 PF11081.3 EFE37684.1 - 0.27 11.2 6.1 0.45 10.5 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) XPG_I PF00867.13 EFE37686.1 - 7.6e-29 99.6 0.5 2e-28 98.2 0.0 2.0 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.12 EFE37686.1 - 4.5e-17 62.1 1.0 2.7e-15 56.4 0.0 2.9 2 1 1 3 3 3 1 XPG N-terminal domain 5_3_exonuc PF01367.15 EFE37686.1 - 6.3e-05 23.1 0.6 0.00028 21.0 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HXXSHH PF07586.6 EFE37686.1 - 0.064 12.1 3.2 0.13 11.1 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) DUF2229 PF09989.4 EFE37686.1 - 0.16 11.3 2.3 2.5 7.5 0.4 2.2 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Ras PF00071.17 EFE37687.1 - 7.5e-44 148.9 0.2 1.1e-43 148.4 0.1 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE37687.1 - 9.3e-11 42.2 0.0 1.9e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 EFE37687.1 - 2.7e-05 23.7 0.0 7.7e-05 22.2 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.16 EFE37687.1 - 0.01 15.0 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family 7tm_1 PF00001.16 EFE37687.1 - 0.026 13.6 5.9 0.084 11.9 3.0 2.2 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) FeoB_N PF02421.13 EFE37687.1 - 0.06 12.6 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF92 PF01940.11 EFE37687.1 - 0.16 11.1 1.6 0.31 10.1 1.1 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF92 DUF4519 PF15012.1 EFE37687.1 - 0.27 11.1 0.7 3.4 7.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) DUF788 PF05620.6 EFE37687.1 - 4.2 7.2 8.5 2.1 8.1 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF788) adh_short PF00106.20 EFE37688.1 - 3.5e-33 114.8 0.0 4e-33 114.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE37688.1 - 1e-14 54.9 0.0 1.2e-14 54.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE37688.1 - 4.5e-12 45.9 0.0 6.2e-12 45.5 0.0 1.2 1 1 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 EFE37688.1 - 3.9e-05 23.3 0.2 9.8e-05 22.0 0.1 1.8 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Polysacc_synt_2 PF02719.10 EFE37688.1 - 7.5e-05 21.7 0.2 0.0001 21.3 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EFE37688.1 - 0.0013 18.2 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFE37688.1 - 0.019 13.8 0.2 0.046 12.6 0.1 1.6 1 1 0 1 1 1 0 Male sterility protein Saccharop_dh PF03435.13 EFE37688.1 - 0.021 13.8 0.1 0.048 12.6 0.1 1.6 1 1 1 2 2 2 0 Saccharopine dehydrogenase DUF1776 PF08643.5 EFE37688.1 - 0.059 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Lin0512_fam PF09585.5 EFE37688.1 - 0.095 12.2 0.3 0.76 9.3 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) Treacle PF03546.9 EFE37689.1 - 0.08 11.7 10.4 0.12 11.1 7.2 1.2 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle GATA PF00320.22 EFE37690.1 - 2.4e-16 58.7 5.1 4.6e-16 57.8 3.5 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 EFE37690.1 - 0.01 15.1 0.6 0.019 14.2 0.4 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding RRN7 PF11781.3 EFE37690.1 - 0.03 13.8 0.2 0.066 12.7 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-Sec23_Sec24 PF04810.10 EFE37690.1 - 0.9 9.1 6.4 0.088 12.3 0.7 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Hid1 PF12722.2 EFE37690.1 - 5.2 4.6 8.3 9 3.8 5.7 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DAO PF01266.19 EFE37691.1 - 1.1e-23 83.7 0.2 9.7e-23 80.6 0.1 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFE37691.1 - 0.00098 19.4 0.6 0.0021 18.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFE37691.1 - 0.0015 18.4 0.1 0.0036 17.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.11 EFE37691.1 - 0.029 13.7 0.2 0.29 10.5 0.1 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DUF1188 PF06690.6 EFE37691.1 - 0.043 12.9 0.0 0.7 8.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) Saccharop_dh PF03435.13 EFE37691.1 - 0.06 12.3 0.2 0.13 11.2 0.1 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NAD_binding_7 PF13241.1 EFE37691.1 - 0.071 13.3 0.0 0.12 12.6 0.0 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding GMC_oxred_N PF00732.14 EFE37691.1 - 0.085 11.9 0.0 0.25 10.4 0.0 1.8 2 0 0 2 2 2 0 GMC oxidoreductase Thi4 PF01946.12 EFE37691.1 - 0.098 11.7 0.1 0.098 11.7 0.1 1.6 2 0 0 2 2 2 0 Thi4 family Glyco_transf_54 PF04666.8 EFE37693.1 - 4e-07 29.0 0.0 0.00019 20.2 0.0 3.0 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.12 EFE37693.1 - 0.018 14.7 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) OTU PF02338.14 EFE37694.1 - 5.1e-17 62.5 0.0 1.1e-16 61.5 0.0 1.5 1 1 0 1 1 1 1 OTU-like cysteine protease CUE PF02845.11 EFE37694.1 - 0.004 16.5 0.3 0.015 14.7 0.0 2.1 3 0 0 3 3 3 1 CUE domain YqcI_YcgG PF08892.6 EFE37695.1 - 1.6e-61 207.6 0.2 1.9e-61 207.3 0.1 1.1 1 0 0 1 1 1 1 YqcI/YcgG family MFS_1 PF07690.11 EFE37696.1 - 8e-20 70.8 40.5 3.5e-19 68.7 19.7 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37696.1 - 3e-06 26.0 4.2 6.8e-06 24.9 2.9 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter zf-rbx1 PF12678.2 EFE37697.1 - 4e-12 46.0 3.1 5.3e-12 45.6 2.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EFE37697.1 - 0.00036 20.3 2.0 0.00046 19.9 1.4 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PNRC PF15365.1 EFE37698.1 - 2.7e-06 27.2 3.2 2.7e-06 27.2 2.2 4.1 4 0 0 4 4 4 2 Proline-rich nuclear receptor coactivator DUF601 PF04642.7 EFE37698.1 - 0.63 9.3 12.2 1.8 7.8 8.5 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DUF1705 PF08019.7 EFE37700.1 - 0.016 14.7 1.8 0.016 14.7 1.2 2.9 2 2 0 2 2 2 0 Domain of unknown function (DUF1705) UPF0370 PF13980.1 EFE37700.1 - 0.091 12.5 3.5 0.53 10.1 0.9 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) Podoplanin PF05808.6 EFE37701.1 - 0.56 9.7 0.0 0.56 9.7 0.0 3.2 2 1 1 3 3 3 0 Podoplanin Git3 PF11710.3 EFE37703.1 - 6.9e-28 97.6 5.8 1.2e-27 96.7 4.0 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 EFE37703.1 - 3.8e-10 39.4 0.0 1.8e-09 37.2 0.0 2.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.16 EFE37703.1 - 2e-08 33.6 5.6 2e-08 33.6 3.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.6 EFE37703.1 - 0.0093 14.8 5.1 0.013 14.3 3.4 1.5 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor Velvet PF11754.3 EFE37704.1 - 2e-41 141.8 0.0 2.3e-41 141.6 0.0 1.1 1 0 0 1 1 1 1 Velvet factor SLH PF00395.15 EFE37705.1 - 0.84 9.4 5.4 0.44 10.3 2.1 1.7 1 1 1 2 2 2 0 S-layer homology domain RTA1 PF04479.8 EFE37707.1 - 6e-47 160.0 1.8 9e-47 159.4 1.2 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF4083 PF13314.1 EFE37707.1 - 0.077 12.8 0.8 0.24 11.2 0.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) DUF2636 PF11120.3 EFE37707.1 - 0.12 11.9 0.1 0.3 10.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2636) Fer2_3 PF13085.1 EFE37708.1 - 6.6e-32 109.6 0.0 1.1e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.1 EFE37708.1 - 1.1e-09 38.4 5.9 1.1e-09 38.4 4.1 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 EFE37708.1 - 1.1e-08 35.0 4.2 1.1e-08 35.0 2.9 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 EFE37708.1 - 0.00013 22.2 0.3 0.00013 22.2 0.2 2.7 1 1 2 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.1 EFE37708.1 - 0.0004 20.1 6.0 0.00041 20.0 2.0 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 EFE37708.1 - 0.00056 20.1 3.8 0.036 14.3 0.3 3.1 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 EFE37708.1 - 0.0016 18.7 3.7 0.0016 18.7 2.6 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.22 EFE37708.1 - 0.0043 16.7 0.3 0.0043 16.7 0.2 2.2 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain F_bP_aldolase PF01116.15 EFE37709.1 - 5.3e-84 281.7 0.0 5.9e-84 281.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II NAD_binding_11 PF14833.1 EFE37710.1 - 1.4e-41 141.3 0.2 3.8e-27 94.7 0.0 2.2 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.10 EFE37710.1 - 7.1e-37 126.7 0.0 1.2e-36 126.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 EFE37710.1 - 0.00034 20.3 0.1 0.0006 19.5 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EFE37710.1 - 0.00089 19.6 0.0 0.0027 18.0 0.0 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 EFE37710.1 - 0.0054 15.9 0.0 0.0092 15.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 EFE37710.1 - 0.017 14.5 0.1 0.033 13.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 EFE37710.1 - 0.037 13.3 0.0 6.7 6.0 0.0 2.3 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UPF0154 PF03672.8 EFE37714.1 - 0.019 14.6 0.2 0.48 10.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Helicase_C PF00271.26 EFE37715.1 - 6.7e-23 80.3 0.1 1.1e-11 44.3 0.0 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.24 EFE37715.1 - 2.3e-17 62.9 0.3 1.2e-15 57.4 0.1 2.7 2 1 1 3 3 3 2 DEAD/DEAH box helicase APH PF01636.18 EFE37716.1 - 2.4e-15 56.9 0.0 3.5e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE37716.1 - 0.092 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RNA_lig_T4_1 PF09511.5 EFE37719.1 - 4.6e-81 271.5 0.2 1.5e-79 266.5 0.0 2.5 2 0 0 2 2 2 1 RNA ligase tRNA_lig_CPD PF08302.6 EFE37719.1 - 4.5e-77 258.7 3.4 7.9e-54 182.5 1.5 2.2 2 0 0 2 2 2 2 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.6 EFE37719.1 - 3.7e-49 166.8 0.2 9.5e-49 165.4 0.0 1.8 2 0 0 2 2 2 1 tRNA ligase kinase domain AAA_23 PF13476.1 EFE37719.1 - 0.022 15.0 1.1 0.045 14.0 0.2 1.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 EFE37719.1 - 0.059 14.1 0.0 0.29 11.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain DEAD PF00270.24 EFE37720.1 - 5.7e-22 77.9 0.0 1.4e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE37720.1 - 9.2e-22 76.6 0.1 2.9e-18 65.5 0.0 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RQC PF09382.5 EFE37720.1 - 8e-13 48.0 0.0 1.9e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 RQC domain ResIII PF04851.10 EFE37720.1 - 2.4e-05 24.2 0.1 0.00019 21.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EFE37720.1 - 0.00079 18.3 0.0 0.0013 17.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4110 PF13422.1 EFE37721.1 - 5.8e-29 99.7 0.2 5.8e-29 99.7 0.2 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_3 PF13415.1 EFE37721.1 - 5.8e-26 90.0 9.5 2.6e-09 36.9 0.0 6.7 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_4 PF13418.1 EFE37721.1 - 2.7e-22 78.2 17.0 1.5e-08 34.2 0.0 7.1 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_6 PF13964.1 EFE37721.1 - 4.5e-17 61.4 4.6 0.00037 20.5 0.1 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 EFE37721.1 - 1.1e-16 60.3 4.0 3.4e-06 26.8 0.0 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 EFE37721.1 - 2.8e-12 45.8 5.0 0.00076 19.1 0.0 6.0 6 1 0 6 6 6 3 Kelch motif Kelch_1 PF01344.20 EFE37721.1 - 1.7e-11 43.5 2.2 3.9e-06 26.3 0.1 4.4 4 0 0 4 4 4 2 Kelch motif Nucleoplasmin PF03066.10 EFE37721.1 - 10 5.6 16.1 0.28 10.7 5.7 2.4 3 0 0 3 3 3 0 Nucleoplasmin Pyridoxal_deC PF00282.14 EFE37722.1 - 4.9e-25 87.7 0.0 3.1e-24 85.1 0.0 1.9 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 EFE37722.1 - 0.026 13.6 0.0 0.044 12.9 0.0 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase Chitin_bind_3 PF03067.10 EFE37723.1 - 0.016 15.4 0.0 0.044 14.0 0.0 1.9 1 1 0 1 1 1 0 Chitin binding domain Glyco_hydro_61 PF03443.9 EFE37723.1 - 0.067 13.0 0.0 0.57 9.9 0.0 2.2 2 1 0 2 2 2 0 Glycosyl hydrolase family 61 AF1Q PF15017.1 EFE37724.1 - 0.0054 16.6 0.4 0.0065 16.3 0.3 1.1 1 0 0 1 1 1 1 Drug resistance and apoptosis regulator Bd3614_N PF14442.1 EFE37724.1 - 0.056 13.4 2.4 0.065 13.2 1.6 1.1 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal CENP-B_dimeris PF09026.5 EFE37724.1 - 0.12 12.6 2.1 0.13 12.5 1.4 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CUE PF02845.11 EFE37727.1 - 2e-10 39.9 0.0 3.4e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain ELK PF03789.8 EFE37727.1 - 0.024 14.4 0.2 0.044 13.5 0.2 1.3 1 0 0 1 1 1 0 ELK domain HIRAN PF08797.6 EFE37727.1 - 0.076 12.9 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 HIRAN domain DUF4199 PF13858.1 EFE37727.1 - 1.4 8.7 2.0 3.5 7.5 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) RTA1 PF04479.8 EFE37728.1 - 9e-26 90.7 8.2 3.7e-25 88.7 5.7 1.8 1 1 0 1 1 1 1 RTA1 like protein Oxysterol_BP PF01237.13 EFE37729.1 - 3.6e-89 298.7 0.0 4.4e-89 298.4 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Kinesin-relat_1 PF12711.2 EFE37729.1 - 0.011 16.1 0.1 0.038 14.3 0.0 1.8 2 1 0 2 2 2 0 Kinesin motor Suf PF05843.9 EFE37730.1 - 9.2e-89 297.8 0.0 9.2e-89 297.8 0.0 3.9 4 1 0 4 4 4 1 Suppressor of forked protein (Suf) TPR_14 PF13428.1 EFE37730.1 - 0.00015 22.0 0.0 0.043 14.4 0.0 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat HAT PF02184.11 EFE37730.1 - 0.0006 19.5 0.1 0.0026 17.4 0.0 2.2 1 0 0 1 1 1 1 HAT (Half-A-TPR) repeat TPR_16 PF13432.1 EFE37730.1 - 0.001 19.7 0.0 0.11 13.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat ASF1_hist_chap PF04729.8 EFE37731.1 - 3.9e-56 188.9 0.0 6.6e-56 188.2 0.0 1.4 1 0 0 1 1 1 1 ASF1 like histone chaperone DUF4407 PF14362.1 EFE37731.1 - 0.15 11.0 3.8 0.19 10.6 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nop14 PF04147.7 EFE37731.1 - 6.2 4.6 25.2 8.5 4.1 17.5 1.1 1 0 0 1 1 1 0 Nop14-like family Pex19 PF04614.7 EFE37732.1 - 3.6e-59 200.3 31.1 1.9e-58 198.0 21.5 2.0 1 1 0 1 1 1 1 Pex19 protein family Gluconate_2-dh3 PF13618.1 EFE37732.1 - 0.0011 19.0 9.4 0.067 13.3 1.1 3.3 2 2 0 2 2 2 2 Gluconate 2-dehydrogenase subunit 3 DUF4327 PF14217.1 EFE37732.1 - 0.012 15.4 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4327) DUF4591 PF15261.1 EFE37733.1 - 0.0048 17.1 0.7 0.0092 16.2 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4591) CENP-H PF05837.7 EFE37734.1 - 2.8e-22 78.8 9.0 2.8e-22 78.8 6.2 2.2 2 1 0 2 2 2 1 Centromere protein H (CENP-H) PGBA_C PF15437.1 EFE37734.1 - 0.075 13.1 3.0 0.18 11.9 2.0 1.7 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal TSC22 PF01166.13 EFE37734.1 - 5.8 6.9 10.1 2.8 7.9 0.2 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family ATG11 PF10377.4 EFE37735.1 - 4.8e-41 139.6 0.0 3.2e-40 137.0 0.0 2.6 1 0 0 1 1 1 1 Autophagy-related protein 11 APG17 PF04108.7 EFE37735.1 - 3.4e-07 29.4 0.1 3.4e-07 29.4 0.0 4.3 2 2 1 3 3 3 1 Autophagy protein Apg17 AAA_13 PF13166.1 EFE37735.1 - 6e-05 21.7 17.8 6e-05 21.7 12.4 4.8 2 1 2 4 4 4 3 AAA domain Atg14 PF10186.4 EFE37735.1 - 0.0016 17.4 16.4 0.0016 17.4 11.4 4.9 4 2 0 4 4 4 1 UV radiation resistance protein and autophagy-related subunit 14 DUF4078 PF13300.1 EFE37736.1 - 7.6e-32 109.2 9.7 7.6e-32 109.2 6.7 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) Homoserine_dh PF00742.14 EFE37737.1 - 1.9e-50 170.9 0.0 2.5e-50 170.6 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 EFE37737.1 - 5.8e-11 42.8 0.0 1.4e-10 41.6 0.0 1.7 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain RecO_N PF11967.3 EFE37737.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Recombination protein O N terminal p450 PF00067.17 EFE37738.1 - 5.8e-38 130.5 0.0 1.3e-37 129.3 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 DEAD PF00270.24 EFE37740.1 - 4.6e-44 149.8 0.0 1.2e-43 148.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EFE37740.1 - 3.6e-22 77.6 0.2 8.6e-22 76.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Ribosomal_L22 PF00237.14 EFE37740.1 - 4.1e-15 55.6 1.7 6.7e-08 32.4 0.1 2.7 3 0 0 3 3 3 2 Ribosomal protein L22p/L17e Helicase_C PF00271.26 EFE37740.1 - 2.7e-13 49.5 0.0 3e-12 46.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Oxysterol_BP PF01237.13 EFE37742.1 - 2.7e-47 160.9 2.9 2.1e-43 148.1 0.0 3.1 3 1 0 3 3 3 2 Oxysterol-binding protein DUF1183 PF06682.7 EFE37742.1 - 0.00031 20.4 1.5 0.0027 17.3 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF1183) Mucin PF01456.12 EFE37742.1 - 0.24 11.1 0.1 0.24 11.1 0.0 2.6 3 0 0 3 3 3 0 Mucin-like glycoprotein Trypan_PARP PF05887.6 EFE37742.1 - 0.33 10.7 0.0 0.33 10.7 0.0 2.6 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF3439 PF11921.3 EFE37742.1 - 0.38 10.5 12.0 1.9 8.2 3.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Cnd1_N PF12922.2 EFE37743.1 - 8.8e-57 191.4 0.7 2.9e-56 189.7 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.2 EFE37743.1 - 1.2e-43 149.0 9.1 1.6e-41 142.0 0.6 3.2 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EFE37743.1 - 1.2e-09 38.3 10.3 2.9e-05 24.2 0.0 5.4 5 1 0 5 5 5 2 HEAT repeats HEAT PF02985.17 EFE37743.1 - 4.2e-07 29.4 11.7 0.063 13.3 0.0 6.8 9 0 0 9 9 9 2 HEAT repeat Adaptin_N PF01602.15 EFE37743.1 - 7e-07 27.9 5.8 0.00034 19.0 0.1 3.9 4 0 0 4 4 4 2 Adaptin N terminal region HEAT_EZ PF13513.1 EFE37743.1 - 9.2e-06 25.9 7.6 0.096 13.2 0.0 5.9 5 0 0 5 5 5 2 HEAT-like repeat DUF2435 PF10363.4 EFE37743.1 - 0.00011 22.0 0.1 4.6 7.2 0.0 4.3 3 1 0 3 3 3 2 Protein of unknown function (DUF2435) Cohesin_HEAT PF12765.2 EFE37743.1 - 0.015 15.2 3.0 7.5 6.6 0.1 4.6 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion VHS PF00790.14 EFE37743.1 - 0.065 12.8 1.1 3.6 7.1 0.0 3.3 3 0 0 3 3 3 0 VHS domain Cnd3 PF12719.2 EFE37743.1 - 0.25 10.2 9.4 0.1 11.5 1.2 3.9 4 1 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain Pkinase PF00069.20 EFE37744.1 - 4.7e-38 130.8 0.0 6.5e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37744.1 - 2.6e-13 49.6 0.0 5.6e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE37744.1 - 8.1e-07 28.2 0.0 3e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EFE37744.1 - 0.00076 19.2 0.3 0.19 11.4 0.0 3.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family PCMT PF01135.14 EFE37745.1 - 2.1e-48 164.6 0.0 7.4e-48 162.8 0.0 1.7 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 EFE37745.1 - 4.9e-10 39.9 0.0 7.4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE37745.1 - 1.6e-07 31.0 0.1 2.5e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE37745.1 - 1.5e-06 27.9 0.0 2.3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE37745.1 - 5.8e-05 23.1 0.0 9.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EFE37745.1 - 7.3e-05 22.4 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE37745.1 - 0.00032 21.1 0.0 0.00049 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE37745.1 - 0.0017 17.7 0.0 0.0031 16.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 EFE37745.1 - 0.0074 15.6 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.1 EFE37745.1 - 0.009 16.3 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE37745.1 - 0.0094 16.4 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFE37745.1 - 0.014 14.5 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 EFE37745.1 - 0.026 13.5 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.1 EFE37745.1 - 0.032 15.0 0.1 0.17 12.7 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_9 PF08003.6 EFE37745.1 - 0.12 11.0 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DnaJ PF00226.26 EFE37746.1 - 6.3e-25 86.6 0.7 1.8e-24 85.2 0.5 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_11 PF13414.1 EFE37746.1 - 5.7e-22 77.1 0.5 3.2e-09 36.3 0.1 5.4 4 1 1 5 5 5 3 TPR repeat TPR_2 PF07719.12 EFE37746.1 - 2.4e-19 67.6 0.0 0.00029 20.5 0.0 6.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 EFE37746.1 - 1.6e-17 62.2 0.6 8e-06 25.2 0.0 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_9 PF13371.1 EFE37746.1 - 6.9e-15 54.6 0.4 0.00014 21.5 0.0 4.6 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFE37746.1 - 1.1e-14 53.6 0.2 0.045 14.3 0.1 7.3 2 2 4 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFE37746.1 - 3e-12 46.8 1.1 2.7e-05 24.7 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFE37746.1 - 1.6e-10 40.0 0.1 0.0089 15.7 0.0 6.8 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFE37746.1 - 3.2e-09 36.9 0.5 0.12 12.7 0.2 4.8 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 EFE37746.1 - 3.7e-07 30.1 4.4 5.7 7.6 0.0 7.2 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFE37746.1 - 6e-07 29.1 0.2 0.032 14.4 0.0 6.0 5 2 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 EFE37746.1 - 1.3e-05 25.2 1.3 0.43 10.7 0.0 4.4 4 1 2 6 6 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EFE37746.1 - 2.2e-05 24.2 0.5 0.77 9.7 0.0 5.0 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE37746.1 - 0.00039 19.9 0.1 17 5.4 0.0 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF3856 PF12968.2 EFE37746.1 - 0.044 13.6 3.1 6.4 6.5 0.0 3.8 5 1 0 5 5 5 0 Domain of Unknown Function (DUF3856) SLS PF14611.1 EFE37746.1 - 0.13 11.7 0.9 0.26 10.7 0.3 1.7 2 0 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator RF-1 PF00472.15 EFE37747.1 - 2.4e-33 114.3 0.9 6.1e-33 113.0 0.7 1.7 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.13 EFE37747.1 - 1.2e-26 92.7 0.0 6e-26 90.4 0.0 2.1 2 0 0 2 2 2 1 PCRF domain HHA PF05321.6 EFE37747.1 - 0.56 10.3 2.6 28 4.9 0.0 3.1 3 0 0 3 3 3 0 Haemolysin expression modulating protein Abdominal-A PF12407.3 EFE37747.1 - 1.3 8.5 7.6 3 7.4 5.3 1.5 1 0 0 1 1 1 0 Homeobox protein Mito_carr PF00153.22 EFE37748.1 - 5.8e-34 115.6 3.8 1.4e-17 63.1 0.1 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein DEAD PF00270.24 EFE37749.1 - 1.3e-41 141.9 0.2 1.9e-41 141.3 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE37749.1 - 9.1e-24 83.1 0.1 1.7e-23 82.2 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2454 PF10521.4 EFE37749.1 - 0.02 13.8 1.9 0.066 12.2 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2454) CMS1 PF14617.1 EFE37749.1 - 0.022 13.8 0.1 0.051 12.6 0.1 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit SMC_N PF02463.14 EFE37750.1 - 3.7e-17 62.3 0.0 2.4e-16 59.6 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFE37750.1 - 3.1e-11 43.9 19.7 3.1e-11 43.9 13.6 5.0 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.1 EFE37750.1 - 2.8e-06 27.4 0.3 3.3e-05 23.9 0.2 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EFE37750.1 - 0.00028 20.3 0.0 0.00094 18.6 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_15 PF13175.1 EFE37750.1 - 0.00054 19.1 0.0 0.00054 19.1 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.1 EFE37750.1 - 0.001 18.9 0.0 0.0031 17.3 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.1 EFE37750.1 - 0.078 11.4 62.4 0.014 13.9 4.2 4.8 4 1 1 5 5 5 0 AAA domain ABC_tran PF00005.22 EFE37750.1 - 0.094 13.0 0.2 0.094 13.0 0.2 5.6 4 2 1 5 5 5 0 ABC transporter NUDIX PF00293.23 EFE37751.1 - 1.4e-12 47.4 0.3 4.1e-12 45.9 0.2 1.6 1 1 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.1 EFE37751.1 - 0.0018 17.6 0.0 0.016 14.5 0.0 2.1 2 1 0 2 2 2 1 NUDIX domain SNARE PF05739.14 EFE37754.1 - 4.7e-17 61.4 0.6 4.7e-17 61.4 0.4 2.3 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 EFE37754.1 - 4.7e-15 55.6 0.1 4.7e-15 55.6 0.1 3.0 3 0 0 3 3 3 1 Syntaxin MCPsignal PF00015.16 EFE37754.1 - 0.0033 16.9 0.7 0.027 14.0 0.2 2.2 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain AAA_10 PF12846.2 EFE37755.1 - 1.8e-08 34.1 0.2 2.8e-05 23.7 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain Zot PF05707.7 EFE37755.1 - 0.0012 18.3 0.0 0.054 12.9 0.0 3.0 3 0 0 3 3 3 1 Zonular occludens toxin (Zot) Plasmodium_Vir PF05795.6 EFE37755.1 - 0.0035 16.6 0.2 0.0035 16.6 0.1 1.5 2 0 0 2 2 2 1 Plasmodium vivax Vir protein SID-1_RNA_chan PF13965.1 EFE37755.1 - 0.012 13.8 0.3 0.019 13.1 0.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AAA_22 PF13401.1 EFE37755.1 - 0.031 14.4 0.1 10 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 EFE37755.1 - 0.036 14.2 0.0 0.099 12.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) 7tm_1 PF00001.16 EFE37755.1 - 0.076 12.1 0.1 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Trypan_PARP PF05887.6 EFE37755.1 - 2.6 7.8 6.8 0.46 10.3 1.5 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Glyco_hydro_18 PF00704.23 EFE37756.1 - 2.5e-15 56.7 2.5 1.1e-14 54.6 0.1 2.0 1 1 1 2 2 2 2 Glycosyl hydrolases family 18 adh_short PF00106.20 EFE37757.1 - 1.8e-25 89.8 1.2 2.2e-25 89.5 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE37757.1 - 2.3e-10 40.4 0.2 3.3e-10 39.9 0.2 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE37757.1 - 1.9e-07 31.0 0.0 2.7e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EFE37757.1 - 0.00015 21.3 0.2 0.00085 18.8 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFE37757.1 - 0.0028 16.5 0.0 0.0042 16.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 EFE37757.1 - 0.073 12.8 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 EFE37757.1 - 0.093 12.7 0.8 0.33 10.9 0.6 1.8 1 1 0 1 1 1 0 NADH(P)-binding Ion_trans_2 PF07885.11 EFE37758.1 - 3.7e-24 84.2 25.1 1.1e-14 53.8 5.2 3.3 3 0 0 3 3 3 2 Ion channel ATP-grasp_4 PF13535.1 EFE37760.1 - 4.8e-22 78.5 0.0 1.7e-19 70.2 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFE37760.1 - 4e-08 32.8 0.0 8.1e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 EFE37760.1 - 1.5e-07 30.4 0.0 1.8e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 EFE37760.1 - 0.00036 20.4 0.0 0.0022 17.8 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.12 EFE37760.1 - 0.022 14.0 0.0 0.096 11.9 0.0 2.0 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain RTA1 PF04479.8 EFE37761.1 - 3.3e-38 131.4 6.6 5.1e-38 130.8 4.6 1.3 1 1 0 1 1 1 1 RTA1 like protein DUF3040 PF11239.3 EFE37761.1 - 0.0098 15.9 7.2 0.5 10.4 0.3 2.9 3 1 0 3 3 3 2 Protein of unknown function (DUF3040) NfeD PF01957.13 EFE37761.1 - 0.26 11.4 0.1 0.26 11.4 0.1 2.9 1 1 1 3 3 3 0 NfeD-like C-terminal, partner-binding DUF1011 PF06237.7 EFE37761.1 - 0.28 11.0 3.6 0.31 10.9 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) DctQ PF04290.7 EFE37761.1 - 3.3 7.4 19.5 8.4 6.1 0.4 3.2 2 1 1 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF3433 PF11915.3 EFE37762.1 - 1.5e-29 101.9 21.8 5.9e-25 87.2 2.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) Pkinase PF00069.20 EFE37763.1 - 7.7e-21 74.3 0.0 1.2e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37763.1 - 1.8e-10 40.3 0.2 4.3e-09 35.8 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 EFE37765.1 - 9.1e-11 41.3 0.0 1.1e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37765.1 - 0.0025 16.9 0.0 0.0045 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FAD-SLDH PF12318.3 EFE37766.1 - 1.3 8.6 3.7 0.43 10.2 0.3 1.7 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase ESR1_C PF12743.2 EFE37766.1 - 3.8 7.1 9.3 10 5.7 6.4 1.7 1 0 0 1 1 1 0 Oestrogen-type nuclear receptor final C-terminal G-patch PF01585.18 EFE37767.1 - 1.8e-09 37.2 3.1 4e-09 36.1 2.1 1.6 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.17 EFE37767.1 - 1.2e-08 34.4 0.0 0.00029 20.3 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE37767.1 - 8.8e-08 32.0 0.0 0.015 15.2 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.2 EFE37767.1 - 0.00051 19.8 1.7 0.00051 19.8 1.2 2.3 2 0 0 2 2 2 1 DExH-box splicing factor binding site Rad50_zn_hook PF04423.9 EFE37767.1 - 0.048 13.1 0.2 0.14 11.6 0.2 1.7 1 0 0 1 1 1 0 Rad50 zinc hook motif RRM_5 PF13893.1 EFE37767.1 - 0.049 13.4 0.0 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC_tran PF00005.22 EFE37769.1 - 2.8e-51 173.4 0.0 6.8e-31 107.3 0.0 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFE37769.1 - 1.1e-16 61.0 18.7 3.7e-16 59.3 3.9 4.1 3 1 1 4 4 4 1 ABC transporter transmembrane region AAA_21 PF13304.1 EFE37769.1 - 2.4e-10 40.8 0.1 0.53 10.1 0.1 4.4 3 1 1 4 4 4 4 AAA domain SMC_N PF02463.14 EFE37769.1 - 7.8e-09 35.0 1.5 0.0048 16.1 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EFE37769.1 - 1.4e-07 30.9 0.9 0.015 14.8 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE37769.1 - 1.9e-07 31.2 0.1 0.0073 16.3 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.12 EFE37769.1 - 3.9e-06 26.8 5.5 0.00041 20.2 0.2 3.0 3 0 0 3 3 3 2 Domain of unknown function DUF87 AAA_25 PF13481.1 EFE37769.1 - 8.2e-06 25.3 0.1 0.098 12.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFE37769.1 - 1.4e-05 25.2 0.4 0.31 11.1 0.0 3.4 2 1 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFE37769.1 - 4.5e-05 22.6 0.7 0.29 10.3 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 EFE37769.1 - 6.8e-05 23.3 1.1 0.041 14.3 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein T2SE PF00437.15 EFE37769.1 - 0.00012 21.0 0.3 0.33 9.8 0.0 2.6 3 0 0 3 3 2 2 Type II/IV secretion system protein Dynamin_N PF00350.18 EFE37769.1 - 0.00015 21.6 0.1 0.051 13.4 0.0 2.4 2 0 0 2 2 2 1 Dynamin family FtsK_SpoIIIE PF01580.13 EFE37769.1 - 0.0002 20.9 0.7 0.4 10.1 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_23 PF13476.1 EFE37769.1 - 0.00021 21.6 0.4 0.57 10.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EFE37769.1 - 0.00024 20.6 2.9 0.14 11.5 0.2 2.5 2 1 0 2 2 2 2 AAA-like domain AAA_17 PF13207.1 EFE37769.1 - 0.00027 21.7 0.2 1.6 9.5 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EFE37769.1 - 0.00056 20.2 0.1 1.6 9.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFE37769.1 - 0.00084 19.2 0.0 0.66 9.9 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.1 EFE37769.1 - 0.0023 17.8 0.2 2.7 7.8 0.2 2.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EFE37769.1 - 0.0027 17.3 0.4 0.73 9.5 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.1 EFE37769.1 - 0.0029 17.4 0.1 2.3 8.2 0.0 2.7 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.17 EFE37769.1 - 0.013 14.4 0.1 0.24 10.2 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.7 EFE37769.1 - 0.026 13.6 0.2 3.1 6.8 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin DUF815 PF05673.8 EFE37769.1 - 0.027 13.3 0.2 1.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) cobW PF02492.14 EFE37769.1 - 0.028 13.8 1.1 1 8.7 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Arch_ATPase PF01637.13 EFE37769.1 - 0.03 14.0 0.1 1.8 8.1 0.0 2.5 2 1 0 2 2 2 0 Archaeal ATPase AAA PF00004.24 EFE37769.1 - 0.034 14.3 0.9 23 5.1 0.0 4.0 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 EFE37769.1 - 0.05 13.1 1.2 4.8 6.6 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 EFE37769.1 - 0.051 13.7 0.1 7.1 6.8 0.0 2.7 2 0 0 2 2 2 0 RNA helicase TrwB_AAD_bind PF10412.4 EFE37769.1 - 0.073 11.6 0.7 5.3 5.5 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain UPF0079 PF02367.12 EFE37769.1 - 0.095 12.3 0.9 3.4 7.3 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 GTP_EFTU PF00009.22 EFE37769.1 - 0.15 11.4 0.8 28 4.0 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Adeno_IVa2 PF02456.10 EFE37769.1 - 0.15 10.6 0.2 7 5.1 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_24 PF13479.1 EFE37769.1 - 0.19 11.2 0.4 30 4.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.16 EFE37769.1 - 0.2 10.7 0.2 2.8 7.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_ATPase PF09818.4 EFE37769.1 - 4.6 5.7 4.4 4.6 5.6 0.1 2.8 4 0 0 4 4 4 0 Predicted ATPase of the ABC class DUF4106 PF13388.1 EFE37770.1 - 0.011 14.7 0.2 0.012 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) AMP-binding PF00501.23 EFE37771.1 - 1.2e-174 580.5 0.0 4.3e-79 265.8 0.0 3.6 3 1 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.15 EFE37771.1 - 6.3e-106 353.5 0.0 9.5e-36 123.1 0.2 4.4 3 1 0 3 3 3 3 Condensation domain PP-binding PF00550.20 EFE37771.1 - 8.2e-24 83.6 0.1 1.2e-13 51.0 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE37771.1 - 0.00014 22.7 1.9 0.093 13.6 0.0 3.1 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain Amidase PF01425.16 EFE37772.1 - 7.7e-38 130.4 1.0 1.5e-37 129.4 0.7 1.5 1 1 0 1 1 1 1 Amidase Amino_oxidase PF01593.19 EFE37773.1 - 8.6e-29 100.8 0.2 6.6e-18 65.0 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EFE37773.1 - 1e-06 28.6 0.0 2.3e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFE37773.1 - 0.0012 18.9 0.0 0.0032 17.5 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFE37773.1 - 0.049 12.6 0.2 0.089 11.8 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.22 EFE37773.1 - 0.051 13.9 0.4 0.13 12.7 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_1 PF00561.15 EFE37774.1 - 1e-08 35.0 0.0 2.5e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 EFE37774.1 - 3.3e-08 33.3 0.0 5.8e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_6 PF12697.2 EFE37774.1 - 0.0014 18.5 0.0 0.0036 17.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Beta-lactamase PF00144.19 EFE37775.1 - 3.6e-43 147.8 0.0 5.2e-43 147.3 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.3 EFE37775.1 - 3.2e-10 39.7 0.0 6.5e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Ank_2 PF12796.2 EFE37776.1 - 1.3e-55 185.6 0.1 2.1e-15 56.8 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EFE37776.1 - 1.4e-48 160.2 0.5 5.9e-10 38.4 0.0 7.1 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 EFE37776.1 - 5.2e-38 128.7 1.4 8.5e-10 38.8 0.0 5.7 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE37776.1 - 1.4e-35 117.7 0.1 1.2e-05 25.0 0.0 7.1 7 0 0 7 7 6 6 Ankyrin repeat Ank_5 PF13857.1 EFE37776.1 - 5.5e-35 118.6 0.9 2.3e-10 40.3 0.0 6.2 1 1 5 6 6 6 6 Ankyrin repeats (many copies) NACHT PF05729.7 EFE37776.1 - 7.9e-12 45.1 0.0 1.8e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EFE37776.1 - 7.1e-05 22.8 0.0 0.0003 20.8 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 EFE37776.1 - 0.0019 18.1 0.0 0.0051 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.17 EFE37776.1 - 0.013 14.3 0.0 0.031 13.1 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.1 EFE37776.1 - 0.022 14.8 0.0 0.067 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFE37776.1 - 0.038 14.1 0.0 0.093 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.4 EFE37776.1 - 0.06 12.3 0.0 0.14 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF2404 PF10296.4 EFE37776.1 - 0.071 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative integral membrane protein conserved region (DUF2404) AAA PF00004.24 EFE37776.1 - 0.074 13.2 0.0 0.23 11.6 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) APH PF01636.18 EFE37778.1 - 1.2e-10 41.6 0.0 7.9e-10 38.8 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFE37778.1 - 2.7e-06 26.7 0.1 7e-05 22.1 0.0 2.1 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.15 EFE37778.1 - 7.6e-05 22.3 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 EFE37778.1 - 0.0055 15.4 0.0 0.021 13.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Pkinase PF00069.20 EFE37779.1 - 6.2e-05 22.2 0.0 9.7e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 EFE37779.1 - 7.8e-05 22.1 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 EFE37779.1 - 0.00028 19.9 0.0 0.00049 19.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE37779.1 - 0.001 18.7 0.1 0.0017 17.9 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 EFE37779.1 - 0.0013 18.5 1.6 0.0027 17.4 0.3 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 EFE37779.1 - 0.0059 15.8 0.0 0.0093 15.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 EFE37779.1 - 0.099 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like GDC-P PF02347.11 EFE37780.1 - 1.4e-171 570.9 0.1 1.3e-158 528.2 0.0 2.6 3 1 0 3 3 3 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.16 EFE37780.1 - 1.8e-08 33.8 0.1 3.4e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EFE37780.1 - 0.0053 15.8 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_3 PF00202.16 EFE37780.1 - 0.0064 15.3 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III Pyridoxal_deC PF00282.14 EFE37781.1 - 1.8e-114 382.0 0.0 2.1e-114 381.8 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 EFE37781.1 - 0.003 16.7 0.0 0.0062 15.7 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Abhydrolase_6 PF12697.2 EFE37782.1 - 1.7e-18 67.3 0.1 2e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE37782.1 - 2.8e-11 43.3 0.2 4e-11 42.8 0.1 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.8 EFE37782.1 - 0.036 13.6 0.0 0.31 10.6 0.0 2.1 1 1 0 1 1 1 0 Serine hydrolase MBOAT_2 PF13813.1 EFE37783.1 - 1.5e-21 76.2 2.4 1.5e-21 76.2 0.4 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Glyco_hydro_65m PF03632.10 EFE37784.1 - 3.8e-82 275.9 1.1 2e-81 273.5 0.7 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 EFE37784.1 - 4.3e-46 157.2 0.0 7.2e-46 156.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.10 EFE37784.1 - 4.6e-05 23.4 0.2 0.00012 22.0 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain Pkinase PF00069.20 EFE37785.1 - 2.8e-08 33.2 0.0 6.1e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37785.1 - 9.5e-08 31.4 0.0 8e-07 28.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE37785.1 - 0.00028 20.6 0.2 0.00061 19.5 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE37785.1 - 0.00042 19.9 0.1 0.0011 18.5 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.9 EFE37785.1 - 0.00078 18.5 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE37785.1 - 0.0038 16.2 0.0 0.0055 15.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EFE37785.1 - 0.006 15.4 0.0 0.0088 14.9 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.17 EFE37785.1 - 0.025 13.9 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Ank_2 PF12796.2 EFE37786.1 - 3.7e-18 65.6 0.0 1.8e-06 28.1 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFE37786.1 - 1.4e-16 59.3 1.8 4.7e-05 22.9 0.0 6.4 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.1 EFE37786.1 - 3e-13 49.8 0.4 7.4e-06 26.3 0.0 4.9 4 2 0 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE37786.1 - 5.2e-12 45.6 1.9 0.00043 20.4 0.1 4.7 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE37786.1 - 1e-10 40.7 1.4 0.01 16.0 0.0 5.8 6 0 0 6 6 6 2 Ankyrin repeat DUF2202 PF09968.4 EFE37786.1 - 0.066 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) Filo_VP35 PF02097.10 EFE37787.1 - 0.067 12.3 0.0 0.078 12.1 0.0 1.0 1 0 0 1 1 1 0 Filoviridae VP35 SMC_Nse1 PF07574.8 EFE37788.1 - 2.2e-30 105.7 0.0 2.8e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex PaaX PF07848.7 EFE37788.1 - 0.0015 18.4 0.4 0.004 17.1 0.1 1.8 2 0 0 2 2 2 1 PaaX-like protein Mrr_N PF14338.1 EFE37788.1 - 0.068 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Mrr N-terminal domain DUF4095 PF13338.1 EFE37788.1 - 0.084 13.0 0.1 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4095) DAO PF01266.19 EFE37789.1 - 3.3e-38 131.5 0.2 4e-38 131.2 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFE37789.1 - 0.0026 18.1 0.1 0.048 14.0 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE37789.1 - 0.004 17.0 0.0 0.7 9.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFE37789.1 - 0.0079 16.2 0.1 0.019 14.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFE37789.1 - 0.0093 15.7 0.1 0.023 14.4 0.1 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding DUF4066 PF13278.1 EFE37790.1 - 1.2e-31 109.2 0.0 1.5e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 EFE37790.1 - 1.4e-15 57.0 0.0 1.9e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.23 EFE37790.1 - 0.00075 19.0 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I RAI16-like PF10257.4 EFE37792.1 - 3.2e-78 263.1 0.0 6.4e-78 262.1 0.0 1.5 1 1 0 1 1 1 1 Retinoic acid induced 16-like protein Lipase_3 PF01764.20 EFE37793.1 - 4.7e-19 68.3 0.0 1.1e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Zip PF02535.17 EFE37793.1 - 0.011 14.7 10.9 0.019 13.9 7.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter ILVD_EDD PF00920.16 EFE37794.1 - 1.6e-188 627.3 0.6 1.1e-187 624.5 0.4 2.0 1 1 0 1 1 1 1 Dehydratase family PEP-utilizers PF00391.18 EFE37794.1 - 0.091 12.3 0.9 2.7 7.6 0.1 2.7 2 0 0 2 2 2 0 PEP-utilising enzyme, mobile domain DUF3824 PF12868.2 EFE37794.1 - 2.3 9.1 5.2 4.6 8.1 3.6 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Pkinase PF00069.20 EFE37797.1 - 2.2e-48 164.7 0.0 3.1e-48 164.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37797.1 - 7.3e-29 100.6 0.0 1.1e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE37797.1 - 0.0026 16.7 0.0 0.0089 15.0 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Tim17 PF02466.14 EFE37799.1 - 8.8e-29 100.1 2.8 1.1e-28 99.8 1.9 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2428 PF10350.4 EFE37801.1 - 7.1e-53 179.2 0.3 1.3e-52 178.4 0.2 1.3 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 EFE37801.1 - 0.039 14.0 0.2 2 8.6 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat Herpes_UL25 PF01499.11 EFE37801.1 - 0.085 11.1 0.0 0.13 10.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family LsmAD PF06741.8 EFE37802.1 - 0.27 11.3 1.2 0.37 10.9 0.9 1.2 1 0 0 1 1 1 0 LsmAD domain DUF1191 PF06697.7 EFE37803.1 - 0.038 12.7 0.0 0.038 12.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1191) YwiC PF14256.1 EFE37803.1 - 0.078 13.0 1.9 0.41 10.7 0.1 2.1 2 0 0 2 2 2 0 YwiC-like protein DUF4381 PF14316.1 EFE37803.1 - 0.57 10.2 0.0 0.57 10.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Ctr PF04145.10 EFE37803.1 - 1.8 8.6 10.5 37 4.3 7.3 2.4 1 1 0 1 1 1 0 Ctr copper transporter family PX PF00787.19 EFE37804.1 - 4.5e-19 68.3 0.0 1.8e-18 66.3 0.0 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 EFE37804.1 - 1e-11 44.5 6.1 1.6e-05 24.2 0.2 2.1 2 0 0 2 2 2 2 Vps5 C terminal like UCH PF00443.24 EFE37805.1 - 3.8e-77 259.0 0.0 1.3e-76 257.2 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE37805.1 - 1.9e-17 63.6 0.0 1.2e-09 38.0 0.0 2.7 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 EFE37805.1 - 2.1e-14 53.7 0.0 6.6e-14 52.1 0.0 2.0 1 0 0 1 1 1 1 DUSP domain USP7_C2 PF14533.1 EFE37805.1 - 0.088 12.2 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal WTF PF03303.8 EFE37806.1 - 8e-05 22.1 1.1 0.00011 21.6 0.7 1.2 1 0 0 1 1 1 1 WTF protein DUF912 PF06024.7 EFE37806.1 - 0.002 18.1 2.0 0.002 18.1 1.4 2.3 1 1 1 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1183 PF06682.7 EFE37806.1 - 0.005 16.5 0.6 0.013 15.0 0.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1183) LRR19-TM PF15176.1 EFE37806.1 - 0.04 13.5 0.4 0.68 9.6 0.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF3753 PF12575.3 EFE37806.1 - 0.12 12.1 0.2 0.12 12.1 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) SID-1_RNA_chan PF13965.1 EFE37806.1 - 0.13 10.3 0.2 0.16 10.0 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2371 PF10177.4 EFE37806.1 - 0.15 11.9 1.5 0.29 10.9 0.1 2.0 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2371) ATP-synt_8 PF00895.15 EFE37806.1 - 0.91 9.7 0.0 0.91 9.7 0.0 3.8 4 0 0 4 4 4 0 ATP synthase protein 8 TRP PF06011.7 EFE37806.1 - 8.4 4.8 8.4 3.8 5.9 0.0 2.0 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Gtr1_RagA PF04670.7 EFE37808.1 - 7.6e-91 303.3 0.1 9.3e-91 303.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 EFE37808.1 - 6.5e-08 32.0 0.0 9.9e-08 31.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 EFE37808.1 - 2.1e-07 30.4 0.0 3.3e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE37808.1 - 6.7e-06 26.5 0.0 1.5e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFE37808.1 - 8.5e-06 25.7 0.0 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.1 EFE37808.1 - 0.0017 17.8 0.5 0.0053 16.2 0.2 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain GTP_EFTU PF00009.22 EFE37808.1 - 0.0023 17.3 0.0 0.0043 16.5 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF815 PF05673.8 EFE37808.1 - 0.012 14.5 0.1 0.021 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 EFE37808.1 - 0.013 15.7 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter NikR_C PF08753.6 EFE37808.1 - 0.054 13.3 0.2 7.2 6.5 0.0 2.6 2 0 0 2 2 2 0 NikR C terminal nickel binding domain DUF258 PF03193.11 EFE37808.1 - 0.065 12.4 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 EFE37808.1 - 0.12 11.7 0.2 0.31 10.4 0.1 1.6 1 1 0 1 1 1 0 AAA-like domain AIG1 PF04548.11 EFE37808.1 - 0.28 10.2 1.0 0.41 9.7 0.3 1.8 2 1 0 2 2 2 0 AIG1 family G-alpha PF00503.15 EFE37808.1 - 0.58 8.7 3.4 1.8 7.1 1.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit AA_permease PF00324.16 EFE37809.1 - 1.7e-119 399.2 44.4 2.4e-119 398.7 30.8 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE37809.1 - 3.9e-32 111.3 45.8 4.9e-32 110.9 31.7 1.1 1 0 0 1 1 1 1 Amino acid permease RdRP PF05183.7 EFE37811.1 - 2.8e-130 435.7 0.0 3.5e-130 435.4 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF2457 PF10446.4 EFE37811.1 - 0.055 12.1 0.2 0.079 11.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Opi1 PF08618.5 EFE37812.1 - 5.3e-90 302.3 6.8 2.8e-53 181.3 3.1 3.5 2 1 2 4 4 4 3 Transcription factor Opi1 bZIP_1 PF00170.16 EFE37813.1 - 5.6e-06 26.2 5.1 1.1e-05 25.2 3.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor Tropomyosin_1 PF12718.2 EFE37813.1 - 0.037 13.8 0.1 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 Tropomyosin like Nucleoplasmin PF03066.10 EFE37816.1 - 0.0038 16.7 0.7 0.0052 16.3 0.5 1.2 1 0 0 1 1 1 1 Nucleoplasmin Cwf_Cwc_15 PF04889.7 EFE37816.1 - 0.048 13.3 1.1 0.067 12.8 0.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4611 PF15387.1 EFE37816.1 - 0.36 11.0 4.1 0.64 10.1 2.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF2457 PF10446.4 EFE37816.1 - 0.67 8.6 13.4 1 7.9 9.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.6 EFE37816.1 - 5.7 6.7 5.9 10 5.9 4.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal AIM24 PF01987.12 EFE37817.1 - 6e-48 163.1 0.7 6.8e-48 162.9 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 eIF-5_eIF-2B PF01873.12 EFE37818.1 - 2.5e-27 95.0 0.0 4.4e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 DUF2413 PF10310.4 EFE37818.1 - 2.2 7.0 12.2 3 6.5 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) MIT PF04212.13 EFE37820.1 - 2.7e-08 33.5 0.6 6.1e-08 32.4 0.4 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain PAT1 PF09770.4 EFE37820.1 - 0.7 8.0 5.5 1.2 7.3 3.8 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PC4 PF02229.11 EFE37821.1 - 6.5e-20 70.1 0.1 1.1e-19 69.4 0.1 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) Hydantoinase_B PF02538.9 EFE37822.1 - 1.7e-203 676.6 0.0 2.6e-203 676.0 0.0 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EFE37822.1 - 1.8e-94 316.1 0.4 3.1e-94 315.3 0.3 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EFE37822.1 - 2.1e-48 164.1 0.7 8.7e-47 158.8 0.0 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region DUF3237 PF11578.3 EFE37822.1 - 0.039 13.2 0.1 0.22 10.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3237) HSBP1 PF06825.7 EFE37822.1 - 0.17 11.4 0.0 0.38 10.3 0.0 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 CH PF00307.26 EFE37823.1 - 1.4e-62 208.4 0.0 3.1e-19 68.9 0.2 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.1 EFE37823.1 - 3.2e-07 30.3 1.0 2.1e-05 24.5 0.2 2.9 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.3 EFE37823.1 - 4.1e-05 23.1 0.0 2.7 7.7 0.0 4.2 4 0 0 4 4 4 2 CAMSAP CH domain EF-hand_1 PF00036.27 EFE37823.1 - 6.4e-05 21.9 1.3 0.18 11.1 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 EFE37823.1 - 0.00044 19.9 0.9 0.019 14.8 0.1 3.0 2 0 0 2 2 2 1 EF-hand domain AhpC-TSA PF00578.16 EFE37824.1 - 1.2e-13 50.7 0.0 2.2e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EFE37824.1 - 0.001 18.6 0.0 0.0022 17.5 0.0 1.5 2 0 0 2 2 2 1 Redoxin AhpC-TSA_2 PF13911.1 EFE37824.1 - 0.0038 17.1 0.1 0.0061 16.4 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme BLVR PF06375.6 EFE37824.1 - 0.015 15.1 6.4 0.02 14.7 4.4 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) SR-25 PF10500.4 EFE37824.1 - 0.068 12.6 8.2 0.092 12.2 5.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.5 EFE37824.1 - 0.33 10.7 6.4 0.5 10.1 4.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal APH PF01636.18 EFE37825.1 - 4e-14 52.9 0.0 7.9e-14 51.9 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUP PF00674.13 EFE37825.1 - 0.073 13.0 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 DUP family EcKinase PF02958.15 EFE37825.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase Peptidase_M16_C PF05193.16 EFE37826.1 - 1.3e-34 119.4 0.3 2.9e-23 82.5 0.0 3.7 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFE37826.1 - 1.1e-32 112.8 1.6 1.8e-21 76.4 0.3 4.0 4 0 0 4 4 4 2 Insulinase (Peptidase family M16) MFS_1 PF07690.11 EFE37829.1 - 5.7e-34 117.3 37.6 7.1e-34 117.0 26.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37830.1 - 1.5e-123 412.6 26.1 2.2e-123 412.1 18.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE37830.1 - 2.2e-21 75.9 38.3 7.8e-16 57.7 13.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFE37830.1 - 0.011 13.9 7.2 0.021 13.0 1.1 2.1 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) TPR_19 PF14559.1 EFE37830.1 - 0.037 14.3 0.1 0.082 13.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3408 PF11888.3 EFE37830.1 - 0.11 12.4 6.9 0.8 9.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Hist_deacetyl PF00850.14 EFE37831.1 - 4.3e-41 141.2 0.0 6.5e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.4 EFE37831.1 - 4.1e-35 120.8 0.2 8.3e-35 119.8 0.1 1.5 1 0 0 1 1 1 1 Arb2 domain Ribosomal_L13 PF00572.13 EFE37831.1 - 0.015 15.3 0.9 0.031 14.3 0.2 1.7 2 0 0 2 2 2 0 Ribosomal protein L13 WzyE PF06899.6 EFE37831.1 - 0.06 12.0 0.0 0.1 11.2 0.0 1.3 1 0 0 1 1 1 0 WzyE protein Malic_M PF03949.10 EFE37831.1 - 0.071 12.6 0.1 1.8 8.0 0.0 2.1 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain Hist_deacetyl PF00850.14 EFE37832.1 - 3.5e-36 125.0 1.1 3.3e-35 121.8 0.0 2.1 1 1 1 2 2 2 2 Histone deacetylase domain Gp_dh_C PF02800.15 EFE37833.1 - 3.9e-74 247.3 0.0 6.2e-74 246.6 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 EFE37833.1 - 1.5e-41 141.8 0.4 7.5e-41 139.6 0.1 2.0 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.21 EFE37833.1 - 0.023 14.2 0.0 0.089 12.3 0.0 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase F-box-like PF12937.2 EFE37834.1 - 4.8e-07 29.4 1.8 4.9e-07 29.3 0.0 2.0 2 0 0 2 2 2 1 F-box-like MBOAT PF03062.14 EFE37834.1 - 0.033 13.3 0.1 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family Pho88 PF10032.4 EFE37835.1 - 1.7e-71 239.4 0.6 1.9e-71 239.2 0.4 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) DUF2576 PF10845.3 EFE37835.1 - 0.052 12.7 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Histone PF00125.19 EFE37836.1 - 1.3e-21 76.5 0.1 1.6e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFE37836.1 - 0.00043 20.2 0.0 0.00061 19.8 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HSF_DNA-bind PF00447.12 EFE37837.1 - 6.9e-30 103.2 0.3 1.5e-29 102.1 0.2 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding TMF_DNA_bd PF12329.3 EFE37837.1 - 0.028 14.2 1.9 0.11 12.3 0.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Ets PF00178.17 EFE37837.1 - 0.18 11.9 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 Ets-domain R3H PF01424.17 EFE37839.1 - 3.4e-10 39.4 0.0 7.6e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 R3H domain RRM_6 PF14259.1 EFE37839.1 - 1.2e-06 28.3 0.0 2.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE37839.1 - 1.8e-05 24.2 0.1 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE37839.1 - 0.027 14.3 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.16 EFE37840.1 - 4.4e-37 127.6 0.0 9.4e-37 126.6 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MDFI PF15316.1 EFE37840.1 - 2.7 7.9 6.0 3.9 7.4 3.1 2.0 1 1 0 1 1 1 0 MyoD family inhibitor His_Phos_2 PF00328.17 EFE37841.1 - 1.3e-14 54.3 0.0 8.5e-13 48.3 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Peptidase_M19 PF01244.16 EFE37842.1 - 1e-106 356.5 0.0 1.2e-106 356.3 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Rep_fac_C PF08542.6 EFE37843.1 - 5.8e-15 55.0 0.0 1.4e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.24 EFE37843.1 - 8.8e-15 55.0 0.4 3.1e-14 53.3 0.0 2.1 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 EFE37843.1 - 5.7e-14 52.1 0.0 1.2e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 EFE37843.1 - 1.8e-10 40.1 0.0 4.8e-08 32.1 0.0 2.3 1 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 EFE37843.1 - 1.8e-07 31.3 0.1 1e-06 28.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain DNA_pol3_delta PF06144.8 EFE37843.1 - 1.2e-06 28.1 0.3 4.1e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_19 PF13245.1 EFE37843.1 - 1.5e-06 27.8 0.0 4e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 EFE37843.1 - 2e-06 27.9 0.3 3.4e-05 23.9 0.0 2.7 2 2 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EFE37843.1 - 2.7e-06 27.1 0.0 1e-05 25.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EFE37843.1 - 3.2e-06 26.1 0.0 0.0086 14.8 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus RuvB_N PF05496.7 EFE37843.1 - 4.2e-06 25.9 0.1 6.7e-05 22.0 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 EFE37843.1 - 2.4e-05 24.0 0.3 0.00011 21.8 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 EFE37843.1 - 7.4e-05 22.4 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EFE37843.1 - 8.7e-05 21.5 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DEAD PF00270.24 EFE37843.1 - 0.00052 19.5 0.0 0.0023 17.4 0.0 2.0 2 1 0 2 2 1 1 DEAD/DEAH box helicase Mg_chelatase PF01078.16 EFE37843.1 - 0.00059 19.0 0.1 0.0017 17.5 0.0 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EFE37843.1 - 0.00082 18.9 0.0 0.0067 16.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 EFE37843.1 - 0.00091 18.2 0.0 0.0014 17.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 EFE37843.1 - 0.0022 17.9 0.0 0.012 15.4 0.0 2.3 1 1 1 2 2 1 1 AAA domain PhoH PF02562.11 EFE37843.1 - 0.0023 17.1 0.0 0.58 9.3 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein FtsK_SpoIIIE PF01580.13 EFE37843.1 - 0.005 16.3 0.0 0.28 10.6 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 EFE37843.1 - 0.0075 15.7 0.2 3.2 7.1 0.0 2.4 1 1 1 2 2 2 2 AAA-like domain AAA_25 PF13481.1 EFE37843.1 - 0.0075 15.6 0.3 0.028 13.8 0.0 2.2 3 1 0 3 3 2 1 AAA domain AAA_24 PF13479.1 EFE37843.1 - 0.008 15.7 0.4 0.018 14.6 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFE37843.1 - 0.0098 16.1 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 EFE37843.1 - 0.015 15.1 0.0 0.29 10.9 0.0 2.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_28 PF13521.1 EFE37843.1 - 0.019 14.8 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EFE37843.1 - 0.027 13.8 0.0 0.45 9.9 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_17 PF13207.1 EFE37843.1 - 0.028 15.2 0.0 0.059 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain TAFII28 PF04719.9 EFE37843.1 - 0.032 14.0 0.0 0.078 12.7 0.0 1.6 1 0 0 1 1 1 0 hTAFII28-like protein conserved region RNA_helicase PF00910.17 EFE37843.1 - 0.05 13.7 0.0 0.17 12.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.21 EFE37843.1 - 0.08 12.4 0.0 3 7.2 0.0 2.5 3 0 0 3 3 2 0 Sigma-54 interaction domain SNF2_N PF00176.18 EFE37843.1 - 0.083 11.6 0.0 0.66 8.7 0.0 2.0 1 1 0 1 1 1 0 SNF2 family N-terminal domain MiaE PF06175.6 EFE37843.1 - 0.099 12.0 0.1 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) Arch_ATPase PF01637.13 EFE37843.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase P21-Arc PF04062.9 EFE37844.1 - 1.3e-53 181.3 0.0 1.6e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit NAD_binding_10 PF13460.1 EFE37845.1 - 7e-16 58.7 0.2 1.2e-15 57.9 0.1 1.4 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFE37845.1 - 7.1e-16 58.1 0.1 2e-15 56.7 0.1 1.8 2 1 0 2 2 2 1 NmrA-like family DapB_N PF01113.15 EFE37845.1 - 8.9e-08 32.0 0.2 1.9e-07 31.0 0.2 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.19 EFE37845.1 - 4.9e-07 30.0 0.1 8.6e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 EFE37845.1 - 8.5e-07 28.2 0.1 1.1e-06 27.9 0.1 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 EFE37845.1 - 1.7e-05 23.6 0.2 2.5e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFE37845.1 - 1.9e-05 24.1 0.1 2.9e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 EFE37845.1 - 0.0007 19.5 1.0 0.0015 18.5 0.7 1.5 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_4 PF07993.7 EFE37845.1 - 0.0015 17.5 0.0 0.0023 16.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 EFE37845.1 - 0.0034 16.3 0.1 0.0049 15.7 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EFE37845.1 - 0.0061 16.4 0.1 0.0095 15.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE37845.1 - 0.011 15.3 0.1 0.018 14.7 0.1 1.3 1 0 0 1 1 1 0 KR domain GFO_IDH_MocA PF01408.17 EFE37845.1 - 0.021 15.3 0.3 0.041 14.4 0.2 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ldh_1_N PF00056.18 EFE37845.1 - 0.036 13.8 0.4 0.063 13.1 0.3 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 EFE37845.1 - 0.037 12.9 0.2 0.058 12.2 0.2 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Pkinase PF00069.20 EFE37846.1 - 1.2e-18 67.2 0.0 3.5e-18 65.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37846.1 - 1.4e-06 27.6 0.0 0.0094 15.0 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 EFE37846.1 - 0.00065 19.5 0.0 0.035 13.8 0.1 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family APH PF01636.18 EFE37847.1 - 2.6e-12 46.9 0.0 8.1e-12 45.3 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE37847.1 - 0.014 14.4 0.0 2.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M35 PF02102.10 EFE37848.1 - 1.4e-46 158.7 8.0 1.6e-46 158.6 5.6 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family DUF2393 PF09624.5 EFE37848.1 - 0.063 12.8 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) Peptidase_M35 PF02102.10 EFE37849.1 - 2.2e-41 141.7 4.5 2.5e-41 141.5 3.2 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.1 EFE37849.1 - 4.5e-05 23.9 0.1 4.8e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase DUF544 PF04424.8 EFE37850.1 - 2.2e-10 40.3 0.0 3.8e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF544) Gcd10p PF04189.8 EFE37851.1 - 3.5e-92 308.7 0.0 4.4e-92 308.4 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family CorA PF01544.13 EFE37854.1 - 0.0012 17.9 1.2 0.0021 17.1 0.6 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein NmrA PF05368.8 EFE37855.1 - 3.9e-44 150.6 1.7 1.5e-27 96.4 0.8 2.1 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.1 EFE37855.1 - 4.7e-10 39.7 0.3 2.9e-09 37.1 0.3 2.0 1 1 1 2 2 2 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFE37855.1 - 0.00049 18.9 0.0 0.00068 18.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AIG1 PF04548.11 EFE37855.1 - 0.013 14.6 0.1 0.023 13.7 0.1 1.4 1 0 0 1 1 1 0 AIG1 family TrkA_N PF02254.13 EFE37855.1 - 0.019 14.9 0.1 0.029 14.3 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain Saccharop_dh PF03435.13 EFE37855.1 - 0.028 13.4 0.1 0.034 13.1 0.1 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase Guanylate_kin PF00625.16 EFE37855.1 - 0.1 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase Epimerase PF01370.16 EFE37855.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Myb_DNA-binding PF00249.26 EFE37856.1 - 3.3e-16 59.0 0.0 3.2e-09 36.6 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE37856.1 - 9e-06 25.7 0.0 0.025 14.7 0.0 3.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain Bd3614_N PF14442.1 EFE37857.1 - 0.058 13.3 1.1 0.062 13.2 0.8 1.1 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Abhydrolase_6 PF12697.2 EFE37859.1 - 1.8e-07 31.2 0.1 5e-06 26.5 0.1 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE37859.1 - 2.2e-06 27.4 0.0 6.9e-06 25.8 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFE37859.1 - 0.0069 15.6 0.0 0.0069 15.6 0.0 2.2 3 0 0 3 3 3 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.13 EFE37859.1 - 0.0074 15.7 0.0 0.023 14.1 0.0 1.8 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.3 EFE37859.1 - 0.012 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase Abhydrolase_1 PF00561.15 EFE37859.1 - 0.13 11.8 0.1 8.8 5.8 0.0 2.6 3 0 0 3 3 3 0 alpha/beta hydrolase fold TMF_TATA_bd PF12325.3 EFE37860.1 - 5.5e-05 22.8 4.3 5.5e-05 22.8 3.0 3.3 3 2 1 4 4 4 1 TATA element modulatory factor 1 TATA binding Reo_sigmaC PF04582.7 EFE37860.1 - 0.0068 15.6 0.5 0.015 14.5 0.1 1.6 2 0 0 2 2 2 1 Reovirus sigma C capsid protein Med4 PF10018.4 EFE37860.1 - 0.01 15.2 2.0 0.01 15.2 1.4 2.8 2 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Snf7 PF03357.16 EFE37860.1 - 0.061 12.7 10.3 0.29 10.5 0.1 2.8 2 1 1 3 3 3 0 Snf7 DUF465 PF04325.8 EFE37860.1 - 0.12 12.1 3.9 1.8 8.3 1.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF465) COG2 PF06148.6 EFE37860.1 - 0.13 12.0 9.7 0.24 11.2 1.5 3.1 2 2 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF812 PF05667.6 EFE37860.1 - 0.16 10.4 11.8 0.26 9.7 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF2730 PF10805.3 EFE37860.1 - 0.18 11.5 5.1 0.051 13.3 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF1515 PF07439.6 EFE37860.1 - 0.25 11.1 5.0 0.19 11.5 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) SlyX PF04102.7 EFE37860.1 - 0.55 10.6 5.9 0.15 12.4 0.7 2.7 2 1 1 3 3 2 0 SlyX Mnd1 PF03962.10 EFE37860.1 - 0.68 9.5 12.2 0.067 12.8 1.9 2.6 2 1 0 2 2 2 0 Mnd1 family ING PF12998.2 EFE37860.1 - 0.75 10.0 8.6 2.8 8.2 2.7 2.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding SPX PF03105.14 EFE37860.1 - 0.8 9.4 7.9 0.76 9.5 2.9 2.0 2 0 0 2 2 2 0 SPX domain TPR_MLP1_2 PF07926.7 EFE37860.1 - 0.95 9.2 14.5 0.051 13.3 1.6 3.4 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein Syntaxin-6_N PF09177.6 EFE37860.1 - 1 9.8 9.3 7.4 7.0 1.3 2.9 2 2 0 2 2 2 0 Syntaxin 6, N-terminal CENP-F_leu_zip PF10473.4 EFE37860.1 - 1 9.2 20.5 0.038 13.8 4.2 3.2 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.17 EFE37860.1 - 1.1 9.2 9.5 0.89 9.6 2.3 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Nup54 PF13874.1 EFE37860.1 - 1.1 8.8 7.0 0.52 9.9 0.6 2.9 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 Allexi_40kDa PF05549.6 EFE37860.1 - 1.7 7.8 6.7 0.6 9.3 1.1 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein Mod_r PF07200.8 EFE37860.1 - 3.6 7.5 11.5 0.18 11.7 2.8 2.5 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2959 PF11172.3 EFE37860.1 - 3.9 7.1 10.3 9.9 5.8 2.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2959) Fib_alpha PF08702.5 EFE37860.1 - 4.8 7.2 6.4 1.5 8.9 0.6 2.5 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.4 EFE37860.1 - 7.3 6.8 9.1 5 7.3 1.0 2.8 2 2 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 EFE37860.1 - 8.1 5.9 22.7 0.1 12.1 4.7 2.9 2 1 0 2 2 2 0 IncA protein DivIC PF04977.10 EFE37860.1 - 8.3 5.9 7.0 0.66 9.5 0.8 2.3 3 0 0 3 3 2 0 Septum formation initiator TBPIP PF07106.8 EFE37860.1 - 9.2 5.7 12.9 0.64 9.5 3.2 2.6 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PC_rep PF01851.17 EFE37861.1 - 1.1e-35 119.7 21.5 2.4e-09 36.8 0.0 9.9 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EFE37861.1 - 2.7e-19 69.2 0.5 8.8e-14 51.5 0.0 3.9 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 EFE37861.1 - 1.4e-09 38.1 0.3 5.7e-06 26.6 0.0 4.3 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.17 EFE37861.1 - 2.3e-08 33.4 0.1 1.2 9.4 0.0 5.2 5 0 0 5 5 5 3 HEAT repeat HEAT_PBS PF03130.11 EFE37861.1 - 0.0064 16.8 2.3 0.9 10.1 0.0 4.0 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat UBN_AB PF14075.1 EFE37861.1 - 0.015 14.9 2.0 0.038 13.6 1.4 1.6 1 0 0 1 1 1 0 Ubinuclein conserved middle domain IncA PF04156.9 EFE37861.1 - 1.4 8.4 5.2 6.8 6.2 2.7 2.5 2 0 0 2 2 2 0 IncA protein Acyl-CoA_dh_1 PF00441.19 EFE37862.1 - 2.9e-40 137.7 0.3 4.7e-40 137.1 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFE37862.1 - 7.1e-20 70.2 0.1 1.2e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 EFE37862.1 - 7.9e-18 65.0 0.0 1.8e-17 63.9 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Cyt-b5 PF00173.23 EFE37862.1 - 4e-15 55.3 0.4 7.5e-15 54.4 0.3 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_2 PF08028.6 EFE37862.1 - 2.4e-07 31.0 0.1 4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain CTD PF12815.2 EFE37863.1 - 9.1e-24 84.2 46.3 7.4e-23 81.2 20.3 3.6 2 1 1 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5-NGN PF03439.8 EFE37863.1 - 1.4e-23 82.4 0.0 2.7e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.3 EFE37863.1 - 2.2e-17 63.4 11.2 2.2e-17 63.4 7.8 3.6 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.24 EFE37863.1 - 2.1e-10 39.8 12.7 0.0027 17.3 0.0 5.0 5 0 0 5 5 5 3 KOW motif DUF1506 PF07405.6 EFE37863.1 - 0.091 12.7 0.1 0.95 9.4 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1506) CS PF04969.11 EFE37864.1 - 1.1e-15 57.9 0.0 2.2e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 CS domain DUF4404 PF14357.1 EFE37864.1 - 0.75 10.2 4.3 0.51 10.7 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) GET2 PF08690.5 EFE37864.1 - 4.7 6.3 8.3 0.037 13.2 0.4 1.4 2 0 0 2 2 2 0 GET complex subunit GET2 Anoctamin PF04547.7 EFE37865.1 - 2.4e-114 382.4 9.6 2.9e-114 382.1 6.6 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Pex2_Pex12 PF04757.9 EFE37865.1 - 0.002 17.5 0.0 0.0071 15.7 0.0 1.9 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region DUF3671 PF12420.3 EFE37865.1 - 8.2 6.4 7.5 21 5.1 0.0 3.2 2 1 0 2 2 2 0 Protein of unknown function APH PF01636.18 EFE37866.1 - 7.2e-05 22.6 0.0 7.2e-05 22.6 0.0 2.8 3 1 0 4 4 4 1 Phosphotransferase enzyme family HSDR_N_2 PF13588.1 EFE37866.1 - 0.00016 21.4 0.0 0.53 10.1 0.0 2.5 2 0 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) Choline_kinase PF01633.15 EFE37866.1 - 0.00044 19.8 0.0 0.00098 18.7 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Ribosomal_60s PF00428.14 EFE37866.1 - 0.014 15.7 5.1 0.014 15.7 3.6 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Chorion_2 PF03964.10 EFE37866.1 - 0.035 14.6 3.5 0.12 12.8 2.4 2.0 1 0 0 1 1 1 0 Chorion family 2 Bap31 PF05529.7 EFE37866.1 - 0.41 10.0 8.6 0.77 9.1 6.0 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like bZIP_1 PF00170.16 EFE37867.1 - 4.9e-07 29.5 9.2 2.4e-06 27.4 6.4 2.0 1 1 0 1 1 1 1 bZIP transcription factor HALZ PF02183.13 EFE37867.1 - 0.02 14.5 0.3 0.038 13.6 0.2 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF501 PF04417.7 EFE37867.1 - 0.025 14.4 0.4 0.07 12.9 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF501) bZIP_2 PF07716.10 EFE37867.1 - 0.27 11.1 10.4 9.7 6.1 7.2 3.0 2 1 0 2 2 2 0 Basic region leucine zipper Actin PF00022.14 EFE37868.1 - 5.7e-55 186.3 0.0 1.7e-31 109.0 0.0 2.1 2 0 0 2 2 2 2 Actin YL1_C PF08265.6 EFE37869.1 - 2.8e-17 61.9 0.2 4.8e-17 61.1 0.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Pol_alpha_B_N PF08418.5 EFE37869.1 - 0.077 12.5 2.5 0.093 12.2 1.7 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Sec63 PF02889.11 EFE37872.1 - 9.1e-143 475.1 0.0 1.1e-91 307.3 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 EFE37872.1 - 4.3e-55 185.7 1.1 2.5e-28 98.6 1.1 3.1 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.10 EFE37872.1 - 9.3e-17 61.4 0.0 7.9e-08 32.3 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EFE37872.1 - 3.2e-15 55.7 0.0 3e-07 30.1 0.0 2.9 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 EFE37872.1 - 2.2e-07 31.1 1.7 0.011 15.9 0.0 3.4 3 1 0 3 3 3 2 AAA domain SNF2_N PF00176.18 EFE37872.1 - 0.00033 19.5 0.6 0.22 10.2 0.1 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain AAA_19 PF13245.1 EFE37872.1 - 0.00055 19.6 0.1 1 9.1 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain PhoH PF02562.11 EFE37872.1 - 0.0015 17.7 0.0 0.44 9.7 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein FtsK_SpoIIIE PF01580.13 EFE37872.1 - 0.0019 17.7 0.5 0.027 13.9 0.2 2.7 2 1 0 2 2 2 1 FtsK/SpoIIIE family IstB_IS21 PF01695.12 EFE37872.1 - 0.013 14.9 0.0 5 6.4 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_10 PF12846.2 EFE37872.1 - 0.022 14.1 0.0 6.1 6.1 0.0 3.8 3 1 0 4 4 4 0 AAA-like domain Longin PF13774.1 EFE37873.1 - 2.2e-14 52.7 0.0 3.3e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 EFE37873.1 - 4.8e-14 51.7 0.2 7e-14 51.1 0.1 1.2 1 0 0 1 1 1 1 Synaptobrevin Tbf5 PF06331.7 EFE37873.1 - 0.012 15.3 0.4 0.029 14.1 0.3 1.6 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 DUF2475 PF10629.4 EFE37875.1 - 0.026 14.7 0.2 0.086 13.1 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2475) KAT11 PF08214.6 EFE37875.1 - 0.057 12.4 0.7 0.066 12.2 0.5 1.1 1 0 0 1 1 1 0 Histone acetylation protein Pkinase PF00069.20 EFE37876.1 - 2.1e-25 89.3 0.0 8.4e-25 87.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37876.1 - 4.7e-06 25.8 0.0 0.0031 16.6 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase MFS_1 PF07690.11 EFE37877.1 - 7.3e-12 44.6 14.5 7.3e-12 44.6 10.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 EFE37877.1 - 0.001 19.0 4.0 0.35 10.9 0.0 3.0 3 1 0 3 3 3 2 Protein of unknown function (DUF1228) Ras PF00071.17 EFE37879.1 - 1.7e-34 118.5 0.0 1.1e-32 112.6 0.0 2.2 2 1 0 2 2 2 1 Ras family Miro PF08477.8 EFE37879.1 - 2e-15 57.3 0.0 4e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE37879.1 - 3.9e-10 39.2 0.0 6e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.1 EFE37879.1 - 0.002 18.1 0.1 0.02 14.8 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFE37879.1 - 0.0042 17.2 0.0 0.0085 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.7 EFE37879.1 - 0.0055 15.8 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFE37879.1 - 0.0063 16.4 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 EFE37879.1 - 0.026 13.7 0.0 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 EFE37879.1 - 0.04 13.4 0.0 0.53 9.7 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 EFE37879.1 - 0.05 13.2 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.1 EFE37879.1 - 0.064 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 EFE37879.1 - 0.067 12.3 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 EFE37879.1 - 0.16 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFE37879.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFE37879.1 - 0.2 11.3 0.0 0.32 10.6 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase FMN_dh PF01070.13 EFE37880.1 - 7.3e-121 403.3 0.2 8.4e-121 403.1 0.2 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 EFE37880.1 - 1.4e-05 24.2 0.1 2.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 EFE37880.1 - 1.9e-05 23.9 0.4 3.1e-05 23.3 0.1 1.4 2 0 0 2 2 2 1 Nitronate monooxygenase IMPDH PF00478.20 EFE37880.1 - 0.0023 16.8 2.2 0.0039 16.1 0.1 2.3 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.16 EFE37880.1 - 0.0065 15.7 0.0 0.75 9.0 0.0 2.2 2 0 0 2 2 2 2 Histidine biosynthesis protein Pkinase PF00069.20 EFE37881.1 - 6e-40 137.0 0.0 7.3e-25 87.5 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37881.1 - 5.5e-13 48.5 0.0 1.3e-09 37.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Bud13 PF09736.4 EFE37882.1 - 1.7e-45 154.8 0.8 1.7e-45 154.8 0.6 3.0 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex MRP-S31 PF15433.1 EFE37882.1 - 9.6 5.5 12.1 17 4.7 8.4 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 PEP-utilisers_N PF05524.8 EFE37883.1 - 0.0072 16.1 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, N-terminal HAUS5 PF14817.1 EFE37883.1 - 0.017 13.6 0.5 0.022 13.3 0.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 DUF812 PF05667.6 EFE37883.1 - 0.022 13.2 0.0 0.027 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FlaC_arch PF05377.6 EFE37883.1 - 0.043 13.7 0.9 0.099 12.5 0.6 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF1192 PF06698.6 EFE37883.1 - 0.056 13.2 2.1 0.18 11.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Bap31 PF05529.7 EFE37883.1 - 0.072 12.5 0.5 0.097 12.1 0.3 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Fungal_trans_2 PF11951.3 EFE37886.1 - 1.3e-96 323.5 1.3 1.5e-96 323.3 0.9 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Brr6_like_C_C PF10104.4 EFE37887.1 - 2.6e-44 150.0 0.5 3.4e-44 149.6 0.3 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Ninjurin PF04923.7 EFE37887.1 - 0.073 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Ninjurin Nucleo_P87 PF07267.6 EFE37887.1 - 0.41 9.2 5.4 0.6 8.7 3.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AA_permease PF00324.16 EFE37888.1 - 1.3e-40 139.1 10.9 1.5e-40 138.9 7.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE37888.1 - 4e-06 25.6 18.1 2.7e-05 22.8 12.6 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE37889.1 - 1e-14 53.7 9.8 1.2e-14 53.5 6.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE37889.1 - 0.11 11.0 10.9 0.13 10.8 7.6 1.0 1 0 0 1 1 1 0 Amino acid permease AA_permease_2 PF13520.1 EFE37890.1 - 7.8e-30 103.7 27.7 1.4e-27 96.3 18.2 2.6 1 1 1 2 2 2 1 Amino acid permease DUF3040 PF11239.3 EFE37890.1 - 7.5 6.6 13.3 0.55 10.3 0.2 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) ADH_zinc_N_2 PF13602.1 EFE37891.1 - 0.0018 19.1 0.0 0.0031 18.4 0.0 1.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFE37891.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GAD PF02938.9 EFE37891.1 - 0.032 14.3 0.1 0.038 14.1 0.0 1.1 1 0 0 1 1 1 0 GAD domain Transposase_22 PF02994.9 EFE37891.1 - 0.11 10.9 0.0 0.12 10.8 0.0 1.0 1 0 0 1 1 1 0 L1 transposable element ADH_zinc_N PF00107.21 EFE37892.1 - 2e-14 53.2 0.0 3e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE37892.1 - 1.9e-05 24.3 0.0 4.2e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.1 EFE37892.1 - 0.025 14.5 0.3 0.044 13.7 0.1 1.5 2 0 0 2 2 2 0 NADH(P)-binding AlaDh_PNT_C PF01262.16 EFE37892.1 - 0.17 11.4 0.4 0.33 10.5 0.3 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain APH PF01636.18 EFE37893.1 - 1.4e-11 44.6 0.0 5.3e-06 26.3 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family GYF PF02213.11 EFE37895.1 - 1.5e-15 56.5 1.3 2.5e-15 55.7 0.1 2.2 2 0 0 2 2 2 1 GYF domain LMBR1 PF04791.11 EFE37895.1 - 0.74 8.3 3.4 1.2 7.6 2.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Aminotran_5 PF00266.14 EFE37896.1 - 7.7e-21 74.2 0.0 1.1e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EFE37896.1 - 0.00014 20.9 0.0 0.0002 20.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EFE37896.1 - 0.0044 15.3 0.0 0.0067 14.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme zf-RING_2 PF13639.1 EFE37897.1 - 7.2e-14 51.3 8.7 1.1e-13 50.7 6.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFE37897.1 - 9e-10 38.0 4.8 1.3e-09 37.5 3.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFE37897.1 - 9.3e-08 32.0 4.9 1.7e-07 31.2 3.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EFE37897.1 - 2.9e-07 30.3 7.7 4.6e-07 29.7 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE37897.1 - 5.3e-07 29.1 8.5 8.4e-07 28.5 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE37897.1 - 8.7e-07 28.5 6.2 1.3e-06 27.9 4.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 EFE37897.1 - 0.00029 20.5 2.8 0.00056 19.6 1.9 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_RING PF05883.6 EFE37897.1 - 0.0064 16.3 1.3 0.011 15.5 0.9 1.3 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain zf-RING_4 PF14570.1 EFE37897.1 - 0.062 12.8 4.7 0.11 12.0 3.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 EFE37897.1 - 0.064 12.9 5.8 0.16 11.7 4.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger PHD PF00628.24 EFE37897.1 - 0.12 12.0 7.7 0.22 11.2 5.4 1.4 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.2 EFE37897.1 - 0.24 11.4 9.6 0.46 10.5 6.7 1.5 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 EFE37897.1 - 0.47 10.4 7.3 2.3 8.2 5.1 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 EFE37897.1 - 1.5 8.7 6.0 3.1 7.7 4.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Fis1_TPR_C PF14853.1 EFE37898.1 - 1.3e-25 88.9 0.3 2.1e-25 88.3 0.2 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 EFE37898.1 - 1.7e-12 46.4 0.1 8.8e-08 31.3 0.0 2.3 2 0 0 2 2 2 2 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.12 EFE37898.1 - 0.00099 18.8 1.6 0.0021 17.8 1.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE37898.1 - 0.023 15.3 0.1 0.048 14.3 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFE37898.1 - 0.11 12.1 2.3 0.23 11.1 1.6 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Spc24 PF08286.6 EFE37899.1 - 3.2e-41 139.7 3.0 7.8e-40 135.2 0.1 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Streptin-Immun PF11083.3 EFE37899.1 - 0.0031 17.4 2.8 0.007 16.3 0.3 2.1 1 1 1 2 2 2 1 Lantibiotic streptin immunity protein V_ATPase_I PF01496.14 EFE37899.1 - 0.0042 15.0 3.2 0.0049 14.8 2.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family APG6 PF04111.7 EFE37899.1 - 0.0091 15.0 5.9 0.012 14.6 4.1 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 MAP65_ASE1 PF03999.7 EFE37899.1 - 0.0098 14.5 4.6 0.013 14.1 3.2 1.2 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) WXG100 PF06013.7 EFE37899.1 - 0.014 15.3 2.6 0.1 12.5 0.1 2.5 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Prefoldin_2 PF01920.15 EFE37899.1 - 0.057 13.1 7.3 0.37 10.5 0.8 2.3 2 0 0 2 2 2 0 Prefoldin subunit FlaC_arch PF05377.6 EFE37899.1 - 0.088 12.7 2.8 2.3 8.1 0.1 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FlxA PF14282.1 EFE37899.1 - 0.12 12.3 3.5 6.6 6.7 0.1 2.2 2 0 0 2 2 2 0 FlxA-like protein Syntaxin PF00804.20 EFE37899.1 - 0.18 11.9 9.2 0.12 12.6 3.7 2.1 1 1 1 2 2 2 0 Syntaxin DUF342 PF03961.8 EFE37899.1 - 0.19 10.0 2.5 0.23 9.8 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Viral_P18 PF04521.8 EFE37899.1 - 0.2 11.0 7.9 0.34 10.3 0.6 2.3 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DASH_Dad3 PF08656.5 EFE37899.1 - 0.26 11.0 4.0 2.1 8.1 0.9 2.5 2 1 0 2 2 2 0 DASH complex subunit Dad3 BLOC1_2 PF10046.4 EFE37899.1 - 0.55 10.4 3.6 1.9 8.6 2.0 2.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.7 EFE37899.1 - 0.56 9.9 5.4 1.3 8.8 3.7 1.6 1 1 0 1 1 1 0 Laminin Domain II DUF972 PF06156.8 EFE37899.1 - 0.86 9.9 5.9 5.1 7.5 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Occludin_ELL PF07303.8 EFE37899.1 - 1.1 9.9 3.5 7.5 7.3 1.9 2.2 1 1 1 2 2 2 0 Occludin homology domain TMF_DNA_bd PF12329.3 EFE37899.1 - 1.2 8.9 10.6 0.68 9.7 2.0 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF607 PF04678.8 EFE37899.1 - 1.2 8.9 7.3 3.1 7.6 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF607 TBPIP PF07106.8 EFE37899.1 - 1.7 8.1 6.8 1.3 8.5 1.4 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4140 PF13600.1 EFE37899.1 - 2.7 8.4 10.3 6.9 7.1 1.6 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3847 PF12958.2 EFE37899.1 - 3.1 7.6 8.3 3.7 7.3 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Ribosomal_L29 PF00831.18 EFE37899.1 - 3.2 7.5 7.8 10 5.8 0.6 2.5 2 0 0 2 2 2 0 Ribosomal L29 protein EAP30 PF04157.11 EFE37899.1 - 3.9 6.5 7.8 3.8 6.6 2.2 2.0 1 1 1 2 2 2 0 EAP30/Vps36 family Mnd1 PF03962.10 EFE37899.1 - 5.4 6.6 8.2 17 5.0 5.7 1.7 1 1 0 1 1 1 0 Mnd1 family SlyX PF04102.7 EFE37899.1 - 5.4 7.4 6.6 14 6.1 0.4 2.6 2 1 0 2 2 2 0 SlyX DUF4200 PF13863.1 EFE37899.1 - 5.9 6.8 11.1 44 4.0 6.8 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF3431 PF11913.3 EFE37900.1 - 9.8e-61 205.0 0.0 2.9e-59 200.2 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) Med21 PF11221.3 EFE37901.1 - 1.5e-49 167.6 24.1 1.3e-48 164.5 16.7 1.9 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Spore_III_AB PF09548.5 EFE37901.1 - 0.0038 16.9 1.4 0.0042 16.8 0.1 1.6 2 0 0 2 2 2 1 Stage III sporulation protein AB (spore_III_AB) PAT1 PF09770.4 EFE37901.1 - 0.018 13.3 20.0 0.021 13.1 13.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1319 PF07028.6 EFE37901.1 - 0.032 14.4 0.4 0.072 13.2 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) TFIIA PF03153.8 EFE37901.1 - 0.43 10.4 13.2 0.54 10.1 9.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF605 PF04652.11 EFE37901.1 - 0.48 9.7 11.6 0.6 9.4 8.0 1.2 1 0 0 1 1 1 0 Vta1 like RBD-FIP PF09457.5 EFE37901.1 - 0.59 9.9 4.8 0.25 11.1 1.2 2.1 2 0 0 2 2 2 0 FIP domain ATG16 PF08614.6 EFE37901.1 - 1.5 8.6 11.4 3.2 7.5 7.9 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.1 EFE37901.1 - 4.8 6.0 9.2 6.4 5.6 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Striatin PF08232.7 EFE37901.1 - 6.8 7.0 11.0 7.8 6.8 0.4 2.3 2 0 0 2 2 2 0 Striatin family SNF2_N PF00176.18 EFE37902.1 - 2.9e-63 213.4 0.0 4.2e-63 212.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE37902.1 - 1.5e-08 34.3 0.2 6.6e-08 32.3 0.0 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF896 PF05979.7 EFE37902.1 - 0.71 9.5 8.1 10 5.8 2.9 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) zf-RING_5 PF14634.1 EFE37902.1 - 1.8 8.3 4.3 3.5 7.4 3.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain PI3_PI4_kinase PF00454.22 EFE37903.1 - 3e-39 134.8 0.0 4.6e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PDZ_2 PF13180.1 EFE37905.1 - 4.7e-06 26.3 0.1 6.6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 EFE37905.1 - 2.7e-05 24.2 0.1 3.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Ras PF00071.17 EFE37906.1 - 1.9e-49 167.1 0.0 2.3e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE37906.1 - 2.4e-15 57.0 0.0 5.2e-15 55.9 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EFE37906.1 - 4.8e-11 42.1 0.0 7.1e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.17 EFE37906.1 - 0.00022 21.3 0.1 0.0012 18.9 0.0 2.0 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.7 EFE37906.1 - 0.00094 18.3 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 EFE37906.1 - 0.004 15.8 0.8 0.79 8.3 0.0 2.9 2 1 1 3 3 3 1 G-protein alpha subunit Pox_A32 PF04665.7 EFE37906.1 - 0.027 13.7 0.1 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_33 PF13671.1 EFE37906.1 - 0.075 12.9 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFE37906.1 - 0.079 13.1 0.2 0.31 11.1 0.1 1.8 1 1 0 2 2 2 0 AAA domain UPF0079 PF02367.12 EFE37906.1 - 0.14 11.7 0.0 0.34 10.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Pkinase PF00069.20 EFE37907.1 - 3.8e-13 49.1 0.0 9.2e-13 47.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37907.1 - 1.7e-10 40.4 0.0 2.4e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 EFE37907.1 - 6.2e-05 22.6 0.1 0.00012 21.6 0.1 1.4 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 EFE37907.1 - 0.013 15.1 0.1 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Atg14 PF10186.4 EFE37909.1 - 1.1e-88 297.1 0.0 1.3e-88 296.9 0.0 1.0 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 BBP1_C PF15272.1 EFE37909.1 - 0.14 11.6 2.6 0.21 11.1 1.8 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal DASH_Spc34 PF08657.5 EFE37909.1 - 0.2 11.2 2.5 0.34 10.5 1.7 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 Prefoldin_2 PF01920.15 EFE37909.1 - 0.29 10.9 1.6 1.9 8.2 0.2 2.2 2 0 0 2 2 2 0 Prefoldin subunit Mnd1 PF03962.10 EFE37909.1 - 0.61 9.7 4.6 0.96 9.0 3.2 1.2 1 0 0 1 1 1 0 Mnd1 family LMBR1 PF04791.11 EFE37911.1 - 2e-11 43.1 19.0 5.8e-11 41.6 10.2 2.6 1 1 1 2 2 2 1 LMBR1-like membrane protein DUF4013 PF13197.1 EFE37911.1 - 0.0091 15.3 6.1 0.0091 15.3 4.2 4.3 4 1 1 5 5 5 2 Protein of unknown function (DUF4013) DUF2040 PF09745.4 EFE37911.1 - 0.24 11.1 0.5 0.96 9.2 0.1 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) GHL12 PF14882.1 EFE37912.1 - 0.058 13.4 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 12 zf-MYND PF01753.13 EFE37913.1 - 4e-11 42.5 9.3 9.8e-11 41.3 6.5 1.7 1 0 0 1 1 1 1 MYND finger PIG-F PF06699.6 EFE37915.1 - 3.7e-37 128.1 2.8 4.6e-37 127.8 2.0 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Amidase PF01425.16 EFE37916.1 - 3.7e-80 269.9 0.0 4.9e-80 269.5 0.0 1.1 1 0 0 1 1 1 1 Amidase ADH_zinc_N PF00107.21 EFE37917.1 - 3.9e-17 62.0 0.1 7e-17 61.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE37917.1 - 2e-13 50.0 0.4 7.2e-13 48.2 0.3 2.1 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Pkinase PF00069.20 EFE37918.1 - 4.2e-24 85.1 0.0 1.7e-23 83.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37918.1 - 7e-07 28.5 0.0 0.013 14.5 0.0 2.3 2 1 0 2 2 2 2 Protein tyrosine kinase RD3 PF14473.1 EFE37919.1 - 0.14 11.6 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 RD3 protein APH PF01636.18 EFE37921.1 - 1.3e-08 34.8 0.0 5.4e-08 32.8 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Methyltransf_PK PF05891.7 EFE37923.1 - 7.8e-08 31.8 0.0 8.2e-08 31.8 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase WD40 PF00400.27 EFE37924.1 - 4.1e-152 489.3 75.0 5.2e-14 51.5 0.6 13.9 13 0 0 13 13 13 13 WD domain, G-beta repeat Nup160 PF11715.3 EFE37924.1 - 8.3e-21 73.7 32.5 0.033 12.3 0.1 11.8 5 3 7 12 12 12 9 Nucleoporin Nup120/160 Ank_2 PF12796.2 EFE37924.1 - 7.3e-20 71.1 0.0 7.4e-08 32.6 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) NACHT PF05729.7 EFE37924.1 - 1.8e-19 70.0 0.0 3.3e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Ank PF00023.25 EFE37924.1 - 4.6e-12 45.0 0.1 3.4e-05 23.4 0.0 4.8 4 1 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 EFE37924.1 - 4.6e-09 35.6 0.1 0.025 14.7 0.0 4.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 EFE37924.1 - 1.3e-08 34.8 0.0 0.00015 21.8 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE37924.1 - 8e-08 32.6 0.0 0.064 13.7 0.0 4.0 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Cytochrom_D1 PF02239.11 EFE37924.1 - 1.1e-05 23.9 8.7 0.028 12.7 0.4 4.2 3 2 0 3 3 3 2 Cytochrome D1 heme domain HPS3_N PF14761.1 EFE37924.1 - 0.0009 18.6 0.0 5.2 6.4 0.0 3.6 4 0 0 4 4 4 1 Hermansky-Pudlak syndrome 3 AAA_16 PF13191.1 EFE37924.1 - 0.0019 18.2 0.0 0.006 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 EFE37924.1 - 0.0036 17.0 0.0 0.0098 15.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain DUF3447 PF11929.3 EFE37924.1 - 0.45 10.3 4.0 1.3e+02 2.4 0.0 5.8 6 2 2 8 8 8 0 Domain of unknown function (DUF3447) RhoGAP PF00620.22 EFE37928.1 - 1.9e-38 131.4 0.0 2.9e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Amidase PF01425.16 EFE37929.1 - 3.6e-80 269.9 0.8 3.2e-78 263.5 0.1 2.2 2 0 0 2 2 2 2 Amidase NAD_binding_5 PF07994.7 EFE37931.1 - 7.6e-113 376.8 0.3 9.7e-113 376.5 0.2 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 EFE37931.1 - 1.9e-45 153.2 1.5 2.3e-45 152.9 0.4 1.7 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase Ribonucleas_3_3 PF14622.1 EFE37933.1 - 1.2e-06 28.5 0.0 1.7e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 EFE37933.1 - 2.4e-05 24.7 0.0 0.00014 22.2 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease III domain Peptidase_S10 PF00450.17 EFE37935.1 - 7.5e-72 242.7 0.3 1e-71 242.2 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase LIM PF00412.17 EFE37936.1 - 1e-17 63.9 16.4 1.1e-11 44.5 2.3 3.2 3 1 0 3 3 3 2 LIM domain Glyco_hydro_3 PF00933.16 EFE37937.1 - 1.9e-40 138.7 0.0 2.4e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain 7TMR-DISM_7TM PF07695.6 EFE37938.1 - 0.28 10.8 24.1 0.35 10.4 8.9 2.2 2 0 0 2 2 2 0 7TM diverse intracellular signalling COesterase PF00135.23 EFE37939.1 - 9.4e-70 235.8 0.0 3.7e-61 207.4 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE37939.1 - 1.4e-11 44.3 0.0 2.2e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE37939.1 - 0.0054 16.4 0.0 0.0098 15.6 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Cu_amine_oxid PF01179.15 EFE37941.1 - 8.8e-171 568.1 0.3 1e-170 567.9 0.2 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.11 EFE37941.1 - 5.7e-08 32.7 0.0 1.1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.11 EFE37941.1 - 0.00014 21.8 0.1 0.0003 20.7 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain AMP-binding PF00501.23 EFE37942.1 - 0.014 13.8 0.0 0.016 13.6 0.0 1.2 1 1 0 1 1 1 0 AMP-binding enzyme AMP-binding PF00501.23 EFE37943.1 - 4.7e-22 77.9 0.2 7e-18 64.2 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.1 EFE37943.1 - 1.8e-08 35.2 0.0 3.2e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fungal_trans PF04082.13 EFE37944.1 - 1.6e-07 30.5 0.1 3.7e-07 29.2 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.1 EFE37945.1 - 4.2e-27 95.4 0.0 4.8e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFE37945.1 - 1.4e-16 60.9 0.1 2.3e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE37945.1 - 0.00015 21.5 0.5 0.00047 19.8 0.3 1.8 1 1 0 1 1 1 1 KR domain MFS_1 PF07690.11 EFE37948.1 - 3.3e-11 42.5 26.5 4.1e-10 38.9 11.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE37948.1 - 0.023 13.1 18.0 0.063 11.6 9.4 2.6 1 1 1 2 2 2 0 MFS/sugar transport protein Aldedh PF00171.17 EFE37950.1 - 1.3e-73 247.9 0.0 1.3e-70 238.0 0.0 2.2 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Adap_comp_sub PF00928.16 EFE37951.1 - 2.1e-53 181.1 0.0 5.4e-53 179.7 0.0 1.6 1 1 0 1 1 1 1 Adaptor complexes medium subunit family DUF4588 PF15251.1 EFE37952.1 - 5.1e-05 23.3 11.4 0.00022 21.2 7.9 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) SNF2_N PF00176.18 EFE37953.1 - 2.1e-81 273.0 0.3 3.2e-81 272.4 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 EFE37953.1 - 1.2e-44 150.8 1.2 1.2e-44 150.8 0.9 2.2 2 0 0 2 2 2 1 SLIDE HAND PF09110.6 EFE37953.1 - 4.5e-28 97.9 3.8 4.5e-28 97.9 2.6 4.1 3 0 0 3 3 3 1 HAND Helicase_C PF00271.26 EFE37953.1 - 1.2e-14 53.8 0.0 3.8e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE37953.1 - 1.6e-08 34.6 0.0 2.7e-07 30.5 0.0 3.2 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.3 EFE37953.1 - 3.3e-07 29.4 0.0 8.3e-07 28.0 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 EFE37953.1 - 5e-06 26.1 0.0 1.2e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Opi1 PF08618.5 EFE37953.1 - 0.011 14.7 0.0 0.011 14.7 0.0 2.1 2 0 0 2 2 2 0 Transcription factor Opi1 DEAD_2 PF06733.10 EFE37953.1 - 0.021 14.2 0.1 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 DEAD_2 AAA_14 PF13173.1 EFE37953.1 - 0.027 14.3 2.2 0.071 13.0 0.1 2.8 4 0 0 4 4 4 0 AAA domain SpoU_methylase PF00588.14 EFE37954.1 - 1.4e-25 89.8 0.0 2.9e-25 88.7 0.0 1.6 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 EFE37954.1 - 2.3e-07 30.9 0.0 4.3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding zf-PHD-like PF15446.1 EFE37955.1 - 1e-71 239.8 10.5 2.3e-71 238.6 7.3 1.7 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.18 EFE37955.1 - 3.2e-58 196.8 2.0 4.8e-58 196.3 1.4 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE37955.1 - 1.2e-13 50.6 0.0 4e-13 49.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EFE37955.1 - 4e-12 45.5 3.0 1.1e-11 44.1 2.1 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 EFE37955.1 - 5.2e-07 29.6 0.0 3.2e-06 27.0 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Chromo PF00385.19 EFE37955.1 - 9.5e-07 28.4 2.3 0.026 14.1 0.2 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DEAD PF00270.24 EFE37955.1 - 2.4e-05 23.9 0.0 4.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD PF00628.24 EFE37955.1 - 0.00017 21.1 3.4 0.00017 21.1 2.4 3.9 2 2 0 2 2 2 1 PHD-finger DEAD_2 PF06733.10 EFE37955.1 - 0.0042 16.5 0.0 0.012 14.9 0.0 1.8 1 0 0 1 1 1 1 DEAD_2 Na_Ca_ex PF01699.19 EFE37956.1 - 0.002 17.7 0.8 0.002 17.7 0.6 2.0 1 1 1 2 2 2 2 Sodium/calcium exchanger protein HNH_2 PF13391.1 EFE37957.1 - 7.9e-07 28.7 0.0 1.8e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease Clr5 PF14420.1 EFE37958.1 - 0.018 14.9 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 Clr5 domain MFS_1 PF07690.11 EFE37959.1 - 1.4e-11 43.7 11.4 1.5e-11 43.6 7.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE37959.1 - 0.00097 17.8 4.9 0.0012 17.4 3.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter COX4_pro PF03626.9 EFE37959.1 - 0.33 11.0 3.7 0.61 10.2 2.6 1.6 1 1 0 1 1 1 0 Prokaryotic Cytochrome C oxidase subunit IV DAO PF01266.19 EFE37960.1 - 3.1e-42 144.7 0.1 4.4e-42 144.2 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase ThiF PF00899.16 EFE37960.1 - 0.00032 20.5 0.2 0.0013 18.5 0.0 2.0 2 0 0 2 2 2 1 ThiF family NAD_binding_8 PF13450.1 EFE37960.1 - 0.0032 17.4 0.0 0.011 15.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFE37960.1 - 0.0099 15.6 0.1 0.036 13.8 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFE37960.1 - 0.023 14.5 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE37960.1 - 0.033 14.2 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFE37960.1 - 0.054 12.3 1.6 0.13 11.1 1.1 1.5 1 1 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.15 EFE37960.1 - 0.19 11.8 0.1 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TadE PF07811.7 EFE37960.1 - 1.4 8.9 4.8 0.33 10.8 0.6 2.0 2 0 0 2 2 2 0 TadE-like protein Thioredoxin PF00085.15 EFE37961.1 - 8.2e-27 92.9 0.0 6.8e-25 86.7 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.1 EFE37961.1 - 2e-12 47.3 0.0 5.6e-06 26.2 0.0 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 EFE37961.1 - 2.8e-05 24.2 0.1 0.083 13.0 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFE37961.1 - 0.00022 21.2 0.0 0.0043 17.1 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin-like HyaE PF07449.6 EFE37961.1 - 0.00025 20.9 0.0 0.28 11.0 0.0 2.8 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.1 EFE37961.1 - 0.00032 20.6 0.1 0.0051 16.8 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.1 EFE37961.1 - 0.027 14.2 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin domain ETC_C1_NDUFA5 PF04716.9 EFE37962.1 - 9.5e-23 79.4 0.9 2.6e-22 78.0 0.1 2.2 2 0 0 2 2 2 1 ETC complex I subunit conserved region Ku_PK_bind PF08785.6 EFE37962.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Ku C terminal domain like MT PF12777.2 EFE37962.1 - 0.14 10.8 0.7 0.2 10.3 0.5 1.3 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor Med9 PF07544.8 EFE37962.1 - 0.4 10.4 4.2 5.5 6.7 0.1 3.3 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Coatomer_WDAD PF04053.9 EFE37963.1 - 2.4e-154 514.4 0.0 6.5e-107 358.0 0.1 2.6 2 1 1 3 3 3 2 Coatomer WD associated region WD40 PF00400.27 EFE37963.1 - 2e-43 144.7 5.2 2e-10 40.1 0.2 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 EFE37963.1 - 0.0048 15.1 4.1 0.074 11.1 0.1 3.2 2 1 1 4 4 4 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 EFE37963.1 - 0.0054 16.4 0.0 3.3 7.5 0.0 3.2 2 1 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Pkinase PF00069.20 EFE37964.1 - 3e-65 219.9 0.0 6e-65 218.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE37964.1 - 6.3e-30 104.1 0.0 3.8e-20 72.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 EFE37964.1 - 1.1e-08 35.4 0.1 1.1e-08 35.4 0.1 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFE37964.1 - 0.066 12.1 0.0 7.8 5.3 0.0 2.2 2 0 0 2 2 2 0 Kinase-like SWIRM PF04433.12 EFE37965.1 - 1.5e-08 34.6 0.0 4e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.26 EFE37965.1 - 3.5e-08 33.3 0.0 9.3e-08 32.0 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PG_binding_1 PF01471.13 EFE37965.1 - 0.012 15.6 0.0 0.048 13.6 0.0 2.1 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Serglycin PF04360.7 EFE37966.1 - 0.14 11.8 3.3 0.34 10.6 2.3 1.6 1 0 0 1 1 1 0 Serglycin WD40 PF00400.27 EFE37967.1 - 1.4e-20 72.3 5.5 4.6e-06 26.2 0.0 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat Glycos_transf_4 PF00953.16 EFE37968.1 - 2.9e-24 85.6 7.6 2.9e-24 85.6 5.2 2.0 2 1 0 2 2 2 1 Glycosyl transferase family 4 Aconitase PF00330.15 EFE37969.1 - 7.1e-179 595.1 0.1 8.8e-179 594.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFE37969.1 - 1.5e-44 151.3 0.0 2.6e-44 150.4 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Pribosyltran PF00156.22 EFE37970.1 - 2.7e-15 56.2 0.2 5.1e-15 55.2 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PBP1_TM PF14812.1 EFE37970.1 - 0.0026 18.0 4.9 0.028 14.6 4.6 1.7 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal MTHFR PF02219.12 EFE37971.1 - 6.4e-116 386.4 0.0 9.5e-116 385.8 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1804 PF08822.6 EFE37971.1 - 0.034 13.8 0.1 0.083 12.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) DUF2418 PF10332.4 EFE37973.1 - 9.1e-35 118.9 0.3 1.7e-34 118.0 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) E1_DerP2_DerF2 PF02221.10 EFE37974.1 - 1.7e-19 70.3 0.3 4.9e-18 65.6 0.2 2.0 1 1 0 1 1 1 1 ML domain TRP_N PF14558.1 EFE37974.1 - 4.2e-05 23.5 0.0 0.00031 20.7 0.0 1.9 2 0 0 2 2 2 1 ML-like domain NOGCT PF08155.6 EFE37975.1 - 6.8e-30 102.5 1.1 1.4e-29 101.5 0.8 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.9 EFE37975.1 - 1.3e-26 92.2 0.8 2.8e-26 91.1 0.6 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.18 EFE37975.1 - 9.4e-15 54.5 0.0 2.1e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE37975.1 - 8.5e-08 31.6 0.0 3.2e-07 29.7 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 EFE37975.1 - 4.2e-05 24.0 0.0 0.00012 22.6 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Dynamin_N PF00350.18 EFE37975.1 - 0.004 16.9 0.1 1.7 8.4 0.0 2.7 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.1 EFE37975.1 - 0.055 13.4 0.2 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain Acetyltransf_1 PF00583.19 EFE37976.1 - 1.4e-08 34.5 0.0 2.4e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE37976.1 - 1.2e-07 31.7 0.0 1.9e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE37976.1 - 9.5e-05 22.0 0.0 0.00017 21.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.1 EFE37976.1 - 0.0072 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE37976.1 - 0.0091 16.1 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Nucleoplasmin PF03066.10 EFE37976.1 - 0.025 14.1 0.8 0.045 13.2 0.6 1.5 1 0 0 1 1 1 0 Nucleoplasmin Acetyltransf_8 PF13523.1 EFE37976.1 - 0.042 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE37976.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Osteopontin PF00865.13 EFE37976.1 - 0.33 10.1 11.1 0.5 9.5 7.7 1.2 1 0 0 1 1 1 0 Osteopontin PBP1_TM PF14812.1 EFE37976.1 - 0.88 9.9 5.1 1.7 9.0 3.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Asp_protease PF09668.5 EFE37977.1 - 1e-60 202.7 0.2 1.6e-60 202.1 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.18 EFE37977.1 - 7.3e-11 41.3 0.0 1.3e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Asp_protease_2 PF13650.1 EFE37977.1 - 1.1e-10 41.8 0.1 3.6e-10 40.2 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease UBA PF00627.26 EFE37977.1 - 1.4e-07 31.1 0.0 2.6e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain gag-asp_proteas PF13975.1 EFE37977.1 - 5e-06 26.2 0.0 1.3e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 EFE37977.1 - 7.4e-06 25.9 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.3 EFE37977.1 - 0.00076 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RVP PF00077.15 EFE37977.1 - 0.0012 18.7 0.0 0.0031 17.4 0.0 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.1 EFE37977.1 - 0.0036 16.8 0.0 0.007 15.8 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UN_NPL4 PF11543.3 EFE37977.1 - 0.0046 17.2 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Fungal_trans_2 PF11951.3 EFE37978.1 - 3e-18 65.6 0.9 1.4e-13 50.2 0.8 2.9 3 0 0 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE37978.1 - 3.8e-07 29.8 11.9 8.3e-07 28.8 8.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.1 EFE37980.1 - 1.1e-05 25.4 4.2 0.092 13.1 0.4 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE37980.1 - 0.0011 19.2 5.5 0.21 11.9 0.1 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type DUF2413 PF10310.4 EFE37981.1 - 0.88 8.3 7.4 0.99 8.1 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) CDC45 PF02724.9 EFE37981.1 - 4.4 5.2 24.4 4.7 5.1 16.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 EFE37981.1 - 6.5 5.1 20.4 7.8 4.8 14.2 1.0 1 0 0 1 1 1 0 Daxx Family MIP-T3 PF10243.4 EFE37981.1 - 7.3 4.9 22.9 8.4 4.7 15.9 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Not3 PF04065.10 EFE37982.1 - 1.8e-96 321.9 15.3 2.7e-96 321.3 10.6 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 EFE37982.1 - 4.5e-42 143.1 10.3 1.2e-41 141.7 7.2 1.8 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Poty_PP PF08440.5 EFE37982.1 - 0.0026 16.8 0.8 0.0053 15.8 0.6 1.4 1 0 0 1 1 1 1 Potyviridae polyprotein DUF2373 PF10180.4 EFE37982.1 - 0.017 14.6 3.7 0.039 13.4 2.6 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) Cep57_MT_bd PF06657.8 EFE37982.1 - 0.073 13.0 0.3 0.073 13.0 0.2 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Snapin_Pallidin PF14712.1 EFE37982.1 - 3.2 8.1 8.5 4.6 7.6 0.7 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Tyr_Deacylase PF02580.11 EFE37983.1 - 6.3e-38 130.0 0.1 4.4e-37 127.2 0.1 1.9 1 1 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Pro_isomerase PF00160.16 EFE37984.1 - 5.3e-31 107.9 0.1 1.1e-30 106.9 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 EFE37984.1 - 2.3e-08 33.5 9.2 0.00093 18.8 2.0 2.3 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EFE37984.1 - 4.2e-06 26.2 6.4 0.00015 21.3 1.6 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFE37984.1 - 0.00014 21.3 1.2 0.00014 21.3 0.9 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE37984.1 - 0.0043 17.6 10.1 0.19 12.4 6.4 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE37984.1 - 0.026 14.4 7.3 0.31 10.9 4.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFE37984.1 - 0.064 13.0 0.5 0.064 13.0 0.3 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE37984.1 - 0.1 13.2 5.2 0.34 11.6 1.5 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 EFE37984.1 - 0.15 11.9 3.6 0.78 9.6 0.9 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat FmdA_AmdA PF03069.10 EFE37985.1 - 4.4e-145 483.0 0.0 5e-145 482.8 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family DUF4237 PF14021.1 EFE37986.1 - 4e-30 103.9 0.0 6.3e-30 103.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4237) DUF2841 PF11001.3 EFE37988.1 - 1.5e-25 89.4 0.0 2.9e-25 88.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) CVNH PF08881.5 EFE37990.1 - 0.085 13.0 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 CVNH domain RP-C_C PF11800.3 EFE37990.1 - 1.2 8.7 6.2 2 8.0 1.9 2.4 2 0 0 2 2 2 0 Replication protein C C-terminal region Sugar_tr PF00083.19 EFE37991.1 - 1.8e-43 148.8 21.5 1.3e-28 99.7 3.4 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE37991.1 - 1.1e-23 83.4 20.9 3.9e-22 78.4 12.6 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily EI24 PF07264.6 EFE37993.1 - 0.0068 15.8 16.3 1.4 8.3 11.3 3.0 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Inp1 PF12634.2 EFE37994.1 - 6.6e-33 113.4 0.0 1.3e-32 112.4 0.0 1.5 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 SRP14 PF02290.10 EFE37995.1 - 1.5e-25 88.8 0.1 2e-25 88.5 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle 14kD protein MIF4G PF02854.14 EFE37996.1 - 1.3e-23 83.4 4.9 1.4e-22 80.1 2.8 2.4 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.12 EFE37996.1 - 2.7e-16 59.2 0.3 1.2e-15 57.1 0.0 2.4 2 0 0 2 2 2 1 MA3 domain Hydrolase_like PF13242.1 EFE37997.1 - 4.9e-05 22.9 0.0 0.0001 21.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 EFE37997.1 - 0.013 15.6 0.1 1.5 9.0 0.0 3.1 2 2 0 2 2 2 0 Haloacid dehalogenase-like hydrolase MRC1 PF09444.5 EFE37999.1 - 2e-38 132.0 18.1 2e-38 132.0 12.6 6.3 4 3 1 5 5 5 1 MRC1-like domain Bromodomain PF00439.20 EFE38000.1 - 1.5e-36 124.1 3.7 1.5e-19 69.6 0.2 2.6 2 0 0 2 2 2 2 Bromodomain BAH PF01426.13 EFE38000.1 - 6.9e-16 58.0 0.8 1.4e-15 57.1 0.6 1.5 1 0 0 1 1 1 1 BAH domain Nucleo_P87 PF07267.6 EFE38000.1 - 0.33 9.5 10.3 0.22 10.1 1.3 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Nucleoplasmin PF03066.10 EFE38000.1 - 0.44 10.0 8.9 1 8.8 6.1 1.6 1 0 0 1 1 1 0 Nucleoplasmin OTU PF02338.14 EFE38001.1 - 2e-12 47.7 0.0 3.3e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease UN_NPL4 PF11543.3 EFE38001.1 - 0.046 14.0 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 VWA_2 PF13519.1 EFE38002.1 - 4.9e-06 26.7 0.0 9.7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.16 EFE38002.1 - 0.0001 22.1 6.2 0.0001 22.1 4.3 5.5 5 1 0 5 5 5 1 IBR domain VWA PF00092.23 EFE38002.1 - 0.037 13.7 0.0 0.074 12.7 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Fungal_trans PF04082.13 EFE38003.1 - 8.9e-12 44.4 0.5 1.7e-11 43.5 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE38003.1 - 1.9e-10 40.4 10.5 3.8e-10 39.5 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_12 PF13087.1 EFE38004.1 - 5.2e-31 107.5 0.0 1e-30 106.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EFE38004.1 - 5.3e-18 65.4 0.0 3.8e-11 43.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EFE38004.1 - 3.7e-09 36.2 0.0 3.4e-08 33.1 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain UvrD-helicase PF00580.16 EFE38004.1 - 0.00043 19.6 0.0 0.0011 18.3 0.0 1.6 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.13 EFE38004.1 - 0.0014 18.1 0.1 0.63 9.5 0.0 3.1 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.1 EFE38004.1 - 0.0053 16.3 0.0 0.012 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 EFE38004.1 - 0.0097 15.7 0.0 0.14 11.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD_C PF13361.1 EFE38004.1 - 0.021 14.2 0.0 5.3 6.4 0.0 2.4 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain C2 PF00168.25 EFE38005.1 - 2.6e-12 46.3 0.0 4.5e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain UTP15_C PF09384.5 EFE38006.1 - 5.6e-50 168.8 0.0 9.3e-50 168.1 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 EFE38006.1 - 9.8e-23 79.1 6.4 6e-07 29.1 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat PQQ_2 PF13360.1 EFE38006.1 - 4.1e-05 23.1 0.5 0.0016 17.9 0.0 2.3 1 1 1 2 2 2 2 PQQ-like domain Nup160 PF11715.3 EFE38006.1 - 0.047 11.8 1.2 0.21 9.6 0.5 2.2 1 1 0 1 1 1 0 Nucleoporin Nup120/160 PhyH PF05721.8 EFE38007.1 - 8.4e-43 146.8 0.0 1e-42 146.5 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF3298 PF11738.3 EFE38007.1 - 0.075 13.5 0.1 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3298) TFIIA PF03153.8 EFE38008.1 - 0.084 12.7 1.6 0.089 12.6 1.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 EFE38008.1 - 0.67 8.1 14.0 0.69 8.0 9.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF605 PF04652.11 EFE38008.1 - 7 5.9 19.8 8 5.7 13.7 1.1 1 0 0 1 1 1 0 Vta1 like Lipase_GDSL_2 PF13472.1 EFE38010.1 - 5.6e-14 52.6 0.0 7.2e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Chitin_synth_1 PF01644.12 EFE38011.1 - 1.7e-80 268.5 0.0 2.4e-80 268.0 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EFE38011.1 - 3.4e-31 106.7 0.0 6.9e-31 105.7 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EFE38011.1 - 1.2e-21 76.7 2.3 1.3e-17 63.3 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.1 EFE38011.1 - 3.8e-08 33.4 0.0 1.9e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EFE38011.1 - 3.3e-06 26.9 13.2 3.3e-06 26.9 9.2 3.0 2 1 0 2 2 2 1 Glycosyl transferase family group 2 ABC2_membrane_2 PF12679.2 EFE38011.1 - 8.9 5.0 18.0 3.3 6.4 10.4 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein LMWPc PF01451.16 EFE38012.1 - 9.5e-22 77.8 0.0 1.1e-21 77.5 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase COQ7 PF03232.8 EFE38013.1 - 2.9e-61 205.8 0.1 3.6e-61 205.5 0.1 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.12 EFE38013.1 - 0.0061 16.8 0.0 0.012 15.9 0.0 1.6 1 1 0 1 1 1 1 Rubrerythrin DUF1817 PF08847.6 EFE38013.1 - 0.1 12.1 0.1 2.4 7.6 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1817) Ribosomal_60s PF00428.14 EFE38014.1 - 0.052 13.9 2.3 0.063 13.6 1.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein TLP-20 PF06088.6 EFE38014.1 - 0.084 12.5 0.2 0.098 12.3 0.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Plus-3 PF03126.13 EFE38015.1 - 1e-17 64.1 0.1 8.1e-12 45.1 0.0 3.2 3 1 1 4 4 4 2 Plus-3 domain Oxysterol_BP PF01237.13 EFE38016.1 - 3.5e-118 394.1 0.2 7e-118 393.1 0.0 1.6 2 0 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.1 EFE38016.1 - 1.3e-39 134.1 1.0 3.7e-39 132.6 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 EFE38016.1 - 0.00041 20.5 0.8 0.00083 19.5 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 EFE38016.1 - 0.091 13.0 7.6 0.039 14.2 1.7 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain ECR1_N PF14382.1 EFE38017.1 - 2.2e-09 36.4 0.0 4.9e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 EFE38017.1 - 0.0019 18.1 0.1 0.032 14.1 0.1 2.4 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 Dynamin_N PF00350.18 EFE38018.1 - 2.5e-32 112.0 0.1 4.9e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFE38018.1 - 1.1e-16 60.4 0.1 1.1e-15 57.2 0.1 2.2 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.18 EFE38018.1 - 1.4e-05 25.0 0.0 7.1e-05 22.7 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE38018.1 - 0.0027 18.1 0.1 0.01 16.3 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein GED PF02212.13 EFE38018.1 - 0.0045 16.8 2.4 0.045 13.6 0.3 2.8 2 0 0 2 2 2 1 Dynamin GTPase effector domain FeoB_N PF02421.13 EFE38018.1 - 0.053 12.8 0.1 4.8 6.4 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_29 PF13555.1 EFE38018.1 - 0.053 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 EFE38018.1 - 0.88 9.8 6.3 1.4 9.1 1.0 3.0 1 1 0 2 2 2 0 AAA domain FAD_binding_4 PF01565.18 EFE38019.1 - 1.2e-15 57.2 1.1 2.8e-15 56.0 0.8 1.7 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE38019.1 - 2e-10 40.3 0.1 1.2e-09 37.9 0.0 2.3 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.5 EFE38019.1 - 0.1 11.6 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Ino80_Iec3 PF14612.1 EFE38020.1 - 9e-82 274.6 6.5 1.2e-81 274.1 4.5 1.2 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling RRM_1 PF00076.17 EFE38021.1 - 2.2e-26 91.2 0.1 1.4e-14 53.4 0.0 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE38021.1 - 7.2e-24 83.5 0.0 1.9e-12 47.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE38021.1 - 2.7e-07 30.3 0.1 0.00044 20.0 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE38021.1 - 0.037 13.7 0.0 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Consortin_C PF15281.1 EFE38023.1 - 0.088 12.3 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Consortin C-terminus Btz PF09405.5 EFE38024.1 - 4.5e-22 78.4 3.3 4.5e-22 78.4 2.3 2.6 4 0 0 4 4 4 1 CASC3/Barentsz eIF4AIII binding Merozoite_SPAM PF07133.6 EFE38025.1 - 2 8.2 23.8 2 8.2 16.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CPSF100_C PF13299.1 EFE38025.1 - 5.4 7.1 11.7 5.8 7.0 8.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RNA_polI_A34 PF08208.6 EFE38025.1 - 5.9 6.5 31.2 6.8 6.3 21.6 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Rtf2 PF04641.7 EFE38025.1 - 8.9 5.4 18.5 9.7 5.3 12.8 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger E1-E2_ATPase PF00122.15 EFE38026.1 - 3.7e-52 176.6 0.3 9.6e-52 175.3 0.2 1.7 1 0 0 1 1 1 1 E1-E2 ATPase HMA PF00403.21 EFE38026.1 - 8.3e-49 163.5 0.1 3.3e-12 46.3 0.0 4.4 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.21 EFE38026.1 - 5.2e-41 141.4 0.7 1.2e-40 140.2 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFE38026.1 - 9e-13 48.8 0.0 2.9e-12 47.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE38026.1 - 7.7e-06 25.6 0.0 0.0081 15.7 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase B12-binding PF02310.14 EFE38026.1 - 0.012 15.4 0.1 11 5.8 0.0 4.6 4 1 1 5 5 5 0 B12 binding domain PCI PF01399.22 EFE38027.1 - 0.00012 22.3 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 PCI domain BLVR PF06375.6 EFE38027.1 - 0.11 12.3 13.6 0.22 11.3 9.4 1.5 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) TAF1D PF15333.1 EFE38027.1 - 0.17 11.6 12.0 0.3 10.8 8.3 1.3 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D RR_TM4-6 PF06459.7 EFE38027.1 - 0.38 10.6 10.9 0.55 10.0 7.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.12 EFE38027.1 - 7 6.3 8.2 14 5.3 5.7 1.5 1 1 0 1 1 1 0 DDHD domain Atrophin-1 PF03154.10 EFE38027.1 - 7.7 4.5 8.9 14 3.6 6.2 1.4 1 0 0 1 1 1 0 Atrophin-1 family Peptidase_S49_N PF08496.5 EFE38027.1 - 9.6 5.9 14.0 27 4.4 9.3 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RGS PF00615.14 EFE38028.1 - 1.1e-12 48.1 0.0 5.2e-09 36.2 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain Bromodomain PF00439.20 EFE38029.1 - 7.4e-26 89.8 0.8 1.4e-25 88.9 0.6 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 EFE38029.1 - 1.4e-09 38.0 0.1 2.8e-09 36.9 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE38029.1 - 4.4e-09 36.2 0.1 8.4e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Rad1 PF02144.11 EFE38030.1 - 6.7e-91 303.8 0.1 7.8e-91 303.6 0.1 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 SbcCD_C PF13558.1 EFE38031.1 - 9e-12 44.7 0.0 2.5e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.1 EFE38031.1 - 0.0045 17.3 7.3 0.0045 17.3 5.1 7.7 1 1 1 3 3 3 1 AAA domain DASH_Dam1 PF08653.5 EFE38031.1 - 2.6 7.8 10.3 2.8 7.7 0.0 5.3 5 0 0 5 5 5 0 DASH complex subunit Dam1 PPP4R2 PF09184.6 EFE38032.1 - 1.4e-07 31.3 3.6 1.4e-07 31.3 2.5 2.7 3 1 0 3 3 3 1 PPP4R2 zf-H2C2_2 PF13465.1 EFE38034.1 - 4.7e-13 48.7 7.6 1.9e-07 30.9 0.1 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EFE38034.1 - 1.4e-11 44.0 13.6 1.4e-05 25.1 1.6 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE38034.1 - 3.1e-10 39.6 14.0 3.9e-05 23.6 1.6 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE38034.1 - 9.2e-07 28.8 1.3 0.091 12.9 0.2 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFE38034.1 - 0.00013 22.0 1.9 0.011 15.9 0.3 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type Zn_ribbon_recom PF13408.1 EFE38034.1 - 0.024 14.8 0.3 0.064 13.5 0.2 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Elf1 PF05129.8 EFE38034.1 - 0.095 12.3 0.7 0.18 11.4 0.5 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-Di19 PF05605.7 EFE38034.1 - 0.11 12.6 1.9 0.22 11.6 1.3 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 EFE38034.1 - 6.6 6.7 8.2 40 4.3 0.5 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.1 EFE38034.1 - 9.7 5.9 12.0 1.7 8.3 0.4 3.2 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Pkinase PF00069.20 EFE38035.1 - 8.2e-53 179.1 0.1 4.6e-36 124.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38035.1 - 7.2e-26 90.8 0.0 1.7e-24 86.3 0.0 2.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE38035.1 - 3.9e-05 22.7 0.0 9.6e-05 21.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 EFE38035.1 - 0.00061 19.5 0.6 0.0031 17.2 0.0 2.3 3 0 0 3 3 3 1 Phosphotransferase enzyme family SH3_1 PF00018.23 EFE38037.1 - 1.8e-14 52.8 0.0 2.8e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE38037.1 - 9.9e-13 47.4 0.0 3.1e-12 45.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 EFE38037.1 - 5.2e-09 35.4 0.0 8.8e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SAS4 PF15460.1 EFE38039.1 - 5.7e-34 116.0 4.7 1.9e-33 114.3 3.3 1.9 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 CENP-B_dimeris PF09026.5 EFE38039.1 - 0.0061 16.7 14.7 0.014 15.6 10.2 1.6 1 0 0 1 1 1 1 Centromere protein B dimerisation domain RXT2_N PF08595.6 EFE38039.1 - 0.21 11.3 6.7 0.86 9.3 4.7 2.0 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.7 EFE38039.1 - 1.2 6.9 21.8 2.3 6.0 15.1 1.4 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 EFE38039.1 - 2 6.3 13.5 4 5.3 9.4 1.5 1 0 0 1 1 1 0 CDC45-like protein BTV_NS2 PF04514.7 EFE38039.1 - 3.9 6.2 10.3 9.5 4.9 7.1 1.7 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF2457 PF10446.4 EFE38039.1 - 4 6.0 31.0 0.0094 14.7 10.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) TRAP_alpha PF03896.11 EFE38039.1 - 7.1 5.5 9.9 15 4.5 6.9 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Protocadherin PF08374.6 EFE38040.1 - 0.01 15.5 3.8 0.014 15.0 2.6 1.2 1 0 0 1 1 1 0 Protocadherin NST1 PF13945.1 EFE38040.1 - 0.089 12.8 5.6 0.15 12.1 3.9 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator DARPP-32 PF05395.7 EFE38040.1 - 0.16 12.1 2.3 0.26 11.4 1.6 1.4 1 1 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 BORA_N PF15280.1 EFE38040.1 - 0.32 10.3 5.2 0.062 12.6 0.3 1.8 2 0 0 2 2 2 0 Protein aurora borealis N-terminus Mpp10 PF04006.7 EFE38040.1 - 1 7.6 7.2 1.2 7.4 5.0 1.1 1 0 0 1 1 1 0 Mpp10 protein BLVR PF06375.6 EFE38040.1 - 8.1 6.2 15.2 10 5.9 8.6 2.1 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) Brix PF04427.13 EFE38042.1 - 4.6e-29 101.4 0.0 6.2e-29 101.0 0.0 1.2 1 0 0 1 1 1 1 Brix domain SH3_9 PF14604.1 EFE38043.1 - 2.2e-32 110.3 2.9 3.9e-16 58.3 0.2 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 EFE38043.1 - 1.3e-29 101.2 4.3 1.1e-14 53.4 0.3 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.12 EFE38043.1 - 7.8e-17 60.5 0.1 3.6e-08 32.7 0.0 2.7 3 0 0 3 3 3 2 Variant SH3 domain Cofilin_ADF PF00241.15 EFE38043.1 - 3.6e-11 43.0 0.0 6.2e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dynamin_M PF01031.15 EFE38044.1 - 3.7e-114 380.4 0.0 6.3e-114 379.7 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 EFE38044.1 - 4.6e-56 189.2 0.7 2.7e-55 186.7 0.0 2.5 3 0 0 3 3 3 1 Dynamin family GED PF02212.13 EFE38044.1 - 8.7e-32 108.8 1.0 2.1e-31 107.6 0.7 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EFE38044.1 - 0.0005 20.0 0.4 0.003 17.5 0.3 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE38044.1 - 0.007 16.8 0.0 0.018 15.5 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein zf-CCHC_4 PF14392.1 EFE38044.1 - 0.15 11.7 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-C2H2 PF00096.21 EFE38045.1 - 0.0066 16.7 5.9 0.0066 16.7 4.1 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE38045.1 - 8.8 6.9 23.7 0.047 14.0 2.7 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger LisH PF08513.6 EFE38050.1 - 7.5e-05 22.3 0.1 0.00014 21.4 0.0 1.5 1 0 0 1 1 1 1 LisH TRAPP PF04051.11 EFE38051.1 - 2.7e-37 127.6 0.0 3.6e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component WD40 PF00400.27 EFE38052.1 - 2.1e-41 138.3 14.9 9.3e-08 31.6 0.3 7.2 6 1 1 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EFE38052.1 - 0.017 13.8 4.5 1.3 7.6 0.3 2.8 1 1 1 2 2 2 0 Nup133 N terminal like PQQ_2 PF13360.1 EFE38052.1 - 0.068 12.6 0.1 5.5 6.3 0.0 2.6 3 0 0 3 3 3 0 PQQ-like domain Glyco_hydro_47 PF01532.15 EFE38054.1 - 6.1e-62 209.7 0.0 7.5e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DNA_pol_B_exo2 PF10108.4 EFE38054.1 - 0.026 14.0 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB EcoRII-C PF09019.6 EFE38054.1 - 0.17 11.7 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 EcoRII C terminal Glyco_hydro_47 PF01532.15 EFE38055.1 - 2.3e-60 204.5 0.0 2.9e-60 204.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 MiaE PF06175.6 EFE38055.1 - 0.23 10.7 0.0 0.37 10.1 0.0 1.2 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) Trypan_PARP PF05887.6 EFE38056.1 - 9.5e-07 28.7 36.8 1.8e-06 27.7 25.5 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Helicase_C PF00271.26 EFE38056.1 - 1.5e-06 27.9 0.0 3.1e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFE38056.1 - 0.005 15.6 0.0 0.008 15.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.1 EFE38056.1 - 0.0098 15.5 11.8 0.022 14.4 8.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE38056.1 - 0.7 9.6 10.0 1.9 8.2 6.9 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFE38056.1 - 1.3 9.0 11.6 1.2 9.2 6.7 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE38056.1 - 3 7.5 11.7 12 5.7 8.1 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PLRV_ORF5 PF01690.12 EFE38056.1 - 6.3 5.8 21.4 11 5.0 14.8 1.4 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein TPR_11 PF13414.1 EFE38057.1 - 8.4e-11 41.3 11.2 2.1e-06 27.2 0.1 4.8 3 1 1 4 4 4 3 TPR repeat TPR_2 PF07719.12 EFE38057.1 - 8.7e-09 34.6 23.4 0.00017 21.2 0.0 6.8 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFE38057.1 - 4.1e-08 32.4 0.2 0.06 13.1 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFE38057.1 - 4.3e-08 32.4 7.5 0.00022 20.7 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFE38057.1 - 2e-07 30.8 16.9 0.15 11.9 2.0 5.6 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFE38057.1 - 2.4e-07 31.2 32.1 0.0006 20.4 0.1 6.7 6 3 1 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE38057.1 - 5.2e-06 26.6 19.5 0.12 13.0 0.1 8.7 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFE38057.1 - 1.5e-05 25.2 15.2 1.2 9.4 0.1 6.1 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFE38057.1 - 0.00033 20.2 9.9 0.75 9.7 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFE38057.1 - 0.0012 19.1 12.8 5.7 7.6 0.2 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TOM20_plant PF06552.7 EFE38057.1 - 0.072 12.6 0.0 0.22 11.1 0.0 1.8 1 0 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_17 PF13431.1 EFE38057.1 - 0.29 11.4 7.4 29 5.1 0.0 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat Pmp3 PF01679.12 EFE38058.1 - 3.3e-19 68.3 7.0 4.5e-19 67.8 4.9 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator SH3_9 PF14604.1 EFE38059.1 - 1.3e-07 31.1 0.2 2.5e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFE38059.1 - 0.0003 20.1 0.1 0.00056 19.2 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SKG6 PF08693.5 EFE38059.1 - 0.044 13.1 2.7 0.078 12.3 1.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain FixQ PF05545.6 EFE38059.1 - 0.045 13.4 0.2 1.5 8.5 0.0 2.5 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ SAYSvFN PF10260.4 EFE38059.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved domain (SAYSvFN) Syndecan PF01034.15 EFE38059.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Rax2 PF12768.2 EFE38059.1 - 0.14 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity VPEP PF07589.6 EFE38059.1 - 8 6.5 6.3 3.6 7.6 1.9 2.1 2 0 0 2 2 2 0 PEP-CTERM motif Metallophos PF00149.23 EFE38060.1 - 5.8e-09 35.6 8.0 1.8e-08 33.9 5.5 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE38060.1 - 5.7e-05 22.9 0.0 9.2e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_18 PF00704.23 EFE38061.1 - 7.8e-63 212.9 0.6 1.4e-62 212.2 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Ins_beta PF03488.9 EFE38062.1 - 0.24 11.2 1.8 0.7 9.7 1.3 1.8 1 1 0 1 1 1 0 Nematode insulin-related peptide beta type NIF PF03031.13 EFE38064.1 - 2.7e-39 134.3 0.0 4e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 EFE38064.1 - 0.073 13.2 0.4 0.28 11.4 0.0 2.1 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Fungal_trans PF04082.13 EFE38065.1 - 3.6e-20 71.9 0.0 1.4e-19 70.0 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF1344 PF07076.6 EFE38066.1 - 0.088 12.3 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) Amino_oxidase PF01593.19 EFE38066.1 - 0.1 11.6 0.0 0.38 9.7 0.0 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GATA PF00320.22 EFE38067.1 - 9e-07 28.1 1.4 1.9e-06 27.1 0.9 1.6 1 0 0 1 1 1 1 GATA zinc finger DivIVA PF05103.8 EFE38067.1 - 0.00021 21.3 2.5 0.00031 20.8 1.7 1.2 1 0 0 1 1 1 1 DivIVA protein Snapin_Pallidin PF14712.1 EFE38067.1 - 0.011 16.0 1.5 0.015 15.5 0.8 1.5 1 1 0 1 1 1 0 Snapin/Pallidin DUF1465 PF07323.7 EFE38067.1 - 0.012 15.2 2.1 0.58 9.6 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) DUF3461 PF11944.3 EFE38067.1 - 0.02 14.7 0.3 0.031 14.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) DASH_Spc19 PF08287.6 EFE38067.1 - 0.043 13.4 5.2 0.068 12.7 3.6 1.3 1 0 0 1 1 1 0 Spc19 CTD PF12815.2 EFE38067.1 - 0.045 14.1 4.7 0.074 13.4 3.3 1.3 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Pox_A_type_inc PF04508.7 EFE38067.1 - 0.074 12.8 2.0 0.59 10.0 0.2 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat IncA PF04156.9 EFE38067.1 - 0.075 12.6 6.3 0.096 12.2 4.3 1.2 1 0 0 1 1 1 0 IncA protein DUF904 PF06005.7 EFE38067.1 - 0.081 13.2 4.6 0.15 12.3 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Cwf_Cwc_15 PF04889.7 EFE38067.1 - 0.11 12.2 5.9 0.15 11.7 4.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AATF-Che1 PF13339.1 EFE38067.1 - 0.23 11.5 4.4 0.39 10.8 3.0 1.4 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF4164 PF13747.1 EFE38067.1 - 0.31 11.1 6.0 0.62 10.2 4.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) APG6 PF04111.7 EFE38067.1 - 0.48 9.4 6.2 0.64 8.9 4.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF972 PF06156.8 EFE38067.1 - 0.7 10.2 3.4 1.2 9.5 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) SlyX PF04102.7 EFE38067.1 - 1.3 9.4 4.7 2.3 8.6 3.3 1.4 1 0 0 1 1 1 0 SlyX DivIC PF04977.10 EFE38067.1 - 8.9 5.8 7.2 9.1 5.8 2.5 2.1 1 1 1 2 2 2 0 Septum formation initiator DUF2828 PF11443.3 EFE38068.1 - 0.55 8.3 5.5 0.77 7.8 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) KilA-N PF04383.8 EFE38069.1 - 0.0079 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 KilA-N domain PTCB-BRCT PF12738.2 EFE38070.1 - 0.00017 21.3 0.3 0.00045 20.0 0.0 1.9 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.21 EFE38070.1 - 0.0017 18.4 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Mg_trans_NIPA PF05653.9 EFE38071.1 - 8.3e-88 294.2 27.1 1.2e-87 293.7 18.8 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 EFE38071.1 - 1.1e-06 28.7 3.7 1.1e-06 28.7 2.5 3.1 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 EFE38071.1 - 7.2e-06 26.0 6.3 7.2e-06 26.0 4.4 3.2 3 1 1 4 4 4 1 EamA-like transporter family Patatin PF01734.17 EFE38072.1 - 1.2e-27 97.1 0.0 2.3e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase RolB_RolC PF02027.12 EFE38072.1 - 0.022 13.9 0.1 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 RolB/RolC glucosidase family DUF2235 PF09994.4 EFE38073.1 - 1.7e-90 303.1 0.0 2.1e-90 302.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) MOSC PF03473.12 EFE38074.1 - 5.9e-16 58.1 0.0 8.6e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 MOSC domain SHMT PF00464.14 EFE38075.1 - 5.4e-184 611.1 0.0 3.4e-174 578.9 0.0 2.0 2 0 0 2 2 2 2 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 EFE38075.1 - 0.075 12.1 0.0 0.17 10.9 0.0 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase MFS_1 PF07690.11 EFE38077.1 - 6.2e-35 120.5 33.0 6.2e-35 120.5 22.9 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Ras PF00071.17 EFE38078.1 - 3.2e-40 137.1 0.9 7.2e-39 132.7 0.6 2.0 1 1 0 1 1 1 1 Ras family Miro PF08477.8 EFE38078.1 - 5.1e-09 36.6 0.1 3.6e-07 30.6 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein AMP-binding PF00501.23 EFE38080.1 - 1.4e-60 204.8 0.0 1.3e-59 201.7 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE38080.1 - 4.1e-15 56.4 0.0 1.3e-14 54.8 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sushi_2 PF09014.5 EFE38081.1 - 0.024 14.4 0.1 0.036 13.8 0.1 1.3 1 0 0 1 1 1 0 Beta-2-glycoprotein-1 fifth domain SPRY PF00622.23 EFE38082.1 - 4.4e-15 55.8 0.0 9.5e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 SPRY domain Pyr_redox_2 PF07992.9 EFE38083.1 - 2.9e-37 128.4 0.4 4e-37 128.0 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 EFE38083.1 - 1.4e-30 105.4 0.1 3.1e-30 104.4 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 EFE38083.1 - 7.8e-14 51.8 0.1 7.8e-14 51.8 0.1 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE38083.1 - 0.0094 16.0 0.0 0.062 13.3 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EFE38083.1 - 0.073 12.7 0.2 0.16 11.5 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 EFE38083.1 - 1 8.1 3.1 0.83 8.4 0.2 2.2 3 1 1 4 4 4 0 Glucose inhibited division protein A ECH PF00378.15 EFE38084.1 - 4.4e-37 127.5 0.0 5.4e-37 127.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family tRNA-synt_2b PF00587.20 EFE38085.1 - 8.6e-48 162.1 0.0 1.2e-47 161.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFE38085.1 - 0.00021 21.1 0.0 0.0013 18.6 0.0 2.3 3 0 0 3 3 3 1 Anticodon binding domain Fungal_trans PF04082.13 EFE38087.1 - 1.7e-23 82.8 0.0 3.2e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_2 PF04909.9 EFE38088.1 - 5.6e-14 52.3 0.0 6.5e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.11 EFE38089.1 - 6.7e-28 97.4 30.4 1.1e-27 96.6 20.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Glycophorin_A PF01102.13 EFE38089.1 - 0.23 11.2 0.6 0.7 9.6 0.4 1.8 1 0 0 1 1 1 0 Glycophorin A Peptidase_C12 PF01088.16 EFE38092.1 - 5.8e-54 182.4 0.0 1e-53 181.6 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Fungal_trans_2 PF11951.3 EFE38093.1 - 6.9e-09 34.7 0.8 1.1e-08 34.0 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Apc5 PF12862.2 EFE38093.1 - 0.11 12.4 0.0 21 5.0 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 HEAT PF02985.17 EFE38095.1 - 1.6e-26 89.9 16.6 6.2e-05 22.7 0.0 11.6 14 0 0 14 14 13 4 HEAT repeat HEAT_EZ PF13513.1 EFE38095.1 - 2.3e-26 91.5 16.2 4.7e-13 49.1 0.0 11.0 8 3 5 14 14 14 4 HEAT-like repeat HEAT_2 PF13646.1 EFE38095.1 - 2.6e-24 85.2 2.3 3.8e-09 36.7 0.0 8.2 3 3 4 8 8 8 6 HEAT repeats CLASP_N PF12348.3 EFE38095.1 - 2.1e-09 37.0 0.2 0.0056 16.0 0.1 5.9 3 3 2 5 5 5 2 CLASP N terminal Cnd1 PF12717.2 EFE38095.1 - 3.1e-09 36.9 0.0 0.0057 16.5 0.0 5.8 4 2 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.2 EFE38095.1 - 4.7e-09 36.5 0.0 0.014 15.7 0.0 4.8 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region Xpo1 PF08389.7 EFE38095.1 - 6.1e-06 26.2 0.2 0.00036 20.4 0.0 4.0 4 1 0 4 4 3 1 Exportin 1-like protein RIX1 PF08167.7 EFE38095.1 - 1.2e-05 24.9 2.4 0.059 13.0 0.0 5.1 4 1 2 6 6 6 1 rRNA processing/ribosome biogenesis MMS19_C PF12460.3 EFE38095.1 - 2e-05 23.4 6.6 1.1 7.8 0.0 5.0 4 2 0 5 5 5 3 RNAPII transcription regulator C-terminal Arm PF00514.18 EFE38095.1 - 8.4e-05 22.2 3.7 1.7 8.5 0.0 6.5 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.15 EFE38095.1 - 0.00036 19.0 0.0 0.21 9.8 0.0 3.5 2 2 1 3 3 3 1 Adaptin N terminal region Sec7_N PF12783.2 EFE38095.1 - 0.0071 15.7 0.7 0.16 11.3 0.1 2.8 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Dopey_N PF04118.9 EFE38095.1 - 0.0095 14.7 0.0 0.029 13.1 0.0 1.8 1 0 0 1 1 1 1 Dopey, N-terminal IBN_N PF03810.14 EFE38095.1 - 0.078 12.9 1.3 2.2 8.2 0.0 3.9 3 1 0 3 3 2 0 Importin-beta N-terminal domain DNA_alkylation PF08713.6 EFE38095.1 - 0.14 11.6 0.0 2.5 7.5 0.0 2.4 2 0 0 2 2 2 0 DNA alkylation repair enzyme CDC45 PF02724.9 EFE38095.1 - 0.37 8.7 2.5 0.56 8.1 1.7 1.2 1 0 0 1 1 1 0 CDC45-like protein HEAT_PBS PF03130.11 EFE38095.1 - 0.46 11.0 6.7 21 5.9 0.0 5.6 7 1 0 7 7 5 0 PBS lyase HEAT-like repeat Syja_N PF02383.13 EFE38096.1 - 1.8e-91 306.2 0.0 2.8e-91 305.6 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.3 EFE38096.1 - 1.9e-38 130.3 0.0 3.4e-38 129.5 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase Mg_trans_NIPA PF05653.9 EFE38097.1 - 2.9e-46 157.7 5.4 3.6e-46 157.4 3.7 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA 7TMR-DISM_7TM PF07695.6 EFE38097.1 - 0.0035 17.0 3.8 0.0046 16.6 2.7 1.2 1 0 0 1 1 1 1 7TM diverse intracellular signalling DUF2142 PF09913.4 EFE38097.1 - 0.01 14.5 0.3 0.015 13.9 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) TrbC PF04956.8 EFE38097.1 - 0.03 14.3 1.3 0.044 13.7 0.9 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family EamA PF00892.15 EFE38097.1 - 0.062 13.3 5.7 0.096 12.7 3.9 1.3 1 0 0 1 1 1 0 EamA-like transporter family DUF2420 PF10336.4 EFE38098.1 - 1.1e-11 44.2 0.0 2e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Clat_adaptor_s PF01217.15 EFE38099.1 - 5.2e-07 29.4 1.1 8e-07 28.8 0.6 1.3 1 1 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.6 EFE38099.1 - 0.0028 17.7 0.4 0.0048 17.0 0.2 1.5 1 1 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) Pox_MCEL PF03291.11 EFE38099.1 - 0.03 13.2 0.2 0.037 12.9 0.1 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Adap_comp_sub PF00928.16 EFE38100.1 - 2.6e-19 69.3 0.0 3.1e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family FTR1 PF03239.9 EFE38102.1 - 6.9e-81 271.5 11.6 8.6e-81 271.2 8.0 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF3169 PF11368.3 EFE38102.1 - 0.007 15.6 0.4 0.007 15.6 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3169) DUF4231 PF14015.1 EFE38102.1 - 0.0086 16.0 0.3 0.0086 16.0 0.2 2.7 4 0 0 4 4 4 1 Protein of unknown function (DUF4231) DUF2206 PF09971.4 EFE38102.1 - 0.06 12.1 1.7 0.15 10.8 0.4 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) Cu-oxidase_2 PF07731.9 EFE38103.1 - 8.9e-45 151.5 8.7 5.7e-41 139.2 0.4 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 EFE38103.1 - 3.2e-42 142.9 3.3 3.3e-39 133.2 0.3 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EFE38103.1 - 1.1e-37 129.3 1.3 2.1e-33 115.4 0.4 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.1 EFE38103.1 - 0.00017 21.3 0.0 3.8 7.4 0.0 3.4 2 1 0 2 2 2 2 Cupredoxin-like domain OMPdecase PF00215.19 EFE38104.1 - 1.7e-08 34.1 0.0 4.7e-07 29.4 0.0 2.4 2 1 0 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family Cyt-b5 PF00173.23 EFE38105.1 - 2.2e-19 69.0 0.3 3.4e-18 65.2 0.0 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 EFE38105.1 - 7.8e-08 32.7 20.9 1.7e-07 31.6 12.4 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.8 EFE38105.1 - 0.026 14.5 0.4 0.049 13.6 0.3 1.4 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region PMI_typeI PF01238.16 EFE38106.1 - 1.4e-122 409.2 0.1 1.5e-95 320.3 0.0 2.1 1 1 1 2 2 2 2 Phosphomannose isomerase type I AraC_binding PF02311.14 EFE38106.1 - 0.022 14.4 0.0 3.4 7.3 0.0 2.6 2 0 0 2 2 2 0 AraC-like ligand binding domain DUF1325 PF07039.6 EFE38108.1 - 7.5e-30 103.2 0.0 1.7e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.5 EFE38108.1 - 0.092 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Tom22 PF04281.8 EFE38108.1 - 7.6 6.0 9.3 0.29 10.6 1.8 2.1 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 GTP_cyclohydro2 PF00925.15 EFE38109.1 - 1.1e-56 190.6 0.0 1.9e-51 173.6 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II Methyltransf_23 PF13489.1 EFE38110.1 - 2.2e-13 50.2 0.0 2.9e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38110.1 - 4.9e-11 42.4 0.0 8e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38110.1 - 3.3e-09 37.1 0.0 9.3e-09 35.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38110.1 - 3.5e-09 37.0 0.0 1.2e-08 35.3 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38110.1 - 6.4e-08 33.1 0.0 2.2e-07 31.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38110.1 - 1.4e-05 25.3 0.0 3.9e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE38110.1 - 0.0014 17.7 0.0 0.0058 15.7 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.1 EFE38110.1 - 0.024 15.4 0.0 0.057 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_19 PF04672.7 EFE38110.1 - 0.032 13.4 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl methyltransferase DREV PF05219.7 EFE38110.1 - 0.14 10.9 0.0 0.41 9.4 0.0 1.8 2 0 0 2 2 2 0 DREV methyltransferase Fungal_trans PF04082.13 EFE38111.1 - 6e-10 38.4 0.1 1.2e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.17 EFE38112.1 - 3.2e-43 147.9 0.0 3.8e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Trypsin_2 PF13365.1 EFE38114.1 - 1.2e-05 25.2 0.0 2.7e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.6 EFE38114.1 - 0.00036 19.0 0.0 0.02 13.2 0.0 2.1 2 0 0 2 2 2 2 Peptidase family S64 Peptidase_S32 PF05579.8 EFE38114.1 - 0.018 13.9 0.0 0.033 13.1 0.0 1.4 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 DUF955 PF06114.8 EFE38114.1 - 0.057 13.1 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF955) DUF155 PF02582.9 EFE38116.1 - 7.3e-52 175.7 0.2 1.2e-51 175.1 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DUF445 PF04286.7 EFE38119.1 - 0.002 17.7 6.0 0.0033 17.0 4.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF445) TINF2_N PF14973.1 EFE38119.1 - 0.63 10.1 5.2 0.18 11.9 0.2 2.1 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus DUF4101 PF13355.1 EFE38119.1 - 0.69 10.3 5.3 1.3 9.4 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4101) THP2 PF09432.5 EFE38119.1 - 0.83 9.5 4.5 0.38 10.6 0.2 2.3 1 1 1 2 2 2 0 Tho complex subunit THP2 Syntaxin_2 PF14523.1 EFE38119.1 - 2.6 8.1 7.4 1.9 8.5 2.3 2.3 2 0 0 2 2 2 0 Syntaxin-like protein Ribosomal_L7Ae PF01248.21 EFE38120.1 - 2.9e-26 90.8 0.9 3.8e-26 90.4 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ank_2 PF12796.2 EFE38121.1 - 1.9e-27 95.4 0.3 4.1e-18 65.4 0.2 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFE38121.1 - 2e-24 85.0 0.6 1.5e-10 40.9 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 EFE38121.1 - 3.8e-22 76.9 0.4 2e-07 30.4 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 EFE38121.1 - 1.8e-16 58.5 0.0 7.9e-06 25.6 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 EFE38121.1 - 9.4e-15 54.6 0.1 5.2e-08 33.1 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Steroid_dh PF02544.11 EFE38123.1 - 5.1e-11 42.5 1.5 5.1e-11 42.5 1.0 2.3 2 1 1 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase Podoplanin PF05808.6 EFE38124.1 - 0.006 16.1 2.7 0.01 15.4 1.8 1.3 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.5 EFE38124.1 - 0.017 14.4 0.8 0.017 14.4 0.6 1.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Rax2 PF12768.2 EFE38124.1 - 0.19 10.9 0.7 0.51 9.4 0.5 1.7 1 1 0 1 1 1 0 Cortical protein marker for cell polarity Rotamase_3 PF13616.1 EFE38125.1 - 1.1e-17 64.4 0.2 1.3e-17 64.1 0.1 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.16 EFE38125.1 - 1.7e-15 57.4 0.0 2.4e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 EFE38125.1 - 4.5e-05 24.0 0.0 6.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain UAA PF08449.6 EFE38126.1 - 1.1e-70 238.0 10.1 3.2e-70 236.4 7.0 1.6 1 1 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.10 EFE38126.1 - 2e-07 30.3 0.2 0.0023 17.0 0.0 2.3 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.15 EFE38126.1 - 8.1e-05 22.6 37.9 8.9e-05 22.5 6.9 3.8 4 1 0 4 4 4 2 EamA-like transporter family EmrE PF13536.1 EFE38126.1 - 0.0023 18.1 7.7 0.0023 18.1 5.4 3.0 3 1 0 3 3 3 2 Multidrug resistance efflux transporter TPT PF03151.11 EFE38126.1 - 1.2 8.8 23.5 0.19 11.3 7.3 3.2 2 2 0 2 2 2 0 Triose-phosphate Transporter family Sen15 PF09631.5 EFE38127.1 - 8.8e-17 61.1 0.0 4.2e-16 59.0 0.0 1.9 1 1 0 1 1 1 1 Sen15 protein PH PF00169.24 EFE38128.1 - 6e-07 29.6 0.0 1.5e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 PH domain GRAM PF02893.15 EFE38128.1 - 0.00046 19.6 0.0 0.0011 18.4 0.0 1.5 1 0 0 1 1 1 1 GRAM domain PH_11 PF15413.1 EFE38128.1 - 0.0045 17.2 1.5 2.3 8.4 0.1 3.1 3 0 0 3 3 3 2 Pleckstrin homology domain Kri1 PF05178.7 EFE38129.1 - 1.7e-27 95.6 26.6 1.7e-27 95.6 18.5 5.9 5 3 0 5 5 5 1 KRI1-like family Kri1_C PF12936.2 EFE38129.1 - 3.1e-27 94.3 3.6 3.1e-27 94.3 2.5 4.5 3 2 2 5 5 5 1 KRI1-like family C-terminal FTZ PF03867.9 EFE38129.1 - 0.041 13.1 3.3 0.068 12.4 2.3 1.3 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Rod_C PF10493.4 EFE38129.1 - 0.069 11.4 0.1 0.11 10.7 0.1 1.2 1 0 0 1 1 1 0 Rough deal protein C-terminal region Mito_carr PF00153.22 EFE38130.1 - 2.2e-66 219.5 5.6 2.5e-23 81.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF605 PF04652.11 EFE38131.1 - 3 7.1 29.9 4.6 6.5 20.7 1.4 1 0 0 1 1 1 0 Vta1 like Stb3 PF10330.4 EFE38133.1 - 6.9e-35 118.6 0.0 1.4e-34 117.6 0.0 1.5 1 0 0 1 1 1 1 Putative Sin3 binding protein Ribosomal_60s PF00428.14 EFE38133.1 - 2.5 8.5 8.2 10 6.5 0.0 3.4 4 0 0 4 4 4 0 60s Acidic ribosomal protein p450 PF00067.17 EFE38134.1 - 4.3e-43 147.4 0.0 6.4e-41 140.3 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Voldacs PF03517.8 EFE38135.1 - 0.047 13.5 0.0 0.055 13.3 0.0 1.1 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling APH PF01636.18 EFE38136.1 - 1.7e-14 54.1 0.0 7.7e-14 51.9 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF2305 PF10230.4 EFE38136.1 - 0.032 13.6 0.0 0.048 13.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) DUF1679 PF07914.6 EFE38136.1 - 0.11 11.1 0.1 0.29 9.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) PTS_2-RNA PF01885.11 EFE38137.1 - 2e-47 160.9 0.0 2.4e-47 160.6 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Rad4 PF03835.10 EFE38138.1 - 1.7e-36 124.7 0.0 3.4e-36 123.8 0.0 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 EFE38138.1 - 6.3e-29 99.5 0.0 4.4e-28 96.8 0.0 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 EFE38138.1 - 1.3e-19 69.4 0.1 2.7e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 EFE38138.1 - 7.9e-15 54.9 1.8 9.1e-15 54.7 0.2 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 EFE38138.1 - 0.0026 17.9 0.0 0.0089 16.2 0.0 2.0 2 0 0 2 2 2 1 Transglutaminase-like superfamily SapC PF07277.6 EFE38138.1 - 0.047 13.0 0.0 0.09 12.0 0.0 1.4 1 0 0 1 1 1 0 SapC Filament PF00038.16 EFE38140.1 - 1.5e-06 27.9 162.2 0.0061 16.0 35.2 4.8 1 1 3 4 4 4 4 Intermediate filament protein CENP-F_leu_zip PF10473.4 EFE38140.1 - 7e-05 22.6 24.8 7e-05 22.6 17.2 9.0 2 1 7 10 10 10 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.1 EFE38140.1 - 0.00044 18.8 42.2 0.00044 18.8 29.3 6.2 1 1 6 7 7 7 5 AAA domain DUF3584 PF12128.3 EFE38140.1 - 0.0013 16.2 42.1 0.0013 16.2 29.2 5.3 1 1 4 5 5 5 4 Protein of unknown function (DUF3584) Myosin_tail_1 PF01576.14 EFE38140.1 - 0.47 8.1 190.9 0.028 12.1 33.7 3.4 1 1 2 3 3 3 0 Myosin tail PTPA PF03095.10 EFE38142.1 - 5.3e-106 354.1 0.0 7.4e-106 353.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF572 PF04502.8 EFE38143.1 - 5.6e-43 147.3 5.8 1.8e-42 145.7 4.0 1.7 1 1 0 1 1 1 1 Family of unknown function (DUF572) Glyco_hydro_3_C PF01915.17 EFE38144.1 - 6.1e-55 186.2 0.2 2.6e-54 184.1 0.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFE38144.1 - 2.6e-18 65.7 0.1 5e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.16 EFE38144.1 - 0.0028 16.6 0.0 0.0043 16.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3 PF00933.16 EFE38145.1 - 1.3e-62 211.4 0.0 1.9e-62 210.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain PNP_UDP_1 PF01048.15 EFE38146.1 - 2.8e-36 124.6 0.0 3.4e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily DUF2757 PF10955.3 EFE38146.1 - 0.032 14.4 0.1 0.073 13.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) BUD22 PF09073.5 EFE38147.1 - 2.3e-92 310.3 17.8 3.1e-92 309.9 12.4 1.1 1 0 0 1 1 1 1 BUD22 SIS PF01380.17 EFE38148.1 - 4.6e-12 45.6 0.0 1.6e-11 43.8 0.0 2.0 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.1 EFE38148.1 - 1.8e-05 24.4 0.0 3.8e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 SIS domain CheX PF13690.1 EFE38148.1 - 0.21 11.4 1.4 5.7 6.8 0.1 2.7 3 0 0 3 3 3 0 Chemotaxis phosphatase CheX Ubie_methyltran PF01209.13 EFE38149.1 - 3.5e-78 261.9 0.0 5.6e-78 261.2 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFE38149.1 - 2.7e-14 53.0 0.0 3.2e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38149.1 - 9.4e-13 48.4 0.0 1.7e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38149.1 - 4.9e-10 39.7 0.0 7.6e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38149.1 - 2.1e-09 37.3 0.0 3.3e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38149.1 - 3.6e-09 36.8 0.0 7.6e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38149.1 - 1e-08 35.7 0.0 1.7e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE38149.1 - 0.00011 22.2 0.0 0.00024 21.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFE38149.1 - 0.047 13.3 0.0 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 Hypothetical methyltransferase Sororin PF09666.5 EFE38149.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Sororin protein E1_dh PF00676.15 EFE38150.1 - 2.3e-90 302.3 0.3 2.8e-90 302.1 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 EFE38150.1 - 0.00033 20.2 0.1 0.0014 18.2 0.1 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Transketolase_N PF00456.16 EFE38150.1 - 0.00034 19.5 1.5 0.00081 18.2 0.0 1.8 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.1 EFE38150.1 - 0.0078 15.1 0.0 0.024 13.6 0.0 1.6 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase XFP_N PF09364.5 EFE38150.1 - 0.042 12.4 0.0 0.12 10.9 0.0 1.7 2 0 0 2 2 2 0 XFP N-terminal domain DUF217 PF02697.9 EFE38150.1 - 0.077 13.2 1.4 10 6.4 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized ACR, COG1753 RRM_1 PF00076.17 EFE38152.1 - 0.00011 21.8 0.0 0.00027 20.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_4 PF14570.1 EFE38152.1 - 0.014 14.9 0.1 0.024 14.2 0.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RRM_5 PF13893.1 EFE38152.1 - 0.017 14.9 0.0 0.047 13.5 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cyclin PF08613.6 EFE38153.1 - 1e-15 58.4 0.3 2.2e-15 57.3 0.2 1.6 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EFE38153.1 - 0.0019 17.7 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain ACC_epsilon PF13822.1 EFE38154.1 - 3 8.2 6.1 1 9.7 2.3 1.7 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit YihI PF04220.7 EFE38154.1 - 3.4 6.9 10.0 4.1 6.6 6.7 1.3 1 1 0 1 1 1 0 Der GTPase activator (YihI) GHMP_kinases_N PF00288.21 EFE38155.1 - 7.3e-14 51.5 0.0 1.6e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EFE38155.1 - 0.00024 21.2 0.0 0.0005 20.2 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Med5 PF08689.5 EFE38156.1 - 6e-250 831.9 0.0 6.9e-248 825.1 0.0 2.0 1 1 0 1 1 1 1 Mediator complex subunit Med5 DUF3782 PF12644.2 EFE38156.1 - 0.14 12.0 0.0 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3782) Tyr-DNA_phospho PF06087.7 EFE38158.1 - 8.5e-42 143.3 0.0 1.3e-41 142.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase UIM PF02809.15 EFE38158.1 - 0.17 11.5 0.1 0.17 11.5 0.1 3.3 3 0 0 3 3 3 0 Ubiquitin interaction motif NAD_binding_8 PF13450.1 EFE38159.1 - 1.7e-13 50.3 0.2 3.3e-12 46.2 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFE38159.1 - 9.4e-09 34.6 0.0 2.5e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFE38159.1 - 2.4e-08 34.0 0.1 0.00051 19.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFE38159.1 - 2.3e-06 26.7 0.2 4.3e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EFE38159.1 - 5.4e-06 25.1 0.4 6.5e-05 21.5 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.19 EFE38159.1 - 9.6e-06 24.9 0.0 0.0037 16.4 0.0 2.9 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 EFE38159.1 - 2.1e-05 24.8 0.2 0.14 12.5 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE38159.1 - 4.5e-05 23.6 0.4 0.00091 19.3 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFE38159.1 - 0.00017 20.7 0.0 0.00035 19.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.2 EFE38159.1 - 0.00067 18.8 0.0 0.0058 15.7 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFE38159.1 - 0.0029 16.5 0.1 0.0047 15.8 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.9 EFE38159.1 - 0.0038 15.9 0.6 0.0089 14.7 0.0 1.9 3 0 0 3 3 3 1 Tryptophan halogenase NAD_binding_9 PF13454.1 EFE38159.1 - 0.0062 16.3 1.2 0.034 13.9 0.0 2.7 4 0 0 4 4 3 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 EFE38159.1 - 0.032 13.2 0.1 0.12 11.4 0.1 1.9 2 1 0 2 2 2 0 FAD binding domain GIDA PF01134.17 EFE38159.1 - 0.033 13.0 0.1 0.059 12.2 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A ApbA PF02558.11 EFE38159.1 - 0.11 11.9 0.0 0.44 9.9 0.0 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 EFE38159.1 - 0.13 12.7 0.0 1.5 9.2 0.0 2.4 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent GMC_oxred_N PF00732.14 EFE38159.1 - 0.16 11.0 0.0 12 4.9 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase Malic_M PF03949.10 EFE38159.1 - 0.21 11.1 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain adh_short PF00106.20 EFE38160.1 - 3.5e-21 75.8 0.0 4.8e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE38160.1 - 2.9e-10 40.0 0.0 4.4e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE38160.1 - 6e-06 25.8 0.0 1.2e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFE38160.1 - 0.00014 21.9 0.0 0.00029 20.8 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 EFE38160.1 - 0.0013 17.7 0.0 0.0021 17.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EFE38160.1 - 0.0018 17.2 0.0 0.0023 16.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 EFE38160.1 - 0.0053 16.0 0.0 0.012 14.8 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.14 EFE38160.1 - 0.019 13.6 0.1 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sec1 PF00995.18 EFE38161.1 - 4.3e-145 484.5 0.0 5.2e-145 484.2 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF3605 PF12239.3 EFE38162.1 - 4.3e-45 153.3 2.2 7.4e-45 152.6 1.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) GIDA PF01134.17 EFE38163.1 - 2.2e-127 425.1 0.0 4.3e-127 424.2 0.0 1.4 2 0 0 2 2 2 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 EFE38163.1 - 1.3e-16 60.4 0.0 3.3e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 GidA associated domain 3 ARD PF03079.9 EFE38164.1 - 3e-48 163.7 0.2 3.5e-48 163.4 0.1 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 EFE38164.1 - 4.9e-09 35.5 0.0 7.8e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 EFE38164.1 - 3.6e-05 23.4 0.0 5.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 EFE38164.1 - 0.007 15.8 0.0 0.0093 15.4 0.0 1.2 1 0 0 1 1 1 1 Cupin DUF2404 PF10296.4 EFE38165.1 - 5.7e-06 26.3 0.0 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) DUF1183 PF06682.7 EFE38166.1 - 1.9e-79 267.5 10.3 4.5e-79 266.3 7.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1183) Myb_DNA-binding PF00249.26 EFE38167.1 - 7.5e-05 22.7 0.0 0.0013 18.7 0.0 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain FTZ PF03867.9 EFE38167.1 - 3.1 6.9 6.0 2 7.5 2.0 2.0 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region BRE1 PF08647.6 EFE38168.1 - 4e-24 84.4 14.4 4e-24 84.4 10.0 6.5 4 2 1 6 6 6 1 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.1 EFE38168.1 - 1.5e-09 37.7 10.7 2.5e-09 37.0 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE38168.1 - 6.6e-09 35.3 8.4 1.1e-08 34.5 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE38168.1 - 8.4e-08 31.7 10.8 1.5e-07 30.9 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE38168.1 - 2.4e-07 30.4 8.3 4.7e-07 29.5 5.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EFE38168.1 - 2.9e-06 26.9 11.4 5.3e-06 26.0 7.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 EFE38168.1 - 1.2e-05 24.9 6.5 3.6e-05 23.3 4.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Reo_sigmaC PF04582.7 EFE38168.1 - 2.6e-05 23.5 38.2 0.0026 16.9 0.9 4.7 2 1 3 5 5 5 3 Reovirus sigma C capsid protein zf-C3HC4_4 PF15227.1 EFE38168.1 - 0.0019 18.0 7.2 0.0036 17.1 5.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 EFE38168.1 - 0.0024 17.9 2.6 0.0066 16.5 1.8 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger Prok-RING_4 PF14447.1 EFE38168.1 - 0.032 13.7 3.8 0.067 12.7 2.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.1 EFE38168.1 - 0.033 13.7 7.6 0.12 11.9 5.3 1.9 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DUF1272 PF06906.6 EFE38168.1 - 0.043 13.6 6.0 0.094 12.5 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_6 PF14835.1 EFE38168.1 - 0.12 12.1 3.9 0.24 11.2 2.7 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.3 EFE38168.1 - 0.13 11.8 6.1 0.33 10.4 4.2 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit IncA PF04156.9 EFE38168.1 - 0.96 9.0 83.6 0.23 11.0 1.0 5.3 1 1 3 5 5 4 0 IncA protein DZR PF12773.2 EFE38168.1 - 1.1 9.0 6.2 2.7 7.8 4.3 1.6 1 0 0 1 1 1 0 Double zinc ribbon FYVE PF01363.16 EFE38168.1 - 1.3 8.9 12.7 34 4.4 8.9 2.5 1 1 1 2 2 2 0 FYVE zinc finger zf-C2H2 PF00096.21 EFE38168.1 - 8 7.0 8.6 1.5 9.2 0.3 3.2 3 0 0 3 3 2 0 Zinc finger, C2H2 type Myosin_tail_1 PF01576.14 EFE38168.1 - 8.7 3.9 81.4 6.6e+02 -2.4 56.4 3.7 1 1 0 1 1 1 0 Myosin tail UreF PF01730.11 EFE38169.1 - 7e-14 52.1 3.8 1.3e-13 51.2 2.7 1.5 1 1 0 1 1 1 1 UreF DUF1138 PF06592.8 EFE38169.1 - 0.14 12.1 0.0 4.9 7.2 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1138) ABC1 PF03109.11 EFE38170.1 - 6e-33 113.3 0.0 1.4e-32 112.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Mannosyl_trans3 PF11051.3 EFE38171.1 - 1e-71 241.5 0.0 3.4e-71 239.7 0.0 1.8 1 1 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.15 EFE38171.1 - 0.03 13.6 0.1 0.081 12.2 0.0 1.6 1 1 0 1 1 1 0 Glycosyl transferase family 8 AMPKBI PF04739.10 EFE38172.1 - 0.0043 16.8 0.5 0.011 15.5 0.0 2.0 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interation domain DUF4399 PF14347.1 EFE38172.1 - 0.018 15.0 0.6 0.16 12.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4399) PDEase_II PF02112.10 EFE38175.1 - 3.1e-56 190.7 0.0 7.1e-27 94.2 0.0 3.2 3 1 0 3 3 3 3 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.2 EFE38175.1 - 1.7e-05 24.4 0.0 4.6e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EFE38175.1 - 0.0025 17.5 0.5 0.006 16.2 0.1 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Fungal_trans PF04082.13 EFE38176.1 - 5.7e-06 25.3 3.8 1e-05 24.5 0.3 2.6 2 1 1 3 3 3 2 Fungal specific transcription factor domain adh_short PF00106.20 EFE38177.1 - 2.2e-17 63.4 0.0 3.6e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE38177.1 - 2.7e-08 33.6 0.0 4.1e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 KR domain ALO PF04030.9 EFE38178.1 - 1.4e-89 300.1 0.1 2.2e-89 299.5 0.1 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 EFE38178.1 - 9.7e-32 109.3 0.1 1.5e-31 108.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF4045 PF13254.1 EFE38179.1 - 7.3e-118 394.4 42.8 7e-73 246.2 21.2 5.8 3 3 3 6 6 6 2 Domain of unknown function (DUF4045) Gelsolin PF00626.17 EFE38179.1 - 2.5e-11 43.1 0.0 0.0033 17.0 0.0 3.9 3 0 0 3 3 3 3 Gelsolin repeat Acetyltransf_4 PF13420.1 EFE38180.1 - 0.024 14.5 0.1 0.089 12.7 0.1 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DEAD PF00270.24 EFE38181.1 - 2.1e-43 147.7 0.1 5.7e-43 146.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE38181.1 - 7e-25 86.6 0.0 2.8e-24 84.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 EFE38181.1 - 0.0002 19.9 0.9 0.001 17.5 0.1 2.5 1 1 2 3 3 3 1 Protein of unknown function (DUF1253) HMGL-like PF00682.14 EFE38182.1 - 1.8e-59 201.3 0.0 3e-59 200.5 0.0 1.4 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 EFE38182.1 - 5.7e-21 74.6 0.0 1.1e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain AMP-binding PF00501.23 EFE38183.1 - 9.9e-57 192.1 1.0 2.6e-23 82.1 0.0 4.9 4 1 0 4 4 4 4 AMP-binding enzyme DMAP_binding PF06464.6 EFE38183.1 - 8.5e-10 39.2 0.0 2.6e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.7 EFE38183.1 - 0.0009 19.0 0.2 0.0021 17.8 0.1 1.6 1 0 0 1 1 1 1 Gas vesicle protein G Carb_anhydrase PF00194.16 EFE38184.1 - 1e-25 90.2 0.3 3.9e-25 88.2 0.2 1.8 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase RNR_inhib PF08591.5 EFE38185.1 - 1.1e-17 64.7 0.2 1.1e-17 64.7 0.2 1.9 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor SDA1 PF05285.7 EFE38186.1 - 5.1e-92 308.6 35.6 5.1e-92 308.6 24.6 2.2 2 0 0 2 2 2 1 SDA1 NUC130_3NT PF08158.7 EFE38186.1 - 6.7e-23 80.7 0.1 1.9e-22 79.2 0.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain Ribosomal_S7 PF00177.16 EFE38187.1 - 8.4e-41 138.9 1.2 1e-40 138.7 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e p450 PF00067.17 EFE38189.1 - 1.7e-50 171.9 0.0 6.2e-50 170.0 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.20 EFE38190.1 - 2.9e-17 62.6 0.0 2.4e-16 59.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38190.1 - 2.1e-06 26.9 0.1 0.019 14.0 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Metallophos PF00149.23 EFE38192.1 - 7e-09 35.3 1.3 1.3e-08 34.5 0.9 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.13 EFE38192.1 - 0.0023 17.8 0.0 0.01 15.8 0.0 2.0 1 1 1 2 2 2 1 5'-nucleotidase, C-terminal domain DmpG_comm PF07836.6 EFE38192.1 - 0.13 11.6 0.0 0.55 9.6 0.0 2.0 2 0 0 2 2 2 0 DmpG-like communication domain Pkinase PF00069.20 EFE38193.1 - 5.2e-11 42.1 0.0 4e-10 39.2 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain 4HBT_3 PF13622.1 EFE38194.1 - 7.6e-32 111.0 0.4 9.9e-32 110.6 0.3 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 EFE38194.1 - 4.7e-21 74.7 0.0 1.5e-10 40.7 0.0 3.1 3 0 0 3 3 3 3 Acyl-CoA thioesterase DUF3445 PF11927.3 EFE38195.1 - 2.1e-59 200.9 0.0 2.7e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Lipase_GDSL_3 PF14606.1 EFE38195.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family HSP70 PF00012.15 EFE38196.1 - 1.6e-10 39.5 0.1 4.4e-09 34.8 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein zf-SAP30 PF13866.1 EFE38196.1 - 0.0053 16.3 0.2 0.011 15.3 0.1 1.5 1 0 0 1 1 1 1 SAP30 zinc-finger MreB_Mbl PF06723.8 EFE38196.1 - 0.11 11.0 0.0 0.32 9.5 0.0 1.6 2 0 0 2 2 2 0 MreB/Mbl protein APC10 PF03256.11 EFE38197.1 - 7.8e-43 146.3 0.0 2.7e-42 144.5 0.0 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) PI3K_1B_p101 PF10486.4 EFE38197.1 - 0.27 8.7 1.6 0.37 8.2 1.1 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Daxx PF03344.10 EFE38197.1 - 0.31 9.4 28.7 0.028 12.9 11.8 2.1 2 0 0 2 2 2 0 Daxx Family NARP1 PF12569.3 EFE38197.1 - 3.9 6.1 10.8 0.24 10.1 0.1 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 FYDLN_acid PF09538.5 EFE38197.1 - 5 7.7 31.9 3.4 8.2 6.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF3306 PF11748.3 EFE38197.1 - 7.3 7.2 12.8 5.6 7.6 3.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Iso_dh PF00180.15 EFE38198.1 - 1.4e-127 425.4 0.0 1.6e-127 425.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF788 PF05620.6 EFE38199.1 - 1.5e-38 132.3 0.0 1.9e-38 132.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF788) Prominin PF05478.6 EFE38200.1 - 0.064 10.7 4.4 0.09 10.2 1.4 2.0 2 0 0 2 2 2 0 Prominin PEP-utilisers_N PF05524.8 EFE38200.1 - 0.39 10.5 6.4 0.1 12.4 0.3 2.8 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal RINGv PF12906.2 EFE38201.1 - 1.2e-15 57.2 10.4 2e-15 56.5 7.2 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 EFE38201.1 - 0.097 12.5 8.4 0.18 11.6 5.8 1.4 1 0 0 1 1 1 0 Ring finger domain Zip PF02535.17 EFE38201.1 - 0.14 11.1 4.0 0.087 11.8 0.1 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter Ycf1 PF05758.7 EFE38201.1 - 0.14 9.8 0.2 0.37 8.4 0.0 1.6 2 0 0 2 2 2 0 Ycf1 zf-C3HC4_3 PF13920.1 EFE38201.1 - 0.23 11.1 5.4 0.38 10.4 3.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFE38201.1 - 0.34 10.7 3.6 0.76 9.6 2.5 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TRAP_alpha PF03896.11 EFE38201.1 - 0.57 9.1 2.3 1 8.3 1.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit zf-RING_4 PF14570.1 EFE38201.1 - 1.4 8.5 6.9 2.4 7.7 4.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4611 PF15387.1 EFE38201.1 - 2.6 8.2 10.1 11 6.2 7.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RRN3 PF05327.6 EFE38201.1 - 2.7 5.9 1.6 4.4 5.2 1.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FANCL_C PF11793.3 EFE38201.1 - 3.4 7.7 6.7 7.5 6.5 4.7 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain VID27 PF08553.5 EFE38201.1 - 7 4.7 6.9 10 4.2 4.8 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein Herpes_UL6 PF01763.11 EFE38202.1 - 0.048 11.8 0.2 0.51 8.4 0.0 2.0 2 0 0 2 2 2 0 Herpesvirus UL6 like ACC_central PF08326.7 EFE38203.1 - 3.7e-262 871.5 0.0 4.9e-262 871.1 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 EFE38203.1 - 1.2e-181 604.3 0.0 2.5e-181 603.3 0.0 1.5 2 0 0 2 2 2 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 EFE38203.1 - 1.3e-53 181.4 0.0 2.5e-53 180.4 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 EFE38203.1 - 7.2e-23 80.6 0.0 1.1e-19 70.3 0.0 3.2 3 0 0 3 3 3 2 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 EFE38203.1 - 7.1e-15 54.4 0.0 2e-14 52.9 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 EFE38203.1 - 3.9e-11 43.0 0.0 1e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EFE38203.1 - 5.2e-06 25.4 0.0 5e-05 22.1 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EFE38203.1 - 2.5e-05 23.7 0.0 6.9e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 EFE38203.1 - 0.00028 20.7 0.0 0.00062 19.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 EFE38203.1 - 0.012 14.9 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.6 EFE38203.1 - 0.017 14.6 0.0 4.4 6.7 0.0 2.4 2 0 0 2 2 2 0 RimK-like ATP-grasp domain SRA1 PF07304.6 EFE38203.1 - 0.16 11.7 0.8 0.72 9.5 0.0 2.2 2 0 0 2 2 2 0 Steroid receptor RNA activator (SRA1) Gryzun PF07919.7 EFE38203.1 - 0.36 9.1 0.0 0.64 8.2 0.0 1.3 1 0 0 1 1 1 0 Gryzun, putative trafficking through Golgi DUF4487 PF14868.1 EFE38203.1 - 0.72 8.4 0.0 1.1 7.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) CPSase_L_chain PF00289.17 EFE38204.1 - 1.4e-06 28.3 0.1 2.2e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain NUDE_C PF04880.8 EFE38205.1 - 1.6e-23 83.9 8.0 1.6e-23 83.9 5.6 3.9 4 0 0 4 4 4 1 NUDE protein, C-terminal conserved region WEMBL PF05701.6 EFE38205.1 - 0.00013 20.6 27.6 0.00018 20.1 19.1 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DMPK_coil PF08826.5 EFE38205.1 - 0.033 14.0 1.3 0.033 14.0 0.9 4.6 3 2 2 5 5 5 0 DMPK coiled coil domain like CCDC144C PF14915.1 EFE38205.1 - 0.33 9.8 26.0 5.5 5.8 18.1 2.3 2 1 0 2 2 2 0 CCDC144C protein coiled-coil region ADIP PF11559.3 EFE38205.1 - 0.4 10.5 26.2 3.8 7.4 3.2 3.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 EFE38205.1 - 2.6 7.5 32.7 1.4 8.5 12.6 2.6 2 1 1 3 3 3 0 IncA protein DUF1664 PF07889.7 EFE38205.1 - 3.3 7.5 8.0 0.32 10.7 1.4 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 EFE38205.1 - 4.9 7.0 31.8 2.7 7.8 15.9 3.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF904 PF06005.7 EFE38205.1 - 6.9 7.0 32.1 0.11 12.8 5.1 4.4 2 1 1 3 3 3 0 Protein of unknown function (DUF904) ATG16 PF08614.6 EFE38205.1 - 8.2 6.1 30.6 2.7 7.7 11.9 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Hexokinase_2 PF03727.11 EFE38206.1 - 1.1e-21 77.1 0.0 2.5e-18 66.1 0.0 2.3 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.16 EFE38206.1 - 1.8e-20 73.1 0.0 1e-19 70.6 0.0 2.1 1 1 0 1 1 1 1 Hexokinase Isochorismatase PF00857.15 EFE38207.1 - 1.4e-37 129.2 0.0 6.6e-37 127.0 0.0 1.9 2 0 0 2 2 2 1 Isochorismatase family FAR1 PF03101.10 EFE38207.1 - 2.4e-07 31.1 0.0 6.7e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 FAR1 DNA-binding domain AFT PF08731.6 EFE38207.1 - 0.064 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Transcription factor AFT DUF2040 PF09745.4 EFE38208.1 - 4.8e-42 142.8 11.8 4.8e-42 142.8 8.1 4.0 3 1 1 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) Zip PF02535.17 EFE38209.1 - 6.6e-21 74.6 11.1 6.3e-20 71.4 7.7 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter MFS_1_like PF12832.2 EFE38209.1 - 0.032 14.0 0.1 0.07 12.9 0.1 1.6 1 0 0 1 1 1 0 MFS_1 like family Endonuclease_NS PF01223.18 EFE38210.1 - 4.4e-60 202.8 0.0 5.9e-60 202.4 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sec7 PF01369.15 EFE38212.1 - 9.4e-39 133.0 0.1 1.6e-38 132.3 0.1 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 EFE38212.1 - 3e-06 27.3 0.0 6.9e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 EFE38212.1 - 5.6e-05 23.2 0.0 0.00014 21.9 0.0 1.8 1 0 0 1 1 1 1 PH domain zf-C3HC4_2 PF13923.1 EFE38213.1 - 1.2e-10 41.1 8.9 2.3e-05 24.2 0.9 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE38213.1 - 3.1e-05 23.6 10.4 0.0015 18.3 2.9 2.9 2 1 1 3 3 3 2 Ring finger domain zf-RING_5 PF14634.1 EFE38213.1 - 6.7e-05 22.5 4.8 6.7e-05 22.5 3.3 2.8 2 1 0 2 2 2 1 zinc-RING finger domain Rtf2 PF04641.7 EFE38213.1 - 9.5e-05 21.7 1.7 9.5e-05 21.7 1.2 3.2 2 1 1 3 3 2 2 Rtf2 RING-finger zf-RING_UBOX PF13445.1 EFE38213.1 - 0.00013 21.6 1.3 0.00013 21.6 0.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.20 EFE38213.1 - 0.0037 16.8 1.3 0.0037 16.8 0.9 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.16 EFE38213.1 - 0.0046 16.8 15.4 0.14 12.0 5.1 4.1 2 2 1 3 3 3 2 FYVE zinc finger zf-C3HC4_3 PF13920.1 EFE38213.1 - 0.017 14.8 15.1 0.019 14.6 4.8 3.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SEP PF08059.8 EFE38213.1 - 0.033 14.4 0.0 0.081 13.2 0.0 1.6 1 0 0 1 1 1 0 SEP domain DUF1195 PF06708.6 EFE38213.1 - 0.042 13.2 0.1 0.073 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) IBR PF01485.16 EFE38213.1 - 0.083 12.7 9.2 2.4 8.1 0.7 3.7 3 0 0 3 3 3 0 IBR domain zf-C3HC4_4 PF15227.1 EFE38213.1 - 0.1 12.4 11.2 0.049 13.5 2.6 3.4 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 EFE38213.1 - 0.12 11.9 3.5 0.35 10.4 1.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 UPF1_Zn_bind PF09416.5 EFE38213.1 - 0.91 9.0 5.5 4.7 6.7 0.2 2.5 2 1 0 2 2 2 0 RNA helicase (UPF2 interacting domain) Siva PF05458.7 EFE38213.1 - 1.2 8.6 6.6 0.26 10.8 1.0 2.0 2 0 0 2 2 2 0 Cd27 binding protein (Siva) Vfa1 PF08432.5 EFE38213.1 - 1.6 8.6 14.4 0.31 11.0 6.9 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Ycf1 PF05758.7 EFE38213.1 - 1.9 6.0 7.1 2.6 5.6 4.9 1.2 1 0 0 1 1 1 0 Ycf1 DZR PF12773.2 EFE38213.1 - 9.8 6.0 11.3 3.4 7.5 0.9 3.4 3 0 0 3 3 3 0 Double zinc ribbon SET PF00856.23 EFE38214.1 - 9.4e-14 52.0 0.0 2.6e-13 50.5 0.0 1.7 1 1 0 1 1 1 1 SET domain DUF3529 PF12046.3 EFE38214.1 - 0.05 12.6 0.1 0.078 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3529) SAF PF08666.7 EFE38214.1 - 0.087 13.2 0.0 13 6.2 0.0 2.4 2 0 0 2 2 2 0 SAF domain Peptidase_M14 PF00246.19 EFE38215.1 - 5.9e-66 222.9 0.0 7.9e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase NicO PF03824.11 EFE38216.1 - 9.6e-34 116.9 15.5 1.8e-29 102.9 1.1 2.7 2 1 1 3 3 3 2 High-affinity nickel-transport protein Peptidase_S8 PF00082.17 EFE38217.1 - 3e-48 164.3 12.0 4.7e-48 163.7 8.3 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE38217.1 - 2.2e-16 60.2 0.2 3.8e-16 59.4 0.2 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 DNA_pol_lambd_f PF10391.4 EFE38218.1 - 5e-20 70.8 0.7 9.7e-20 69.8 0.5 1.5 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_thumb PF14791.1 EFE38218.1 - 9.7e-19 66.8 0.0 4.9e-18 64.5 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.1 EFE38218.1 - 1.6e-17 63.5 0.0 9.1e-16 57.9 0.0 2.5 2 0 0 2 2 2 1 DNA polymerase beta palm HHH_8 PF14716.1 EFE38218.1 - 3.2e-09 36.8 0.0 8.4e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.18 EFE38218.1 - 0.002 18.3 0.0 0.0056 16.9 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF993 PF06187.6 EFE38218.1 - 0.12 10.8 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF993) HAD PF12710.2 EFE38219.1 - 5.2e-21 75.6 0.1 1.3e-20 74.3 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EFE38219.1 - 3e-19 68.9 0.2 5.1e-19 68.2 0.1 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EFE38219.1 - 6.8e-16 59.3 0.0 3.7e-15 56.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE38219.1 - 1.3e-12 47.4 0.0 7.1e-12 45.1 0.0 2.2 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFE38219.1 - 0.001 18.7 0.3 0.0069 15.9 0.2 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFE38219.1 - 0.017 15.3 0.1 0.056 13.6 0.0 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase RNase_PH PF01138.16 EFE38220.1 - 3.8e-18 66.0 0.0 8.3e-18 64.9 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EFE38220.1 - 3.4e-07 30.1 0.2 7.4e-07 29.0 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 WD40 PF00400.27 EFE38221.1 - 4.4e-46 153.1 26.1 2.1e-09 36.8 1.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat eIF2A PF08662.6 EFE38221.1 - 0.023 14.4 0.2 0.18 11.5 0.1 2.2 1 1 2 3 3 3 0 Eukaryotic translation initiation factor eIF2A Ytp1 PF10355.4 EFE38222.1 - 2.1e-80 269.8 20.2 9.7e-56 188.9 3.9 3.0 2 2 1 3 3 3 2 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EFE38222.1 - 2.6e-30 104.1 8.2 2.6e-30 104.1 5.7 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) RTA1 PF04479.8 EFE38223.1 - 7.6e-45 153.1 0.5 1.2e-44 152.4 0.3 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF4131 PF13567.1 EFE38223.1 - 3.8 6.8 11.9 3.3 7.0 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Gaa1 PF04114.9 EFE38224.1 - 4.2e-98 329.2 6.1 5.1e-98 328.9 4.2 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.22 EFE38225.1 - 2e-10 40.8 0.1 4.6e-10 39.7 0.1 1.7 1 0 0 1 1 1 1 PCI domain Methyltransf_31 PF13847.1 EFE38226.1 - 7.8e-10 38.5 0.0 1.1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38226.1 - 4.3e-09 36.7 0.0 1.2e-08 35.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38226.1 - 1.4e-08 34.6 0.0 1.9e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38226.1 - 1.8e-08 34.7 0.0 5.1e-08 33.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38226.1 - 3.1e-08 34.1 0.0 6.4e-08 33.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38226.1 - 2.8e-05 24.4 0.0 5.4e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE38226.1 - 0.0005 19.2 0.0 0.00096 18.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GMC_oxred_N PF00732.14 EFE38227.1 - 1.7e-43 148.9 0.0 2.4e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFE38227.1 - 2.5e-38 131.5 0.0 3.6e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_10 PF13460.1 EFE38229.1 - 3.7e-10 40.0 0.0 5.6e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFE38229.1 - 1.2e-06 28.1 0.0 2.8e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFE38229.1 - 3.4e-05 22.6 0.1 6.6e-05 21.7 0.1 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 EFE38229.1 - 0.00071 18.9 0.0 0.001 18.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family HIM1 PF08732.5 EFE38229.1 - 0.0096 14.4 0.0 0.014 13.8 0.0 1.2 1 0 0 1 1 1 1 HIM1 RmlD_sub_bind PF04321.12 EFE38229.1 - 0.14 11.0 0.0 0.41 9.4 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain GHL12 PF14882.1 EFE38231.1 - 1.8 8.7 3.9 0.54 10.4 0.3 2.0 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 12 fn3 PF00041.16 EFE38232.1 - 4.2e-12 46.0 4.5 2.9e-07 30.5 0.0 3.3 3 1 0 3 3 3 2 Fibronectin type III domain Lipase_GDSL_2 PF13472.1 EFE38232.1 - 9.8e-08 32.3 0.9 9.8e-08 32.3 0.6 2.3 3 1 0 3 3 3 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFE38232.1 - 5.9e-07 29.5 0.0 2.1e-06 27.7 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase HEM4 PF02602.10 EFE38233.1 - 3e-22 78.9 0.0 2.9e-20 72.4 0.0 2.5 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Pkinase PF00069.20 EFE38234.1 - 5.2e-70 235.5 0.0 7.2e-70 235.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38234.1 - 7.4e-29 100.5 0.0 1.1e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE38234.1 - 0.0005 19.1 0.0 0.0013 17.7 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFE38234.1 - 0.0081 15.2 0.2 0.016 14.2 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE38234.1 - 0.019 14.7 0.1 0.032 13.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinesin PF00225.18 EFE38235.1 - 1.9e-80 270.1 0.2 2.6e-80 269.6 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Sec23_trunk PF04811.10 EFE38235.1 - 4.5e-71 239.0 0.0 7.4e-70 235.0 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EFE38235.1 - 1.3e-21 75.9 0.0 8.6e-21 73.3 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 EFE38235.1 - 1.5e-17 62.8 4.3 2.8e-17 61.9 3.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 EFE38235.1 - 1.3e-16 60.8 0.0 3.2e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 EFE38235.1 - 6e-06 25.8 0.0 1.4e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat HHH PF00633.18 EFE38235.1 - 0.014 15.0 0.0 0.057 13.1 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif TPR_12 PF13424.1 EFE38235.1 - 0.087 12.7 1.2 1.3 9.0 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.11 EFE38236.1 - 4.2e-23 81.6 65.7 1.3e-17 63.6 22.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE38236.1 - 2.5e-08 32.7 19.1 2.5e-08 32.7 13.2 1.8 1 1 1 2 2 2 1 MFS/sugar transport protein OapA_N PF08525.6 EFE38236.1 - 0.39 10.5 3.5 1.4 8.7 2.4 2.0 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif HTH_28 PF13518.1 EFE38237.1 - 0.0017 18.2 0.4 0.005 16.8 0.2 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain LZ_Tnp_IS481 PF13011.1 EFE38237.1 - 0.048 13.9 1.4 0.13 12.6 1.0 1.8 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 DUF1323 PF07037.6 EFE38237.1 - 0.05 13.7 0.9 0.35 11.0 0.1 2.2 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) CtIP_N PF10482.4 EFE38237.1 - 0.14 11.9 6.3 2 8.2 0.0 3.0 2 1 1 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain EzrA PF06160.7 EFE38237.1 - 0.21 9.7 3.6 0.33 9.0 2.5 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Snf7 PF03357.16 EFE38237.1 - 1.5 8.1 8.0 2 7.7 4.6 1.7 2 0 0 2 2 2 0 Snf7 DUF4544 PF15077.1 EFE38237.1 - 1.9 7.9 3.8 1.9 7.9 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4544) MCPVI PF02993.9 EFE38237.1 - 8.2 6.5 10.6 3.4 7.7 5.7 1.5 1 1 0 1 1 1 0 Minor capsid protein VI Chromate_transp PF02417.10 EFE38238.1 - 1.8e-60 203.3 33.3 8.5e-33 113.3 8.1 2.5 2 1 0 2 2 2 2 Chromate transporter Peptidase_M43 PF05572.8 EFE38240.1 - 1.2e-15 57.3 0.3 2.6e-15 56.3 0.2 1.6 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_4 PF13583.1 EFE38240.1 - 4e-05 23.2 2.2 0.00034 20.2 0.1 2.2 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 EFE38240.1 - 7.4e-05 22.8 6.2 0.00014 21.9 4.3 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 EFE38240.1 - 0.00046 20.1 1.9 0.00084 19.3 1.3 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 EFE38240.1 - 0.0062 17.0 2.1 0.034 14.6 1.4 2.3 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M7 PF02031.11 EFE38240.1 - 0.013 15.2 0.1 0.035 13.8 0.1 1.7 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M57 PF12388.3 EFE38240.1 - 0.031 13.6 2.7 0.034 13.4 0.3 1.9 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.19 EFE38240.1 - 0.11 12.2 0.3 0.14 11.8 0.2 1.3 1 1 0 1 1 1 0 Matrixin CPSase_L_D2 PF02786.12 EFE38241.1 - 1.9e-106 354.0 0.0 3.7e-83 277.9 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 EFE38241.1 - 2.1e-42 143.7 0.1 4.6e-42 142.6 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 EFE38241.1 - 2.6e-36 125.0 0.0 7.9e-20 71.3 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_chain PF00289.17 EFE38241.1 - 1.7e-32 111.7 0.0 8.4e-17 61.2 0.0 2.6 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 EFE38241.1 - 2.2e-22 79.2 0.0 1.4e-07 30.6 0.0 4.0 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EFE38241.1 - 1.1e-17 63.9 0.0 9.6e-08 31.5 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFE38241.1 - 1.6e-14 53.7 0.1 1.3e-06 28.0 0.0 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus RimK PF08443.6 EFE38241.1 - 2e-09 37.2 0.0 2.7e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.14 EFE38241.1 - 0.00033 20.2 0.0 0.067 12.7 0.0 2.4 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.9 EFE38241.1 - 0.00038 20.3 0.0 0.44 10.4 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_5 PF13549.1 EFE38241.1 - 0.00078 18.7 0.0 0.1 11.7 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain Pkinase_Tyr PF07714.12 EFE38243.1 - 2.7e-06 26.6 0.0 0.0002 20.4 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 EFE38243.1 - 5.2e-06 25.8 0.0 6.4e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFE38243.1 - 2.6e-05 24.0 0.1 4.1e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFE38243.1 - 0.00067 19.0 0.0 0.0009 18.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 EFE38243.1 - 0.0008 18.5 0.1 0.0018 17.3 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE38243.1 - 0.0068 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.1 EFE38243.1 - 0.0069 15.3 0.0 0.0081 15.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like EcKinase PF02958.15 EFE38243.1 - 0.03 13.4 0.1 0.047 12.8 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Seadorna_VP7 PF07387.6 EFE38243.1 - 0.04 12.7 0.0 0.064 12.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 SIR2_2 PF13289.1 EFE38243.1 - 0.15 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 SIR2-like domain SET PF00856.23 EFE38244.1 - 4.8e-13 49.7 0.5 3.7e-12 46.8 0.0 2.5 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.13 EFE38244.1 - 8.2e-10 38.4 6.5 8.2e-10 38.4 4.5 2.2 2 0 0 2 2 2 1 MYND finger Rtf2 PF04641.7 EFE38244.1 - 0.00042 19.5 0.1 0.00073 18.8 0.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger Ribosomal_S19 PF00203.16 EFE38245.1 - 1.7e-31 107.6 0.2 2.5e-31 107.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 SbcD_C PF12320.3 EFE38245.1 - 0.022 14.7 0.3 0.54 10.3 0.0 2.0 1 1 1 2 2 2 0 Type 5 capsule protein repressor C-terminal domain Ribosomal_60s PF00428.14 EFE38246.1 - 5.4e-28 97.2 10.0 6.3e-28 97.0 6.9 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3138 PF11336.3 EFE38246.1 - 0.051 11.7 0.8 0.048 11.8 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF4611 PF15387.1 EFE38246.1 - 0.34 11.1 3.8 5.2 7.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) SPT2 PF08243.6 EFE38247.1 - 6.6e-09 36.0 11.8 6.6e-09 36.0 8.2 2.1 2 0 0 2 2 2 1 SPT2 chromatin protein Carb_kinase PF01256.12 EFE38248.1 - 9.1e-46 156.1 0.9 1.8e-42 145.3 0.1 3.0 2 1 0 2 2 2 2 Carbohydrate kinase SRA1 PF07304.6 EFE38248.1 - 0.0064 16.2 0.2 0.49 10.1 0.0 2.4 2 0 0 2 2 2 2 Steroid receptor RNA activator (SRA1) zf-C2H2_4 PF13894.1 EFE38249.1 - 2.6e-05 24.2 36.3 0.83 10.1 0.3 7.5 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE38249.1 - 2.8e-05 24.2 39.0 0.045 14.1 0.5 6.8 6 0 0 6 6 6 5 Zinc finger, C2H2 type Peptidase_S8 PF00082.17 EFE38250.1 - 4.1e-38 131.1 7.0 5.6e-38 130.6 4.9 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE38250.1 - 4e-13 49.7 0.0 7.4e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Trypan_PARP PF05887.6 EFE38250.1 - 4.5 7.0 24.1 8.6 6.1 16.7 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) zf-C2H2 PF00096.21 EFE38251.1 - 0.0016 18.6 25.5 0.15 12.4 0.3 4.8 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE38251.1 - 5.9 7.4 25.2 8 7.0 0.4 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger VirB3 PF05101.8 EFE38252.1 - 0.076 12.9 0.2 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein Reo_sigmaC PF04582.7 EFE38253.1 - 0.0014 17.8 9.1 0.078 12.1 1.8 2.6 1 1 0 2 2 2 2 Reovirus sigma C capsid protein DUF4187 PF13821.1 EFE38253.1 - 1.7 8.2 5.7 0.78 9.3 0.4 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4187) Methyltransf_16 PF10294.4 EFE38254.1 - 0.014 14.8 0.0 1.8 8.0 0.0 2.5 2 0 0 2 2 2 0 Putative methyltransferase Peptidase_M36 PF02128.10 EFE38255.1 - 3.4e-159 529.7 3.3 4.3e-159 529.3 2.3 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.8 EFE38255.1 - 6.8e-14 51.0 1.0 1.5e-13 50.0 0.7 1.6 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.10 EFE38255.1 - 0.073 12.8 0.0 0.21 11.3 0.0 1.8 1 1 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain Med22 PF06179.7 EFE38257.1 - 3e-22 78.7 2.5 3.6e-22 78.4 1.7 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex GPW_gp25 PF04965.9 EFE38257.1 - 0.036 13.5 1.1 0.063 12.8 0.2 1.7 2 0 0 2 2 2 0 Gene 25-like lysozyme Laminin_II PF06009.7 EFE38257.1 - 0.056 13.2 1.4 0.086 12.6 1.0 1.4 1 1 0 1 1 1 0 Laminin Domain II Phi-29_GP16_7 PF06720.6 EFE38257.1 - 0.17 11.5 5.8 1.9 8.1 0.1 2.0 1 1 0 2 2 2 0 Bacteriophage phi-29 early protein GP16.7 DHFR_1 PF00186.14 EFE38258.1 - 2.9e-18 65.9 0.2 1.5e-08 34.3 0.0 3.6 2 1 2 4 4 4 3 Dihydrofolate reductase Voltage_CLC PF00654.15 EFE38259.1 - 1.1e-88 297.6 23.6 2e-88 296.8 14.1 2.0 2 0 0 2 2 2 2 Voltage gated chloride channel Lipase_GDSL_2 PF13472.1 EFE38260.1 - 1.4e-20 74.1 0.0 1.8e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFE38260.1 - 1.5e-18 67.5 0.0 1.9e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Isochorismatase PF00857.15 EFE38262.1 - 1.2e-25 90.4 0.0 1.6e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family HK PF02110.10 EFE38263.1 - 1.4e-72 243.8 1.4 2.3e-72 243.1 0.2 1.9 2 1 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.12 EFE38263.1 - 6.2e-48 162.2 5.9 4.9e-27 94.2 0.1 2.7 2 0 0 2 2 2 2 Thiamine monophosphate synthase/TENI QRPTase_C PF01729.14 EFE38263.1 - 0.0019 17.7 0.0 0.0049 16.4 0.0 1.6 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain PfkB PF00294.19 EFE38263.1 - 0.022 13.8 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 pfkB family carbohydrate kinase PC_rep PF01851.17 EFE38265.1 - 1e-20 72.7 13.4 8.1e-05 22.6 0.1 8.7 9 0 0 9 9 9 3 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EFE38265.1 - 0.0002 21.5 0.6 1.2 9.4 0.0 4.1 3 1 0 3 3 3 2 HEAT repeats TPR_5 PF12688.2 EFE38265.1 - 0.036 14.1 1.0 4.6 7.3 0.0 3.2 3 0 0 3 3 3 0 Tetratrico peptide repeat DUF106 PF01956.11 EFE38265.1 - 0.06 12.8 0.1 13 5.2 0.0 2.4 2 0 0 2 2 2 0 Integral membrane protein DUF106 DUF1987 PF09345.5 EFE38265.1 - 0.15 11.8 1.5 7.3 6.4 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1987) BTK PF00779.14 EFE38266.1 - 0.034 13.7 2.0 0.082 12.5 1.4 1.7 1 0 0 1 1 1 0 BTK motif Radical_SAM PF04055.16 EFE38268.1 - 3.2e-14 53.4 0.1 8.6e-14 52.0 0.1 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 EFE38268.1 - 3.6e-08 33.4 0.3 8.1e-08 32.3 0.2 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EFE38268.1 - 1.6e-07 31.5 0.3 3.2e-07 30.5 0.2 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain GTP_EFTU PF00009.22 EFE38269.1 - 1.2e-60 204.2 0.0 1.6e-60 203.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EFE38269.1 - 3.6e-22 78.3 0.0 7.8e-22 77.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFE38269.1 - 7.7e-18 64.3 1.9 1.9e-17 63.1 1.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFE38269.1 - 1.8e-05 24.6 0.0 3.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE38269.1 - 0.00044 20.7 0.0 0.0008 19.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU_D4 PF14578.1 EFE38269.1 - 0.00067 19.2 0.2 0.0018 17.9 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 PduV-EutP PF10662.4 EFE38269.1 - 0.03 13.8 0.1 3.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Hepatitis_core PF00906.15 EFE38269.1 - 0.088 12.4 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Hepatitis core antigen cobW PF02492.14 EFE38269.1 - 0.1 12.0 0.3 0.56 9.6 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IF3_C PF00707.17 EFE38270.1 - 4.4e-14 51.9 1.1 7e-14 51.3 0.8 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.11 EFE38270.1 - 5.8e-10 38.9 1.4 6.4e-08 32.4 0.0 2.2 2 0 0 2 2 2 2 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.1 EFE38270.1 - 2.4e-07 30.2 1.8 2.1e-06 27.2 1.3 2.1 1 1 0 1 1 1 1 Mitochondrial translation initiation factor FACT-Spt16_Nlob PF14826.1 EFE38270.1 - 0.069 12.6 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 FACT complex subunit SPT16 N-terminal lobe domain GDA1_CD39 PF01150.12 EFE38271.1 - 1.4e-97 326.9 0.0 1.9e-97 326.5 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF4598 PF15370.1 EFE38272.1 - 1.2e-12 48.0 0.2 1.2e-12 48.0 0.1 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4598) DUF4349 PF14257.1 EFE38272.1 - 0.071 12.3 1.9 0.087 12.0 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) CDC45 PF02724.9 EFE38272.1 - 0.15 10.0 6.6 0.15 10.1 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.5 EFE38272.1 - 1.4 9.1 10.8 0.67 10.2 5.8 1.7 1 1 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.7 EFE38272.1 - 7.8 5.6 7.0 10 5.2 4.9 1.3 1 0 0 1 1 1 0 NOA36 protein IF4E PF01652.13 EFE38273.1 - 7.6e-33 113.3 0.3 9.2e-33 113.1 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E COMPASS-Shg1 PF05205.7 EFE38274.1 - 3.1e-30 104.6 0.1 3.1e-30 104.6 0.1 1.9 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 MIP-T3 PF10243.4 EFE38274.1 - 0.0001 20.9 45.1 0.00013 20.5 31.2 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Cation_efflux PF01545.16 EFE38277.1 - 4.8e-35 121.0 8.3 5.7e-35 120.7 5.8 1.0 1 0 0 1 1 1 1 Cation efflux family zf-rbx1 PF12678.2 EFE38278.1 - 2.2e-09 37.2 1.3 4e-09 36.4 0.9 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 EFE38278.1 - 7.5e-09 35.2 10.4 1.5e-07 31.1 7.2 2.3 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EFE38278.1 - 5.3e-07 29.2 3.6 1.6e-06 27.6 2.5 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFE38278.1 - 3.9e-06 26.4 6.2 1.8e-05 24.3 4.2 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE38278.1 - 3.9e-06 26.4 2.0 6.6e-06 25.6 1.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE38278.1 - 1.2e-05 25.1 3.1 1.2e-05 25.1 2.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFE38278.1 - 0.017 14.9 3.4 0.038 13.8 2.4 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2921 PF11145.3 EFE38278.1 - 0.067 10.9 0.6 0.099 10.3 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) KH_2 PF07650.12 EFE38278.1 - 0.15 11.6 0.0 0.38 10.3 0.0 1.6 1 0 0 1 1 1 0 KH domain FANCL_C PF11793.3 EFE38278.1 - 1.4 8.9 5.8 4.1 7.4 2.4 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.2 EFE38278.1 - 5.5 7.1 6.8 0.73 9.9 1.5 1.9 2 0 0 2 2 2 0 RING-variant domain zf-RING_UBOX PF13445.1 EFE38278.1 - 6.9 6.4 9.2 0.15 11.8 0.8 2.4 2 1 1 3 3 3 0 RING-type zinc-finger GCV_H PF01597.14 EFE38279.1 - 2.8e-39 133.5 0.8 3.3e-39 133.3 0.5 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 EFE38279.1 - 0.014 14.9 0.3 0.047 13.3 0.1 2.0 2 0 0 2 2 2 0 Biotin-requiring enzyme RnfC_N PF13375.1 EFE38279.1 - 0.027 14.1 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Dynamin_N PF00350.18 EFE38281.1 - 2.5e-44 151.0 0.1 6.2e-44 149.7 0.0 1.8 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.15 EFE38281.1 - 3.7e-10 39.0 0.3 8.3e-08 31.3 0.0 2.5 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.18 EFE38281.1 - 0.00085 19.2 0.0 0.0027 17.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE38281.1 - 0.0041 17.6 0.0 0.0095 16.4 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 EFE38281.1 - 0.047 13.6 1.4 0.43 10.5 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain GATase_4 PF13230.1 EFE38282.1 - 0.0035 16.0 0.0 0.029 13.0 0.0 1.9 1 1 1 2 2 2 2 Glutamine amidotransferases class-II PIG-Y PF15159.1 EFE38283.1 - 7.9 6.7 9.0 31 4.8 6.3 2.0 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y RRM_1 PF00076.17 EFE38284.1 - 6.6e-56 185.8 0.0 1.5e-20 72.6 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE38284.1 - 3.1e-40 135.9 0.1 1.7e-13 50.3 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE38284.1 - 6.5e-28 96.3 0.0 9.5e-10 38.1 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE38284.1 - 0.00015 21.4 0.0 5.7 6.7 0.0 3.9 3 1 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 EFE38284.1 - 0.0096 15.6 0.0 13 5.6 0.0 3.3 2 1 1 3 3 3 1 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.5 EFE38284.1 - 0.011 15.7 0.0 3 7.8 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) TFIIA PF03153.8 EFE38286.1 - 1.2 8.9 15.2 1.7 8.4 10.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arrestin_C PF02752.17 EFE38287.1 - 1.3e-17 64.2 0.0 1.1e-16 61.1 0.0 2.5 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EFE38287.1 - 4.3e-09 36.3 0.1 3e-05 23.8 0.0 2.7 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Fringe PF02434.11 EFE38288.1 - 4.2e-05 22.8 3.2 0.00036 19.8 0.9 2.6 2 1 0 2 2 2 1 Fringe-like PAN_1 PF00024.21 EFE38288.1 - 0.0091 15.7 0.2 0.031 14.0 0.2 1.8 2 0 0 2 2 2 1 PAN domain Acetyltransf_7 PF13508.1 EFE38289.1 - 2.2e-08 34.1 0.1 4.1e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE38289.1 - 2.8e-08 33.6 0.0 4.2e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFE38289.1 - 6.2e-06 26.3 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE38289.1 - 8.6e-06 25.6 0.1 0.011 15.5 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE38289.1 - 4.5e-05 23.1 0.0 7.9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 EFE38289.1 - 0.0028 17.5 0.0 0.0046 16.8 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Self-incomp_S1 PF05938.6 EFE38289.1 - 0.045 13.8 0.1 0.19 11.8 0.0 2.0 2 1 0 2 2 2 0 Plant self-incompatibility protein S1 DUF3609 PF12259.3 EFE38290.1 - 0.067 11.8 0.0 0.094 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3609) HemY_N PF07219.8 EFE38290.1 - 0.094 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 HemY protein N-terminus DUF1049 PF06305.6 EFE38290.1 - 0.18 11.3 0.1 0.28 10.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Pyr_redox_2 PF07992.9 EFE38291.1 - 2.4e-25 89.5 0.1 1.5e-14 54.3 0.0 3.4 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE38291.1 - 6.4e-13 48.9 0.0 2.5e-11 43.8 0.0 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE38291.1 - 0.00013 22.0 1.2 0.27 11.2 0.3 3.4 1 1 2 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Mito_fiss_reg PF05308.6 EFE38291.1 - 6.2 6.1 10.5 4.1 6.6 5.6 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator Podoplanin PF05808.6 EFE38293.1 - 0.0024 17.4 0.2 0.0053 16.3 0.1 1.5 1 0 0 1 1 1 1 Podoplanin DUF575 PF04746.7 EFE38293.1 - 0.0025 17.8 0.4 0.0045 17.0 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF575) Ashwin PF15323.1 EFE38293.1 - 0.018 15.0 0.1 0.027 14.4 0.1 1.3 1 0 0 1 1 1 0 Developmental protein DAP10 PF07213.6 EFE38293.1 - 0.024 14.3 0.6 0.6 9.9 0.1 2.3 2 0 0 2 2 2 0 DAP10 membrane protein TrbC PF04956.8 EFE38293.1 - 0.038 14.0 0.2 0.061 13.3 0.2 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family TMEM154 PF15102.1 EFE38293.1 - 0.042 13.5 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family PspB PF06667.7 EFE38293.1 - 0.088 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Phage shock protein B DUF1517 PF07466.6 EFE38293.1 - 0.26 10.2 2.7 0.23 10.3 1.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1517) Malate_synthase PF01274.17 EFE38294.1 - 6.5e-229 760.2 0.0 7.2e-229 760.1 0.0 1.0 1 0 0 1 1 1 1 Malate synthase PsbH PF00737.15 EFE38295.1 - 0.02 14.4 0.1 0.05 13.1 0.0 1.6 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein Pyr_redox_3 PF13738.1 EFE38297.1 - 1.7e-16 60.9 0.0 5.5e-16 59.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFE38297.1 - 1.2e-11 43.5 0.3 8.6e-09 34.1 0.1 2.7 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFE38297.1 - 4.2e-10 39.5 0.0 1.7e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFE38297.1 - 0.00035 19.5 0.2 0.64 8.8 0.0 2.4 3 0 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 EFE38297.1 - 0.00036 19.5 0.0 0.078 11.8 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EFE38297.1 - 0.0029 17.4 0.0 0.084 12.6 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFE38297.1 - 0.078 13.3 0.9 1.1 9.6 0.0 2.8 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE38297.1 - 0.1 11.0 0.3 0.24 9.8 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.12 EFE38297.1 - 0.14 11.2 0.0 0.38 9.8 0.0 1.6 2 0 0 2 2 2 0 Thi4 family Glyco_hydro_3 PF00933.16 EFE38298.1 - 1.9e-78 263.5 0.0 2.6e-78 263.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFE38298.1 - 3.2e-51 174.0 0.3 4.8e-50 170.1 0.2 2.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFE38298.1 - 4.1e-22 77.8 0.1 1e-21 76.6 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF2938 PF11158.3 EFE38298.1 - 0.16 11.3 0.0 0.35 10.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2938) Serpin PF00079.15 EFE38299.1 - 6.8e-55 186.6 0.0 8.7e-55 186.3 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AA_permease_2 PF13520.1 EFE38300.1 - 2.7e-51 174.4 53.3 3.2e-51 174.2 36.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE38300.1 - 1.5e-21 76.3 39.8 2e-21 75.9 27.6 1.1 1 0 0 1 1 1 1 Amino acid permease GST_N_2 PF13409.1 EFE38301.1 - 4.6e-11 42.5 0.0 1.1e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 EFE38301.1 - 8.5e-11 41.9 0.0 1.9e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE38301.1 - 1.2e-05 25.0 0.1 4.7e-05 23.1 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE38301.1 - 0.0089 16.4 0.0 0.019 15.4 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFE38301.1 - 0.014 15.3 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ABC_tran PF00005.22 EFE38302.1 - 6.1e-45 152.8 0.1 2.2e-24 86.3 0.0 4.1 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFE38302.1 - 1.1e-15 58.3 0.0 0.0073 16.3 0.0 4.2 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 EFE38302.1 - 3.5e-11 42.7 0.1 0.0011 18.2 0.0 4.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.18 EFE38302.1 - 3.2e-07 30.2 0.0 0.047 13.6 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase Chromo PF00385.19 EFE38302.1 - 9.7e-07 28.3 0.1 2.1e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF258 PF03193.11 EFE38302.1 - 1.1e-06 27.9 0.0 0.02 14.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.1 EFE38302.1 - 2.4e-06 26.9 1.8 0.04 13.4 0.6 2.7 2 1 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.1 EFE38302.1 - 2.8e-06 26.6 0.0 0.12 11.3 0.0 3.3 3 0 0 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 EFE38302.1 - 3.4e-06 27.8 0.1 0.099 13.4 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_23 PF13476.1 EFE38302.1 - 6.5e-06 26.6 1.2 0.017 15.4 0.0 3.1 3 0 0 3 3 3 2 AAA domain Miro PF08477.8 EFE38302.1 - 1e-05 25.9 0.0 0.029 14.8 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein SbcCD_C PF13558.1 EFE38302.1 - 2.2e-05 24.2 0.0 0.41 10.5 0.0 3.2 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 EFE38302.1 - 3.4e-05 23.9 0.1 0.17 12.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EFE38302.1 - 3.6e-05 23.3 3.4 0.3 10.5 0.2 4.0 4 0 0 4 4 4 2 AAA-like domain HEAT PF02985.17 EFE38302.1 - 3.8e-05 23.3 0.5 0.14 12.3 0.4 4.9 5 0 0 5 5 5 1 HEAT repeat NACHT PF05729.7 EFE38302.1 - 9.2e-05 22.1 1.0 0.082 12.5 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_28 PF13521.1 EFE38302.1 - 0.00046 20.1 0.0 0.019 14.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 EFE38302.1 - 0.00079 19.3 3.3 0.057 13.2 0.1 3.4 4 0 0 4 4 2 1 Domain of unknown function DUF87 HEAT_2 PF13646.1 EFE38302.1 - 0.0012 19.1 3.4 2.2 8.6 0.0 4.1 2 2 2 4 4 4 1 HEAT repeats MobB PF03205.9 EFE38302.1 - 0.0012 18.5 0.0 1 9.0 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 EFE38302.1 - 0.0015 18.7 0.1 1.5 9.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.1 EFE38302.1 - 0.0066 16.7 0.6 2.3 8.5 0.0 3.2 3 0 0 3 3 2 1 AAA domain DUF1666 PF07891.7 EFE38302.1 - 0.012 15.0 0.1 0.22 10.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1666) AAA_14 PF13173.1 EFE38302.1 - 0.012 15.4 0.0 5.9 6.8 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.1 EFE38302.1 - 0.017 14.5 0.0 5.9 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 EFE38302.1 - 0.019 13.7 0.3 5.2 5.7 0.0 2.4 2 0 0 2 2 2 0 ArgK protein AAA PF00004.24 EFE38302.1 - 0.024 14.8 0.1 2 8.6 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.4 EFE38302.1 - 0.025 14.0 0.1 0.96 8.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP-synt_ab PF00006.20 EFE38302.1 - 0.026 14.0 0.0 5.4 6.4 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_13 PF13166.1 EFE38302.1 - 0.058 11.8 0.1 3.9 5.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.3 EFE38302.1 - 0.059 10.7 2.8 0.82 6.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_33 PF13671.1 EFE38302.1 - 0.084 12.7 0.0 12 5.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EFE38302.1 - 0.21 10.4 1.9 2 7.1 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.1 EFE38302.1 - 0.24 10.9 3.8 3.1 7.3 0.2 3.2 3 0 0 3 3 3 0 AAA domain Glyco_hydro_92 PF07971.7 EFE38303.1 - 1.4e-169 565.0 0.3 1.8e-169 564.6 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Citrate_synt PF00285.16 EFE38304.1 - 5.5e-101 337.8 0.0 6.4e-101 337.6 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase ICL PF00463.16 EFE38305.1 - 6.3e-197 654.9 0.1 7.3e-197 654.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 EFE38305.1 - 1.1e-11 44.4 0.0 2.9e-10 39.7 0.0 2.2 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase AMP-binding PF00501.23 EFE38306.1 - 7.6e-71 238.6 0.0 9.3e-71 238.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE38306.1 - 7.7e-10 39.5 0.1 1.9e-09 38.3 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1661 PF07877.6 EFE38306.1 - 0.12 11.9 0.4 0.28 10.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1661) MmgE_PrpD PF03972.9 EFE38307.1 - 1.9e-149 497.6 0.0 2.1e-149 497.4 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family NPBW PF15180.1 EFE38308.1 - 0.13 11.9 0.2 0.13 11.9 0.1 1.7 2 0 0 2 2 2 0 Neuropeptides B and W DNA_methylase PF00145.12 EFE38309.1 - 2.8e-41 141.7 0.0 4.1e-31 108.3 0.0 2.1 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase GATase_2 PF00310.16 EFE38310.1 - 1.1e-18 67.1 0.0 2.6e-14 52.7 0.0 2.7 3 0 0 3 3 3 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EFE38310.1 - 8.8e-14 51.5 0.0 2.1e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EFE38310.1 - 3.3e-13 49.4 0.0 8e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 EFE38310.1 - 1.1e-11 44.5 0.2 2.6e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 EFE38310.1 - 2.2e-06 26.5 0.0 4.1e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II HhH-GPD PF00730.20 EFE38311.1 - 9.9e-10 38.6 0.0 2.2e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Aldedh PF00171.17 EFE38312.1 - 4.1e-118 394.6 0.0 7.3e-118 393.8 0.0 1.3 1 1 0 1 1 1 1 Aldehyde dehydrogenase family DUF2992 PF11208.3 EFE38313.1 - 0.011 15.5 3.0 0.025 14.4 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Pkinase PF00069.20 EFE38314.1 - 3.3e-36 124.7 0.0 6.9e-36 123.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38314.1 - 6.3e-23 81.1 0.0 1.1e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE38314.1 - 0.00036 20.3 0.0 0.0024 17.6 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EFE38314.1 - 0.0075 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFE38314.1 - 0.0089 15.1 0.1 0.018 14.1 0.1 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 EFE38314.1 - 0.078 12.3 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Mt_ATP-synt_D PF05873.7 EFE38316.1 - 8.3e-16 58.0 1.0 1.2e-15 57.4 0.7 1.2 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) EzrA PF06160.7 EFE38316.1 - 0.02 13.1 2.5 0.027 12.6 1.8 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA T2SM_b PF10741.4 EFE38316.1 - 0.18 11.4 1.0 1.6 8.4 0.0 2.6 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein M subtype b Tropomyosin_1 PF12718.2 EFE38316.1 - 0.92 9.3 6.4 3.9 7.2 1.1 2.5 1 1 0 2 2 2 0 Tropomyosin like NAC PF01849.13 EFE38317.1 - 4.5e-24 83.7 0.0 5.5e-23 80.2 0.0 2.2 2 0 0 2 2 2 1 NAC domain UBA PF00627.26 EFE38317.1 - 0.00019 21.1 0.5 0.00037 20.2 0.3 1.6 1 0 0 1 1 1 1 UBA/TS-N domain SpoIIIAH PF12685.2 EFE38317.1 - 0.48 9.9 11.0 0.2 11.1 5.5 1.7 2 0 0 2 2 2 0 SpoIIIAH-like protein CENP-B_dimeris PF09026.5 EFE38317.1 - 0.65 10.2 5.4 10 6.4 2.5 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ribosomal_L14e PF01929.12 EFE38318.1 - 2.3e-27 95.1 1.3 3.1e-27 94.7 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 EFE38318.1 - 8.3e-07 28.4 0.1 1.4e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 KOW motif MFS_1 PF07690.11 EFE38319.1 - 7.8e-38 130.0 19.5 1.5e-24 86.3 3.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE38319.1 - 3.9e-12 45.4 5.3 3.9e-12 45.4 3.7 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.1 EFE38319.1 - 2e-11 42.9 0.5 7.1e-06 24.6 0.4 3.6 1 1 3 4 4 4 3 MFS/sugar transport protein Folate_carrier PF01770.13 EFE38319.1 - 0.00034 19.2 0.0 0.00062 18.3 0.0 1.3 1 0 0 1 1 1 1 Reduced folate carrier MFS_1_like PF12832.2 EFE38319.1 - 0.001 18.8 4.3 0.055 13.2 0.1 3.4 3 1 0 3 3 3 2 MFS_1 like family LacY_symp PF01306.14 EFE38319.1 - 0.0039 15.7 3.2 0.12 10.9 0.0 2.3 2 1 0 2 2 2 2 LacY proton/sugar symporter MFS_3 PF05977.8 EFE38319.1 - 1.2 7.2 7.8 0.18 9.8 0.8 2.6 2 2 0 3 3 3 0 Transmembrane secretion effector SRP-alpha_N PF04086.8 EFE38320.1 - 5.5e-76 255.5 0.0 7.7e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.17 EFE38320.1 - 1.8e-50 171.1 0.0 3e-50 170.3 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain CbiA PF01656.18 EFE38320.1 - 1.8e-06 27.4 0.1 4.2e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54_N PF02881.14 EFE38320.1 - 3.3e-06 27.0 2.1 4.4e-06 26.6 0.1 2.3 2 1 0 2 2 2 1 SRP54-type protein, helical bundle domain ArgK PF03308.11 EFE38320.1 - 5.7e-06 25.3 0.0 1.1e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 ArgK protein AAA_16 PF13191.1 EFE38320.1 - 0.00059 19.8 0.1 0.0034 17.3 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.1 EFE38320.1 - 0.00094 18.8 0.0 0.0021 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 EFE38320.1 - 0.0044 16.7 0.1 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 EFE38320.1 - 0.024 14.6 0.1 0.099 12.6 0.0 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase Fer4_NifH PF00142.13 EFE38320.1 - 0.044 12.9 0.0 0.093 11.8 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family YIF1 PF03878.10 EFE38321.1 - 2.5e-73 246.1 4.3 3.1e-73 245.8 3.0 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 EFE38321.1 - 0.0011 18.4 6.5 0.0011 18.4 4.5 1.6 2 0 0 2 2 2 1 Yip1 domain Catalase PF00199.14 EFE38322.1 - 1.9e-158 527.1 3.3 4.4e-157 522.6 2.3 2.0 1 1 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EFE38322.1 - 3.7e-16 58.7 0.0 7e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive DJ-1_PfpI PF01965.19 EFE38322.1 - 0.0045 16.4 0.0 0.009 15.4 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family DUF3548 PF12068.3 EFE38324.1 - 5.6e-11 42.1 0.0 0.0001 21.7 0.0 3.5 3 1 0 3 3 3 3 Domain of unknown function (DUF3548) HEV_ORF1 PF02444.11 EFE38324.1 - 0.089 12.9 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 Hepatitis E virus ORF-2 (Putative capsid protein) RabGAP-TBC PF00566.13 EFE38325.1 - 1.7e-34 119.1 5.2 3.3e-34 118.2 3.6 1.4 1 1 0 1 1 1 1 Rab-GTPase-TBC domain MSA-2c PF12238.3 EFE38325.1 - 0.12 12.0 1.2 0.2 11.2 0.8 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF2360 PF10152.4 EFE38325.1 - 0.9 9.8 5.4 0.24 11.6 1.1 1.8 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) GAS2 PF02187.12 EFE38326.1 - 0.00016 21.3 0.1 0.00037 20.2 0.1 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Hus1 PF04005.7 EFE38327.1 - 1.1e-102 342.9 0.0 2.8e-100 335.0 0.0 2.1 1 1 0 1 1 1 1 Hus1-like protein Sec16_C PF12931.2 EFE38328.1 - 7.2e-107 357.3 0.1 1e-106 356.8 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16_N PF12935.2 EFE38328.1 - 6e-41 140.9 27.6 6e-41 140.9 19.1 4.2 2 1 1 3 3 3 1 Vesicle coat trafficking protein Sec16 N-terminus Sec16 PF12932.2 EFE38328.1 - 1.5e-30 105.5 0.0 3.4e-30 104.4 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region E1-E2_ATPase PF00122.15 EFE38329.1 - 2.7e-17 62.5 0.0 6.6e-17 61.3 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EFE38329.1 - 6e-14 52.9 0.0 2.1e-13 51.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFE38329.1 - 1.1e-10 41.9 0.0 2.5e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE38329.1 - 6.2e-08 32.4 0.0 5.5e-07 29.4 0.0 2.6 3 0 0 3 3 3 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFE38329.1 - 0.0083 15.7 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Mso1_Sec1_bdg PF14475.1 EFE38330.1 - 9.2e-08 31.3 0.0 1.7e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Mak16 PF04874.9 EFE38331.1 - 5.9e-24 84.0 14.4 5.9e-24 84.0 10.0 2.5 2 0 0 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L28e PF01778.12 EFE38331.1 - 1.2e-10 41.8 0.0 2.6e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L28e protein family Nop14 PF04147.7 EFE38331.1 - 0.044 11.7 30.1 0.059 11.2 20.9 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.7 EFE38331.1 - 0.07 11.4 25.7 0.079 11.3 17.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PYC_OADA PF02436.13 EFE38331.1 - 0.1 12.0 0.9 0.25 10.7 0.3 1.8 1 1 1 2 2 2 0 Conserved carboxylase domain SGT1 PF07093.6 EFE38331.1 - 0.13 10.6 10.7 0.16 10.3 7.4 1.2 1 0 0 1 1 1 0 SGT1 protein CENP-T PF15511.1 EFE38331.1 - 0.3 10.2 15.4 0.4 9.8 10.7 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T BUD22 PF09073.5 EFE38331.1 - 5 6.0 29.8 7.8 5.4 20.7 1.3 1 1 0 1 1 1 0 BUD22 zf-B_box PF00643.19 EFE38332.1 - 0.1 12.5 1.5 0.17 11.7 1.0 1.4 1 0 0 1 1 1 0 B-box zinc finger zf-C2H2 PF00096.21 EFE38332.1 - 0.34 11.3 4.2 0.64 10.4 2.9 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE38332.1 - 0.36 11.2 1.6 0.78 10.2 1.1 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger ECH PF00378.15 EFE38333.1 - 2.7e-24 85.6 0.0 3.5e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family D123 PF07065.9 EFE38334.1 - 1e-92 310.4 0.1 3.3e-92 308.7 0.0 1.7 2 0 0 2 2 2 1 D123 Vps51 PF08700.6 EFE38335.1 - 2.2e-14 53.0 0.6 1.3e-13 50.6 0.0 2.7 3 0 0 3 3 3 1 Vps51/Vps67 DUF1640 PF07798.6 EFE38336.1 - 7.6e-11 42.3 6.6 1.9e-10 41.0 4.6 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1640) ALMT PF11744.3 EFE38336.1 - 0.012 14.3 1.9 0.017 13.8 1.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Baculo_PEP_C PF04513.7 EFE38336.1 - 0.69 9.7 5.9 1.3 8.8 4.1 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HEAT_2 PF13646.1 EFE38337.1 - 2.5e-11 43.6 0.3 0.0022 18.2 0.0 7.1 7 0 0 7 7 7 2 HEAT repeats HEAT PF02985.17 EFE38337.1 - 2.2e-07 30.3 8.7 0.93 9.7 0.0 9.6 11 0 0 11 11 11 1 HEAT repeat Vac14_Fab1_bd PF12755.2 EFE38337.1 - 0.00057 20.2 0.0 0.04 14.2 0.0 3.8 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region Arm PF00514.18 EFE38337.1 - 0.063 13.1 1.4 6.8 6.6 0.0 4.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Transcrip_reg PF01709.15 EFE38338.1 - 2.3e-41 141.4 0.1 2.5e-41 141.3 0.1 1.0 1 0 0 1 1 1 1 Transcriptional regulator CENP-I PF07778.6 EFE38339.1 - 4.6e-87 292.3 2.7 6.4e-87 291.8 1.9 1.1 1 0 0 1 1 1 1 Mis6 Sedlin_N PF04628.8 EFE38339.1 - 0.015 15.2 0.0 0.41 10.5 0.0 2.6 3 0 0 3 3 3 0 Sedlin, N-terminal conserved region CBF PF03914.12 EFE38339.1 - 0.074 12.5 1.9 19 4.6 0.0 3.3 3 0 0 3 3 3 0 CBF/Mak21 family DUF4360 PF14273.1 EFE38340.1 - 3.3e-63 212.6 1.5 3.9e-63 212.4 1.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) CLPTM1 PF05602.7 EFE38341.1 - 2.1e-150 501.2 0.3 2.5e-150 501.0 0.2 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) MtN3_slv PF03083.11 EFE38341.1 - 0.24 11.3 3.2 0.15 11.9 0.2 2.1 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange DUF1240 PF06836.7 EFE38341.1 - 2.4 8.4 6.1 0.77 10.0 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) adh_short PF00106.20 EFE38342.1 - 1.1e-09 38.4 0.0 2.3e-09 37.3 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE38342.1 - 0.0015 18.2 0.0 0.0028 17.3 0.0 1.4 1 0 0 1 1 1 1 KR domain ASXH PF13919.1 EFE38343.1 - 4.7e-33 113.8 1.6 2.2e-32 111.7 1.1 2.1 1 1 0 1 1 1 1 Asx homology domain Longin PF13774.1 EFE38344.1 - 5.7e-21 73.8 1.6 2.7e-20 71.6 1.1 2.0 1 1 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 EFE38344.1 - 7.3e-16 57.5 0.5 2.6e-15 55.7 0.0 1.9 2 0 0 2 2 2 1 Synaptobrevin DUF3510 PF12022.3 EFE38344.1 - 0.0034 17.4 1.7 0.19 11.8 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) Bac_small_YrzI PF09501.5 EFE38344.1 - 0.18 11.7 0.5 0.4 10.6 0.4 1.6 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) PilJ PF13675.1 EFE38344.1 - 0.22 11.8 3.0 1 9.6 0.2 2.1 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1664 PF07889.7 EFE38344.1 - 0.34 10.7 2.4 0.31 10.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) E1-E2_ATPase PF00122.15 EFE38344.1 - 0.68 8.9 2.7 6.1 5.7 0.1 2.5 2 1 0 3 3 3 0 E1-E2 ATPase EMP24_GP25L PF01105.19 EFE38344.1 - 1.1 8.9 4.9 1.8 8.2 0.6 2.2 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Elong_Iki1 PF10483.4 EFE38345.1 - 7e-83 278.2 0.0 2.9e-82 276.2 0.0 1.7 1 1 0 1 1 1 1 Elongator subunit Iki1 DUF1777 PF08648.7 EFE38346.1 - 3.7e-22 78.9 0.4 3.7e-22 78.9 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DAO PF01266.19 EFE38347.1 - 8.4e-63 212.4 0.4 1e-62 212.1 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE38347.1 - 1.7e-07 31.1 0.1 5.3e-07 29.5 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFE38347.1 - 2.6e-05 24.2 0.2 0.18 11.6 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFE38347.1 - 0.00037 19.4 0.1 0.0032 16.3 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.9 EFE38347.1 - 0.0011 17.7 0.0 0.1 11.2 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.22 EFE38347.1 - 0.0036 17.6 0.1 0.015 15.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFE38347.1 - 0.0044 16.1 0.1 0.008 15.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 EFE38347.1 - 0.03 14.1 0.1 0.13 11.9 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.17 EFE38347.1 - 0.038 12.8 0.1 3.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Strep_67kDa_ant PF06100.6 EFE38347.1 - 0.041 12.2 0.1 0.056 11.7 0.1 1.1 1 0 0 1 1 1 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family Pyr_redox_3 PF13738.1 EFE38347.1 - 0.082 12.9 0.0 12 5.8 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_63 PF03200.11 EFE38348.1 - 2.3e-230 766.6 0.0 7.2e-178 593.0 4.8 2.9 1 1 1 2 2 2 2 Mannosyl oligosaccharide glucosidase Trehalase PF01204.13 EFE38348.1 - 0.0015 17.2 2.2 0.0043 15.7 1.4 1.8 1 1 0 1 1 1 1 Trehalase DUF3510 PF12022.3 EFE38348.1 - 0.2 11.7 0.0 0.43 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) MMtag PF10159.4 EFE38349.1 - 3e-32 110.4 4.6 3e-32 110.4 3.2 1.9 2 0 0 2 2 2 1 Kinase phosphorylation protein DUF1777 PF08648.7 EFE38349.1 - 0.0079 15.9 0.3 0.016 14.9 0.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF1777) Senescence_reg PF04520.8 EFE38349.1 - 0.043 14.3 1.9 0.28 11.6 1.2 2.3 2 1 0 2 2 2 0 Senescence regulator CRT10 PF08728.5 EFE38350.1 - 3.1e-16 58.5 0.0 1.5e-09 36.5 0.1 2.2 2 0 0 2 2 2 2 CRT10 Acetyltransf_8 PF13523.1 EFE38350.1 - 0.086 12.7 0.2 0.57 10.0 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Daxx PF03344.10 EFE38350.1 - 8.5 4.7 13.7 12 4.2 9.5 1.1 1 0 0 1 1 1 0 Daxx Family DUF3402 PF11882.3 EFE38351.1 - 1.7e-134 448.9 0.0 2.3e-134 448.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.8 EFE38351.1 - 5.4e-83 278.2 0.0 7.8e-83 277.6 0.0 1.2 1 0 0 1 1 1 1 N1221-like protein RWD PF05773.17 EFE38352.1 - 5.3e-20 71.4 0.2 9.6e-20 70.5 0.1 1.4 1 0 0 1 1 1 1 RWD domain IBR PF01485.16 EFE38352.1 - 9.1e-17 60.6 20.3 3.6e-14 52.3 2.2 4.0 3 1 1 4 4 4 2 IBR domain zf-RING_2 PF13639.1 EFE38352.1 - 0.0064 16.2 10.8 0.0064 16.2 7.5 3.6 2 1 1 3 3 3 2 Ring finger domain PAP2 PF01569.16 EFE38353.1 - 1.4e-13 50.6 4.4 1.7e-13 50.3 3.0 1.1 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.9 EFE38353.1 - 0.03 14.0 0.3 4.8 6.9 0.0 2.3 2 1 0 2 2 2 0 Divergent PAP2 family Ldh_2 PF02615.9 EFE38354.1 - 8.4e-105 350.1 0.0 9.5e-105 350.0 0.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase DUF2346 PF09803.4 EFE38355.1 - 3.4e-05 23.6 0.1 6.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2346) RF-1 PF00472.15 EFE38356.1 - 8e-17 61.0 11.0 4.9e-16 58.5 7.6 1.9 1 1 0 1 1 1 1 RF-1 domain CFTR_R PF14396.1 EFE38356.1 - 0.047 13.0 2.3 0.07 12.4 1.6 1.2 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain DUF4407 PF14362.1 EFE38356.1 - 1 8.2 6.3 1.2 7.9 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CAS_CSE1 PF03378.10 EFE38357.1 - 2.1e-114 382.1 0.0 2.4e-114 382.0 0.0 1.0 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus C9orf72-like PF15019.1 EFE38357.1 - 0.091 11.9 0.2 0.52 9.5 0.1 1.9 1 1 1 2 2 2 0 C9orf72-like protein family Cse1 PF08506.5 EFE38358.1 - 2.6e-153 509.9 3.2 3.6e-153 509.5 2.2 1.2 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.10 EFE38358.1 - 4.3e-42 143.9 1.0 1e-41 142.6 0.2 2.0 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.14 EFE38358.1 - 1.4e-15 56.9 0.2 6.9e-15 54.7 0.1 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EFE38358.1 - 0.017 15.0 0.6 1 9.2 0.0 3.5 5 0 0 5 5 5 0 Exportin 1-like protein HEAT PF02985.17 EFE38358.1 - 0.098 12.7 0.4 14 6.0 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat DUF3384 PF11864.3 EFE38359.1 - 4.3e-83 279.3 0.0 8e-83 278.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.10 EFE38359.1 - 3.3e-49 166.8 0.0 5.3e-49 166.1 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.11 EFE38359.1 - 7.9e-29 100.8 0.6 5.8e-27 94.6 0.0 3.0 3 0 0 3 3 3 1 Tuberin PUF PF00806.14 EFE38360.1 - 1.2e-57 188.2 7.0 1.5e-07 30.5 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF2823 PF11034.3 EFE38362.1 - 0.16 12.0 2.8 0.22 11.6 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2823) CIAPIN1 PF05093.8 EFE38362.1 - 0.53 10.3 4.2 0.59 10.2 2.9 1.1 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis FLO_LFY PF01698.11 EFE38362.1 - 3 6.5 10.2 3.3 6.4 7.1 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF2635 PF10948.3 EFE38362.1 - 3.3 7.1 4.9 0.57 9.5 0.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2635) PepSY_TM_2 PF13703.1 EFE38363.1 - 0.073 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM helix Sarcoglycan_2 PF05510.8 EFE38363.1 - 0.097 10.9 0.0 0.12 10.6 0.0 1.1 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Phosphodiest PF01663.17 EFE38364.1 - 2.7e-16 59.8 0.7 4.8e-16 59.0 0.5 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 EFE38364.1 - 1.3e-05 24.7 1.4 2.2e-05 23.9 1.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 EFE38364.1 - 0.00053 19.2 0.1 0.0009 18.5 0.1 1.4 1 0 0 1 1 1 1 Sulfatase DUF2207 PF09972.4 EFE38364.1 - 0.48 8.9 0.0 0.48 8.9 0.0 3.3 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) cwf21 PF08312.7 EFE38365.1 - 1.3e-16 60.1 22.8 5.7e-16 58.0 15.8 2.1 1 1 0 1 1 1 1 cwf21 domain Atg14 PF10186.4 EFE38365.1 - 0.002 17.1 5.6 0.002 17.1 3.9 1.5 2 0 0 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 Fmp27_WPPW PF10359.4 EFE38365.1 - 0.022 13.2 5.5 0.025 13.0 3.8 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF3650 PF12368.3 EFE38365.1 - 0.1 12.1 3.3 0.11 11.9 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3650) RRN3 PF05327.6 EFE38365.1 - 0.43 8.6 3.6 0.58 8.2 2.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Exonuc_VII_L PF02601.10 EFE38365.1 - 1.2 8.2 6.3 1.7 7.7 4.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF342 PF03961.8 EFE38365.1 - 1.7 6.9 9.5 2.6 6.3 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.9 EFE38365.1 - 2.2 7.8 11.4 0.2 11.2 4.5 1.7 2 0 0 2 2 2 0 IncA protein HA2 PF04408.18 EFE38366.1 - 2e-19 69.5 0.0 2e-19 69.5 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE38366.1 - 1.1e-14 53.9 0.0 4.5e-14 52.0 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 EFE38366.1 - 3.2e-12 46.2 0.0 9.2e-12 44.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 EFE38366.1 - 1.4e-09 37.6 0.0 2.2e-07 30.5 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EFE38366.1 - 0.0049 16.7 8.1 0.4 10.4 0.0 3.6 4 0 0 4 4 4 2 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFE38366.1 - 0.014 15.5 0.2 0.067 13.3 0.0 2.2 2 1 0 2 2 2 0 AAA domain T2SE PF00437.15 EFE38366.1 - 0.03 13.2 0.0 0.12 11.2 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 EFE38366.1 - 0.048 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.1 EFE38366.1 - 0.38 11.0 0.0 0.38 11.0 0.0 3.6 3 0 0 3 3 3 0 AAA domain DUF2372 PF10178.4 EFE38367.1 - 0.0034 17.4 0.0 0.031 14.3 0.0 2.1 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2372) DUF35 PF01796.12 EFE38368.1 - 0.086 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 DUF35 OB-fold domain Cohesin_load PF10345.4 EFE38369.1 - 6.3e-155 516.8 3.7 7.9e-155 516.5 2.6 1.0 1 0 0 1 1 1 1 Cohesin loading factor Lactamase_B_4 PF13691.1 EFE38369.1 - 0.033 13.6 0.0 0.085 12.3 0.0 1.7 1 0 0 1 1 1 0 tRNase Z endonuclease NTR2 PF15458.1 EFE38369.1 - 0.061 12.5 0.4 0.14 11.4 0.3 1.5 1 0 0 1 1 1 0 Nineteen complex-related protein 2 DUF3663 PF12404.3 EFE38369.1 - 0.41 10.4 2.7 13 5.6 0.3 2.5 2 0 0 2 2 2 0 Peptidase TPR_4 PF07721.9 EFE38369.1 - 6.3 7.5 8.5 16 6.3 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DER1 PF04511.10 EFE38370.1 - 1.2e-26 93.4 0.0 1.5e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Der1-like family 7TMR-DISM_7TM PF07695.6 EFE38370.1 - 0.33 10.5 8.3 1.3 8.6 5.7 1.8 1 1 0 1 1 1 0 7TM diverse intracellular signalling EMP70 PF02990.11 EFE38371.1 - 2.9e-128 428.5 0.0 1.1e-127 426.7 0.0 1.8 1 1 0 1 1 1 1 Endomembrane protein 70 ubiquitin PF00240.18 EFE38372.1 - 5.7e-18 64.0 0.0 1.1e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.26 EFE38372.1 - 3.6e-09 36.1 0.0 8.9e-09 34.9 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.3 EFE38372.1 - 1.6e-06 27.6 0.0 2.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 EFE38372.1 - 0.00032 20.8 1.1 0.00063 19.8 0.0 1.9 2 1 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 EFE38372.1 - 0.00047 20.0 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like MMS1_N PF10433.4 EFE38373.1 - 1.3e-66 224.7 0.0 1.9e-66 224.2 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term WD40 PF00400.27 EFE38373.1 - 0.16 11.9 1.1 0.53 10.2 0.1 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat CPSF_A PF03178.10 EFE38374.1 - 2.5e-101 338.9 0.0 3e-101 338.7 0.0 1.1 1 0 0 1 1 1 1 CPSF A subunit region CN_hydrolase PF00795.17 EFE38375.1 - 2.8e-21 75.7 0.0 3.8e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase BP28CT PF08146.7 EFE38376.1 - 2.2e-43 147.6 3.2 3.1e-43 147.1 0.3 2.9 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.3 EFE38376.1 - 2.6e-28 98.4 19.5 7.3e-27 93.7 0.7 6.7 8 0 0 8 8 8 2 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.1 EFE38376.1 - 8.8e-09 35.5 6.8 0.11 12.8 0.0 7.3 6 1 0 6 6 6 3 HEAT repeats HEAT_EZ PF13513.1 EFE38376.1 - 0.056 13.9 15.7 0.42 11.1 0.2 7.2 8 1 1 9 9 9 0 HEAT-like repeat HEAT PF02985.17 EFE38376.1 - 0.15 12.2 11.3 1.4 9.2 0.0 6.8 8 0 0 8 8 8 0 HEAT repeat NRDE-2 PF08424.5 EFE38377.1 - 5.3e-87 291.6 0.0 9e-86 287.6 0.0 2.6 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_16 PF13432.1 EFE38377.1 - 0.00045 20.8 0.3 0.11 13.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFE38377.1 - 0.12 12.5 0.6 0.97 9.7 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE38377.1 - 0.55 10.6 4.2 1.3 9.3 0.1 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat UDG PF03167.14 EFE38378.1 - 3e-19 68.9 0.0 7.7e-19 67.6 0.0 1.6 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily CitMHS PF03600.11 EFE38379.1 - 0.073 11.6 0.4 0.11 11.0 0.3 1.2 1 0 0 1 1 1 0 Citrate transporter 7TMR-DISM_7TM PF07695.6 EFE38379.1 - 0.22 11.1 7.7 0.7 9.5 5.4 1.6 1 1 0 1 1 1 0 7TM diverse intracellular signalling NAD_binding_6 PF08030.7 EFE38380.1 - 1.4e-23 83.5 0.0 3e-23 82.4 0.0 1.6 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFE38380.1 - 5e-23 80.9 0.0 1.1e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 EFE38380.1 - 2.4e-17 63.1 11.4 5.4e-17 62.0 7.9 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 EFE38380.1 - 5.2e-05 23.2 0.0 0.00014 21.9 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EFE38380.1 - 0.014 15.9 0.0 3.9 8.1 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain SBDS PF01172.13 EFE38381.1 - 4.6e-28 96.8 0.2 5.3e-28 96.6 0.1 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein XkdN PF08890.6 EFE38381.1 - 0.043 13.5 0.0 0.47 10.2 0.0 2.0 2 0 0 2 2 2 0 Phage XkdN-like protein RhoGEF PF00621.15 EFE38382.1 - 1.6e-20 73.7 0.1 5e-19 68.8 0.0 2.3 1 1 0 1 1 1 1 RhoGEF domain CytochromB561_N PF09786.4 EFE38383.1 - 0.15 10.5 0.2 0.19 10.1 0.1 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal Ni_hydr_CYTB PF01292.15 EFE38383.1 - 0.39 10.0 7.7 0.094 12.0 1.3 2.0 1 1 0 2 2 2 0 Prokaryotic cytochrome b561 Methyltransf_23 PF13489.1 EFE38385.1 - 0.0075 16.0 0.0 0.0075 16.0 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain IFRD PF05004.8 EFE38386.1 - 7.7e-31 107.3 5.7 9.8e-31 106.9 4.0 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) ORC6 PF05460.8 EFE38386.1 - 0.47 9.4 8.7 0.045 12.8 2.3 1.9 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Corona_nucleoca PF00937.13 EFE38386.1 - 1.1 8.1 9.3 1.8 7.4 6.4 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Rep_4 PF05797.6 EFE38386.1 - 1.4 7.5 7.7 0.8 8.3 0.6 2.2 2 0 0 2 2 2 0 Yeast trans-acting factor (REP1/REP2) Pkinase PF00069.20 EFE38387.1 - 1.4e-59 201.3 0.0 1.9e-59 200.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38387.1 - 7.8e-35 120.1 0.0 1.1e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE38387.1 - 0.0013 17.7 0.0 0.0025 16.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EFE38387.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 EFE38387.1 - 0.16 11.6 0.0 0.46 10.1 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family SH2_2 PF14633.1 EFE38388.1 - 3.6e-85 284.5 0.0 3.6e-85 284.5 0.0 3.1 3 0 0 3 3 3 1 SH2 domain DLD PF14878.1 EFE38388.1 - 2.2e-35 121.2 5.3 2.2e-35 121.2 3.7 3.5 2 0 0 2 2 2 1 Death-like domain of SPT6 HHH_7 PF14635.1 EFE38388.1 - 8.7e-28 96.4 0.0 2e-27 95.3 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.1 EFE38388.1 - 3.3e-27 94.8 0.0 1.2e-26 93.1 0.0 2.0 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.1 EFE38388.1 - 7e-24 83.8 22.4 7e-24 83.8 15.5 6.0 7 0 0 7 7 7 1 Acidic N-terminal SPT6 HTH_44 PF14641.1 EFE38388.1 - 1.5e-17 63.6 4.0 1.5e-17 63.6 2.8 3.4 2 1 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_3 PF12836.2 EFE38388.1 - 8.2e-05 22.4 0.0 0.00032 20.5 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif SH2 PF00017.19 EFE38388.1 - 0.00033 20.3 0.1 0.0018 18.0 0.0 2.3 2 0 0 2 2 2 1 SH2 domain Acetyltransf_3 PF13302.1 EFE38389.1 - 2.6e-25 89.2 0.0 4.3e-25 88.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE38389.1 - 0.00014 21.8 0.0 0.002 18.1 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFE38389.1 - 0.06 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein DUF4414 PF14377.1 EFE38390.1 - 1.8 8.5 9.1 2.7 7.9 1.7 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4414) TBPIP PF07106.8 EFE38391.1 - 1.4e-10 40.9 5.3 1.6e-10 40.7 3.7 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Transposase_22 PF02994.9 EFE38391.1 - 0.0039 15.7 2.8 0.0047 15.4 1.9 1.1 1 0 0 1 1 1 1 L1 transposable element DUF4140 PF13600.1 EFE38391.1 - 0.005 17.2 4.8 0.0054 17.1 0.6 2.2 2 0 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) Flexi_CP PF00286.15 EFE38391.1 - 0.017 14.8 0.9 0.13 11.9 0.2 2.0 1 1 1 2 2 2 0 Viral coat protein DUF3573 PF12097.3 EFE38391.1 - 0.061 11.9 1.5 0.07 11.7 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) FlxA PF14282.1 EFE38391.1 - 0.072 13.0 5.9 0.14 12.1 4.1 1.5 1 1 0 1 1 1 0 FlxA-like protein DUF3373 PF11853.3 EFE38391.1 - 0.1 11.1 3.2 0.14 10.6 2.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) IncA PF04156.9 EFE38391.1 - 0.14 11.6 6.7 0.16 11.5 4.6 1.2 1 0 0 1 1 1 0 IncA protein DNA_photolyase PF00875.13 EFE38391.1 - 0.15 11.8 1.3 0.34 10.6 0.9 1.7 1 1 0 1 1 1 0 DNA photolyase PspA_IM30 PF04012.7 EFE38391.1 - 0.2 10.9 7.9 0.053 12.8 2.1 1.9 1 1 1 2 2 2 0 PspA/IM30 family Ax_dynein_light PF10211.4 EFE38391.1 - 0.29 10.9 5.9 1.9 8.3 0.3 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain Phage_GP20 PF06810.6 EFE38391.1 - 0.44 9.9 3.9 0.91 8.9 2.7 1.5 1 1 0 1 1 1 0 Phage minor structural protein GP20 DivIVA PF05103.8 EFE38391.1 - 0.52 10.3 5.9 0.45 10.5 0.8 2.1 1 1 1 2 2 2 0 DivIVA protein Viral_P18 PF04521.8 EFE38391.1 - 0.54 9.7 8.6 0.21 11.0 0.6 2.4 2 1 1 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein DUF972 PF06156.8 EFE38391.1 - 1.4 9.2 5.7 9.9 6.5 3.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Prominin PF05478.6 EFE38391.1 - 1.6 6.1 5.5 2.1 5.7 3.8 1.2 1 1 0 1 1 1 0 Prominin Sel1 PF08238.7 EFE38393.1 - 3.5e-18 65.6 16.1 5.2e-08 33.2 0.1 6.5 6 0 0 6 6 6 4 Sel1 repeat TPR_11 PF13414.1 EFE38393.1 - 0.057 13.0 0.1 0.057 13.0 0.1 2.4 3 0 0 3 3 3 0 TPR repeat DUF1959 PF09218.5 EFE38393.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) Mt_ATP-synt_B PF05405.9 EFE38393.1 - 0.18 11.2 0.4 0.35 10.2 0.3 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) TPR_1 PF00515.23 EFE38393.1 - 0.41 10.3 2.8 0.7 9.6 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Helicase_C_2 PF13307.1 EFE38394.1 - 6.8e-55 185.5 0.0 3.8e-54 183.1 0.0 2.1 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.10 EFE38394.1 - 5.6e-43 146.3 0.5 4.4e-42 143.4 0.4 2.1 1 1 0 1 1 1 1 DEAD_2 DEAD PF00270.24 EFE38394.1 - 0.0009 18.7 0.0 0.48 9.9 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 EFE38394.1 - 0.0071 16.1 0.0 5.3 6.8 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFE38394.1 - 0.025 14.7 1.8 0.79 9.8 0.2 3.1 2 1 0 2 2 2 0 AAA domain Ribosomal_L18e PF00828.14 EFE38395.1 - 5.4e-36 123.8 0.0 6.1e-36 123.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Abhydrolase_6 PF12697.2 EFE38396.1 - 1.8e-07 31.3 0.0 2.4e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE38396.1 - 5.3e-06 26.2 0.0 8.2e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFE38396.1 - 0.016 14.4 0.0 2.5 7.2 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family PLDc PF00614.17 EFE38397.1 - 2.7e-17 61.9 1.0 2.3e-08 33.5 0.2 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 EFE38397.1 - 3e-12 46.3 0.0 1.7e-07 31.0 0.0 2.8 2 0 0 2 2 2 2 PLD-like domain PX PF00787.19 EFE38397.1 - 2.8e-10 40.0 0.3 8.4e-10 38.4 0.2 1.9 1 0 0 1 1 1 1 PX domain AA_permease PF00324.16 EFE38398.1 - 1.7e-45 155.2 21.4 1.2e-39 136.0 13.4 2.4 2 1 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.1 EFE38398.1 - 1.7e-19 69.6 19.2 1.4e-18 66.6 13.5 2.0 1 1 1 2 2 2 1 Amino acid permease PH_7 PF15408.1 EFE38399.1 - 0.044 13.6 0.1 0.098 12.5 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Methyltransf_31 PF13847.1 EFE38400.1 - 1.1e-29 102.9 0.1 1.7e-29 102.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38400.1 - 1.5e-16 60.6 0.3 8.1e-16 58.2 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE38400.1 - 9.9e-16 57.5 0.2 2.1e-15 56.4 0.1 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 EFE38400.1 - 2.2e-13 50.7 0.1 5e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38400.1 - 3.1e-13 49.9 0.1 8.8e-13 48.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38400.1 - 5.8e-11 42.3 0.0 1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EFE38400.1 - 1.1e-09 38.1 0.0 2.3e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 EFE38400.1 - 4.9e-09 36.2 0.0 1.1e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38400.1 - 9.5e-08 32.4 0.0 1.7e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFE38400.1 - 3.6e-07 29.6 0.5 6.4e-07 28.7 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EFE38400.1 - 1.1e-06 28.0 0.1 2.4e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 EFE38400.1 - 6.2e-05 22.6 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFE38400.1 - 7.6e-05 21.9 0.0 0.00011 21.4 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase UPF0020 PF01170.13 EFE38400.1 - 0.00098 18.7 0.1 0.0017 17.9 0.1 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_3 PF01596.12 EFE38400.1 - 0.0011 18.0 0.1 0.0046 16.0 0.1 1.9 1 1 0 1 1 1 1 O-methyltransferase DOT1 PF08123.8 EFE38400.1 - 0.0012 18.1 1.6 0.002 17.4 0.4 1.9 2 1 0 2 2 2 1 Histone methylation protein DOT1 ADH_zinc_N PF00107.21 EFE38400.1 - 0.011 15.2 0.1 0.16 11.5 0.0 2.7 1 1 1 2 2 2 0 Zinc-binding dehydrogenase Methyltransf_4 PF02390.12 EFE38400.1 - 0.038 13.0 0.1 0.081 11.9 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_15 PF09445.5 EFE38400.1 - 0.046 13.2 0.1 0.065 12.7 0.1 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase GCD14 PF08704.5 EFE38400.1 - 0.11 11.9 0.0 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit CmcI PF04989.7 EFE38400.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Cephalosporin hydroxylase bZIP_1 PF00170.16 EFE38401.1 - 0.038 13.9 6.8 0.056 13.4 4.4 1.5 1 1 0 1 1 1 0 bZIP transcription factor Snf7 PF03357.16 EFE38401.1 - 0.061 12.7 0.5 0.092 12.1 0.3 1.2 1 0 0 1 1 1 0 Snf7 RNF111_N PF15303.1 EFE38401.1 - 0.077 12.5 2.5 0.14 11.6 1.8 1.4 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus CCDC32 PF14989.1 EFE38401.1 - 0.14 11.9 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing 32 bZIP_2 PF07716.10 EFE38401.1 - 0.51 10.2 7.3 1.3 8.8 5.1 1.7 1 1 0 1 1 1 0 Basic region leucine zipper Methyltransf_23 PF13489.1 EFE38402.1 - 5.4e-14 52.2 0.0 5.4e-14 52.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38402.1 - 1e-08 35.5 0.0 2.4e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38402.1 - 9.8e-06 25.2 0.2 4.1e-05 23.1 0.0 2.1 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38402.1 - 1.3e-05 25.5 0.1 5.5e-05 23.5 0.0 2.1 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38402.1 - 0.013 16.0 0.0 0.081 13.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 EFE38402.1 - 0.026 14.5 0.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Ycf1 PF05758.7 EFE38402.1 - 3.1 5.3 4.6 4 5.0 3.2 1.1 1 0 0 1 1 1 0 Ycf1 Na_trans_assoc PF06512.8 EFE38402.1 - 4.1 7.3 8.7 6.4 6.6 6.0 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated GAGA_bind PF06217.7 EFE38402.1 - 4.9 7.0 10.7 6.4 6.6 7.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Daxx PF03344.10 EFE38402.1 - 6.3 5.1 17.5 8.6 4.7 12.2 1.0 1 0 0 1 1 1 0 Daxx Family Ebola_NP PF05505.7 EFE38402.1 - 8.6 4.2 17.1 11 3.9 11.9 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein FAD_binding_3 PF01494.14 EFE38403.1 - 1.3e-18 67.2 1.6 2.2e-13 50.0 0.9 2.8 2 1 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.19 EFE38403.1 - 0.0016 17.5 0.0 0.0096 15.0 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EFE38403.1 - 0.05 13.6 0.1 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain MPC PF03650.8 EFE38404.1 - 2.3e-35 121.1 0.2 3.8e-35 120.4 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) DUF883 PF05957.8 EFE38404.1 - 2.2 8.7 8.8 2.5 8.5 1.8 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Nucleoplasmin PF03066.10 EFE38404.1 - 3.9 6.9 7.2 6.8 6.1 5.0 1.3 1 0 0 1 1 1 0 Nucleoplasmin Sel1 PF08238.7 EFE38405.1 - 2.8e-47 158.1 27.3 4.4e-08 33.4 0.4 7.8 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 EFE38405.1 - 0.12 12.9 6.6 0.78 10.3 0.0 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE38405.1 - 0.22 12.2 5.1 4.3 8.2 0.6 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat Acyl_transf_1 PF00698.16 EFE38406.1 - 1.1e-81 274.6 0.1 6.4e-77 258.9 0.0 4.8 3 2 0 3 3 3 2 Acyl transferase domain MaoC_dehydratas PF01575.14 EFE38406.1 - 8.5e-40 134.9 0.2 4.8e-39 132.5 0.0 2.2 2 0 0 2 2 2 1 MaoC like domain DUF1729 PF08354.5 EFE38406.1 - 1.3e-31 108.1 0.6 3.4e-31 106.7 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 EFE38406.1 - 1.2e-20 73.5 0.0 4.3e-20 71.8 0.0 2.0 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.10 EFE38406.1 - 0.00014 21.0 0.2 0.014 14.5 0.1 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase ketoacyl-synt PF00109.21 EFE38407.1 - 1.5e-19 70.5 0.0 2.8e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain adh_short_C2 PF13561.1 EFE38407.1 - 1.5e-19 70.7 0.0 3.3e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ACPS PF01648.15 EFE38407.1 - 2e-18 66.2 0.1 4.2e-18 65.2 0.1 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 EFE38407.1 - 8.2e-12 45.0 0.0 2e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.20 EFE38407.1 - 9.6e-05 22.3 0.0 0.00021 21.2 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE38407.1 - 0.012 15.2 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 KR domain TRM PF02005.11 EFE38408.1 - 8.4e-108 360.6 0.0 1e-92 310.9 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_26 PF13659.1 EFE38408.1 - 0.0005 20.0 0.1 0.0013 18.7 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38408.1 - 0.00071 19.1 0.0 0.0017 17.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38408.1 - 0.0035 17.9 0.0 0.0066 17.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 EFE38408.1 - 0.045 13.3 0.0 0.077 12.5 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein MTS PF05175.9 EFE38408.1 - 0.12 11.7 0.0 0.32 10.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase small domain Resistin PF06954.6 EFE38408.1 - 0.13 12.5 0.0 2 8.7 0.0 2.8 3 0 0 3 3 3 0 Resistin RRM_1 PF00076.17 EFE38410.1 - 2.2e-13 49.6 0.0 3.7e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE38410.1 - 2.8e-08 33.6 0.0 4.5e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE38410.1 - 4.9e-06 26.2 0.0 7.8e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EFE38410.1 - 0.00032 20.3 0.0 0.00061 19.5 0.0 1.4 1 0 0 1 1 1 1 Limkain b1 Kinesin PF00225.18 EFE38412.1 - 1.5e-86 290.1 1.0 1.5e-86 290.1 0.7 2.4 2 1 0 2 2 2 1 Kinesin motor domain DUF1900 PF08954.6 EFE38413.1 - 8.7e-50 167.7 0.0 7.6e-49 164.7 0.0 2.3 2 1 1 3 3 3 1 Domain of unknown function (DUF1900) WD40 PF00400.27 EFE38413.1 - 6e-17 60.8 0.3 3.1e-06 26.8 0.0 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF1899 PF08953.6 EFE38413.1 - 3e-10 39.5 0.0 6e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) Nup160 PF11715.3 EFE38413.1 - 0.013 13.6 0.2 0.038 12.1 0.1 1.5 1 1 1 2 2 2 0 Nucleoporin Nup120/160 eIF2A PF08662.6 EFE38413.1 - 0.014 15.1 0.2 0.18 11.4 0.0 1.9 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A SlyX PF04102.7 EFE38413.1 - 0.11 12.9 0.3 0.26 11.7 0.2 1.7 1 0 0 1 1 1 0 SlyX CBFD_NFYB_HMF PF00808.18 EFE38415.1 - 4.1e-14 52.3 1.0 6.7e-14 51.6 0.7 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFE38415.1 - 2e-06 27.8 0.3 4e-06 26.8 0.2 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAT1 PF09770.4 EFE38415.1 - 0.045 12.0 49.5 0.052 11.7 34.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 EFE38415.1 - 0.27 11.0 32.2 0.41 10.5 22.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BTB PF00651.26 EFE38416.1 - 4.6e-06 26.5 0.0 8.3e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TraQ PF09679.5 EFE38417.1 - 0.014 15.2 0.5 0.079 12.8 0.0 2.2 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Apt1 PF10351.4 EFE38417.1 - 0.47 9.2 8.4 1.1 8.1 5.8 1.6 1 1 0 1 1 1 0 Golgi-body localisation protein domain Dsh_C PF12316.3 EFE38417.1 - 5.7 7.0 20.9 3 7.9 5.7 2.4 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Peptidase_M20 PF01546.23 EFE38418.1 - 1.3e-22 80.2 0.0 3.2e-22 78.9 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.27 EFE38418.1 - 4.3e-15 54.9 5.4 7.5e-06 25.6 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat M20_dimer PF07687.9 EFE38418.1 - 7.7e-05 22.4 0.0 0.00017 21.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain p450 PF00067.17 EFE38419.1 - 1.4e-69 234.8 0.0 1.8e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF747 PF05346.6 EFE38420.1 - 9.4e-126 419.3 8.2 1.3e-125 418.9 5.7 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family Peptidase_M43 PF05572.8 EFE38422.1 - 5.8e-16 58.4 0.1 9.9e-16 57.7 0.1 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.1 EFE38422.1 - 1.9e-06 28.3 1.4 9.6e-06 26.1 1.0 2.1 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 EFE38422.1 - 3.4e-06 27.1 1.3 8.8e-06 25.7 0.9 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 EFE38422.1 - 7e-05 22.4 1.1 0.0014 18.1 0.2 2.2 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 EFE38422.1 - 0.00041 20.4 4.2 0.0012 18.9 2.7 1.9 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 EFE38422.1 - 0.0066 16.1 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.4 EFE38422.1 - 0.013 14.4 0.1 0.018 13.9 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M57 PF12388.3 EFE38422.1 - 0.13 11.5 1.5 0.29 10.4 0.2 2.1 3 0 0 3 3 3 0 Dual-action HEIGH metallo-peptidase ERG4_ERG24 PF01222.12 EFE38423.1 - 1e-144 482.2 17.7 1.3e-144 481.9 12.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family FAD_binding_4 PF01565.18 EFE38424.1 - 3.3e-14 52.5 1.1 2.6e-12 46.3 0.7 2.3 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE38424.1 - 0.0058 16.5 0.2 0.014 15.3 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF1708 PF08101.6 EFE38426.1 - 1.9e-119 399.2 0.0 2.6e-119 398.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) DUF45 PF01863.12 EFE38426.1 - 0.00085 19.1 1.1 0.0016 18.2 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 DUF1708 PF08101.6 EFE38427.1 - 0.059 12.2 0.0 0.072 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) SRF-TF PF00319.13 EFE38428.1 - 1.4e-23 81.8 0.2 2.2e-23 81.2 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ribosomal_L35Ae PF01247.13 EFE38429.1 - 6.1e-30 102.8 1.8 3.4e-20 71.6 0.2 2.1 1 1 1 2 2 2 2 Ribosomal protein L35Ae DUF1168 PF06658.7 EFE38430.1 - 0.27 10.7 10.4 0.31 10.5 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) SMN PF06003.7 EFE38430.1 - 0.33 10.0 5.4 0.37 9.8 3.7 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) ORC6 PF05460.8 EFE38431.1 - 0.41 9.6 4.9 0.48 9.4 3.4 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SLD3 PF08639.5 EFE38431.1 - 0.86 8.1 6.7 0.97 8.0 4.6 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 Gpi16 PF04113.9 EFE38433.1 - 8.6e-234 776.7 0.0 1.1e-233 776.3 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LUC7 PF03194.10 EFE38434.1 - 2.5e-64 217.2 3.5 3.4e-63 213.5 2.4 1.9 1 1 0 1 1 1 1 LUC7 N_terminus DUF3584 PF12128.3 EFE38434.1 - 0.06 10.6 0.1 0.077 10.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DASH_Duo1 PF08651.5 EFE38434.1 - 0.063 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Duo1 TelA PF05816.6 EFE38434.1 - 0.063 11.9 0.3 0.094 11.3 0.2 1.3 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) AAA_13 PF13166.1 EFE38434.1 - 0.077 11.4 0.5 0.1 11.0 0.4 1.2 1 0 0 1 1 1 0 AAA domain GRP PF07172.6 EFE38434.1 - 0.28 11.6 20.0 0.47 10.9 13.9 1.3 1 0 0 1 1 1 0 Glycine rich protein family TFIIS_M PF07500.9 EFE38435.1 - 3.1e-21 75.5 0.0 6.8e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.8 EFE38435.1 - 1.1e-19 71.0 0.0 2.1e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 SPOC domain PHD PF00628.24 EFE38435.1 - 7.5e-10 38.3 11.3 1.3e-09 37.5 7.9 1.4 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.1 EFE38435.1 - 0.028 14.6 4.8 0.14 12.3 3.4 2.3 1 1 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx PHD_2 PF13831.1 EFE38435.1 - 0.048 12.9 3.9 0.08 12.2 2.7 1.4 1 0 0 1 1 1 0 PHD-finger DUF2458 PF10454.4 EFE38438.1 - 0.0036 17.1 0.1 0.0067 16.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) AKNA PF12443.3 EFE38438.1 - 0.12 12.3 1.0 0.3 11.1 0.7 1.7 1 0 0 1 1 1 0 AT-hook-containing transcription factor DASH_Dam1 PF08653.5 EFE38438.1 - 0.15 11.7 0.1 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Dam1 SPX PF03105.14 EFE38438.1 - 5.6 6.6 13.9 9.3 5.9 9.7 1.4 1 1 0 1 1 1 0 SPX domain FF PF01846.14 EFE38439.1 - 2e-13 50.0 6.2 1.2e-09 37.9 0.0 3.8 3 0 0 3 3 3 3 FF domain BPL_N PF09825.4 EFE38439.1 - 0.053 12.3 4.9 0.093 11.4 3.4 1.3 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Proteasome PF00227.21 EFE38440.1 - 1.5e-60 203.7 0.1 1.8e-60 203.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFE38440.1 - 2.9e-14 52.0 0.4 6.9e-14 50.8 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.9 EFE38440.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit MFS_1 PF07690.11 EFE38441.1 - 1e-45 156.0 65.9 1.5e-45 155.4 43.0 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE38441.1 - 8.1e-17 60.9 15.2 8.1e-17 60.9 10.5 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFE38441.1 - 2.1e-14 52.6 24.6 5.3e-14 51.3 16.8 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PS-DH PF14765.1 EFE38442.1 - 4.9e-57 193.3 0.0 8.4e-57 192.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.21 EFE38442.1 - 5.4e-56 189.8 0.0 1.4e-55 188.5 0.0 1.7 2 0 0 2 2 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 EFE38442.1 - 2.7e-54 183.6 0.5 6.3e-54 182.3 0.4 1.7 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 EFE38442.1 - 7e-44 149.6 4.9 9.3e-44 149.2 1.1 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Beta-lactamase PF00144.19 EFE38442.1 - 4.8e-41 140.8 0.0 8.7e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase Acyl_transf_1 PF00698.16 EFE38442.1 - 9.3e-40 136.9 0.0 3.1e-39 135.1 0.0 1.9 1 1 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 EFE38442.1 - 2.2e-31 108.1 0.3 9.8e-31 106.0 0.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.7 EFE38442.1 - 4.8e-18 65.4 0.0 1.8e-17 63.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.1 EFE38442.1 - 9.4e-13 49.1 0.1 1.2e-11 45.6 0.0 3.0 3 0 0 3 3 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFE38442.1 - 1.3e-12 47.3 0.2 2.9e-11 43.0 0.0 3.1 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.1 EFE38442.1 - 1e-11 44.8 0.0 3.1e-11 43.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38442.1 - 5.8e-11 42.1 0.0 1.5e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38442.1 - 7.7e-11 42.5 0.0 7.5e-10 39.3 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38442.1 - 7.2e-08 32.8 0.0 4e-07 30.4 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38442.1 - 6.9e-06 26.3 0.0 3.4e-05 24.1 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE38442.1 - 3.4e-05 23.0 0.0 9.8e-05 21.5 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.7 EFE38442.1 - 6.8e-05 22.5 0.0 0.00015 21.4 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.20 EFE38442.1 - 0.00059 20.0 0.0 0.0018 18.5 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_26 PF13659.1 EFE38442.1 - 0.00079 19.4 0.0 0.0031 17.5 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.18 EFE38442.1 - 0.006 15.6 0.1 0.015 14.3 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_28 PF02636.12 EFE38442.1 - 0.058 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_16 PF10294.4 EFE38442.1 - 0.065 12.6 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase Sigma70_r4 PF04545.11 EFE38442.1 - 0.16 11.2 0.0 0.5 9.7 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 AIF_C PF14721.1 EFE38443.1 - 0.3 11.3 0.1 0.3 11.3 0.1 2.0 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term IncA PF04156.9 EFE38443.1 - 0.89 9.1 6.6 1.8 8.1 0.9 2.2 2 0 0 2 2 2 0 IncA protein GAS PF13851.1 EFE38443.1 - 1.6 7.8 12.8 0.07 12.3 2.9 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding NUDIX PF00293.23 EFE38444.1 - 4.8e-17 61.8 0.2 7.3e-17 61.2 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain TraI_2 PF07514.6 EFE38444.1 - 0.13 11.0 0.2 0.19 10.4 0.1 1.2 1 0 0 1 1 1 0 Putative helicase RNA_pol_A_bac PF01000.21 EFE38445.1 - 1.4e-30 105.6 0.0 2.2e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EFE38445.1 - 1e-10 40.5 0.0 1.4e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Baculo_PEP_C PF04513.7 EFE38446.1 - 0.05 13.4 4.7 0.78 9.5 0.2 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cytochrom_C PF00034.16 EFE38447.1 - 3e-08 34.3 0.3 5.9e-08 33.4 0.0 1.7 2 1 0 2 2 2 1 Cytochrome c Cytochrome_CBB3 PF13442.1 EFE38447.1 - 1.3e-07 31.6 1.5 7.7e-07 29.1 1.1 2.2 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III CCP_MauG PF03150.9 EFE38447.1 - 0.032 14.5 0.0 0.071 13.4 0.0 1.5 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase Cytochrom_C550 PF14495.1 EFE38447.1 - 0.037 13.4 0.0 0.22 11.0 0.0 2.0 2 0 0 2 2 2 0 Cytochrome c-550 domain DUF793 PF05633.6 EFE38447.1 - 0.061 12.0 0.0 0.082 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF793) Orbi_NS3 PF01616.11 EFE38448.1 - 0.082 11.8 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Orbivirus NS3 RNase_PH PF01138.16 EFE38449.1 - 8.1e-14 52.0 0.1 3.4e-13 50.0 0.1 2.0 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 NIR_SIR_ferr PF03460.12 EFE38450.1 - 0.069 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain Metallophos PF00149.23 EFE38451.1 - 5.2e-06 26.0 0.4 2.9e-05 23.5 0.3 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE38451.1 - 0.003 17.4 0.0 0.0089 15.8 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain dCMP_cyt_deam_1 PF00383.17 EFE38452.1 - 4.2e-09 35.9 0.0 4.3e-08 32.7 0.0 2.3 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 EFE38452.1 - 6.4e-06 25.9 0.1 9e-06 25.4 0.1 1.3 1 1 0 1 1 1 1 APOBEC-like N-terminal domain Gp49 PF05973.9 EFE38452.1 - 0.13 12.3 0.1 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 Phage derived protein Gp49-like (DUF891) Stn1 PF10451.4 EFE38453.1 - 1e-12 47.4 0.2 2.9e-08 32.8 0.0 2.1 2 0 0 2 2 2 2 Telomere regulation protein Stn1 Vma12 PF11712.3 EFE38453.1 - 1.2 8.8 5.7 2.1 8.0 4.0 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2058 PF09831.4 EFE38453.1 - 6.9 6.5 10.6 12 5.7 7.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) SelP_N PF04592.9 EFE38454.1 - 0.58 9.4 10.8 1.1 8.5 7.5 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Abhydrolase_6 PF12697.2 EFE38455.1 - 3e-20 73.0 0.1 4.2e-20 72.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE38455.1 - 1.4e-07 31.3 0.0 2.6e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE38455.1 - 9.5e-07 28.6 0.0 3.6e-06 26.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold F-box-like PF12937.2 EFE38457.1 - 0.0049 16.5 0.1 0.013 15.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like APH PF01636.18 EFE38458.1 - 5.4e-12 45.9 0.0 4.3e-11 43.0 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE38458.1 - 0.15 10.6 0.0 2 6.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Stc1 PF12898.2 EFE38459.1 - 4.1e-22 78.0 10.2 8.9e-22 76.9 7.1 1.6 1 0 0 1 1 1 1 Stc1 domain FBP PF07299.6 EFE38459.1 - 0.77 9.0 4.1 0.29 10.4 0.5 1.8 2 0 0 2 2 2 0 Fibronectin-binding protein (FBP) FAD_binding_2 PF00890.19 EFE38463.1 - 8.4e-63 212.6 0.1 1.3e-62 211.9 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.23 EFE38463.1 - 4e-20 71.4 0.1 5.5e-19 67.7 0.1 2.6 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.19 EFE38463.1 - 0.0016 17.4 0.0 0.0029 16.5 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase MSP1_C PF07462.6 EFE38463.1 - 0.24 9.7 4.4 0.37 9.1 3.0 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus MIP-T3 PF10243.4 EFE38464.1 - 1.1 7.5 27.4 2 6.7 19.0 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 WD40 PF00400.27 EFE38465.1 - 4.1e-12 45.4 7.0 0.16 11.9 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat TFIIF_alpha PF05793.7 EFE38465.1 - 0.45 8.8 3.0 0.74 8.1 2.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MFS_1 PF07690.11 EFE38466.1 - 1.1e-26 93.3 42.4 1.1e-26 93.3 29.4 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Acyl_transf_1 PF00698.16 EFE38467.1 - 5.8e-91 305.1 0.0 9.5e-91 304.4 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.21 EFE38467.1 - 3.8e-79 265.7 0.1 1.2e-78 264.1 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 EFE38467.1 - 8.7e-62 207.9 0.4 1.4e-60 204.0 0.0 2.5 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 EFE38467.1 - 7.2e-50 169.1 4.3 8.9e-50 168.8 0.0 3.1 4 0 0 4 4 4 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFE38467.1 - 4e-42 142.8 0.6 1e-41 141.4 0.4 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFE38467.1 - 4.8e-13 49.1 0.1 8.6e-12 45.1 0.0 2.7 2 0 0 2 2 2 1 Phosphopantetheine attachment site PS-DH PF14765.1 EFE38467.1 - 3.9e-12 45.9 0.0 6.8e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.18 EFE38467.1 - 8.9e-05 21.5 0.6 8.9e-05 21.5 0.4 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Resolvase PF00239.16 EFE38467.1 - 0.16 11.7 0.1 0.57 10.0 0.0 1.9 2 0 0 2 2 2 0 Resolvase, N terminal domain DUF2457 PF10446.4 EFE38468.1 - 0.00086 18.1 7.9 0.0011 17.7 5.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Sigma70_ner PF04546.8 EFE38468.1 - 0.016 14.8 4.7 0.019 14.5 3.2 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.5 EFE38468.1 - 0.016 15.3 10.4 0.023 14.9 7.2 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.7 EFE38468.1 - 0.12 12.0 8.7 0.15 11.7 6.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.1 EFE38468.1 - 0.13 12.5 11.3 0.26 11.6 7.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SDA1 PF05285.7 EFE38468.1 - 0.15 11.3 2.4 0.17 11.1 1.7 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.7 EFE38468.1 - 0.15 9.9 2.9 0.17 9.7 2.0 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 EFE38468.1 - 0.17 9.8 1.7 0.19 9.7 1.2 1.1 1 0 0 1 1 1 0 CDC45-like protein GCIP PF13324.1 EFE38468.1 - 0.32 10.1 1.4 0.36 10.0 0.9 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Pap_E4 PF02711.9 EFE38468.1 - 0.39 11.5 5.6 0.67 10.8 3.8 1.5 1 0 0 1 1 1 0 E4 protein Tom22 PF04281.8 EFE38468.1 - 0.49 9.9 5.7 5.4 6.5 4.2 2.0 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 Daxx PF03344.10 EFE38468.1 - 0.53 8.7 6.0 0.61 8.5 4.2 1.1 1 0 0 1 1 1 0 Daxx Family FAM176 PF14851.1 EFE38468.1 - 0.58 9.8 3.3 0.86 9.2 2.3 1.3 1 0 0 1 1 1 0 FAM176 family ANAPC15 PF15243.1 EFE38468.1 - 1.7 8.7 10.0 2.7 8.1 6.9 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Sporozoite_P67 PF05642.6 EFE38468.1 - 1.8 6.3 4.0 2.1 6.1 2.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4611 PF15387.1 EFE38468.1 - 2.1 8.5 12.0 4.7 7.4 8.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Nucleoplasmin PF03066.10 EFE38468.1 - 2.2 7.7 12.7 3.3 7.2 8.8 1.2 1 0 0 1 1 1 0 Nucleoplasmin Neisseria_TspB PF05616.8 EFE38468.1 - 2.7 6.2 13.1 2.4 6.4 9.1 1.0 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF3245 PF11595.3 EFE38468.1 - 3.3 7.9 7.7 5.8 7.1 5.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) BNIP3 PF06553.7 EFE38468.1 - 7.1 5.9 6.7 10 5.4 4.7 1.2 1 0 0 1 1 1 0 BNIP3 CENP-T PF15511.1 EFE38468.1 - 9.2 5.3 16.6 16 4.6 11.5 1.4 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T RasGEF PF00617.14 EFE38469.1 - 9.6e-64 214.5 0.0 1.7e-63 213.7 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EFE38469.1 - 3.6e-25 88.0 0.1 7.9e-25 86.9 0.1 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.23 EFE38469.1 - 1.7e-09 36.9 0.5 3.2e-09 36.0 0.4 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE38469.1 - 3.6e-08 32.8 0.3 8.7e-08 31.6 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFE38469.1 - 9.3e-08 31.4 0.1 2.4e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.21 EFE38469.1 - 3.7e-05 23.4 0.3 0.0027 17.5 0.0 2.6 2 0 0 2 2 2 1 WW domain RHH_1 PF01402.16 EFE38469.1 - 0.26 11.2 2.0 0.4 10.6 0.1 2.4 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family SH3_1 PF00018.23 EFE38470.1 - 3.2e-11 42.4 0.0 6e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE38470.1 - 1.1e-10 40.9 0.0 1.9e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFE38470.1 - 1e-07 31.2 0.0 1.9e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain ENTH PF01417.15 EFE38471.1 - 2e-06 27.6 0.2 4.4e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 ENTH domain RasGAP_C PF03836.10 EFE38472.1 - 8.8e-48 161.6 4.5 2.8e-47 159.9 3.1 2.0 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.14 EFE38472.1 - 1.4e-41 142.3 0.0 3.4e-41 141.0 0.0 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CH PF00307.26 EFE38472.1 - 1.6e-12 47.4 0.0 6e-12 45.5 0.0 2.1 1 0 0 1 1 1 1 Calponin homology (CH) domain IQ PF00612.22 EFE38472.1 - 1.1e-09 36.9 44.9 0.21 11.3 0.0 15.2 16 1 1 17 17 17 5 IQ calmodulin-binding motif IMPDH PF00478.20 EFE38473.1 - 1.8e-130 434.9 3.5 2.2e-130 434.6 2.5 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 EFE38473.1 - 1.7e-18 66.1 0.1 4.1e-10 39.2 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.13 EFE38473.1 - 6.7e-08 31.7 0.7 1.6e-07 30.5 0.5 1.6 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.10 EFE38473.1 - 1.5e-06 27.6 9.3 0.0018 17.5 5.7 2.6 2 1 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.16 EFE38473.1 - 8.8e-05 21.8 1.9 0.00022 20.5 1.3 1.6 1 1 0 1 1 1 1 Histidine biosynthesis protein PK PF00224.16 EFE38473.1 - 0.0015 17.2 0.0 0.0033 16.1 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain Aldolase PF01081.14 EFE38473.1 - 0.011 14.9 1.7 0.044 12.9 0.2 2.3 2 0 0 2 2 2 0 KDPG and KHG aldolase EAL PF00563.15 EFE38473.1 - 0.013 14.9 0.2 2.3 7.6 0.0 2.4 2 0 0 2 2 2 0 EAL domain ThiG PF05690.9 EFE38473.1 - 0.029 13.4 1.9 0.038 13.0 0.5 1.8 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG DUF1273 PF06908.6 EFE38473.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1273) DHO_dh PF01180.16 EFE38473.1 - 0.86 8.4 4.7 0.62 8.9 0.2 2.4 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Ribosomal_S21e PF01249.13 EFE38475.1 - 4.3e-29 100.2 0.2 8.8e-29 99.2 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S21e tRNA-synt_2d PF01409.15 EFE38476.1 - 1.7e-88 296.0 0.0 2.3e-88 295.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 EFE38476.1 - 3.6e-06 25.9 0.5 0.0003 19.6 0.0 3.2 4 0 0 4 4 4 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 EFE38476.1 - 0.0011 18.5 0.0 0.0073 15.9 0.0 2.2 1 1 1 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Fez1 PF06818.10 EFE38477.1 - 0.00046 20.2 0.0 0.00069 19.7 0.0 1.3 1 0 0 1 1 1 1 Fez1 Kdo PF06293.9 EFE38478.1 - 3.8e-05 22.8 0.1 8.1e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE38478.1 - 0.0012 18.5 0.1 0.0012 18.5 0.1 2.9 3 1 1 4 4 4 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFE38478.1 - 0.057 12.7 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.20 EFE38478.1 - 0.087 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DUF3886 PF13025.1 EFE38478.1 - 0.66 9.9 9.9 2 8.4 6.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Autophagy_N PF03986.8 EFE38479.1 - 3.5e-47 159.8 0.1 3.5e-47 159.8 0.0 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 EFE38479.1 - 4.2e-22 78.0 0.2 7.8e-22 77.2 0.1 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 EFE38479.1 - 2.1e-14 52.2 0.5 3.5e-14 51.5 0.3 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal BUD22 PF09073.5 EFE38479.1 - 0.06 12.4 7.6 0.45 9.5 0.1 2.0 2 0 0 2 2 2 0 BUD22 CENP-B_dimeris PF09026.5 EFE38479.1 - 0.11 12.7 7.9 0.27 11.4 2.1 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TFIIB PF00382.14 EFE38480.1 - 0.0079 15.9 0.0 0.041 13.6 0.0 2.1 2 1 0 2 2 2 1 Transcription factor TFIIB repeat 7TM_GPCR_Sru PF10322.4 EFE38480.1 - 0.091 11.8 0.2 0.14 11.2 0.2 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sru EST1_DNA_bind PF10373.4 EFE38481.1 - 3.9e-12 45.9 2.7 7.2e-11 41.8 1.9 2.4 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain Sel1 PF08238.7 EFE38481.1 - 0.19 12.4 1.2 0.35 11.5 0.3 1.9 2 0 0 2 2 2 0 Sel1 repeat TFIIA PF03153.8 EFE38481.1 - 0.29 10.9 27.3 0.16 11.8 11.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Herpes_BLLF1 PF05109.8 EFE38481.1 - 1.2 7.0 7.7 1.8 6.4 5.4 1.2 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Daxx PF03344.10 EFE38482.1 - 0.068 11.6 11.2 0.11 10.9 7.7 1.4 1 0 0 1 1 1 0 Daxx Family eIF-3c_N PF05470.7 EFE38482.1 - 0.69 7.9 5.3 1.2 7.1 3.7 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CobT PF06213.7 EFE38482.1 - 1.7 7.7 13.9 2.7 7.0 9.6 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.9 EFE38482.1 - 5 5.0 11.6 7.5 4.4 8.0 1.2 1 0 0 1 1 1 0 CDC45-like protein NUDIX PF00293.23 EFE38483.1 - 3.9e-09 36.2 0.0 6.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.23 EFE38484.1 - 1.4e-16 60.3 0.0 1.7e-16 60.0 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain KH_1 PF00013.24 EFE38485.1 - 8.2e-39 131.0 9.8 1.8e-15 56.3 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EFE38485.1 - 2.4e-29 100.4 11.1 1.4e-11 43.7 0.8 3.5 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EFE38485.1 - 3e-10 39.5 8.3 0.00048 19.6 0.2 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EFE38485.1 - 7e-09 35.2 2.7 0.056 13.0 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 EFE38485.1 - 0.0012 18.6 4.1 0.93 9.3 0.0 3.3 3 0 0 3 3 3 2 NusA-like KH domain dUTPase PF00692.14 EFE38485.1 - 0.017 14.5 0.3 3.4 7.1 0.0 3.1 3 0 0 3 3 3 0 dUTPase Epimerase PF01370.16 EFE38486.1 - 1.1e-18 67.5 0.0 1.7e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFE38486.1 - 1e-14 53.9 0.0 1.4e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFE38486.1 - 4.4e-10 38.9 0.0 8.1e-10 38.0 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EFE38486.1 - 2.6e-09 37.2 0.0 4.3e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EFE38486.1 - 3.7e-09 36.8 0.7 2.4e-08 34.2 0.5 2.2 1 1 1 2 2 2 1 NADH(P)-binding KR PF08659.5 EFE38486.1 - 2.5e-07 30.5 0.0 4e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EFE38486.1 - 0.0012 17.8 0.0 0.0016 17.3 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 EFE38486.1 - 0.0057 15.9 0.5 0.014 14.6 0.3 2.0 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 EFE38486.1 - 0.053 12.3 0.0 0.075 11.9 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain DSBA PF01323.15 EFE38487.1 - 8.5e-24 84.1 0.0 9.3e-24 84.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.1 EFE38487.1 - 0.017 15.1 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Pkinase PF00069.20 EFE38488.1 - 2.1e-20 72.9 0.0 5.3e-20 71.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38488.1 - 7.8e-05 21.8 0.0 0.028 13.5 0.0 2.3 3 0 0 3 3 3 2 Protein tyrosine kinase CAF1A PF12253.3 EFE38489.1 - 0.016 15.3 2.2 0.029 14.4 1.5 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A DUF4637 PF15470.1 EFE38492.1 - 0.013 15.1 4.2 0.013 15.1 2.9 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4637) Sigma70_ner PF04546.8 EFE38492.1 - 1.6 8.2 7.7 0.33 10.5 2.9 1.6 2 0 0 2 2 2 0 Sigma-70, non-essential region PBP1_TM PF14812.1 EFE38493.1 - 0.13 12.6 1.1 0.16 12.2 0.7 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RED_N PF07808.8 EFE38493.1 - 0.13 11.4 1.5 0.14 11.3 1.1 1.0 1 0 0 1 1 1 0 RED-like protein N-terminal region ABC2_membrane_3 PF12698.2 EFE38494.1 - 0.07 12.1 21.1 0.096 11.6 14.6 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Myc_N PF01056.13 EFE38495.1 - 0.84 8.7 6.8 1 8.4 4.7 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PGA2 PF07543.7 EFE38495.1 - 1.1 9.1 9.1 1.8 8.3 6.3 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DSPc PF00782.15 EFE38496.1 - 9e-24 83.5 0.1 2.3e-21 75.7 0.0 2.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFE38496.1 - 0.026 13.8 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Beta-lactamase PF00144.19 EFE38497.1 - 2e-41 142.1 0.0 3.6e-41 141.2 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.3 EFE38497.1 - 1.1e-08 34.8 0.1 2.6e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Spt5_N PF11942.3 EFE38497.1 - 8.4 7.0 14.6 7.5 7.2 6.0 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal ABC_membrane PF00664.18 EFE38498.1 - 2.8e-81 272.9 41.0 1.6e-45 155.7 11.9 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE38498.1 - 8e-71 236.7 0.0 1.3e-34 119.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE38498.1 - 4.9e-16 58.6 5.2 5.7e-05 22.4 0.0 4.5 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE38498.1 - 9.3e-15 55.3 0.2 0.00085 19.3 0.0 4.3 2 2 0 3 3 3 3 AAA domain AAA_16 PF13191.1 EFE38498.1 - 6.6e-09 36.0 2.7 6.7e-05 22.9 0.3 3.3 2 2 1 3 3 3 2 AAA ATPase domain ABC_ATPase PF09818.4 EFE38498.1 - 1.3e-08 33.9 1.5 0.0031 16.1 0.0 2.6 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.1 EFE38498.1 - 4.1e-08 32.6 0.1 0.007 15.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 EFE38498.1 - 1.5e-07 30.7 0.0 0.011 14.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFE38498.1 - 2.9e-07 31.3 0.0 0.00099 19.9 0.0 3.1 3 0 0 3 3 2 1 AAA domain SbcCD_C PF13558.1 EFE38498.1 - 1.5e-05 24.8 1.2 0.25 11.2 0.1 3.6 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.9 EFE38498.1 - 2.7e-05 23.9 0.5 0.27 10.9 0.0 4.0 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EFE38498.1 - 2.8e-05 23.2 0.3 0.1 11.6 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.1 EFE38498.1 - 3.8e-05 23.8 2.4 0.059 13.5 0.3 3.9 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFE38498.1 - 0.00012 22.4 0.0 0.018 15.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE38498.1 - 0.00013 21.8 0.0 0.083 12.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFE38498.1 - 0.00032 20.9 1.3 18 5.5 0.2 4.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EFE38498.1 - 0.0011 18.8 0.1 2.5 7.9 0.0 3.5 4 0 0 4 4 3 1 AAA domain AAA_30 PF13604.1 EFE38498.1 - 0.0014 18.1 1.0 0.34 10.4 0.0 3.4 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.1 EFE38498.1 - 0.0026 18.1 0.0 3.1 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EFE38498.1 - 0.0033 17.3 0.4 0.58 10.1 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_10 PF12846.2 EFE38498.1 - 0.0037 16.7 0.8 1 8.6 0.0 3.5 4 0 0 4 4 4 1 AAA-like domain DUF815 PF05673.8 EFE38498.1 - 0.0045 15.9 0.0 0.84 8.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) PRK PF00485.13 EFE38498.1 - 0.0063 16.0 0.0 0.45 10.0 0.0 2.3 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.15 EFE38498.1 - 0.0066 15.1 0.0 0.3 9.7 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_25 PF13481.1 EFE38498.1 - 0.0082 15.5 0.1 1.8 7.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 EFE38498.1 - 0.013 14.5 0.1 5 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.1 EFE38498.1 - 0.013 15.4 0.0 2.3 8.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 EFE38498.1 - 0.015 14.9 0.1 0.18 11.5 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF3987 PF13148.1 EFE38498.1 - 0.017 13.6 0.0 0.14 10.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) ArgK PF03308.11 EFE38498.1 - 0.027 13.2 0.0 0.095 11.4 0.0 1.8 2 0 0 2 2 2 0 ArgK protein APS_kinase PF01583.15 EFE38498.1 - 0.054 13.1 0.0 2.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase RNA_helicase PF00910.17 EFE38498.1 - 0.059 13.5 0.1 8.3 6.6 0.0 3.0 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.12 EFE38498.1 - 0.069 12.9 0.2 13 5.5 0.0 2.9 3 0 0 3 3 2 0 Domain of unknown function DUF87 HTH_27 PF13463.1 EFE38498.1 - 0.096 13.0 0.0 0.43 10.9 0.0 2.1 2 0 0 2 2 1 0 Winged helix DNA-binding domain Cache_3 PF14827.1 EFE38498.1 - 0.21 11.4 3.2 2.6 7.9 0.0 2.6 2 0 0 2 2 2 0 Sensory domain of two-component sensor kinase Dynamin_N PF00350.18 EFE38498.1 - 0.43 10.3 3.1 7.6 6.3 0.1 4.1 5 1 0 5 5 4 0 Dynamin family AMP-binding PF00501.23 EFE38499.1 - 2.4e-152 507.1 0.0 7.9e-77 258.3 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 EFE38499.1 - 2.4e-114 381.2 0.0 6.8e-40 136.7 0.3 4.5 3 2 0 3 3 3 3 Condensation domain PP-binding PF00550.20 EFE38499.1 - 2.3e-31 107.8 0.1 3.1e-11 43.3 0.0 3.8 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE38499.1 - 1.8e-06 28.7 0.0 0.03 15.2 0.0 2.9 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain DUF4473 PF14747.1 EFE38499.1 - 0.034 14.3 0.0 0.092 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) Csm1 PF12539.3 EFE38499.1 - 0.049 14.1 0.2 0.66 10.4 0.0 2.5 2 0 0 2 2 2 0 Chromosome segregation protein Csm1/Pcs1 HpaB PF03241.8 EFE38499.1 - 0.1 11.4 0.0 0.28 10.0 0.0 1.7 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal AATase PF07247.7 EFE38499.1 - 0.29 9.6 2.6 4.1 5.8 0.3 3.1 2 1 0 2 2 2 0 Alcohol acetyltransferase GH3 PF03321.8 EFE38499.1 - 0.45 8.9 0.0 11 4.3 0.0 2.5 3 0 0 3 3 3 0 GH3 auxin-responsive promoter Methyltransf_18 PF12847.2 EFE38500.1 - 1.4e-17 64.2 0.0 2.2e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38500.1 - 1.5e-11 44.0 0.0 8.1e-10 38.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38500.1 - 5.3e-05 22.9 0.0 9.1e-05 22.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38500.1 - 0.00067 20.1 0.1 0.011 16.1 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE38500.1 - 0.0024 17.8 0.0 0.0041 17.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 EFE38500.1 - 0.0041 16.5 0.1 0.0074 15.6 0.1 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.7 EFE38500.1 - 0.024 15.0 1.2 0.11 13.0 0.1 2.4 2 1 0 2 2 2 0 Methyltransferase domain CENP-B_dimeris PF09026.5 EFE38500.1 - 0.037 14.2 5.9 0.066 13.4 4.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Methyltransf_25 PF13649.1 EFE38500.1 - 0.057 13.7 0.0 0.11 12.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 EFE38500.1 - 0.092 12.7 0.0 0.16 11.9 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase PBP1_TM PF14812.1 EFE38500.1 - 1.2 9.4 8.6 2.1 8.6 6.0 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.7 EFE38500.1 - 7.1 4.4 6.5 8.5 4.1 4.5 1.0 1 0 0 1 1 1 0 Nop14-like family Methyltransf_16 PF10294.4 EFE38501.1 - 2.7e-07 30.1 0.0 1.4e-05 24.5 0.0 2.2 1 1 0 1 1 1 1 Putative methyltransferase zf-C2H2_4 PF13894.1 EFE38502.1 - 0.01 16.0 1.7 0.034 14.4 1.2 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE38502.1 - 0.031 14.6 3.8 0.098 13.0 2.6 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type ING PF12998.2 EFE38503.1 - 3.1e-07 30.6 0.0 8e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Collagen PF01391.13 EFE38504.1 - 0.019 14.4 4.4 0.047 13.2 3.1 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) BAG PF02179.11 EFE38505.1 - 1.1e-07 31.8 0.0 2.2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 BAG domain SRP72 PF08492.7 EFE38506.1 - 0.2 12.0 5.8 0.22 11.9 4.0 1.1 1 0 0 1 1 1 0 SRP72 RNA-binding domain PBP1_TM PF14812.1 EFE38506.1 - 0.3 11.4 11.3 0.32 11.3 7.9 1.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TSGP1 PF07771.6 EFE38506.1 - 0.45 10.3 5.0 0.43 10.4 3.5 1.0 1 0 0 1 1 1 0 Tick salivary peptide group 1 DUF2890 PF11081.3 EFE38506.1 - 0.49 10.4 7.3 0.47 10.4 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Nucleoplasmin PF03066.10 EFE38506.1 - 0.61 9.5 11.9 0.65 9.4 8.3 1.0 1 0 0 1 1 1 0 Nucleoplasmin YL1 PF05764.8 EFE38506.1 - 0.73 9.3 14.8 0.75 9.3 10.3 1.0 1 0 0 1 1 1 0 YL1 nuclear protein TFIIF_alpha PF05793.7 EFE38506.1 - 0.89 7.8 15.3 0.86 7.9 10.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Cnd2 PF05786.9 EFE38506.1 - 1 7.7 12.6 1.2 7.6 8.7 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 SPT6_acidic PF14632.1 EFE38506.1 - 1.2 9.3 16.9 1.6 8.9 11.7 1.3 1 0 0 1 1 1 0 Acidic N-terminal SPT6 ERK-JNK_inhib PF15002.1 EFE38506.1 - 1.7 8.0 9.5 1.6 8.0 6.6 1.0 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor YqfQ PF14181.1 EFE38506.1 - 2.8 7.9 8.2 2.7 8.0 5.7 1.0 1 0 0 1 1 1 0 YqfQ-like protein HSP90 PF00183.13 EFE38506.1 - 2.8 6.2 12.8 2.8 6.2 8.9 1.0 1 0 0 1 1 1 0 Hsp90 protein BSP_II PF05432.6 EFE38506.1 - 3.2 6.9 10.4 2.9 7.0 7.2 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF788 PF05620.6 EFE38506.1 - 4.7 7.0 8.4 4.9 6.9 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF788) RNase_H2-Ydr279 PF09468.5 EFE38506.1 - 4.9 6.2 9.0 5.2 6.1 6.3 1.0 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Sec62 PF03839.11 EFE38506.1 - 6.9 6.0 7.0 6.5 6.1 4.8 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 CDC45 PF02724.9 EFE38506.1 - 7.1 4.5 9.0 6.9 4.5 6.2 1.0 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.9 EFE38506.1 - 7.3 6.5 7.1 7.1 6.6 4.9 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_polI_A34 PF08208.6 EFE38506.1 - 8.8 5.9 15.4 8.8 5.9 10.7 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 LMBR1 PF04791.11 EFE38507.1 - 1.4e-17 63.4 0.0 2.1e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein Ribosomal_60s PF00428.14 EFE38507.1 - 0.0023 18.2 3.5 0.0023 18.2 2.4 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein AgrB PF04647.10 EFE38508.1 - 0.0034 16.4 0.1 0.0045 16.0 0.1 1.1 1 0 0 1 1 1 1 Accessory gene regulator B Flavi_NS2B PF01002.14 EFE38508.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS2B Med15_fungi PF05397.7 EFE38509.1 - 2.9e-15 56.2 0.0 2.9e-15 56.2 0.0 6.2 7 1 1 8 8 8 1 Mediator complex subunit 15 Nuc_sug_transp PF04142.10 EFE38510.1 - 2.4e-08 33.4 0.2 4.5e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 EFE38510.1 - 1.1e-06 28.7 27.0 0.00045 20.2 4.5 3.2 2 1 1 3 3 3 3 EamA-like transporter family TPT PF03151.11 EFE38510.1 - 2e-05 24.2 16.4 0.0015 18.1 0.4 2.4 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 EFE38510.1 - 0.0018 17.2 15.7 0.0057 15.6 9.6 2.4 2 1 0 2 2 2 1 UAA transporter family EmrE PF13536.1 EFE38510.1 - 0.018 15.2 8.4 0.018 15.2 5.8 3.5 2 1 1 3 3 3 0 Multidrug resistance efflux transporter MBOAT PF03062.14 EFE38511.1 - 4.3e-27 95.0 19.6 5.4e-27 94.7 12.8 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Adaptin_N PF01602.15 EFE38512.1 - 1.1e-139 466.1 0.3 1.3e-139 465.9 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 EFE38512.1 - 1.9e-13 50.7 0.1 4.4e-13 49.5 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.1 EFE38512.1 - 2.4e-08 34.1 1.0 0.011 15.9 0.0 4.5 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 EFE38512.1 - 0.0002 21.1 1.1 13 6.1 0.0 5.1 4 1 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.1 EFE38512.1 - 0.00087 19.7 0.5 7 7.2 0.0 4.7 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.2 EFE38512.1 - 0.0049 16.7 3.8 0.02 14.7 0.2 3.5 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EFE38512.1 - 0.016 15.0 0.1 61 3.6 0.0 5.0 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat TIP120 PF08623.5 EFE38512.1 - 0.018 14.6 0.2 0.071 12.6 0.0 2.0 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Nipped-B_C PF12830.2 EFE38512.1 - 0.054 13.1 0.0 4.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus MFS_1 PF07690.11 EFE38515.1 - 2e-34 118.8 27.0 2.4e-34 118.6 18.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE38515.1 - 2.2e-10 39.6 5.3 2.2e-10 39.6 3.7 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFE38515.1 - 4.6e-05 21.8 1.4 7.4e-05 21.1 0.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 EFE38515.1 - 0.018 13.1 0.2 0.018 13.1 0.2 1.8 2 0 0 2 2 2 0 Transmembrane secretion effector UQ_con PF00179.21 EFE38516.1 - 2.8e-20 72.1 0.1 5.5e-20 71.2 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFE38516.1 - 0.00012 21.8 0.0 0.00067 19.4 0.0 1.9 2 0 0 2 2 2 1 Prokaryotic E2 family B RWD PF05773.17 EFE38516.1 - 0.046 13.6 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 RWD domain MKT1_C PF12246.3 EFE38517.1 - 3.6e-72 242.2 0.0 5.3e-72 241.7 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 EFE38517.1 - 8e-30 103.0 0.0 1.9e-29 101.8 0.0 1.7 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.13 EFE38517.1 - 2.6e-10 40.2 0.0 6e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 XPG I-region T2SG PF08334.6 EFE38517.1 - 0.076 12.7 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G DIOX_N PF14226.1 EFE38518.1 - 4.1e-13 49.8 0.2 5.7e-10 39.7 0.1 2.0 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF3452 PF11934.3 EFE38518.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) zf-MYND PF01753.13 EFE38519.1 - 1e-07 31.6 20.8 2.6e-07 30.4 14.4 1.7 1 0 0 1 1 1 1 MYND finger KAAG1 PF15354.1 EFE38520.1 - 0.00086 19.5 2.5 0.0015 18.8 0.8 2.1 2 1 1 3 3 3 1 Kidney-associated antigen 1 ATG27 PF09451.5 EFE38521.1 - 7.5e-25 87.6 10.9 3.3e-24 85.5 7.6 2.2 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.13 EFE38521.1 - 0.0027 17.4 0.1 1.8 8.2 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Vfa1 PF08432.5 EFE38521.1 - 0.19 11.7 8.1 0.27 11.2 5.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Prefoldin_2 PF01920.15 EFE38522.1 - 3.2e-22 78.2 4.0 4.4e-22 77.8 2.8 1.2 1 0 0 1 1 1 1 Prefoldin subunit Spore_III_AF PF09581.5 EFE38522.1 - 0.02 14.7 2.6 0.029 14.2 1.8 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Osmo_CC PF08946.5 EFE38522.1 - 0.025 14.5 1.5 0.073 13.1 1.1 1.8 1 0 0 1 1 1 0 Osmosensory transporter coiled coil TBCA PF02970.11 EFE38522.1 - 0.062 13.3 0.3 0.062 13.3 0.2 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A CENP-F_leu_zip PF10473.4 EFE38522.1 - 0.12 12.2 14.9 0.14 11.9 0.3 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.12 EFE38522.1 - 0.28 10.8 5.0 1.6 8.4 2.7 2.1 1 1 1 2 2 2 0 Prefoldin subunit TBPIP PF07106.8 EFE38522.1 - 0.31 10.5 0.1 0.31 10.5 0.0 2.0 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Seryl_tRNA_N PF02403.17 EFE38522.1 - 0.37 10.8 11.2 0.63 10.0 0.4 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FliD_C PF07195.7 EFE38522.1 - 0.41 9.8 3.0 1.4 8.1 0.0 2.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Nup54 PF13874.1 EFE38522.1 - 0.46 10.1 4.2 4.8 6.8 0.4 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 HalX PF08663.5 EFE38522.1 - 0.83 9.6 8.5 0.36 10.8 2.3 2.3 2 0 0 2 2 2 0 HalX domain GAS PF13851.1 EFE38522.1 - 1 8.4 11.0 5 6.2 0.2 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.6 EFE38522.1 - 3.3 6.3 9.3 1.6 7.3 0.2 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Viral_P18 PF04521.8 EFE38522.1 - 4.6 6.7 5.7 2.7 7.4 0.2 2.1 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DUF4164 PF13747.1 EFE38522.1 - 8.9 6.5 13.0 25 5.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF3847 PF12958.2 EFE38522.1 - 9 6.1 9.8 8 6.2 0.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3847) Fungal_trans PF04082.13 EFE38523.1 - 1.3e-23 83.2 0.3 1.9e-23 82.6 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain N2227 PF07942.7 EFE38524.1 - 8e-87 290.6 0.0 1.5e-86 289.7 0.0 1.4 1 1 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 EFE38524.1 - 0.056 13.1 0.0 0.13 11.9 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain HsdM_N PF12161.3 EFE38524.1 - 0.21 11.9 0.5 0.5 10.7 0.4 1.6 1 0 0 1 1 1 0 HsdM N-terminal domain Zip PF02535.17 EFE38524.1 - 0.49 9.3 2.8 0.22 10.4 0.5 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter ATG22 PF11700.3 EFE38526.1 - 5.9e-119 397.6 29.3 7.7e-119 397.2 20.3 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Ras PF00071.17 EFE38527.1 - 2.3e-53 179.9 0.3 2.9e-53 179.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE38527.1 - 9.1e-16 58.4 0.1 1.7e-15 57.5 0.0 1.4 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EFE38527.1 - 4.2e-12 45.6 0.1 5e-12 45.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFE38527.1 - 2.1e-08 33.8 0.0 2.6e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFE38527.1 - 0.00018 20.7 0.0 0.00021 20.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region CTP_transf_3 PF02348.14 EFE38527.1 - 0.051 13.2 0.2 0.16 11.5 0.1 1.7 1 1 1 2 2 2 0 Cytidylyltransferase AAT PF03417.11 EFE38527.1 - 0.064 12.6 0.1 0.095 12.1 0.1 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase NPHI_C PF08469.5 EFE38527.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Nucleoside triphosphatase I C-terminal Mitofilin PF09731.4 EFE38528.1 - 1.5e-145 486.1 21.5 2.9e-145 485.2 14.9 1.4 1 1 0 1 1 1 1 Mitochondrial inner membrane protein OmpH PF03938.9 EFE38528.1 - 2.7 7.9 14.6 0.49 10.3 7.4 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ATP-synt_B PF00430.13 EFE38528.1 - 6.8 6.5 20.6 7.3 6.4 5.4 2.6 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DSBA PF01323.15 EFE38532.1 - 8.6e-12 45.0 0.0 2.5e-11 43.4 0.0 1.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Bromodomain PF00439.20 EFE38533.1 - 1.9e-24 85.3 0.2 3.5e-24 84.5 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.19 EFE38533.1 - 1.1e-09 38.1 0.2 2.2e-09 37.2 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE38533.1 - 1.5e-09 37.9 0.4 3.4e-09 36.7 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE38533.1 - 0.027 14.2 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_10 PF13673.1 EFE38533.1 - 0.14 12.3 0.1 0.33 11.0 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Methyltransf_16 PF10294.4 EFE38535.1 - 4.4e-43 146.7 0.0 8.4e-41 139.3 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_26 PF13659.1 EFE38535.1 - 0.0002 21.3 0.0 0.00062 19.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38535.1 - 0.00047 20.5 0.1 0.0081 16.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38535.1 - 0.0013 18.5 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38535.1 - 0.0023 17.5 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE38535.1 - 0.0027 17.1 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EFE38535.1 - 0.0039 17.5 0.0 0.0079 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38535.1 - 0.0084 16.6 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFE38535.1 - 0.15 11.1 0.1 0.24 10.4 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Orn_Arg_deC_N PF02784.11 EFE38536.1 - 3.2e-76 255.8 0.0 4.6e-76 255.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 EFE38536.1 - 7.4e-29 99.8 0.0 1.2e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain cobW PF02492.14 EFE38537.1 - 3.5e-39 134.0 0.0 5.3e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 EFE38537.1 - 0.0009 18.9 0.0 0.0056 16.3 0.0 2.2 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.9 EFE38537.1 - 0.0012 18.6 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 EFE38537.1 - 0.0083 15.8 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 EFE38537.1 - 0.039 14.1 0.0 0.077 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 EFE38537.1 - 0.047 13.2 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 EFE38537.1 - 0.055 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Pox_A32 PF04665.7 EFE38537.1 - 0.061 12.6 0.0 0.15 11.3 0.0 1.5 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_29 PF13555.1 EFE38537.1 - 0.085 12.3 0.1 1.2 8.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_14 PF13173.1 EFE38537.1 - 0.094 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 EFE38537.1 - 0.15 10.9 0.0 0.28 10.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 EFE38537.1 - 0.17 12.2 0.0 0.6 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain SET PF00856.23 EFE38538.1 - 6.9e-06 26.4 0.0 2.9e-05 24.4 0.0 1.9 2 1 0 2 2 2 1 SET domain Glyco_transf_54 PF04666.8 EFE38539.1 - 1.4e-14 53.5 0.0 5.7e-11 41.6 0.0 3.1 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF2754 PF10953.3 EFE38539.1 - 0.0035 17.3 0.2 0.0077 16.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2754) DNA_mis_repair PF01119.14 EFE38540.1 - 4e-11 42.4 0.0 9.1e-11 41.2 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.21 EFE38541.1 - 2.6e-11 43.2 0.0 3.4e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EFE38541.1 - 1.2e-10 41.1 0.1 1.8e-10 40.5 0.1 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase APH PF01636.18 EFE38542.1 - 9.7e-16 58.2 0.1 2.8e-15 56.7 0.1 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.9 EFE38542.1 - 0.00047 19.2 0.0 0.00081 18.4 0.0 1.3 1 0 0 1 1 1 1 Fructosamine kinase Fungal_trans PF04082.13 EFE38543.1 - 0.0002 20.3 4.6 0.00064 18.6 0.6 2.4 1 1 1 2 2 2 2 Fungal specific transcription factor domain MFS_1 PF07690.11 EFE38544.1 - 2.2e-41 141.7 43.5 4e-41 140.9 28.3 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE38544.1 - 1.6e-07 29.9 16.8 2e-07 29.5 11.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Acetyltransf_3 PF13302.1 EFE38546.1 - 1.6e-33 115.8 0.0 2.6e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE38546.1 - 0.00024 21.0 0.1 0.00035 20.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 EFE38546.1 - 0.0026 17.6 0.0 0.0049 16.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Pkinase PF00069.20 EFE38547.1 - 3.6e-58 196.7 1.1 1.8e-53 181.3 0.0 2.6 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38547.1 - 6.7e-33 113.8 0.2 1.2e-31 109.6 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE38547.1 - 1.8e-06 27.1 0.0 2.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like POLO_box PF00659.13 EFE38547.1 - 2.9e-05 23.9 0.0 0.062 13.2 0.0 2.8 2 0 0 2 2 2 2 POLO box duplicated region Kdo PF06293.9 EFE38547.1 - 0.0094 15.0 0.1 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family OPA3 PF07047.7 EFE38548.1 - 2.4e-14 53.2 0.1 3.8e-14 52.6 0.0 1.4 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF390 PF04094.9 EFE38548.1 - 0.048 11.7 10.1 0.38 8.7 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF390) Myosin_head PF00063.16 EFE38549.1 - 2.6e-233 776.0 3.8 3.9e-233 775.4 2.6 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 EFE38549.1 - 3.2e-27 95.1 0.0 1.8e-18 66.5 0.0 2.5 2 0 0 2 2 2 2 Myosin tail SH3_1 PF00018.23 EFE38549.1 - 0.00076 18.8 0.0 0.0017 17.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain AAA_22 PF13401.1 EFE38549.1 - 0.0016 18.5 0.0 0.0076 16.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain IQ PF00612.22 EFE38549.1 - 0.0041 16.6 7.3 0.47 10.2 0.7 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif Hpr_kinase_C PF07475.7 EFE38549.1 - 0.013 14.7 0.4 1.6 7.9 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Zeta_toxin PF06414.7 EFE38549.1 - 0.023 13.8 0.0 0.053 12.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin SH3_2 PF07653.12 EFE38549.1 - 0.023 14.1 0.0 0.095 12.2 0.0 2.1 2 0 0 2 2 2 0 Variant SH3 domain AAA_17 PF13207.1 EFE38549.1 - 0.029 15.1 0.0 0.094 13.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.4 EFE38549.1 - 0.04 12.5 0.1 0.096 11.2 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.1 EFE38549.1 - 0.052 13.8 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain SH3_9 PF14604.1 EFE38549.1 - 0.053 13.1 0.0 0.19 11.3 0.0 2.0 1 0 0 1 1 1 0 Variant SH3 domain AAA_16 PF13191.1 EFE38549.1 - 0.068 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.7 EFE38549.1 - 0.15 11.6 0.0 0.43 10.2 0.0 1.7 2 0 0 2 2 2 0 NACHT domain DUF4229 PF14012.1 EFE38550.1 - 0.0063 16.3 1.6 0.019 14.8 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4229) DUF1180 PF06679.7 EFE38550.1 - 0.067 13.0 0.4 0.067 13.0 0.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) RSN1_TM PF13967.1 EFE38550.1 - 0.069 12.7 0.2 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport PsaM PF07465.8 EFE38550.1 - 2.4 7.8 5.8 4.2 7.0 4.1 1.4 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) p450 PF00067.17 EFE38551.1 - 2e-51 174.9 0.0 1e-33 116.5 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Gelsolin PF00626.17 EFE38552.1 - 0.13 11.9 0.3 0.26 11.0 0.2 1.6 1 1 0 1 1 1 0 Gelsolin repeat TrkH PF02386.11 EFE38554.1 - 1.8e-116 388.6 9.3 8.1e-114 379.8 3.2 2.1 2 0 0 2 2 2 2 Cation transport protein COesterase PF00135.23 EFE38555.1 - 4e-37 128.1 0.0 1.4e-29 103.2 0.0 2.7 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE38555.1 - 8.9e-09 35.2 0.0 1.6e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold ATP-synt_ab PF00006.20 EFE38556.1 - 1.3e-114 381.1 0.0 3.5e-114 379.6 0.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_M PF01031.15 EFE38556.1 - 2.5e-103 344.9 1.1 7.2e-103 343.4 0.0 2.2 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.18 EFE38556.1 - 4.2e-56 189.3 0.2 1e-55 188.1 0.2 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 EFE38556.1 - 2.3e-28 97.9 3.0 6.1e-28 96.5 2.1 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain ATP-synt_ab_C PF00306.22 EFE38556.1 - 2.2e-17 63.5 1.4 2.2e-17 63.5 1.0 2.2 3 0 0 3 3 3 1 ATP synthase alpha/beta chain, C terminal domain MMR_HSR1 PF01926.18 EFE38556.1 - 3.6e-05 23.6 0.1 0.00026 20.9 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE38556.1 - 0.0074 16.7 0.1 0.032 14.7 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 EFE38556.1 - 0.0079 16.2 0.0 7.4 6.5 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 EFE38556.1 - 0.079 12.8 0.0 2.2 8.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 EFE38556.1 - 0.1 12.5 0.0 8.1 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain WD40 PF00400.27 EFE38557.1 - 2.7e-35 118.9 8.5 3e-07 30.0 0.0 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat PD40 PF07676.7 EFE38557.1 - 0.00071 19.1 0.5 11 5.7 0.0 4.6 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat eIF2A PF08662.6 EFE38557.1 - 0.00095 18.9 0.0 0.11 12.1 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A CLTH PF10607.4 EFE38557.1 - 0.02 14.6 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain Cytochrom_D1 PF02239.11 EFE38557.1 - 0.13 10.5 0.0 0.98 7.6 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain DEAD PF00270.24 EFE38558.1 - 5.3e-40 136.6 0.3 1.2e-39 135.4 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE38558.1 - 2.7e-29 100.8 0.2 5.7e-29 99.8 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 EFE38558.1 - 0.0013 18.4 0.2 0.0035 17.0 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EFE38558.1 - 0.011 15.3 0.2 0.029 13.9 0.2 1.6 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 EFE38558.1 - 0.025 14.4 0.1 0.052 13.3 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 EFE38558.1 - 0.031 14.0 0.3 0.12 12.1 0.1 2.2 1 1 1 2 2 2 0 Flavivirus DEAD domain Helicase_RecD PF05127.9 EFE38558.1 - 0.067 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Helicase tRNA-synt_1b PF00579.20 EFE38558.1 - 0.1 11.7 0.0 0.25 10.4 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) AAA_11 PF13086.1 EFE38558.1 - 0.1 12.1 0.2 0.15 11.6 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFE38558.1 - 0.17 12.0 0.9 0.86 9.7 0.6 2.1 1 1 0 1 1 1 0 AAA domain DUF3449 PF11931.3 EFE38559.1 - 1.5e-72 243.2 0.2 1.5e-72 243.2 0.1 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) zf-met PF12874.2 EFE38559.1 - 1.6e-09 37.5 3.4 9.5e-08 31.9 0.6 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type SF3a60_bindingd PF12108.3 EFE38559.1 - 6.2e-09 35.2 0.1 1.3e-08 34.2 0.1 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_jaz PF12171.3 EFE38559.1 - 1.1e-07 31.7 0.7 1.1e-07 31.7 0.5 2.7 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EFE38559.1 - 0.00018 21.5 0.8 0.0078 16.3 0.2 2.8 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Myb_CC_LHEQLE PF14379.1 EFE38559.1 - 0.039 13.5 1.3 0.13 11.8 0.9 1.9 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif DUF951 PF06107.6 EFE38559.1 - 0.04 13.4 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) zf-LYAR PF08790.6 EFE38559.1 - 0.12 12.0 0.1 0.37 10.5 0.1 1.8 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2 PF00096.21 EFE38559.1 - 0.3 11.5 4.6 1.7 9.1 0.4 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE38559.1 - 0.44 11.0 3.5 3.7 8.0 0.2 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger DNA_ligase_A_M PF01068.16 EFE38561.1 - 1.2e-21 77.0 0.0 1.9e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EFE38561.1 - 1e-14 54.7 0.0 2e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus APC8 PF04049.8 EFE38562.1 - 1.3e-53 180.6 0.4 6e-53 178.4 0.0 2.3 3 0 0 3 3 3 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.23 EFE38562.1 - 1.4e-25 87.7 6.9 0.00015 21.2 0.0 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.12 EFE38562.1 - 4e-21 73.1 25.0 0.066 13.1 2.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.1 EFE38562.1 - 4.5e-21 74.2 17.6 3.5e-07 29.7 0.1 7.0 6 1 1 7 7 7 5 TPR repeat TPR_16 PF13432.1 EFE38562.1 - 3.7e-19 68.8 21.8 5.1e-05 23.8 0.0 7.7 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFE38562.1 - 3e-15 54.7 10.8 0.0003 20.3 0.0 8.0 6 1 2 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE38562.1 - 3.7e-15 55.0 15.2 0.0055 17.2 0.0 9.0 7 2 2 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFE38562.1 - 3.1e-13 49.8 10.9 0.0081 16.4 0.3 7.6 7 2 0 7 7 7 4 Tetratricopeptide repeat Apc3 PF12895.2 EFE38562.1 - 1.7e-11 44.0 10.9 0.26 11.4 0.1 6.9 6 1 2 8 8 8 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EFE38562.1 - 2.1e-11 43.5 20.8 0.00094 19.0 0.2 7.3 5 1 3 8 8 8 5 Tetratricopeptide repeat TPR_9 PF13371.1 EFE38562.1 - 3e-10 39.7 12.3 3.8e-05 23.4 0.2 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 EFE38562.1 - 3.7e-08 33.3 23.7 0.46 11.0 0.1 9.6 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFE38562.1 - 1.4e-07 31.1 7.7 0.49 10.7 0.0 7.0 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE38562.1 - 2.4e-05 23.7 10.4 4.1 7.4 0.1 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.1 EFE38562.1 - 0.00068 18.7 3.1 0.00068 18.7 2.1 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat PPR_3 PF13812.1 EFE38562.1 - 0.21 11.9 0.9 37 4.9 0.0 4.4 4 1 1 5 5 5 0 Pentatricopeptide repeat domain TPR_10 PF13374.1 EFE38562.1 - 0.88 9.5 17.2 16 5.5 0.0 7.1 9 0 0 9 9 8 0 Tetratricopeptide repeat polyprenyl_synt PF00348.12 EFE38563.1 - 2.8e-69 232.8 0.0 3.3e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Glycogen_syn PF05693.8 EFE38564.1 - 0 1023.3 0.0 0 1023.1 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.15 EFE38564.1 - 2.3e-06 27.1 0.0 0.0028 17.1 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EFE38564.1 - 2.3e-06 27.8 0.1 5.3e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.6 EFE38564.1 - 0.00011 21.7 0.0 0.00022 20.8 0.0 1.4 1 0 0 1 1 1 1 Starch synthase catalytic domain NPCC PF08058.6 EFE38566.1 - 3.3e-20 72.3 0.0 4.3e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore complex component AMP-binding PF00501.23 EFE38567.1 - 2.6e-14 52.4 0.0 9e-08 30.9 0.0 2.4 2 1 0 2 2 2 2 AMP-binding enzyme Ribosomal_L19 PF01245.15 EFE38569.1 - 2.5e-15 56.2 0.0 4.8e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L19 Methyltransf_24 PF13578.1 EFE38570.1 - 5.5e-12 46.4 0.0 1.7e-11 44.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 EFE38570.1 - 0.00082 18.4 0.2 0.015 14.3 0.1 2.6 2 1 0 2 2 2 1 O-methyltransferase Methyltransf_18 PF12847.2 EFE38570.1 - 0.016 15.8 0.0 0.041 14.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain DUF365 PF04033.7 EFE38570.1 - 0.044 13.7 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF365) Hap4_Hap_bind PF10297.4 EFE38571.1 - 3.8e-08 32.9 7.1 9.4e-08 31.6 4.9 1.7 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.16 EFE38571.1 - 1e-07 31.8 14.9 2.2e-07 30.7 9.9 1.9 1 1 0 1 1 1 1 bZIP transcription factor PSI_PsaF PF02507.10 EFE38571.1 - 0.13 11.7 1.2 0.24 10.9 0.8 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Phage_GP20 PF06810.6 EFE38571.1 - 0.16 11.4 6.8 0.3 10.5 4.7 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 IncA PF04156.9 EFE38571.1 - 0.6 9.6 6.1 1.1 8.8 4.2 1.4 1 0 0 1 1 1 0 IncA protein SlyX PF04102.7 EFE38571.1 - 1.1 9.7 6.9 3.5 8.0 4.7 2.0 1 1 1 2 2 2 0 SlyX bZIP_2 PF07716.10 EFE38571.1 - 1.2 9.0 20.5 3.9 7.3 13.0 2.4 1 1 1 2 2 2 0 Basic region leucine zipper V_ATPase_I PF01496.14 EFE38571.1 - 1.6 6.4 3.4 2.2 6.0 2.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mito_carr PF00153.22 EFE38572.1 - 2.1e-10 40.1 0.1 0.32 10.7 0.0 5.5 4 1 0 4 4 4 4 Mitochondrial carrier protein Fer2 PF00111.22 EFE38573.1 - 0.037 13.7 0.1 1.5 8.5 0.0 2.3 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Rrp15p PF07890.7 EFE38574.1 - 8.2e-36 122.9 7.4 8.2e-36 122.9 5.1 1.8 2 0 0 2 2 2 1 Rrp15p DUF1299 PF06975.6 EFE38574.1 - 0.11 12.3 0.7 0.11 12.3 0.5 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF1299) RRN3 PF05327.6 EFE38574.1 - 0.28 9.2 5.1 0.42 8.6 3.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Astro_capsid PF03115.9 EFE38574.1 - 0.3 9.3 10.1 0.39 8.9 7.0 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Nop14 PF04147.7 EFE38574.1 - 0.99 7.2 19.2 1.7 6.4 13.3 1.3 1 0 0 1 1 1 0 Nop14-like family SRP54 PF00448.17 EFE38575.1 - 1.3e-73 246.6 2.0 2.4e-73 245.7 1.4 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 EFE38575.1 - 2.4e-23 82.3 0.1 2.4e-23 82.3 0.1 4.5 3 1 1 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.14 EFE38575.1 - 2.7e-10 40.2 0.1 6e-10 39.0 0.1 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 EFE38575.1 - 9.6e-09 34.9 0.3 2.6e-08 33.4 0.2 1.8 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 EFE38575.1 - 1.6e-07 31.3 0.1 3.2e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE38575.1 - 5.4e-05 24.0 0.0 0.00013 22.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFE38575.1 - 8.1e-05 21.7 0.1 0.00015 20.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin MobB PF03205.9 EFE38575.1 - 0.00015 21.4 0.2 0.00047 19.8 0.0 1.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.18 EFE38575.1 - 0.0004 19.8 0.4 0.0012 18.2 0.3 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain APS_kinase PF01583.15 EFE38575.1 - 0.00063 19.4 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP_bind_1 PF03029.12 EFE38575.1 - 0.0015 18.1 0.4 0.02 14.4 0.1 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.1 EFE38575.1 - 0.0016 18.3 0.0 2 8.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain 6PF2K PF01591.13 EFE38575.1 - 0.0021 17.1 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase ArgK PF03308.11 EFE38575.1 - 0.0026 16.5 3.0 0.0044 15.8 0.0 2.5 3 0 0 3 3 3 1 ArgK protein SRPRB PF09439.5 EFE38575.1 - 0.0048 16.1 2.1 1.7 7.8 1.2 2.9 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Thymidylate_kin PF02223.12 EFE38575.1 - 0.006 15.9 0.2 0.02 14.2 0.1 1.9 1 0 0 1 1 1 1 Thymidylate kinase AAA_22 PF13401.1 EFE38575.1 - 0.0091 16.1 0.0 0.025 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EFE38575.1 - 0.026 13.9 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.1 EFE38575.1 - 0.027 14.4 0.0 0.054 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Arf PF00025.16 EFE38575.1 - 0.03 13.5 0.0 0.075 12.2 0.0 1.7 1 0 0 1 1 1 0 ADP-ribosylation factor family VirE PF05272.6 EFE38575.1 - 0.035 13.5 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Virulence-associated protein E AAA_19 PF13245.1 EFE38575.1 - 0.039 13.6 0.3 0.15 11.8 0.1 2.1 2 0 0 2 2 1 0 Part of AAA domain AAA_18 PF13238.1 EFE38575.1 - 0.045 14.0 0.1 0.11 12.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 EFE38575.1 - 0.048 12.6 0.2 0.091 11.7 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.4 EFE38575.1 - 0.065 11.8 0.1 0.15 10.6 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ABC_tran PF00005.22 EFE38575.1 - 0.082 13.1 0.9 0.26 11.6 0.1 2.1 2 1 0 2 2 2 0 ABC transporter AAA_28 PF13521.1 EFE38575.1 - 0.1 12.5 0.1 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoD PF09423.5 EFE38576.1 - 9.7e-50 169.4 0.0 1.4e-49 168.8 0.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase Glyco_hydro_18 PF00704.23 EFE38577.1 - 4.1e-08 33.0 0.0 6.4e-08 32.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_S3 PF00944.14 EFE38578.1 - 0.042 13.2 0.0 0.082 12.3 0.0 1.4 1 0 0 1 1 1 0 Alphavirus core protein Trypsin_2 PF13365.1 EFE38578.1 - 0.042 13.8 0.0 0.15 12.0 0.0 2.3 1 1 0 1 1 1 0 Trypsin-like peptidase domain Imm19 PF15567.1 EFE38578.1 - 0.14 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 19 adh_short_C2 PF13561.1 EFE38579.1 - 1e-26 94.1 0.0 1.3e-26 93.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFE38579.1 - 3.5e-21 75.8 7.1 2.2e-20 73.2 4.9 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE38579.1 - 6.4e-11 42.2 2.2 1.3e-10 41.2 1.6 1.5 1 1 0 1 1 1 1 KR domain CcmE PF03100.10 EFE38579.1 - 0.03 13.9 0.1 0.058 12.9 0.1 1.5 1 1 0 1 1 1 0 CcmE Reo_sigmaC PF04582.7 EFE38580.1 - 1.6 7.8 25.8 1.3 8.1 3.5 3.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein CoA_transf_3 PF02515.12 EFE38581.1 - 3.5e-50 169.9 0.0 4.7e-50 169.4 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III Nucleoporin_N PF08801.6 EFE38582.1 - 0.0086 14.8 0.0 0.093 11.4 0.0 2.1 2 0 0 2 2 2 1 Nup133 N terminal like zf-rbx1 PF12678.2 EFE38582.1 - 0.013 15.5 5.5 0.045 13.8 3.8 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_2 PF13639.1 EFE38582.1 - 3.9 7.3 12.5 0.045 13.5 2.0 2.8 2 1 0 2 2 2 0 Ring finger domain DUF2361 PF10153.4 EFE38583.1 - 1.8e-24 86.1 15.9 1.8e-24 86.1 11.0 3.2 3 1 0 3 3 3 1 Uncharacterised conserved protein (DUF2361) DUF573 PF04504.9 EFE38583.1 - 0.0043 17.3 2.2 0.0043 17.3 1.5 2.5 1 1 1 3 3 3 1 Protein of unknown function, DUF573 Neur_chan_memb PF02932.11 EFE38583.1 - 7.4 6.3 10.0 0.61 9.9 1.4 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region F-box-like PF12937.2 EFE38584.1 - 1.8e-11 43.5 0.2 4.7e-11 42.2 0.2 1.8 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.1 EFE38584.1 - 6.7e-11 41.0 22.2 0.012 15.6 0.1 7.7 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.2 EFE38584.1 - 2.9e-10 39.5 11.0 7e-06 25.5 0.7 5.4 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) F-box PF00646.28 EFE38584.1 - 5.2e-10 38.7 0.3 1.5e-09 37.2 0.2 1.8 1 0 0 1 1 1 1 F-box domain LRR_1 PF00560.28 EFE38584.1 - 7.2e-06 25.3 16.9 0.38 10.9 0.4 7.3 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_8 PF13855.1 EFE38584.1 - 4.8e-05 23.0 13.8 0.023 14.4 0.1 4.8 3 2 3 6 6 6 4 Leucine rich repeat LRR_7 PF13504.1 EFE38584.1 - 0.026 14.6 17.7 2.1 8.9 0.3 7.2 8 0 0 8 8 8 0 Leucine rich repeat PRANC PF09372.5 EFE38584.1 - 0.076 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 PRANC domain Pkinase PF00069.20 EFE38585.1 - 1.9e-57 194.3 0.0 3e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38585.1 - 4e-20 71.9 0.0 6.9e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE38585.1 - 5.5e-06 25.5 0.0 9e-06 24.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE38585.1 - 0.00021 21.1 0.1 0.00077 19.2 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFE38585.1 - 0.0039 16.5 0.2 0.0093 15.3 0.1 1.6 1 1 0 1 1 1 1 RIO1 family PAS_9 PF13426.1 EFE38585.1 - 0.019 15.3 0.1 1.9 8.8 0.0 3.5 4 1 0 4 4 4 0 PAS domain PAS_8 PF13188.1 EFE38585.1 - 0.029 14.2 0.0 4.9 7.1 0.0 2.9 3 0 0 3 3 3 0 PAS domain Choline_kinase PF01633.15 EFE38585.1 - 0.072 12.6 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RabGAP-TBC PF00566.13 EFE38586.1 - 1.1e-34 119.7 0.1 1.9e-34 119.0 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Yippee-Mis18 PF03226.9 EFE38588.1 - 3e-24 84.8 0.8 3.3e-24 84.7 0.5 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2039 PF10217.4 EFE38588.1 - 0.0051 16.7 1.7 0.042 13.8 0.2 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) HNH_5 PF14279.1 EFE38588.1 - 0.017 15.1 2.5 0.23 11.5 0.1 2.2 1 1 0 2 2 2 0 HNH endonuclease DUF4451 PF14616.1 EFE38588.1 - 0.02 14.6 1.7 0.028 14.1 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Evr1_Alr PF04777.8 EFE38588.1 - 0.029 14.2 2.5 0.36 10.7 0.1 2.1 1 1 1 2 2 2 0 Erv1 / Alr family RIG-I_C-RD PF11648.3 EFE38588.1 - 0.029 14.2 2.7 0.061 13.1 1.8 1.6 1 1 0 1 1 1 0 C-terminal domain of RIG-I Endonuclease_7 PF02945.10 EFE38588.1 - 0.033 13.8 2.4 0.067 12.9 1.6 1.7 1 1 0 1 1 1 0 Recombination endonuclease VII DiS_P_DiS PF06750.8 EFE38588.1 - 0.1 12.4 0.4 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain DZR PF12773.2 EFE38588.1 - 0.11 12.3 0.7 0.24 11.2 0.5 1.5 1 1 0 1 1 1 0 Double zinc ribbon Elf1 PF05129.8 EFE38588.1 - 0.12 12.0 0.8 2.5 7.8 0.1 2.1 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Eapp_C PF10238.4 EFE38588.1 - 0.46 10.3 5.0 0.84 9.5 0.9 2.1 1 1 1 2 2 2 0 E2F-associated phosphoprotein ADH_zinc_N PF00107.21 EFE38589.1 - 3e-21 75.3 0.0 4.4e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 EFE38589.1 - 0.056 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Dehydratase_hem PF13816.1 EFE38590.1 - 1.8e-118 395.1 0.0 2e-118 394.9 0.0 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.1 EFE38590.1 - 1.2e-08 35.0 0.1 0.00051 20.1 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4188) NAD_binding_2 PF03446.10 EFE38591.1 - 1.8e-25 89.7 0.0 3.9e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EFE38591.1 - 4.5e-11 42.8 0.9 7.3e-11 42.1 0.6 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 EFE38591.1 - 2.8e-06 27.6 0.2 1.1e-05 25.8 0.1 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 EFE38591.1 - 7.4e-06 26.1 0.0 1.5e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F-box-like PF12937.2 EFE38592.1 - 0.0014 18.2 0.9 0.0035 17.0 0.6 1.7 1 0 0 1 1 1 1 F-box-like Abhydrolase_6 PF12697.2 EFE38593.1 - 1.3e-21 77.5 1.7 3.1e-21 76.3 1.2 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE38593.1 - 6.3e-14 52.0 0.1 2.5e-11 43.5 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE38593.1 - 5.1e-08 32.7 0.7 6.9e-08 32.3 0.5 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EFE38593.1 - 6.7e-05 23.2 0.0 8.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 EFE38593.1 - 0.00038 20.1 0.1 0.00063 19.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Peptidase_S28 PF05577.7 EFE38593.1 - 0.013 14.1 0.0 0.018 13.6 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Abhydrolase_8 PF06259.7 EFE38593.1 - 0.068 12.6 0.1 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Thioredoxin PF00085.15 EFE38596.1 - 1e-58 195.4 0.0 1.4e-28 98.6 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.7 EFE38596.1 - 1.5e-23 83.1 0.5 3.7e-23 81.9 0.1 1.8 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.1 EFE38596.1 - 2.5e-15 56.6 0.0 1.5e-07 31.5 0.0 3.3 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 EFE38596.1 - 5.2e-12 45.6 0.0 8.6e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 EFE38596.1 - 3.9e-10 39.7 0.0 0.0038 17.3 0.0 3.6 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.16 EFE38596.1 - 1.5e-06 27.8 0.0 0.054 13.1 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_9 PF14595.1 EFE38596.1 - 0.00015 21.3 0.1 0.21 11.1 0.0 3.2 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_6 PF13848.1 EFE38596.1 - 0.00056 19.7 0.0 0.73 9.6 0.0 2.9 2 2 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_4 PF13462.1 EFE38596.1 - 0.00062 19.8 1.4 2.5 8.0 0.0 4.0 3 2 1 4 4 4 2 Thioredoxin Redoxin PF08534.5 EFE38596.1 - 0.0042 16.6 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 2 Redoxin Glutaredoxin PF00462.19 EFE38596.1 - 0.053 13.5 0.1 19 5.3 0.0 2.9 2 1 0 2 2 2 0 Glutaredoxin Thioredox_DsbH PF03190.10 EFE38596.1 - 0.16 11.7 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Ebp2 PF05890.7 EFE38597.1 - 1e-89 300.4 15.8 1e-89 300.4 10.9 2.2 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Nop14 PF04147.7 EFE38597.1 - 0.0023 15.9 42.8 0.0023 15.9 29.7 2.2 2 0 0 2 2 2 1 Nop14-like family TFIIA PF03153.8 EFE38597.1 - 8.3 6.2 43.8 4.8 6.9 25.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RNase_T PF00929.19 EFE38598.1 - 0.0044 17.3 0.1 0.023 14.9 0.0 2.1 2 0 0 2 2 2 1 Exonuclease E3_UbLigase_EDD PF11547.3 EFE38598.1 - 0.11 12.0 0.9 0.29 10.6 0.6 1.6 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD TruB_N PF01509.13 EFE38599.1 - 2.9e-44 150.8 0.0 1.3e-43 148.6 0.0 2.0 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) Rrn6 PF10214.4 EFE38601.1 - 0.29 9.1 3.6 0.36 8.8 2.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF3827 PF12877.2 EFE38601.1 - 1.1 7.2 4.3 1.2 7.1 3.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) OHCU_decarbox PF09349.5 EFE38602.1 - 2e-35 122.4 0.0 3e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 OHCU decarboxylase CorA PF01544.13 EFE38602.1 - 0.074 12.0 0.1 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein WD40 PF00400.27 EFE38603.1 - 1.6e-30 103.8 5.6 3.3e-07 29.9 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 EFE38603.1 - 0.0059 14.9 0.0 0.16 10.2 0.0 2.5 2 1 0 2 2 2 1 Cytochrome D1 heme domain Nup160 PF11715.3 EFE38603.1 - 0.0071 14.5 1.2 1.3 7.0 0.9 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 CBM_19 PF03427.8 EFE38603.1 - 0.049 13.4 0.4 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) IKI3 PF04762.7 EFE38603.1 - 0.07 10.9 0.0 6 4.5 0.0 2.2 1 1 0 2 2 2 0 IKI3 family BBS2_Mid PF14783.1 EFE38603.1 - 0.076 12.7 0.0 9.2 6.0 0.0 3.8 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region SRP9-21 PF05486.7 EFE38604.1 - 2.8e-29 100.6 0.5 3.9e-29 100.2 0.3 1.2 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Glyco_transf_90 PF05686.7 EFE38605.1 - 6.4e-12 44.8 10.4 6.3e-09 34.9 5.3 3.1 2 1 0 2 2 2 2 Glycosyl transferase family 90 CDO_I PF05995.7 EFE38607.1 - 7.1e-13 48.0 0.0 2.2e-05 23.6 0.0 3.3 3 0 0 3 3 3 3 Cysteine dioxygenase type I MMR_HSR1 PF01926.18 EFE38608.1 - 2.7e-08 33.7 0.0 6.3e-08 32.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFE38608.1 - 0.028 14.2 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Dynamin family GTP_EFTU PF00009.22 EFE38608.1 - 0.089 12.2 0.1 3 7.2 0.0 2.8 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain HTH_Tnp_Tc5 PF03221.11 EFE38611.1 - 1.1e-13 50.7 0.1 2.8e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 EFE38611.1 - 0.013 14.9 0.0 0.031 13.6 0.0 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain DUF3289 PF11692.3 EFE38611.1 - 0.062 12.5 0.0 0.091 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3289) Neisseria_TspB PF05616.8 EFE38612.1 - 0.086 11.1 4.9 0.12 10.7 3.4 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein PXA PF02194.10 EFE38613.1 - 1.5e-33 115.9 0.1 3.1e-19 69.2 0.2 2.2 2 0 0 2 2 2 2 PXA domain IU_nuc_hydro PF01156.14 EFE38614.1 - 1.5e-50 172.1 0.0 1.9e-50 171.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MR_MLE_C PF13378.1 EFE38615.1 - 5.1e-33 113.3 0.0 8e-33 112.7 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.11 EFE38615.1 - 4.4e-18 65.3 0.0 9.8e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MR_MLE PF01188.16 EFE38615.1 - 1.6e-09 38.1 0.0 4.3e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain Asp_protease_2 PF13650.1 EFE38618.1 - 0.045 14.2 0.0 0.062 13.8 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease OMPdecase PF00215.19 EFE38619.1 - 1.1e-65 221.1 0.1 1.3e-65 221.0 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family MAPEG PF01124.13 EFE38620.1 - 1.3e-18 66.8 1.7 1.6e-18 66.5 1.2 1.1 1 0 0 1 1 1 1 MAPEG family MBOAT PF03062.14 EFE38621.1 - 9.9e-24 84.0 15.1 9.9e-24 84.0 10.5 1.7 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 EFE38621.1 - 0.0086 16.1 2.7 0.025 14.6 1.9 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family BSMAP PF12280.3 EFE38621.1 - 0.027 14.3 0.8 0.054 13.3 0.3 1.6 2 0 0 2 2 2 0 Brain specific membrane anchored protein Zip PF02535.17 EFE38621.1 - 0.2 10.6 3.4 0.092 11.7 0.6 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter BAF1_ABF1 PF04684.8 EFE38621.1 - 1.5 7.5 14.9 2.1 7.0 10.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor HTH_29 PF13551.1 EFE38623.1 - 2.6e-07 30.7 0.1 2.6e-07 30.7 0.0 1.5 2 0 0 2 2 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 EFE38623.1 - 6.2e-07 29.3 0.7 3.4e-06 27.0 0.1 2.1 2 0 0 2 2 2 1 Transposase HTH_23 PF13384.1 EFE38623.1 - 8.8e-07 28.3 0.2 0.0008 18.9 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_38 PF13936.1 EFE38623.1 - 8.8e-06 25.1 1.0 0.0084 15.6 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_32 PF13565.1 EFE38623.1 - 8.8e-05 23.2 0.0 8.8e-05 23.2 0.0 2.8 1 1 1 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.7 EFE38623.1 - 0.00012 21.4 0.5 0.0071 15.7 0.0 2.8 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_20 PF12840.2 EFE38623.1 - 0.00023 20.9 0.0 0.52 10.1 0.0 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_24 PF13412.1 EFE38623.1 - 0.00081 18.7 0.7 0.77 9.1 0.1 3.0 2 1 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.5 EFE38623.1 - 0.0088 15.6 0.1 0.075 12.6 0.0 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_7 PF02796.10 EFE38623.1 - 0.033 14.0 4.1 0.22 11.3 1.4 2.9 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_AsnC-type PF13404.1 EFE38623.1 - 0.042 13.3 0.1 4.7 6.8 0.0 2.6 2 1 0 2 2 2 0 AsnC-type helix-turn-helix domain HTH_28 PF13518.1 EFE38623.1 - 0.049 13.6 0.0 0.049 13.6 0.0 2.8 3 0 0 3 3 2 0 Helix-turn-helix domain HTH_WhiA PF02650.9 EFE38623.1 - 0.066 13.6 0.1 0.25 11.7 0.0 1.9 1 1 1 2 2 2 0 WhiA C-terminal HTH domain Sigma70_r1_1 PF03979.9 EFE38623.1 - 0.071 13.0 0.1 0.17 11.8 0.0 1.6 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 TrmB PF01978.14 EFE38623.1 - 0.095 12.4 0.3 14 5.4 0.0 2.4 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_psq PF05225.11 EFE38623.1 - 0.14 11.7 0.4 22 4.6 0.0 2.6 2 0 0 2 2 2 0 helix-turn-helix, Psq domain COG4 PF08318.7 EFE38624.1 - 2e-12 46.5 0.0 3e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein Gly-zipper_OmpA PF13436.1 EFE38624.1 - 0.066 12.8 2.9 0.17 11.5 2.0 1.7 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Cupin_8 PF13621.1 EFE38625.1 - 4.3e-09 36.2 0.0 1e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 EFE38625.1 - 5.4e-09 36.3 0.0 5.2e-08 33.1 0.0 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.24 EFE38625.1 - 9.8e-09 34.7 8.1 9.8e-09 34.7 5.6 2.5 3 0 0 3 3 3 1 PHD-finger PHD_2 PF13831.1 EFE38625.1 - 5.8 6.3 9.7 6.8 6.0 5.2 2.4 2 0 0 2 2 2 0 PHD-finger Zn_clus PF00172.13 EFE38625.1 - 8.9 6.3 29.6 0.15 12.0 4.1 3.2 3 0 0 3 3 3 0 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_1 PF00076.17 EFE38626.1 - 2.1e-35 120.1 0.4 2.2e-16 59.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE38626.1 - 5.5e-27 93.5 0.1 2.4e-12 46.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE38626.1 - 1.5e-10 40.7 0.1 0.00037 20.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFE38626.1 - 0.0061 16.3 1.6 3.5 7.5 0.0 2.8 3 0 0 3 3 3 2 RNA binding motif MCRS_N PF13325.1 EFE38626.1 - 0.11 11.9 1.3 0.24 10.8 0.9 1.5 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein Med15 PF09606.5 EFE38626.1 - 0.21 9.7 76.1 0.31 9.1 52.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PRCC PF10253.4 EFE38627.1 - 0.2 12.3 10.6 0.25 12.0 7.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Herpes_TAF50 PF03326.8 EFE38627.1 - 0.2 10.5 12.0 0.23 10.3 8.3 1.0 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) DUF605 PF04652.11 EFE38627.1 - 0.56 9.5 17.5 0.63 9.3 12.1 1.0 1 0 0 1 1 1 0 Vta1 like AKAP2_C PF15304.1 EFE38627.1 - 1.2 8.6 8.8 1.4 8.4 6.1 1.0 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus DUF2413 PF10310.4 EFE38627.1 - 3.7 6.2 7.4 4.2 6.0 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) PAT1 PF09770.4 EFE38627.1 - 4.7 5.3 13.1 5 5.2 9.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 EFE38627.1 - 8.8 6.1 10.2 10 5.8 7.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med13_C PF06333.7 EFE38627.1 - 8.9 4.7 7.9 10 4.4 5.5 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal RabGAP-TBC PF00566.13 EFE38628.1 - 7.3e-45 153.0 0.0 3e-44 151.0 0.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RrnaAD PF00398.15 EFE38629.1 - 1.5e-50 171.6 0.2 6.3e-48 163.0 0.1 2.2 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 EFE38629.1 - 3.2e-08 33.6 0.0 6.9e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38629.1 - 1.2e-06 29.0 0.0 3.2e-06 27.7 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.14 EFE38629.1 - 0.00026 20.5 0.0 0.00045 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 EFE38629.1 - 0.00042 19.4 0.1 0.00069 18.7 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 EFE38629.1 - 0.00059 19.6 0.0 0.00096 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38629.1 - 0.0042 17.5 0.0 0.0097 16.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE38629.1 - 0.0056 16.0 0.0 0.0085 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 EFE38629.1 - 0.0097 16.3 0.0 0.051 14.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFE38629.1 - 0.021 13.8 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.13 EFE38629.1 - 0.029 13.4 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFE38629.1 - 0.038 13.5 0.0 0.071 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.7 EFE38629.1 - 0.04 12.7 0.0 0.065 12.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_2 PF00891.13 EFE38629.1 - 0.042 13.0 0.0 0.091 11.9 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_25 PF13649.1 EFE38629.1 - 0.067 13.5 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EFE38629.1 - 0.083 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.11 EFE38629.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein PRP1_N PF06424.7 EFE38630.1 - 9.9e-54 181.2 6.3 2.9e-53 179.7 4.4 1.9 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 EFE38630.1 - 5.5e-28 94.9 26.4 0.018 15.6 0.2 14.2 6 4 10 16 16 15 10 Tetratricopeptide repeat TPR_19 PF14559.1 EFE38630.1 - 1e-27 96.2 6.6 1.7e-05 25.0 0.0 9.6 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.1 EFE38630.1 - 4.1e-18 65.5 15.8 0.023 15.3 0.1 8.7 8 1 2 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.1 EFE38630.1 - 1.6e-13 50.0 7.4 0.0011 18.5 0.0 7.9 6 2 3 9 9 9 2 TPR repeat TPR_2 PF07719.12 EFE38630.1 - 4.6e-10 38.6 10.0 0.23 11.4 0.0 8.8 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_17 PF13431.1 EFE38630.1 - 3.6e-06 26.7 0.9 13 6.3 0.0 7.7 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFE38630.1 - 1.4e-05 24.4 0.1 0.35 10.7 0.1 6.2 5 1 1 6 6 6 1 Tetratricopeptide repeat NARP1 PF12569.3 EFE38630.1 - 1.5e-05 23.9 7.7 0.024 13.4 0.0 5.4 3 1 1 6 6 6 1 NMDA receptor-regulated protein 1 TPR_1 PF00515.23 EFE38630.1 - 0.00014 21.3 0.8 0.75 9.5 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE38630.1 - 0.0023 17.8 5.4 6 6.8 0.0 5.6 6 1 0 6 6 6 1 Tetratricopeptide repeat FAT PF02259.18 EFE38630.1 - 0.0025 16.8 9.8 0.42 9.5 0.3 3.5 1 1 2 3 3 3 2 FAT domain TPR_7 PF13176.1 EFE38630.1 - 0.029 14.1 3.1 14 5.7 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat SAGA-Tad1 PF12767.2 EFE38631.1 - 1.2e-57 195.5 0.0 1.7e-57 194.9 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit FUSC_2 PF13515.1 EFE38632.1 - 7.6e-30 103.4 10.0 7.6e-30 103.4 6.9 2.6 2 1 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.7 EFE38632.1 - 1.9e-08 33.2 17.6 2e-07 29.8 8.0 3.0 2 1 0 2 2 2 2 Fusaric acid resistance protein family ALMT PF11744.3 EFE38632.1 - 2.2e-07 29.8 18.6 0.0023 16.6 6.5 4.0 4 1 0 4 4 4 2 Aluminium activated malate transporter DUF2421 PF10334.4 EFE38632.1 - 0.00034 20.2 0.9 0.0013 18.3 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) Alk_phosphatase PF00245.15 EFE38633.1 - 7.5e-107 357.6 0.1 8.9e-107 357.3 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 EFE38633.1 - 7.2e-07 28.8 0.0 2.3e-05 23.9 0.0 2.4 2 1 0 2 2 2 1 Metalloenzyme superfamily DUF2749 PF10907.3 EFE38633.1 - 0.26 11.1 1.2 0.65 9.9 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) Methyltransf_2 PF00891.13 EFE38636.1 - 1.2e-26 93.4 0.1 3.3e-26 91.9 0.1 1.6 1 1 0 1 1 1 1 O-methyltransferase DUF3328 PF11807.3 EFE38637.1 - 5.3e-38 130.8 3.6 6.6e-38 130.5 2.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3785 PF12653.2 EFE38637.1 - 0.05 13.4 0.3 0.099 12.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) MFS_1 PF07690.11 EFE38640.1 - 4.7e-27 94.6 38.3 4.7e-27 94.6 26.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_M36 PF02128.10 EFE38642.1 - 8.1e-158 525.1 5.8 1e-157 524.8 4.0 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.8 EFE38642.1 - 1.9e-12 46.4 2.5 3.7e-12 45.5 1.7 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.10 EFE38642.1 - 0.0082 15.8 0.1 0.03 14.0 0.0 2.0 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain WD40 PF00400.27 EFE38645.1 - 1.2e-50 167.6 26.2 1.4e-08 34.3 0.3 11.5 11 0 0 11 11 11 8 WD domain, G-beta repeat BBS2_N PF14781.1 EFE38645.1 - 0.013 15.1 0.1 2.2 7.8 0.0 3.2 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal PD40 PF07676.7 EFE38645.1 - 0.028 14.0 0.0 45 3.8 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PPR_3 PF13812.1 EFE38647.1 - 3e-16 58.2 0.8 6.1e-05 22.9 0.0 8.1 8 0 0 8 8 8 3 Pentatricopeptide repeat domain PPR_2 PF13041.1 EFE38647.1 - 3.5e-12 46.1 0.3 0.00096 19.0 0.0 6.6 6 2 2 8 8 8 3 PPR repeat family PPR PF01535.15 EFE38647.1 - 1.4e-05 24.7 4.1 1.5 8.9 0.0 6.6 6 0 0 6 6 6 1 PPR repeat Myb_DNA-binding PF00249.26 EFE38648.1 - 4.7e-26 90.5 3.2 2.7e-09 36.9 0.2 3.3 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE38648.1 - 4.5e-25 87.5 0.5 1.5e-12 47.4 0.2 3.2 1 1 2 3 3 3 3 Myb-like DNA-binding domain Rap1_C PF11626.3 EFE38648.1 - 0.085 12.7 2.8 5.3 6.9 1.8 2.5 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MFS_1 PF07690.11 EFE38649.1 - 1.8e-49 168.3 52.1 2.2e-46 158.2 33.4 2.6 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE38649.1 - 9.3e-06 24.2 12.4 9.3e-06 24.2 8.6 3.0 2 1 0 2 2 2 1 MFS/sugar transport protein ELFV_dehydrog PF00208.16 EFE38650.1 - 4.6e-56 190.1 0.0 8.2e-56 189.2 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 EFE38650.1 - 4.5e-22 77.4 0.1 6.8e-15 53.6 0.0 2.6 3 0 0 3 3 3 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 EFE38650.1 - 0.057 12.9 0.0 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DUF4017 PF13209.1 EFE38651.1 - 0.0043 16.8 0.0 0.008 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4017) YwiC PF14256.1 EFE38651.1 - 0.082 12.9 1.8 0.14 12.2 1.3 1.3 1 0 0 1 1 1 0 YwiC-like protein TFIIIC_sub6 PF10419.4 EFE38652.1 - 3.8e-16 58.2 0.1 3.8e-16 58.2 0.1 1.7 2 0 0 2 2 2 1 TFIIIC subunit MgpC PF05220.7 EFE38652.1 - 0.14 11.2 0.0 3.7 6.5 0.0 2.3 2 0 0 2 2 2 0 MgpC protein precursor TRP PF06011.7 EFE38653.1 - 3.5e-131 437.7 6.9 4.9e-131 437.3 4.8 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EFE38653.1 - 5.6e-32 110.7 0.6 9e-32 110.0 0.4 1.4 1 0 0 1 1 1 1 ML-like domain DUF3154 PF11351.3 EFE38653.1 - 0.61 9.8 3.7 0.93 9.2 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3154) Hep_59 PF07052.6 EFE38654.1 - 1.3e-10 41.5 0.7 1.3e-10 41.5 0.5 3.3 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 p450 PF00067.17 EFE38655.1 - 1.1e-50 172.4 0.0 2.3e-50 171.5 0.0 1.4 2 0 0 2 2 2 1 Cytochrome P450 Rabaptin PF03528.10 EFE38655.1 - 0.19 11.6 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Rabaptin Rab_eff_C PF04698.7 EFE38656.1 - 0.012 13.8 0.2 0.015 13.4 0.1 1.1 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus Pkinase PF00069.20 EFE38658.1 - 2e-64 217.2 0.0 2.8e-64 216.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38658.1 - 5.2e-31 107.6 0.0 8.9e-31 106.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE38658.1 - 2.4e-05 23.4 0.0 4.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE38658.1 - 0.00058 18.9 0.1 0.0033 16.4 0.0 2.2 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 EFE38658.1 - 0.0061 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4360 PF14273.1 EFE38659.1 - 1.6e-36 125.7 0.3 1.9e-36 125.4 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Cadherin-like PF12733.2 EFE38659.1 - 0.12 12.6 0.5 0.23 11.7 0.1 1.6 2 0 0 2 2 2 0 Cadherin-like beta sandwich domain SNARE PF05739.14 EFE38660.1 - 0.0082 15.8 0.6 0.66 9.7 0.0 2.4 2 0 0 2 2 2 2 SNARE domain Pneumovirus_M2 PF06436.6 EFE38660.1 - 0.03 13.5 0.1 0.052 12.7 0.1 1.3 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) DUF566 PF04484.7 EFE38660.1 - 7.4 5.9 16.6 1.7 8.0 0.7 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF566) Sugar_tr PF00083.19 EFE38661.1 - 4e-85 286.0 27.9 2.4e-82 276.9 19.3 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE38661.1 - 1e-15 57.3 28.0 1e-15 57.3 19.4 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3464 PF11947.3 EFE38661.1 - 0.51 9.7 3.8 1.3 8.4 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) zf-CCHC PF00098.18 EFE38662.1 - 3.3e-11 42.5 31.9 9.4e-06 25.3 1.7 5.3 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_5 PF14787.1 EFE38662.1 - 0.028 13.9 2.8 0.028 13.9 1.9 3.2 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.1 EFE38662.1 - 0.08 12.6 16.2 4 7.2 4.8 4.1 2 1 1 3 3 3 0 Zinc knuckle DUF846 PF05832.7 EFE38663.1 - 9.1e-40 135.6 4.1 9.1e-40 135.6 2.8 1.3 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF846) Acyl-CoA_dh_1 PF00441.19 EFE38664.1 - 2.4e-31 108.8 0.1 3.3e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFE38664.1 - 4.2e-18 64.5 0.7 7.6e-18 63.7 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 EFE38664.1 - 2.7e-15 56.9 0.0 1.3e-14 54.7 0.0 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EFE38664.1 - 0.0097 16.1 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ECH PF00378.15 EFE38665.1 - 1.3e-43 148.8 0.0 1.8e-43 148.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family HpcH_HpaI PF03328.9 EFE38666.1 - 7.6e-41 139.4 0.1 8.4e-40 135.9 0.0 2.3 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 EFE38666.1 - 2.5e-13 49.5 1.3 1.3e-06 27.4 0.0 2.5 3 0 0 3 3 3 2 C-C_Bond_Lyase of the TIM-Barrel fold WEMBL PF05701.6 EFE38666.1 - 0.0032 16.0 4.4 0.0046 15.4 3.1 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light TBPIP PF07106.8 EFE38666.1 - 0.0034 16.9 1.2 0.0057 16.2 0.8 1.3 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HAP1_N PF04849.8 EFE38666.1 - 0.0036 16.2 4.0 0.0061 15.5 2.8 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DUF972 PF06156.8 EFE38666.1 - 0.004 17.4 3.0 0.0076 16.5 2.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF972) APG6 PF04111.7 EFE38666.1 - 0.0044 16.1 4.5 0.0066 15.5 3.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Dor1 PF04124.7 EFE38666.1 - 0.0044 15.5 0.8 0.007 14.8 0.5 1.2 1 0 0 1 1 1 1 Dor1-like family DUF4201 PF13870.1 EFE38666.1 - 0.01 15.2 5.2 0.018 14.4 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) V_ATPase_I PF01496.14 EFE38666.1 - 0.015 13.1 0.8 0.024 12.5 0.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATP-synt_B PF00430.13 EFE38666.1 - 0.017 14.9 3.3 0.037 13.8 2.3 1.5 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) COG2 PF06148.6 EFE38666.1 - 0.028 14.2 1.0 0.074 12.9 0.7 1.6 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF812 PF05667.6 EFE38666.1 - 0.032 12.7 1.8 0.047 12.2 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) PK PF00224.16 EFE38666.1 - 0.053 12.1 0.0 0.097 11.2 0.0 1.4 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain Occludin_ELL PF07303.8 EFE38666.1 - 0.11 13.2 3.8 0.2 12.4 2.6 1.3 1 0 0 1 1 1 0 Occludin homology domain DUF357 PF04010.8 EFE38666.1 - 0.11 12.2 0.1 0.25 11.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF357) Sec34 PF04136.10 EFE38666.1 - 0.11 12.1 1.0 0.21 11.2 0.7 1.4 1 0 0 1 1 1 0 Sec34-like family V-SNARE PF05008.10 EFE38666.1 - 0.12 12.5 5.8 0.24 11.5 4.0 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Synaptobrevin PF00957.16 EFE38666.1 - 0.14 11.7 1.2 0.35 10.4 0.8 1.7 1 0 0 1 1 1 0 Synaptobrevin EzrA PF06160.7 EFE38666.1 - 0.16 10.1 5.0 0.23 9.6 3.5 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Lsr2 PF11774.3 EFE38666.1 - 0.2 11.5 4.5 0.053 13.4 0.7 1.8 2 0 0 2 2 1 0 Lsr2 DivIC PF04977.10 EFE38666.1 - 0.2 11.1 4.9 0.47 9.9 3.4 1.6 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.9 EFE38666.1 - 0.3 10.6 6.2 0.55 9.7 4.3 1.3 1 0 0 1 1 1 0 IncA protein Prominin PF05478.6 EFE38666.1 - 0.31 8.5 1.0 0.45 7.9 0.7 1.1 1 0 0 1 1 1 0 Prominin YlqD PF11068.3 EFE38666.1 - 0.57 10.2 10.3 0.92 9.5 6.4 1.9 2 0 0 2 2 2 0 YlqD protein GAS PF13851.1 EFE38666.1 - 0.58 9.3 8.1 1 8.5 5.6 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding EMP24_GP25L PF01105.19 EFE38666.1 - 0.91 9.2 3.6 1.6 8.4 2.5 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF4337 PF14235.1 EFE38666.1 - 1.8 8.3 5.4 3.2 7.5 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) GrpE PF01025.14 EFE38666.1 - 2.7 7.4 7.2 4.7 6.7 5.0 1.3 1 0 0 1 1 1 0 GrpE DUF1771 PF08590.5 EFE38667.1 - 2.8e-15 56.0 3.6 2.8e-15 56.0 2.5 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) Smr PF01713.16 EFE38667.1 - 1.1e-10 41.5 0.1 4.9e-10 39.4 0.0 2.2 2 0 0 2 2 2 1 Smr domain zf-CCCH PF00642.19 EFE38667.1 - 1.4e-07 30.9 1.0 0.0014 18.2 0.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) CUE PF02845.11 EFE38667.1 - 0.067 12.6 0.1 0.14 11.6 0.1 1.5 1 0 0 1 1 1 0 CUE domain Glyco_transf_90 PF05686.7 EFE38668.1 - 3.7e-16 58.8 1.8 2e-11 43.2 0.7 2.9 2 1 0 2 2 2 2 Glycosyl transferase family 90 UBN2_3 PF14244.1 EFE38669.1 - 0.00015 21.3 0.3 0.00021 20.8 0.2 1.2 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Oxidored_molyb PF00174.14 EFE38670.1 - 7.2e-41 139.4 0.0 1e-40 138.9 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 EFE38670.1 - 1.1e-11 44.4 0.0 2e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain NAD_binding_1 PF00175.16 EFE38671.1 - 1.6e-25 89.7 0.0 6.5e-25 87.8 0.0 2.0 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFE38671.1 - 1.6e-23 82.6 0.0 2.7e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 EFE38671.1 - 2.4e-15 56.0 0.1 8.3e-15 54.3 0.0 1.9 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.7 EFE38671.1 - 0.00078 19.3 0.4 0.041 13.7 0.0 2.7 2 1 1 3 3 3 1 Ferric reductase NAD binding domain CAP59_mtransfer PF11735.3 EFE38672.1 - 5.6e-83 277.8 0.0 7.6e-83 277.4 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 AICARFT_IMPCHas PF01808.13 EFE38673.1 - 7.6e-109 363.5 0.0 1.1e-108 363.0 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 EFE38673.1 - 4.5e-25 87.4 0.0 8.3e-25 86.5 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain DUF346 PF03984.8 EFE38674.1 - 8.9e-17 60.2 55.1 0.0015 17.9 3.4 7.2 7 0 0 7 7 7 6 Repeat of unknown function (DUF346) Toxin_42 PF15522.1 EFE38674.1 - 5.4e-05 22.4 0.0 38 3.3 0.0 6.2 7 0 0 7 7 7 0 Putative toxin 42 DUF1724 PF08350.5 EFE38674.1 - 0.0049 16.3 10.5 0.43 10.1 0.0 5.0 5 0 0 5 5 5 1 Domain of unknown function (DUF1724) Stap_Strp_toxin PF01123.15 EFE38674.1 - 0.076 13.4 0.0 29 5.2 0.0 4.6 6 1 1 7 7 7 0 Staphylococcal/Streptococcal toxin, OB-fold domain DUF3147 PF11345.3 EFE38674.1 - 0.15 12.1 2.4 1.3e+02 2.6 0.0 4.9 7 0 0 7 7 7 0 Protein of unknown function (DUF3147) SNARE_assoc PF09335.6 EFE38675.1 - 5e-05 23.4 9.1 5e-05 23.4 6.3 3.4 2 1 1 3 3 3 1 SNARE associated Golgi protein HAMP PF00672.20 EFE38675.1 - 0.68 10.1 0.0 0.68 10.1 0.0 2.8 3 0 0 3 3 3 0 HAMP domain Amino_oxidase PF01593.19 EFE38676.1 - 5.3e-89 299.3 0.0 2.2e-88 297.3 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.12 EFE38676.1 - 3.3e-11 43.1 0.0 7.5e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.1 EFE38676.1 - 1.8e-07 31.0 0.1 3.8e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.14 EFE38676.1 - 0.00013 22.1 2.1 0.00013 22.1 1.4 2.4 2 1 0 2 2 2 1 HMG (high mobility group) box DAO PF01266.19 EFE38676.1 - 0.0014 17.5 0.1 0.032 13.1 0.1 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFE38676.1 - 0.088 12.8 0.1 0.48 10.4 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE38676.1 - 0.11 12.3 0.2 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFE38676.1 - 0.14 11.9 0.4 1.5 8.5 0.1 2.5 2 1 0 2 2 2 0 FAD-NAD(P)-binding DUF3431 PF11913.3 EFE38676.1 - 1.6 8.1 4.5 19 4.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3431) Pyr_redox_2 PF07992.9 EFE38677.1 - 2.9e-27 95.8 0.0 4.6e-27 95.2 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE38677.1 - 4.3e-16 59.0 0.5 1.5e-13 50.9 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE38677.1 - 4.5e-09 36.6 0.0 3.7e-05 23.8 0.0 3.1 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 EFE38677.1 - 2.9e-05 24.2 0.0 0.0095 16.1 0.0 2.6 1 1 1 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.12 EFE38677.1 - 5.6e-05 22.3 1.3 9.1e-05 21.6 0.1 1.9 2 1 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.1 EFE38677.1 - 0.0002 21.2 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFE38677.1 - 0.0024 16.8 0.1 0.64 8.8 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.15 EFE38677.1 - 0.0077 16.3 0.2 2.8 8.0 0.0 2.7 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 EFE38677.1 - 0.021 13.7 5.8 1.1 8.1 0.1 3.8 2 2 2 4 4 4 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFE38677.1 - 0.021 13.8 0.5 3.1 6.7 0.0 2.4 2 1 0 2 2 2 0 FAD binding domain GIDA PF01134.17 EFE38677.1 - 0.023 13.5 4.9 1.7 7.4 0.0 3.7 3 1 2 5 5 5 0 Glucose inhibited division protein A FAD_binding_2 PF00890.19 EFE38677.1 - 0.18 10.5 5.6 0.29 9.9 0.2 2.9 2 2 1 3 3 3 0 FAD binding domain DUF3799 PF12684.2 EFE38678.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 PDDEXK-like domain of unknown function (DUF3799) APH PF01636.18 EFE38679.1 - 5.6e-16 59.0 0.0 8e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE38679.1 - 1.4e-10 41.1 0.0 3e-10 40.0 0.0 1.5 2 0 0 2 2 2 1 Choline/ethanolamine kinase Pkinase PF00069.20 EFE38679.1 - 2e-05 23.8 0.0 0.00032 19.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain DUF1679 PF07914.6 EFE38679.1 - 0.041 12.5 0.0 0.54 8.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) ImmE5 PF11480.3 EFE38681.1 - 0.017 14.9 0.0 0.15 11.8 0.0 2.3 3 0 0 3 3 3 0 Colicin-E5 Imm protein CitG PF01874.11 EFE38681.1 - 0.087 12.0 0.0 0.39 9.8 0.0 1.8 1 1 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase Trypan_PARP PF05887.6 EFE38682.1 - 0.72 9.6 16.5 1 9.1 11.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TRAP_alpha PF03896.11 EFE38682.1 - 3.3 6.6 9.0 4.5 6.1 6.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Daxx PF03344.10 EFE38682.1 - 4.1 5.7 18.4 4.6 5.6 12.8 1.1 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EFE38682.1 - 5.9 4.6 16.0 5.8 4.6 11.1 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 EFE38682.1 - 6.8 5.8 14.7 7.4 5.7 10.2 1.2 1 0 0 1 1 1 0 SDA1 Peptidase_S8 PF00082.17 EFE38683.1 - 5e-51 173.5 3.9 5e-51 173.5 2.7 1.4 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 EFE38683.1 - 3.4e-29 100.4 1.0 6.6e-29 99.5 0.7 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Mucin PF01456.12 EFE38683.1 - 1.5 8.5 13.6 3.1 7.5 9.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein PAT1 PF09770.4 EFE38684.1 - 1.9e-259 863.2 24.0 2.1e-259 863.1 16.6 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 NAD_binding_10 PF13460.1 EFE38685.1 - 1.4e-24 87.1 0.0 1.6e-24 86.9 0.0 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFE38685.1 - 3.7e-10 39.4 0.0 5.8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 EFE38685.1 - 4.1e-07 29.6 0.0 6.3e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFE38685.1 - 9.8e-06 24.4 0.0 1.3e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 EFE38685.1 - 7.1e-05 21.9 0.0 0.00012 21.2 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 EFE38686.1 - 3e-41 141.3 0.0 6.8e-25 87.8 0.0 2.2 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 EFE38686.1 - 4.6e-26 90.5 0.1 8.2e-26 89.7 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 EFE38686.1 - 5.5e-12 44.9 0.0 4.5e-05 22.2 0.0 2.2 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 EFE38686.1 - 1.3e-11 44.7 0.0 7.7e-10 38.9 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFE38686.1 - 1.4e-08 34.6 0.0 1.1e-07 31.7 0.0 2.0 1 1 1 2 2 2 1 KR domain Polysacc_synt_2 PF02719.10 EFE38686.1 - 4.4e-07 29.1 0.1 6.7e-05 21.9 0.0 2.8 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 EFE38686.1 - 4.5e-07 30.0 0.0 2e-06 27.9 0.0 1.9 1 1 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 EFE38686.1 - 9.4e-07 27.9 0.0 0.0073 15.2 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_4 PF07993.7 EFE38686.1 - 3e-05 23.0 0.0 0.15 10.9 0.0 2.4 2 1 0 2 2 2 2 Male sterility protein DAO PF01266.19 EFE38686.1 - 0.00054 18.9 0.1 0.0019 17.1 0.2 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase NmrA PF05368.8 EFE38686.1 - 0.003 16.8 0.0 0.0074 15.5 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family adh_short_C2 PF13561.1 EFE38686.1 - 0.0036 17.1 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase UDPG_MGDP_dh_N PF03721.9 EFE38686.1 - 0.0042 16.4 0.1 0.0074 15.6 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 EFE38686.1 - 0.0056 16.3 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_18 PF12847.2 EFE38686.1 - 0.015 15.8 0.0 10 6.7 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain ELFV_dehydrog PF00208.16 EFE38686.1 - 0.09 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase adh_short PF00106.20 EFE38687.1 - 2.9e-12 46.7 0.0 6.5e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE38687.1 - 3.3e-07 30.1 0.0 7.3e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE38687.1 - 0.0031 17.3 0.0 0.0065 16.2 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFE38687.1 - 0.0036 17.3 0.1 0.0098 15.9 0.1 1.7 2 0 0 2 2 2 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 EFE38687.1 - 0.11 12.2 1.2 0.26 11.1 0.3 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase G-patch PF01585.18 EFE38688.1 - 9.1e-09 34.9 0.5 2e-08 33.8 0.4 1.6 1 0 0 1 1 1 1 G-patch domain Sec1 PF00995.18 EFE38689.1 - 9.6e-127 423.9 0.0 1.1e-126 423.7 0.0 1.0 1 0 0 1 1 1 1 Sec1 family SUV3_C PF12513.3 EFE38690.1 - 1.1e-15 56.8 0.0 2.2e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 EFE38690.1 - 1.2e-05 25.0 0.0 6.3e-05 22.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.18 EFE38691.1 - 7.4e-29 99.7 0.1 1.9e-28 98.4 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EFE38691.1 - 5.4e-20 71.3 0.0 3.7e-19 68.6 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EFE38691.1 - 3.3e-12 46.0 0.0 9.2e-12 44.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.18 EFE38691.1 - 3.8e-10 39.6 0.9 1.1e-09 38.2 0.6 1.8 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.24 EFE38691.1 - 7.1e-05 22.3 0.0 0.00016 21.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 EFE38691.1 - 0.00029 19.8 0.0 0.00069 18.5 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 EFE38691.1 - 0.0082 16.2 0.0 0.023 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE38691.1 - 0.012 15.3 0.3 0.068 12.9 0.1 2.2 2 0 0 2 2 2 0 Part of AAA domain RS4NT PF08071.7 EFE38691.1 - 0.082 12.7 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 RS4NT (NUC023) domain Npa1 PF11707.3 EFE38693.1 - 4.2e-91 305.3 0.8 4.2e-91 305.3 0.6 1.7 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NUC153 PF08159.7 EFE38694.1 - 4.3e-12 45.4 0.1 4.3e-12 45.4 0.1 4.1 4 0 0 4 4 4 1 NUC153 domain DUF4148 PF13663.1 EFE38694.1 - 0.041 13.7 0.0 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) CLTH PF10607.4 EFE38695.1 - 8.8e-31 106.5 0.4 1.2e-30 106.1 0.3 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 EFE38695.1 - 8.7e-05 22.1 0.0 0.00019 21.0 0.0 1.6 1 0 0 1 1 1 1 LisH Pyr_redox_2 PF07992.9 EFE38696.1 - 1.7e-13 50.8 0.0 6.8e-13 48.9 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE38696.1 - 1e-10 41.8 0.0 1.6e-09 38.0 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.27 EFE38696.1 - 1.6e-05 23.8 0.1 5.8e-05 22.1 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 EFE38696.1 - 0.0002 20.5 0.1 0.00051 19.2 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 EFE38696.1 - 0.00022 20.8 0.2 0.00077 19.1 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 EFE38696.1 - 0.0013 18.8 0.1 0.0045 17.1 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair Myc_N PF01056.13 EFE38696.1 - 0.23 10.6 0.0 0.37 9.9 0.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region EF-hand_4 PF12763.2 EFE38696.1 - 0.24 11.1 0.9 3.1 7.5 0.0 2.9 4 0 0 4 4 4 0 Cytoskeletal-regulatory complex EF hand HEAT_2 PF13646.1 EFE38697.1 - 5.6e-31 106.6 6.9 4.4e-15 55.7 0.1 3.5 3 1 1 4 4 4 2 HEAT repeats HEAT_PBS PF03130.11 EFE38697.1 - 1.3e-20 71.7 1.8 0.0027 18.0 0.0 6.7 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT_EZ PF13513.1 EFE38697.1 - 1.5e-08 34.8 10.5 0.0012 19.3 0.1 5.7 2 2 4 6 6 6 5 HEAT-like repeat HEAT PF02985.17 EFE38697.1 - 4.3e-06 26.3 2.3 1.8 8.8 0.0 5.5 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.18 EFE38697.1 - 0.019 14.7 0.1 12 5.9 0.0 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Imm16 PF15565.1 EFE38697.1 - 0.1 12.4 0.5 0.99 9.2 0.1 2.4 3 0 0 3 3 3 0 Immunity protein 16 RuvA_C PF07499.8 EFE38697.1 - 0.14 12.2 0.9 5 7.3 0.0 3.4 3 0 0 3 3 3 0 RuvA, C-terminal domain Paramyxo_PNT PF13825.1 EFE38697.1 - 0.2 10.8 1.7 0.65 9.1 0.0 2.3 3 0 0 3 3 3 0 Paramyxovirus structural protein V/P N-terminus Methyltransf_11 PF08241.7 EFE38698.1 - 6.6e-06 26.5 0.0 0.0077 16.6 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38698.1 - 0.0012 19.2 0.0 0.12 12.7 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38698.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38698.1 - 0.05 14.1 0.0 6.9 7.2 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain Nipped-B_C PF12830.2 EFE38699.1 - 1.9e-52 177.6 10.6 1.4e-51 174.8 0.7 4.2 3 1 0 3 3 3 2 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 EFE38699.1 - 3.2e-11 42.9 6.5 7.5e-11 41.7 1.5 3.4 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.17 EFE38699.1 - 0.00028 20.7 1.3 0.4 10.8 0.1 4.9 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.15 EFE38699.1 - 0.023 13.0 9.0 0.3 9.3 4.9 3.5 2 1 1 3 3 3 0 Adaptin N terminal region Cnd1 PF12717.2 EFE38699.1 - 0.024 14.4 5.7 0.15 11.9 0.7 3.8 2 2 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.2 EFE38699.1 - 0.088 13.2 0.8 1.4 9.3 0.1 3.0 1 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region ETC_C1_NDUFA4 PF04800.7 EFE38700.1 - 4.8e-32 109.8 1.5 8e-32 109.1 1.0 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Orthopox_C10L PF07020.6 EFE38701.1 - 0.015 15.7 2.5 7 7.2 0.1 3.3 2 0 0 2 2 2 0 Orthopoxvirus C10L protein MOZ_SAS PF01853.13 EFE38702.1 - 1.1e-83 279.1 0.0 1.6e-83 278.6 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 EFE38702.1 - 1.5e-17 62.9 0.1 2.6e-16 59.0 0.0 2.4 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain DUF1918 PF08940.6 EFE38702.1 - 0.018 14.3 0.0 0.068 12.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) CD24 PF14984.1 EFE38702.1 - 0.15 11.9 0.9 0.41 10.4 0.1 2.0 2 0 0 2 2 2 0 CD24 protein Myb_Cef PF11831.3 EFE38703.1 - 2.6e-58 196.9 1.3 2.6e-58 196.9 0.9 3.5 5 0 0 5 5 5 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.26 EFE38703.1 - 6.1e-20 71.0 3.8 4.2e-09 36.3 0.3 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE38703.1 - 2.1e-19 69.3 6.0 7.9e-13 48.3 1.1 3.1 2 1 1 3 3 3 2 Myb-like DNA-binding domain Nop53 PF07767.6 EFE38704.1 - 1.4e-109 366.6 37.6 2e-109 366.1 26.1 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) RNase_T PF00929.19 EFE38705.1 - 4.6e-28 98.5 0.0 7.3e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 EFE38705.1 - 0.094 12.1 0.0 0.24 10.8 0.0 1.6 1 1 0 1 1 1 0 3'-5' exonuclease RNase_H2_suC PF08615.6 EFE38706.1 - 1.3e-14 54.2 0.1 2.6e-12 46.7 0.1 2.3 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Alk_phosphatase PF00245.15 EFE38707.1 - 1.6e-72 244.5 1.9 2.3e-72 244.0 1.3 1.2 1 0 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.18 EFE38707.1 - 2.2e-07 30.3 3.1 2.1e-06 27.1 2.1 2.2 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 EFE38707.1 - 4e-06 26.4 0.8 6.9e-06 25.6 0.6 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.12 EFE38707.1 - 0.0011 17.4 0.2 0.0019 16.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) GPAT_N PF14829.1 EFE38707.1 - 0.026 14.1 0.0 0.052 13.2 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal FTA4 PF13093.1 EFE38707.1 - 0.1 12.0 0.1 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DcpS_C PF11969.3 EFE38708.1 - 1.7e-30 105.5 0.3 2.8e-30 104.9 0.2 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.7 EFE38708.1 - 9.5e-28 96.8 0.0 1.5e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal KR PF08659.5 EFE38709.1 - 5.9e-18 65.1 0.0 1.4e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 EFE38709.1 - 5.7e-17 62.1 0.1 3e-16 59.7 0.0 2.2 3 0 0 3 3 3 1 short chain dehydrogenase Acyl_transf_1 PF00698.16 EFE38709.1 - 8.3e-10 38.4 0.0 1.6e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain ADH_zinc_N PF00107.21 EFE38709.1 - 1.3e-08 34.4 0.0 4.7e-08 32.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PS-DH PF14765.1 EFE38709.1 - 4.8e-05 22.6 0.0 9.9e-05 21.6 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Peptidase_C12 PF01088.16 EFE38711.1 - 3.4e-58 196.3 0.0 3.8e-58 196.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 MT-A70 PF05063.9 EFE38712.1 - 3e-25 88.8 0.0 7.6e-25 87.4 0.0 1.6 2 0 0 2 2 2 1 MT-A70 PUF PF00806.14 EFE38713.1 - 7e-29 97.6 0.0 1.2e-05 24.4 0.0 6.1 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.17 EFE38713.1 - 9.9e-11 41.1 0.0 2.1e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE38713.1 - 2.8e-07 30.2 0.0 6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE38713.1 - 6.1e-06 26.1 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) IQ PF00612.22 EFE38714.1 - 0.11 12.2 0.8 0.29 10.9 0.5 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif tRNA-synt_2 PF00152.15 EFE38715.1 - 7.4e-58 195.9 0.5 9.5e-58 195.5 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFE38715.1 - 1.2e-08 34.6 0.0 2.4e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Rep_fac-A_3 PF08661.6 EFE38715.1 - 0.086 12.7 0.0 0.48 10.3 0.0 2.2 2 1 0 2 2 2 0 Replication factor A protein 3 YL1 PF05764.8 EFE38717.1 - 3.3e-57 193.8 25.1 3.3e-57 193.8 17.4 1.7 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.6 EFE38717.1 - 3.5e-12 45.6 0.2 5.9e-12 44.9 0.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Ribosomal_60s PF00428.14 EFE38718.1 - 2.4 8.6 9.4 10 6.5 0.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Fungal_trans PF04082.13 EFE38720.1 - 9.6e-22 77.0 0.1 1.9e-21 76.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE38720.1 - 9.2e-10 38.2 12.7 2.1e-09 37.1 8.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FGF-BP1 PF06473.7 EFE38720.1 - 0.025 14.1 2.0 0.042 13.4 1.4 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Thymidylat_synt PF00303.14 EFE38721.1 - 1.6e-111 371.6 0.0 1.8e-111 371.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase zf-AN1 PF01428.11 EFE38722.1 - 6.8e-24 83.4 22.9 6.8e-13 48.2 5.7 2.3 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.16 EFE38722.1 - 0.005 16.6 5.1 0.005 16.6 3.5 3.1 2 1 0 2 2 2 1 IBR domain Transp_Tc5_C PF04236.10 EFE38722.1 - 0.042 14.0 15.7 0.23 11.7 2.6 2.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Hist_deacetyl PF00850.14 EFE38723.1 - 3.2e-58 197.4 0.0 5.1e-58 196.8 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain R3H-assoc PF13902.1 EFE38724.1 - 3.3e-27 95.0 13.6 7.1e-19 68.0 1.5 2.5 2 0 0 2 2 2 2 R3H-associated N-terminal domain R3H PF01424.17 EFE38724.1 - 0.0062 16.2 0.0 0.018 14.7 0.0 1.8 1 0 0 1 1 1 1 R3H domain STAT_int PF02865.12 EFE38724.1 - 0.21 11.5 2.4 0.28 11.1 0.7 1.8 1 1 0 1 1 1 0 STAT protein, protein interaction domain Peptidase_M28 PF04389.12 EFE38725.1 - 2.3e-29 102.4 0.0 3.8e-29 101.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EFE38725.1 - 0.01 15.3 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 DUF1774 PF08611.5 EFE38726.1 - 9.1e-34 115.5 1.2 9.1e-34 115.5 0.8 2.0 2 1 0 2 2 2 1 Fungal protein of unknown function (DUF1774) Glyco_transf_54 PF04666.8 EFE38726.1 - 0.019 13.7 0.0 0.029 13.1 0.0 1.2 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region dCMP_cyt_deam_1 PF00383.17 EFE38727.1 - 9e-08 31.7 0.0 1.2e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Chitin_synth_1 PF01644.12 EFE38728.1 - 3.6e-83 277.2 0.2 7.5e-83 276.2 0.0 1.6 2 0 0 2 2 2 1 Chitin synthase Chitin_synth_1N PF08407.6 EFE38728.1 - 2.9e-34 116.6 0.1 7.9e-34 115.2 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EFE38728.1 - 3.5e-23 81.8 3.1 1.4e-21 76.5 0.0 2.2 1 1 1 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 EFE38728.1 - 3.7e-08 33.3 0.3 3.7e-08 33.3 0.2 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFE38728.1 - 5.7e-05 23.0 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 AFG1_ATPase PF03969.11 EFE38729.1 - 6e-90 301.6 0.0 2.3e-84 283.2 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.1 EFE38729.1 - 0.00021 21.3 1.8 0.46 10.4 0.0 3.4 2 2 0 3 3 3 2 AAA ATPase domain AAA_14 PF13173.1 EFE38729.1 - 0.0023 17.8 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EFE38729.1 - 0.0025 17.9 0.0 0.014 15.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE38729.1 - 0.11 12.6 0.0 0.56 10.3 0.0 2.2 2 1 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 EFE38729.1 - 0.13 11.9 0.3 2.2 7.8 0.0 2.6 2 1 0 2 2 2 0 Bacterial dnaA protein Mg_chelatase PF01078.16 EFE38729.1 - 0.15 11.2 0.0 0.4 9.8 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PX PF00787.19 EFE38730.1 - 9.3e-14 51.1 0.0 1.6e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.23 EFE38730.1 - 9.4e-12 44.1 1.0 3.3e-11 42.3 0.0 2.4 2 0 0 2 2 2 1 SH3 domain PB1 PF00564.19 EFE38730.1 - 2.2e-07 30.4 0.4 4.2e-07 29.5 0.3 1.4 1 0 0 1 1 1 1 PB1 domain SH3_9 PF14604.1 EFE38730.1 - 3.6e-07 29.6 0.6 1.1e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 EFE38730.1 - 0.0075 15.7 0.3 0.016 14.6 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain Pex14_N PF04695.8 EFE38730.1 - 7.4 6.6 16.9 5.2 7.1 0.2 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BLVR PF06375.6 EFE38731.1 - 7.4 6.3 11.2 9.3 6.0 6.6 1.8 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) Nop14 PF04147.7 EFE38732.1 - 1.4e-07 29.9 1.8 1.7e-07 29.5 1.3 1.0 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.9 EFE38732.1 - 0.0014 16.7 1.2 0.0018 16.4 0.8 1.1 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.7 EFE38732.1 - 0.0056 16.0 7.7 0.008 15.5 5.4 1.2 1 0 0 1 1 1 1 SDA1 YL1 PF05764.8 EFE38732.1 - 0.13 11.7 16.5 0.24 10.9 11.5 1.4 1 1 0 1 1 1 0 YL1 nuclear protein eIF-3c_N PF05470.7 EFE38732.1 - 1.9 6.4 6.1 2.4 6.1 4.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SAC3_GANP PF03399.11 EFE38733.1 - 1.7e-68 230.2 0.1 2.2e-68 229.8 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 EFE38733.1 - 2.2e-06 27.5 0.1 6.5e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 LLC1 PF14945.1 EFE38733.1 - 8.6 6.7 9.6 14 6.0 0.3 3.3 3 0 0 3 3 3 0 Normal lung function maintenance, Low in Lung Cancer 1 protein EAP30 PF04157.11 EFE38735.1 - 6.9e-48 162.7 0.2 9e-48 162.3 0.2 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 EFE38735.1 - 5.3e-24 83.8 0.0 1.1e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.10 EFE38735.1 - 0.00038 19.9 7.3 0.00046 19.6 0.1 3.3 3 0 0 3 3 3 1 Sec23/Sec24 zinc finger zf-RanBP PF00641.13 EFE38735.1 - 0.0021 17.1 9.5 0.0038 16.3 0.2 2.6 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others GRAM PF02893.15 EFE38735.1 - 0.0051 16.3 0.0 0.0095 15.4 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Cas_CXXC_CXXC PF09706.5 EFE38735.1 - 0.061 13.5 0.4 8.3 6.6 0.0 2.6 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) zf-MIZ PF02891.15 EFE38735.1 - 0.092 12.2 0.1 0.092 12.2 0.1 1.8 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger DZR PF12773.2 EFE38735.1 - 1.7 8.4 6.0 3.1 7.6 0.9 2.4 1 1 2 3 3 3 0 Double zinc ribbon SprA-related PF12118.3 EFE38736.1 - 0.00016 21.1 9.2 0.00017 20.9 6.4 1.1 1 0 0 1 1 1 1 SprA-related family Plasmodium_Vir PF05795.6 EFE38736.1 - 0.003 16.8 8.9 0.0041 16.3 6.2 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein ATG22 PF11700.3 EFE38736.1 - 0.1 11.0 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Serinc PF03348.10 EFE38736.1 - 0.33 9.6 9.2 2 7.0 6.3 1.9 1 1 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.12 EFE38736.1 - 0.5 9.1 5.6 0.65 8.7 3.8 1.2 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.11 EFE38736.1 - 0.83 8.1 2.5 1.1 7.7 1.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SAPS PF04499.10 EFE38736.1 - 2.1 6.8 6.9 2.6 6.5 4.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.7 EFE38736.1 - 2.1 8.1 16.6 3.9 7.2 11.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.8 EFE38736.1 - 3.1 6.2 20.5 0.099 11.1 9.7 1.6 1 1 1 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 ETRAMP PF09716.5 EFE38736.1 - 3.7 7.5 14.7 3.9 7.5 0.0 3.2 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) zf-C2H2 PF00096.21 EFE38737.1 - 2.4e-18 65.2 33.8 2.6e-05 24.3 1.2 5.0 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFE38737.1 - 2.1e-17 62.4 8.8 1.8e-07 31.0 0.9 5.8 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFE38737.1 - 6.6e-13 48.0 30.9 0.00029 20.9 3.1 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE38737.1 - 3.2e-05 23.9 13.8 0.12 12.5 0.1 5.2 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFE38737.1 - 0.0037 17.0 17.5 0.69 9.9 0.2 4.7 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.2 EFE38737.1 - 0.02 15.0 17.9 0.27 11.4 0.2 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type XPA_N PF01286.13 EFE38737.1 - 0.076 12.7 0.4 0.076 12.7 0.3 3.1 4 0 0 4 4 4 0 XPA protein N-terminal Yippee-Mis18 PF03226.9 EFE38737.1 - 0.25 11.3 2.7 5.2 7.1 0.2 2.5 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2072 PF09845.4 EFE38737.1 - 0.74 9.7 4.5 0.27 11.1 0.8 2.0 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) Zn-ribbon_8 PF09723.5 EFE38737.1 - 1.2 9.1 12.6 20 5.2 0.1 4.0 2 1 1 3 3 3 0 Zinc ribbon domain C1_4 PF07975.7 EFE38737.1 - 1.7 8.6 6.2 4 7.5 0.2 3.0 1 1 2 3 3 3 0 TFIIH C1-like domain Arc_trans_TRASH PF08394.5 EFE38737.1 - 2.5 8.3 4.9 11 6.2 0.3 3.2 3 1 0 3 3 3 0 Archaeal TRASH domain Methyltransf_23 PF13489.1 EFE38738.1 - 7.4e-21 74.5 0.0 1.8e-20 73.2 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38738.1 - 5.1e-13 49.3 0.1 1.1e-12 48.2 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38738.1 - 1.1e-12 48.2 0.0 1.8e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38738.1 - 4.1e-11 43.4 0.0 6.4e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38738.1 - 3.4e-09 36.4 0.0 6.3e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE38738.1 - 2e-07 31.0 0.1 3.8e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38738.1 - 7.2e-07 29.5 0.0 1.2e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFE38738.1 - 0.0068 15.5 0.1 0.58 9.1 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.1 EFE38738.1 - 0.0097 16.7 0.0 0.018 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 EFE38738.1 - 0.043 13.2 0.0 1.9 7.8 0.0 2.1 2 0 0 2 2 2 0 Nodulation protein S (NodS) DUF605 PF04652.11 EFE38738.1 - 0.067 12.5 3.6 0.11 11.8 2.5 1.3 1 0 0 1 1 1 0 Vta1 like Methyltransf_28 PF02636.12 EFE38738.1 - 0.072 12.4 0.0 0.097 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Prp18 PF02840.10 EFE38738.1 - 0.16 11.7 0.2 0.16 11.7 0.1 1.8 2 0 0 2 2 2 0 Prp18 domain Dscam_C PF12355.3 EFE38738.1 - 0.67 10.2 5.1 2 8.6 3.5 1.7 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal E_Pc_C PF06752.7 EFE38738.1 - 1 8.8 5.9 3.3 7.1 0.7 2.3 3 0 0 3 3 3 0 Enhancer of Polycomb C-terminus Mito_fiss_reg PF05308.6 EFE38738.1 - 3.6 6.8 12.5 7 5.9 8.7 1.5 1 1 0 1 1 1 0 Mitochondrial fission regulator E1-E2_ATPase PF00122.15 EFE38741.1 - 1.2e-66 224.0 2.9 2.2e-66 223.1 2.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE38741.1 - 7.8e-33 113.5 3.6 7.8e-33 113.5 2.5 2.3 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE38741.1 - 1.5e-28 100.7 0.0 1.8e-27 97.2 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE38741.1 - 6.8e-24 83.6 0.0 1.5e-23 82.5 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 EFE38741.1 - 7e-14 51.0 0.1 1.7e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 EFE38741.1 - 2.2e-12 47.5 0.0 1.7e-11 44.6 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE38741.1 - 1.6e-05 24.6 0.8 0.0011 18.6 0.5 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Senescence_reg PF04520.8 EFE38741.1 - 0.0039 17.6 0.5 0.0081 16.6 0.4 1.4 1 0 0 1 1 1 1 Senescence regulator BTV_NS2 PF04514.7 EFE38741.1 - 0.57 9.0 3.6 0.89 8.3 2.5 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 BRAP2 PF07576.7 EFE38742.1 - 2.7e-25 88.0 0.0 4.9e-25 87.2 0.0 1.3 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.14 EFE38742.1 - 4.7e-20 71.4 4.0 1.6e-19 69.8 2.8 2.0 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 EFE38742.1 - 2e-09 37.1 10.0 2e-09 37.1 6.9 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 EFE38742.1 - 7.5e-05 22.3 7.2 7.5e-05 22.3 5.0 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFE38742.1 - 0.00049 19.6 7.7 0.00049 19.6 5.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE38742.1 - 0.0008 19.0 5.7 0.0008 19.0 3.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE38742.1 - 0.0011 18.8 9.0 0.0011 18.8 6.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFE38742.1 - 0.0022 17.6 3.9 0.007 16.0 1.5 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.2 EFE38742.1 - 0.0023 17.9 5.2 0.0023 17.9 3.6 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EFE38742.1 - 0.0073 16.1 5.3 0.019 14.7 3.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_RING PF05883.6 EFE38742.1 - 0.066 13.0 2.9 0.2 11.5 2.0 1.7 1 1 0 1 1 1 0 Baculovirus U-box/Ring-like domain ApoO PF09769.4 EFE38742.1 - 0.21 11.3 1.3 0.28 10.8 0.0 1.8 2 0 0 2 2 2 0 Apolipoprotein O zf-RING_6 PF14835.1 EFE38742.1 - 0.28 10.9 10.3 0.047 13.4 3.5 2.3 1 1 1 2 2 2 0 zf-RING of BARD1-type protein TPR_MLP1_2 PF07926.7 EFE38742.1 - 0.35 10.5 16.9 0.13 11.9 9.9 1.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Prok-RING_4 PF14447.1 EFE38742.1 - 0.36 10.3 6.0 7.3 6.2 2.1 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF1993 PF09351.5 EFE38742.1 - 0.75 9.7 6.9 0.69 9.8 1.3 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF1993) zf-RING_4 PF14570.1 EFE38742.1 - 1.3 8.6 6.2 3.8 7.1 4.3 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF904 PF06005.7 EFE38742.1 - 2.5 8.4 6.8 0.42 10.9 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF4200 PF13863.1 EFE38742.1 - 6 6.8 16.9 10 6.0 2.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) V_ATPase_I PF01496.14 EFE38742.1 - 6.4 4.5 6.7 11 3.7 4.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APH PF01636.18 EFE38743.1 - 6.2e-16 58.8 0.0 1.6e-15 57.5 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE38743.1 - 0.0019 17.7 0.1 0.0043 16.6 0.1 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.20 EFE38743.1 - 0.008 15.3 0.0 0.021 13.9 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain ubiquitin PF00240.18 EFE38744.1 - 1.8e-91 299.5 14.2 2e-33 113.5 0.7 3.4 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.3 EFE38744.1 - 1.1e-50 169.1 10.5 1e-18 66.7 0.6 3.3 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 EFE38744.1 - 1.7e-15 57.0 6.0 0.00016 21.8 0.2 4.0 3 2 0 3 3 3 3 Ubiquitin-like domain Telomere_Sde2 PF13019.1 EFE38744.1 - 5e-10 39.3 0.3 0.027 14.1 0.0 3.5 3 0 0 3 3 3 3 Telomere stability and silencing DUF2407 PF10302.4 EFE38744.1 - 4.9e-09 36.2 0.9 0.15 12.2 0.0 3.4 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 EFE38744.1 - 4.7e-08 32.8 1.4 0.089 12.6 0.0 3.6 2 1 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2870 PF11069.3 EFE38744.1 - 3.5e-05 23.7 0.1 0.33 11.0 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF2870) FlgD_ig PF13860.1 EFE38744.1 - 0.001 18.7 3.8 6.8 6.4 0.1 3.4 3 0 0 3 3 3 2 FlgD Ig-like domain Big_3_3 PF13750.1 EFE38744.1 - 0.0045 16.4 0.8 0.36 10.2 0.2 2.7 1 1 1 2 2 2 1 Bacterial Ig-like domain (group 3) TUG-UBL1 PF11470.3 EFE38744.1 - 0.0055 16.5 4.1 13 5.7 0.1 3.6 4 0 0 4 4 3 0 GLUT4 regulating protein TUG Tash_PEST PF07708.6 EFE38744.1 - 0.3 11.0 19.8 5.2 7.1 1.2 3.5 3 0 0 3 3 3 0 Tash protein PEST motif Plexin_cytopl PF08337.7 EFE38744.1 - 0.34 9.1 10.8 6.6 4.9 0.2 3.9 3 2 0 3 3 3 0 Plexin cytoplasmic RasGAP domain FERM_N PF09379.5 EFE38744.1 - 0.52 10.3 4.7 93 3.1 0.0 4.1 3 2 0 3 3 3 0 FERM N-terminal domain DUF2631 PF10939.3 EFE38746.1 - 0.14 11.9 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2631) Cupin_1 PF00190.17 EFE38747.1 - 5.8e-25 87.4 0.0 5.5e-12 45.3 0.0 2.4 2 1 0 2 2 2 2 Cupin Cupin_2 PF07883.6 EFE38747.1 - 1.5e-19 69.2 0.6 6.6e-11 41.5 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 EFE38747.1 - 1.2e-06 27.7 0.1 0.0024 17.2 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Cupin_6 PF12852.2 EFE38747.1 - 0.0054 16.3 0.0 0.86 9.1 0.0 2.6 1 1 1 2 2 2 2 Cupin Sec62 PF03839.11 EFE38750.1 - 3.8e-52 176.9 7.8 1.7e-51 174.7 0.1 2.3 2 0 0 2 2 2 2 Translocation protein Sec62 Zip PF02535.17 EFE38750.1 - 0.00019 20.5 3.0 0.88 8.5 3.8 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter SinI PF08671.5 EFE38750.1 - 0.14 11.6 0.5 2.9 7.3 0.0 2.5 2 0 0 2 2 2 0 Anti-repressor SinI MSA-2c PF12238.3 EFE38750.1 - 9.9 5.7 22.5 0.24 11.0 2.3 2.3 2 0 0 2 2 2 0 Merozoite surface antigen 2c Lectin_C PF00059.16 EFE38751.1 - 0.00045 20.8 2.0 0.00083 19.9 0.3 2.2 2 0 0 2 2 2 1 Lectin C-type domain priB_priC PF07445.7 EFE38753.1 - 0.00068 19.1 1.8 0.0014 18.1 0.1 1.9 2 0 0 2 2 2 1 Primosomal replication protein priB and priC bZIP_1 PF00170.16 EFE38753.1 - 0.0062 16.4 0.2 0.0062 16.4 0.2 1.9 2 0 0 2 2 2 1 bZIP transcription factor Striatin PF08232.7 EFE38753.1 - 0.023 15.0 3.9 0.24 11.7 0.2 2.5 3 0 0 3 3 3 0 Striatin family DASH_Spc34 PF08657.5 EFE38753.1 - 0.5 9.9 6.7 1.9 8.0 0.3 2.3 2 0 0 2 2 2 0 DASH complex subunit Spc34 DUF2046 PF09755.4 EFE38753.1 - 0.5 9.1 9.2 0.063 12.1 3.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) DUF2968 PF11180.3 EFE38753.1 - 0.55 9.5 15.9 0.067 12.5 1.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2968) Spc24 PF08286.6 EFE38753.1 - 1.1 8.9 6.7 9.7 5.9 0.1 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.6 EFE38753.1 - 2.8 7.9 4.8 4.9 7.1 1.0 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) MerR-DNA-bind PF09278.6 EFE38753.1 - 6.4 7.2 11.7 0.73 10.2 0.3 2.4 2 0 0 2 2 2 0 MerR, DNA binding Carn_acyltransf PF00755.15 EFE38754.1 - 9e-183 608.5 0.0 1e-182 608.3 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Rxt3 PF08642.5 EFE38755.1 - 3.8e-27 94.8 0.0 1.3e-25 89.8 0.0 2.3 1 1 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.14 EFE38755.1 - 0.0001 22.2 0.0 0.0018 18.2 0.0 2.3 2 0 0 2 2 2 1 LCCL domain BAF1_ABF1 PF04684.8 EFE38757.1 - 3.5 6.3 23.8 5.1 5.8 16.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CLN3 PF02487.12 EFE38758.1 - 1.9e-96 323.3 17.3 5.7e-94 315.1 12.0 2.6 1 1 0 1 1 1 1 CLN3 protein Abhydrolase_3 PF07859.8 EFE38759.1 - 1.4e-33 116.2 0.0 5.3e-23 81.6 0.0 2.6 3 0 0 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 EFE38759.1 - 0.13 10.8 0.0 0.22 10.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) RP-C PF03428.8 EFE38759.1 - 0.14 11.5 0.1 0.28 10.6 0.1 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain Lipase_3 PF01764.20 EFE38759.1 - 0.15 11.6 0.0 0.36 10.4 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Aminotran_3 PF00202.16 EFE38760.1 - 6.1e-92 308.0 0.0 7.4e-92 307.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EFE38760.1 - 2.4e-05 23.4 0.0 8e-05 21.7 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II HMGL-like PF00682.14 EFE38761.1 - 8.1e-38 130.4 0.0 2.4e-37 128.8 0.0 1.7 1 1 0 1 1 1 1 HMGL-like Diphthamide_syn PF01866.12 EFE38762.1 - 7.6e-115 383.3 0.0 9.2e-115 383.0 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein BSP_II PF05432.6 EFE38762.1 - 0.13 11.5 9.1 0.19 10.9 6.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) ALMS_motif PF15309.1 EFE38762.1 - 0.28 11.0 3.4 0.45 10.3 2.4 1.3 1 0 0 1 1 1 0 ALMS motif Menin PF05053.8 EFE38762.1 - 0.82 7.7 4.9 1.1 7.2 3.4 1.1 1 0 0 1 1 1 0 Menin Daxx PF03344.10 EFE38762.1 - 1 7.7 8.2 1.3 7.4 5.7 1.1 1 0 0 1 1 1 0 Daxx Family DUF2890 PF11081.3 EFE38762.1 - 1.2 9.1 9.9 1.9 8.4 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) CDC27 PF09507.5 EFE38762.1 - 2.9 7.0 11.9 4 6.5 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 VID27 PF08553.5 EFE38762.1 - 3.6 5.6 6.3 4.6 5.3 4.4 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein Bromodomain PF00439.20 EFE38763.1 - 4.5e-14 52.1 0.0 2.2e-13 49.9 0.0 2.1 1 1 0 1 1 1 1 Bromodomain Sugarporin_N PF11471.3 EFE38764.1 - 0.12 12.0 1.0 0.22 11.1 0.7 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension OSCP PF00213.13 EFE38765.1 - 1.6e-42 145.2 1.7 2.3e-42 144.7 1.2 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Phage_portal PF04860.7 EFE38765.1 - 0.26 9.9 2.0 0.53 8.9 0.1 2.1 2 1 0 2 2 2 0 Phage portal protein Mob1_phocein PF03637.12 EFE38766.1 - 1.3e-70 236.6 0.1 1.6e-70 236.3 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family Rgp1 PF08737.5 EFE38767.1 - 8.1e-110 367.7 0.0 1.6e-109 366.7 0.0 1.5 1 0 0 1 1 1 1 Rgp1 Arrestin_N PF00339.24 EFE38767.1 - 0.0007 19.4 0.0 0.0022 17.8 0.0 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 EFE38767.1 - 0.0056 16.7 0.0 0.31 11.1 0.0 3.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Neugrin PF06413.6 EFE38768.1 - 1.2e-09 38.2 1.1 2.2e-09 37.5 0.7 1.4 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.2 EFE38768.1 - 1.4e-06 28.3 11.4 3.6e-06 27.0 7.9 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_DeoR PF08220.7 EFE38768.1 - 0.034 13.6 0.0 0.085 12.4 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain ICMT PF04140.9 EFE38769.1 - 1.6e-29 101.9 0.3 1.6e-29 101.9 0.2 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 EFE38769.1 - 1.2e-13 51.0 2.9 1.2e-13 51.0 2.0 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 EFE38769.1 - 2.3e-05 23.8 0.4 3.7e-05 23.1 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) K1 PF02960.9 EFE38769.1 - 0.071 13.1 0.3 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 K1 glycoprotein DUF4229 PF14012.1 EFE38769.1 - 3 7.7 7.0 13 5.8 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Cwf_Cwc_15 PF04889.7 EFE38771.1 - 1.8e-51 175.2 17.3 2.2e-51 174.9 12.0 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.4 EFE38771.1 - 0.00032 20.2 2.9 0.00044 19.8 2.0 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SDA1 PF05285.7 EFE38771.1 - 0.018 14.3 16.0 0.02 14.2 11.1 1.2 1 0 0 1 1 1 0 SDA1 DUF2890 PF11081.3 EFE38771.1 - 0.032 14.3 15.3 0.056 13.5 10.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) Phostensin_N PF13916.1 EFE38771.1 - 0.66 9.9 8.9 2.4 8.2 2.3 2.4 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal APG6 PF04111.7 EFE38771.1 - 1.2 8.1 8.9 1.5 7.7 6.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Nop14 PF04147.7 EFE38771.1 - 1.3 6.8 18.7 1.5 6.6 13.0 1.1 1 0 0 1 1 1 0 Nop14-like family IncA PF04156.9 EFE38771.1 - 3.6 7.1 7.8 5.1 6.6 5.4 1.3 1 0 0 1 1 1 0 IncA protein DUF3827 PF12877.2 EFE38771.1 - 5.5 4.9 8.0 7.1 4.5 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Glyco_hydro_16 PF00722.16 EFE38772.1 - 5.7e-11 42.0 0.3 1.2e-09 37.7 0.1 2.0 1 1 1 2 2 2 2 Glycosyl hydrolases family 16 Glyco_trans_2_3 PF13632.1 EFE38774.1 - 6.7e-44 149.9 0.4 6.7e-44 149.9 0.3 2.6 2 1 1 3 3 3 1 Glycosyl transferase family group 2 DUF3471 PF11954.3 EFE38774.1 - 0.008 15.9 0.0 0.024 14.4 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3471) WSC PF01822.14 EFE38775.1 - 5.5e-38 128.7 34.1 1.6e-19 69.5 9.4 2.5 2 0 0 2 2 2 2 WSC domain peroxidase PF00141.18 EFE38775.1 - 1.5e-22 80.2 0.2 2.9e-22 79.2 0.1 1.4 1 0 0 1 1 1 1 Peroxidase PSI_PSAK PF01241.13 EFE38775.1 - 0.012 15.6 0.1 0.036 14.0 0.0 1.8 1 0 0 1 1 1 0 Photosystem I psaG / psaK Flg_new PF09479.5 EFE38775.1 - 0.09 12.8 2.2 0.44 10.6 0.0 3.1 3 0 0 3 3 3 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) ABC_membrane PF00664.18 EFE38777.1 - 2.2e-75 253.6 39.0 2.6e-42 145.1 12.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE38777.1 - 1.6e-29 102.9 0.0 2.4e-26 92.6 0.0 3.4 2 1 0 2 2 2 1 ABC transporter SMC_N PF02463.14 EFE38777.1 - 3.1e-07 29.8 2.0 2.3e-05 23.7 1.4 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE38777.1 - 7.2e-06 26.1 0.3 0.00017 21.6 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE38777.1 - 0.00016 22.4 0.0 0.00041 21.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFE38777.1 - 0.0006 19.2 0.1 0.0017 17.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 EFE38777.1 - 0.00087 18.5 0.0 0.0026 16.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 EFE38777.1 - 0.00092 19.5 0.2 0.0023 18.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 EFE38777.1 - 0.001 17.8 0.0 0.0016 17.2 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 EFE38777.1 - 0.002 18.2 1.4 0.018 15.1 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.1 EFE38777.1 - 0.0028 16.7 0.0 0.005 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_16 PF13191.1 EFE38777.1 - 0.019 14.9 0.1 0.13 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 EFE38777.1 - 0.022 14.6 0.1 0.19 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_ATPase PF09818.4 EFE38777.1 - 0.023 13.3 0.0 0.18 10.3 0.0 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_25 PF13481.1 EFE38777.1 - 0.024 14.0 0.2 0.071 12.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 EFE38777.1 - 0.031 14.4 0.0 5.2 7.2 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EFE38777.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.1 EFE38777.1 - 0.27 9.7 8.4 0.039 12.5 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) NAD_binding_2 PF03446.10 EFE38778.1 - 3.3e-36 124.5 0.0 4.8e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EFE38778.1 - 1.9e-29 102.1 0.0 3e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 EFE38778.1 - 1.7e-07 31.5 0.0 5.6e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 EFE38778.1 - 8.4e-05 21.7 0.0 0.00014 21.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.17 EFE38778.1 - 0.00044 20.7 0.0 0.00092 19.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold MMS1_N PF10433.4 EFE38779.1 - 8.1e-77 258.4 0.0 2.3e-76 256.9 0.0 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 EFE38779.1 - 4.1e-40 137.8 0.1 4.3e-39 134.4 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region PQQ_2 PF13360.1 EFE38779.1 - 0.00023 20.6 0.0 0.034 13.6 0.0 3.0 3 0 0 3 3 3 1 PQQ-like domain PQQ_3 PF13570.1 EFE38779.1 - 0.032 14.5 0.3 4.1 7.8 0.2 4.3 3 0 0 3 3 3 0 PQQ-like domain Pkinase PF00069.20 EFE38780.1 - 2.2e-56 190.9 0.1 2.4e-55 187.5 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38780.1 - 9.3e-29 100.2 0.5 1.7e-20 73.1 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 EFE38780.1 - 2.7e-05 24.5 0.8 6.8e-05 23.3 0.5 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFE38780.1 - 6.9e-05 21.9 0.1 0.00045 19.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EFE38780.1 - 0.00064 19.5 4.1 0.21 11.2 0.1 3.4 1 1 2 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 EFE38780.1 - 0.043 12.8 0.0 0.24 10.4 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Abhydrolase_2 PF02230.11 EFE38781.1 - 3.1e-37 128.1 0.0 3.4e-37 127.9 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 EFE38781.1 - 2.9e-08 33.1 0.4 5.2e-06 25.8 0.0 2.1 1 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFE38781.1 - 2.8e-07 30.3 0.0 3.5e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 EFE38781.1 - 1.3e-06 27.8 0.0 1.7e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 EFE38781.1 - 7.9e-06 25.5 0.0 0.0053 16.3 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFE38781.1 - 0.0019 18.1 0.2 0.99 9.2 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Esterase PF00756.15 EFE38781.1 - 0.015 14.6 0.0 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 Putative esterase FSH1 PF03959.8 EFE38781.1 - 0.022 14.2 0.3 0.041 13.3 0.2 1.5 1 1 0 1 1 1 0 Serine hydrolase (FSH1) LIP PF03583.9 EFE38781.1 - 0.039 13.1 0.0 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 Secretory lipase DUF2920 PF11144.3 EFE38781.1 - 0.039 12.9 0.0 1.4 7.8 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2920) Lipase_3 PF01764.20 EFE38781.1 - 0.053 13.1 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Esterase_phd PF10503.4 EFE38781.1 - 0.079 12.2 0.0 0.5 9.5 0.0 1.9 2 0 0 2 2 2 0 Esterase PHB depolymerase Gal4_dimer PF03902.8 EFE38781.1 - 0.12 12.2 0.2 1.9 8.4 0.0 2.6 3 0 0 3 3 3 0 Gal4-like dimerisation domain Ctr PF04145.10 EFE38784.1 - 9.9e-14 51.6 0.0 1.8e-13 50.7 0.0 1.4 1 1 0 1 1 1 1 Ctr copper transporter family NAD_binding_6 PF08030.7 EFE38785.1 - 2.2e-19 69.8 0.0 3.4e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFE38785.1 - 5.8e-19 67.9 0.0 1.2e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 EFE38785.1 - 9.8e-15 54.7 11.1 2.8e-14 53.2 7.7 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 EFE38785.1 - 0.00036 20.6 0.0 0.00094 19.2 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EFE38785.1 - 0.022 15.3 0.0 2.6 8.6 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain FAD_binding_3 PF01494.14 EFE38786.1 - 2e-66 224.5 0.2 1.4e-41 142.7 0.0 2.1 1 1 1 2 2 2 2 FAD binding domain Phe_hydrox_dim PF07976.7 EFE38786.1 - 8.1e-22 77.6 0.0 1.3e-20 73.6 0.0 2.5 2 1 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain Trp_halogenase PF04820.9 EFE38786.1 - 0.07 11.7 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Nup35_RRM PF05172.8 EFE38787.1 - 0.0035 17.0 0.0 0.0064 16.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Abhydrolase_3 PF07859.8 EFE38789.1 - 3.6e-24 85.5 0.0 1.3e-23 83.7 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF2424 PF10340.4 EFE38789.1 - 7.5e-22 77.4 0.0 9.4e-22 77.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 EFE38789.1 - 0.00018 21.3 0.1 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFE38789.1 - 0.051 12.7 0.0 0.32 10.1 0.0 2.1 3 0 0 3 3 3 0 Prolyl oligopeptidase family DUF2974 PF11187.3 EFE38789.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Coatomer_E PF04733.9 EFE38790.1 - 7e-64 215.8 8.9 8e-64 215.6 6.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.1 EFE38790.1 - 5.4e-09 36.2 20.3 0.00066 19.9 2.1 4.6 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFE38790.1 - 7.4e-07 29.2 17.8 0.0012 19.2 0.0 5.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE38790.1 - 1.7e-06 28.5 21.5 0.00071 20.1 0.0 4.6 5 1 1 6 6 5 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE38790.1 - 7.3e-06 26.0 7.0 0.01 15.9 0.5 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EFE38790.1 - 0.0018 18.5 3.9 0.36 11.3 0.0 4.4 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE38790.1 - 0.0046 16.8 6.6 1.7 8.6 1.7 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF627 PF04781.7 EFE38790.1 - 0.0073 15.9 0.2 0.017 14.7 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF627) TPR_11 PF13414.1 EFE38790.1 - 0.014 15.0 6.8 0.064 12.9 0.0 3.9 3 1 1 4 4 4 0 TPR repeat Peptidase_S11 PF00768.15 EFE38790.1 - 0.021 14.1 0.2 0.028 13.6 0.1 1.3 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase TPR_9 PF13371.1 EFE38790.1 - 0.037 13.8 4.4 1.2 9.0 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFE38790.1 - 0.042 13.4 4.2 0.57 9.8 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFE38790.1 - 0.08 12.8 0.0 0.08 12.8 0.0 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_5 PF12688.2 EFE38790.1 - 0.24 11.4 5.2 1.9 8.5 1.5 2.6 2 1 0 2 2 2 0 Tetratrico peptide repeat TPR_4 PF07721.9 EFE38790.1 - 3.9 8.1 23.2 0.31 11.5 0.5 5.4 7 0 0 7 7 6 0 Tetratricopeptide repeat Fungal_trans PF04082.13 EFE38791.1 - 2.1e-09 36.6 0.1 3.4e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain APC_CDC26 PF10471.4 EFE38793.1 - 0.018 15.7 2.7 0.41 11.4 0.4 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex APC subunit 1 APH PF01636.18 EFE38794.1 - 1.3e-09 38.2 0.0 9.5e-09 35.3 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE38794.1 - 0.14 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.20 EFE38795.1 - 5.5e-12 45.3 0.0 1.7e-11 43.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38795.1 - 3.1e-09 36.2 0.0 4.7e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE38795.1 - 0.0013 18.4 0.1 0.049 13.3 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE38795.1 - 0.003 17.1 0.0 0.0075 15.8 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase AA_permease PF00324.16 EFE38797.1 - 1.8e-114 382.7 39.6 2.4e-114 382.3 27.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE38797.1 - 7e-30 103.8 45.6 1.1e-29 103.2 31.6 1.2 1 0 0 1 1 1 1 Amino acid permease F-box PF00646.28 EFE38798.1 - 5.4e-07 29.1 0.1 1.8e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE38798.1 - 2.6e-05 23.8 0.3 6e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like FTA4 PF13093.1 EFE38800.1 - 2.2e-58 197.1 0.9 6.7e-33 113.9 0.0 2.1 1 1 1 2 2 2 2 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF1664 PF07889.7 EFE38800.1 - 0.029 14.1 0.7 0.94 9.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) AAA_13 PF13166.1 EFE38800.1 - 0.04 12.3 1.0 0.059 11.8 0.2 1.5 1 1 0 1 1 1 0 AAA domain Peptidase_S46 PF10459.4 EFE38800.1 - 0.16 10.3 2.2 0.2 10.0 1.6 1.0 1 0 0 1 1 1 0 Peptidase S46 SlyX PF04102.7 EFE38801.1 - 0.068 13.5 0.6 0.73 10.2 0.2 2.5 2 0 0 2 2 2 0 SlyX HAUS6_N PF14661.1 EFE38801.1 - 0.38 10.0 4.5 12 5.2 3.2 2.2 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus RAP1 PF07218.6 EFE38801.1 - 9.1 4.2 7.8 12 3.8 5.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) HAD_2 PF13419.1 EFE38802.1 - 2.4e-14 53.9 0.0 4.9e-14 52.9 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE38802.1 - 0.0011 18.6 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Ribosomal_L18p PF00861.17 EFE38803.1 - 1.2e-43 148.1 0.3 2.3e-43 147.1 0.1 1.6 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 EFE38803.1 - 1.8e-32 111.7 2.7 1.8e-32 111.7 1.9 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region LRR_6 PF13516.1 EFE38804.1 - 0.005 16.7 3.7 36 4.8 0.0 6.9 8 0 0 8 8 8 1 Leucine Rich repeat DUF3135 PF11333.3 EFE38804.1 - 0.027 14.6 0.0 0.21 11.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) LRR_7 PF13504.1 EFE38804.1 - 2.9 8.4 6.3 1e+02 3.7 0.1 5.6 7 0 0 7 7 7 0 Leucine rich repeat ABC_membrane_2 PF06472.10 EFE38805.1 - 2.9e-109 364.5 1.5 4.1e-109 364.0 1.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EFE38805.1 - 1.3e-18 67.5 0.0 2.4e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EFE38805.1 - 0.00013 22.0 0.0 0.00032 20.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFE38805.1 - 0.0054 16.2 0.0 0.02 14.4 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.1 EFE38805.1 - 0.013 15.8 0.1 0.032 14.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.14 EFE38805.1 - 0.031 13.4 0.0 0.089 12.0 0.0 1.7 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EFE38805.1 - 0.036 14.0 0.1 0.12 12.3 0.1 1.8 1 0 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 EFE38805.1 - 0.091 11.9 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 RNA_helicase PF00910.17 EFE38805.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase p450 PF00067.17 EFE38806.1 - 9.1e-67 225.5 0.0 1.2e-66 225.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HTH_22 PF13309.1 EFE38807.1 - 0.14 11.9 0.0 0.27 10.9 0.0 1.7 1 1 0 1 1 1 0 HTH domain APH PF01636.18 EFE38809.1 - 3.9e-16 59.5 0.2 5.4e-16 59.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 EFE38809.1 - 0.00028 20.1 0.2 0.028 13.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Choline_kinase PF01633.15 EFE38809.1 - 0.00086 18.9 0.4 0.0013 18.3 0.3 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 EFE38809.1 - 0.0073 15.6 0.2 0.048 12.9 0.0 2.0 2 0 0 2 2 2 1 RIO1 family Phosphorylase PF00343.15 EFE38810.1 - 0 1074.7 0.1 0 1074.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Rsa3 PF14615.1 EFE38810.1 - 0.026 13.7 0.0 0.19 11.0 0.0 2.4 2 0 0 2 2 2 0 Ribosome-assembly protein 3 MyTH4 PF00784.12 EFE38811.1 - 0.096 12.6 0.2 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 MyTH4 domain TspO_MBR PF03073.10 EFE38812.1 - 0.0022 17.5 0.1 0.0026 17.2 0.0 1.1 1 0 0 1 1 1 1 TspO/MBR family KASH PF10541.4 EFE38812.1 - 3.8 7.4 10.1 1.1 9.1 3.4 2.2 2 1 0 2 2 2 0 Nuclear envelope localisation domain G-alpha PF00503.15 EFE38813.1 - 3.7e-55 187.2 0.3 4.8e-55 186.8 0.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EFE38813.1 - 5.1e-08 32.3 0.3 1e-07 31.4 0.2 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family RNA_pol PF00940.14 EFE38814.1 - 6.3e-164 545.2 0.0 1.1e-163 544.5 0.0 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 EFE38814.1 - 9.7e-80 268.1 0.8 1.6e-79 267.5 0.6 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Sin_N PF04801.8 EFE38815.1 - 2.7e-30 105.6 2.0 6.9e-29 100.9 1.4 2.0 1 1 0 1 1 1 1 Sin-like protein conserved region DUF2615 PF11027.3 EFE38816.1 - 0.19 11.6 0.0 0.19 11.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) ATP-synt_S1 PF05827.7 EFE38817.1 - 7.5e-40 137.0 0.2 2.3e-39 135.4 0.1 1.6 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Nop25 PF09805.4 EFE38818.1 - 1.2e-37 129.0 11.0 1.2e-37 129.0 7.6 3.0 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) Nop53 PF07767.6 EFE38818.1 - 5.9 5.7 38.4 0.97 8.3 4.7 2.3 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Tropomyosin_1 PF12718.2 EFE38819.1 - 6.9e-46 155.6 35.8 8.9e-46 155.2 24.8 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.15 EFE38819.1 - 4.7e-10 38.9 36.1 4e-06 26.0 10.7 2.1 1 1 1 2 2 2 2 Tropomyosin GAS PF13851.1 EFE38819.1 - 3.6e-05 23.0 31.9 7.7e-05 21.9 14.7 2.1 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding KLRAQ PF10205.4 EFE38819.1 - 0.001 19.0 11.5 0.001 19.0 8.0 2.9 1 1 1 2 2 2 1 Predicted coiled-coil domain-containing protein Spc7 PF08317.6 EFE38819.1 - 0.0019 16.9 28.1 0.033 12.8 6.6 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein AAA_13 PF13166.1 EFE38819.1 - 0.0027 16.2 21.2 0.0034 15.9 14.7 1.1 1 0 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.4 EFE38819.1 - 0.0031 17.3 6.3 0.0031 17.3 4.4 3.3 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.7 EFE38819.1 - 0.0082 15.8 7.9 0.0082 15.8 5.5 2.1 1 1 1 2 2 2 1 Laminin Domain II Meckelin PF09773.4 EFE38819.1 - 0.018 12.8 0.9 0.022 12.5 0.6 1.1 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) Sugarporin_N PF11471.3 EFE38819.1 - 0.025 14.2 2.6 0.025 14.2 1.8 3.5 3 2 1 4 4 3 0 Maltoporin periplasmic N-terminal extension TMP_2 PF06791.8 EFE38819.1 - 0.025 14.2 3.7 0.02 14.5 1.9 1.4 1 1 0 1 1 1 0 Prophage tail length tape measure protein ADIP PF11559.3 EFE38819.1 - 0.044 13.6 33.5 0.26 11.1 7.4 3.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 EFE38819.1 - 0.058 12.9 33.4 53 3.3 23.1 2.2 1 1 0 1 1 1 0 IncA protein HATPase_c_2 PF13581.1 EFE38819.1 - 0.063 13.0 1.2 0.11 12.2 0.9 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Mod_r PF07200.8 EFE38819.1 - 0.14 12.0 28.0 0.4 10.5 13.6 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF3584 PF12128.3 EFE38819.1 - 0.16 9.2 28.5 0.2 8.9 19.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.6 EFE38819.1 - 0.22 11.3 30.6 2 8.1 6.1 2.7 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Atg14 PF10186.4 EFE38819.1 - 0.25 10.2 29.8 0.21 10.4 15.2 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TPR_MLP1_2 PF07926.7 EFE38819.1 - 0.27 10.9 35.0 1.1 8.9 5.5 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein ERM PF00769.14 EFE38819.1 - 0.43 10.0 37.5 0.091 12.2 11.8 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family BLOC1_2 PF10046.4 EFE38819.1 - 0.49 10.5 22.9 1.1 9.3 1.7 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.7 EFE38819.1 - 0.52 9.4 4.5 2.6 7.1 0.2 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein bZIP_1 PF00170.16 EFE38819.1 - 0.75 9.7 24.9 1.3 9.0 0.6 4.0 1 1 3 4 4 4 0 bZIP transcription factor TMF_DNA_bd PF12329.3 EFE38819.1 - 0.94 9.3 37.1 0.38 10.6 10.7 3.2 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.7 EFE38819.1 - 0.96 9.2 16.2 0.6 9.9 2.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3340 PF11818.3 EFE38819.1 - 1 9.3 24.5 20 5.1 17.0 2.0 1 1 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) PilJ PF13675.1 EFE38819.1 - 1.4 9.3 14.8 2.9 8.2 4.3 2.8 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF3287 PF11690.3 EFE38819.1 - 1.4 9.0 10.9 42 4.2 7.0 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) DUF972 PF06156.8 EFE38819.1 - 1.9 8.9 27.4 0.6 10.4 7.9 2.9 1 1 1 2 2 1 0 Protein of unknown function (DUF972) APG6 PF04111.7 EFE38819.1 - 2.1 7.3 34.8 2.2 7.2 13.2 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 Orbi_VP5 PF00901.12 EFE38819.1 - 3.6 5.6 20.9 4.5 5.3 14.5 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Cep57_MT_bd PF06657.8 EFE38819.1 - 4.5 7.2 20.7 0.16 11.9 2.6 3.7 1 1 3 4 4 4 0 Centrosome microtubule-binding domain of Cep57 IFT46_B_C PF12317.3 EFE38819.1 - 4.6 6.5 9.6 1 8.6 4.0 1.7 1 1 1 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal DUF4200 PF13863.1 EFE38819.1 - 4.7 7.1 36.2 2.3 8.2 15.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) BRCA-2_OB3 PF09104.5 EFE38819.1 - 4.8 6.9 6.3 14 5.4 0.1 3.1 1 1 3 4 4 4 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 DUF812 PF05667.6 EFE38819.1 - 5.4 5.3 29.5 16 3.8 14.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Fib_alpha PF08702.5 EFE38819.1 - 5.7 7.0 20.5 36 4.4 8.7 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FUSC PF04632.7 EFE38819.1 - 6.4 5.0 7.4 7.5 4.8 5.1 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Syntaxin-6_N PF09177.6 EFE38819.1 - 6.7 7.1 21.6 30 5.1 6.8 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Mnd1 PF03962.10 EFE38819.1 - 6.9 6.2 32.0 15 5.2 12.1 2.1 1 1 1 2 2 2 0 Mnd1 family Uds1 PF15456.1 EFE38819.1 - 9.5 6.2 28.3 21 5.1 15.0 3.0 1 1 1 2 2 2 0 Up-regulated During Septation CMAS PF02353.15 EFE38821.1 - 8.7e-59 198.8 0.0 1.1e-58 198.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 EFE38821.1 - 2.3e-11 43.6 0.0 6.9e-11 42.1 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE38821.1 - 4.2e-07 30.3 0.0 8.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38821.1 - 0.002 18.5 0.0 0.0046 17.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38821.1 - 0.0032 18.0 0.0 0.007 16.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE38821.1 - 0.0062 16.5 0.0 0.022 14.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.8 EFE38821.1 - 0.011 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.9 EFE38821.1 - 0.022 14.1 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.1 EFE38821.1 - 0.024 14.2 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38821.1 - 0.086 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EFE38821.1 - 0.18 11.3 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AMP-binding PF00501.23 EFE38822.1 - 3.2e-38 131.1 0.0 3.9e-38 130.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.23 EFE38823.1 - 1.9e-35 122.1 0.0 2.3e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE38823.1 - 1.5e-13 51.5 0.0 2.2e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SBF PF01758.11 EFE38826.1 - 2.1e-23 82.7 18.7 3.1e-22 78.9 3.7 3.3 2 2 1 3 3 3 2 Sodium Bile acid symporter family ATP_bind_3 PF01171.15 EFE38827.1 - 2.7e-19 69.3 0.0 4.2e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 PP-loop family DUF2392 PF10288.4 EFE38827.1 - 0.003 17.8 0.0 0.0069 16.6 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2392) RecR PF02132.10 EFE38827.1 - 0.013 14.9 1.2 0.013 14.9 0.9 2.4 3 0 0 3 3 3 0 RecR protein tRNA_Me_trans PF03054.11 EFE38827.1 - 0.017 13.7 0.0 0.026 13.1 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase zf-UBR PF02207.15 EFE38827.1 - 0.074 12.7 7.1 0.35 10.6 0.6 2.5 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Acetyltransf_8 PF13523.1 EFE38828.1 - 2.2e-32 112.0 0.0 3.1e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain WRC PF08879.5 EFE38829.1 - 0.019 14.5 1.3 0.036 13.7 0.1 1.9 2 0 0 2 2 2 0 WRC zf-DHHC PF01529.15 EFE38831.1 - 4.8e-18 65.1 10.1 4.8e-18 65.1 7.0 2.2 1 1 1 2 2 2 1 DHHC palmitoyltransferase FUSC_2 PF13515.1 EFE38831.1 - 0.0049 16.7 0.3 0.0049 16.7 0.2 1.9 2 0 0 2 2 2 1 Fusaric acid resistance protein-like TrbL PF04610.9 EFE38831.1 - 4.3 6.9 10.2 0.58 9.8 1.7 2.0 2 0 0 2 2 2 0 TrbL/VirB6 plasmid conjugal transfer protein Glyco_hydro_17 PF00332.13 EFE38833.1 - 6.3e-08 32.0 1.4 0.00017 20.7 0.6 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 Pax2_C PF12403.3 EFE38836.1 - 0.017 14.7 1.1 0.026 14.1 0.7 1.2 1 0 0 1 1 1 0 Paired-box protein 2 C terminal Requiem_N PF14051.1 EFE38836.1 - 0.13 12.1 5.1 0.26 11.2 3.5 1.5 1 1 0 1 1 1 0 N-terminal domain of DPF2/REQ. Androgen_recep PF02166.11 EFE38836.1 - 2.4 6.9 7.0 3.3 6.4 4.9 1.1 1 0 0 1 1 1 0 Androgen receptor DUF2207 PF09972.4 EFE38837.1 - 0.0011 17.6 2.6 0.0033 16.0 0.7 2.3 2 1 0 2 2 2 1 Predicted membrane protein (DUF2207) DUF2628 PF10947.3 EFE38837.1 - 0.0035 17.1 4.5 0.12 12.1 1.9 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2628) DUF912 PF06024.7 EFE38837.1 - 0.0066 16.4 1.1 2.7 8.1 0.0 3.1 2 1 1 3 3 3 2 Nucleopolyhedrovirus protein of unknown function (DUF912) ATG27 PF09451.5 EFE38837.1 - 0.021 14.0 3.6 0.22 10.7 0.4 2.6 2 1 1 3 3 3 0 Autophagy-related protein 27 DUF4328 PF14219.1 EFE38837.1 - 0.32 10.2 1.5 6.5 6.0 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4328) ATP-synt_E PF05680.7 EFE38837.1 - 3.1 7.7 7.3 19 5.2 1.6 2.6 2 1 0 2 2 2 0 ATP synthase E chain Mating_C PF12737.2 EFE38838.1 - 0.11 11.3 1.1 0.16 10.8 0.7 1.2 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 HECT_2 PF09814.4 EFE38840.1 - 1.4e-13 50.3 0.0 1.5e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF4243 PF14027.1 EFE38842.1 - 2.7e-81 273.5 0.8 3.2e-81 273.3 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) TPR_10 PF13374.1 EFE38843.1 - 4.3e-47 156.7 20.2 3.7e-12 45.7 0.1 7.7 7 1 0 7 7 7 6 Tetratricopeptide repeat TPR_12 PF13424.1 EFE38843.1 - 5.3e-41 138.4 18.3 3e-17 62.3 0.9 5.3 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.12 EFE38843.1 - 5.1e-14 50.9 17.7 0.00032 20.3 0.1 6.3 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.1 EFE38843.1 - 9.7e-13 47.5 18.4 0.00024 20.6 3.3 5.2 4 1 1 5 5 5 5 TPR repeat TPR_16 PF13432.1 EFE38843.1 - 2.9e-10 40.5 12.5 0.024 15.2 0.0 5.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFE38843.1 - 1.9e-09 36.6 19.8 0.00077 19.0 0.0 7.6 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFE38843.1 - 2.1e-09 36.5 15.6 4.1e-05 23.0 0.2 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE38843.1 - 5.2e-08 32.9 3.0 3.2e-05 23.9 0.1 3.6 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 EFE38843.1 - 6e-05 22.9 6.2 0.72 10.1 0.1 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat Rab5-bind PF09311.6 EFE38843.1 - 6.2e-05 22.9 0.6 0.094 12.5 0.2 3.2 2 2 1 3 3 3 1 Rabaptin-like protein TPR_14 PF13428.1 EFE38843.1 - 7.9e-05 22.9 14.4 4 8.3 0.1 6.2 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.9 EFE38843.1 - 0.00015 21.8 3.1 0.93 10.1 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE38843.1 - 0.004 16.8 11.7 14 5.7 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF2989 PF11207.3 EFE38843.1 - 0.062 12.7 2.8 0.12 11.7 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2989) DUF627 PF04781.7 EFE38843.1 - 0.075 12.6 0.1 5.7 6.5 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF627) TPR_19 PF14559.1 EFE38843.1 - 0.12 12.7 13.1 0.83 10.0 0.7 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 EFE38843.1 - 0.52 9.5 4.5 3.5 6.9 0.1 3.8 3 1 0 3 3 3 0 SHNi-TPR AAA PF00004.24 EFE38844.1 - 1e-49 168.1 0.0 3.1e-43 147.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE38844.1 - 2.1e-07 31.7 0.0 0.00098 19.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFE38844.1 - 3.8e-05 23.1 0.1 0.00032 20.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 EFE38844.1 - 8.9e-05 21.6 0.0 0.00032 19.8 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFE38844.1 - 0.00018 21.6 0.0 0.0059 16.7 0.0 3.2 3 2 1 4 4 3 1 AAA domain AAA_16 PF13191.1 EFE38844.1 - 0.00023 21.2 1.5 0.023 14.6 0.0 3.8 2 2 0 3 3 3 1 AAA ATPase domain Parvo_NS1 PF01057.12 EFE38844.1 - 0.00034 19.5 0.0 0.0006 18.7 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RNA_helicase PF00910.17 EFE38844.1 - 0.00042 20.4 0.1 0.0096 16.0 0.0 2.8 3 0 0 3 3 2 1 RNA helicase IstB_IS21 PF01695.12 EFE38844.1 - 0.001 18.5 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.11 EFE38844.1 - 0.0016 17.7 0.0 0.064 12.4 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_2 PF07724.9 EFE38844.1 - 0.0016 18.3 0.0 0.0049 16.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EFE38844.1 - 0.0023 17.8 0.0 0.21 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE38844.1 - 0.0036 17.0 0.0 0.02 14.6 0.0 2.4 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 EFE38844.1 - 0.0038 16.0 0.0 0.0068 15.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_18 PF13238.1 EFE38844.1 - 0.0052 17.0 0.0 0.071 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EFE38844.1 - 0.011 15.4 0.0 0.056 13.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 EFE38844.1 - 0.013 14.6 0.1 0.031 13.4 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI KaiC PF06745.8 EFE38844.1 - 0.019 14.0 0.0 0.051 12.6 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_14 PF13173.1 EFE38844.1 - 0.023 14.6 0.0 0.21 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 EFE38844.1 - 0.052 13.5 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EFE38844.1 - 0.097 12.2 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain PPV_E1_C PF00519.12 EFE38844.1 - 0.19 10.2 0.0 0.3 9.6 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase W2 PF02020.13 EFE38845.1 - 2.2e-13 49.9 10.1 2.2e-13 49.9 7.0 3.4 3 1 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.19 EFE38845.1 - 3.2e-10 39.0 12.4 2.1e-06 26.9 2.5 3.8 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFE38845.1 - 0.00055 19.4 4.0 0.00055 19.4 2.8 2.8 2 1 1 3 3 3 1 Hexapeptide repeat of succinyl-transferase NTP_transferase PF00483.18 EFE38845.1 - 0.019 14.2 0.0 0.039 13.2 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase IBR PF01485.16 EFE38846.1 - 1.1e-22 79.6 46.9 5.4e-12 45.3 3.9 4.4 3 1 1 4 4 4 3 IBR domain zf-C3HC4_2 PF13923.1 EFE38846.1 - 6.3e-06 26.1 7.8 6.3e-06 26.1 5.4 4.6 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) UN_NPL4 PF11543.3 EFE38846.1 - 0.00063 19.9 0.0 0.0011 19.1 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-RING_2 PF13639.1 EFE38846.1 - 0.00082 19.1 8.0 0.00082 19.1 5.5 3.6 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4 PF00097.20 EFE38846.1 - 0.0013 18.3 5.4 0.0013 18.3 3.7 4.6 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE38846.1 - 0.0028 17.3 9.2 0.0028 17.3 6.4 3.2 3 0 0 3 3 3 2 zinc-RING finger domain AceK PF06315.6 EFE38846.1 - 0.062 11.5 0.2 0.086 11.1 0.1 1.1 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) Mito_carr PF00153.22 EFE38847.1 - 6.6e-26 89.8 1.4 2e-23 81.8 0.1 2.0 1 1 1 2 2 2 2 Mitochondrial carrier protein tRNA-synt_1 PF00133.17 EFE38848.1 - 1.1e-35 122.8 0.0 1.9e-25 88.9 0.0 3.6 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EFE38848.1 - 9.4e-17 60.7 0.0 3.9e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EFE38848.1 - 2.8e-11 43.3 0.0 7.3e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 EFE38848.1 - 2.9e-07 29.9 0.0 6.2e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 EFE38848.1 - 0.016 13.8 0.0 0.1 11.2 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (K) HD_3 PF13023.1 EFE38849.1 - 0.025 14.3 1.0 0.031 14.0 0.7 1.2 1 0 0 1 1 1 0 HD domain DUF1675 PF07897.6 EFE38849.1 - 0.047 13.5 1.0 0.054 13.3 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) LRS4 PF10422.4 EFE38849.1 - 0.086 12.1 3.1 0.1 11.9 2.1 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 L51_S25_CI-B8 PF05047.11 EFE38849.1 - 0.089 12.5 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain PFK PF00365.15 EFE38849.1 - 0.12 11.3 0.4 0.13 11.2 0.3 1.1 1 0 0 1 1 1 0 Phosphofructokinase DUF2774 PF11242.3 EFE38849.1 - 0.92 9.5 5.0 0.29 11.1 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2774) DUF1751 PF08551.5 EFE38850.1 - 2e-28 98.5 0.5 4.3e-28 97.5 0.3 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 EFE38850.1 - 9.5e-06 25.6 11.3 9.5e-06 25.6 7.9 1.6 2 0 0 2 2 2 1 Rhomboid family WD40 PF00400.27 EFE38851.1 - 2.2e-08 33.6 4.2 0.013 15.3 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat eIF2A PF08662.6 EFE38851.1 - 0.032 13.9 0.0 0.18 11.5 0.0 2.1 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Phlebovirus_NSM PF07246.6 EFE38852.1 - 0.0074 15.4 0.6 0.01 14.9 0.4 1.2 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M WD40_alt PF14077.1 EFE38852.1 - 0.14 11.8 1.9 0.17 11.5 0.3 2.0 2 0 0 2 2 2 0 Alternative WD40 repeat motif CorA PF01544.13 EFE38852.1 - 3 6.7 5.8 24 3.8 4.0 2.1 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Chorismate_bind PF00425.13 EFE38853.1 - 1.2e-89 300.1 0.0 1.6e-89 299.6 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 EFE38853.1 - 3.1e-27 95.3 0.0 1.1e-23 83.8 0.0 3.9 4 1 1 5 5 5 2 Anthranilate synthase component I, N terminal region ENTH PF01417.15 EFE38854.1 - 5.5e-30 103.8 0.4 8.4e-30 103.2 0.3 1.3 1 0 0 1 1 1 1 ENTH domain UIM PF02809.15 EFE38854.1 - 0.29 10.8 5.9 0.42 10.2 0.7 2.8 2 0 0 2 2 2 0 Ubiquitin interaction motif Pkinase PF00069.20 EFE38855.1 - 1.5e-07 30.8 0.0 7e-07 28.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38855.1 - 0.00015 20.9 0.0 0.00055 19.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase HEAT PF02985.17 EFE38857.1 - 3.8e-08 32.7 1.4 0.19 11.8 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.1 EFE38857.1 - 4.3e-08 33.3 0.1 0.0017 18.6 0.2 4.0 2 1 2 4 4 4 2 HEAT repeats Adaptin_N PF01602.15 EFE38857.1 - 2.9e-05 22.5 1.0 0.00053 18.4 0.7 2.9 1 1 0 1 1 1 1 Adaptin N terminal region TPR_MLP1_2 PF07926.7 EFE38857.1 - 0.0022 17.7 0.4 0.0022 17.7 0.3 2.9 3 0 0 3 3 3 1 TPR/MLP1/MLP2-like protein IncA PF04156.9 EFE38857.1 - 0.035 13.7 14.0 0.016 14.8 6.9 2.2 2 0 0 2 2 2 0 IncA protein V_ATPase_I PF01496.14 EFE38857.1 - 0.058 11.2 3.3 0.088 10.6 2.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HEAT_EZ PF13513.1 EFE38857.1 - 0.066 13.7 0.8 4.4 7.9 0.3 3.7 4 1 0 4 4 3 0 HEAT-like repeat Spc7 PF08317.6 EFE38857.1 - 0.072 11.7 9.0 0.13 10.8 6.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.7 EFE38857.1 - 0.085 11.8 11.9 0.2 10.6 8.3 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 Macoilin PF09726.4 EFE38857.1 - 0.13 10.4 7.8 0.25 9.6 5.4 1.3 1 0 0 1 1 1 0 Transmembrane protein HAUS-augmin3 PF14932.1 EFE38857.1 - 0.39 9.8 9.3 0.091 11.9 4.0 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 HsbA PF12296.3 EFE38857.1 - 0.49 10.2 4.4 3.8 7.3 0.1 4.0 4 0 0 4 4 4 0 Hydrophobic surface binding protein A AAA_13 PF13166.1 EFE38857.1 - 2.6 6.3 8.0 0.35 9.2 1.9 1.8 2 0 0 2 2 2 0 AAA domain NYD-SP28_assoc PF14775.1 EFE38857.1 - 2.9 7.6 5.4 4.9 6.9 0.6 2.8 1 1 1 2 2 2 0 Sperm tail C-terminal domain HALZ PF02183.13 EFE38857.1 - 4.1 7.2 7.6 0.75 9.5 1.5 2.7 2 1 0 2 2 2 0 Homeobox associated leucine zipper Latarcin PF10279.4 EFE38857.1 - 7 6.9 7.8 5.6 7.2 3.1 2.5 3 0 0 3 3 3 0 Latarcin precursor TMF_DNA_bd PF12329.3 EFE38857.1 - 8.9 6.1 15.3 2.6 7.9 3.2 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding GAS PF13851.1 EFE38857.1 - 9.7 5.3 15.2 1.5 7.9 6.4 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Ribosomal_L7Ae PF01248.21 EFE38858.1 - 4.7e-21 74.1 0.3 7.9e-21 73.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RhoGAP PF00620.22 EFE38859.1 - 2e-39 134.6 0.0 4.6e-39 133.4 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.24 EFE38859.1 - 3e-12 46.6 0.2 1.1e-11 44.8 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 EFE38859.1 - 1.1e-07 32.1 0.0 4.3e-07 30.1 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 EFE38859.1 - 0.01 15.8 0.1 0.035 14.1 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain R_equi_Vir PF05526.6 EFE38859.1 - 0.013 15.1 0.8 0.055 13.1 0.6 2.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DivIC PF04977.10 EFE38859.1 - 3.3 7.2 6.0 34 4.0 4.0 2.9 2 0 0 2 2 2 0 Septum formation initiator Erv26 PF04148.8 EFE38860.1 - 2.8e-83 278.4 0.8 3.7e-81 271.5 0.5 2.1 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 WBS_methylT PF12589.3 EFE38861.1 - 8.6e-18 64.6 3.5 1.5e-17 63.8 2.5 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 EFE38861.1 - 2.1e-11 44.1 0.0 3.6e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38861.1 - 9.1e-08 32.3 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38861.1 - 2.2e-06 27.3 0.0 3.3e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38861.1 - 2.5e-05 24.6 0.0 6.1e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38861.1 - 4.4e-05 24.0 0.0 0.0001 22.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38861.1 - 4.9e-05 23.0 0.0 7.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE38861.1 - 0.0003 20.8 0.0 0.00064 19.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EFE38861.1 - 0.00048 19.7 0.0 0.00089 18.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 EFE38861.1 - 0.0019 17.3 0.0 0.016 14.2 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 EFE38861.1 - 0.032 13.3 0.0 0.39 9.7 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase ACT_7 PF13840.1 EFE38861.1 - 0.16 11.4 0.1 0.34 10.4 0.1 1.5 1 0 0 1 1 1 0 ACT domain Iso_dh PF00180.15 EFE38862.1 - 8.4e-84 281.4 0.0 1e-83 281.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PhrC_PhrF PF11131.3 EFE38863.1 - 0.12 12.0 3.3 0.17 11.4 2.3 1.3 1 0 0 1 1 1 0 Rap-phr extracellular signalling DUF3485 PF11984.3 EFE38863.1 - 0.16 11.0 2.2 0.16 11.0 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3485) Proteasome PF00227.21 EFE38865.1 - 3.9e-45 153.4 0.2 7.7e-32 110.1 0.0 2.7 3 0 0 3 3 3 2 Proteasome subunit Proteasome_A_N PF10584.4 EFE38865.1 - 0.033 13.5 0.2 0.033 13.5 0.1 1.7 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Nucleoplasmin PF03066.10 EFE38865.1 - 0.31 10.5 12.6 0.47 9.9 8.8 1.4 1 0 0 1 1 1 0 Nucleoplasmin Med17 PF10156.4 EFE38865.1 - 1.5 7.0 7.8 1.8 6.7 5.4 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex DUF2457 PF10446.4 EFE38865.1 - 2.1 7.0 20.4 3.2 6.3 14.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.1 EFE38865.1 - 2.6 8.4 14.4 4.7 7.5 10.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 PF15387.1 EFE38865.1 - 3.3 7.9 11.5 6 7.0 7.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DMRL_synthase PF00885.14 EFE38866.1 - 7e-45 152.2 0.0 8.5e-45 151.9 0.0 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase SIS PF01380.17 EFE38867.1 - 1.5e-53 179.8 0.0 1.1e-29 102.7 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 EFE38867.1 - 6.4e-22 77.7 0.1 2.4e-19 69.2 0.0 2.5 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EFE38867.1 - 1.5e-19 70.3 0.0 3e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EFE38867.1 - 3.6e-12 46.0 0.0 7.6e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 EFE38867.1 - 1.2e-07 30.6 0.0 2.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 EFE38867.1 - 0.0083 15.8 0.0 0.56 9.9 0.0 2.6 2 0 0 2 2 2 1 SIS domain DUF1673 PF07895.6 EFE38867.1 - 0.091 12.2 0.5 0.16 11.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) CDC45 PF02724.9 EFE38868.1 - 0.007 14.4 4.2 0.0087 14.1 2.9 1.1 1 0 0 1 1 1 1 CDC45-like protein DBINO PF13892.1 EFE38868.1 - 0.041 13.9 0.3 0.041 13.9 0.2 2.1 2 0 0 2 2 2 0 DNA-binding domain PBP1_TM PF14812.1 EFE38868.1 - 1.1 9.5 10.5 2.8 8.2 7.3 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF724 PF05266.9 EFE38868.1 - 1.8 8.1 5.2 2.4 7.7 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Pkinase PF00069.20 EFE38870.1 - 1.1e-69 234.4 0.0 1.8e-69 233.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38870.1 - 5.5e-51 173.1 0.0 1.1e-50 172.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PH_11 PF15413.1 EFE38870.1 - 5.4e-24 84.6 0.8 1.3e-23 83.3 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PBD PF00786.23 EFE38870.1 - 3e-23 82.0 0.8 1.2e-22 80.0 0.0 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain PH PF00169.24 EFE38870.1 - 3.6e-07 30.3 0.1 7.5e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 EFE38870.1 - 8.4e-06 24.9 0.0 1.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EFE38870.1 - 0.032 13.0 0.1 0.053 12.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 EFE38870.1 - 0.75 9.4 6.1 0.11 12.1 0.2 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family NAD_kinase PF01513.16 EFE38871.1 - 4.6e-49 166.7 0.1 6.6e-49 166.2 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase Acyltransferase PF01553.16 EFE38872.1 - 4.7e-27 94.0 0.0 7.3e-27 93.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase TPR_2 PF07719.12 EFE38873.1 - 1.6e-26 90.0 18.2 0.0033 17.2 0.1 12.5 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_11 PF13414.1 EFE38873.1 - 3.2e-24 84.3 42.1 3.9e-06 26.4 0.1 11.6 9 3 2 12 12 11 6 TPR repeat TPR_1 PF00515.23 EFE38873.1 - 9.8e-23 78.7 19.9 0.0011 18.4 0.1 11.6 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_19 PF14559.1 EFE38873.1 - 3.6e-20 72.0 28.5 1.1e-05 25.6 0.0 9.2 10 1 1 11 11 9 4 Tetratricopeptide repeat TPR_8 PF13181.1 EFE38873.1 - 2.6e-18 64.3 19.0 0.035 13.8 0.0 11.0 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_12 PF13424.1 EFE38873.1 - 5.2e-18 64.7 29.0 2.2e-05 24.2 0.5 10.4 9 1 1 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.1 EFE38873.1 - 1.8e-17 62.2 32.1 0.0015 19.0 0.0 13.0 14 1 1 15 15 12 5 Tetratricopeptide repeat TPR_16 PF13432.1 EFE38873.1 - 4e-15 56.0 37.0 2.4e-05 24.8 0.1 11.1 10 2 3 13 13 13 4 Tetratricopeptide repeat TPR_6 PF13174.1 EFE38873.1 - 4.2e-08 33.1 28.8 0.015 15.6 0.1 12.3 15 0 0 15 15 13 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFE38873.1 - 2.6e-06 27.2 20.5 0.13 12.5 0.0 10.6 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE38873.1 - 2.5e-05 23.7 30.3 0.2 11.5 0.2 9.7 11 0 0 11 11 8 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE38873.1 - 7.2e-05 22.8 23.0 0.53 10.4 0.0 7.9 8 1 0 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.9 EFE38873.1 - 0.028 14.8 2.1 18 6.0 0.0 4.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFE38873.1 - 6.6 6.8 18.4 5.3 7.1 0.1 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat SGL PF08450.7 EFE38874.1 - 1.6e-26 93.1 0.4 1.8e-13 50.4 0.0 2.2 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.11 EFE38874.1 - 0.0033 17.4 0.1 0.073 13.1 0.0 3.1 3 1 0 3 3 3 1 Strictosidine synthase Arylesterase PF01731.15 EFE38874.1 - 0.1 12.6 0.0 0.5 10.3 0.0 2.1 2 0 0 2 2 2 0 Arylesterase SRP72 PF08492.7 EFE38878.1 - 4e-14 52.7 4.9 1.2e-13 51.2 3.4 1.8 1 0 0 1 1 1 1 SRP72 RNA-binding domain Apc3 PF12895.2 EFE38878.1 - 5.5e-05 23.2 6.3 12 6.1 0.0 5.5 3 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 EFE38878.1 - 0.00022 21.4 7.4 0.13 12.6 0.0 5.1 3 2 2 6 6 6 1 Tetratricopeptide repeat TPR_20 PF14561.1 EFE38878.1 - 0.0019 18.2 1.1 1.9 8.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE38878.1 - 0.0066 16.1 0.7 11 6.1 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE38878.1 - 0.16 11.9 9.9 11 6.1 1.5 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFE38878.1 - 0.18 11.7 6.0 3.3 7.7 0.2 4.6 5 2 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.1 EFE38878.1 - 3.8 7.4 5.8 3.8 7.4 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFE38878.1 - 3.8 7.2 6.4 83 3.0 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Homeobox_KN PF05920.6 EFE38879.1 - 1.1e-09 37.7 0.2 3.3e-09 36.3 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain HSP70 PF00012.15 EFE38882.1 - 3.7e-61 206.8 21.0 4.4e-61 206.5 2.0 3.2 3 1 0 3 3 3 2 Hsp70 protein Herpes_capsid PF06112.6 EFE38882.1 - 0.11 12.5 16.2 0.26 11.3 3.4 2.9 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein MFS_1 PF07690.11 EFE38883.1 - 6e-24 84.4 59.8 1.5e-22 79.7 40.4 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE38883.1 - 4.1e-06 25.6 13.4 4.1e-06 25.6 9.3 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter tRNA-synt_1c PF00749.16 EFE38885.1 - 7.6e-94 313.8 0.0 1.1e-93 313.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EFE38885.1 - 1.2e-29 103.2 0.0 3.3e-29 101.7 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain ATP-grasp_4 PF13535.1 EFE38887.1 - 1.2e-23 83.8 0.0 1.3e-20 73.9 0.0 2.8 3 1 0 3 3 3 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFE38887.1 - 3.6e-07 29.7 0.0 6.3e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 EFE38887.1 - 9.6e-06 24.5 0.0 0.051 12.3 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 EFE38887.1 - 5.3e-05 23.1 0.0 0.0034 17.2 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain GDPD PF03009.12 EFE38889.1 - 1.6e-39 136.0 0.0 5.4e-39 134.2 0.0 1.8 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.2 EFE38889.1 - 1.9e-17 63.3 0.0 1.7e-08 34.7 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFE38889.1 - 1.2e-13 50.1 0.2 3.1e-05 23.5 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 EFE38889.1 - 2.9e-13 49.9 1.6 0.002 18.5 0.0 6.0 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE38889.1 - 3.4e-12 46.1 0.2 0.00045 20.3 0.0 5.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE38889.1 - 2.4e-06 27.2 0.1 1 9.7 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeat SPX PF03105.14 EFE38889.1 - 0.00021 21.1 2.3 0.0081 15.9 0.0 2.8 3 0 0 3 3 3 1 SPX domain Ank_2 PF12796.2 EFE38890.1 - 2.1e-31 108.1 0.0 9.7e-12 45.0 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EFE38890.1 - 3.5e-29 99.1 5.1 6.5e-07 28.8 0.0 6.9 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 EFE38890.1 - 1.8e-24 85.6 2.8 5.8e-05 23.4 0.0 6.4 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE38890.1 - 5.5e-19 67.7 2.4 1.3e-06 28.4 0.0 5.2 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE38890.1 - 3e-18 64.0 0.9 0.0023 17.9 0.0 7.5 7 0 0 7 7 7 4 Ankyrin repeat Fungal_trans PF04082.13 EFE38892.1 - 4.3e-21 74.9 0.3 2.8e-19 68.9 0.0 2.6 2 0 0 2 2 2 2 Fungal specific transcription factor domain But2 PF09792.4 EFE38894.1 - 0.04 13.6 0.0 0.18 11.5 0.0 1.9 1 1 0 1 1 1 0 Ubiquitin 3 binding protein But2 C-terminal domain MFS_1 PF07690.11 EFE38895.1 - 3.4e-42 144.4 31.9 3.4e-42 144.4 22.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE38895.1 - 9.2e-16 57.4 4.9 9.2e-16 57.4 3.4 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 EFE38895.1 - 4.4e-06 25.1 1.0 4.4e-06 25.1 0.7 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF697 PF05128.7 EFE38895.1 - 2 7.8 4.6 7.6 6.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF697) Alpha-amylase PF00128.19 EFE38896.1 - 7.1e-24 84.7 1.3 8.5e-23 81.2 0.9 2.0 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DEAD PF00270.24 EFE38897.1 - 1.1e-25 90.0 0.3 1.6e-24 86.2 0.2 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE38897.1 - 3.7e-21 74.7 0.1 8.6e-21 73.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE38897.1 - 0.00034 20.5 0.0 0.00034 20.5 0.0 1.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 EFE38897.1 - 0.01 14.3 0.0 0.57 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) Ribonuc_L-PSP PF01042.16 EFE38898.1 - 3.1e-29 101.1 0.1 8.1e-29 99.8 0.0 1.6 1 1 0 1 1 1 1 Endoribonuclease L-PSP HLH PF00010.21 EFE38901.1 - 5.7e-08 32.3 0.1 2e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HNH_2 PF13391.1 EFE38902.1 - 9.5e-14 50.9 0.0 1.9e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease Maf PF02545.9 EFE38903.1 - 1.4e-42 145.0 0.0 1.8e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein CybS PF05328.7 EFE38904.1 - 2.1e-45 153.5 0.0 2.7e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 CybS Glyco_trans_1_4 PF13692.1 EFE38904.1 - 0.079 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 ADH_zinc_N PF00107.21 EFE38905.1 - 8.1e-22 77.1 0.0 1.4e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFE38905.1 - 5.8e-10 40.1 0.0 1e-09 39.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Peptidase_M16 PF00675.15 EFE38906.1 - 9.6e-56 187.6 0.1 3.3e-55 185.9 0.1 1.9 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EFE38906.1 - 5.2e-41 140.3 0.0 5.4e-40 137.0 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain MFS_1 PF07690.11 EFE38907.1 - 1.2e-28 99.8 56.2 8.6e-27 93.7 30.1 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Nitroreductase PF00881.19 EFE38908.1 - 1.5e-15 57.4 0.0 1.8e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Epimerase PF01370.16 EFE38909.1 - 6.4e-21 74.8 0.0 8.1e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFE38909.1 - 1.9e-09 36.6 0.0 2.4e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EFE38909.1 - 4.9e-07 29.9 0.0 7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EFE38909.1 - 4.6e-06 26.6 0.0 1.1e-05 25.4 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_4 PF07993.7 EFE38909.1 - 2.2e-05 23.4 0.1 0.075 11.9 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.12 EFE38909.1 - 0.00081 18.3 0.0 0.0015 17.4 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.5 EFE38909.1 - 0.0016 18.1 0.0 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.18 EFE38909.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Fibrillarin PF01269.12 EFE38910.1 - 1.1e-106 354.8 0.0 1.4e-106 354.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 EFE38910.1 - 4.9e-06 26.2 0.0 8e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 EFE38910.1 - 0.023 14.2 0.1 0.036 13.5 0.1 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 EFE38910.1 - 0.031 13.8 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF3455 PF11937.3 EFE38911.1 - 6.1e-42 143.5 0.0 7.5e-42 143.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) CASP_C PF08172.7 EFE38912.1 - 7.1e-88 293.8 1.2 7.1e-88 293.8 0.9 3.8 3 1 1 4 4 4 1 CASP C terminal Vps39_2 PF10367.4 EFE38913.1 - 2.2e-08 34.2 0.0 7.5e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.17 EFE38913.1 - 0.052 12.9 0.0 7 5.9 0.0 2.4 2 0 0 2 2 2 0 CNH domain PALP PF00291.20 EFE38914.1 - 1.1e-49 169.3 0.3 2.4e-49 168.2 0.2 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.23 EFE38914.1 - 9.4e-24 83.9 0.0 1.9e-23 82.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFE38914.1 - 1.4e-18 66.6 0.0 3.8e-18 65.2 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EFE38914.1 - 0.0025 17.5 0.1 0.0055 16.4 0.1 1.6 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.9 EFE38914.1 - 0.0038 16.0 0.0 5.4 5.6 0.0 3.1 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase UBA_4 PF14555.1 EFE38915.1 - 1.9e-11 43.2 0.0 3.7e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 EFE38915.1 - 4.2e-09 36.3 0.0 9.9e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 UBX domain DUF4207 PF13904.1 EFE38915.1 - 0.00019 20.9 7.4 0.00029 20.3 5.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) DDHD PF02862.12 EFE38915.1 - 0.059 13.1 0.9 0.1 12.4 0.6 1.5 1 0 0 1 1 1 0 DDHD domain Ycf1 PF05758.7 EFE38915.1 - 0.091 10.4 2.4 0.12 10.0 1.7 1.1 1 0 0 1 1 1 0 Ycf1 AAR2 PF05282.6 EFE38915.1 - 0.11 11.3 3.7 0.17 10.7 2.6 1.2 1 0 0 1 1 1 0 AAR2 protein DUF2201_N PF13203.1 EFE38917.1 - 4.2 6.4 6.7 4.6 6.3 4.6 1.0 1 0 0 1 1 1 0 Putative metallopeptidase domain FKBP_N PF01346.13 EFE38918.1 - 0.22 11.5 10.7 0.48 10.4 3.8 2.6 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Zn_clus PF00172.13 EFE38918.1 - 0.53 10.2 11.9 1.5 8.8 8.2 1.7 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Dioxygenase_C PF00775.16 EFE38919.1 - 1.9e-30 105.4 0.0 3.8e-30 104.4 0.0 1.5 1 1 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.9 EFE38919.1 - 4.6e-17 61.7 0.0 8.5e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.1 EFE38919.1 - 0.01 15.9 0.0 0.026 14.5 0.0 1.7 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Ribosomal_L22 PF00237.14 EFE38920.1 - 4.9e-34 116.4 0.0 7e-34 115.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e 2-Hacid_dh_C PF02826.14 EFE38921.1 - 7e-57 191.4 0.0 9.1e-57 191.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFE38921.1 - 3.6e-18 65.3 0.0 4.4e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFE38921.1 - 0.00067 19.5 0.1 0.0014 18.4 0.1 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 EFE38921.1 - 0.011 15.6 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ADH_zinc_N PF00107.21 EFE38923.1 - 8.5e-11 41.5 0.0 4.3e-10 39.2 0.0 2.1 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ApbA PF02558.11 EFE38923.1 - 0.031 13.7 0.0 0.048 13.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 EFE38923.1 - 0.04 13.2 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.16 EFE38923.1 - 0.091 12.5 0.1 0.091 12.5 0.1 1.9 2 0 0 2 2 2 0 ThiF family Saccharop_dh PF03435.13 EFE38923.1 - 0.098 11.6 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Ldh_1_N PF00056.18 EFE38923.1 - 0.12 12.1 0.1 0.12 12.1 0.1 1.6 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain ITAM_Cys-rich PF10538.4 EFE38923.1 - 0.13 11.8 0.1 0.24 10.9 0.1 1.4 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif adh_short PF00106.20 EFE38924.1 - 4.4e-19 69.0 0.1 1e-18 67.8 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE38924.1 - 1.4e-11 44.6 0.0 1.7e-11 44.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE38924.1 - 1.4e-05 24.8 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 EFE38924.1 - 0.084 11.9 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) OPT PF03169.10 EFE38925.1 - 2.7 6.3 9.8 3 6.1 6.8 1.0 1 0 0 1 1 1 0 OPT oligopeptide transporter protein PRA1 PF03208.14 EFE38925.1 - 9.4 5.5 8.7 14 4.9 6.0 1.3 1 1 0 1 1 1 0 PRA1 family protein Fungal_trans PF04082.13 EFE38926.1 - 1e-11 44.2 0.0 3.5e-11 42.4 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE38926.1 - 0.0088 15.9 4.0 0.017 15.0 2.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Neil1-DNA_bind PF09292.5 EFE38926.1 - 0.1 12.4 0.1 0.23 11.2 0.1 1.6 1 0 0 1 1 1 0 Endonuclease VIII-like 1, DNA bind BRF1 PF07741.8 EFE38927.1 - 2.6 8.3 6.9 2.7 8.2 4.8 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Peptidase_A21 PF03566.8 EFE38927.1 - 6.5 4.7 6.1 6.6 4.7 4.2 1.0 1 0 0 1 1 1 0 Peptidase family A21 Polysacc_deac_1 PF01522.16 EFE38928.1 - 4.1e-28 97.4 0.0 6.5e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 EFE38928.1 - 0.046 12.6 0.0 0.075 11.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Peptidase_M35 PF02102.10 EFE38929.1 - 1.4e-105 352.8 5.6 1.6e-105 352.7 3.9 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.1 EFE38929.1 - 4.3e-05 24.0 0.0 8.5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.1 EFE38929.1 - 0.0003 20.2 0.2 0.0018 17.7 0.1 1.9 1 1 0 1 1 1 1 Putative peptidase family Semialdhyde_dhC PF02774.13 EFE38930.1 - 2.7e-37 128.3 0.0 3.6e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 EFE38930.1 - 1.4e-14 54.4 0.0 6.6e-14 52.2 0.0 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Cation_ATPase_C PF00689.16 EFE38931.1 - 0.0036 16.8 0.1 0.0068 15.9 0.1 1.4 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus HLH PF00010.21 EFE38932.1 - 2.2e-07 30.4 0.1 5.7e-07 29.1 0.0 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Ser_hydrolase PF06821.8 EFE38933.1 - 0.015 14.8 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase AvrRpt-cleavage PF05627.6 EFE38933.1 - 0.021 13.8 5.7 1.2 8.1 0.1 4.3 5 0 0 5 5 5 0 Cleavage site for pathogenic type III effector avirulence factor Avr APH PF01636.18 EFE38934.1 - 1.1e-20 74.4 0.0 7.5e-20 71.6 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE38934.1 - 0.00013 20.7 0.0 0.0082 14.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.15 EFE38934.1 - 0.00016 20.9 0.0 0.00027 20.1 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.9 EFE38934.1 - 0.018 13.9 0.0 0.59 9.0 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase Pkinase PF00069.20 EFE38934.1 - 0.053 12.6 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain CENP-Q PF13094.1 EFE38935.1 - 1.4e-51 174.7 9.0 2.3e-51 174.0 6.2 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit BRE1 PF08647.6 EFE38935.1 - 0.014 15.3 7.5 0.048 13.6 5.2 2.0 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF904 PF06005.7 EFE38935.1 - 0.031 14.5 9.9 0.031 14.5 6.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF904) DUF3373 PF11853.3 EFE38935.1 - 0.053 12.0 2.7 0.071 11.6 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Cep57_CLD_2 PF14197.1 EFE38935.1 - 0.16 11.8 18.5 3.8 7.5 0.1 3.6 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 TMF_TATA_bd PF12325.3 EFE38935.1 - 0.22 11.2 10.0 0.17 11.6 5.3 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 EFE38935.1 - 0.22 11.0 6.3 0.29 10.7 4.4 1.4 1 0 0 1 1 1 0 IncA protein DUF4337 PF14235.1 EFE38935.1 - 0.44 10.3 3.9 1.1 9.0 2.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) TMF_DNA_bd PF12329.3 EFE38935.1 - 1.3 8.8 15.1 12 5.8 8.4 2.8 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.14 EFE38935.1 - 1.3 6.7 5.9 1.8 6.3 4.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.1 EFE38935.1 - 2.9 6.2 12.5 0.19 10.1 4.8 1.7 2 0 0 2 2 2 0 AAA domain Mnd1 PF03962.10 EFE38935.1 - 9.4 5.8 10.9 13 5.3 6.5 1.9 1 1 0 1 1 1 0 Mnd1 family Med3 PF11593.3 EFE38936.1 - 0.86 8.7 13.7 1.1 8.4 9.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SnoaL_2 PF12680.2 EFE38937.1 - 0.013 15.8 0.0 0.033 14.5 0.0 1.7 1 1 0 1 1 1 0 SnoaL-like domain WD40 PF00400.27 EFE38939.1 - 2.5e-18 65.1 14.6 8.1e-06 25.5 0.0 7.7 8 0 0 8 8 8 4 WD domain, G-beta repeat Phage-tail_3 PF13550.1 EFE38939.1 - 0.096 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative phage tail protein DUF3010 PF11215.3 EFE38939.1 - 0.21 11.5 0.0 0.47 10.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3010) FTA2 PF13095.1 EFE38940.1 - 1.7e-68 230.3 0.0 2.1e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Nucleoplasmin PF03066.10 EFE38941.1 - 0.013 14.9 1.3 0.02 14.3 0.9 1.2 1 0 0 1 1 1 0 Nucleoplasmin Shadoo PF14999.1 EFE38941.1 - 0.086 12.6 1.7 0.37 10.6 1.2 1.9 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective CENP-B_dimeris PF09026.5 EFE38941.1 - 1.8 8.8 9.0 3.3 8.0 6.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2464 PF10240.4 EFE38941.1 - 3.2 7.0 5.5 3.1 7.0 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2464) Sugar_tr PF00083.19 EFE38942.1 - 4.2e-78 262.9 21.3 5.2e-78 262.6 14.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE38942.1 - 1.5e-25 89.7 21.0 5.9e-24 84.4 13.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily GCN5L1 PF06320.8 EFE38943.1 - 2.7e-10 40.1 1.9 3.3e-10 39.8 1.3 1.2 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) PilJ PF13675.1 EFE38943.1 - 0.013 15.7 2.1 0.02 15.2 1.5 1.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF3552 PF12072.3 EFE38943.1 - 0.016 14.4 2.7 0.018 14.2 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) CagE_TrbE_VirB PF03135.9 EFE38943.1 - 0.028 14.1 0.5 0.03 14.0 0.3 1.1 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system Nsp1_C PF05064.8 EFE38943.1 - 0.06 12.9 3.7 0.068 12.8 2.0 1.5 1 1 0 1 1 1 0 Nsp1-like C-terminal region Laminin_II PF06009.7 EFE38943.1 - 0.064 13.0 2.3 0.078 12.7 1.4 1.3 1 1 0 1 1 1 0 Laminin Domain II zf-C4H2 PF10146.4 EFE38943.1 - 0.11 12.4 0.4 0.13 12.2 0.3 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DivIC PF04977.10 EFE38943.1 - 0.21 11.1 2.6 0.37 10.2 1.8 1.4 1 0 0 1 1 1 0 Septum formation initiator CHASE3 PF05227.8 EFE38943.1 - 0.22 11.1 6.1 2.2 7.9 3.3 2.3 1 1 1 2 2 2 0 CHASE3 domain APG6 PF04111.7 EFE38943.1 - 0.32 10.0 3.5 0.35 9.8 2.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF848 PF05852.6 EFE38943.1 - 0.49 10.2 5.2 0.61 9.9 3.4 1.3 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Syntaxin-6_N PF09177.6 EFE38943.1 - 0.68 10.3 5.1 5.3 7.5 2.6 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4164 PF13747.1 EFE38943.1 - 3.2 7.9 8.1 1.8 8.7 3.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DNA_mis_repair PF01119.14 EFE38944.1 - 6.2e-21 74.0 0.0 3.5e-19 68.4 0.0 2.6 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.6 EFE38944.1 - 1.8e-18 66.5 1.6 4e-15 55.6 0.9 3.0 3 0 0 3 3 3 2 MutL C terminal dimerisation domain HATPase_c_3 PF13589.1 EFE38944.1 - 4e-14 52.4 0.0 1.1e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EFE38944.1 - 1.6e-12 47.0 0.0 3.8e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Serinc PF03348.10 EFE38945.1 - 1.8e-165 550.8 8.0 2.1e-165 550.6 5.6 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) FA_desaturase PF00487.19 EFE38945.1 - 0.013 14.9 12.9 0.2 11.0 4.2 2.9 2 1 1 3 3 3 0 Fatty acid desaturase ATG27 PF09451.5 EFE38945.1 - 5.7 6.0 5.7 0.74 8.9 0.1 2.2 2 1 0 2 2 2 0 Autophagy-related protein 27 Nodulin-like PF06813.8 EFE38946.1 - 5.3e-17 61.9 10.1 3.6e-14 52.6 7.0 2.2 1 1 0 1 1 1 1 Nodulin-like MFS_1 PF07690.11 EFE38946.1 - 1e-06 27.7 19.0 0.00017 20.4 9.0 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily Claudin_2 PF13903.1 EFE38947.1 - 0.032 13.9 4.9 0.053 13.2 3.4 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction MFS_1 PF07690.11 EFE38947.1 - 0.065 11.9 10.3 0.089 11.4 3.8 2.1 1 1 0 2 2 2 0 Major Facilitator Superfamily BTP PF05232.7 EFE38947.1 - 0.11 12.1 1.8 0.31 10.8 1.3 1.8 1 1 0 1 1 1 0 Bacterial Transmembrane Pair family DUF3816 PF12822.2 EFE38947.1 - 0.13 12.1 5.5 0.18 11.6 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) Pkinase PF00069.20 EFE38948.1 - 3.8e-11 42.6 0.1 3.6e-10 39.4 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE38948.1 - 6.6e-10 38.4 0.0 4.3e-09 35.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Mob1_phocein PF03637.12 EFE38949.1 - 1.6e-23 83.2 0.8 2e-23 82.9 0.0 1.4 2 0 0 2 2 2 1 Mob1/phocein family cobW PF02492.14 EFE38950.1 - 5.6e-27 94.3 0.1 8.1e-27 93.7 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 EFE38950.1 - 5e-07 29.3 0.0 9.3e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain Auxin_BP PF02041.11 EFE38950.1 - 0.024 14.0 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 Auxin binding protein HAUS6_N PF14661.1 EFE38951.1 - 2.3e-64 217.1 0.3 5.4e-64 215.9 0.0 1.7 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus HD_3 PF13023.1 EFE38952.1 - 4e-47 160.0 0.1 4.9e-47 159.7 0.1 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 EFE38952.1 - 0.0022 18.0 0.0 0.0041 17.1 0.0 1.5 1 0 0 1 1 1 1 HD domain HATPase_c_4 PF13749.1 EFE38952.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 ATP-dependent DNA helicase recG C-terminal Rad4 PF03835.10 EFE38953.1 - 1.2e-29 102.5 0.1 1.2e-29 102.5 0.1 2.4 3 0 0 3 3 3 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 EFE38953.1 - 1.8e-28 98.0 0.1 3.3e-28 97.2 0.1 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.4 EFE38953.1 - 2.4e-17 62.9 0.0 6.9e-17 61.5 0.0 1.9 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.4 EFE38953.1 - 3.3e-17 61.7 1.7 1.6e-16 59.5 0.1 2.4 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.14 EFE38953.1 - 0.00034 20.7 0.0 0.002 18.2 0.0 2.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily Sigma70_ner PF04546.8 EFE38953.1 - 8.5 5.9 12.0 0.69 9.4 3.4 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region HIT PF01230.18 EFE38954.1 - 7.4e-23 80.9 0.3 1.3e-22 80.1 0.0 1.5 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.3 EFE38954.1 - 1.9e-06 28.0 0.0 3.9e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 EFE38954.1 - 0.0079 15.8 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Methyltransf_11 PF08241.7 EFE38955.1 - 2.8e-23 82.2 0.0 4.6e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38955.1 - 1.4e-15 57.1 0.0 1.8e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38955.1 - 2.3e-15 56.8 0.0 3.9e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38955.1 - 2e-14 54.1 0.0 3.6e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE38955.1 - 1.1e-12 48.2 0.0 4.7e-12 46.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38955.1 - 6.1e-12 45.5 0.0 8.9e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE38955.1 - 4e-09 35.9 0.0 3e-08 33.0 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFE38955.1 - 6.1e-09 35.9 0.0 1.3e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE38955.1 - 1.4e-05 24.5 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EFE38955.1 - 0.00062 18.9 0.0 0.00092 18.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 EFE38955.1 - 0.0021 17.1 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DREV PF05219.7 EFE38955.1 - 0.0021 16.9 0.0 0.0033 16.3 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase MetW PF07021.7 EFE38955.1 - 0.0026 17.1 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.9 EFE38955.1 - 0.0054 15.9 0.0 0.0079 15.3 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_24 PF13578.1 EFE38955.1 - 0.0093 16.7 0.0 0.024 15.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EFE38955.1 - 0.013 14.2 0.0 0.018 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_32 PF13679.1 EFE38955.1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.10 EFE38955.1 - 0.045 13.3 0.0 0.12 12.0 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase tRNA_U5-meth_tr PF05958.6 EFE38955.1 - 0.15 10.6 0.0 0.24 10.0 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase CoA_binding_2 PF13380.1 EFE38956.1 - 0.077 13.1 0.0 0.085 13.0 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain CoA_binding_2 PF13380.1 EFE38957.1 - 2.1e-10 40.7 0.0 3.5e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 CoA binding domain DUF2036 PF09724.4 EFE38959.1 - 6.6e-21 74.7 0.0 1.7e-20 73.4 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) Med3 PF11593.3 EFE38959.1 - 3.9 6.6 19.9 7 5.7 13.8 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Anp1 PF03452.9 EFE38960.1 - 2.9e-116 387.3 2.2 1.3e-115 385.2 0.0 2.3 2 0 0 2 2 2 1 Anp1 DUF1675 PF07897.6 EFE38960.1 - 0.45 10.3 27.1 0.044 13.6 15.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1675) tRNA_bind PF01588.15 EFE38961.1 - 5.3e-21 74.2 0.0 2e-19 69.2 0.0 2.5 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.1 EFE38961.1 - 2.4e-10 40.7 0.1 5.3e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFE38961.1 - 0.025 14.4 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Asp PF00026.18 EFE38962.1 - 9e-63 212.4 0.0 1e-62 212.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 EFE38962.1 - 1.6e-08 34.8 0.3 0.00018 21.9 0.1 2.5 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.1 EFE38962.1 - 0.00033 20.4 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.1 EFE38962.1 - 0.13 11.8 0.1 1.8 8.0 0.1 2.2 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal RVP PF00077.15 EFE38962.1 - 0.14 12.1 0.2 8.4 6.3 0.0 2.3 2 0 0 2 2 2 0 Retroviral aspartyl protease FAD_binding_4 PF01565.18 EFE38962.1 - 0.33 10.4 1.6 2 7.9 0.0 2.9 4 0 0 4 4 4 0 FAD binding domain ParA PF10609.4 EFE38963.1 - 2.5e-35 120.2 0.0 4.5e-35 119.3 0.0 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EFE38963.1 - 3.4e-17 62.4 0.0 4.8e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EFE38963.1 - 6.5e-07 29.4 0.0 2.9e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.10 EFE38963.1 - 1.5e-05 24.1 1.6 0.00056 19.0 0.3 2.6 1 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.6 EFE38963.1 - 0.0002 20.5 0.0 0.00037 19.6 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.1 EFE38963.1 - 0.0036 16.9 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFE38963.1 - 0.012 14.8 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 EFE38963.1 - 0.017 14.5 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 EFE38963.1 - 0.057 12.8 0.0 0.13 11.6 0.0 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_17 PF13207.1 EFE38963.1 - 0.072 13.9 0.0 0.11 13.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFE38963.1 - 0.084 13.0 0.0 0.21 11.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain Zn_Tnp_IS1595 PF12760.2 EFE38963.1 - 0.1 12.4 0.1 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain AAA_30 PF13604.1 EFE38963.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFE38963.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase PEMT PF04191.8 EFE38964.1 - 6.6e-59 196.5 10.4 3.8e-36 123.4 0.4 3.3 3 0 0 3 3 3 2 Phospholipid methyltransferase FGGY_C PF02782.11 EFE38965.1 - 2.9e-50 170.6 0.1 5.3e-50 169.8 0.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFE38965.1 - 6.3e-24 84.6 0.0 2.6e-21 76.0 0.0 2.3 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain F-box-like_2 PF13013.1 EFE38967.1 - 2.3e-06 27.2 0.6 4.9e-06 26.2 0.4 1.5 1 0 0 1 1 1 1 F-box-like domain F-box PF00646.28 EFE38967.1 - 0.0037 16.8 2.4 0.0076 15.8 1.6 1.6 1 0 0 1 1 1 1 F-box domain PPP4R2 PF09184.6 EFE38967.1 - 5.5 6.4 13.3 7.9 5.9 9.2 1.2 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.9 EFE38967.1 - 5.8 4.8 7.3 8.1 4.3 5.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Y_phosphatase PF00102.22 EFE38968.1 - 1.4e-65 220.9 0.1 2.1e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 EFE38968.1 - 3e-10 40.4 0.0 1.7e-09 38.0 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.15 EFE38968.1 - 0.013 15.0 0.4 0.031 13.8 0.3 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 EFE38968.1 - 0.14 12.3 0.1 0.41 10.8 0.1 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family ATP-synt_E PF05680.7 EFE38969.1 - 9.3 6.2 11.1 12 5.8 0.4 2.6 2 0 0 2 2 2 0 ATP synthase E chain Pkinase PF00069.20 EFE38971.1 - 1.2e-11 44.2 0.0 7.7e-10 38.3 0.0 2.9 1 1 0 1 1 1 1 Protein kinase domain tRNA-synt_1g PF09334.6 EFE38973.1 - 4.7e-120 400.8 0.1 2.4e-119 398.5 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (M) Choline_transpo PF04515.7 EFE38975.1 - 1.8e-102 342.5 20.1 1.8e-102 342.5 13.9 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter Amidohydro_1 PF01979.15 EFE38977.1 - 9.2e-38 130.7 0.0 1.1e-37 130.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 EFE38977.1 - 5.3e-07 29.1 0.0 0.00015 21.1 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.17 EFE38977.1 - 4.8e-05 22.4 0.0 7.9e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_4 PF13147.1 EFE38977.1 - 0.0011 19.0 0.0 0.84 9.6 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 EFE38977.1 - 0.0035 17.1 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 Amidohydrolase Toxin_29 PF08116.6 EFE38977.1 - 0.029 14.1 0.3 0.086 12.6 0.2 1.8 1 0 0 1 1 1 0 PhTx neurotoxin family tRNA_int_endo_N PF02778.9 EFE38977.1 - 0.18 11.3 0.0 0.38 10.3 0.0 1.5 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain Sulfatase PF00884.18 EFE38978.1 - 8.4e-59 199.2 0.1 1.2e-58 198.7 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.3 EFE38978.1 - 8.2e-21 73.5 0.1 4.4e-20 71.2 0.0 2.2 1 1 1 2 2 2 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.17 EFE38978.1 - 1.1e-08 34.8 2.9 1.3e-06 28.0 2.0 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.1 EFE38978.1 - 0.019 15.2 0.0 0.05 13.8 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase Peptidase_C16 PF01831.12 EFE38978.1 - 0.025 14.1 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase C16 family Tox-HDC PF15656.1 EFE38978.1 - 0.061 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Toxin with a H, D/N and C signature DUF229 PF02995.12 EFE38978.1 - 0.14 10.5 0.0 0.17 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Fungal_trans PF04082.13 EFE38979.1 - 4.4e-16 58.5 0.0 7e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE38979.1 - 2.4e-08 33.7 9.3 4.1e-08 33.0 6.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EFE38980.1 - 2.9e-42 144.6 55.0 2.3e-41 141.6 38.1 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3377 PF11857.3 EFE38980.1 - 0.065 12.8 0.1 0.36 10.4 0.1 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) WTF PF03303.8 EFE38980.1 - 0.11 11.9 6.3 0.25 10.7 4.3 1.7 1 0 0 1 1 1 0 WTF protein Rota_NS53 PF00981.12 EFE38981.1 - 0.1 11.2 0.5 0.15 10.6 0.3 1.2 1 0 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) PHD PF00628.24 EFE38981.1 - 0.25 11.0 7.6 0.4 10.4 2.2 2.3 2 0 0 2 2 2 0 PHD-finger zf-Sec23_Sec24 PF04810.10 EFE38981.1 - 1.2 8.7 5.2 1.5 8.4 0.1 3.0 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger Sterol_MT_C PF08498.5 EFE38982.1 - 5.3e-28 96.7 0.1 8e-28 96.1 0.0 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 EFE38982.1 - 7.1e-18 64.8 0.0 1.3e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE38982.1 - 9.3e-17 61.0 0.0 1.4e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE38982.1 - 2.4e-14 53.3 0.0 3.9e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38982.1 - 1.2e-12 48.0 0.0 2.2e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE38982.1 - 4.3e-11 43.3 0.0 1e-10 42.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFE38982.1 - 4.4e-11 42.3 0.0 6.6e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 EFE38982.1 - 6e-11 42.6 0.0 1.4e-10 41.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE38982.1 - 3.2e-09 36.2 0.0 5.1e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFE38982.1 - 8.3e-09 35.4 0.0 2e-08 34.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 EFE38982.1 - 7.2e-05 22.3 0.0 0.0001 21.8 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 EFE38982.1 - 0.00011 21.5 0.0 0.00055 19.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain PCMT PF01135.14 EFE38982.1 - 0.00098 18.7 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.8 EFE38982.1 - 0.0017 17.5 0.0 0.0029 16.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.1 EFE38982.1 - 0.0075 15.9 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFE38982.1 - 0.014 14.4 0.0 0.042 12.9 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase RrnaAD PF00398.15 EFE38982.1 - 0.018 14.0 0.0 0.029 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_24 PF13578.1 EFE38982.1 - 0.03 15.1 0.0 0.1 13.4 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_2 PF00891.13 EFE38982.1 - 0.098 11.8 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase UPF0020 PF01170.13 EFE38982.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 RRM_5 PF13893.1 EFE38983.1 - 7.8e-12 44.8 0.0 2.1e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE38983.1 - 4e-10 39.1 0.0 7e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE38983.1 - 3e-06 27.1 0.0 5.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE38983.1 - 0.011 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DnaJ PF00226.26 EFE38984.1 - 4.2e-20 71.2 0.3 1.9e-19 69.1 0.2 2.3 1 0 0 1 1 1 1 DnaJ domain Glyco_hydro_76 PF03663.9 EFE38985.1 - 7.6e-155 515.8 5.5 9.5e-155 515.5 3.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 EFE38985.1 - 0.0025 16.9 8.0 0.01 14.9 0.0 3.1 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 PFK PF00365.15 EFE38986.1 - 8.5e-170 563.0 0.1 4.2e-123 409.8 0.2 2.1 2 0 0 2 2 2 2 Phosphofructokinase NAD_kinase PF01513.16 EFE38986.1 - 0.12 11.1 0.2 0.55 8.9 0.1 1.9 2 0 0 2 2 2 0 ATP-NAD kinase Med17 PF10156.4 EFE38987.1 - 1.3e-113 379.7 1.2 1.6e-113 379.5 0.8 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex ISN1 PF06437.6 EFE38988.1 - 1e-175 584.3 0.0 1.3e-175 584.0 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase eIF-5a PF01287.15 EFE38988.1 - 0.069 13.1 0.0 0.2 11.6 0.0 1.9 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold RasGEF_N_2 PF14663.1 EFE38988.1 - 0.076 12.9 0.2 0.6 10.0 0.1 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HNH_2 PF13391.1 EFE38989.1 - 5.5e-10 38.8 0.2 1.4e-09 37.5 0.1 1.7 1 0 0 1 1 1 1 HNH endonuclease p450 PF00067.17 EFE38990.1 - 2.8e-57 194.2 0.0 3.8e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans_2 PF11951.3 EFE38992.1 - 2e-17 62.9 0.2 3.1e-17 62.2 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_33 PF10017.4 EFE38993.1 - 3.1e-21 75.5 0.0 5.8e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_32 PF13679.1 EFE38993.1 - 0.031 13.9 0.1 0.17 11.5 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 EFE38993.1 - 0.032 14.5 0.0 0.057 13.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain DAO PF01266.19 EFE38994.1 - 2.1e-40 138.7 0.0 2.9e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFE38994.1 - 0.00066 19.4 0.0 0.073 12.8 0.0 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFE38994.1 - 0.00069 19.5 0.0 0.0018 18.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Saccharop_dh PF03435.13 EFE38994.1 - 0.00076 18.5 0.0 0.0017 17.4 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase Pyr_redox_2 PF07992.9 EFE38994.1 - 0.00086 19.2 0.0 0.076 12.8 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 EFE38994.1 - 0.017 15.1 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain K_oxygenase PF13434.1 EFE38994.1 - 0.017 14.0 0.0 0.035 13.0 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Abhydrolase_6 PF12697.2 EFE38994.1 - 0.074 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family cNMP_binding PF00027.24 EFE38995.1 - 9.7e-42 140.7 0.1 1.8e-22 78.9 0.0 4.5 4 0 0 4 4 4 3 Cyclic nucleotide-binding domain Patatin PF01734.17 EFE38995.1 - 8.5e-18 65.0 10.6 2.5e-17 63.4 4.9 3.0 2 1 0 2 2 2 1 Patatin-like phospholipase DUF2296 PF10058.4 EFE38996.1 - 9.2e-19 66.9 0.1 1.4e-18 66.3 0.1 1.3 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) Fusion_gly_K PF01621.12 EFE38996.1 - 0.048 12.6 0.9 0.068 12.2 0.6 1.1 1 0 0 1 1 1 0 Cell fusion glycoprotein K DUF4463 PF14703.1 EFE38996.1 - 0.073 13.6 2.2 0.25 11.8 1.4 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4463) GRIP PF01465.15 EFE38997.1 - 2.4e-15 55.7 0.2 4.9e-15 54.7 0.2 1.5 1 0 0 1 1 1 1 GRIP domain TPR_MLP1_2 PF07926.7 EFE38997.1 - 2.1e-06 27.5 121.3 0.2 11.4 10.0 10.2 2 1 3 6 6 5 3 TPR/MLP1/MLP2-like protein IncA PF04156.9 EFE38997.1 - 3e-05 23.7 145.1 0.016 14.8 11.1 9.1 3 2 5 8 8 7 5 IncA protein CENP-F_leu_zip PF10473.4 EFE38997.1 - 4.6e-05 23.3 146.5 0.0096 15.7 15.5 9.3 3 2 6 9 9 9 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 EFE38997.1 - 9.8e-05 21.6 57.8 0.025 13.7 5.6 6.8 4 2 3 7 7 7 5 Reovirus sigma C capsid protein Tropomyosin_1 PF12718.2 EFE38997.1 - 0.00013 21.8 145.8 0.052 13.4 23.4 8.5 3 2 5 8 8 8 5 Tropomyosin like Myosin_tail_1 PF01576.14 EFE38997.1 - 0.00037 18.3 139.0 0.0092 13.7 14.7 6.1 3 1 1 5 5 5 4 Myosin tail Filament PF00038.16 EFE38997.1 - 0.00059 19.3 123.6 0.033 13.6 13.2 7.1 3 2 3 6 6 6 3 Intermediate filament protein GAS PF13851.1 EFE38997.1 - 0.00061 19.0 126.8 0.002 17.3 7.6 8.6 3 2 4 8 8 8 5 Growth-arrest specific micro-tubule binding AAA_13 PF13166.1 EFE38997.1 - 0.00063 18.3 101.4 0.0035 15.8 10.3 6.1 3 1 2 6 6 6 4 AAA domain TMF_DNA_bd PF12329.3 EFE38997.1 - 0.00067 19.4 12.0 0.00067 19.4 8.3 13.8 6 4 7 14 14 13 6 TATA element modulatory factor 1 DNA binding ATG16 PF08614.6 EFE38997.1 - 0.0033 17.2 7.6 0.0033 17.2 5.2 10.0 2 2 5 8 8 7 2 Autophagy protein 16 (ATG16) Spc7 PF08317.6 EFE38997.1 - 0.0042 15.8 122.4 0.013 14.1 12.8 7.7 3 2 3 7 7 7 3 Spc7 kinetochore protein Bap31 PF05529.7 EFE38997.1 - 0.031 13.7 0.1 0.031 13.7 0.1 10.5 5 4 4 9 9 5 0 B-cell receptor-associated protein 31-like DUF869 PF05911.6 EFE38997.1 - 0.044 12.0 124.4 0.12 10.6 0.6 5.9 2 1 3 5 5 5 0 Plant protein of unknown function (DUF869) DUF3584 PF12128.3 EFE38997.1 - 0.084 10.2 117.6 0.0043 14.4 11.1 4.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3584) TBPIP PF07106.8 EFE38997.1 - 0.34 10.4 111.4 0.2 11.2 8.1 9.9 3 2 8 11 11 11 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Phage_GP20 PF06810.6 EFE38997.1 - 2.5 7.5 111.5 0.057 12.8 1.3 9.9 5 3 3 9 9 9 0 Phage minor structural protein GP20 APG6 PF04111.7 EFE38997.1 - 3.1 6.7 128.8 0.25 10.3 4.8 7.6 3 2 5 8 8 8 0 Autophagy protein Apg6 DUF4140 PF13600.1 EFE38997.1 - 3.8 8.0 0.0 3.8 8.0 0.0 14.5 5 2 6 12 12 10 0 N-terminal domain of unknown function (DUF4140) DUF641 PF04859.7 EFE38997.1 - 4 7.1 95.1 0.077 12.7 6.7 11.0 5 3 6 11 11 11 0 Plant protein of unknown function (DUF641) Laminin_II PF06009.7 EFE38997.1 - 6.5 6.5 90.2 0.43 10.3 2.5 9.0 4 3 4 8 8 8 0 Laminin Domain II Acetyltransf_1 PF00583.19 EFE38998.1 - 3.4e-16 59.0 0.0 5e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE38998.1 - 8.7e-08 32.2 0.0 1.9e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE38998.1 - 9.1e-08 31.7 0.0 1.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 EFE38998.1 - 9.8e-08 32.2 0.0 1.2e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE38998.1 - 4.4e-05 23.5 0.0 8e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EFE38998.1 - 0.011 15.6 0.0 0.04 13.8 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFE38998.1 - 0.019 14.8 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase JAB PF01398.16 EFE39000.1 - 6.5e-36 122.5 0.1 1.5e-35 121.3 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 EFE39000.1 - 2.6e-27 95.1 0.4 5.8e-27 94.0 0.3 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 EFE39000.1 - 4.2e-09 35.9 0.0 1.2e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UCR_14kD PF02271.11 EFE39000.1 - 0.035 13.8 0.1 0.061 13.0 0.1 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex 14kD subunit Hist_deacetyl PF00850.14 EFE39001.1 - 1.3e-78 264.4 0.0 2.2e-78 263.7 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Ribosomal_L14 PF00238.14 EFE39002.1 - 7e-32 109.7 0.0 7.6e-32 109.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Metallophos PF00149.23 EFE39003.1 - 1.1e-10 41.2 1.2 2.5e-10 40.0 0.8 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SH3_1 PF00018.23 EFE39003.1 - 1.5e-09 37.0 0.0 3.6e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.24 EFE39003.1 - 5.7e-09 36.1 0.0 1.9e-08 34.4 0.0 2.0 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.12 EFE39003.1 - 2.4e-08 33.7 0.1 5e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.1 EFE39003.1 - 3.7e-07 29.6 0.2 8.8e-07 28.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.1 EFE39003.1 - 2.7e-05 24.3 2.1 3.8e-05 23.9 0.0 2.5 3 0 0 3 3 3 1 Pleckstrin homology domain SH3_2 PF07653.12 EFE39003.1 - 0.00023 20.5 0.1 0.00048 19.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.25 EFE39003.1 - 0.0029 17.7 0.1 0.0054 16.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Gastrin PF00918.12 EFE39003.1 - 0.019 15.7 1.9 0.042 14.6 0.2 2.5 2 0 0 2 2 2 0 Gastrin/cholecystokinin family eIF-4B PF06273.6 EFE39004.1 - 0.13 10.9 12.1 0.14 10.8 8.4 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B zf-MIZ PF02891.15 EFE39005.1 - 8.8e-11 41.1 0.2 2e-10 39.9 0.1 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PsbJ PF01788.12 EFE39005.1 - 0.16 11.5 0.7 0.33 10.5 0.5 1.5 1 0 0 1 1 1 0 PsbJ Nsp1_C PF05064.8 EFE39007.1 - 8.6e-43 144.7 3.9 8.6e-43 144.7 2.7 1.7 2 0 0 2 2 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.1 EFE39007.1 - 2.2e-09 37.5 174.9 8.1e-07 29.2 27.9 5.8 1 1 5 6 6 4 4 Nucleoporin FG repeat region DUF4407 PF14362.1 EFE39007.1 - 0.098 11.6 7.2 0.17 10.8 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LOH1CR12 PF10158.4 EFE39007.1 - 0.22 11.2 0.8 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Tumour suppressor protein Baculo_PEP_C PF04513.7 EFE39007.1 - 0.25 11.1 5.9 0.39 10.5 3.2 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ArsC PF03960.10 EFE39007.1 - 0.35 10.9 5.6 12 5.9 0.1 3.1 1 1 2 3 3 3 0 ArsC family DUF4200 PF13863.1 EFE39007.1 - 0.67 9.9 12.1 0.069 13.1 4.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Tropomyosin_1 PF12718.2 EFE39007.1 - 0.71 9.7 12.3 0.073 12.9 4.1 2.1 1 1 1 2 2 2 0 Tropomyosin like FlaC_arch PF05377.6 EFE39007.1 - 0.77 9.7 3.7 7.3 6.5 0.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) AAA_13 PF13166.1 EFE39007.1 - 0.97 7.8 10.2 1 7.7 2.3 1.9 1 1 1 2 2 2 0 AAA domain Spc7 PF08317.6 EFE39007.1 - 1.1 7.9 13.5 0.35 9.4 0.7 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Syntaxin PF00804.20 EFE39007.1 - 1.5 9.0 7.0 31 4.7 4.8 2.4 1 1 0 1 1 1 0 Syntaxin ParB PF08775.5 EFE39007.1 - 1.9 8.8 4.8 0.6 10.4 0.1 2.2 2 1 0 2 2 2 0 ParB family APG6 PF04111.7 EFE39007.1 - 2.3 7.1 10.7 0.37 9.7 4.3 1.6 1 1 1 2 2 2 0 Autophagy protein Apg6 MscS_porin PF12795.2 EFE39007.1 - 5.3 6.2 18.3 0.4 9.9 4.6 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain CENP-Q PF13094.1 EFE39007.1 - 8.1 6.4 11.5 31 4.5 7.6 2.1 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit V_ATPase_I PF01496.14 EFE39007.1 - 9.4 3.9 6.3 5.8 4.6 2.7 1.5 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family V-SNARE PF05008.10 EFE39007.1 - 9.7 6.4 9.4 1.3 9.2 0.5 3.1 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus 14-3-3 PF00244.15 EFE39008.1 - 1.9e-114 380.6 7.3 2.3e-114 380.3 5.0 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF3461 PF11944.3 EFE39008.1 - 0.074 12.9 2.2 0.51 10.1 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3461) DUF2205 PF10224.4 EFE39009.1 - 5e-25 86.8 0.2 9.5e-25 85.9 0.2 1.4 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) Macoilin PF09726.4 EFE39009.1 - 0.0015 16.9 3.8 0.0017 16.7 2.6 1.0 1 0 0 1 1 1 1 Transmembrane protein DUF4201 PF13870.1 EFE39009.1 - 0.0078 15.6 0.4 0.011 15.1 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) CASP_C PF08172.7 EFE39009.1 - 0.019 14.0 0.9 0.019 14.0 0.7 2.0 2 0 0 2 2 2 0 CASP C terminal DUF972 PF06156.8 EFE39009.1 - 0.023 15.0 0.6 0.038 14.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Prefoldin PF02996.12 EFE39009.1 - 0.033 13.8 0.7 0.055 13.1 0.5 1.4 1 0 0 1 1 1 0 Prefoldin subunit DivIC PF04977.10 EFE39009.1 - 0.036 13.5 0.4 0.059 12.8 0.3 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4140 PF13600.1 EFE39009.1 - 0.06 13.7 0.3 0.06 13.7 0.2 1.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4208 PF13907.1 EFE39009.1 - 0.095 12.9 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) HALZ PF02183.13 EFE39009.1 - 0.26 11.0 1.6 2.4 7.9 0.0 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper Aminotran_1_2 PF00155.16 EFE39011.1 - 1e-74 251.7 0.0 1.2e-74 251.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4246 PF14033.1 EFE39012.1 - 3.6e-187 622.9 0.5 4.4e-187 622.6 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.1 EFE39012.1 - 2.7e-05 24.3 0.0 6.3e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase DUF4066 PF13278.1 EFE39013.1 - 1.7e-31 108.6 0.0 2.2e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 EFE39013.1 - 2e-16 59.7 0.0 2.5e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.23 EFE39013.1 - 0.0064 15.9 0.0 0.0092 15.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.9 EFE39013.1 - 0.041 13.4 0.0 0.057 13.0 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain IMS PF00817.15 EFE39014.1 - 2.9e-40 137.4 0.0 6.8e-40 136.2 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EFE39014.1 - 3.3e-21 75.5 0.0 1e-20 73.9 0.0 1.9 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF4414 PF14377.1 EFE39014.1 - 2e-12 46.9 7.1 9.4e-07 28.7 0.3 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF4414) BRCT PF00533.21 EFE39014.1 - 1.6e-07 31.3 0.0 4.6e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain IMS_HHH PF11798.3 EFE39014.1 - 0.00046 20.0 0.1 0.0035 17.2 0.0 2.6 2 0 0 2 2 2 1 IMS family HHH motif PTCB-BRCT PF12738.2 EFE39014.1 - 0.0025 17.6 0.0 0.0053 16.5 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain F420_ligase PF01996.11 EFE39014.1 - 0.044 12.8 0.0 0.097 11.7 0.0 1.6 1 0 0 1 1 1 0 F420-0:Gamma-glutamyl ligase HHH_5 PF14520.1 EFE39014.1 - 0.052 13.7 0.0 0.21 11.7 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain DUF1805 PF08827.6 EFE39014.1 - 0.056 13.2 0.0 0.29 10.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1805) FKBP_C PF00254.23 EFE39015.1 - 4.3e-30 103.5 0.0 1.8e-29 101.5 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase Daxx PF03344.10 EFE39015.1 - 0.34 9.3 46.8 0.22 9.9 14.2 2.1 2 0 0 2 2 2 0 Daxx Family Pkinase PF00069.20 EFE39016.1 - 1.5e-47 161.9 0.2 1.3e-27 96.6 0.1 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39016.1 - 3e-20 72.4 0.0 2.8e-13 49.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 EFE39016.1 - 0.072 12.8 0.1 0.072 12.8 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF3591 PF12157.3 EFE39017.1 - 2.6e-198 659.0 0.2 3.5e-198 658.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC PF00098.18 EFE39017.1 - 0.015 15.1 0.9 0.028 14.3 0.6 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.1 EFE39017.1 - 0.075 12.7 1.2 0.19 11.4 0.8 1.7 1 0 0 1 1 1 0 Zinc knuckle Methyltransf_15 PF09445.5 EFE39018.1 - 1.4e-40 138.5 0.0 2.1e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 EFE39018.1 - 2.5e-09 37.1 0.0 3.7e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 EFE39018.1 - 1.6e-08 34.3 0.0 2.1e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.11 EFE39018.1 - 2.8e-08 33.6 0.0 3.6e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.10 EFE39018.1 - 4.3e-08 32.7 0.0 5.8e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.2 EFE39018.1 - 6.7e-06 26.6 0.0 8.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE39018.1 - 0.00012 21.7 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Sigma54_activ_2 PF14532.1 EFE39018.1 - 0.0025 17.8 0.0 0.0046 17.0 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain MTS PF05175.9 EFE39018.1 - 0.013 14.9 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_5 PF01795.14 EFE39018.1 - 0.028 13.7 0.0 0.039 13.2 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family Methyltransf_3 PF01596.12 EFE39018.1 - 0.031 13.3 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase GRASP55_65 PF04495.9 EFE39019.1 - 6e-40 136.4 0.0 3.3e-39 134.0 0.0 1.9 1 1 1 2 2 2 1 GRASP55/65 PDZ-like domain ApoO PF09769.4 EFE39020.1 - 2.7e-49 166.9 0.6 7.2e-49 165.5 0.1 1.8 2 0 0 2 2 2 1 Apolipoprotein O Peptidase_M3 PF01432.15 EFE39021.1 - 1.6e-119 399.9 0.0 2.3e-119 399.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 O-FucT PF10250.4 EFE39021.1 - 0.085 11.9 0.1 0.18 10.8 0.0 1.5 2 0 0 2 2 2 0 GDP-fucose protein O-fucosyltransferase DUF1886 PF09171.5 EFE39021.1 - 0.1 11.6 0.1 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1886) Methyltransf_23 PF13489.1 EFE39022.1 - 1.7e-25 89.6 0.0 2.5e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE39022.1 - 2.4e-10 40.2 0.0 1.8e-09 37.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE39022.1 - 8.5e-09 35.9 0.0 1.8e-07 31.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE39022.1 - 3.5e-07 30.5 0.0 1e-06 29.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE39022.1 - 9.8e-07 29.1 0.0 1.9e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFE39022.1 - 0.00021 20.4 0.5 0.00071 18.6 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFE39022.1 - 0.00095 19.1 0.0 0.0021 18.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE39022.1 - 0.021 15.1 0.0 0.047 14.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 EFE39022.1 - 0.023 13.7 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.8 EFE39022.1 - 0.028 13.5 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.13 EFE39022.1 - 0.029 13.4 0.0 0.25 10.4 0.0 2.3 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Proteasome PF00227.21 EFE39024.1 - 3.2e-47 160.2 0.0 3.8e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 EFE39024.1 - 2e-14 52.5 0.0 4e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Microtub_assoc PF07989.6 EFE39025.1 - 0.096 12.5 0.1 3.4 7.5 0.0 2.4 1 1 1 2 2 2 0 Microtubule associated WD40 PF00400.27 EFE39025.1 - 0.11 12.3 0.1 3.3 7.7 0.0 3.3 4 0 0 4 4 4 0 WD domain, G-beta repeat Syntaxin-6_N PF09177.6 EFE39025.1 - 0.13 12.7 0.1 0.35 11.3 0.0 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Fungal_trans PF04082.13 EFE39026.1 - 3.2e-14 52.4 0.3 5.8e-14 51.5 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE39026.1 - 1.6e-07 31.0 9.4 3e-07 30.2 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_18 PF12847.2 EFE39027.1 - 0.022 15.3 0.0 0.042 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_1 PF00583.19 EFE39028.1 - 2.1e-09 37.2 0.1 3.9e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE39028.1 - 4.2e-07 30.0 0.0 9.5e-07 28.8 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE39028.1 - 8.9e-06 25.5 0.0 0.00018 21.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE39028.1 - 1.3e-05 25.3 0.0 2.1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.13 EFE39028.1 - 0.0087 15.3 0.0 0.039 13.1 0.0 1.8 2 0 0 2 2 2 1 MOZ/SAS family FR47 PF08445.5 EFE39028.1 - 0.017 14.8 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein DUF2890 PF11081.3 EFE39028.1 - 0.054 13.5 1.2 0.073 13.1 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Leu_leader PF08054.6 EFE39030.1 - 0.41 10.3 0.1 0.41 10.3 0.1 2.7 3 1 0 3 3 3 0 Leucine operon leader peptide DUF983 PF06170.7 EFE39030.1 - 8.5 6.5 7.3 2.9 8.0 0.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF983) FAM74 PF15026.1 EFE39031.1 - 0.08 12.5 0.0 0.083 12.5 0.0 1.1 1 0 0 1 1 1 0 FAM74 protein AA_permease_2 PF13520.1 EFE39032.1 - 1.9e-50 171.6 28.5 2.4e-50 171.3 19.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE39032.1 - 7e-23 80.7 26.8 8.3e-23 80.4 18.6 1.0 1 0 0 1 1 1 1 Amino acid permease KH_1 PF00013.24 EFE39033.1 - 2.4e-40 136.0 3.1 2.7e-16 58.9 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EFE39033.1 - 1.4e-30 104.3 10.0 2.2e-11 43.1 1.3 3.5 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EFE39033.1 - 2e-11 43.3 2.9 0.011 15.2 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EFE39033.1 - 0.00027 20.5 0.2 1.8 8.2 0.0 3.1 3 0 0 3 3 3 2 KH domain KH_5 PF13184.1 EFE39033.1 - 0.018 14.8 6.8 1.2 8.9 0.1 3.2 3 0 0 3 3 3 0 NusA-like KH domain CENP-K PF11802.3 EFE39034.1 - 0.00027 20.2 2.8 0.12 11.6 0.0 2.6 3 0 0 3 3 3 2 Centromere-associated protein K DUF3829 PF12889.2 EFE39034.1 - 0.071 12.2 5.3 0.23 10.6 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) DUF462 PF04315.7 EFE39034.1 - 0.12 11.7 0.3 11 5.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF462 Syntaxin-6_N PF09177.6 EFE39034.1 - 0.16 12.3 16.7 2.4 8.6 0.4 4.5 2 1 1 4 4 4 0 Syntaxin 6, N-terminal AAA_13 PF13166.1 EFE39034.1 - 0.53 8.6 11.6 0.34 9.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain Spc7 PF08317.6 EFE39034.1 - 1 7.9 14.6 0.18 10.4 6.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein ARD PF03079.9 EFE39034.1 - 3.3 7.6 8.3 0.4 10.6 1.6 2.2 2 0 0 2 2 2 0 ARD/ARD' family APG6 PF04111.7 EFE39034.1 - 3.8 6.4 15.3 0.69 8.8 2.8 2.7 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF2203 PF09969.4 EFE39034.1 - 4.8 7.4 10.2 3.7 7.7 2.4 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Abhydrolase_6 PF12697.2 EFE39035.1 - 6.6e-14 52.3 0.0 1.5e-13 51.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE39035.1 - 4.7e-10 39.4 0.0 7.4e-09 35.5 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE39035.1 - 5.7e-10 39.1 0.0 5.9e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 EFE39035.1 - 0.0066 15.8 0.0 0.025 14.0 0.0 1.8 2 0 0 2 2 2 1 Putative esterase Peptidase_S9 PF00326.16 EFE39035.1 - 0.025 13.8 0.0 0.075 12.2 0.0 1.8 1 1 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.3 EFE39035.1 - 0.071 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase Methyltransf_11 PF08241.7 EFE39036.1 - 1.8e-07 31.5 0.1 1.2e-05 25.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE39036.1 - 2.4e-07 30.4 0.0 4.2e-07 29.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE39036.1 - 2.2e-06 27.7 0.0 8.6e-05 22.5 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE39036.1 - 1.6e-05 24.1 0.0 9.4e-05 21.6 0.0 2.2 2 1 1 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFE39036.1 - 5e-05 23.5 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE39036.1 - 5.2e-05 23.8 0.0 0.00059 20.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE39036.1 - 0.00019 21.8 0.0 0.00036 20.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE39036.1 - 0.00099 18.5 0.0 0.0046 16.3 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase small domain FmrO PF07091.6 EFE39036.1 - 0.0074 15.3 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_23 PF13489.1 EFE39036.1 - 0.011 15.5 0.0 0.1 12.3 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 EFE39036.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SnoaL_2 PF12680.2 EFE39037.1 - 3.9e-05 24.0 0.0 7.1e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain DUF4342 PF14242.1 EFE39038.1 - 0.079 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) AMP-binding PF00501.23 EFE39039.1 - 3.3e-142 473.7 0.0 1.5e-83 280.4 0.2 2.4 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 EFE39039.1 - 9.5e-71 238.0 0.0 5.6e-35 120.6 0.0 2.3 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.20 EFE39039.1 - 1.1e-22 80.0 0.0 2.6e-11 43.6 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE39039.1 - 1e-08 35.9 0.0 0.0018 19.1 0.0 3.2 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain Beta-lactamase PF00144.19 EFE39040.1 - 7.8e-49 166.4 0.0 1.1e-48 165.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.3 EFE39040.1 - 0.00015 21.5 0.0 0.0012 18.6 0.0 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3471) SNF2_N PF00176.18 EFE39042.1 - 1.3e-49 168.6 0.0 1.9e-49 168.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE39042.1 - 5.1e-12 45.4 0.0 2.5e-11 43.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EFE39042.1 - 2e-06 26.8 0.0 9.4e-06 24.6 0.0 2.0 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Vac14_Fab1_bd PF12755.2 EFE39043.1 - 1.3e-45 153.6 0.1 4.3e-42 142.4 0.0 4.0 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region Vac14_Fig4_bd PF11916.3 EFE39043.1 - 4e-25 88.0 1.1 1.2e-24 86.4 0.1 2.0 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding HEAT PF02985.17 EFE39043.1 - 7.4e-08 31.8 1.4 0.11 12.6 0.0 7.0 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.1 EFE39043.1 - 7.3e-07 29.4 4.6 0.034 14.6 0.0 5.2 3 1 1 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.1 EFE39043.1 - 1.5e-05 25.1 2.0 0.049 13.9 0.0 4.1 4 0 0 4 4 4 2 HEAT repeats APH PF01636.18 EFE39044.1 - 2.6e-13 50.2 0.0 5.1e-13 49.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE39044.1 - 2.1e-05 23.3 0.1 0.00012 20.9 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.15 EFE39044.1 - 0.0015 17.7 0.0 0.0031 16.7 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase Glyco_hydro_47 PF01532.15 EFE39046.1 - 4.7e-168 559.5 0.0 5.5e-168 559.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 APG9 PF04109.11 EFE39047.1 - 2.4e-167 556.4 3.1 3.5e-167 555.9 2.2 1.2 1 0 0 1 1 1 1 Autophagy protein Apg9 SR-25 PF10500.4 EFE39048.1 - 0.011 15.2 7.8 0.01 15.2 5.4 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HrpJ PF07201.6 EFE39048.1 - 0.21 11.5 3.1 0.24 11.4 2.2 1.1 1 0 0 1 1 1 0 HrpJ-like domain DUF2956 PF11169.3 EFE39048.1 - 0.23 11.4 7.1 0.24 11.3 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) BLVR PF06375.6 EFE39048.1 - 0.28 10.9 4.8 0.28 10.9 3.4 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) C_GCAxxG_C_C PF09719.5 EFE39048.1 - 0.48 10.2 2.7 0.51 10.1 1.9 1.0 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) C2-set PF05790.10 EFE39048.1 - 0.52 10.3 2.3 0.63 10.0 1.6 1.2 1 0 0 1 1 1 0 Immunoglobulin C2-set domain SR-25 PF10500.4 EFE39049.1 - 0.0076 15.7 10.5 0.0076 15.7 7.3 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Folate_carrier PF01770.13 EFE39049.1 - 0.15 10.5 0.3 0.21 10.0 0.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier MIP-T3 PF10243.4 EFE39049.1 - 0.51 8.7 24.0 0.71 8.2 16.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PaREP1 PF05942.6 EFE39049.1 - 1.7 8.5 12.6 0.21 11.4 3.0 2.2 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family Consortin_C PF15281.1 EFE39049.1 - 5.1 6.6 12.9 0.041 13.3 1.5 2.0 2 0 0 2 2 2 0 Consortin C-terminus BRF1 PF07741.8 EFE39049.1 - 6.5 7.0 19.8 0.16 12.1 3.4 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain GAGA_bind PF06217.7 EFE39049.1 - 8 6.3 13.5 0.38 10.6 2.5 2.0 2 0 0 2 2 2 0 GAGA binding protein-like family DUF1764 PF08576.5 EFE39049.1 - 9 7.1 18.0 1.3 9.8 4.4 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) RRM_1 PF00076.17 EFE39050.1 - 9.8e-47 156.4 0.7 5.2e-14 51.6 0.5 5.4 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE39050.1 - 1e-39 134.3 0.1 1.2e-11 44.4 0.0 5.0 4 1 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39050.1 - 2.6e-18 65.6 0.0 0.004 16.9 0.0 5.2 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE39050.1 - 2e-06 27.4 0.0 0.00026 20.6 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Lsm_interact PF05391.6 EFE39050.1 - 0.29 10.6 1.8 0.5 9.8 0.1 2.3 2 0 0 2 2 2 0 Lsm interaction motif Fzo_mitofusin PF04799.8 EFE39051.1 - 0.93 8.8 3.8 1.8 7.9 2.7 1.5 1 1 0 1 1 1 0 fzo-like conserved region WD40 PF00400.27 EFE39053.1 - 3.8e-52 172.4 8.0 6.2e-12 44.9 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Tup_N PF08581.5 EFE39053.1 - 6.5e-09 35.8 0.6 0.00045 20.3 0.2 2.2 2 0 0 2 2 2 2 Tup N-terminal Cytochrom_D1 PF02239.11 EFE39053.1 - 9.8e-06 24.0 2.3 0.00031 19.1 0.3 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.3 EFE39053.1 - 0.0064 14.6 0.2 0.14 10.2 0.0 2.6 1 1 1 2 2 2 1 Nucleoporin Nup120/160 eIF2A PF08662.6 EFE39053.1 - 0.015 15.0 0.0 0.042 13.5 0.0 1.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 EFE39053.1 - 0.017 14.2 0.0 5.2 6.0 0.0 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.6 EFE39053.1 - 0.034 12.8 0.1 2.1 7.0 0.0 2.8 1 1 2 3 3 3 0 Nup133 N terminal like MMS1_N PF10433.4 EFE39053.1 - 0.23 9.5 0.0 7.8 4.5 0.0 2.3 1 1 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term FA_hydroxylase PF04116.8 EFE39054.1 - 1.2e-13 51.3 17.3 1.2e-13 51.3 12.0 2.4 2 1 0 2 2 2 2 Fatty acid hydroxylase superfamily MIF4G_like PF09088.6 EFE39055.1 - 8.3e-82 273.2 0.6 2.5e-81 271.6 0.1 2.0 2 0 0 2 2 2 1 MIF4G like MIF4G_like_2 PF09090.6 EFE39055.1 - 1.3e-58 198.1 0.1 1.8e-58 197.7 0.0 1.2 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.14 EFE39055.1 - 0.034 13.5 0.0 0.61 9.4 0.0 2.7 3 0 0 3 3 3 0 MIF4G domain MscS_TM PF12794.2 EFE39055.1 - 0.087 11.4 0.0 0.47 9.0 0.0 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Pkinase PF00069.20 EFE39056.1 - 2.7e-57 193.8 0.0 4.3e-57 193.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39056.1 - 2.6e-21 75.8 0.0 4.6e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE39056.1 - 1.3e-06 27.6 0.0 2.5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE39056.1 - 0.0054 16.5 0.0 0.017 14.8 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE39056.1 - 0.086 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4603 PF15376.1 EFE39057.1 - 5.4 4.0 13.8 6.6 3.7 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) OAD_gamma PF04277.8 EFE39058.1 - 0.0067 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain PBP_sp32 PF07222.7 EFE39058.1 - 1.9 7.6 7.3 2.2 7.3 5.1 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Trypan_PARP PF05887.6 EFE39058.1 - 3.6 7.4 11.3 4.5 7.0 7.8 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AA_permease_2 PF13520.1 EFE39059.1 - 1.2e-16 60.2 18.9 1.6e-16 59.9 13.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE39059.1 - 6.7e-06 24.7 15.5 8.9e-06 24.2 10.7 1.1 1 0 0 1 1 1 1 Amino acid permease YlaH PF14036.1 EFE39059.1 - 0.00069 19.6 3.1 0.0012 18.8 2.1 1.4 1 0 0 1 1 1 1 YlaH-like protein Presenilin PF01080.12 EFE39059.1 - 0.52 9.0 4.0 1.2 7.9 1.7 1.9 2 0 0 2 2 2 0 Presenilin AA_permease_2 PF13520.1 EFE39060.1 - 1.4e-21 76.5 19.1 1.6e-21 76.3 13.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE39060.1 - 1.8e-11 43.0 19.0 2.3e-11 42.7 13.1 1.1 1 0 0 1 1 1 1 Amino acid permease CBM_19 PF03427.8 EFE39060.1 - 0.031 14.0 0.6 0.071 12.8 0.4 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) APS_kinase PF01583.15 EFE39060.1 - 0.16 11.5 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Acetyltransf_3 PF13302.1 EFE39061.1 - 1.3e-18 67.5 0.0 2.8e-18 66.4 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE39061.1 - 2.2e-10 40.4 0.0 3.5e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 EFE39061.1 - 0.00018 21.4 0.1 0.00029 20.7 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE39061.1 - 0.0018 17.9 0.0 0.0035 17.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 EFE39061.1 - 0.092 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_hydro_47 PF01532.15 EFE39063.1 - 8e-140 466.4 0.0 9.1e-140 466.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Histidinol_dh PF00815.15 EFE39064.1 - 4.5e-137 457.0 6.4 4.5e-137 457.0 4.4 1.8 2 0 0 2 2 2 1 Histidinol dehydrogenase PRA-CH PF01502.13 EFE39064.1 - 9.8e-25 85.9 0.1 2e-24 84.9 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 EFE39064.1 - 2.3e-11 43.8 0.4 7.8e-11 42.0 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase DUF2122 PF09895.4 EFE39064.1 - 0.081 13.1 1.1 0.38 10.9 0.1 2.5 2 0 0 2 2 2 0 RecB-family nuclease (DUF2122) MazG PF03819.12 EFE39064.1 - 0.1 12.5 0.5 0.24 11.3 0.4 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Complex1_49kDa PF00346.14 EFE39065.1 - 5e-126 419.2 0.0 7.1e-126 418.7 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit RNA_pol_A_bac PF01000.21 EFE39066.1 - 2.7e-27 95.1 0.0 4.8e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EFE39066.1 - 7e-13 47.5 0.0 9.3e-13 47.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain E2_bind PF08825.5 EFE39067.1 - 5.2e-29 99.8 0.3 8.1e-29 99.2 0.2 1.3 1 0 0 1 1 1 1 E2 binding domain UBACT PF02134.16 EFE39067.1 - 1.4e-24 85.4 0.2 2.8e-24 84.4 0.1 1.5 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein ThiF PF00899.16 EFE39067.1 - 3e-22 78.9 0.0 7.6e-22 77.5 0.0 1.7 2 0 0 2 2 2 1 ThiF family UBA_e1_thiolCys PF10585.4 EFE39067.1 - 1.5e-14 53.1 2.2 1.5e-14 53.1 1.5 1.9 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site MoeZ_MoeB PF05237.8 EFE39067.1 - 0.00025 20.5 0.0 0.00052 19.5 0.0 1.5 1 0 0 1 1 1 1 MoeZ/MoeB domain UBA_e1_C PF09358.5 EFE39067.1 - 0.0012 19.0 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain Ecm33 PF12454.3 EFE39067.1 - 0.034 14.0 2.3 0.073 12.9 1.6 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Pro_dh PF01619.13 EFE39067.1 - 0.13 11.2 0.1 0.32 9.9 0.0 1.6 2 0 0 2 2 2 0 Proline dehydrogenase Telomere_reg-2 PF10193.4 EFE39068.1 - 6.4e-30 103.7 0.0 1.7e-29 102.3 0.0 1.8 1 0 0 1 1 1 1 Telomere length regulation protein Fungal_trans PF04082.13 EFE39069.1 - 3.6e-25 88.3 0.1 6.1e-25 87.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_2 PF00890.19 EFE39070.1 - 4.8e-46 157.4 0.1 3e-45 154.8 0.1 1.9 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 EFE39070.1 - 4.5e-08 32.6 0.3 7.7e-08 31.8 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.19 EFE39070.1 - 3.1e-07 29.6 1.2 2.9e-06 26.4 0.8 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EFE39070.1 - 7.8e-06 24.6 3.3 0.00064 18.3 0.1 3.1 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox_2 PF07992.9 EFE39070.1 - 2.8e-05 24.1 0.4 0.0012 18.7 0.1 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE39070.1 - 4.4e-05 23.6 0.2 0.0028 17.7 0.1 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFE39070.1 - 0.00079 18.5 0.0 0.0013 17.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 EFE39070.1 - 0.0019 17.1 0.4 0.0019 17.1 0.3 2.7 3 0 0 3 3 3 1 Glucose inhibited division protein A Thi4 PF01946.12 EFE39070.1 - 0.0022 17.1 0.0 0.0043 16.1 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.1 EFE39070.1 - 0.024 14.6 0.2 0.099 12.6 0.1 2.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 EFE39070.1 - 0.039 12.8 0.1 0.071 12.0 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.16 EFE39070.1 - 0.086 12.4 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PVL_ORF50 PF07768.6 EFE39072.1 - 0.016 15.2 9.1 0.019 14.9 6.3 1.1 1 0 0 1 1 1 0 PVL ORF-50-like family YqfQ PF14181.1 EFE39072.1 - 0.036 14.1 1.0 0.037 14.0 0.7 1.3 1 0 0 1 1 1 0 YqfQ-like protein Bap31 PF05529.7 EFE39072.1 - 0.043 13.2 0.1 0.052 12.9 0.1 1.0 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF2161 PF09929.4 EFE39072.1 - 0.064 13.1 2.0 0.069 13.0 1.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2161) Med2 PF11214.3 EFE39072.1 - 0.15 12.0 4.0 0.18 11.8 2.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 2 BLVR PF06375.6 EFE39072.1 - 0.31 10.8 12.2 0.37 10.6 8.4 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Peptidase_S49_N PF08496.5 EFE39072.1 - 0.31 10.8 6.9 0.36 10.5 4.8 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Med19 PF10278.4 EFE39072.1 - 0.75 9.4 14.0 0.89 9.2 9.7 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 ERK-JNK_inhib PF15002.1 EFE39072.1 - 1.1 8.6 9.0 1.2 8.4 6.2 1.2 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor Gyro_capsid PF04162.7 EFE39072.1 - 1.3 7.1 4.2 1.4 7.1 2.9 1.0 1 0 0 1 1 1 0 Gyrovirus capsid protein (VP1) SR-25 PF10500.4 EFE39072.1 - 2.7 7.4 15.9 3.2 7.1 11.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNase_H2-Ydr279 PF09468.5 EFE39072.1 - 4 6.5 9.4 4.7 6.3 6.5 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) NARP1 PF12569.3 EFE39072.1 - 4.6 5.8 8.6 5.3 5.6 6.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF788 PF05620.6 EFE39072.1 - 5.5 6.8 6.1 6.5 6.5 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF788) CMS1 PF14617.1 EFE39072.1 - 7.8 5.4 9.3 8.6 5.3 6.4 1.1 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Hpt PF01627.18 EFE39074.1 - 0.00013 21.9 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 Hpt domain Ribonuc_L-PSP PF01042.16 EFE39074.1 - 0.068 12.9 0.0 0.075 12.7 0.0 1.2 1 0 0 1 1 1 0 Endoribonuclease L-PSP BRE1 PF08647.6 EFE39074.1 - 0.12 12.3 0.1 0.14 12.1 0.1 1.1 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF4448 PF14610.1 EFE39075.1 - 1.2e-40 138.9 0.0 2.4e-40 138.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) dsrm PF00035.20 EFE39076.1 - 0.028 15.0 0.0 0.045 14.3 0.0 1.4 1 0 0 1 1 1 0 Double-stranded RNA binding motif Prenyltrans PF00432.16 EFE39077.1 - 5.8e-13 48.1 1.2 3.7e-07 29.5 0.3 3.0 3 0 0 3 3 3 2 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EFE39078.1 - 0.00055 20.3 0.1 0.0039 17.5 0.1 2.0 1 1 0 1 1 1 1 Prenyltransferase-like DUF3049 PF11250.3 EFE39078.1 - 0.087 12.6 0.0 16 5.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3049) Prenyltrans PF00432.16 EFE39078.1 - 1.1 8.8 9.6 4.9 6.8 1.8 2.4 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat Protocadherin PF08374.6 EFE39080.1 - 0.64 9.6 3.5 0.59 9.7 2.4 1.1 1 0 0 1 1 1 0 Protocadherin SR-25 PF10500.4 EFE39080.1 - 1.3 8.4 10.7 1.4 8.2 7.4 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NST1 PF13945.1 EFE39080.1 - 3.4 7.6 6.1 3.7 7.5 4.2 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator YqzE PF14038.1 EFE39080.1 - 4 7.2 5.2 0.76 9.5 0.5 1.9 2 0 0 2 2 2 0 YqzE-like protein Zn_clus PF00172.13 EFE39081.1 - 0.0039 17.0 7.8 0.0084 15.9 5.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CAF-1_p150 PF11600.3 EFE39081.1 - 2.6 7.3 6.6 5.8 6.2 4.6 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF2413 PF10310.4 EFE39082.1 - 4.8e-140 467.2 0.0 5.5e-140 467.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2413) Flu_M1_C PF08289.6 EFE39082.1 - 0.011 15.6 0.1 0.032 14.2 0.1 1.8 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain DUF3275 PF11679.3 EFE39082.1 - 4.3 6.9 6.4 3.3 7.2 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) OB_NTP_bind PF07717.11 EFE39084.1 - 1.3e-24 86.1 0.0 7.3e-23 80.5 0.0 2.6 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFE39084.1 - 3.7e-24 84.6 0.0 1.8e-23 82.4 0.0 2.3 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE39084.1 - 5.5e-14 51.7 0.0 1.9e-13 50.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE39084.1 - 7.4e-07 28.8 0.1 1.8e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 EFE39084.1 - 0.00058 18.8 0.0 0.0041 16.0 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.1 EFE39084.1 - 0.00075 19.6 0.1 0.0019 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 EFE39084.1 - 0.0021 17.9 0.0 0.69 9.7 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit KaiC PF06745.8 EFE39084.1 - 0.0066 15.5 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 KaiC DUF2075 PF09848.4 EFE39084.1 - 0.0077 15.2 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 EFE39084.1 - 0.011 15.6 0.2 0.067 13.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.17 EFE39084.1 - 0.021 14.3 0.2 0.059 12.8 0.2 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.9 EFE39084.1 - 0.05 13.3 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain NACHT PF05729.7 EFE39084.1 - 0.052 13.2 1.5 0.51 9.9 0.1 2.5 3 0 0 3 3 3 0 NACHT domain Glug PF07581.7 EFE39084.1 - 0.073 13.3 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 The GLUG motif AAA_23 PF13476.1 EFE39084.1 - 0.11 12.7 0.8 0.76 10.0 0.0 2.5 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.17 EFE39084.1 - 0.13 11.0 0.0 0.26 10.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.1 EFE39084.1 - 0.16 11.4 0.0 0.37 10.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RTC4 PF14474.1 EFE39085.1 - 1e-36 125.6 0.1 1.8e-36 124.8 0.0 1.4 1 0 0 1 1 1 1 RTC4-like domain DUF726 PF05277.7 EFE39086.1 - 5.2e-129 430.0 2.2 8.7e-129 429.3 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF726) NUDIX PF00293.23 EFE39087.1 - 1.6e-07 31.0 0.0 7.8e-07 28.8 0.0 1.8 1 1 0 1 1 1 1 NUDIX domain Metallophos PF00149.23 EFE39088.1 - 8.6e-12 44.8 1.2 2.1e-11 43.6 0.8 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE39088.1 - 1.8e-08 34.3 0.0 3.5e-08 33.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.1 EFE39088.1 - 0.12 11.5 0.0 0.47 9.5 0.0 1.8 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Mito_carr PF00153.22 EFE39089.1 - 1.2e-74 246.1 0.6 1.3e-25 88.9 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.27 EFE39089.1 - 1.3e-11 42.8 7.2 4.7e-07 28.6 0.1 5.4 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 EFE39089.1 - 1.4e-11 43.2 5.3 3.4e-07 29.5 0.1 5.5 6 0 0 6 6 6 2 EF-hand domain EF-hand_7 PF13499.1 EFE39089.1 - 5.9e-11 42.3 6.1 3.8e-08 33.3 0.7 4.0 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.1 EFE39089.1 - 5.3e-10 38.7 0.4 0.14 11.7 0.0 4.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 EFE39089.1 - 1.6e-06 27.1 8.4 4.1e-05 22.7 0.1 4.8 5 0 0 5 5 5 1 EF hand EF-hand_9 PF14658.1 EFE39089.1 - 0.12 12.2 0.0 11 6.0 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain Pyr_redox_3 PF13738.1 EFE39091.1 - 6.3e-24 85.1 0.0 9.7e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFE39091.1 - 1.2e-11 43.5 0.1 2.8e-10 39.0 0.0 2.6 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFE39091.1 - 3.4e-11 42.9 0.1 8.3e-08 32.1 0.0 3.3 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFE39091.1 - 6.8e-07 29.3 0.0 0.00022 21.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE39091.1 - 1e-06 27.9 0.3 3.9e-06 26.0 0.0 2.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 EFE39091.1 - 1.3e-06 27.5 0.1 0.0043 16.0 0.0 2.8 3 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFE39091.1 - 0.0001 22.0 0.5 0.64 9.7 0.2 4.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFE39091.1 - 0.0025 18.1 0.1 4.1 7.8 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFE39091.1 - 0.0054 15.8 0.4 0.027 13.5 0.0 2.0 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.15 EFE39091.1 - 0.01 15.9 0.0 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.7 EFE39091.1 - 0.028 13.3 0.0 1.6 7.5 0.0 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein FAD_binding_2 PF00890.19 EFE39091.1 - 0.031 13.1 0.0 0.25 10.1 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Glyco_transf_25 PF01755.12 EFE39092.1 - 4.1e-05 23.3 0.0 0.37 10.4 0.0 2.7 3 0 0 3 3 3 2 Glycosyltransferase family 25 (LPS biosynthesis protein) Peptidase_M22 PF00814.20 EFE39094.1 - 2.9e-45 154.8 0.0 2.7e-40 138.5 0.0 3.4 2 1 0 2 2 2 2 Glycoprotease family Myb_DNA-bind_6 PF13921.1 EFE39095.1 - 1.2e-08 34.9 1.4 9e-08 32.1 0.3 2.3 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFE39095.1 - 0.0066 16.4 0.1 0.059 13.4 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain AJAP1_PANP_C PF15298.1 EFE39096.1 - 0.04 13.7 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus zf-HC5HC2H_2 PF13832.1 EFE39097.1 - 6.5e-33 113.0 3.8 6.5e-33 113.0 2.6 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFE39097.1 - 7.6e-28 96.5 1.4 7.6e-28 96.5 1.0 2.8 3 0 0 3 3 3 1 PHD-like zinc-binding domain EPL1 PF10513.4 EFE39097.1 - 4.9e-24 85.3 0.0 4.9e-24 85.3 0.0 2.4 2 0 0 2 2 2 1 Enhancer of polycomb-like PHD_2 PF13831.1 EFE39097.1 - 5.3e-14 51.2 3.2 5.3e-14 51.2 2.2 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.24 EFE39097.1 - 5.1e-08 32.4 25.1 7.4e-08 31.9 6.9 2.7 2 0 0 2 2 2 2 PHD-finger Bromodomain PF00439.20 EFE39097.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Bromodomain RRM_1 PF00076.17 EFE39098.1 - 2.8e-20 71.7 0.0 3.6e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE39098.1 - 9.4e-19 67.1 0.0 1.2e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39098.1 - 1.5e-12 47.1 0.0 2e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dpy-30 PF05186.8 EFE39099.1 - 6.2e-05 22.3 0.0 9.2e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif VRR_NUC PF08774.6 EFE39100.1 - 1.2e-17 63.7 0.0 4.6e-17 61.8 0.0 2.1 2 0 0 2 2 2 1 VRR-NUC domain Ribosomal_S13_N PF08069.7 EFE39101.1 - 4.7e-29 100.0 0.1 8.5e-29 99.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 EFE39101.1 - 1.7e-18 66.1 0.1 3.2e-18 65.2 0.1 1.6 1 1 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.13 EFE39101.1 - 0.016 14.9 0.1 0.029 14.1 0.1 1.5 1 1 0 1 1 1 0 'Paired box' domain Chromate_transp PF02417.10 EFE39102.1 - 1.7e-27 96.1 26.6 7.2e-25 87.5 8.1 2.6 3 0 0 3 3 3 2 Chromate transporter Oxidored_q2 PF00420.19 EFE39102.1 - 5.4 6.6 7.1 0.61 9.7 0.2 2.9 3 2 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF2865 PF11064.3 EFE39104.1 - 0.053 13.3 0.3 0.06 13.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2865) DUF3082 PF11282.3 EFE39105.1 - 0.0091 16.0 0.2 0.026 14.5 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3082) Pkinase PF00069.20 EFE39108.1 - 1.2e-11 44.3 0.0 2.8e-11 43.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39108.1 - 6.9e-07 28.5 0.0 9.6e-06 24.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EFE39108.1 - 0.017 14.8 0.3 0.41 10.3 0.0 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 EFE39108.1 - 0.17 10.8 0.0 0.37 9.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Wbp11 PF09429.5 EFE39109.1 - 0.025 14.5 1.9 0.025 14.5 1.3 2.2 2 0 0 2 2 2 0 WW domain binding protein 11 ETS_PEA3_N PF04621.8 EFE39109.1 - 0.086 12.0 0.1 0.086 12.0 0.1 1.6 2 0 0 2 2 2 0 PEA3 subfamily ETS-domain transcription factor N terminal domain WD40 PF00400.27 EFE39111.1 - 2.6e-27 93.6 3.1 7.5e-08 31.9 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat Gmad1 PF10647.4 EFE39111.1 - 0.00078 18.9 0.0 0.0028 17.1 0.0 1.7 1 1 1 2 2 2 1 Lipoprotein LpqB beta-propeller domain Nup160 PF11715.3 EFE39111.1 - 0.016 13.3 0.6 0.14 10.2 0.1 2.2 2 1 0 2 2 2 0 Nucleoporin Nup120/160 FTHFS PF01268.14 EFE39112.1 - 8.5e-253 839.3 0.0 1.3e-252 838.7 0.0 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 EFE39112.1 - 6.4e-67 223.6 0.7 6.4e-67 223.6 0.5 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 EFE39112.1 - 1.8e-27 95.6 0.1 4.2e-27 94.5 0.1 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain RTC_insert PF05189.8 EFE39114.1 - 1.1e-32 112.0 0.0 2e-32 111.2 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.16 EFE39114.1 - 4.1e-32 110.7 0.1 5.9e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Peptidase_S9 PF00326.16 EFE39115.1 - 1.2e-50 171.7 0.0 1.9e-50 171.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFE39115.1 - 9.9e-10 38.3 0.0 2.4e-09 37.0 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE39115.1 - 7.4e-07 29.2 0.2 3.6e-06 27.0 0.1 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.7 EFE39115.1 - 0.0001 20.9 0.0 0.022 13.2 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Sec63 PF02889.11 EFE39116.1 - 1.3e-187 622.5 0.2 1.4e-106 356.2 0.0 2.6 2 1 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 EFE39116.1 - 1.9e-51 173.9 0.7 2.4e-30 105.2 0.0 3.6 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.10 EFE39116.1 - 9.7e-15 54.8 0.0 2.5e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EFE39116.1 - 3.3e-10 39.6 0.0 1.8e-09 37.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EFE39116.1 - 1.2e-05 25.4 0.4 0.0019 18.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain PhoH PF02562.11 EFE39116.1 - 0.00043 19.5 0.0 0.052 12.7 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_10 PF12846.2 EFE39116.1 - 0.011 15.1 0.0 3.6 6.9 0.0 2.9 3 0 0 3 3 3 0 AAA-like domain FtsK_SpoIIIE PF01580.13 EFE39116.1 - 0.015 14.7 0.0 0.08 12.4 0.0 2.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SE PF00437.15 EFE39116.1 - 0.02 13.7 0.0 1.5 7.6 0.0 2.6 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_19 PF13245.1 EFE39116.1 - 0.033 13.9 0.0 1.4 8.7 0.0 2.8 2 0 0 2 2 2 0 Part of AAA domain MutS_V PF00488.16 EFE39117.1 - 9.9e-85 283.6 0.0 1.6e-84 283.0 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFE39117.1 - 4.4e-27 95.1 0.0 4.6e-25 88.6 0.0 2.6 1 1 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EFE39117.1 - 7e-23 80.8 0.0 1.7e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 EFE39117.1 - 4.8e-08 33.1 0.0 1.8e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 EFE39117.1 - 9.5e-06 25.7 0.3 3.4e-05 23.9 0.1 2.1 2 0 0 2 2 2 1 MutS family domain IV AAA_23 PF13476.1 EFE39117.1 - 0.022 15.1 0.7 0.47 10.7 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EFE39117.1 - 0.024 14.1 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 EFE39117.1 - 0.027 14.6 0.1 0.34 11.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.1 EFE39117.1 - 0.033 14.0 0.0 0.11 12.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain Ureidogly_hydro PF04115.7 EFE39118.1 - 2.8e-50 169.8 0.0 3.7e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Ureidoglycolate hydrolase Catalase PF00199.14 EFE39119.1 - 1.3e-150 501.3 0.9 1.7e-150 501.0 0.6 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EFE39119.1 - 3.1e-14 52.5 0.3 6.6e-14 51.5 0.0 1.7 2 0 0 2 2 2 1 Catalase-related immune-responsive Rer1 PF03248.8 EFE39120.1 - 8.2e-49 165.5 5.1 9.6e-49 165.3 3.5 1.1 1 0 0 1 1 1 1 Rer1 family ECH PF00378.15 EFE39121.1 - 4.6e-72 242.0 0.2 5.6e-72 241.7 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 EFE39121.1 - 0.019 15.0 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 2-enoyl-CoA Hydratase C-terminal region adh_short PF00106.20 EFE39123.1 - 4.1e-19 69.1 0.1 6.2e-19 68.5 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE39123.1 - 1.4e-09 38.0 0.2 1.8e-09 37.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE39123.1 - 3e-09 36.8 0.1 3.9e-09 36.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE39123.1 - 0.0031 16.9 0.0 0.0047 16.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3623 PF12291.3 EFE39123.1 - 0.11 11.5 0.3 0.16 10.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3623) BTB PF00651.26 EFE39124.1 - 3.6e-15 55.9 0.1 1.2e-14 54.1 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain A_deaminase PF00962.17 EFE39125.1 - 1.2e-42 146.0 0.0 2.3e-37 128.6 0.0 2.5 2 1 0 2 2 2 2 Adenosine/AMP deaminase Acetyltransf_10 PF13673.1 EFE39126.1 - 6.4e-07 29.5 0.0 0.00075 19.5 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFE39126.1 - 0.00043 20.3 0.0 0.0063 16.6 0.0 2.4 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE39126.1 - 0.025 14.6 0.1 0.071 13.1 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family CFEM PF05730.6 EFE39129.1 - 5.3e-16 58.1 9.9 7.5e-16 57.7 6.8 1.2 1 0 0 1 1 1 1 CFEM domain MGC-24 PF05283.6 EFE39129.1 - 0.45 10.2 16.2 0.63 9.8 11.2 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) ATP-grasp_2 PF08442.5 EFE39130.1 - 1.6e-07 30.9 0.0 2.5e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Phage_1_1 PF08200.6 EFE39130.1 - 0.52 10.5 6.8 0.98 9.6 4.7 1.4 1 0 0 1 1 1 0 Bacteriophage 1.1 Protein Citrate_synt PF00285.16 EFE39131.1 - 1.2e-13 50.5 0.0 3.9e-10 39.0 0.1 4.0 2 1 1 3 3 3 2 Citrate synthase Ligase_CoA PF00549.14 EFE39131.1 - 5.6e-13 48.7 0.1 1e-12 47.9 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.14 EFE39131.1 - 2.8e-11 43.7 0.1 1.1e-10 41.8 0.0 2.1 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.1 EFE39131.1 - 1.2e-05 24.9 0.0 0.00012 21.7 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain RNase_P_Rpp14 PF01900.14 EFE39132.1 - 5.5e-37 125.9 0.0 6.9e-37 125.6 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family ATP_bind_1 PF03029.12 EFE39133.1 - 7.6e-13 48.5 0.0 1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Polysacc_deac_2 PF04748.8 EFE39133.1 - 0.019 13.9 0.0 0.023 13.7 0.0 1.1 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase ATP_bind_1 PF03029.12 EFE39134.1 - 3.3e-33 115.2 0.0 3.7e-33 115.0 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 EFE39134.1 - 0.00011 21.7 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 AAA-like domain ArgK PF03308.11 EFE39134.1 - 0.00028 19.7 0.0 0.00039 19.2 0.0 1.1 1 0 0 1 1 1 1 ArgK protein AAA_17 PF13207.1 EFE39134.1 - 0.0005 20.8 0.1 0.00071 20.3 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFE39134.1 - 0.0024 17.3 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain KTI12 PF08433.5 EFE39134.1 - 0.0041 16.3 0.0 0.0047 16.1 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 EFE39134.1 - 0.0092 15.8 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE39134.1 - 0.0092 15.9 0.0 0.016 15.1 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 EFE39134.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain RNA_helicase PF00910.17 EFE39134.1 - 0.014 15.5 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 RNA helicase Fer4_NifH PF00142.13 EFE39134.1 - 0.021 14.0 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Zeta_toxin PF06414.7 EFE39134.1 - 0.033 13.2 0.0 0.039 13.0 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.1 EFE39134.1 - 0.038 13.5 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EFE39134.1 - 0.048 13.2 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFE39134.1 - 0.05 13.3 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 EFE39134.1 - 0.054 13.6 0.0 0.057 13.5 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFE39134.1 - 0.055 13.3 0.0 0.066 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFE39134.1 - 0.081 12.3 0.0 0.092 12.2 0.0 1.5 1 1 0 1 1 1 0 FtsK/SpoIIIE family AAA_5 PF07728.9 EFE39134.1 - 0.086 12.5 0.0 0.12 12.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SE PF00437.15 EFE39134.1 - 0.09 11.6 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 EFE39134.1 - 0.099 12.9 0.1 0.12 12.6 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 EFE39134.1 - 0.11 12.6 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFE39134.1 - 0.11 11.4 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus SRP54 PF00448.17 EFE39134.1 - 0.12 11.7 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.16 EFE39134.1 - 0.15 11.2 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_13 PF13166.1 EFE39134.1 - 0.16 10.4 0.1 7 4.9 0.0 1.9 1 1 1 2 2 2 0 AAA domain WD40 PF00400.27 EFE39135.1 - 9.7e-17 60.1 0.5 0.00085 19.1 0.0 5.8 5 1 0 5 5 5 3 WD domain, G-beta repeat DUF1961 PF09224.6 EFE39135.1 - 0.048 12.7 0.0 0.091 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1961) HNH_2 PF13391.1 EFE39136.1 - 2e-16 59.5 0.0 4.3e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease AMP-binding PF00501.23 EFE39138.1 - 4.8e-153 509.4 0.0 8.7e-82 274.7 0.0 3.2 2 1 1 3 3 3 3 AMP-binding enzyme Condensation PF00668.15 EFE39138.1 - 2.4e-105 351.6 0.0 5.3e-40 137.1 0.0 3.3 3 0 0 3 3 3 3 Condensation domain PP-binding PF00550.20 EFE39138.1 - 1.2e-29 102.3 2.3 4e-11 43.0 0.0 3.9 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE39138.1 - 1.7e-11 44.8 0.0 6e-07 30.3 0.0 3.3 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain AATase PF07247.7 EFE39138.1 - 0.0064 15.0 0.0 0.078 11.5 0.0 2.3 2 0 0 2 2 2 1 Alcohol acetyltransferase HxxPF_rpt PF13745.1 EFE39138.1 - 0.012 15.9 0.0 0.05 13.9 0.0 2.1 1 0 0 1 1 1 0 HxxPF-repeated domain GH3 PF03321.8 EFE39138.1 - 2.3 6.6 3.8 4.6 5.6 0.0 2.9 4 0 0 4 4 4 0 GH3 auxin-responsive promoter AMP-binding PF00501.23 EFE39139.1 - 5.8e-246 815.5 0.0 4.4e-85 285.5 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.15 EFE39139.1 - 1.5e-130 434.4 0.0 7e-48 163.0 0.0 6.2 6 1 0 6 6 6 5 Condensation domain PP-binding PF00550.20 EFE39139.1 - 6.1e-28 96.8 1.3 2.3e-09 37.3 0.0 3.8 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE39139.1 - 1.8e-16 60.8 0.0 8.6e-06 26.6 0.0 3.8 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain p450 PF00067.17 EFE39140.1 - 6.9e-61 206.1 0.0 8.9e-61 205.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Acyl_transf_1 PF00698.16 EFE39141.1 - 3.8e-58 197.3 0.0 9.3e-56 189.4 0.0 3.4 4 0 0 4 4 4 1 Acyl transferase domain DUF1729 PF08354.5 EFE39141.1 - 7e-29 99.3 0.1 1.9e-28 97.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 EFE39141.1 - 1.1e-25 89.9 0.0 3.5e-24 85.0 0.0 2.5 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.14 EFE39141.1 - 3.1e-24 84.7 0.1 6.2e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain NMO PF03060.10 EFE39141.1 - 0.00087 18.5 0.0 0.079 12.0 0.0 2.6 2 1 0 2 2 2 2 Nitronate monooxygenase 4HBT_2 PF13279.1 EFE39142.1 - 4e-08 33.7 0.0 7.3e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily Viral_DNA_Zn_bi PF03728.8 EFE39142.1 - 0.026 14.6 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 Viral DNA-binding protein, zinc binding domain RTA1 PF04479.8 EFE39143.1 - 7.1e-30 104.1 2.8 1.2e-29 103.4 1.9 1.3 1 0 0 1 1 1 1 RTA1 like protein ABC_tran PF00005.22 EFE39144.1 - 2.6e-46 157.3 0.0 9.1e-26 90.7 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFE39144.1 - 1.3e-33 116.6 13.2 5.6e-21 75.1 2.7 2.5 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 EFE39144.1 - 3.9e-12 45.8 4.2 0.00092 18.4 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE39144.1 - 7e-12 45.9 1.1 0.078 12.9 0.1 4.3 4 0 0 4 4 4 4 AAA domain AAA_29 PF13555.1 EFE39144.1 - 7.1e-09 35.0 1.2 0.00078 18.9 0.0 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 EFE39144.1 - 3.5e-07 29.5 0.4 0.017 14.2 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 EFE39144.1 - 4.7e-07 29.9 0.1 0.027 14.4 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 EFE39144.1 - 3.6e-06 27.4 0.0 0.034 14.6 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_23 PF13476.1 EFE39144.1 - 1.3e-05 25.6 0.1 0.09 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFE39144.1 - 3.1e-05 23.9 0.0 0.11 12.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.1 EFE39144.1 - 5.8e-05 23.2 0.1 0.22 11.6 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.1 EFE39144.1 - 0.00017 21.0 0.0 0.075 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFE39144.1 - 0.00055 20.7 2.3 0.36 11.6 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EFE39144.1 - 0.00057 19.6 0.3 14 5.3 0.0 4.6 4 1 0 4 4 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 EFE39144.1 - 0.00058 19.7 0.0 1.2 9.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EFE39144.1 - 0.0017 18.0 0.5 0.31 10.6 0.0 3.7 4 0 0 4 4 4 1 NACHT domain AAA PF00004.24 EFE39144.1 - 0.0021 18.2 0.4 2.9 8.0 0.0 3.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 EFE39144.1 - 0.0025 17.9 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NB-ARC PF00931.17 EFE39144.1 - 0.0029 16.5 4.0 0.033 13.0 0.1 3.2 3 1 0 3 3 3 1 NB-ARC domain AAA_15 PF13175.1 EFE39144.1 - 0.0029 16.7 0.1 0.19 10.7 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 EFE39144.1 - 0.0036 17.6 0.0 0.83 9.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.18 EFE39144.1 - 0.0037 17.1 0.5 2.7 7.7 0.0 2.6 2 0 0 2 2 2 1 Dynamin family AAA_10 PF12846.2 EFE39144.1 - 0.0044 16.5 1.3 0.2 11.0 0.1 2.4 2 0 0 2 2 2 1 AAA-like domain T2SE PF00437.15 EFE39144.1 - 0.0058 15.5 0.1 3.2 6.5 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Sigma54_activat PF00158.21 EFE39144.1 - 0.0075 15.7 0.0 0.13 11.7 0.0 2.7 3 0 0 3 3 2 1 Sigma-54 interaction domain Arch_ATPase PF01637.13 EFE39144.1 - 0.0085 15.8 0.2 0.045 13.4 0.0 2.1 2 0 0 2 2 2 1 Archaeal ATPase MobB PF03205.9 EFE39144.1 - 0.0087 15.7 0.9 2.7 7.6 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B DUF815 PF05673.8 EFE39144.1 - 0.014 14.3 0.1 0.55 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NTPase_1 PF03266.10 EFE39144.1 - 0.02 14.6 0.3 4.1 7.0 0.1 2.5 2 0 0 2 2 2 0 NTPase ATP-synt_ab PF00006.20 EFE39144.1 - 0.027 13.9 0.3 7.7 5.9 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.7 EFE39144.1 - 0.04 13.0 0.1 4.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_14 PF13173.1 EFE39144.1 - 0.062 13.2 0.3 0.91 9.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain Gtr1_RagA PF04670.7 EFE39144.1 - 0.086 11.9 0.1 0.17 10.9 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 EFE39144.1 - 0.1 12.0 0.5 2.3 7.7 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.14 EFE39144.1 - 0.1 12.0 0.6 0.88 8.9 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Hairy_orange PF07527.8 EFE39144.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Hairy Orange FtsK_SpoIIIE PF01580.13 EFE39144.1 - 0.12 11.8 0.1 4.9 6.5 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF502 PF04367.8 EFE39144.1 - 0.14 11.9 4.3 8.1 6.2 0.3 2.9 3 0 0 3 3 2 0 Protein of unknown function (DUF502) AIG1 PF04548.11 EFE39144.1 - 0.18 10.8 0.9 7.1 5.6 0.0 2.9 3 0 0 3 3 3 0 AIG1 family Septin PF00735.13 EFE39144.1 - 0.31 10.0 0.1 21 4.0 0.0 2.2 2 0 0 2 2 2 0 Septin Guanylate_kin PF00625.16 EFE39144.1 - 0.38 10.1 0.7 13 5.2 0.1 2.4 2 0 0 2 2 2 0 Guanylate kinase Aminotran_4 PF01063.14 EFE39145.1 - 1.3e-23 83.6 0.0 3.5e-22 79.0 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class IV adh_short_C2 PF13561.1 EFE39146.1 - 4.9e-39 134.5 0.0 9.3e-39 133.6 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ketoacyl-synt PF00109.21 EFE39146.1 - 1.4e-18 67.2 0.0 3.1e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EFE39146.1 - 1.9e-11 43.8 0.0 4.1e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Rib_5-P_isom_A PF06026.9 EFE39147.1 - 1.9e-36 124.9 0.0 9.3e-35 119.4 0.0 2.1 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) ThiF PF00899.16 EFE39148.1 - 0.00052 19.8 0.0 0.002 17.9 0.0 1.9 2 0 0 2 2 2 1 ThiF family Asp PF00026.18 EFE39150.1 - 5.5e-07 29.1 0.0 7.9e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Syndecan PF01034.15 EFE39150.1 - 0.084 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Mid2 PF04478.7 EFE39150.1 - 0.12 11.8 0.4 0.43 9.9 0.1 2.0 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor SKG6 PF08693.5 EFE39150.1 - 0.61 9.4 4.5 1.4 8.3 3.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Cation_efflux PF01545.16 EFE39151.1 - 2.4e-38 131.8 7.6 4.8e-38 130.8 5.3 1.4 1 1 0 1 1 1 1 Cation efflux family MARVEL PF01284.18 EFE39151.1 - 7.3e-05 22.6 0.5 0.33 10.7 0.0 2.5 2 1 0 2 2 2 2 Membrane-associating domain EphA2_TM PF14575.1 EFE39151.1 - 0.17 12.3 1.3 3.5 8.0 0.0 3.1 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Zip PF02535.17 EFE39151.1 - 8.9 5.2 26.5 29 3.5 17.8 2.2 1 1 0 1 1 1 0 ZIP Zinc transporter zf-MYND PF01753.13 EFE39152.1 - 2.8e-08 33.5 8.0 2.8e-08 33.5 5.5 1.8 2 0 0 2 2 2 1 MYND finger Ion_trans PF00520.26 EFE39152.1 - 9.7e-08 31.4 12.2 2.1e-07 30.4 8.5 1.6 1 0 0 1 1 1 1 Ion transport protein DUF605 PF04652.11 EFE39152.1 - 1.8 7.8 14.2 3.5 6.9 9.8 1.4 1 0 0 1 1 1 0 Vta1 like Dicty_REP PF05086.7 EFE39152.1 - 4 5.0 3.6 6.1 4.4 2.5 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF1673 PF07895.6 EFE39152.1 - 4.3 6.8 6.5 22 4.4 2.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) Cyclin PF08613.6 EFE39154.1 - 1.4e-13 51.5 0.0 1.4e-13 51.5 0.0 2.3 3 0 0 3 3 3 1 Cyclin Cyclin_N PF00134.18 EFE39154.1 - 0.0029 17.1 0.0 0.0061 16.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Aminotran_4 PF01063.14 EFE39155.1 - 5.7e-21 75.0 0.0 6.8e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Sugar_tr PF00083.19 EFE39156.1 - 7.4e-83 278.5 20.3 9e-83 278.3 14.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE39156.1 - 6.2e-13 48.1 41.0 1.2e-09 37.3 21.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CDC14 PF08045.6 EFE39157.1 - 2.6e-99 331.5 0.0 4.8e-99 330.6 0.0 1.4 2 0 0 2 2 2 1 Cell division control protein 14, SIN component Methyltransf_18 PF12847.2 EFE39158.1 - 1.5e-15 57.7 0.0 2.3e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE39158.1 - 6.4e-15 55.4 0.0 1.1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE39158.1 - 4.6e-14 52.2 0.0 6.1e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE39158.1 - 4.6e-13 49.4 0.0 7.4e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE39158.1 - 1.9e-11 43.9 0.0 2.6e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE39158.1 - 1.4e-09 38.2 0.0 2.3e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE39158.1 - 5.6e-07 29.0 0.0 5.1e-06 25.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 EFE39158.1 - 3.9e-06 26.8 0.1 8.9e-06 25.7 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE39158.1 - 4.7e-06 25.8 0.0 7e-06 25.3 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EFE39158.1 - 9.9e-05 21.4 0.0 0.00021 20.4 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.15 EFE39158.1 - 0.001 18.2 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.9 EFE39158.1 - 0.0013 17.9 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB PCMT PF01135.14 EFE39158.1 - 0.0063 16.0 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.15 EFE39158.1 - 0.0075 15.3 0.0 0.0095 14.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF938 PF06080.7 EFE39158.1 - 0.014 14.9 0.0 0.033 13.7 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF938) FmrO PF07091.6 EFE39158.1 - 0.042 12.8 0.0 0.064 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) ADH_zinc_N PF00107.21 EFE39158.1 - 0.051 13.1 0.1 0.46 10.0 0.1 2.3 1 1 0 1 1 1 0 Zinc-binding dehydrogenase DOT1 PF08123.8 EFE39158.1 - 0.064 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_32 PF13679.1 EFE39158.1 - 0.064 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_7 PF03492.10 EFE39158.1 - 0.084 11.6 0.0 0.18 10.5 0.0 1.5 2 0 0 2 2 2 0 SAM dependent carboxyl methyltransferase GidB PF02527.10 EFE39158.1 - 0.12 11.4 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G DUF2731 PF10806.3 EFE39159.1 - 3.6e-05 24.0 0.0 0.00011 22.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2731) GST_C_2 PF13410.1 EFE39159.1 - 5.9e-05 22.8 0.1 0.00015 21.5 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain PBP1_TM PF14812.1 EFE39159.1 - 0.055 13.7 14.6 0.12 12.6 10.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.7 EFE39159.1 - 0.33 8.8 6.8 0.39 8.5 4.7 1.1 1 0 0 1 1 1 0 Nop14-like family Tom37_C PF11801.3 EFE39159.1 - 2.4 7.9 9.0 1.5 8.6 0.2 3.1 2 1 1 3 3 3 0 Tom37 C-terminal domain CENP-B_dimeris PF09026.5 EFE39159.1 - 6 7.1 14.4 12 6.1 10.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.4 EFE39159.1 - 7.9 5.0 22.1 12 4.5 15.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.8 EFE39159.1 - 8.2 4.0 11.9 14 3.2 8.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi CDK5_activator PF03261.10 EFE39160.1 - 0.29 10.4 5.4 0.72 9.1 3.7 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein MAP65_ASE1 PF03999.7 EFE39160.1 - 0.34 9.4 9.2 0.54 8.7 6.4 1.4 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Mitofilin PF09731.4 EFE39160.1 - 0.65 8.5 6.6 0.84 8.2 4.6 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Pex16 PF08610.5 EFE39160.1 - 0.94 8.4 3.5 1.4 7.8 2.4 1.4 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Urb2 PF10441.4 EFE39162.1 - 3.1e-60 203.5 5.9 5.3e-60 202.8 0.0 3.6 5 0 0 5 5 5 1 Urb2/Npa2 family Erf4 PF10256.4 EFE39162.1 - 0.029 14.2 0.0 0.11 12.3 0.0 2.0 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family A_deaminase PF00962.17 EFE39163.1 - 3.4e-21 75.5 0.0 4.6e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase p450 PF00067.17 EFE39164.1 - 3.7e-77 259.8 0.0 4.4e-77 259.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fer4_12 PF13353.1 EFE39164.1 - 0.065 13.3 0.1 0.33 11.0 0.0 2.1 2 1 0 2 2 2 0 4Fe-4S single cluster domain DUF3951 PF13131.1 EFE39164.1 - 0.11 12.3 1.0 0.25 11.1 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) APH PF01636.18 EFE39166.1 - 8.8e-09 35.4 0.5 4.4e-06 26.6 0.2 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase PF00069.20 EFE39166.1 - 1.1e-07 31.2 0.0 2.6e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39166.1 - 1.6e-07 30.6 0.0 2.9e-07 29.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE39166.1 - 0.00096 18.1 0.0 0.0019 17.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.17 EFE39166.1 - 0.078 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.6 EFE39166.1 - 0.13 11.0 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.27 EFE39167.1 - 6.6e-73 238.2 18.9 3.9e-12 45.5 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 EFE39167.1 - 2.2e-10 39.2 1.3 0.002 16.3 0.0 4.3 4 2 1 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFE39167.1 - 9e-06 24.6 0.0 0.0054 15.5 0.0 3.0 2 1 0 2 2 2 2 Nup133 N terminal like DSPc PF00782.15 EFE39168.1 - 1.1e-11 44.4 0.0 2.1e-11 43.5 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.7 EFE39168.1 - 0.0039 16.1 0.0 0.0049 15.8 0.0 1.1 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase SNF2_N PF00176.18 EFE39170.1 - 8.3e-70 234.9 0.0 1.9e-69 233.7 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE39170.1 - 6.2e-16 58.0 2.1 9.8e-16 57.3 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain BRF1 PF07741.8 EFE39170.1 - 1.1 9.4 22.7 1.3 9.3 8.8 3.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain End3 PF12761.2 EFE39171.1 - 2.8e-77 258.7 1.3 3.9e-77 258.3 0.9 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.2 EFE39171.1 - 1.9e-51 172.1 0.1 3.7e-49 164.7 0.0 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 EFE39171.1 - 1e-07 30.7 0.2 3.9e-07 28.8 0.1 2.1 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 EFE39171.1 - 5.3e-06 25.9 0.2 2.8e-05 23.6 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 EFE39171.1 - 8.7e-06 25.1 0.1 0.00024 20.7 0.2 2.8 3 0 0 3 3 2 1 EF-hand domain EF-hand_7 PF13499.1 EFE39171.1 - 1.7e-05 24.8 0.2 0.00019 21.5 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 EFE39171.1 - 0.00078 18.6 1.0 0.0026 17.0 0.2 2.3 2 0 0 2 2 2 1 EF hand DUF4407 PF14362.1 EFE39171.1 - 0.0014 17.6 3.9 0.0022 17.0 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) NPV_P10 PF05531.7 EFE39171.1 - 0.013 15.7 0.2 0.19 12.0 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Rabaptin PF03528.10 EFE39171.1 - 0.023 14.5 6.7 0.14 12.0 4.4 2.5 2 1 0 2 2 1 0 Rabaptin Phage_GP20 PF06810.6 EFE39171.1 - 0.024 14.0 3.0 0.033 13.6 0.3 2.2 2 0 0 2 2 2 0 Phage minor structural protein GP20 Med9 PF07544.8 EFE39171.1 - 0.039 13.6 0.7 0.039 13.6 0.5 2.5 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 COG2 PF06148.6 EFE39171.1 - 0.14 12.0 3.2 1 9.1 0.4 2.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TMF_DNA_bd PF12329.3 EFE39171.1 - 0.19 11.5 6.0 0.45 10.3 0.6 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Laminin_I PF06008.9 EFE39171.1 - 0.24 10.6 8.8 1.1 8.5 6.1 2.1 1 1 0 1 1 1 0 Laminin Domain I Spc7 PF08317.6 EFE39171.1 - 0.63 8.6 7.1 2.1 6.9 4.5 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein IncA PF04156.9 EFE39171.1 - 1.6 8.3 5.7 19 4.7 2.7 2.3 2 0 0 2 2 2 0 IncA protein DUF4201 PF13870.1 EFE39171.1 - 3.1 7.2 8.9 0.75 9.2 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Pkinase PF00069.20 EFE39173.1 - 4.3e-06 26.0 0.0 5.4e-06 25.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain MFS_1 PF07690.11 EFE39175.1 - 1.5e-33 116.0 20.8 1.5e-33 116.0 14.4 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Yae1_N PF09811.4 EFE39176.1 - 1.1e-12 47.2 0.2 2.2e-12 46.2 0.2 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal SCO1-SenC PF02630.9 EFE39178.1 - 4.8e-58 195.6 0.0 5.6e-58 195.3 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 EFE39178.1 - 5.4e-05 22.8 0.0 8.8e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 EFE39178.1 - 0.0019 18.2 0.0 0.0031 17.6 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like MoaE PF02391.12 EFE39179.1 - 4.9e-28 97.2 0.0 6e-28 96.9 0.0 1.1 1 0 0 1 1 1 1 MoaE protein SLAC1 PF03595.12 EFE39180.1 - 6.3e-60 202.5 29.8 7e-60 202.4 20.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Caerin_1 PF07440.7 EFE39180.1 - 0.12 12.2 2.3 7.4 6.5 0.8 2.5 2 0 0 2 2 2 0 Caerin 1 protein SLAC1 PF03595.12 EFE39181.1 - 2e-38 131.9 18.7 2.3e-38 131.6 13.0 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF161 PF02588.10 EFE39181.1 - 0.038 14.2 4.9 0.074 13.3 3.4 1.4 1 0 0 1 1 1 0 Uncharacterized BCR, YitT family COG1284 FAD_binding_3 PF01494.14 EFE39183.1 - 2.7e-13 49.7 0.0 7.1e-13 48.3 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFE39183.1 - 2.4e-05 23.4 0.1 0.00017 20.6 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE39183.1 - 9.5e-05 22.3 0.0 0.00024 21.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 EFE39183.1 - 0.00025 19.8 0.7 0.00033 19.4 0.1 1.5 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_2 PF07992.9 EFE39183.1 - 0.015 15.1 0.2 0.038 13.8 0.1 1.7 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFE39183.1 - 0.026 14.2 0.0 0.058 13.1 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF1967 PF09269.6 EFE39183.1 - 0.041 13.5 1.0 0.14 11.8 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) FAD_oxidored PF12831.2 EFE39183.1 - 0.15 11.0 0.7 0.26 10.3 0.5 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.17 EFE39183.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A EI24 PF07264.6 EFE39185.1 - 0.00054 19.4 10.4 0.0025 17.2 7.2 2.0 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Nif11 PF07862.6 EFE39185.1 - 0.07 13.0 0.0 2.5 8.1 0.0 2.6 3 0 0 3 3 3 0 Nitrogen fixation protein of unknown function PA PF02225.17 EFE39186.1 - 5.8e-11 41.9 0.0 1.3e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-RING_2 PF13639.1 EFE39186.1 - 2.6e-08 33.5 2.1 4.5e-08 32.7 1.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFE39186.1 - 4.8e-05 23.2 1.1 8.4e-05 22.5 0.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE39186.1 - 0.00017 21.1 0.9 0.00029 20.4 0.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE39186.1 - 0.00033 20.3 0.3 0.00058 19.5 0.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFE39186.1 - 0.0024 17.4 1.2 0.0039 16.8 0.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFE39186.1 - 0.0053 16.8 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger DUF2029 PF09594.5 EFE39186.1 - 0.047 13.1 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2029) BLIP PF07467.6 EFE39186.1 - 0.078 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase inhibitor (BLIP) zf-RING_UBOX PF13445.1 EFE39186.1 - 0.13 12.0 0.9 0.26 11.0 0.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Raptor_N PF14538.1 EFE39189.1 - 7.2e-65 217.5 0.0 1.2e-64 216.7 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.27 EFE39189.1 - 3.6e-07 29.8 0.9 0.32 10.9 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat HEAT PF02985.17 EFE39189.1 - 8.7e-05 22.2 0.8 0.074 13.1 0.0 3.5 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.1 EFE39189.1 - 0.001 19.2 0.0 0.0031 17.7 0.0 1.8 1 0 0 1 1 1 1 HEAT repeats Peptidase_C14 PF00656.17 EFE39189.1 - 0.0014 18.4 0.0 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 Caspase domain Atx10homo_assoc PF09759.4 EFE39189.1 - 0.014 15.0 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain DUF1546 PF07571.8 EFE39189.1 - 0.05 13.7 0.0 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1546) DUF4396 PF14342.1 EFE39190.1 - 2.3e-39 134.6 4.4 7e-39 133.1 3.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4396) Kelch_5 PF13854.1 EFE39191.1 - 1e-33 114.7 3.2 2.5e-06 27.2 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 EFE39191.1 - 2e-26 91.4 22.1 2.9e-07 30.4 0.0 7.0 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.1 EFE39191.1 - 5e-22 77.4 14.2 1.9e-05 24.3 0.1 6.9 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.20 EFE39191.1 - 1.3e-20 72.6 6.9 0.00052 19.5 0.0 7.1 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.1 EFE39191.1 - 4.8e-18 64.4 6.1 3.9e-05 23.6 0.4 6.7 5 1 1 6 6 6 4 Kelch motif Kelch_2 PF07646.10 EFE39191.1 - 2.5e-15 55.5 5.7 0.0033 17.1 0.2 6.8 6 1 0 6 6 6 4 Kelch motif Vac_Fusion PF02346.11 EFE39191.1 - 0.51 9.7 13.0 23 4.5 0.0 5.8 5 1 1 6 6 6 0 Chordopoxvirus fusion protein Pkinase PF00069.20 EFE39192.1 - 4e-38 131.0 0.0 5e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39192.1 - 1.2e-13 50.7 0.0 1.7e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE39192.1 - 3.6e-05 23.6 0.0 0.0023 17.7 0.0 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family bZIP_1 PF00170.16 EFE39194.1 - 7.6e-06 25.7 13.1 1.3e-05 25.0 9.1 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.12 EFE39194.1 - 0.016 15.4 10.7 0.027 14.7 7.4 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor TMF_TATA_bd PF12325.3 EFE39194.1 - 0.017 14.8 3.6 0.033 13.9 2.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF972 PF06156.8 EFE39194.1 - 0.045 14.0 0.2 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_2 PF07716.10 EFE39194.1 - 0.079 12.7 15.6 0.093 12.5 10.1 1.6 1 1 1 2 2 2 0 Basic region leucine zipper Glutaredoxin2_C PF04399.8 EFE39194.1 - 0.091 12.3 1.5 0.16 11.5 1.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GAS PF13851.1 EFE39194.1 - 0.11 11.6 5.7 0.16 11.1 3.9 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding T2SG PF08334.6 EFE39194.1 - 2 8.2 5.6 7.5 6.3 0.5 2.6 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein G Bap31 PF05529.7 EFE39194.1 - 5.4 6.4 5.8 7.5 5.9 4.0 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Phosducin PF02114.11 EFE39195.1 - 1.4e-11 43.5 0.0 1.9e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Phosducin Flagellar_rod PF05149.7 EFE39195.1 - 0.002 17.3 0.5 0.0033 16.6 0.3 1.3 1 0 0 1 1 1 1 Paraflagellar rod protein Adaptin_N PF01602.15 EFE39196.1 - 3.3e-110 368.8 0.5 4.4e-110 368.4 0.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 EFE39196.1 - 2.4e-61 205.9 2.0 5.5e-61 204.8 1.4 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 EFE39196.1 - 9.9e-13 48.1 4.7 2.3e-05 24.5 0.0 5.8 2 2 3 5 5 5 3 HEAT repeats HEAT PF02985.17 EFE39196.1 - 3.1e-05 23.6 4.7 0.47 10.6 0.2 5.8 5 0 0 5 5 5 2 HEAT repeat Alpha_adaptin_C PF02296.11 EFE39196.1 - 0.0011 18.9 0.0 0.0035 17.2 0.0 1.9 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain HEAT_EZ PF13513.1 EFE39196.1 - 0.005 17.2 3.2 0.021 15.2 0.5 3.1 3 0 0 3 3 3 1 HEAT-like repeat HEAT_PBS PF03130.11 EFE39196.1 - 0.033 14.6 5.9 2 9.1 0.1 4.8 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat F-box-like PF12937.2 EFE39197.1 - 1.1e-10 41.0 1.3 2e-10 40.2 0.3 2.0 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.2 EFE39197.1 - 0.016 14.7 0.2 6.1 6.5 0.0 3.7 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) F-box PF00646.28 EFE39197.1 - 0.065 12.9 0.0 0.19 11.4 0.0 1.8 1 0 0 1 1 1 0 F-box domain Hydrolase_like PF13242.1 EFE39198.1 - 4.5e-14 51.9 0.0 3.7e-13 48.9 0.0 2.3 2 1 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 EFE39198.1 - 3.9e-07 29.9 0.0 7.9e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase tRNA-synt_2 PF00152.15 EFE39199.1 - 9e-70 235.0 0.3 1.5e-69 234.3 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFE39199.1 - 1.2e-06 28.3 0.0 2.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Sin_N PF04801.8 EFE39199.1 - 0.087 11.6 4.7 0.13 11.0 3.3 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region SIP1 PF04938.7 EFE39200.1 - 2.8e-05 23.5 0.0 0.0034 16.7 0.0 2.7 2 1 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) SDA1 PF05285.7 EFE39200.1 - 0.52 9.5 12.9 0.74 9.0 9.0 1.2 1 0 0 1 1 1 0 SDA1 PX PF00787.19 EFE39201.1 - 1.1e-16 60.6 0.1 2.6e-16 59.4 0.0 1.7 2 0 0 2 2 2 1 PX domain SNARE PF05739.14 EFE39201.1 - 7.4e-08 31.9 3.4 1.6e-07 30.8 2.4 1.6 1 0 0 1 1 1 1 SNARE domain Ku PF02735.11 EFE39202.1 - 7.8e-18 64.6 0.0 2.4e-17 63.0 0.0 1.8 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.6 EFE39202.1 - 1.4e-14 54.0 1.7 1.5e-14 53.8 0.1 1.9 2 0 0 2 2 2 1 Ku C terminal domain like Ku_N PF03731.10 EFE39202.1 - 2.7e-07 30.2 0.1 5.6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain DUF4149 PF13664.1 EFE39203.1 - 2.2e-17 62.9 0.7 6.3e-17 61.4 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Syntaxin PF00804.20 EFE39204.1 - 0.0074 16.4 1.0 0.0074 16.4 0.7 6.2 5 1 1 6 6 6 3 Syntaxin Baculo_PEP_C PF04513.7 EFE39204.1 - 0.0082 15.9 16.4 4.3 7.1 1.2 5.9 1 1 5 6 6 6 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF730 PF05325.6 EFE39204.1 - 0.24 11.2 0.1 0.24 11.2 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF730) ROS_MUCR PF05443.6 EFE39204.1 - 1.3 8.7 10.5 0.11 12.3 1.0 3.7 3 1 1 4 4 4 0 ROS/MUCR transcriptional regulator protein FlxA PF14282.1 EFE39204.1 - 1.4 8.8 28.0 0.77 9.7 3.2 6.1 3 2 1 5 5 5 0 FlxA-like protein Topoisom_bac PF01131.15 EFE39205.1 - 3e-73 246.9 0.0 3e-72 243.6 0.0 2.0 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 EFE39205.1 - 1.3e-13 50.7 0.0 2.9e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Toprim domain DUF1295 PF06966.7 EFE39206.1 - 2e-40 138.5 6.7 3.2e-40 137.9 4.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF4181 PF13789.1 EFE39206.1 - 0.026 14.4 0.4 0.026 14.4 0.3 2.9 3 2 0 3 3 3 0 Domain of unknown function (DUF4181) ICMT PF04140.9 EFE39206.1 - 0.16 12.1 2.0 0.22 11.7 0.0 2.3 2 1 1 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Peptidase_M41 PF01434.13 EFE39207.1 - 1.1e-74 250.5 0.0 1.1e-74 250.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.24 EFE39207.1 - 7.2e-42 142.7 0.0 2.1e-41 141.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 EFE39207.1 - 2e-08 34.3 0.0 2e-08 34.3 0.0 2.4 3 0 0 3 3 3 1 FtsH Extracellular AAA_22 PF13401.1 EFE39207.1 - 0.00052 20.1 0.5 0.23 11.6 0.0 3.6 4 0 0 4 4 4 1 AAA domain AAA_5 PF07728.9 EFE39207.1 - 0.0018 18.0 0.1 0.0086 15.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 EFE39207.1 - 0.0038 16.6 0.2 0.032 13.6 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE39207.1 - 0.0038 16.9 0.3 0.013 15.2 0.2 1.9 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 EFE39207.1 - 0.012 15.0 0.0 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.8 EFE39207.1 - 0.017 13.8 0.1 0.034 12.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus Pex14_N PF04695.8 EFE39207.1 - 0.022 14.7 0.7 0.022 14.7 0.5 2.7 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RuvB_N PF05496.7 EFE39207.1 - 0.025 13.6 0.0 0.057 12.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EFE39207.1 - 0.029 14.3 2.1 0.11 12.5 0.1 2.7 2 1 1 3 3 3 0 AAA ATPase domain AAA_17 PF13207.1 EFE39207.1 - 0.039 14.7 0.0 0.18 12.6 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFE39207.1 - 0.089 12.6 0.0 0.25 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain Fungal_trans PF04082.13 EFE39208.1 - 1.1e-24 86.7 0.9 1.1e-23 83.3 0.0 2.7 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE39208.1 - 1.8e-09 37.3 13.3 1.8e-09 37.3 9.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF605 PF04652.11 EFE39208.1 - 0.35 10.2 25.4 0.94 8.8 10.3 2.3 2 0 0 2 2 2 0 Vta1 like MCPVI PF02993.9 EFE39208.1 - 0.71 9.9 15.8 0.065 13.3 6.3 2.1 2 0 0 2 2 2 0 Minor capsid protein VI Ctr PF04145.10 EFE39208.1 - 1.3 9.1 6.3 0.25 11.3 1.2 2.2 2 0 0 2 2 2 0 Ctr copper transporter family TFIIA PF03153.8 EFE39208.1 - 5.8 6.6 26.0 5 6.9 11.9 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit APH PF01636.18 EFE39209.1 - 1.3e-07 31.5 0.0 8e-07 29.0 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family tRNA-synt_2b PF00587.20 EFE39210.1 - 5.2e-43 146.6 0.1 8.4e-43 145.9 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFE39210.1 - 2.5e-16 59.3 0.1 4.9e-16 58.4 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 EFE39210.1 - 5.9e-13 48.4 0.0 1.1e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 EFE39210.1 - 0.0025 17.5 0.0 0.0069 16.1 0.0 1.7 1 0 0 1 1 1 1 TGS domain Gar1 PF04410.9 EFE39211.1 - 3.6e-41 140.2 2.4 4.2e-41 139.9 0.0 1.8 1 1 1 2 2 2 1 Gar1/Naf1 RNA binding region CDP-OH_P_transf PF01066.16 EFE39212.1 - 3.3e-12 46.5 0.7 6.8e-12 45.5 0.5 1.5 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase WSC PF01822.14 EFE39213.1 - 3.4e-09 36.5 8.6 6.7e-09 35.5 6.0 1.5 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.5 EFE39213.1 - 6.9e-08 31.6 0.9 1.6e-07 30.5 0.6 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF1049 PF06305.6 EFE39213.1 - 0.032 13.6 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) DUF4366 PF14283.1 EFE39213.1 - 0.041 13.2 0.0 0.058 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Rb_C PF08934.5 EFE39214.1 - 0.0011 18.6 0.5 0.0025 17.4 0.4 1.6 1 0 0 1 1 1 1 Rb C-terminal domain DUF2370 PF10176.4 EFE39215.1 - 3.9e-84 281.6 0.0 8.9e-84 280.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) MLANA PF14991.1 EFE39215.1 - 0.014 15.3 0.1 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 Protein melan-A DUF202 PF02656.10 EFE39215.1 - 0.061 13.5 0.0 0.26 11.5 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF202) CoA_trans PF01144.18 EFE39216.1 - 3.2e-104 346.8 1.7 4.2e-64 215.6 0.2 2.0 2 0 0 2 2 2 2 Coenzyme A transferase MFS_1 PF07690.11 EFE39217.1 - 1.1e-19 70.3 57.9 1.6e-17 63.2 22.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UCH PF00443.24 EFE39218.1 - 3.5e-48 164.0 0.0 6.4e-48 163.1 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 EFE39218.1 - 2.9e-43 145.1 3.6 4.9e-21 73.9 0.1 3.9 3 0 0 3 3 3 3 A repeated domain in UCH-protein UCH_1 PF13423.1 EFE39218.1 - 3.9e-12 46.2 0.0 4.4e-07 29.6 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase AAA_14 PF13173.1 EFE39218.1 - 0.018 14.9 0.3 0.24 11.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain PUB PF09409.5 EFE39219.1 - 0.00062 19.4 0.1 0.0011 18.6 0.1 1.4 1 0 0 1 1 1 1 PUB domain E7 PF00527.13 EFE39219.1 - 0.19 11.8 3.6 0.18 11.9 0.3 2.3 1 1 1 2 2 2 0 E7 protein, Early protein Tim17 PF02466.14 EFE39220.1 - 8.3e-14 51.7 4.7 1.2e-13 51.2 3.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family PH PF00169.24 EFE39221.1 - 4.3e-09 36.5 0.0 1.1e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 PH domain Prominin PF05478.6 EFE39221.1 - 0.15 9.6 0.2 0.21 9.0 0.1 1.1 1 0 0 1 1 1 0 Prominin CHAD PF05235.9 EFE39221.1 - 0.19 11.2 0.1 0.19 11.2 0.0 3.0 2 1 2 4 4 4 0 CHAD domain RRM_1 PF00076.17 EFE39222.1 - 1.8e-30 104.3 0.0 5.3e-18 64.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE39222.1 - 7.6e-25 86.6 0.0 1.7e-15 56.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39222.1 - 1.8e-16 59.6 0.0 8.9e-08 31.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFE39222.1 - 0.0072 16.1 0.0 0.83 9.5 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif ATP-grasp_2 PF08442.5 EFE39222.1 - 0.14 11.5 0.0 0.14 11.5 0.0 2.4 3 0 0 3 3 3 0 ATP-grasp domain FmdA_AmdA PF03069.10 EFE39223.1 - 1.6e-57 194.9 0.0 2.5e-31 108.7 0.0 2.0 1 1 1 2 2 2 2 Acetamidase/Formamidase family AA_permease_2 PF13520.1 EFE39224.1 - 1.2e-51 175.6 45.7 1.6e-51 175.2 31.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE39224.1 - 1.8e-22 79.3 41.7 2.3e-22 78.9 28.9 1.1 1 0 0 1 1 1 1 Amino acid permease COQ9 PF08511.6 EFE39225.1 - 4.5e-24 83.7 0.9 9.5e-24 82.7 0.1 1.9 2 0 0 2 2 2 1 COQ9 PRP3 PF08572.5 EFE39226.1 - 0.074 12.4 0.4 0.12 11.7 0.3 1.2 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) WD40 PF00400.27 EFE39227.1 - 1.1e-12 47.3 0.4 0.0005 19.8 0.0 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat DNA_methylase PF00145.12 EFE39228.1 - 5.7e-33 114.4 0.0 1e-32 113.6 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.13 EFE39228.1 - 1.8e-08 34.1 0.1 4.5e-05 23.1 0.0 2.7 2 0 0 2 2 2 2 BAH domain RasGAP PF00616.14 EFE39229.1 - 7.1e-39 133.5 0.0 3.5e-38 131.2 0.0 2.1 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.25 EFE39229.1 - 2.6e-07 30.4 0.2 6.4e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 C2 domain Methyltransf_2 PF00891.13 EFE39231.1 - 1.3e-29 103.1 0.0 7.5e-29 100.6 0.0 2.1 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 EFE39231.1 - 0.002 18.6 0.0 0.014 15.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Rrf2 PF02082.15 EFE39231.1 - 0.098 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator Methyltransf_12 PF08242.7 EFE39231.1 - 0.14 12.6 0.1 1.8 9.1 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase domain GFO_IDH_MocA PF01408.17 EFE39232.1 - 2.7e-16 60.1 0.0 4.3e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EFE39232.1 - 0.00012 21.7 0.0 0.0011 18.6 0.0 2.4 2 1 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain ADSL_C PF10397.4 EFE39232.1 - 0.0011 18.9 0.2 0.74 9.8 0.0 2.3 2 0 0 2 2 2 2 Adenylosuccinate lyase C-terminus NAD_binding_3 PF03447.11 EFE39232.1 - 0.044 14.1 0.1 0.11 12.8 0.1 1.7 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain CoA_binding_2 PF13380.1 EFE39232.1 - 0.058 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 CoA binding domain Transp_cyt_pur PF02133.10 EFE39233.1 - 4.8e-86 289.0 29.7 5.8e-86 288.7 20.6 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin AMP-binding PF00501.23 EFE39234.1 - 6.1e-64 215.9 0.1 3e-44 151.0 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 EFE39234.1 - 8.5e-27 93.7 0.0 3.8e-26 91.6 0.0 1.8 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.20 EFE39234.1 - 2.8e-07 30.6 0.1 7.8e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site WES_acyltransf PF03007.11 EFE39234.1 - 0.12 11.9 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain AATase PF07247.7 EFE39234.1 - 0.22 10.0 0.0 0.33 9.4 0.0 1.1 1 0 0 1 1 1 0 Alcohol acetyltransferase HxxPF_rpt PF13745.1 EFE39235.1 - 6.8e-09 35.9 0.0 1.1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 HxxPF-repeated domain Condensation PF00668.15 EFE39235.1 - 0.0027 16.6 0.0 0.013 14.3 0.0 1.9 2 0 0 2 2 2 1 Condensation domain Peptidase_M19 PF01244.16 EFE39236.1 - 5.4e-103 344.2 0.0 6.3e-103 344.0 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) p450 PF00067.17 EFE39237.1 - 1.8e-43 148.7 0.0 2.3e-42 145.0 0.0 1.9 2 0 0 2 2 2 2 Cytochrome P450 GST_C PF00043.20 EFE39238.1 - 7.5e-07 29.0 0.0 1.2e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EFE39238.1 - 0.0001 22.2 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE39238.1 - 0.00016 21.5 0.1 0.00031 20.5 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFE39238.1 - 0.0002 21.5 0.0 0.00043 20.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 EFE39238.1 - 0.00057 20.3 0.1 0.00081 19.8 0.1 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFE39238.1 - 0.0028 17.8 0.0 0.0056 16.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Methyltransf_2 PF00891.13 EFE39239.1 - 3.1e-37 128.0 0.0 4.7e-37 127.4 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 EFE39239.1 - 5.5e-05 22.9 0.1 0.00036 20.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Dimerisation PF08100.6 EFE39239.1 - 0.00011 21.9 0.2 0.0004 20.1 0.1 2.0 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_12 PF08242.7 EFE39239.1 - 0.014 15.8 0.0 0.043 14.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Rrf2 PF02082.15 EFE39239.1 - 0.059 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator Methyltransf_18 PF12847.2 EFE39239.1 - 0.061 13.9 0.0 0.35 11.4 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Pyr_redox_2 PF07992.9 EFE39240.1 - 2.1e-14 53.8 0.0 3e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFE39240.1 - 5e-05 22.3 0.2 0.00019 20.4 0.1 1.9 2 1 1 3 3 3 1 Glucose inhibited division protein A DAO PF01266.19 EFE39240.1 - 0.00011 21.2 0.0 0.00021 20.3 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 EFE39240.1 - 0.00013 20.7 0.0 0.00063 18.4 0.0 1.9 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.1 EFE39240.1 - 0.00021 21.2 0.4 0.00074 19.4 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFE39240.1 - 0.00021 21.0 0.0 1.4 8.6 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding HI0933_like PF03486.9 EFE39240.1 - 0.0005 18.6 0.0 0.0021 16.6 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.19 EFE39240.1 - 0.0011 17.8 0.1 0.0024 16.7 0.0 1.6 2 1 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.14 EFE39240.1 - 0.012 14.7 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.7 EFE39240.1 - 0.015 14.1 0.0 0.082 11.8 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.12 EFE39240.1 - 0.026 13.6 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.16 EFE39240.1 - 0.069 12.7 0.0 0.29 10.6 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 EFE39240.1 - 0.086 13.2 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE39243.1 - 1e-18 67.9 0.0 1.4e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFE39243.1 - 0.00043 20.1 0.5 0.2 11.4 0.2 3.4 2 2 2 4 4 4 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 EFE39243.1 - 0.00076 18.4 0.2 0.0022 16.9 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.19 EFE39243.1 - 0.00092 18.2 0.5 0.0016 17.4 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE39243.1 - 0.0013 18.7 0.4 0.0026 17.7 0.3 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFE39243.1 - 0.0078 16.2 0.3 0.98 9.4 0.2 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFE39243.1 - 0.032 13.0 0.0 0.068 12.0 0.0 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.9 EFE39243.1 - 0.035 12.5 0.2 0.11 10.9 0.1 1.8 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.14 EFE39243.1 - 0.037 13.0 0.5 0.097 11.6 0.2 1.8 2 0 0 2 2 2 0 FAD binding domain p450 PF00067.17 EFE39244.1 - 6.1e-34 117.3 0.0 8.6e-34 116.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_1_2 PF00155.16 EFE39245.1 - 1.6e-36 126.0 0.0 2.1e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II MBOAT_2 PF13813.1 EFE39245.1 - 2.1e-15 56.5 0.4 4.6e-15 55.4 0.3 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family ABC_tran PF00005.22 EFE39246.1 - 3e-32 111.7 0.0 5.8e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EFE39246.1 - 2.7e-09 36.8 21.8 3.3e-08 33.2 6.8 2.3 1 1 1 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 EFE39246.1 - 2.2e-07 30.3 0.1 0.0004 19.6 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE39246.1 - 3.7e-07 30.4 0.0 0.0006 19.8 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_29 PF13555.1 EFE39246.1 - 0.0004 19.8 0.2 0.001 18.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE39246.1 - 0.00086 19.3 0.2 0.0023 17.9 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_10 PF12846.2 EFE39246.1 - 0.001 18.5 0.3 0.0075 15.7 0.1 2.3 2 0 0 2 2 2 1 AAA-like domain AAA_22 PF13401.1 EFE39246.1 - 0.0011 19.0 0.1 0.0063 16.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 EFE39246.1 - 0.003 17.4 0.3 0.066 13.1 0.2 2.6 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.1 EFE39246.1 - 0.0049 15.9 0.0 0.13 11.3 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.1 EFE39246.1 - 0.007 16.7 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFE39246.1 - 0.0094 15.1 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 EFE39246.1 - 0.044 13.1 0.0 0.094 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFE39246.1 - 0.061 14.1 0.0 0.14 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 EFE39246.1 - 0.065 13.0 0.8 0.12 12.1 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_18 PF13238.1 EFE39246.1 - 0.091 13.0 0.0 0.25 11.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain MFS_1 PF07690.11 EFE39247.1 - 1.7e-44 151.9 46.9 1.7e-44 151.9 32.5 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE39247.1 - 4.8e-19 68.0 14.8 9.7e-19 66.9 10.2 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE39247.1 - 3.1e-13 49.1 11.1 3.1e-13 49.1 7.7 3.1 1 1 2 3 3 3 1 Sugar (and other) transporter DUF1422 PF07226.6 EFE39247.1 - 0.0032 17.1 0.4 0.0032 17.1 0.3 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1422) AIG2_2 PF13772.1 EFE39248.1 - 0.068 13.2 0.0 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 AIG2-like family GIT1_C PF12205.3 EFE39249.1 - 0.065 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term KGG PF10685.4 EFE39249.1 - 0.073 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Stress-induced bacterial acidophilic repeat motif p450 PF00067.17 EFE39250.1 - 1.2e-57 195.5 0.0 2.5e-57 194.4 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 EFE39251.1 - 1.6e-18 66.5 0.0 2.2e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Trp_halogenase PF04820.9 EFE39252.1 - 1.2e-12 47.2 0.4 5.2e-12 45.1 0.2 1.9 1 1 0 1 1 1 1 Tryptophan halogenase UNC45-central PF11701.3 EFE39253.1 - 1.2e-42 145.2 1.8 9.9e-39 132.4 0.2 3.7 3 0 0 3 3 3 2 Myosin-binding striated muscle assembly central Atx10homo_assoc PF09759.4 EFE39253.1 - 0.0037 16.9 0.0 1 9.1 0.0 3.0 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.18 EFE39253.1 - 0.0077 16.0 9.6 15 5.5 0.0 6.9 8 0 0 8 8 8 1 Armadillo/beta-catenin-like repeat PUL PF08324.6 EFE39253.1 - 0.011 14.5 0.1 0.096 11.4 0.1 2.4 3 0 0 3 3 3 0 PUL domain FANCI_HD1 PF14679.1 EFE39253.1 - 0.065 12.9 0.3 15 5.4 0.0 3.4 3 0 0 3 3 3 0 FANCI helical domain 1 Peptidase_S9 PF00326.16 EFE39253.1 - 0.1 11.8 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF4286 PF14114.1 EFE39253.1 - 0.19 12.0 0.0 0.47 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) Tfb4 PF03850.9 EFE39254.1 - 3.4e-110 367.6 0.0 4.4e-110 367.2 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 zf-C2HC5 PF06221.8 EFE39254.1 - 0.39 10.5 5.2 0.74 9.6 3.6 1.4 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type DUF1180 PF06679.7 EFE39254.1 - 3.9 7.3 8.2 7.1 6.4 2.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Asparaginase_2 PF01112.13 EFE39255.1 - 4.4e-37 127.4 4.6 6.5e-23 80.9 0.0 2.2 2 0 0 2 2 2 2 Asparaginase Actin PF00022.14 EFE39257.1 - 7.9e-84 281.3 0.0 1.3e-83 280.6 0.0 1.3 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EFE39257.1 - 0.00011 20.9 0.1 0.0037 15.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein tRNA_U5-meth_tr PF05958.6 EFE39258.1 - 2.8e-16 59.1 0.1 3e-14 52.4 0.0 2.7 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 EFE39258.1 - 1.2e-06 28.1 0.0 2.5e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TRAM PF01938.15 EFE39258.1 - 2.6e-05 23.8 0.0 8.8e-05 22.2 0.0 1.8 1 0 0 1 1 1 1 TRAM domain Methyltransf_15 PF09445.5 EFE39258.1 - 0.00016 21.2 0.0 0.0003 20.3 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.2 EFE39258.1 - 0.0006 20.3 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE39258.1 - 0.0022 18.4 0.1 0.028 14.9 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE39258.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EFE39258.1 - 0.026 13.6 0.0 0.056 12.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EFE39258.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ribosomal_S5_C PF03719.10 EFE39260.1 - 1.7e-15 56.0 0.0 5.2e-15 54.4 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 EFE39260.1 - 1.6e-12 46.9 0.2 4.2e-12 45.6 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain ISN1 PF06437.6 EFE39260.1 - 0.03 13.0 0.1 0.1 11.2 0.0 1.8 2 0 0 2 2 2 0 IMP-specific 5'-nucleotidase DASH_Dad3 PF08656.5 EFE39261.1 - 3.8e-27 93.7 1.4 4.4e-27 93.5 1.0 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 Peptidase_M75 PF09375.5 EFE39261.1 - 0.035 13.4 0.2 0.036 13.3 0.1 1.1 1 0 0 1 1 1 0 Imelysin RINT1_TIP1 PF04437.8 EFE39261.1 - 0.057 11.9 0.6 0.07 11.6 0.4 1.0 1 0 0 1 1 1 0 RINT-1 / TIP-1 family Pkinase PF00069.20 EFE39263.1 - 1.1e-62 211.4 0.0 3.3e-35 121.5 0.1 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39263.1 - 1e-24 87.0 0.0 2.1e-15 56.4 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 EFE39263.1 - 0.025 13.5 0.0 0.64 8.9 0.0 2.3 2 0 0 2 2 2 0 Kinase-like DUF4267 PF14087.1 EFE39264.1 - 2e-28 98.2 4.3 2.3e-28 98.0 2.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) DUF998 PF06197.8 EFE39264.1 - 0.036 13.3 12.2 0.1 11.9 8.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF998) MFS_1 PF07690.11 EFE39265.1 - 1.3e-29 102.9 54.3 4.9e-26 91.2 38.7 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily UEV PF05743.8 EFE39265.1 - 0.034 13.8 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 UEV domain TRF PF08558.5 EFE39268.1 - 8.3e-80 267.5 0.4 1.5e-79 266.7 0.3 1.4 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 EFE39268.1 - 1.6e-05 24.8 0.0 3.2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4578 PF15147.1 EFE39268.1 - 0.083 13.2 4.9 0.12 12.7 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) Myb_DNA-bind_6 PF13921.1 EFE39268.1 - 0.092 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Zip PF02535.17 EFE39268.1 - 0.13 11.2 4.1 0.29 10.0 2.8 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter TFIID_30kDa PF03540.8 EFE39269.1 - 2.4e-23 81.6 0.1 4e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit FoP_duplication PF13865.1 EFE39269.1 - 0.27 11.7 1.4 0.91 10.0 1.0 2.0 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 IPK PF03770.11 EFE39270.1 - 2.7e-60 203.4 0.0 3.3e-60 203.1 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase EBV-NA3 PF05009.7 EFE39270.1 - 0.18 11.0 1.2 4 6.6 1.3 2.1 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Arb1 PF09692.5 EFE39271.1 - 6.6e-143 476.3 0.1 8e-143 476.0 0.1 1.1 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 ADH_zinc_N PF00107.21 EFE39272.1 - 1.5e-29 102.1 0.0 2.4e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFE39272.1 - 5.7e-16 59.5 0.0 1.1e-15 58.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE39272.1 - 1.7e-08 34.1 0.0 3.3e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF3425 PF11905.3 EFE39273.1 - 6.6e-23 81.0 0.0 1.3e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.16 EFE39273.1 - 0.0038 17.1 10.1 0.0066 16.3 7.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor Abhydrolase_6 PF12697.2 EFE39274.1 - 1e-22 81.1 0.0 1.5e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE39274.1 - 1.4e-08 34.6 0.0 2e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE39274.1 - 3.7e-07 30.0 0.0 9.9e-07 28.6 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EFE39274.1 - 0.018 14.8 0.0 0.085 12.7 0.0 2.1 2 0 0 2 2 2 0 Putative lysophospholipase DUF1989 PF09347.5 EFE39275.1 - 1.2e-55 187.5 0.1 1.4e-55 187.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Aminotran_1_2 PF00155.16 EFE39277.1 - 2.1e-37 128.9 0.0 2.7e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF663 PF04950.7 EFE39278.1 - 2e-92 309.3 0.0 2e-92 309.3 0.0 2.3 2 1 0 2 2 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 EFE39278.1 - 1.3e-26 91.8 0.0 2.9e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 EFE39278.1 - 1.9e-07 30.7 0.0 5.2e-05 22.7 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 EFE39278.1 - 5.8e-05 23.2 0.0 0.00016 21.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE39278.1 - 5.9e-05 23.1 0.1 0.00024 21.1 0.0 2.1 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.24 EFE39278.1 - 9.2e-05 22.6 0.0 0.00023 21.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE39278.1 - 0.00026 21.8 0.0 0.00026 21.8 0.0 4.2 4 1 1 5 5 2 1 AAA domain MobB PF03205.9 EFE39278.1 - 0.00027 20.6 0.2 0.00062 19.4 0.1 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 EFE39278.1 - 0.00031 20.6 0.0 0.00087 19.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE39278.1 - 0.0018 18.7 0.0 0.0061 17.0 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein AAA_18 PF13238.1 EFE39278.1 - 0.0022 18.2 0.9 0.014 15.6 0.0 3.0 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 EFE39278.1 - 0.0028 17.5 0.0 0.012 15.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 EFE39278.1 - 0.0035 16.8 0.0 0.031 13.7 0.0 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 EFE39278.1 - 0.0043 16.6 0.1 0.0097 15.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EFE39278.1 - 0.0044 17.3 1.5 0.0084 16.4 0.0 2.2 2 0 0 2 2 1 1 ABC transporter NACHT PF05729.7 EFE39278.1 - 0.0049 16.5 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NTPase_1 PF03266.10 EFE39278.1 - 0.006 16.3 0.4 0.012 15.3 0.2 1.4 1 0 0 1 1 1 1 NTPase NB-ARC PF00931.17 EFE39278.1 - 0.0061 15.4 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain RNA_helicase PF00910.17 EFE39278.1 - 0.009 16.1 0.0 0.023 14.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.1 EFE39278.1 - 0.0094 15.8 0.1 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.14 EFE39278.1 - 0.014 14.8 0.2 0.028 13.8 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.1 EFE39278.1 - 0.023 14.4 0.7 0.045 13.5 0.1 1.8 2 0 0 2 2 1 0 Part of AAA domain AAA_25 PF13481.1 EFE39278.1 - 0.027 13.8 0.0 0.091 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 EFE39278.1 - 0.029 13.5 0.0 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SRPRB PF09439.5 EFE39278.1 - 0.034 13.3 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.9 EFE39278.1 - 0.055 13.1 0.1 0.19 11.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_11 PF13086.1 EFE39278.1 - 0.06 12.9 2.9 0.63 9.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EFE39278.1 - 0.11 12.0 0.1 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATP_bind_1 PF03029.12 EFE39278.1 - 0.15 11.5 0.1 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein FeoB_N PF02421.13 EFE39278.1 - 0.23 10.7 0.0 0.69 9.1 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B GerE PF00196.14 EFE39279.1 - 1 8.7 3.7 1 8.7 2.6 1.1 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Na_H_Exchanger PF00999.16 EFE39281.1 - 7.5e-44 149.7 19.8 9.8e-44 149.3 13.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PhaG_MnhG_YufB PF03334.9 EFE39281.1 - 2.4 8.2 13.6 2 8.5 0.2 4.0 3 1 0 3 3 3 0 Na+/H+ antiporter subunit GFO_IDH_MocA PF01408.17 EFE39282.1 - 1.8e-18 67.2 0.0 2.8e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_23 PF13489.1 EFE39283.1 - 2.6e-07 30.4 0.1 8.8e-07 28.7 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain PPR_3 PF13812.1 EFE39283.1 - 0.057 13.7 0.0 2.1 8.8 0.0 2.5 2 0 0 2 2 2 0 Pentatricopeptide repeat domain UPF0146 PF03686.8 EFE39283.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) ERG4_ERG24 PF01222.12 EFE39284.1 - 1.4e-138 462.0 20.3 1.7e-138 461.8 14.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family YjgP_YjgQ PF03739.9 EFE39285.1 - 0.66 8.6 8.3 0.77 8.4 5.8 1.0 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family zf-C3HC4_2 PF13923.1 EFE39286.1 - 6.4e-06 26.1 11.4 1.1e-05 25.3 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE39286.1 - 9.3e-06 25.2 9.4 1.8e-05 24.3 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE39286.1 - 7.6e-05 22.4 11.2 0.00016 21.4 7.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFE39286.1 - 0.00021 20.8 7.9 0.00035 20.1 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE39286.1 - 0.00046 19.8 7.2 0.00097 18.8 5.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EFE39286.1 - 0.00049 19.9 9.1 0.0025 17.6 6.5 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFE39286.1 - 0.44 10.2 9.1 1.1 9.0 6.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger UCH PF00443.24 EFE39287.1 - 3.8e-41 140.9 0.0 1.4e-40 139.1 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE39287.1 - 3.4e-19 69.4 0.0 7.3e-18 65.0 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DLH PF01738.13 EFE39288.1 - 3.5e-25 88.5 0.0 4.4e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EFE39288.1 - 5.2e-06 26.2 0.0 7.4e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.6 EFE39288.1 - 0.0034 17.1 0.0 0.096 12.3 0.0 2.1 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.13 EFE39288.1 - 0.015 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Chs3p PF12271.3 EFE39289.1 - 1.4e-71 240.8 14.0 1.7e-71 240.6 9.7 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit MpPF26 PF07666.6 EFE39289.1 - 0.0097 15.8 3.5 0.0097 15.8 2.4 3.0 2 2 1 3 3 3 1 M penetrans paralogue family 26 Glyoxalase_2 PF12681.2 EFE39290.1 - 5.5e-09 36.6 0.1 2.2e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase PF00903.20 EFE39290.1 - 3.4e-05 23.8 0.1 0.00011 22.1 0.1 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily dCMP_cyt_deam_1 PF00383.17 EFE39293.1 - 0.00011 21.7 0.0 0.00069 19.2 0.0 2.2 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Cyclin PF08613.6 EFE39294.1 - 2.3e-27 96.2 1.5 2.3e-27 96.2 1.1 2.7 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 EFE39294.1 - 0.00033 20.2 0.0 0.00033 20.2 0.0 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain DUF4407 PF14362.1 EFE39294.1 - 0.45 9.4 16.2 4.4 6.1 7.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Arm PF00514.18 EFE39295.1 - 1.8e-14 52.9 11.7 0.0012 18.5 0.3 8.3 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EFE39295.1 - 5e-06 26.6 5.1 0.26 11.6 0.0 5.9 6 1 0 6 6 6 2 HEAT repeats Ric8 PF10165.4 EFE39295.1 - 0.0087 14.9 0.4 0.093 11.5 0.0 2.8 4 0 0 4 4 4 1 Guanine nucleotide exchange factor synembryn HEAT PF02985.17 EFE39295.1 - 0.011 15.7 14.6 1.2 9.4 0.1 6.7 7 0 0 7 7 7 0 HEAT repeat Fructosamin_kin PF03881.9 EFE39296.1 - 1.4e-63 214.5 0.0 6e-63 212.5 0.0 1.8 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.18 EFE39296.1 - 4.3e-06 26.6 0.0 8.2e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE39296.1 - 0.18 10.3 0.0 0.88 8.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) GST_N_3 PF13417.1 EFE39297.1 - 9.2e-23 80.2 0.1 2.2e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE39297.1 - 3.5e-14 52.5 0.0 7.3e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFE39297.1 - 0.0023 18.0 0.0 0.0098 16.0 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE39297.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-C2H2 PF00096.21 EFE39298.1 - 3.3e-06 27.0 43.6 0.00073 19.7 0.4 8.3 7 1 1 8 8 8 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE39298.1 - 0.00023 21.2 44.6 0.017 15.4 0.4 8.0 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE39298.1 - 0.00075 19.5 46.5 0.038 14.1 0.4 7.9 6 2 2 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFE39298.1 - 0.013 15.3 1.6 0.013 15.3 1.1 6.3 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EFE39298.1 - 0.042 13.9 40.0 3.1 7.9 7.2 4.3 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 EFE39298.1 - 0.078 13.2 30.6 0.9 9.8 0.3 6.6 7 0 0 7 7 7 0 Zinc-finger of C2H2 type Cyclin_N PF00134.18 EFE39299.1 - 0.0005 19.6 0.2 0.053 13.0 0.0 2.8 2 1 0 2 2 2 2 Cyclin, N-terminal domain CTP_transf_1 PF01148.15 EFE39300.1 - 1.5e-81 273.8 26.5 1.5e-81 273.8 18.4 2.1 2 0 0 2 2 2 2 Cytidylyltransferase family DUF3636 PF12331.3 EFE39301.1 - 1.8e-54 183.3 0.1 4.6e-54 182.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) DUF4164 PF13747.1 EFE39301.1 - 0.012 15.6 0.7 0.012 15.6 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) DUF1192 PF06698.6 EFE39301.1 - 0.15 11.8 6.6 0.45 10.3 4.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) FA_desaturase PF00487.19 EFE39303.1 - 1e-09 38.2 18.9 1e-09 38.2 13.1 2.0 1 1 1 2 2 2 1 Fatty acid desaturase GDPD PF03009.12 EFE39304.1 - 2.4e-18 66.6 0.0 3.1e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family adh_short PF00106.20 EFE39305.1 - 1.2e-13 51.3 0.0 1.7e-11 44.3 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFE39305.1 - 1.7e-05 24.5 0.0 4.2e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE39305.1 - 6.4e-05 22.4 0.1 0.29 10.5 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFE39305.1 - 0.00017 20.5 0.1 0.00082 18.3 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.1 EFE39305.1 - 0.033 14.2 0.1 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 NADH(P)-binding Polysacc_synt_2 PF02719.10 EFE39305.1 - 0.044 12.6 0.0 0.33 9.7 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein MFS_1 PF07690.11 EFE39306.1 - 7.5e-20 70.9 28.4 7.5e-20 70.9 19.7 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Prominin PF05478.6 EFE39306.1 - 0.13 9.7 0.4 0.18 9.2 0.2 1.2 1 0 0 1 1 1 0 Prominin PDGLE PF13190.1 EFE39306.1 - 0.2 11.3 0.0 0.2 11.3 0.0 2.6 3 0 0 3 3 3 0 PDGLE domain Methyltransf_26 PF13659.1 EFE39308.1 - 1.8e-11 44.0 0.0 2.4e-10 40.4 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE39308.1 - 7.9e-09 35.2 0.0 1.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE39308.1 - 5.4e-08 33.4 0.0 2.2e-07 31.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EFE39308.1 - 3.4e-05 23.3 0.0 0.00086 18.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EFE39308.1 - 4.8e-05 23.6 0.0 9.5e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_10 PF05971.7 EFE39308.1 - 0.00033 19.8 0.0 0.00078 18.6 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF890) Ubie_methyltran PF01209.13 EFE39308.1 - 0.0036 16.4 0.0 0.0052 15.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.8 EFE39308.1 - 0.0036 16.4 0.0 0.0059 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) N6_Mtase PF02384.11 EFE39308.1 - 0.0059 15.7 0.0 0.022 13.8 0.0 1.8 1 1 0 1 1 1 1 N-6 DNA Methylase UPF0020 PF01170.13 EFE39308.1 - 0.015 14.8 0.0 0.29 10.7 0.1 2.5 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 AviRa PF11599.3 EFE39308.1 - 0.028 13.4 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_32 PF13679.1 EFE39308.1 - 0.05 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 EFE39308.1 - 0.12 12.8 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Epimerase_Csub PF13950.1 EFE39308.1 - 2.2 8.2 6.8 1.8 8.5 0.8 2.9 3 0 0 3 3 3 0 UDP-glucose 4-epimerase C-term subunit Asp PF00026.18 EFE39309.1 - 1.5e-66 224.8 0.2 1.9e-66 224.4 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFE39309.1 - 8.5e-10 38.8 0.5 2.4e-08 34.0 0.3 2.9 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFE39309.1 - 2.9e-06 27.6 1.7 0.016 15.6 0.2 4.3 3 1 0 3 3 3 1 Aspartyl protease TAXi_C PF14541.1 EFE39309.1 - 0.0063 16.0 0.0 0.012 15.1 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.1 EFE39309.1 - 0.034 13.9 0.1 2.3 8.0 0.0 2.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease SLX9 PF15341.1 EFE39310.1 - 0.011 16.1 0.9 0.017 15.5 0.6 1.1 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Ribosomal_L32p PF01783.18 EFE39310.1 - 0.93 9.7 4.4 4.1 7.6 3.0 2.1 1 1 0 1 1 1 0 Ribosomal L32p protein family TPR_8 PF13181.1 EFE39311.1 - 0.0013 18.3 0.2 3.8 7.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE39311.1 - 0.041 13.5 1.3 2.6 7.7 0.0 3.4 4 0 0 4 4 4 0 TPR repeat TPR_14 PF13428.1 EFE39311.1 - 0.065 13.9 4.7 54 4.8 0.0 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.4 EFE39311.1 - 0.17 11.7 3.3 5.2 7.0 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 EFE39311.1 - 0.42 11.3 3.9 4 8.2 0.8 3.3 2 1 0 2 2 2 0 Sel1 repeat TPR_12 PF13424.1 EFE39311.1 - 0.48 10.4 6.1 14 5.6 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE39311.1 - 3 8.2 7.1 11 6.3 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat PH_10 PF15411.1 EFE39312.1 - 4.4e-23 81.6 0.1 7.2e-23 80.9 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain VWA_3 PF13768.1 EFE39312.1 - 2.3e-08 33.9 0.0 1.4e-07 31.2 0.0 2.3 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 EFE39312.1 - 4.4e-07 29.8 0.0 9.4e-07 28.7 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-RING_2 PF13639.1 EFE39312.1 - 1.5e-06 27.8 5.2 3.4e-06 26.7 3.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EFE39312.1 - 8.2e-05 22.2 3.8 0.00016 21.3 2.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFE39312.1 - 0.00058 19.4 1.7 0.0012 18.4 1.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE39312.1 - 0.0035 17.3 4.8 0.007 16.3 3.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFE39312.1 - 0.015 15.4 1.7 0.035 14.2 1.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4 PF00097.20 EFE39312.1 - 0.051 13.2 5.9 0.044 13.4 3.0 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 EFE39312.1 - 0.24 11.4 4.1 0.49 10.4 2.8 1.5 1 0 0 1 1 1 0 RING-like domain Ribosomal_L12 PF00542.14 EFE39313.1 - 3.8e-20 71.6 8.3 9.7e-19 67.1 3.9 2.2 2 0 0 2 2 2 2 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.14 EFE39313.1 - 0.0029 17.9 6.8 0.0029 17.9 4.7 2.3 1 1 2 3 3 3 1 60s Acidic ribosomal protein DFP PF04127.10 EFE39313.1 - 0.044 13.4 0.5 0.39 10.3 0.0 2.0 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein Cpn60_TCP1 PF00118.19 EFE39314.1 - 5.9e-131 437.4 2.2 7e-131 437.1 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2052 PF09747.4 EFE39314.1 - 0.0075 16.2 0.6 0.0075 16.2 0.4 1.6 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) CENP-B_dimeris PF09026.5 EFE39314.1 - 0.52 10.5 6.7 1.2 9.4 4.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain E1_dh PF00676.15 EFE39315.1 - 1.3e-106 355.7 0.1 1.8e-106 355.2 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 EFE39315.1 - 0.00016 20.6 0.0 0.00035 19.6 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.1 EFE39315.1 - 1.7 9.3 6.4 4.6 7.9 0.3 2.8 2 1 0 2 2 2 0 KRTAP type 7 family PAT1 PF09770.4 EFE39316.1 - 0.88 7.7 23.1 0.97 7.5 16.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Mak10 PF04112.8 EFE39319.1 - 1.1e-40 138.5 0.0 1.7e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase HTH_AsnC-type PF13404.1 EFE39321.1 - 0.0023 17.4 0.0 0.016 14.7 0.0 2.2 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain Sox_N PF12444.3 EFE39321.1 - 4.3 8.4 6.9 1e+02 4.1 0.0 2.8 3 0 0 3 3 3 0 Sox developmental protein N terminal Cpn60_TCP1 PF00118.19 EFE39322.1 - 1.9e-117 392.8 6.3 2.2e-117 392.6 4.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1547 PF07577.6 EFE39322.1 - 0.18 11.4 1.6 0.48 10.1 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1547) Cofilin_ADF PF00241.15 EFE39323.1 - 8.5e-24 83.8 0.0 1e-23 83.5 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein COX4 PF02936.9 EFE39324.1 - 9.3e-42 142.1 3.9 6.5e-25 87.5 0.0 2.1 2 0 0 2 2 2 2 Cytochrome c oxidase subunit IV DUF1289 PF06945.8 EFE39324.1 - 5.3 6.5 5.2 5.8 6.4 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1289) Alpha-amylase_C PF02806.13 EFE39325.1 - 8e-24 83.6 0.1 2.1e-23 82.2 0.0 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 EFE39325.1 - 3e-19 69.5 0.4 1.3e-13 51.0 0.1 3.2 2 1 1 3 3 3 2 Alpha amylase, catalytic domain CBM_48 PF02922.13 EFE39325.1 - 2.6e-14 53.0 0.1 6.1e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) ATP-synt_ab PF00006.20 EFE39326.1 - 8e-62 208.5 0.0 1.3e-61 207.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EFE39326.1 - 1.1e-25 90.2 0.5 2e-25 89.4 0.4 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EFE39326.1 - 4.8e-16 58.7 6.9 7e-14 51.7 0.3 3.0 3 0 0 3 3 3 2 ATP synthase alpha/beta family, beta-barrel domain AAA_25 PF13481.1 EFE39326.1 - 0.0014 18.0 0.1 0.028 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFE39326.1 - 0.011 15.9 0.0 0.62 10.2 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 EFE39326.1 - 0.015 15.0 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase DUF258 PF03193.11 EFE39326.1 - 0.022 13.9 0.1 0.04 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 EFE39326.1 - 0.029 14.0 0.1 0.092 12.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain MobB PF03205.9 EFE39326.1 - 0.031 13.9 0.1 1.7 8.3 0.0 2.8 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B KaiC PF06745.8 EFE39326.1 - 0.034 13.2 0.1 0.059 12.4 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.1 EFE39326.1 - 0.04 13.9 0.2 0.4 10.6 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 EFE39326.1 - 0.086 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.1 EFE39326.1 - 0.087 12.9 0.0 0.46 10.6 0.0 2.2 1 1 0 1 1 1 0 AAA domain FAD_binding_4 PF01565.18 EFE39327.1 - 3.3e-17 62.2 0.3 6.2e-17 61.3 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE39327.1 - 7.2e-10 38.6 0.2 1.7e-09 37.4 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like AAA_2 PF07724.9 EFE39331.1 - 1.4e-38 132.4 0.0 1.9e-37 128.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 EFE39331.1 - 1e-14 54.8 0.0 2.3e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 EFE39331.1 - 1.5e-09 37.6 0.1 5e-09 35.9 0.0 1.9 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 EFE39331.1 - 1.5e-06 27.9 0.0 3.4e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 EFE39331.1 - 0.00015 21.0 0.1 0.0061 15.7 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EFE39331.1 - 0.00028 20.4 0.0 0.085 12.3 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.1 EFE39331.1 - 0.00058 20.0 0.3 0.0082 16.2 0.2 2.3 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EFE39331.1 - 0.00071 19.0 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.1 EFE39331.1 - 0.00083 20.1 0.2 0.0024 18.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 EFE39331.1 - 0.0012 18.8 0.7 0.003 17.5 0.0 1.9 2 1 0 2 2 1 1 AAA ATPase domain AAA_24 PF13479.1 EFE39331.1 - 0.0035 16.9 0.0 0.0065 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EFE39331.1 - 0.0037 16.6 0.0 0.0073 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFE39331.1 - 0.0066 15.5 0.1 0.099 11.6 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EFE39331.1 - 0.015 15.1 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain MCM PF00493.18 EFE39331.1 - 0.023 13.4 0.2 0.08 11.7 0.1 1.8 1 1 0 1 1 1 0 MCM2/3/5 family AAA_33 PF13671.1 EFE39331.1 - 0.032 14.0 2.3 0.38 10.6 0.0 3.0 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.17 EFE39331.1 - 0.046 13.8 0.0 0.093 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 EFE39331.1 - 0.05 13.8 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_3 PF07726.6 EFE39331.1 - 0.055 13.0 0.0 0.14 11.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 EFE39331.1 - 0.086 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 EFE39331.1 - 0.11 12.1 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.1 EFE39331.1 - 0.13 12.6 0.1 0.47 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Chromo PF00385.19 EFE39332.1 - 4.7e-09 35.7 0.1 9.3e-09 34.8 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.1 EFE39332.1 - 0.0095 15.8 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 Ras PF00071.17 EFE39333.1 - 9e-59 197.4 0.1 1.1e-58 197.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE39333.1 - 4.6e-21 75.5 0.2 8.1e-21 74.7 0.1 1.5 2 0 0 2 2 1 1 Miro-like protein Arf PF00025.16 EFE39333.1 - 3.4e-13 49.2 0.1 4.2e-13 48.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFE39333.1 - 6.5e-08 32.5 0.1 1.2e-07 31.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFE39333.1 - 7.1e-06 25.5 0.1 2.4e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 EFE39333.1 - 1.3e-05 25.3 0.1 4.2e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain Gtr1_RagA PF04670.7 EFE39333.1 - 3.1e-05 23.2 0.2 4e-05 22.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_15 PF13175.1 EFE39333.1 - 5.4e-05 22.4 0.0 5.6e-05 22.3 0.0 1.2 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 EFE39333.1 - 0.00012 21.2 0.1 0.00026 20.2 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 EFE39333.1 - 0.00055 19.8 0.1 0.0018 18.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE39333.1 - 0.0017 18.4 1.1 0.0064 16.5 0.8 2.0 1 1 0 1 1 1 1 AAA ATPase domain SpoIIID PF12116.3 EFE39333.1 - 0.0051 16.7 0.2 0.063 13.2 0.0 2.2 2 0 0 2 2 2 1 Stage III sporulation protein D SRPRB PF09439.5 EFE39333.1 - 0.0092 15.2 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.22 EFE39333.1 - 0.018 15.3 0.1 0.034 14.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 EFE39333.1 - 0.051 13.2 0.0 0.08 12.6 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase AAA_24 PF13479.1 EFE39333.1 - 0.082 12.4 0.3 0.17 11.4 0.0 1.7 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EFE39333.1 - 0.097 12.2 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 EFE39333.1 - 0.11 12.4 0.7 0.2 11.6 0.3 1.5 1 1 0 1 1 1 0 AAA domain F-box-like PF12937.2 EFE39334.1 - 9.7e-06 25.2 0.5 5.8e-05 22.7 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EFE39334.1 - 0.034 13.8 0.0 0.11 12.1 0.0 2.0 1 0 0 1 1 1 0 F-box domain Brix PF04427.13 EFE39335.1 - 4.5e-32 111.2 0.0 6.3e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain CDC45 PF02724.9 EFE39335.1 - 0.0082 14.2 2.7 0.013 13.5 1.9 1.4 1 0 0 1 1 1 1 CDC45-like protein DUF1356 PF07092.7 EFE39335.1 - 0.05 12.7 0.0 0.069 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) DUF2551 PF10826.3 EFE39335.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2551) Nop14 PF04147.7 EFE39335.1 - 0.17 9.8 8.0 0.26 9.1 5.6 1.2 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.6 EFE39335.1 - 1.1 7.2 5.2 1.7 6.6 3.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 XRCC4 PF06632.7 EFE39339.1 - 8e-06 24.9 15.1 2.3e-05 23.4 10.5 1.8 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3585 PF12130.3 EFE39339.1 - 0.0083 15.9 5.5 0.012 15.4 3.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3585) DUF4407 PF14362.1 EFE39339.1 - 0.017 14.0 11.6 0.025 13.5 8.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.3 EFE39339.1 - 0.41 10.4 9.7 0.29 10.9 2.6 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding FlxA PF14282.1 EFE39339.1 - 0.69 9.8 8.7 2.1 8.3 6.0 1.8 1 0 0 1 1 1 0 FlxA-like protein IncA PF04156.9 EFE39339.1 - 0.91 9.0 7.0 1.5 8.3 4.8 1.4 1 0 0 1 1 1 0 IncA protein DUF3837 PF12939.2 EFE39339.1 - 2.1 8.3 9.1 7.2 6.6 0.4 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3837) Molybdopterin PF00384.17 EFE39340.1 - 1e-70 238.6 0.0 1.6e-68 231.4 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH-G_4Fe-4S_3 PF10588.4 EFE39340.1 - 4.2e-19 67.4 0.1 1.1e-18 66.1 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region DUF1982 PF09326.6 EFE39340.1 - 6.8e-08 32.5 0.0 1.7e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1982) TPP_enzyme_M PF00205.17 EFE39340.1 - 0.031 14.0 0.0 0.78 9.4 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4_19 PF06902.6 EFE39340.1 - 0.068 13.0 1.8 0.99 9.2 1.2 2.5 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Fer4 PF00037.22 EFE39340.1 - 0.093 12.3 1.1 2.6 7.8 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.2 EFE39340.1 - 0.37 10.7 3.3 0.39 10.6 0.9 2.0 2 0 0 2 2 2 0 4Fe-4S binding domain TPT PF03151.11 EFE39341.1 - 2.7e-38 131.0 4.5 2.7e-38 131.0 3.1 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 EFE39341.1 - 3.6e-07 29.3 19.2 3.5e-06 26.1 13.3 2.1 1 1 0 1 1 1 1 UAA transporter family PSII PF00421.14 EFE39341.1 - 0.00027 19.6 1.4 0.00047 18.8 1.0 1.3 1 0 0 1 1 1 1 Photosystem II protein EamA PF00892.15 EFE39341.1 - 0.13 12.3 37.5 0.055 13.5 8.1 3.3 3 2 0 3 3 3 0 EamA-like transporter family Peptidase_S9 PF00326.16 EFE39342.1 - 1.2e-06 27.8 0.8 2.1e-06 27.1 0.6 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFE39342.1 - 0.00089 19.0 0.2 0.0021 17.8 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFE39342.1 - 0.17 11.2 0.1 1.1 8.6 0.0 2.1 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase PUF PF00806.14 EFE39343.1 - 4.6e-32 107.6 1.5 4.2e-06 25.9 0.0 8.2 8 0 0 8 8 8 6 Pumilio-family RNA binding repeat RraB PF06877.6 EFE39343.1 - 0.044 14.4 0.0 0.23 12.1 0.0 2.1 2 0 0 2 2 2 0 Regulator of ribonuclease activity B DUF3355 PF11835.3 EFE39343.1 - 0.069 12.9 0.2 0.2 11.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3355) Ssl1 PF04056.9 EFE39345.1 - 1.1e-73 246.9 0.0 1.6e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 EFE39345.1 - 2.2e-17 62.8 8.7 2.2e-17 62.8 6.1 2.5 2 1 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.1 EFE39345.1 - 3.5e-09 37.0 0.0 5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Tfb4 PF03850.9 EFE39345.1 - 0.0009 18.5 3.8 0.0009 18.5 2.7 2.0 2 0 0 2 2 2 1 Transcription factor Tfb4 DZR PF12773.2 EFE39345.1 - 5.1 7.0 20.8 5.4 6.9 4.1 3.3 2 1 0 2 2 2 0 Double zinc ribbon CDC45 PF02724.9 EFE39345.1 - 6.3 4.7 6.2 8.1 4.3 4.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M1 PF01433.15 EFE39346.1 - 2.1e-118 395.8 8.0 4.8e-82 276.1 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M1 ERAP1_C PF11838.3 EFE39346.1 - 2.7e-80 270.0 0.0 4.2e-80 269.4 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EFE39346.1 - 3.1e-16 59.5 1.6 4.3e-16 59.1 0.4 1.7 2 0 0 2 2 2 1 Peptidase MA superfamily Ras PF00071.17 EFE39347.1 - 3.5e-23 81.7 0.4 4.2e-23 81.4 0.3 1.1 1 0 0 1 1 1 1 Ras family EIIBC-GUT_N PF03612.9 EFE39348.1 - 0.13 11.8 2.6 0.2 11.2 1.8 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Mito_carr PF00153.22 EFE39349.1 - 1.1e-55 185.3 2.2 7.1e-19 67.3 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.11 EFE39349.1 - 0.0035 17.1 0.2 0.0087 15.8 0.1 1.7 1 0 0 1 1 1 1 UcrQ family TnpW PF14202.1 EFE39349.1 - 0.048 13.2 0.2 0.12 11.9 0.1 1.7 1 0 0 1 1 1 0 Transposon-encoded protein TnpW Arteri_Gl PF00951.13 EFE39349.1 - 0.088 12.4 0.3 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein HMD PF03201.11 EFE39349.1 - 0.11 12.4 0.0 9.8 6.1 0.0 3.1 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase ATP_synt_I PF03899.10 EFE39349.1 - 0.18 12.0 6.3 3.5 7.8 0.0 3.7 2 1 2 4 4 4 0 ATP synthase I chain WD40 PF00400.27 EFE39350.1 - 0.0053 16.6 10.1 0.14 12.0 0.2 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat UPF0029 PF01205.14 EFE39351.1 - 6.9e-33 112.6 0.1 1.2e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 EFE39351.1 - 5e-07 29.6 0.0 9.2e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 RWD domain Glyco_hydro_61 PF03443.9 EFE39352.1 - 0.00025 20.9 0.0 0.00045 20.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Chitin_bind_3 PF03067.10 EFE39352.1 - 0.012 15.9 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Chitin binding domain Herpes_capsid PF06112.6 EFE39352.1 - 2.9 7.9 7.3 5.8 6.9 5.1 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Ribos_L4_asso_C PF14374.1 EFE39354.1 - 2e-30 104.4 0.7 4.1e-30 103.4 0.2 1.7 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ribosomal_L4 PF00573.17 EFE39354.1 - 4.7e-28 97.8 0.1 6.8e-28 97.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DSPc PF00782.15 EFE39355.1 - 6.7e-08 32.1 0.0 8.7e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain BCS1_N PF08740.6 EFE39356.1 - 3.4e-36 124.6 1.4 6e-36 123.8 1.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 EFE39356.1 - 2.9e-17 63.1 0.0 4.6e-15 55.9 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE39356.1 - 0.0014 19.3 0.0 0.0091 16.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 EFE39356.1 - 0.0069 15.4 0.0 0.017 14.1 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus KaiC PF06745.8 EFE39356.1 - 0.0091 15.1 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 EFE39356.1 - 0.016 14.6 0.0 0.047 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EFE39356.1 - 0.074 12.7 0.0 0.27 10.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFE39356.1 - 0.084 12.8 0.5 0.51 10.2 0.2 2.4 2 1 0 2 2 2 0 AAA ATPase domain NAAA-beta PF15508.1 EFE39357.1 - 5.2e-14 52.3 0.0 7.5e-08 32.6 0.0 3.3 2 1 1 3 3 3 2 beta subunit of N-acylethanolamine-hydrolyzing acid amidase DUF3395 PF11875.3 EFE39358.1 - 1.1e-39 135.4 0.0 2.2e-39 134.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.26 EFE39358.1 - 2.7e-15 55.8 0.0 6.7e-15 54.5 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain CcmD PF04995.9 EFE39358.1 - 5.2 6.8 6.9 15 5.4 4.8 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Mito_fiss_reg PF05308.6 EFE39360.1 - 7.8 5.7 7.3 13 5.0 5.1 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator SKIP_SNW PF02731.10 EFE39361.1 - 2.9e-68 228.2 5.8 2.9e-68 228.2 4.0 2.5 3 0 0 3 3 3 1 SKIP/SNW domain WD40 PF00400.27 EFE39362.1 - 9.5e-48 158.4 40.3 7.4e-12 44.6 0.4 12.6 13 0 0 13 13 13 8 WD domain, G-beta repeat Utp12 PF04003.7 EFE39362.1 - 1.4e-29 102.2 0.0 2.2e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.6 EFE39362.1 - 2.6e-08 33.7 0.8 0.0072 16.0 0.0 5.2 6 1 0 7 7 7 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 EFE39362.1 - 3.7e-08 31.9 3.6 0.11 10.5 0.0 4.8 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Pox_T4_N PF04491.7 EFE39362.1 - 0.022 14.5 0.6 0.08 12.7 0.1 2.1 2 0 0 2 2 2 0 Poxvirus T4 protein, N terminus IKI3 PF04762.7 EFE39362.1 - 0.065 11.0 0.2 5 4.8 0.0 2.9 2 1 0 3 3 3 0 IKI3 family Hemagglutinin PF00509.13 EFE39362.1 - 0.11 10.5 0.0 0.17 9.9 0.0 1.2 1 0 0 1 1 1 0 Haemagglutinin Coatomer_WDAD PF04053.9 EFE39362.1 - 0.16 10.7 0.0 7 5.3 0.0 3.2 4 0 0 4 4 4 0 Coatomer WD associated region Septin PF00735.13 EFE39363.1 - 2.5e-110 367.9 0.3 3.8e-110 367.3 0.2 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EFE39363.1 - 1.1e-06 28.5 0.0 2.5e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFE39363.1 - 4.2e-05 23.0 0.2 0.00066 19.1 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EFE39363.1 - 9.9e-05 21.5 0.0 0.00026 20.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFE39363.1 - 0.015 15.4 0.0 0.052 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EFE39363.1 - 0.033 13.7 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 EFE39363.1 - 0.037 14.5 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AIG1 PF04548.11 EFE39363.1 - 0.074 12.1 0.1 0.18 10.8 0.0 1.7 2 0 0 2 2 2 0 AIG1 family Dynamin_N PF00350.18 EFE39363.1 - 0.082 12.7 3.7 1.3 8.8 0.0 3.0 2 1 1 3 3 3 0 Dynamin family Ras PF00071.17 EFE39363.1 - 0.12 11.7 0.3 0.34 10.3 0.2 1.7 1 1 0 1 1 1 0 Ras family ATP_bind_1 PF03029.12 EFE39363.1 - 0.22 11.0 0.6 10 5.5 0.1 2.4 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Sigma_reg_C PF13791.1 EFE39363.1 - 0.26 11.3 1.4 0.32 11.0 0.2 1.7 2 0 0 2 2 2 0 Sigma factor regulator C-terminal Myc-LZ PF02344.10 EFE39363.1 - 1.2 8.8 5.4 1.1 8.8 0.2 2.4 2 0 0 2 2 2 0 Myc leucine zipper domain WD40 PF00400.27 EFE39364.1 - 5.3e-26 89.5 18.6 1.3e-05 24.8 0.4 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat PQQ PF01011.16 EFE39364.1 - 0.00063 19.1 0.0 0.39 10.3 0.0 3.3 3 0 0 3 3 3 2 PQQ enzyme repeat VID27 PF08553.5 EFE39364.1 - 0.074 11.2 0.1 0.12 10.6 0.0 1.2 1 0 0 1 1 1 0 VID27 cytoplasmic protein ACT_7 PF13840.1 EFE39365.1 - 7.3e-20 70.2 0.1 1.7e-10 40.2 0.0 2.5 2 1 0 2 2 2 2 ACT domain XRN_N PF03159.13 EFE39366.1 - 1.8e-104 348.2 0.0 2.9e-104 347.6 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus WD40 PF00400.27 EFE39367.1 - 4.3e-43 143.7 4.5 5.9e-09 35.4 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 EFE39367.1 - 6.5e-31 106.0 0.8 1.5e-30 104.8 0.6 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex GTP_cyclohydroI PF01227.17 EFE39368.1 - 4e-68 228.2 0.1 6.4e-68 227.5 0.1 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 EFE39368.1 - 0.00061 19.6 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein DUF4243 PF14027.1 EFE39370.1 - 2.8e-102 342.5 0.1 3.3e-102 342.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) Lactamase_B_5 PF14597.1 EFE39370.1 - 0.062 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Pkinase PF00069.20 EFE39371.1 - 6e-71 238.6 0.0 9.3e-71 238.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39371.1 - 1.7e-33 115.8 0.0 3.2e-33 114.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE39371.1 - 5.4e-05 22.3 0.3 0.00013 21.1 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE39371.1 - 0.00043 19.3 0.7 0.0023 16.9 0.1 2.1 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 EFE39371.1 - 0.081 12.6 11.1 0.17 11.6 0.1 3.9 3 1 0 3 3 3 0 Phosphotransferase enzyme family NUDIX PF00293.23 EFE39372.1 - 2.1e-15 56.5 0.0 4.1e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.6 EFE39372.1 - 9.1e-11 41.9 0.0 8.5e-10 38.8 0.0 2.4 3 0 0 3 3 3 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.6 EFE39372.1 - 7.2e-07 28.6 1.3 1.2e-06 27.8 0.9 1.3 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain GFA PF04828.9 EFE39372.1 - 0.1 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Dynamin_N PF00350.18 EFE39374.1 - 3e-18 66.2 0.0 6.9e-18 65.0 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFE39374.1 - 3.1e-07 29.4 0.1 3.6e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 Dynamin central region FeoB_N PF02421.13 EFE39374.1 - 3.7e-05 23.0 0.5 0.03 13.6 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B MMR_HSR1 PF01926.18 EFE39374.1 - 0.0044 16.9 0.0 0.029 14.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.13 EFE39374.1 - 0.016 15.0 0.5 0.057 13.3 0.1 2.1 2 0 0 2 2 2 0 Dynamin GTPase effector domain AAA_23 PF13476.1 EFE39374.1 - 0.032 14.5 0.1 1.7 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Methyltransf_13 PF08421.6 EFE39374.1 - 0.12 11.8 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Putative zinc binding domain Helicase_C_3 PF13625.1 EFE39375.1 - 9.1e-26 90.1 0.0 6.3e-25 87.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE39375.1 - 5.8e-13 49.0 0.0 1.3e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EFE39375.1 - 8.4e-13 47.9 0.0 1.8e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFE39375.1 - 1.7e-10 40.1 0.1 2.8e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_34 PF13872.1 EFE39375.1 - 0.0085 14.8 0.0 0.014 14.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF3669 PF12417.3 EFE39376.1 - 2.7e-22 78.2 0.0 7.6e-22 76.8 0.0 1.7 2 0 0 2 2 2 1 Zinc finger protein DUF3669 PF12417.3 EFE39377.1 - 1.4e-19 69.5 0.0 2.9e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Zinc finger protein CTD_bind PF04818.8 EFE39378.1 - 2e-05 24.7 0.0 5.5e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. PAT1 PF09770.4 EFE39378.1 - 3.6 5.7 24.4 6.8 4.7 16.9 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EMP24_GP25L PF01105.19 EFE39379.1 - 4.6e-42 143.7 0.0 7.8e-42 143.0 0.0 1.3 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD USP7_ICP0_bdg PF12436.3 EFE39380.1 - 2.3e-86 289.0 0.0 4.7e-85 284.8 0.0 2.3 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 EFE39380.1 - 9e-58 195.1 2.8 1.1e-47 162.1 0.3 3.5 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.24 EFE39380.1 - 2.5e-51 174.3 0.4 4.3e-51 173.6 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE39380.1 - 8.4e-32 110.7 0.0 1.5e-31 109.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rad60-SLD PF11976.3 EFE39380.1 - 0.036 13.7 0.6 1.3 8.7 0.0 3.6 4 1 0 4 4 4 0 Ubiquitin-2 like Rad60 SUMO-like BCDHK_Adom3 PF10436.4 EFE39382.1 - 2.9e-29 101.6 0.0 6.5e-29 100.5 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EFE39382.1 - 3.9e-11 42.6 0.0 8.6e-10 38.3 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EFE39382.1 - 0.0039 16.9 0.0 0.63 9.8 0.0 2.4 2 0 0 2 2 2 2 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.1 EFE39382.1 - 0.0091 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SPC22 PF04573.7 EFE39383.1 - 1.3e-33 115.6 0.1 2.8e-25 88.5 0.0 2.1 1 1 0 2 2 2 2 Signal peptidase subunit Peptidase_C48 PF02902.14 EFE39384.1 - 1.5e-32 112.9 0.1 1e-31 110.2 0.1 2.0 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain IF4E PF01652.13 EFE39386.1 - 6e-50 168.9 0.1 1e-49 168.2 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Aminotran_1_2 PF00155.16 EFE39387.1 - 8e-27 94.1 0.0 1e-26 93.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_3 PF00202.16 EFE39387.1 - 0.18 10.6 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III POT1 PF02765.12 EFE39388.1 - 2.5e-12 46.9 0.0 4.4e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 FMO-like PF00743.14 EFE39389.1 - 2e-41 141.7 0.0 5.6e-23 80.9 0.0 3.0 2 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFE39389.1 - 1.4e-13 51.3 0.0 7.1e-13 49.0 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE39389.1 - 1.5e-07 31.5 0.0 3.5e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE39389.1 - 1.1e-06 27.8 0.0 6.5e-06 25.3 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFE39389.1 - 4.5e-06 26.5 0.0 1.3e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFE39389.1 - 5.8e-06 26.1 0.0 6.2e-05 22.8 0.1 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 EFE39389.1 - 0.0012 18.0 0.0 0.035 13.2 0.0 2.1 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.9 EFE39389.1 - 0.14 10.5 0.0 0.46 8.8 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Semialdhyde_dh PF01118.19 EFE39389.1 - 0.16 12.2 0.0 7.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain TFIIA PF03153.8 EFE39390.1 - 0.3 10.9 5.2 0.47 10.2 3.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HDA2-3 PF11496.3 EFE39391.1 - 8.8e-36 123.2 0.0 1.8e-34 118.9 0.0 2.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Fez1 PF06818.10 EFE39391.1 - 0.0015 18.5 18.8 0.0015 18.5 13.0 2.6 1 1 1 2 2 2 1 Fez1 Reo_sigmaC PF04582.7 EFE39391.1 - 0.99 8.5 11.1 0.44 9.6 0.9 2.7 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Fib_alpha PF08702.5 EFE39391.1 - 1.1 9.3 25.5 1.1 9.3 6.4 3.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Bcr-Abl_Oligo PF09036.5 EFE39391.1 - 1.1 9.2 6.6 0.69 9.9 0.2 3.6 1 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Laminin_II PF06009.7 EFE39391.1 - 1.3 8.7 22.5 0.045 13.5 6.3 3.6 1 1 3 4 4 4 0 Laminin Domain II CENP-F_leu_zip PF10473.4 EFE39391.1 - 6.7 6.5 48.8 2.1 8.2 12.3 3.7 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.6 EFE39391.1 - 9.8 4.7 33.2 3.3 6.2 15.4 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein MIP PF00230.15 EFE39392.1 - 2.8e-43 147.9 10.8 3.5e-43 147.6 7.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein Transglut_core PF01841.14 EFE39393.1 - 1.1e-11 44.9 0.2 2.9e-11 43.5 0.1 1.8 2 0 0 2 2 2 1 Transglutaminase-like superfamily SH3_2 PF07653.12 EFE39393.1 - 9.9e-09 34.5 0.2 2.6e-08 33.1 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EFE39393.1 - 3.4e-06 26.5 0.1 4.7e-05 22.8 0.1 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 EFE39393.1 - 5e-06 25.7 0.0 5e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 SH3 domain Transglut_core2 PF13369.1 EFE39393.1 - 0.19 11.1 0.0 0.43 10.0 0.0 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily DHHA2 PF02833.9 EFE39394.1 - 1.5e-17 63.9 0.0 3.2e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.15 EFE39394.1 - 3.5e-07 29.9 0.0 1.1e-06 28.3 0.0 1.9 1 1 0 1 1 1 1 DHH family Zn_clus PF00172.13 EFE39395.1 - 5.2e-07 29.4 12.2 1.2e-06 28.3 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_11 PF13414.1 EFE39397.1 - 7.8e-29 99.1 8.5 8.7e-10 38.1 0.0 7.5 7 0 0 7 7 7 4 TPR repeat TPR_2 PF07719.12 EFE39397.1 - 1.8e-25 86.7 8.3 0.0038 17.0 0.0 10.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.23 EFE39397.1 - 1.1e-22 78.6 8.2 0.0019 17.7 0.3 9.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_12 PF13424.1 EFE39397.1 - 2.8e-15 55.9 23.1 4.1e-08 33.0 0.3 8.4 7 1 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.1 EFE39397.1 - 2.7e-11 42.4 4.9 0.013 15.2 0.0 7.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE39397.1 - 1.1e-10 41.9 18.5 0.0013 19.3 0.2 7.9 6 2 2 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFE39397.1 - 4.8e-10 39.1 14.7 0.24 12.1 0.2 8.1 6 2 3 9 9 8 3 Tetratricopeptide repeat Apc3 PF12895.2 EFE39397.1 - 6.7e-10 38.9 12.7 1.8e-05 24.8 0.2 5.9 5 1 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 EFE39397.1 - 3.3e-09 36.9 10.9 0.15 12.3 0.0 6.4 6 1 2 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.1 EFE39397.1 - 8.6e-07 28.6 4.1 0.79 10.0 0.0 7.2 8 1 0 8 8 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE39397.1 - 2.7e-06 26.7 15.2 2.1 8.3 0.0 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_10 PF13374.1 EFE39397.1 - 0.00014 21.6 18.3 0.0026 17.6 0.1 6.6 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.1 EFE39397.1 - 0.00043 20.5 5.9 13 6.4 0.1 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFE39397.1 - 0.078 13.4 8.6 0.2 12.1 0.3 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat Trefoil PF00088.13 EFE39397.1 - 0.28 10.8 2.1 0.6 9.7 1.5 1.5 1 0 0 1 1 1 0 Trefoil (P-type) domain DUF572 PF04502.8 EFE39398.1 - 3.3e-72 243.4 14.2 4e-72 243.1 9.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Benyvirus_14KDa PF07255.6 EFE39398.1 - 0.004 17.0 0.2 0.0069 16.2 0.1 1.3 1 0 0 1 1 1 1 Benyvirus 14KDa protein DUF866 PF05907.8 EFE39398.1 - 0.015 14.8 2.5 0.016 14.6 0.8 1.7 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) zf-FCS PF06467.9 EFE39398.1 - 0.045 13.4 3.2 0.22 11.2 0.2 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zinc_ribbon_5 PF13719.1 EFE39398.1 - 0.058 12.9 0.4 9.7 5.8 0.0 2.6 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 EFE39398.1 - 0.068 12.4 3.8 0.75 9.1 1.0 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.1 EFE39398.1 - 0.083 12.5 0.4 9.4 6.0 0.0 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 EFE39398.1 - 0.11 11.7 0.3 0.52 9.5 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain PMT_C PF11647.3 EFE39398.1 - 0.11 12.1 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 C-terminal region of Pasteurella multocida toxin residues 569-1285 DNA_RNApol_7kD PF03604.8 EFE39398.1 - 0.14 11.6 2.0 12 5.4 0.2 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit PcfJ PF14284.1 EFE39398.1 - 0.2 11.1 9.8 0.03 13.8 1.7 2.3 2 0 0 2 2 2 0 PcfJ-like protein FAT PF02259.18 EFE39399.1 - 7.8e-74 248.7 12.8 1.6e-73 247.7 8.9 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 EFE39399.1 - 1.1e-30 106.8 0.2 4.9e-30 104.7 0.1 2.2 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 EFE39399.1 - 3.9e-08 32.5 0.2 1.1e-07 31.1 0.1 1.8 1 0 0 1 1 1 1 FATC domain B56 PF01603.15 EFE39400.1 - 1.3e-171 570.7 5.6 1.6e-171 570.4 3.8 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Dynamin_N PF00350.18 EFE39400.1 - 0.11 12.3 0.4 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 Dynamin family Tau95 PF09734.4 EFE39401.1 - 4.9e-62 210.0 0.1 1.4e-61 208.4 0.1 1.7 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit Nop14 PF04147.7 EFE39401.1 - 1.7 6.4 8.8 2.3 6.0 6.1 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 EFE39401.1 - 2.6 6.4 9.7 3.4 6.0 6.7 1.1 1 0 0 1 1 1 0 Daxx Family RNA_pol_3_Rpc31 PF11705.3 EFE39401.1 - 6.8 6.5 17.2 14 5.5 11.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Filament_head PF04732.9 EFE39402.1 - 0.054 14.1 2.2 0.081 13.6 0.4 2.2 2 0 0 2 2 2 0 Intermediate filament head (DNA binding) region PPP4R2 PF09184.6 EFE39402.1 - 5.3 6.5 13.4 0.47 9.9 5.4 1.9 1 1 1 2 2 2 0 PPP4R2 PAN_1 PF00024.21 EFE39404.1 - 3.2e-08 33.1 24.5 0.00034 20.3 3.9 2.8 2 1 1 3 3 3 2 PAN domain PAN_3 PF08277.7 EFE39404.1 - 0.00083 18.9 7.1 0.072 12.7 0.2 2.7 2 0 0 2 2 2 2 PAN-like domain PAN_4 PF14295.1 EFE39404.1 - 0.0042 16.7 9.3 0.0076 15.9 2.8 3.8 4 0 0 4 4 4 2 PAN domain PfkB PF00294.19 EFE39405.1 - 1.5e-39 135.9 0.0 3.4e-39 134.7 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase ECH PF00378.15 EFE39406.1 - 2.8e-37 128.1 0.3 1.1e-25 90.1 0.2 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase family Antimicrobial_1 PF08018.6 EFE39406.1 - 1.4 8.9 3.6 3.6 7.5 0.3 2.4 2 0 0 2 2 2 0 Frog antimicrobial peptide MCM PF00493.18 EFE39407.1 - 1.4e-133 444.8 0.3 1.8e-133 444.4 0.2 1.1 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 EFE39407.1 - 6e-07 28.8 0.0 0.00012 21.3 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFE39407.1 - 1.8e-05 24.5 0.0 3.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EFE39407.1 - 0.00089 18.8 0.1 0.0039 16.8 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFE39407.1 - 0.012 15.0 0.1 0.18 11.2 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain Lon_2 PF13337.1 EFE39407.1 - 0.023 13.0 0.1 0.41 8.9 0.0 2.1 2 0 0 2 2 2 0 Putative ATP-dependent Lon protease Mg_chelatase_2 PF13335.1 EFE39407.1 - 0.075 13.4 1.2 0.17 12.3 0.4 2.0 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI SET PF00856.23 EFE39408.1 - 4.2e-09 36.9 0.0 1.2e-08 35.4 0.0 1.8 1 0 0 1 1 1 1 SET domain DEAD PF00270.24 EFE39410.1 - 2e-31 108.7 0.1 5.1e-31 107.4 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE39410.1 - 7.5e-17 60.9 0.0 2.1e-16 59.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFE39410.1 - 0.00019 20.3 0.0 0.0003 19.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EFE39410.1 - 0.00087 19.1 0.5 0.013 15.3 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Anillin PF08174.6 EFE39411.1 - 3.5e-31 108.1 0.4 1.2e-30 106.4 0.3 1.9 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.24 EFE39411.1 - 8.2e-08 32.3 0.0 2.8e-07 30.6 0.0 2.0 1 0 0 1 1 1 1 PH domain PseudoU_synth_1 PF01416.15 EFE39412.1 - 2.2e-23 82.6 0.0 1.1e-10 41.9 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase TrkH PF02386.11 EFE39414.1 - 5.2e-76 255.5 6.2 5e-74 249.0 1.1 2.4 2 1 0 2 2 2 2 Cation transport protein NnrU PF07298.6 EFE39414.1 - 0.1 11.9 2.2 0.23 10.8 1.5 1.5 1 0 0 1 1 1 0 NnrU protein MFS_1 PF07690.11 EFE39415.1 - 3.4e-11 42.4 54.2 3.4e-11 42.4 37.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily PALP PF00291.20 EFE39416.1 - 8.7e-47 159.8 0.2 1.1e-46 159.5 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Phenyl_P_gamma PF09662.5 EFE39417.1 - 0.12 12.1 0.1 0.36 10.5 0.1 1.8 1 1 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) DUF3517 PF12030.3 EFE39418.1 - 5.2e-109 363.8 0.6 9.9e-109 362.9 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.24 EFE39418.1 - 1.4e-46 158.7 0.0 2.2e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE39418.1 - 8.4e-15 54.9 0.0 1.3e-07 31.3 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Glyco_tranf_2_4 PF13704.1 EFE39418.1 - 0.054 13.8 0.3 0.18 12.1 0.2 1.9 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF4110 PF13422.1 EFE39418.1 - 0.2 11.5 0.0 0.55 10.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) RNase_P_pop3 PF08228.6 EFE39419.1 - 2.1e-05 24.4 0.0 3.9e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 RNase P subunit Pop3 PC4 PF02229.11 EFE39419.1 - 0.089 12.0 0.0 0.24 10.6 0.0 1.7 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) Hexapep PF00132.19 EFE39420.1 - 2.1e-14 52.2 9.1 1.7e-11 43.0 3.9 3.1 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFE39420.1 - 7.9e-12 44.5 9.6 3.4e-11 42.5 2.6 2.8 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.3 EFE39420.1 - 6.7e-10 38.8 0.2 1e-09 38.2 0.1 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Ank_2 PF12796.2 EFE39421.1 - 5.3e-45 151.6 8.4 1.1e-15 57.7 0.2 4.8 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.25 EFE39421.1 - 1.9e-37 125.2 22.8 7.9e-10 38.0 0.1 9.2 11 0 0 11 11 11 7 Ankyrin repeat Ank_4 PF13637.1 EFE39421.1 - 1.3e-36 124.3 15.1 1.3e-07 31.9 0.0 7.3 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE39421.1 - 2.2e-36 123.0 16.1 6.5e-10 38.9 0.2 6.6 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE39421.1 - 6.4e-29 97.1 13.9 3.2e-07 29.9 0.0 8.6 8 0 0 8 8 8 6 Ankyrin repeat AIRC PF00731.15 EFE39422.1 - 1.1e-59 200.0 1.6 1.9e-59 199.2 1.1 1.4 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.17 EFE39422.1 - 1.2e-43 148.4 0.0 1.2e-42 145.2 0.0 2.3 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 EFE39422.1 - 4.4e-07 29.8 0.0 0.003 17.3 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain PrpR_N PF06506.6 EFE39422.1 - 0.0017 17.7 1.3 0.022 14.1 0.1 2.5 2 0 0 2 2 2 1 Propionate catabolism activator CPSase_L_D2 PF02786.12 EFE39422.1 - 0.0021 17.3 0.6 0.14 11.4 0.0 2.8 2 1 1 3 3 3 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.1 EFE39422.1 - 0.0084 14.8 0.0 1.3 7.6 0.0 2.8 3 0 0 3 3 3 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EFE39422.1 - 0.015 14.6 0.0 1.5 8.1 0.0 2.4 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus CoA_binding_2 PF13380.1 EFE39422.1 - 0.056 13.6 1.3 13 6.0 0.0 3.3 2 1 1 3 3 3 0 CoA binding domain 2-Hacid_dh_C PF02826.14 EFE39422.1 - 0.085 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SCA7 PF08313.7 EFE39423.1 - 7.1e-34 115.2 0.4 7.1e-34 115.2 0.3 2.3 2 0 0 2 2 2 1 SCA7, zinc-binding domain Neugrin PF06413.6 EFE39423.1 - 0.37 10.5 7.2 0.7 9.6 5.0 1.5 1 0 0 1 1 1 0 Neugrin CDC45 PF02724.9 EFE39423.1 - 4 5.3 6.1 5.6 4.8 4.2 1.2 1 0 0 1 1 1 0 CDC45-like protein mRNA_cap_enzyme PF01331.14 EFE39424.1 - 8.1e-52 175.7 0.8 1.1e-51 175.3 0.6 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 EFE39424.1 - 1.6e-24 86.2 0.0 3.1e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 EFE39424.1 - 1e-08 34.8 1.0 3.6e-07 29.7 0.7 2.4 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_M PF01068.16 EFE39425.1 - 8.8e-57 191.7 0.9 7e-45 152.8 0.1 2.6 3 0 0 3 3 3 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EFE39425.1 - 6.1e-54 182.5 0.2 1.1e-53 181.7 0.1 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EFE39425.1 - 5.5e-28 97.2 0.0 3.1e-27 94.8 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region MotA_ExbB PF01618.11 EFE39425.1 - 0.89 9.1 0.0 0.89 9.1 0.0 2.7 3 0 0 3 3 3 0 MotA/TolQ/ExbB proton channel family PT PF04886.7 EFE39426.1 - 0.0013 18.0 20.4 0.47 9.8 10.9 3.4 2 1 0 2 2 2 1 PT repeat FA_desaturase PF00487.19 EFE39427.1 - 0.83 9.0 3.4 0.85 9.0 2.4 1.0 1 0 0 1 1 1 0 Fatty acid desaturase Virul_fac_BrkB PF03631.10 EFE39427.1 - 2.1 7.6 7.9 2.7 7.2 5.5 1.1 1 0 0 1 1 1 0 Virulence factor BrkB Pkinase PF00069.20 EFE39428.1 - 4.8e-67 225.8 0.0 1e-66 224.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39428.1 - 4.9e-31 107.7 0.0 7.8e-30 103.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE39428.1 - 2.5e-05 23.3 0.0 4.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE39428.1 - 0.0079 15.9 0.0 0.032 13.9 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family DAO PF01266.19 EFE39429.1 - 8e-20 71.0 0.0 1.1e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFE39429.1 - 0.012 15.4 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFE39429.1 - 0.018 14.9 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1690 PF07956.6 EFE39430.1 - 1.1e-24 86.9 0.2 1e-12 48.2 0.0 2.2 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) PP2C_C PF07830.8 EFE39430.1 - 0.067 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain POP1 PF06978.6 EFE39431.1 - 1.1e-64 217.5 12.7 2.1e-64 216.6 8.8 1.5 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 EFE39431.1 - 4.5e-31 106.5 2.3 1.1e-30 105.2 1.6 1.7 1 0 0 1 1 1 1 POPLD (NUC188) domain Redoxin PF08534.5 EFE39432.1 - 3.8e-35 120.5 0.0 4.6e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EFE39432.1 - 1.1e-13 50.9 0.0 1.5e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Hexokinase_2 PF03727.11 EFE39433.1 - 2.1e-65 220.3 0.0 3e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 EFE39433.1 - 1.4e-63 213.9 0.0 2.4e-63 213.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase zf-C2HC5 PF06221.8 EFE39433.1 - 4.3e-21 74.4 5.7 8.5e-21 73.4 3.9 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Phospholip_A2_3 PF09056.6 EFE39434.1 - 1.3e-36 125.1 4.0 1.6e-36 124.9 2.8 1.1 1 0 0 1 1 1 1 Prokaryotic phospholipase A2 DUF604 PF04646.7 EFE39436.1 - 6.5e-06 25.5 0.0 1.1e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Fringe PF02434.11 EFE39436.1 - 0.00071 18.8 0.0 0.0016 17.6 0.0 1.6 1 1 0 1 1 1 1 Fringe-like GDI PF00996.13 EFE39438.1 - 2.6e-42 144.6 0.0 3.4e-42 144.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Pro_isomerase PF00160.16 EFE39439.1 - 8e-44 149.5 0.0 9.6e-44 149.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_A22B PF04258.8 EFE39440.1 - 6.7e-52 176.7 0.0 2e-51 175.2 0.0 1.7 1 1 0 1 1 1 1 Signal peptide peptidase RNase_PH PF01138.16 EFE39441.1 - 7.2e-09 36.0 0.2 2.8e-07 30.8 0.1 2.3 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 Ferric_reduct PF01794.14 EFE39442.1 - 4.2e-10 39.7 1.0 4.2e-10 39.7 0.7 2.7 3 1 1 4 4 4 1 Ferric reductase like transmembrane component Dispanin PF04505.7 EFE39442.1 - 0.097 12.2 0.2 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 Interferon-induced transmembrane protein DUF4405 PF14358.1 EFE39442.1 - 5.6 7.1 9.4 0.069 13.3 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) NAD_binding_6 PF08030.7 EFE39443.1 - 8.7e-21 74.4 0.0 3.5e-20 72.4 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFE39443.1 - 2.7e-12 46.4 0.1 9.7e-12 44.6 0.0 2.0 1 1 1 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.16 EFE39443.1 - 0.00036 21.0 0.0 0.61 10.6 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain Acetyltransf_1 PF00583.19 EFE39444.1 - 0.00028 20.8 0.0 0.08 12.9 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Sgf11 PF08209.6 EFE39445.1 - 3e-07 29.6 1.6 2.4e-06 26.7 0.0 2.5 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) Tetraspannin PF00335.15 EFE39446.1 - 9.1e-09 34.9 4.2 1.2e-08 34.5 2.9 1.1 1 0 0 1 1 1 1 Tetraspanin family MASE1 PF05231.9 EFE39446.1 - 0.0087 15.1 3.4 0.0087 15.1 1.3 1.7 2 0 0 2 2 2 1 MASE1 HGWP PF03578.10 EFE39446.1 - 0.53 9.6 2.4 1.8 7.9 1.4 2.0 2 0 0 2 2 2 0 HGWP repeat PGPGW PF09656.5 EFE39446.1 - 0.97 8.7 5.2 0.44 9.8 0.2 2.4 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) SRF-TF PF00319.13 EFE39447.1 - 1.3e-09 37.1 3.6 7.3e-08 31.5 2.5 2.3 1 1 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF3439 PF11921.3 EFE39447.1 - 0.012 15.3 3.5 0.025 14.3 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Lactonase PF10282.4 EFE39448.1 - 3.4e-85 286.1 0.0 4.2e-85 285.8 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Mg_trans_NIPA PF05653.9 EFE39449.1 - 7e-10 38.3 0.9 9.4e-10 37.9 0.6 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA TMEM61 PF15105.1 EFE39449.1 - 0.017 14.6 0.1 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 TMEM61 protein family vATP-synt_E PF01991.13 EFE39451.1 - 3.7e-56 189.5 11.2 4.2e-56 189.3 7.8 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4288 PF14119.1 EFE39451.1 - 0.035 14.2 6.0 6.8 6.8 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4288) Scaffolding_pro PF11418.3 EFE39451.1 - 1 9.7 5.0 0.68 10.2 1.3 2.1 2 0 0 2 2 2 0 Phi29 scaffolding protein E1-E2_ATPase PF00122.15 EFE39453.1 - 3.2e-12 45.9 0.0 9e-12 44.5 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 EFE39453.1 - 4e-12 45.9 0.0 1e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE39453.1 - 9.3e-12 45.5 0.0 2.6e-11 44.0 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFE39453.1 - 1.1e-11 45.5 1.6 4.7e-08 33.6 0.6 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE39453.1 - 0.022 14.3 0.2 0.052 13.1 0.1 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SEN1_N PF12726.2 EFE39454.1 - 2.3e-216 720.2 6.5 3e-216 719.8 4.5 1.1 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.1 EFE39454.1 - 4.2e-69 232.7 2.6 1.3e-68 231.0 1.8 1.9 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.1 EFE39454.1 - 8e-61 204.9 0.0 1.9e-60 203.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE39454.1 - 1.3e-11 44.0 0.1 4.1e-11 42.4 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EFE39454.1 - 6.5e-09 35.6 0.2 8.6e-06 25.4 0.1 2.5 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.16 EFE39454.1 - 7e-08 32.1 0.4 4.7e-06 26.1 0.3 2.7 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.13 EFE39454.1 - 1e-07 31.7 0.1 0.012 15.1 0.0 3.6 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DEAD PF00270.24 EFE39454.1 - 0.00076 19.0 0.5 0.0052 16.2 0.1 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EFE39454.1 - 0.002 17.9 0.0 0.0088 15.8 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SE PF00437.15 EFE39454.1 - 0.0044 15.9 0.0 0.012 14.5 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein zf-CCHC_5 PF14787.1 EFE39454.1 - 0.0061 16.0 7.5 0.18 11.3 0.1 2.7 1 1 1 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.18 EFE39454.1 - 0.0066 16.3 1.0 0.0066 16.3 0.7 3.0 3 0 0 3 3 2 2 Zinc knuckle AAA_25 PF13481.1 EFE39454.1 - 0.056 12.8 0.0 0.17 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EFE39454.1 - 0.1 12.9 3.7 0.07 13.4 0.4 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 EFE39454.1 - 0.12 12.5 0.7 5 7.2 0.0 3.4 4 0 0 4 4 3 0 AAA domain CAP59_mtransfer PF11735.3 EFE39455.1 - 7.6e-14 51.5 0.0 1.3e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DUF998 PF06197.8 EFE39455.1 - 0.054 12.8 0.2 0.08 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF998) CAP59_mtransfer PF11735.3 EFE39456.1 - 2.2e-39 135.1 2.7 3e-39 134.7 1.9 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 CorA PF01544.13 EFE39458.1 - 2e-08 33.6 0.0 3.4e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein WH1 PF00568.18 EFE39459.1 - 1.3e-28 98.8 0.0 2e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.15 EFE39459.1 - 0.0046 16.5 1.7 0.016 14.7 0.1 2.5 2 0 0 2 2 2 1 WH2 motif eIF-1a PF01176.14 EFE39461.1 - 1.2e-28 98.2 0.1 1.7e-28 97.7 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 ERCC4 PF02732.10 EFE39462.1 - 1.4e-24 86.4 0.0 1.5e-23 83.1 0.0 2.7 3 0 0 3 3 3 1 ERCC4 domain PTCB-BRCT PF12738.2 EFE39463.1 - 7e-13 48.2 0.0 1.3e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 EFE39463.1 - 1.1e-07 31.8 0.0 2.2e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain fn3 PF00041.16 EFE39463.1 - 0.002 18.2 0.0 0.0047 17.0 0.0 1.7 1 1 0 1 1 1 1 Fibronectin type III domain DUF605 PF04652.11 EFE39463.1 - 1.3 8.3 16.6 2 7.7 11.5 1.2 1 0 0 1 1 1 0 Vta1 like Peptidase_S10 PF00450.17 EFE39464.1 - 1.7e-86 290.9 0.0 2.5e-86 290.4 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_5 PF12695.2 EFE39464.1 - 0.093 12.4 0.0 0.35 10.6 0.0 2.0 2 1 0 2 2 2 0 Alpha/beta hydrolase family Acetyltransf_9 PF13527.1 EFE39465.1 - 0.012 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE39465.1 - 0.017 15.2 0.1 0.15 12.1 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFE39465.1 - 0.021 15.0 0.0 0.049 13.7 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE39465.1 - 0.021 14.8 0.0 0.065 13.2 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Acetyltransf_1 PF00583.19 EFE39466.1 - 1.3e-07 31.5 0.0 2.1e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 EFE39466.1 - 2.9e-06 27.1 0.1 9.9e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE39466.1 - 7.6e-06 26.0 0.0 0.0005 20.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFE39466.1 - 1.3e-05 25.2 0.0 1.9e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.1 EFE39466.1 - 0.0051 16.7 0.0 0.035 14.0 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFE39466.1 - 0.058 13.2 0.0 0.15 11.9 0.0 1.6 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase GFA PF04828.9 EFE39467.1 - 2.1e-10 40.4 1.7 6.1e-05 22.8 0.1 2.3 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme MFS_1 PF07690.11 EFE39468.1 - 4e-47 160.6 36.3 4e-47 160.6 25.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE39468.1 - 1.6e-10 40.1 9.3 1.6e-10 40.1 6.4 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFE39468.1 - 2.1e-06 26.2 1.9 2.1e-06 26.2 1.3 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Pho86 PF11124.3 EFE39468.1 - 0.093 11.7 0.3 2.5 7.0 0.0 2.1 2 0 0 2 2 2 0 Inorganic phosphate transporter Pho86 CAAD PF14159.1 EFE39468.1 - 1.2 8.8 0.0 1.2 8.8 0.0 3.4 4 0 0 4 4 4 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase MFS_1 PF07690.11 EFE39469.1 - 1.4e-18 66.7 59.3 1.8e-17 63.1 37.1 3.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE39469.1 - 1.3e-08 33.5 28.2 1.3e-07 30.2 10.9 2.1 1 1 1 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE39469.1 - 1.2e-06 27.3 34.3 6.7e-05 21.6 10.5 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2417 PF10329.4 EFE39470.1 - 0.0043 16.4 0.2 0.007 15.8 0.1 1.4 1 0 0 1 1 1 1 Region of unknown function (DUF2417) DUF2207 PF09972.4 EFE39470.1 - 0.023 13.2 0.0 0.027 13.0 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3357 PF11837.3 EFE39470.1 - 1.9 8.3 4.0 10 6.0 1.7 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF3357) Evr1_Alr PF04777.8 EFE39471.1 - 6.1e-12 45.2 0.3 1.1e-11 44.5 0.2 1.4 1 1 0 1 1 1 1 Erv1 / Alr family R3H PF01424.17 EFE39473.1 - 1.1e-11 44.1 0.1 4.7e-11 42.2 0.1 2.0 2 0 0 2 2 2 1 R3H domain zf-NF-X1 PF01422.12 EFE39473.1 - 0.00028 20.7 31.4 0.00087 19.1 9.1 12.4 12 1 0 12 12 12 5 NF-X1 type zinc finger ARID PF01388.16 EFE39475.1 - 5.2e-17 61.4 0.0 1.5e-16 59.9 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain OmpH PF03938.9 EFE39475.1 - 0.017 15.0 0.0 0.017 15.0 0.0 3.3 2 1 0 3 3 3 0 Outer membrane protein (OmpH-like) Img2 PF05046.9 EFE39476.1 - 2.6e-20 72.4 0.0 4.2e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) eIF3_N PF09440.5 EFE39477.1 - 1.3e-47 161.2 2.2 3.5e-47 159.9 1.5 1.8 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.22 EFE39477.1 - 1e-13 51.5 0.1 3.4e-13 49.8 0.0 2.0 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 EFE39477.1 - 0.0077 16.0 0.0 0.024 14.3 0.0 1.8 1 1 0 1 1 1 1 COP9 signalosome, subunit CSN8 DUF445 PF04286.7 EFE39477.1 - 3.5 7.0 7.0 1.6 8.1 1.6 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF445) ArsA_ATPase PF02374.10 EFE39478.1 - 3.4e-111 371.1 0.0 5.1e-111 370.5 0.0 1.2 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 EFE39478.1 - 2.1e-16 59.9 0.1 4.3e-16 58.8 0.1 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EFE39478.1 - 1.3e-07 31.6 0.0 3.7e-05 23.6 0.0 3.0 3 1 0 3 3 3 1 AAA domain Fer4_NifH PF00142.13 EFE39478.1 - 1.1e-05 24.8 0.0 2.2e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 EFE39478.1 - 2.9e-05 23.5 0.2 0.00085 18.8 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain MipZ PF09140.6 EFE39478.1 - 0.035 13.1 0.1 0.093 11.7 0.0 1.7 2 0 0 2 2 2 0 ATPase MipZ YhjQ PF06564.7 EFE39478.1 - 0.05 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 YhjQ protein NB-ARC PF00931.17 EFE39478.1 - 0.072 11.9 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.11 EFE39478.1 - 0.072 12.3 0.0 0.17 11.0 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.1 EFE39478.1 - 0.085 12.2 0.2 0.25 10.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EFE39478.1 - 0.11 11.8 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein APS_kinase PF01583.15 EFE39478.1 - 0.16 11.6 0.2 7.4 6.2 0.0 2.9 3 0 0 3 3 3 0 Adenylylsulphate kinase NAD_binding_6 PF08030.7 EFE39479.1 - 2.7e-17 63.1 0.0 4e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EFE39479.1 - 1.5e-14 54.1 13.4 2.7e-14 53.3 9.3 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EFE39479.1 - 7.6e-09 35.3 0.0 0.0014 18.5 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.16 EFE39479.1 - 0.014 15.9 0.0 1.8 9.1 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Transthyretin PF00576.16 EFE39480.1 - 3.3e-18 65.5 0.0 2.5e-10 40.2 0.0 2.2 2 0 0 2 2 2 2 HIUase/Transthyretin family Aft1_HRA PF11786.3 EFE39481.1 - 6.1e-22 77.6 12.6 6.1e-22 77.6 8.7 3.1 2 0 0 2 2 2 1 Aft1 HRA domain Aft1_HRR PF11787.3 EFE39481.1 - 1.1e-19 71.2 2.8 1.1e-19 71.2 2.0 4.1 3 1 1 4 4 4 1 Aft1 HRR domain Aft1_OSA PF11785.3 EFE39481.1 - 5.3e-11 42.8 3.4 5.3e-11 42.8 2.4 2.9 3 0 0 3 3 3 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.16 EFE39481.1 - 1.2e-08 34.7 10.4 2.1e-08 34.0 7.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFE39481.1 - 0.00043 20.0 8.9 0.00088 19.0 6.1 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EFE39481.1 - 0.061 13.6 4.3 0.13 12.5 3.0 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor HeLo PF14479.1 EFE39481.1 - 2.7 7.6 5.8 4.9 6.8 4.0 1.4 1 1 0 1 1 1 0 Prion-inhibition and propagation PARP PF00644.15 EFE39482.1 - 8.7e-12 44.8 0.2 1.9e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.21 EFE39482.1 - 5e-08 32.4 0.0 1.1e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EFE39482.1 - 0.0071 16.2 0.1 0.024 14.5 0.0 1.9 2 0 0 2 2 2 1 RWD domain Prok-E2_B PF14461.1 EFE39482.1 - 0.052 13.3 0.1 0.42 10.3 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic E2 family B COG7 PF10191.4 EFE39483.1 - 0.033 12.1 0.0 0.085 10.7 0.0 1.6 2 0 0 2 2 2 0 Golgi complex component 7 (COG7) RNA_pol_Rpb4 PF03874.11 EFE39484.1 - 9e-08 32.1 0.4 0.0035 17.3 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase Rpb4 Nop PF01798.13 EFE39485.1 - 2.5e-54 182.6 0.5 5.7e-54 181.5 0.4 1.7 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EFE39485.1 - 3.3e-27 94.0 0.1 6.2e-27 93.1 0.1 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 EFE39485.1 - 2.8e-18 65.8 3.0 9.6e-12 44.8 0.3 3.9 4 0 0 4 4 4 2 NOP5NT (NUC127) domain PA26 PF04636.8 EFE39485.1 - 6.2 5.4 12.1 3 6.4 6.4 1.9 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) vATP-synt_AC39 PF01992.11 EFE39486.1 - 7.7e-84 281.6 0.0 1e-83 281.2 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Pribosyltran_N PF13793.1 EFE39487.1 - 1e-32 112.3 0.0 3.2e-32 110.6 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 EFE39487.1 - 4.8e-31 107.9 1.4 1.2e-28 100.0 1.0 2.4 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 EFE39487.1 - 7.5e-10 38.6 0.0 2e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EFE39487.1 - 0.0017 17.5 0.0 0.0028 16.8 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase ubiquitin PF00240.18 EFE39488.1 - 0.00089 18.6 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family DUF1777 PF08648.7 EFE39488.1 - 0.0011 18.7 43.8 0.0014 18.3 30.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) YukD PF08817.5 EFE39488.1 - 0.066 13.7 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD MIP-T3 PF10243.4 EFE39488.1 - 9 4.6 23.8 12 4.2 16.5 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PseudoU_synth_1 PF01416.15 EFE39489.1 - 2.3e-29 101.8 0.0 3.6e-22 78.7 0.0 2.9 2 1 0 2 2 2 2 tRNA pseudouridine synthase Amidoligase_2 PF12224.3 EFE39490.1 - 2.8e-08 33.6 0.0 1e-06 28.5 0.0 2.0 1 1 0 1 1 1 1 Putative amidoligase enzyme TypeIII_RM_meth PF12564.3 EFE39490.1 - 0.54 10.2 2.5 9.4 6.2 0.0 2.6 3 0 0 3 3 3 0 Type III restriction/modification enzyme methylation subunit Ribosomal_S2 PF00318.15 EFE39491.1 - 1.5e-42 145.2 0.0 1.5e-21 76.5 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Ribosomal_S15 PF00312.17 EFE39492.1 - 1.9e-15 56.3 1.2 5.9e-15 54.8 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S15 DEAD PF00270.24 EFE39494.1 - 6.8e-31 107.0 0.0 5.3e-30 104.1 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EFE39494.1 - 8e-20 70.1 0.0 1.6e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EFE39494.1 - 2.5e-19 68.9 0.0 6.9e-19 67.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EFE39494.1 - 0.073 13.2 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Kelch_4 PF13418.1 EFE39495.1 - 9.3e-17 60.5 18.0 7.3e-06 25.6 0.0 5.7 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.1 EFE39495.1 - 3.3e-07 30.2 10.3 0.0043 17.1 0.0 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 EFE39495.1 - 1e-06 28.5 6.4 0.66 9.9 0.1 4.9 5 0 0 5 5 5 3 Kelch motif LCM PF04072.9 EFE39495.1 - 0.11 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase Kelch_2 PF07646.10 EFE39495.1 - 0.17 11.7 8.2 3.5 7.5 0.4 4.1 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.27 EFE39496.1 - 4.6e-09 35.8 1.5 8.2e-05 22.3 0.0 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Hira PF07569.6 EFE39496.1 - 0.032 13.4 0.1 0.13 11.4 0.0 1.9 2 0 0 2 2 2 0 TUP1-like enhancer of split Apc4_WD40 PF12894.2 EFE39496.1 - 0.041 13.3 0.0 5.4 6.6 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.9 EFE39496.1 - 0.19 10.4 0.0 15 4.2 0.0 2.3 2 0 0 2 2 2 0 Coatomer WD associated region MFS_1 PF07690.11 EFE39497.1 - 3.7e-23 81.8 45.5 1.1e-18 67.0 17.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2914 PF11141.3 EFE39498.1 - 0.12 11.8 0.6 10 5.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2914) Met_10 PF02475.11 EFE39499.1 - 0.00014 21.5 0.1 0.00037 20.1 0.0 1.8 2 1 0 2 2 2 1 Met-10+ like-protein EF-hand_6 PF13405.1 EFE39500.1 - 9.7e-09 34.4 0.5 0.00035 20.2 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 EFE39500.1 - 0.00042 20.3 1.2 0.00074 19.6 0.2 2.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 EFE39500.1 - 0.021 14.1 0.0 0.83 9.1 0.0 2.4 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.1 EFE39500.1 - 0.029 13.9 0.0 1.1 8.9 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain pair OB_NTP_bind PF07717.11 EFE39502.1 - 4.6e-25 87.6 0.0 1.1e-24 86.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFE39502.1 - 8.6e-24 83.5 0.1 2.6e-23 81.9 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE39502.1 - 2.6e-10 40.0 0.0 5.6e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE39502.1 - 8.3e-07 28.6 0.1 1.6e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFE39502.1 - 1.7e-05 24.9 0.2 6.9e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 EFE39502.1 - 0.00036 20.0 0.1 0.0009 18.7 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ResIII PF04851.10 EFE39502.1 - 0.0018 18.1 0.0 0.69 9.7 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 EFE39502.1 - 0.002 17.8 0.1 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain T2SE PF00437.15 EFE39502.1 - 0.02 13.7 0.0 0.041 12.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 EFE39502.1 - 0.032 13.8 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EFE39502.1 - 0.14 12.4 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain PRMT5 PF05185.11 EFE39503.1 - 6.6e-167 555.9 0.0 8.2e-167 555.6 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase GDPD PF03009.12 EFE39504.1 - 6.9e-43 146.9 0.0 5.7e-42 143.9 0.0 2.4 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.2 EFE39504.1 - 4.8e-31 106.9 2.2 7.5e-13 48.6 0.6 3.9 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE39504.1 - 1.7e-27 95.3 1.1 8.7e-09 35.6 0.1 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 EFE39504.1 - 2.4e-26 90.1 2.9 8.7e-07 28.4 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat SPX PF03105.14 EFE39504.1 - 1.4e-22 80.8 5.3 3.4e-11 43.4 2.1 3.0 2 1 0 2 2 2 2 SPX domain Ank_5 PF13857.1 EFE39504.1 - 1.5e-18 66.3 0.4 7.5e-06 26.0 0.1 4.8 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE39504.1 - 3.9e-15 54.4 1.5 0.003 17.6 0.0 6.1 5 0 0 5 5 5 4 Ankyrin repeat TAT_signal PF10518.4 EFE39504.1 - 0.13 12.2 0.2 2.7 8.2 0.1 2.5 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence Abhydrolase_3 PF07859.8 EFE39505.1 - 3.1e-59 200.0 0.1 4.1e-59 199.6 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFE39505.1 - 2.3e-07 30.2 0.0 6.7e-05 22.2 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFE39505.1 - 9.7e-05 22.3 2.2 0.00015 21.7 1.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 EFE39505.1 - 0.001 17.9 0.3 0.0028 16.4 0.2 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EFE39505.1 - 0.0031 17.2 0.0 0.0045 16.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 EFE39505.1 - 0.021 14.0 0.1 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase Lyase_1 PF00206.15 EFE39506.1 - 8.1e-107 357.0 0.0 1.2e-106 356.4 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 EFE39506.1 - 1.6e-22 79.3 0.0 3.5e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus DUF4115 PF13464.1 EFE39507.1 - 0.02 14.5 0.0 0.053 13.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4115) Acetyltransf_7 PF13508.1 EFE39508.1 - 5.2e-10 39.3 0.1 7.9e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE39508.1 - 3.1e-06 27.1 0.3 8.6e-06 25.7 0.2 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 EFE39508.1 - 0.068 13.1 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ribosomal_S30 PF04758.9 EFE39509.1 - 3e-27 94.1 9.3 3.7e-27 93.8 6.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S30 DUF3408 PF11888.3 EFE39509.1 - 0.084 12.8 0.2 0.093 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Ribosomal_L24e PF01246.15 EFE39510.1 - 3.9e-31 106.7 0.3 3.9e-31 106.7 0.2 1.9 2 1 0 2 2 2 1 Ribosomal protein L24e EVC2_like PF12297.3 EFE39510.1 - 0.12 10.9 3.1 0.15 10.7 2.2 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein WD40 PF00400.27 EFE39511.1 - 1.6e-14 53.1 11.1 9.4e-05 22.1 0.0 5.9 5 0 0 5 5 5 3 WD domain, G-beta repeat RWD PF05773.17 EFE39511.1 - 0.00063 19.6 0.0 0.0019 18.1 0.0 1.7 1 0 0 1 1 1 1 RWD domain zf-C3HC4_2 PF13923.1 EFE39511.1 - 0.034 14.1 12.7 0.095 12.7 8.8 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) 4HBT PF03061.17 EFE39512.1 - 4.7e-06 26.6 0.0 6.8e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.1 EFE39512.1 - 0.014 15.3 0.0 0.021 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) UCH PF00443.24 EFE39513.1 - 5.9e-55 186.2 1.3 7.6e-55 185.8 0.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE39513.1 - 2e-16 60.3 7.4 8.6e-16 58.2 5.1 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 EFE39513.1 - 1.9e-11 43.2 0.0 4.2e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 EFE39513.1 - 0.062 13.5 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-like domain RILP PF11461.3 EFE39513.1 - 0.17 12.0 0.1 0.17 12.0 0.0 3.4 3 1 0 3 3 3 0 Rab interacting lysosomal protein ARPC4 PF05856.7 EFE39514.1 - 6.7e-69 230.6 3.3 8e-69 230.3 2.3 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) TYW3 PF02676.9 EFE39516.1 - 4.3e-66 221.9 0.0 5.7e-66 221.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 DUF2461 PF09365.5 EFE39517.1 - 2.5e-17 62.9 0.8 2.5e-17 62.9 0.5 1.6 2 0 0 2 2 2 1 Conserved hypothetical protein (DUF2461) FadA PF09403.5 EFE39517.1 - 2.6 8.0 7.5 0.51 10.3 0.2 2.2 2 0 0 2 2 2 0 Adhesion protein FadA Polysacc_deac_1 PF01522.16 EFE39521.1 - 4.9e-19 68.1 0.2 2.1e-17 62.8 0.1 2.3 1 1 0 1 1 1 1 Polysaccharide deacetylase KAR9 PF08580.5 EFE39521.1 - 0.66 8.1 5.7 0.79 7.9 3.9 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Mito_carr PF00153.22 EFE39522.1 - 1.7e-50 168.7 0.3 1.2e-19 69.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein EpsG PF14897.1 EFE39522.1 - 0.083 11.8 0.1 3.1 6.6 0.0 2.1 2 0 0 2 2 2 0 EpsG family WD40 PF00400.27 EFE39523.1 - 2.6e-24 84.1 12.2 5.4e-10 38.7 0.2 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF2A PF08662.6 EFE39523.1 - 0.0014 18.3 0.0 0.17 11.5 0.0 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 EFE39523.1 - 0.035 12.8 5.3 0.24 10.0 0.3 2.8 2 1 1 3 3 3 0 Nup133 N terminal like Fork_head PF00250.13 EFE39524.1 - 1.1e-14 54.1 0.2 2.1e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 Fork head domain Cactin_mid PF10312.4 EFE39525.1 - 9.5e-67 223.9 5.1 1.7e-66 223.1 3.6 1.4 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.4 EFE39525.1 - 8.5e-54 180.4 2.9 1.6e-53 179.6 2.0 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein XLF PF09302.6 EFE39526.1 - 3.2e-30 105.1 0.1 8.6e-30 103.7 0.0 1.8 2 0 0 2 2 2 1 XLF (XRCC4-like factor) Ribosomal_L34e PF01199.13 EFE39527.1 - 5.6e-24 84.1 1.3 1e-13 51.2 0.1 2.3 1 1 1 2 2 2 2 Ribosomal protein L34e DUF1428 PF07237.6 EFE39527.1 - 0.051 13.4 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) FhuF_C PF11575.3 EFE39527.1 - 0.36 10.4 2.5 6.8 6.4 0.2 2.5 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain PROCN PF08083.6 EFE39528.1 - 1.6e-223 741.5 8.7 2.7e-223 740.8 6.0 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 EFE39528.1 - 1e-125 417.6 2.9 1.7e-125 416.9 2.0 1.3 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 EFE39528.1 - 5.9e-100 331.2 0.5 1.9e-63 212.6 0.2 2.6 2 0 0 2 2 2 2 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 EFE39528.1 - 1.7e-77 258.2 3.2 1.8e-77 258.1 1.1 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 EFE39528.1 - 1.8e-66 221.8 0.2 3.9e-66 220.7 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 Hom_end_hint PF05203.11 EFE39528.1 - 1.7e-53 181.5 2.2 9.7e-53 179.0 0.0 2.5 2 0 0 2 2 2 1 Hom_end-associated Hint RRM_4 PF10598.4 EFE39528.1 - 4.9e-45 151.3 0.2 1.4e-44 149.9 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.6 EFE39528.1 - 9.5e-34 115.8 1.0 1.9e-33 114.8 0.1 2.0 2 0 0 2 2 2 1 PROCT (NUC072) domain Hom_end PF05204.9 EFE39528.1 - 0.0059 16.5 0.0 0.02 14.8 0.0 1.9 1 0 0 1 1 1 1 Homing endonuclease DUF3753 PF12575.3 EFE39528.1 - 0.15 11.9 0.0 0.44 10.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) OCD_Mu_crystall PF02423.10 EFE39528.1 - 0.39 9.4 0.7 0.65 8.7 0.5 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family HATPase_c_3 PF13589.1 EFE39529.1 - 0.048 13.3 0.2 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Choline_kinase PF01633.15 EFE39529.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase CTP_synth_N PF06418.9 EFE39530.1 - 8.2e-64 215.3 0.0 1.1e-63 214.9 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 EFE39530.1 - 3.5e-54 183.2 0.0 5.2e-54 182.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EFE39530.1 - 4.6e-07 29.5 0.0 1.3e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 Myb_DNA-bind_6 PF13921.1 EFE39533.1 - 5.8e-08 32.7 0.0 1.1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFE39533.1 - 0.00011 22.1 0.0 0.00019 21.4 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_60s PF00428.14 EFE39535.1 - 7.3 7.0 10.0 9.2 6.7 6.9 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF4407 PF14362.1 EFE39536.1 - 0.98 8.3 12.7 3.1 6.6 8.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) p450 PF00067.17 EFE39537.1 - 7.7e-54 182.9 0.7 9.3e-25 87.0 0.3 3.1 3 0 0 3 3 3 3 Cytochrome P450 FMO-like PF00743.14 EFE39538.1 - 7.1e-87 291.7 0.0 8.7e-87 291.5 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFE39538.1 - 4.2e-17 62.8 0.0 1.1e-16 61.4 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE39538.1 - 5.7e-10 38.6 0.1 2.9e-08 33.0 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EFE39538.1 - 0.0064 16.2 0.1 5.3 6.8 0.0 2.7 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFE39538.1 - 0.048 13.5 0.0 0.11 12.3 0.0 1.3 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE39538.1 - 0.055 13.8 0.1 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase LeuA_dimer PF08502.5 EFE39538.1 - 0.095 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 LeuA allosteric (dimerisation) domain Fork_head PF00250.13 EFE39541.1 - 2.1e-36 123.8 2.1 4.6e-36 122.7 1.5 1.5 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 EFE39541.1 - 9.8e-09 35.2 0.0 7.2e-08 32.4 0.0 2.2 2 0 0 2 2 2 1 FHA domain FAD_binding_3 PF01494.14 EFE39543.1 - 5.5e-21 75.0 0.0 8e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFE39543.1 - 2.8e-07 29.7 2.3 3.7e-05 22.7 1.6 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE39543.1 - 1.6e-06 28.0 2.0 4.6e-06 26.5 1.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFE39543.1 - 1.3e-05 24.2 7.1 1.8e-05 23.7 4.2 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 EFE39543.1 - 5.7e-05 23.0 2.1 0.00035 20.5 1.5 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE39543.1 - 0.00052 18.5 0.7 0.0045 15.4 1.7 1.6 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.17 EFE39543.1 - 0.0013 17.6 2.9 0.0019 17.1 2.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.22 EFE39543.1 - 0.0015 18.9 2.0 0.023 15.0 1.7 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 EFE39543.1 - 0.0022 16.8 0.0 0.0036 16.1 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase Thi4 PF01946.12 EFE39543.1 - 0.0028 16.7 0.9 0.0046 16.0 0.6 1.2 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.2 EFE39543.1 - 0.0051 15.9 5.4 0.0081 15.2 3.7 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 EFE39543.1 - 0.021 13.4 1.6 0.59 8.6 0.7 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.1 EFE39543.1 - 0.026 14.5 0.4 0.078 13.0 0.3 1.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EFE39543.1 - 0.048 13.3 3.5 0.081 12.5 2.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amino_oxidase PF01593.19 EFE39543.1 - 0.072 12.1 1.1 0.25 10.3 0.5 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Rossmann-like PF10727.4 EFE39543.1 - 0.091 12.4 0.1 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain UDPG_MGDP_dh_N PF03721.9 EFE39543.1 - 0.16 11.3 1.1 0.31 10.4 0.8 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.16 EFE39543.1 - 0.21 11.1 0.9 0.32 10.5 0.7 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.18 EFE39543.1 - 0.24 11.1 1.0 0.38 10.4 0.7 1.2 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Hexapep PF00132.19 EFE39544.1 - 4.9e-14 51.0 5.2 4.4e-08 32.2 0.5 3.5 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.3 EFE39544.1 - 6.6e-12 45.2 0.0 1.4e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Maltose acetyltransferase Zn_clus PF00172.13 EFE39544.1 - 2.9e-10 39.8 8.8 5e-10 39.1 6.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexapep_2 PF14602.1 EFE39544.1 - 1.1e-08 34.5 4.8 2.1e-06 27.1 0.4 2.7 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase ALAD PF00490.16 EFE39545.1 - 4.3e-113 377.4 0.0 4.8e-113 377.3 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase p450 PF00067.17 EFE39546.1 - 2.5e-53 181.2 0.0 1.4e-43 149.1 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 Shugoshin_N PF07558.6 EFE39546.1 - 1.3e-15 56.8 1.4 2.9e-15 55.6 1.0 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.6 EFE39546.1 - 1.3e-07 30.9 9.0 1.3e-07 30.9 6.2 2.9 2 0 0 2 2 2 1 Shugoshin C terminus DAO PF01266.19 EFE39547.1 - 7.4e-17 61.2 0.4 1.5e-16 60.2 0.2 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 EFE39547.1 - 7.5e-07 28.5 0.7 9.7e-07 28.2 0.5 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFE39547.1 - 4.3e-05 22.5 0.9 7e-05 21.8 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFE39547.1 - 0.00021 21.2 0.1 0.00036 20.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EFE39547.1 - 0.00024 20.8 0.1 0.00034 20.3 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 EFE39547.1 - 0.0016 17.4 0.1 0.0023 16.8 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 EFE39547.1 - 0.0016 18.3 0.2 0.0031 17.4 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFE39547.1 - 0.0021 16.6 0.3 0.0032 15.9 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 EFE39547.1 - 0.01 16.2 0.1 0.01 16.2 0.1 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_10 PF13460.1 EFE39547.1 - 0.014 15.3 0.2 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 NADH(P)-binding Lycopene_cycl PF05834.7 EFE39547.1 - 0.014 14.2 0.1 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.14 EFE39547.1 - 0.045 12.7 0.2 0.061 12.3 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain DUF3115 PF11312.3 EFE39547.1 - 0.046 12.5 0.0 0.052 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3115) Thi4 PF01946.12 EFE39547.1 - 0.093 11.8 0.2 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.11 EFE39547.1 - 0.13 11.7 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TAT_signal PF10518.4 EFE39547.1 - 0.21 11.6 0.2 0.21 11.6 0.2 2.3 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence DAO PF01266.19 EFE39548.1 - 9.1e-29 100.4 0.0 1.3e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase SAM_2 PF07647.12 EFE39550.1 - 3.7e-10 39.4 0.1 6.8e-10 38.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EFE39550.1 - 1.1e-07 31.9 0.2 2.8e-07 30.6 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.24 EFE39550.1 - 2.2e-05 24.5 0.1 5.1e-05 23.4 0.1 1.7 1 0 0 1 1 1 1 PH domain Ste50p-SAM PF09235.5 EFE39550.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Ste50p, sterile alpha motif SAM_PNT PF02198.11 EFE39550.1 - 0.016 14.9 0.1 0.045 13.5 0.1 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain PH_6 PF15406.1 EFE39550.1 - 0.063 13.3 0.1 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain UQ_con PF00179.21 EFE39552.1 - 1.4e-42 144.4 0.0 1.8e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.5 EFE39552.1 - 3.3e-06 26.6 0.0 6.9e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.1 EFE39552.1 - 5.7e-05 22.8 0.0 9.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFE39552.1 - 0.053 13.4 0.0 0.094 12.6 0.0 1.4 1 1 0 1 1 1 0 RWD domain APH PF01636.18 EFE39553.1 - 1.1e-10 41.6 0.0 1.2e-09 38.2 0.0 2.7 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.20 EFE39553.1 - 0.045 12.8 0.0 0.25 10.4 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39553.1 - 0.13 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase AAA PF00004.24 EFE39554.1 - 6.2e-41 139.6 0.0 1.2e-40 138.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE39554.1 - 3.1e-07 30.5 0.3 0.00014 22.0 0.2 2.6 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EFE39554.1 - 1.1e-05 25.4 0.0 2.2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 EFE39554.1 - 4e-05 23.3 0.0 0.00011 21.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 EFE39554.1 - 5.1e-05 22.3 0.0 9.1e-05 21.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 EFE39554.1 - 0.0007 19.5 0.3 0.0027 17.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFE39554.1 - 0.00087 19.3 0.1 0.0058 16.6 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 EFE39554.1 - 0.0011 18.0 0.0 0.002 17.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFE39554.1 - 0.0014 18.3 0.4 0.0031 17.2 0.3 1.5 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 EFE39554.1 - 0.0041 16.5 0.0 0.0087 15.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 EFE39554.1 - 0.007 15.4 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin NACHT PF05729.7 EFE39554.1 - 0.01 15.5 0.5 0.71 9.5 0.1 3.0 2 1 0 3 3 3 1 NACHT domain AAA_14 PF13173.1 EFE39554.1 - 0.015 15.2 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFE39554.1 - 0.018 15.8 0.3 0.053 14.3 0.2 2.0 1 1 0 1 1 1 0 AAA domain KaiC PF06745.8 EFE39554.1 - 0.022 13.9 0.4 0.29 10.2 0.1 2.2 1 1 0 2 2 2 0 KaiC TIP49 PF06068.8 EFE39554.1 - 0.026 13.2 1.7 0.032 12.9 0.1 1.9 2 1 0 2 2 2 0 TIP49 C-terminus AAA_3 PF07726.6 EFE39554.1 - 0.031 13.8 0.0 0.073 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EFE39554.1 - 0.041 14.1 0.0 0.088 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFE39554.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 EFE39554.1 - 0.061 12.1 0.0 0.088 11.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.11 EFE39554.1 - 0.063 12.5 1.4 0.45 9.7 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.4 EFE39554.1 - 0.073 12.0 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.17 EFE39554.1 - 0.081 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.16 EFE39554.1 - 0.12 11.5 0.1 0.24 10.5 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 EFE39554.1 - 0.14 12.4 0.6 1.1 9.5 0.4 2.5 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.1 EFE39554.1 - 0.32 10.3 5.4 0.7 9.2 0.3 2.7 2 1 0 3 3 3 0 AAA domain AAA_24 PF13479.1 EFE39554.1 - 0.33 10.5 1.9 0.35 10.4 0.2 1.8 2 0 0 2 2 2 0 AAA domain WD40 PF00400.27 EFE39555.1 - 5.7e-20 70.3 15.3 2.4e-06 27.2 0.3 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EFE39555.1 - 0.11 12.1 0.0 2.2 7.9 0.0 2.6 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Mg_trans_NIPA PF05653.9 EFE39556.1 - 1.1e-65 221.6 10.0 7.7e-63 212.2 5.6 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 EFE39556.1 - 1.1e-05 25.5 0.8 1.1e-05 25.5 0.5 3.3 2 1 0 2 2 2 1 Multidrug resistance efflux transporter TctB PF07331.6 EFE39556.1 - 0.00031 20.4 5.2 0.97 9.0 4.6 3.2 3 0 0 3 3 3 2 Tripartite tricarboxylate transporter TctB family EamA PF00892.15 EFE39556.1 - 0.00048 20.1 1.2 0.00048 20.1 0.8 3.8 3 1 1 4 4 4 1 EamA-like transporter family DUF914 PF06027.7 EFE39556.1 - 0.0013 17.6 4.0 0.0022 16.8 2.4 1.5 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) DoxX_2 PF13564.1 EFE39556.1 - 0.11 12.4 8.7 2.2 8.2 0.4 2.8 2 1 1 3 3 3 0 DoxX-like family Med30 PF11315.3 EFE39557.1 - 0.00092 19.3 0.8 0.46 10.6 0.2 2.5 2 0 0 2 2 2 2 Mediator complex subunit 30 DivIC PF04977.10 EFE39557.1 - 0.014 14.8 2.4 0.014 14.8 1.6 2.8 3 0 0 3 3 3 0 Septum formation initiator HALZ PF02183.13 EFE39557.1 - 0.12 12.0 6.1 3.8 7.2 0.4 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper bZIP_1 PF00170.16 EFE39557.1 - 0.58 10.1 9.6 1.5 8.8 3.0 2.6 2 0 0 2 2 2 0 bZIP transcription factor RRM_1 PF00076.17 EFE39558.1 - 3.5e-35 119.4 0.0 4.4e-17 61.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE39558.1 - 3.4e-18 65.3 0.0 1.1e-09 38.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39558.1 - 4.1e-15 55.3 0.0 1.5e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFE39558.1 - 7.1e-06 25.8 0.1 5.6e-05 22.9 0.0 2.2 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.1 EFE39558.1 - 0.00038 20.1 0.0 0.005 16.5 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Statherin PF03875.8 EFE39558.1 - 1.3 8.9 8.9 4 7.3 6.2 1.9 1 0 0 1 1 1 0 Statherin LAM_C PF12544.3 EFE39561.1 - 0.13 12.2 0.2 0.52 10.3 0.0 1.9 2 0 0 2 2 2 0 Lysine-2,3-aminomutase His_Phos_1 PF00300.17 EFE39563.1 - 2e-19 70.2 0.0 2.7e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Peptidase_M28 PF04389.12 EFE39564.1 - 2.1e-28 99.2 0.2 3.2e-28 98.6 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EFE39564.1 - 0.071 12.6 1.0 0.093 12.2 0.1 1.7 2 0 0 2 2 2 0 Peptidase family M20/M25/M40 GH3 PF03321.8 EFE39565.1 - 0.00021 19.9 0.0 0.00026 19.6 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter DnaJ PF00226.26 EFE39566.1 - 3e-21 74.9 1.2 5.9e-21 73.9 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain PRP38_assoc PF12871.2 EFE39566.1 - 0.00074 20.0 35.0 0.00074 20.0 24.3 5.5 4 1 1 5 5 5 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF1777 PF08648.7 EFE39566.1 - 0.00099 18.8 37.1 0.00099 18.8 25.7 3.7 4 1 1 5 5 5 1 Protein of unknown function (DUF1777) APH PF01636.18 EFE39570.1 - 4.4e-13 49.5 0.0 3.1e-12 46.7 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family PPR PF01535.15 EFE39570.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 PPR repeat Avl9 PF09794.4 EFE39571.1 - 3.8e-40 137.5 0.0 5.4e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.5 EFE39571.1 - 0.00074 19.2 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis APC_CDC26 PF10471.4 EFE39571.1 - 0.03 15.0 2.9 0.03 15.0 2.0 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex APC subunit 1 Mit_KHE1 PF10173.4 EFE39571.1 - 0.25 11.1 1.0 35 4.1 0.1 2.9 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related Cullin PF00888.17 EFE39572.1 - 8.7e-196 651.9 7.0 1.4e-195 651.3 4.8 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 EFE39572.1 - 8.3e-28 96.0 3.3 8.3e-28 96.0 2.3 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain Abi_C PF14355.1 EFE39572.1 - 0.089 12.7 0.0 0.47 10.4 0.0 2.2 2 0 0 2 2 2 0 Abortive infection C-terminus WGG PF10273.4 EFE39572.1 - 0.097 12.7 0.2 24 5.1 0.0 2.9 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 Kinase-PPPase PF03618.9 EFE39572.1 - 0.59 9.5 7.7 5.2 6.4 0.3 2.3 2 0 0 2 2 2 0 Kinase/pyrophosphorylase Cupin_1 PF00190.17 EFE39573.1 - 3.2e-10 39.6 0.1 4.9e-10 39.0 0.1 1.4 1 1 0 1 1 1 1 Cupin Cupin_2 PF07883.6 EFE39573.1 - 1.8e-07 30.5 0.1 2.9e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.2 EFE39573.1 - 0.00021 20.9 0.2 0.00026 20.6 0.1 1.1 1 0 0 1 1 1 1 Cupin ARD PF03079.9 EFE39573.1 - 0.00055 19.9 0.0 0.00075 19.4 0.0 1.2 1 0 0 1 1 1 1 ARD/ARD' family AraC_binding PF02311.14 EFE39573.1 - 0.003 17.2 0.0 0.0038 16.9 0.0 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain FdtA PF05523.6 EFE39573.1 - 0.0096 15.4 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 1 WxcM-like, C-terminal AMNp_N PF10423.4 EFE39573.1 - 0.06 12.9 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus GPI PF06560.6 EFE39573.1 - 0.073 12.0 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) MARVEL PF01284.18 EFE39574.1 - 0.0034 17.2 2.4 0.005 16.6 1.7 1.2 1 0 0 1 1 1 1 Membrane-associating domain Ilm1 PF10311.4 EFE39574.1 - 0.051 13.0 1.7 0.14 11.6 1.2 1.9 1 1 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 DUF1418 PF07214.7 EFE39574.1 - 0.054 13.1 2.3 0.26 10.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DUF202 PF02656.10 EFE39574.1 - 0.085 13.0 2.5 2.8 8.2 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) HSP70 PF00012.15 EFE39576.1 - 1.2e-165 551.8 0.1 1.6e-165 551.4 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFE39576.1 - 3.6e-11 42.2 0.3 7.6e-11 41.1 0.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 EFE39576.1 - 6.6e-05 22.7 0.6 0.036 13.9 0.0 3.5 3 1 0 3 3 3 1 Cell division protein FtsA Ketoacyl-synt_C PF02801.17 EFE39576.1 - 0.056 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain NAM-associated PF14303.1 EFE39576.1 - 2.2 8.5 9.3 4.9 7.4 6.2 1.8 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Thiolase_N PF00108.18 EFE39577.1 - 7.7e-71 238.1 0.2 1.5e-70 237.1 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFE39577.1 - 2.7e-41 139.8 0.6 5.4e-41 138.8 0.4 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.5 EFE39577.1 - 0.089 12.4 0.2 0.4 10.3 0.0 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III WLM PF08325.5 EFE39578.1 - 4.9e-45 153.6 0.0 6.9e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.12 EFE39578.1 - 0.0001 22.1 0.1 0.00043 20.1 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function DUF45 SprT-like PF10263.4 EFE39578.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 SprT-like family LicD PF04991.8 EFE39579.1 - 3.6e-36 125.1 2.6 7.8e-35 120.8 1.8 2.0 1 1 0 1 1 1 1 LicD family DASH_Ask1 PF08655.5 EFE39581.1 - 6.3e-32 109.2 0.3 1.2e-31 108.3 0.2 1.5 1 0 0 1 1 1 1 DASH complex subunit Ask1 Abhydrolase_6 PF12697.2 EFE39582.1 - 2.7e-31 109.2 0.1 3.1e-31 109.0 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE39582.1 - 2e-16 60.0 0.0 1.4e-15 57.3 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE39582.1 - 1.2e-14 54.4 0.0 7.8e-14 51.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFE39582.1 - 4.1e-06 26.5 0.0 8.7e-06 25.5 0.0 1.5 2 0 0 2 2 2 1 Putative lysophospholipase Ndr PF03096.9 EFE39582.1 - 6.3e-06 24.8 0.0 7.9e-06 24.5 0.0 1.1 1 0 0 1 1 1 1 Ndr family PGAP1 PF07819.8 EFE39582.1 - 0.00021 20.9 0.0 0.00029 20.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.15 EFE39582.1 - 0.0014 18.9 0.0 0.0019 18.4 0.0 1.3 1 1 0 1 1 1 1 Thioesterase domain DUF915 PF06028.6 EFE39582.1 - 0.14 11.1 0.0 8.1 5.4 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) PetM PF08041.6 EFE39582.1 - 0.21 11.1 0.7 0.44 10.0 0.5 1.6 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 DUF4006 PF13179.1 EFE39584.1 - 0.00061 19.2 0.0 0.00077 18.9 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF4006) Amidohydro_1 PF01979.15 EFE39585.1 - 1.3e-10 41.4 3.1 4.2e-10 39.7 2.1 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EFE39585.1 - 4.3e-08 32.8 0.1 2.3e-07 30.5 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 EFE39585.1 - 1.6e-07 30.9 3.7 2.6e-07 30.2 0.5 2.2 1 1 0 2 2 2 1 Amidohydrolase family Amidohydro_4 PF13147.1 EFE39585.1 - 9.4e-06 25.8 3.2 8.3e-05 22.7 2.2 2.3 1 1 0 1 1 1 1 Amidohydrolase tRNA-synt_1c PF00749.16 EFE39586.1 - 3e-95 318.4 0.0 4.2e-95 318.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EFE39586.1 - 2.5e-38 131.4 1.5 3.7e-38 130.9 1.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.1 EFE39586.1 - 0.00046 20.6 0.0 0.0015 18.9 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.14 EFE39586.1 - 0.0096 15.0 0.0 0.033 13.2 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain GST_C PF00043.20 EFE39586.1 - 0.079 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain PspA_IM30 PF04012.7 EFE39587.1 - 0.021 14.1 0.3 0.022 14.1 0.2 1.1 1 0 0 1 1 1 0 PspA/IM30 family TEX13 PF15186.1 EFE39587.1 - 0.064 12.8 0.5 0.071 12.6 0.3 1.1 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family Inhibitor_I29 PF08246.7 EFE39587.1 - 0.14 12.4 3.6 0.18 12.0 2.5 1.2 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) Dot_icm_IcmQ PF09475.5 EFE39587.1 - 0.16 11.1 2.1 0.18 11.0 1.5 1.0 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Glyco_hydro_3 PF00933.16 EFE39588.1 - 2.7e-59 200.6 0.0 4e-59 200.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.19 EFE39588.1 - 6.5e-17 61.3 0.1 5.9e-08 32.6 0.0 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE39588.1 - 4e-13 49.3 0.0 4.8e-06 26.6 0.0 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE39588.1 - 3e-09 37.0 0.0 0.00021 21.3 0.0 2.7 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE39588.1 - 5.3e-07 29.5 0.1 0.0081 16.0 0.0 2.7 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Glyco_hydro_3_C PF01915.17 EFE39588.1 - 1.7e-06 27.7 0.0 3.4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain FR47 PF08445.5 EFE39588.1 - 0.00066 19.3 0.1 0.04 13.6 0.0 2.6 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.1 EFE39588.1 - 0.0043 16.8 0.0 0.99 9.3 0.0 3.3 3 0 0 3 3 3 1 GCN5-related N-acetyl-transferase RVT_3 PF13456.1 EFE39588.1 - 0.016 15.0 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 0 Reverse transcriptase-like DUF3774 PF12609.3 EFE39588.1 - 0.14 13.0 0.1 0.29 12.0 0.0 1.5 1 0 0 1 1 1 0 Wound-induced protein ATP11 PF06644.6 EFE39589.1 - 4e-84 282.2 0.0 4.6e-84 282.0 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein Scytalone_dh PF02982.9 EFE39589.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 Scytalone dehydratase Abhydrolase_5 PF12695.2 EFE39590.1 - 1.3e-19 70.4 0.0 2.3e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE39590.1 - 1.8e-14 54.2 0.0 4.5e-13 49.5 0.0 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE39590.1 - 3.6e-05 23.4 0.0 0.00026 20.6 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.6 EFE39590.1 - 0.00019 21.1 0.0 0.0057 16.3 0.0 2.3 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.8 EFE39590.1 - 0.00031 20.3 0.0 0.00047 19.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 EFE39590.1 - 0.0013 18.0 0.0 0.15 11.2 0.0 2.4 3 0 0 3 3 3 1 Dienelactone hydrolase family AXE1 PF05448.7 EFE39590.1 - 0.0035 15.8 0.1 0.053 12.0 0.0 2.5 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) FSH1 PF03959.8 EFE39590.1 - 0.0037 16.7 0.0 0.016 14.6 0.0 1.8 1 1 0 2 2 2 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.3 EFE39590.1 - 0.0051 16.6 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_2 PF02230.11 EFE39590.1 - 0.012 15.1 0.3 0.51 9.7 0.0 2.5 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase DUF2305 PF10230.4 EFE39590.1 - 0.014 14.8 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) PGAP1 PF07819.8 EFE39590.1 - 0.021 14.3 0.1 0.061 12.9 0.1 1.7 1 1 0 1 1 1 0 PGAP1-like protein DUF818 PF05677.7 EFE39590.1 - 0.021 13.5 0.0 0.03 13.0 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.16 EFE39590.1 - 0.052 12.7 0.0 0.35 10.0 0.0 2.2 1 1 0 1 1 1 0 Prolyl oligopeptidase family Lipase_3 PF01764.20 EFE39590.1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) PNRC PF15365.1 EFE39591.1 - 0.67 10.0 3.6 13 5.8 0.6 2.4 2 1 0 2 2 2 0 Proline-rich nuclear receptor coactivator Luteo_Vpg PF01659.11 EFE39591.1 - 2.3 7.9 6.1 11 5.7 0.3 2.1 2 0 0 2 2 2 0 Luteovirus putative VPg genome linked protein SAP PF02037.22 EFE39592.1 - 4.2e-12 45.2 0.1 9.7e-12 44.0 0.1 1.7 1 0 0 1 1 1 1 SAP domain CCT_2 PF09425.5 EFE39592.1 - 0.17 11.4 6.6 2.9 7.5 0.8 2.7 2 0 0 2 2 2 0 Divergent CCT motif CDC27 PF09507.5 EFE39592.1 - 1.4 8.0 25.8 1.8 7.7 17.9 1.3 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 SSrecog PF03531.9 EFE39593.1 - 1.5e-67 227.1 0.5 5.6e-66 222.0 0.4 2.9 1 1 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 EFE39593.1 - 1e-27 95.9 0.2 3.4e-27 94.2 0.0 1.9 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Rax2 PF12768.2 EFE39594.1 - 2.8e-87 292.5 4.8 1.1e-76 257.7 0.0 5.6 5 2 0 5 5 5 3 Cortical protein marker for cell polarity Reg_prop PF07494.6 EFE39594.1 - 0.023 14.6 3.8 35 4.8 0.0 5.5 6 0 0 6 6 6 0 Two component regulator propeller WD40 PF00400.27 EFE39594.1 - 0.075 12.9 0.3 4.8 7.2 0.0 4.1 4 0 0 4 4 4 0 WD domain, G-beta repeat Kelch_4 PF13418.1 EFE39594.1 - 0.095 12.4 4.3 0.58 9.9 0.1 4.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Fungal_trans_2 PF11951.3 EFE39595.1 - 1.9e-06 26.7 1.2 3.6e-06 25.8 0.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain APH PF01636.18 EFE39596.1 - 1.9e-15 57.2 1.0 4.3e-15 56.1 0.0 2.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family Pyr_redox_3 PF13738.1 EFE39597.1 - 7.7e-26 91.4 0.0 2.3e-22 80.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFE39597.1 - 3e-10 38.9 0.9 4.4e-09 35.0 0.3 2.4 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like DAO PF01266.19 EFE39597.1 - 3.8e-10 39.1 0.0 3.4e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE39597.1 - 2.1e-09 37.2 0.4 6e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFE39597.1 - 1.7e-08 33.7 0.2 6.1e-05 22.1 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EFE39597.1 - 1.9e-07 31.1 0.0 0.0014 18.5 0.0 2.4 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFE39597.1 - 9.2e-06 25.5 0.0 0.035 13.8 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.12 EFE39597.1 - 0.0023 17.0 0.0 0.09 11.8 0.0 2.6 3 0 0 3 3 3 1 Thi4 family GIDA PF01134.17 EFE39597.1 - 0.01 14.7 0.2 0.095 11.5 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Mqo PF06039.10 EFE39597.1 - 0.039 12.1 0.0 3 5.9 0.0 2.3 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.7 EFE39597.1 - 0.072 11.9 0.0 6.1 5.6 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.9 EFE39597.1 - 0.14 10.6 0.2 11 4.3 0.0 2.8 3 0 0 3 3 3 0 HI0933-like protein OGG_N PF07934.7 EFE39598.1 - 1.6e-26 92.5 0.4 3.4e-26 91.5 0.3 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 EFE39598.1 - 6.9e-16 58.4 0.0 1.1e-15 57.7 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EFE39598.1 - 0.00072 19.1 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif RRM_1 PF00076.17 EFE39599.1 - 1.3e-30 104.8 0.2 6.8e-13 48.0 0.0 4.0 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE39599.1 - 5.8e-22 77.4 0.0 1e-05 25.4 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39599.1 - 4e-17 61.8 0.0 4.9e-08 32.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 EFE39600.1 - 1e-11 44.1 10.0 2.2e-05 24.1 2.1 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.1 EFE39600.1 - 9.9e-07 28.3 6.3 0.00039 20.0 1.9 2.3 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 EFE39600.1 - 0.00015 21.3 6.2 0.088 12.4 0.4 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.1 EFE39600.1 - 0.0005 19.6 6.5 0.24 11.0 0.5 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.1 EFE39600.1 - 0.015 14.7 6.4 0.033 13.6 0.2 2.8 1 1 1 2 2 2 0 Zinc knuckle HCO3_cotransp PF00955.16 EFE39601.1 - 1.8e-60 205.1 10.2 1.6e-31 109.6 1.3 2.1 1 1 1 2 2 2 2 HCO3- transporter family BCHF PF07284.6 EFE39601.1 - 0.012 15.5 0.7 0.032 14.0 0.2 2.0 1 1 0 1 1 1 0 2-vinyl bacteriochlorophyllide hydratase (BCHF) DEAD PF00270.24 EFE39602.1 - 6.3e-40 136.4 0.0 1.3e-39 135.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE39602.1 - 9.8e-26 89.4 0.1 1.9e-25 88.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFE39602.1 - 0.00025 19.9 0.0 0.00041 19.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EFE39602.1 - 0.012 15.4 0.0 0.053 13.3 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit CDC45 PF02724.9 EFE39602.1 - 2.7 5.9 4.2 4.2 5.2 2.9 1.2 1 0 0 1 1 1 0 CDC45-like protein tRNA-synt_1c PF00749.16 EFE39606.1 - 4.1e-97 324.6 0.0 5.4e-97 324.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EFE39606.1 - 5.4e-39 133.6 0.1 8.6e-39 132.9 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.1 EFE39606.1 - 6.9e-07 29.6 0.0 2.1e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFE39606.1 - 0.015 15.2 0.0 0.043 13.8 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFE39606.1 - 0.021 14.6 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1793 PF08760.6 EFE39607.1 - 2.4e-71 239.0 0.1 4.3e-71 238.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) Stm1_N PF09598.5 EFE39610.1 - 5.3e-07 30.2 8.5 5.3e-07 30.2 5.9 4.7 3 1 0 3 3 3 2 Stm1 API5 PF05918.6 EFE39610.1 - 7.4 4.9 8.3 13 4.1 5.7 1.4 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Glycos_transf_1 PF00534.15 EFE39613.1 - 1.6e-20 73.2 0.0 2.9e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFE39613.1 - 1.9e-09 37.8 0.0 6.7e-09 36.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EFE39613.1 - 9.9e-05 22.5 0.0 0.00026 21.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3632 PF12311.3 EFE39615.1 - 7.6e-38 130.1 6.7 1.1e-37 129.5 4.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) RNA_pol_Rpb2_6 PF00562.23 EFE39616.1 - 3.3e-119 398.0 0.0 5e-119 397.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EFE39616.1 - 1.1e-56 191.0 0.4 4.7e-56 188.9 0.3 1.9 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 EFE39616.1 - 1.2e-29 103.0 1.8 3e-29 101.8 1.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 EFE39616.1 - 6.4e-27 93.6 0.2 1.6e-26 92.3 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 EFE39616.1 - 6.5e-22 77.1 0.3 2.8e-21 75.0 0.2 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 EFE39616.1 - 1.7e-18 66.1 0.0 4e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 EFE39616.1 - 8.1e-13 48.1 0.2 2.6e-12 46.5 0.2 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 Baculo_Y142 PF04913.7 EFE39616.1 - 0.04 12.2 1.5 0.048 12.0 0.1 1.7 2 0 0 2 2 2 0 Baculovirus Y142 protein PUF PF00806.14 EFE39617.1 - 3.1e-57 186.9 7.9 1.3e-07 30.7 0.0 9.0 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat ORC5_C PF14630.1 EFE39618.1 - 1.4e-78 264.0 0.0 1.8e-78 263.7 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 EFE39618.1 - 1.5e-14 54.4 0.0 6e-14 52.4 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 EFE39618.1 - 8e-07 28.8 0.1 0.014 15.0 0.0 2.5 3 0 0 3 3 2 2 NACHT domain ABC_tran PF00005.22 EFE39618.1 - 0.00036 20.8 0.0 0.00067 19.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 EFE39618.1 - 0.0012 18.9 0.0 0.0035 17.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 EFE39618.1 - 0.0033 16.4 0.0 0.0072 15.3 0.0 1.5 1 1 0 2 2 2 1 KAP family P-loop domain T2SE PF00437.15 EFE39618.1 - 0.0037 16.2 0.0 0.0059 15.5 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.1 EFE39618.1 - 0.0054 16.3 0.0 0.0088 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFE39618.1 - 0.0074 15.7 0.0 0.023 14.2 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 EFE39618.1 - 0.0074 15.7 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_14 PF13173.1 EFE39618.1 - 0.011 15.6 0.0 0.024 14.5 0.0 1.5 2 0 0 2 2 1 0 AAA domain AAA_19 PF13245.1 EFE39618.1 - 0.012 15.3 0.0 0.04 13.6 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain AAA_33 PF13671.1 EFE39618.1 - 0.013 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFE39618.1 - 0.014 16.2 0.0 0.026 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EFE39618.1 - 0.017 15.4 0.0 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFE39618.1 - 0.018 14.7 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SMC_N PF02463.14 EFE39618.1 - 0.057 12.6 0.0 0.097 11.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Arch_ATPase PF01637.13 EFE39618.1 - 0.064 12.9 0.0 0.12 12.0 0.0 1.5 2 0 0 2 2 2 0 Archaeal ATPase RNA_helicase PF00910.17 EFE39618.1 - 0.069 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.1 EFE39618.1 - 0.08 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Guanylate_kin PF00625.16 EFE39618.1 - 0.081 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase Viral_helicase1 PF01443.13 EFE39618.1 - 0.094 12.2 0.1 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Septin PF00735.13 EFE39618.1 - 0.098 11.6 0.1 0.71 8.8 0.0 2.2 2 1 1 3 3 3 0 Septin cobW PF02492.14 EFE39618.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 EFE39618.1 - 0.16 12.1 0.1 0.4 10.8 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EFE39618.1 - 0.17 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Miro PF08477.8 EFE39618.1 - 0.19 12.2 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein PH PF00169.24 EFE39619.1 - 0.033 14.3 0.1 0.067 13.4 0.1 1.5 1 0 0 1 1 1 0 PH domain F-box-like PF12937.2 EFE39620.1 - 2.3e-07 30.4 0.0 5e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 EFE39620.1 - 7.6e-06 25.4 0.2 0.51 10.0 0.1 5.0 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) F-box PF00646.28 EFE39620.1 - 0.033 13.8 1.2 1.1 9.0 0.1 3.2 2 1 0 2 2 2 0 F-box domain DUF1688 PF07958.6 EFE39621.1 - 2.2e-170 566.7 0.0 1.5e-160 534.3 0.0 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF1688) TPR_11 PF13414.1 EFE39622.1 - 6.8e-11 41.6 0.0 3e-09 36.4 0.0 2.7 2 0 0 2 2 2 1 TPR repeat UBA PF00627.26 EFE39622.1 - 8.8e-07 28.5 0.0 3.4e-06 26.7 0.0 2.1 1 0 0 1 1 1 1 UBA/TS-N domain TPR_2 PF07719.12 EFE39622.1 - 4.2e-06 26.2 0.0 0.38 10.7 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFE39622.1 - 0.0029 17.1 0.0 3.4 7.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE39622.1 - 0.0054 16.6 0.0 0.2 11.6 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat DnaJ PF00226.26 EFE39622.1 - 0.017 14.8 0.0 0.052 13.2 0.0 1.8 1 0 0 1 1 1 0 DnaJ domain Ank_5 PF13857.1 EFE39623.1 - 6.7e-21 73.8 0.9 2.6e-12 46.5 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFE39623.1 - 3.4e-17 62.5 0.5 4.1e-16 59.0 0.3 2.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFE39623.1 - 8.8e-15 53.6 1.8 5.8e-05 22.6 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 EFE39623.1 - 5.4e-14 52.2 0.1 1.1e-08 35.3 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE39623.1 - 1.5e-11 43.3 0.4 0.018 15.2 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat AMP-binding PF00501.23 EFE39624.1 - 4.3e-81 272.4 0.0 5.6e-81 272.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 EFE39624.1 - 7.5e-27 93.9 0.0 1.2e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.20 EFE39624.1 - 4.3e-11 42.9 0.0 6.4e-09 35.9 0.0 3.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE39624.1 - 0.12 13.3 0.0 0.31 12.0 0.0 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain DegT_DnrJ_EryC1 PF01041.12 EFE39625.1 - 1.9e-59 201.5 0.0 3.3e-59 200.7 0.0 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GFO_IDH_MocA PF01408.17 EFE39625.1 - 8.7e-19 68.2 0.0 1.9e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.19 EFE39625.1 - 0.0007 19.8 0.0 0.0015 18.8 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.12 EFE39625.1 - 0.00099 18.8 0.0 0.0022 17.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding PF02629.14 EFE39625.1 - 0.0011 19.4 0.0 0.0034 17.8 0.0 1.9 1 0 0 1 1 1 1 CoA binding domain Beta_elim_lyase PF01212.16 EFE39625.1 - 0.0011 18.2 0.0 0.0022 17.1 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EFE39625.1 - 0.0025 16.6 0.0 0.0045 15.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EFE39625.1 - 0.0032 15.8 0.0 0.0052 15.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme ADP_PFK_GK PF04587.10 EFE39625.1 - 0.15 10.2 0.0 0.26 9.4 0.0 1.2 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Metallophos PF00149.23 EFE39626.1 - 0.0098 15.3 0.0 0.0098 15.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.13 EFE39627.1 - 6.4e-33 113.9 0.0 8.7e-33 113.4 0.0 1.1 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain tRNA-synt_1e PF01406.14 EFE39628.1 - 2.3e-114 381.5 0.0 3.5e-114 380.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 EFE39628.1 - 5.2e-06 25.3 0.5 0.07 11.7 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.6 EFE39628.1 - 0.0027 17.9 0.0 0.0083 16.3 0.0 1.9 1 0 0 1 1 1 1 DALR domain GCD14 PF08704.5 EFE39629.1 - 7.6e-64 215.5 0.0 4.9e-62 209.6 0.0 2.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_26 PF13659.1 EFE39629.1 - 3.8e-05 23.6 0.0 7.4e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE39629.1 - 0.0021 18.5 0.0 0.0051 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EFE39629.1 - 0.11 11.4 0.0 0.75 8.7 0.0 2.1 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase PIH1 PF08190.7 EFE39629.1 - 0.13 11.6 6.1 0.28 10.6 4.2 1.5 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 ABC_membrane PF00664.18 EFE39630.1 - 2e-70 237.3 38.4 1.1e-39 136.5 10.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE39630.1 - 7.9e-70 233.4 0.0 2.3e-34 118.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE39630.1 - 9.3e-12 44.6 7.8 0.0022 17.2 0.1 4.2 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE39630.1 - 1.9e-10 41.2 0.7 0.02 14.8 0.0 4.2 2 2 0 3 3 3 3 AAA domain AAA_29 PF13555.1 EFE39630.1 - 4.2e-09 35.8 0.5 0.0018 17.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE39630.1 - 2.1e-08 34.3 1.8 0.007 16.3 0.0 2.9 2 2 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.4 EFE39630.1 - 2.4e-07 29.7 2.4 0.002 16.7 0.1 3.2 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_17 PF13207.1 EFE39630.1 - 8.7e-07 29.7 0.0 0.063 14.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 EFE39630.1 - 9.6e-07 29.3 0.0 0.02 15.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFE39630.1 - 1.4e-06 27.6 0.5 0.015 14.4 0.0 3.2 4 0 0 4 4 4 2 Protein of unknown function, DUF258 SbcCD_C PF13558.1 EFE39630.1 - 3.5e-06 26.8 2.5 0.052 13.4 0.2 3.2 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit DEAD PF00270.24 EFE39630.1 - 2e-05 24.1 0.1 0.046 13.2 0.0 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase AAA_10 PF12846.2 EFE39630.1 - 0.00012 21.6 1.4 2.1 7.7 0.1 4.0 4 0 0 4 4 4 2 AAA-like domain AAA_22 PF13401.1 EFE39630.1 - 0.00018 21.6 3.4 0.1 12.7 0.1 4.0 2 2 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFE39630.1 - 0.00047 19.6 0.8 1.6 8.1 0.1 3.4 3 1 0 3 3 3 2 AAA domain FtsK_SpoIIIE PF01580.13 EFE39630.1 - 0.0005 19.6 0.1 0.094 12.1 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 EFE39630.1 - 0.00075 19.4 0.3 2.2 8.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.1 EFE39630.1 - 0.00081 19.7 0.0 1.4 9.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain DUF87 PF01935.12 EFE39630.1 - 0.00088 19.1 0.7 0.86 9.3 0.1 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF87 MobB PF03205.9 EFE39630.1 - 0.0015 18.2 0.1 1.2 8.7 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 EFE39630.1 - 0.0026 17.6 0.1 2.5 7.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EFE39630.1 - 0.011 15.1 3.1 11 5.4 0.0 4.5 5 0 0 5 5 5 0 IstB-like ATP binding protein AAA_5 PF07728.9 EFE39630.1 - 0.017 14.8 0.2 35 4.1 0.0 4.2 4 1 0 4 4 4 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EFE39630.1 - 0.022 13.8 0.0 7.2 5.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.1 EFE39630.1 - 0.027 14.0 1.0 7.2 6.1 0.0 3.7 3 1 0 3 3 3 0 AAA domain AAA_15 PF13175.1 EFE39630.1 - 0.034 13.2 0.0 5.1 6.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.18 EFE39630.1 - 1.5 8.6 7.2 18 5.1 0.2 3.8 5 0 0 5 5 4 0 Dynamin family adh_short PF00106.20 EFE39631.1 - 1.7e-13 50.8 0.4 1.2e-07 31.7 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 EFE39631.1 - 1.1e-06 28.6 0.0 1e-05 25.4 0.0 1.9 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFE39631.1 - 0.0034 17.4 0.0 0.012 15.5 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding KR PF08659.5 EFE39631.1 - 0.021 14.5 0.4 0.22 11.1 0.0 2.4 2 1 1 3 3 3 0 KR domain PQ-loop PF04193.9 EFE39632.1 - 1.8e-38 129.8 8.4 3.7e-19 68.0 1.8 2.7 2 0 0 2 2 2 2 PQ loop repeat NMN_transporter PF04973.7 EFE39632.1 - 5.9 6.3 8.0 1.1 8.7 2.1 2.2 2 1 0 2 2 2 0 Nicotinamide mononucleotide transporter SGS PF05002.10 EFE39633.1 - 4.5e-25 87.2 3.2 4.5e-25 87.2 2.2 2.3 2 0 0 2 2 2 1 SGS domain CS PF04969.11 EFE39633.1 - 1.2e-19 70.6 0.0 2.5e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.1 EFE39633.1 - 4.1e-08 32.7 0.1 1.2e-07 31.2 0.0 1.7 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 EFE39633.1 - 4.4e-05 22.9 1.9 0.00031 20.2 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE39633.1 - 0.00043 19.9 0.1 0.13 12.2 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE39633.1 - 0.0022 18.5 0.1 0.03 14.9 0.0 2.5 1 1 2 3 3 3 1 Tetratricopeptide repeat Prenyltrans PF00432.16 EFE39634.1 - 1.8e-30 104.1 3.9 6.5e-10 38.4 0.0 5.4 6 0 0 6 6 6 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 EFE39634.1 - 2.9e-26 91.6 0.0 1.2e-11 44.5 0.0 5.8 5 1 1 6 6 6 4 Prenyltransferase-like Prenyltrans_2 PF13249.1 EFE39634.1 - 1.2e-24 86.8 0.7 6.8e-15 55.4 0.1 4.6 3 1 1 5 5 5 3 Prenyltransferase-like Pec_lyase PF09492.5 EFE39634.1 - 3e-07 29.8 3.2 0.29 10.2 0.0 5.0 4 1 2 6 6 6 3 Pectic acid lyase A2M_comp PF07678.9 EFE39634.1 - 0.031 13.5 0.0 0.28 10.3 0.0 2.4 2 1 0 2 2 2 0 A-macroglobulin complement component Ank_2 PF12796.2 EFE39636.1 - 5e-46 154.9 18.8 9.8e-17 61.0 0.9 5.5 3 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 EFE39636.1 - 3.8e-33 111.6 13.0 5.2e-09 35.4 0.0 9.7 10 0 0 10 10 10 5 Ankyrin repeat Ank_3 PF13606.1 EFE39636.1 - 9.9e-27 90.3 12.1 3e-06 26.9 0.1 10.5 11 0 0 11 11 11 6 Ankyrin repeat Ank_4 PF13637.1 EFE39636.1 - 1.7e-26 92.0 6.5 2.3e-10 40.6 0.3 7.2 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE39636.1 - 1.8e-22 78.8 11.5 7.3e-10 38.7 0.2 6.9 3 3 4 7 7 7 4 Ankyrin repeats (many copies) F-box PF00646.28 EFE39636.1 - 8.9e-05 22.0 0.3 0.0002 20.9 0.2 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE39636.1 - 0.0017 18.0 0.1 0.0034 17.0 0.1 1.5 1 0 0 1 1 1 1 F-box-like Ras PF00071.17 EFE39637.1 - 9.3e-48 161.6 0.0 1.2e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE39637.1 - 2.3e-14 53.8 0.0 3.4e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE39637.1 - 1.5e-08 34.0 0.0 2.3e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFE39637.1 - 0.0001 21.7 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFE39637.1 - 0.053 12.6 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Pkinase PF00069.20 EFE39638.1 - 6e-35 120.6 0.0 1e-34 119.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39638.1 - 5.3e-24 84.6 0.0 9e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE39638.1 - 0.022 13.8 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF572 PF04502.8 EFE39639.1 - 0.32 10.1 35.1 0.62 9.2 24.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) Vfa1 PF08432.5 EFE39639.1 - 0.48 10.4 29.3 1 9.3 20.3 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4098 PF13345.1 EFE39640.1 - 0.0054 16.6 0.3 0.33 10.9 0.0 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4098) Sugar_tr PF00083.19 EFE39641.1 - 4.2e-17 61.8 6.8 5.1e-17 61.5 4.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Claudin_2 PF13903.1 EFE39641.1 - 0.056 13.1 6.5 0.083 12.5 4.5 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Sugar_tr PF00083.19 EFE39642.1 - 2.6e-40 138.3 8.7 3.1e-40 138.0 6.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE39642.1 - 1.1e-10 40.7 11.2 1.3e-10 40.5 7.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF791 PF05631.9 EFE39642.1 - 0.0073 15.0 1.1 0.011 14.5 0.8 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF791) HPP PF04982.8 EFE39642.1 - 4 7.3 6.8 1.3 8.9 0.3 2.5 2 1 1 3 3 3 0 HPP family Dynamin_N PF00350.18 EFE39643.1 - 6.4e-18 65.1 0.3 5.8e-17 62.0 0.0 2.7 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.18 EFE39643.1 - 2.2e-07 30.8 0.2 1.5e-05 24.9 0.1 2.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 EFE39643.1 - 9.2e-05 22.7 0.0 0.00043 20.5 0.0 2.3 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.11 EFE39643.1 - 0.00052 19.1 0.1 0.027 13.5 0.1 2.9 2 0 0 2 2 2 1 AIG1 family Adeno_IVa2 PF02456.10 EFE39643.1 - 0.00069 18.3 0.0 0.0012 17.5 0.0 1.3 1 0 0 1 1 1 1 Adenovirus IVa2 protein DUF258 PF03193.11 EFE39643.1 - 0.00094 18.4 0.0 0.0042 16.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 IIGP PF05049.8 EFE39643.1 - 0.0017 17.2 0.0 0.0057 15.5 0.0 1.9 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Miro PF08477.8 EFE39643.1 - 0.0025 18.3 0.0 0.0084 16.5 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AAA_17 PF13207.1 EFE39643.1 - 0.036 14.8 0.0 0.28 11.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EFE39643.1 - 0.048 13.1 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE39643.1 - 0.074 13.0 2.0 0.34 10.8 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain ArgK PF03308.11 EFE39643.1 - 0.08 11.7 0.2 0.14 10.8 0.1 1.3 1 0 0 1 1 1 0 ArgK protein DUF4451 PF14616.1 EFE39645.1 - 7.9e-33 112.8 0.7 1.6e-32 111.8 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Ribosomal_L24e PF01246.15 EFE39648.1 - 2e-28 98.0 2.5 4.8e-28 96.8 1.7 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e DnaJ PF00226.26 EFE39649.1 - 9.3e-07 28.4 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 EFE39649.1 - 4.1e-06 26.6 0.2 9e-06 25.5 0.2 1.6 1 1 0 1 1 1 1 Pam16 DUF3918 PF13056.1 EFE39649.1 - 0.008 15.4 0.9 0.008 15.4 0.6 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3918) Pkinase PF00069.20 EFE39650.1 - 8.2e-65 218.5 0.0 6e-63 212.4 0.0 2.1 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39650.1 - 2.4e-27 95.6 0.0 2.4e-26 92.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE39650.1 - 0.083 12.6 0.1 0.083 12.6 0.1 2.6 2 2 0 2 2 2 0 Phosphotransferase enzyme family Mito_fiss_reg PF05308.6 EFE39651.1 - 0.32 10.3 4.8 0.35 10.2 3.3 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator MFS_1 PF07690.11 EFE39652.1 - 1.3e-26 93.1 2.0 1.6e-26 92.9 1.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE39652.1 - 5.7e-08 31.7 7.2 1.1e-07 30.8 5.0 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter ATG22 PF11700.3 EFE39652.1 - 3.8e-07 28.9 5.6 7.7e-07 27.9 2.5 2.2 2 1 0 2 2 2 1 Vacuole effluxer Atg22 like MFS_2 PF13347.1 EFE39652.1 - 0.00017 20.1 4.2 0.00022 19.7 2.4 1.6 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.2 EFE39652.1 - 0.005 16.6 0.4 0.025 14.3 0.0 2.3 2 1 1 3 3 3 1 MFS_1 like family TRI12 PF06609.8 EFE39652.1 - 0.0077 14.4 0.9 0.01 14.0 0.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 EFE39652.1 - 0.0087 14.2 0.9 0.013 13.6 0.6 1.1 1 0 0 1 1 1 1 Transmembrane secretion effector Terpene_synth_C PF03936.11 EFE39654.1 - 0.00051 19.3 0.1 0.0014 17.9 0.0 1.7 2 0 0 2 2 2 1 Terpene synthase family, metal binding domain AMP-binding PF00501.23 EFE39655.1 - 3.7e-82 275.9 0.0 5.6e-82 275.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 EFE39655.1 - 2.3e-67 226.9 0.0 8.4e-38 129.9 0.0 3.9 3 1 0 3 3 3 3 Condensation domain PP-binding PF00550.20 EFE39655.1 - 2.2e-27 95.1 0.4 3.4e-12 46.4 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE39655.1 - 2.8e-06 28.1 0.1 1.5e-05 25.8 0.1 2.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ribonuclease PF00545.15 EFE39656.1 - 1.9e-18 66.2 0.1 3.1e-18 65.6 0.1 1.3 1 0 0 1 1 1 1 ribonuclease WD40 PF00400.27 EFE39657.1 - 1.7e-66 217.9 22.4 1.1e-07 31.4 0.1 11.6 12 0 0 12 12 12 10 WD domain, G-beta repeat Utp12 PF04003.7 EFE39657.1 - 3.2e-21 75.2 0.0 5.8e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 EFE39657.1 - 4.7e-06 25.0 0.7 0.023 12.8 0.0 4.6 5 0 0 5 5 5 2 Nucleoporin Nup120/160 DUF3312 PF11768.3 EFE39657.1 - 0.0046 15.2 0.1 0.1 10.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3312) Utp13 PF08625.6 EFE39657.1 - 0.06 12.9 1.0 0.088 12.4 0.0 1.7 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain P34-Arc PF04045.9 EFE39658.1 - 9e-45 152.8 0.0 1.1e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc DUF4294 PF14127.1 EFE39659.1 - 0.013 15.1 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) PP2C PF00481.16 EFE39660.1 - 1.9e-05 24.1 0.0 0.13 11.6 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 EFE39660.1 - 0.00067 19.1 0.0 0.00098 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 EFE39660.1 - 0.0016 18.1 0.1 0.0081 15.8 0.0 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) CRM1_C PF08767.6 EFE39661.1 - 8.7e-129 428.9 7.4 8.7e-129 428.9 5.1 3.5 3 2 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.7 EFE39661.1 - 6.6e-42 142.9 6.7 6.6e-42 142.9 4.6 3.1 3 1 1 4 4 4 1 Exportin 1-like protein IBN_N PF03810.14 EFE39661.1 - 5.9e-09 35.7 0.1 2.4e-08 33.7 0.1 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain HD_assoc PF13286.1 EFE39661.1 - 0.037 14.3 4.0 8.4 6.7 0.2 4.2 4 0 0 4 4 4 0 Phosphohydrolase-associated domain CIAPIN1 PF05093.8 EFE39662.1 - 4.8e-23 81.1 1.5 5.3e-23 81.0 0.2 1.7 2 0 0 2 2 2 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Myc_N PF01056.13 EFE39662.1 - 0.059 12.5 0.4 0.073 12.2 0.2 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Rft-1 PF04506.8 EFE39663.1 - 7.6e-80 268.8 13.7 9.3e-80 268.5 9.5 1.0 1 0 0 1 1 1 1 Rft protein Aminotran_1_2 PF00155.16 EFE39664.1 - 6.9e-43 146.9 0.0 8.9e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EFE39664.1 - 1.4e-08 34.2 0.0 2.8e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EFE39664.1 - 2.1e-06 26.3 0.0 3.1e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EFE39664.1 - 4.5e-06 25.6 0.0 7.2e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFE39664.1 - 2.8e-05 23.3 0.0 4.7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family ABC2_membrane PF01061.19 EFE39665.1 - 3e-37 127.8 19.0 5.1e-37 127.0 13.2 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 EFE39665.1 - 9.4e-27 93.9 0.1 1.8e-26 93.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EFE39665.1 - 5.5e-10 39.6 0.2 5.9e-09 36.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.2 EFE39665.1 - 1.4e-08 34.1 20.4 2.9e-08 33.1 13.4 2.2 2 1 0 2 2 2 1 ABC-2 family transporter protein hEGF PF12661.2 EFE39665.1 - 4.3e-05 23.3 22.5 0.01 15.8 1.9 3.9 3 0 0 3 3 3 2 Human growth factor-like EGF AAA_25 PF13481.1 EFE39665.1 - 6e-05 22.5 0.0 0.0096 15.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain EGF_2 PF07974.8 EFE39665.1 - 0.00038 20.5 11.4 0.00038 20.5 7.9 3.8 4 0 0 4 4 3 2 EGF-like domain AAA_15 PF13175.1 EFE39665.1 - 0.0012 18.0 0.0 0.59 9.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EFE39665.1 - 0.0021 17.5 0.1 0.0051 16.3 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATP-synt_ab PF00006.20 EFE39665.1 - 0.0027 17.2 0.0 0.0047 16.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF258 PF03193.11 EFE39665.1 - 0.0077 15.4 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 cobW PF02492.14 EFE39665.1 - 0.0095 15.3 0.1 0.025 14.0 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.1 EFE39665.1 - 0.015 15.4 0.0 0.036 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFE39665.1 - 0.019 15.7 0.0 0.044 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFE39665.1 - 0.029 14.2 0.0 0.069 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFE39665.1 - 0.032 14.2 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.14 EFE39665.1 - 0.032 13.4 0.1 0.14 11.3 0.1 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 EFE39665.1 - 0.034 14.4 0.0 0.076 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF1212 PF06738.7 EFE39665.1 - 0.04 13.3 1.6 0.095 12.1 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) AAA_23 PF13476.1 EFE39665.1 - 0.056 13.7 1.4 0.064 13.5 0.1 1.7 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.1 EFE39665.1 - 0.11 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Glycophorin_A PF01102.13 EFE39665.1 - 0.18 11.5 1.5 0.43 10.3 0.0 2.5 2 0 0 2 2 1 0 Glycophorin A MFS_1 PF07690.11 EFE39666.1 - 4.4e-18 65.1 34.5 4.4e-18 65.1 23.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Cornichon PF03311.9 EFE39667.1 - 5e-22 78.4 0.8 6e-22 78.1 0.6 1.3 1 0 0 1 1 1 1 Cornichon protein PSP1 PF04468.7 EFE39668.1 - 5e-31 106.5 1.3 8e-31 105.8 0.9 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Rotavirus_VP3 PF06929.6 EFE39668.1 - 0.29 8.9 0.4 0.44 8.3 0.3 1.1 1 0 0 1 1 1 0 Rotavirus VP3 protein Nfu_N PF08712.6 EFE39669.1 - 3.3e-25 87.5 0.0 9.6e-25 86.0 0.0 1.8 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 EFE39669.1 - 8.1e-23 79.9 0.1 2e-22 78.7 0.0 1.7 2 0 0 2 2 2 1 NifU-like domain RasGEF PF00617.14 EFE39670.1 - 9.5e-43 146.1 0.4 1.7e-42 145.3 0.3 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EFE39670.1 - 1.4e-13 50.8 0.0 3.5e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif SR-25 PF10500.4 EFE39671.1 - 9.8 5.5 8.9 5.5 6.3 0.4 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Miro PF08477.8 EFE39672.1 - 6.6e-06 26.6 0.0 1.1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 EFE39672.1 - 0.04 13.9 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.13 EFE39672.1 - 0.078 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Septin Spore_IV_A PF09547.5 EFE39672.1 - 0.091 11.4 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) FtsK_SpoIIIE PF01580.13 EFE39672.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF258 PF03193.11 EFE39672.1 - 0.11 11.6 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 EFE39672.1 - 0.12 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.15 EFE39672.1 - 0.13 10.9 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit ATP_bind_1 PF03029.12 EFE39672.1 - 0.14 11.6 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Ebola_NP PF05505.7 EFE39673.1 - 0.043 11.8 5.0 0.047 11.7 3.5 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein DUF966 PF06136.8 EFE39673.1 - 0.049 13.0 11.0 0.062 12.7 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF1996 PF09362.5 EFE39673.1 - 0.19 11.3 1.6 0.22 11.2 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1996) EcsB PF05975.7 EFE39673.1 - 0.47 8.8 4.1 0.14 10.6 0.8 1.5 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB FRG1 PF06229.7 EFE39673.1 - 0.9 8.9 11.1 0.96 8.8 7.1 1.5 1 1 0 1 1 1 0 FRG1-like family RNA_pol_3_Rpc31 PF11705.3 EFE39673.1 - 4.7 7.0 15.3 7.2 6.4 10.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 BTV_NS2 PF04514.7 EFE39673.1 - 7.4 5.3 16.9 11 4.8 11.7 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF2052 PF09747.4 EFE39673.1 - 8.9 6.1 22.6 6.5 6.6 10.6 2.1 1 1 1 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Atrophin-1 PF03154.10 EFE39674.1 - 0.0011 17.2 3.2 0.0015 16.8 2.2 1.1 1 0 0 1 1 1 1 Atrophin-1 family FAM176 PF14851.1 EFE39674.1 - 0.1 12.2 0.2 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 FAM176 family AFT PF08731.6 EFE39674.1 - 1.2 9.3 4.7 0.38 10.9 1.0 1.7 1 1 1 2 2 2 0 Transcription factor AFT FAR1 PF03101.10 EFE39674.1 - 1.3 9.6 4.6 76 3.9 3.2 2.3 1 1 0 1 1 1 0 FAR1 DNA-binding domain Cyclin_N PF00134.18 EFE39675.1 - 9.8e-11 41.3 0.0 2.7e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.6 EFE39675.1 - 1.6e-08 35.0 0.0 2.9e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin AAA PF00004.24 EFE39676.1 - 2.9e-45 153.7 0.1 9.2e-45 152.0 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFE39676.1 - 1.2e-09 38.0 0.6 1.6e-08 34.3 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFE39676.1 - 6.1e-08 32.7 0.0 1.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EFE39676.1 - 6.7e-07 29.4 0.0 3e-06 27.3 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFE39676.1 - 2.2e-06 27.8 2.6 0.0013 18.8 0.0 3.1 2 1 1 3 3 3 1 AAA domain DUF815 PF05673.8 EFE39676.1 - 9.7e-06 24.6 0.0 2.5e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_14 PF13173.1 EFE39676.1 - 5.3e-05 23.1 0.0 0.00079 19.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 EFE39676.1 - 0.00021 21.2 0.0 0.0012 18.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 EFE39676.1 - 0.00027 20.0 0.0 0.0011 18.0 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EFE39676.1 - 0.00065 20.5 0.0 0.0027 18.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 EFE39676.1 - 0.0011 18.6 0.8 0.07 12.7 0.0 3.1 3 1 0 3 3 3 1 NACHT domain Zeta_toxin PF06414.7 EFE39676.1 - 0.0014 17.7 0.1 0.0044 16.1 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 EFE39676.1 - 0.0017 18.0 0.2 0.0043 16.7 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 EFE39676.1 - 0.0019 18.3 0.0 0.0043 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.10 EFE39676.1 - 0.0038 16.9 0.0 0.012 15.2 0.0 1.9 2 0 0 2 2 1 1 NTPase AAA_3 PF07726.6 EFE39676.1 - 0.005 16.4 0.0 0.014 14.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 EFE39676.1 - 0.0059 16.2 0.1 0.042 13.4 0.0 2.1 1 1 1 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_33 PF13671.1 EFE39676.1 - 0.006 16.4 0.0 0.015 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EFE39676.1 - 0.0075 15.4 0.0 0.019 14.1 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 EFE39676.1 - 0.0093 14.7 0.0 0.016 13.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_25 PF13481.1 EFE39676.1 - 0.01 15.2 2.4 0.069 12.5 0.1 2.8 2 1 1 3 3 3 0 AAA domain AAA_11 PF13086.1 EFE39676.1 - 0.011 15.3 0.0 0.029 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 EFE39676.1 - 0.011 15.1 0.0 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Arch_ATPase PF01637.13 EFE39676.1 - 0.012 15.3 1.1 0.074 12.7 0.0 2.6 2 1 0 2 2 2 0 Archaeal ATPase AAA_24 PF13479.1 EFE39676.1 - 0.016 14.7 0.1 0.037 13.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EFE39676.1 - 0.019 14.5 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFE39676.1 - 0.024 14.9 0.0 0.14 12.4 0.0 2.3 2 1 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 EFE39676.1 - 0.025 14.2 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein USP8_dimer PF08969.6 EFE39676.1 - 0.028 14.3 0.3 0.082 12.8 0.2 1.8 1 0 0 1 1 1 0 USP8 dimerisation domain KaiC PF06745.8 EFE39676.1 - 0.037 13.1 0.1 0.62 9.1 0.0 2.3 2 0 0 2 2 2 0 KaiC Sigma54_activat PF00158.21 EFE39676.1 - 0.071 12.5 0.1 1.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 EFE39676.1 - 0.11 12.5 0.0 0.39 10.7 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.17 EFE39676.1 - 0.12 11.1 0.0 0.23 10.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.12 EFE39676.1 - 0.21 10.4 0.0 0.37 9.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Asp PF00026.18 EFE39677.1 - 1.5e-108 362.8 1.2 1.8e-108 362.5 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFE39677.1 - 1.2e-11 44.8 0.3 5.1e-11 42.7 0.2 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFE39677.1 - 2e-07 31.3 0.5 0.0031 17.9 0.0 3.4 4 1 0 4 4 4 2 Aspartyl protease TAXi_C PF14541.1 EFE39677.1 - 5.3e-05 22.8 0.0 0.00056 19.4 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal NIF PF03031.13 EFE39678.1 - 7.6e-28 97.1 0.1 1.4e-27 96.2 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 EFE39678.1 - 3.2e-12 46.1 0.1 6.3e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 EFE39678.1 - 6e-10 39.1 0.0 2.7e-09 37.0 0.0 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Biotin_lipoyl_2 PF13533.1 EFE39678.1 - 0.0085 15.7 0.0 5.6 6.7 0.0 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like MARVEL PF01284.18 EFE39680.1 - 0.00034 20.4 7.9 0.00061 19.6 5.5 1.4 1 1 0 1 1 1 1 Membrane-associating domain Arginase PF00491.16 EFE39682.1 - 7.9e-76 254.9 0.7 9.7e-76 254.6 0.5 1.1 1 0 0 1 1 1 1 Arginase family Saccharop_dh PF03435.13 EFE39682.1 - 0.11 11.3 0.0 0.43 9.5 0.0 1.8 1 1 1 2 2 2 0 Saccharopine dehydrogenase GatB_N PF02934.10 EFE39683.1 - 1.2e-60 204.8 0.0 1.6e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 EFE39683.1 - 1e-23 83.7 0.0 1.7e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 GatB domain GatB_N PF02934.10 EFE39684.1 - 5.4e-05 22.1 0.1 7.6e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain TPR_1 PF00515.23 EFE39687.1 - 7.1e-50 164.6 31.2 5.6e-08 32.0 0.0 11.3 10 2 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.12 EFE39687.1 - 3.3e-45 148.3 22.7 8.9e-06 25.2 0.0 11.3 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_11 PF13414.1 EFE39687.1 - 5.1e-43 144.5 22.1 1.1e-10 40.9 0.1 6.5 3 2 3 6 6 6 6 TPR repeat TPR_8 PF13181.1 EFE39687.1 - 5.6e-36 119.6 21.7 3.6e-05 23.2 0.6 10.3 8 1 2 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.1 EFE39687.1 - 8.1e-28 96.4 30.8 3.4e-06 27.5 0.0 7.2 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 EFE39687.1 - 1.6e-24 85.5 36.4 5.1e-08 32.7 0.7 8.0 3 2 6 9 9 8 6 Tetratricopeptide repeat TPR_17 PF13431.1 EFE39687.1 - 1e-21 75.2 30.1 0.00028 20.8 0.1 10.3 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_7 PF13176.1 EFE39687.1 - 1.1e-18 65.4 17.6 0.01 15.5 0.1 9.4 9 1 0 9 9 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE39687.1 - 5e-18 63.9 39.9 0.00015 22.0 0.1 11.5 5 2 8 13 13 10 7 Tetratricopeptide repeat TPR_6 PF13174.1 EFE39687.1 - 7.4e-18 63.7 33.8 0.0021 18.3 0.0 11.3 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_19 PF14559.1 EFE39687.1 - 3.7e-15 56.0 38.4 2e-06 28.0 0.3 7.5 6 2 3 9 9 7 5 Tetratricopeptide repeat Apc3 PF12895.2 EFE39687.1 - 1.9e-13 50.3 11.4 4.4e-08 33.1 2.2 4.0 4 1 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 EFE39687.1 - 1.1e-08 34.7 32.8 0.00016 21.4 0.2 7.4 4 2 3 8 8 7 3 Tetratricopeptide repeat DUF1777 PF08648.7 EFE39687.1 - 5e-05 23.1 49.2 5e-05 23.1 34.1 4.5 5 0 0 5 5 4 1 Protein of unknown function (DUF1777) TPR_15 PF13429.1 EFE39687.1 - 0.00059 18.9 25.8 0.0024 16.9 1.6 5.3 2 1 2 5 5 4 3 Tetratricopeptide repeat DUF2225 PF09986.4 EFE39687.1 - 0.0014 18.1 5.4 0.62 9.4 0.0 3.0 3 1 0 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) CAF-1_p150 PF11600.3 EFE39687.1 - 0.0016 17.8 29.5 0.0016 17.8 20.4 4.0 4 0 0 4 4 4 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal ChAPs PF09295.5 EFE39687.1 - 0.69 8.6 2.8 3 6.4 0.2 2.6 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_21 PF09976.4 EFE39687.1 - 4.2 7.2 34.6 0.25 11.2 2.8 4.8 3 1 1 4 4 3 0 Tetratricopeptide repeat DUF3539 PF12058.3 EFE39688.1 - 0.026 14.3 0.9 0.03 14.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) Cnd1_N PF12922.2 EFE39688.1 - 0.033 13.8 0.1 0.036 13.6 0.1 1.1 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term UPF0239 PF06783.6 EFE39688.1 - 0.07 13.0 0.1 0.092 12.6 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) BAR PF03114.13 EFE39689.1 - 5.7e-58 196.1 5.8 2.1e-57 194.2 4.0 1.8 1 1 0 1 1 1 1 BAR domain DUF1204 PF06721.6 EFE39689.1 - 0.61 9.2 5.8 0.14 11.3 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1204) AT_hook PF02178.14 EFE39690.1 - 0.011 15.2 1.6 0.057 13.1 1.1 2.3 1 0 0 1 1 1 0 AT hook motif SSXT PF05030.7 EFE39692.1 - 2.2e-05 23.9 1.7 0.48 10.0 0.0 3.2 3 0 0 3 3 3 2 SSXT protein (N-terminal region) POX PF07526.6 EFE39692.1 - 0.28 11.4 2.0 0.63 10.2 0.0 2.3 2 1 1 3 3 3 0 Associated with HOX Tmemb_55A PF09788.4 EFE39692.1 - 4.4 6.3 7.6 0.25 10.4 1.0 1.9 2 0 0 2 2 2 0 Transmembrane protein 55A Pkinase PF00069.20 EFE39694.1 - 3.4e-10 39.5 0.0 5.9e-10 38.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39694.1 - 1e-07 31.3 0.0 8e-07 28.3 0.0 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EFE39694.1 - 6.1e-07 29.4 0.2 0.00025 20.8 0.3 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE39694.1 - 5.9e-06 26.0 0.2 0.011 15.3 0.0 2.2 1 1 1 2 2 2 2 Choline/ethanolamine kinase Kdo PF06293.9 EFE39694.1 - 0.0049 15.9 0.0 0.0081 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC_membrane PF00664.18 EFE39695.1 - 1.1e-78 264.4 36.8 1.3e-42 146.1 8.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE39695.1 - 1.9e-71 238.7 0.0 2.7e-35 121.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE39695.1 - 1.6e-15 56.9 6.3 1.6e-06 27.5 0.8 4.4 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE39695.1 - 8.4e-14 52.1 0.0 0.00078 19.4 0.0 4.3 3 1 0 3 3 3 3 AAA domain AAA_16 PF13191.1 EFE39695.1 - 2e-08 34.4 11.5 0.00026 21.0 0.1 3.9 3 2 1 4 4 3 2 AAA ATPase domain ABC_ATPase PF09818.4 EFE39695.1 - 2.9e-08 32.7 3.9 0.0035 15.9 0.1 3.3 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_29 PF13555.1 EFE39695.1 - 4e-08 32.6 0.1 0.005 16.3 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 EFE39695.1 - 4.1e-08 33.4 0.8 0.013 15.6 0.0 4.0 2 2 0 2 2 2 2 AAA domain AAA_30 PF13604.1 EFE39695.1 - 4.6e-08 32.8 1.8 0.019 14.5 0.0 4.5 2 2 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EFE39695.1 - 7.5e-07 30.0 0.2 0.027 15.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 EFE39695.1 - 9.7e-07 28.1 0.0 0.0048 16.0 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA PF00004.24 EFE39695.1 - 1e-05 25.7 1.2 0.62 10.2 0.1 4.2 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EFE39695.1 - 2e-05 24.1 1.1 0.093 12.1 0.0 3.4 4 0 0 4 4 3 2 AAA domain AAA_23 PF13476.1 EFE39695.1 - 8.3e-05 22.9 0.9 0.2 11.9 0.5 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 EFE39695.1 - 0.00013 21.8 0.0 0.84 9.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EFE39695.1 - 0.00031 20.4 0.2 0.43 10.3 0.0 3.5 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EFE39695.1 - 0.00058 19.0 0.4 0.57 9.2 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin AAA_18 PF13238.1 EFE39695.1 - 0.00061 20.1 0.0 0.36 11.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 EFE39695.1 - 0.0009 19.1 2.3 0.41 10.5 0.2 3.3 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 EFE39695.1 - 0.0018 17.7 1.3 3.9 6.8 0.1 4.2 4 0 0 4 4 4 1 AAA-like domain AAA_14 PF13173.1 EFE39695.1 - 0.0021 17.9 0.1 4.9 7.0 0.0 4.1 5 0 0 5 5 5 0 AAA domain Rad17 PF03215.10 EFE39695.1 - 0.015 14.0 0.0 0.03 13.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF87 PF01935.12 EFE39695.1 - 0.024 14.4 0.3 0.49 10.1 0.1 2.8 3 0 0 3 3 2 0 Domain of unknown function DUF87 MobB PF03205.9 EFE39695.1 - 0.029 14.0 0.1 9.4 5.9 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.15 EFE39695.1 - 0.031 13.9 0.0 4.6 6.8 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_24 PF13479.1 EFE39695.1 - 0.042 13.4 0.4 0.62 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain PRK PF00485.13 EFE39695.1 - 0.066 12.7 0.1 0.35 10.4 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MMR_HSR1 PF01926.18 EFE39695.1 - 0.073 13.0 0.7 7.4 6.5 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.17 EFE39695.1 - 0.099 12.8 0.1 3.6 7.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 EFE39695.1 - 0.11 12.4 0.4 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 EFE39695.1 - 0.12 11.8 1.3 16 4.8 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.1 EFE39695.1 - 0.14 11.1 0.0 0.61 9.0 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain p450 PF00067.17 EFE39696.1 - 1.1e-34 119.8 0.0 3.4e-32 111.5 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.13 EFE39697.1 - 2.3e-15 56.2 1.4 4.2e-15 55.3 1.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE39697.1 - 6.2e-06 26.0 10.2 1.4e-05 24.9 7.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 EFE39697.1 - 2 8.6 10.0 5.3 7.2 7.0 1.7 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region TPR_11 PF13414.1 EFE39698.1 - 1.7e-09 37.1 6.1 7.2e-09 35.1 0.2 2.8 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 EFE39698.1 - 3.6e-06 26.3 2.5 0.96 9.1 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF3808 PF10300.4 EFE39698.1 - 6.3e-05 21.7 0.4 8.7e-05 21.2 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.12 EFE39698.1 - 0.0069 16.2 3.7 2.2 8.4 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE39698.1 - 0.069 13.2 1.9 0.11 12.6 0.6 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 peroxidase PF00141.18 EFE39699.1 - 3.9e-47 160.6 0.0 6.4e-47 159.9 0.0 1.4 1 0 0 1 1 1 1 Peroxidase Syntaxin PF00804.20 EFE39699.1 - 0.09 12.9 4.1 0.22 11.7 2.8 1.6 1 0 0 1 1 1 0 Syntaxin HrcA PF01628.16 EFE39700.1 - 0.071 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 HrcA protein C terminal domain Pkinase PF00069.20 EFE39701.1 - 1.5e-10 40.6 0.0 1.7e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39701.1 - 3.6e-08 32.7 0.0 4.6e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase COesterase PF00135.23 EFE39702.1 - 2.1e-54 185.1 0.0 2.9e-54 184.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE39702.1 - 1.8e-05 24.4 0.0 7.2e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Zn_clus PF00172.13 EFE39703.1 - 7.5e-09 35.3 6.3 1.5e-08 34.4 4.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Crp PF00325.15 EFE39703.1 - 0.026 13.9 0.1 0.34 10.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Pyridoxal_deC PF00282.14 EFE39704.1 - 1.3e-74 250.9 0.0 1.7e-74 250.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 EFE39704.1 - 1.7e-05 23.7 0.0 2.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.15 EFE39704.1 - 0.0086 14.6 0.1 0.047 12.2 0.0 2.0 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, major domain Peptidase_S8 PF00082.17 EFE39705.1 - 2.1e-21 76.3 0.5 2.3e-21 76.1 0.3 1.0 1 0 0 1 1 1 1 Subtilase family eIF-5_eIF-2B PF01873.12 EFE39706.1 - 9.9e-36 122.1 0.0 1.6e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.13 EFE39706.1 - 1.8e-25 88.6 0.8 5.7e-25 87.0 0.6 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon RNase_T PF00929.19 EFE39707.1 - 0.029 14.6 0.0 0.064 13.5 0.0 1.5 1 0 0 1 1 1 0 Exonuclease DUF824 PF05688.6 EFE39707.1 - 0.042 13.4 0.0 0.094 12.3 0.0 1.5 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) DUF4319 PF14203.1 EFE39707.1 - 0.096 12.2 0.5 1.2 8.7 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4319) GMC_oxred_N PF00732.14 EFE39708.1 - 3.9e-46 157.5 0.0 5e-46 157.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFE39708.1 - 6.9e-35 120.4 0.0 1.1e-34 119.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 EFE39708.1 - 0.031 13.1 0.4 0.054 12.4 0.1 1.4 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_2 PF00890.19 EFE39708.1 - 0.067 12.0 1.4 0.2 10.4 0.7 1.8 2 0 0 2 2 2 0 FAD binding domain NAD_binding_8 PF13450.1 EFE39708.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFE39708.1 - 0.12 10.8 0.3 0.17 10.3 0.2 1.1 1 0 0 1 1 1 0 HI0933-like protein DAO PF01266.19 EFE39708.1 - 0.13 11.0 0.1 0.23 10.2 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_oxidored PF12831.2 EFE39708.1 - 0.38 9.7 1.2 0.59 9.1 0.8 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Catalase PF00199.14 EFE39709.1 - 5.1e-103 344.7 1.7 6.7e-103 344.3 1.2 1.1 1 0 0 1 1 1 1 Catalase DUF2373 PF10180.4 EFE39710.1 - 0.11 12.0 0.0 0.3 10.6 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) Myb_DNA-bind_6 PF13921.1 EFE39711.1 - 2.3e-14 53.2 0.1 1.9e-06 27.9 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFE39711.1 - 4.6e-10 39.3 0.3 0.00012 22.1 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain PX PF00787.19 EFE39712.1 - 8.8e-26 89.9 0.2 8.8e-26 89.9 0.1 1.5 2 0 0 2 2 2 1 PX domain Peptidase_A2E PF12382.3 EFE39712.1 - 0.055 13.2 0.1 0.4 10.4 0.0 2.0 2 0 0 2 2 2 0 Retrotransposon peptidase MDFI PF15316.1 EFE39712.1 - 0.48 10.3 1.5 0.75 9.7 1.0 1.2 1 0 0 1 1 1 0 MyoD family inhibitor WD40 PF00400.27 EFE39713.1 - 8.6e-23 79.3 12.8 0.00014 21.5 0.0 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 EFE39713.1 - 3.2e-05 22.3 2.8 0.053 11.8 0.1 3.9 3 1 1 4 4 4 3 Cytochrome D1 heme domain PQQ_3 PF13570.1 EFE39713.1 - 0.00036 20.7 2.1 0.2 11.9 0.1 4.0 4 0 0 4 4 4 1 PQQ-like domain PD40 PF07676.7 EFE39713.1 - 0.07 12.8 0.0 0.07 12.8 0.0 2.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Sigma70_ner PF04546.8 EFE39713.1 - 0.85 9.1 6.1 1.3 8.5 4.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.7 EFE39713.1 - 6.9 4.4 13.5 9.1 4.0 9.4 1.0 1 0 0 1 1 1 0 Nop14-like family RRM_6 PF14259.1 EFE39714.1 - 6.6e-09 35.6 0.0 1.1e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE39714.1 - 8.6e-07 28.4 0.0 1.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39714.1 - 0.0011 18.7 0.1 0.0025 17.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SecE PF00584.15 EFE39715.1 - 1.9e-08 33.7 0.0 3.4e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Mito_carr PF00153.22 EFE39717.1 - 2.2e-73 242.0 2.5 9.1e-25 86.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1049 PF06305.6 EFE39717.1 - 0.038 13.4 0.0 5.5 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) FAM74 PF15026.1 EFE39718.1 - 0.052 13.1 7.6 0.06 12.9 5.3 1.1 1 0 0 1 1 1 0 FAM74 protein U79_P34 PF03064.11 EFE39718.1 - 0.087 12.3 6.2 0.091 12.2 4.3 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Selenoprotein_S PF06936.6 EFE39718.1 - 0.7 9.4 7.1 0.72 9.3 4.9 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) TRAP_alpha PF03896.11 EFE39718.1 - 1.7 7.5 4.7 1.9 7.4 3.3 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol3_a_NII PF11490.3 EFE39718.1 - 2.4 7.7 7.7 3 7.4 5.3 1.2 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II CDC45 PF02724.9 EFE39718.1 - 3.6 5.4 8.1 4.1 5.3 5.6 1.0 1 0 0 1 1 1 0 CDC45-like protein YqfQ PF14181.1 EFE39718.1 - 3.7 7.5 7.0 4.1 7.4 4.9 1.1 1 0 0 1 1 1 0 YqfQ-like protein Phage_Gp23 PF10669.4 EFE39718.1 - 4.7 7.3 6.9 5.9 7.0 4.8 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF1682 PF07946.9 EFE39718.1 - 5.2 5.8 9.3 5.3 5.7 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Kinesin PF00225.18 EFE39719.1 - 2.3e-88 296.1 0.0 2.3e-88 296.1 0.0 3.2 4 0 0 4 4 4 1 Kinesin motor domain IncA PF04156.9 EFE39719.1 - 0.00084 18.9 5.6 0.00084 18.9 3.9 11.1 4 3 5 9 9 9 2 IncA protein Glycos_transf_1 PF00534.15 EFE39720.1 - 4.7e-30 104.2 0.0 3.1e-28 98.3 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EFE39720.1 - 1.5e-11 44.3 0.0 9.7e-11 41.7 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 EFE39720.1 - 1.1e-09 38.5 0.9 2.1e-09 37.7 0.6 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 EFE39720.1 - 2.2e-07 31.0 0.1 1.1e-05 25.5 0.0 2.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EFE39720.1 - 7.1e-06 26.2 0.0 1.4e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Peptidase_M19 PF01244.16 EFE39721.1 - 7.1e-109 363.6 0.0 8.4e-109 363.3 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) ERCC4 PF02732.10 EFE39722.1 - 5.6e-15 55.3 0.2 3.9e-14 52.6 0.1 2.5 1 1 0 1 1 1 1 ERCC4 domain MFS_1 PF07690.11 EFE39723.1 - 1e-15 57.3 27.3 1e-15 57.3 18.9 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Nodulin-like PF06813.8 EFE39723.1 - 0.001 18.3 15.3 0.0022 17.2 0.6 3.8 3 1 1 4 4 4 2 Nodulin-like DUF2626 PF11117.3 EFE39723.1 - 0.19 12.1 8.0 0.51 10.7 0.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2626) NARP1 PF12569.3 EFE39724.1 - 0.062 12.0 1.1 0.067 11.9 0.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PI3K_1B_p101 PF10486.4 EFE39724.1 - 0.23 8.9 4.6 0.23 8.9 3.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Tom22 PF04281.8 EFE39724.1 - 0.33 10.4 5.5 0.5 9.8 3.8 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 BSP_II PF05432.6 EFE39724.1 - 0.42 9.8 12.2 0.47 9.6 8.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RNA_polI_A34 PF08208.6 EFE39724.1 - 0.42 10.2 6.4 0.48 10.0 4.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF2956 PF11169.3 EFE39724.1 - 1.2 9.0 4.3 0.16 11.8 0.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) alpha-hel2 PF14456.1 EFE39724.1 - 2.5 6.8 5.0 2.3 6.8 3.4 1.1 1 0 0 1 1 1 0 Alpha-helical domain 2 Rhabdo_ncap PF00945.13 EFE39724.1 - 3.6 6.0 6.9 4 5.9 4.8 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DNA_pol_phi PF04931.8 EFE39724.1 - 3.7 5.2 11.8 3.3 5.3 8.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi HSP90 PF00183.13 EFE39724.1 - 5.3 5.3 7.8 4.6 5.5 5.4 1.1 1 0 0 1 1 1 0 Hsp90 protein eIF-3c_N PF05470.7 EFE39724.1 - 7.5 4.5 7.2 7.6 4.4 5.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Paf1 PF03985.8 EFE39724.1 - 8.1 5.0 9.3 8.4 5.0 6.4 1.1 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.9 EFE39724.1 - 8.5 4.2 10.2 8.8 4.2 7.1 1.1 1 0 0 1 1 1 0 CDC45-like protein CDC27 PF09507.5 EFE39724.1 - 9.8 5.2 11.3 11 5.0 7.8 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF1676 PF07898.8 EFE39725.1 - 1 9.7 10.8 3.7 7.8 7.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) IPK PF03770.11 EFE39726.1 - 6.2e-56 189.1 0.0 6.2e-56 189.1 0.0 1.8 2 0 0 2 2 2 1 Inositol polyphosphate kinase Pam17 PF08566.5 EFE39726.1 - 0.035 13.8 0.1 0.093 12.4 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 LRR_4 PF12799.2 EFE39727.1 - 2.5e-22 78.0 36.9 2.1e-07 30.3 3.3 9.0 4 2 6 11 11 11 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE39727.1 - 1.2e-18 66.5 42.3 1.2e-05 24.9 2.1 7.1 6 2 1 7 7 7 5 Leucine rich repeat LRR_1 PF00560.28 EFE39727.1 - 8e-09 34.3 38.5 0.77 10.0 0.8 13.2 13 1 1 14 14 14 3 Leucine Rich Repeat LRR_9 PF14580.1 EFE39727.1 - 6.3e-08 32.3 10.8 0.0038 16.8 0.8 4.2 3 1 1 4 4 4 4 Leucine-rich repeat LRR_7 PF13504.1 EFE39727.1 - 2.6e-05 23.7 38.1 4.6 7.8 0.2 12.1 12 0 0 12 12 12 2 Leucine rich repeat LRR_6 PF13516.1 EFE39727.1 - 0.14 12.3 45.5 0.56 10.4 1.7 10.5 9 3 4 13 13 13 0 Leucine Rich repeat Adaptin_binding PF10199.4 EFE39729.1 - 4.1e-17 62.7 6.3 1.1e-16 61.4 4.3 1.7 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 PGP_phosphatase PF09419.5 EFE39730.1 - 2.8e-52 176.4 0.0 6.4e-52 175.2 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 EFE39730.1 - 1.5e-05 24.5 0.0 2.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EFE39730.1 - 0.0022 18.4 0.3 1.1 9.5 0.1 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Homeobox PF00046.24 EFE39731.1 - 2.9e-20 71.6 2.5 6.4e-20 70.5 1.7 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EFE39731.1 - 6.6e-05 22.5 0.3 0.00019 21.0 0.2 1.8 1 0 0 1 1 1 1 Homeobox KN domain Aldedh PF00171.17 EFE39734.1 - 5.5e-103 344.7 0.0 7.6e-103 344.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Tubulin PF00091.20 EFE39735.1 - 4.2e-57 193.4 0.0 7.5e-57 192.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EFE39735.1 - 1.4e-49 167.3 0.2 2.4e-49 166.5 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 EFE39735.1 - 0.0048 16.3 0.0 0.0092 15.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain RRM_6 PF14259.1 EFE39736.1 - 6.2e-12 45.3 0.0 0.00021 21.2 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE39736.1 - 1.3e-11 43.9 0.1 0.00042 19.8 0.0 3.8 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39736.1 - 7.5e-09 35.3 0.1 4.1e-05 23.3 0.0 3.1 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_S49_N PF08496.5 EFE39736.1 - 0.086 12.6 2.7 0.12 12.1 0.3 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PHA_gran_rgn PF09650.5 EFE39736.1 - 0.1 12.6 0.3 19 5.4 0.0 3.2 3 0 0 3 3 3 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) Pkinase PF00069.20 EFE39737.1 - 1.4e-65 221.0 0.0 2.2e-65 220.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39737.1 - 3.2e-35 121.4 0.0 5.9e-35 120.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE39737.1 - 2.3e-08 33.3 0.0 6.6e-08 31.8 0.0 1.7 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 EFE39737.1 - 0.00014 21.6 0.0 0.0035 17.0 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFE39737.1 - 0.0081 15.0 0.1 0.015 14.1 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.17 EFE39737.1 - 0.088 12.1 0.3 0.18 11.1 0.2 1.4 1 0 0 1 1 1 0 RIO1 family TPR_6 PF13174.1 EFE39738.1 - 0.044 14.2 2.7 41 4.9 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE39738.1 - 0.058 13.7 2.6 0.33 11.3 0.1 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat LANC_like PF05147.8 EFE39739.1 - 5.6e-22 77.7 0.0 8.6e-21 73.8 0.0 2.2 1 1 0 1 1 1 1 Lanthionine synthetase C-like protein CBF PF03914.12 EFE39740.1 - 2.7e-49 166.7 0.1 1.5e-48 164.3 0.0 2.4 1 0 0 1 1 1 1 CBF/Mak21 family Prok-E2_C PF14459.1 EFE39740.1 - 0.033 14.2 0.0 0.081 13.0 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic E2 family C tRNA-synt_2b PF00587.20 EFE39741.1 - 1.9e-32 112.2 0.0 2.9e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFE39741.1 - 5.7e-10 38.9 0.0 1.4e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain TF_Zn_Ribbon PF08271.7 EFE39741.1 - 0.15 11.4 3.1 1.3 8.4 0.2 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding tRNA-synt_2 PF00152.15 EFE39741.1 - 0.16 10.6 0.0 0.22 10.2 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Prefoldin PF02996.12 EFE39742.1 - 2.2e-15 56.3 0.0 2.9e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit KH_3 PF13014.1 EFE39743.1 - 0.06 13.0 0.0 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 KH domain CAP PF00188.21 EFE39744.1 - 3.4e-16 59.8 8.6 4.6e-16 59.4 6.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Abhydrolase_6 PF12697.2 EFE39745.1 - 2.3e-21 76.7 0.0 7e-21 75.1 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE39745.1 - 1.4e-08 34.5 0.0 9.3e-08 31.9 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE39745.1 - 2.6e-05 24.0 0.0 0.00012 21.8 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family EHN PF06441.7 EFE39745.1 - 0.00068 19.5 0.6 0.0018 18.1 0.2 1.9 2 0 0 2 2 2 1 Epoxide hydrolase N terminus CDV3 PF15359.1 EFE39745.1 - 0.027 14.5 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 Glyco_transf_8 PF01501.15 EFE39746.1 - 2.3e-26 92.6 0.0 3.8e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 HEAT PF02985.17 EFE39747.1 - 1.1e-47 155.7 14.8 0.0028 17.5 0.1 12.9 14 0 0 14 14 14 12 HEAT repeat HEAT_2 PF13646.1 EFE39747.1 - 1.7e-36 124.3 0.9 2e-08 34.4 0.0 7.6 2 2 6 8 8 8 8 HEAT repeats HEAT_EZ PF13513.1 EFE39747.1 - 7.2e-13 48.6 10.0 0.00067 20.0 0.0 9.4 8 3 3 11 11 11 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFE39747.1 - 3.4e-12 46.5 2.8 0.00043 20.6 0.1 7.3 6 2 4 10 10 10 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 EFE39747.1 - 1.2e-07 30.4 6.3 2.3e-06 26.2 0.8 3.7 2 1 1 3 3 3 3 Adaptin N terminal region CLASP_N PF12348.3 EFE39747.1 - 0.006 15.9 2.3 1.5 8.1 0.1 4.4 4 2 1 5 5 5 1 CLASP N terminal Arm PF00514.18 EFE39747.1 - 0.0078 15.9 3.4 1.6 8.6 0.0 5.2 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.2 EFE39747.1 - 0.34 10.7 6.7 4.3 7.1 0.2 4.6 4 1 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 B3_4 PF03483.12 EFE39748.1 - 8.7e-25 87.1 0.1 1.7e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 EFE39748.1 - 1.7e-16 59.7 0.0 3.3e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase B5 domain DUF2740 PF10872.3 EFE39748.1 - 0.074 12.7 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) Ribosomal_S3_C PF00189.15 EFE39749.1 - 1.1e-16 60.7 0.0 2.3e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 EFE39749.1 - 2.6e-12 46.1 0.1 4.8e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.3 EFE39749.1 - 0.059 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Myotub-related PF06602.9 EFE39750.1 - 7.7e-121 403.1 0.0 9.8e-121 402.8 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.1 EFE39750.1 - 0.0001 22.5 0.3 0.0025 18.0 0.0 2.3 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 EFE39750.1 - 0.028 13.7 0.0 0.046 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase SLS PF14611.1 EFE39751.1 - 3.4e-54 183.4 0.2 5.3e-54 182.8 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator NT-C2 PF10358.4 EFE39752.1 - 2.2e-25 88.7 0.0 3e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins p450 PF00067.17 EFE39753.1 - 1.3e-20 73.4 0.0 3.6e-13 48.8 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.17 EFE39754.1 - 5.7e-55 186.6 0.0 7.6e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Atg14 PF10186.4 EFE39755.1 - 0.016 14.1 10.0 0.02 13.8 6.9 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Oxysterol_BP PF01237.13 EFE39755.1 - 0.067 11.6 6.1 0.085 11.3 4.3 1.1 1 0 0 1 1 1 0 Oxysterol-binding protein Seryl_tRNA_N PF02403.17 EFE39755.1 - 0.22 11.5 13.2 0.15 12.0 8.2 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.9 EFE39755.1 - 2.3 7.8 11.9 2.9 7.4 8.2 1.1 1 0 0 1 1 1 0 IncA protein Cas_Csy4 PF09618.5 EFE39755.1 - 2.5 7.9 6.6 3.2 7.5 4.6 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) Coiled-coil_56 PF09813.4 EFE39755.1 - 2.5 8.1 9.6 0.96 9.4 4.9 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 HK97-gp10_like PF04883.7 EFE39755.1 - 4 8.4 7.2 6.2 7.8 5.0 1.2 1 0 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component APG6 PF04111.7 EFE39755.1 - 7.1 5.5 13.6 9.1 5.2 9.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 TMPIT PF07851.8 EFE39755.1 - 8.7 5.3 9.6 11 5.0 6.6 1.0 1 0 0 1 1 1 0 TMPIT-like protein Pkinase PF00069.20 EFE39756.1 - 2.2e-09 36.8 0.0 4e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39756.1 - 0.0082 15.2 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE39756.1 - 0.0084 15.8 0.0 0.053 13.2 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFE39756.1 - 0.044 13.1 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Lectin_N PF03954.9 EFE39758.1 - 0.04 13.3 0.1 0.068 12.5 0.0 1.4 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain PolyA_pol_arg_C PF12626.2 EFE39758.1 - 0.13 11.9 0.1 1 8.9 0.0 2.0 2 0 0 2 2 2 0 Polymerase A arginine-rich C-terminus HCMV_UL139 PF12507.3 EFE39758.1 - 0.13 12.4 0.2 0.36 10.9 0.1 1.7 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein Baculo_PEP_C PF04513.7 EFE39758.1 - 0.19 11.5 1.9 0.26 11.1 1.3 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Hce2 PF14856.1 EFE39759.1 - 1.4e-05 24.8 0.1 2.9e-05 23.8 0.0 1.5 2 0 0 2 2 2 1 Pathogen effector; putative necrosis-inducing factor MARVEL PF01284.18 EFE39760.1 - 6.8e-23 81.0 9.5 8.2e-23 80.8 6.6 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF3671 PF12420.3 EFE39760.1 - 0.24 11.4 1.0 4.7 7.2 0.7 2.1 1 1 0 1 1 1 0 Protein of unknown function Fig1 PF12351.3 EFE39760.1 - 1.4 8.7 6.1 2.2 8.1 4.1 1.5 1 1 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 DUF2306 PF10067.4 EFE39760.1 - 5.3 7.2 6.8 6 7.0 1.8 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2306) Pkinase PF00069.20 EFE39761.1 - 6.5e-72 241.7 0.0 8.9e-72 241.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39761.1 - 8.5e-37 126.6 0.0 1.2e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 EFE39761.1 - 1.7e-11 44.0 0.0 3.7e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 EFE39761.1 - 4.8e-06 25.7 0.0 1.9e-05 23.7 0.0 1.8 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.17 EFE39761.1 - 6.2e-05 22.4 0.2 0.00015 21.1 0.1 1.6 1 0 0 1 1 1 1 RIO1 family YukC PF10140.4 EFE39761.1 - 0.0014 17.2 0.1 0.0022 16.6 0.1 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.18 EFE39761.1 - 0.012 15.3 0.4 0.054 13.2 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFE39761.1 - 0.14 10.9 0.5 0.22 10.3 0.4 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 His_Phos_1 PF00300.17 EFE39762.1 - 4.3e-18 65.8 0.0 4.7e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PRELI PF04707.9 EFE39763.1 - 5.3e-23 81.3 0.0 4e-20 71.9 0.0 2.1 2 0 0 2 2 2 2 PRELI-like family UPRTase PF14681.1 EFE39764.1 - 1e-39 135.9 0.7 1.5e-39 135.3 0.5 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.1 EFE39764.1 - 1.4e-08 35.0 0.0 3.2e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 EFE39764.1 - 2.9e-08 33.0 0.0 5.4e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 KAP family P-loop domain HAD PF12710.2 EFE39764.1 - 2.2e-06 27.9 0.0 4.3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AAA_16 PF13191.1 EFE39764.1 - 3.7e-05 23.7 0.1 0.00012 22.0 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain AAA_17 PF13207.1 EFE39764.1 - 0.00013 22.7 0.0 0.00039 21.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFE39764.1 - 0.0018 18.4 0.0 0.014 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE39764.1 - 0.0029 17.4 0.5 0.015 15.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain PRTase_2 PF15609.1 EFE39764.1 - 0.0038 16.5 0.0 0.0073 15.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase Hydrolase PF00702.21 EFE39764.1 - 0.0042 17.5 0.0 0.0087 16.4 0.0 1.6 2 0 0 2 2 1 1 haloacid dehalogenase-like hydrolase Zeta_toxin PF06414.7 EFE39764.1 - 0.0046 16.0 0.1 0.027 13.5 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin Arch_ATPase PF01637.13 EFE39764.1 - 0.0061 16.2 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Archaeal ATPase G-alpha PF00503.15 EFE39764.1 - 0.0061 15.2 0.0 0.0079 14.9 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit NB-ARC PF00931.17 EFE39764.1 - 0.01 14.7 0.0 0.037 12.8 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain SRP54 PF00448.17 EFE39764.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.22 EFE39764.1 - 0.013 15.7 0.0 0.035 14.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Hydrolase_3 PF08282.7 EFE39764.1 - 0.015 14.9 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Pox_A32 PF04665.7 EFE39764.1 - 0.018 14.3 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein cobW PF02492.14 EFE39764.1 - 0.023 14.1 0.1 0.066 12.6 0.1 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 EFE39764.1 - 0.024 14.8 0.0 0.064 13.4 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 EFE39764.1 - 0.029 13.9 0.0 0.059 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EFE39764.1 - 0.037 13.6 0.0 0.074 12.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF258 PF03193.11 EFE39764.1 - 0.038 13.1 0.0 0.1 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 EFE39764.1 - 0.063 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Pribosyltran PF00156.22 EFE39764.1 - 0.066 12.9 1.0 1.2 8.9 0.7 2.6 1 1 0 1 1 1 0 Phosphoribosyl transferase domain SRPRB PF09439.5 EFE39764.1 - 0.07 12.3 0.1 2.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 EFE39764.1 - 0.071 13.0 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFE39764.1 - 0.073 13.0 0.0 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EFE39764.1 - 0.08 12.4 0.0 0.25 10.8 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Methyltransf_23 PF13489.1 EFE39765.1 - 0.0077 15.9 0.1 1.1 8.9 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 EFE39766.1 - 2e-42 145.0 0.0 2.8e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_12 PF08242.7 EFE39766.1 - 3.4e-05 24.2 0.0 5.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE39766.1 - 0.013 16.0 0.0 0.031 14.8 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 EFE39766.1 - 0.047 13.0 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain NAD_binding_4 PF07993.7 EFE39767.1 - 4.1e-58 196.2 0.0 5.9e-58 195.7 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.23 EFE39767.1 - 2e-30 105.5 0.1 3.1e-30 104.9 0.1 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 EFE39767.1 - 1.6e-11 44.2 0.2 3.7e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 EFE39767.1 - 1.9e-10 40.6 0.0 9.2e-10 38.3 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFE39767.1 - 9.7e-06 24.4 0.0 3.9e-05 22.4 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding PF00501.23 EFE39768.1 - 1.9e-36 125.4 0.3 2.2e-36 125.1 0.2 1.0 1 0 0 1 1 1 1 AMP-binding enzyme NmrA PF05368.8 EFE39769.1 - 2.8e-39 134.7 0.0 4e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFE39769.1 - 3.4e-14 53.2 0.0 5.4e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Semialdhyde_dh PF01118.19 EFE39769.1 - 0.00055 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EFE39769.1 - 0.0024 18.2 0.5 0.012 15.9 0.2 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.14 EFE39769.1 - 0.017 13.8 0.0 0.054 12.1 0.0 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFE39769.1 - 0.02 14.3 0.0 0.051 12.9 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family KR PF08659.5 EFE39769.1 - 0.061 12.9 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 KR domain adh_short PF00106.20 EFE39769.1 - 0.08 12.8 0.1 0.45 10.4 0.1 2.0 2 0 0 2 2 2 0 short chain dehydrogenase DapB_N PF01113.15 EFE39769.1 - 0.097 12.5 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus p450 PF00067.17 EFE39770.1 - 9.9e-40 136.4 0.0 1.3e-39 136.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3546 PF12066.3 EFE39770.1 - 0.067 13.2 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3546) DUF4296 PF14129.1 EFE39770.1 - 0.13 12.3 0.1 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) AMP-binding PF00501.23 EFE39771.1 - 7.6e-38 129.9 0.1 1.2e-37 129.2 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 EFE39771.1 - 1.6e-19 69.8 0.0 3.1e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.20 EFE39771.1 - 1.2e-07 31.9 0.2 2.6e-07 30.8 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE39771.1 - 0.055 14.4 0.0 0.15 13.0 0.0 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain PetN PF03742.9 EFE39772.1 - 0.0091 15.5 0.8 0.015 14.8 0.5 1.3 1 0 0 1 1 1 1 PetN adh_short PF00106.20 EFE39773.1 - 4.5e-15 55.9 0.5 7.5e-15 55.2 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE39773.1 - 5.1e-06 26.2 0.1 7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EFE39773.1 - 0.00079 18.4 0.0 0.0011 17.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 EFE39773.1 - 0.034 13.9 0.1 0.077 12.7 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Methyltransf_25 PF13649.1 EFE39774.1 - 9e-13 48.4 0.0 1.8e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE39774.1 - 8.1e-09 35.2 0.0 1.9e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE39774.1 - 3.7e-07 30.5 0.0 8.5e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE39774.1 - 1.3e-06 28.7 0.0 8e-06 26.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE39774.1 - 0.00037 21.0 0.0 0.0008 19.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE39774.1 - 0.00055 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE39774.1 - 0.0029 17.3 0.0 0.0058 16.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Peptidase_M20 PF01546.23 EFE39775.1 - 3.3e-29 101.7 0.0 6e-29 100.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFE39775.1 - 2.8e-12 46.3 0.0 4.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain CobS_N PF12556.3 EFE39775.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Cobaltochelatase CobS subunit N terminal APH PF01636.18 EFE39776.1 - 0.0001 22.1 0.1 0.0001 22.1 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.20 EFE39776.1 - 0.00072 18.7 0.1 0.0012 18.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain HSDR_N_2 PF13588.1 EFE39776.1 - 0.0033 17.2 0.0 1.1 9.0 0.0 2.4 1 1 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) Choline_kinase PF01633.15 EFE39776.1 - 0.0066 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase MRP-L20 PF12824.2 EFE39777.1 - 1.3e-57 194.3 2.6 1.5e-57 194.1 1.8 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.6 EFE39777.1 - 0.011 15.5 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Neugrin Asp_Glu_race PF01177.17 EFE39778.1 - 0.011 15.7 0.1 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Asp/Glu/Hydantoin racemase Tir_receptor_C PF07489.6 EFE39778.1 - 0.1 12.3 5.0 0.25 11.0 3.5 1.6 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.7 EFE39778.1 - 0.61 7.7 3.0 0.84 7.3 2.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.12 EFE39778.1 - 1.5 8.5 15.4 0.19 11.4 6.7 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein SSP160 PF06933.6 EFE39778.1 - 9.6 4.0 12.3 1.5 6.7 5.8 1.5 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 Cys_Met_Meta_PP PF01053.15 EFE39779.1 - 7e-26 90.4 0.0 1.3e-25 89.5 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Nrap PF03813.9 EFE39780.1 - 1.3e-296 986.1 0.0 1.5e-296 985.9 0.0 1.0 1 0 0 1 1 1 1 Nrap protein Fibroin_P25 PF07294.6 EFE39780.1 - 0.052 13.0 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 Fibroin P25 I-set PF07679.11 EFE39781.1 - 0.0082 15.9 0.1 0.3 10.9 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin I-set domain DUF1918 PF08940.6 EFE39781.1 - 0.0085 15.4 0.1 20 4.6 0.0 4.4 4 0 0 4 4 4 2 Domain of unknown function (DUF1918) Peptidase_C12 PF01088.16 EFE39782.1 - 4.3e-62 209.0 0.1 1.7e-61 207.1 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 CG-1 PF03859.11 EFE39782.1 - 0.036 13.5 0.1 0.089 12.3 0.0 1.6 1 1 0 1 1 1 0 CG-1 domain SPX PF03105.14 EFE39783.1 - 1.8e-35 123.0 0.0 2.6e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 SPX domain zf-C3HC4_4 PF15227.1 EFE39783.1 - 1.7e-06 27.7 10.9 1.7e-06 27.7 7.6 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 EFE39783.1 - 2.8e-06 27.0 12.7 5.9e-06 26.0 8.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EFE39783.1 - 1e-05 25.1 10.7 2.5e-05 23.9 7.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFE39783.1 - 1e-05 25.0 10.2 2e-05 24.1 7.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE39783.1 - 1.3e-05 24.7 11.5 3.3e-05 23.4 8.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE39783.1 - 8.7e-05 22.4 12.8 0.00019 21.3 8.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TerY-C PF15616.1 EFE39783.1 - 0.0059 16.5 1.4 0.012 15.5 1.0 1.5 1 0 0 1 1 1 1 TerY-C metal binding domain zf-RING_4 PF14570.1 EFE39783.1 - 0.0079 15.7 3.3 0.0079 15.7 2.3 1.9 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 EFE39783.1 - 0.0082 15.9 3.5 0.018 14.8 2.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EFE39783.1 - 0.038 14.1 5.5 0.097 12.7 3.8 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_UBOX PF13445.1 EFE39783.1 - 0.048 13.3 10.5 0.14 11.8 7.3 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-MIZ PF02891.15 EFE39783.1 - 0.073 12.5 10.3 0.15 11.6 7.2 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Prok-RING_4 PF14447.1 EFE39783.1 - 0.36 10.4 5.0 0.89 9.1 3.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-P11 PF03854.9 EFE39783.1 - 0.57 9.6 8.8 14 5.2 6.3 2.3 1 1 1 2 2 2 0 P-11 zinc finger YccV-like PF08755.6 EFE39784.1 - 2.3e-26 91.6 0.1 6.3e-26 90.2 0.0 1.8 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.1 EFE39784.1 - 3e-14 52.7 0.0 8e-14 51.3 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.2 EFE39784.1 - 8.8e-06 25.3 0.0 2e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE39784.1 - 0.00078 19.0 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 F-box domain 23S_rRNA_IVP PF05635.6 EFE39784.1 - 0.038 13.8 0.1 0.16 11.9 0.0 2.0 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein ACC_epsilon PF13822.1 EFE39785.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.4 4 0 0 4 4 4 0 Acyl-CoA carboxylase epsilon subunit DnaJ PF00226.26 EFE39786.1 - 1.6e-26 91.8 0.3 1.6e-26 91.8 0.2 2.2 2 0 0 2 2 2 1 DnaJ domain zf-met PF12874.2 EFE39786.1 - 1.3e-12 47.4 7.5 3.3e-09 36.6 1.7 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EFE39786.1 - 7.4e-12 45.0 9.8 1.4e-09 37.7 3.6 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EFE39786.1 - 4.8e-10 39.4 6.4 0.00023 21.2 1.3 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 EFE39786.1 - 4.1e-07 29.9 6.6 0.0052 17.0 0.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE39786.1 - 1.2e-05 25.3 4.1 0.046 14.0 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EFE39786.1 - 0.00024 20.8 8.2 0.024 14.5 0.3 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger LIM PF00412.17 EFE39786.1 - 0.0085 16.1 2.1 0.6 10.2 0.3 2.4 2 0 0 2 2 2 1 LIM domain zf-BED PF02892.10 EFE39786.1 - 0.026 14.2 0.2 3.8 7.3 0.1 2.4 2 0 0 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.1 EFE39786.1 - 0.12 12.6 2.0 2.1 8.7 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger double domain R3H PF01424.17 EFE39787.1 - 7.6e-11 41.5 0.0 1.8e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 R3H domain G-patch PF01585.18 EFE39787.1 - 3.6e-09 36.2 0.3 8.9e-09 35.0 0.2 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 EFE39787.1 - 0.0034 17.2 0.2 0.0034 17.2 0.1 3.6 5 0 0 5 5 5 1 DExH-box splicing factor binding site Peptidase_S49_N PF08496.5 EFE39787.1 - 0.0049 16.6 5.7 0.0049 16.6 4.0 3.0 3 0 0 3 3 3 1 Peptidase family S49 N-terminal Peptidase_C54 PF03416.14 EFE39788.1 - 8.5e-63 212.0 0.0 2.8e-62 210.3 0.0 1.8 2 1 0 2 2 2 1 Peptidase family C54 Dicty_REP PF05086.7 EFE39788.1 - 1.4 6.6 8.0 1.8 6.2 5.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_C54 PF03416.14 EFE39789.1 - 0.042 12.9 0.0 0.075 12.1 0.0 1.4 2 0 0 2 2 2 0 Peptidase family C54 Sec31 PF11549.3 EFE39789.1 - 0.051 13.2 0.0 0.069 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein transport protein SEC31 Histone PF00125.19 EFE39790.1 - 3.8e-20 71.7 0.3 5.3e-20 71.3 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFE39790.1 - 5.3e-05 23.1 0.1 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 EFE39790.1 - 0.0025 18.0 0.0 0.0041 17.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.8 EFE39790.1 - 0.029 13.8 0.1 0.041 13.3 0.1 1.2 1 0 0 1 1 1 0 Replication protein C N-terminal domain DUF3915 PF13054.1 EFE39790.1 - 0.053 13.4 0.0 0.068 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF1018 PF06252.7 EFE39790.1 - 0.083 13.4 0.2 0.11 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Histone PF00125.19 EFE39791.1 - 9.7e-24 83.2 0.0 1.5e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFE39791.1 - 9.6e-06 25.5 0.0 0.00018 21.5 0.0 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone 2-oxoacid_dh PF00198.18 EFE39793.1 - 1.1e-80 270.2 0.0 1.6e-80 269.7 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EFE39793.1 - 6.9e-14 51.2 1.1 6.9e-14 51.2 0.7 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme HlyD_2 PF12700.2 EFE39793.1 - 0.0013 17.9 3.6 0.018 14.2 0.6 2.5 1 1 1 2 2 2 1 HlyD family secretion protein GCV_H PF01597.14 EFE39793.1 - 0.077 12.6 0.3 0.19 11.4 0.2 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF3614 PF12267.3 EFE39793.1 - 0.16 12.2 1.4 0.2 11.8 0.0 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3614) FAP PF07174.6 EFE39793.1 - 0.21 10.8 13.3 0.32 10.2 9.2 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Neisseria_TspB PF05616.8 EFE39793.1 - 0.89 7.8 10.8 1.3 7.3 7.5 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF4551 PF15087.1 EFE39793.1 - 1.3 7.2 4.8 1.7 6.9 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Drc1-Sld2 PF11719.3 EFE39794.1 - 2.8e-83 280.4 23.5 3.2e-83 280.2 16.3 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein zf-RING_2 PF13639.1 EFE39795.1 - 3e-08 33.3 8.0 5.2e-08 32.5 5.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFE39795.1 - 6.6e-06 26.0 9.5 1.1e-05 25.3 6.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE39795.1 - 2.3e-05 23.9 7.8 3.6e-05 23.3 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE39795.1 - 9.2e-05 22.0 8.3 0.00016 21.2 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFE39795.1 - 0.0067 16.5 9.8 0.024 14.7 6.8 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EFE39795.1 - 0.32 10.7 5.2 0.59 9.9 3.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Toxin_41 PF15521.1 EFE39796.1 - 0.058 12.5 0.1 0.06 12.5 0.1 1.0 1 0 0 1 1 1 0 Putative toxin 41 DUF2410 PF10307.4 EFE39797.1 - 2.6e-51 173.8 0.0 3.5e-51 173.4 0.0 1.2 1 0 0 1 1 1 1 Hypothetical protein (DUF2410) SWIRM PF04433.12 EFE39798.1 - 2.4e-15 56.4 0.1 9.7e-15 54.4 0.0 1.9 2 0 0 2 2 2 1 SWIRM domain CDC50 PF03381.10 EFE39799.1 - 2.6e-98 328.5 0.0 3.6e-98 328.1 0.0 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family SPT16 PF08644.6 EFE39800.1 - 3e-59 199.2 0.1 7.9e-59 197.8 0.0 1.8 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 EFE39800.1 - 9.7e-55 184.5 0.1 3.1e-54 182.8 0.1 2.0 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 EFE39800.1 - 1.6e-24 86.6 0.0 2.5e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 EFE39800.1 - 3.4e-19 68.6 0.0 9.4e-19 67.1 0.0 1.8 1 0 0 1 1 1 1 Histone chaperone Rttp106-like RST PF12174.3 EFE39800.1 - 0.19 11.5 1.2 0.42 10.4 0.8 1.5 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain Mito_carr PF00153.22 EFE39801.1 - 2.2e-15 56.1 0.2 6.3e-12 45.0 0.0 3.2 3 0 0 3 3 3 2 Mitochondrial carrier protein SR-25 PF10500.4 EFE39802.1 - 6.3 6.2 7.5 7.7 5.9 5.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GST_N_3 PF13417.1 EFE39803.1 - 1.8e-08 34.4 0.0 4.2e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE39803.1 - 2.7e-07 30.4 0.1 7.9e-07 28.9 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE39803.1 - 5.7e-06 26.1 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE39803.1 - 0.00015 22.1 0.1 0.00025 21.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFE39803.1 - 0.00026 20.9 0.0 0.00049 20.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DBD_Tnp_Hermes PF10683.4 EFE39803.1 - 0.029 13.8 0.0 0.075 12.5 0.0 1.7 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain DUF2981 PF11200.3 EFE39804.1 - 7 5.6 6.6 7.2 5.5 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Sugar_tr PF00083.19 EFE39805.1 - 7.4e-97 324.7 9.2 9.2e-97 324.4 6.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE39805.1 - 1.7e-30 105.9 20.5 3.5e-30 104.8 10.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE39805.1 - 7.1e-12 44.4 11.1 7.7e-07 27.8 0.6 3.0 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.2 EFE39805.1 - 0.0098 15.6 0.5 0.05 13.3 0.0 2.3 2 0 0 2 2 2 1 MFS_1 like family DUF1315 PF07023.7 EFE39806.1 - 0.065 13.1 0.7 0.065 13.1 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1315) DUF2796 PF10986.3 EFE39806.1 - 2.6 7.9 7.8 3.3 7.6 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Nop14 PF04147.7 EFE39806.1 - 9.9 3.9 24.8 11 3.7 17.2 1.0 1 0 0 1 1 1 0 Nop14-like family PMT PF02366.13 EFE39807.1 - 2.6e-84 282.4 15.9 2.6e-84 282.4 11.0 2.7 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EFE39807.1 - 6.7e-39 133.3 0.1 9.2e-39 132.9 0.1 1.2 1 0 0 1 1 1 1 MIR domain Ras PF00071.17 EFE39810.1 - 1.4e-36 125.3 0.0 2.3e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE39810.1 - 9.2e-11 42.2 0.0 2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE39810.1 - 8.2e-08 31.6 0.1 1.9e-07 30.4 0.1 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFE39810.1 - 3.2e-07 29.9 0.0 4.1e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFE39810.1 - 2.3e-05 23.6 0.0 3.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF2201_N PF13203.1 EFE39810.1 - 0.049 12.8 0.1 0.069 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain FAM176 PF14851.1 EFE39810.1 - 0.26 10.9 3.2 0.44 10.2 2.2 1.2 1 0 0 1 1 1 0 FAM176 family Choline_transpo PF04515.7 EFE39812.1 - 7.5e-13 47.9 15.6 7.5e-13 47.9 10.8 3.0 3 0 0 3 3 3 2 Plasma-membrane choline transporter EF-hand_8 PF13833.1 EFE39815.1 - 4.1e-30 103.1 5.8 1.3e-12 47.1 0.0 3.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 EFE39815.1 - 3.9e-27 91.4 8.4 4e-09 35.1 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.1 EFE39815.1 - 1.4e-25 89.2 1.8 3.4e-16 59.1 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EFE39815.1 - 4e-18 63.6 6.5 1.3e-08 34.0 0.0 4.9 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.1 EFE39815.1 - 2.3e-16 58.2 2.7 7.3e-06 25.0 0.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 EFE39815.1 - 1.2e-09 37.9 0.1 0.00035 20.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.8 EFE39815.1 - 1.5e-07 30.9 0.2 0.033 13.7 0.0 3.2 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.2 EFE39815.1 - 6e-07 29.1 0.5 0.015 15.0 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.5 EFE39815.1 - 0.00062 19.6 0.6 0.0019 18.1 0.0 2.1 3 0 0 3 3 3 1 Ca2+ insensitive EF hand SPARC_Ca_bdg PF10591.4 EFE39815.1 - 0.00086 19.3 0.1 0.18 11.8 0.0 2.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region RNA_pol_Rpb4 PF03874.11 EFE39815.1 - 0.0032 17.4 0.2 2.3 8.2 0.0 2.4 2 0 0 2 2 2 2 RNA polymerase Rpb4 Tenui_NCP PF04876.7 EFE39815.1 - 0.073 12.6 0.0 0.25 10.8 0.0 1.8 1 1 1 2 2 2 0 Tenuivirus major non-capsid protein Med20 PF08612.6 EFE39816.1 - 6.2e-55 185.7 0.0 7.9e-55 185.4 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Peptidase_A17 PF05380.8 EFE39816.1 - 0.061 13.1 0.1 1.8 8.3 0.0 2.2 2 0 0 2 2 2 0 Pao retrotransposon peptidase FAD_binding_1 PF00667.15 EFE39817.1 - 1.9e-44 151.7 0.0 2.9e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 EFE39817.1 - 1.4e-09 38.4 0.0 5.1e-09 36.6 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain ChaC PF04752.7 EFE39818.1 - 2.7e-28 99.1 0.0 5.1e-28 98.2 0.0 1.4 1 1 0 1 1 1 1 ChaC-like protein RRM_1 PF00076.17 EFE39819.1 - 1.2e-15 56.8 0.1 5.2e-15 54.8 0.1 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE39819.1 - 9.4e-11 41.5 0.0 1.6e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39819.1 - 6.1e-06 25.9 1.7 0.00026 20.7 0.1 3.1 3 1 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glucosaminidase PF01832.15 EFE39819.1 - 0.029 14.4 0.6 0.058 13.5 0.0 1.7 2 1 0 2 2 2 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase FHA PF00498.21 EFE39820.1 - 1.9e-09 37.4 0.2 3.4e-09 36.6 0.1 1.4 1 0 0 1 1 1 1 FHA domain Helicase_IV_N PF12462.3 EFE39821.1 - 0.55 9.8 10.7 1.1 8.8 7.4 1.4 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Methyltransf_23 PF13489.1 EFE39822.1 - 1.6e-11 44.2 0.0 3e-11 43.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE39822.1 - 0.0048 16.4 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain ApoO PF09769.4 EFE39823.1 - 0.014 15.1 0.3 0.15 11.7 0.0 2.2 2 0 0 2 2 2 0 Apolipoprotein O DUF2321 PF10083.4 EFE39823.1 - 0.15 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) CAF1A PF12253.3 EFE39824.1 - 3.8e-25 87.7 5.2 3.8e-25 87.7 3.6 4.1 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.3 EFE39824.1 - 1.3e-19 70.4 53.2 1.3e-19 70.4 36.9 2.1 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal MIP-T3 PF10243.4 EFE39824.1 - 0.0013 17.2 50.3 0.0027 16.2 34.9 1.5 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Raftlin PF15250.1 EFE39824.1 - 0.1 11.1 16.1 0.16 10.4 11.2 1.4 1 0 0 1 1 1 0 Raftlin SAPS PF04499.10 EFE39824.1 - 0.16 10.6 12.6 0.27 9.8 8.7 1.5 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.7 EFE39824.1 - 0.29 9.0 38.3 1.1 7.0 0.7 2.1 2 0 0 2 2 2 0 Nop14-like family Asp-B-Hydro_N PF05279.6 EFE39824.1 - 0.33 10.7 36.6 0.68 9.7 25.3 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Mem_trans PF03547.13 EFE39824.1 - 0.56 8.4 4.2 0.94 7.6 2.9 1.5 1 0 0 1 1 1 0 Membrane transport protein SprA-related PF12118.3 EFE39824.1 - 2.6 7.2 37.1 0.29 10.4 22.7 1.7 2 0 0 2 2 2 0 SprA-related family BAR PF03114.13 EFE39825.1 - 0.022 14.3 0.7 0.14 11.6 0.8 2.1 2 0 0 2 2 2 0 BAR domain Dicty_REP PF05086.7 EFE39825.1 - 9.3 3.8 5.9 15 3.2 4.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein IPP-2 PF04979.9 EFE39826.1 - 2.9e-09 37.2 18.0 3.6e-06 27.2 2.0 2.7 1 1 1 2 2 2 2 Protein phosphatase inhibitor 2 (IPP-2) PAPA-1 PF04795.7 EFE39826.1 - 0.098 13.3 0.2 0.098 13.3 0.1 2.5 3 0 0 3 3 3 0 PAPA-1-like conserved region CRAL_TRIO PF00650.15 EFE39828.1 - 2.6e-13 49.7 0.1 4.2e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFE39828.1 - 3.8e-05 23.7 0.4 0.00014 21.9 0.0 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CDC45 PF02724.9 EFE39828.1 - 1.2 7.0 5.4 16 3.3 3.5 2.0 2 0 0 2 2 2 0 CDC45-like protein DUF1546 PF07571.8 EFE39829.1 - 8.1e-33 112.4 0.0 2.1e-32 111.0 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1546) TAF PF02969.12 EFE39829.1 - 4.5e-25 87.3 0.0 1.9e-24 85.3 0.0 2.1 3 0 0 3 3 3 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 EFE39829.1 - 0.00033 20.7 0.0 0.0013 18.8 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 EFE39829.1 - 0.013 15.1 0.0 0.035 13.8 0.0 1.7 1 0 0 1 1 1 0 Bromodomain associated TAF4 PF05236.9 EFE39829.1 - 0.051 12.8 0.0 0.077 12.2 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CBFD_NFYB_HMF PF00808.18 EFE39829.1 - 0.056 13.5 0.0 0.2 11.7 0.0 2.0 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 EFE39829.1 - 0.14 11.9 0.1 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit SAM_decarbox PF01536.11 EFE39830.1 - 7.8e-87 291.0 0.0 5.5e-86 288.2 0.0 2.2 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase Pkinase PF00069.20 EFE39832.1 - 6.8e-41 140.1 0.0 3.6e-40 137.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39832.1 - 6.7e-23 81.0 0.0 1e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE39832.1 - 0.007 16.1 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EFE39832.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.6 EFE39832.1 - 0.65 8.7 0.1 0.92 8.2 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase AMP-binding PF00501.23 EFE39833.1 - 4.3e-238 789.6 0.1 2.8e-88 296.1 0.0 4.4 3 1 1 4 4 4 4 AMP-binding enzyme Condensation PF00668.15 EFE39833.1 - 9.6e-184 609.1 0.0 4.8e-37 127.4 0.0 6.4 6 0 0 6 6 6 6 Condensation domain PP-binding PF00550.20 EFE39833.1 - 3.5e-55 184.1 19.1 2.8e-09 37.1 0.1 7.0 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE39833.1 - 1.1e-21 77.5 0.0 2e-07 31.8 0.0 4.0 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain HxxPF_rpt PF13745.1 EFE39833.1 - 2e-06 28.0 0.7 0.044 14.1 0.0 3.8 3 0 0 3 3 3 2 HxxPF-repeated domain WES_acyltransf PF03007.11 EFE39833.1 - 0.18 11.3 0.4 66 2.9 0.0 3.9 4 0 0 4 4 4 0 Wax ester synthase-like Acyl-CoA acyltransferase domain K_oxygenase PF13434.1 EFE39834.1 - 3.1e-106 355.1 0.0 3.8e-106 354.8 0.0 1.1 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EFE39834.1 - 8.2e-11 41.9 0.0 8.9e-09 35.3 0.0 2.4 2 1 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EFE39834.1 - 1.6e-08 34.8 0.0 6.1e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE39834.1 - 4.5e-07 29.9 0.0 0.0028 17.5 0.0 3.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Ank_2 PF12796.2 EFE39835.1 - 1.1e-41 141.0 0.0 1.5e-18 66.9 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) zf-DHHC PF01529.15 EFE39835.1 - 3.7e-38 130.6 6.7 3.7e-38 130.6 4.7 2.3 1 1 1 2 2 2 1 DHHC palmitoyltransferase Ank PF00023.25 EFE39835.1 - 7e-34 113.9 0.7 3.8e-10 39.0 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 EFE39835.1 - 3.6e-26 90.5 0.9 7.2e-08 32.4 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE39835.1 - 2.9e-23 81.8 1.0 6.1e-08 32.9 0.0 4.5 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE39835.1 - 4.7e-23 78.9 2.8 8.4e-08 31.7 0.0 6.5 7 0 0 7 7 7 4 Ankyrin repeat FCP1_C PF09309.5 EFE39835.1 - 0.28 10.4 0.2 0.43 9.8 0.1 1.1 1 0 0 1 1 1 0 FCP1, C-terminal OB_NTP_bind PF07717.11 EFE39836.1 - 1.4e-29 102.1 0.0 3.9e-29 100.7 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFE39836.1 - 1e-25 89.7 0.0 1.3e-24 86.1 0.0 2.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE39836.1 - 1.4e-12 47.2 0.0 3.6e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE39836.1 - 2.4e-05 23.8 0.1 5.5e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase PWI PF01480.12 EFE39836.1 - 0.00011 22.1 0.0 0.00029 20.8 0.0 1.7 1 0 0 1 1 1 1 PWI domain AAA_22 PF13401.1 EFE39836.1 - 0.00013 22.1 0.0 0.00049 20.2 0.0 2.0 2 0 0 2 2 1 1 AAA domain T2SE PF00437.15 EFE39836.1 - 0.00036 19.5 0.0 0.00075 18.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Sigma54_activ_2 PF14532.1 EFE39836.1 - 0.0095 15.9 0.0 0.031 14.3 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain SRP54 PF00448.17 EFE39836.1 - 0.034 13.5 0.0 0.077 12.4 0.0 1.7 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.1 EFE39836.1 - 0.046 13.4 0.5 0.16 11.7 0.1 2.1 2 0 0 2 2 2 0 Part of AAA domain AAA_29 PF13555.1 EFE39836.1 - 0.09 12.3 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 EFE39836.1 - 0.19 12.0 0.0 0.19 12.0 0.0 3.2 1 1 1 2 2 1 0 AAA domain ABC_tran PF00005.22 EFE39836.1 - 1 9.6 4.2 0.43 10.8 0.1 2.4 2 1 1 3 3 3 0 ABC transporter Cyt-b5 PF00173.23 EFE39837.1 - 6e-18 64.4 0.1 6.7e-18 64.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4291 PF14124.1 EFE39838.1 - 8.4e-76 253.6 0.1 9.6e-76 253.4 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) Mcp5_PH PF12814.2 EFE39839.1 - 3.7e-49 165.7 0.0 9.1e-49 164.4 0.0 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology DUF3584 PF12128.3 EFE39839.1 - 0.051 10.9 11.1 0.07 10.4 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.7 EFE39839.1 - 9.1 6.0 15.7 0.7 9.6 3.3 2.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein MFS_1 PF07690.11 EFE39840.1 - 9.5e-10 37.7 34.3 9.5e-10 37.7 23.8 4.3 2 2 1 3 3 3 2 Major Facilitator Superfamily Chloroa_b-bind PF00504.16 EFE39840.1 - 0.37 11.0 2.6 0.34 11.1 0.1 2.2 2 0 0 2 2 2 0 Chlorophyll A-B binding protein Ribonuc_red_lgC PF02867.10 EFE39841.1 - 8.5e-215 714.3 0.0 1.3e-214 713.7 0.0 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 EFE39841.1 - 8.2e-26 89.6 0.0 1.8e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 EFE39841.1 - 3e-13 49.9 0.1 1.2e-12 48.1 0.0 2.1 2 0 0 2 2 2 1 ATP cone domain MSP1_C PF07462.6 EFE39842.1 - 0.73 8.1 2.8 0.97 7.7 1.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Mucin PF01456.12 EFE39842.1 - 6.5 6.5 12.5 13 5.5 8.7 1.7 1 1 0 1 1 1 0 Mucin-like glycoprotein AAA_17 PF13207.1 EFE39843.1 - 5.5e-06 27.2 0.2 3.5e-05 24.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFE39843.1 - 9.5e-05 22.7 0.1 0.012 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 EFE39843.1 - 0.0011 18.5 0.0 0.0015 18.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.1 EFE39843.1 - 0.0017 18.2 0.3 0.13 12.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFE39843.1 - 0.003 17.7 0.0 0.0046 17.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFE39843.1 - 0.006 16.5 0.0 0.013 15.5 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.7 EFE39843.1 - 0.007 15.4 1.3 0.32 10.0 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 EFE39843.1 - 0.011 15.5 0.1 0.021 14.5 0.1 1.6 1 0 0 1 1 1 0 Part of AAA domain Thymidylate_kin PF02223.12 EFE39843.1 - 0.012 15.0 0.0 0.98 8.7 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase NB-ARC PF00931.17 EFE39843.1 - 0.048 12.5 0.1 0.069 12.0 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain APS_kinase PF01583.15 EFE39843.1 - 0.14 11.7 0.0 0.3 10.7 0.0 1.5 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_22 PF13401.1 EFE39843.1 - 0.16 12.1 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain FAM163 PF15069.1 EFE39844.1 - 0.48 10.9 2.1 0.38 11.3 0.3 1.6 2 0 0 2 2 2 0 FAM163 family TFIIA PF03153.8 EFE39844.1 - 0.62 9.9 10.2 0.93 9.3 6.9 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mur_ligase_M PF08245.7 EFE39845.1 - 8.1e-08 32.5 0.2 1.8e-07 31.3 0.2 1.7 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 EFE39845.1 - 0.054 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain TP_methylase PF00590.15 EFE39845.1 - 0.25 11.0 5.0 20 4.7 0.8 3.7 4 0 0 4 4 4 0 Tetrapyrrole (Corrin/Porphyrin) Methylases Pkinase PF00069.20 EFE39846.1 - 8.4e-55 185.7 0.0 2.8e-54 184.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39846.1 - 1.9e-39 135.2 0.0 5e-39 133.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE39846.1 - 0.0071 15.3 0.0 0.017 14.1 0.0 1.6 1 0 0 1 1 1 1 Kinase-like HEAT PF02985.17 EFE39846.1 - 0.052 13.6 0.4 1.2e+02 3.2 0.0 4.8 5 0 0 5 5 5 0 HEAT repeat Peptidase_M24 PF00557.19 EFE39847.1 - 5.1e-45 153.5 0.1 6.1e-45 153.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 FAA_hydrolase PF01557.13 EFE39847.1 - 0.002 17.6 0.0 0.0033 16.9 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family TRAP_alpha PF03896.11 EFE39847.1 - 0.12 11.3 2.4 0.18 10.7 1.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TATR PF03430.8 EFE39847.1 - 0.14 10.7 3.8 0.18 10.3 2.7 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Cnd2 PF05786.9 EFE39847.1 - 0.91 7.9 9.9 1.4 7.3 6.9 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 CDC45 PF02724.9 EFE39847.1 - 1.1 7.1 5.9 1.6 6.6 4.1 1.1 1 0 0 1 1 1 0 CDC45-like protein PGA2 PF07543.7 EFE39847.1 - 4.2 7.1 9.1 8.4 6.1 6.3 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 DnaJ PF00226.26 EFE39848.1 - 5.1e-13 48.5 0.6 8.6e-13 47.8 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain Porin_3 PF01459.17 EFE39849.1 - 6.5e-62 209.2 3.7 8e-62 209.0 2.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin KdpC PF02669.10 EFE39849.1 - 0.056 13.1 0.6 0.094 12.4 0.4 1.3 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Asn_synthase PF00733.16 EFE39851.1 - 6.2e-66 222.4 0.0 8.5e-66 222.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 EFE39851.1 - 1.9e-35 121.3 0.0 4e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EFE39851.1 - 4.4e-27 94.6 0.0 8e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 EFE39851.1 - 6.7e-08 32.0 0.0 1.3e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.12 EFE39851.1 - 0.00059 18.8 0.1 0.0052 15.7 0.0 2.0 1 1 0 1 1 1 1 NAD synthase GATase_2 PF00310.16 EFE39851.1 - 0.022 13.4 0.0 0.28 9.8 0.0 2.3 1 1 2 3 3 3 0 Glutamine amidotransferases class-II G-patch PF01585.18 EFE39852.1 - 5.7e-12 45.2 1.5 1.1e-11 44.3 1.0 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 EFE39852.1 - 0.017 14.9 0.4 0.052 13.3 0.3 1.9 1 0 0 1 1 1 0 DExH-box splicing factor binding site AMP-binding PF00501.23 EFE39853.1 - 4.9e-87 292.0 0.0 5.8e-87 291.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE39853.1 - 1.2e-06 29.4 0.0 3.3e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.8 EFE39853.1 - 0.00017 20.2 0.1 0.0041 15.7 0.0 2.6 3 0 0 3 3 3 1 GH3 auxin-responsive promoter Fungal_trans PF04082.13 EFE39854.1 - 1.2e-18 66.9 2.5 2.2e-18 66.0 1.7 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.3 EFE39855.1 - 1.1e-09 37.4 0.0 4e-09 35.5 0.0 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain Rad10 PF03834.9 EFE39856.1 - 3.9e-31 106.5 0.0 5.9e-31 105.9 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.1 EFE39856.1 - 0.00013 22.1 0.0 0.00029 20.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 EFE39856.1 - 0.03 14.1 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH PF00633.18 EFE39856.1 - 0.037 13.7 0.0 0.084 12.6 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif RRM_1 PF00076.17 EFE39857.1 - 2.5e-60 200.0 0.0 5.8e-19 67.5 0.0 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE39857.1 - 4.5e-42 141.8 0.0 1.8e-12 47.0 0.0 5.1 5 0 0 5 5 5 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE39857.1 - 2.7e-22 78.3 0.0 3.3e-06 26.8 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NosL PF05573.7 EFE39857.1 - 0.046 13.4 0.1 0.58 9.8 0.0 2.2 2 0 0 2 2 2 0 NosL Cyt-b5 PF00173.23 EFE39858.1 - 3.1e-09 36.4 0.0 3.7e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AA_permease PF00324.16 EFE39859.1 - 1.1e-90 304.2 28.5 1.4e-90 303.9 19.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE39859.1 - 4.3e-14 51.8 30.1 5.6e-14 51.5 20.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.6 EFE39859.1 - 0.0024 17.6 3.0 0.0024 17.6 2.1 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF1772) Cupin_8 PF13621.1 EFE39860.1 - 1.7e-21 76.8 0.0 6.6e-21 74.9 0.0 1.7 2 0 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.7 EFE39860.1 - 2.3e-05 23.7 0.0 5.1e-05 22.6 0.0 1.5 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_2 PF07883.6 EFE39860.1 - 0.007 15.8 0.0 0.022 14.2 0.0 1.9 2 0 0 2 2 2 1 Cupin domain JmjC PF02373.17 EFE39860.1 - 0.013 15.7 0.1 0.057 13.6 0.0 2.1 3 0 0 3 3 3 0 JmjC domain, hydroxylase Fungal_trans PF04082.13 EFE39861.1 - 1.4e-18 66.7 0.0 2.8e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain PsbT PF01405.12 EFE39861.1 - 0.53 9.9 2.2 1.1 8.8 1.6 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre T protein CK_II_beta PF01214.13 EFE39862.1 - 1.3e-74 249.7 0.0 3.7e-74 248.2 0.0 1.7 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Spt5_N PF11942.3 EFE39862.1 - 0.059 13.9 10.4 0.065 13.8 5.1 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Myc_N PF01056.13 EFE39862.1 - 0.25 10.4 4.1 1.1 8.4 2.1 2.0 2 0 0 2 2 2 0 Myc amino-terminal region NTR2 PF15458.1 EFE39862.1 - 0.26 10.4 6.0 0.48 9.6 4.1 1.3 1 0 0 1 1 1 0 Nineteen complex-related protein 2 Sigma70_ner PF04546.8 EFE39862.1 - 0.47 10.0 5.0 0.072 12.7 0.8 1.5 2 0 0 2 2 2 0 Sigma-70, non-essential region Nucleoplasmin PF03066.10 EFE39862.1 - 1.7 8.1 7.7 0.53 9.7 3.1 1.7 2 0 0 2 2 2 0 Nucleoplasmin Aminotran_4 PF01063.14 EFE39864.1 - 1.3e-22 80.4 0.0 1.5e-22 80.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class IV Ank_2 PF12796.2 EFE39865.1 - 6.9e-40 135.2 9.8 1.2e-12 47.9 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE39865.1 - 5.7e-29 99.9 5.8 8.7e-10 38.8 0.0 5.9 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.25 EFE39865.1 - 3.9e-24 83.2 10.1 0.00085 19.0 0.0 8.5 8 0 0 8 8 8 6 Ankyrin repeat SPX PF03105.14 EFE39865.1 - 8.1e-21 75.0 4.9 3.2e-17 63.2 3.4 2.7 1 1 0 1 1 1 1 SPX domain Ank_3 PF13606.1 EFE39865.1 - 3.1e-18 64.0 5.4 0.0016 18.5 0.0 7.8 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.1 EFE39865.1 - 6.2e-14 51.6 9.1 0.0019 18.3 0.0 6.3 3 1 4 7 7 7 6 Ankyrin repeats (many copies) GDPD PF03009.12 EFE39865.1 - 6.5e-13 48.7 0.0 2e-12 47.1 0.0 1.8 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ebp2 PF05890.7 EFE39865.1 - 0.32 10.2 3.3 0.58 9.4 2.3 1.3 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 Pkinase PF00069.20 EFE39866.1 - 1.7e-17 63.4 0.0 4.4e-17 62.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39866.1 - 2.2e-09 36.7 0.0 6.5e-09 35.2 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Peptidase_M49 PF03571.10 EFE39867.1 - 8.7e-230 763.4 0.0 1.4e-229 762.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M49 LEA_1 PF03760.10 EFE39868.1 - 7.3 6.8 8.0 0.49 10.5 1.9 1.7 2 0 0 2 2 2 0 Late embryogenesis abundant (LEA) group 1 SNF5 PF04855.7 EFE39870.1 - 1.4e-80 270.2 0.0 1.9e-80 269.9 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 BHD_1 PF10403.4 EFE39871.1 - 0.081 12.4 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 1 WD40 PF00400.27 EFE39872.1 - 1.4e-40 135.7 24.1 3e-13 49.0 0.5 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 EFE39872.1 - 1.3e-06 28.2 13.7 0.0038 16.9 1.8 4.0 2 1 2 5 5 5 2 Transcription factor IIIC subunit delta N-term SNARE PF05739.14 EFE39873.1 - 8.5e-16 57.3 1.2 8.5e-16 57.3 0.8 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 EFE39873.1 - 1.5e-10 41.1 3.9 2e-10 40.7 0.2 2.5 2 0 0 2 2 2 1 Syntaxin MCPsignal PF00015.16 EFE39873.1 - 0.012 15.1 0.7 0.012 15.1 0.5 2.4 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CTD_bind PF04818.8 EFE39874.1 - 5.7e-20 71.3 0.1 1.2e-19 70.2 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Clathrin_lg_ch PF01086.12 EFE39875.1 - 8.3e-70 235.2 4.2 9.5e-70 235.0 2.9 1.0 1 0 0 1 1 1 1 Clathrin light chain ATP-synt_B PF00430.13 EFE39875.1 - 1.8 8.3 7.3 2.9 7.6 5.0 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Acyl_transf_3 PF01757.17 EFE39876.1 - 6.9e-23 81.0 34.0 9.8e-23 80.5 23.6 1.2 1 0 0 1 1 1 1 Acyltransferase family Mannosyl_trans3 PF11051.3 EFE39877.1 - 3.4e-70 236.4 0.0 9.9e-70 234.9 0.0 1.7 1 1 0 1 1 1 1 Mannosyltransferase putative CDC37_N PF03234.9 EFE39878.1 - 1.4e-60 204.6 5.5 1.4e-60 204.6 3.8 2.5 2 1 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 EFE39878.1 - 2.9e-46 157.1 0.6 7.1e-46 155.8 0.0 1.9 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 EFE39878.1 - 1.2e-26 92.4 2.4 1.2e-26 92.4 1.7 2.3 2 0 0 2 2 2 1 Cdc37 C terminal domain MecA_N PF05223.6 EFE39878.1 - 0.014 15.4 1.1 0.014 15.4 0.7 2.5 3 0 0 3 3 3 0 NTF2-like N-terminal transpeptidase domain DUF77 PF01910.12 EFE39878.1 - 0.051 13.2 0.3 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF77 DUF3287 PF11690.3 EFE39878.1 - 1.8 8.6 5.5 7.8 6.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3287) ABC_membrane PF00664.18 EFE39879.1 - 3.1e-45 154.7 11.6 3.9e-45 154.3 8.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 EFE39879.1 - 3.1e-35 121.4 0.0 8.3e-35 120.0 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 EFE39879.1 - 7.1e-07 28.6 0.1 4.9e-05 22.6 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EFE39879.1 - 0.00027 20.9 0.1 0.00027 20.9 0.1 2.6 3 1 0 3 3 2 1 AAA ATPase domain AAA_21 PF13304.1 EFE39879.1 - 0.0004 20.4 0.2 0.83 9.5 0.1 2.4 1 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFE39879.1 - 0.0009 19.3 0.1 0.0055 16.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFE39879.1 - 0.0016 17.9 0.6 0.0036 16.8 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.1 EFE39879.1 - 0.0051 17.6 0.0 0.012 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EFE39879.1 - 0.0056 16.1 0.4 0.056 12.8 0.3 2.2 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EFE39879.1 - 0.01 15.2 0.1 0.12 11.8 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA PF00004.24 EFE39879.1 - 0.012 15.7 0.0 0.066 13.4 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 EFE39879.1 - 0.012 15.0 0.7 0.07 12.5 0.2 2.1 2 0 0 2 2 2 0 AAA-like domain ABC_ATPase PF09818.4 EFE39879.1 - 0.014 14.0 0.6 0.058 11.9 0.1 1.9 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Sigma54_activ_2 PF14532.1 EFE39879.1 - 0.049 13.6 0.1 0.27 11.2 0.0 2.3 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_18 PF13238.1 EFE39879.1 - 0.067 13.5 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 EFE39879.1 - 0.072 12.2 0.0 0.16 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 EFE39879.1 - 0.1 12.2 0.1 0.68 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 EFE39879.1 - 0.57 10.1 4.6 0.39 10.6 0.4 2.8 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit Nucleoside_tran PF01733.13 EFE39880.1 - 5.1e-40 137.5 14.0 9.9e-39 133.3 8.1 2.8 1 1 1 2 2 2 1 Nucleoside transporter MFS_1 PF07690.11 EFE39880.1 - 1.3e-06 27.4 32.5 1.1e-05 24.2 20.6 2.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF843 PF05814.6 EFE39880.1 - 0.1 12.4 2.2 0.51 10.1 0.1 2.6 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) OST3_OST6 PF04756.8 EFE39880.1 - 8.6 5.8 9.6 1.4 8.4 0.8 3.2 2 2 1 3 3 3 0 OST3 / OST6 family Metallophos_2 PF12850.2 EFE39881.1 - 1.3e-11 44.5 0.1 3.1e-11 43.3 0.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EFE39881.1 - 5.6e-10 38.9 0.2 5.4e-09 35.7 0.1 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3635 PF12330.3 EFE39882.1 - 2.4e-07 30.7 0.1 7.2e-07 29.2 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3635) DUF2404 PF10296.4 EFE39883.1 - 0.00015 21.8 0.0 0.0004 20.4 0.0 1.7 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) DUF1682 PF07946.9 EFE39884.1 - 1.4e-105 352.7 1.3 1.6e-105 352.4 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) PBP_sp32 PF07222.7 EFE39884.1 - 0.96 8.5 8.0 1.5 7.9 5.6 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 SYF2 PF08231.7 EFE39887.1 - 1.3e-46 158.4 15.8 1.3e-46 158.4 11.0 2.2 2 0 0 2 2 2 1 SYF2 splicing factor ARD PF03079.9 EFE39887.1 - 0.012 15.5 1.1 0.012 15.5 0.8 3.5 2 1 1 3 3 3 0 ARD/ARD' family Epimerase PF01370.16 EFE39888.1 - 0.0074 15.7 0.0 0.017 14.5 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFE39888.1 - 0.014 15.3 0.3 0.35 10.8 0.0 2.7 2 1 0 2 2 2 0 NADH(P)-binding NAD_binding_4 PF07993.7 EFE39888.1 - 0.045 12.6 3.6 0.57 9.0 0.3 3.4 2 1 0 2 2 2 0 Male sterility protein Pox_RNA_Pol_19 PF05320.7 EFE39888.1 - 0.052 13.2 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit YEATS PF03366.11 EFE39889.1 - 1.7e-35 120.6 0.5 2.6e-35 119.9 0.3 1.3 1 0 0 1 1 1 1 YEATS family Cid2 PF09774.4 EFE39889.1 - 0.023 14.8 0.4 0.033 14.2 0.3 1.3 1 0 0 1 1 1 0 Caffeine-induced death protein 2 Rep_fac_C PF08542.6 EFE39890.1 - 9.9e-22 76.7 0.0 2.4e-21 75.4 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EFE39890.1 - 2.4e-11 43.5 0.0 1.6e-10 40.8 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 EFE39890.1 - 1.1e-09 38.5 0.0 1.9e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE39890.1 - 2e-06 27.9 0.0 4.1e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFE39890.1 - 3.5e-06 26.9 0.0 6.5e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE39890.1 - 4.1e-06 26.9 0.0 0.00012 22.0 0.0 2.4 1 1 2 3 3 3 1 AAA ATPase domain RuvB_N PF05496.7 EFE39890.1 - 8.4e-06 24.9 0.0 2.3e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Rad17 PF03215.10 EFE39890.1 - 1.4e-05 24.0 0.0 0.067 11.8 0.0 2.6 2 1 1 3 3 3 2 Rad17 cell cycle checkpoint protein AAA_10 PF12846.2 EFE39890.1 - 0.00039 19.9 0.0 0.062 12.7 0.0 2.2 1 1 1 2 2 2 1 AAA-like domain DNA_pol3_delta PF06144.8 EFE39890.1 - 0.00056 19.4 0.0 0.00089 18.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Viral_helicase1 PF01443.13 EFE39890.1 - 0.00082 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase DEAD PF00270.24 EFE39890.1 - 0.0023 17.4 0.1 0.22 10.9 0.0 2.6 1 1 0 2 2 2 1 DEAD/DEAH box helicase Mg_chelatase PF01078.16 EFE39890.1 - 0.0028 16.8 0.0 0.027 13.6 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EFE39890.1 - 0.0028 17.3 0.0 0.008 15.9 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain NTPase_1 PF03266.10 EFE39890.1 - 0.0054 16.4 0.1 0.035 13.8 0.0 2.2 2 0 0 2 2 2 1 NTPase AAA_31 PF13614.1 EFE39890.1 - 0.0062 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EFE39890.1 - 0.0078 15.6 0.1 0.45 9.8 0.0 2.8 2 1 0 3 3 3 1 AAA domain AAA_3 PF07726.6 EFE39890.1 - 0.011 15.3 0.1 0.073 12.6 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 EFE39890.1 - 0.014 14.9 0.0 0.028 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.5 EFE39890.1 - 0.014 14.6 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF2075 PF09848.4 EFE39890.1 - 0.015 14.3 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ArgK PF03308.11 EFE39890.1 - 0.016 13.9 0.0 0.027 13.2 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_18 PF13238.1 EFE39890.1 - 0.022 15.0 0.0 0.041 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFE39890.1 - 0.028 13.9 0.0 0.063 12.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family His_Phos_2 PF00328.17 EFE39891.1 - 1.6e-06 27.6 0.0 3.6e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF1338 PF07063.8 EFE39892.1 - 3e-80 269.5 0.0 3.5e-80 269.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) DUF410 PF04190.8 EFE39894.1 - 1.1e-42 146.4 0.0 1.3e-42 146.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) RAI1 PF08652.6 EFE39895.1 - 6.6e-28 96.2 0.0 1.2e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease IPPT PF01715.12 EFE39896.1 - 6.5e-51 172.7 6.7 9.8e-28 96.8 3.7 3.1 2 1 0 2 2 2 2 IPP transferase AAA_33 PF13671.1 EFE39896.1 - 3.6e-05 23.6 0.6 0.17 11.7 0.0 3.1 3 0 0 3 3 3 2 AAA domain IPT PF01745.11 EFE39896.1 - 7.3e-05 22.0 0.6 0.00017 20.8 0.0 1.8 2 1 0 2 2 2 1 Isopentenyl transferase zf-met PF12874.2 EFE39896.1 - 0.00035 20.6 0.0 0.00063 19.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type AAA_18 PF13238.1 EFE39896.1 - 0.00035 20.8 2.7 0.6 10.4 0.0 3.4 2 1 1 3 3 3 2 AAA domain zf-C2H2_jaz PF12171.3 EFE39896.1 - 0.00054 20.0 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EFE39896.1 - 0.0018 18.3 1.0 0.0059 16.7 0.0 2.1 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AAA_17 PF13207.1 EFE39896.1 - 0.0047 17.7 0.0 0.0047 17.7 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_25 PF13481.1 EFE39896.1 - 0.0074 15.7 0.3 0.074 12.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain PhoH PF02562.11 EFE39896.1 - 0.076 12.2 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.1 EFE39896.1 - 0.084 12.6 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain VASP_tetra PF08776.6 EFE39896.1 - 0.092 12.0 5.1 0.063 12.5 0.4 2.6 2 0 0 2 2 2 0 VASP tetramerisation domain DUF87 PF01935.12 EFE39896.1 - 0.27 10.9 4.8 1.1 9.0 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF87 AAA_23 PF13476.1 EFE39896.1 - 4.1 7.6 10.8 22 5.2 3.0 2.9 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.22 EFE39897.1 - 3.2e-16 59.8 0.1 1.6e-15 57.5 0.1 2.0 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EFE39897.1 - 1.1e-10 41.9 0.4 0.00015 21.8 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 EFE39897.1 - 1.2e-05 24.6 0.0 0.078 12.0 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EFE39897.1 - 1.9e-05 24.1 0.1 4.3e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.14 EFE39897.1 - 4e-05 22.9 0.0 0.12 11.5 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFE39897.1 - 0.0009 19.6 0.1 0.0014 19.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 EFE39897.1 - 0.0016 17.9 0.1 0.0062 16.0 0.0 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 EFE39897.1 - 0.0034 16.8 0.1 0.0041 16.6 0.1 1.3 1 1 0 1 1 1 1 AAA-like domain DUF258 PF03193.11 EFE39897.1 - 0.0068 15.6 0.0 0.0093 15.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFE39897.1 - 0.0098 16.7 0.5 0.027 15.2 0.3 1.8 1 1 0 1 1 1 1 AAA domain DUF3584 PF12128.3 EFE39897.1 - 0.017 12.4 0.1 0.023 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Dynamin_N PF00350.18 EFE39897.1 - 0.019 14.7 0.3 0.032 14.0 0.2 1.3 1 0 0 1 1 1 0 Dynamin family AAA_25 PF13481.1 EFE39897.1 - 0.031 13.6 0.0 0.067 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFE39897.1 - 0.034 14.1 0.8 0.056 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.12 EFE39897.1 - 0.038 13.8 0.2 0.4 10.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_14 PF13173.1 EFE39897.1 - 0.063 13.1 0.1 1 9.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.10 EFE39897.1 - 0.068 11.8 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein PduV-EutP PF10662.4 EFE39897.1 - 0.075 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 EFE39897.1 - 0.1 12.5 0.3 0.21 11.5 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFE39897.1 - 0.11 12.6 0.2 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 EFE39897.1 - 0.13 12.1 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase WD40 PF00400.27 EFE39898.1 - 8.1e-60 196.7 33.9 2.6e-09 36.5 0.0 12.8 14 0 0 14 14 14 9 WD domain, G-beta repeat MucBP PF06458.7 EFE39898.1 - 0.12 13.0 0.0 1.3 9.6 0.0 2.4 2 0 0 2 2 2 0 MucBP domain Urm1 PF09138.6 EFE39899.1 - 2e-08 34.2 0.0 3e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) 6PF2K PF01591.13 EFE39900.1 - 5.4e-24 84.5 1.4 1.3e-11 43.9 0.2 2.8 1 1 1 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EFE39900.1 - 5.1e-22 78.6 0.5 7.5e-22 78.1 0.4 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Porin_3 PF01459.17 EFE39901.1 - 8.5e-79 264.6 0.0 9.8e-79 264.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Zds_C PF08632.5 EFE39901.1 - 0.012 14.9 0.0 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term 2OG-FeII_Oxy_2 PF13532.1 EFE39903.1 - 1.5e-21 77.1 0.0 5.2e-21 75.3 0.0 2.0 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Chromo PF00385.19 EFE39903.1 - 0.002 17.7 0.4 0.0062 16.1 0.1 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain RE_R_Pab1 PF09522.5 EFE39903.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 R.Pab1 restriction endonuclease Ribosomal_L40e PF01020.12 EFE39903.1 - 0.56 9.8 2.5 1.2 8.7 1.1 2.0 2 0 0 2 2 2 0 Ribosomal L40e family AMP-binding PF00501.23 EFE39904.1 - 1.1e-73 248.0 0.1 5.6e-72 242.4 0.1 2.0 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE39904.1 - 2e-13 51.1 0.2 7.3e-13 49.2 0.1 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain WD40 PF00400.27 EFE39905.1 - 2.4e-32 109.6 6.1 2.5e-06 27.1 0.0 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EFE39905.1 - 5.3e-05 22.6 0.0 0.83 9.2 0.0 3.4 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.1 EFE39905.1 - 0.11 11.4 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus NDUF_B12 PF08122.7 EFE39906.1 - 5.6e-18 64.4 0.9 8.1e-18 63.8 0.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family PsbN PF02468.10 EFE39906.1 - 0.17 11.5 1.4 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) CAF1 PF04857.15 EFE39907.1 - 0.0019 17.5 0.0 0.0082 15.5 0.0 1.8 2 0 0 2 2 2 1 CAF1 family ribonuclease DUF2828 PF11443.3 EFE39907.1 - 0.027 12.6 0.0 0.029 12.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) LacAB_rpiB PF02502.13 EFE39907.1 - 0.095 12.3 0.1 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribose/Galactose Isomerase APC_CDC26 PF10471.4 EFE39907.1 - 3.1 8.5 12.7 6.3 7.6 0.3 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 CAF1 PF04857.15 EFE39908.1 - 5.3e-48 163.6 0.0 6.9e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease Cu_amine_oxid PF01179.15 EFE39909.1 - 9.3e-137 456.1 0.1 1.2e-136 455.7 0.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.11 EFE39909.1 - 4.7e-17 61.8 0.1 9.4e-17 60.9 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.11 EFE39909.1 - 7.9e-15 54.7 0.0 1.3e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Asp PF00026.18 EFE39910.1 - 3.9e-56 190.5 0.1 4.7e-56 190.3 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 EFE39910.1 - 0.00022 20.7 0.0 0.0056 16.2 0.0 2.3 1 1 1 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 EFE39910.1 - 0.00081 19.8 0.2 1.8 9.1 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.1 EFE39910.1 - 0.062 13.1 0.1 0.87 9.4 0.0 2.5 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease TPR_11 PF13414.1 EFE39911.1 - 5e-14 51.6 0.8 1.7e-09 37.1 0.8 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 EFE39911.1 - 4.2e-07 29.3 5.0 0.011 15.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFE39911.1 - 6.6e-07 28.6 1.2 0.41 10.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFE39911.1 - 1.9e-05 24.5 3.8 0.016 15.1 0.3 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat Apc3 PF12895.2 EFE39911.1 - 0.00053 20.0 0.0 0.0011 19.0 0.0 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EFE39911.1 - 0.0017 17.9 0.8 0.5 10.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 EFE39911.1 - 0.0019 17.9 0.3 0.0069 16.2 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE39911.1 - 0.0062 17.1 1.7 5.8 7.7 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat RRM_5 PF13893.1 EFE39911.1 - 0.012 15.3 0.0 0.043 13.6 0.0 1.9 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_7 PF13176.1 EFE39911.1 - 0.014 15.1 4.0 9.8 6.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE39911.1 - 0.061 13.9 4.2 8 7.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE39911.1 - 0.072 13.4 0.6 0.44 10.9 0.2 2.4 2 1 0 2 2 1 0 Tetratricopeptide repeat Neuralized PF07177.7 EFE39911.1 - 0.14 12.0 0.0 3 7.8 0.0 2.3 2 0 0 2 2 2 0 Neuralized TPR_10 PF13374.1 EFE39911.1 - 0.45 10.5 2.4 17 5.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFE39911.1 - 2.3 8.8 5.9 4.9 7.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat GRAM PF02893.15 EFE39912.1 - 4.1e-16 58.2 0.0 1e-15 56.9 0.0 1.7 2 0 0 2 2 2 1 GRAM domain PAP_assoc PF03828.14 EFE39913.1 - 7e-12 45.1 0.0 1.3e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 EFE39913.1 - 1.1e-08 35.2 0.0 2.7e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Aldo_ket_red PF00248.16 EFE39914.1 - 1.1e-66 224.5 0.0 1.4e-66 224.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_S16 PF00886.14 EFE39914.1 - 0.062 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S16 FA_hydroxylase PF04116.8 EFE39915.1 - 5.3e-16 59.0 23.2 5.3e-16 59.0 16.1 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily COX14 PF14880.1 EFE39916.1 - 1.2e-10 40.8 0.6 5.5e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 Cytochrome oxidase c assembly PVL_ORF50 PF07768.6 EFE39916.1 - 0.068 13.1 0.2 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 PVL ORF-50-like family CENP-Q PF13094.1 EFE39916.1 - 0.23 11.4 3.3 0.75 9.8 1.4 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Pol_alpha_B_N PF08418.5 EFE39916.1 - 3.2 7.2 10.5 0.71 9.3 1.3 2.1 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Methyltransf_23 PF13489.1 EFE39917.1 - 0.00063 19.4 0.0 0.0011 18.7 0.0 1.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE39917.1 - 0.11 13.0 0.0 0.47 11.0 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain PrmA PF06325.8 EFE39917.1 - 0.12 11.4 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) HP_OMP_2 PF02521.9 EFE39918.1 - 0.032 12.8 0.0 0.042 12.4 0.0 1.1 1 0 0 1 1 1 0 Putative outer membrane protein HAD_2 PF13419.1 EFE39919.1 - 3.6e-22 79.4 0.0 4.4e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFE39919.1 - 6.6e-12 46.3 0.1 9.3e-11 42.5 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFE39919.1 - 2.5e-10 40.8 0.0 3.4e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE39919.1 - 1.8e-08 33.9 0.1 5.4e-08 32.4 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 EFE39919.1 - 4.2e-07 29.8 0.0 0.00039 20.2 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.2 EFE39919.1 - 0.008 15.8 0.2 0.84 9.2 0.0 2.8 3 0 0 3 3 3 1 Acid Phosphatase Hydrolase_3 PF08282.7 EFE39919.1 - 0.031 13.8 0.0 0.46 10.0 0.0 2.5 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Peptidase_M35 PF02102.10 EFE39920.1 - 1.9e-98 329.4 0.9 2.2e-98 329.2 0.6 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.1 EFE39920.1 - 0.00016 22.2 0.6 0.00038 20.9 0.4 1.7 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase Actin PF00022.14 EFE39921.1 - 3.7e-137 456.9 0.0 4.2e-137 456.7 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EFE39921.1 - 0.046 12.3 0.0 9.2 4.7 0.0 2.9 3 0 0 3 3 3 0 MreB/Mbl protein ATG22 PF11700.3 EFE39922.1 - 6.1e-196 651.5 21.5 2.9e-189 629.4 8.8 2.0 1 1 1 2 2 2 2 Vacuole effluxer Atg22 like MFS_1 PF07690.11 EFE39922.1 - 0.00019 20.2 57.6 0.00063 18.5 17.6 3.4 2 2 1 3 3 3 2 Major Facilitator Superfamily Hum_adeno_E3A PF05393.6 EFE39922.1 - 0.15 11.7 0.1 0.15 11.7 0.1 2.2 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein Mpp10 PF04006.7 EFE39923.1 - 4.1e-91 306.1 79.0 3.6e-90 303.0 54.7 2.2 1 1 0 1 1 1 1 Mpp10 protein Methyltransf_16 PF10294.4 EFE39924.1 - 3.5e-36 124.2 0.0 4.8e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 EFE39924.1 - 0.034 13.2 0.2 0.059 12.4 0.1 1.4 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EFE39924.1 - 0.052 12.9 0.1 0.091 12.1 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.2 EFE39924.1 - 0.14 12.7 0.1 0.21 12.1 0.1 1.4 1 1 0 1 1 1 0 Methyltransferase domain CDC27 PF09507.5 EFE39926.1 - 0.0057 15.9 18.9 0.0061 15.8 13.1 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Hox9_act PF04617.8 EFE39926.1 - 0.027 14.6 6.3 0.045 13.9 4.3 1.3 1 0 0 1 1 1 0 Hox9 activation region Paf1 PF03985.8 EFE39926.1 - 0.037 12.7 7.7 0.045 12.4 5.3 1.1 1 0 0 1 1 1 0 Paf1 Pox_Ag35 PF03286.9 EFE39926.1 - 0.12 11.8 13.4 0.17 11.3 9.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Spore_coat_CotO PF14153.1 EFE39926.1 - 0.37 10.2 13.0 0.45 9.9 9.0 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Mitofilin PF09731.4 EFE39926.1 - 0.5 8.9 15.6 0.52 8.8 10.8 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Daxx PF03344.10 EFE39926.1 - 2 6.7 14.6 2.4 6.5 10.2 1.1 1 0 0 1 1 1 0 Daxx Family DDRGK PF09756.4 EFE39926.1 - 2.1 7.7 16.3 2.9 7.2 11.3 1.2 1 0 0 1 1 1 0 DDRGK domain DUF1510 PF07423.6 EFE39926.1 - 2.4 7.4 17.1 3.4 6.9 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NPR3 PF03666.8 EFE39926.1 - 2.6 6.5 5.6 3.3 6.1 3.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM176 PF14851.1 EFE39926.1 - 2.7 7.6 5.4 3.9 7.1 3.7 1.3 1 0 0 1 1 1 0 FAM176 family Vfa1 PF08432.5 EFE39926.1 - 2.9 7.8 15.3 4.1 7.3 10.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.9 EFE39926.1 - 3.4 5.5 7.2 4.2 5.2 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Vesiculo_matrix PF06326.7 EFE39927.1 - 0.044 13.2 0.1 0.076 12.4 0.1 1.3 1 0 0 1 1 1 0 Vesiculovirus matrix protein V-SNARE_C PF12352.3 EFE39927.1 - 0.079 13.0 0.6 0.079 13.0 0.4 2.2 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus DDHD PF02862.12 EFE39927.1 - 9.1 6.0 7.5 12 5.6 4.6 1.7 1 1 0 1 1 1 0 DDHD domain Sec1 PF00995.18 EFE39928.1 - 1.4e-123 413.5 0.0 2.3e-123 412.7 0.0 1.3 1 1 0 1 1 1 1 Sec1 family SF3b1 PF08920.5 EFE39929.1 - 1.1e-41 142.2 9.9 4.5e-41 140.2 0.4 2.4 1 1 1 2 2 2 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.1 EFE39929.1 - 4.5e-14 52.5 4.7 0.011 16.0 0.0 7.2 5 3 2 7 7 7 4 HEAT repeats HEAT PF02985.17 EFE39929.1 - 2.4e-10 39.6 9.9 1 9.6 0.0 9.3 10 0 0 10 10 10 2 HEAT repeat HEAT_EZ PF13513.1 EFE39929.1 - 1.2e-08 35.1 5.7 0.53 10.8 0.0 7.1 5 2 2 7 7 7 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFE39929.1 - 1.3e-05 25.4 0.2 1.1 9.6 0.0 5.5 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region NUC173 PF08161.7 EFE39929.1 - 0.0056 16.0 0.4 4.3 6.6 0.0 3.8 4 0 0 4 4 4 1 NUC173 domain CLASP_N PF12348.3 EFE39929.1 - 0.0091 15.3 0.2 1 8.6 0.0 3.3 3 0 0 3 3 3 1 CLASP N terminal CRM1_C PF08767.6 EFE39929.1 - 0.094 11.6 0.8 0.39 9.5 0.0 2.3 3 0 0 3 3 3 0 CRM1 C terminal DUF3455 PF11937.3 EFE39930.1 - 1.4e-17 64.1 0.0 1.8e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Methyltransf_11 PF08241.7 EFE39931.1 - 0.0056 17.1 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 EFE39931.1 - 0.075 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family p450 PF00067.17 EFE39933.1 - 0.042 12.3 0.1 0.059 11.8 0.0 1.2 1 0 0 1 1 1 0 Cytochrome P450 NfeD PF01957.13 EFE39936.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding TPR_1 PF00515.23 EFE39937.1 - 8.6e-41 135.9 6.9 9.6e-07 28.1 0.0 8.5 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.1 EFE39937.1 - 5.5e-37 125.2 24.8 2.2e-12 46.4 1.3 7.9 6 2 2 8 8 8 7 TPR repeat TPR_2 PF07719.12 EFE39937.1 - 9e-35 115.7 13.0 0.00052 19.7 0.0 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat Apc3 PF12895.2 EFE39937.1 - 6.1e-28 96.7 16.0 5.8e-21 74.4 0.2 4.9 3 1 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 EFE39937.1 - 3.4e-25 88.1 17.7 3.7e-10 40.1 0.5 8.3 6 2 2 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 EFE39937.1 - 1.6e-24 83.7 2.2 0.00016 21.2 0.4 8.9 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.1 EFE39937.1 - 6.4e-23 80.8 13.5 1.4e-07 31.6 0.3 7.1 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE39937.1 - 5.2e-20 70.1 9.3 0.0049 17.3 0.1 9.5 6 1 3 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.1 EFE39937.1 - 1.4e-18 66.5 19.9 3.6e-05 23.6 0.0 7.5 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.1 EFE39937.1 - 5.4e-14 51.1 14.5 0.00097 19.1 0.0 9.7 12 0 0 12 12 9 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE39937.1 - 1.1e-10 40.4 6.1 0.046 13.5 0.0 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFE39937.1 - 1.3e-08 34.6 10.3 0.58 10.7 0.1 7.6 10 0 0 10 10 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFE39937.1 - 0.0011 18.7 3.7 0.24 11.2 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat ChAPs PF09295.5 EFE39937.1 - 0.0084 14.9 0.1 0.51 9.0 0.0 2.4 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) FAT PF02259.18 EFE39937.1 - 0.013 14.4 2.0 0.061 12.2 0.1 2.7 2 1 0 2 2 2 0 FAT domain TPR_21 PF09976.4 EFE39937.1 - 0.23 11.3 5.3 6.5 6.6 0.4 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Acyltransferase PF01553.16 EFE39938.1 - 8.8e-31 106.0 0.0 1.4e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase ACPS PF01648.15 EFE39939.1 - 1.4e-11 44.2 0.0 8.8e-11 41.6 0.0 2.0 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily SNO PF01174.14 EFE39940.1 - 2.5e-51 174.0 0.0 1.4e-40 138.9 0.0 2.1 1 1 1 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.9 EFE39940.1 - 2.5e-09 36.9 0.0 2.4e-07 30.4 0.0 2.5 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 EFE39940.1 - 0.00033 20.1 0.0 0.0036 16.7 0.0 2.2 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DUF4066 PF13278.1 EFE39940.1 - 0.0052 16.0 0.0 0.0078 15.4 0.0 1.3 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 EFE39940.1 - 0.0059 16.0 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.12 EFE39940.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S51 WD40 PF00400.27 EFE39941.1 - 0.0068 16.2 0.2 0.078 12.8 0.1 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat Rotamase PF00639.16 EFE39943.1 - 3.5e-19 69.3 0.1 6.3e-19 68.5 0.1 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 EFE39943.1 - 2.7e-13 50.2 0.0 3.7e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 EFE39943.1 - 1.7e-09 37.3 0.2 3.7e-09 36.2 0.2 1.6 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.1 EFE39943.1 - 2.1e-06 28.3 0.0 3e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Calcipressin PF04847.7 EFE39945.1 - 2.3e-32 112.0 0.3 9.1e-32 110.1 0.2 1.9 1 1 0 1 1 1 1 Calcipressin Pex14_N PF04695.8 EFE39946.1 - 7.6e-31 106.9 1.8 7.6e-31 106.9 1.2 2.4 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region S-antigen PF05756.6 EFE39946.1 - 0.81 9.6 0.0 0.81 9.6 0.0 2.4 2 1 1 3 3 3 0 S-antigen protein Rad52_Rad22 PF04098.10 EFE39947.1 - 0.032 13.9 0.0 0.046 13.4 0.0 1.4 1 1 0 1 1 1 0 Rad52/22 family double-strand break repair protein PAPA-1 PF04795.7 EFE39948.1 - 5.4e-25 87.9 4.7 5.4e-25 87.9 3.2 2.8 3 1 0 3 3 3 1 PAPA-1-like conserved region NOA36 PF06524.7 EFE39948.1 - 2.1 7.5 20.9 2.2 7.4 3.8 2.4 2 0 0 2 2 2 0 NOA36 protein Mus7 PF09462.5 EFE39949.1 - 6.1e-159 530.7 0.0 8.8e-159 530.2 0.0 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family DUF4050 PF13259.1 EFE39950.1 - 8.7e-39 132.2 0.0 2e-38 131.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4050) TPR_12 PF13424.1 EFE39951.1 - 8.5e-05 22.4 5.7 0.35 10.8 0.5 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFE39951.1 - 0.00071 19.8 8.8 0.16 12.2 2.9 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE39951.1 - 0.00077 20.0 5.6 0.011 16.3 0.7 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE39951.1 - 0.016 15.0 3.6 20 5.4 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.4 EFE39951.1 - 0.023 14.6 1.5 0.033 14.1 0.2 1.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFE39951.1 - 0.14 11.7 0.8 29 4.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 EFE39952.1 - 3.5e-16 59.1 0.0 5.5e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39952.1 - 6.5e-10 38.5 0.0 3.4e-09 36.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EFE39952.1 - 0.01 15.5 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 EFE39952.1 - 0.016 14.5 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.6 EFE39952.1 - 0.02 13.7 0.1 0.038 12.7 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase AAA PF00004.24 EFE39953.1 - 4.6e-39 133.6 0.0 6.4e-38 129.9 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE39953.1 - 4.8e-05 23.5 0.1 0.0015 18.6 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE39953.1 - 0.0001 22.3 0.1 0.0053 16.7 0.0 2.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 EFE39953.1 - 0.00012 21.2 0.0 0.00026 20.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 EFE39953.1 - 0.00029 19.6 0.0 0.00063 18.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 EFE39953.1 - 0.0005 19.8 0.0 0.0021 17.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EFE39953.1 - 0.0006 20.6 0.1 0.0023 18.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFE39953.1 - 0.00063 19.6 0.0 0.0038 17.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EFE39953.1 - 0.003 16.7 0.1 0.007 15.5 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EFE39953.1 - 0.0032 17.1 0.2 0.0085 15.8 0.2 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 EFE39953.1 - 0.0036 17.1 0.0 0.0097 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EFE39953.1 - 0.0051 16.2 0.0 0.0098 15.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Ribosomal_60s PF00428.14 EFE39953.1 - 0.011 16.0 0.8 0.067 13.6 0.1 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein AAA_28 PF13521.1 EFE39953.1 - 0.015 15.2 0.0 0.015 15.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.17 EFE39953.1 - 0.017 15.3 0.0 0.047 13.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 EFE39953.1 - 0.027 14.0 0.1 0.074 12.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EFE39953.1 - 0.036 13.4 0.2 7.3 5.9 0.0 2.4 1 1 0 2 2 2 0 AAA-like domain SHQ1 PF04925.10 EFE39953.1 - 0.039 13.4 0.1 0.27 10.6 0.0 2.1 2 0 0 2 2 2 0 SHQ1 protein AAA_25 PF13481.1 EFE39953.1 - 0.054 12.8 0.1 0.24 10.7 0.1 2.0 1 1 1 2 2 2 0 AAA domain AAA_2 PF07724.9 EFE39953.1 - 0.069 13.0 0.0 0.6 9.9 0.0 2.6 2 1 0 2 2 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.7 EFE39953.1 - 0.069 12.7 0.1 0.27 10.8 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Pex14_N PF04695.8 EFE39953.1 - 0.11 12.6 2.5 0.11 12.5 0.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IPT PF01745.11 EFE39953.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Transpeptidase PF00905.17 EFE39953.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain Sigma54_activat PF00158.21 EFE39953.1 - 0.14 11.6 0.2 1.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.1 EFE39953.1 - 0.18 12.0 2.5 0.24 11.6 0.0 2.4 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.7 EFE39953.1 - 1.3 8.0 5.8 0.33 10.0 0.0 2.7 4 0 0 4 4 3 0 Zeta toxin NGP1NT PF08153.7 EFE39955.1 - 5.8e-49 165.3 0.1 8.5e-49 164.8 0.1 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain SusD-like_3 PF14322.1 EFE39955.1 - 0.003 17.6 0.0 0.0067 16.5 0.0 1.5 1 0 0 1 1 1 1 Starch-binding associating with outer membrane MMR_HSR1 PF01926.18 EFE39956.1 - 4.3e-15 55.6 0.0 7e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE39956.1 - 2.8e-05 23.4 0.0 3.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 EFE39956.1 - 0.002 17.3 0.0 0.0039 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EFE39956.1 - 0.0021 17.9 0.6 0.062 13.1 0.1 2.9 2 1 0 2 2 2 1 Dynamin family Arf PF00025.16 EFE39956.1 - 0.072 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family IIGP PF05049.8 EFE39956.1 - 0.17 10.6 0.1 0.25 10.0 0.1 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) PPV_E1_C PF00519.12 EFE39956.1 - 0.18 10.3 0.1 0.48 8.9 0.0 1.6 1 1 0 2 2 2 0 Papillomavirus helicase Grp1_Fun34_YaaH PF01184.14 EFE39957.1 - 2.9e-48 163.9 9.0 4.1e-48 163.4 6.3 1.2 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family YrhC PF14143.1 EFE39957.1 - 2.6 8.0 7.7 1.5 8.7 3.4 2.0 1 1 1 2 2 2 0 YrhC-like protein DUF2207 PF09972.4 EFE39957.1 - 4 5.9 5.6 5 5.5 3.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF202 PF02656.10 EFE39957.1 - 8.7 6.6 10.9 11 6.2 0.1 3.6 1 1 0 2 2 2 0 Domain of unknown function (DUF202) p450 PF00067.17 EFE39958.1 - 5.8e-65 219.6 0.0 6.4e-65 219.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TFIIE_alpha PF02002.12 EFE39958.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit Pkinase PF00069.20 EFE39959.1 - 6.4e-40 136.9 0.0 2.5e-39 135.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE39959.1 - 6.2e-29 100.8 0.0 8.7e-29 100.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE39959.1 - 0.015 14.2 0.0 0.034 13.1 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Prefoldin_3 PF13758.1 EFE39960.1 - 3.2e-34 116.6 0.1 9.9e-34 115.0 0.1 1.9 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.2 EFE39960.1 - 6.9e-23 81.4 9.5 3.1e-21 76.0 0.3 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF3835) Lzipper-MIP1 PF14389.1 EFE39960.1 - 0.0024 17.9 1.6 0.14 12.2 0.0 2.9 2 0 0 2 2 2 1 Leucine-zipper of ternary complex factor MIP1 Prefoldin PF02996.12 EFE39960.1 - 0.0072 15.9 0.1 0.023 14.3 0.1 1.9 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.15 EFE39960.1 - 0.031 14.0 3.7 0.9 9.3 0.0 3.3 3 0 0 3 3 3 0 Prefoldin subunit PepSY_2 PF13670.1 EFE39960.1 - 0.049 13.5 0.3 0.56 10.1 0.1 2.6 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain MerR-DNA-bind PF09278.6 EFE39960.1 - 0.07 13.5 0.7 14 6.1 0.0 3.1 3 0 0 3 3 3 0 MerR, DNA binding Zip PF02535.17 EFE39961.1 - 1.2e-37 129.6 20.4 1.2e-37 129.6 14.2 2.0 2 0 0 2 2 2 1 ZIP Zinc transporter Amino_oxidase PF01593.19 EFE39962.1 - 1.7e-06 27.4 0.6 2.8e-05 23.3 0.4 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase RFC1 PF08519.7 EFE39963.1 - 1.6e-56 190.3 0.3 9.3e-56 187.8 0.0 2.2 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.21 EFE39963.1 - 1.1e-12 47.9 0.0 3.6e-12 46.2 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.24 EFE39963.1 - 5.2e-09 36.4 1.2 7.7e-09 35.8 0.1 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE39963.1 - 2.9e-06 27.4 0.0 8.8e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE39963.1 - 3.2e-05 24.7 0.3 0.00016 22.5 0.0 2.5 2 0 0 2 2 1 1 AAA domain Rad17 PF03215.10 EFE39963.1 - 0.00079 18.2 0.0 0.0023 16.7 0.0 1.7 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 EFE39963.1 - 0.0013 18.4 0.1 0.0036 17.0 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 EFE39963.1 - 0.0022 17.1 0.0 0.0041 16.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EFE39963.1 - 0.0055 16.6 0.1 0.032 14.1 0.0 2.3 2 1 1 3 3 2 1 AAA ATPase domain AAA_14 PF13173.1 EFE39963.1 - 0.0072 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFE39963.1 - 0.014 15.2 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain PTCB-BRCT PF12738.2 EFE39963.1 - 0.038 13.8 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 twin BRCT domain Sigma54_activat PF00158.21 EFE39963.1 - 0.05 13.0 0.0 0.096 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.1 EFE39963.1 - 0.053 13.8 0.1 0.053 13.8 0.1 2.7 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.9 EFE39963.1 - 0.057 13.1 0.0 0.31 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 EFE39963.1 - 0.067 12.8 0.0 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 NACHT domain DNA_pol3_delta2 PF13177.1 EFE39964.1 - 6.5e-11 42.1 0.1 1.2e-10 41.2 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 EFE39964.1 - 5.4e-07 29.8 0.1 1.1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE39964.1 - 8.9e-06 25.8 0.3 5.4e-05 23.3 0.1 2.3 1 1 1 2 2 2 1 AAA domain Rep_fac_C PF08542.6 EFE39964.1 - 2e-05 24.4 0.1 6.9e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_16 PF13191.1 EFE39964.1 - 0.0069 16.3 0.8 0.2 11.6 0.6 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_10 PF12846.2 EFE39964.1 - 0.0099 15.3 0.1 0.68 9.3 0.0 2.2 1 1 0 2 2 2 1 AAA-like domain ABC_tran PF00005.22 EFE39964.1 - 0.012 15.8 0.2 0.027 14.7 0.1 1.8 1 1 0 1 1 1 0 ABC transporter SNF2_N PF00176.18 EFE39964.1 - 0.017 13.9 0.1 0.025 13.3 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_33 PF13671.1 EFE39964.1 - 0.02 14.7 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain TK PF00265.13 EFE39964.1 - 0.051 13.1 0.6 0.27 10.7 0.4 2.0 1 1 0 1 1 1 0 Thymidine kinase Methyltransf_31 PF13847.1 EFE39964.1 - 0.07 12.7 0.1 0.57 9.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Sigma54_activ_2 PF14532.1 EFE39964.1 - 0.087 12.8 0.2 0.33 10.9 0.2 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.1 EFE39964.1 - 0.37 10.3 1.9 1.9 8.0 1.3 2.0 1 1 0 1 1 1 0 AAA domain MBF1 PF08523.5 EFE39966.1 - 2.4e-27 94.7 0.4 4.6e-27 93.8 0.3 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 EFE39966.1 - 6.8e-12 45.0 0.1 1.6e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.1 EFE39966.1 - 6.2e-08 32.7 0.2 1.5e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.2 EFE39966.1 - 0.00017 21.5 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Iso_dh PF00180.15 EFE39967.1 - 2.4e-49 168.1 0.0 1.3e-48 165.7 0.0 1.8 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase BRF1 PF07741.8 EFE39968.1 - 1.9 8.7 13.8 1.9 8.7 9.6 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain RNA_pol_Rpc4 PF05132.9 EFE39968.1 - 3.3 7.6 10.7 3.4 7.6 7.4 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF2413 PF10310.4 EFE39968.1 - 3.8 6.2 8.4 3.9 6.1 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) DUF1510 PF07423.6 EFE39968.1 - 4.4 6.6 12.0 4.5 6.5 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SR-25 PF10500.4 EFE39968.1 - 6.1 6.2 20.2 6.3 6.2 14.0 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein YqfQ PF14181.1 EFE39968.1 - 6.3 6.8 11.1 6.2 6.8 7.7 1.0 1 0 0 1 1 1 0 YqfQ-like protein DNA_pol_A_exo1 PF01612.15 EFE39969.1 - 2.3e-41 141.2 0.5 3.7e-41 140.5 0.3 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.7 EFE39969.1 - 1.2e-20 73.5 5.8 6.7e-10 39.1 0.7 3.2 2 1 1 3 3 3 2 PMC2NT (NUC016) domain HRDC PF00570.18 EFE39969.1 - 7.2e-12 44.8 0.5 1.9e-11 43.4 0.0 2.0 2 0 0 2 2 2 1 HRDC domain Gpi1 PF05024.10 EFE39970.1 - 5.8e-19 68.5 0.9 1e-18 67.7 0.6 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) MutS_V PF00488.16 EFE39971.1 - 1.2e-95 319.4 0.0 1.9e-95 318.7 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFE39971.1 - 4.1e-39 134.4 0.4 8.6e-39 133.4 0.3 1.6 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.12 EFE39971.1 - 5.5e-23 81.5 0.1 2.3e-22 79.5 0.0 2.1 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 EFE39971.1 - 8.1e-19 67.6 0.4 2.9e-18 65.8 0.3 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.15 EFE39971.1 - 2.4e-15 56.5 0.0 1.8e-14 53.7 0.0 2.3 2 0 0 2 2 2 1 MutS domain I zf-C2H2_4 PF13894.1 EFE39974.1 - 3.5e-06 26.9 13.3 0.00057 20.0 1.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFE39974.1 - 7.1e-06 26.0 4.0 7.1e-06 26.0 2.8 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.21 EFE39974.1 - 7.6e-05 22.8 11.6 0.03 14.6 1.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Kinesin PF00225.18 EFE39974.1 - 0.031 12.9 0.0 0.031 12.9 0.0 1.6 2 0 0 2 2 2 0 Kinesin motor domain DUF2413 PF10310.4 EFE39975.1 - 0.033 13.0 6.9 0.036 12.8 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) MIP-T3 PF10243.4 EFE39975.1 - 0.2 10.1 18.0 0.21 10.0 12.5 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RNase_H2-Ydr279 PF09468.5 EFE39975.1 - 0.93 8.6 10.3 1.2 8.2 7.2 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) eIF-3_zeta PF05091.7 EFE39975.1 - 1.1 7.7 8.1 1.3 7.5 5.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FLO_LFY PF01698.11 EFE39975.1 - 1.2 7.8 10.2 1.5 7.5 7.1 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein FCP1_C PF09309.5 EFE39975.1 - 1.2 8.3 13.2 1.6 7.9 9.1 1.1 1 0 0 1 1 1 0 FCP1, C-terminal CDC45 PF02724.9 EFE39975.1 - 1.9 6.4 12.5 2.1 6.2 8.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Dsh_C PF12316.3 EFE39975.1 - 2.3 8.3 9.9 3.1 7.8 6.9 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Herpes_DNAp_acc PF04929.7 EFE39975.1 - 4.2 6.2 8.3 5.3 5.9 5.7 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DDHD PF02862.12 EFE39975.1 - 7 6.3 7.5 8.6 6.0 5.2 1.2 1 0 0 1 1 1 0 DDHD domain YqfQ PF14181.1 EFE39975.1 - 7.3 6.6 9.5 12 5.9 6.6 1.4 1 0 0 1 1 1 0 YqfQ-like protein COG5 PF10392.4 EFE39976.1 - 1.9e-37 128.1 1.9 3.3e-37 127.3 0.0 2.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 SYS1 PF09801.4 EFE39977.1 - 5.9e-53 178.7 7.8 6.9e-53 178.5 5.4 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF485 PF04341.7 EFE39977.1 - 0.017 14.7 2.6 0.017 14.7 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF485 COX6B PF02297.12 EFE39978.1 - 1.6e-23 82.5 3.9 2e-23 82.1 2.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Prolamin_like PF05617.6 EFE39978.1 - 0.092 12.8 0.3 0.13 12.3 0.2 1.4 1 1 0 1 1 1 0 Prolamin-like CHCH PF06747.8 EFE39978.1 - 0.17 11.8 2.8 1.5 8.8 0.5 2.5 2 1 0 2 2 2 0 CHCH domain Pyr_redox_2 PF07992.9 EFE39979.1 - 6.6e-29 101.2 0.0 1.3e-28 100.2 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE39979.1 - 5.8e-18 65.0 0.4 3.6e-15 56.1 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE39979.1 - 7e-14 52.3 0.0 3e-06 27.4 0.0 3.3 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE39979.1 - 5e-06 25.6 0.0 0.037 12.9 0.0 2.6 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Reductase_C PF14759.1 EFE39979.1 - 5.6e-06 26.5 0.0 1.5e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 Reductase C-terminal NAD_binding_9 PF13454.1 EFE39979.1 - 3.9e-05 23.4 0.3 0.2 11.4 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_7 PF13241.1 EFE39979.1 - 0.00088 19.4 0.3 0.33 11.2 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding HI0933_like PF03486.9 EFE39979.1 - 0.0074 14.8 0.4 1.2 7.4 0.0 2.7 3 0 0 3 3 3 2 HI0933-like protein DUF1188 PF06690.6 EFE39979.1 - 0.0095 15.0 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) TrkA_N PF02254.13 EFE39979.1 - 0.054 13.4 0.5 3.8 7.5 0.1 2.7 3 0 0 3 3 3 0 TrkA-N domain Mem_trans PF03547.13 EFE39980.1 - 3.6 5.7 5.7 7.5 4.7 4.0 1.6 1 0 0 1 1 1 0 Membrane transport protein Arrestin_N PF00339.24 EFE39981.1 - 0.0048 16.7 3.1 0.038 13.7 0.0 2.8 2 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.7 EFE39981.1 - 0.014 14.6 0.3 0.041 13.0 0.0 1.9 3 0 0 3 3 3 0 Bul1 C terminus Macoilin PF09726.4 EFE39982.1 - 0.61 8.2 5.1 0.59 8.3 3.5 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF566 PF04484.7 EFE39982.1 - 6.3 6.2 6.9 7.5 5.9 4.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) HD PF01966.17 EFE39983.1 - 0.0085 16.0 0.7 0.27 11.2 0.1 2.8 2 1 0 2 2 2 1 HD domain HflK_N PF12221.3 EFE39983.1 - 0.015 14.9 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial membrane protein N terminal MIF4G PF02854.14 EFE39985.1 - 4.6e-27 94.7 0.7 9.7e-27 93.7 0.1 1.9 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.12 EFE39985.1 - 4.1e-24 84.4 0.1 1.6e-23 82.5 0.0 2.0 2 0 0 2 2 2 1 MA3 domain NOA36 PF06524.7 EFE39985.1 - 2.5 7.2 7.2 4.1 6.5 5.0 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.5 EFE39985.1 - 9.6 6.5 12.3 55 4.0 7.1 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain HECT PF00632.20 EFE39986.1 - 1.1e-83 281.0 0.0 1.8e-83 280.3 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.22 EFE39986.1 - 0.0087 15.6 0.2 0.038 13.6 0.1 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif Brevenin PF03032.10 EFE39986.1 - 0.24 11.2 1.0 1 9.2 0.7 2.2 1 0 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family Utp14 PF04615.8 EFE39988.1 - 2e-209 697.4 60.8 2e-209 697.4 42.1 2.6 1 1 2 3 3 3 1 Utp14 protein TFIIF_alpha PF05793.7 EFE39989.1 - 0.059 11.7 0.5 0.065 11.6 0.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2457 PF10446.4 EFE39989.1 - 0.4 9.3 8.3 0.46 9.1 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.7 EFE39989.1 - 8 5.6 5.9 11 5.1 4.1 1.2 1 0 0 1 1 1 0 NOA36 protein Glyco_hydro_81 PF03639.8 EFE39990.1 - 6e-206 685.6 2.2 7.5e-206 685.2 1.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 Peptidase_M28 PF04389.12 EFE39991.1 - 3.7e-30 104.9 0.1 6e-30 104.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EFE39991.1 - 0.0086 15.5 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF4199 PF13858.1 EFE39992.1 - 0.067 13.1 0.0 0.089 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) SHR3_chaperone PF08229.6 EFE39995.1 - 2.3e-78 261.6 0.0 3.1e-78 261.2 0.0 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 CDC37_C PF08564.5 EFE39995.1 - 0.061 13.1 0.7 0.1 12.4 0.5 1.3 1 0 0 1 1 1 0 Cdc37 C terminal domain T_Ag_DNA_bind PF02217.11 EFE39996.1 - 0.006 16.9 0.6 0.013 15.8 0.4 1.6 1 1 0 1 1 1 1 Origin of replication binding protein Arrestin_N PF00339.24 EFE39997.1 - 4.6e-16 58.9 0.0 5.6e-14 52.2 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain MFS_1 PF07690.11 EFE39998.1 - 5e-19 68.2 53.5 8.3e-18 64.2 34.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Zip PF02535.17 EFE39999.1 - 0.27 10.1 11.0 0.33 9.9 7.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BAF1_ABF1 PF04684.8 EFE39999.1 - 0.28 9.9 8.0 0.34 9.7 5.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SelP_N PF04592.9 EFE39999.1 - 1.1 8.6 15.5 1.5 8.1 10.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region APG5 PF04106.7 EFE40000.1 - 2.2e-49 167.6 0.0 6.8e-32 110.5 0.0 2.1 1 1 1 2 2 2 2 Autophagy protein Apg5 QCR10 PF09796.4 EFE40001.1 - 1e-21 76.3 0.0 1.5e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) zf-H2C2_2 PF13465.1 EFE40002.1 - 2.3e-07 30.7 11.9 9.6e-06 25.6 1.1 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFE40002.1 - 1.9e-06 27.7 13.9 0.00018 21.5 4.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.7 EFE40002.1 - 0.00041 20.4 4.7 0.0009 19.3 3.3 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 EFE40002.1 - 0.0022 18.2 16.8 0.018 15.3 4.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 EFE40002.1 - 0.0027 17.7 4.7 0.056 13.5 0.7 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding Zn_Tnp_IS1595 PF12760.2 EFE40002.1 - 0.16 11.7 1.4 0.28 11.0 1.0 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-BED PF02892.10 EFE40002.1 - 0.17 11.6 7.4 0.15 11.8 0.6 2.6 2 0 0 2 2 2 0 BED zinc finger zf-met PF12874.2 EFE40002.1 - 0.58 10.4 5.3 1.8 8.9 0.6 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.1 EFE40002.1 - 5.5 6.7 8.4 8.6 6.1 0.7 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Myb_DNA-binding PF00249.26 EFE40004.1 - 2e-10 40.5 2.4 1.1e-07 31.8 0.1 2.7 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE40004.1 - 7.9e-08 32.2 5.1 0.00012 22.1 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Methyltransf_11 PF08241.7 EFE40006.1 - 5.1e-12 46.1 0.0 9.1e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40006.1 - 1.1e-07 31.6 0.0 3.4e-07 30.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE40006.1 - 5.4e-06 26.0 0.0 7.5e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40006.1 - 4.2e-05 23.9 0.0 7.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE40006.1 - 5.6e-05 23.4 0.0 9.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE40006.1 - 0.0011 19.5 0.0 0.002 18.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 EFE40006.1 - 0.079 12.3 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CAP_GLY PF01302.20 EFE40007.1 - 3.5e-20 71.4 0.0 5.7e-20 70.7 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 EFE40007.1 - 3.4e-13 49.6 0.0 6.2e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.18 EFE40007.1 - 1.1e-06 27.9 0.0 5.5e-06 25.6 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin family CENP-C_C PF11699.3 EFE40008.1 - 3e-27 94.4 1.0 3e-27 94.4 0.7 1.9 2 0 0 2 2 2 1 Mif2/CENP-C like Mif2_N PF15624.1 EFE40008.1 - 2.3e-20 73.5 1.3 2.3e-20 73.5 0.9 4.5 2 1 3 5 5 5 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.6 EFE40008.1 - 0.058 12.8 0.0 0.17 11.4 0.0 1.8 1 0 0 1 1 1 0 Cupin domain RNase_HII PF01351.13 EFE40009.1 - 2.1e-43 148.2 0.0 2.2e-40 138.4 0.0 2.1 1 1 1 2 2 2 2 Ribonuclease HII Pex16 PF08610.5 EFE40010.1 - 2.5e-96 322.6 0.4 8.2e-88 294.6 0.1 2.5 1 1 0 2 2 2 2 Peroxisomal membrane protein (Pex16) SAE2 PF08573.5 EFE40011.1 - 3.3e-22 78.9 2.4 3.8e-20 72.3 0.0 3.4 2 0 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Microtub_assoc PF07989.6 EFE40011.1 - 0.0017 18.1 3.7 0.049 13.4 1.1 2.7 2 1 0 2 2 2 1 Microtubule associated Phage_GP20 PF06810.6 EFE40011.1 - 0.0088 15.4 10.0 0.018 14.4 6.9 1.5 1 0 0 1 1 1 1 Phage minor structural protein GP20 EzrA PF06160.7 EFE40011.1 - 0.01 14.0 7.9 0.015 13.5 5.5 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA APG6 PF04111.7 EFE40011.1 - 0.014 14.4 11.4 0.021 13.9 7.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 ATG16 PF08614.6 EFE40011.1 - 0.014 15.1 7.4 0.043 13.6 5.1 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Nsp1_C PF05064.8 EFE40011.1 - 0.03 13.9 1.9 0.07 12.7 1.3 1.6 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF724 PF05266.9 EFE40011.1 - 0.5 9.9 7.3 1 8.9 5.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DivIC PF04977.10 EFE40011.1 - 1.1 8.8 7.0 0.57 9.6 2.4 2.0 1 1 1 2 2 2 0 Septum formation initiator DUF4407 PF14362.1 EFE40011.1 - 1.7 7.5 4.4 2.6 6.8 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IncA PF04156.9 EFE40011.1 - 4.4 6.8 12.4 8.6 5.8 8.6 1.4 1 0 0 1 1 1 0 IncA protein TMPIT PF07851.8 EFE40011.1 - 7.3 5.5 5.5 11 5.0 3.8 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF972 PF06156.8 EFE40011.1 - 9.5 6.6 11.7 8.8 6.7 3.2 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF972) WD40 PF00400.27 EFE40012.1 - 0.00094 18.9 0.1 3.8 7.5 0.1 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat CNH PF00780.17 EFE40012.1 - 0.054 12.8 0.0 0.37 10.1 0.0 1.9 2 0 0 2 2 2 0 CNH domain DUF3987 PF13148.1 EFE40013.1 - 0.79 8.2 3.2 1.1 7.7 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Cupin_8 PF13621.1 EFE40014.1 - 5.3e-16 58.8 0.0 1.2e-14 54.3 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 EFE40014.1 - 3.5e-09 36.8 0.1 0.0034 17.5 0.0 2.6 2 0 0 2 2 2 2 JmjC domain, hydroxylase F-box-like PF12937.2 EFE40014.1 - 7e-07 28.8 0.0 1.6e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE40014.1 - 0.00072 19.1 0.0 0.0017 17.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain Glyco_hydro_38 PF01074.17 EFE40015.1 - 3.5e-90 301.9 0.4 3.5e-90 301.9 0.3 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 EFE40015.1 - 5.2e-67 226.6 0.0 1e-66 225.6 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 EFE40015.1 - 7.5e-25 86.9 0.0 1.4e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase, middle domain NUDIX PF00293.23 EFE40017.1 - 4.8e-11 42.4 0.0 1.6e-10 40.7 0.0 1.8 2 0 0 2 2 2 1 NUDIX domain TRM13 PF05206.9 EFE40017.1 - 0.072 12.3 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase TRM13 GHL12 PF14882.1 EFE40017.1 - 0.11 12.6 1.1 0.26 11.4 0.8 1.6 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 12 LETM1 PF07766.8 EFE40018.1 - 2.7e-104 347.9 0.1 5.4e-104 346.9 0.1 1.5 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.22 EFE40018.1 - 0.00017 21.0 0.0 0.3 10.6 0.0 3.1 3 0 0 3 3 3 2 SAP domain DUF2838 PF10998.3 EFE40019.1 - 2.7e-41 139.9 10.7 2.7e-41 139.9 7.4 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) NFRKB_winged PF14465.1 EFE40019.1 - 0.036 13.8 0.2 3 7.7 0.0 2.6 2 1 0 2 2 2 0 NFRKB Winged Helix-like Exonuc_VII_L PF02601.10 EFE40019.1 - 0.19 10.9 1.7 0.27 10.3 1.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.9 EFE40019.1 - 1.9 8.4 7.0 0.52 10.2 2.2 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF106 PF01956.11 EFE40019.1 - 8.4 5.8 9.0 2.9 7.4 3.4 2.2 2 1 0 2 2 2 0 Integral membrane protein DUF106 Complex1_30kDa PF00329.14 EFE40022.1 - 2.3e-36 124.1 0.1 3.3e-36 123.6 0.1 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit PLU-1 PF08429.6 EFE40023.1 - 2.8e-98 328.9 16.9 3e-97 325.5 10.1 2.3 2 0 0 2 2 2 1 PLU-1-like protein JmjC PF02373.17 EFE40023.1 - 5.5e-42 142.6 1.2 1.6e-41 141.1 0.2 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.16 EFE40023.1 - 3.8e-27 93.9 0.1 1.3e-26 92.2 0.0 2.0 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.12 EFE40023.1 - 1.1e-18 66.4 2.4 2.4e-18 65.3 1.7 1.6 1 0 0 1 1 1 1 jmjN domain PHD PF00628.24 EFE40023.1 - 6e-18 64.2 27.9 1.4e-09 37.4 4.9 3.5 3 0 0 3 3 3 2 PHD-finger zf-C5HC2 PF02928.11 EFE40023.1 - 9.4e-14 51.2 4.7 2.5e-13 49.8 3.2 1.8 1 0 0 1 1 1 1 C5HC2 zinc finger zf-PHD-like PF15446.1 EFE40023.1 - 0.072 12.3 13.1 0.053 12.8 1.0 2.9 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.17 EFE40023.1 - 2.6 7.8 24.1 0.14 11.9 2.3 3.3 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FANCL_C PF11793.3 EFE40024.1 - 1e-05 25.3 4.6 1.7e-05 24.7 3.2 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.1 EFE40024.1 - 0.017 15.0 0.8 0.028 14.4 0.5 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFE40024.1 - 0.051 13.7 2.1 0.086 12.9 1.5 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain Prok-RING_1 PF14446.1 EFE40024.1 - 0.065 12.9 4.7 0.086 12.5 1.6 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.6 EFE40024.1 - 4.4 7.3 8.1 24 5.0 4.9 2.3 1 1 1 2 2 2 0 RING-like domain Thymidylate_kin PF02223.12 EFE40025.1 - 3.5e-26 91.7 0.0 4.1e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.1 EFE40025.1 - 0.024 14.5 0.0 0.028 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain TGT PF01702.13 EFE40026.1 - 6.7e-39 133.5 0.0 9.2e-39 133.1 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase MFS_1 PF07690.11 EFE40027.1 - 1.7e-15 56.5 7.3 1.7e-15 56.5 5.0 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40027.1 - 1.7e-12 46.6 7.2 3.2e-12 45.7 5.0 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.15 EFE40027.1 - 0.0035 15.4 1.1 0.0082 14.2 0.2 1.9 1 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF3938 PF13074.1 EFE40027.1 - 0.058 13.2 0.3 0.24 11.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3938) MTHFR PF02219.12 EFE40028.1 - 4.6e-102 340.9 0.0 7.6e-102 340.2 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase FLILHELTA PF10306.4 EFE40029.1 - 2.2e-26 91.7 0.0 4.1e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.8 EFE40029.1 - 0.0053 17.0 0.2 0.0073 16.5 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) NDK PF00334.14 EFE40030.1 - 5.8e-24 84.4 0.0 1.9e-17 63.3 0.0 2.0 1 1 1 2 2 2 2 Nucleoside diphosphate kinase Glyco_hydro_31 PF01055.21 EFE40031.1 - 1.6e-147 491.9 8.6 2.3e-147 491.4 6.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 EFE40031.1 - 3e-25 87.8 0.4 8.3e-25 86.4 0.1 1.9 2 0 0 2 2 2 1 Galactose mutarotase-like NMT1 PF09084.6 EFE40033.1 - 0.0036 16.9 0.0 0.05 13.1 0.0 2.3 1 1 1 2 2 2 1 NMT1/THI5 like SBP_bac_3 PF00497.15 EFE40033.1 - 0.049 12.8 0.0 0.15 11.2 0.0 1.7 1 1 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 XPA_C PF05181.7 EFE40033.1 - 0.088 12.4 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 XPA protein C-terminus Phe_hydrox_dim PF07976.7 EFE40034.1 - 3.6e-19 69.0 0.0 1.9e-18 66.6 0.0 2.1 2 1 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_3 PF01494.14 EFE40034.1 - 1.4e-08 34.1 0.0 2.1e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 EFE40035.1 - 1.2e-29 103.5 0.0 6.2e-28 97.8 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Glyco_hydro_16 PF00722.16 EFE40036.1 - 3.1e-06 26.6 0.0 7e-06 25.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Ribosomal_L1 PF00687.16 EFE40037.1 - 3.5e-33 114.7 0.0 5.6e-33 114.1 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family COG2 PF06148.6 EFE40038.1 - 8.3e-30 103.3 1.1 1.8e-29 102.3 0.7 1.5 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.6 EFE40038.1 - 1.6e-05 24.6 2.5 2.6e-05 23.9 0.2 2.4 1 1 1 2 2 2 1 Vps51/Vps67 COG5 PF10392.4 EFE40038.1 - 0.021 14.7 0.4 0.021 14.7 0.3 1.8 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Spc7 PF08317.6 EFE40038.1 - 0.021 13.4 2.2 0.04 12.5 1.5 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Sec8_exocyst PF04048.9 EFE40038.1 - 0.034 13.7 0.6 0.089 12.4 0.4 1.7 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF2450 PF10475.4 EFE40038.1 - 0.038 12.8 0.9 0.051 12.4 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function N-terminal domain (DUF2450) Seryl_tRNA_N PF02403.17 EFE40038.1 - 0.044 13.7 2.0 1.5 8.8 0.1 2.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Dor1 PF04124.7 EFE40038.1 - 0.049 12.0 1.3 0.069 11.6 0.9 1.2 1 0 0 1 1 1 0 Dor1-like family Atg14 PF10186.4 EFE40038.1 - 0.1 11.5 2.4 0.17 10.7 1.6 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Bul1_C PF04426.7 EFE40038.1 - 0.1 11.7 0.9 3.7 6.6 0.0 2.2 1 1 1 2 2 2 0 Bul1 C terminus ING PF12998.2 EFE40038.1 - 0.11 12.7 5.0 1.3 9.2 1.5 2.7 2 2 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding IncA PF04156.9 EFE40038.1 - 0.32 10.5 5.1 0.85 9.1 3.5 1.7 1 0 0 1 1 1 0 IncA protein Sigma70_ner PF04546.8 EFE40038.1 - 0.61 9.6 5.1 0.18 11.3 1.3 1.8 2 1 0 2 2 2 0 Sigma-70, non-essential region TBPIP PF07106.8 EFE40038.1 - 0.7 9.4 8.5 3.3 7.2 0.6 2.7 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 EFE40038.1 - 1.2 9.5 4.5 2.5 8.4 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) ParA PF10609.4 EFE40041.1 - 2.6e-35 120.1 0.1 4.7e-35 119.3 0.0 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EFE40041.1 - 1.8e-14 53.5 0.0 3.9e-14 52.5 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 EFE40041.1 - 7.4e-06 25.2 0.0 0.00014 20.9 0.0 2.0 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.1 EFE40041.1 - 3.3e-05 23.8 0.0 0.00014 21.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.10 EFE40041.1 - 0.00017 20.7 0.2 0.0012 17.9 0.2 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.1 EFE40041.1 - 0.0019 17.6 0.2 0.0039 16.6 0.0 1.5 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EFE40041.1 - 0.019 13.7 0.1 0.031 13.0 0.1 1.2 1 0 0 1 1 1 0 ArgK protein AAA_26 PF13500.1 EFE40041.1 - 0.02 14.5 0.4 4.2 6.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain YhjQ PF06564.7 EFE40041.1 - 0.025 13.9 0.1 0.055 12.8 0.0 1.6 2 0 0 2 2 2 0 YhjQ protein OrfB_Zn_ribbon PF07282.6 EFE40041.1 - 0.032 13.8 0.2 0.061 12.9 0.1 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain AAA_10 PF12846.2 EFE40041.1 - 0.073 12.4 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain APS_kinase PF01583.15 EFE40041.1 - 0.14 11.8 0.1 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF258 PF03193.11 EFE40041.1 - 0.21 10.7 0.9 0.34 10.0 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SEP PF08059.8 EFE40042.1 - 1.6e-26 92.3 0.1 3e-26 91.5 0.1 1.5 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 EFE40042.1 - 1.2e-14 54.0 0.0 2e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 EFE40042.1 - 3.2e-07 29.7 0.1 2.7e-06 26.7 0.1 2.2 1 1 0 1 1 1 1 UBA-like domain Ribosomal_60s PF00428.14 EFE40042.1 - 0.52 10.7 9.2 0.84 10.0 0.1 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein 60KD_IMP PF02096.15 EFE40043.1 - 6e-32 110.9 0.2 1e-31 110.1 0.0 1.4 2 0 0 2 2 2 1 60Kd inner membrane protein TAFII28 PF04719.9 EFE40044.1 - 1.3e-21 76.2 0.1 7e-21 73.8 0.0 2.0 2 0 0 2 2 2 1 hTAFII28-like protein conserved region FAD_binding_3 PF01494.14 EFE40046.1 - 8.5e-12 44.7 1.7 0.00074 18.6 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain DAO PF01266.19 EFE40046.1 - 1.5e-07 30.6 2.3 0.003 16.5 0.6 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFE40046.1 - 2.5e-06 26.5 0.2 4.4e-06 25.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFE40046.1 - 0.00028 20.8 0.9 0.00099 19.0 0.6 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE40046.1 - 0.0012 17.4 0.8 0.0034 15.8 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.16 EFE40046.1 - 0.0035 16.9 0.1 0.0057 16.2 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.1 EFE40046.1 - 0.0056 16.6 0.2 0.014 15.4 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 EFE40046.1 - 0.015 14.1 0.3 0.024 13.5 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFE40046.1 - 0.027 13.5 0.1 0.044 12.8 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.12 EFE40046.1 - 0.063 12.3 1.6 0.17 10.9 0.2 2.0 2 0 0 2 2 2 0 Thi4 family Trp_DMAT PF11991.3 EFE40047.1 - 1.7e-105 353.1 0.0 2.1e-105 352.8 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Pkinase PF00069.20 EFE40048.1 - 6.1e-23 81.2 0.0 8.3e-23 80.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40048.1 - 7.6e-06 25.1 0.0 0.0052 15.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase WLM PF08325.5 EFE40049.1 - 2e-60 203.8 0.1 3e-60 203.2 0.1 1.3 1 0 0 1 1 1 1 WLM domain zf-RanBP PF00641.13 EFE40049.1 - 2.8e-05 23.1 1.3 2.8e-05 23.1 0.9 3.1 2 1 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF45 PF01863.12 EFE40049.1 - 0.0012 18.6 2.0 0.0026 17.6 1.4 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF45 SprT-like PF10263.4 EFE40049.1 - 0.013 15.1 0.1 0.013 15.1 0.1 2.5 2 1 0 2 2 2 0 SprT-like family Peptidase_M54 PF07998.6 EFE40049.1 - 0.018 14.8 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 DUF955 PF06114.8 EFE40049.1 - 0.08 12.6 0.7 0.17 11.6 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF955) DZR PF12773.2 EFE40049.1 - 0.92 9.3 8.5 2.9 7.7 1.5 2.5 2 0 0 2 2 2 0 Double zinc ribbon Ribosomal_L19e PF01280.15 EFE40050.1 - 0.053 13.2 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L19e DUF1776 PF08643.5 EFE40051.1 - 3.2e-72 243.1 0.1 6.2e-51 173.2 0.0 2.0 1 1 1 2 2 2 2 Fungal family of unknown function (DUF1776) 7tm_7 PF08395.7 EFE40052.1 - 1.8 7.5 17.1 1.9 7.4 10.5 1.8 1 1 1 2 2 2 0 7tm Chemosensory receptor PgaD PF13994.1 EFE40052.1 - 2.6 7.5 10.5 2.3 7.6 2.5 2.5 2 1 0 2 2 2 0 PgaD-like protein EphA2_TM PF14575.1 EFE40053.1 - 0.11 12.9 3.2 0.35 11.2 0.0 2.7 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TFIIA PF03153.8 EFE40053.1 - 2 8.2 18.2 2.4 7.9 12.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myc_target_1 PF15179.1 EFE40053.1 - 6.8 6.2 7.8 14 5.1 4.7 2.2 1 1 0 1 1 1 0 Myc target protein 1 Glyco_hydro_18 PF00704.23 EFE40054.1 - 4.7e-20 72.3 0.2 1.3e-18 67.5 0.0 2.1 1 1 0 2 2 2 2 Glycosyl hydrolases family 18 Sel1 PF08238.7 EFE40055.1 - 1.2e-14 54.4 10.8 9.8e-06 26.0 2.2 4.3 4 0 0 4 4 4 3 Sel1 repeat BSMAP PF12280.3 EFE40056.1 - 0.0031 17.4 0.4 0.0043 16.9 0.3 1.2 1 0 0 1 1 1 1 Brain specific membrane anchored protein BLVR PF06375.6 EFE40056.1 - 0.0062 16.3 13.3 0.0082 15.9 9.2 1.3 1 0 0 1 1 1 1 Bovine leukaemia virus receptor (BLVR) Ribosomal_60s PF00428.14 EFE40056.1 - 0.04 14.3 1.4 0.04 14.3 1.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein FAM60A PF15396.1 EFE40056.1 - 0.15 11.7 7.1 0.17 11.6 4.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.9 EFE40056.1 - 0.28 9.1 15.5 0.32 8.9 10.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Rtf2 PF04641.7 EFE40056.1 - 0.46 9.6 11.8 0.54 9.4 8.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Pox_Ag35 PF03286.9 EFE40056.1 - 0.94 8.9 16.6 1.2 8.6 11.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1510 PF07423.6 EFE40056.1 - 1.3 8.3 14.0 1.6 8.0 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FLO_LFY PF01698.11 EFE40056.1 - 2 7.1 12.8 2.3 6.9 8.9 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Ycf1 PF05758.7 EFE40056.1 - 4.5 4.8 9.0 4.9 4.7 6.3 1.0 1 0 0 1 1 1 0 Ycf1 Hid1 PF12722.2 EFE40056.1 - 4.7 4.7 7.0 5.3 4.6 4.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NARP1 PF12569.3 EFE40056.1 - 4.7 5.8 11.1 5.3 5.6 7.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MIP-T3 PF10243.4 EFE40056.1 - 5.2 5.4 25.5 6 5.2 17.7 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Pex16 PF08610.5 EFE40056.1 - 6.7 5.6 6.9 8 5.3 4.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) U79_P34 PF03064.11 EFE40056.1 - 7.2 6.0 21.7 9.7 5.6 15.0 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 GAGA_bind PF06217.7 EFE40056.1 - 7.3 6.4 11.0 8.4 6.2 7.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Spore_coat_CotO PF14153.1 EFE40056.1 - 8 5.8 15.5 10 5.5 10.8 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Bap31 PF05529.7 EFE40056.1 - 9.8 5.5 8.3 14 5.1 5.7 1.3 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF3712 PF12505.3 EFE40057.1 - 1.4e-32 112.2 5.5 4.1e-32 110.8 2.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) LEA_2 PF03168.8 EFE40057.1 - 0.081 13.3 0.4 1.9 8.9 0.1 2.5 2 1 0 2 2 2 0 Late embryogenesis abundant protein ATP-synt_8 PF00895.15 EFE40057.1 - 0.21 11.8 1.1 0.48 10.6 0.8 1.6 1 0 0 1 1 1 0 ATP synthase protein 8 Glyco_hydro_18 PF00704.23 EFE40058.1 - 3.2e-80 270.1 0.0 3.7e-80 269.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 zf-CCCH PF00642.19 EFE40059.1 - 1.3e-18 66.2 29.5 9.1e-07 28.4 0.5 5.3 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3H1 PF10650.4 EFE40059.1 - 0.31 10.5 6.7 2 7.9 0.3 3.3 2 0 0 2 2 2 0 Putative zinc-finger domain CC PF04942.9 EFE40059.1 - 1.3 8.9 0.1 1.3 8.9 0.0 2.9 3 0 0 3 3 3 0 CC domain Syja_N PF02383.13 EFE40060.1 - 7.8e-91 304.1 0.0 9.8e-91 303.8 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Mur_ligase_M PF08245.7 EFE40061.1 - 1.3e-07 31.8 1.0 1.2e-06 28.7 0.2 2.8 2 1 0 2 2 2 1 Mur ligase middle domain NMT PF01233.14 EFE40062.1 - 4.5e-23 81.6 0.3 7e-23 81.0 0.2 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain ATP-grasp_5 PF13549.1 EFE40062.1 - 0.078 12.1 0.0 0.14 11.3 0.0 1.4 2 0 0 2 2 2 0 ATP-grasp domain TauD PF02668.11 EFE40062.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family NMT_C PF02799.10 EFE40063.1 - 1.9e-65 219.7 2.8 2.2e-65 219.6 1.9 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain STN1_2 PF09170.5 EFE40063.1 - 0.17 11.6 1.4 1.8 8.2 1.0 2.1 1 1 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 TLD PF07534.11 EFE40064.1 - 2.7e-21 75.9 0.0 4.9e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 TLD R3H-assoc PF13902.1 EFE40065.1 - 0.6 10.0 0.0 0.6 10.0 0.0 3.0 4 0 0 4 4 4 0 R3H-associated N-terminal domain Abhydrolase_5 PF12695.2 EFE40066.1 - 1.8e-13 50.5 0.0 3.2e-13 49.6 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE40066.1 - 2.7e-13 50.3 0.1 3.7e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFE40066.1 - 2.2e-05 24.1 0.0 3.4e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 EFE40066.1 - 0.0001 21.9 0.0 0.00024 20.7 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF818 PF05677.7 EFE40066.1 - 0.0029 16.4 0.0 0.0046 15.7 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Hydrolase_4 PF12146.3 EFE40066.1 - 0.014 15.2 0.1 0.033 14.0 0.0 1.6 1 1 0 1 1 1 0 Putative lysophospholipase Peptidase_S9 PF00326.16 EFE40066.1 - 0.11 11.6 0.0 0.26 10.4 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family BRX PF08381.6 EFE40066.1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 GTP_EFTU PF00009.22 EFE40067.1 - 8.4e-56 188.3 0.3 1.6e-55 187.4 0.2 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 EFE40067.1 - 2.4e-32 110.5 0.0 4.9e-32 109.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 EFE40067.1 - 2.4e-30 104.5 0.0 4.8e-30 103.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 EFE40067.1 - 2.7e-24 84.8 0.0 7.1e-24 83.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFE40067.1 - 3.2e-12 46.3 0.0 9.3e-12 44.8 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 ATP_bind_1 PF03029.12 EFE40067.1 - 0.027 14.0 0.1 0.11 11.9 0.1 2.1 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein PALP PF00291.20 EFE40068.1 - 4.8e-69 232.9 1.0 6e-69 232.5 0.7 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 EFE40068.1 - 3.3e-43 145.1 0.0 7.4e-21 73.5 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase HIG_1_N PF04588.8 EFE40069.1 - 2.1e-22 78.6 0.2 3.6e-22 77.8 0.2 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region OPA3 PF07047.7 EFE40069.1 - 0.059 13.1 0.4 0.096 12.4 0.3 1.4 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) DUF2681 PF10883.3 EFE40069.1 - 0.1 12.8 2.0 0.18 12.0 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Acetyltransf_1 PF00583.19 EFE40070.1 - 5.2e-16 58.4 0.0 7.9e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFE40070.1 - 2.9e-06 26.9 0.0 5.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 EFE40070.1 - 4.2e-06 26.8 0.0 6.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EFE40070.1 - 3.1e-05 23.9 0.0 5.3e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE40070.1 - 0.00025 21.1 0.0 0.00037 20.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFE40070.1 - 0.00063 19.9 0.0 0.00086 19.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pescadillo_N PF06732.6 EFE40071.1 - 7.2e-89 297.7 0.0 7.2e-89 297.7 0.0 2.8 3 0 0 3 3 3 1 Pescadillo N-terminus BRCT PF00533.21 EFE40071.1 - 3.8e-06 26.9 0.0 0.00011 22.2 0.0 3.0 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RRN9 PF10680.4 EFE40072.1 - 2e-18 65.8 0.0 5.2e-18 64.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor zf-C2H2_4 PF13894.1 EFE40072.1 - 0.0039 17.4 0.3 0.014 15.6 0.2 2.0 1 0 0 1 1 1 1 C2H2-type zinc finger Aldedh PF00171.17 EFE40073.1 - 2.5e-156 520.6 0.3 3e-156 520.3 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_S11 PF00411.14 EFE40073.1 - 0.073 13.2 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein S11 Raffinose_syn PF05691.7 EFE40074.1 - 6.4e-55 186.0 1.5 9.7e-51 172.2 0.7 4.1 3 1 0 3 3 3 2 Raffinose synthase or seed imbibition protein Sip1 Melibiase PF02065.13 EFE40074.1 - 9e-06 24.6 0.0 1.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Melibiase tRNA-synt_1b PF00579.20 EFE40075.1 - 3.5e-56 190.4 0.0 4.6e-56 190.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) MutS_V PF00488.16 EFE40076.1 - 6.9e-80 267.8 0.0 1.1e-79 267.1 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFE40076.1 - 2.7e-52 177.5 0.1 5.4e-52 176.5 0.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EFE40076.1 - 2.2e-33 114.6 0.1 1.3e-32 112.2 0.1 2.2 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.13 EFE40076.1 - 6.5e-16 58.2 2.0 1.8e-15 56.8 1.4 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 EFE40076.1 - 2.8e-12 46.8 0.0 9.7e-12 45.1 0.0 2.0 1 0 0 1 1 1 1 MutS domain II AAA_23 PF13476.1 EFE40076.1 - 0.0048 17.2 4.9 0.026 14.8 0.1 2.8 2 0 0 2 2 2 1 AAA domain SPT6_acidic PF14632.1 EFE40076.1 - 0.01 15.9 11.1 0.01 15.9 7.7 3.1 2 1 1 3 3 3 0 Acidic N-terminal SPT6 AAA_29 PF13555.1 EFE40076.1 - 0.026 14.0 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 EFE40076.1 - 0.051 13.5 1.0 0.14 12.1 0.1 2.1 2 0 0 2 2 2 0 AAA domain HTH_20 PF12840.2 EFE40077.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Peptidase_M28 PF04389.12 EFE40078.1 - 2.5e-33 115.3 0.0 3.6e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Sulf_transp PF04143.9 EFE40079.1 - 1.4e-12 47.4 25.1 1e-08 35.0 5.3 3.7 4 0 0 4 4 4 2 Sulphur transport DUF4341 PF14241.1 EFE40079.1 - 2.3e-09 36.7 0.3 2.3e-09 36.7 0.2 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4341) LigD_N PF13298.1 EFE40080.1 - 5.4e-24 84.3 0.1 1.2e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase Ligase (LigD) UDG PF03167.14 EFE40080.1 - 0.0037 16.7 0.0 0.0076 15.7 0.0 1.5 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily NST1 PF13945.1 EFE40080.1 - 0.18 11.8 3.6 0.37 10.8 2.5 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator P_C PF06640.6 EFE40080.1 - 2.3 8.1 7.7 3.4 7.6 1.9 2.2 2 0 0 2 2 2 0 P protein C-terminus PhoD PF09423.5 EFE40081.1 - 1.9e-149 498.1 0.2 2.3e-149 497.8 0.2 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase ABC_tran PF00005.22 EFE40082.1 - 5.3e-49 166.0 0.0 1.3e-31 109.7 0.0 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFE40082.1 - 6.1e-32 111.1 32.7 4.9e-19 68.8 10.6 2.8 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.14 EFE40082.1 - 1.9e-12 46.9 0.0 0.0031 16.7 0.0 4.3 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFE40082.1 - 8.7e-08 32.7 1.0 1.4e-05 25.4 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFE40082.1 - 1.5e-05 24.5 0.1 0.14 11.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFE40082.1 - 5.3e-05 23.2 0.5 0.067 13.1 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain T2SE PF00437.15 EFE40082.1 - 7.7e-05 21.7 0.0 0.024 13.5 0.0 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.1 EFE40082.1 - 8.9e-05 22.6 0.1 1.4 9.1 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.1 EFE40082.1 - 0.00011 21.6 4.3 0.04 13.4 0.1 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain DUF258 PF03193.11 EFE40082.1 - 0.0003 20.0 0.0 0.8 8.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_21 PF13304.1 EFE40082.1 - 0.00045 20.2 1.5 1.4 8.8 0.0 4.0 2 2 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EFE40082.1 - 0.00051 19.9 0.0 0.21 11.5 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.7 EFE40082.1 - 0.0031 16.6 0.1 0.72 8.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Miro PF08477.8 EFE40082.1 - 0.0032 17.9 0.1 5.2 7.5 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_10 PF12846.2 EFE40082.1 - 0.0041 16.5 0.4 2.9 7.2 0.0 2.7 2 1 0 2 2 2 2 AAA-like domain DUF87 PF01935.12 EFE40082.1 - 0.0042 16.9 2.3 0.62 9.8 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_17 PF13207.1 EFE40082.1 - 0.021 15.6 0.2 6.6 7.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 EFE40082.1 - 0.044 13.2 0.1 2.1 7.7 0.0 2.8 3 0 0 3 3 2 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.13 EFE40082.1 - 0.055 12.9 0.0 7.8 5.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Orthoreo_P10 PF07204.6 EFE40082.1 - 0.057 13.1 0.7 21 4.9 0.4 3.3 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 AAA_30 PF13604.1 EFE40082.1 - 0.066 12.7 0.5 15 5.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF2075 PF09848.4 EFE40082.1 - 0.13 11.2 0.1 2 7.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ArgK PF03308.11 EFE40082.1 - 0.14 10.9 0.0 0.3 9.8 0.0 1.5 1 0 0 1 1 1 0 ArgK protein Herpes_UL45 PF05473.7 EFE40082.1 - 0.15 11.4 0.2 0.34 10.3 0.2 1.6 1 0 0 1 1 1 0 UL45 protein PEP_mutase PF13714.1 EFE40083.1 - 6.2e-67 225.2 1.1 7e-67 225.1 0.7 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF1127 PF06568.6 EFE40083.1 - 0.057 12.8 0.3 0.82 9.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) tRNA-synt_2 PF00152.15 EFE40086.1 - 6.9e-103 343.9 0.0 1.3e-102 343.0 0.0 1.3 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFE40086.1 - 1.1e-05 25.2 0.0 3.1e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.20 EFE40086.1 - 0.0017 17.9 0.1 0.0034 16.9 0.1 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ABC2_membrane PF01061.19 EFE40087.1 - 1.6e-26 92.7 26.9 2.2e-26 92.3 18.7 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 EFE40087.1 - 3.9e-26 91.9 0.2 2e-25 89.7 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 EFE40087.1 - 3.4e-09 37.0 0.1 1.1e-06 28.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFE40087.1 - 3.5e-05 23.0 0.1 6e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.2 EFE40087.1 - 0.0002 20.4 14.3 0.00029 20.0 9.9 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_16 PF13191.1 EFE40087.1 - 0.00042 20.3 0.0 0.00078 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 EFE40087.1 - 0.00047 19.6 0.6 0.00096 18.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE40087.1 - 0.00086 19.0 0.0 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain cobW PF02492.14 EFE40087.1 - 0.0029 17.0 0.0 0.0063 15.9 0.0 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 EFE40087.1 - 0.0039 16.6 0.1 0.0084 15.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 EFE40087.1 - 0.0053 17.5 0.0 0.012 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFE40087.1 - 0.0057 16.8 0.8 0.016 15.3 0.1 2.3 2 1 0 2 2 1 1 AAA domain T2SE PF00437.15 EFE40087.1 - 0.0062 15.4 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA PF00004.24 EFE40087.1 - 0.0077 16.4 0.0 0.074 13.2 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 EFE40087.1 - 0.011 15.4 0.3 0.025 14.2 0.0 1.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_15 PF13175.1 EFE40087.1 - 0.012 14.7 0.0 2.5 7.0 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain SMC_N PF02463.14 EFE40087.1 - 0.018 14.3 0.6 0.03 13.5 0.0 1.6 2 0 0 2 2 1 0 RecF/RecN/SMC N terminal domain AAA_33 PF13671.1 EFE40087.1 - 0.02 14.7 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFE40087.1 - 0.02 14.8 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFE40087.1 - 0.021 15.1 0.0 0.052 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EFE40087.1 - 0.023 14.2 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EFE40087.1 - 0.031 13.6 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.7 EFE40087.1 - 0.039 13.5 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_10 PF12846.2 EFE40087.1 - 0.042 13.2 0.3 0.083 12.3 0.1 1.6 2 0 0 2 2 1 0 AAA-like domain SbcCD_C PF13558.1 EFE40087.1 - 0.045 13.6 0.0 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit PduV-EutP PF10662.4 EFE40087.1 - 0.048 13.1 0.0 0.12 11.8 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.10 EFE40087.1 - 0.054 12.1 0.0 0.089 11.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein UPF0079 PF02367.12 EFE40087.1 - 0.057 13.0 0.1 0.19 11.3 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF2304 PF10066.4 EFE40087.1 - 0.096 12.5 4.1 0.37 10.6 2.9 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) RNA_helicase PF00910.17 EFE40087.1 - 0.11 12.7 0.0 0.65 10.1 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_13 PF13166.1 EFE40087.1 - 0.34 9.3 4.7 0.38 9.1 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.1 EFE40087.1 - 0.58 10.4 3.1 2.2 8.5 2.1 2.1 1 1 0 1 1 1 0 AAA domain Zn_clus PF00172.13 EFE40088.1 - 1.7e-08 34.2 4.4 3.3e-08 33.3 3.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFE40088.1 - 2.1e-08 33.3 0.3 4.5e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain GFA PF04828.9 EFE40089.1 - 1.1e-19 70.1 0.5 1.1e-19 70.1 0.4 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme ThiS PF02597.15 EFE40090.1 - 0.00032 21.0 0.0 0.0031 17.9 0.0 1.9 1 1 0 1 1 1 1 ThiS family Cys_Met_Meta_PP PF01053.15 EFE40091.1 - 8.6e-61 205.3 0.0 3.8e-60 203.1 0.0 2.0 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EFE40091.1 - 0.0069 15.1 0.0 0.013 14.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFE40091.1 - 0.025 13.6 0.1 0.25 10.3 0.0 2.0 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Rab5-bind PF09311.6 EFE40092.1 - 0.043 13.7 1.0 0.045 13.6 0.7 1.0 1 0 0 1 1 1 0 Rabaptin-like protein Pex16 PF08610.5 EFE40092.1 - 0.11 11.4 0.4 0.12 11.3 0.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) TRP PF06011.7 EFE40094.1 - 8.8e-90 301.3 26.5 3e-89 299.6 18.4 1.8 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EFE40094.1 - 5.6e-15 55.5 0.1 9.5e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 ML-like domain Strabismus PF06638.6 EFE40094.1 - 2 6.6 6.5 3.8 5.7 4.5 1.3 1 0 0 1 1 1 0 Strabismus protein APH PF01636.18 EFE40095.1 - 7.7e-16 58.5 0.5 1.8e-15 57.3 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family DNA_binding_1 PF01035.15 EFE40096.1 - 4.3e-23 80.8 0.0 5.9e-23 80.4 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Rubella_Capsid PF05750.6 EFE40096.1 - 0.0027 17.1 0.2 0.0046 16.4 0.0 1.4 2 0 0 2 2 2 1 Rubella capsid protein Sugar_tr PF00083.19 EFE40097.1 - 4e-61 206.9 17.3 2.3e-42 145.1 1.6 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter Pyr_redox_dim PF02852.17 EFE40097.1 - 2.1e-38 130.7 0.1 5e-38 129.5 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 EFE40097.1 - 1.8e-36 125.9 16.9 3.7e-35 121.6 11.7 3.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE40097.1 - 4.9e-21 74.9 13.0 2.4e-20 72.6 0.8 3.2 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.11 EFE40097.1 - 1.9e-13 49.8 31.6 2.3e-07 29.8 5.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily FAD_oxidored PF12831.2 EFE40097.1 - 3.4e-10 39.5 7.8 3.6e-10 39.4 0.1 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE40097.1 - 1.9e-08 34.2 5.2 0.00015 21.6 0.4 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 EFE40097.1 - 1.5e-07 30.6 12.5 8.2e-07 28.2 3.2 2.7 2 2 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 EFE40097.1 - 2.6e-07 30.9 0.1 1.9e-05 24.8 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFE40097.1 - 8.7e-07 28.1 2.6 8.7e-07 28.1 1.8 2.5 2 1 0 2 2 2 1 FAD binding domain DAO PF01266.19 EFE40097.1 - 4.6e-06 25.7 15.4 0.0011 17.9 0.3 3.5 2 1 1 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 EFE40097.1 - 5.4e-05 22.2 0.5 0.2 10.5 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 EFE40097.1 - 8e-05 21.8 4.9 0.00044 19.4 0.1 2.4 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.16 EFE40097.1 - 0.00011 21.7 2.3 0.026 14.0 0.1 2.7 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.9 EFE40097.1 - 0.00016 20.3 13.6 0.001 17.6 1.0 3.9 4 0 0 4 4 4 2 HI0933-like protein Lycopene_cycl PF05834.7 EFE40097.1 - 0.0026 16.7 0.3 0.048 12.5 0.0 2.5 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 EFE40097.1 - 0.039 13.0 11.4 0.3 10.0 1.0 3.4 3 1 0 3 3 3 0 FAD binding domain THF_DHG_CYH_C PF02882.14 EFE40097.1 - 0.057 12.4 2.3 0.2 10.7 0.1 2.6 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.1 EFE40097.1 - 0.24 11.6 1.6 4.6 7.5 0.1 2.9 2 0 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 EFE40097.1 - 9.2 5.8 8.8 0.39 10.3 0.7 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PGM_PMM_II PF02879.11 EFE40098.1 - 3.5e-16 59.3 0.1 8.7e-16 58.1 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 EFE40098.1 - 6e-15 55.2 0.0 9.9e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 EFE40098.1 - 2e-08 34.0 0.0 4.4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Peripla_BP_4 PF13407.1 EFE40098.1 - 0.057 12.7 0.0 0.12 11.6 0.0 1.5 2 0 0 2 2 2 0 Periplasmic binding protein domain PGM_PMM_I PF02878.11 EFE40099.1 - 2.3e-26 91.8 0.1 3e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I FA_desaturase PF00487.19 EFE40100.1 - 1e-34 120.1 29.8 1.6e-34 119.5 20.7 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 EFE40100.1 - 1.4e-12 47.1 0.0 3.2e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CUE PF02845.11 EFE40101.1 - 7.1e-10 38.1 0.0 1.6e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 CUE domain GldM_N PF12081.3 EFE40101.1 - 0.0073 15.8 0.1 0.11 12.0 0.0 2.5 3 0 0 3 3 3 1 GldM N-terminal domain Ribosomal_S10 PF00338.17 EFE40102.1 - 3.2e-28 97.4 0.5 3.8e-28 97.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Nucleoporin_FG PF13634.1 EFE40103.1 - 0.41 10.8 84.4 5.8 7.1 38.5 3.4 1 1 2 3 3 3 0 Nucleoporin FG repeat region ELYS PF13934.1 EFE40104.1 - 1.7e-70 237.2 0.0 8.8e-69 231.6 0.0 2.1 1 1 0 1 1 1 1 Nuclear pore complex assembly SMC_N PF02463.14 EFE40105.1 - 3e-74 248.9 13.6 9.5e-74 247.3 9.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EFE40105.1 - 1.9e-28 98.8 0.3 1.3e-27 96.1 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 EFE40105.1 - 6.5e-11 42.7 10.7 3.2e-05 24.0 0.1 3.2 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFE40105.1 - 0.00025 20.5 0.0 0.00053 19.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 EFE40105.1 - 0.00034 19.8 1.1 0.00034 19.8 0.7 5.3 3 2 2 6 6 6 3 Reovirus sigma C capsid protein Filament PF00038.16 EFE40105.1 - 0.00064 19.2 14.6 0.00064 19.2 10.1 5.2 2 2 1 4 4 4 1 Intermediate filament protein ATG16 PF08614.6 EFE40105.1 - 0.0024 17.7 17.2 0.0024 17.7 11.9 8.1 3 2 5 8 8 8 1 Autophagy protein 16 (ATG16) Fib_alpha PF08702.5 EFE40105.1 - 0.0038 17.3 9.9 0.0038 17.3 6.9 6.8 3 2 7 10 10 10 2 Fibrinogen alpha/beta chain family CRCB PF02537.10 EFE40105.1 - 0.26 11.1 0.0 0.49 10.3 0.0 1.3 1 0 0 1 1 1 0 CrcB-like protein Fungal_trans PF04082.13 EFE40106.1 - 2e-10 40.0 0.4 4.7e-10 38.7 0.3 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE40106.1 - 3.2e-08 33.3 4.6 6.1e-08 32.4 3.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trypan_PARP PF05887.6 EFE40106.1 - 8.1 6.2 15.3 17 5.2 10.6 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Suc_Fer-like PF06999.7 EFE40107.1 - 4.6e-46 157.7 0.0 5.4e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like WD40 PF00400.27 EFE40108.1 - 1.6e-09 37.2 3.9 0.0011 18.7 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat Ribonuc_L-PSP PF01042.16 EFE40108.1 - 1.6e-08 34.3 0.1 3e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1777 PF08648.7 EFE40108.1 - 4.1 7.0 17.1 7.6 6.2 11.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Fer4_13 PF13370.1 EFE40109.1 - 0.12 12.8 2.7 3.5 8.0 0.3 3.9 3 2 0 3 3 3 0 4Fe-4S single cluster domain Sugar_tr PF00083.19 EFE40110.1 - 4.6e-101 338.6 24.3 5.5e-101 338.3 16.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE40110.1 - 3.1e-24 85.3 38.0 1.5e-15 56.8 7.4 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 EFE40110.1 - 3.3 5.6 15.0 0.12 10.3 1.6 3.6 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family DIOX_N PF14226.1 EFE40111.1 - 3.6e-34 117.7 0.0 3.7e-32 111.2 0.0 2.4 2 0 0 2 2 2 2 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFE40111.1 - 5.4e-08 33.0 0.0 9.8e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.11 EFE40112.1 - 9.6e-39 133.0 67.0 1.1e-36 126.2 34.4 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.14 EFE40112.1 - 0.00018 20.1 1.2 0.00018 20.1 0.8 2.6 2 1 0 2 2 2 1 LacY proton/sugar symporter DUF2254 PF10011.4 EFE40112.1 - 0.0024 16.3 0.1 0.005 15.3 0.1 1.6 1 0 0 1 1 1 1 Predicted membrane protein (DUF2254) Sarcolipin PF05366.6 EFE40112.1 - 0.054 12.9 0.1 0.13 11.7 0.1 1.6 1 0 0 1 1 1 0 Sarcolipin DNA_primase_S PF01896.14 EFE40113.1 - 2.7e-55 186.1 0.0 5.5e-55 185.1 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit CDC27 PF09507.5 EFE40113.1 - 4.6 6.3 14.9 7.3 5.7 10.3 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MAM33 PF02330.11 EFE40114.1 - 2.5e-31 109.0 1.0 3.3e-31 108.6 0.7 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein DUF3567 PF12091.3 EFE40114.1 - 0.15 12.0 0.6 0.91 9.5 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3567) cobW PF02492.14 EFE40115.1 - 2e-47 160.9 5.8 1e-35 122.8 0.7 2.2 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 EFE40115.1 - 1.6e-21 75.7 0.1 3.8e-17 61.7 0.0 2.9 3 0 0 3 3 3 2 Cobalamin synthesis protein cobW C-terminal domain AAA_33 PF13671.1 EFE40115.1 - 0.0031 17.3 0.0 0.081 12.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EFE40115.1 - 0.0064 16.1 0.1 0.027 14.1 0.1 2.2 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 EFE40115.1 - 0.028 14.5 0.4 0.14 12.3 0.3 2.2 1 1 0 1 1 1 0 AAA domain ArgK PF03308.11 EFE40115.1 - 0.037 12.7 0.5 1.2 7.8 0.0 2.3 2 0 0 2 2 2 0 ArgK protein T2SE PF00437.15 EFE40115.1 - 0.039 12.8 0.0 0.079 11.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Arch_ATPase PF01637.13 EFE40115.1 - 0.048 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase AAA_29 PF13555.1 EFE40115.1 - 0.066 12.7 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFE40115.1 - 0.098 12.9 0.0 0.098 12.9 0.0 2.7 4 0 0 4 4 4 0 AAA domain UPF0079 PF02367.12 EFE40115.1 - 0.1 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_16 PF13191.1 EFE40115.1 - 0.12 12.3 0.7 0.32 10.9 0.5 1.9 1 1 0 1 1 1 0 AAA ATPase domain DUF2962 PF11176.3 EFE40116.1 - 1.4e-46 157.8 4.6 1.6e-46 157.7 3.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) DUF4510 PF14971.1 EFE40116.1 - 0.039 14.1 2.7 3.2 7.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4510) Fez1 PF06818.10 EFE40116.1 - 0.13 12.2 4.0 0.24 11.3 2.8 1.5 1 0 0 1 1 1 0 Fez1 XPG_I PF00867.13 EFE40117.1 - 2.9e-24 84.9 0.0 5.8e-24 83.9 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EFE40117.1 - 3.5e-24 84.9 0.0 1.4e-22 79.8 0.0 2.9 3 0 0 3 3 3 1 XPG N-terminal domain XPG_I_2 PF12813.2 EFE40117.1 - 0.0065 15.9 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing TPR_2 PF07719.12 EFE40117.1 - 0.13 12.2 0.0 0.36 10.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat BRF1 PF07741.8 EFE40118.1 - 0.054 13.7 4.7 0.063 13.4 3.2 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain SPT6_acidic PF14632.1 EFE40118.1 - 0.054 13.6 3.0 0.064 13.4 2.1 1.1 1 0 0 1 1 1 0 Acidic N-terminal SPT6 DUF3899 PF13038.1 EFE40118.1 - 0.2 11.8 0.8 0.22 11.7 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) BLVR PF06375.6 EFE40118.1 - 0.33 10.7 7.1 0.35 10.6 4.9 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Peptidase_S49_N PF08496.5 EFE40118.1 - 0.42 10.3 2.6 0.44 10.3 1.8 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Fig1 PF12351.3 EFE40119.1 - 2.8e-57 193.5 4.6 2.8e-57 193.5 3.2 1.9 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.7 EFE40119.1 - 3.3e-09 36.6 8.1 7.5e-09 35.4 5.6 1.6 1 1 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.8 EFE40119.1 - 0.0051 15.7 5.0 0.0051 15.7 3.5 1.5 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF898) FmdA_AmdA PF03069.10 EFE40119.1 - 0.052 12.2 0.0 0.061 12.0 0.0 1.1 1 0 0 1 1 1 0 Acetamidase/Formamidase family MLTD_N PF06474.7 EFE40119.1 - 0.18 11.9 7.4 0.097 12.8 2.6 2.4 2 0 0 2 2 2 0 MltD lipid attachment motif DUF202 PF02656.10 EFE40119.1 - 0.27 11.4 9.5 10 6.4 4.0 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF202) AdoMet_MTase PF07757.8 EFE40120.1 - 2e-36 124.5 0.0 6e-19 68.2 0.0 2.3 2 0 0 2 2 2 2 Predicted AdoMet-dependent methyltransferase SMC_N PF02463.14 EFE40121.1 - 8.1e-23 80.8 0.0 1.5e-22 79.9 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFE40121.1 - 9.9e-13 48.8 60.6 1.2e-11 45.3 18.3 5.6 2 2 0 2 2 2 1 AAA domain AAA_21 PF13304.1 EFE40121.1 - 2.3e-05 24.5 0.3 0.0016 18.4 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 EFE40121.1 - 0.0013 18.2 0.0 0.0026 17.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EFE40121.1 - 0.038 13.4 4.9 0.14 11.4 0.0 3.4 3 0 0 3 3 3 0 AAA domain Baculo_PEP_C PF04513.7 EFE40121.1 - 0.12 12.1 11.7 2.8 7.7 0.4 4.2 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran PF00005.22 EFE40121.1 - 0.31 11.3 0.0 0.31 11.3 0.0 4.2 4 1 0 4 4 4 0 ABC transporter AAA_13 PF13166.1 EFE40121.1 - 2.8 6.2 60.2 0.29 9.5 0.0 4.6 3 2 0 3 3 3 0 AAA domain DUF3573 PF12097.3 EFE40121.1 - 4.5 5.7 8.2 1 7.8 2.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) Reo_sigmaC PF04582.7 EFE40121.1 - 9.9 5.2 14.7 3 6.9 1.5 3.6 2 1 2 4 4 4 0 Reovirus sigma C capsid protein RGS PF00615.14 EFE40122.1 - 9.9e-06 25.6 0.1 0.00096 19.2 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF2892 PF11127.3 EFE40122.1 - 1.8 8.4 5.8 1.6 8.6 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) Lipase_3 PF01764.20 EFE40123.1 - 5.8e-16 58.3 0.0 4.7e-15 55.4 0.0 2.3 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EFE40123.1 - 0.012 15.3 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family BBS2_C PF14782.1 EFE40124.1 - 0.0069 14.9 2.4 0.0088 14.6 1.7 1.2 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal DUF3450 PF11932.3 EFE40124.1 - 0.025 13.8 6.2 0.03 13.6 4.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) L31 PF09784.4 EFE40124.1 - 0.047 13.7 0.5 0.063 13.3 0.3 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 DUF1465 PF07323.7 EFE40124.1 - 0.061 12.8 3.3 0.077 12.5 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) DUF3276 PF11680.3 EFE40124.1 - 0.25 11.1 3.1 0.32 10.7 1.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3276) DASH_Hsk3 PF08227.6 EFE40125.1 - 3.7e-20 71.8 4.1 4.9e-20 71.4 2.9 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like FA_desaturase PF00487.19 EFE40126.1 - 2.1e-24 86.3 13.9 3.4e-24 85.6 9.6 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 EFE40126.1 - 8.6e-09 35.5 0.0 1.6e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Rad51 PF08423.6 EFE40127.1 - 6.4e-22 77.6 0.0 1e-21 77.0 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 EFE40127.1 - 3.1e-10 39.7 0.0 5.2e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 EFE40127.1 - 1.9e-06 27.1 0.0 4e-06 26.1 0.0 1.4 1 1 0 1 1 1 1 KaiC DUF1254 PF06863.7 EFE40127.1 - 0.0021 17.9 0.0 0.59 9.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1254) AAA_22 PF13401.1 EFE40127.1 - 0.01 15.9 0.0 0.024 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.10 EFE40127.1 - 0.017 14.0 0.1 0.059 12.2 0.1 1.7 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain RecA PF00154.16 EFE40127.1 - 0.044 12.8 0.2 0.081 11.9 0.0 1.5 2 0 0 2 2 2 0 recA bacterial DNA recombination protein NACHT PF05729.7 EFE40127.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain MFS_1 PF07690.11 EFE40128.1 - 1.3e-30 106.2 23.8 1.3e-30 106.2 16.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFE40128.1 - 0.0011 17.3 1.5 0.0016 16.7 1.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DAO PF01266.19 EFE40129.1 - 6.6e-41 140.3 0.1 7.9e-41 140.1 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE40129.1 - 2e-05 24.5 0.5 4.6e-05 23.3 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFE40129.1 - 2.4e-05 24.4 0.0 0.081 12.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFE40129.1 - 0.0011 18.1 0.0 0.0018 17.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family K_oxygenase PF13434.1 EFE40129.1 - 0.0015 17.5 0.0 0.0035 16.3 0.0 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.19 EFE40129.1 - 0.0092 14.8 1.0 0.02 13.7 0.5 1.6 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.1 EFE40129.1 - 0.011 15.4 0.0 0.082 12.6 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 EFE40129.1 - 0.019 13.9 0.1 0.031 13.1 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein La PF05383.12 EFE40130.1 - 2.1e-16 59.4 0.0 4.4e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.17 EFE40130.1 - 4.3e-05 23.0 0.1 0.00012 21.6 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40130.1 - 9.1e-05 22.3 0.0 0.0002 21.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Plasmodium_Vir PF05795.6 EFE40130.1 - 1.8 7.6 6.1 0.26 10.4 0.3 2.0 2 0 0 2 2 2 0 Plasmodium vivax Vir protein PMSI1 PF15322.1 EFE40130.1 - 5.5 5.9 7.5 10 5.0 5.2 1.4 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Chitin_synth_2 PF03142.10 EFE40131.1 - 3.3e-23 81.8 2.0 3.3e-23 81.8 1.4 2.5 3 0 0 3 3 3 2 Chitin synthase Glyco_tranf_2_3 PF13641.1 EFE40131.1 - 9.1e-16 58.3 0.0 1.9e-15 57.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EFE40131.1 - 3.7e-15 56.1 10.1 3.7e-15 56.1 7.0 2.7 2 2 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 EFE40131.1 - 0.025 14.2 0.0 4 7.1 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 Aldolase_II PF00596.16 EFE40133.1 - 8.8e-43 146.0 0.1 1.1e-42 145.7 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Med31 PF05669.7 EFE40135.1 - 6.5e-27 93.2 0.0 6.5e-27 93.2 0.0 1.6 2 0 0 2 2 2 1 SOH1 FA_desaturase PF00487.19 EFE40135.1 - 0.006 16.0 0.1 0.012 15.0 0.0 1.5 2 0 0 2 2 2 1 Fatty acid desaturase NADH_B2 PF14813.1 EFE40135.1 - 0.092 12.4 0.1 2.9 7.6 0.0 2.5 2 0 0 2 2 2 0 NADH dehydrogenase 1 beta subcomplex subunit 2 Ribosomal_L34e PF01199.13 EFE40135.1 - 0.62 10.3 6.4 4.6 7.5 4.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L34e Pal1 PF08316.6 EFE40136.1 - 3.2e-49 166.9 1.1 3.2e-49 166.9 0.8 2.2 2 0 0 2 2 2 1 Pal1 cell morphology protein Xan_ur_permease PF00860.15 EFE40137.1 - 2.4e-14 52.6 8.5 3.2e-14 52.2 5.9 1.3 1 0 0 1 1 1 1 Permease family Sulfate_transp PF00916.15 EFE40137.1 - 2.4e-05 23.4 2.6 2.4e-05 23.4 1.8 2.1 1 1 1 2 2 2 1 Sulfate transporter family DUF973 PF06157.6 EFE40137.1 - 0.0085 15.0 0.7 0.011 14.7 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF973) MAGE PF01454.14 EFE40138.1 - 1.4e-34 119.1 0.0 1e-16 60.8 0.0 2.2 1 1 1 2 2 2 2 MAGE family Ank PF00023.25 EFE40139.1 - 6.5e-08 32.0 0.1 1.5e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 EFE40139.1 - 4.3e-06 26.7 0.0 0.11 12.7 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFE40139.1 - 8.6e-06 26.0 0.0 1.7e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EFE40139.1 - 9.6e-06 25.3 0.0 3.2e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 EFE40139.1 - 6.5e-05 23.3 0.0 0.0057 17.1 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Glyco_hydro_97 PF10566.4 EFE40139.1 - 0.029 13.4 0.0 0.036 13.1 0.0 1.1 1 0 0 1 1 1 0 Glycoside hydrolase 97 PPR PF01535.15 EFE40139.1 - 0.19 11.7 0.7 0.19 11.7 0.5 1.7 2 0 0 2 2 2 0 PPR repeat PhyH PF05721.8 EFE40140.1 - 9.7e-22 78.0 0.0 1.2e-21 77.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.7 EFE40140.1 - 0.026 13.0 0.0 0.038 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) AA_permease_2 PF13520.1 EFE40141.1 - 4.7e-34 117.6 53.0 5.9e-34 117.3 36.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE40141.1 - 3.4e-09 35.5 45.9 4.4e-09 35.1 31.8 1.1 1 0 0 1 1 1 1 Amino acid permease NmrA PF05368.8 EFE40142.1 - 1e-07 31.4 0.0 1.6e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family CUE PF02845.11 EFE40142.1 - 0.018 14.5 0.2 2.8 7.5 0.0 2.5 2 0 0 2 2 2 0 CUE domain NAD_binding_10 PF13460.1 EFE40142.1 - 0.11 12.4 0.1 0.42 10.5 0.1 1.9 1 1 0 1 1 1 0 NADH(P)-binding Aminotran_1_2 PF00155.16 EFE40143.1 - 2.4e-18 66.2 0.0 3.1e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFE40143.1 - 0.0059 15.3 0.0 0.0087 14.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFE40143.1 - 0.067 12.2 0.2 1.1 8.2 0.0 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family PhyH PF05721.8 EFE40144.1 - 7.1e-19 68.6 0.0 1.2e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AMP-binding PF00501.23 EFE40145.1 - 1e-95 320.6 0.0 1.8e-95 319.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.21 EFE40145.1 - 1.2e-88 296.8 0.2 2.2e-88 296.0 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFE40145.1 - 7e-68 229.2 0.7 3.8e-67 226.8 1.0 1.8 2 0 0 2 2 2 1 Acyl transferase domain KR PF08659.5 EFE40145.1 - 4.9e-61 205.5 0.1 7.4e-58 195.1 0.1 2.9 2 0 0 2 2 2 2 KR domain adh_short PF00106.20 EFE40145.1 - 5.8e-55 185.7 0.1 7.8e-51 172.2 0.1 3.1 2 0 0 2 2 2 2 short chain dehydrogenase NAD_binding_4 PF07993.7 EFE40145.1 - 7.4e-48 162.6 0.0 2.6e-46 157.5 0.0 2.6 2 1 0 2 2 2 1 Male sterility protein Ketoacyl-synt_C PF02801.17 EFE40145.1 - 1.7e-40 137.5 0.5 6e-40 135.8 0.4 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFE40145.1 - 1.3e-22 79.8 0.0 2.2e-12 47.0 0.0 3.1 2 0 0 2 2 2 2 Phosphopantetheine attachment site Epimerase PF01370.16 EFE40145.1 - 9.1e-14 51.4 0.0 2.3e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.1 EFE40145.1 - 2.4e-12 47.6 0.0 9.8e-12 45.6 0.0 2.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.14 EFE40145.1 - 4.7e-07 28.7 0.0 0.0069 15.1 0.0 2.4 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EFE40145.1 - 1.4e-06 27.4 0.0 0.018 13.9 0.0 2.4 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 EFE40145.1 - 1.8e-05 24.8 0.7 0.0055 16.7 0.0 3.1 3 0 0 3 3 3 1 NADH(P)-binding Thiolase_N PF00108.18 EFE40145.1 - 0.00018 20.5 0.3 0.0025 16.8 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain NmrA PF05368.8 EFE40145.1 - 0.0034 16.6 0.1 0.019 14.2 0.0 2.3 2 0 0 2 2 2 1 NmrA-like family SLS PF14611.1 EFE40145.1 - 0.48 9.8 0.1 0.98 8.8 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Peptidase_S24 PF00717.18 EFE40146.1 - 1.3e-06 27.9 0.3 6.8e-06 25.6 0.2 2.1 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 EFE40146.1 - 0.026 14.0 0.0 1.1 8.7 0.0 2.3 1 1 1 2 2 2 0 Signal peptidase, peptidase S26 Ank_2 PF12796.2 EFE40147.1 - 3.7e-11 43.1 0.1 3.9e-10 39.9 0.0 2.3 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFE40147.1 - 3.7e-09 35.9 0.0 4.8e-05 22.9 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 EFE40147.1 - 2.5e-07 30.2 0.2 0.00066 19.6 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 EFE40147.1 - 5.5e-06 26.4 1.0 2.6e-05 24.3 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE40147.1 - 2.7e-05 24.5 0.1 9e-05 22.8 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Macro PF01661.16 EFE40148.1 - 2.1e-33 114.6 0.0 4e-33 113.8 0.0 1.5 1 0 0 1 1 1 1 Macro domain MSP1_C PF07462.6 EFE40148.1 - 0.084 11.2 1.1 0.11 10.8 0.8 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Fungal_trans PF04082.13 EFE40149.1 - 3.5e-22 78.5 0.1 7e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain BDV_P10 PF06515.6 EFE40149.1 - 0.0047 16.7 1.2 0.021 14.6 0.8 2.1 1 0 0 1 1 1 1 Borna disease virus P10 protein Na_Ca_ex PF01699.19 EFE40150.1 - 4.2e-41 139.8 31.4 2.4e-22 79.0 8.0 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3951 PF13131.1 EFE40150.1 - 0.073 12.8 2.1 2.9 7.7 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) GHMP_kinases_N PF00288.21 EFE40151.1 - 8.7e-15 54.5 1.1 1.9e-14 53.4 0.8 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EFE40151.1 - 6.4e-07 29.4 0.0 1.4e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal MCM PF00493.18 EFE40152.1 - 5.2e-132 439.6 0.1 8e-132 439.0 0.1 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EFE40152.1 - 5e-17 62.5 0.0 5e-17 62.5 0.0 2.4 2 1 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 EFE40152.1 - 7e-05 22.0 0.0 0.00038 19.6 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFE40152.1 - 0.0044 16.7 0.0 0.014 15.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EFE40152.1 - 0.0085 15.7 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFE40152.1 - 0.014 14.8 0.0 0.036 13.5 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Voltage_CLC PF00654.15 EFE40153.1 - 7.2e-89 298.2 26.9 7.2e-89 298.2 18.6 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 EFE40153.1 - 7.7e-12 44.8 0.0 0.00013 21.6 0.0 2.4 2 0 0 2 2 2 2 CBS domain VPEP PF07589.6 EFE40153.1 - 0.1 12.5 1.3 0.96 9.4 0.9 2.8 1 0 0 1 1 1 0 PEP-CTERM motif UCR_TM PF02921.9 EFE40155.1 - 1.2e-17 63.8 2.7 3e-17 62.5 1.9 1.7 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.21 EFE40155.1 - 2.9e-16 58.8 0.0 4.9e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain She9_MDM33 PF05546.6 EFE40156.1 - 5.2e-93 310.3 9.4 7.4e-93 309.8 6.5 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family PsbH PF00737.15 EFE40156.1 - 0.0084 15.6 1.0 0.017 14.6 0.7 1.4 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein DUF1395 PF07160.7 EFE40156.1 - 0.98 8.8 6.3 0.11 11.9 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1395) DUF1110 PF06533.7 EFE40156.1 - 5.3 6.8 9.5 1.2 8.8 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1110) Aminotran_1_2 PF00155.16 EFE40157.1 - 6.1e-29 101.0 0.0 2.2e-14 53.2 0.0 2.2 2 1 0 2 2 2 2 Aminotransferase class I and II RabGAP-TBC PF00566.13 EFE40157.1 - 0.15 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Fungal_trans PF04082.13 EFE40158.1 - 1.3e-14 53.7 2.3 1.3e-14 53.7 1.6 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain PNPOx_C PF10590.4 EFE40159.1 - 4.7e-22 77.2 3.1 3.5e-21 74.4 1.4 2.5 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxidase PF01243.15 EFE40159.1 - 7.8e-11 41.8 0.0 5.3e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.2 EFE40159.1 - 0.0031 17.7 0.1 0.029 14.6 0.1 2.2 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Vpu PF00558.14 EFE40159.1 - 0.062 12.8 0.3 2.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Vpu protein ILVD_EDD PF00920.16 EFE40160.1 - 4.1e-203 675.5 2.9 4.8e-203 675.3 2.0 1.0 1 0 0 1 1 1 1 Dehydratase family InvH PF04741.7 EFE40160.1 - 0.068 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 InvH outer membrane lipoprotein Abhydrolase_6 PF12697.2 EFE40161.1 - 6.9e-21 75.1 0.2 1.5e-20 74.0 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE40161.1 - 2.7e-11 43.4 0.0 2.8e-10 40.0 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE40161.1 - 6.6e-09 35.6 0.0 4.3e-08 32.9 0.0 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold DSPc PF00782.15 EFE40161.1 - 3.6e-08 33.0 0.0 1.4e-07 31.1 0.0 1.9 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF2305 PF10230.4 EFE40161.1 - 7.1e-05 22.3 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) PGAP1 PF07819.8 EFE40161.1 - 0.00024 20.7 0.2 0.00057 19.5 0.1 1.6 1 1 0 1 1 1 1 PGAP1-like protein Ser_hydrolase PF06821.8 EFE40161.1 - 0.00024 20.7 0.1 0.00044 19.9 0.1 1.3 1 0 0 1 1 1 1 Serine hydrolase Y_phosphatase PF00102.22 EFE40161.1 - 0.00059 19.2 0.0 0.0027 17.1 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EFE40161.1 - 0.0017 18.4 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate LCAT PF02450.10 EFE40161.1 - 0.0075 15.2 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Chlorophyllase2 PF12740.2 EFE40161.1 - 0.085 11.7 0.1 0.19 10.5 0.1 1.4 1 1 0 1 1 1 0 Chlorophyllase enzyme Lipase_3 PF01764.20 EFE40161.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.7 EFE40161.1 - 0.16 11.2 0.3 0.29 10.4 0.2 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PAF-AH_p_II PF03403.8 EFE40161.1 - 0.31 9.2 0.7 0.77 7.9 0.1 1.7 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Ribosomal_S19e PF01090.14 EFE40162.1 - 5.4e-46 155.5 0.8 6.4e-46 155.2 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Aldo_ket_red PF00248.16 EFE40164.1 - 4.1e-42 143.9 0.0 5.8e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family APH PF01636.18 EFE40165.1 - 1.8e-06 27.8 0.2 3.8e-06 26.8 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFE40165.1 - 0.027 13.6 0.0 0.036 13.2 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase eRF1_1 PF03463.10 EFE40166.1 - 1.8e-30 105.2 0.0 4.8e-30 103.8 0.0 1.7 1 1 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.10 EFE40166.1 - 1e-17 64.4 0.0 1.7e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.10 EFE40166.1 - 3.3e-16 59.8 0.0 5.7e-15 55.8 0.0 2.2 1 1 0 1 1 1 1 eRF1 domain 2 Myb_DNA-bind_4 PF13837.1 EFE40167.1 - 0.00075 19.5 2.6 0.0038 17.3 0.1 2.4 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Rtf2 PF04641.7 EFE40169.1 - 0.92 8.6 13.0 1.3 8.1 9.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger SAGA-Tad1 PF12767.2 EFE40169.1 - 2 8.0 10.0 2.5 7.7 6.9 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit CPSF100_C PF13299.1 EFE40169.1 - 3.1 7.9 10.9 12 6.0 0.1 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Ribosomal_L3 PF00297.17 EFE40170.1 - 6.2e-117 389.6 6.6 8.1e-117 389.2 4.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 SKN1 PF03935.10 EFE40171.1 - 2.5e-213 708.8 0.0 3.4e-213 708.3 0.0 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) BCDHK_Adom3 PF10436.4 EFE40172.1 - 5.6e-49 165.8 0.0 3.8e-46 156.6 0.0 2.2 1 1 1 2 2 2 2 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EFE40172.1 - 2.8e-14 52.7 0.0 2.1e-13 49.9 0.0 2.4 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EFE40172.1 - 0.0032 17.1 0.0 0.006 16.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Crust_neurohorm PF01147.12 EFE40172.1 - 0.098 11.9 0.1 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Activator_LAG-3 PF11498.3 EFE40172.1 - 0.15 10.8 0.1 0.23 10.1 0.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Ank_2 PF12796.2 EFE40174.1 - 8.2e-31 106.2 1.2 2.3e-13 50.2 0.0 4.3 2 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFE40174.1 - 2.7e-25 86.8 11.0 1.7e-05 24.3 0.0 7.4 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.1 EFE40174.1 - 6.8e-25 84.6 3.8 8.9e-05 22.3 0.0 8.3 7 1 1 8 8 8 4 Ankyrin repeat Ank_4 PF13637.1 EFE40174.1 - 9.9e-25 86.4 4.3 1.4e-11 44.5 0.1 6.1 5 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE40174.1 - 1.6e-24 85.3 0.8 2.5e-06 27.5 0.0 5.8 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Nucleoporin_FG PF13634.1 EFE40174.1 - 9 6.5 17.4 18 5.6 12.0 1.4 1 1 0 1 1 1 0 Nucleoporin FG repeat region Exo70 PF03081.10 EFE40176.1 - 1.5e-75 254.3 0.0 2.7e-75 253.4 0.0 1.4 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Laminin_II PF06009.7 EFE40176.1 - 0.25 11.1 2.3 2.6 7.7 0.2 2.7 2 0 0 2 2 2 0 Laminin Domain II PLA2_B PF01735.13 EFE40177.1 - 3e-27 94.9 0.0 4.2e-27 94.4 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain PPR_3 PF13812.1 EFE40178.1 - 3.3e-23 79.9 4.3 0.012 15.8 0.0 9.6 10 0 0 10 10 10 5 Pentatricopeptide repeat domain PPR_2 PF13041.1 EFE40178.1 - 1.9e-19 69.3 0.1 0.02 14.8 0.0 8.4 4 4 5 9 9 9 5 PPR repeat family PPR PF01535.15 EFE40178.1 - 1e-13 50.2 5.8 0.027 14.4 0.0 8.0 9 0 0 9 9 9 2 PPR repeat DUF3312 PF11768.3 EFE40178.1 - 0.0086 14.3 0.0 0.015 13.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3312) DUF1018 PF06252.7 EFE40178.1 - 0.016 15.7 0.2 7.4 7.1 0.1 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1018) Dak1_2 PF13684.1 EFE40178.1 - 0.016 14.1 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family TPR_9 PF13371.1 EFE40178.1 - 0.049 13.4 0.1 7.4 6.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR_1 PF12854.2 EFE40178.1 - 0.64 9.5 2.9 10 5.6 0.0 3.3 4 0 0 4 4 4 0 PPR repeat DSPc PF00782.15 EFE40179.1 - 2.1e-11 43.5 0.0 3.4e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFE40179.1 - 4e-06 26.3 0.0 1.5e-05 24.5 0.0 1.8 1 1 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 EFE40179.1 - 0.015 15.5 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.7 EFE40179.1 - 0.057 12.8 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 EFE40179.1 - 0.071 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate His_Phos_1 PF00300.17 EFE40180.1 - 1.3e-18 67.6 0.0 1.9e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SNF2_assoc PF08455.5 EFE40181.1 - 0.12 10.9 0.0 0.15 10.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial SNF2 helicase associated Phage-tail_3 PF13550.1 EFE40181.1 - 0.19 11.4 2.3 0.44 10.3 0.4 2.2 3 0 0 3 3 3 0 Putative phage tail protein F-box-like PF12937.2 EFE40182.1 - 5.8e-05 22.7 0.1 0.00014 21.4 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE40182.1 - 0.023 14.3 0.0 0.07 12.8 0.0 1.9 1 0 0 1 1 1 0 F-box domain MFS_1 PF07690.11 EFE40183.1 - 6.4e-07 28.3 18.3 7e-07 28.2 12.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Cytochrom_B_N PF00033.14 EFE40183.1 - 0.092 12.0 3.4 0.27 10.5 2.4 1.8 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB MFS_1 PF07690.11 EFE40184.1 - 5.1e-14 51.7 20.9 6.7e-14 51.3 14.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily RRM_1 PF00076.17 EFE40186.1 - 1.9e-80 264.4 5.9 1.9e-22 78.6 0.2 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40186.1 - 3.3e-55 183.9 0.4 2.6e-15 56.1 0.0 5.3 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE40186.1 - 2.2e-41 139.5 0.3 8.2e-11 41.5 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 EFE40186.1 - 4.5e-28 96.7 0.9 1.7e-27 94.8 0.1 2.4 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain Nup35_RRM_2 PF14605.1 EFE40186.1 - 5e-05 22.9 0.1 9.7 6.0 0.0 5.0 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 EFE40186.1 - 7.4e-05 22.4 1.9 2.8 7.7 0.0 3.7 3 0 0 3 3 3 2 Limkain b1 CbiG_mid PF11761.3 EFE40186.1 - 0.00081 19.5 0.0 3.6 7.9 0.0 3.5 3 0 0 3 3 3 2 Cobalamin biosynthesis central region OB_RNB PF08206.6 EFE40186.1 - 0.089 12.3 2.0 12 5.5 0.0 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain FAM176 PF14851.1 EFE40186.1 - 4.6 6.9 6.8 13 5.4 4.7 1.7 1 0 0 1 1 1 0 FAM176 family Fe-ADH PF00465.14 EFE40187.1 - 8.9e-24 83.7 0.1 1.5e-21 76.4 0.0 1.9 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase DAO PF01266.19 EFE40188.1 - 8e-31 107.2 0.0 8.9e-31 107.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Vps52 PF04129.7 EFE40189.1 - 1.4e-119 399.9 2.9 1.8e-119 399.5 2.0 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.4 EFE40189.1 - 5.8e-07 28.0 1.6 8.1e-07 27.5 1.1 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Nup54 PF13874.1 EFE40189.1 - 0.044 13.4 0.0 0.13 11.9 0.0 1.8 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 eIF-5a PF01287.15 EFE40190.1 - 8.5e-25 86.4 1.0 1.3e-24 85.9 0.7 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 EFE40190.1 - 2.8e-05 23.6 0.9 6.6e-05 22.4 0.6 1.6 1 0 0 1 1 1 1 KOW motif EFP_N PF08207.7 EFE40190.1 - 0.0031 17.3 0.5 0.017 15.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain RRN7 PF11781.3 EFE40191.1 - 1.8e-06 27.2 5.2 4e-06 26.2 3.6 1.6 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 Ribosomal_L40e PF01020.12 EFE40192.1 - 1.8e-30 104.2 10.6 3e-30 103.5 7.4 1.3 1 0 0 1 1 1 1 Ribosomal L40e family ubiquitin PF00240.18 EFE40192.1 - 2.9e-14 52.1 0.0 1e-13 50.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.3 EFE40192.1 - 0.00052 19.6 0.0 0.00086 18.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Yip1 PF04893.12 EFE40193.1 - 1.4e-15 57.2 16.7 2.7e-15 56.3 11.6 1.5 1 1 0 1 1 1 1 Yip1 domain RabGAP-TBC PF00566.13 EFE40194.1 - 3.1e-23 82.3 0.3 6.8e-23 81.2 0.3 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain MMS1_N PF10433.4 EFE40195.1 - 2.5e-08 32.4 0.0 3.5e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term MMS1_N PF10433.4 EFE40196.1 - 1.4e-104 350.0 0.0 4.8e-104 348.2 0.0 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 EFE40196.1 - 7.8e-06 25.2 0.0 0.00018 20.7 0.0 2.1 2 0 0 2 2 2 2 CPSF A subunit region GTP_EFTU PF00009.22 EFE40197.1 - 9.8e-33 113.1 0.0 6.6e-32 110.4 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EFE40197.1 - 6.1e-20 71.1 0.1 1.7e-19 69.7 0.1 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EFE40197.1 - 1.1e-11 44.6 0.7 1.2e-09 38.0 0.0 3.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFE40197.1 - 2.7e-06 27.3 0.0 1.1e-05 25.3 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE40197.1 - 0.0012 19.3 0.0 0.0072 16.8 0.0 2.4 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU_D4 PF14578.1 EFE40197.1 - 0.0023 17.5 0.0 0.0084 15.7 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 ATP_bind_1 PF03029.12 EFE40197.1 - 0.0051 16.3 0.0 0.015 14.8 0.0 1.9 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Rhodanese PF00581.15 EFE40198.1 - 5.4e-12 46.0 0.0 1.1e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain p450 PF00067.17 EFE40199.1 - 6.1e-54 183.2 0.0 8.9e-54 182.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF3439 PF11921.3 EFE40199.1 - 0.0065 16.2 1.1 0.014 15.0 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) ADH_zinc_N_2 PF13602.1 EFE40200.1 - 2.3e-20 73.7 0.0 4.2e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFE40200.1 - 2.4e-15 56.2 0.3 4.1e-15 55.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.1 EFE40200.1 - 0.0017 18.3 0.1 0.0032 17.5 0.1 1.4 1 0 0 1 1 1 1 NADH(P)-binding ADH_N PF08240.7 EFE40200.1 - 0.0048 16.6 0.0 0.0097 15.6 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PGM_PMM_II PF02879.11 EFE40200.1 - 0.047 14.0 0.0 0.18 12.1 0.0 2.0 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Glyco_hydro_15 PF00723.16 EFE40201.1 - 1e-91 307.7 0.1 1.3e-91 307.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.14 EFE40201.1 - 1.4e-28 98.3 0.0 3.2e-28 97.1 0.0 1.7 1 0 0 1 1 1 1 Starch binding domain Antitoxin-MazE PF04014.13 EFE40201.1 - 0.061 13.0 0.0 1.9 8.3 0.0 2.4 2 0 0 2 2 2 0 Antidote-toxin recognition MazE Aha1_N PF09229.6 EFE40202.1 - 4.4e-38 130.1 0.2 7.6e-38 129.4 0.2 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 EFE40202.1 - 2e-16 60.1 0.1 4.2e-16 59.1 0.1 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Dicty_REP PF05086.7 EFE40202.1 - 2.1 5.9 4.4 2.8 5.5 3.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.12 EFE40202.1 - 2.8 7.7 21.2 4.7 6.9 14.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein FBPase PF00316.15 EFE40205.1 - 1.9e-120 401.5 0.0 2.2e-120 401.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase DUF912 PF06024.7 EFE40206.1 - 0.11 12.5 0.5 0.21 11.6 0.4 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Cortexin PF11057.3 EFE40206.1 - 0.15 11.6 0.3 0.31 10.6 0.2 1.5 1 0 0 1 1 1 0 Cortexin of kidney Fungal_trans_2 PF11951.3 EFE40207.1 - 7.5e-31 107.0 0.5 9.5e-31 106.7 0.4 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cellulase-like PF12876.2 EFE40207.1 - 0.088 13.2 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Sugar-binding cellulase-like E1-E2_ATPase PF00122.15 EFE40208.1 - 2.8e-64 216.3 5.4 5.6e-64 215.3 3.2 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE40208.1 - 2.6e-27 95.5 6.1 2.6e-27 95.5 4.3 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE40208.1 - 3.9e-19 69.9 0.0 1.5e-18 67.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE40208.1 - 1.5e-17 63.2 0.0 4.6e-17 61.7 0.0 1.8 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 EFE40208.1 - 5.2e-16 57.8 0.0 1.3e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 EFE40208.1 - 4.2e-05 23.7 0.0 8.5e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE40208.1 - 0.0023 17.5 0.7 0.026 14.1 1.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HlyIII PF03006.15 EFE40209.1 - 4.3e-27 94.9 16.0 1.7e-25 89.7 11.1 2.0 1 1 0 1 1 1 1 Haemolysin-III related DUF3325 PF11804.3 EFE40209.1 - 0.18 11.7 3.0 1.3 9.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) Sugar_tr PF00083.19 EFE40210.1 - 1.5e-74 251.2 21.6 1.9e-74 250.9 15.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE40210.1 - 1.1e-19 70.4 35.0 9.4e-13 47.5 5.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily V_ATPase_I PF01496.14 EFE40211.1 - 8.5e-289 959.6 0.7 9.8e-289 959.4 0.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1515 PF07439.6 EFE40211.1 - 0.0013 18.5 0.2 0.004 16.9 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1515) CheZ PF04344.8 EFE40211.1 - 0.2 11.2 4.4 0.68 9.5 0.0 2.5 3 0 0 3 3 3 0 Chemotaxis phosphatase, CheZ DUF869 PF05911.6 EFE40211.1 - 0.29 9.3 3.7 0.4 8.8 0.7 1.9 2 0 0 2 2 2 0 Plant protein of unknown function (DUF869) IncA PF04156.9 EFE40211.1 - 0.31 10.6 4.6 0.54 9.8 1.6 2.2 2 0 0 2 2 2 0 IncA protein Filament PF00038.16 EFE40211.1 - 0.46 9.8 9.8 2.3 7.5 0.1 2.5 2 1 0 2 2 2 0 Intermediate filament protein DUF3552 PF12072.3 EFE40211.1 - 0.47 9.6 4.9 5.6 6.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) YlqD PF11068.3 EFE40211.1 - 1.2 9.2 5.3 1.4 9.0 1.1 2.4 2 1 1 3 3 3 0 YlqD protein DUF342 PF03961.8 EFE40211.1 - 2.5 6.4 5.0 0.72 8.2 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF342) CCDC-167 PF15188.1 EFE40211.1 - 4.4 7.3 6.1 7.9 6.5 2.3 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DivIC PF04977.10 EFE40211.1 - 4.5 6.8 6.0 1.1 8.7 0.2 2.9 4 0 0 4 4 4 0 Septum formation initiator MOSC PF03473.12 EFE40212.1 - 0.0025 17.2 0.2 0.0067 15.8 0.1 1.7 1 1 0 1 1 1 1 MOSC domain DUF3437 PF11919.3 EFE40213.1 - 2e-30 104.3 0.0 6.4e-30 102.7 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) HEAT PF02985.17 EFE40213.1 - 0.006 16.5 0.2 2.7 8.3 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 EFE40213.1 - 0.017 15.4 0.0 7.4 6.9 0.0 3.9 3 0 0 3 3 3 0 HEAT repeats Mannosyl_trans2 PF04188.8 EFE40214.1 - 3.3e-38 131.7 4.4 3.8e-38 131.5 3.1 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V)) PMT_2 PF13231.1 EFE40214.1 - 6.2e-05 22.9 4.2 0.00014 21.8 2.9 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DBD_Tnp_Hermes PF10683.4 EFE40215.1 - 0.058 12.8 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain EZH2_WD-Binding PF11616.3 EFE40216.1 - 0.0013 18.5 0.3 0.0034 17.2 0.2 1.6 1 0 0 1 1 1 1 WD repeat binding protein EZH2 Pro_CA PF00484.14 EFE40217.1 - 5e-43 146.7 0.1 6.8e-43 146.3 0.1 1.2 1 0 0 1 1 1 1 Carbonic anhydrase MOZ_SAS PF01853.13 EFE40219.1 - 1.9e-79 265.2 0.0 2.4e-78 261.7 0.0 2.1 2 0 0 2 2 2 1 MOZ/SAS family zf-Sec23_Sec24 PF04810.10 EFE40219.1 - 0.44 10.1 4.2 0.21 11.1 0.4 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Acetyltransf_2 PF00797.12 EFE40220.1 - 4.2e-32 111.6 0.0 7.2e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase Thiolase_N PF00108.18 EFE40221.1 - 1e-77 260.7 1.4 1e-77 260.7 0.9 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFE40221.1 - 1.1e-43 147.5 0.2 2e-43 146.7 0.1 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EFE40221.1 - 0.018 14.4 0.4 0.093 12.1 0.2 2.2 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain GFO_IDH_MocA PF01408.17 EFE40222.1 - 4.1e-14 53.1 0.4 1.1e-13 51.7 0.2 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Drf_GBD PF06371.8 EFE40223.1 - 1.5e-19 70.1 4.4 8.8e-18 64.3 3.1 2.4 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain CRM1_C PF08767.6 EFE40223.1 - 0.05 12.5 0.1 0.078 11.8 0.1 1.2 1 0 0 1 1 1 0 CRM1 C terminal Snf7 PF03357.16 EFE40224.1 - 1.1e-39 135.6 15.1 1.4e-39 135.2 10.5 1.1 1 0 0 1 1 1 1 Snf7 DUF3584 PF12128.3 EFE40224.1 - 6.7e-05 20.4 4.8 7.3e-05 20.3 3.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF4201 PF13870.1 EFE40224.1 - 0.00066 19.1 4.2 0.00066 19.1 2.9 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) MscS_porin PF12795.2 EFE40224.1 - 0.0041 16.4 7.5 0.2 10.9 3.2 2.2 1 1 1 2 2 2 2 Mechanosensitive ion channel porin domain Mod_r PF07200.8 EFE40224.1 - 0.013 15.4 3.2 0.013 15.4 2.2 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CENP-F_leu_zip PF10473.4 EFE40224.1 - 0.031 14.1 6.3 0.16 11.8 3.2 2.4 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NPV_P10 PF05531.7 EFE40224.1 - 0.035 14.3 6.2 0.47 10.7 1.3 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein YlqD PF11068.3 EFE40224.1 - 0.083 12.9 10.4 1.2 9.2 0.5 2.2 1 1 1 2 2 2 0 YlqD protein Mnd1 PF03962.10 EFE40224.1 - 0.14 11.8 8.9 0.43 10.2 6.2 1.8 1 1 0 1 1 1 0 Mnd1 family IncA PF04156.9 EFE40224.1 - 0.18 11.3 4.1 13 5.3 2.8 2.2 1 1 0 1 1 1 0 IncA protein DUF4140 PF13600.1 EFE40224.1 - 0.19 12.1 3.3 1.7 9.1 0.0 3.0 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Atg14 PF10186.4 EFE40224.1 - 0.37 9.6 7.5 0.53 9.1 5.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 EFE40224.1 - 0.43 8.9 6.1 1.3 7.3 3.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DUF4337 PF14235.1 EFE40224.1 - 0.82 9.4 5.4 0.44 10.3 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) BLOC1_2 PF10046.4 EFE40224.1 - 2.3 8.3 7.4 6 7.0 1.0 2.8 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Uso1_p115_C PF04871.8 EFE40224.1 - 3.6 7.5 10.7 5.1 7.0 5.1 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region OmpH PF03938.9 EFE40224.1 - 10 6.0 15.0 4.7 7.1 4.1 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) SAPS PF04499.10 EFE40225.1 - 6.3e-171 569.1 4.8 6.3e-171 569.1 3.4 2.1 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein Cauli_DNA-bind PF03310.8 EFE40225.1 - 0.036 13.9 0.4 0.13 12.0 0.3 2.0 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein Complex1_51K PF01512.12 EFE40228.1 - 1.1e-47 161.5 0.0 1.7e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 EFE40228.1 - 5.9e-18 63.7 1.7 5.9e-18 63.7 1.1 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 EFE40228.1 - 3.5e-09 36.4 0.0 8.4e-09 35.1 0.0 1.7 1 0 0 1 1 1 1 SLBB domain TSA PF03249.8 EFE40228.1 - 0.88 8.0 3.6 1.5 7.3 2.5 1.2 1 0 0 1 1 1 0 Type specific antigen Nup96 PF12110.3 EFE40229.1 - 5.5e-87 291.5 0.0 8.4e-87 290.9 0.0 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.9 EFE40229.1 - 3.7e-49 166.1 0.0 6.8e-49 165.3 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 EFE40229.1 - 5.3e-15 55.6 213.5 3.2e-09 37.0 35.9 9.3 4 2 5 9 9 9 4 Nucleoporin FG repeat region F-box-like PF12937.2 EFE40230.1 - 0.0014 18.2 0.2 0.0044 16.7 0.2 1.9 1 0 0 1 1 1 1 F-box-like zf-C3Hc3H PF13891.1 EFE40230.1 - 1.4 9.0 4.8 0.6 10.2 0.4 2.2 1 1 1 2 2 2 0 Potential DNA-binding domain AMP-binding PF00501.23 EFE40231.1 - 1.3e-92 310.4 0.0 1.7e-92 310.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE40231.1 - 1.1e-19 71.1 2.0 1.7e-17 64.1 0.7 2.8 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain GET2 PF08690.5 EFE40232.1 - 0.00024 20.4 0.0 0.00039 19.7 0.0 1.3 1 0 0 1 1 1 1 GET complex subunit GET2 C2 PF00168.25 EFE40233.1 - 4.9e-22 77.5 0.0 1.6e-14 53.5 0.0 2.5 2 0 0 2 2 2 2 C2 domain CDC45 PF02724.9 EFE40234.1 - 0.69 7.8 3.1 0.96 7.4 2.2 1.2 1 0 0 1 1 1 0 CDC45-like protein CNH PF00780.17 EFE40236.1 - 2.7e-69 233.6 0.0 4.1e-69 233.0 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.15 EFE40236.1 - 7.6e-32 110.6 1.5 1.7e-31 109.4 1.0 1.6 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.1 EFE40236.1 - 6.9e-15 55.1 0.0 3.5e-14 52.8 0.0 2.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 EFE40236.1 - 0.018 15.2 0.0 0.068 13.3 0.0 2.1 1 1 0 1 1 1 0 PH domain RabGAP-TBC PF00566.13 EFE40237.1 - 2e-46 158.2 0.0 3.3e-46 157.4 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.1 EFE40237.1 - 3.3e-06 26.5 3.0 0.011 15.5 0.2 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 EFE40237.1 - 1.8e-05 23.7 0.3 0.19 11.0 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 EFE40237.1 - 6.1e-05 23.0 0.6 0.00028 20.9 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair GRAM PF02893.15 EFE40237.1 - 0.11 11.9 0.0 0.29 10.6 0.0 1.8 1 1 0 1 1 1 0 GRAM domain Sigma70_ner PF04546.8 EFE40237.1 - 1.4 8.4 14.8 4.2 6.9 4.1 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region CRPA PF05745.6 EFE40238.1 - 0.088 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) TPR_MLP1_2 PF07926.7 EFE40239.1 - 0.00027 20.6 8.8 0.00027 20.6 6.1 3.3 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein TBPIP PF07106.8 EFE40239.1 - 0.0024 17.4 2.5 0.0024 17.4 1.8 2.6 1 1 1 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Atg14 PF10186.4 EFE40239.1 - 0.0035 16.3 8.9 0.0035 16.3 6.2 2.3 2 1 1 3 3 3 1 UV radiation resistance protein and autophagy-related subunit 14 Armet PF10208.4 EFE40239.1 - 0.036 13.7 0.2 0.073 12.7 0.2 1.4 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding XkdW PF09636.5 EFE40239.1 - 0.27 11.1 3.6 0.98 9.3 0.1 3.2 3 0 0 3 3 3 0 XkdW protein HALZ PF02183.13 EFE40239.1 - 0.36 10.5 6.8 13 5.5 0.2 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper THOC7 PF05615.8 EFE40239.1 - 0.41 10.9 13.7 1.5 9.0 2.6 2.7 1 1 1 2 2 2 0 Tho complex subunit 7 Reo_sigmaC PF04582.7 EFE40239.1 - 0.88 8.6 13.0 0.034 13.3 3.3 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 EFE40239.1 - 0.98 7.7 12.0 2.8 6.2 8.3 1.8 1 1 0 1 1 1 0 AAA domain adh_short_C2 PF13561.1 EFE40241.1 - 8.3e-21 74.8 0.5 1.3e-20 74.2 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFE40241.1 - 6.7e-18 65.1 1.7 1.3e-17 64.2 1.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE40241.1 - 8e-06 25.6 1.0 2.8e-05 23.8 0.7 1.9 1 1 0 1 1 1 1 KR domain DUF566 PF04484.7 EFE40242.1 - 0.063 12.7 1.4 0.087 12.3 1.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) DUF1772 PF08592.6 EFE40242.1 - 0.097 12.3 0.4 2.6 7.7 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF1435 PF07256.7 EFE40242.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1435) SAP PF02037.22 EFE40243.1 - 6.2e-09 35.1 0.1 1.2e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 SAP domain JAB PF01398.16 EFE40244.1 - 1.4e-09 37.7 0.7 2.4e-09 36.9 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 EFE40244.1 - 0.011 15.8 0.6 0.22 11.6 0.1 2.9 2 1 0 2 2 2 0 Maintenance of mitochondrial structure and function Proteasom_PSMB PF10508.4 EFE40245.1 - 0.0027 16.0 0.2 0.29 9.3 0.0 2.3 2 0 0 2 2 2 2 Proteasome non-ATPase 26S subunit RNA_pol_3_Rpc31 PF11705.3 EFE40246.1 - 2.9e-17 63.4 27.1 4.2e-17 62.8 18.8 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 APH PF01636.18 EFE40247.1 - 1.1e-06 28.5 0.0 2.6e-06 27.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family GLE1 PF07817.8 EFE40247.1 - 0.083 11.8 0.0 0.18 10.7 0.0 1.4 2 0 0 2 2 2 0 GLE1-like protein FAD_binding_1 PF00667.15 EFE40248.1 - 3e-33 115.0 0.0 4.4e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 EFE40248.1 - 2.5e-14 53.7 0.0 4e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFE40248.1 - 0.085 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain ETF PF01012.16 EFE40249.1 - 8.1e-20 71.1 0.0 1.1e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain DUF500 PF04366.7 EFE40250.1 - 2.3e-43 146.6 0.0 3.6e-43 145.9 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF500) PARP PF00644.15 EFE40251.1 - 1.1e-57 194.7 14.8 1.1e-55 188.2 0.0 4.4 2 2 3 5 5 5 2 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 EFE40251.1 - 4.2e-41 139.7 0.2 7.4e-41 138.9 0.1 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 EFE40251.1 - 3.7e-21 74.8 0.2 3.7e-21 74.8 0.1 2.7 3 0 0 3 3 3 1 WGR domain BRCT PF00533.21 EFE40251.1 - 1.9e-11 43.9 0.0 2.8e-10 40.1 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EFE40251.1 - 1.6e-07 31.0 0.2 4.4e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 twin BRCT domain Acetyltransf_3 PF13302.1 EFE40252.1 - 7.2e-09 35.9 0.0 9.7e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE40252.1 - 4.3e-05 23.4 0.0 0.00016 21.6 0.0 1.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 EFE40252.1 - 0.1 12.5 0.0 0.38 10.6 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_S10 PF00450.17 EFE40253.1 - 7.5e-84 282.2 4.7 2.7e-83 280.4 3.3 1.7 1 1 0 1 1 1 1 Serine carboxypeptidase Pkinase_Tyr PF07714.12 EFE40254.1 - 8.4e-23 80.7 0.0 1.7e-22 79.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 EFE40254.1 - 8.8e-23 80.7 0.0 1.4e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 EFE40254.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 EFE40254.1 - 0.041 12.8 0.0 0.19 10.6 0.0 1.9 1 1 0 1 1 1 0 Kinase-like Rotamase PF00639.16 EFE40255.1 - 0.0054 17.4 4.2 0.0054 17.4 2.9 2.1 1 1 1 2 2 2 1 PPIC-type PPIASE domain SR-25 PF10500.4 EFE40255.1 - 0.041 13.3 7.6 0.054 12.9 5.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein His_Phos_1 PF00300.17 EFE40255.1 - 0.14 12.2 0.9 0.2 11.7 0.6 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) AD PF09793.4 EFE40255.1 - 0.18 11.7 4.3 0.076 12.8 0.9 1.9 2 0 0 2 2 2 0 Anticodon-binding domain Borrelia_P83 PF05262.6 EFE40255.1 - 0.23 9.7 13.9 0.27 9.4 9.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein FLO_LFY PF01698.11 EFE40255.1 - 0.27 10.0 5.1 0.35 9.6 3.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein VIT1 PF01988.14 EFE40255.1 - 0.36 10.2 4.4 0.21 11.0 1.5 1.8 1 1 1 2 2 2 0 VIT family DUF883 PF05957.8 EFE40255.1 - 0.68 10.3 8.9 0.24 11.8 2.7 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) CAF-1_p150 PF11600.3 EFE40255.1 - 1.2 8.5 16.6 1.8 7.9 11.5 1.3 1 1 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF3337 PF11816.3 EFE40255.1 - 1.8 7.8 7.7 2.1 7.6 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Atg14 PF10186.4 EFE40255.1 - 2.4 7.0 6.1 3.3 6.5 4.3 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 FIVAR PF07554.8 EFE40255.1 - 4.6 7.5 9.0 8.6 6.7 0.2 2.6 2 1 0 2 2 2 0 Uncharacterised Sugar-binding Domain DUF3391 PF11871.3 EFE40255.1 - 5.1 7.3 7.5 8.6 6.5 5.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) Herpes_DNAp_acc PF04929.7 EFE40255.1 - 8.1 5.2 8.2 8.8 5.1 5.7 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor 2-oxoacid_dh PF00198.18 EFE40256.1 - 6.2e-75 251.4 0.0 8.1e-75 251.0 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EFE40256.1 - 3.7e-17 61.7 0.3 3.7e-17 61.7 0.2 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.12 EFE40256.1 - 2.1e-15 56.0 0.5 5.1e-15 54.8 0.3 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 EFE40256.1 - 0.078 12.6 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like Sec7 PF01369.15 EFE40257.1 - 6.1e-63 211.9 0.1 2e-62 210.2 0.1 1.9 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 EFE40257.1 - 1.4e-51 174.2 7.3 1.4e-51 174.2 5.1 3.3 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 EFE40257.1 - 5.3e-31 105.9 0.1 5.3e-31 105.9 0.1 5.0 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) NAD_binding_7 PF13241.1 EFE40258.1 - 2.3e-32 111.3 0.2 3.5e-32 110.7 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 EFE40258.1 - 1.4e-28 97.9 0.0 2.1e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 EFE40258.1 - 9.3e-16 56.5 0.1 1.7e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.15 EFE40258.1 - 0.036 14.1 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.16 EFE40258.1 - 0.1 12.4 1.2 0.19 11.5 0.0 1.9 1 1 1 2 2 2 0 ThiF family ELFV_dehydrog PF00208.16 EFE40258.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.5 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Pribosyltran_N PF13793.1 EFE40259.1 - 7.4e-37 125.6 0.1 2.7e-34 117.3 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 EFE40259.1 - 9.4e-34 116.7 0.0 6.5e-29 100.9 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 EFE40259.1 - 4.6e-08 32.8 0.3 2.2e-05 24.1 0.0 2.7 3 0 0 3 3 3 2 Phosphoribosyl transferase domain CbiJ PF02571.9 EFE40259.1 - 0.041 13.1 0.1 0.14 11.4 0.0 1.8 3 0 0 3 3 3 0 Precorrin-6x reductase CbiJ/CobK Med2 PF11214.3 EFE40260.1 - 3.4 7.7 7.3 1 9.4 2.4 1.8 2 0 0 2 2 2 0 Mediator complex subunit 2 Peptidase_S49_N PF08496.5 EFE40260.1 - 6.6 6.5 7.2 1.9 8.2 1.0 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Isochorismatase PF00857.15 EFE40261.1 - 1.8e-20 73.6 0.0 2.2e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Methyltransf_10 PF05971.7 EFE40262.1 - 2.4e-26 92.5 0.1 3.1e-26 92.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF890) Complex1_LYR_1 PF13232.1 EFE40263.1 - 2.1e-08 34.2 2.0 5.4e-08 32.9 1.4 1.7 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 EFE40263.1 - 2.1e-07 30.6 1.4 5.4e-07 29.3 1.0 1.7 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Ank_4 PF13637.1 EFE40264.1 - 4.4e-13 49.3 0.9 1.2e-10 41.5 0.4 3.2 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFE40264.1 - 4.5e-08 33.3 0.0 0.00042 20.5 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFE40264.1 - 3e-07 30.4 5.0 1.5e-05 25.0 0.2 3.6 3 2 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE40264.1 - 0.00088 19.2 3.8 0.061 13.6 0.1 4.5 4 1 0 4 4 4 1 Ankyrin repeat KilA-N PF04383.8 EFE40264.1 - 0.0028 17.2 0.2 0.0028 17.2 0.1 2.6 2 1 0 2 2 2 1 KilA-N domain AceK PF06315.6 EFE40264.1 - 0.033 12.4 2.5 0.12 10.6 0.0 2.0 2 0 0 2 2 2 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) Mtr2 PF10429.4 EFE40264.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 Ank PF00023.25 EFE40264.1 - 0.082 12.7 8.8 0.18 11.7 0.3 4.2 4 1 0 4 4 4 0 Ankyrin repeat DUF342 PF03961.8 EFE40264.1 - 0.54 8.6 6.5 1.1 7.6 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DivIC PF04977.10 EFE40264.1 - 2.1 7.8 6.4 26 4.3 2.9 2.9 2 0 0 2 2 2 0 Septum formation initiator Mnd1 PF03962.10 EFE40264.1 - 2.3 7.8 11.3 2.7 7.5 6.0 2.2 2 0 0 2 2 2 0 Mnd1 family Rick_17kDa_Anti PF05433.10 EFE40265.1 - 0.0036 16.9 25.2 0.019 14.6 17.5 2.1 1 1 1 2 2 2 1 Glycine zipper 2TM domain SR-25 PF10500.4 EFE40265.1 - 0.006 16.0 13.2 0.0081 15.6 9.2 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 EFE40265.1 - 0.027 14.5 19.8 0.048 13.7 13.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) TraT PF05818.7 EFE40265.1 - 0.041 13.2 1.9 0.064 12.6 1.3 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Gly-zipper_Omp PF13488.1 EFE40265.1 - 0.15 11.7 19.0 0.47 10.1 13.1 2.0 1 0 0 1 1 1 0 Glycine zipper BLVR PF06375.6 EFE40265.1 - 0.18 11.5 13.6 0.3 10.9 9.4 1.3 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) DUF1269 PF06897.7 EFE40265.1 - 0.56 10.2 3.5 0.84 9.7 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Med19 PF10278.4 EFE40265.1 - 0.67 9.6 12.8 1.1 8.8 8.9 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TFIIF_alpha PF05793.7 EFE40265.1 - 1 7.6 16.5 1.4 7.2 11.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Transgly_assoc PF04226.8 EFE40265.1 - 3.4 7.8 11.4 6 7.0 7.9 1.3 1 0 0 1 1 1 0 Transglycosylase associated protein Med15 PF09606.5 EFE40265.1 - 5.6 5.0 30.3 6.1 4.9 21.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1275 PF06912.6 EFE40266.1 - 1.9e-32 112.1 15.0 2.3e-31 108.6 10.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1275) TPR_11 PF13414.1 EFE40267.1 - 7.5e-09 35.1 4.5 1.6e-06 27.6 0.0 4.2 3 1 0 4 4 4 1 TPR repeat TPR_1 PF00515.23 EFE40267.1 - 0.0012 18.3 7.2 0.012 15.1 0.0 4.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE40267.1 - 0.0036 17.2 7.0 1.2 9.1 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFE40267.1 - 0.0036 17.3 0.7 0.96 9.8 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE40267.1 - 0.02 14.7 0.0 0.02 14.7 0.0 5.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.1 EFE40267.1 - 0.065 13.0 10.0 0.36 10.7 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE40267.1 - 0.11 13.2 16.5 0.16 12.6 0.0 5.3 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE40267.1 - 0.55 10.6 4.6 8.5 6.7 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFE40267.1 - 0.95 10.2 0.0 0.95 10.2 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat ABC_tran PF00005.22 EFE40268.1 - 2.7e-47 160.4 0.1 3.6e-23 82.3 0.0 3.7 2 2 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE40268.1 - 1.5e-16 60.3 0.1 9.3e-07 28.3 0.0 3.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE40268.1 - 4.8e-16 59.5 1.0 0.0017 18.4 0.1 4.2 3 1 1 4 4 4 3 AAA domain AAA_29 PF13555.1 EFE40268.1 - 4.4e-10 38.9 0.0 0.0012 18.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EFE40268.1 - 2.8e-09 37.5 1.7 0.00042 20.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain DUF258 PF03193.11 EFE40268.1 - 5e-08 32.2 0.1 0.00014 21.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFE40268.1 - 1.9e-07 31.9 0.0 0.0025 18.6 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 EFE40268.1 - 9.3e-07 28.9 0.1 0.012 15.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFE40268.1 - 1.9e-06 27.8 0.0 0.018 15.0 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.1 EFE40268.1 - 2e-06 27.9 0.0 0.025 14.7 0.0 3.5 3 0 0 3 3 2 2 AAA domain AAA PF00004.24 EFE40268.1 - 2.3e-06 27.8 0.3 0.15 12.3 0.0 4.9 6 0 0 6 6 4 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 EFE40268.1 - 4.1e-06 26.6 0.0 0.034 14.0 0.0 3.1 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 EFE40268.1 - 8.1e-06 25.4 0.1 0.22 10.9 0.0 3.3 4 1 0 4 4 4 2 AAA-like domain Miro PF08477.8 EFE40268.1 - 1e-05 26.0 0.0 0.024 15.1 0.0 2.8 2 0 0 2 2 2 1 Miro-like protein AAA_33 PF13671.1 EFE40268.1 - 1.2e-05 25.1 0.0 0.21 11.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain ArgK PF03308.11 EFE40268.1 - 2e-05 23.5 0.1 0.095 11.4 0.0 2.5 2 0 0 2 2 2 2 ArgK protein AAA_18 PF13238.1 EFE40268.1 - 2.1e-05 24.8 0.2 0.4 10.9 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_15 PF13175.1 EFE40268.1 - 2.5e-05 23.5 1.1 0.74 8.7 0.0 3.9 3 2 1 4 4 4 2 AAA ATPase domain NACHT PF05729.7 EFE40268.1 - 3.3e-05 23.6 0.0 0.041 13.5 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.1 EFE40268.1 - 4.9e-05 23.3 2.8 0.47 10.4 0.0 4.3 4 1 0 4 4 4 2 AAA ATPase domain DUF87 PF01935.12 EFE40268.1 - 5e-05 23.2 0.2 0.24 11.1 0.0 3.3 3 0 0 3 3 2 2 Domain of unknown function DUF87 PduV-EutP PF10662.4 EFE40268.1 - 5.6e-05 22.6 0.0 0.12 11.8 0.0 2.9 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 EFE40268.1 - 5.9e-05 22.9 0.0 0.0084 15.9 0.0 2.7 2 0 0 2 2 2 1 Dynamin family RNA_helicase PF00910.17 EFE40268.1 - 0.00015 21.8 0.0 0.66 10.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase MobB PF03205.9 EFE40268.1 - 0.0003 20.5 0.0 1 9.0 0.0 3.1 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 EFE40268.1 - 0.00054 19.8 0.0 2.4 8.0 0.0 3.5 3 1 0 3 3 3 2 AAA domain Arch_ATPase PF01637.13 EFE40268.1 - 0.0008 19.1 0.0 0.58 9.8 0.0 3.0 2 0 0 2 2 2 1 Archaeal ATPase AAA_13 PF13166.1 EFE40268.1 - 0.0023 16.4 3.9 1.5 7.2 0.0 3.8 4 1 0 4 4 4 2 AAA domain cobW PF02492.14 EFE40268.1 - 0.0024 17.3 0.2 1.9 7.9 0.0 3.3 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 EFE40268.1 - 0.0025 17.2 0.0 3.1 7.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.20 EFE40268.1 - 0.0027 17.2 0.0 3 7.2 0.0 2.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF3385 PF11865.3 EFE40268.1 - 0.0057 16.5 0.1 0.049 13.5 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3385) ATP_bind_1 PF03029.12 EFE40268.1 - 0.012 15.1 0.0 4.5 6.7 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.13 EFE40268.1 - 0.012 15.0 0.4 2.7 7.4 0.0 3.4 3 1 0 3 3 3 0 FtsK/SpoIIIE family MutS_V PF00488.16 EFE40268.1 - 0.021 14.2 0.1 1.5 8.2 0.0 2.4 2 0 0 2 2 2 0 MutS domain V AAA_5 PF07728.9 EFE40268.1 - 0.041 13.6 0.0 14 5.3 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.17 EFE40268.1 - 0.054 12.3 0.1 0.55 9.0 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain G-alpha PF00503.15 EFE40268.1 - 0.076 11.6 0.3 0.97 8.0 0.0 2.6 3 0 0 3 3 3 0 G-protein alpha subunit Septin PF00735.13 EFE40268.1 - 0.14 11.1 2.8 1.8 7.4 0.0 3.1 4 0 0 4 4 4 0 Septin HEAT PF02985.17 EFE40268.1 - 0.17 12.0 1.4 28 5.1 0.0 4.1 4 0 0 4 4 3 0 HEAT repeat Mu-like_Pro PF10123.4 EFE40268.1 - 0.44 9.9 11.2 1.6 8.1 7.8 1.9 1 0 0 1 1 1 0 Mu-like prophage I protein IMS PF00817.15 EFE40269.1 - 1.2e-37 128.9 0.0 1.9e-37 128.3 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EFE40269.1 - 6.4e-09 35.8 0.1 3.2e-08 33.5 0.1 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain Reprolysin_4 PF13583.1 EFE40271.1 - 5e-60 202.5 0.6 9.2e-60 201.6 0.4 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 EFE40271.1 - 1.9e-58 197.6 5.7 1.9e-58 197.6 3.9 2.2 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 EFE40271.1 - 4.6e-41 140.7 1.1 4.6e-41 140.7 0.7 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 EFE40271.1 - 1.1e-18 67.9 0.2 2.8e-18 66.6 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.18 EFE40271.1 - 9e-17 61.0 35.9 9e-17 61.0 24.9 4.4 3 2 1 4 4 4 1 Disintegrin EF-hand_7 PF13499.1 EFE40272.1 - 4.7e-15 55.4 0.2 1.3e-08 34.8 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 EFE40272.1 - 2.2e-14 51.5 2.0 5.5e-05 22.1 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 EFE40272.1 - 1.4e-13 49.4 5.3 6.7e-06 25.5 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 EFE40272.1 - 1.1e-11 44.1 1.9 2.3e-09 36.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 EFE40272.1 - 0.0052 16.5 0.0 0.018 14.7 0.0 1.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.1 EFE40272.1 - 0.017 14.4 5.0 0.64 9.4 0.1 2.9 3 0 0 3 3 3 0 EF hand EFhand_Ca_insen PF08726.5 EFE40272.1 - 0.13 12.2 0.1 0.42 10.6 0.0 1.9 2 0 0 2 2 2 0 Ca2+ insensitive EF hand MgsA_C PF12002.3 EFE40273.1 - 1e-57 194.4 0.1 1.7e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA PF00004.24 EFE40273.1 - 5.4e-14 52.5 0.0 1.3e-13 51.3 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFE40273.1 - 1.2e-12 47.4 0.0 3.1e-12 46.0 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 EFE40273.1 - 8.9e-06 25.0 0.2 0.04 13.0 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFE40273.1 - 2.3e-05 24.1 0.0 0.0007 19.3 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 EFE40273.1 - 5.8e-05 22.6 0.0 0.0029 17.0 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.1 EFE40273.1 - 0.00018 21.6 0.7 0.001 19.2 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_3 PF07726.6 EFE40273.1 - 0.00024 20.7 0.0 0.0007 19.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFE40273.1 - 0.00043 19.9 0.2 0.0025 17.5 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 EFE40273.1 - 0.00098 19.0 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EFE40273.1 - 0.001 18.0 0.0 0.0016 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.1 EFE40273.1 - 0.0015 18.5 0.1 0.074 13.0 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain Sigma54_activ_2 PF14532.1 EFE40273.1 - 0.0042 17.1 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain ResIII PF04851.10 EFE40273.1 - 0.012 15.4 0.2 2.3 8.0 0.0 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_17 PF13207.1 EFE40273.1 - 0.014 16.2 0.0 0.042 14.6 0.0 1.8 1 1 1 2 2 2 0 AAA domain TIP49 PF06068.8 EFE40273.1 - 0.017 13.8 0.0 0.048 12.3 0.0 1.6 2 0 0 2 2 2 0 TIP49 C-terminus AAA_30 PF13604.1 EFE40273.1 - 0.021 14.3 0.2 0.18 11.3 0.1 2.3 1 1 1 2 2 2 0 AAA domain PIF1 PF05970.9 EFE40273.1 - 0.03 13.2 0.0 0.06 12.2 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase DUF927 PF06048.6 EFE40273.1 - 0.03 13.5 0.2 0.055 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF927) AAA_18 PF13238.1 EFE40273.1 - 0.05 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFE40273.1 - 0.063 12.9 0.0 4.9 6.7 0.0 2.4 1 1 1 2 2 2 0 Archaeal ATPase NACHT PF05729.7 EFE40273.1 - 0.07 12.7 0.1 0.17 11.5 0.1 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 EFE40273.1 - 0.087 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.17 EFE40273.1 - 0.096 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.11 EFE40273.1 - 0.13 11.4 0.0 0.42 9.8 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein AAA_29 PF13555.1 EFE40273.1 - 0.13 11.7 0.1 7.9 6.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF258 PF03193.11 EFE40273.1 - 0.17 11.0 0.2 2 7.5 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function, DUF258 AAA_13 PF13166.1 EFE40273.1 - 0.27 9.6 0.1 0.43 8.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain Aminotran_1_2 PF00155.16 EFE40274.1 - 1e-53 182.5 0.0 1.2e-53 182.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EFE40274.1 - 0.0072 15.5 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EFE40274.1 - 0.19 10.7 0.1 0.43 9.5 0.0 1.7 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family KH_1 PF00013.24 EFE40275.1 - 1.1e-40 137.1 8.5 6.7e-13 48.0 0.3 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EFE40275.1 - 4e-33 112.4 4.0 8.2e-11 41.3 0.1 3.8 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EFE40275.1 - 2.6e-13 49.3 3.0 0.00023 20.6 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EFE40275.1 - 7.7e-09 35.0 3.4 0.027 14.1 0.1 3.6 3 1 0 3 3 3 3 KH domain KH_5 PF13184.1 EFE40275.1 - 0.00011 21.9 2.1 3.5 7.5 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain dUTPase PF00692.14 EFE40275.1 - 0.011 15.2 0.0 3.7 7.0 0.0 3.2 3 0 0 3 3 3 0 dUTPase Amidoligase_2 PF12224.3 EFE40276.1 - 2e-08 34.2 0.0 3e-06 27.0 0.0 2.7 2 1 0 2 2 2 2 Putative amidoligase enzyme Endonuc-PvuII PF09225.5 EFE40276.1 - 0.099 12.3 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 Restriction endonuclease PvuII DUF3665 PF12427.3 EFE40277.1 - 0.031 13.6 0.0 3.4 7.1 0.0 2.5 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase HHH_3 PF12836.2 EFE40277.1 - 0.059 13.3 0.0 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif Ald_Xan_dh_C2 PF02738.13 EFE40279.1 - 1.3e-182 607.9 0.4 1.8e-182 607.5 0.3 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase CO_deh_flav_C PF03450.12 EFE40279.1 - 7.5e-34 115.7 0.1 5.2e-33 113.0 0.0 2.3 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain FAD_binding_5 PF00941.16 EFE40279.1 - 1.5e-29 102.6 0.0 1.2e-17 63.9 0.0 2.4 1 1 1 2 2 2 2 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.17 EFE40279.1 - 1e-28 99.6 0.0 2.2e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.15 EFE40279.1 - 3.7e-28 97.2 0.0 1e-27 95.8 0.0 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.22 EFE40279.1 - 4.6e-09 35.9 0.4 1.4e-08 34.3 0.1 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Sigma70_r3 PF04539.11 EFE40279.1 - 0.055 13.3 0.1 0.79 9.6 0.0 2.7 2 0 0 2 2 2 0 Sigma-70 region 3 AMP-binding PF00501.23 EFE40280.1 - 9.2e-74 248.2 0.0 1.3e-73 247.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 EFE40280.1 - 4.4e-56 189.5 0.0 2.3e-51 174.1 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein PP-binding PF00550.20 EFE40280.1 - 6.5e-12 45.5 0.0 1.8e-11 44.1 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE40280.1 - 7.1e-08 33.2 0.0 2.4e-07 31.6 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.16 EFE40280.1 - 9.7e-08 31.7 0.0 2.1e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFE40280.1 - 0.00069 18.3 0.0 0.0018 17.0 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Condensation PF00668.15 EFE40280.1 - 0.0024 16.7 0.0 0.0045 15.8 0.0 1.4 1 0 0 1 1 1 1 Condensation domain NAD_binding_10 PF13460.1 EFE40280.1 - 0.064 13.2 0.0 0.5 10.3 0.0 2.3 1 1 0 1 1 1 0 NADH(P)-binding AAA_17 PF13207.1 EFE40281.1 - 2.5e-05 25.0 0.0 5.3e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EFE40281.1 - 0.00021 21.6 0.0 0.00032 20.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.1 EFE40281.1 - 0.00063 20.0 0.0 0.009 16.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 EFE40281.1 - 0.00092 18.8 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.1 EFE40281.1 - 0.022 14.7 0.4 0.052 13.5 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 EFE40281.1 - 0.033 14.3 0.1 0.26 11.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFE40281.1 - 0.035 14.0 0.6 0.13 12.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EFE40281.1 - 0.051 13.1 0.2 0.1 12.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 EFE40281.1 - 0.1 12.5 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EFE40281.1 - 0.13 12.5 0.2 0.28 11.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.18 EFE40282.1 - 1.1e-34 119.6 0.0 1.6e-30 105.9 0.0 2.5 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE40282.1 - 0.00026 20.8 0.0 0.001 18.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HMG_box PF00505.14 EFE40283.1 - 2.8e-18 65.9 0.0 5.4e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFE40283.1 - 0.0032 17.7 0.0 0.0073 16.6 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain Ribosomal_S6e PF01092.14 EFE40284.1 - 3.6e-49 165.6 0.1 8.2e-49 164.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S6e DUF2992 PF11208.3 EFE40284.1 - 0.45 10.4 9.1 0.68 9.8 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Pribosyl_synth PF14572.1 EFE40285.1 - 1.9e-43 148.3 1.0 1.4e-36 125.9 0.3 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 EFE40285.1 - 2.9e-43 146.3 1.0 3.3e-40 136.4 0.1 2.9 2 1 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 EFE40285.1 - 2.8e-14 52.8 0.8 2.5e-13 49.8 0.3 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EFE40285.1 - 0.00086 18.5 0.2 0.0018 17.5 0.1 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF913 PF06025.7 EFE40286.1 - 1.5e-133 445.2 0.0 1.5e-133 445.2 0.0 4.6 6 1 1 7 7 7 1 Domain of Unknown Function (DUF913) HECT PF00632.20 EFE40286.1 - 4e-95 318.6 0.0 6.8e-95 317.8 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.7 EFE40286.1 - 2.1e-83 280.3 3.8 2.1e-83 280.3 2.6 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF908) DUF4414 PF14377.1 EFE40286.1 - 1.8e-33 114.6 8.4 1.8e-33 114.6 5.8 3.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4414) UBA PF00627.26 EFE40286.1 - 0.00014 21.5 0.0 0.00043 20.0 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain An_peroxidase PF03098.10 EFE40287.1 - 2.8e-79 266.9 0.0 4.4e-79 266.2 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase Steroid_dh PF02544.11 EFE40288.1 - 9.1e-32 109.9 0.3 1.2e-31 109.5 0.2 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 EFE40288.1 - 2.7e-06 26.8 0.4 3.3e-06 26.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 EFE40288.1 - 4.7e-06 26.6 0.3 1.1e-05 25.4 0.2 1.7 1 0 0 1 1 1 1 Phospholipid methyltransferase Halogen_Hydrol PF10112.4 EFE40288.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Glyco_transf_34 PF05637.7 EFE40289.1 - 5.5e-58 196.2 0.0 6.8e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 EFE40289.1 - 0.059 12.6 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF273 Ribosomal_L28 PF00830.14 EFE40290.1 - 9.9e-18 63.7 0.3 2.3e-17 62.5 0.2 1.7 1 0 0 1 1 1 1 Ribosomal L28 family TIP49 PF06068.8 EFE40291.1 - 2.9e-164 546.5 0.2 3.4e-164 546.3 0.2 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 EFE40291.1 - 1.2e-11 44.9 0.2 1.9e-07 31.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFE40291.1 - 1.3e-06 27.6 2.0 0.0073 15.3 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EFE40291.1 - 6e-06 26.3 0.0 0.017 15.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 EFE40291.1 - 8.7e-06 25.9 0.1 0.086 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 EFE40291.1 - 0.00013 21.9 0.1 0.00033 20.6 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE40291.1 - 0.00019 21.1 0.1 0.0005 19.7 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 EFE40291.1 - 0.00055 19.6 0.2 0.16 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EFE40291.1 - 0.0012 17.9 0.2 0.0031 16.6 0.1 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.1 EFE40291.1 - 0.0026 17.2 0.0 0.0045 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 EFE40291.1 - 0.0048 16.3 0.0 3.3 7.1 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.16 EFE40291.1 - 0.014 14.5 0.1 0.71 9.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 EFE40291.1 - 0.017 15.4 0.4 0.19 12.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain KaiC PF06745.8 EFE40291.1 - 0.018 14.1 0.6 0.11 11.5 0.0 2.4 3 0 0 3 3 3 0 KaiC DnaB_C PF03796.10 EFE40291.1 - 0.019 13.8 0.0 0.043 12.6 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain DUF2075 PF09848.4 EFE40291.1 - 0.02 13.8 0.1 0.047 12.6 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.12 EFE40291.1 - 0.027 13.8 0.3 0.062 12.7 0.2 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.1 EFE40291.1 - 0.038 14.8 0.0 0.12 13.1 0.0 1.9 2 1 0 2 2 1 0 AAA domain AAA_33 PF13671.1 EFE40291.1 - 0.15 11.9 0.0 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain V-SNARE PF05008.10 EFE40292.1 - 3.4e-23 81.5 7.3 3.4e-23 81.5 5.0 2.0 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 EFE40292.1 - 2.5e-15 56.2 2.0 2.5e-15 56.2 1.4 2.8 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Effector_1 PF04518.7 EFE40292.1 - 0.023 13.6 1.6 0.027 13.4 1.1 1.2 1 0 0 1 1 1 0 Effector from type III secretion system DUF3829 PF12889.2 EFE40292.1 - 0.028 13.6 1.8 0.036 13.2 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) DUF825 PF05695.7 EFE40292.1 - 0.045 11.1 0.2 0.041 11.2 0.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF825) RHH_1 PF01402.16 EFE40292.1 - 0.14 12.1 3.0 0.29 11.1 0.6 2.5 1 1 1 2 2 2 0 Ribbon-helix-helix protein, copG family ApoLp-III PF07464.6 EFE40292.1 - 0.19 11.7 6.4 1 9.3 3.1 2.1 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Phe_tRNA-synt_N PF02912.13 EFE40292.1 - 0.23 11.1 3.3 4.7 7.0 1.2 2.6 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain zf-C4H2 PF10146.4 EFE40292.1 - 1.9 8.4 6.1 0.55 10.2 1.6 1.8 1 1 1 2 2 2 0 Zinc finger-containing protein DUF501 PF04417.7 EFE40292.1 - 2.5 7.9 9.0 1.5 8.6 1.0 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF501) Histone_HNS PF00816.16 EFE40292.1 - 2.5 8.6 7.1 0.28 11.7 1.6 1.8 2 0 0 2 2 2 0 H-NS histone family DUF349 PF03993.7 EFE40292.1 - 2.8 8.1 8.5 24 5.1 2.4 2.8 2 1 1 3 3 3 0 Domain of Unknown Function (DUF349) TBCA PF02970.11 EFE40292.1 - 3.5 7.7 9.3 1 9.4 1.8 2.6 2 1 1 3 3 3 0 Tubulin binding cofactor A DUF1542 PF07564.6 EFE40292.1 - 5.9 6.9 9.3 2.5 8.1 3.3 2.6 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1542) DUF2407_C PF13373.1 EFE40293.1 - 1.6e-43 147.9 0.1 2.4e-43 147.3 0.0 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.4 EFE40293.1 - 1.6e-33 114.7 0.0 2.6e-33 114.0 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.18 EFE40293.1 - 0.00058 19.2 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.1 EFE40293.1 - 0.037 13.9 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Fe-S_biosyn PF01521.15 EFE40294.1 - 2.6e-17 62.7 0.0 1e-16 60.8 0.0 1.9 3 0 0 3 3 3 1 Iron-sulphur cluster biosynthesis 2OG-Fe_Oxy_2 PF10014.4 EFE40295.1 - 6.5e-50 169.2 0.1 7.8e-50 168.9 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe dioxygenase MFS_1 PF07690.11 EFE40296.1 - 2.6e-30 105.3 44.1 2.6e-30 105.3 30.5 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40296.1 - 4.8e-14 51.7 12.5 4.8e-14 51.7 8.7 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter DUF1741 PF08427.5 EFE40297.1 - 1.3e-80 270.3 1.6 2.6e-80 269.3 0.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1741) MRG PF05712.8 EFE40298.1 - 2.5e-50 170.1 0.0 3.8e-50 169.5 0.0 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 EFE40298.1 - 4.1e-07 29.6 2.3 4.1e-07 29.6 1.6 1.8 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Cnl2_NKP2 PF09447.5 EFE40299.1 - 1.2e-27 95.3 1.3 2.1e-27 94.5 0.9 1.4 1 0 0 1 1 1 1 Cnl2/NKP2 family protein ATG16 PF08614.6 EFE40299.1 - 0.0054 16.5 0.8 0.0065 16.3 0.6 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF972 PF06156.8 EFE40299.1 - 0.11 12.8 0.3 14 6.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Ctf8 PF09696.5 EFE40301.1 - 6.4e-37 126.0 0.0 8.8e-37 125.5 0.0 1.2 1 0 0 1 1 1 1 Ctf8 Glyoxalase PF00903.20 EFE40302.1 - 3.5e-15 56.0 0.0 2.4e-13 50.1 0.0 2.6 2 2 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EFE40302.1 - 6.2e-09 35.8 0.0 4.6e-05 23.4 0.0 2.9 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EFE40302.1 - 2e-07 31.6 0.0 0.00068 20.2 0.0 3.1 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.1 EFE40302.1 - 6e-05 23.0 0.0 0.26 11.1 0.0 3.2 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.1 EFE40302.1 - 0.00063 19.6 0.1 0.0098 15.8 0.0 2.6 3 0 0 3 3 3 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal DUF3813 PF12758.2 EFE40302.1 - 0.094 12.8 0.8 0.22 11.6 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) RabGAP-TBC PF00566.13 EFE40303.1 - 7.9e-49 166.0 0.1 7.9e-49 166.0 0.1 2.8 3 1 1 4 4 4 1 Rab-GTPase-TBC domain PPTA PF01239.17 EFE40304.1 - 2.4e-33 112.0 7.0 1.3e-08 33.7 0.3 4.9 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat APH PF01636.18 EFE40305.1 - 1.6e-16 60.7 0.1 2.2e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE40305.1 - 3.8e-05 23.3 0.0 6.7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.20 EFE40305.1 - 0.0012 18.0 0.0 0.27 10.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain DUF1679 PF07914.6 EFE40305.1 - 0.0027 16.3 0.3 0.4 9.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.9 EFE40305.1 - 0.03 13.3 0.0 0.046 12.6 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase Pkinase_Tyr PF07714.12 EFE40305.1 - 0.057 12.4 0.1 0.53 9.3 0.0 2.0 1 1 0 1 1 1 0 Protein tyrosine kinase WD40 PF00400.27 EFE40306.1 - 1.6e-14 53.1 6.0 2.9e-08 33.2 0.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat Utp12 PF04003.7 EFE40307.1 - 1.2e-22 79.8 1.3 3e-22 78.5 0.5 2.0 2 0 0 2 2 2 1 Dip2/Utp12 Family CENP-T PF15511.1 EFE40307.1 - 7.8 5.6 31.1 0.2 10.8 1.1 2.2 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T Bromodomain PF00439.20 EFE40308.1 - 5.8e-42 141.5 1.1 1.8e-23 82.2 0.3 2.6 2 0 0 2 2 2 2 Bromodomain DUF3573 PF12097.3 EFE40308.1 - 0.071 11.7 0.8 0.13 10.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Frataxin_Cyay PF01491.11 EFE40309.1 - 1e-31 108.9 0.0 1.6e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain DUF1192 PF06698.6 EFE40309.1 - 0.096 12.5 0.4 0.22 11.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) AKAP7_NLS PF10469.4 EFE40310.1 - 2.6e-16 59.9 0.0 4.3e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Sec6 PF06046.8 EFE40311.1 - 2e-169 564.3 3.6 2e-169 564.3 2.5 1.8 2 0 0 2 2 2 1 Exocyst complex component Sec6 Ribosomal_L30 PF00327.15 EFE40312.1 - 5.6e-14 51.4 0.2 7.8e-14 50.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Pyridoxal_deC PF00282.14 EFE40313.1 - 5.1e-16 58.0 0.0 9.7e-16 57.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.12 EFE40313.1 - 2.1e-06 27.0 0.1 3.3e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EFE40313.1 - 2.8e-06 26.3 0.0 2.5e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EFE40313.1 - 0.0027 16.6 0.0 0.0063 15.5 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EFE40313.1 - 0.11 10.8 0.0 0.19 9.9 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EFE40314.1 - 2.8e-85 286.4 0.0 3.4e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1604 PF07713.8 EFE40316.1 - 1.5e-40 136.8 12.0 5.6e-40 135.0 1.9 4.0 4 0 0 4 4 4 1 Protein of unknown function (DUF1604) G-patch PF01585.18 EFE40316.1 - 4.4e-08 32.7 1.0 1.7e-07 30.8 0.4 2.3 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.2 EFE40316.1 - 0.027 14.3 0.4 0.027 14.3 0.3 3.5 2 1 1 3 3 3 0 DExH-box splicing factor binding site SLT_2 PF13406.1 EFE40316.1 - 0.042 12.7 0.0 0.074 11.9 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain SSP160 PF06933.6 EFE40316.1 - 2.9 5.7 8.9 5.6 4.8 6.1 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Pkinase PF00069.20 EFE40317.1 - 1.9e-70 237.0 0.1 1.7e-69 233.8 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40317.1 - 5.9e-38 130.4 0.0 1.6e-37 128.9 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.14 EFE40317.1 - 3.6e-17 61.5 0.2 6e-17 60.8 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.9 EFE40317.1 - 1.6e-06 27.3 0.0 3.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE40317.1 - 2.4e-05 23.4 0.0 0.00013 21.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EFE40317.1 - 0.0018 18.0 0.1 0.038 13.7 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 EFE40317.1 - 0.0052 16.0 0.1 0.0086 15.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 EFE40317.1 - 0.009 15.3 0.4 0.024 13.9 0.3 1.7 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 EFE40317.1 - 0.017 14.4 0.0 0.034 13.4 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Ribos_L4_asso_C PF14374.1 EFE40317.1 - 0.018 14.8 0.2 0.19 11.6 0.0 2.4 2 0 0 2 2 2 0 60S ribosomal protein L4 C-terminal domain DAGK_cat PF00781.19 EFE40318.1 - 1.4e-23 82.7 0.1 2.3e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF1180 PF06679.7 EFE40319.1 - 0.088 12.6 0.4 5.2 6.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) NfeD PF01957.13 EFE40319.1 - 0.28 11.3 0.1 0.28 11.3 0.0 2.7 3 0 0 3 3 3 0 NfeD-like C-terminal, partner-binding Adaptin_N PF01602.15 EFE40320.1 - 4.5e-94 315.6 11.0 4.5e-94 315.6 7.6 1.5 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 EFE40320.1 - 1.9e-61 205.5 0.0 8.7e-61 203.3 0.0 2.2 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 EFE40320.1 - 4.4e-61 204.6 1.1 9.8e-61 203.5 0.7 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 EFE40320.1 - 6e-12 45.6 9.0 7.6e-08 32.5 0.0 4.4 2 1 2 4 4 4 3 HEAT repeats Cnd1 PF12717.2 EFE40320.1 - 9.8e-06 25.5 10.2 0.0054 16.6 0.0 4.1 3 2 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 EFE40320.1 - 1.2e-05 25.6 4.5 0.0008 19.8 0.1 4.9 4 1 1 5 5 5 2 HEAT-like repeat HEAT PF02985.17 EFE40320.1 - 0.00023 20.9 1.1 0.41 10.8 0.0 4.7 5 0 0 5 5 4 1 HEAT repeat DUF1542 PF07564.6 EFE40320.1 - 0.0057 16.6 2.4 0.021 14.8 1.7 2.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1542) AP4E_app_platf PF14807.1 EFE40320.1 - 0.041 14.1 0.1 0.18 12.0 0.1 2.2 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Arm PF00514.18 EFE40320.1 - 0.1 12.4 0.7 9.9 6.1 0.0 4.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat RE_Alw26IDE PF09665.5 EFE40320.1 - 0.19 10.4 6.5 2.8 6.5 0.1 3.0 3 1 0 3 3 3 0 Type II restriction endonuclease (RE_Alw26IDE) Vac_ImportDeg PF09783.4 EFE40321.1 - 1.6e-63 213.3 1.5 2.8e-63 212.6 1.1 1.3 1 0 0 1 1 1 1 Vacuolar import and degradation protein Mago_nashi PF02792.9 EFE40321.1 - 2.8e-58 195.7 0.4 2.8e-58 195.7 0.2 1.8 2 0 0 2 2 2 1 Mago nashi protein DUF2236 PF09995.4 EFE40322.1 - 2.4e-08 33.5 0.0 5.3e-08 32.4 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) AGT PF11440.3 EFE40322.1 - 0.056 12.3 0.0 0.08 11.8 0.0 1.2 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase Methyltransf_31 PF13847.1 EFE40323.1 - 2.5e-11 43.4 0.0 3.5e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40323.1 - 4.5e-09 36.2 0.0 5.6e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40323.1 - 8.9e-08 32.5 0.0 1.7e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE40323.1 - 2.3e-07 31.3 0.0 6.8e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE40323.1 - 1.9e-05 25.0 0.0 3.8e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE40323.1 - 0.0059 16.6 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE40323.1 - 0.024 13.7 0.0 0.057 12.5 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CheR PF01739.13 EFE40323.1 - 0.03 13.6 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_25 PF13649.1 EFE40323.1 - 0.034 14.4 0.0 0.097 13.0 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Isochorismatase PF00857.15 EFE40324.1 - 3.2e-34 118.3 0.1 9.7e-34 116.7 0.0 1.7 2 0 0 2 2 2 1 Isochorismatase family Iso_dh PF00180.15 EFE40324.1 - 3.9e-13 49.0 0.0 5.7e-12 45.2 0.0 2.1 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase TK PF00265.13 EFE40324.1 - 0.059 12.9 0.0 0.32 10.5 0.0 2.1 2 0 0 2 2 2 0 Thymidine kinase Methyltransf_25 PF13649.1 EFE40325.1 - 5e-11 42.8 0.1 1.1e-10 41.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40325.1 - 7.2e-08 32.3 0.0 1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE40325.1 - 3.7e-06 26.5 0.0 4.7e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE40325.1 - 9.1e-06 26.0 0.0 1.5e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40325.1 - 2.2e-05 24.8 0.0 3.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE40325.1 - 0.00067 20.2 0.0 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE40325.1 - 0.0057 15.8 0.0 0.0075 15.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFE40325.1 - 0.0095 15.9 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 EFE40325.1 - 0.13 11.2 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Abhydrolase_6 PF12697.2 EFE40326.1 - 4.2e-11 43.1 0.0 5.1e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE40326.1 - 7.7e-08 32.1 0.0 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Rad60-SLD PF11976.3 EFE40328.1 - 3.7e-14 52.1 0.2 5.3e-14 51.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EFE40328.1 - 0.00017 20.9 0.1 0.00025 20.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Nup84_Nup100 PF04121.8 EFE40329.1 - 4.6e-60 203.1 0.9 3.7e-59 200.0 0.6 2.4 1 1 0 1 1 1 1 Nuclear pore protein 84 / 107 Nop14 PF04147.7 EFE40329.1 - 1.7 6.5 19.9 2.9 5.6 13.8 1.4 1 0 0 1 1 1 0 Nop14-like family E1-E2_ATPase PF00122.15 EFE40330.1 - 1.6e-58 197.4 2.9 3.7e-58 196.2 2.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE40330.1 - 8.9e-45 152.4 4.6 8.9e-45 152.4 3.2 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE40330.1 - 2.6e-27 96.6 0.0 2e-26 93.7 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE40330.1 - 6.4e-21 74.1 0.0 1.3e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE40330.1 - 5.3e-13 49.5 0.0 1.4e-12 48.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFE40330.1 - 1.9e-06 27.2 0.0 1.3e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EFE40330.1 - 1.2e-05 25.0 0.4 5.2e-05 22.9 0.3 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3325 PF11804.3 EFE40330.1 - 0.0043 16.9 0.3 0.23 11.3 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3325) YjgP_YjgQ PF03739.9 EFE40330.1 - 0.016 13.9 3.7 0.08 11.6 2.9 1.8 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family OPA3 PF07047.7 EFE40331.1 - 0.031 14.0 0.8 0.05 13.3 0.6 1.2 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Ligase_CoA PF00549.14 EFE40332.1 - 2.5e-34 118.0 1.8 1.3e-18 67.0 0.1 2.4 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.14 EFE40332.1 - 3.4e-13 49.9 2.7 7.1e-13 48.8 0.2 2.6 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.1 EFE40332.1 - 2.4e-08 33.6 0.9 2.3e-06 27.2 0.1 2.9 2 1 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 EFE40332.1 - 0.0094 16.1 0.1 0.023 14.8 0.1 1.7 1 0 0 1 1 1 1 CoA binding domain 4HBT PF03061.17 EFE40333.1 - 1.4e-10 41.1 0.0 2.5e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily V-ATPase_C PF03223.10 EFE40334.1 - 1.1e-115 386.5 0.0 1.2e-115 386.3 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C mRNA_cap_C PF03919.10 EFE40334.1 - 0.071 13.4 0.4 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 mRNA capping enzyme, C-terminal domain APS_kinase PF01583.15 EFE40335.1 - 1.2e-54 184.1 0.0 2e-54 183.4 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.1 EFE40335.1 - 1.5e-05 25.3 1.1 9.9e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE40335.1 - 2.1e-05 24.4 0.5 7.4e-05 22.6 0.0 2.3 3 1 0 3 3 3 1 AAA domain AAA_17 PF13207.1 EFE40335.1 - 4.6e-05 24.2 1.7 0.00022 22.0 1.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFE40335.1 - 0.00059 19.3 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 EFE40335.1 - 0.0016 18.7 0.9 0.018 15.3 0.0 2.5 2 1 0 2 2 2 1 ABC transporter KTI12 PF08433.5 EFE40335.1 - 0.032 13.4 0.1 0.12 11.5 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_14 PF13173.1 EFE40335.1 - 0.034 14.0 0.2 3.3 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EFE40335.1 - 0.048 13.8 0.0 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.1 EFE40335.1 - 0.32 10.9 5.0 0.33 10.9 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain GCV_T PF01571.16 EFE40336.1 - 7.5e-55 185.5 0.0 1e-54 185.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 EFE40336.1 - 3.7e-19 68.5 0.3 8.3e-19 67.4 0.2 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Aa_trans PF01490.13 EFE40337.1 - 3.5e-20 71.8 42.8 1.7e-15 56.4 20.6 2.5 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein S1FA PF04689.8 EFE40337.1 - 9.2 6.2 5.8 1.3 8.9 0.5 2.1 2 0 0 2 2 2 0 DNA binding protein S1FA Ank_2 PF12796.2 EFE40338.1 - 1.4e-103 339.4 23.3 6.6e-16 58.4 0.0 8.2 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE40338.1 - 5.6e-59 195.5 4.5 1.7e-08 34.7 0.0 9.7 7 2 2 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE40338.1 - 2.2e-57 189.7 6.5 9.2e-08 32.0 0.1 10.3 5 1 4 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.25 EFE40338.1 - 4.5e-57 187.1 5.9 2e-05 24.1 0.1 15.0 15 0 0 15 15 15 12 Ankyrin repeat Ank_3 PF13606.1 EFE40338.1 - 5.3e-45 146.9 3.2 0.0017 18.4 0.0 13.8 15 0 0 15 15 15 12 Ankyrin repeat Phage_holin_6 PF10746.4 EFE40338.1 - 0.075 12.7 0.1 0.24 11.1 0.1 1.8 1 0 0 1 1 1 0 Phage holin family 6 DUF3902 PF13042.1 EFE40338.1 - 0.14 11.4 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3902) DUF812 PF05667.6 EFE40341.1 - 0.00076 18.1 8.3 0.12 10.8 3.6 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF812) Fe-ADH_2 PF13685.1 EFE40341.1 - 0.0022 17.3 0.3 0.011 15.0 0.1 2.0 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase DUF572 PF04502.8 EFE40341.1 - 0.03 13.5 3.9 0.043 13.0 2.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Reo_sigmaC PF04582.7 EFE40341.1 - 0.43 9.7 6.7 0.3 10.2 0.3 2.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF1993 PF09351.5 EFE40341.1 - 1.4 8.8 5.0 0.56 10.1 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1993) UPF0449 PF15136.1 EFE40341.1 - 1.8 8.8 10.3 6.3 7.0 0.0 3.8 3 1 0 3 3 3 0 Uncharacterised protein family UPF0449 Noelin-1 PF12308.3 EFE40341.1 - 2.9 7.7 8.2 9.9 6.0 1.1 3.3 2 1 1 3 3 3 0 Neurogenesis glycoprotein Baculo_PEP_C PF04513.7 EFE40341.1 - 8.8 6.1 20.6 0.27 11.0 4.9 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Topoisom_bac PF01131.15 EFE40343.1 - 1.2e-81 274.6 0.0 5.3e-81 272.5 0.0 1.8 2 0 0 2 2 2 1 DNA topoisomerase Toprim PF01751.17 EFE40343.1 - 1.6e-11 44.0 0.0 2.8e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Toprim domain MFS_1 PF07690.11 EFE40344.1 - 1.8e-43 148.5 57.0 3.7e-42 144.2 37.8 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40344.1 - 4.6e-10 38.6 38.5 4.4e-07 28.8 14.7 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.8 EFE40344.1 - 4.4e-06 25.1 22.1 6.9e-06 24.5 15.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GATase PF00117.23 EFE40345.1 - 9.8e-13 47.9 0.0 1.2e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EFE40345.1 - 0.019 14.4 0.1 0.056 12.8 0.1 1.8 1 1 0 1 1 1 0 Peptidase C26 GATase_3 PF07685.9 EFE40345.1 - 0.072 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DUF775 PF05603.7 EFE40346.1 - 8.6e-64 214.7 0.0 9.7e-64 214.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) NUDIX PF00293.23 EFE40347.1 - 7.9e-09 35.2 0.0 2e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain FlgM PF04316.8 EFE40347.1 - 0.077 12.9 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM DUF1573 PF07610.6 EFE40347.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) RNA_pol_Rpb8 PF03870.10 EFE40348.1 - 1.1e-36 126.1 0.0 1.2e-36 125.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 PAXNEB PF05625.6 EFE40349.1 - 8.1e-123 409.8 0.0 8.9e-123 409.7 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein tRNA_int_endo PF01974.12 EFE40350.1 - 1.4e-15 56.8 0.0 2.8e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain MAT1 PF06391.8 EFE40350.1 - 0.011 15.2 2.6 0.015 14.8 1.8 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 UPF0086 PF01868.11 EFE40351.1 - 8.6e-09 34.9 0.3 1e-05 25.0 0.0 2.6 2 1 1 3 3 3 2 Domain of unknown function UPF0086 Copper-bind PF00127.15 EFE40352.1 - 0.012 15.8 0.2 0.034 14.3 0.2 1.8 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family DUF1325 PF07039.6 EFE40352.1 - 0.095 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 SGF29 tudor-like domain DUF605 PF04652.11 EFE40352.1 - 1.4 8.2 6.6 1.8 7.8 4.5 1.1 1 0 0 1 1 1 0 Vta1 like Tmemb_cc2 PF10267.4 EFE40352.1 - 3.4 6.1 4.2 4.1 5.9 2.9 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Macoilin PF09726.4 EFE40352.1 - 5.9 5.0 6.7 6.5 4.9 4.6 1.0 1 0 0 1 1 1 0 Transmembrane protein Ank_2 PF12796.2 EFE40353.1 - 3.5e-74 245.1 14.6 5.1e-12 45.9 0.0 6.7 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE40353.1 - 4.9e-48 160.6 10.0 1.6e-08 34.8 0.0 8.6 4 3 5 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE40353.1 - 7.5e-45 149.9 7.7 5.1e-11 42.4 0.0 6.6 3 2 3 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.25 EFE40353.1 - 4.9e-39 130.2 4.9 0.00016 21.3 0.0 10.3 11 0 0 11 11 11 9 Ankyrin repeat Ank_3 PF13606.1 EFE40353.1 - 2.9e-25 85.8 1.0 0.00043 20.2 0.0 9.3 10 0 0 10 10 10 4 Ankyrin repeat Trehalase_Ca-bi PF07492.6 EFE40353.1 - 1.5e-05 24.1 1.0 0.31 10.3 0.0 4.5 4 0 0 4 4 4 1 Neutral trehalase Ca2+ binding domain LysR_substrate PF03466.15 EFE40353.1 - 0.051 12.6 0.2 0.12 11.4 0.1 1.7 2 0 0 2 2 2 0 LysR substrate binding domain YscJ_FliF PF01514.12 EFE40353.1 - 0.11 11.6 0.8 2.1 7.4 0.1 3.3 3 1 1 4 4 4 0 Secretory protein of YscJ/FliF family MFS_1 PF07690.11 EFE40354.1 - 1.5e-08 33.7 15.9 0.0002 20.2 5.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Tmemb_170 PF10190.4 EFE40354.1 - 0.002 18.1 3.4 0.002 18.1 2.4 2.2 2 0 0 2 2 2 1 Putative transmembrane protein 170 zf-HC5HC2H PF13771.1 EFE40355.1 - 9.1e-05 22.5 13.5 0.0017 18.4 2.1 2.5 2 0 0 2 2 2 2 PHD-like zinc-binding domain FYVE_2 PF02318.11 EFE40355.1 - 0.24 11.3 14.8 0.41 10.5 2.5 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger zf-C3HC4_2 PF13923.1 EFE40355.1 - 2.8 8.0 23.7 9.3 6.3 5.8 3.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) MoCF_biosynth PF00994.19 EFE40358.1 - 0.094 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Probable molybdopterin binding domain GATase PF00117.23 EFE40359.1 - 7.9e-47 159.2 0.0 1.5e-46 158.2 0.0 1.5 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.17 EFE40359.1 - 1.5e-44 150.6 0.0 4.9e-44 149.0 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.8 EFE40359.1 - 4.2e-06 26.3 0.2 0.00029 20.3 0.1 2.4 1 1 0 1 1 1 1 Peptidase C26 RNA_pol_I_A49 PF06870.7 EFE40360.1 - 2.4e-49 167.9 0.0 2.9e-48 164.3 0.0 2.2 1 1 0 1 1 1 1 A49-like RNA polymerase I associated factor Aminotran_1_2 PF00155.16 EFE40361.1 - 6.3e-86 288.5 0.1 1.1e-85 287.8 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EFE40361.1 - 1.4e-06 26.8 0.0 2.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EFE40361.1 - 5.1e-05 22.4 0.2 9.7e-05 21.5 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EFE40361.1 - 6.6e-05 21.8 0.0 0.00013 20.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EFE40361.1 - 0.0065 15.6 1.0 0.024 13.7 0.4 1.9 1 1 0 2 2 2 1 Beta-eliminating lyase p450 PF00067.17 EFE40362.1 - 6.4e-21 74.4 0.0 7.9e-21 74.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CDI PF02234.14 EFE40362.1 - 0.05 13.3 0.3 0.13 12.1 0.2 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor p450 PF00067.17 EFE40363.1 - 1.4e-64 218.3 0.0 1.8e-64 217.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Vps54 PF07928.7 EFE40364.1 - 2.1e-38 131.5 0.4 6.7e-38 129.8 0.3 2.0 1 0 0 1 1 1 1 Vps54-like protein DUF2450 PF10475.4 EFE40364.1 - 0.00015 20.8 1.0 0.00015 20.8 0.7 2.0 2 0 0 2 2 2 1 Protein of unknown function N-terminal domain (DUF2450) SNF2_N PF00176.18 EFE40365.1 - 3.5e-81 272.2 0.7 3.5e-81 272.2 0.5 2.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.20 EFE40365.1 - 1.6e-24 85.5 0.2 1.4e-23 82.6 0.3 2.3 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.1 EFE40365.1 - 1.4e-17 63.5 0.4 1.4e-17 63.5 0.3 3.7 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex Helicase_C PF00271.26 EFE40365.1 - 3.2e-17 62.1 0.0 2.8e-16 59.1 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.8 EFE40365.1 - 6.3e-16 57.9 9.8 6.3e-16 57.9 6.8 2.5 2 0 0 2 2 2 1 HSA QLQ PF08880.6 EFE40365.1 - 3.9e-13 48.5 5.3 2e-12 46.3 3.7 2.4 1 0 0 1 1 1 1 QLQ BAR PF03114.13 EFE40366.1 - 1.9e-33 115.9 13.9 2e-32 112.5 9.6 2.0 1 1 0 1 1 1 1 BAR domain BAR_2 PF10455.4 EFE40366.1 - 4.1e-07 29.2 6.7 6.1e-07 28.6 4.6 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking MscS_TM PF12794.2 EFE40366.1 - 4.4 5.8 4.2 7.8 4.9 2.9 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Ada_Zn_binding PF02805.11 EFE40368.1 - 7e-29 99.2 4.3 1.2e-28 98.4 3.0 1.4 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.18 EFE40368.1 - 2.9e-07 30.1 0.0 5.8e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.2 EFE40368.1 - 0.0017 18.4 0.0 0.0035 17.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain Ribosomal_L2_C PF03947.13 EFE40369.1 - 3.4e-37 127.1 4.5 5.7e-37 126.4 3.1 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EFE40369.1 - 1.3e-12 47.5 0.1 2.7e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain WHIM1 PF15612.1 EFE40370.1 - 0.00038 20.2 0.0 0.00078 19.2 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 WHIM2 PF15613.1 EFE40370.1 - 0.047 13.6 1.1 0.11 12.4 0.2 2.0 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 2 Nop14 PF04147.7 EFE40370.1 - 0.29 9.0 3.1 0.42 8.4 2.2 1.4 1 0 0 1 1 1 0 Nop14-like family PfkB PF00294.19 EFE40371.1 - 1.3e-64 218.2 0.2 1.6e-64 217.9 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 EFE40371.1 - 9.8e-06 24.9 0.0 1.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase EST1_DNA_bind PF10373.4 EFE40372.1 - 1.3e-56 191.9 4.5 2.2e-56 191.1 3.1 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.4 EFE40372.1 - 1.3e-16 60.7 0.1 3.7e-16 59.3 0.1 1.8 1 0 0 1 1 1 1 Telomerase activating protein Est1 TPR_11 PF13414.1 EFE40372.1 - 0.011 15.4 0.5 0.033 13.8 0.4 1.8 1 0 0 1 1 1 0 TPR repeat Acyl-CoA_dh_1 PF00441.19 EFE40373.1 - 2.1e-31 109.0 2.0 3.8e-31 108.2 1.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFE40373.1 - 4.6e-16 58.0 0.0 1e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFE40373.1 - 1.1e-15 58.0 4.6 2.1e-15 57.1 3.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EFE40373.1 - 7.5e-14 52.2 0.3 1.8e-13 51.0 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain IGPD PF00475.13 EFE40374.1 - 8.7e-60 200.7 1.2 1.3e-59 200.1 0.8 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Spo12 PF05032.7 EFE40375.1 - 1.6e-14 53.2 0.6 3.4e-14 52.1 0.4 1.6 1 0 0 1 1 1 1 Spo12 family HlyD_2 PF12700.2 EFE40375.1 - 0.047 12.8 0.2 0.047 12.8 0.2 1.0 1 0 0 1 1 1 0 HlyD family secretion protein Sad1_UNC PF07738.8 EFE40376.1 - 3.7e-34 117.4 0.0 6.5e-34 116.6 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Pkinase PF00069.20 EFE40378.1 - 1.5e-55 188.1 0.0 2.3e-55 187.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40378.1 - 6.5e-33 113.8 0.0 9.2e-33 113.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE40378.1 - 2.7e-10 39.6 0.0 5.5e-08 32.1 0.0 2.4 2 0 0 2 2 2 2 Kinase-like SKG6 PF08693.5 EFE40379.1 - 0.39 10.0 4.1 1.3 8.4 2.9 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pep3_Vps18 PF05131.9 EFE40382.1 - 1e-46 158.0 0.0 2.6e-46 156.7 0.0 1.7 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.15 EFE40382.1 - 2.1e-11 43.6 1.4 9.9e-06 25.2 0.0 3.5 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-RING_2 PF13639.1 EFE40382.1 - 0.00049 19.8 0.7 0.0011 18.7 0.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EFE40382.1 - 0.0017 18.0 0.8 0.0041 16.8 0.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain DUF2175 PF09943.4 EFE40382.1 - 0.034 14.2 1.3 0.098 12.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Vps39_2 PF10367.4 EFE40382.1 - 0.081 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.1 EFE40382.1 - 0.29 11.2 1.1 0.67 10.0 0.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE40382.1 - 0.3 10.7 3.0 0.12 12.0 0.2 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1469 PF07332.6 EFE40383.1 - 0.00061 19.5 4.0 0.00061 19.5 2.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1469) RskA PF10099.4 EFE40383.1 - 0.1 12.2 8.2 0.15 11.7 5.7 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4259 PF14078.1 EFE40383.1 - 0.46 10.9 4.6 0.93 9.9 3.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4259) SNF2_N PF00176.18 EFE40384.1 - 4.7e-71 239.0 3.9 1e-70 237.9 2.7 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.1 EFE40384.1 - 1.7e-42 144.7 16.3 1.7e-42 144.7 11.3 5.0 4 1 1 5 5 5 1 DNA-binding domain Helicase_C PF00271.26 EFE40384.1 - 7.7e-16 57.7 0.0 2.2e-15 56.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Na_H_Exchanger PF00999.16 EFE40385.1 - 1.3e-58 198.4 35.9 8.7e-58 195.6 24.9 2.0 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family TYA PF01021.14 EFE40385.1 - 0.021 15.0 0.6 0.038 14.1 0.4 1.3 1 0 0 1 1 1 0 TYA transposon protein PepSY_TM_2 PF13703.1 EFE40385.1 - 0.035 14.2 2.8 0.47 10.6 0.2 3.5 2 1 0 2 2 2 0 PepSY-associated TM helix MFS_2 PF13347.1 EFE40387.1 - 3.2e-05 22.5 8.3 5.8e-05 21.6 1.7 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein STE PF02200.11 EFE40389.1 - 3.8e-62 207.2 0.3 7.1e-62 206.4 0.1 1.6 2 0 0 2 2 2 1 STE like transcription factor zf-C2H2 PF00096.21 EFE40389.1 - 0.00042 20.5 3.2 0.0013 18.9 2.2 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE40389.1 - 0.0011 19.1 2.4 0.003 17.7 1.7 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger DUF4602 PF15375.1 EFE40390.1 - 0.00054 20.0 7.4 0.00054 20.0 5.2 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4602) HHV6-IE PF03753.8 EFE40390.1 - 0.29 8.5 2.2 0.37 8.2 1.5 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein His_biosynth PF00977.16 EFE40391.1 - 3.7e-28 98.3 0.0 7.2e-14 51.6 0.0 2.0 2 0 0 2 2 2 2 Histidine biosynthesis protein Ribul_P_3_epim PF00834.14 EFE40391.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Radical_SAM PF04055.16 EFE40392.1 - 4.2e-16 59.5 0.0 1.2e-15 58.0 0.0 1.8 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 EFE40392.1 - 5.6e-12 45.5 0.0 1.4e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Ligase_CoA PF00549.14 EFE40393.1 - 1.2e-22 80.1 0.3 2e-22 79.4 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.14 EFE40393.1 - 4.6e-12 46.2 2.4 5.1e-11 42.9 0.3 2.4 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.1 EFE40393.1 - 7.5e-08 32.0 0.1 1.5e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain Ribosomal_L5_C PF00673.16 EFE40394.1 - 1.7e-23 82.1 0.0 3.8e-23 81.0 0.0 1.6 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Pkinase PF00069.20 EFE40395.1 - 2.9e-66 223.2 0.0 5.3e-66 222.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40395.1 - 4.4e-48 163.6 0.0 9.6e-48 162.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 EFE40395.1 - 1.9e-31 108.1 0.0 6.5e-31 106.3 0.0 1.9 2 0 0 2 2 2 1 Ras-binding domain of Byr2 Kinase-like PF14531.1 EFE40395.1 - 1e-07 31.2 0.0 0.00027 20.0 0.0 2.4 2 0 0 2 2 2 2 Kinase-like SAM_1 PF00536.25 EFE40395.1 - 7.1e-06 26.1 0.0 1.7e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 EFE40395.1 - 0.00032 21.1 0.0 0.00066 20.1 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_2 PF07647.12 EFE40395.1 - 0.0086 15.9 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kdo PF06293.9 EFE40395.1 - 0.032 13.2 0.0 0.059 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 EFE40395.1 - 0.16 10.7 0.1 0.76 8.5 0.0 2.1 3 0 0 3 3 3 0 Seadornavirus VP7 FAM176 PF14851.1 EFE40396.1 - 0.0057 16.3 0.2 0.012 15.3 0.1 1.4 1 0 0 1 1 1 1 FAM176 family PBP1_TM PF14812.1 EFE40396.1 - 0.015 15.5 7.2 0.029 14.6 5.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BSP_II PF05432.6 EFE40396.1 - 0.018 14.3 1.9 0.031 13.5 1.3 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nop14 PF04147.7 EFE40396.1 - 0.099 10.5 0.6 0.14 10.0 0.4 1.1 1 0 0 1 1 1 0 Nop14-like family Nucleoplasmin PF03066.10 EFE40396.1 - 0.23 10.9 8.5 0.41 10.1 5.9 1.3 1 0 0 1 1 1 0 Nucleoplasmin CENP-B_dimeris PF09026.5 EFE40396.1 - 0.42 10.8 9.8 1 9.6 6.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.6 EFE40396.1 - 0.56 7.9 15.9 0.0095 13.8 5.9 1.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Sigma70_ner PF04546.8 EFE40396.1 - 2.7 7.5 6.7 5.8 6.4 4.6 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region RXT2_N PF08595.6 EFE40396.1 - 3.1 7.6 4.8 6.8 6.4 3.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal MMR_HSR1 PF01926.18 EFE40397.1 - 4.3e-17 62.1 0.3 8.5e-15 54.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE40397.1 - 5.1e-06 25.8 0.5 8.5e-05 21.8 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 EFE40397.1 - 0.0011 18.1 0.0 0.0022 17.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 EFE40397.1 - 0.0015 17.6 0.1 0.003 16.6 0.1 1.4 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 EFE40397.1 - 0.063 13.7 0.0 0.23 11.9 0.0 2.0 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 EFE40397.1 - 0.31 10.8 7.6 0.26 11.1 0.3 3.3 3 1 1 4 4 4 0 Dynamin family Ribosomal_60s PF00428.14 EFE40397.1 - 1.1 9.6 10.4 1.3 9.4 6.2 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein LTV PF04180.9 EFE40398.1 - 1.5e-56 192.6 14.3 2.2e-56 192.2 9.9 1.1 1 0 0 1 1 1 1 Low temperature viability protein PLDc_2 PF13091.1 EFE40399.1 - 2.7e-09 36.8 0.0 0.00024 20.8 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 EFE40399.1 - 3.4e-09 36.1 2.4 0.0058 16.4 0.3 3.3 2 1 0 2 2 2 2 Phospholipase D Active site motif Methyltransf_11 PF08241.7 EFE40400.1 - 4.5e-26 91.1 0.0 1.3e-11 44.8 0.0 3.4 3 0 0 3 3 2 2 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40400.1 - 4e-19 68.8 0.0 4.5e-11 42.7 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.1 EFE40400.1 - 4.2e-19 68.6 0.0 2.8e-11 43.2 0.0 3.0 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFE40400.1 - 1.8e-17 63.9 0.0 7.3e-10 39.4 0.0 3.2 3 0 0 3 3 2 2 Methyltransferase domain Methyltransf_25 PF13649.1 EFE40400.1 - 9.6e-17 61.2 0.0 1.1e-10 41.7 0.0 3.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40400.1 - 5e-12 46.1 0.0 6.2e-07 29.8 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_26 PF13659.1 EFE40400.1 - 1.8e-09 37.6 0.0 0.0034 17.3 0.0 3.7 4 0 0 4 4 3 2 Methyltransferase domain CMAS PF02353.15 EFE40400.1 - 1.3e-08 34.2 0.0 9.2e-08 31.4 0.0 2.0 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase TPR_2 PF07719.12 EFE40400.1 - 3e-08 32.9 1.7 0.07 13.0 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat MetW PF07021.7 EFE40400.1 - 4.6e-08 32.6 0.0 0.0011 18.3 0.0 2.4 2 0 0 2 2 2 2 Methionine biosynthesis protein MetW TPR_11 PF13414.1 EFE40400.1 - 5.7e-08 32.2 3.4 0.00042 19.9 0.0 4.8 4 0 0 4 4 4 1 TPR repeat Ubie_methyltran PF01209.13 EFE40400.1 - 7.8e-08 31.7 0.0 0.00024 20.2 0.0 2.4 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family TPR_8 PF13181.1 EFE40400.1 - 8.5e-08 31.4 5.1 6e-05 22.5 0.0 5.6 7 0 0 7 7 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFE40400.1 - 8.7e-07 29.1 4.1 0.13 12.6 0.0 4.4 4 0 0 4 4 3 2 Tetratricopeptide repeat NodS PF05401.6 EFE40400.1 - 4.2e-06 26.2 0.0 0.00073 18.9 0.0 2.4 2 0 0 2 2 2 1 Nodulation protein S (NodS) TPR_14 PF13428.1 EFE40400.1 - 4.6e-06 26.7 9.8 0.46 11.2 0.0 7.1 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFE40400.1 - 1e-05 25.3 0.1 0.34 11.2 0.0 4.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE40400.1 - 2e-05 25.1 14.9 3 8.6 0.0 6.7 6 0 0 6 6 5 1 Tetratricopeptide repeat GidB PF02527.10 EFE40400.1 - 5.7e-05 22.3 0.0 0.011 14.8 0.0 2.3 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G MTS PF05175.9 EFE40400.1 - 7.2e-05 22.2 0.0 0.00059 19.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain TPR_1 PF00515.23 EFE40400.1 - 0.0014 18.1 3.8 0.025 14.1 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TehB PF03848.9 EFE40400.1 - 0.0014 17.8 0.0 0.0062 15.7 0.0 1.9 2 0 0 2 2 2 1 Tellurite resistance protein TehB NNMT_PNMT_TEMT PF01234.12 EFE40400.1 - 0.012 14.5 0.0 0.12 11.2 0.0 2.4 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family TPR_20 PF14561.1 EFE40400.1 - 0.025 14.6 2.4 4.6 7.4 0.0 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat Spermine_synth PF01564.12 EFE40400.1 - 0.035 13.0 0.0 0.075 11.9 0.0 1.5 1 0 0 1 1 1 0 Spermine/spermidine synthase CheR PF01739.13 EFE40400.1 - 0.11 11.8 0.0 2.1 7.6 0.0 2.5 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain RrnaAD PF00398.15 EFE40400.1 - 0.11 11.5 0.0 0.66 8.9 0.0 2.1 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase PCMT PF01135.14 EFE40400.1 - 0.22 11.0 0.0 3 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pox_MCEL PF03291.11 EFE40400.1 - 0.3 9.9 0.0 0.53 9.1 0.0 1.3 1 0 0 1 1 1 0 mRNA capping enzyme DUF3287 PF11690.3 EFE40401.1 - 0.038 14.0 0.0 0.052 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Phasin_2 PF09361.5 EFE40401.1 - 0.057 13.4 0.6 0.082 12.9 0.4 1.4 1 1 0 1 1 1 0 Phasin protein Methyltransf_2 PF00891.13 EFE40402.1 - 2.3e-25 89.2 0.0 3.4e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase p450 PF00067.17 EFE40402.1 - 2.2e-08 33.0 0.1 6e-08 31.6 0.0 1.6 2 0 0 2 2 2 1 Cytochrome P450 Methyltransf_18 PF12847.2 EFE40402.1 - 0.0017 18.9 0.0 0.0043 17.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE40402.1 - 0.0025 18.1 0.0 0.0066 16.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40402.1 - 0.028 14.1 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_3 PF09069.6 EFE40402.1 - 0.038 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 EF-hand p450 PF00067.17 EFE40403.1 - 2.3e-19 69.2 0.0 4e-19 68.4 0.0 1.3 2 0 0 2 2 2 1 Cytochrome P450 RIX1 PF08167.7 EFE40404.1 - 5.8e-23 81.3 0.1 7.2e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis Terminase_6 PF03237.10 EFE40404.1 - 0.048 12.4 0.0 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 Terminase-like family MBOAT_2 PF13813.1 EFE40406.1 - 2.7e-19 68.9 1.7 6e-19 67.9 1.2 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Big_4 PF07532.6 EFE40406.1 - 0.17 11.4 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) SNF2_N PF00176.18 EFE40407.1 - 8.9e-73 244.6 0.1 2.1e-72 243.4 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain HIRAN PF08797.6 EFE40407.1 - 3.4e-13 49.4 0.0 6.5e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.26 EFE40407.1 - 1.6e-11 43.8 0.0 5.4e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 EFE40407.1 - 3.3e-10 39.6 6.6 3.3e-10 39.6 4.5 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFE40407.1 - 2.2e-08 33.9 7.2 2.2e-08 33.9 5.0 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE40407.1 - 1.7e-07 30.7 7.4 1.7e-07 30.7 5.1 2.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE40407.1 - 8.3e-07 28.5 8.1 2.5e-06 27.0 5.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFE40407.1 - 1.2e-06 28.5 1.5 4.7e-06 26.6 1.1 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EFE40407.1 - 1.8e-05 24.3 5.1 1.8e-05 24.3 3.5 2.0 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EFE40407.1 - 0.00031 20.5 8.5 0.00073 19.3 5.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 EFE40407.1 - 0.002 17.5 3.9 0.021 14.3 3.1 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit HDA2-3 PF11496.3 EFE40407.1 - 0.0042 15.9 0.1 0.3 9.8 0.0 2.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 U-box PF04564.10 EFE40407.1 - 0.014 15.3 0.1 0.06 13.3 0.0 2.1 2 0 0 2 2 1 0 U-box domain zf-RING_UBOX PF13445.1 EFE40407.1 - 0.029 14.0 5.4 0.1 12.3 3.8 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-Apc11 PF12861.2 EFE40407.1 - 0.13 12.1 1.8 0.49 10.2 1.3 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger SNF2_N PF00176.18 EFE40408.1 - 5.1e-50 169.9 0.1 1e-49 168.9 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE40408.1 - 1.3e-13 50.5 0.0 3.3e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE40408.1 - 0.00052 19.8 0.0 0.0017 18.2 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SAM_1 PF00536.25 EFE40408.1 - 0.049 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 EFE40408.1 - 0.067 13.0 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) AAA_34 PF13872.1 EFE40408.1 - 0.2 10.4 0.0 0.47 9.1 0.0 1.6 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 GSH_synth_ATP PF03917.12 EFE40409.1 - 6.1e-99 331.0 0.0 7.5e-99 330.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 EFE40409.1 - 4.6e-29 100.6 0.0 8.9e-29 99.6 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Bestrophin PF01062.16 EFE40413.1 - 5.5e-28 97.7 0.0 6.6e-27 94.2 0.0 2.0 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Aminotran_3 PF00202.16 EFE40415.1 - 4.2e-102 341.4 0.0 4.9e-102 341.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EFE40415.1 - 0.0076 15.2 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Metallophos PF00149.23 EFE40416.1 - 9.7e-37 126.3 0.0 1.3e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 EFE40416.1 - 2.1e-30 104.5 0.7 4.7e-30 103.4 0.5 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_11 PF13414.1 EFE40416.1 - 4.4e-21 74.2 3.5 4.2e-17 61.5 0.6 2.8 1 1 2 3 3 3 2 TPR repeat TPR_1 PF00515.23 EFE40416.1 - 3.4e-11 42.2 4.4 0.0001 21.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFE40416.1 - 2e-09 36.6 4.0 0.0041 16.9 0.3 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE40416.1 - 5.6e-06 26.8 1.8 0.17 12.6 0.1 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFE40416.1 - 8.7e-06 25.5 0.1 0.0062 16.3 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFE40416.1 - 0.0017 18.6 0.5 2.8 8.3 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 EFE40416.1 - 0.0033 17.7 0.7 8.3 7.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE40416.1 - 0.0035 17.2 0.5 0.012 15.5 0.2 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFE40416.1 - 0.0051 16.9 0.8 11 6.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFE40416.1 - 0.017 15.6 1.4 15 6.5 0.0 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 EFE40416.1 - 0.024 14.4 2.0 2.2 8.2 0.1 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 EFE40416.1 - 0.034 13.9 0.3 0.61 10.0 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF89 PF01937.14 EFE40417.1 - 1.1e-105 353.3 0.1 1.2e-105 353.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 CENP-F_leu_zip PF10473.4 EFE40417.1 - 0.0051 16.6 0.1 0.023 14.5 0.1 2.0 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cut12 PF11500.3 EFE40418.1 - 5.1e-46 156.1 14.5 5.1e-46 156.1 10.1 4.2 2 1 0 3 3 3 1 Spindle pole body formation-associated protein HGTP_anticodon2 PF12745.2 EFE40419.1 - 2.7e-84 282.5 1.9 5.8e-84 281.4 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.20 EFE40419.1 - 3.1e-65 219.9 0.0 1.2e-36 126.1 0.0 3.8 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40419.1 - 8.4e-37 126.6 0.0 4.4e-19 68.5 0.0 3.7 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.17 EFE40419.1 - 1.1e-16 60.7 0.4 3.8e-16 58.9 0.3 2.0 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.1 EFE40419.1 - 2.5e-08 33.3 1.7 1.5e-06 27.4 0.0 3.0 2 1 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.18 EFE40419.1 - 0.0087 15.8 0.1 0.0087 15.8 0.1 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family RRM_1 PF00076.17 EFE40420.1 - 2.7e-08 33.3 0.0 5.2e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE40420.1 - 4.8e-07 29.5 0.0 9.3e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40420.1 - 0.00053 19.9 0.0 0.0009 19.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE40420.1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Ifi-6-16 PF06140.8 EFE40420.1 - 0.0031 17.2 1.5 0.0058 16.3 1.0 1.4 1 0 0 1 1 1 1 Interferon-induced 6-16 family zf-CCCH PF00642.19 EFE40420.1 - 0.044 13.4 1.7 0.079 12.6 1.1 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MMR_HSR1 PF01926.18 EFE40421.1 - 2.6e-19 69.2 0.0 4.1e-19 68.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE40421.1 - 7.9e-13 47.9 0.0 1.2e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EFE40421.1 - 1.4e-05 25.0 0.3 0.015 15.0 0.0 2.2 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 EFE40421.1 - 0.00079 19.9 0.0 0.0018 18.7 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein ArgK PF03308.11 EFE40421.1 - 0.046 12.4 0.1 0.089 11.5 0.1 1.5 1 0 0 1 1 1 0 ArgK protein AIG1 PF04548.11 EFE40421.1 - 0.05 12.7 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 AIG1 family MCM PF00493.18 EFE40421.1 - 0.097 11.4 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family DnaJ PF00226.26 EFE40422.1 - 2.5e-24 84.8 1.4 6e-24 83.5 1.0 1.7 1 1 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EFE40422.1 - 8.3e-23 80.0 0.6 2.1e-20 72.4 0.0 2.4 2 0 0 2 2 2 2 DnaJ C terminal domain PIG-X PF08320.7 EFE40423.1 - 8.3e-69 231.0 0.0 1.2e-68 230.5 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 RFX_DNA_binding PF02257.10 EFE40424.1 - 5.1e-29 100.2 0.1 1.5e-28 98.7 0.1 1.8 1 0 0 1 1 1 1 RFX DNA-binding domain TB2_DP1_HVA22 PF03134.14 EFE40425.1 - 8.7e-22 76.6 9.8 3.7e-16 58.6 6.2 2.3 2 0 0 2 2 2 2 TB2/DP1, HVA22 family Thy1 PF02511.10 EFE40425.1 - 0.083 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Thymidylate synthase complementing protein DUF1649 PF07855.7 EFE40426.1 - 2.5e-63 212.5 0.0 2.9e-63 212.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1649) DUF2922 PF11148.3 EFE40426.1 - 0.007 15.9 0.1 0.014 15.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) Peroxin-3 PF04882.7 EFE40427.1 - 1.6e-141 471.9 0.0 1.9e-141 471.7 0.0 1.0 1 0 0 1 1 1 1 Peroxin-3 Na_H_Exchanger PF00999.16 EFE40428.1 - 1.7e-68 230.9 44.9 2.4e-68 230.4 31.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family MFS_1 PF07690.11 EFE40429.1 - 3e-35 121.5 28.2 3e-35 121.5 19.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3147 PF11345.3 EFE40429.1 - 0.11 12.4 7.1 0.35 10.8 1.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3147) Mito_fiss_reg PF05308.6 EFE40430.1 - 0.24 10.7 15.3 0.44 9.8 10.1 1.8 1 1 0 1 1 1 0 Mitochondrial fission regulator ThiF PF00899.16 EFE40431.1 - 3.7e-17 62.4 0.0 6.1e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 ThiF family DUF2267 PF10025.4 EFE40431.1 - 0.086 12.9 0.3 2.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) Ytp1 PF10355.4 EFE40432.1 - 3.7e-85 285.4 13.6 3.7e-85 285.4 9.5 1.4 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EFE40432.1 - 1.4e-09 37.4 2.8 1.4e-09 37.4 1.9 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) DUF3815 PF12821.2 EFE40432.1 - 0.028 14.3 0.0 0.028 14.3 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3815) DUF973 PF06157.6 EFE40432.1 - 0.038 12.9 5.5 0.08 11.8 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Filament PF00038.16 EFE40433.1 - 0.0097 15.4 7.1 0.021 14.3 4.9 1.5 1 0 0 1 1 1 1 Intermediate filament protein CALCOCO1 PF07888.6 EFE40433.1 - 0.012 13.9 6.9 0.025 12.8 4.8 1.5 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Polysacc_deac_2 PF04748.8 EFE40433.1 - 0.019 13.9 0.5 0.037 13.0 0.4 1.4 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Herpes_UL25 PF01499.11 EFE40433.1 - 0.18 10.0 5.0 0.31 9.3 3.4 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family DUF342 PF03961.8 EFE40433.1 - 0.21 9.9 3.9 0.33 9.3 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Cauli_AT PF03233.8 EFE40433.1 - 0.49 10.0 5.3 0.36 10.5 1.5 2.2 2 0 0 2 2 2 0 Aphid transmission protein IncA PF04156.9 EFE40433.1 - 0.58 9.7 10.8 0.45 10.0 6.2 1.8 2 0 0 2 2 2 0 IncA protein LcrG PF07216.7 EFE40433.1 - 0.63 10.1 4.9 1.8 8.6 3.4 1.7 1 0 0 1 1 1 0 LcrG protein DUF479 PF04336.7 EFE40433.1 - 0.74 9.9 3.2 1.5 9.0 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF479 DUF4407 PF14362.1 EFE40433.1 - 1.5 7.7 7.0 3.1 6.6 4.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2570 PF10828.3 EFE40433.1 - 5.9 6.5 9.2 7.4 6.2 5.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Glycos_transf_2 PF00535.21 EFE40434.1 - 3.4e-21 75.6 0.0 8.2e-18 64.6 0.0 2.9 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EFE40434.1 - 0.00015 21.6 0.0 1.3 8.7 0.0 3.2 3 1 0 3 3 3 2 Glycosyltransferase like family 2 Dicty_CAR PF05462.6 EFE40435.1 - 1.5e-11 43.7 8.4 2.2e-11 43.2 5.8 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.19 EFE40435.1 - 3.4e-07 29.5 9.2 6e-07 28.7 6.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Git3 PF11710.3 EFE40435.1 - 2e-05 24.2 8.3 3.2e-05 23.5 5.7 1.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 EFE40435.1 - 6.4e-05 22.2 0.0 7.6e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.4 EFE40435.1 - 0.0002 20.6 2.1 0.00029 20.0 1.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Frizzled PF01534.12 EFE40435.1 - 4.1 6.0 12.7 81 1.8 8.8 2.2 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region Cyclin PF08613.6 EFE40436.1 - 1.5e-35 122.7 1.3 1.1e-21 77.8 0.3 3.8 4 2 1 5 5 5 2 Cyclin DUF3306 PF11748.3 EFE40436.1 - 0.13 12.9 0.3 0.13 12.9 0.2 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3306) Spt20 PF12090.3 EFE40436.1 - 3.1 7.1 11.8 3.8 6.8 0.5 2.9 3 0 0 3 3 3 0 Spt20 family RAB3GAP2_N PF14655.1 EFE40436.1 - 3.5 6.5 13.1 0.51 9.2 1.4 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RabGAP-TBC PF00566.13 EFE40437.1 - 5.7e-28 97.8 0.0 8e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3535 PF12054.3 EFE40438.1 - 0.14 10.7 1.7 0.23 10.0 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) Telomerase_RBD PF12009.3 EFE40440.1 - 1.2e-39 135.3 0.0 3.2e-39 133.9 0.0 1.8 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 EFE40440.1 - 2.2e-14 53.3 0.0 1.8e-13 50.3 0.0 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RhoGEF PF00621.15 EFE40441.1 - 7.2e-38 130.2 0.0 2.4e-37 128.5 0.0 2.0 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.13 EFE40441.1 - 3.7e-13 49.5 0.8 1.9e-12 47.2 0.5 2.3 1 1 0 1 1 1 1 BAR domain Multi_Drug_Res PF00893.14 EFE40441.1 - 3.3 8.2 4.8 6.4 7.3 3.3 1.4 1 0 0 1 1 1 0 Small Multidrug Resistance protein Peptidase_C48 PF02902.14 EFE40442.1 - 1.3e-13 51.0 0.6 7.8e-13 48.5 0.4 2.2 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Consortin_C PF15281.1 EFE40442.1 - 0.072 12.5 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Consortin C-terminus DUF1652 PF07865.6 EFE40442.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1652) PrpF PF04303.8 EFE40443.1 - 2.2e-106 355.7 0.2 2.5e-106 355.5 0.1 1.0 1 0 0 1 1 1 1 PrpF protein tRNA-synt_1d PF00750.14 EFE40444.1 - 7.8e-75 251.8 0.4 2.1e-74 250.4 0.3 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 EFE40444.1 - 2.3e-23 82.4 0.9 7e-23 80.8 0.1 2.1 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 EFE40444.1 - 0.033 14.7 0.1 0.11 13.0 0.0 2.0 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain OGFr_III PF04680.8 EFE40445.1 - 0.025 14.6 0.2 0.025 14.6 0.1 2.3 3 0 0 3 3 3 0 Opioid growth factor receptor repeat DAP3 PF10236.4 EFE40446.1 - 1.1e-82 277.5 0.0 1.7e-82 276.8 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.4 EFE40446.1 - 0.093 11.6 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RRS1 PF04939.7 EFE40447.1 - 4.8e-57 192.0 2.7 5.6e-57 191.7 1.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DUF883 PF05957.8 EFE40449.1 - 0.47 10.8 8.2 1.5 9.2 5.5 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) ATP-synt_B PF00430.13 EFE40449.1 - 2.9 7.6 9.8 3.8 7.3 5.7 1.9 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Ran_BP1 PF00638.13 EFE40450.1 - 2e-52 176.4 1.5 3e-52 175.8 1.0 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 EFE40450.1 - 0.0017 18.0 0.4 0.011 15.5 0.3 2.0 1 1 0 1 1 1 1 WH1 domain TMEM247 PF15444.1 EFE40450.1 - 7.8 6.2 7.8 10 5.8 5.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 eIF-3c_N PF05470.7 EFE40450.1 - 8.1 4.3 11.2 11 4.0 7.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus YEATS PF03366.11 EFE40451.1 - 7.3e-11 41.6 0.0 1.4e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 YEATS family Phosducin PF02114.11 EFE40452.1 - 7.4e-15 54.3 0.0 3e-14 52.3 0.0 1.9 1 1 0 1 1 1 1 Phosducin 2-Hacid_dh_C PF02826.14 EFE40455.1 - 1.9e-52 177.0 0.0 2.6e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFE40455.1 - 9.2e-17 60.7 0.0 1.7e-16 59.8 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFE40455.1 - 3.5e-08 33.4 0.0 6.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 EFE40455.1 - 0.0015 18.9 0.0 0.0045 17.3 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.16 EFE40455.1 - 0.034 13.7 0.0 0.16 11.5 0.0 1.8 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.11 EFE40455.1 - 0.05 13.0 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA WD40 PF00400.27 EFE40456.1 - 1.4e-51 170.5 21.7 1.7e-09 37.1 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 EFE40456.1 - 0.00014 21.6 0.0 0.1 12.2 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 EFE40456.1 - 0.12 10.6 0.0 1.2 7.3 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain EphA2_TM PF14575.1 EFE40458.1 - 0.12 12.7 0.4 0.31 11.4 0.2 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Conotoxin PF02950.12 EFE40458.1 - 0.14 12.9 1.7 0.18 12.6 0.1 2.2 2 0 0 2 2 2 0 Conotoxin DUF4234 PF14018.1 EFE40458.1 - 0.26 11.0 1.7 0.33 10.7 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4234) DUF3789 PF12664.2 EFE40458.1 - 0.31 10.3 0.0 0.31 10.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3789) AgrB PF04647.10 EFE40458.1 - 2.3 7.2 10.2 0.24 10.4 1.6 2.3 1 1 2 3 3 3 0 Accessory gene regulator B DUF3357 PF11837.3 EFE40458.1 - 6.1 6.7 7.5 1.2 9.0 0.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Adeno_terminal PF02459.10 EFE40459.1 - 0.73 7.9 5.4 0.84 7.7 3.8 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DUF3402 PF11882.3 EFE40459.1 - 1.4 7.8 5.8 1.5 7.8 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) CP2 PF04516.10 EFE40461.1 - 6.8e-81 270.8 0.1 1.2e-80 270.0 0.1 1.4 1 0 0 1 1 1 1 CP2 transcription factor Pkinase PF00069.20 EFE40463.1 - 2e-05 23.8 0.0 3.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFE40463.1 - 3.9e-05 23.4 0.1 0.00012 21.8 0.1 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 EFE40463.1 - 0.0025 16.9 0.0 0.0063 15.6 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE40463.1 - 0.003 16.6 0.0 0.0066 15.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE40463.1 - 0.038 13.5 0.0 0.081 12.4 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF3962 PF13111.1 EFE40464.1 - 0.047 13.0 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3962) TFIIS_M PF07500.9 EFE40467.1 - 1.5e-28 99.1 1.0 1.5e-28 99.1 0.7 1.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 EFE40467.1 - 1.2e-18 66.4 4.5 1.9e-18 65.8 3.2 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 EFE40467.1 - 6.3e-15 54.4 0.4 1.4e-14 53.3 0.3 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Baculo_LEF5_C PF11792.3 EFE40467.1 - 0.026 13.9 1.3 0.063 12.6 0.9 1.7 1 1 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain Chordopox_A33R PF05966.7 EFE40467.1 - 0.036 12.8 0.0 0.08 11.7 0.0 1.7 1 0 0 1 1 1 0 Chordopoxvirus A33R protein Cytochrome_C554 PF13435.1 EFE40467.1 - 0.076 13.0 1.7 0.25 11.4 1.2 1.8 1 0 0 1 1 1 0 Cytochrome c554 and c-prime Sec10 PF07393.6 EFE40469.1 - 3.3e-235 782.5 0.0 3.9e-235 782.3 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 MBOAT_2 PF13813.1 EFE40470.1 - 8e-17 61.1 0.2 2.3e-16 59.6 0.1 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family LRR_6 PF13516.1 EFE40471.1 - 7.2e-12 44.0 4.1 0.17 12.0 0.0 7.9 8 0 0 8 8 8 2 Leucine Rich repeat LRR_4 PF12799.2 EFE40471.1 - 1.6e-07 30.7 5.0 0.47 10.1 0.5 5.2 4 2 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EFE40471.1 - 2.7e-05 23.6 6.9 38 4.8 0.0 7.4 8 1 1 9 9 9 0 Leucine Rich Repeat LRR_8 PF13855.1 EFE40471.1 - 0.0021 17.7 4.0 2.2 8.0 0.0 5.1 4 2 3 7 7 7 2 Leucine rich repeat LRR_7 PF13504.1 EFE40471.1 - 0.085 13.1 4.9 3.2e+02 2.3 0.0 6.5 8 0 0 8 8 8 0 Leucine rich repeat Nop14 PF04147.7 EFE40471.1 - 0.72 7.6 26.3 0.9 7.3 18.2 1.1 1 0 0 1 1 1 0 Nop14-like family PRTP PF01366.13 EFE40471.1 - 0.87 7.4 7.5 1.2 6.9 5.2 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Daxx PF03344.10 EFE40471.1 - 3.8 5.8 23.1 5.1 5.4 16.0 1.2 1 0 0 1 1 1 0 Daxx Family Sigma70_ner PF04546.8 EFE40471.1 - 9.8 5.7 22.6 31 4.0 15.1 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region Alg6_Alg8 PF03155.10 EFE40472.1 - 1.7e-129 432.7 17.2 1.1e-80 271.7 2.8 2.0 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family EpsG PF14897.1 EFE40472.1 - 0.27 10.1 8.6 0.076 11.9 3.5 1.8 1 1 1 2 2 2 0 EpsG family RRM_1 PF00076.17 EFE40473.1 - 1.1e-31 108.3 0.1 2.4e-19 68.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40473.1 - 2.3e-29 101.1 0.0 1.3e-18 66.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE40473.1 - 6.3e-19 67.5 0.0 5.2e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 EFE40473.1 - 0.0036 15.8 54.0 0.0048 15.4 37.4 1.3 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Utp14 PF04615.8 EFE40473.1 - 6.6 4.7 63.6 11 4.0 44.1 1.2 1 0 0 1 1 1 0 Utp14 protein Herpes_pp38 PF04846.8 EFE40474.1 - 0.073 12.3 0.1 0.14 11.4 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein DUF591 PF04569.9 EFE40475.1 - 2.5 8.1 9.6 5.1 7.2 6.7 1.7 1 1 0 1 1 1 0 Protein of unknown function NMT1 PF09084.6 EFE40476.1 - 9.2e-78 260.7 0.0 1.2e-77 260.3 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 EFE40476.1 - 1.6e-09 37.5 0.1 0.0034 16.7 0.0 3.2 3 0 0 3 3 3 3 NMT1-like family Ribosomal_L37 PF08561.5 EFE40477.1 - 3.6e-28 96.9 6.1 6.5e-27 92.9 4.3 2.3 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 Spectrin PF00435.16 EFE40477.1 - 0.045 14.0 0.2 0.068 13.4 0.2 1.3 1 0 0 1 1 1 0 Spectrin repeat P12 PF12669.2 EFE40478.1 - 0.059 13.5 0.3 0.059 13.5 0.2 1.6 2 0 0 2 2 2 0 Virus attachment protein p12 family Cpn60_TCP1 PF00118.19 EFE40479.1 - 3.5e-118 395.2 9.8 4.3e-118 394.9 6.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3924 PF13062.1 EFE40479.1 - 0.083 12.7 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3924) AAA PF00004.24 EFE40480.1 - 4.7e-41 140.0 0.0 8.2e-41 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE40480.1 - 5e-06 26.6 0.0 0.00059 19.9 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFE40480.1 - 4.5e-05 23.1 0.1 0.00026 20.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFE40480.1 - 0.00018 21.5 0.0 0.00059 19.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EFE40480.1 - 0.0002 21.4 0.0 0.00082 19.4 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 EFE40480.1 - 0.0025 16.7 0.0 0.0045 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 EFE40480.1 - 0.0032 18.2 0.1 0.013 16.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFE40480.1 - 0.009 15.0 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFE40480.1 - 0.0098 15.6 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 EFE40480.1 - 0.017 15.1 0.1 0.045 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 EFE40480.1 - 0.025 14.4 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFE40480.1 - 0.036 13.9 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFE40480.1 - 0.051 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.1 EFE40480.1 - 0.055 13.0 0.1 0.65 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.6 EFE40480.1 - 0.065 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 EFE40480.1 - 0.077 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 EFE40480.1 - 0.079 12.0 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.12 EFE40480.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein FAD_binding_2 PF00890.19 EFE40481.1 - 3.3e-125 418.1 3.5 4.2e-125 417.8 2.4 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 EFE40481.1 - 2.9e-47 159.7 1.3 4.2e-47 159.1 0.9 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 EFE40481.1 - 2.6e-06 27.4 0.0 0.0015 18.4 0.1 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFE40481.1 - 8.9e-06 24.8 1.0 0.011 14.5 1.4 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.12 EFE40481.1 - 1.4e-05 24.2 0.1 0.015 14.4 0.0 2.3 2 0 0 2 2 2 2 Thi4 family DAO PF01266.19 EFE40481.1 - 0.00036 19.5 1.0 0.0026 16.7 0.5 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFE40481.1 - 0.0052 15.8 0.5 0.011 14.8 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 EFE40481.1 - 0.27 9.6 1.7 0.83 8.0 0.6 2.2 2 0 0 2 2 2 0 HI0933-like protein DPPIV_N PF00930.16 EFE40482.1 - 1.3e-107 359.4 0.4 1.9e-107 358.9 0.3 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 EFE40482.1 - 2.3e-55 187.0 4.4 2.3e-55 187.0 3.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFE40482.1 - 1.4e-09 37.8 0.0 4e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family PBP1_TM PF14812.1 EFE40482.1 - 3e-06 27.4 0.0 7e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_S15 PF02129.13 EFE40482.1 - 3.1e-06 26.8 0.9 1.5e-05 24.5 0.4 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 EFE40482.1 - 9.6e-06 25.6 0.0 0.00016 21.6 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EFE40482.1 - 0.0012 18.3 0.5 0.0039 16.6 0.3 1.8 1 1 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.11 EFE40482.1 - 0.089 12.2 0.4 7.4 5.9 0.3 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase HNH_2 PF13391.1 EFE40483.1 - 3.1e-11 42.8 0.1 7.4e-11 41.6 0.1 1.7 1 0 0 1 1 1 1 HNH endonuclease Glyco_hydro_18 PF00704.23 EFE40484.1 - 8.3e-41 140.5 1.4 1.3e-40 139.9 1.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.15 EFE40484.1 - 1.3e-10 40.9 0.3 2.5e-06 27.2 0.1 2.6 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.14 EFE40484.1 - 0.00074 19.4 4.1 0.00074 19.4 2.9 3.6 4 0 0 4 4 4 1 Chitin recognition protein ATG11 PF10377.4 EFE40486.1 - 0.092 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Autophagy-related protein 11 HNH_2 PF13391.1 EFE40487.1 - 1.3e-10 40.9 0.0 3.4e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 HNH endonuclease Nucleoplasmin PF03066.10 EFE40487.1 - 2.3 7.7 11.4 5.3 6.5 7.9 1.6 1 0 0 1 1 1 0 Nucleoplasmin CoA_binding_3 PF13727.1 EFE40488.1 - 0.0055 16.5 0.9 0.028 14.2 0.5 2.2 2 0 0 2 2 2 1 CoA-binding domain Ldh_1_C PF02866.13 EFE40489.1 - 8.2e-44 149.3 0.0 1.2e-43 148.8 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 EFE40489.1 - 7.8e-39 132.7 0.0 1.3e-38 132.0 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EFE40489.1 - 0.0042 15.8 0.0 0.0062 15.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.11 EFE40489.1 - 0.045 13.0 0.1 0.19 11.0 0.2 1.9 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase AAA PF00004.24 EFE40490.1 - 1.2e-16 61.0 0.6 7.1e-16 58.6 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFE40490.1 - 1.6e-05 24.5 0.1 6.9e-05 22.5 0.1 2.1 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 EFE40490.1 - 0.00018 21.2 0.0 0.00062 19.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFE40490.1 - 0.00062 19.9 1.8 0.0057 16.7 0.1 2.7 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 EFE40490.1 - 0.0028 17.6 0.0 0.011 15.7 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 EFE40490.1 - 0.034 14.0 0.1 0.034 14.0 0.0 3.2 3 2 0 3 3 3 0 AAA domain AAA_11 PF13086.1 EFE40490.1 - 0.057 12.9 0.0 0.057 12.9 0.0 4.3 2 1 0 2 2 2 0 AAA domain TFIIF_alpha PF05793.7 EFE40490.1 - 10 4.3 64.3 0.038 12.3 36.7 2.5 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Myb_DNA-bind_6 PF13921.1 EFE40491.1 - 2.2e-05 24.4 0.4 0.012 15.7 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 EFE40491.1 - 0.00063 20.3 0.4 0.67 10.6 0.0 2.4 1 1 1 2 2 2 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 EFE40491.1 - 0.012 15.7 1.8 0.021 14.9 0.1 2.1 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 EFE40491.1 - 0.064 13.1 2.5 0.32 10.9 0.1 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Peptidase_S64 PF08192.6 EFE40492.1 - 9.1e-07 27.6 0.0 1.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S64 Trypsin_2 PF13365.1 EFE40492.1 - 0.0011 18.9 0.0 0.0023 17.9 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain HbrB PF08539.6 EFE40494.1 - 2e-53 180.4 0.0 3.2e-53 179.8 0.0 1.3 1 0 0 1 1 1 1 HbrB-like Ank_2 PF12796.2 EFE40495.1 - 1.8e-96 316.6 13.3 1.2e-21 76.8 0.1 6.3 1 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 EFE40495.1 - 2.3e-83 270.1 9.9 1.1e-06 28.1 0.0 14.3 14 0 0 14 14 14 13 Ankyrin repeat Ank_4 PF13637.1 EFE40495.1 - 9.8e-68 223.4 2.2 2.6e-12 46.8 0.0 9.0 7 2 2 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE40495.1 - 6.9e-61 200.9 6.2 7.8e-10 38.6 0.0 12.5 2 1 11 13 13 13 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE40495.1 - 1e-57 186.2 2.8 0.00071 19.5 0.0 13.5 13 0 0 13 13 13 11 Ankyrin repeat HNH_2 PF13391.1 EFE40496.1 - 1.1e-15 57.1 0.0 2e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease Gon7 PF08738.5 EFE40497.1 - 2.6e-15 56.2 1.5 7.6e-15 54.7 1.0 1.5 1 1 0 1 1 1 1 Gon7 family Vps39_1 PF10366.4 EFE40498.1 - 1.2e-29 102.4 0.0 1.1e-28 99.4 0.0 2.6 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.4 EFE40498.1 - 2.4e-23 82.3 0.0 1.9e-22 79.4 0.0 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.17 EFE40498.1 - 3.5e-18 66.0 0.0 8.5e-18 64.7 0.0 1.6 1 1 0 1 1 1 1 CNH domain TPR_1 PF00515.23 EFE40498.1 - 0.083 12.5 0.1 28 4.5 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFE40498.1 - 0.1 12.2 0.1 38 4.0 0.0 3.8 4 0 0 4 4 4 0 TPR repeat 6PF2K PF01591.13 EFE40499.1 - 5.8e-70 234.8 0.3 1.6e-69 233.3 0.2 1.6 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EFE40499.1 - 2.8e-34 118.4 0.0 5e-34 117.6 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EFE40499.1 - 7.3e-07 29.1 0.0 1.9e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain APH PF01636.18 EFE40501.1 - 3.2e-18 66.3 0.0 4.3e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE40501.1 - 4.3e-05 23.1 0.0 6.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.9 EFE40501.1 - 0.0043 16.0 0.0 0.011 14.7 0.0 1.6 2 0 0 2 2 2 1 Fructosamine kinase Pkinase PF00069.20 EFE40501.1 - 0.038 13.1 0.0 0.29 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain RIO1 PF01163.17 EFE40501.1 - 0.13 11.5 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 0 RIO1 family AA_permease PF00324.16 EFE40502.1 - 7.7e-127 423.5 40.8 8.8e-127 423.3 28.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE40502.1 - 3e-35 121.6 43.6 3.4e-35 121.4 30.2 1.0 1 0 0 1 1 1 1 Amino acid permease RdRP PF05183.7 EFE40503.1 - 1.2e-190 635.0 0.1 1.8e-190 634.5 0.1 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_1 PF00076.17 EFE40503.1 - 0.009 15.6 0.0 0.027 14.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2360 PF10152.4 EFE40504.1 - 0.032 14.5 0.3 0.043 14.0 0.2 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Slu7 PF11708.3 EFE40505.1 - 1e-77 261.1 18.3 1e-77 261.1 12.7 2.3 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.1 EFE40505.1 - 0.01 15.5 0.6 0.022 14.4 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.1 EFE40505.1 - 1.7 8.1 5.2 3.5 7.2 3.6 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DNA_pol_B PF00136.16 EFE40506.1 - 1.1e-93 314.5 0.0 1.8e-93 313.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EFE40506.1 - 5e-16 58.4 0.6 4.8e-11 42.1 0.0 2.7 3 0 0 3 3 3 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 EFE40506.1 - 0.00037 20.4 4.2 0.00037 20.4 2.9 2.0 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta Ran-binding PF05508.6 EFE40507.1 - 1.2e-102 342.9 0.0 1.9e-102 342.2 0.0 1.3 1 0 0 1 1 1 1 RanGTP-binding protein CTP_transf_2 PF01467.21 EFE40508.1 - 8.1e-26 90.9 0.0 1.1e-25 90.5 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase GTP_EFTU PF00009.22 EFE40509.1 - 3.6e-42 143.9 0.0 5.1e-42 143.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EFE40509.1 - 4.7e-21 74.8 0.1 9.7e-21 73.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFE40509.1 - 1.1e-08 35.1 0.3 2.4e-08 33.9 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFE40509.1 - 0.0036 17.2 0.0 0.0089 15.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 EFE40509.1 - 0.027 13.1 0.5 0.061 12.0 0.3 1.7 1 1 0 1 1 1 0 G-protein alpha subunit DUF566 PF04484.7 EFE40509.1 - 7.3 6.0 9.2 13 5.1 6.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF566) Aminotran_1_2 PF00155.16 EFE40510.1 - 6.7e-40 137.1 0.0 8.6e-40 136.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFE40510.1 - 0.053 12.2 0.0 1.4 7.5 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EFE40510.1 - 0.077 11.2 0.0 0.11 10.7 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.16 EFE40511.1 - 1.5e-41 142.3 0.0 3.8e-41 141.0 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-III AAA_26 PF13500.1 EFE40511.1 - 9.3e-32 110.2 0.0 1.5e-31 109.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain BATS PF06968.8 EFE40512.1 - 1e-27 95.8 0.0 3.3e-27 94.1 0.0 1.9 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 EFE40512.1 - 4.6e-16 59.4 0.0 8.3e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Oxidored_FMN PF00724.15 EFE40513.1 - 5.9e-64 216.2 0.0 7.6e-64 215.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF2630 PF10944.3 EFE40515.1 - 0.019 15.0 1.1 0.06 13.4 0.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) GST_N_2 PF13409.1 EFE40516.1 - 8e-10 38.5 0.0 1.8e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 EFE40516.1 - 8.9e-10 38.6 0.0 1.5e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFE40516.1 - 3.7e-08 33.4 0.0 6.4e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE40516.1 - 2e-06 27.6 0.1 4.7e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFE40516.1 - 0.00065 19.5 0.2 0.0012 18.7 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE40516.1 - 0.0028 18.0 0.0 0.0048 17.3 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain FAA_hydrolase PF01557.13 EFE40517.1 - 3.7e-48 163.8 0.0 5.4e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.6 EFE40517.1 - 8.7e-25 86.7 0.0 1.6e-24 85.9 0.0 1.5 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal HgmA PF04209.8 EFE40519.1 - 5.3e-182 604.9 0.0 2.7e-181 602.6 0.0 1.8 1 1 0 1 1 1 1 homogentisate 1,2-dioxygenase TPR_17 PF13431.1 EFE40520.1 - 0.014 15.5 0.1 0.19 12.0 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFE40520.1 - 0.063 12.9 0.2 0.63 9.7 0.1 2.2 2 0 0 2 2 2 0 TPR repeat TPR_14 PF13428.1 EFE40520.1 - 0.14 12.8 0.4 0.63 10.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyoxalase PF00903.20 EFE40521.1 - 1.2e-24 86.7 0.9 1.6e-17 63.6 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EFE40521.1 - 2.3e-15 56.5 0.3 7.8e-08 32.2 0.2 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EFE40521.1 - 1.7e-12 47.9 0.0 1.9e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.1 EFE40521.1 - 1.3e-07 31.6 0.1 0.0012 18.7 0.1 2.9 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.1 EFE40521.1 - 0.00024 21.0 0.2 0.0047 16.8 0.2 2.4 1 1 0 1 1 1 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal COX15-CtaA PF02628.10 EFE40522.1 - 2.1e-96 322.3 7.9 2.5e-96 322.1 5.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Prok-RING_2 PF14445.1 EFE40523.1 - 0.08 12.8 5.6 0.15 11.9 3.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 zf-RING_4 PF14570.1 EFE40523.1 - 0.081 12.5 4.2 0.16 11.6 2.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RanBP PF00641.13 EFE40523.1 - 0.67 9.1 10.6 0.016 14.3 2.9 1.7 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others tRNA-synt_2 PF00152.15 EFE40524.1 - 7.6e-91 304.3 0.4 1.1e-90 303.8 0.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFE40524.1 - 3.6e-12 45.9 0.0 9.5e-12 44.6 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EFE40524.1 - 3.7e-06 26.3 0.1 0.0073 15.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Fucose_iso_N2 PF07882.7 EFE40524.1 - 0.076 12.6 0.7 0.2 11.3 0.5 1.7 1 0 0 1 1 1 0 L-fucose isomerase, second N-terminal domain SUKH-3 PF14433.1 EFE40524.1 - 0.078 12.7 0.1 8.8 6.0 0.0 2.5 2 0 0 2 2 2 0 SUKH-3 immunity protein Dynamin_N PF00350.18 EFE40525.1 - 7.6e-24 84.4 0.0 4.1e-23 82.0 0.0 2.1 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFE40525.1 - 1.9e-13 49.8 0.0 2.2e-12 46.3 0.0 2.1 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.18 EFE40525.1 - 0.00056 19.8 0.0 0.016 15.1 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE40525.1 - 0.0016 18.9 0.0 0.005 17.3 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein Ras PF00071.17 EFE40525.1 - 0.13 11.6 0.1 0.26 10.6 0.1 1.5 1 0 0 1 1 1 0 Ras family NTP_transferase PF00483.18 EFE40526.1 - 5.6e-29 101.1 0.0 7.4e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 EFE40526.1 - 2.8e-09 36.0 8.7 1.2e-06 27.7 0.1 3.9 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EFE40526.1 - 5.7e-08 32.9 0.0 8.6e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 EFE40526.1 - 0.0088 15.5 0.0 0.029 13.8 0.0 1.7 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep_2 PF14602.1 EFE40526.1 - 0.098 12.2 3.6 0.25 10.9 0.0 3.0 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Bys1 PF04681.7 EFE40527.1 - 0.0003 20.5 0.1 0.00043 20.0 0.1 1.1 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Pyridox_oxidase PF01243.15 EFE40529.1 - 3e-08 33.5 0.0 0.00097 19.1 0.0 2.9 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.19 EFE40529.1 - 4.1e-07 30.0 0.0 7.9e-05 22.7 0.0 2.7 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EFE40529.1 - 0.1 13.1 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain zf-RING_2 PF13639.1 EFE40530.1 - 6.8e-09 35.4 3.6 1.1e-08 34.8 2.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFE40530.1 - 1.2e-05 25.3 1.1 2.3e-05 24.4 0.7 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EFE40530.1 - 0.0004 20.1 0.4 0.00066 19.4 0.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 EFE40530.1 - 0.011 15.7 2.7 0.018 15.0 1.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_3 PF14369.1 EFE40530.1 - 0.023 14.6 0.1 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 zinc-finger zf-RING_5 PF14634.1 EFE40530.1 - 0.07 12.8 0.3 0.14 11.9 0.2 1.5 1 1 0 1 1 1 0 zinc-RING finger domain WHG PF13305.1 EFE40530.1 - 0.15 12.6 0.0 0.28 11.8 0.0 1.4 1 0 0 1 1 1 0 WHG domain zf-C3HC4_3 PF13920.1 EFE40530.1 - 0.34 10.6 1.8 1.4 8.6 1.2 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Atx10homo_assoc PF09759.4 EFE40531.1 - 2.5e-31 107.4 1.1 8.5e-31 105.7 0.2 2.2 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain DUF3028 PF11229.3 EFE40531.1 - 0.12 10.6 0.0 0.18 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3028) Rap1_C PF11626.3 EFE40532.1 - 5.8e-24 83.7 0.0 6.1e-23 80.5 0.0 2.3 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 EFE40532.1 - 2.1e-08 33.8 0.5 8.7e-08 31.8 0.0 2.3 3 0 0 3 3 3 1 Rap1 Myb domain BRCT PF00533.21 EFE40532.1 - 0.0016 18.5 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Chromo PF00385.19 EFE40533.1 - 7.2e-08 31.9 0.1 1.7e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.14 EFE40533.1 - 7.8e-05 22.4 0.0 0.027 14.3 0.0 2.3 2 0 0 2 2 2 2 Chromo shadow domain PTRF_SDPR PF15237.1 EFE40533.1 - 0.019 14.3 0.6 0.025 13.9 0.4 1.1 1 0 0 1 1 1 0 PTRF/SDPR family DNA_pol_phi PF04931.8 EFE40533.1 - 0.92 7.2 11.8 0.95 7.1 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cpn60_TCP1 PF00118.19 EFE40534.1 - 3.6e-117 391.9 3.2 5.2e-117 391.4 2.2 1.2 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.11 EFE40534.1 - 0.13 12.1 0.9 18 5.2 0.1 2.5 2 0 0 2 2 2 0 Enolase, N-terminal domain RdRP_1 PF00680.15 EFE40535.1 - 0.057 11.6 0.0 0.068 11.4 0.0 1.1 1 0 0 1 1 1 0 RNA dependent RNA polymerase Wbp11 PF09429.5 EFE40537.1 - 1.4e-22 79.4 16.2 1.4e-22 79.4 11.2 2.1 3 0 0 3 3 3 1 WW domain binding protein 11 GHMP_kinases_C PF08544.8 EFE40537.1 - 0.072 13.2 2.2 1.8 8.7 0.0 2.7 2 0 0 2 2 2 0 GHMP kinases C terminal SynMuv_product PF06047.6 EFE40537.1 - 0.51 10.1 4.8 0.21 11.3 0.1 2.5 2 1 0 2 2 2 0 Ras-induced vulval development antagonist Pkinase PF00069.20 EFE40538.1 - 1.1e-58 198.4 0.0 2e-58 197.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40538.1 - 1.2e-36 126.1 0.0 1.2e-35 122.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Reo_sigmaC PF04582.7 EFE40538.1 - 0.084 12.0 0.7 0.13 11.4 0.5 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF607 PF04678.8 EFE40538.1 - 0.93 9.3 4.9 0.73 9.7 2.2 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF607 BTB PF00651.26 EFE40539.1 - 2.6e-14 53.1 1.2 8.9e-14 51.4 0.2 2.2 3 0 0 3 3 3 1 BTB/POZ domain TRP PF06011.7 EFE40540.1 - 2.6e-63 214.1 27.0 5.6e-63 213.0 18.7 1.5 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EFE40540.1 - 3.6e-17 62.7 0.0 6.9e-16 58.5 0.0 2.2 1 1 0 1 1 1 1 ML-like domain PRANC PF09372.5 EFE40541.1 - 0.0052 16.7 0.0 0.0063 16.4 0.0 1.2 1 0 0 1 1 1 1 PRANC domain F-box PF00646.28 EFE40541.1 - 0.0082 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE40541.1 - 0.041 13.6 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 F-box-like RICTOR_V PF14668.1 EFE40541.1 - 0.12 12.3 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 DUF1212 PF06738.7 EFE40544.1 - 4.8e-48 163.1 9.4 5.7e-45 153.1 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 EFE40544.1 - 4.4e-26 91.3 34.9 9.3e-26 90.2 13.3 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF3815) Clathrin_bdg PF15045.1 EFE40545.1 - 0.013 14.9 0.2 0.73 9.3 0.0 2.1 1 1 1 2 2 2 0 Clathrin-binding box of Aftiphilin, vesicle trafficking PS_Dcarbxylase PF02666.10 EFE40546.1 - 2.1e-50 170.8 0.0 3.4e-50 170.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 EFE40546.1 - 3.5e-33 113.3 0.3 6.4e-16 57.9 0.0 2.6 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.1 EFE40546.1 - 0.013 14.8 0.0 0.038 13.3 0.0 1.8 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.27 EFE40546.1 - 0.029 13.6 0.0 0.09 12.1 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 EFE40546.1 - 0.077 13.1 0.2 0.24 11.5 0.2 1.8 1 0 0 1 1 1 0 EF-hand domain pair Presenilin PF01080.12 EFE40548.1 - 4.4 6.0 5.6 5.2 5.7 3.9 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.2 EFE40548.1 - 5.8 4.4 11.3 6.8 4.2 7.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.11 EFE40548.1 - 7.9 6.2 9.9 9.1 6.0 6.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region p450 PF00067.17 EFE40549.1 - 2.8e-26 92.0 0.0 4e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.11 EFE40550.1 - 7.4e-24 84.1 45.2 1.4e-23 83.2 29.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily FPN1 PF06963.7 EFE40550.1 - 2.4 6.4 9.9 0.12 10.7 2.2 2.1 2 1 1 3 3 3 0 Ferroportin1 (FPN1) Fungal_trans PF04082.13 EFE40552.1 - 2.5e-07 29.8 0.1 0.0038 16.1 0.0 2.3 1 1 1 2 2 2 2 Fungal specific transcription factor domain Trp_DMAT PF11991.3 EFE40553.1 - 3.7e-105 352.0 0.0 4.3e-105 351.8 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase AMP-binding PF00501.23 EFE40554.1 - 2e-132 441.5 0.0 3e-66 223.5 0.0 2.6 2 1 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 EFE40554.1 - 1.2e-81 273.8 0.0 1.7e-46 158.4 0.0 2.3 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.20 EFE40554.1 - 1.1e-23 83.2 0.0 9.3e-10 38.6 0.0 3.9 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE40554.1 - 2.4e-14 54.0 0.1 5.4e-06 27.2 0.0 2.8 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain HxxPF_rpt PF13745.1 EFE40554.1 - 4.8e-11 42.8 0.0 2.9e-07 30.7 0.0 2.8 2 0 0 2 2 2 2 HxxPF-repeated domain Transferase PF02458.10 EFE40554.1 - 0.22 9.8 0.0 1 7.7 0.0 1.9 2 0 0 2 2 2 0 Transferase family Methyltransf_2 PF00891.13 EFE40555.1 - 8.2e-32 110.3 0.0 1e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 EFE40555.1 - 0.0034 17.9 0.0 0.0076 16.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40555.1 - 0.13 11.9 0.0 2.7 7.6 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase domain DUF4218 PF13960.1 EFE40555.1 - 0.19 11.2 0.0 0.39 10.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) DIT1_PvcA PF05141.7 EFE40556.1 - 9.3e-86 287.5 0.0 1.4e-85 287.0 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein AMP-binding PF00501.23 EFE40556.1 - 1.1e-25 89.9 0.0 1.7e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Transferase PF02458.10 EFE40556.1 - 1.6e-13 49.9 0.0 1e-05 24.2 0.0 2.7 2 1 0 2 2 2 2 Transferase family PP-binding PF00550.20 EFE40556.1 - 9.2e-09 35.4 0.0 2.1e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Proho_convert PF12177.3 EFE40556.1 - 0.08 12.5 0.3 0.22 11.1 0.2 1.7 1 0 0 1 1 1 0 Prohormone convertase enzyme MFS_1 PF07690.11 EFE40557.1 - 1.4e-16 60.2 58.0 1.3e-11 43.8 25.2 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1 PF07690.11 EFE40558.1 - 5.4e-15 54.9 68.9 2.8e-09 36.1 16.3 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.8 EFE40558.1 - 1.1e-05 23.8 25.4 1.6e-05 23.3 17.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) WSC PF01822.14 EFE40559.1 - 8.3e-43 144.2 43.2 8.2e-19 67.3 7.4 3.4 3 0 0 3 3 3 3 WSC domain Glyoxal_oxid_N PF07250.6 EFE40559.1 - 8.7e-28 97.0 0.0 9.9e-27 93.5 0.0 2.5 2 1 1 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 EFE40559.1 - 1.2e-20 73.4 0.0 2.3e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_2 PF07646.10 EFE40559.1 - 0.027 14.2 0.0 0.37 10.6 0.0 3.1 2 0 0 2 2 2 0 Kelch motif E1-E2_ATPase PF00122.15 EFE40560.1 - 5.5e-61 205.5 6.8 8.9e-61 204.8 4.7 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 EFE40560.1 - 4.8e-12 45.1 1.1 2e-11 43.2 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.21 EFE40560.1 - 3e-10 40.8 0.0 1.3e-09 38.8 0.0 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFE40560.1 - 4.2e-07 30.3 0.0 1.2e-06 28.8 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE40560.1 - 0.0026 17.6 0.0 0.0052 16.7 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Curto_V3 PF07436.6 EFE40560.1 - 0.24 11.5 0.8 2.4 8.3 0.0 2.7 2 0 0 2 2 2 0 Curtovirus V3 protein RRM_1 PF00076.17 EFE40561.1 - 1.5e-07 30.9 0.0 2.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE40561.1 - 4.4e-07 29.6 0.1 1.1e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40561.1 - 7.8e-06 25.7 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) LNS2 PF08235.8 EFE40562.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) DSPc PF00782.15 EFE40563.1 - 8.3e-20 70.7 0.0 1.3e-15 57.1 0.0 2.1 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFE40563.1 - 0.0013 18.0 1.7 0.0022 17.3 0.1 2.1 1 1 1 2 2 2 1 Protein-tyrosine phosphatase Citrate_synt PF00285.16 EFE40564.1 - 1.8e-94 316.3 0.0 2.7e-83 279.6 0.0 2.2 1 1 1 2 2 2 2 Citrate synthase Cnd2 PF05786.9 EFE40567.1 - 0.31 9.4 2.3 0.33 9.4 1.6 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 Mito_carr PF00153.22 EFE40568.1 - 6.2e-26 89.9 8.3 1.2e-11 44.1 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Peptidase_M16 PF00675.15 EFE40569.1 - 2.6e-18 66.2 0.0 4.7e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EFE40569.1 - 1.1e-14 54.5 0.0 1.8e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain RNA_pol_Rpc82 PF05645.8 EFE40570.1 - 3.6e-39 134.8 4.9 1.9e-35 122.6 0.0 3.1 2 2 1 3 3 3 3 RNA polymerase III subunit RPC82 HTH_9 PF08221.6 EFE40570.1 - 2.8e-16 59.1 2.8 2e-09 37.1 0.1 3.8 4 0 0 4 4 4 3 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.12 EFE40570.1 - 6.7e-08 31.9 0.1 9.4e-07 28.2 0.1 2.6 2 1 1 3 3 3 1 TFIIE alpha subunit TrmB PF01978.14 EFE40570.1 - 0.046 13.4 0.1 1.9 8.2 0.0 3.2 4 0 0 4 4 4 0 Sugar-specific transcriptional regulator TrmB CENP-B_dimeris PF09026.5 EFE40570.1 - 0.15 12.2 9.5 0.12 12.6 0.3 3.8 4 0 0 4 4 4 0 Centromere protein B dimerisation domain Sec8_exocyst PF04048.9 EFE40571.1 - 1.3e-42 144.7 0.7 1.3e-42 144.7 0.5 2.3 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain DUF2450 PF10475.4 EFE40571.1 - 1.2e-08 34.2 0.4 2.3e-08 33.3 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Sec5 PF15469.1 EFE40571.1 - 0.029 14.0 0.1 0.073 12.7 0.1 1.7 1 0 0 1 1 1 0 Exocyst complex component Sec5 COG2 PF06148.6 EFE40571.1 - 1.1 9.1 6.0 0.19 11.5 0.4 2.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Fungal_trans_2 PF11951.3 EFE40573.1 - 1.2e-05 24.1 3.3 2.3e-05 23.1 2.3 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Tannase PF07519.6 EFE40574.1 - 2.7e-100 336.3 0.1 3.6e-100 335.9 0.1 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.16 EFE40574.1 - 3.7e-06 26.3 0.0 0.041 13.1 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFE40574.1 - 0.0015 18.4 0.0 0.003 17.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE40574.1 - 0.032 13.9 0.1 1.8 8.3 0.1 2.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Aldo_ket_red PF00248.16 EFE40575.1 - 1.4e-30 106.0 0.0 3.1e-30 104.9 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family Init_tRNA_PT PF04179.7 EFE40576.1 - 2.6e-80 270.5 0.0 3.1e-80 270.2 0.0 1.0 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase Init_tRNA_PT PF04179.7 EFE40577.1 - 4.2e-44 151.1 0.0 4.7e-44 150.9 0.0 1.0 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase HAD_2 PF13419.1 EFE40579.1 - 4.5e-15 56.3 0.0 5.6e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE40579.1 - 3.4e-07 29.8 0.0 6e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.13 EFE40579.1 - 1.6e-06 27.8 0.0 7.2e-05 22.4 0.0 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.21 EFE40579.1 - 0.0025 18.2 0.0 0.063 13.6 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HipA_N PF07805.7 EFE40579.1 - 0.11 12.7 0.1 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 HipA-like N-terminal domain Ank PF00023.25 EFE40579.1 - 0.16 11.8 0.0 0.39 10.6 0.0 1.7 2 0 0 2 2 2 0 Ankyrin repeat Glycos_transf_3 PF00591.16 EFE40580.1 - 2.5e-56 190.9 0.0 1.4e-53 181.8 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 EFE40580.1 - 1.9e-05 24.1 0.3 5.7e-05 22.6 0.2 1.8 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain fn3 PF00041.16 EFE40581.1 - 2.4e-12 46.7 5.0 5.3e-07 29.6 0.0 4.3 4 1 0 4 4 4 2 Fibronectin type III domain Lipase_GDSL_2 PF13472.1 EFE40581.1 - 2.8e-08 34.0 0.2 8.6e-08 32.5 0.1 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFE40581.1 - 0.00071 19.4 0.0 0.0029 17.4 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Fe_hyd_lg_C PF02906.9 EFE40583.1 - 1e-60 205.4 0.0 1.7e-60 204.7 0.0 1.4 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain DUF2263 PF10021.4 EFE40584.1 - 4.8e-29 101.2 0.0 2.4e-28 98.9 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2263) Fapy_DNA_glyco PF01149.19 EFE40585.1 - 4e-25 88.4 0.0 6.6e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.9 EFE40585.1 - 6.5e-09 35.4 0.0 1e-07 31.5 0.0 2.3 1 1 1 2 2 2 1 Formamidopyrimidine-DNA glycosylase H2TH domain Mitofilin PF09731.4 EFE40585.1 - 0.035 12.7 8.0 0.05 12.2 5.6 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein XRCC4 PF06632.7 EFE40585.1 - 9 5.0 10.0 12 4.6 6.9 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 NARP1 PF12569.3 EFE40586.1 - 1.6e-209 697.0 3.0 1.6e-209 697.0 2.1 1.7 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_14 PF13428.1 EFE40586.1 - 3.2e-23 80.0 11.5 0.00088 19.7 1.3 9.7 9 1 1 10 10 9 4 Tetratricopeptide repeat TPR_2 PF07719.12 EFE40586.1 - 1.5e-18 65.1 29.2 7.5e-05 22.3 0.4 9.9 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_19 PF14559.1 EFE40586.1 - 2.6e-17 62.8 24.6 4.3e-05 23.7 0.0 6.8 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 EFE40586.1 - 1.1e-15 57.0 29.7 4.4e-05 23.0 2.1 7.3 7 2 1 8 8 7 5 TPR repeat TPR_16 PF13432.1 EFE40586.1 - 1.7e-14 54.0 17.8 0.00092 19.8 0.6 7.6 7 1 2 9 9 8 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFE40586.1 - 1.3e-10 40.4 29.8 1.1e-05 24.8 0.4 8.4 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_9 PF13371.1 EFE40586.1 - 4.5e-10 39.2 13.8 0.011 15.5 0.8 6.4 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFE40586.1 - 1.9e-09 36.6 11.0 0.0013 18.3 0.1 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 EFE40586.1 - 6.8e-08 32.1 16.5 0.041 14.0 0.0 7.3 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFE40586.1 - 2.2e-07 30.7 24.3 0.00096 19.0 0.2 7.6 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_15 PF13429.1 EFE40586.1 - 2.9e-05 23.2 11.8 0.029 13.4 0.3 3.7 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE40586.1 - 3.4e-05 23.3 13.3 0.44 10.4 0.3 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE40586.1 - 4.6e-05 23.4 11.6 0.48 10.6 1.1 5.4 4 2 2 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.12 EFE40586.1 - 8.5e-05 22.8 1.7 0.00089 19.5 0.1 2.9 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_6 PF13174.1 EFE40586.1 - 0.00022 21.4 18.5 0.077 13.4 0.1 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_3 PF07720.7 EFE40586.1 - 0.00069 19.3 5.9 0.012 15.3 0.1 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_21 PF09976.4 EFE40586.1 - 0.014 15.3 0.0 0.014 15.3 0.0 3.7 5 0 0 5 5 2 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFE40586.1 - 0.27 11.7 11.9 3.3 8.4 1.4 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EFE40586.1 - 1 9.3 8.9 34 4.4 0.2 5.0 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.1 EFE40586.1 - 1.1 9.2 17.0 16 5.6 1.4 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat Tim54 PF11711.3 EFE40587.1 - 8.2e-126 419.6 0.0 1e-125 419.3 0.0 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Pkinase PF00069.20 EFE40588.1 - 1.1e-53 182.0 0.1 1.6e-37 129.0 0.2 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40588.1 - 3.1e-24 85.4 0.3 7.5e-19 67.8 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFE40588.1 - 0.0001 21.4 0.0 0.0002 20.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFE40588.1 - 0.0015 17.6 0.0 0.0033 16.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE40588.1 - 0.0057 16.4 4.0 0.017 14.8 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_C PF00433.19 EFE40588.1 - 0.013 15.9 0.0 0.037 14.5 0.0 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain Seadorna_VP7 PF07387.6 EFE40588.1 - 0.039 12.7 0.0 0.065 12.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PepX_N PF09168.5 EFE40588.1 - 0.051 13.8 0.6 0.11 12.6 0.4 1.5 1 0 0 1 1 1 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal Pox_ser-thr_kin PF05445.6 EFE40588.1 - 0.067 11.9 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3441 PF11923.3 EFE40588.1 - 0.15 11.6 0.2 0.3 10.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3441) SpoIIIAH PF12685.2 EFE40588.1 - 0.2 11.1 1.2 0.34 10.3 0.8 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein RIO1 PF01163.17 EFE40588.1 - 0.24 10.7 2.5 0.35 10.1 0.0 2.1 2 0 0 2 2 2 0 RIO1 family zf-met PF12874.2 EFE40589.1 - 2.1e-05 24.5 0.6 3.8e-05 23.7 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.6 EFE40589.1 - 0.046 12.9 0.9 0.095 11.9 0.6 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Methyltransf_11 PF08241.7 EFE40590.1 - 2.8e-11 43.7 0.0 5.7e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE40590.1 - 3.4e-08 34.0 0.0 9.4e-08 32.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40590.1 - 1.3e-07 31.9 0.0 2.6e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40590.1 - 1.6e-07 31.2 0.0 2.5e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE40590.1 - 0.002 17.7 0.0 0.0032 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE40590.1 - 0.019 15.2 0.0 0.058 13.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 EFE40590.1 - 0.07 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.13 EFE40591.1 - 5e-08 32.4 0.0 5.5e-08 32.3 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase MFS_1 PF07690.11 EFE40592.1 - 6.9e-41 140.1 35.6 7.5e-41 140.0 21.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40592.1 - 4.1e-11 42.1 9.5 4.1e-11 42.1 6.6 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_2 PF13347.1 EFE40592.1 - 4.5e-06 25.3 15.0 0.0014 17.0 0.3 3.0 2 1 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.2 EFE40592.1 - 0.043 13.5 6.7 0.089 12.5 0.4 3.6 4 0 0 4 4 4 0 MFS_1 like family CAP_GLY PF01302.20 EFE40593.1 - 9.6e-19 66.8 0.0 1.6e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.2 EFE40593.1 - 1.1e-11 44.0 13.9 0.00012 21.6 0.6 4.8 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE40593.1 - 0.00012 21.7 13.2 0.0041 16.8 0.7 3.9 4 1 1 5 5 5 2 Leucine rich repeat LRR_6 PF13516.1 EFE40593.1 - 0.00037 20.2 4.3 13 6.2 0.0 5.4 6 0 0 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.28 EFE40593.1 - 0.0013 18.4 12.5 0.86 9.8 0.0 6.5 4 2 1 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 EFE40593.1 - 0.021 14.9 2.0 75 4.2 0.0 5.7 6 0 0 6 6 6 0 Leucine rich repeat LRR_9 PF14580.1 EFE40593.1 - 0.27 10.7 3.4 3.3 7.2 0.1 3.1 2 1 1 3 3 3 0 Leucine-rich repeat zf-U1 PF06220.7 EFE40594.1 - 4.9e-08 32.3 0.5 9.2e-08 31.5 0.4 1.5 1 0 0 1 1 1 1 U1 zinc finger ABC_tran_2 PF12848.2 EFE40594.1 - 0.11 12.2 8.9 0.15 11.9 0.1 2.7 2 1 0 2 2 2 0 ABC transporter 2-Hacid_dh_C PF02826.14 EFE40596.1 - 3.3e-54 182.7 0.0 6.3e-54 181.8 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 EFE40596.1 - 0.016 15.0 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase CwfJ_C_1 PF04677.10 EFE40597.1 - 1.7e-29 101.9 0.0 3.1e-29 101.1 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 EFE40597.1 - 7.9e-25 87.2 0.0 3.7e-24 85.0 0.0 2.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 FumaraseC_C PF10415.4 EFE40597.1 - 0.082 12.9 0.2 12 6.0 0.0 2.8 2 0 0 2 2 2 0 Fumarase C C-terminus ATP_bind_1 PF03029.12 EFE40598.1 - 6.1e-75 251.8 0.0 8e-75 251.4 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 EFE40598.1 - 0.00018 21.0 0.0 0.0055 16.1 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 EFE40598.1 - 0.00026 21.1 0.0 0.0008 19.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EFE40598.1 - 0.00043 20.2 0.0 0.0014 18.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ArgK PF03308.11 EFE40598.1 - 0.00043 19.1 0.0 0.055 12.2 0.0 2.3 2 0 0 2 2 2 1 ArgK protein SRP54 PF00448.17 EFE40598.1 - 0.00077 18.9 0.0 0.02 14.3 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_10 PF12846.2 EFE40598.1 - 0.0013 18.2 0.6 0.0024 17.3 0.4 1.8 1 1 0 1 1 1 1 AAA-like domain Miro PF08477.8 EFE40598.1 - 0.0029 18.0 0.0 2.6 8.5 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein CbiA PF01656.18 EFE40598.1 - 0.0035 16.7 0.0 0.01 15.2 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.7 EFE40598.1 - 0.0042 16.7 0.0 0.0092 15.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain MobB PF03205.9 EFE40598.1 - 0.0045 16.6 0.0 0.009 15.7 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B PRK PF00485.13 EFE40598.1 - 0.005 16.4 0.0 0.018 14.6 0.0 1.8 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family FeoB_N PF02421.13 EFE40598.1 - 0.005 16.1 0.0 0.09 12.0 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_33 PF13671.1 EFE40598.1 - 0.0068 16.2 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.14 EFE40598.1 - 0.01 15.3 0.0 0.96 8.8 0.0 2.5 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.16 EFE40598.1 - 0.018 14.2 0.0 2.2 7.4 0.0 2.9 3 0 0 3 3 3 0 ADP-ribosylation factor family AAA_30 PF13604.1 EFE40598.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EFE40598.1 - 0.026 14.8 0.0 1 9.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EFE40598.1 - 0.027 13.3 0.0 0.049 12.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.1 EFE40598.1 - 0.03 14.3 0.0 0.17 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.4 EFE40598.1 - 0.11 11.9 0.1 0.77 9.2 0.0 2.4 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 EFE40598.1 - 0.13 13.1 0.0 0.13 13.1 0.0 2.3 2 1 0 2 2 1 0 AAA domain AAA_18 PF13238.1 EFE40598.1 - 0.21 11.9 2.4 2.6 8.3 0.0 3.3 3 1 0 3 3 3 0 AAA domain G-alpha PF00503.15 EFE40598.1 - 0.98 8.0 5.7 3 6.4 0.0 3.0 3 0 0 3 3 3 0 G-protein alpha subunit GST_N_3 PF13417.1 EFE40599.1 - 2.3e-23 82.2 0.0 5.6e-23 80.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE40599.1 - 3.6e-14 52.5 0.0 9.4e-14 51.1 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE40599.1 - 1.3e-05 24.9 0.2 3.1e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFE40599.1 - 0.00022 21.3 0.1 0.00056 20.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.19 EFE40599.1 - 0.029 14.3 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin SUZ PF12752.2 EFE40600.1 - 0.00046 20.6 5.2 0.0039 17.6 1.8 4.1 2 2 1 3 3 3 2 SUZ domain SUZ-C PF12901.2 EFE40600.1 - 0.023 14.3 2.9 0.023 14.3 2.0 2.3 2 0 0 2 2 2 0 SUZ-C motif Serglycin PF04360.7 EFE40601.1 - 0.83 9.3 3.1 3 7.5 2.2 1.9 1 1 0 1 1 1 0 Serglycin F-box-like PF12937.2 EFE40602.1 - 3.3e-05 23.5 0.2 9.6e-05 22.0 0.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 EFE40602.1 - 8.7e-05 22.0 13.5 0.16 11.5 0.1 5.3 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EFE40602.1 - 0.00086 19.0 7.1 27 5.3 0.0 6.2 5 0 0 5 5 5 0 Leucine Rich Repeat Ycf1 PF05758.7 EFE40602.1 - 0.0049 14.6 0.2 0.42 8.2 0.1 2.1 2 0 0 2 2 2 2 Ycf1 IncA PF04156.9 EFE40602.1 - 0.041 13.4 0.0 0.041 13.4 0.0 2.6 3 1 0 3 3 3 0 IncA protein LRR_7 PF13504.1 EFE40602.1 - 0.19 12.0 9.4 81 4.1 0.1 6.4 7 0 0 7 7 6 0 Leucine rich repeat LRR_6 PF13516.1 EFE40602.1 - 0.34 11.1 12.5 12 6.3 0.1 5.8 7 0 0 7 7 6 0 Leucine Rich repeat Peptidase_S49_N PF08496.5 EFE40602.1 - 0.64 9.7 3.0 3.5 7.4 0.0 3.0 3 0 0 3 3 3 0 Peptidase family S49 N-terminal LRR_8 PF13855.1 EFE40602.1 - 0.75 9.5 15.2 0.32 10.7 0.8 4.6 4 1 0 4 4 4 0 Leucine rich repeat F-box PF00646.28 EFE40602.1 - 1.3 8.7 8.8 0.3 10.7 0.6 3.1 2 1 0 2 2 2 0 F-box domain Pex24p PF06398.6 EFE40602.1 - 1.4 7.6 10.3 0.34 9.6 0.2 2.9 2 1 0 3 3 3 0 Integral peroxisomal membrane peroxin DUF4131 PF13567.1 EFE40602.1 - 6.9 6.0 10.6 5.9 6.2 3.7 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) CDC45 PF02724.9 EFE40602.1 - 8.7 4.2 11.7 0.27 9.2 2.8 2.0 2 0 0 2 2 2 0 CDC45-like protein AA_permease_2 PF13520.1 EFE40605.1 - 2.8e-43 148.0 40.5 3.4e-43 147.7 28.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE40605.1 - 7.8e-19 67.3 38.6 1e-18 66.9 26.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF962 PF06127.6 EFE40605.1 - 0.025 14.4 5.1 0.99 9.3 0.1 3.6 2 2 0 2 2 2 0 Protein of unknown function (DUF962) p450 PF00067.17 EFE40606.1 - 2.6e-49 168.0 0.0 1.8e-48 165.2 0.0 2.2 1 1 0 1 1 1 1 Cytochrome P450 APH PF01636.18 EFE40607.1 - 3.8e-15 56.2 0.0 5.1e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE40607.1 - 4e-09 36.3 0.0 1.6e-08 34.4 0.0 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase BSD PF03909.12 EFE40608.1 - 1.6e-23 82.1 4.1 1.7e-13 50.0 0.6 2.8 2 0 0 2 2 2 2 BSD domain TFIIH_BTF_p62_N PF08567.6 EFE40608.1 - 2.4e-19 68.7 0.1 6.3e-19 67.4 0.1 1.8 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain TetR PF13972.1 EFE40608.1 - 0.018 14.4 0.1 0.11 11.9 0.0 2.2 2 0 0 2 2 2 0 Bacterial transcriptional repressor ING PF12998.2 EFE40610.1 - 1.4e-07 31.7 0.0 2.8e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 EFE40610.1 - 3.9e-07 29.6 0.9 6.8e-07 28.8 0.6 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 EFE40610.1 - 0.11 12.6 0.3 0.23 11.6 0.2 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain SIT PF15330.1 EFE40610.1 - 1.5 9.0 4.3 7.2 6.8 0.7 2.8 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Transket_pyr PF02779.19 EFE40611.1 - 2.3e-66 222.6 0.0 3.9e-66 221.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 EFE40611.1 - 5.6e-55 186.1 0.0 7.8e-55 185.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DUF2247 PF10004.4 EFE40611.1 - 0.02 14.5 0.1 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) DUF1162 PF06650.7 EFE40612.1 - 3.9e-85 285.4 0.0 3.7e-83 278.9 0.0 3.5 3 1 1 4 4 4 1 Protein of unknown function (DUF1162) Chorein_N PF12624.2 EFE40612.1 - 4.6e-35 119.6 0.0 1.4e-34 118.1 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter ATG_C PF09333.6 EFE40612.1 - 0.0053 16.8 0.0 0.066 13.3 0.0 2.7 2 0 0 2 2 2 1 ATG C terminal domain DUF3429 PF11911.3 EFE40613.1 - 1.1e-40 138.9 11.6 1.6e-40 138.3 8.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) FGGY_C PF02782.11 EFE40614.1 - 8.2e-66 221.3 0.5 2e-65 220.1 0.2 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFE40614.1 - 4.7e-64 216.0 0.0 6.5e-64 215.5 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.15 EFE40614.1 - 0.076 12.2 0.5 0.4 9.9 0.0 2.0 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Peptidase_M41 PF01434.13 EFE40615.1 - 2.1e-62 210.3 0.1 3.8e-62 209.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 EFE40615.1 - 2.2e-42 144.3 0.0 4.7e-42 143.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE40615.1 - 3.2e-06 27.9 0.1 1.3e-05 26.0 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 EFE40615.1 - 5.8e-06 26.4 1.3 2.4e-05 24.4 0.0 2.5 3 1 0 3 3 2 1 AAA ATPase domain AAA_5 PF07728.9 EFE40615.1 - 1.6e-05 24.6 0.0 4.6e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EFE40615.1 - 4.1e-05 22.4 0.0 8.2e-05 21.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_22 PF13401.1 EFE40615.1 - 4.7e-05 23.5 0.2 0.004 17.2 0.1 2.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFE40615.1 - 0.00067 18.7 0.0 0.0015 17.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 EFE40615.1 - 0.00088 18.7 1.4 0.06 12.7 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.9 EFE40615.1 - 0.0011 18.8 0.0 0.004 17.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 EFE40615.1 - 0.0014 18.0 0.0 0.0028 17.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 EFE40615.1 - 0.0024 17.7 0.0 0.0069 16.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE40615.1 - 0.0024 17.5 0.3 0.0073 16.0 0.2 1.8 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 EFE40615.1 - 0.0058 15.7 0.5 0.017 14.2 0.2 1.9 1 1 1 2 2 2 1 Zeta toxin AAA_14 PF13173.1 EFE40615.1 - 0.0062 16.4 0.0 0.025 14.4 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.1 EFE40615.1 - 0.01 15.8 0.3 0.03 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFE40615.1 - 0.014 15.6 0.0 0.047 13.9 0.0 2.0 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.16 EFE40615.1 - 0.016 14.3 0.3 0.032 13.4 0.2 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 EFE40615.1 - 0.018 13.9 0.0 0.035 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.7 EFE40615.1 - 0.018 14.6 0.3 1.3 8.6 0.1 2.4 2 0 0 2 2 2 0 NACHT domain KaiC PF06745.8 EFE40615.1 - 0.03 13.4 0.1 1.2 8.2 0.0 2.6 3 0 0 3 3 3 0 KaiC NTP_transferase PF00483.18 EFE40617.1 - 1.7e-30 106.1 0.0 3.2e-30 105.2 0.0 1.4 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.19 EFE40617.1 - 1.7e-17 62.0 17.8 4e-10 38.7 1.2 4.0 1 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFE40617.1 - 5.7e-07 28.9 1.3 5.7e-07 28.9 0.9 3.1 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.2 EFE40617.1 - 2e-05 24.7 0.0 3.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain adh_short PF00106.20 EFE40618.1 - 9.4e-05 22.3 0.0 0.06 13.2 0.1 3.2 2 1 0 2 2 2 2 short chain dehydrogenase Ctr PF04145.10 EFE40619.1 - 0.081 12.9 0.0 0.095 12.7 0.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Suc_Fer-like PF06999.7 EFE40621.1 - 1.1e-32 113.9 0.0 4.8e-32 111.8 0.0 1.9 1 1 0 1 1 1 1 Sucrase/ferredoxin-like Opiods_neuropep PF01160.13 EFE40621.1 - 1.2 9.0 3.3 0.59 9.9 0.6 1.7 2 0 0 2 2 2 0 Vertebrate endogenous opioids neuropeptide DUF4129 PF13559.1 EFE40622.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) GCFC PF07842.7 EFE40623.1 - 1.4e-85 286.9 10.2 2.3e-85 286.3 7.0 1.3 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.18 EFE40623.1 - 8.9e-16 57.4 0.4 1.7e-15 56.5 0.3 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 EFE40623.1 - 1.9e-07 30.8 0.1 7.8e-07 28.8 0.1 2.1 1 0 0 1 1 1 1 DExH-box splicing factor binding site DUF4455 PF14643.1 EFE40623.1 - 0.0014 17.3 1.3 0.0024 16.5 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) ATP-synt_E PF05680.7 EFE40623.1 - 0.051 13.5 1.5 0.25 11.3 1.1 2.2 1 0 0 1 1 1 0 ATP synthase E chain FHIPEP PF00771.15 EFE40623.1 - 0.29 9.4 1.1 0.42 8.8 0.8 1.1 1 0 0 1 1 1 0 FHIPEP family Sod_Fe_N PF00081.17 EFE40624.1 - 5.9e-30 103.3 0.9 9.3e-30 102.7 0.6 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.13 EFE40624.1 - 9.6e-22 76.8 1.8 8.2e-14 51.3 0.0 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Spc7 PF08317.6 EFE40625.1 - 0.3 9.7 14.2 0.094 11.3 8.0 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein APG6 PF04111.7 EFE40625.1 - 0.71 8.8 15.8 1.2 8.1 10.9 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Microtub_assoc PF07989.6 EFE40625.1 - 1.1 9.0 14.8 0.4 10.5 2.0 2.5 1 1 1 2 2 2 0 Microtubule associated IncA PF04156.9 EFE40625.1 - 8.4 5.9 17.7 16 4.9 12.3 1.5 1 0 0 1 1 1 0 IncA protein Ribosomal_60s PF00428.14 EFE40627.1 - 0.022 15.1 29.6 0.19 12.1 6.8 4.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein Sigma70_ner PF04546.8 EFE40627.1 - 2.5 7.6 14.8 0.67 9.5 3.4 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region Nucleoplasmin PF03066.10 EFE40627.1 - 7.4 6.0 15.8 0.46 9.9 7.3 1.7 2 0 0 2 2 2 0 Nucleoplasmin Zip PF02535.17 EFE40628.1 - 1.5 7.7 4.3 3 6.7 3.0 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter PH_10 PF15411.1 EFE40630.1 - 6.3e-32 110.1 0.1 1.1e-31 109.3 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.19 EFE40630.1 - 6.7e-08 32.0 0.0 1.6e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 PB1 domain CDC24 PF06395.6 EFE40631.1 - 4.3e-31 106.8 0.0 2e-30 104.6 0.0 2.0 2 0 0 2 2 2 1 CDC24 Calponin RhoGEF PF00621.15 EFE40631.1 - 4.2e-30 104.9 0.6 8.8e-30 103.9 0.4 1.5 1 0 0 1 1 1 1 RhoGEF domain DUF4119 PF13494.1 EFE40631.1 - 0.078 12.9 0.3 1.1 9.2 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF4119) WD40 PF00400.27 EFE40632.1 - 4e-39 131.1 13.2 4.2e-07 29.5 0.0 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.2 EFE40632.1 - 6.3e-12 45.0 0.2 1.2e-11 44.0 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE40632.1 - 1.5e-07 30.8 0.1 3.8e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain BBS2_Mid PF14783.1 EFE40632.1 - 0.001 18.7 0.0 2.3 8.0 0.0 3.7 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 EFE40632.1 - 0.057 11.5 0.1 2.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Uds1 PF15456.1 EFE40634.1 - 1.1e-40 138.4 3.2 1.1e-40 138.4 2.2 6.6 6 2 1 7 7 7 2 Up-regulated During Septation TMF_DNA_bd PF12329.3 EFE40634.1 - 0.00015 21.5 10.1 0.00015 21.5 7.0 9.3 9 2 2 11 11 11 3 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.1 EFE40634.1 - 0.082 11.3 46.6 0.056 11.8 11.5 3.9 2 1 1 3 3 3 0 AAA domain TPR_MLP1_2 PF07926.7 EFE40634.1 - 0.14 11.9 0.0 0.14 11.9 0.0 7.4 3 3 2 6 6 6 0 TPR/MLP1/MLP2-like protein DivIC PF04977.10 EFE40634.1 - 0.26 10.7 0.1 0.26 10.7 0.0 8.5 7 2 3 10 10 10 0 Septum formation initiator ApoO PF09769.4 EFE40634.1 - 0.36 10.5 11.7 0.6 9.7 1.4 3.8 3 1 1 4 4 4 0 Apolipoprotein O LINES_N PF14694.1 EFE40634.1 - 0.75 9.0 8.2 0.04 13.1 0.6 2.3 1 1 1 2 2 2 0 Lines N-terminus MFS_1 PF07690.11 EFE40635.1 - 1.8e-19 69.7 31.3 3e-19 68.9 21.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UCR_hinge PF02320.11 EFE40636.1 - 2.4e-21 75.4 5.3 2.4e-21 75.4 3.7 1.9 1 1 1 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein Sigma70_ner PF04546.8 EFE40636.1 - 0.0018 17.8 5.3 0.002 17.7 3.6 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region DUF4363 PF14276.1 EFE40636.1 - 0.012 15.3 0.2 0.015 14.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Daxx PF03344.10 EFE40636.1 - 0.017 13.6 11.7 0.018 13.5 8.1 1.1 1 0 0 1 1 1 0 Daxx Family HSP90 PF00183.13 EFE40636.1 - 0.037 12.4 5.8 0.042 12.2 4.0 1.0 1 0 0 1 1 1 0 Hsp90 protein DUF3530 PF12048.3 EFE40636.1 - 0.087 11.7 2.4 0.1 11.5 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Pox_RNA_Pol_19 PF05320.7 EFE40636.1 - 1.5 8.5 7.3 2 8.1 5.0 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Nop14 PF04147.7 EFE40636.1 - 1.6 6.5 9.7 1.7 6.4 6.7 1.1 1 0 0 1 1 1 0 Nop14-like family VID27 PF08553.5 EFE40636.1 - 1.9 6.6 5.7 2.1 6.4 3.9 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein WWbp PF10349.4 EFE40637.1 - 2.2e-19 70.4 0.5 4.7e-19 69.3 0.3 1.5 1 0 0 1 1 1 1 WW-domain ligand protein Vps36_ESCRT-II PF11605.3 EFE40637.1 - 0.00011 21.9 0.0 0.048 13.4 0.0 2.3 1 1 1 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 DUF3439 PF11921.3 EFE40637.1 - 0.017 14.9 5.2 0.021 14.5 2.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) GRAM PF02893.15 EFE40637.1 - 0.021 14.3 0.0 0.047 13.1 0.0 1.5 1 1 0 1 1 1 0 GRAM domain DUF1929 PF09118.6 EFE40637.1 - 0.078 13.0 0.4 0.37 10.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1929) Mucin PF01456.12 EFE40637.1 - 0.85 9.3 12.8 1.4 8.7 8.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.7 EFE40637.1 - 1.1 6.9 3.6 1.4 6.6 2.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.6 EFE40637.1 - 3.8 5.3 10.6 5.4 4.8 7.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Plasmodium_Vir PF05795.6 EFE40638.1 - 0.26 10.4 6.2 0.39 9.8 4.3 1.5 1 1 0 1 1 1 0 Plasmodium vivax Vir protein MIP-T3 PF10243.4 EFE40638.1 - 1.2 7.5 49.3 1.6 7.1 34.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Acyltransferase PF01553.16 EFE40640.1 - 1.3e-10 40.8 0.0 0.00012 21.4 0.0 2.4 2 0 0 2 2 2 2 Acyltransferase Prenyltransf PF01255.14 EFE40641.1 - 8.6e-81 270.3 0.0 1.5e-80 269.5 0.0 1.4 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Zip PF02535.17 EFE40641.1 - 0.42 9.5 11.2 0.73 8.7 7.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.11 EFE40641.1 - 0.52 10.1 4.6 1 9.1 3.2 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.2 EFE40641.1 - 1.5 6.4 7.7 2.1 5.9 5.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.4 EFE40641.1 - 2.5 6.2 9.0 4.5 5.4 6.2 1.4 1 0 0 1 1 1 0 Transmembrane protein Saccharop_dh PF03435.13 EFE40643.1 - 2.6e-87 293.3 0.0 8.5e-87 291.6 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase UPF0231 PF06062.6 EFE40644.1 - 0.19 11.6 3.3 0.21 11.4 2.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) BLVR PF06375.6 EFE40646.1 - 0.14 11.9 6.1 0.18 11.6 4.2 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) RF-1 PF00472.15 EFE40646.1 - 0.16 11.8 4.3 0.2 11.4 3.0 1.3 1 0 0 1 1 1 0 RF-1 domain G10 PF01125.12 EFE40646.1 - 0.29 10.7 2.8 0.36 10.3 2.0 1.2 1 0 0 1 1 1 0 G10 protein Clathrin_lg_ch PF01086.12 EFE40646.1 - 0.37 10.6 10.4 0.43 10.4 7.2 1.0 1 0 0 1 1 1 0 Clathrin light chain RR_TM4-6 PF06459.7 EFE40646.1 - 0.47 10.2 6.9 0.52 10.1 4.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PTN_MK_N PF05196.8 EFE40646.1 - 2.8 7.9 6.6 11 6.0 0.1 2.2 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, N-terminal domain DUF4602 PF15375.1 EFE40646.1 - 3.2 7.8 15.4 4.6 7.3 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4602) PBP_sp32 PF07222.7 EFE40646.1 - 4.6 6.3 7.2 4.9 6.2 5.0 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Ribosomal_60s PF00428.14 EFE40647.1 - 0.00016 22.0 4.9 0.00018 21.8 3.4 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Myc_N PF01056.13 EFE40647.1 - 0.07 12.2 2.9 0.069 12.3 2.0 1.1 1 0 0 1 1 1 0 Myc amino-terminal region eIF3g PF12353.3 EFE40647.1 - 0.17 11.8 7.2 0.19 11.6 5.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G TMEM154 PF15102.1 EFE40647.1 - 0.21 11.3 3.8 0.28 10.8 2.6 1.3 1 1 0 1 1 1 0 TMEM154 protein family FancD2 PF14631.1 EFE40647.1 - 0.57 7.2 4.7 0.64 7.0 3.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Senescence_reg PF04520.8 EFE40647.1 - 0.68 10.4 4.7 0.76 10.2 3.3 1.0 1 0 0 1 1 1 0 Senescence regulator Tankyrase_bdg_C PF15327.1 EFE40647.1 - 0.73 9.9 7.5 0.78 9.9 5.2 1.0 1 0 0 1 1 1 0 Tankyrase binding protein C terminal domain Mucin PF01456.12 EFE40647.1 - 0.93 9.2 9.6 1.1 9.0 6.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Nop25 PF09805.4 EFE40647.1 - 0.97 9.5 11.3 1.1 9.3 7.9 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) TRAP_alpha PF03896.11 EFE40647.1 - 1.1 8.2 3.5 1.2 8.0 2.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PGA2 PF07543.7 EFE40647.1 - 1.1 9.0 7.8 1.4 8.7 5.4 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF1754 PF08555.5 EFE40647.1 - 2 9.0 9.0 2.5 8.7 6.2 1.2 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) DDRGK PF09756.4 EFE40647.1 - 3.1 7.1 9.0 3.5 6.9 6.3 1.1 1 0 0 1 1 1 0 DDRGK domain NPR3 PF03666.8 EFE40647.1 - 3.1 6.2 7.4 3.5 6.0 5.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 XRCC4 PF06632.7 EFE40647.1 - 3.4 6.4 8.8 4.2 6.1 6.1 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF1675 PF07897.6 EFE40647.1 - 3.9 7.2 7.5 4.3 7.1 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) DUF3449 PF11931.3 EFE40647.1 - 4.5 6.7 5.8 4.8 6.6 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) RNA_pol_3_Rpc31 PF11705.3 EFE40647.1 - 5.3 6.9 9.3 5.7 6.8 6.4 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Daxx PF03344.10 EFE40647.1 - 5.5 5.3 11.8 6.4 5.1 8.2 1.0 1 0 0 1 1 1 0 Daxx Family DUF1510 PF07423.6 EFE40647.1 - 6.4 6.0 9.6 7.3 5.8 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SR-25 PF10500.4 EFE40649.1 - 1.3e-05 24.8 4.0 1.5e-05 24.5 2.8 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF2457 PF10446.4 EFE40649.1 - 0.00051 18.9 7.7 0.00057 18.7 5.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Daxx PF03344.10 EFE40649.1 - 0.002 16.7 14.8 0.0025 16.4 10.2 1.0 1 0 0 1 1 1 1 Daxx Family TRAP_alpha PF03896.11 EFE40649.1 - 0.0031 16.5 6.8 0.0043 16.1 4.7 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit PPP4R2 PF09184.6 EFE40649.1 - 0.0078 15.7 15.2 0.0096 15.4 10.5 1.1 1 0 0 1 1 1 1 PPP4R2 DUF4337 PF14235.1 EFE40649.1 - 0.036 13.9 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Zip PF02535.17 EFE40649.1 - 0.042 12.8 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SDA1 PF05285.7 EFE40649.1 - 0.052 12.8 11.9 0.062 12.5 8.3 1.1 1 0 0 1 1 1 0 SDA1 Prog_receptor PF02161.10 EFE40649.1 - 0.07 11.9 7.4 0.083 11.7 5.1 1.1 1 0 0 1 1 1 0 Progesterone receptor Cytomega_UL20A PF05984.7 EFE40649.1 - 0.088 13.0 3.7 0.16 12.2 2.6 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein DUF2722 PF10846.3 EFE40649.1 - 0.097 11.6 3.3 0.11 11.4 2.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Nop14 PF04147.7 EFE40649.1 - 0.1 10.5 15.4 0.11 10.4 10.7 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.7 EFE40649.1 - 0.13 11.9 9.8 0.2 11.3 6.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SAPS PF04499.10 EFE40649.1 - 0.16 10.5 2.1 0.18 10.4 1.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein IFT57 PF10498.4 EFE40649.1 - 0.27 9.9 6.8 0.34 9.6 4.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Vfa1 PF08432.5 EFE40649.1 - 0.33 10.9 5.8 0.41 10.6 4.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Spore_coat_CotO PF14153.1 EFE40649.1 - 0.36 10.2 5.4 0.41 10.0 3.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Sigma70_ner PF04546.8 EFE40649.1 - 0.39 10.2 10.1 0.52 9.8 7.0 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF1510 PF07423.6 EFE40649.1 - 0.42 9.9 9.9 0.51 9.6 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDHD PF02862.12 EFE40649.1 - 0.54 10.0 3.7 0.72 9.6 2.6 1.2 1 0 0 1 1 1 0 DDHD domain Merozoite_SPAM PF07133.6 EFE40649.1 - 0.55 10.1 20.5 0.74 9.6 14.2 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CobT PF06213.7 EFE40649.1 - 0.57 9.2 12.9 0.72 8.9 9.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mpp10 PF04006.7 EFE40649.1 - 0.81 7.9 15.7 0.96 7.7 10.9 1.1 1 0 0 1 1 1 0 Mpp10 protein BSP_II PF05432.6 EFE40649.1 - 0.84 8.8 14.3 1.4 8.1 9.9 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TFIIA PF03153.8 EFE40649.1 - 0.85 9.4 9.1 0.93 9.3 6.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NESP55 PF06390.7 EFE40649.1 - 1.1 8.5 11.6 1.4 8.2 8.0 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) NPR3 PF03666.8 EFE40649.1 - 1.9 6.9 4.8 2.3 6.6 3.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 YqfQ PF14181.1 EFE40649.1 - 2 8.4 4.6 3.2 7.7 3.2 1.3 1 0 0 1 1 1 0 YqfQ-like protein Pox_RNA_Pol_19 PF05320.7 EFE40649.1 - 2.1 8.0 8.9 3.9 7.1 6.2 1.5 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit VID27 PF08553.5 EFE40649.1 - 2.4 6.2 8.9 2.6 6.1 6.2 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein BUD22 PF09073.5 EFE40649.1 - 2.8 6.9 13.9 3.4 6.6 9.6 1.1 1 0 0 1 1 1 0 BUD22 Radial_spoke PF04712.7 EFE40649.1 - 2.9 6.5 8.7 3.4 6.2 6.0 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein NOA36 PF06524.7 EFE40649.1 - 2.9 7.0 10.8 3.6 6.7 7.5 1.2 1 0 0 1 1 1 0 NOA36 protein DUF740 PF05340.7 EFE40649.1 - 3.5 5.8 10.6 4.2 5.6 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) CDC45 PF02724.9 EFE40649.1 - 3.5 5.5 11.6 3.9 5.3 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Upf2 PF04050.9 EFE40649.1 - 4.2 7.1 17.6 6 6.6 12.2 1.2 1 0 0 1 1 1 0 Up-frameshift suppressor 2 DUF2890 PF11081.3 EFE40649.1 - 4.5 7.2 16.7 7.1 6.6 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Tom37_C PF11801.3 EFE40649.1 - 8 6.3 8.8 4 7.2 4.5 1.5 1 1 1 2 2 2 0 Tom37 C-terminal domain HSP90 PF00183.13 EFE40649.1 - 9.5 4.4 13.3 12 4.1 9.2 1.1 1 0 0 1 1 1 0 Hsp90 protein AAA_2 PF07724.9 EFE40651.1 - 4.3e-44 150.4 0.0 2.8e-42 144.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 EFE40651.1 - 2.5e-26 92.4 0.0 6.5e-15 55.4 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 EFE40651.1 - 3.2e-22 78.2 0.1 1.2e-21 76.3 0.0 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.1 EFE40651.1 - 2e-16 60.5 3.9 1.1e-05 25.5 0.0 5.6 3 2 3 6 6 6 2 AAA ATPase domain AAA_5 PF07728.9 EFE40651.1 - 4.5e-15 55.5 1.1 3.8e-08 33.1 0.0 3.9 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFE40651.1 - 2.2e-13 50.4 0.2 0.00011 22.4 0.0 3.8 2 2 1 3 3 3 2 AAA domain Sigma54_activat PF00158.21 EFE40651.1 - 7.4e-09 35.2 0.0 7.1e-05 22.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.1 EFE40651.1 - 1.2e-08 35.7 0.5 0.0053 17.5 0.0 3.6 3 0 0 3 3 3 2 AAA domain Clp_N PF02861.15 EFE40651.1 - 6.1e-08 32.4 4.2 0.0014 18.4 0.1 4.3 5 0 0 5 5 3 1 Clp amino terminal domain AAA_18 PF13238.1 EFE40651.1 - 9.6e-08 32.3 0.0 0.0074 16.6 0.0 3.6 3 0 0 3 3 2 2 AAA domain AAA_19 PF13245.1 EFE40651.1 - 1.9e-07 30.7 0.0 0.013 15.2 0.0 3.0 2 0 0 2 2 2 2 Part of AAA domain IstB_IS21 PF01695.12 EFE40651.1 - 2e-07 30.5 0.0 0.026 13.9 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein Arch_ATPase PF01637.13 EFE40651.1 - 8.3e-06 25.6 6.8 0.026 14.1 0.0 5.1 7 0 0 7 7 5 2 Archaeal ATPase AAA_28 PF13521.1 EFE40651.1 - 1.1e-05 25.4 0.4 0.5 10.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain MobB PF03205.9 EFE40651.1 - 1.9e-05 24.4 0.0 0.094 12.4 0.0 2.8 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 EFE40651.1 - 1.9e-05 24.5 0.0 0.17 11.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EFE40651.1 - 3.4e-05 23.9 0.0 0.47 10.6 0.0 2.7 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.16 EFE40651.1 - 3.9e-05 22.9 0.0 0.12 11.5 0.0 3.4 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 EFE40651.1 - 6.4e-05 22.1 0.1 0.12 11.4 0.0 3.6 4 0 0 4 4 3 1 Zeta toxin AAA_3 PF07726.6 EFE40651.1 - 8.5e-05 22.1 0.0 0.88 9.1 0.0 3.4 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.18 EFE40651.1 - 0.00017 21.5 0.1 0.0021 17.9 0.0 2.8 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_25 PF13481.1 EFE40651.1 - 0.00027 20.3 0.0 1.4 8.2 0.0 3.3 2 1 0 3 3 3 2 AAA domain ABC_tran PF00005.22 EFE40651.1 - 0.00032 21.0 0.2 0.78 10.0 0.0 3.2 3 0 0 3 3 2 1 ABC transporter AAA_10 PF12846.2 EFE40651.1 - 0.00065 19.2 0.9 0.25 10.7 0.0 4.0 3 2 1 4 4 4 1 AAA-like domain T2SE PF00437.15 EFE40651.1 - 0.00068 18.6 0.0 0.031 13.1 0.0 2.5 2 1 0 2 2 2 1 Type II/IV secretion system protein NTPase_1 PF03266.10 EFE40651.1 - 0.001 18.8 0.1 0.095 12.4 0.0 3.3 3 0 0 3 3 3 1 NTPase DUF258 PF03193.11 EFE40651.1 - 0.0011 18.2 0.0 0.43 9.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Torsin PF06309.6 EFE40651.1 - 0.0013 18.6 0.0 0.0049 16.7 0.0 1.8 2 0 0 2 2 2 1 Torsin AAA_29 PF13555.1 EFE40651.1 - 0.0017 17.8 0.0 1.3 8.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain ResIII PF04851.10 EFE40651.1 - 0.0019 18.0 0.0 0.39 10.5 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_24 PF13479.1 EFE40651.1 - 0.0022 17.5 0.0 2.2 7.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EFE40651.1 - 0.0033 17.1 0.0 0.24 11.0 0.0 2.6 2 0 0 2 2 2 1 NACHT domain SRP54 PF00448.17 EFE40651.1 - 0.0071 15.8 0.0 1.2 8.4 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_21 PF13304.1 EFE40651.1 - 0.025 14.5 0.0 1.8 8.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 EFE40651.1 - 0.042 13.4 0.0 11 5.6 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ATP_bind_1 PF03029.12 EFE40651.1 - 0.1 12.1 0.1 17 4.8 0.0 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.1 EFE40651.1 - 1.4 9.1 0.0 1.4 9.1 0.0 4.4 4 1 0 4 4 3 0 AAA domain SNF2_N PF00176.18 EFE40652.1 - 1.5e-67 227.4 0.0 2.1e-67 227.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE40652.1 - 3.4e-12 46.0 0.0 6.8e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE40652.1 - 0.00038 20.3 0.0 0.0024 17.7 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit EBP PF05241.7 EFE40653.1 - 4.1e-57 192.3 10.4 8.2e-57 191.3 7.2 1.4 1 1 0 1 1 1 1 Emopamil binding protein DUF4484 PF14831.1 EFE40654.1 - 1.7e-51 174.8 2.1 2.6e-51 174.2 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) DUF2347 PF09804.4 EFE40654.1 - 2.3e-49 168.1 0.0 4.3e-49 167.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.5 EFE40654.1 - 0.0045 16.6 0.0 0.0089 15.7 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Barttin PF15462.1 EFE40654.1 - 0.0077 15.9 2.5 0.018 14.7 1.8 1.5 1 0 0 1 1 1 1 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Avl9 PF09794.4 EFE40654.1 - 0.039 12.4 0.0 0.048 12.1 0.0 1.2 1 0 0 1 1 1 0 Transport protein Avl9 Spc7 PF08317.6 EFE40655.1 - 0.41 9.2 13.2 0.74 8.4 9.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Bacillus_HBL PF05791.6 EFE40655.1 - 1.4 8.2 7.7 0.18 11.1 2.4 1.6 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF342 PF03961.8 EFE40655.1 - 5.3 5.3 8.4 8.5 4.6 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Tubulin_3 PF14881.1 EFE40656.1 - 8.8e-83 276.1 0.1 1.6e-82 275.3 0.1 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 EFE40656.1 - 5.3e-41 139.2 0.0 1.3e-40 138.0 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 EFE40656.1 - 4.5e-07 29.9 0.0 0.0038 17.0 0.0 2.3 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain PP2C PF00481.16 EFE40657.1 - 3.8e-60 203.4 0.1 3.7e-52 177.2 0.0 3.2 2 1 0 2 2 2 2 Protein phosphatase 2C Nop14 PF04147.7 EFE40657.1 - 0.37 8.6 3.2 0.5 8.2 2.2 1.1 1 0 0 1 1 1 0 Nop14-like family CUE PF02845.11 EFE40659.1 - 2.6e-11 42.7 0.0 4.7e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 CUE domain eRF1_2 PF03464.10 EFE40659.1 - 0.077 13.3 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 eRF1 domain 2 OB_NTP_bind PF07717.11 EFE40660.1 - 2e-22 79.1 0.0 3.7e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFE40660.1 - 8.7e-21 73.8 0.0 1.9e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE40660.1 - 1.7e-12 46.9 0.0 5.1e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE40660.1 - 3.3e-05 23.4 0.1 8.7e-05 22.0 0.1 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFE40660.1 - 0.00014 21.9 0.1 0.00043 20.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 EFE40660.1 - 0.011 14.6 0.0 0.03 13.2 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 EFE40660.1 - 0.013 15.1 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 EFE40660.1 - 0.024 14.1 0.1 0.15 11.4 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 EFE40660.1 - 0.048 13.9 0.0 0.16 12.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.1 EFE40660.1 - 0.054 13.3 0.1 0.33 10.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EFE40660.1 - 0.073 12.8 0.2 0.18 11.5 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain Zeta_toxin PF06414.7 EFE40660.1 - 0.084 11.9 0.1 0.25 10.4 0.0 1.8 1 1 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 EFE40660.1 - 0.12 12.3 0.0 2.9 7.7 0.0 2.5 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EFE40660.1 - 0.22 11.8 0.0 0.38 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain PITH PF06201.8 EFE40661.1 - 1.5e-27 96.2 0.0 8.5e-14 51.5 0.0 2.1 1 1 1 2 2 2 2 PITH domain Snf7 PF03357.16 EFE40662.1 - 3.9e-30 104.4 9.5 4.7e-30 104.2 6.6 1.1 1 0 0 1 1 1 1 Snf7 HSCB_C PF07743.8 EFE40662.1 - 0.032 14.6 8.8 1.8 9.1 0.3 2.6 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain DHDPS PF00701.17 EFE40662.1 - 0.096 11.2 0.4 0.19 10.2 0.2 1.5 1 1 0 1 1 1 0 Dihydrodipicolinate synthetase family MtaB PF12176.3 EFE40662.1 - 0.12 10.7 3.1 1.5 7.1 0.1 2.1 2 0 0 2 2 2 0 Methanol-cobalamin methyltransferase B subunit Adhes-Ig_like PF09085.5 EFE40662.1 - 0.38 10.6 1.9 1.3 8.8 1.3 2.0 1 1 0 1 1 1 0 Adhesion molecule, immunoglobulin-like DUF2203 PF09969.4 EFE40662.1 - 1.6 8.9 6.4 1.7 8.8 0.4 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Nsp1_C PF05064.8 EFE40662.1 - 8.7 6.0 10.2 0.17 11.5 1.3 2.3 3 0 0 3 3 3 0 Nsp1-like C-terminal region AAA PF00004.24 EFE40663.1 - 3.1e-91 302.4 0.0 1e-45 155.1 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFE40663.1 - 1.9e-13 50.8 0.7 6.7e-05 22.9 0.0 4.3 3 2 1 4 4 3 2 AAA ATPase domain RuvB_N PF05496.7 EFE40663.1 - 6.6e-13 48.2 0.0 5.2e-06 25.6 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFE40663.1 - 7.2e-12 45.5 0.1 0.0042 17.2 0.0 5.2 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.1 EFE40663.1 - 7.4e-11 42.1 0.0 3.2e-05 23.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_2 PF07724.9 EFE40663.1 - 8.6e-11 42.0 0.0 0.00028 20.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 EFE40663.1 - 1.2e-10 42.2 0.0 5.7e-05 23.9 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.9 EFE40663.1 - 5e-10 39.2 0.4 0.0012 18.6 0.0 4.1 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EFE40663.1 - 5.3e-10 38.7 0.0 0.00044 19.4 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_14 PF13173.1 EFE40663.1 - 2.2e-09 37.2 0.0 0.002 18.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 EFE40663.1 - 3.5e-09 35.8 0.3 0.00011 21.0 0.0 2.6 3 0 0 3 3 3 2 TIP49 C-terminus AAA_19 PF13245.1 EFE40663.1 - 5.1e-08 32.5 1.6 0.0072 16.0 0.1 3.5 2 2 0 2 2 2 2 Part of AAA domain RNA_helicase PF00910.17 EFE40663.1 - 5.4e-08 32.9 0.0 0.0053 16.9 0.0 2.7 2 1 0 2 2 2 2 RNA helicase AAA_28 PF13521.1 EFE40663.1 - 1.3e-07 31.6 0.0 0.0029 17.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 EFE40663.1 - 2.4e-07 30.3 0.5 0.027 13.9 0.0 2.7 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.1 EFE40663.1 - 4e-07 30.3 0.1 0.015 15.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.16 EFE40663.1 - 6.4e-07 28.7 1.7 0.019 14.0 0.0 2.7 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EFE40663.1 - 7.3e-07 28.8 0.0 0.0025 17.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EFE40663.1 - 1.9e-06 27.6 0.3 0.12 11.9 0.0 3.8 3 1 1 4 4 3 2 NACHT domain AAA_25 PF13481.1 EFE40663.1 - 6.3e-06 25.7 4.2 1.7 7.9 0.0 4.5 2 2 1 4 4 4 2 AAA domain Cytidylate_kin2 PF13189.1 EFE40663.1 - 3.2e-05 23.9 0.0 0.0085 16.0 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family ABC_tran PF00005.22 EFE40663.1 - 4.2e-05 23.8 0.0 0.15 12.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter Sigma54_activ_2 PF14532.1 EFE40663.1 - 5.1e-05 23.3 0.0 0.44 10.5 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain KaiC PF06745.8 EFE40663.1 - 7e-05 22.0 0.1 0.55 9.3 0.0 3.2 2 1 1 3 3 3 2 KaiC Sigma54_activat PF00158.21 EFE40663.1 - 7.9e-05 22.1 0.0 0.33 10.3 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain PhoH PF02562.11 EFE40663.1 - 8.5e-05 21.8 0.0 0.2 10.8 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein Arch_ATPase PF01637.13 EFE40663.1 - 9.2e-05 22.2 0.0 2.2 7.8 0.0 3.7 2 2 1 3 3 3 2 Archaeal ATPase SKI PF01202.17 EFE40663.1 - 0.00012 22.0 0.0 0.37 10.6 0.0 2.6 2 0 0 2 2 2 2 Shikimate kinase AFG1_ATPase PF03969.11 EFE40663.1 - 0.00039 19.3 0.0 0.14 10.9 0.0 2.7 2 1 0 2 2 2 1 AFG1-like ATPase ResIII PF04851.10 EFE40663.1 - 0.00048 19.9 0.0 1 9.1 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit NB-ARC PF00931.17 EFE40663.1 - 0.00053 18.9 0.0 0.27 10.0 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Rad17 PF03215.10 EFE40663.1 - 0.00057 18.6 0.0 0.26 9.9 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein Viral_helicase1 PF01443.13 EFE40663.1 - 0.00071 19.1 0.0 0.5 9.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF815 PF05673.8 EFE40663.1 - 0.0013 17.6 0.0 0.046 12.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Parvo_NS1 PF01057.12 EFE40663.1 - 0.0017 17.3 0.0 1.4 7.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 UPF0079 PF02367.12 EFE40663.1 - 0.0035 16.9 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 MSA-2c PF12238.3 EFE40663.1 - 0.004 16.8 0.6 0.013 15.1 0.4 1.8 1 1 0 1 1 1 1 Merozoite surface antigen 2c ATP-synt_ab PF00006.20 EFE40663.1 - 0.0045 16.5 0.0 0.8 9.1 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_11 PF13086.1 EFE40663.1 - 0.0046 16.5 0.0 1.6 8.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 EFE40663.1 - 0.014 15.0 0.1 1.5 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain CPT PF07931.7 EFE40663.1 - 0.016 14.8 0.0 0.4 10.3 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_23 PF13476.1 EFE40663.1 - 0.019 15.3 1.0 3.2 8.0 0.0 3.2 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.10 EFE40663.1 - 0.021 14.5 0.0 3.5 7.2 0.0 2.9 2 1 0 3 3 3 0 NTPase IPT PF01745.11 EFE40663.1 - 0.049 12.7 0.1 6.3 5.8 0.0 2.6 3 0 0 3 3 2 0 Isopentenyl transferase DUF2075 PF09848.4 EFE40663.1 - 0.073 12.0 0.0 4.6 6.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_10 PF12846.2 EFE40663.1 - 1 8.7 3.4 22 4.3 0.0 3.8 5 1 0 5 5 4 0 AAA-like domain BOP1NT PF08145.7 EFE40664.1 - 7.9e-106 353.5 7.0 1.2e-105 353.0 4.9 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 EFE40664.1 - 9e-27 91.9 11.4 2.5e-11 43.0 0.2 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat Leo1 PF04004.8 EFE40666.1 - 1.6e-33 115.8 0.0 1.6e-33 115.8 0.0 2.0 2 0 0 2 2 2 1 Leo1-like protein EF-1_beta_acid PF10587.4 EFE40666.1 - 0.035 14.2 2.1 0.035 14.2 1.4 6.6 6 1 0 6 6 6 0 Eukaryotic elongation factor 1 beta central acidic region Nucleoplasmin PF03066.10 EFE40667.1 - 0.92 9.0 8.2 0.79 9.2 5.7 1.0 1 0 0 1 1 1 0 Nucleoplasmin BSP_II PF05432.6 EFE40667.1 - 1.4 8.1 10.1 1.3 8.2 7.0 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) FAM176 PF14851.1 EFE40667.1 - 2.1 8.0 7.1 1.9 8.1 4.9 1.0 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.5 EFE40667.1 - 2.3 8.4 6.4 2.5 8.3 4.4 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Merozoite_SPAM PF07133.6 EFE40667.1 - 2.9 7.7 12.4 2.8 7.8 8.6 1.0 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Spore_coat_CotO PF14153.1 EFE40667.1 - 5.8 6.3 10.2 6.5 6.1 7.1 1.0 1 0 0 1 1 1 0 Spore coat protein CotO Menin PF05053.8 EFE40667.1 - 5.9 4.9 6.1 5.8 4.9 4.2 1.0 1 0 0 1 1 1 0 Menin PBP1_TM PF14812.1 EFE40667.1 - 6.4 7.1 7.5 7 7.0 5.2 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleo_P87 PF07267.6 EFE40667.1 - 6.9 5.2 9.4 6.5 5.3 6.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Mob1_phocein PF03637.12 EFE40668.1 - 2e-29 102.5 1.7 6.1e-14 52.0 0.2 2.3 2 0 0 2 2 2 2 Mob1/phocein family IF-2B PF01008.12 EFE40669.1 - 1.3e-56 191.7 7.0 2.2e-46 158.0 1.9 3.0 2 1 0 2 2 2 2 Initiation factor 2 subunit family Ribosom_S12_S23 PF00164.20 EFE40670.1 - 2.7e-40 136.5 0.6 3.1e-40 136.3 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 THUMP PF02926.12 EFE40671.1 - 0.024 14.4 0.7 0.037 13.9 0.5 1.2 1 0 0 1 1 1 0 THUMP domain YqaJ PF09588.5 EFE40672.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain Ribosomal_L17 PF01196.14 EFE40673.1 - 1.3e-33 115.4 0.0 2.5e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L17 Metallophos_2 PF12850.2 EFE40674.1 - 2.2e-16 60.0 0.0 2.8e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EFE40674.1 - 0.063 12.6 0.1 5.9 6.2 0.0 2.1 1 1 1 2 2 2 0 Calcineurin-like phosphoesterase DUF202 PF02656.10 EFE40676.1 - 6.4e-13 48.7 4.5 6.4e-13 48.7 3.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4234 PF14018.1 EFE40676.1 - 0.018 14.7 0.8 0.034 13.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) DUF2207 PF09972.4 EFE40676.1 - 0.05 12.1 0.7 0.05 12.1 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2615 PF11027.3 EFE40676.1 - 0.3 11.0 1.7 0.6 10.0 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) Tctex-1 PF03645.8 EFE40677.1 - 2.4e-19 69.0 0.0 2.9e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family DERM PF14704.1 EFE40677.1 - 0.058 13.3 0.1 0.083 12.8 0.1 1.2 1 0 0 1 1 1 0 Dermatopontin WD40 PF00400.27 EFE40678.1 - 5.5e-41 137.0 21.0 2e-11 43.3 0.2 8.1 9 0 0 9 9 9 5 WD domain, G-beta repeat Nup160 PF11715.3 EFE40678.1 - 5.2e-07 28.1 0.5 0.08 11.0 0.0 4.1 4 0 0 4 4 4 4 Nucleoporin Nup120/160 Filament PF00038.16 EFE40679.1 - 0.017 14.6 0.4 0.027 13.9 0.3 1.2 1 0 0 1 1 1 0 Intermediate filament protein ketoacyl-synt PF00109.21 EFE40680.1 - 2.5e-76 256.5 0.0 4.7e-76 255.6 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EFE40680.1 - 1.3e-33 115.3 0.2 3.9e-33 113.8 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 EFE40680.1 - 1.9e-31 109.6 0.2 6.1e-24 84.9 0.0 2.3 1 1 1 2 2 2 2 Acyl transferase domain Thioesterase PF00975.15 EFE40680.1 - 3.5e-30 105.9 0.0 6.8e-30 104.9 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain PS-DH PF14765.1 EFE40680.1 - 1.3e-14 54.0 0.0 2.9e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.20 EFE40680.1 - 1.7e-11 44.1 8.2 7.1e-06 26.1 0.3 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Abhydrolase_6 PF12697.2 EFE40680.1 - 4.9e-05 23.3 0.0 0.00017 21.5 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thiolase_N PF00108.18 EFE40680.1 - 0.00062 18.8 0.0 0.0014 17.6 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_3 PF07859.8 EFE40680.1 - 0.045 13.3 0.0 0.17 11.4 0.0 2.0 1 0 0 1 1 1 0 alpha/beta hydrolase fold Herpes_LAMP2 PF06126.6 EFE40680.1 - 0.59 8.4 2.2 0.97 7.7 1.5 1.2 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 FMO-like PF00743.14 EFE40681.1 - 3.3e-40 137.7 0.0 4.1e-40 137.4 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFE40681.1 - 8.3e-14 52.1 0.1 1.6e-12 47.9 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE40681.1 - 3.5e-07 29.4 0.8 1.8e-06 27.1 0.1 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.22 EFE40681.1 - 0.15 12.4 0.2 0.31 11.4 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.20 EFE40682.1 - 2.8e-18 66.3 2.8 2.1e-16 60.2 1.9 2.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE40682.1 - 1.1e-08 35.2 0.0 0.00035 20.4 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE40682.1 - 2.6e-08 33.7 0.0 6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 EFE40682.1 - 0.0075 15.2 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Pyr_redox PF00070.22 EFE40682.1 - 0.052 13.9 1.2 0.13 12.7 0.8 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Epimerase PF01370.16 EFE40682.1 - 0.069 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFE40682.1 - 0.09 12.7 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 NADH(P)-binding 3Beta_HSD PF01073.14 EFE40682.1 - 0.14 10.8 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_Gly3P_dh_N PF01210.18 EFE40682.1 - 0.14 11.8 0.1 0.35 10.5 0.0 1.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Fasciclin PF02469.17 EFE40683.1 - 3.3e-36 124.1 0.0 9.7e-23 80.5 0.2 2.2 2 0 0 2 2 2 2 Fasciclin domain Cu-oxidase_2 PF07731.9 EFE40684.1 - 4.3e-21 74.8 2.2 7e-21 74.1 0.4 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.17 EFE40684.1 - 1.5e-18 67.1 0.0 3.9e-18 65.8 0.0 1.7 1 1 0 1 1 1 1 Multicopper oxidase Methyltransf_2 PF00891.13 EFE40685.1 - 5e-38 130.6 0.0 6.6e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 EFE40685.1 - 0.029 14.0 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 EFE40685.1 - 0.04 14.4 0.0 0.17 12.4 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40685.1 - 0.1 13.0 0.0 0.45 11.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Uds1 PF15456.1 EFE40687.1 - 1.1e-31 109.4 4.2 1.9e-31 108.6 2.9 1.4 1 0 0 1 1 1 1 Up-regulated During Septation Spc7 PF08317.6 EFE40687.1 - 0.021 13.5 0.2 0.03 12.9 0.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.17 EFE40687.1 - 0.079 12.9 1.7 7 6.7 0.0 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain GrpE PF01025.14 EFE40688.1 - 2.2e-44 150.9 3.7 3e-44 150.4 2.6 1.2 1 0 0 1 1 1 1 GrpE PEARLI-4 PF05278.7 EFE40688.1 - 0.026 13.8 2.5 0.04 13.3 1.7 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) TPD52 PF04201.10 EFE40688.1 - 0.033 13.9 1.6 0.051 13.2 1.1 1.4 1 0 0 1 1 1 0 Tumour protein D52 family Focal_AT PF03623.8 EFE40688.1 - 0.07 12.6 0.0 0.24 10.8 0.0 1.6 1 1 0 1 1 1 0 Focal adhesion targeting region Phage_GP20 PF06810.6 EFE40688.1 - 0.24 10.8 7.1 0.62 9.4 4.9 1.7 1 1 0 1 1 1 0 Phage minor structural protein GP20 Bap31 PF05529.7 EFE40688.1 - 0.57 9.6 4.4 0.47 9.8 2.3 1.4 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like tRNA-synt_2d PF01409.15 EFE40689.1 - 1.3e-47 162.0 0.0 9.1e-27 93.8 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 EFE40689.1 - 4.8e-23 81.1 0.0 1.2e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain EFP_N PF08207.7 EFE40689.1 - 0.12 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain RRM_1 PF00076.17 EFE40690.1 - 4.3e-16 58.3 0.0 5.8e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40690.1 - 4.1e-11 42.6 0.0 5.8e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE40690.1 - 4.1e-09 36.1 0.0 5.8e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 EFE40691.1 - 2.2e-16 59.0 7.8 3e-05 23.7 0.0 6.6 5 1 1 6 6 6 5 WD domain, G-beta repeat SRA1 PF07304.6 EFE40691.1 - 7.2e-13 48.5 0.0 3.7e-12 46.2 0.0 2.3 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.2 EFE40691.1 - 0.00023 21.0 0.2 0.0015 18.3 0.1 2.0 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Prp18 PF02840.10 EFE40691.1 - 0.0094 15.7 0.2 0.088 12.6 0.0 2.5 2 0 0 2 2 2 1 Prp18 domain Transp_cyt_pur PF02133.10 EFE40692.1 - 1.2e-21 76.7 34.1 1.8e-10 39.9 22.0 2.8 2 1 0 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1418 PF07214.7 EFE40692.1 - 1.6 8.4 5.4 2.6 7.7 1.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) ATE_C PF04377.10 EFE40693.1 - 5.5e-26 91.1 2.5 4.2e-25 88.2 1.8 2.1 1 1 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus MFS_1 PF07690.11 EFE40694.1 - 1.7e-40 138.8 46.3 5.5e-40 137.1 32.1 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40694.1 - 3.6e-11 42.3 33.2 4.2e-10 38.8 5.8 3.5 2 1 0 2 2 2 2 Sugar (and other) transporter Bcl-2 PF00452.14 EFE40694.1 - 0.12 12.5 0.1 6.3 6.9 0.0 2.6 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Fungal_trans PF04082.13 EFE40696.1 - 7.2e-06 25.0 0.5 1.4e-05 24.1 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain FAD_binding_4 PF01565.18 EFE40697.1 - 8.7e-18 64.1 1.5 1.7e-17 63.1 1.1 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE40697.1 - 3.9e-06 26.6 0.0 9.4e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like AflR PF08493.5 EFE40698.1 - 8e-06 25.0 4.3 8e-06 25.0 3.0 2.1 1 1 1 2 2 2 1 Aflatoxin regulatory protein AMOP PF03782.12 EFE40698.1 - 0.035 14.0 0.6 0.035 14.0 0.4 1.8 2 0 0 2 2 2 0 AMOP domain p450 PF00067.17 EFE40699.1 - 2.3e-25 89.0 0.0 9.2e-23 80.4 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 adh_short PF00106.20 EFE40700.1 - 7.8e-35 120.2 3.0 7.8e-35 120.2 2.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE40700.1 - 4.3e-26 92.1 0.6 7.8e-26 91.3 0.4 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE40700.1 - 5.3e-18 65.3 0.8 7.3e-18 64.8 0.5 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 EFE40700.1 - 0.004 16.8 0.8 0.0062 16.1 0.6 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_26 PF13659.1 EFE40700.1 - 0.019 15.0 0.1 0.038 14.0 0.1 1.5 1 1 0 1 1 1 0 Methyltransferase domain AdoHcyase_NAD PF00670.16 EFE40700.1 - 0.027 14.3 0.4 0.074 12.8 0.3 1.7 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Epimerase PF01370.16 EFE40700.1 - 0.063 12.7 0.2 0.086 12.2 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EFE40700.1 - 0.083 11.7 0.6 0.27 10.0 0.4 1.9 1 1 0 1 1 1 0 RmlD substrate binding domain TrkA_N PF02254.13 EFE40700.1 - 0.11 12.4 0.4 0.27 11.2 0.1 1.8 2 0 0 2 2 2 0 TrkA-N domain HlyIII PF03006.15 EFE40701.1 - 3.6e-59 199.8 14.6 4.4e-59 199.5 10.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related SAC3_GANP PF03399.11 EFE40702.1 - 0.0059 16.1 0.1 0.0093 15.5 0.1 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family DUF4129 PF13559.1 EFE40702.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) TPR_19 PF14559.1 EFE40703.1 - 1.5e-06 28.4 0.0 0.0014 18.9 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 EFE40703.1 - 0.023 15.1 0.0 14 6.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFE40703.1 - 0.027 14.3 0.2 1.9 8.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFE40703.1 - 0.046 13.3 0.0 0.66 9.6 0.0 2.6 1 1 1 2 2 2 0 TPR repeat TPR_16 PF13432.1 EFE40703.1 - 0.059 14.0 0.0 4.9 7.9 0.0 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.21 EFE40704.1 - 3.6e-34 117.8 0.0 4.4e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EFE40704.1 - 1.8e-15 57.3 0.0 2.4e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EFE40704.1 - 2.4e-10 39.9 0.0 4.7e-10 39.0 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EFE40704.1 - 0.0003 20.1 0.0 0.00041 19.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 DUF1749 PF08538.5 EFE40705.1 - 8.4e-89 297.4 0.0 1e-88 297.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 EFE40705.1 - 7.8e-05 22.6 0.0 0.00012 22.0 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE40705.1 - 8.3e-05 22.3 0.0 0.00017 21.3 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.8 EFE40705.1 - 0.00042 19.9 0.1 0.015 14.8 0.0 2.8 3 0 0 3 3 3 1 Serine hydrolase Abhydrolase_3 PF07859.8 EFE40705.1 - 0.013 15.1 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Vps35 PF03635.12 EFE40708.1 - 4.6e-294 977.4 0.0 1.1e-169 566.0 0.1 2.0 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 35 DUF2346 PF09803.4 EFE40709.1 - 0.0064 16.3 0.2 0.0089 15.8 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2346) NST1 PF13945.1 EFE40710.1 - 1.1e-72 244.0 2.0 1.1e-72 244.0 1.4 4.8 4 1 1 5 5 5 2 Salt tolerance down-regulator PRKCSH_1 PF13015.1 EFE40713.1 - 2.9e-31 108.0 0.4 8.5e-31 106.5 0.3 1.7 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH-like PF12999.2 EFE40713.1 - 2.5e-20 72.7 4.9 4e-20 72.1 1.8 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH PF07915.8 EFE40713.1 - 3.8e-09 37.2 1.2 3.8e-09 37.2 0.8 1.9 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein DUF3450 PF11932.3 EFE40713.1 - 0.036 13.3 7.0 0.54 9.4 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Arteri_nucleo PF01481.11 EFE40713.1 - 0.053 13.6 0.2 0.86 9.7 0.0 2.5 2 1 0 2 2 2 0 Arterivirus nucleocapsid protein CorA PF01544.13 EFE40713.1 - 0.057 12.4 3.4 0.1 11.6 2.3 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein HMG_box PF00505.14 EFE40713.1 - 0.11 12.8 2.7 0.25 11.6 1.9 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box V_ATPase_I PF01496.14 EFE40713.1 - 0.48 8.2 3.3 0.86 7.3 2.3 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3584 PF12128.3 EFE40713.1 - 1.6 5.9 16.3 0.14 9.5 8.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF4407 PF14362.1 EFE40713.1 - 2.7 6.8 12.6 1.3 7.9 6.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Laminin_II PF06009.7 EFE40713.1 - 8.7 6.0 10.6 8.6 6.1 1.5 2.7 3 0 0 3 3 3 0 Laminin Domain II GrpE PF01025.14 EFE40713.1 - 9.4 5.7 14.9 6.6 6.2 6.9 2.5 2 1 0 2 2 2 0 GrpE DUF724 PF05266.9 EFE40713.1 - 9.9 5.7 10.8 3.6 7.1 4.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Rtf2 PF04641.7 EFE40714.1 - 3.2e-67 226.4 1.3 4e-67 226.1 0.9 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.3 EFE40714.1 - 2.8e-09 36.3 0.0 0.00054 19.4 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 EFE40714.1 - 4.6e-06 26.2 0.6 4.6e-06 26.2 0.4 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.1 EFE40714.1 - 0.0031 17.1 0.2 0.0063 16.2 0.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 EFE40714.1 - 0.0052 16.5 0.3 0.034 13.9 0.0 2.2 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFE40714.1 - 0.01 15.4 0.1 0.021 14.4 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Plasmodium_Vir PF05795.6 EFE40714.1 - 0.64 9.1 5.8 0.89 8.6 4.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ribosomal_L50 PF10501.4 EFE40715.1 - 5.5e-19 68.2 0.0 1.4e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 Ribosomal subunit 39S SAP PF02037.22 EFE40715.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 SAP domain DUF2458 PF10454.4 EFE40717.1 - 1.1e-34 119.4 2.6 1.6e-34 118.9 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) FAD_binding_2 PF00890.19 EFE40717.1 - 0.032 13.0 0.0 0.036 12.9 0.0 1.0 1 0 0 1 1 1 0 FAD binding domain DUF1168 PF06658.7 EFE40717.1 - 0.26 10.8 3.5 0.34 10.4 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DAHP_synth_1 PF00793.15 EFE40718.1 - 7.4e-97 323.2 0.0 8.8e-97 323.0 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Pex24p PF06398.6 EFE40721.1 - 1.5e-85 287.1 0.2 1.8e-85 286.9 0.1 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Pam16 PF03656.8 EFE40722.1 - 4.5e-36 123.4 0.2 5.4e-36 123.1 0.2 1.0 1 0 0 1 1 1 1 Pam16 Methyltransf_18 PF12847.2 EFE40723.1 - 9.9e-10 38.9 0.0 1.5e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40723.1 - 1.4e-09 37.9 0.0 1.8e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40723.1 - 3.7e-08 33.7 0.0 6e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE40723.1 - 1.8e-07 31.5 0.0 6.9e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain adh_short PF00106.20 EFE40723.1 - 3.6e-06 26.9 0.1 5.9e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_31 PF13847.1 EFE40723.1 - 6.8e-06 25.7 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE40723.1 - 0.00052 20.3 0.0 0.00088 19.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE40723.1 - 0.0011 18.3 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 EFE40723.1 - 0.0012 18.8 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain KR PF08659.5 EFE40723.1 - 0.0028 17.3 0.0 0.0042 16.7 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE40723.1 - 0.031 14.0 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase TPMT PF05724.6 EFE40723.1 - 0.049 13.0 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) DREV PF05219.7 EFE40723.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase FAT PF02259.18 EFE40725.1 - 6.4e-125 416.7 0.3 6.4e-125 416.7 0.2 1.8 2 0 0 2 2 2 1 FAT domain DUF3385 PF11865.3 EFE40725.1 - 5e-61 205.3 5.8 1.6e-58 197.1 1.1 3.8 3 0 0 3 3 3 2 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.22 EFE40725.1 - 1.5e-56 191.5 0.7 2.8e-56 190.6 0.5 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 EFE40725.1 - 1.1e-39 134.5 2.9 4.1e-39 132.7 0.1 3.6 3 0 0 3 3 3 1 Rapamycin binding domain HEAT_2 PF13646.1 EFE40725.1 - 2.2e-19 69.5 9.2 0.00014 22.1 0.0 8.7 7 3 3 10 10 10 6 HEAT repeats HEAT_EZ PF13513.1 EFE40725.1 - 1.9e-15 56.7 6.6 0.0011 19.3 0.0 12.0 10 1 3 13 13 13 3 HEAT-like repeat FATC PF02260.15 EFE40725.1 - 6.7e-15 54.2 0.2 1.6e-14 53.0 0.2 1.7 1 0 0 1 1 1 1 FATC domain HEAT PF02985.17 EFE40725.1 - 1.5e-13 49.5 19.9 0.16 12.1 0.0 11.7 13 0 0 13 13 13 5 HEAT repeat UME PF08064.8 EFE40725.1 - 0.00012 21.9 4.9 10 6.0 0.0 6.8 5 2 2 7 7 7 2 UME (NUC010) domain Mit_ribos_Mrp51 PF11709.3 EFE40726.1 - 7.7e-90 301.2 0.0 8.8e-90 301.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.13 EFE40727.1 - 5.5e-58 194.0 0.5 6.6e-58 193.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal S17 Cryptochrome_C PF12546.3 EFE40727.1 - 0.036 14.7 0.0 0.05 14.3 0.0 1.3 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal RPAP2_Rtr1 PF04181.8 EFE40728.1 - 2.4e-19 69.1 0.1 4.1e-19 68.4 0.1 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family SH3_2 PF07653.12 EFE40729.1 - 1.1e-10 40.7 0.0 2.4e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFE40729.1 - 3.7e-10 39.0 0.1 6.9e-10 38.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE40729.1 - 1.6e-09 37.2 0.1 4.5e-09 35.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain Adaptin_N PF01602.15 EFE40730.1 - 1e-125 420.1 7.3 1.3e-125 419.7 5.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EFE40730.1 - 7.1e-18 65.0 4.3 5.6e-17 62.1 0.4 3.1 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EFE40730.1 - 5.2e-17 61.9 5.4 6.9e-11 42.2 0.5 4.4 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 EFE40730.1 - 9.9e-11 40.7 4.7 0.0056 16.6 0.0 5.4 7 0 0 7 7 7 3 HEAT repeat Arm PF00514.18 EFE40730.1 - 2.9e-05 23.7 3.2 2.7 7.9 0.0 5.4 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 EFE40730.1 - 3e-05 23.6 0.1 0.71 9.6 0.0 4.4 4 0 0 4 4 4 2 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.3 EFE40730.1 - 0.0024 17.2 1.9 2.7 7.2 0.0 3.1 2 1 0 2 2 2 2 CLASP N terminal HEAT_EZ PF13513.1 EFE40730.1 - 0.0039 17.6 9.5 0.41 11.1 0.0 6.0 6 1 1 7 7 7 1 HEAT-like repeat T_hemolysin PF12261.3 EFE40730.1 - 0.11 11.9 0.1 0.34 10.4 0.0 1.8 2 0 0 2 2 2 0 Thermostable hemolysin DUF1772 PF08592.6 EFE40731.1 - 2.7 7.6 9.4 3.5 7.3 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Methyltransf_2 PF00891.13 EFE40732.1 - 7.2e-07 28.6 0.0 7.9e-07 28.5 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase DUF1077 PF06417.7 EFE40733.1 - 1.9e-45 153.2 4.3 2.2e-45 153.0 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) TMEM171 PF15471.1 EFE40733.1 - 2.3 6.9 10.5 4.4 6.0 7.3 1.5 1 0 0 1 1 1 0 Transmembrane protein family 171 Aminotran_5 PF00266.14 EFE40734.1 - 4.9e-10 38.6 0.0 1.3e-09 37.3 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFE40734.1 - 0.00029 20.0 0.0 0.00047 19.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Hemerythrin PF01814.18 EFE40736.1 - 3.3e-13 49.9 0.5 5.2e-13 49.3 0.3 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain NTF2 PF02136.15 EFE40737.1 - 4.9e-28 97.8 0.1 3.6e-19 69.2 0.0 2.0 1 1 1 2 2 2 2 Nuclear transport factor 2 (NTF2) domain Surp PF01805.15 EFE40738.1 - 2.3e-16 59.1 0.0 4.4e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Surp module DUF1765 PF08578.5 EFE40739.1 - 1.9e-41 141.0 0.6 3.9e-41 140.0 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) ATP_sub_h PF10775.4 EFE40740.1 - 4.7e-22 77.4 4.5 6.5e-22 77.0 2.7 1.6 1 1 0 1 1 1 1 ATP synthase complex subunit h TFIIB PF00382.14 EFE40741.1 - 1.1e-37 127.6 0.0 7.7e-20 70.4 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EFE40741.1 - 2.9e-10 39.2 1.0 2.9e-10 39.2 0.7 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding RB_B PF01857.15 EFE40741.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain DZR PF12773.2 EFE40741.1 - 0.12 12.1 1.2 0.55 10.1 0.1 2.3 2 0 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.1 EFE40741.1 - 1.3 8.3 4.5 0.34 10.1 0.5 2.0 2 0 0 2 2 2 0 zinc-ribbon domain TFR_dimer PF04253.10 EFE40742.1 - 6.2e-22 77.4 0.1 1.4e-20 73.1 0.1 2.3 1 1 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 EFE40742.1 - 7.7e-12 45.3 0.0 1.4e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EFE40742.1 - 1.5e-08 34.2 0.1 2.7e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 PA domain HMG_CoA_synt_C PF08540.5 EFE40743.1 - 1.7e-101 339.4 0.1 2.1e-101 339.1 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 EFE40743.1 - 2.3e-94 313.7 0.1 3.8e-94 313.0 0.1 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal DUF3541 PF12060.3 EFE40743.1 - 0.14 11.4 0.3 0.36 10.1 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) GFO_IDH_MocA PF01408.17 EFE40745.1 - 2.2e-11 44.2 0.0 4.3e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EFE40745.1 - 0.0026 17.5 0.0 0.008 15.9 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain PGM_PMM_III PF02880.11 EFE40746.1 - 7.8e-25 87.1 0.0 1.4e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.11 EFE40746.1 - 2.3e-20 72.4 0.4 4.1e-18 65.1 0.3 2.2 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EFE40746.1 - 1.8e-16 60.3 0.1 5.2e-16 58.8 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EFE40746.1 - 3.1e-11 43.1 0.0 7.4e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Transformer PF06495.6 EFE40747.1 - 0.2 11.5 3.6 0.27 11.1 2.5 1.3 1 1 0 1 1 1 0 Fruit fly transformer protein BLVR PF06375.6 EFE40747.1 - 4.6 7.0 10.2 5.1 6.9 7.1 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) TSGP1 PF07771.6 EFE40747.1 - 8 6.3 7.0 10 5.9 4.9 1.2 1 0 0 1 1 1 0 Tick salivary peptide group 1 RNase_T PF00929.19 EFE40748.1 - 2.7e-19 70.0 0.0 3.1e-19 69.8 0.0 1.0 1 0 0 1 1 1 1 Exonuclease PDR_CDR PF06422.7 EFE40749.1 - 0.19 11.4 0.9 0.44 10.2 0.6 1.6 1 0 0 1 1 1 0 CDR ABC transporter Sugar_tr PF00083.19 EFE40751.1 - 4.5e-80 269.4 25.8 5.8e-67 226.2 12.0 2.8 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE40751.1 - 1.5e-12 46.9 29.3 1.2e-08 34.1 10.6 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily UAA PF08449.6 EFE40751.1 - 0.0026 16.7 0.5 0.0054 15.6 0.3 1.5 1 0 0 1 1 1 1 UAA transporter family Peptidase_S32 PF05579.8 EFE40752.1 - 0.11 11.4 0.1 0.55 9.1 0.0 1.8 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Herpes_US9 PF06072.6 EFE40753.1 - 0.068 13.0 1.9 0.15 11.8 1.3 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF3331 PF11811.3 EFE40753.1 - 0.11 12.1 0.4 0.13 11.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3331) Piwi PF02171.12 EFE40754.1 - 8.3e-61 205.5 0.0 1.5e-60 204.7 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 EFE40754.1 - 4.7e-15 55.0 0.8 9.6e-15 54.0 0.5 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 EFE40754.1 - 1.6e-05 24.1 0.1 4.4e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) NAP PF00956.13 EFE40754.1 - 0.0053 15.9 0.4 0.011 14.9 0.3 1.4 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Y_phosphatase PF00102.22 EFE40755.1 - 1.2e-40 139.3 0.0 2.3e-24 86.0 0.0 2.1 1 1 0 2 2 2 2 Protein-tyrosine phosphatase CENP-T PF15511.1 EFE40755.1 - 0.039 13.2 10.7 0.035 13.3 6.7 1.5 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T Nucleo_P87 PF07267.6 EFE40755.1 - 1.4 7.4 8.3 1.7 7.1 5.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Pox_Ag35 PF03286.9 EFE40755.1 - 1.5 8.3 12.1 3.6 7.0 8.1 1.9 3 0 0 3 3 3 0 Pox virus Ag35 surface protein VanZ PF04892.7 EFE40756.1 - 1.4e-12 47.7 0.1 1.8e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 VanZ like family DuoxA PF10204.4 EFE40756.1 - 0.059 12.4 0.1 0.092 11.7 0.1 1.2 1 0 0 1 1 1 0 Dual oxidase maturation factor DUF4131 PF13567.1 EFE40756.1 - 4.5 6.6 8.4 12 5.3 2.9 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Bromodomain PF00439.20 EFE40757.1 - 9.3e-19 67.1 2.6 1e-18 67.0 0.1 2.3 3 0 0 3 3 3 1 Bromodomain Bromo_TP PF07524.8 EFE40757.1 - 1.7e-08 34.0 0.0 4.6e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated NADH_Oxid_Nqo15 PF11497.3 EFE40757.1 - 0.073 12.7 0.1 0.2 11.4 0.0 1.6 2 0 0 2 2 2 0 NADH-quinone oxidoreductase chain 15 TPP_enzyme_M PF00205.17 EFE40758.1 - 7.5e-24 84.0 0.0 2.4e-23 82.4 0.0 1.8 1 1 1 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 EFE40758.1 - 2.9e-21 75.7 0.0 2.5e-19 69.3 0.0 2.2 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EFE40758.1 - 7.6e-12 45.0 0.0 1.8e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain THUMP PF02926.12 EFE40759.1 - 1.5e-08 34.6 0.0 2.6e-08 33.8 0.0 1.5 1 1 0 1 1 1 1 THUMP domain APH PF01636.18 EFE40760.1 - 0.0001 22.0 0.0 0.00016 21.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Lgl_C PF08596.5 EFE40761.1 - 9e-122 406.3 0.0 2e-121 405.1 0.0 1.6 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.27 EFE40761.1 - 0.0066 16.2 1.2 6.9 6.7 0.0 4.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Fe-S_biosyn PF01521.15 EFE40763.1 - 9e-10 38.4 0.0 3.5e-08 33.3 0.0 2.0 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Paf67 PF10255.4 EFE40764.1 - 3.1e-156 520.3 0.0 3.6e-156 520.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 EFE40764.1 - 0.019 14.8 0.0 0.11 12.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RRM_6 PF14259.1 EFE40765.1 - 0.00036 20.4 0.1 0.12 12.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Cytochrom_B561 PF03188.11 EFE40766.1 - 5.3e-08 32.7 13.3 1.2e-07 31.6 9.2 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DOMON PF03351.12 EFE40766.1 - 0.019 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 DOMON domain PDH PF02153.12 EFE40767.1 - 3e-09 36.1 0.0 4.4e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase JSRP PF15312.1 EFE40768.1 - 0.062 13.2 0.2 0.066 13.1 0.2 1.0 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein DUF3682 PF12446.3 EFE40768.1 - 0.83 9.9 7.7 0.88 9.8 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Nucleoplasmin PF03066.10 EFE40768.1 - 1.1 8.7 5.9 0.99 8.9 4.1 1.0 1 0 0 1 1 1 0 Nucleoplasmin Brevenin PF03032.10 EFE40768.1 - 3.3 7.6 7.7 3.7 7.4 5.3 1.2 1 0 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family Ribosomal_60s PF00428.14 EFE40768.1 - 5.5 7.4 7.0 5.2 7.5 4.9 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ribosomal_S11 PF00411.14 EFE40769.1 - 9.7e-25 86.8 1.6 6.1e-24 84.3 1.1 1.8 1 1 0 1 1 1 1 Ribosomal protein S11 AAR2 PF05282.6 EFE40770.1 - 2.9e-85 286.3 0.0 3.6e-85 286.0 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S9 PF00380.14 EFE40771.1 - 4.6e-38 130.1 0.3 5.2e-38 130.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Nckap1 PF09735.4 EFE40771.1 - 0.055 10.9 0.0 0.061 10.8 0.0 1.0 1 0 0 1 1 1 0 Membrane-associated apoptosis protein Ribosomal_L13 PF00572.13 EFE40772.1 - 3.9e-33 114.2 0.1 4.8e-33 113.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Uricase PF01014.13 EFE40773.1 - 1e-76 255.6 0.4 1.8e-43 147.9 0.6 2.0 2 0 0 2 2 2 2 Uricase Mob_Pre PF01076.14 EFE40773.1 - 0.14 11.7 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Plasmid recombination enzyme RICTOR_N PF14664.1 EFE40774.1 - 2.4e-136 454.1 0.6 5.1e-136 453.1 0.4 1.6 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.1 EFE40774.1 - 7.6e-91 303.1 0.9 7.3e-88 293.3 0.2 4.3 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.1 EFE40774.1 - 1.8e-43 147.0 0.0 7.4e-43 145.1 0.0 2.1 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.1 EFE40774.1 - 1.2e-25 89.2 5.0 2.3e-24 85.0 0.1 4.7 6 0 0 6 6 6 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.11 EFE40774.1 - 1.8e-09 37.2 12.8 5.2e-09 35.7 8.8 1.8 1 0 0 1 1 1 1 Hr1 repeat Arm PF00514.18 EFE40774.1 - 1.1 9.2 4.3 67 3.5 0.1 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat LON PF02190.11 EFE40775.1 - 4e-19 69.1 0.0 5.6e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain zf-C3HC4_2 PF13923.1 EFE40775.1 - 7.1e-10 38.7 25.5 2.8e-08 33.6 6.5 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFE40775.1 - 4.9e-09 35.9 23.5 4.4e-05 23.2 6.3 3.1 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 EFE40775.1 - 6.3e-09 35.5 23.8 1.3e-08 34.5 6.4 2.7 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.1 EFE40775.1 - 3.3e-08 33.1 23.4 4.8e-07 29.3 5.1 2.7 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4 PF00097.20 EFE40775.1 - 6e-08 32.2 21.0 7.8e-07 28.6 5.6 2.9 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE40775.1 - 1.4e-07 31.0 21.0 3.1e-07 29.9 5.1 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFE40775.1 - 1e-06 28.3 21.2 3.3e-05 23.5 1.1 3.6 3 0 0 3 3 3 2 RING-type zinc-finger zf-P11 PF03854.9 EFE40775.1 - 0.00084 18.7 6.9 0.00084 18.7 4.8 2.9 4 0 0 4 4 3 1 P-11 zinc finger zf-rbx1 PF12678.2 EFE40775.1 - 0.003 17.6 2.1 0.003 17.6 1.4 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger U-box PF04564.10 EFE40775.1 - 0.0058 16.5 0.8 0.026 14.4 0.1 2.3 2 0 0 2 2 2 1 U-box domain zf-RING_4 PF14570.1 EFE40775.1 - 1.4 8.5 19.4 0.024 14.1 4.4 3.3 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Paf1 PF03985.8 EFE40776.1 - 1.5e-39 136.0 4.0 8.2e-24 84.1 0.0 3.0 3 0 0 3 3 3 3 Paf1 Actin PF00022.14 EFE40777.1 - 2.9e-26 91.8 0.0 1.4e-14 53.3 0.0 2.8 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.8 EFE40777.1 - 1.8e-05 23.5 0.0 0.015 13.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Arf PF00025.16 EFE40778.1 - 5.1e-73 244.0 0.0 6.2e-73 243.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFE40778.1 - 1.5e-11 43.8 0.0 1.9e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 EFE40778.1 - 3.1e-10 39.2 0.8 1.5e-06 27.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 EFE40778.1 - 8.3e-10 38.2 0.0 1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 EFE40778.1 - 1.2e-08 34.4 0.0 1.5e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EFE40778.1 - 3.3e-08 34.0 0.0 4.5e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFE40778.1 - 4.3e-06 26.6 0.0 6.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFE40778.1 - 9.4e-05 21.9 0.0 0.014 14.8 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 EFE40778.1 - 0.0092 15.2 0.5 0.043 13.0 0.3 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF3986 PF13143.1 EFE40778.1 - 0.1 13.0 0.2 0.3 11.5 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3986) Glyco_hydro_72 PF03198.9 EFE40779.1 - 6.2e-121 403.2 3.7 7.5e-121 402.9 2.6 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 EFE40779.1 - 1.5e-06 27.6 0.4 1.6e-05 24.2 0.3 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SH3_9 PF14604.1 EFE40780.1 - 1.4e-19 69.4 0.7 1.9e-10 40.1 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 EFE40780.1 - 2.3e-17 62.1 0.4 1.7e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 SH3 domain FCH PF00611.18 EFE40780.1 - 5.1e-15 55.4 0.0 5.1e-15 55.4 0.0 2.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain C1_1 PF00130.17 EFE40780.1 - 5.7e-15 54.7 5.2 8.8e-15 54.1 3.6 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.12 EFE40780.1 - 8.5e-07 28.3 0.1 0.00028 20.3 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 EFE40780.1 - 0.0033 17.5 1.0 0.022 14.9 0.1 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain DUF342 PF03961.8 EFE40780.1 - 1.1 7.5 6.2 0.32 9.3 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF342) DEAD PF00270.24 EFE40781.1 - 6.5e-34 116.8 0.7 1.6e-32 112.3 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE40781.1 - 5.3e-22 77.4 0.2 1.4e-21 76.1 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain tRNA-synt_1b PF00579.20 EFE40781.1 - 0.082 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) DAO PF01266.19 EFE40782.1 - 1e-43 149.6 0.0 1.5e-43 149.1 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.1 EFE40782.1 - 0.00012 21.1 0.0 0.065 12.1 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 EFE40782.1 - 0.0013 18.8 0.0 0.36 10.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFE40782.1 - 0.011 15.7 0.3 0.025 14.6 0.0 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFE40782.1 - 0.013 15.3 0.0 0.14 11.8 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.9 EFE40782.1 - 0.039 12.4 0.1 5.3 5.4 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein NAD_kinase PF01513.16 EFE40783.1 - 1.9e-51 174.5 0.0 1.8e-35 122.1 0.0 2.2 1 1 1 2 2 2 2 ATP-NAD kinase Pro-kuma_activ PF09286.6 EFE40784.1 - 5.9e-35 120.4 0.0 1e-34 119.5 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFE40784.1 - 1.4e-10 40.8 0.3 2.1e-10 40.2 0.2 1.4 1 1 0 1 1 1 1 Subtilase family DUF853 PF05872.7 EFE40785.1 - 0.12 10.6 0.1 0.14 10.5 0.0 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF3735 PF12537.3 EFE40785.1 - 0.2 11.6 0.9 0.28 11.2 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3735) Glyco_hydro_79n PF03662.9 EFE40786.1 - 0.11 11.0 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain RNase_PH_C PF03725.10 EFE40786.1 - 0.13 12.1 0.0 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 E1-E2_ATPase PF00122.15 EFE40787.1 - 1e-64 217.7 6.9 1.8e-64 216.9 4.8 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE40787.1 - 1.3e-31 109.5 3.5 1.3e-31 109.5 2.5 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE40787.1 - 2.4e-27 96.7 0.0 1.4e-25 91.0 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE40787.1 - 3.5e-13 49.3 0.0 6.9e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE40787.1 - 1.5e-12 48.1 0.0 5.1e-12 46.3 0.0 2.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE40787.1 - 1.7e-05 24.5 1.5 1.7e-05 24.5 1.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.5 EFE40787.1 - 0.015 14.9 0.9 0.04 13.5 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) DUF2014 PF09427.5 EFE40788.1 - 1.7e-102 342.0 0.3 2.5e-102 341.4 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.21 EFE40788.1 - 1.7e-18 66.0 1.6 3.8e-18 64.9 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DHDPS PF00701.17 EFE40789.1 - 5.4e-45 153.2 0.0 6.2e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Myc_N PF01056.13 EFE40790.1 - 0.039 13.1 6.0 0.073 12.2 4.2 1.3 1 0 0 1 1 1 0 Myc amino-terminal region Daxx PF03344.10 EFE40790.1 - 0.12 10.8 11.2 0.2 10.0 7.8 1.3 1 0 0 1 1 1 0 Daxx Family Ribosomal_60s PF00428.14 EFE40790.1 - 0.35 11.3 9.2 1.2 9.6 6.5 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF2890 PF11081.3 EFE40790.1 - 0.65 10.0 11.1 1.4 8.9 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) DUF4564 PF15169.1 EFE40790.1 - 0.66 9.6 4.4 1.2 8.8 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4564) TRAP_alpha PF03896.11 EFE40790.1 - 4.5 6.1 5.8 7.2 5.5 4.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MFS_1 PF07690.11 EFE40791.1 - 3.6e-35 121.3 27.0 5.7e-35 120.6 18.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Miff PF05644.6 EFE40791.1 - 0.1 12.2 0.4 0.23 11.0 0.3 1.5 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Chorismate_bind PF00425.13 EFE40792.1 - 8.1e-70 235.0 0.0 2.2e-46 158.2 0.0 2.3 1 1 1 2 2 2 2 chorismate binding enzyme GATase PF00117.23 EFE40792.1 - 1.9e-33 115.5 0.0 3e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 EFE40792.1 - 4.1e-09 36.5 0.0 8.7e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 EFE40792.1 - 2.4e-08 33.7 0.0 4.8e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 Ank_2 PF12796.2 EFE40793.1 - 1.3e-30 105.6 0.1 1.2e-17 64.0 0.1 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE40793.1 - 4.8e-25 87.4 2.0 2.8e-09 37.2 0.1 4.7 1 1 5 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE40793.1 - 2.3e-23 81.6 1.2 1.8e-07 31.1 0.0 5.3 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 EFE40793.1 - 4.1e-22 76.8 2.7 0.00057 19.5 0.1 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.1 EFE40793.1 - 1.6e-20 71.0 0.1 0.0014 18.6 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat DUF3447 PF11929.3 EFE40793.1 - 0.00051 19.7 0.0 0.1 12.3 0.0 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF3447) F-box-like PF12937.2 EFE40793.1 - 0.052 13.2 0.2 0.097 12.4 0.2 1.4 1 0 0 1 1 1 0 F-box-like HAD PF12710.2 EFE40795.1 - 0.032 14.4 0.0 0.042 14.0 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Med3 PF11593.3 EFE40795.1 - 2.7 7.1 10.9 3.3 6.8 7.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pneumo_att_G PF05539.6 EFE40795.1 - 3.8 6.7 8.8 4.6 6.5 6.1 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Mito_carr PF00153.22 EFE40796.1 - 7.8e-31 105.6 0.0 1.7e-16 59.6 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Anp1 PF03452.9 EFE40797.1 - 1.6e-102 342.3 0.0 2.6e-102 341.6 0.0 1.3 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.21 EFE40797.1 - 0.019 14.6 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Zip PF02535.17 EFE40798.1 - 5.3e-59 199.7 10.7 3.6e-58 197.0 7.4 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter Nop16 PF09420.5 EFE40799.1 - 3.6e-56 189.7 11.5 4.4e-56 189.5 7.9 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Pex24p PF06398.6 EFE40801.1 - 7.5e-72 242.1 0.0 1.7e-71 240.9 0.0 1.5 1 1 1 2 2 2 1 Integral peroxisomal membrane peroxin ATP-synt_8 PF00895.15 EFE40801.1 - 3 8.1 7.8 1 9.6 1.1 3.0 2 1 1 3 3 3 0 ATP synthase protein 8 Pkinase PF00069.20 EFE40802.1 - 3.2e-56 190.3 0.0 4.5e-56 189.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40802.1 - 2.2e-19 69.5 0.0 3.6e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 EFE40802.1 - 0.21 10.9 0.1 0.47 9.7 0.0 1.6 1 0 0 1 1 1 0 RIO1 family COPIIcoated_ERV PF07970.7 EFE40803.1 - 2.6e-29 102.4 0.4 2e-27 96.2 0.3 2.9 1 1 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 EFE40803.1 - 9.2e-23 80.0 0.0 1.7e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Abhydrolase_6 PF12697.2 EFE40804.1 - 1.5e-25 90.4 0.0 1.8e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE40804.1 - 1.7e-07 31.0 0.0 2.4e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase PF07224.6 EFE40804.1 - 0.0031 16.3 0.0 0.038 12.7 0.0 2.0 1 1 1 2 2 2 1 Chlorophyllase Chlorophyllase2 PF12740.2 EFE40804.1 - 0.011 14.6 0.0 0.024 13.5 0.0 1.6 1 1 1 2 2 2 0 Chlorophyllase enzyme Hydrolase_4 PF12146.3 EFE40804.1 - 0.026 14.3 0.0 0.051 13.4 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase PGAP1 PF07819.8 EFE40804.1 - 0.044 13.3 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.8 EFE40804.1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold N2227 PF07942.7 EFE40806.1 - 7e-62 208.8 0.0 9.3e-62 208.4 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 EFE40806.1 - 0.0031 17.2 0.0 0.0076 15.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CCDC155 PF14662.1 EFE40807.1 - 0.00048 19.7 10.4 0.00048 19.7 7.2 3.4 2 1 1 3 3 3 2 Coiled-coil region of CCDC155 Tropomyosin_1 PF12718.2 EFE40807.1 - 0.00059 19.7 27.3 0.00059 19.7 18.9 5.3 5 1 1 6 6 6 2 Tropomyosin like IncA PF04156.9 EFE40807.1 - 0.0021 17.7 20.0 0.0021 17.7 13.9 4.3 2 1 2 4 4 4 2 IncA protein Filament PF00038.16 EFE40807.1 - 0.024 14.1 48.6 0.084 12.3 22.6 4.2 1 1 0 2 2 2 0 Intermediate filament protein Reo_sigmaC PF04582.7 EFE40807.1 - 0.066 12.3 18.8 0.021 13.9 5.8 2.3 1 1 1 2 2 2 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 EFE40807.1 - 0.6 10.3 15.8 1.5 9.0 0.3 4.4 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Herpes_LMP1 PF05297.6 EFE40807.1 - 3.5 6.4 4.5 6 5.6 3.1 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Maf1 PF09174.5 EFE40808.1 - 1.1e-63 214.3 0.0 1.4e-63 213.9 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator Clat_adaptor_s PF01217.15 EFE40809.1 - 1.9e-33 115.1 0.8 2.8e-33 114.6 0.6 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain zf-C2H2_2 PF12756.2 EFE40809.1 - 6.2 6.9 14.1 3.3 7.8 1.4 2.9 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Aldo_ket_red PF00248.16 EFE40810.1 - 3.8e-15 55.4 0.0 5.4e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.20 EFE40811.1 - 2.2e-07 30.3 0.0 4.5e-07 29.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 EFE40811.1 - 7e-07 28.5 0.0 0.002 17.2 0.0 3.0 2 1 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE40811.1 - 8.7e-07 28.9 0.0 0.0026 17.5 0.0 2.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 EFE40811.1 - 0.012 14.7 0.0 0.025 13.6 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase RIO1 PF01163.17 EFE40811.1 - 0.035 13.4 0.0 1.2 8.4 0.0 2.7 3 0 0 3 3 3 0 RIO1 family Metallophos PF00149.23 EFE40813.1 - 5.2e-06 25.9 0.4 1.1e-05 24.9 0.3 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase STE2 PF02116.10 EFE40814.1 - 5.9e-83 278.1 25.2 7.2e-83 277.9 17.4 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR WD40 PF00400.27 EFE40815.1 - 6.8e-22 76.4 2.6 0.00037 20.2 0.0 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat Vps23_core PF09454.5 EFE40816.1 - 9.5e-21 73.1 0.0 1e-19 69.8 0.0 2.3 2 0 0 2 2 2 1 Vps23 core domain CENP-Q PF13094.1 EFE40816.1 - 0.0073 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit ADIP PF11559.3 EFE40816.1 - 0.017 15.0 2.4 0.031 14.1 1.7 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.7 EFE40816.1 - 0.059 12.5 3.9 0.087 11.9 2.7 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Halo_GVPC PF05465.8 EFE40816.1 - 0.19 11.7 0.1 0.39 10.6 0.1 1.6 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat IDO PF01231.13 EFE40817.1 - 6.9e-119 397.0 0.0 7.9e-119 396.8 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase zf-ISL3 PF14690.1 EFE40818.1 - 0.044 13.8 3.4 0.93 9.5 0.3 2.5 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 M20_dimer PF07687.9 EFE40818.1 - 0.16 11.7 3.7 2.2 8.0 0.2 2.8 3 0 0 3 3 3 0 Peptidase dimerisation domain HAMP PF00672.20 EFE40819.1 - 8.2e-44 147.6 16.9 1.4e-09 37.9 0.4 6.9 6 0 0 6 6 6 6 HAMP domain HATPase_c PF02518.21 EFE40819.1 - 9.7e-31 105.7 0.2 4.7e-30 103.5 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EFE40819.1 - 2.3e-26 92.0 2.0 3.3e-24 85.0 0.2 3.1 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.20 EFE40819.1 - 4.9e-17 61.6 5.8 2.9e-16 59.2 0.0 4.5 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain NOD PF06816.8 EFE40819.1 - 0.029 13.4 0.1 0.86 8.7 0.0 2.7 2 0 0 2 2 2 0 NOTCH protein Vps52 PF04129.7 EFE40819.1 - 0.031 12.8 3.8 3.2 6.1 0.1 3.8 4 0 0 4 4 4 0 Vps52 / Sac2 family Pox_A_type_inc PF04508.7 EFE40819.1 - 0.056 13.2 0.9 0.79 9.6 0.1 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Gp-FAR-1 PF05823.7 EFE40819.1 - 0.092 12.6 4.1 4 7.3 0.0 4.0 3 2 1 4 4 4 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) NAAA-beta PF15508.1 EFE40819.1 - 0.095 13.0 4.8 9.8 6.6 0.1 5.8 5 3 2 7 7 7 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase AAA_13 PF13166.1 EFE40819.1 - 0.23 9.8 25.4 0.64 8.4 0.8 4.1 1 1 2 5 5 4 0 AAA domain DUF948 PF06103.6 EFE40819.1 - 1.2 9.0 33.3 7.5 6.4 0.6 7.9 4 3 4 8 8 8 0 Bacterial protein of unknown function (DUF948) Ribosomal_60s PF00428.14 EFE40820.1 - 7.1 7.0 6.0 15 6.0 4.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein MFS_1 PF07690.11 EFE40821.1 - 1.4e-28 99.6 40.6 1.4e-28 99.6 28.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40821.1 - 6.2e-10 38.2 38.1 4.3e-07 28.8 10.0 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE40822.1 - 4e-27 94.8 28.5 8.1e-19 67.5 15.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40822.1 - 3e-24 85.4 12.7 6.4e-24 84.3 8.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter Pkinase PF00069.20 EFE40823.1 - 1.3e-69 234.2 0.0 2e-69 233.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40823.1 - 3.4e-34 118.1 0.0 5.4e-33 114.1 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE40823.1 - 0.00072 18.6 0.3 0.72 8.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.17 EFE40823.1 - 0.032 13.5 0.2 0.068 12.5 0.1 1.6 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.6 EFE40823.1 - 0.071 11.9 0.1 0.19 10.4 0.0 1.7 1 1 1 2 2 2 0 Poxvirus serine/threonine protein kinase Fungal_trans PF04082.13 EFE40826.1 - 2e-11 43.2 0.4 3.5e-11 42.4 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1395 PF07160.7 EFE40826.1 - 0.015 14.7 0.6 0.032 13.7 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1395) BOP1NT PF08145.7 EFE40826.1 - 0.018 14.7 1.3 0.031 14.0 0.9 1.2 1 0 0 1 1 1 0 BOP1NT (NUC169) domain Miff PF05644.6 EFE40826.1 - 0.26 10.9 4.9 0.43 10.1 3.4 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff EspF PF04806.7 EFE40827.1 - 5.3 7.3 20.4 0.072 13.2 1.7 3.8 3 0 0 3 3 3 0 EspF protein repeat PI-PLC-X PF00388.14 EFE40828.1 - 6.9e-41 139.0 0.0 1.4e-40 138.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EFE40828.1 - 7.7e-33 112.9 0.0 6.4e-32 110.0 0.0 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain PI-PLC-X PF00388.14 EFE40829.1 - 7.9e-12 44.7 0.3 1.3e-11 44.0 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain GST_C PF00043.20 EFE40831.1 - 3e-08 33.5 0.0 4.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFE40831.1 - 7.9e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 EFE40831.1 - 1.1e-05 25.5 0.0 3.4e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE40831.1 - 0.00097 18.9 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EFE40831.1 - 0.0047 16.8 0.0 0.0093 15.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain ERO1 PF04137.10 EFE40832.1 - 1e-132 442.5 0.0 1.4e-132 442.0 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) TPP_enzyme_N PF02776.13 EFE40833.1 - 2.5e-44 150.7 0.2 5e-44 149.8 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 EFE40833.1 - 5.6e-33 113.5 0.0 1.1e-32 112.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 EFE40833.1 - 3.2e-18 65.7 0.0 7.3e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.11 EFE40833.1 - 0.031 13.8 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit TPR_1 PF00515.23 EFE40834.1 - 1.1e-26 91.3 1.9 2.4e-09 36.3 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 EFE40834.1 - 1.5e-26 91.8 5.0 3.3e-11 42.6 0.1 4.5 2 2 2 4 4 4 4 TPR repeat TPR_2 PF07719.12 EFE40834.1 - 1.1e-24 84.3 2.8 1.3e-07 30.9 0.0 6.0 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_14 PF13428.1 EFE40834.1 - 1e-19 69.1 2.9 3.5e-05 24.0 0.0 5.7 4 1 2 6 6 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 EFE40834.1 - 2e-17 61.8 1.9 0.00081 19.4 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 EFE40834.1 - 5.3e-17 61.9 5.7 1.1e-05 25.9 0.0 4.8 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_19 PF14559.1 EFE40834.1 - 1.4e-15 57.3 1.7 0.0004 20.6 0.0 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFE40834.1 - 2.3e-14 53.0 2.4 2.5e-08 33.7 0.1 3.9 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFE40834.1 - 2.6e-14 51.8 0.1 3.3e-05 23.3 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE40834.1 - 2.1e-11 42.6 2.1 0.00061 19.3 0.0 6.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.1 EFE40834.1 - 1.9e-09 37.5 4.9 0.0018 18.3 0.0 4.8 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFE40834.1 - 2.3e-09 36.9 1.1 0.0054 16.5 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 EFE40834.1 - 4.2e-07 30.0 2.1 1.6 9.3 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat Apc3 PF12895.2 EFE40834.1 - 6e-07 29.5 0.4 0.00025 21.1 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 EFE40834.1 - 0.0012 18.0 0.3 1 8.3 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 EFE40834.1 - 0.0018 18.1 0.5 0.45 10.5 0.1 3.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_3 PF07720.7 EFE40834.1 - 0.0018 18.0 0.0 3 7.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TOM20_plant PF06552.7 EFE40834.1 - 0.035 13.7 0.1 3.7 7.0 0.0 3.0 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 MIT PF04212.13 EFE40834.1 - 0.045 13.6 1.3 2.7 7.9 0.3 3.9 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF4192 PF13830.1 EFE40834.1 - 0.79 9.3 5.6 1.5 8.4 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4192) RRM_1 PF00076.17 EFE40835.1 - 4.2e-33 112.8 0.0 2.7e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40835.1 - 6.9e-24 83.6 0.0 1.2e-14 54.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE40835.1 - 8.2e-14 51.2 0.0 9.6e-09 34.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFE40835.1 - 0.012 15.4 0.6 0.08 12.8 0.0 2.4 3 1 0 3 3 3 0 RNA binding motif Fungal_trans PF04082.13 EFE40836.1 - 2.3e-10 39.7 0.1 5.3e-10 38.5 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain HSBP1 PF06825.7 EFE40836.1 - 0.019 14.5 0.1 0.039 13.5 0.1 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 SnoaL PF07366.7 EFE40837.1 - 0.0088 15.6 0.4 0.26 10.8 0.0 2.9 2 1 0 2 2 2 1 SnoaL-like polyketide cyclase SHS2_Rpb7-N PF03876.12 EFE40838.1 - 3.7e-14 52.5 0.1 4.5e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF962 PF06127.6 EFE40839.1 - 1.9e-14 53.3 4.9 6.1e-14 51.6 3.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) ATP-synt_ab PF00006.20 EFE40841.1 - 1.1e-71 240.7 0.0 1.4e-71 240.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EFE40841.1 - 2.2e-25 89.3 0.5 6.4e-25 87.8 0.1 2.0 2 1 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EFE40841.1 - 1.9e-12 47.2 1.1 4.5e-12 45.9 0.7 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_25 PF13481.1 EFE40841.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain THF_DHG_CYH PF00763.18 EFE40842.1 - 3.6e-18 65.7 0.0 5.8e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 EFE40842.1 - 1.1e-13 50.5 0.0 2.8e-09 36.2 0.0 2.8 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SPC25 PF06703.6 EFE40843.1 - 2.4e-11 43.4 0.2 2.8e-11 43.2 0.1 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF106 PF01956.11 EFE40844.1 - 2.8e-46 157.1 0.1 3.4e-46 156.8 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF106 Fasciclin PF02469.17 EFE40845.1 - 0.0039 17.1 0.0 0.0076 16.2 0.0 1.5 1 1 0 1 1 1 1 Fasciclin domain MMS19_N PF14500.1 EFE40846.1 - 2.9e-18 66.0 0.0 3.9e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.1 EFE40846.1 - 0.074 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 HEAT repeats MMS19_C PF12460.3 EFE40847.1 - 6e-122 407.3 17.0 9e-122 406.7 8.2 3.2 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.1 EFE40847.1 - 2.6e-41 141.6 0.3 2.9e-40 138.2 0.0 2.8 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.1 EFE40847.1 - 1.3e-05 25.3 5.3 0.9 9.8 0.1 4.8 4 0 0 4 4 4 3 HEAT repeats MRP_L53 PF10780.4 EFE40847.1 - 0.31 11.0 2.0 0.56 10.2 0.2 2.5 2 0 0 2 2 2 0 39S ribosomal protein L53/MRP-L53 HEAT_EZ PF13513.1 EFE40847.1 - 0.38 11.3 10.8 81 3.9 0.0 6.1 5 1 0 5 5 5 0 HEAT-like repeat HEAT PF02985.17 EFE40847.1 - 2.2 8.6 11.3 23 5.3 0.2 5.1 5 0 0 5 5 5 0 HEAT repeat CLASP_N PF12348.3 EFE40847.1 - 3.1 7.1 7.8 0.89 8.8 1.1 3.2 4 1 0 4 4 4 0 CLASP N terminal ATG16 PF08614.6 EFE40849.1 - 0.48 10.2 34.9 1.1 9.0 12.9 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Filament PF00038.16 EFE40849.1 - 0.53 9.7 35.0 0.73 9.2 11.5 2.1 1 1 1 2 2 2 0 Intermediate filament protein TSC22 PF01166.13 EFE40849.1 - 6.2 6.8 9.8 2.2 8.2 1.0 3.5 1 1 2 3 3 3 0 TSC-22/dip/bun family Peroxin-13_N PF04088.8 EFE40850.1 - 4.3e-60 202.2 0.1 7.7e-60 201.4 0.1 1.4 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.12 EFE40850.1 - 2.1e-09 36.6 0.0 3.7e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFE40850.1 - 9.6e-08 31.2 0.0 1.7e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE40850.1 - 1.1e-06 28.1 0.1 1.8e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF3563 PF12086.3 EFE40850.1 - 0.12 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3563) Aminotran_5 PF00266.14 EFE40851.1 - 8e-30 103.8 0.0 1e-29 103.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V APG6 PF04111.7 EFE40852.1 - 1.5e-128 428.2 0.3 1.9e-128 427.9 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 DUF972 PF06156.8 EFE40852.1 - 0.021 15.1 1.4 0.055 13.8 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF972) OspD PF03207.8 EFE40852.1 - 0.052 12.7 1.9 0.093 11.8 1.3 1.3 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) Scm3 PF10384.4 EFE40853.1 - 3.4e-23 80.8 0.1 5.6e-23 80.1 0.1 1.3 1 0 0 1 1 1 1 Centromere protein Scm3 Myb_DNA-bind_6 PF13921.1 EFE40853.1 - 5.1e-06 26.5 2.3 0.039 14.0 0.8 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain PALP PF00291.20 EFE40854.1 - 1.4e-33 116.4 0.8 5.6e-32 111.1 0.6 2.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.12 EFE40855.1 - 4.8e-33 114.6 0.0 9.9e-33 113.5 0.0 1.5 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Pal1 PF08316.6 EFE40856.1 - 5.6e-07 30.0 0.1 1.1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Pal1 cell morphology protein Terpene_synth_C PF03936.11 EFE40857.1 - 2.7e-10 39.9 1.4 3.8e-10 39.4 0.9 1.3 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain HVSL PF09749.4 EFE40858.1 - 1.2e-60 204.5 0.0 4.6e-49 166.6 0.0 2.1 1 1 1 2 2 2 2 Uncharacterised conserved protein DUF3807 PF12720.2 EFE40859.1 - 4e-38 131.2 2.2 4.7e-38 131.0 1.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) PCEMA1 PF07418.6 EFE40860.1 - 0.023 14.0 0.2 0.025 13.9 0.1 1.0 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 CTP_transf_2 PF01467.21 EFE40863.1 - 1e-23 84.1 0.0 1.7e-23 83.4 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase EamA PF00892.15 EFE40865.1 - 1.3e-09 38.2 13.1 5e-07 29.7 6.5 3.6 2 1 1 3 3 3 2 EamA-like transporter family UPF0014 PF03649.8 EFE40865.1 - 0.13 11.4 1.7 0.23 10.6 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0014) DUF4131 PF13567.1 EFE40865.1 - 0.29 10.5 3.3 1.3 8.3 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) EmrE PF13536.1 EFE40865.1 - 0.5 10.5 14.1 0.64 10.2 5.6 3.0 2 1 1 3 3 3 0 Multidrug resistance efflux transporter DUF4149 PF13664.1 EFE40865.1 - 3.1 7.8 11.9 1.8 8.6 3.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) DUF1253 PF06862.7 EFE40866.1 - 1.9e-159 530.8 0.0 2.3e-159 530.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) DEAD PF00270.24 EFE40866.1 - 0.00067 19.1 0.0 0.034 13.6 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase JAB PF01398.16 EFE40867.1 - 5.5e-17 61.5 0.0 9.6e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 EFE40867.1 - 7.2e-15 55.0 0.1 1.3e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.8 EFE40867.1 - 0.11 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) TFIID-18kDa PF02269.11 EFE40868.1 - 2e-23 81.9 0.0 3.1e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.19 EFE40868.1 - 0.0023 18.0 0.1 0.0082 16.2 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.8 EFE40868.1 - 0.0087 16.3 0.1 0.017 15.3 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-S PF15630.1 EFE40868.1 - 0.032 14.4 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinetochore component CENP-S PPR_2 PF13041.1 EFE40870.1 - 1.4e-21 76.1 0.0 7e-10 38.7 0.0 4.5 3 1 1 4 4 4 3 PPR repeat family PPR PF01535.15 EFE40870.1 - 1.8e-14 52.6 0.1 0.00048 19.9 0.0 4.9 5 0 0 5 5 5 3 PPR repeat PPR_3 PF13812.1 EFE40870.1 - 9.8e-14 50.4 2.4 0.038 14.2 0.0 6.2 6 0 0 6 6 6 3 Pentatricopeptide repeat domain PPR_1 PF12854.2 EFE40870.1 - 1.7e-09 36.9 0.0 0.00021 20.7 0.0 3.9 4 0 0 4 4 4 2 PPR repeat cwf18 PF08315.7 EFE40871.1 - 8.6e-42 142.6 7.7 1.5e-41 141.8 5.3 1.4 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Transposase_24 PF03004.9 EFE40871.1 - 1.3 8.9 7.6 0.34 10.8 0.8 2.8 3 0 0 3 3 3 0 Plant transposase (Ptta/En/Spm family) SUZ PF12752.2 EFE40873.1 - 1.2e-19 70.5 3.9 1.2e-19 70.5 2.7 2.7 2 0 0 2 2 2 1 SUZ domain RRM_1 PF00076.17 EFE40874.1 - 9.7e-08 31.5 0.0 1.6e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE40874.1 - 4.7e-06 26.4 0.0 8.4e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) V_ATPase_I PF01496.14 EFE40874.1 - 0.002 16.1 0.2 0.0021 16.0 0.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4201 PF13870.1 EFE40874.1 - 0.013 14.9 0.5 0.016 14.6 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) EMP24_GP25L PF01105.19 EFE40874.1 - 0.015 14.9 0.7 0.02 14.6 0.5 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD CASP_C PF08172.7 EFE40874.1 - 0.017 14.1 0.1 0.022 13.8 0.1 1.1 1 0 0 1 1 1 0 CASP C terminal GAS PF13851.1 EFE40874.1 - 0.021 14.0 1.6 0.027 13.6 1.1 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Troponin PF00992.15 EFE40874.1 - 0.025 14.6 6.7 0.032 14.2 4.7 1.1 1 0 0 1 1 1 0 Troponin Flagellin_C PF00700.16 EFE40874.1 - 0.046 13.8 0.3 0.064 13.4 0.2 1.2 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region Med9 PF07544.8 EFE40874.1 - 0.05 13.3 0.9 0.079 12.7 0.6 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 IncA PF04156.9 EFE40874.1 - 0.06 12.9 1.5 0.066 12.7 1.0 1.1 1 0 0 1 1 1 0 IncA protein DUF342 PF03961.8 EFE40874.1 - 0.083 11.2 0.2 0.091 11.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.7 EFE40874.1 - 0.11 11.4 1.5 0.12 11.3 1.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 COG6 PF06419.6 EFE40874.1 - 0.13 10.3 0.9 0.16 10.0 0.6 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 YgaB PF14182.1 EFE40874.1 - 0.13 12.4 2.1 0.15 12.2 0.5 1.7 2 0 0 2 2 2 0 YgaB-like protein DUF904 PF06005.7 EFE40874.1 - 0.38 11.0 5.0 0.63 10.3 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DivIC PF04977.10 EFE40874.1 - 0.54 9.7 4.5 0.84 9.1 3.1 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4140 PF13600.1 EFE40874.1 - 0.57 10.6 3.1 0.94 9.9 1.9 1.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) HECT PF00632.20 EFE40876.1 - 1.3e-86 290.6 0.1 8.2e-86 288.0 0.1 2.0 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 EFE40876.1 - 2.6e-32 110.2 28.3 5.3e-11 42.1 4.6 4.6 4 0 0 4 4 4 3 WW domain Med9 PF07544.8 EFE40877.1 - 0.014 15.1 0.5 0.19 11.4 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Aminotran_5 PF00266.14 EFE40878.1 - 1.7e-27 96.1 0.0 2.3e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EFE40878.1 - 0.014 14.3 0.0 0.018 14.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II adh_short PF00106.20 EFE40878.1 - 0.07 13.0 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 short chain dehydrogenase NIF PF03031.13 EFE40879.1 - 5.1e-49 165.9 0.0 8.4e-49 165.2 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ATG16 PF08614.6 EFE40880.1 - 0.024 14.4 0.5 0.024 14.4 0.3 1.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fmp27_WPPW PF10359.4 EFE40880.1 - 0.16 10.3 0.6 0.19 10.1 0.4 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Striatin PF08232.7 EFE40880.1 - 0.3 11.3 3.6 0.55 10.5 2.5 1.5 1 1 0 1 1 1 0 Striatin family Rhomboid PF01694.17 EFE40881.1 - 1.6e-11 44.4 13.8 7.7e-11 42.2 8.0 2.6 2 1 0 2 2 2 1 Rhomboid family PhoD PF09423.5 EFE40882.1 - 7.7e-10 37.9 0.1 8.5e-07 27.8 0.1 2.2 2 1 0 2 2 2 2 PhoD-like phosphatase Gryzun PF07919.7 EFE40884.1 - 6.4e-118 394.4 1.3 7.2e-118 394.2 0.9 1.0 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Gryzun-like PF12742.2 EFE40884.1 - 0.0023 17.6 0.0 0.0073 16.0 0.0 1.8 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking Foie-gras_1 PF11817.3 EFE40885.1 - 2.8e-76 256.2 2.2 5.5e-68 229.1 1.6 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 DUF4228 PF14009.1 EFE40886.1 - 0.012 15.7 5.6 0.014 15.4 3.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF3446 PF11928.3 EFE40886.1 - 0.086 13.0 16.4 0.23 11.6 11.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3446) ORC6 PF05460.8 EFE40886.1 - 0.1 11.6 6.0 0.12 11.4 4.2 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF959 PF06121.9 EFE40886.1 - 0.11 12.1 3.4 0.14 11.7 2.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF959) GTSE1_N PF15259.1 EFE40886.1 - 0.15 11.9 3.6 0.19 11.6 2.5 1.1 1 0 0 1 1 1 0 G-2 and S-phase expressed 1 SOBP PF15279.1 EFE40886.1 - 0.26 11.6 3.3 0.29 11.4 2.3 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Herpes_DNAp_acc PF04929.7 EFE40886.1 - 1.2 7.9 5.5 1.5 7.7 3.8 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Corona_nucleoca PF00937.13 EFE40886.1 - 1.6 7.6 12.6 2 7.2 8.7 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Herpes_capsid PF06112.6 EFE40886.1 - 1.6 8.7 11.7 2.2 8.3 8.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Med3 PF11593.3 EFE40886.1 - 2.4 7.3 8.7 2.9 7.0 6.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Abhydrolase_6 PF12697.2 EFE40887.1 - 2.6e-16 60.2 0.3 1.3e-15 57.8 0.2 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE40887.1 - 1.1e-06 28.4 0.0 0.023 14.4 0.0 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE40887.1 - 3.3e-05 23.5 0.0 5.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ribosomal_L6 PF00347.18 EFE40888.1 - 1.9e-16 60.3 8.5 3.5e-10 40.2 0.6 3.7 3 1 0 3 3 3 2 Ribosomal protein L6 Glutaredoxin PF00462.19 EFE40888.1 - 7.7e-12 45.0 0.0 1.8e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin RXT2_N PF08595.6 EFE40889.1 - 3.6e-21 75.5 0.8 4e-14 52.6 0.0 3.9 4 0 0 4 4 4 2 RXT2-like, N-terminal PEMT PF04191.8 EFE40890.1 - 2.1e-28 98.5 7.9 4.5e-27 94.2 3.4 2.5 1 1 1 2 2 2 2 Phospholipid methyltransferase DUF4131 PF13567.1 EFE40890.1 - 0.071 12.5 2.8 0.071 12.5 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) UAA PF08449.6 EFE40890.1 - 0.11 11.4 2.5 0.17 10.7 1.8 1.3 1 0 0 1 1 1 0 UAA transporter family Steroid_dh PF02544.11 EFE40890.1 - 0.66 9.7 5.1 1 9.0 0.9 2.6 1 1 1 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase DUF924 PF06041.6 EFE40891.1 - 2.9e-47 160.8 0.1 3.4e-47 160.6 0.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) SUR7 PF06687.7 EFE40892.1 - 1.4e-36 126.0 9.3 2e-36 125.5 6.5 1.2 1 0 0 1 1 1 1 SUR7/PalI family Acetyltransf_1 PF00583.19 EFE40894.1 - 5.2e-14 52.0 0.0 7.3e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFE40894.1 - 3.6e-07 29.8 0.0 6.2e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EFE40894.1 - 0.00027 21.0 0.0 0.00046 20.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE40894.1 - 0.0041 16.9 0.1 0.0068 16.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFE40894.1 - 0.009 16.1 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Macoilin PF09726.4 EFE40895.1 - 5.2e-08 31.6 13.9 8.2e-08 31.0 9.6 1.3 1 0 0 1 1 1 1 Transmembrane protein DUF4646 PF15496.1 EFE40895.1 - 0.018 15.1 2.1 0.13 12.3 1.5 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4646) OmpH PF03938.9 EFE40895.1 - 1.2 9.0 32.8 1.1 9.1 10.8 3.6 4 0 0 4 4 4 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.4 EFE40895.1 - 1.4 7.3 27.2 0.036 12.5 5.2 2.8 3 0 0 3 3 3 0 Golgin subfamily A member 5 DUF106 PF01956.11 EFE40895.1 - 4.8 6.6 13.8 2 7.9 3.5 3.0 3 0 0 3 3 3 0 Integral membrane protein DUF106 V_ATPase_I PF01496.14 EFE40895.1 - 5.8 4.6 6.3 9.1 3.9 4.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HEAT PF02985.17 EFE40896.1 - 1.3e-08 34.2 3.2 0.079 13.0 0.0 5.4 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.1 EFE40896.1 - 3.1e-06 27.5 0.9 0.12 12.9 0.0 3.8 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.1 EFE40896.1 - 0.00069 19.8 0.1 0.18 12.0 0.1 3.6 2 1 1 3 3 3 1 HEAT repeats Cnd1 PF12717.2 EFE40896.1 - 0.029 14.2 0.0 0.13 12.1 0.0 1.9 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 EFE40896.1 - 0.052 11.8 0.0 1.2 7.3 0.0 2.0 1 1 2 3 3 3 0 Adaptin N terminal region CoA_trans PF01144.18 EFE40896.1 - 0.086 12.0 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase Pkinase PF00069.20 EFE40896.1 - 0.23 10.5 0.0 0.55 9.3 0.0 1.5 1 1 0 1 1 1 0 Protein kinase domain Ribonuclease PF00545.15 EFE40897.1 - 0.00085 19.3 1.4 0.0012 18.8 0.4 1.6 1 1 0 1 1 1 1 ribonuclease LsmAD PF06741.8 EFE40898.1 - 2.8e-26 91.3 5.9 2.8e-26 91.3 4.1 2.0 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.1 EFE40898.1 - 6.8e-09 35.5 0.0 2e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Ataxin 2 SM domain AIP3 PF03915.8 EFE40899.1 - 3.2e-153 510.6 4.5 3.2e-153 510.6 3.1 1.5 2 0 0 2 2 2 1 Actin interacting protein 3 Lectin_N PF03954.9 EFE40899.1 - 0.025 13.9 0.1 0.025 13.9 0.1 2.5 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain DUF3138 PF11336.3 EFE40899.1 - 0.07 11.3 1.4 0.12 10.5 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Syntaxin_2 PF14523.1 EFE40899.1 - 0.41 10.7 5.0 9.3 6.3 0.1 3.9 3 1 1 4 4 4 0 Syntaxin-like protein DUF1664 PF07889.7 EFE40899.1 - 5.4 6.8 8.7 0.32 10.7 0.4 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF3761 PF12587.3 EFE40900.1 - 0.47 10.6 4.7 0.4 10.8 1.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3761) ACOX PF01756.14 EFE40901.1 - 7.9e-35 119.9 0.0 1.6e-34 118.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.1 EFE40901.1 - 1.8e-29 102.5 0.7 3.4e-29 101.6 0.5 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.14 EFE40901.1 - 1.4e-11 43.7 0.3 3.5e-11 42.4 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.19 EFE40901.1 - 1.2e-07 31.9 0.0 0.00052 20.1 0.0 2.4 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain ESSS PF10183.4 EFE40902.1 - 2.3e-16 60.0 0.0 2.7e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) RNB PF00773.14 EFE40903.1 - 2e-94 316.5 0.1 4.5e-94 315.3 0.1 1.6 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 EFE40903.1 - 1.1e-11 44.9 0.6 3.4e-11 43.3 0.1 2.1 2 0 0 2 2 2 1 PIN domain MFS_1 PF07690.11 EFE40904.1 - 9.6e-20 70.5 49.0 4.2e-11 42.1 12.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LIM PF00412.17 EFE40905.1 - 4.9e-28 96.9 19.0 1.1e-10 41.3 2.0 3.9 3 1 0 3 3 3 3 LIM domain Zn_ribbon_recom PF13408.1 EFE40905.1 - 0.015 15.5 1.2 0.057 13.6 0.0 2.6 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Methyltransf_4 PF02390.12 EFE40906.1 - 1.5e-47 161.2 0.0 6.7e-47 159.1 0.0 1.8 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EFE40906.1 - 1.9e-05 25.2 0.0 3.2e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE40906.1 - 0.0013 18.7 0.0 0.0043 17.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE40906.1 - 0.005 17.1 0.0 0.014 15.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40906.1 - 0.0054 17.1 0.0 0.017 15.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE40906.1 - 0.0057 16.2 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 EFE40906.1 - 0.0059 15.6 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) MTS PF05175.9 EFE40906.1 - 0.0068 15.7 0.0 0.089 12.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.7 EFE40906.1 - 0.013 15.9 0.0 0.47 10.9 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain ESCRT-II PF05871.7 EFE40907.1 - 8.4e-52 174.7 1.0 1.3e-51 174.1 0.3 1.5 1 1 1 2 2 2 1 ESCRT-II complex subunit MNE1 PF13762.1 EFE40907.1 - 0.053 13.5 0.0 0.081 12.9 0.0 1.5 1 1 0 1 1 1 0 Mitochondrial splicing apparatus component CsgE PF10627.4 EFE40907.1 - 0.12 12.1 0.0 0.48 10.2 0.0 1.8 2 0 0 2 2 2 0 Curli assembly protein CsgE BRCT PF00533.21 EFE40908.1 - 6e-33 112.8 0.0 1.2e-07 31.7 0.0 6.4 6 0 0 6 6 6 6 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EFE40908.1 - 1.3e-27 95.4 0.8 2.7e-17 62.3 0.3 5.4 6 1 0 6 6 6 4 twin BRCT domain Abhydrolase_6 PF12697.2 EFE40909.1 - 8.2e-10 38.9 0.0 1.3e-06 28.4 0.0 2.4 2 1 0 2 2 2 2 Alpha/beta hydrolase family RTA1 PF04479.8 EFE40910.1 - 9.5e-10 38.3 4.4 4.2e-09 36.2 3.1 1.8 1 1 0 1 1 1 1 RTA1 like protein HAD PF12710.2 EFE40912.1 - 3.6e-06 27.2 0.0 4.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 EFE40912.1 - 0.00047 19.5 0.0 0.00061 19.1 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.1 EFE40912.1 - 0.0042 17.3 0.0 0.023 14.9 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HECT PF00632.20 EFE40913.1 - 2.8e-80 269.8 0.0 8.9e-80 268.1 0.0 1.8 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) HEAT PF02985.17 EFE40913.1 - 0.0099 15.8 1.9 0.82 9.9 0.1 4.3 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.15 EFE40913.1 - 0.014 13.7 3.0 0.02 13.2 0.0 2.5 3 0 0 3 3 3 0 Adaptin N terminal region Arm PF00514.18 EFE40913.1 - 0.029 14.2 6.5 8.7 6.3 0.1 5.7 5 1 1 6 6 6 0 Armadillo/beta-catenin-like repeat F-box-like PF12937.2 EFE40915.1 - 0.0046 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like FAM24 PF15193.1 EFE40916.1 - 2.7 8.2 6.0 21 5.3 0.1 2.9 3 0 0 3 3 3 0 FAM24 family COesterase PF00135.23 EFE40917.1 - 1e-82 278.5 0.0 1.3e-82 278.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE40917.1 - 1.7e-06 27.7 0.3 6.7e-06 25.8 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold EKR PF10371.4 EFE40917.1 - 0.048 13.2 0.1 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function F-actin_cap_A PF01267.12 EFE40918.1 - 2.4e-56 190.7 0.0 2.6e-56 190.6 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit PAP2 PF01569.16 EFE40921.1 - 1.2e-14 54.1 0.2 1.2e-14 54.1 0.1 2.8 2 1 1 3 3 3 2 PAP2 superfamily Sec62 PF03839.11 EFE40921.1 - 0.31 10.4 4.0 0.45 9.8 2.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Med7 PF05983.6 EFE40922.1 - 2.9e-47 160.4 0.0 5.7e-47 159.5 0.0 1.5 1 0 0 1 1 1 1 MED7 protein HEAT_2 PF13646.1 EFE40923.1 - 7.1e-20 71.0 1.5 3.6e-05 23.9 0.0 8.2 5 2 2 7 7 7 4 HEAT repeats HEAT PF02985.17 EFE40923.1 - 1.5e-19 68.2 6.2 0.00018 21.2 0.1 9.2 9 0 0 9 9 9 5 HEAT repeat HEAT_EZ PF13513.1 EFE40923.1 - 2.4e-17 62.8 3.3 0.0026 18.2 0.0 11.0 10 4 3 13 13 11 5 HEAT-like repeat Cnd1 PF12717.2 EFE40923.1 - 3.1e-07 30.3 2.9 0.087 12.6 0.1 4.3 5 0 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.2 EFE40923.1 - 5.2e-07 29.9 0.0 1.6 9.1 0.0 6.1 6 1 0 6 6 6 1 Vacuolar 14 Fab1-binding region UME PF08064.8 EFE40923.1 - 1.2e-05 25.1 0.0 0.38 10.7 0.0 4.8 5 0 0 5 5 5 2 UME (NUC010) domain MMS19_C PF12460.3 EFE40923.1 - 4.4e-05 22.4 1.0 0.002 16.9 0.0 3.4 3 2 1 4 4 4 1 RNAPII transcription regulator C-terminal IBN_N PF03810.14 EFE40923.1 - 8.4e-05 22.4 1.2 0.0003 20.6 0.2 2.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain ParcG PF10274.4 EFE40923.1 - 0.00044 20.1 0.0 0.021 14.7 0.0 2.8 2 0 0 2 2 2 1 Parkin co-regulated protein CLASP_N PF12348.3 EFE40923.1 - 0.0013 18.1 0.3 0.27 10.5 0.0 4.1 5 0 0 5 5 5 1 CLASP N terminal Adaptin_N PF01602.15 EFE40923.1 - 0.057 11.7 0.4 8.9 4.5 0.0 3.0 3 1 0 3 3 3 0 Adaptin N terminal region Xpo1 PF08389.7 EFE40923.1 - 0.063 13.1 0.2 2.9 7.8 0.0 3.7 4 0 0 4 4 4 0 Exportin 1-like protein Patched PF02460.13 EFE40924.1 - 2e-74 250.9 6.3 8.4e-74 248.9 4.4 1.7 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.3 EFE40924.1 - 1e-51 174.4 5.7 1e-51 174.4 4.0 3.0 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 EFE40924.1 - 2.9e-07 29.4 8.0 2.9e-07 29.4 5.5 3.8 4 1 0 4 4 4 1 MMPL family DUF2433 PF10360.4 EFE40926.1 - 3.5e-53 179.4 0.0 5.6e-53 178.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) DUF2360 PF10152.4 EFE40926.1 - 3.2 8.0 18.3 2.7e+02 1.7 10.4 3.4 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) PAP1 PF08601.5 EFE40927.1 - 9.6e-47 160.3 47.5 1.1e-26 94.4 24.9 4.4 3 1 0 3 3 3 2 Transcription factor PAP1 bZIP_1 PF00170.16 EFE40927.1 - 1.9e-08 34.1 8.1 4e-08 33.0 5.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor SlyX PF04102.7 EFE40927.1 - 0.012 16.0 0.3 0.028 14.8 0.2 1.6 1 0 0 1 1 1 0 SlyX bZIP_2 PF07716.10 EFE40927.1 - 0.014 15.2 11.1 0.014 15.2 7.7 2.2 2 1 1 3 3 3 0 Basic region leucine zipper DUF16 PF01519.11 EFE40927.1 - 0.017 15.3 1.5 0.032 14.4 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 COG7 PF10191.4 EFE40927.1 - 0.046 11.6 0.1 0.067 11.0 0.1 1.1 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) bZIP_Maf PF03131.12 EFE40927.1 - 0.14 12.4 10.1 0.38 11.0 7.0 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor IncA PF04156.9 EFE40927.1 - 0.19 11.3 3.7 0.3 10.6 2.6 1.3 1 0 0 1 1 1 0 IncA protein XhlA PF10779.4 EFE40927.1 - 0.37 10.7 3.1 0.9 9.4 2.2 1.6 1 0 0 1 1 1 0 Haemolysin XhlA DUF4537 PF15057.1 EFE40928.1 - 0.0089 15.8 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) DUF1325 PF07039.6 EFE40928.1 - 0.11 12.0 1.1 0.4 10.3 0.0 2.1 2 0 0 2 2 2 0 SGF29 tudor-like domain TRAUB PF08164.7 EFE40929.1 - 5.6e-33 112.9 0.1 2.6e-32 110.7 0.0 2.3 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.1 EFE40929.1 - 6.7e-30 103.9 1.9 6.7e-30 103.9 1.3 2.9 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor ParA PF10609.4 EFE40930.1 - 3.5e-33 113.3 0.0 6.9e-33 112.3 0.0 1.5 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EFE40930.1 - 4.5e-05 22.9 0.0 6.4e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Lar_restr_allev PF14354.1 EFE40930.1 - 0.075 13.3 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar Abhydrolase_3 PF07859.8 EFE40931.1 - 4.9e-25 88.3 0.5 3.1e-16 59.5 0.4 3.1 2 1 1 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 EFE40931.1 - 2.2e-14 52.8 0.0 7.4e-12 44.5 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF2424) WGG PF10273.4 EFE40932.1 - 2.8e-30 104.2 0.1 4.9e-30 103.4 0.1 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 DUF4255 PF14065.1 EFE40932.1 - 0.0085 15.5 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4255) RRP7 PF12923.2 EFE40932.1 - 0.096 12.7 1.0 0.12 12.3 0.1 1.6 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) NOA36 PF06524.7 EFE40932.1 - 1.6 7.9 5.7 1.9 7.6 3.9 1.1 1 0 0 1 1 1 0 NOA36 protein Tht1 PF04163.7 EFE40933.1 - 9.2e-09 34.2 8.5 6e-08 31.5 4.2 2.4 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein DASH_Dad1 PF08649.5 EFE40933.1 - 0.051 13.2 0.6 0.38 10.4 0.1 2.5 2 0 0 2 2 2 0 DASH complex subunit Dad1 Ssu72 PF04722.8 EFE40933.1 - 0.054 12.8 0.7 0.085 12.1 0.0 1.6 2 0 0 2 2 2 0 Ssu72-like protein Ribosomal_L6 PF00347.18 EFE40934.1 - 1.7e-20 73.2 0.0 9.6e-13 48.4 0.0 2.5 3 0 0 3 3 3 2 Ribosomal protein L6 Inositol_P PF00459.20 EFE40935.1 - 1.5e-52 178.5 0.4 2.9e-52 177.6 0.3 1.3 1 1 0 1 1 1 1 Inositol monophosphatase family VHS PF00790.14 EFE40936.1 - 6.9e-20 71.1 0.0 9.4e-14 51.2 0.0 2.4 2 0 0 2 2 2 2 VHS domain ENTH PF01417.15 EFE40936.1 - 0.0019 18.0 0.1 0.0074 16.1 0.0 2.0 2 1 0 2 2 2 1 ENTH domain ATG16 PF08614.6 EFE40936.1 - 0.0068 16.2 1.8 0.013 15.3 1.3 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Bys1 PF04681.7 EFE40936.1 - 0.015 15.0 0.9 0.025 14.2 0.6 1.3 1 0 0 1 1 1 0 Blastomyces yeast-phase-specific protein GAT PF03127.9 EFE40936.1 - 0.02 14.8 0.6 0.047 13.6 0.4 1.7 1 0 0 1 1 1 0 GAT domain adh_short PF00106.20 EFE40937.1 - 1.6e-22 80.1 1.9 8.8e-21 74.5 1.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE40937.1 - 1.2e-21 77.6 0.7 4.6e-20 72.4 0.5 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE40937.1 - 8.6e-10 38.5 1.5 2.9e-07 30.3 0.1 2.2 2 0 0 2 2 2 2 KR domain Pyr_redox PF00070.22 EFE40937.1 - 0.0054 17.0 0.8 0.068 13.5 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.21 EFE40937.1 - 0.019 14.4 0.2 0.056 12.9 0.2 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase PrpR_N PF06506.6 EFE40937.1 - 0.052 12.9 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Propionate catabolism activator Shikimate_DH PF01488.15 EFE40937.1 - 0.064 13.3 0.3 0.18 11.9 0.2 1.7 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase CP2 PF04516.10 EFE40938.1 - 8.2e-70 234.5 0.0 1.2e-69 233.9 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor DEAD PF00270.24 EFE40939.1 - 2.3e-43 147.6 0.1 4.9e-43 146.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE40939.1 - 8e-22 76.9 0.0 1.8e-21 75.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 EFE40939.1 - 0.0001 20.8 0.0 0.35 9.2 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF1253) SNF2_N PF00176.18 EFE40939.1 - 0.00024 20.0 0.0 0.00051 18.9 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EFE40939.1 - 0.001 18.9 0.3 0.0064 16.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFE40939.1 - 0.01 15.9 0.0 0.038 14.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain Pes-10 PF07149.6 EFE40939.1 - 3.5 6.2 6.2 0.91 8.2 1.1 2.0 2 0 0 2 2 2 0 Pes-10 Ank_2 PF12796.2 EFE40940.1 - 4.9e-18 65.2 0.0 3.1e-11 43.4 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFE40940.1 - 6.6e-13 47.7 0.3 0.0033 17.1 0.0 4.5 4 1 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 EFE40940.1 - 8.4e-13 48.4 0.0 7.5e-05 23.1 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE40940.1 - 6.1e-12 45.3 0.0 0.021 15.0 0.0 4.1 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE40940.1 - 6.2e-11 41.4 0.0 0.0062 16.6 0.0 4.8 4 1 0 4 4 4 3 Ankyrin repeat DUF3734 PF12536.3 EFE40940.1 - 0.048 13.7 0.0 3.4 7.8 0.0 2.1 2 0 0 2 2 2 0 Patatin phospholipase FtsJ PF01728.14 EFE40941.1 - 2.4e-62 210.1 0.0 2.9e-62 209.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 EFE40941.1 - 0.032 14.8 0.0 2.8 8.5 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain FAD_binding_1 PF00667.15 EFE40942.1 - 9.7e-53 178.8 0.0 1.4e-52 178.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 EFE40942.1 - 1.3e-11 45.0 0.0 4e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain MAT1 PF06391.8 EFE40944.1 - 2.1e-37 128.6 19.0 2.8e-37 128.2 13.1 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4 PF00097.20 EFE40944.1 - 0.00013 21.5 3.7 0.00034 20.1 2.6 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE40944.1 - 0.00035 20.1 5.2 0.00069 19.2 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE40944.1 - 0.0041 17.1 5.8 0.009 16.0 4.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE40944.1 - 0.009 15.7 7.1 0.057 13.1 5.3 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 EFE40944.1 - 0.017 14.9 5.9 0.032 14.0 4.1 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.1 EFE40944.1 - 0.018 14.5 5.3 0.084 12.4 1.4 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain TMF_TATA_bd PF12325.3 EFE40945.1 - 0.031 14.0 0.6 0.075 12.7 0.4 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Viral_P18 PF04521.8 EFE40945.1 - 0.25 10.7 0.8 0.66 9.4 0.6 1.6 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein LCD1 PF09798.4 EFE40945.1 - 0.29 9.0 0.2 0.4 8.6 0.1 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein adh_short PF00106.20 EFE40946.1 - 3.1e-12 46.7 0.0 5.1e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE40946.1 - 0.0018 17.9 0.1 0.0047 16.6 0.0 1.7 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.1 EFE40946.1 - 0.0052 16.8 0.0 0.0098 15.9 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding adh_short_C2 PF13561.1 EFE40946.1 - 0.02 14.6 0.1 0.044 13.5 0.0 1.6 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase F-box-like PF12937.2 EFE40948.1 - 6.8e-05 22.5 0.1 0.00015 21.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like NHR2 PF08788.6 EFE40948.1 - 0.1 12.1 0.1 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 NHR2 domain like Glyco_hydro_18 PF00704.23 EFE40949.1 - 1.5e-75 254.8 0.8 2.3e-75 254.1 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 EFE40949.1 - 1.6e-08 34.3 13.6 1.6e-08 34.3 9.4 4.0 4 1 0 4 4 4 1 Chitin recognition protein UPF0154 PF03672.8 EFE40949.1 - 0.074 12.6 1.2 0.16 11.6 0.9 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) PEX11 PF05648.9 EFE40951.1 - 1.7e-24 86.3 0.0 2e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) FMN_red PF03358.10 EFE40952.1 - 9.1e-09 34.9 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 EFE40952.1 - 5.3e-07 29.3 0.0 7.1e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.20 EFE40952.1 - 9.8e-07 28.8 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.2 EFE40952.1 - 0.0084 16.1 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain NPL4 PF05021.10 EFE40954.1 - 4.3e-129 430.0 0.0 5.5e-129 429.7 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 EFE40954.1 - 3.1e-70 234.5 0.2 5.4e-70 233.7 0.1 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region Kinesin PF00225.18 EFE40955.1 - 1.4e-115 385.6 0.1 2.1e-115 385.0 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain TSC22 PF01166.13 EFE40955.1 - 0.063 13.2 0.6 0.21 11.5 0.4 2.0 1 0 0 1 1 1 0 TSC-22/dip/bun family Tim17 PF02466.14 EFE40957.1 - 0.004 17.1 6.8 0.01 15.8 4.6 1.8 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF1324 PF07038.6 EFE40957.1 - 0.023 14.7 0.0 0.057 13.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1324) cNMP_binding PF00027.24 EFE40959.1 - 1.2e-35 121.2 0.0 3.5e-20 71.5 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.1 EFE40959.1 - 6.3e-13 47.3 12.3 0.069 13.2 0.0 9.5 10 0 0 10 10 10 3 Leucine Rich repeat LRR_1 PF00560.28 EFE40959.1 - 2.7e-07 29.6 7.8 7.6 7.0 0.0 8.8 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_8 PF13855.1 EFE40959.1 - 2.7e-06 27.0 0.4 0.017 14.9 0.5 5.1 4 1 1 5 5 5 1 Leucine rich repeat F-box-like PF12937.2 EFE40959.1 - 2.5e-05 23.9 0.6 2.5e-05 23.9 0.4 2.4 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 EFE40959.1 - 5.5e-05 22.7 1.1 5.5e-05 22.7 0.8 3.4 3 0 0 3 3 3 1 F-box domain LRR_7 PF13504.1 EFE40959.1 - 0.021 14.9 15.4 43 4.9 0.0 8.1 8 0 0 8 8 8 0 Leucine rich repeat Ste50p-SAM PF09235.5 EFE40959.1 - 0.075 13.0 3.4 7.9 6.5 0.4 4.1 3 2 0 3 3 3 0 Ste50p, sterile alpha motif LRR_4 PF12799.2 EFE40959.1 - 0.094 12.3 7.4 0.6 9.8 0.0 5.0 5 2 1 6 6 6 0 Leucine Rich repeats (2 copies) Cupin_3 PF05899.7 EFE40959.1 - 0.16 11.3 0.0 4.4 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF861) DUF1504 PF07399.6 EFE40961.1 - 0.081 11.5 0.0 0.096 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1504) Slx4 PF09494.5 EFE40962.1 - 3.1e-27 94.0 0.4 5.2e-27 93.3 0.3 1.4 1 0 0 1 1 1 1 Slx4 endonuclease Bax1-I PF01027.15 EFE40963.1 - 6.3e-28 97.7 12.3 6.3e-28 97.7 8.6 1.4 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 DUF2537 PF10801.3 EFE40963.1 - 0.18 11.9 6.1 3.3 7.8 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2537) Spectrin PF00435.16 EFE40964.1 - 0.23 11.7 3.0 7.1 6.9 0.4 2.5 1 1 1 2 2 2 0 Spectrin repeat Cutinase PF01083.17 EFE40965.1 - 2.2e-37 128.5 0.0 2.6e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Cutinase Abhydrolase_2 PF02230.11 EFE40965.1 - 0.0006 19.3 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase PE-PPE PF08237.6 EFE40965.1 - 0.08 12.3 0.1 0.26 10.6 0.0 1.9 1 1 0 1 1 1 0 PE-PPE domain Abhydrolase_1 PF00561.15 EFE40965.1 - 0.12 11.8 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Glyco_hydro_76 PF03663.9 EFE40966.1 - 7.7e-23 81.4 1.1 2.6e-15 56.6 0.0 2.8 3 1 1 4 4 4 2 Glycosyl hydrolase family 76 DUF2236 PF09995.4 EFE40967.1 - 3.2e-06 26.6 0.0 6.2e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Acetate_kinase PF00871.12 EFE40969.1 - 4.3e-70 236.2 0.2 9.3e-47 159.3 0.1 2.0 2 0 0 2 2 2 2 Acetokinase family XFP_N PF09364.5 EFE40970.1 - 7.8e-152 505.2 0.0 1.1e-151 504.7 0.0 1.2 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.10 EFE40970.1 - 1.2e-67 226.9 0.0 1.8e-67 226.3 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.5 EFE40970.1 - 8.8e-66 221.2 0.0 1.4e-65 220.5 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain SH3_9 PF14604.1 EFE40970.1 - 0.13 11.8 0.4 1 9.0 0.0 2.3 2 0 0 2 2 2 0 Variant SH3 domain Ribosomal_S7e PF01251.13 EFE40971.1 - 1e-73 246.9 1.6 6.9e-65 218.0 0.5 2.0 2 0 0 2 2 2 2 Ribosomal protein S7e Dynactin_p62 PF05502.8 EFE40972.1 - 1.8e-119 399.6 0.0 2.3e-119 399.3 0.0 1.0 1 0 0 1 1 1 1 Dynactin p62 family Methyltransf_11 PF08241.7 EFE40973.1 - 1.1e-07 32.2 0.0 2.2e-07 31.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40973.1 - 1.2e-06 28.3 0.0 2.7e-06 27.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE40973.1 - 4e-05 23.2 0.0 9.9e-05 21.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE40973.1 - 7.8e-05 23.0 0.0 0.00016 22.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE40973.1 - 0.023 13.8 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFE40973.1 - 0.057 13.7 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF2622 PF11080.3 EFE40973.1 - 0.13 12.1 0.0 0.83 9.5 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2622) P16-Arc PF04699.9 EFE40974.1 - 2.8e-59 199.5 0.0 3.3e-59 199.2 0.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) E1-E2_ATPase PF00122.15 EFE40975.1 - 4.6e-58 195.9 0.1 1e-57 194.8 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE40975.1 - 9e-46 155.6 8.2 9e-46 155.6 5.7 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE40975.1 - 1.7e-26 93.9 0.0 3.6e-26 92.9 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE40975.1 - 2.3e-16 59.5 0.0 4.6e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE40975.1 - 5.1e-12 46.3 0.0 1.3e-11 44.9 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFE40975.1 - 1.2e-08 34.2 0.1 6.5e-08 31.9 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EFE40975.1 - 3.1e-05 23.7 0.0 0.00086 18.9 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3325 PF11804.3 EFE40975.1 - 0.06 13.2 0.0 0.06 13.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3325) OST-HTH PF12872.2 EFE40976.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 OST-HTH/LOTUS domain DUF1448 PF07289.6 EFE40977.1 - 0.4 9.5 1.5 0.64 8.8 0.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1448) 3Beta_HSD PF01073.14 EFE40978.1 - 4.6e-54 183.0 0.0 6e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFE40978.1 - 1e-31 110.2 0.0 1.4e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFE40978.1 - 3.3e-11 42.5 0.8 6.3e-10 38.3 0.0 2.0 1 1 1 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.1 EFE40978.1 - 8.1e-10 38.9 0.0 1.3e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 EFE40978.1 - 2.9e-09 36.2 0.0 4.4e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EFE40978.1 - 1.4e-05 24.1 0.2 0.0001 21.3 0.1 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.5 EFE40978.1 - 0.0003 20.5 0.2 0.0026 17.4 0.1 2.2 1 1 0 1 1 1 1 KR domain adh_short PF00106.20 EFE40978.1 - 0.00051 20.0 0.2 0.0021 18.0 0.2 1.9 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 EFE40978.1 - 0.0069 15.6 0.2 0.012 14.8 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family TrkA_N PF02254.13 EFE40978.1 - 0.032 14.2 0.3 0.064 13.2 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain Transket_pyr PF02779.19 EFE40979.1 - 1.3e-42 145.3 0.0 2.1e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EFE40979.1 - 4.6e-31 107.3 0.0 1.6e-30 105.6 0.0 1.9 2 0 0 2 2 2 1 Transketolase, C-terminal domain PSI_PsaF PF02507.10 EFE40980.1 - 0.3 10.5 1.9 1.1 8.7 1.3 2.0 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Filament PF00038.16 EFE40980.1 - 5.2 6.4 60.4 0.13 11.6 27.2 2.1 2 0 0 2 2 2 0 Intermediate filament protein DUF21 PF01595.15 EFE40981.1 - 8e-26 90.4 0.1 1.2e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 EFE40981.1 - 0.00015 21.4 0.6 0.081 12.7 0.0 2.7 2 0 0 2 2 2 2 CBS domain His_Phos_1 PF00300.17 EFE40982.1 - 1.7e-12 47.6 0.1 3.8e-12 46.5 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) HECT PF00632.20 EFE40983.1 - 2.2e-53 181.4 0.0 3.9e-53 180.6 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-C2H2_2 PF12756.2 EFE40984.1 - 7e-35 119.1 20.8 2.7e-30 104.4 2.2 3.8 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 EFE40984.1 - 6.9e-08 32.4 13.0 2.1e-05 24.5 1.9 3.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EFE40984.1 - 8.1e-07 29.0 5.0 0.00025 21.0 1.4 4.5 5 0 0 5 5 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFE40984.1 - 8.6e-05 22.2 4.6 0.0059 16.4 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger DUF2024 PF09630.5 EFE40984.1 - 0.0011 18.6 1.1 0.012 15.2 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF2024) Cytochrome_CBB3 PF13442.1 EFE40984.1 - 0.03 14.4 2.5 5.1 7.3 0.2 2.9 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III GOLD_2 PF13897.1 EFE40984.1 - 0.076 13.2 1.1 0.28 11.4 0.8 2.0 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF693 PF05113.8 EFE40984.1 - 0.14 11.0 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF693) InvH PF04741.7 EFE40984.1 - 0.73 9.6 3.7 16 5.3 0.1 2.6 3 0 0 3 3 3 0 InvH outer membrane lipoprotein AKAP95 PF04988.7 EFE40984.1 - 2.8 7.7 7.6 1.2 8.8 0.7 3.2 2 2 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-FCS PF06467.9 EFE40984.1 - 3.6 7.2 8.4 1.8 8.2 0.1 3.0 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif Nucleo_P87 PF07267.6 EFE40985.1 - 2.3 6.8 8.7 4 5.9 6.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4407 PF14362.1 EFE40985.1 - 5.7 5.7 7.6 8.4 5.2 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Abhydrolase_3 PF07859.8 EFE40986.1 - 3.3e-06 26.8 0.0 7.7e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.13 EFE40986.1 - 0.00028 20.4 0.0 0.00049 19.5 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.16 EFE40986.1 - 0.00064 19.0 0.0 0.0015 17.7 0.0 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFE40986.1 - 0.0086 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE40986.1 - 0.054 13.3 0.0 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.20 EFE40987.1 - 1.2e-70 237.6 0.0 1.5e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE40987.1 - 1.6e-31 109.2 0.0 2.1e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE40987.1 - 0.00035 19.6 0.0 0.00056 18.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE40987.1 - 0.0045 16.7 0.0 0.0072 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFE40987.1 - 0.023 13.5 0.0 0.036 12.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.4 EFE40987.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL 2OG-FeII_Oxy_2 PF13532.1 EFE40988.1 - 1e-30 107.0 0.0 4.2e-30 105.0 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 EFE40988.1 - 0.095 13.2 0.0 0.29 11.6 0.0 1.8 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily ZU5 PF00791.15 EFE40989.1 - 0.035 13.7 0.0 0.092 12.4 0.0 1.7 2 0 0 2 2 2 0 ZU5 domain zf-C2HC_2 PF13913.1 EFE40990.1 - 0.0033 17.0 0.0 0.0073 15.9 0.0 1.5 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-Di19 PF05605.7 EFE40990.1 - 0.0075 16.3 0.1 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 EFE40990.1 - 0.018 15.3 0.4 0.058 13.7 0.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE40990.1 - 0.082 13.2 0.4 0.2 12.0 0.3 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type AAA_13 PF13166.1 EFE40990.1 - 5.2 5.3 6.7 10 4.4 0.0 2.3 3 0 0 3 3 3 0 AAA domain MFS_1 PF07690.11 EFE40992.1 - 1.2e-38 132.7 41.7 1.2e-38 132.7 28.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE40992.1 - 4.7e-09 35.3 15.4 4.7e-09 35.3 10.7 2.9 2 2 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 EFE40992.1 - 0.0029 15.8 6.4 0.0029 15.8 4.4 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PepSY_TM_2 PF13703.1 EFE40992.1 - 0.025 14.7 0.2 0.025 14.7 0.2 4.9 6 1 0 6 6 6 0 PepSY-associated TM helix Fungal_trans PF04082.13 EFE40993.1 - 6.2e-16 58.0 0.0 1.4e-15 56.8 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.21 EFE40994.1 - 1.8e-68 230.7 0.0 4.2e-68 229.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFE40994.1 - 1.8e-47 162.2 0.5 9.5e-47 159.8 0.1 2.1 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.1 EFE40994.1 - 2.8e-45 154.7 0.0 5.2e-45 153.8 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.5 EFE40994.1 - 2e-43 148.1 0.0 3.8e-43 147.2 0.0 1.5 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 EFE40994.1 - 7.2e-36 123.6 0.0 1.4e-35 122.6 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFE40994.1 - 4e-29 100.8 0.1 1.2e-28 99.2 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.7 EFE40994.1 - 3.8e-19 68.9 0.0 1.3e-18 67.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE40994.1 - 1.5e-12 47.7 0.0 4.2e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE40994.1 - 1.2e-11 44.6 0.0 2.8e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE40994.1 - 7.2e-10 38.6 0.0 2.3e-09 37.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE40994.1 - 2.3e-08 34.6 0.0 7.3e-08 32.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE40994.1 - 7.9e-06 26.1 0.0 2.6e-05 24.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE40994.1 - 1.1e-05 24.7 0.0 2.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.20 EFE40994.1 - 3.5e-05 23.9 0.3 0.00011 22.4 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 EFE40994.1 - 6.8e-05 21.9 0.0 0.00015 20.8 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_26 PF13659.1 EFE40994.1 - 0.00046 20.2 0.0 0.0014 18.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EFE40994.1 - 0.0073 15.7 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_28 PF02636.12 EFE40994.1 - 0.029 13.7 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase NodS PF05401.6 EFE40994.1 - 0.059 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) AA_permease_2 PF13520.1 EFE40995.1 - 5.2e-53 180.1 49.1 6.4e-53 179.8 34.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE40995.1 - 2e-22 79.2 40.9 2.6e-22 78.8 28.4 1.1 1 0 0 1 1 1 1 Amino acid permease Plasmod_dom_1 PF09715.5 EFE40995.1 - 0.087 12.7 0.3 0.43 10.5 0.2 2.3 1 0 0 1 1 1 0 Plasmodium protein of unknown function (Plasmod_dom_1) GSDH PF07995.6 EFE40996.1 - 0.0091 15.1 0.1 0.014 14.4 0.1 1.3 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase DUF3237 PF11578.3 EFE40998.1 - 2e-08 33.6 0.1 4.2e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) DLH PF01738.13 EFE40999.1 - 5.4e-13 48.7 0.0 6.3e-13 48.5 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.15 EFE40999.1 - 0.028 14.0 0.0 0.05 13.1 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold Cu-oxidase_3 PF07732.10 EFE41000.1 - 2.3e-45 153.1 0.1 3.7e-44 149.2 0.1 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFE41000.1 - 1.2e-38 131.7 5.6 2.2e-35 121.1 0.1 3.9 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.17 EFE41000.1 - 8.2e-33 113.5 0.3 2.5e-32 112.0 0.0 2.0 3 0 0 3 3 3 1 Multicopper oxidase CHB_HEX_C_1 PF13290.1 EFE41001.1 - 0.87 9.4 4.9 1.6 8.5 0.7 2.9 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain MFS_1 PF07690.11 EFE41002.1 - 3.9e-20 71.8 54.2 1.2e-10 40.6 7.9 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF4233 PF14017.1 EFE41002.1 - 0.0064 16.3 1.3 0.0064 16.3 0.9 3.2 4 1 0 4 4 4 1 Protein of unknown function (DUF4233) FAD_binding_4 PF01565.18 EFE41003.1 - 1e-21 76.8 0.5 1.7e-21 76.1 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE41003.1 - 0.014 15.3 0.1 0.072 13.0 0.0 2.3 3 0 0 3 3 3 0 Berberine and berberine like Stm1_N PF09598.5 EFE41004.1 - 9.1 7.0 9.5 19 6.0 5.1 2.5 1 1 1 2 2 2 0 Stm1 RCR PF12273.3 EFE41006.1 - 0.00047 20.7 0.6 0.00079 19.9 0.4 1.3 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red TMEM154 PF15102.1 EFE41006.1 - 0.035 13.7 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Med8 PF10232.4 EFE41007.1 - 2e-40 138.7 0.4 2.6e-40 138.3 0.3 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 PQ-loop PF04193.9 EFE41008.1 - 8.9e-18 63.6 8.4 1.2e-12 47.2 1.1 3.2 4 0 0 4 4 4 2 PQ loop repeat DUF3464 PF11947.3 EFE41008.1 - 5.2 6.5 6.0 3.5 7.0 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3464) UbiA PF01040.13 EFE41009.1 - 4e-29 101.6 20.0 4e-29 101.6 13.9 1.5 1 1 0 1 1 1 1 UbiA prenyltransferase family Fungal_trans_2 PF11951.3 EFE41010.1 - 0.0097 14.5 0.2 0.013 14.1 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box PF00646.28 EFE41011.1 - 0.26 11.0 0.1 0.26 11.0 0.1 3.1 3 0 0 3 3 3 0 F-box domain CTP_transf_2 PF01467.21 EFE41012.1 - 0.00044 20.3 0.1 0.99 9.4 0.2 2.4 2 0 0 2 2 2 2 Cytidylyltransferase WD40 PF00400.27 EFE41013.1 - 2.1e-23 81.2 9.9 2e-08 33.7 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat TFIIA PF03153.8 EFE41013.1 - 0.76 9.6 19.1 1.4 8.7 13.2 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit mRNA_triPase PF02940.10 EFE41014.1 - 6.3e-56 189.5 0.0 1e-55 188.8 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Kelch_3 PF13415.1 EFE41015.1 - 1.7e-20 72.6 6.6 1.4e-10 40.9 0.0 5.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.1 EFE41015.1 - 8.7e-19 67.0 0.8 1.1e-07 31.5 0.0 5.6 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_1 PF01344.20 EFE41015.1 - 5e-10 38.7 0.0 0.013 14.9 0.0 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 EFE41015.1 - 2.8e-09 36.7 2.6 0.12 12.6 0.3 5.6 4 1 0 4 4 4 2 Kelch motif Kelch_5 PF13854.1 EFE41015.1 - 1.7e-07 31.0 5.7 0.0092 15.9 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.10 EFE41015.1 - 4.1e-05 23.1 9.9 0.0023 17.6 0.0 5.6 7 0 0 7 7 7 1 Kelch motif BTB PF00651.26 EFE41015.1 - 0.21 11.5 0.0 0.79 9.7 0.0 1.9 2 0 0 2 2 2 0 BTB/POZ domain AhpC-TSA PF00578.16 EFE41016.1 - 1.5e-30 105.4 0.0 2.5e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EFE41016.1 - 7.7e-12 44.9 0.0 9.7e-11 41.4 0.0 2.2 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.4 EFE41016.1 - 7.8e-09 35.0 0.1 1.4e-08 34.2 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SR-25 PF10500.4 EFE41016.1 - 4.4 6.6 11.7 6.9 6.0 8.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein His_Phos_2 PF00328.17 EFE41017.1 - 2.2e-53 181.8 0.0 2.5e-53 181.6 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) bZIP_2 PF07716.10 EFE41018.1 - 2.2e-05 24.1 10.5 3.6e-05 23.5 7.3 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EFE41018.1 - 0.25 11.3 12.0 0.48 10.4 8.3 1.4 1 1 0 1 1 1 0 bZIP transcription factor APH PF01636.18 EFE41021.1 - 5.9e-14 52.3 0.1 2e-13 50.6 0.0 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE41021.1 - 0.0055 15.3 0.0 0.23 10.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Amidoligase_2 PF12224.3 EFE41022.1 - 1.7e-16 60.6 0.0 4.5e-16 59.2 0.0 1.7 1 1 0 1 1 1 1 Putative amidoligase enzyme MFS_1 PF07690.11 EFE41023.1 - 5.6e-12 45.0 40.8 7e-12 44.7 27.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFE41023.1 - 5.3e-08 32.5 6.0 5.3e-08 32.5 4.2 2.9 3 1 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sas10_Utp3 PF04000.10 EFE41024.1 - 1.4e-18 66.8 2.0 2.8e-18 65.8 1.4 1.6 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Ebola_NP PF05505.7 EFE41024.1 - 0.28 9.2 6.3 0.36 8.8 4.4 1.2 1 0 0 1 1 1 0 Ebola nucleoprotein Pyr_redox_3 PF13738.1 EFE41026.1 - 1.3e-18 67.8 0.0 3.6e-18 66.3 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFE41026.1 - 3.1e-15 55.3 0.0 7e-15 54.2 0.0 1.5 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EFE41026.1 - 2.4e-12 47.1 0.0 1.9e-10 40.9 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE41026.1 - 2.3e-10 39.9 0.0 7.8e-08 31.6 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFE41026.1 - 1.1e-07 31.7 1.5 4.5e-06 26.6 0.0 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFE41026.1 - 5.3e-07 29.9 3.2 0.014 15.8 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFE41026.1 - 7.9e-05 21.7 0.2 0.00047 19.1 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFE41026.1 - 0.00027 20.7 2.4 0.025 14.3 0.0 3.2 4 0 0 4 4 4 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.16 EFE41026.1 - 0.0012 18.4 0.3 0.11 12.0 0.0 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.1 EFE41026.1 - 0.0019 18.4 0.1 0.03 14.5 0.1 2.4 2 1 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.15 EFE41026.1 - 0.0023 18.0 0.2 0.32 11.1 0.0 2.6 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 EFE41026.1 - 0.0025 17.4 0.0 0.0045 16.6 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.19 EFE41026.1 - 0.029 13.2 0.2 0.029 13.2 0.1 1.6 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.9 EFE41026.1 - 0.098 11.1 1.0 0.88 7.9 0.0 2.5 3 0 0 3 3 3 0 HI0933-like protein GIDA PF01134.17 EFE41026.1 - 6.1 5.5 5.9 0.8 8.4 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NmrA PF05368.8 EFE41027.1 - 1.5e-36 125.8 0.0 2.3e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFE41027.1 - 8e-13 48.7 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Semialdhyde_dh PF01118.19 EFE41027.1 - 0.0015 18.8 0.0 0.0028 17.9 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.13 EFE41027.1 - 0.055 13.4 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain 3Beta_HSD PF01073.14 EFE41027.1 - 0.073 11.7 0.0 0.24 10.0 0.0 1.8 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Pkinase PF00069.20 EFE41028.1 - 3.2e-32 111.7 0.0 4.4e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41028.1 - 4.2e-06 26.0 0.0 0.011 14.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 EFE41029.1 - 6.3e-10 39.1 0.0 2e-09 37.5 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE41029.1 - 0.0022 17.6 0.1 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Sugarporin_N PF11471.3 EFE41029.1 - 0.077 12.6 0.8 0.16 11.6 0.6 1.5 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Fungal_trans PF04082.13 EFE41032.1 - 2.4e-14 52.8 0.2 3.6e-14 52.2 0.1 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.20 EFE41033.1 - 0.0034 17.3 0.0 0.0067 16.3 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase Transferase PF02458.10 EFE41034.1 - 2e-08 33.1 0.1 8e-07 27.8 0.1 2.2 1 1 0 1 1 1 1 Transferase family MFS_1 PF07690.11 EFE41035.1 - 1.2e-31 109.7 49.8 1.2e-31 109.7 34.5 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE41035.1 - 1.5e-20 72.9 15.4 1.9e-20 72.6 10.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE41035.1 - 2.1e-12 46.4 10.2 2.1e-12 46.4 7.1 2.0 2 1 1 3 3 3 1 Sugar (and other) transporter Epiglycanin_C PF14654.1 EFE41035.1 - 0.089 12.8 0.4 0.74 9.8 0.0 2.7 3 0 0 3 3 3 0 Mucin, catalytic, TM and cytoplasmic tail region DUF4407 PF14362.1 EFE41035.1 - 0.22 10.4 0.5 0.5 9.2 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PhyH PF05721.8 EFE41036.1 - 1.3e-24 87.3 0.0 2e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HNH_2 PF13391.1 EFE41037.1 - 2e-10 40.3 0.0 5.4e-10 38.9 0.0 1.8 1 0 0 1 1 1 1 HNH endonuclease Lipoprotein_10 PF03202.8 EFE41037.1 - 0.015 15.3 0.3 0.023 14.6 0.2 1.3 1 0 0 1 1 1 0 Putative mycoplasma lipoprotein, C-terminal region ketoacyl-synt PF00109.21 EFE41038.1 - 1.4e-68 231.1 2.0 2.8e-68 230.1 0.1 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFE41038.1 - 3.4e-67 227.0 0.1 5.2e-67 226.4 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 EFE41038.1 - 8e-56 188.5 1.2 2.8e-55 186.7 0.8 2.0 1 0 0 1 1 1 1 KR domain PS-DH PF14765.1 EFE41038.1 - 1.5e-55 188.4 0.0 2.5e-55 187.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 EFE41038.1 - 1.6e-41 141.9 0.3 5.6e-41 140.2 0.2 2.0 1 0 0 1 1 1 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFE41038.1 - 2e-32 111.5 0.2 5.8e-32 110.0 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.21 EFE41038.1 - 6.6e-17 61.2 0.0 1.7e-16 59.9 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.1 EFE41038.1 - 3.6e-08 33.2 0.0 1.3e-07 31.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.20 EFE41038.1 - 5.9e-08 32.8 0.2 2.5e-07 30.8 0.1 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.1 EFE41038.1 - 1.8e-07 32.1 0.0 8.7e-07 29.8 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 EFE41038.1 - 1.1e-06 29.0 0.0 3.9e-06 27.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.7 EFE41038.1 - 4.7e-06 26.3 0.0 1.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_31 PF13847.1 EFE41038.1 - 1.1e-05 25.0 0.0 2.9e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE41038.1 - 2.2e-05 24.9 0.0 6.7e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.18 EFE41038.1 - 0.00023 20.2 0.3 0.00049 19.1 0.2 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.7 EFE41038.1 - 0.0014 19.0 0.0 0.0051 17.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 EFE41038.1 - 0.24 10.2 0.0 0.56 9.0 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase Aminotran_1_2 PF00155.16 EFE41039.1 - 1.8e-23 83.0 0.0 2.2e-18 66.3 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EFE41039.1 - 5.1e-06 25.7 0.1 6.5e-05 22.1 0.0 2.3 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 EFE41039.1 - 3.7e-05 22.9 0.0 5.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EFE41039.1 - 4.5e-05 21.9 0.1 7.3e-05 21.2 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.16 EFE41039.1 - 0.001 18.0 0.0 0.0071 15.2 0.0 2.2 2 0 0 2 2 2 1 Aminotransferase class-III SHMT PF00464.14 EFE41039.1 - 0.0018 16.7 0.2 0.0027 16.1 0.1 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase OKR_DC_1 PF01276.15 EFE41039.1 - 0.05 12.1 0.1 0.95 7.9 0.0 2.0 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, major domain p450 PF00067.17 EFE41040.1 - 1.2e-73 248.2 0.0 1.5e-73 247.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 EMP70 PF02990.11 EFE41041.1 - 5.6e-181 602.5 3.2 5.6e-181 602.5 2.2 1.4 2 0 0 2 2 2 1 Endomembrane protein 70 EF-hand_7 PF13499.1 EFE41042.1 - 3.4e-29 100.7 5.2 3.5e-13 49.4 0.2 2.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 EFE41042.1 - 3.8e-26 88.3 8.7 3.9e-08 32.0 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 EFE41042.1 - 3.1e-24 82.6 0.6 3.2e-06 26.5 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 EFE41042.1 - 3.9e-20 70.1 7.2 1.5e-05 24.0 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 EFE41042.1 - 7.7e-16 57.4 11.0 3.6e-06 26.4 0.9 4.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 EFE41042.1 - 7.3e-09 35.2 3.4 0.0012 18.5 0.1 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 EFE41042.1 - 0.0043 16.9 0.1 0.43 10.5 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_10 PF14788.1 EFE41042.1 - 0.0078 15.8 0.4 1.7 8.3 0.0 3.3 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.4 EFE41042.1 - 0.021 14.8 0.2 0.53 10.3 0.1 2.7 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Mad3_BUB1_II PF08171.6 EFE41042.1 - 0.059 13.2 0.0 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Mad3/BUB1 homology region 2 Med4 PF10018.4 EFE41043.1 - 5.7e-33 113.8 0.9 1.9e-32 112.2 0.3 2.0 2 1 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF3245 PF11595.3 EFE41043.1 - 0.022 15.0 5.4 0.64 10.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) Ada3 PF10198.4 EFE41043.1 - 0.49 10.1 3.7 0.68 9.6 0.8 2.4 3 0 0 3 3 3 0 Histone acetyltransferases subunit 3 ATG16 PF08614.6 EFE41043.1 - 0.72 9.6 5.6 0.11 12.2 0.5 2.0 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) MFS_1 PF07690.11 EFE41044.1 - 8.3e-28 97.1 35.8 2.7e-27 95.4 24.6 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily RabGAP-TBC PF00566.13 EFE41045.1 - 2.8e-48 164.2 1.4 1.3e-47 162.0 0.0 2.5 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF1664 PF07889.7 EFE41045.1 - 2.2 8.0 9.7 0.08 12.7 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.6 EFE41045.1 - 4.3 7.3 7.0 2.7 7.9 1.4 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2570 PF10828.3 EFE41045.1 - 4.7 6.8 15.0 0.38 10.3 2.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) Acyl-CoA_dh_N PF02771.11 EFE41046.1 - 1.7e-22 80.1 0.2 3.2e-22 79.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.19 EFE41046.1 - 1.8e-20 73.5 0.8 1.8e-20 73.5 0.6 1.5 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.6 EFE41046.1 - 3.9e-08 33.6 2.8 3.9e-08 33.6 2.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Reticulon PF02453.12 EFE41047.1 - 2.6e-13 49.9 5.5 3.6e-09 36.4 0.9 2.3 1 1 1 2 2 2 2 Reticulon Phasin_2 PF09361.5 EFE41047.1 - 0.061 13.3 2.3 0.15 12.0 0.4 2.2 2 0 0 2 2 2 0 Phasin protein DNA_topoisoIV PF00521.15 EFE41050.1 - 2.5e-134 448.3 0.1 5.2e-134 447.2 0.1 1.6 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 EFE41050.1 - 1.3e-34 118.9 2.3 3.5e-34 117.5 1.6 1.8 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 EFE41050.1 - 5.8e-13 48.6 0.1 3.9e-12 46.0 0.0 2.5 2 0 0 2 2 2 1 Toprim domain HATPase_c PF02518.21 EFE41050.1 - 3.9e-11 42.6 0.0 1.2e-10 41.0 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase INCENP_ARK-bind PF03941.10 EFE41051.1 - 1.1e-18 66.8 0.4 1.1e-18 66.8 0.2 2.4 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region PDZ_1 PF12812.2 EFE41052.1 - 2.2e-53 178.0 0.0 4.9e-34 116.0 0.0 3.3 3 0 0 3 3 3 2 PDZ-like domain PDZ_2 PF13180.1 EFE41052.1 - 5.3e-15 55.0 0.1 3.6e-06 26.7 0.0 3.8 3 0 0 3 3 3 3 PDZ domain Trypsin_2 PF13365.1 EFE41052.1 - 3.8e-13 49.4 0.0 1.2e-12 47.8 0.0 1.9 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ PF00595.19 EFE41052.1 - 1.2e-10 41.3 0.0 0.00021 21.4 0.0 3.7 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) Trypsin PF00089.21 EFE41052.1 - 4.9e-05 23.0 0.0 0.00017 21.2 0.0 1.8 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.1 EFE41052.1 - 0.0016 18.1 0.1 0.15 11.8 0.1 3.4 4 0 0 4 4 4 1 Tricorn protease PDZ domain DUF31 PF01732.11 EFE41052.1 - 0.096 11.9 0.4 0.15 11.3 0.2 1.3 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S7 PF00949.16 EFE41052.1 - 0.2 11.0 0.1 0.43 9.9 0.1 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.4 EFE41052.1 - 0.38 9.1 1.0 0.69 8.2 0.1 1.7 2 0 0 2 2 2 0 Peptidase S46 Lactamase_B PF00753.22 EFE41054.1 - 1.5e-05 24.7 0.1 2.6e-05 23.9 0.1 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily But2 PF09792.4 EFE41055.1 - 2.3e-51 173.3 0.2 2.8e-51 173.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain PAP2 PF01569.16 EFE41056.1 - 4.3e-21 74.9 3.2 7.2e-20 70.9 2.2 2.1 1 1 0 1 1 1 1 PAP2 superfamily Perilipin PF03036.11 EFE41057.1 - 0.028 13.2 0.0 0.028 13.2 0.0 1.0 1 0 0 1 1 1 0 Perilipin family NST1 PF13945.1 EFE41057.1 - 0.044 13.8 1.8 0.044 13.8 1.3 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Trypsin PF00089.21 EFE41058.1 - 0.049 13.2 0.1 0.05 13.1 0.1 1.1 1 0 0 1 1 1 0 Trypsin SAGA-Tad1 PF12767.2 EFE41058.1 - 0.18 11.4 1.9 0.23 11.1 1.3 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF601 PF04642.7 EFE41058.1 - 0.32 10.3 10.6 0.34 10.2 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DTHCT PF08070.6 EFE41058.1 - 1 10.0 11.7 1.9 9.1 8.1 1.5 1 1 0 1 1 1 0 DTHCT (NUC029) region MARVEL PF01284.18 EFE41059.1 - 0.001 18.9 3.9 0.0012 18.6 2.6 1.3 1 1 0 1 1 1 1 Membrane-associating domain Kei1 PF08552.6 EFE41059.1 - 0.0072 16.0 0.0 0.01 15.4 0.0 1.4 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 DUF4282 PF14110.1 EFE41059.1 - 0.085 13.0 4.0 0.82 9.8 2.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) UPF0182 PF03699.8 EFE41059.1 - 0.14 10.0 0.6 0.19 9.6 0.2 1.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) Aminotran_5 PF00266.14 EFE41060.1 - 9.3e-27 93.7 0.0 1.3e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V MOSC_N PF03476.11 EFE41060.1 - 4.5e-24 84.4 0.0 8.1e-24 83.6 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 EFE41060.1 - 2.9e-19 68.8 0.0 5.3e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 MOSC domain Fe_hyd_SSU PF02256.12 EFE41062.1 - 0.095 12.7 0.1 0.21 11.6 0.0 1.5 2 0 0 2 2 2 0 Iron hydrogenase small subunit FAT PF02259.18 EFE41063.1 - 0.006 15.6 1.1 0.014 14.4 0.1 2.0 2 1 0 2 2 2 1 FAT domain TPR_14 PF13428.1 EFE41063.1 - 0.0087 16.6 8.7 0.052 14.2 0.1 4.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFE41063.1 - 0.013 15.7 0.2 25 5.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat FAD_binding_4 PF01565.18 EFE41064.1 - 2.5e-15 56.1 6.9 2.3e-10 40.0 1.9 3.2 1 1 1 2 2 2 2 FAD binding domain BBE PF08031.7 EFE41064.1 - 0.098 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like PNPase_C PF12111.3 EFE41064.1 - 1.7 7.8 5.7 2.3 7.5 1.8 2.4 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal p450 PF00067.17 EFE41065.1 - 2e-13 49.6 0.2 6.8e-11 41.3 0.1 2.0 2 0 0 2 2 2 2 Cytochrome P450 DEAD PF00270.24 EFE41068.1 - 2.7e-40 137.6 0.0 2.1e-39 134.7 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE41068.1 - 7.1e-26 89.8 0.2 1.7e-25 88.6 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2984 PF11203.3 EFE41068.1 - 0.048 13.7 1.8 0.12 12.5 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2984) PRAI PF00697.17 EFE41068.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase DUF2986 PF11661.3 EFE41068.1 - 0.32 11.3 9.0 0.05 13.9 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) Peptidase_M1 PF01433.15 EFE41069.1 - 2.3e-141 471.4 1.7 3.1e-141 470.9 1.2 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 EFE41069.1 - 2e-91 306.6 1.1 6.2e-91 305.0 0.1 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EFE41069.1 - 4.4e-20 72.0 0.4 8e-20 71.1 0.3 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily AA_permease_2 PF13520.1 EFE41071.1 - 8.4e-95 317.8 37.5 1.3e-94 317.1 26.0 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE41071.1 - 3.5e-25 88.2 32.7 9.7e-25 86.8 22.8 1.6 1 1 0 1 1 1 1 Amino acid permease DUF3543 PF12063.3 EFE41072.1 - 9.7e-88 293.3 0.2 6.8e-87 290.6 0.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.20 EFE41072.1 - 1.3e-62 211.2 0.0 5.5e-62 209.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41072.1 - 8e-43 146.3 0.0 2.4e-42 144.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE41072.1 - 0.02 13.8 0.0 1.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Kinase-like PAZ PF02170.17 EFE41072.1 - 0.02 14.2 0.1 0.048 12.9 0.0 1.6 1 0 0 1 1 1 0 PAZ domain APH PF01636.18 EFE41072.1 - 0.071 12.8 2.8 0.13 11.9 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family CTP_transf_1 PF01148.15 EFE41074.1 - 1.7e-05 24.6 12.7 1.7e-05 24.6 8.8 3.7 2 2 0 2 2 2 1 Cytidylyltransferase family ATP_bind_4 PF01902.12 EFE41076.1 - 8.8e-19 67.7 0.0 2.3e-05 23.8 0.0 4.2 2 1 1 3 3 3 3 ATP-binding region Ribonuc_L-PSP PF01042.16 EFE41076.1 - 2.5e-11 43.4 0.0 9.2e-06 25.4 0.0 3.5 3 1 0 3 3 3 2 Endoribonuclease L-PSP zf-C2H2 PF00096.21 EFE41077.1 - 5.5e-10 39.0 20.4 1.3e-06 28.3 0.7 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE41077.1 - 2.8e-09 36.6 11.0 0.00033 20.7 3.7 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE41077.1 - 2.1e-06 27.6 4.7 0.0029 17.6 0.6 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 EFE41077.1 - 8.3e-06 25.8 3.8 8.3e-06 25.8 2.6 4.0 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 EFE41077.1 - 0.00043 20.0 6.6 0.0036 17.1 0.4 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.2 EFE41077.1 - 0.002 18.2 11.0 0.0041 17.2 0.3 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EFE41077.1 - 0.35 11.0 4.2 8.1 6.6 0.2 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-trcl PF13451.1 EFE41077.1 - 0.96 9.1 4.1 0.63 9.7 0.5 2.2 2 0 0 2 2 2 0 Probable zinc-binding domain zf-LYAR PF08790.6 EFE41077.1 - 1 9.1 3.2 2.5 7.8 0.2 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger PITH PF06201.8 EFE41078.1 - 1.1e-36 125.9 0.0 2e-36 125.0 0.0 1.4 1 1 0 1 1 1 1 PITH domain zf-CSL PF05207.8 EFE41079.1 - 2.1e-16 59.1 0.8 3.5e-16 58.4 0.6 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.26 EFE41079.1 - 1.4e-15 56.7 0.1 2.5e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain ERG2_Sigma1R PF04622.7 EFE41080.1 - 5.9e-49 166.2 0.7 7e-49 165.9 0.5 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein peroxidase PF00141.18 EFE41081.1 - 5.1e-51 173.3 0.0 7.9e-51 172.7 0.0 1.2 1 0 0 1 1 1 1 Peroxidase DUF4366 PF14283.1 EFE41081.1 - 0.015 14.6 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) PolyA_pol_arg_C PF12626.2 EFE41082.1 - 0.056 13.0 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 Polymerase A arginine-rich C-terminus IstB_IS21 PF01695.12 EFE41082.1 - 0.15 11.4 0.1 0.24 10.7 0.0 1.3 1 1 0 1 1 1 0 IstB-like ATP binding protein Mid2 PF04478.7 EFE41084.1 - 0.00013 21.4 0.1 0.00024 20.5 0.1 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor DUF4366 PF14283.1 EFE41084.1 - 0.0032 16.9 0.5 0.031 13.6 0.3 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4366) SKG6 PF08693.5 EFE41084.1 - 0.03 13.6 0.9 0.093 12.0 0.7 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF3445 PF11927.3 EFE41085.1 - 1.6e-81 273.4 0.0 1.9e-81 273.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) DUF221 PF02714.10 EFE41087.1 - 7.6e-92 307.6 20.8 1.1e-91 307.1 14.4 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFE41087.1 - 4.5e-40 136.7 0.6 4.5e-40 136.7 0.4 2.2 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 EFE41087.1 - 6.6e-17 61.8 0.0 1.4e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) SDA1 PF05285.7 EFE41088.1 - 0.051 12.8 30.1 0.066 12.4 20.8 1.1 1 0 0 1 1 1 0 SDA1 Sporozoite_P67 PF05642.6 EFE41088.1 - 0.3 8.8 9.8 0.4 8.4 6.8 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2956 PF11169.3 EFE41088.1 - 0.71 9.8 13.9 0.33 10.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) CENP-T PF15511.1 EFE41088.1 - 0.99 8.5 16.5 1.1 8.3 11.4 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Pinin_SDK_memA PF04696.8 EFE41088.1 - 2.6 7.6 20.2 0.025 14.1 5.2 2.1 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region ARHGEF5_35 PF15441.1 EFE41088.1 - 7.3 5.2 27.2 8.9 4.9 18.8 1.1 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 zf-C2H2_4 PF13894.1 EFE41090.1 - 0.0012 19.0 20.7 0.071 13.4 0.0 4.9 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE41090.1 - 0.0012 19.0 22.5 0.38 11.2 0.0 5.1 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EFE41090.1 - 0.03 14.2 0.5 2.3 8.2 0.4 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger RPN7 PF10602.4 EFE41091.1 - 3.2e-54 182.9 0.1 5.4e-54 182.2 0.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 EFE41091.1 - 3.1e-10 40.2 0.1 1.1e-09 38.5 0.0 2.0 1 0 0 1 1 1 1 PCI domain LEDGF PF11467.3 EFE41091.1 - 0.057 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) Phage_sheath_1 PF04984.9 EFE41091.1 - 0.11 10.9 0.0 0.22 9.9 0.0 1.4 1 0 0 1 1 1 0 Phage tail sheath protein DSBA PF01323.15 EFE41092.1 - 8.6e-11 41.7 0.0 1.1e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.20 EFE41093.1 - 1.7e-18 67.1 0.0 2.2e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE41093.1 - 8.7e-07 28.9 0.0 1.1e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE41093.1 - 2e-06 27.5 0.0 3e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 EFE41093.1 - 0.005 16.6 0.1 0.1 12.3 0.1 2.4 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 EFE41093.1 - 0.011 15.7 0.3 0.024 14.6 0.2 1.8 1 1 0 1 1 1 0 NADH(P)-binding THF_DHG_CYH_C PF02882.14 EFE41093.1 - 0.069 12.2 0.0 0.14 11.1 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain LtrA PF06772.6 EFE41094.1 - 6.8e-09 35.0 4.4 6.8e-09 35.0 3.0 2.6 2 1 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) NTR2 PF15458.1 EFE41095.1 - 5.5e-75 251.8 22.8 5.5e-75 251.8 15.8 1.4 2 0 0 2 2 2 1 Nineteen complex-related protein 2 Nup54 PF13874.1 EFE41095.1 - 0.9 9.2 8.7 0.088 12.4 1.4 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Spc7 PF08317.6 EFE41095.1 - 7.4 5.1 13.2 0.051 12.2 2.2 2.2 2 1 0 2 2 2 0 Spc7 kinetochore protein Peptidase_M1 PF01433.15 EFE41096.1 - 2.3e-07 30.2 0.0 0.16 11.0 0.0 3.6 4 0 0 4 4 4 3 Peptidase family M1 Apo-CII PF05355.6 EFE41096.1 - 0.038 13.8 0.0 0.093 12.6 0.0 1.6 1 0 0 1 1 1 0 Apolipoprotein C-II ATP-synt_8 PF00895.15 EFE41097.1 - 0.088 13.0 0.2 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 ATP synthase protein 8 PALP PF00291.20 EFE41099.1 - 2.1e-26 92.8 0.1 2.6e-26 92.5 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme LYTB PF02401.13 EFE41099.1 - 0.074 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 LytB protein DUF212 PF02681.9 EFE41099.1 - 0.09 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Divergent PAP2 family DUF4187 PF13821.1 EFE41100.1 - 2.1e-18 65.6 3.3 2.4e-18 65.4 1.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.18 EFE41100.1 - 3.6e-10 39.4 2.7 1.1e-08 34.7 1.8 2.6 1 1 0 1 1 1 1 G-patch domain SpoIIIAH PF12685.2 EFE41103.1 - 0.025 14.0 0.0 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein ATP_transf PF09830.4 EFE41107.1 - 1.3e-21 76.1 0.1 2.3e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.18 EFE41107.1 - 0.091 13.3 0.1 0.22 12.0 0.1 1.7 1 0 0 1 1 1 0 HIT domain GRP PF07172.6 EFE41108.1 - 0.073 13.5 0.0 0.1 13.1 0.0 1.2 1 0 0 1 1 1 0 Glycine rich protein family Ctr PF04145.10 EFE41108.1 - 0.25 11.3 1.5 0.74 9.8 1.1 1.7 1 1 0 1 1 1 0 Ctr copper transporter family DUF2873 PF11395.3 EFE41108.1 - 0.67 9.5 6.2 1 8.9 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2873) ABC_tran PF00005.22 EFE41109.1 - 4.8e-46 156.4 0.7 2e-22 79.9 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_tran_2 PF12848.2 EFE41109.1 - 1.8e-21 75.7 7.2 1.8e-21 75.7 5.0 3.9 5 0 0 5 5 4 1 ABC transporter AAA_21 PF13304.1 EFE41109.1 - 4.2e-15 56.4 2.9 0.0032 17.4 0.0 4.9 6 0 0 6 6 5 3 AAA domain SMC_N PF02463.14 EFE41109.1 - 6.7e-11 41.8 0.2 0.011 15.0 0.0 4.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EFE41109.1 - 2.5e-08 34.7 0.6 0.011 16.4 0.0 3.3 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.18 EFE41109.1 - 2.8e-06 27.2 0.1 0.087 12.7 0.0 3.2 3 1 0 3 3 3 2 50S ribosome-binding GTPase DUF258 PF03193.11 EFE41109.1 - 8.3e-06 25.0 0.1 0.068 12.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 EFE41109.1 - 8.5e-06 25.8 1.0 0.0089 16.0 0.1 2.8 3 0 0 3 3 3 2 AAA ATPase domain Miro PF08477.8 EFE41109.1 - 2.1e-05 25.0 0.3 0.08 13.4 0.0 3.1 3 0 0 3 3 2 2 Miro-like protein AAA_29 PF13555.1 EFE41109.1 - 2.4e-05 23.7 0.1 0.23 11.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 EFE41109.1 - 7.2e-05 22.9 0.1 0.36 10.9 0.1 3.0 2 1 0 2 2 2 2 AAA domain MobB PF03205.9 EFE41109.1 - 0.0002 21.0 0.1 0.76 9.4 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.1 EFE41109.1 - 0.00033 19.8 10.1 1.1 8.2 0.0 5.2 4 2 1 5 5 5 2 AAA ATPase domain AAA_33 PF13671.1 EFE41109.1 - 0.00071 19.4 3.9 0.6 9.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.1 EFE41109.1 - 0.00085 19.3 3.0 0.4 10.6 0.0 3.0 3 0 0 3 3 2 2 AAA domain NACHT PF05729.7 EFE41109.1 - 0.0017 18.0 0.2 1.2 8.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain Dynamin_N PF00350.18 EFE41109.1 - 0.0019 18.0 5.9 0.78 9.5 0.0 4.0 4 0 0 4 4 3 1 Dynamin family AAA PF00004.24 EFE41109.1 - 0.0031 17.7 0.1 1.1 9.4 0.1 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 EFE41109.1 - 0.0032 16.9 0.2 3.7 6.8 0.0 3.3 3 0 0 3 3 3 1 AAA-like domain SbcCD_C PF13558.1 EFE41109.1 - 0.0066 16.3 0.3 3.5 7.6 0.1 3.6 3 1 0 3 3 2 1 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.17 EFE41109.1 - 0.011 15.9 0.1 5.8 7.1 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Peripla_BP_3 PF13377.1 EFE41109.1 - 0.011 15.7 0.0 5.9 6.8 0.0 2.7 2 0 0 2 2 2 0 Periplasmic binding protein-like domain ArgK PF03308.11 EFE41109.1 - 0.019 13.7 4.0 1.3 7.7 0.0 2.9 3 0 0 3 3 3 0 ArgK protein AAA_14 PF13173.1 EFE41109.1 - 0.023 14.5 0.0 8 6.3 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EFE41109.1 - 0.026 14.8 0.0 0.026 14.8 0.0 5.0 5 1 0 5 5 4 0 AAA domain AAA_18 PF13238.1 EFE41109.1 - 0.048 13.9 0.1 0.29 11.4 0.0 4.1 6 0 0 6 6 3 0 AAA domain cobW PF02492.14 EFE41109.1 - 0.049 13.0 0.5 3.3 7.1 0.3 2.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 EFE41109.1 - 0.052 13.2 1.0 3.2 7.4 0.0 3.0 3 0 0 3 3 2 0 NTPase PduV-EutP PF10662.4 EFE41109.1 - 0.066 12.6 0.1 12 5.3 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Guanylate_kin PF00625.16 EFE41110.1 - 2.1e-49 167.4 0.0 2.5e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase MFS_1 PF07690.11 EFE41111.1 - 2.6e-40 138.2 39.9 3.2e-40 137.9 27.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE41112.1 - 3.6e-74 249.9 25.5 8.6e-60 202.5 6.0 2.7 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE41112.1 - 9.4e-14 50.8 20.9 2e-08 33.3 1.3 3.3 1 1 2 3 3 3 2 Major Facilitator Superfamily ImpA-rel_N PF06812.7 EFE41112.1 - 0.01 15.5 0.2 0.035 13.8 0.1 1.9 1 0 0 1 1 1 0 ImpA-related N-terminal LacY_symp PF01306.14 EFE41112.1 - 0.04 12.4 4.7 0.41 9.1 0.4 2.2 2 0 0 2 2 2 0 LacY proton/sugar symporter RELT PF12606.3 EFE41112.1 - 0.13 11.4 0.9 0.4 9.8 0.6 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 DUF2393 PF09624.5 EFE41112.1 - 0.18 11.3 0.1 0.18 11.3 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) SKG6 PF08693.5 EFE41113.1 - 0.0026 17.0 0.8 0.0046 16.2 0.5 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain YjeF_N PF03853.10 EFE41114.1 - 1.7e-33 115.6 0.1 2.5e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 EFE41114.1 - 1.3e-08 35.2 0.6 1.3e-08 35.2 0.4 2.5 3 0 0 3 3 3 1 FDF domain Pkinase PF00069.20 EFE41115.1 - 2.8e-19 69.2 0.1 7e-17 61.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41115.1 - 7.7e-10 38.2 0.0 2.2e-07 30.2 0.0 3.1 3 0 0 3 3 3 1 Protein tyrosine kinase RIO1 PF01163.17 EFE41115.1 - 2.9e-06 26.7 0.1 5.1e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pro_isomerase PF00160.16 EFE41116.1 - 9.6e-39 133.0 0.0 1.7e-38 132.2 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.7 EFE41116.1 - 4.9e-06 25.9 0.3 2.1e-05 23.8 0.0 2.1 2 1 0 2 2 2 1 Rtf2 RING-finger U-box PF04564.10 EFE41116.1 - 0.0018 18.2 0.0 0.0081 16.0 0.0 2.0 1 1 0 1 1 1 1 U-box domain PIF1 PF05970.9 EFE41118.1 - 6.1e-64 216.2 0.1 9.3e-64 215.6 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 EFE41118.1 - 2.5e-18 66.3 0.0 4.9e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFE41118.1 - 1e-09 38.6 0.0 2.8e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 EFE41118.1 - 3.5e-05 23.8 0.1 0.00055 20.0 0.1 2.6 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 EFE41118.1 - 8e-05 20.6 0.1 0.00048 18.0 0.0 2.0 2 0 0 2 2 2 1 Helicase AAA PF00004.24 EFE41118.1 - 0.00021 21.4 0.4 0.00062 19.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 EFE41118.1 - 0.00023 20.7 0.2 0.076 12.5 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 EFE41118.1 - 0.00039 20.1 0.9 0.0012 18.5 0.1 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 EFE41118.1 - 0.0019 18.1 0.2 0.0082 16.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFE41118.1 - 0.0036 17.3 0.1 0.06 13.3 0.0 2.7 1 1 0 2 2 2 1 AAA ATPase domain PhoH PF02562.11 EFE41118.1 - 0.01 15.0 0.0 0.028 13.6 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein NB-ARC PF00931.17 EFE41118.1 - 0.016 14.0 0.4 0.029 13.2 0.3 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF2075 PF09848.4 EFE41118.1 - 0.018 14.0 0.1 0.018 14.0 0.0 2.3 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.9 EFE41118.1 - 0.018 14.7 0.2 0.077 12.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SE PF00437.15 EFE41118.1 - 0.027 13.3 0.0 0.059 12.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.17 EFE41118.1 - 0.072 13.2 0.0 0.28 11.3 0.0 2.2 1 1 0 1 1 1 0 RNA helicase Isy1 PF06246.7 EFE41118.1 - 0.075 12.4 0.1 0.075 12.4 0.1 2.1 2 0 0 2 2 2 0 Isy1-like splicing family TrwB_AAD_bind PF10412.4 EFE41118.1 - 0.11 11.0 1.4 0.16 10.5 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.2 EFE41118.1 - 0.12 11.4 0.0 0.27 10.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region D3 ABC_tran PF00005.22 EFE41118.1 - 0.32 11.3 2.7 0.47 10.7 0.1 2.6 2 1 1 3 3 3 0 ABC transporter Arch_ATPase PF01637.13 EFE41118.1 - 0.54 9.9 4.5 0.17 11.5 0.5 2.0 2 1 0 2 2 1 0 Archaeal ATPase PTCB-BRCT PF12738.2 EFE41119.1 - 2.6e-30 104.0 1.7 8.1e-15 54.4 0.2 3.6 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.21 EFE41119.1 - 1e-18 67.2 3.7 3.8e-08 33.3 0.1 4.6 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain Dynamin_N PF00350.18 EFE41120.1 - 2.3e-17 63.3 1.1 1.8e-16 60.4 0.1 2.8 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 EFE41120.1 - 2.7e-10 40.2 0.1 1.8e-08 34.3 0.0 3.5 2 2 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFE41120.1 - 2.6e-07 30.2 0.8 3.2e-06 26.7 0.1 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 EFE41120.1 - 0.011 16.1 0.1 0.69 10.4 0.1 2.8 1 1 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 EFE41120.1 - 0.039 13.4 0.0 0.089 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFE41120.1 - 0.051 13.8 0.1 0.4 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.13 EFE41120.1 - 0.06 12.6 0.3 36 3.5 0.0 3.9 5 0 0 5 5 5 0 Ferrous iron transport protein B Glypican PF01153.14 EFE41120.1 - 0.061 11.9 0.0 0.11 11.0 0.0 1.4 1 0 0 1 1 1 0 Glypican BrkDBD PF09607.5 EFE41123.1 - 0.057 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain Lon_C PF05362.8 EFE41124.1 - 4.2e-63 212.3 0.0 7.7e-63 211.5 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 EFE41124.1 - 5.6e-40 137.2 0.1 1.4e-39 135.9 0.1 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain AAA PF00004.24 EFE41124.1 - 5.7e-22 78.3 0.0 1.5e-21 76.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFE41124.1 - 6.5e-07 29.1 0.0 1.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.1 EFE41124.1 - 2.4e-06 27.0 0.0 5.5e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.9 EFE41124.1 - 3.3e-06 27.1 0.0 9e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EFE41124.1 - 1.6e-05 25.0 0.1 0.00024 21.2 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.6 EFE41124.1 - 2.3e-05 23.2 0.1 6.8e-05 21.7 0.0 1.7 2 0 0 2 2 2 1 PrkA AAA domain AAA_16 PF13191.1 EFE41124.1 - 4.2e-05 23.6 0.7 0.0008 19.4 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 EFE41124.1 - 5.1e-05 24.0 0.0 0.00028 21.7 0.0 2.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFE41124.1 - 8.6e-05 21.6 0.0 0.0011 18.0 0.0 2.7 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 EFE41124.1 - 0.0028 17.9 2.0 0.031 14.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EFE41124.1 - 0.01 15.7 0.0 0.026 14.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain SKI PF01202.17 EFE41124.1 - 0.02 14.7 0.8 0.13 12.1 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase NTPase_1 PF03266.10 EFE41124.1 - 0.028 14.1 0.2 0.94 9.1 0.0 3.1 2 1 1 3 3 3 0 NTPase MobB PF03205.9 EFE41124.1 - 0.039 13.6 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 EFE41124.1 - 0.042 13.0 0.0 0.094 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 IstB_IS21 PF01695.12 EFE41124.1 - 0.048 13.0 0.0 0.096 12.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATP-synt_ab PF00006.20 EFE41124.1 - 0.056 12.9 0.1 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.1 EFE41124.1 - 0.066 12.6 0.0 0.18 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFE41124.1 - 0.085 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.1 EFE41124.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EFE41124.1 - 1.6 9.0 5.2 0.8 9.9 0.0 2.8 3 0 0 3 3 3 0 ABC transporter CTDII PF01556.13 EFE41125.1 - 2.8e-28 97.6 2.1 3.2e-21 75.0 0.1 3.4 3 1 1 4 4 4 2 DnaJ C terminal domain DnaJ PF00226.26 EFE41125.1 - 9.7e-22 76.4 0.4 2.6e-21 75.1 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 EFE41125.1 - 7.5e-10 38.7 21.1 7.5e-10 38.7 14.7 2.2 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.14 EFE41125.1 - 0.05 13.3 7.7 0.11 12.1 0.6 2.4 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family BRO1 PF03097.13 EFE41127.1 - 2.7e-130 434.5 0.3 2.7e-130 434.5 0.2 2.0 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 EFE41127.1 - 3.9e-96 321.5 15.3 6.3e-96 320.8 10.6 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV SAP30_Sin3_bdg PF13867.1 EFE41128.1 - 1.9e-15 56.4 0.2 7.5e-15 54.5 0.1 1.9 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF4466 PF14725.1 EFE41128.1 - 0.011 15.0 0.1 0.024 13.9 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4466) F-box PF00646.28 EFE41129.1 - 4e-08 32.6 0.2 1.4e-06 27.7 0.2 2.5 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EFE41129.1 - 0.00066 19.3 0.4 0.028 14.1 0.1 2.6 2 0 0 2 2 2 1 F-box-like Apt1 PF10351.4 EFE41131.1 - 1.3 7.7 4.7 1.5 7.5 3.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-C2H2 PF00096.21 EFE41132.1 - 1.7e-06 28.0 12.3 0.0088 16.3 2.8 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFE41132.1 - 3.1e-06 27.1 8.7 8.4e-06 25.8 1.3 3.9 3 1 0 3 3 3 2 Zinc-finger double domain Zip PF02535.17 EFE41132.1 - 0.0015 17.5 6.9 0.0015 17.5 4.8 2.1 2 0 0 2 2 2 1 ZIP Zinc transporter RED_N PF07808.8 EFE41133.1 - 3.8e-10 39.3 1.3 1.1e-09 37.9 0.9 1.8 1 0 0 1 1 1 1 RED-like protein N-terminal region TRAUB PF08164.7 EFE41133.1 - 0.58 10.2 3.7 0.44 10.6 0.3 2.5 2 0 0 2 2 2 0 Apoptosis-antagonizing transcription factor, C-terminal Glyco_hydro_cc PF11790.3 EFE41134.1 - 1.4e-61 207.9 0.4 1.6e-61 207.7 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Imm1 PF14430.1 EFE41134.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Immunity protein Imm1 Peptidase_S8 PF00082.17 EFE41135.1 - 2.6e-53 181.0 1.9 3.7e-53 180.5 1.3 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 EFE41135.1 - 9.1e-27 92.6 1.1 1.7e-26 91.7 0.8 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF1932 PF09130.6 EFE41136.1 - 0.15 11.8 0.2 18 5.1 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1932) DUF3328 PF11807.3 EFE41137.1 - 5.1e-28 98.2 4.0 6.5e-28 97.8 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Methyltransf_2 PF00891.13 EFE41138.1 - 4.1e-44 150.6 0.2 5.1e-44 150.2 0.1 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 EFE41138.1 - 1.4e-06 28.0 0.0 2.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE41138.1 - 2.4e-06 28.0 0.1 3.1e-05 24.5 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain CheR PF01739.13 EFE41138.1 - 0.007 15.6 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.9 EFE41138.1 - 0.057 12.7 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.7 EFE41138.1 - 0.083 13.3 0.2 0.69 10.4 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Myb_DNA-binding PF00249.26 EFE41139.1 - 0.0014 18.6 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE41139.1 - 0.0095 16.0 0.1 0.016 15.3 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFE41140.1 - 5.8e-16 58.2 0.3 1.2e-10 41.2 0.2 2.4 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE41140.1 - 7.8e-15 54.7 0.2 9.7e-15 54.4 0.1 1.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Rap1_C PF11626.3 EFE41140.1 - 0.0066 16.3 0.4 1.7 8.5 0.0 2.1 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_4 PF13837.1 EFE41140.1 - 0.007 16.4 0.5 0.035 14.2 0.2 2.0 2 1 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 EFE41140.1 - 0.024 14.5 0.5 2.5 8.0 0.4 2.8 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain FAD_binding_4 PF01565.18 EFE41141.1 - 4.8e-25 87.6 0.1 8.5e-25 86.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain PsbT PF01405.12 EFE41141.1 - 0.018 14.5 0.1 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre T protein adh_short PF00106.20 EFE41142.1 - 8.9e-26 90.7 1.3 9.6e-26 90.6 0.4 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE41142.1 - 1.7e-14 54.2 0.0 2.4e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE41142.1 - 3.8e-10 39.7 0.1 6.6e-10 38.9 0.1 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFE41142.1 - 5.4e-07 29.7 0.1 2e-06 27.9 0.0 1.9 1 1 1 2 2 2 1 NADH(P)-binding DUF1776 PF08643.5 EFE41142.1 - 1.3e-05 24.5 0.0 2.1e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.3 EFE41142.1 - 0.0029 17.3 0.1 0.0073 16.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase KdpC PF02669.10 EFE41142.1 - 0.011 15.4 0.0 0.15 11.7 0.0 2.1 2 0 0 2 2 2 0 K+-transporting ATPase, c chain Saccharop_dh PF03435.13 EFE41142.1 - 0.03 13.3 0.1 0.036 13.0 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NmrA PF05368.8 EFE41142.1 - 0.052 12.7 0.1 2.6 7.2 0.1 2.2 2 0 0 2 2 2 0 NmrA-like family Epimerase PF01370.16 EFE41142.1 - 0.054 12.9 0.1 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AA_permease PF00324.16 EFE41143.1 - 4.4e-114 381.4 37.7 5.2e-114 381.2 26.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE41143.1 - 1.8e-29 102.5 42.0 2.6e-29 102.0 29.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3675 PF12428.3 EFE41143.1 - 1.8 8.8 4.7 5.5 7.2 3.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) KGG PF10685.4 EFE41144.1 - 1.2e-26 92.0 22.3 1.4e-11 43.9 2.0 3.2 3 0 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif Aminotran_5 PF00266.14 EFE41145.1 - 1.7e-17 63.2 0.0 2.1e-16 59.6 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V UNC-93 PF05978.11 EFE41146.1 - 1.5e-06 27.7 2.1 5.7e-06 25.9 1.4 1.9 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 WD40 PF00400.27 EFE41147.1 - 2.1e-30 103.4 6.8 4.2e-08 32.7 0.1 6.1 5 2 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.3 EFE41147.1 - 1.7e-05 23.2 0.0 0.008 14.3 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Exo_endo_phos PF03372.18 EFE41148.1 - 1.1e-15 58.2 0.2 1.6e-15 57.7 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Thi4 PF01946.12 EFE41149.1 - 1.3e-99 331.9 0.0 1.6e-99 331.6 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 EFE41149.1 - 1.8e-07 30.3 0.1 2.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFE41149.1 - 2.7e-05 23.2 0.2 4.9e-05 22.4 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFE41149.1 - 3e-05 23.9 0.1 0.00015 21.6 0.1 2.2 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFE41149.1 - 0.0012 18.5 0.1 0.0042 16.8 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFE41149.1 - 0.0047 16.8 0.1 0.0088 15.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE41149.1 - 0.0077 16.3 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFE41149.1 - 0.05 12.4 0.2 0.14 10.9 0.2 1.7 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.14 EFE41149.1 - 0.062 12.3 0.1 0.093 11.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.9 EFE41149.1 - 0.065 11.8 0.2 0.09 11.3 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Ppx-GppA PF02541.11 EFE41151.1 - 1e-40 139.7 0.0 1.2e-39 136.2 0.0 2.0 1 1 0 1 1 1 1 Ppx/GppA phosphatase family LINES_C PF14695.1 EFE41151.1 - 0.078 12.2 0.0 0.18 11.0 0.0 1.6 1 0 0 1 1 1 0 Lines C-terminus Proteasome PF00227.21 EFE41152.1 - 5e-48 162.8 0.1 6e-48 162.6 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF554 PF04474.7 EFE41152.1 - 0.086 11.9 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF554) SWI-SNF_Ssr4 PF08549.5 EFE41153.1 - 1.2e-157 526.1 12.2 1.3e-157 526.0 8.5 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) RNA_pol_Rpb2_6 PF00562.23 EFE41154.1 - 3.3e-116 388.2 0.0 4.3e-116 387.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EFE41154.1 - 4e-33 114.0 0.0 5.6e-33 113.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 EFE41154.1 - 2.5e-27 95.5 0.0 4.4e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.7 EFE41154.1 - 3.4e-24 84.5 0.1 9.2e-24 83.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_3 PF04565.11 EFE41154.1 - 4.9e-24 83.8 0.0 1.1e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.15 EFE41154.1 - 6.4e-15 55.1 0.0 4.5e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 EFE41154.1 - 0.00046 20.0 0.0 0.0012 18.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 KR PF08659.5 EFE41155.1 - 7.7e-56 188.6 0.0 1.9e-55 187.3 0.1 1.6 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 EFE41155.1 - 4.4e-44 150.3 0.1 1e-43 149.1 0.1 1.7 1 0 0 1 1 1 1 short chain dehydrogenase ketoacyl-synt PF00109.21 EFE41155.1 - 1.7e-35 122.7 0.0 2.8e-35 122.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ADH_zinc_N PF00107.21 EFE41155.1 - 1.5e-15 56.9 0.0 2.8e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFE41155.1 - 7.6e-10 39.7 0.0 2.5e-09 38.0 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE41155.1 - 2e-06 27.4 0.1 4.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.20 EFE41155.1 - 0.0031 17.7 0.1 0.012 15.8 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site MIP-T3 PF10243.4 EFE41156.1 - 0.00012 20.7 12.3 0.00014 20.5 8.5 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 DUF2413 PF10310.4 EFE41156.1 - 0.026 13.3 7.9 0.04 12.7 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) DUF2663 PF10864.3 EFE41156.1 - 0.22 11.7 0.0 0.22 11.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) MCPVI PF02993.9 EFE41157.1 - 9.8 6.2 7.7 11 6.1 5.4 1.0 1 0 0 1 1 1 0 Minor capsid protein VI Corona_S2 PF01601.11 EFE41158.1 - 0.21 9.6 16.1 0.31 9.0 11.1 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Podoplanin PF05808.6 EFE41158.1 - 0.55 9.7 4.4 3.2 7.2 0.8 2.5 2 0 0 2 2 2 0 Podoplanin MFS_1 PF07690.11 EFE41159.1 - 7.7e-21 74.1 50.2 7.7e-21 74.1 34.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE41159.1 - 1.3e-10 40.4 42.5 7.3e-05 21.5 3.5 4.2 3 1 1 4 4 4 4 Sugar (and other) transporter CwfJ_C_1 PF04677.10 EFE41161.1 - 1.7e-25 89.0 0.0 3.7e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 EFE41161.1 - 1.2e-24 86.5 0.1 2.7e-24 85.5 0.1 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Toxin_38 PF14866.1 EFE41161.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Potassium channel toxin DRIM PF07539.7 EFE41162.1 - 1.3e-41 141.2 0.0 9e-41 138.5 0.0 2.6 2 0 0 2 2 2 1 Down-regulated in metastasis HEAT PF02985.17 EFE41162.1 - 0.0017 18.2 6.6 1.3 9.3 0.0 6.7 8 0 0 8 8 8 1 HEAT repeat zf-DNL PF05180.7 EFE41163.1 - 4.8e-27 93.4 0.2 4.8e-27 93.4 0.2 1.7 2 0 0 2 2 2 1 DNL zinc finger zf-CSL PF05207.8 EFE41163.1 - 0.0015 18.0 0.1 0.0027 17.1 0.1 1.4 1 0 0 1 1 1 1 CSL zinc finger TFIIS_C PF01096.13 EFE41163.1 - 0.019 14.5 1.4 2.1 8.0 0.2 2.7 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Elf1 PF05129.8 EFE41163.1 - 0.11 12.2 0.3 0.25 11.0 0.2 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Zn_Tnp_IS1595 PF12760.2 EFE41163.1 - 3.6 7.4 6.1 7.3 6.4 0.5 2.4 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Cullin PF00888.17 EFE41164.1 - 3.2e-128 428.8 6.4 3.2e-128 428.8 4.4 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 EFE41164.1 - 2.4e-28 97.7 0.7 1e-27 95.7 0.3 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF1737 PF08410.5 EFE41164.1 - 0.021 14.5 0.1 0.06 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) Sld5 PF05916.6 EFE41165.1 - 3.4e-06 27.3 0.2 4.9e-06 26.7 0.2 1.2 1 0 0 1 1 1 1 GINS complex protein Rhodanese PF00581.15 EFE41166.1 - 1.8e-13 50.8 0.0 3.7e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain SART-1 PF03343.8 EFE41168.1 - 0.69 8.1 13.2 0.89 7.8 9.2 1.1 1 0 0 1 1 1 0 SART-1 family Iso_dh PF00180.15 EFE41170.1 - 1.1e-82 277.7 0.0 1.3e-82 277.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DNA_pol_phi PF04931.8 EFE41171.1 - 1.2e-68 231.7 18.0 1.3e-61 208.4 12.5 2.2 2 0 0 2 2 2 2 DNA polymerase phi TPT PF03151.11 EFE41172.1 - 1.4e-28 99.5 13.4 1.4e-28 99.5 9.3 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 EFE41172.1 - 0.00059 18.8 24.3 0.00059 18.8 16.8 1.8 1 1 1 2 2 2 1 UAA transporter family EamA PF00892.15 EFE41172.1 - 0.0037 17.2 37.5 0.0065 16.5 9.8 3.0 2 2 0 2 2 2 2 EamA-like transporter family UcrQ PF02939.11 EFE41172.1 - 0.094 12.5 0.0 0.32 10.8 0.0 1.9 2 0 0 2 2 2 0 UcrQ family AD PF09793.4 EFE41173.1 - 6.2e-24 83.6 0.0 1.6e-23 82.3 0.0 1.7 2 0 0 2 2 2 1 Anticodon-binding domain Menin PF05053.8 EFE41173.1 - 0.33 9.0 2.6 0.46 8.5 1.8 1.2 1 0 0 1 1 1 0 Menin RRM_1 PF00076.17 EFE41174.1 - 6.1e-18 64.2 0.0 9.6e-18 63.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41174.1 - 1.8e-10 40.6 0.0 3.3e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41174.1 - 0.0011 18.8 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.4 EFE41174.1 - 0.015 13.5 4.0 0.017 13.4 2.8 1.1 1 0 0 1 1 1 0 Transmembrane protein OB_RNB PF08206.6 EFE41174.1 - 0.15 11.5 0.2 0.3 10.6 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain Conotoxin PF02950.12 EFE41175.1 - 0.003 18.3 0.1 0.004 17.9 0.1 1.2 1 0 0 1 1 1 1 Conotoxin OSTbeta PF15048.1 EFE41175.1 - 0.024 14.7 0.3 0.031 14.3 0.2 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF3357 PF11837.3 EFE41175.1 - 0.032 14.0 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) OAD_gamma PF04277.8 EFE41175.1 - 0.049 14.0 0.7 0.082 13.2 0.5 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain UPF0542 PF15086.1 EFE41175.1 - 0.057 13.1 2.0 0.08 12.6 1.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 EphA2_TM PF14575.1 EFE41175.1 - 0.061 13.7 0.0 0.074 13.4 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SIT PF15330.1 EFE41175.1 - 0.093 12.8 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT 6PGD PF00393.14 EFE41176.1 - 2.5e-133 443.7 0.0 3.1e-133 443.4 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 EFE41176.1 - 3.2e-51 173.3 0.0 4.6e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EFE41176.1 - 0.1 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.15 EFE41176.1 - 0.14 12.2 0.1 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Esterase_phd PF10503.4 EFE41176.1 - 0.14 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase DNA_pol3_beta PF00712.14 EFE41176.1 - 0.18 11.7 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain Peptidase_C15 PF01470.12 EFE41177.1 - 1.7e-15 57.4 0.0 2.3e-08 34.1 0.0 2.1 2 0 0 2 2 2 2 Pyroglutamyl peptidase AA_permease PF00324.16 EFE41179.1 - 8e-111 370.7 36.7 9.9e-111 370.4 25.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE41179.1 - 5.5e-28 97.6 39.1 6.7e-28 97.3 27.1 1.0 1 0 0 1 1 1 1 Amino acid permease HET PF06985.6 EFE41180.1 - 1.3e-26 93.4 0.3 5.4e-22 78.4 0.1 2.5 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.2 EFE41180.1 - 5.3e-11 42.7 0.0 2.2e-10 40.7 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE41180.1 - 4.9e-08 33.2 0.1 0.00095 19.6 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE41180.1 - 1.7e-07 31.2 0.0 3.8e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 EFE41180.1 - 6.2e-07 28.9 0.0 0.0012 18.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 EFE41180.1 - 0.003 17.6 0.0 0.12 12.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat AP_endonuc_2 PF01261.19 EFE41181.1 - 9.4e-22 77.3 0.0 1.4e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel SOBP PF15279.1 EFE41181.1 - 1.3 9.3 10.3 2.3 8.5 7.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Mad3_BUB1_I PF08311.7 EFE41182.1 - 9.5e-44 148.2 0.1 2e-43 147.1 0.1 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.20 EFE41182.1 - 3.5e-15 55.8 0.0 8.6e-14 51.3 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Mad3_BUB1_II PF08171.6 EFE41182.1 - 4.9e-05 23.1 0.0 0.00018 21.3 0.0 2.1 1 0 0 1 1 1 1 Mad3/BUB1 homology region 2 Pkinase_Tyr PF07714.12 EFE41182.1 - 0.00033 19.7 0.0 0.0013 17.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Hexokinase_2 PF03727.11 EFE41185.1 - 6e-25 87.8 0.0 4.7e-20 71.8 0.0 2.1 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.16 EFE41185.1 - 6e-23 81.2 0.0 2.5e-21 75.9 0.0 2.5 1 1 0 1 1 1 1 Hexokinase Lipoprotein_19 PF13617.1 EFE41185.1 - 0.9 9.2 3.7 0.49 10.0 0.3 2.2 3 0 0 3 3 3 0 YnbE-like lipoprotein ADH_zinc_N PF00107.21 EFE41186.1 - 1.2e-05 24.8 0.1 3.7e-05 23.2 0.1 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Fungal_trans PF04082.13 EFE41187.1 - 1e-12 47.5 1.0 1.5e-12 46.9 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE41187.1 - 1.9e-09 37.2 9.5 3.9e-09 36.2 6.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRP PF06011.7 EFE41188.1 - 1.8e-155 517.8 29.6 2.3e-155 517.5 20.5 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EFE41188.1 - 2.3e-31 108.7 0.0 3.8e-31 108.0 0.0 1.4 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.10 EFE41188.1 - 0.18 12.0 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 ML domain IncA PF04156.9 EFE41188.1 - 1.9 8.0 0.0 1.9 8.0 0.0 2.8 3 0 0 3 3 3 0 IncA protein p450 PF00067.17 EFE41189.1 - 8.5e-28 97.0 0.0 1.1e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HsbA PF12296.3 EFE41190.1 - 1.2e-15 57.4 0.0 1.7e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Hydrophobic surface binding protein A NPV_P10 PF05531.7 EFE41190.1 - 0.13 12.5 0.0 1.6 9.0 0.0 2.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF3602 PF12223.3 EFE41191.1 - 6.5e-17 61.6 1.0 1.6e-10 41.2 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) GTP1_OBG PF01018.17 EFE41191.1 - 0.53 9.9 3.7 21 4.7 0.2 3.0 1 1 1 3 3 3 0 GTP1/OBG Actin PF00022.14 EFE41192.1 - 5.7e-125 416.7 0.0 7e-125 416.5 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EFE41192.1 - 0.11 11.0 0.0 5 5.6 0.0 2.6 3 0 0 3 3 3 0 MreB/Mbl protein Glyco_tran_28_C PF04101.11 EFE41193.1 - 0.00051 19.7 0.0 0.0014 18.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain MRP-S28 PF10213.4 EFE41194.1 - 1.1e-39 135.4 0.0 1.6e-39 134.8 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein DUF1772 PF08592.6 EFE41197.1 - 1.1e-23 83.4 0.4 3.3e-23 81.9 0.2 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) Pex2_Pex12 PF04757.9 EFE41198.1 - 7.5e-40 136.7 0.9 1.1e-39 136.2 0.7 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.20 EFE41198.1 - 0.014 15.0 1.7 0.033 13.8 1.2 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFE41198.1 - 0.02 14.7 5.6 0.02 14.7 3.9 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EFE41198.1 - 0.1 12.6 8.7 0.29 11.2 3.1 2.6 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFE41198.1 - 0.14 11.8 5.6 0.25 11.0 0.3 2.5 2 0 0 2 2 2 0 RING-type zinc-finger IBN_N PF03810.14 EFE41199.1 - 2.6e-11 43.2 0.0 1.3e-10 41.0 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EFE41199.1 - 0.0002 21.2 1.9 0.014 15.3 0.0 3.7 3 1 1 4 4 4 1 Exportin 1-like protein Cellulase PF00150.13 EFE41200.1 - 2.3e-14 53.2 2.1 3.8e-14 52.5 0.1 2.3 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) GST_N_3 PF13417.1 EFE41201.1 - 9.2e-17 61.0 0.0 1.9e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE41201.1 - 1.9e-14 53.4 0.0 3.5e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE41201.1 - 9.5e-08 31.8 1.1 1.8e-07 30.9 0.7 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFE41201.1 - 3.7e-05 23.8 0.0 0.0045 17.1 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE41201.1 - 0.0051 16.7 0.0 0.0094 15.9 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Peptidase_S49_N PF08496.5 EFE41203.1 - 0.47 10.2 5.5 0.45 10.2 3.8 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SR-25 PF10500.4 EFE41203.1 - 2.4 7.5 14.7 2.5 7.5 10.2 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med19 PF10278.4 EFE41203.1 - 7.2 6.2 13.5 7.3 6.2 9.4 1.0 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CAF-1_p150 PF11600.3 EFE41203.1 - 8 5.7 20.3 9.7 5.4 14.1 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal GPI-anchored PF10342.4 EFE41204.1 - 9.5e-22 77.2 0.1 9.5e-22 77.2 0.1 1.9 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.1 EFE41204.1 - 0.032 13.6 0.0 0.071 12.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Glyco_transf_90 PF05686.7 EFE41205.1 - 1e-37 129.7 4.6 2.8e-37 128.3 3.2 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 EFE41205.1 - 0.0041 17.3 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF16 PF01519.11 EFE41206.1 - 0.0045 17.1 5.5 0.01 16.0 3.8 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF16 DUF641 PF04859.7 EFE41206.1 - 0.097 12.4 5.1 0.26 11.0 3.6 1.7 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Gly_transf_sug PF04488.10 EFE41207.1 - 6e-09 36.2 2.0 7e-09 36.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif AAA_23 PF13476.1 EFE41207.1 - 0.018 15.3 7.6 0.028 14.7 5.3 1.3 1 0 0 1 1 1 0 AAA domain Caps_synth PF05704.7 EFE41207.1 - 0.039 13.1 0.0 0.039 13.1 0.0 2.0 2 0 0 2 2 1 0 Capsular polysaccharide synthesis protein Borrelia_P83 PF05262.6 EFE41207.1 - 0.057 11.6 12.9 0.065 11.4 8.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Adeno_E3_14_5 PF04834.7 EFE41207.1 - 0.075 13.4 0.2 0.2 12.1 0.2 1.7 1 0 0 1 1 1 0 Early E3 14.5 kDa protein Pox_A12 PF04651.8 EFE41207.1 - 0.19 11.8 8.7 0.46 10.5 6.1 1.6 1 0 0 1 1 1 0 Poxvirus A12 protein RR_TM4-6 PF06459.7 EFE41207.1 - 0.22 11.3 13.9 0.43 10.4 9.7 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Atg14 PF10186.4 EFE41207.1 - 2.1 7.1 11.2 2.9 6.7 7.8 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 RNase_H2-Ydr279 PF09468.5 EFE41207.1 - 6.1 5.9 13.5 9.2 5.3 9.4 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Ycf1 PF05758.7 EFE41207.1 - 8.1 4.0 13.3 10 3.7 9.2 1.1 1 0 0 1 1 1 0 Ycf1 Vfa1 PF08432.5 EFE41207.1 - 8.3 6.3 29.6 13 5.7 20.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1168 PF06658.7 EFE41208.1 - 0.091 12.2 12.0 0.11 11.9 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) SH3_1 PF00018.23 EFE41209.1 - 1.6e-09 37.0 0.1 2.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE41209.1 - 2.2e-07 30.3 0.0 4.6e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFE41209.1 - 7.5e-07 28.5 0.0 1.5e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain YhhN PF07947.9 EFE41209.1 - 0.11 11.8 8.4 0.16 11.3 5.8 1.1 1 0 0 1 1 1 0 YhhN-like protein UBA_4 PF14555.1 EFE41211.1 - 0.0013 18.2 0.3 0.0027 17.2 0.2 1.5 1 0 0 1 1 1 1 UBA-like domain SET PF00856.23 EFE41212.1 - 1.9e-12 47.7 0.0 4.2e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 SET domain AMP-binding PF00501.23 EFE41213.1 - 1.3e-68 231.3 0.0 1.6e-68 231.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE41213.1 - 1.9e-10 41.5 0.1 5.9e-10 39.9 0.1 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain BORG_CEP PF14957.1 EFE41214.1 - 0.24 12.3 5.0 0.32 11.9 3.4 1.2 1 0 0 1 1 1 0 Cdc42 effector eIF-3_zeta PF05091.7 EFE41214.1 - 0.27 9.7 1.9 0.31 9.6 1.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MIP-T3 PF10243.4 EFE41214.1 - 0.65 8.4 17.1 0.65 8.4 11.8 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RR_TM4-6 PF06459.7 EFE41214.1 - 0.97 9.2 9.8 1.2 8.9 6.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YqfQ PF14181.1 EFE41214.1 - 2.6 8.0 8.5 3.5 7.6 5.9 1.1 1 0 0 1 1 1 0 YqfQ-like protein NARP1 PF12569.3 EFE41214.1 - 6.4 5.3 7.9 7.4 5.2 5.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SR-25 PF10500.4 EFE41214.1 - 7 6.0 25.9 10 5.5 17.7 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein RR_TM4-6 PF06459.7 EFE41215.1 - 0.64 9.8 10.7 0.81 9.5 7.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.7 EFE41215.1 - 4.1 7.2 15.4 4.7 7.0 10.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family SPATIAL PF15256.1 EFE41215.1 - 4.2 7.3 10.1 5.9 6.9 7.0 1.2 1 0 0 1 1 1 0 SPATIAL DUF4604 PF15377.1 EFE41215.1 - 5.1 7.2 26.3 7.1 6.8 18.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) RNase_H2-Ydr279 PF09468.5 EFE41215.1 - 9 5.3 19.2 11 5.0 13.3 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Pkinase PF00069.20 EFE41216.1 - 4.3e-57 193.2 0.0 6.1e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41216.1 - 7.4e-26 90.7 0.0 1.7e-25 89.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE41216.1 - 0.0021 17.0 0.0 0.0037 16.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Bot1p PF12298.3 EFE41217.1 - 4.9e-20 72.1 0.2 4.9e-20 72.1 0.1 1.9 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein FAP PF07174.6 EFE41217.1 - 0.036 13.3 1.5 4.8 6.3 0.0 2.1 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) Bot1p PF12298.3 EFE41218.1 - 6.3e-26 91.3 0.2 1.3e-25 90.3 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein HTH_Tnp_ISL3 PF13542.1 EFE41218.1 - 0.062 12.4 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 FoP_duplication PF13865.1 EFE41220.1 - 4.4e-08 33.4 7.8 4.4e-08 33.4 5.4 2.3 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 WD40 PF00400.27 EFE41221.1 - 4.8e-13 48.4 0.6 5.5e-06 26.0 0.3 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Cap_synth_GfcB PF11102.3 EFE41221.1 - 0.031 13.8 0.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Group 4 capsule polysaccharide formation lipoprotein gfcB Me-amine-dh_H PF06433.6 EFE41221.1 - 0.16 10.6 0.0 1.9 7.0 0.0 2.0 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) PUL PF08324.6 EFE41222.1 - 5.6e-57 192.5 0.0 7.2e-57 192.2 0.0 1.1 1 0 0 1 1 1 1 PUL domain PFU PF09070.6 EFE41222.1 - 3.4e-43 146.3 0.1 7.6e-43 145.2 0.1 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 EFE41222.1 - 4e-38 127.9 22.4 7.6e-09 35.1 0.1 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat RRM_1 PF00076.17 EFE41224.1 - 1.2e-16 60.0 0.0 3.8e-13 48.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41224.1 - 9e-12 44.8 0.0 1.6e-07 31.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Suf PF05843.9 EFE41224.1 - 0.01 15.6 2.6 0.016 14.9 1.8 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Rxt3 PF08642.5 EFE41224.1 - 0.056 13.6 0.4 0.11 12.7 0.3 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Pex14_N PF04695.8 EFE41224.1 - 0.15 12.0 6.6 0.68 9.9 4.6 2.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RRM_5 PF13893.1 EFE41224.1 - 0.16 11.8 0.1 5.3 6.9 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FimP PF09766.4 EFE41224.1 - 2.3 7.2 8.5 3.7 6.5 5.9 1.2 1 0 0 1 1 1 0 Fms-interacting protein Toxin_49 PF15529.1 EFE41225.1 - 0.0012 18.7 1.2 0.0028 17.5 0.0 2.0 1 1 1 2 2 2 1 Putative toxin 49 CH PF00307.26 EFE41226.1 - 2.5e-24 85.3 0.0 4.5e-20 71.6 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.5 EFE41226.1 - 4.9e-21 74.4 0.7 6e-15 54.9 0.1 2.8 2 0 0 2 2 2 2 Ca2+ insensitive EF hand CAMSAP_CH PF11971.3 EFE41226.1 - 1.9e-08 33.8 0.3 7.5e-08 31.9 0.0 2.2 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_8 PF13833.1 EFE41226.1 - 0.0016 17.9 0.1 0.01 15.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 EFE41226.1 - 0.0027 17.4 0.0 0.016 15.0 0.0 2.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 EFE41226.1 - 0.015 14.5 0.1 0.16 11.3 0.0 2.6 2 0 0 2 2 2 0 EF hand Spectrin PF00435.16 EFE41226.1 - 0.015 15.5 6.1 0.71 10.1 0.0 2.8 2 1 0 2 2 2 0 Spectrin repeat DUF4646 PF15496.1 EFE41226.1 - 0.024 14.7 0.0 0.74 9.8 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4646) G-alpha PF00503.15 EFE41228.1 - 2.7e-125 418.1 6.0 1.8e-124 415.3 4.2 1.9 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EFE41228.1 - 2.8e-11 42.9 1.8 3.7e-10 39.3 0.1 2.7 2 1 0 2 2 2 1 ADP-ribosylation factor family zf-CHC2 PF01807.15 EFE41228.1 - 0.00011 21.6 0.0 0.00038 19.9 0.0 1.8 2 0 0 2 2 2 1 CHC2 zinc finger Miro PF08477.8 EFE41228.1 - 0.021 15.3 0.1 6.4 7.3 0.0 2.8 2 0 0 2 2 2 0 Miro-like protein Mog1 PF04603.7 EFE41228.1 - 0.072 13.0 0.3 0.66 9.9 0.0 2.5 3 0 0 3 3 3 0 Ran-interacting Mog1 protein GTP_EFTU PF00009.22 EFE41228.1 - 0.075 12.4 0.1 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Use1 PF09753.4 EFE41229.1 - 3.5e-09 36.4 6.3 2.4e-08 33.7 4.4 2.2 1 1 0 1 1 1 1 Membrane fusion protein Use1 GldM_N PF12081.3 EFE41229.1 - 0.065 12.7 0.2 0.14 11.6 0.2 1.5 1 0 0 1 1 1 0 GldM N-terminal domain Acetyltransf_7 PF13508.1 EFE41230.1 - 0.00011 22.3 0.0 0.00024 21.2 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE41230.1 - 0.00081 19.3 0.0 0.002 18.1 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFE41230.1 - 0.004 17.2 0.0 0.023 14.8 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain RXT2_N PF08595.6 EFE41232.1 - 0.005 16.6 5.2 0.0056 16.4 3.6 1.2 1 0 0 1 1 1 1 RXT2-like, N-terminal RNA_pol_3_Rpc31 PF11705.3 EFE41232.1 - 0.014 15.3 11.7 0.016 15.1 8.1 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.7 EFE41232.1 - 0.017 14.8 8.4 0.017 14.8 5.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BTV_NS2 PF04514.7 EFE41232.1 - 0.028 13.3 5.2 0.031 13.1 3.6 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Sporozoite_P67 PF05642.6 EFE41232.1 - 0.036 11.9 3.6 0.032 12.0 2.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.4 EFE41232.1 - 0.078 11.6 15.7 0.085 11.5 10.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3449 PF11931.3 EFE41232.1 - 0.08 12.4 4.9 0.096 12.1 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Nucleo_P87 PF07267.6 EFE41232.1 - 0.2 10.3 5.1 0.26 9.9 3.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2796 PF10986.3 EFE41232.1 - 0.24 11.3 6.9 0.27 11.2 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) CDC45 PF02724.9 EFE41232.1 - 0.52 8.2 8.8 0.61 8.0 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 EFE41232.1 - 0.75 7.6 12.9 0.79 7.5 8.9 1.0 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.9 EFE41232.1 - 0.77 9.2 6.9 0.88 9.0 4.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Rhabdo_ncap PF00945.13 EFE41232.1 - 0.87 8.1 3.5 1 7.8 2.4 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Sigma70_ner PF04546.8 EFE41232.1 - 5.1 6.6 11.4 6.9 6.2 7.9 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region UPF0560 PF10577.4 EFE41232.1 - 7.6 4.6 6.7 8.6 4.4 4.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 AMP-binding PF00501.23 EFE41233.1 - 8.3e-21 73.8 0.6 1.4e-20 73.1 0.4 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE41233.1 - 0.00013 22.8 0.0 0.00023 22.0 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF4245 PF14030.1 EFE41233.1 - 0.11 12.1 0.1 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) AMP-binding PF00501.23 EFE41234.1 - 4.2e-53 180.2 0.0 5.2e-53 179.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Nup188 PF10487.4 EFE41235.1 - 6.3e-54 183.2 1.7 5.1e-52 176.9 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 DUF465 PF04325.8 EFE41235.1 - 0.11 12.1 0.0 0.31 10.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF465) IGPS PF00218.16 EFE41236.1 - 4e-95 317.6 0.0 1.3e-94 316.0 0.0 1.8 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.17 EFE41236.1 - 1.3e-52 178.1 0.2 3.2e-49 167.1 0.0 2.3 2 0 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.23 EFE41236.1 - 9.5e-51 171.9 0.0 1.6e-50 171.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EFE41236.1 - 0.00026 20.4 0.1 0.0011 18.4 0.0 2.0 2 1 0 2 2 2 1 Peptidase C26 QRPTase_C PF01729.14 EFE41236.1 - 0.0021 17.6 0.4 0.11 12.0 0.0 2.5 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.16 EFE41236.1 - 0.0083 15.4 0.1 0.054 12.7 0.0 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein PTCB-BRCT PF12738.2 EFE41237.1 - 3.3e-05 23.6 0.0 6.4e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 EFE41237.1 - 7.6e-05 22.7 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA_12 PF13087.1 EFE41238.1 - 2.8e-58 196.6 0.0 4.6e-58 195.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain UPF1_Zn_bind PF09416.5 EFE41238.1 - 6.6e-58 194.6 0.4 1.4e-56 190.2 0.0 2.3 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_11 PF13086.1 EFE41238.1 - 3.3e-56 190.5 3.0 4.9e-56 189.9 2.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE41238.1 - 2.3e-13 49.6 0.4 6.3e-13 48.2 0.3 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EFE41238.1 - 1.2e-10 41.3 0.3 1.6e-09 37.6 0.2 2.3 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 EFE41238.1 - 2.1e-08 34.2 0.0 3.7e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 EFE41238.1 - 0.00016 21.3 0.0 0.00033 20.3 0.0 1.5 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 EFE41238.1 - 0.00039 20.0 0.1 0.99 8.8 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 EFE41238.1 - 0.0021 17.0 1.8 0.0077 15.2 0.1 2.4 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.24 EFE41238.1 - 0.014 14.8 0.3 0.033 13.6 0.2 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase UvrD-helicase PF00580.16 EFE41238.1 - 0.018 14.3 0.1 0.24 10.6 0.0 2.4 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.9 EFE41238.1 - 0.021 13.7 0.0 4.8 6.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase Ribosomal_S13_N PF08069.7 EFE41238.1 - 0.022 14.5 0.0 0.06 13.1 0.0 1.7 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain AAA_22 PF13401.1 EFE41238.1 - 0.04 14.0 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EFE41238.1 - 0.053 12.7 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein TFIIF_alpha PF05793.7 EFE41238.1 - 0.068 11.5 2.3 0.12 10.7 1.6 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SRP54 PF00448.17 EFE41238.1 - 0.089 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain T2SE PF00437.15 EFE41238.1 - 0.14 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein KaiC PF06745.8 EFE41238.1 - 0.19 10.8 0.0 0.36 9.9 0.0 1.4 1 0 0 1 1 1 0 KaiC Brix PF04427.13 EFE41239.1 - 9.4e-47 159.1 0.1 1.2e-46 158.8 0.0 1.1 1 0 0 1 1 1 1 Brix domain AhpC-TSA_2 PF13911.1 EFE41240.1 - 1.4e-11 44.3 0.0 2.3e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.16 EFE41240.1 - 0.024 14.2 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family PI-PLC-X PF00388.14 EFE41241.1 - 7.6e-57 190.8 0.0 1.8e-56 189.6 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EFE41241.1 - 1.5e-40 137.8 0.1 3.2e-40 136.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 EFE41241.1 - 5e-06 26.2 0.0 1.2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.6 EFE41241.1 - 1e-05 25.4 0.1 3.3e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_8 PF13833.1 EFE41241.1 - 0.0014 18.2 0.0 0.0029 17.1 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 EFE41241.1 - 0.0062 16.6 0.0 0.13 12.3 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 EFE41241.1 - 0.023 14.0 0.0 0.057 12.7 0.0 1.7 1 0 0 1 1 1 0 EF hand GDPD PF03009.12 EFE41241.1 - 0.042 13.3 0.0 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family DUF3938 PF13074.1 EFE41242.1 - 0.024 14.4 0.1 0.049 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3938) Chitin_bind_3 PF03067.10 EFE41242.1 - 0.087 13.0 0.0 0.5 10.6 0.0 1.9 1 1 0 1 1 1 0 Chitin binding domain Mo-co_dimer PF03404.11 EFE41244.1 - 6.7e-55 184.2 0.3 1.3e-54 183.3 0.2 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.14 EFE41244.1 - 5.3e-33 113.8 0.0 9.8e-33 112.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Cyt-b5 PF00173.23 EFE41244.1 - 3.1e-23 81.3 0.0 6.8e-23 80.2 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.16 EFE41244.1 - 3.1e-23 82.4 0.0 7.4e-23 81.2 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFE41244.1 - 3.4e-15 55.9 0.0 5.9e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EFE41244.1 - 7.7e-05 22.6 0.1 0.0087 15.9 0.0 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Sec5 PF15469.1 EFE41245.1 - 9.1e-34 116.7 0.0 4.2e-33 114.6 0.0 2.1 2 0 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.6 EFE41245.1 - 4.3e-06 26.4 0.5 1.5e-05 24.7 0.4 2.0 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.6 EFE41245.1 - 0.016 15.0 0.1 0.067 13.0 0.1 2.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Iso_dh PF00180.15 EFE41246.1 - 1.8e-100 336.2 0.0 2.3e-100 335.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Spc97_Spc98 PF04130.8 EFE41247.1 - 9e-59 199.2 0.0 1.1e-58 198.8 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family rRNA_processing PF08524.6 EFE41248.1 - 0.007 16.1 10.2 0.007 16.1 7.1 2.6 1 1 1 2 2 2 1 rRNA processing Glypican PF01153.14 EFE41248.1 - 3.1 6.3 4.5 3.9 5.9 3.1 1.3 1 1 0 1 1 1 0 Glypican DUF4210 PF13915.1 EFE41249.1 - 1.3e-27 95.8 0.1 4.2e-27 94.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.1 EFE41249.1 - 3.5e-21 74.8 0.2 7.9e-21 73.6 0.2 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis CAP_N PF01213.14 EFE41250.1 - 2.9e-82 276.4 0.0 4.7e-82 275.7 0.0 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 EFE41250.1 - 2.8e-53 179.5 1.2 3.8e-53 179.0 0.8 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.7 EFE41250.1 - 0.024 14.0 3.3 0.25 10.7 1.8 2.1 1 1 1 2 2 2 0 Tubulin binding cofactor C Ribosomal_60s PF00428.14 EFE41250.1 - 0.67 10.3 7.4 0.11 12.8 0.5 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein PfkB PF00294.19 EFE41251.1 - 6.2e-11 41.9 0.0 9.7e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase FTO_CTD PF12934.2 EFE41251.1 - 0.081 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 FTO C-terminal domain Ribonucleas_3_3 PF14622.1 EFE41252.1 - 5.5e-07 29.5 0.0 0.0062 16.4 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.20 EFE41252.1 - 7.6e-06 26.4 0.0 1.3e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.21 EFE41252.1 - 2.8e-05 24.5 0.0 5.7e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Ribonuclease III domain ATP12 PF07542.6 EFE41252.1 - 0.014 15.3 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 0 ATP12 chaperone protein BSP PF04450.7 EFE41253.1 - 1.7e-62 210.5 0.0 2e-62 210.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria CLASP_N PF12348.3 EFE41254.1 - 3e-149 494.5 2.6 8e-91 303.4 0.0 2.8 3 0 0 3 3 3 2 CLASP N terminal HEAT PF02985.17 EFE41254.1 - 1.3e-07 31.0 0.2 1.5 9.1 0.0 6.3 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.1 EFE41254.1 - 0.00034 20.8 2.5 0.016 15.4 0.0 4.8 6 1 1 7 7 7 1 HEAT repeats Cnd1 PF12717.2 EFE41254.1 - 0.079 12.8 1.0 11 5.7 0.0 3.8 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Acetyltransf_8 PF13523.1 EFE41255.1 - 2.4e-44 150.8 1.3 3.9e-44 150.1 0.9 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFE41255.1 - 0.037 14.2 0.1 0.061 13.4 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ABC_membrane PF00664.18 EFE41256.1 - 6.4e-75 252.0 33.6 4.4e-39 134.5 9.4 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE41256.1 - 3.5e-66 221.6 0.0 5.6e-32 110.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE41256.1 - 4.2e-16 58.8 2.7 2.1e-05 23.8 0.0 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 EFE41256.1 - 3.2e-11 42.4 0.8 0.00042 19.0 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.1 EFE41256.1 - 3.6e-10 39.2 0.1 0.00054 19.4 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 EFE41256.1 - 1e-09 38.7 0.1 0.018 15.0 0.0 4.3 3 1 0 3 3 3 2 AAA domain AAA_17 PF13207.1 EFE41256.1 - 1.2e-08 35.8 0.1 0.0011 19.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFE41256.1 - 1.3e-08 35.0 6.1 8.2e-05 22.6 0.3 3.4 2 1 1 3 3 3 2 AAA ATPase domain DUF87 PF01935.12 EFE41256.1 - 1.4e-07 31.6 0.1 0.00097 19.0 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_22 PF13401.1 EFE41256.1 - 1.8e-06 28.0 1.2 0.15 12.2 0.0 4.0 3 1 1 4 4 4 2 AAA domain DUF258 PF03193.11 EFE41256.1 - 9.3e-06 24.9 0.0 0.14 11.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 EFE41256.1 - 6.3e-05 22.5 3.6 0.099 12.0 0.0 3.7 4 1 0 4 4 4 2 AAA-like domain AAA_18 PF13238.1 EFE41256.1 - 6.4e-05 23.2 0.1 0.11 12.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFE41256.1 - 7.3e-05 22.2 0.1 0.4 10.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain Zeta_toxin PF06414.7 EFE41256.1 - 0.00015 20.9 0.0 0.23 10.5 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_30 PF13604.1 EFE41256.1 - 0.00017 21.2 1.7 0.39 10.2 0.0 4.1 4 0 0 4 4 4 1 AAA domain FtsK_SpoIIIE PF01580.13 EFE41256.1 - 0.00021 20.8 0.0 0.0075 15.7 0.0 2.7 3 0 0 3 3 2 1 FtsK/SpoIIIE family DUF3987 PF13148.1 EFE41256.1 - 0.00028 19.5 0.1 0.38 9.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) AAA_23 PF13476.1 EFE41256.1 - 0.00045 20.6 0.2 0.6 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE41256.1 - 0.00051 19.9 0.1 1.4 8.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 EFE41256.1 - 0.00092 19.0 2.9 0.37 10.7 0.1 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit MobB PF03205.9 EFE41256.1 - 0.0025 17.5 0.2 2.4 7.8 0.0 3.2 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 EFE41256.1 - 0.0032 16.9 0.1 0.42 10.0 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_5 PF07728.9 EFE41256.1 - 0.0052 16.5 0.1 5.5 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 EFE41256.1 - 0.0099 15.8 0.1 1.1 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.4 EFE41256.1 - 0.012 14.3 0.0 0.84 8.1 0.0 3.0 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain MMR_HSR1 PF01926.18 EFE41256.1 - 0.054 13.4 0.1 18 5.3 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase G-alpha PF00503.15 EFE41256.1 - 0.11 11.1 0.0 5.1 5.6 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit COX5A PF02284.11 EFE41257.1 - 7.4e-29 99.8 0.7 8.1e-27 93.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome c oxidase subunit Va Sec62 PF03839.11 EFE41258.1 - 0.14 11.5 2.0 0.15 11.4 1.4 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 CCDC71L PF15374.1 EFE41258.1 - 0.14 11.4 2.8 0.14 11.4 1.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DUF3827 PF12877.2 EFE41258.1 - 0.15 10.1 1.6 0.16 10.0 1.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) NPR3 PF03666.8 EFE41258.1 - 0.74 8.2 4.0 0.85 8.0 2.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_polI_A34 PF08208.6 EFE41258.1 - 8.6 5.9 16.0 10 5.7 11.1 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 ELO PF01151.13 EFE41259.1 - 4.9e-63 212.7 19.9 5.8e-63 212.5 13.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family AA_permease_2 PF13520.1 EFE41262.1 - 1.4e-22 79.9 22.8 1.8e-22 79.5 15.8 1.1 1 0 0 1 1 1 1 Amino acid permease PGM_PMM_III PF02880.11 EFE41262.1 - 0.11 12.5 0.0 2 8.4 0.0 2.2 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III adh_short_C2 PF13561.1 EFE41263.1 - 1.4e-33 116.6 0.0 1.8e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFE41263.1 - 2.6e-30 105.5 0.1 3.2e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE41263.1 - 1.5e-06 28.0 0.4 3.8e-06 26.6 0.2 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE41263.1 - 0.0073 15.7 0.2 0.019 14.4 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family HI0933_like PF03486.9 EFE41263.1 - 0.038 12.4 0.3 0.052 12.0 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_10 PF13460.1 EFE41263.1 - 0.05 13.6 0.2 0.1 12.5 0.2 1.6 1 1 0 1 1 1 0 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 EFE41263.1 - 0.17 11.7 1.0 0.34 10.7 0.7 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1996 PF09362.5 EFE41264.1 - 9.3e-79 264.3 0.0 1.3e-78 263.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) AdoMet_MTase PF07757.8 EFE41264.1 - 0.014 15.5 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Clat_adaptor_s PF01217.15 EFE41267.1 - 4.6e-42 143.1 0.0 7.4e-42 142.4 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MMR_HSR1 PF01926.18 EFE41268.1 - 1.4e-15 57.2 0.0 3.1e-15 56.1 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFE41268.1 - 5.6e-06 26.2 0.0 0.00018 21.3 0.0 2.3 1 1 0 2 2 2 1 Dynamin family AIG1 PF04548.11 EFE41268.1 - 2.1e-05 23.7 0.0 3.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.22 EFE41268.1 - 3.5e-05 23.3 0.1 0.033 13.6 0.0 2.8 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EFE41268.1 - 0.00026 20.1 0.1 0.00061 19.0 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 EFE41268.1 - 0.0028 16.9 0.0 0.0042 16.3 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.13 EFE41268.1 - 0.0042 16.1 0.0 0.007 15.4 0.0 1.4 1 0 0 1 1 1 1 Septin PduV-EutP PF10662.4 EFE41268.1 - 0.087 12.3 0.0 0.21 11.0 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 EFE41268.1 - 0.09 11.9 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit WD40 PF00400.27 EFE41269.1 - 2.6e-53 176.0 18.2 3.2e-09 36.3 0.0 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.2 EFE41269.1 - 2.4e-10 39.9 0.1 5.9e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE41269.1 - 2.9e-10 39.5 0.2 5.6e-10 38.6 0.1 1.4 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 EFE41269.1 - 2.9e-05 22.4 8.8 0.3 9.1 0.2 5.1 3 3 3 6 6 6 3 Nucleoporin Nup120/160 AcylCoA_DH_N PF12418.3 EFE41269.1 - 0.046 13.4 0.1 0.12 12.0 0.1 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase N terminal PRANC PF09372.5 EFE41269.1 - 0.12 12.3 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 PRANC domain PQQ_2 PF13360.1 EFE41269.1 - 0.16 11.3 3.0 0.58 9.5 0.1 2.5 3 0 0 3 3 3 0 PQQ-like domain HORMA PF02301.13 EFE41270.1 - 4.7e-37 127.5 0.0 1.4e-36 125.9 0.0 1.8 3 0 0 3 3 3 1 HORMA domain Nuc_sug_transp PF04142.10 EFE41274.1 - 2.2e-70 236.5 5.2 2.2e-70 236.5 3.6 1.5 1 1 1 2 2 2 1 Nucleotide-sugar transporter EamA PF00892.15 EFE41274.1 - 0.00028 20.9 10.8 0.00028 20.9 7.5 2.7 2 1 0 2 2 2 1 EamA-like transporter family UAA PF08449.6 EFE41274.1 - 0.0024 16.8 11.0 0.0096 14.8 7.6 1.9 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 EFE41274.1 - 0.0024 18.0 7.1 0.0024 18.0 4.9 2.6 2 2 0 2 2 2 1 Multidrug resistance efflux transporter DEAD PF00270.24 EFE41275.1 - 5e-29 100.9 0.1 7.8e-29 100.3 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EFE41275.1 - 6.5e-11 42.4 0.0 1.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EFE41275.1 - 6.1e-05 21.9 0.0 8.3e-05 21.5 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 EFE41275.1 - 0.00054 20.0 0.1 0.0013 18.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 EFE41275.1 - 0.0017 18.5 0.2 0.0039 17.3 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFE41275.1 - 0.0047 16.6 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 EFE41275.1 - 0.01 14.7 0.0 0.02 13.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Flavi_DEAD PF07652.9 EFE41275.1 - 0.032 13.9 0.0 0.2 11.4 0.0 2.0 1 1 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.9 EFE41275.1 - 0.039 13.5 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_10 PF12846.2 EFE41275.1 - 0.041 13.3 0.2 1.7 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain AAA_30 PF13604.1 EFE41275.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain Sec63 PF02889.11 EFE41276.1 - 5.9e-52 176.8 0.0 7.4e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.26 EFE41276.1 - 7.4e-11 41.7 0.0 1.4e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain LRR_8 PF13855.1 EFE41278.1 - 0.0011 18.6 0.2 0.015 15.0 0.0 2.6 2 0 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.28 EFE41278.1 - 0.0012 18.6 1.0 1.6 9.0 0.1 4.0 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.1 EFE41278.1 - 0.0086 16.0 5.6 3 8.1 0.1 4.5 4 0 0 4 4 4 1 Leucine Rich repeat LRR_4 PF12799.2 EFE41278.1 - 0.068 12.8 0.9 0.39 10.3 0.5 2.3 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Acid_PPase PF12689.2 EFE41279.1 - 1.7e-68 229.5 0.0 1.9e-68 229.3 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase NIF PF03031.13 EFE41279.1 - 0.00059 19.5 0.0 0.00081 19.0 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 EFE41279.1 - 0.0067 16.6 0.4 0.2 11.8 0.0 2.8 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase TPR_MLP1_2 PF07926.7 EFE41280.1 - 2.5e-31 108.1 28.5 2.5e-31 108.1 19.7 16.6 4 4 7 12 12 12 4 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.3 EFE41280.1 - 0.00031 20.4 15.7 0.00031 20.4 10.9 22.7 12 8 12 26 26 26 5 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.2 EFE41280.1 - 0.0016 18.2 16.0 0.0016 18.2 11.1 15.4 4 4 10 15 15 15 3 Tropomyosin like T2SF PF00482.18 EFE41280.1 - 0.27 11.1 11.3 2.7 7.9 0.5 5.4 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F TFIIE_beta PF02186.10 EFE41281.1 - 1.1e-06 28.5 0.0 3.7e-06 26.8 0.0 1.9 1 1 0 1 1 1 1 TFIIE beta subunit core domain DHBP_synthase PF00926.14 EFE41282.1 - 3.4e-69 231.9 0.0 8.7e-69 230.6 0.0 1.6 1 1 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase F-box-like PF12937.2 EFE41283.1 - 1.2e-10 40.9 0.8 2.6e-10 39.8 0.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE41283.1 - 2.3e-09 36.6 0.9 1.4e-08 34.1 0.2 2.3 2 0 0 2 2 2 1 F-box domain Pkinase PF00069.20 EFE41284.1 - 3.9e-53 180.2 0.0 2.7e-52 177.5 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41284.1 - 7.2e-21 74.4 0.0 9.7e-21 74.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE41284.1 - 2.5e-10 39.7 0.0 3.5e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFE41284.1 - 0.0069 15.4 0.0 0.1 11.6 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family UQ_con PF00179.21 EFE41285.1 - 1.1e-41 141.5 0.1 1.6e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EFE41285.1 - 0.00036 20.3 0.1 0.0005 19.9 0.1 1.5 1 1 0 1 1 1 1 RWD domain UEV PF05743.8 EFE41285.1 - 0.0069 16.0 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.1 EFE41285.1 - 0.01 15.5 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Nucleos_tra2_C PF07662.8 EFE41286.1 - 2.7e-69 232.8 1.3 2.7e-69 232.8 0.9 2.8 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.15 EFE41286.1 - 1.2e-22 80.0 4.3 1.2e-22 80.0 3.0 3.2 2 1 1 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Prenyltransf PF01255.14 EFE41288.1 - 7.5e-59 198.5 0.1 2.5e-57 193.5 0.1 2.0 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase UbiA PF01040.13 EFE41289.1 - 2e-10 40.3 4.7 2e-10 40.3 3.3 1.9 1 1 0 2 2 2 1 UbiA prenyltransferase family DUF805 PF05656.9 EFE41289.1 - 6.7 6.5 7.4 1.2e+02 2.5 4.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF805) Glyco_transf_20 PF00982.16 EFE41290.1 - 6.3e-181 601.9 0.1 2.2e-97 326.4 0.0 2.0 1 1 1 2 2 2 2 Glycosyltransferase family 20 Glyco_transf_5 PF08323.6 EFE41290.1 - 0.0077 15.7 0.2 0.031 13.7 0.1 2.0 1 1 1 2 2 2 1 Starch synthase catalytic domain MIT PF04212.13 EFE41290.1 - 0.23 11.3 2.4 16 5.4 0.0 2.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Aconitase PF00330.15 EFE41292.1 - 3.5e-175 582.9 0.0 8.1e-175 581.7 0.0 1.6 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFE41292.1 - 3.2e-45 153.4 0.0 5.7e-45 152.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Rad54_N PF08658.5 EFE41293.1 - 9.6e-63 211.5 0.7 1.1e-62 211.3 0.5 1.0 1 0 0 1 1 1 1 Rad54 N terminal EMG1 PF03587.9 EFE41294.1 - 5.4e-78 260.9 0.0 6.2e-78 260.7 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Glyoxalase_2 PF12681.2 EFE41295.1 - 4.5e-07 30.4 0.0 7.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain UQ_con PF00179.21 EFE41296.1 - 2.6e-32 111.1 0.8 2.9e-31 107.7 0.6 1.9 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFE41296.1 - 0.0053 16.5 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFE41296.1 - 0.0075 16.1 0.4 0.01 15.7 0.3 1.4 1 1 0 1 1 1 1 RWD domain Acyl-CoA_dh_N PF02771.11 EFE41297.1 - 2e-24 86.3 0.1 4.3e-24 85.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.19 EFE41297.1 - 3.9e-23 82.1 0.1 7.2e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFE41297.1 - 1.1e-16 60.0 0.0 2.3e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFE41297.1 - 2.8e-08 34.1 0.6 2.8e-08 34.1 0.4 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acetyltransf_13 PF13880.1 EFE41299.1 - 1.8e-26 91.6 0.1 4.6e-26 90.3 0.0 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.1 EFE41299.1 - 2.5e-14 52.5 0.2 7.2e-14 51.0 0.1 1.8 2 0 0 2 2 2 1 zinc-finger of acetyl-transferase ESCO Mucin PF01456.12 EFE41299.1 - 0.015 15.0 43.6 0.015 15.0 30.2 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein NAD_binding_6 PF08030.7 EFE41301.1 - 6.2e-34 117.1 0.0 1e-33 116.4 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFE41301.1 - 3.7e-23 81.4 0.0 1.6e-22 79.3 0.0 2.1 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.14 EFE41301.1 - 2.2e-12 47.1 12.4 4.2e-12 46.2 8.6 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 EFE41301.1 - 1.3e-05 25.2 0.0 2.7e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EFE41301.1 - 0.066 13.7 0.0 0.34 11.4 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain DUF4131 PF13567.1 EFE41301.1 - 0.15 11.4 1.3 0.36 10.2 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) eIF2A PF08662.6 EFE41302.1 - 2.4e-84 281.8 0.1 4.6e-83 277.6 0.0 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 EFE41302.1 - 0.0016 18.2 0.1 1.6 8.7 0.1 4.5 4 0 0 4 4 4 1 WD domain, G-beta repeat CDV3 PF15359.1 EFE41302.1 - 0.011 15.8 2.7 0.011 15.8 1.9 4.7 4 1 2 6 6 6 0 Carnitine deficiency-associated protein 3 FlaG PF03646.10 EFE41302.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.5 3 0 0 3 3 3 0 FlaG protein DUF2855 PF11017.3 EFE41303.1 - 0.2 10.7 0.7 0.21 10.6 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) Selenoprotein_S PF06936.6 EFE41303.1 - 1.4 8.4 9.8 1.8 8.0 6.8 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) RNA_polI_A34 PF08208.6 EFE41303.1 - 2.1 7.9 14.4 2.4 7.8 10.0 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1203 PF06718.6 EFE41305.1 - 1.6e-24 85.9 0.0 1.9e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1203) CorA PF01544.13 EFE41306.1 - 3.5e-18 65.6 1.9 6.5e-18 64.7 1.3 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein STE PF02200.11 EFE41306.1 - 0.0099 16.0 0.0 0.032 14.3 0.0 1.8 2 0 0 2 2 2 1 STE like transcription factor TFIID_20kDa PF03847.8 EFE41307.1 - 8.9e-24 83.5 0.0 1.5e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A F-box PF00646.28 EFE41309.1 - 0.00011 21.7 0.0 0.00021 20.8 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE41309.1 - 0.011 15.4 0.2 0.033 13.9 0.1 1.8 1 0 0 1 1 1 0 F-box-like DASH_Spc34 PF08657.5 EFE41310.1 - 1.4e-57 195.3 9.2 4.5e-55 187.1 6.4 2.0 1 1 0 1 1 1 1 DASH complex subunit Spc34 IncA PF04156.9 EFE41310.1 - 0.00045 19.8 0.5 0.00045 19.8 0.4 1.5 2 0 0 2 2 2 1 IncA protein DUF848 PF05852.6 EFE41310.1 - 0.00048 20.0 3.3 0.00095 19.0 2.3 1.5 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) ISG65-75 PF11727.3 EFE41310.1 - 0.034 13.1 1.4 0.048 12.7 1.0 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein MIF4G_like_2 PF09090.6 EFE41310.1 - 0.052 12.7 1.3 0.58 9.3 0.0 2.1 2 0 0 2 2 2 0 MIF4G like DASH_Spc19 PF08287.6 EFE41310.1 - 0.12 11.9 3.1 0.25 10.9 2.2 1.5 1 0 0 1 1 1 0 Spc19 DUF1136 PF06582.7 EFE41310.1 - 0.28 10.9 1.8 1.4 8.7 1.2 2.3 1 0 0 1 1 1 0 Repeat of unknown function (DUF1136) Prefoldin_2 PF01920.15 EFE41310.1 - 0.89 9.3 10.7 1.6 8.5 0.7 2.8 4 0 0 4 4 4 0 Prefoldin subunit Rpn3_C PF08375.6 EFE41311.1 - 2.1e-24 85.7 0.3 2.1e-24 85.7 0.2 2.5 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 EFE41311.1 - 4.2e-21 75.2 0.1 2.2e-20 72.9 0.0 2.1 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 EFE41311.1 - 0.02 14.6 0.1 0.13 11.9 0.0 2.1 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 polyprenyl_synt PF00348.12 EFE41312.1 - 1.4e-46 158.4 0.0 1.9e-43 148.1 0.0 2.1 2 0 0 2 2 2 2 Polyprenyl synthetase Ank PF00023.25 EFE41313.1 - 1.2e-27 94.2 0.0 3.7e-07 29.6 0.0 4.6 4 1 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.2 EFE41313.1 - 8.3e-25 86.9 6.4 3.2e-11 43.4 0.4 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE41313.1 - 1e-20 73.6 9.2 6.3e-07 29.7 0.5 3.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE41313.1 - 7.8e-16 57.7 5.4 0.00028 21.0 0.3 4.4 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE41313.1 - 4.8e-15 54.1 1.3 0.0043 17.1 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat DUF3387 PF11867.3 EFE41314.1 - 0.19 10.6 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3387) BPL_LplA_LipB PF03099.14 EFE41315.1 - 1.7e-09 37.7 0.0 2.9e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Ras PF00071.17 EFE41316.1 - 2.3e-26 92.1 0.0 2.7e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE41316.1 - 1.8e-07 31.6 0.0 2.4e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE41316.1 - 0.00031 20.0 0.0 0.00034 19.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFE41316.1 - 0.023 13.8 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region CWC25 PF12542.3 EFE41318.1 - 2.3e-26 92.0 0.7 2.3e-26 92.0 0.5 3.9 4 0 0 4 4 4 2 Pre-mRNA splicing factor Cir_N PF10197.4 EFE41318.1 - 3.1e-13 49.4 10.4 3.1e-13 49.4 7.2 4.6 3 1 1 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR DUF3674 PF12426.3 EFE41318.1 - 0.15 11.5 0.6 0.51 9.7 0.1 2.1 2 0 0 2 2 2 0 RNA dependent RNA polymerase PCI PF01399.22 EFE41319.1 - 5.4e-16 58.8 0.5 1.2e-15 57.6 0.0 1.9 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 EFE41319.1 - 4e-07 29.8 0.1 9.9e-07 28.6 0.0 1.6 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 TPR_7 PF13176.1 EFE41319.1 - 0.00031 20.3 0.9 0.05 13.4 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE41319.1 - 0.003 17.3 2.7 0.077 12.9 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFE41319.1 - 0.0076 16.1 0.1 1.9 8.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE41319.1 - 0.023 14.6 3.7 0.15 12.0 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Ipi1_N PF12333.3 EFE41319.1 - 0.033 14.1 0.1 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation TPR_1 PF00515.23 EFE41319.1 - 0.041 13.5 2.5 0.27 10.8 0.0 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFE41319.1 - 0.13 11.9 1.3 0.74 9.4 0.0 2.9 3 1 0 3 3 3 0 TPR repeat TPR_14 PF13428.1 EFE41319.1 - 0.16 12.6 0.7 3.7 8.4 0.0 3.2 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFE41319.1 - 0.26 11.1 3.8 0.33 10.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Corona_M PF01635.13 EFE41320.1 - 5.2 5.9 15.5 0.22 10.4 0.3 2.4 3 0 0 3 3 3 0 Coronavirus M matrix/glycoprotein Peptidase_C65 PF10275.4 EFE41321.1 - 1.4e-67 227.5 0.0 2e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain Pyridox_oxidase PF01243.15 EFE41322.1 - 3.9e-12 46.0 0.0 7.9e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase NIPSNAP PF07978.8 EFE41323.1 - 3.1e-39 133.0 0.4 9.1e-29 99.4 0.1 2.3 2 0 0 2 2 2 2 NIPSNAP Mcm10 PF09332.6 EFE41323.1 - 0.15 11.4 3.8 0.21 10.8 2.6 1.2 1 0 0 1 1 1 0 Mcm10 replication factor RR_TM4-6 PF06459.7 EFE41325.1 - 0.22 11.3 4.4 0.26 11.1 3.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Endostatin PF06482.6 EFE41325.1 - 0.32 10.3 2.8 0.37 10.1 2.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF566 PF04484.7 EFE41325.1 - 8.9 5.7 10.6 10 5.4 7.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF566) S4 PF01479.20 EFE41326.1 - 8.2e-16 57.1 0.0 2.5e-15 55.6 0.0 1.9 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.1 EFE41326.1 - 0.022 14.3 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 S4 domain RasGAP PF00616.14 EFE41326.1 - 0.11 12.1 2.6 0.086 12.4 0.8 1.5 1 1 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase DUF2507 PF10702.4 EFE41326.1 - 0.31 10.6 2.5 0.32 10.6 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2507) PAP1 PF08601.5 EFE41326.1 - 3.1 7.4 19.4 0.16 11.6 8.0 2.0 2 0 0 2 2 2 0 Transcription factor PAP1 Abhydrolase_6 PF12697.2 EFE41327.1 - 2.4e-13 50.4 0.4 8.1e-13 48.7 0.2 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE41327.1 - 4.6e-06 26.3 0.5 0.07 12.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold LCAT PF02450.10 EFE41327.1 - 0.16 10.9 0.2 0.25 10.2 0.2 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase APH PF01636.18 EFE41328.1 - 1.6e-08 34.5 2.9 5.9e-08 32.7 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFE41328.1 - 0.031 13.4 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase AA_permease_2 PF13520.1 EFE41329.1 - 3.1e-64 217.1 43.3 4.2e-64 216.6 30.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE41329.1 - 6.5e-30 103.9 44.0 1.7e-26 92.6 30.5 2.3 1 1 0 1 1 1 1 Amino acid permease FAD_binding_6 PF00970.19 EFE41330.1 - 6e-06 26.3 0.0 1.6e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EFE41330.1 - 6.7e-06 26.6 0.0 0.00059 20.3 0.0 2.3 1 1 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EFE41330.1 - 0.1 12.5 0.0 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Aminotran_5 PF00266.14 EFE41331.1 - 4.3e-29 101.3 0.0 3.9e-18 65.3 0.0 2.2 1 1 1 2 2 2 2 Aminotransferase class-V Aconitase PF00330.15 EFE41332.1 - 4.5e-71 239.7 0.5 1.1e-45 156.0 0.1 2.8 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFE41332.1 - 3.9e-23 81.9 0.0 9.2e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain Peptidase_M22 PF00814.20 EFE41333.1 - 2.3e-84 283.0 0.0 2.7e-84 282.8 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Chrome_Resist PF09828.4 EFE41333.1 - 0.039 14.1 0.0 0.079 13.1 0.0 1.5 1 0 0 1 1 1 0 Chromate resistance exported protein SET PF00856.23 EFE41334.1 - 1.5e-10 41.6 0.0 3e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.6 EFE41334.1 - 2.7e-05 24.0 0.4 0.0001 22.2 0.3 2.0 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding EPL1 PF10513.4 EFE41335.1 - 5.3e-31 108.0 0.7 5.3e-31 108.0 0.5 2.8 2 1 1 3 3 3 1 Enhancer of polycomb-like EF-hand_1 PF00036.27 EFE41336.1 - 5.8e-19 65.8 11.8 7.4e-08 31.1 0.3 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 EFE41336.1 - 6.1e-14 51.8 4.9 3.8e-12 46.1 0.6 2.2 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 EFE41336.1 - 1.1e-13 49.7 7.2 7.9e-07 28.1 0.2 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 EFE41336.1 - 1.6e-13 49.2 4.7 4.9e-05 22.8 0.1 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 EFE41336.1 - 2.6e-12 46.1 9.7 6.4e-06 25.6 0.6 3.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 EFE41336.1 - 3.9e-05 23.3 5.7 0.0064 16.2 0.2 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 EFE41336.1 - 0.00066 19.6 0.0 0.00089 19.2 0.0 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 EFE41336.1 - 0.024 14.5 0.0 0.22 11.4 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain Arylsulfotran_2 PF14269.1 EFE41337.1 - 2.7e-111 371.4 0.2 3.9e-111 370.9 0.2 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.6 EFE41337.1 - 2.4e-17 62.6 0.1 3.9e-16 58.6 0.0 2.1 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Pkinase PF00069.20 EFE41338.1 - 1.1e-34 119.8 0.0 1.4e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41338.1 - 8.6e-10 38.1 0.0 2.3e-08 33.4 0.0 2.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EFE41338.1 - 0.034 12.9 0.1 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinocilin PF15033.1 EFE41339.1 - 0.0006 19.3 0.4 0.00067 19.1 0.3 1.1 1 0 0 1 1 1 1 Kinocilin protein Plasmod_dom_1 PF09715.5 EFE41339.1 - 0.03 14.2 0.6 0.042 13.7 0.4 1.4 1 0 0 1 1 1 0 Plasmodium protein of unknown function (Plasmod_dom_1) DUF817 PF05675.7 EFE41339.1 - 0.062 12.7 0.4 0.059 12.7 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF817) HA2 PF04408.18 EFE41340.1 - 6.9e-20 70.9 0.1 1.7e-19 69.7 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE41340.1 - 3.3e-12 46.0 0.0 7.8e-12 44.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.17 EFE41340.1 - 8.8e-11 41.7 0.0 1.8e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 RWD domain DEAD PF00270.24 EFE41340.1 - 6.9e-10 38.6 0.0 1.3e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.11 EFE41340.1 - 4.7e-09 36.0 0.0 1e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.1 EFE41340.1 - 0.00035 20.7 0.1 0.0012 19.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain DND1_DSRM PF14709.1 EFE41340.1 - 0.0021 18.2 0.0 0.0064 16.7 0.0 1.9 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 T2SE PF00437.15 EFE41340.1 - 0.0035 16.2 0.0 0.0068 15.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.1 EFE41340.1 - 0.0059 16.0 0.1 0.026 14.0 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain UBA PF00627.26 EFE41340.1 - 0.017 14.9 0.0 3.2 7.7 0.0 3.5 3 0 0 3 3 3 0 UBA/TS-N domain AAA_25 PF13481.1 EFE41340.1 - 0.021 14.2 0.0 0.046 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 EFE41340.1 - 0.023 13.8 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.1 EFE41340.1 - 0.032 14.5 0.0 0.088 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain CoA_trans PF01144.18 EFE41340.1 - 0.059 12.5 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Coenzyme A transferase AAA_19 PF13245.1 EFE41340.1 - 0.099 12.4 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain DUF4258 PF14076.1 EFE41340.1 - 0.11 12.5 0.1 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4258) TRAP_alpha PF03896.11 EFE41341.1 - 1.6e-13 50.2 0.0 7.3e-13 48.1 0.0 1.8 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit 6PF2K PF01591.13 EFE41342.1 - 0.033 13.2 1.2 0.053 12.5 0.8 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Med3 PF11593.3 EFE41342.1 - 1.7 7.7 7.2 2.5 7.2 5.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal POT1 PF02765.12 EFE41343.1 - 5.6e-13 49.0 0.0 3.4e-12 46.4 0.0 2.2 2 1 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 IBB PF01749.15 EFE41344.1 - 3.5e-19 68.7 3.0 3.6e-19 68.7 2.1 1.1 1 0 0 1 1 1 1 Importin beta binding domain SURF6 PF04935.7 EFE41344.1 - 0.7 9.1 9.8 0.87 8.8 6.8 1.1 1 0 0 1 1 1 0 Surfeit locus protein 6 DUF3552 PF12072.3 EFE41344.1 - 1.5 8.0 7.4 1.7 7.7 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Arm PF00514.18 EFE41345.1 - 3.3e-94 305.8 9.5 1.1e-14 53.6 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EFE41345.1 - 2.3e-27 95.0 0.0 4e-10 39.8 0.0 5.7 1 1 6 7 7 7 5 HEAT repeats HEAT PF02985.17 EFE41345.1 - 2.5e-20 70.6 0.1 5.4e-06 26.0 0.0 6.9 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.1 EFE41345.1 - 9.9e-20 70.4 8.2 4.6e-09 36.4 0.0 6.2 4 1 3 7 7 7 3 HEAT-like repeat Arm_2 PF04826.8 EFE41345.1 - 3.4e-10 39.4 0.0 0.0022 17.1 0.0 3.9 2 1 2 4 4 4 2 Armadillo-like Adaptin_N PF01602.15 EFE41345.1 - 7.9e-06 24.4 0.0 0.0023 16.3 0.0 2.9 1 1 2 3 3 3 1 Adaptin N terminal region V-ATPase_H_C PF11698.3 EFE41345.1 - 4.3e-05 23.4 0.0 2.7 7.9 0.0 4.6 3 2 0 4 4 4 1 V-ATPase subunit H HEAT_PBS PF03130.11 EFE41345.1 - 0.00027 21.1 1.5 0.65 10.6 0.0 4.8 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Proteasom_PSMB PF10508.4 EFE41345.1 - 0.0023 16.2 0.1 0.1 10.8 0.0 2.7 3 0 0 3 3 3 1 Proteasome non-ATPase 26S subunit RICTOR_V PF14668.1 EFE41345.1 - 0.0032 17.3 0.5 1.9 8.4 0.0 4.1 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 CTNNBL PF08216.6 EFE41345.1 - 0.01 15.4 0.1 53 3.4 0.0 4.6 5 0 0 5 5 5 0 Catenin-beta-like, Arm-motif containing nuclear Atx10homo_assoc PF09759.4 EFE41345.1 - 0.047 13.4 0.0 11 5.8 0.0 3.3 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Mo25 PF08569.6 EFE41345.1 - 0.16 10.9 0.0 0.4 9.6 0.0 1.7 1 1 1 2 2 2 0 Mo25-like Amidase PF01425.16 EFE41346.1 - 5.3e-89 299.0 0.0 1e-88 298.1 0.0 1.4 1 1 0 1 1 1 1 Amidase p450 PF00067.17 EFE41347.1 - 1.3e-60 205.2 0.0 1.5e-60 205.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4485 PF14846.1 EFE41347.1 - 0.19 11.4 1.3 2.4 7.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4485) MFS_1 PF07690.11 EFE41348.1 - 1.3e-19 70.1 24.0 1.1e-15 57.2 11.0 3.0 2 1 0 3 3 3 3 Major Facilitator Superfamily DUF2530 PF10745.4 EFE41348.1 - 1.5 8.8 8.7 0.11 12.5 1.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2530) Trs65 PF12735.2 EFE41350.1 - 2.3e-57 194.6 0.1 3.1e-57 194.2 0.1 1.2 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 FF PF01846.14 EFE41351.1 - 8.1e-60 198.6 16.6 4.9e-15 55.1 0.0 7.0 6 1 0 6 6 6 5 FF domain WW PF00397.21 EFE41351.1 - 5.9e-10 38.8 0.7 1.3e-09 37.7 0.5 1.6 1 0 0 1 1 1 1 WW domain HycH PF07450.6 EFE41351.1 - 0.081 13.0 0.3 0.24 11.4 0.2 1.8 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH ABC_tran PF00005.22 EFE41352.1 - 3.7e-34 117.9 0.0 1.6e-15 57.6 0.0 2.8 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 EFE41352.1 - 7.7e-13 49.0 5.7 0.079 12.9 0.0 4.9 3 2 2 5 5 5 4 AAA domain SMC_N PF02463.14 EFE41352.1 - 3.9e-11 42.6 2.5 0.0029 16.8 0.0 3.9 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 EFE41352.1 - 2.8e-06 26.6 0.1 2 7.3 0.0 4.4 4 1 0 5 5 5 1 AAA ATPase domain AAA_17 PF13207.1 EFE41352.1 - 5.9e-06 27.1 0.5 0.11 13.3 0.0 3.2 3 2 0 3 3 2 2 AAA domain RLI PF04068.10 EFE41352.1 - 1.3e-05 24.6 9.3 4.6e-05 22.9 3.1 2.9 3 0 0 3 3 2 2 Possible Fer4-like domain in RNase L inhibitor, RLI AAA PF00004.24 EFE41352.1 - 1.3e-05 25.3 0.1 0.013 15.6 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE41352.1 - 6.1e-05 23.1 0.0 0.019 15.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.22 EFE41352.1 - 7.9e-05 22.0 2.5 7.9e-05 22.0 1.7 2.6 3 0 0 3 3 3 1 4Fe-4S binding domain Rad17 PF03215.10 EFE41352.1 - 9.1e-05 21.3 0.0 0.14 10.8 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_29 PF13555.1 EFE41352.1 - 9.7e-05 21.8 0.4 0.068 12.7 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.1 EFE41352.1 - 0.0002 21.6 0.0 0.45 10.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFE41352.1 - 0.00023 20.3 0.0 0.71 9.0 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 RNA_helicase PF00910.17 EFE41352.1 - 0.00032 20.8 0.1 0.22 11.7 0.0 3.1 4 0 0 4 4 2 1 RNA helicase AAA_25 PF13481.1 EFE41352.1 - 0.00091 18.6 0.1 0.34 10.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain VirE PF05272.6 EFE41352.1 - 0.00091 18.7 0.1 1.2 8.5 0.0 2.4 2 0 0 2 2 2 2 Virulence-associated protein E MobB PF03205.9 EFE41352.1 - 0.0012 18.5 2.1 0.11 12.1 0.0 2.8 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B Fer4_21 PF14697.1 EFE41352.1 - 0.0014 18.4 8.4 0.0029 17.4 5.8 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain NACHT PF05729.7 EFE41352.1 - 0.0016 18.1 2.4 0.087 12.4 0.0 2.5 2 0 0 2 2 2 1 NACHT domain UPF0079 PF02367.12 EFE41352.1 - 0.0016 18.0 0.5 0.012 15.1 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 EFE41352.1 - 0.0017 18.6 0.1 0.099 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFE41352.1 - 0.0024 17.8 0.2 0.56 10.1 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 EFE41352.1 - 0.0027 17.5 0.1 0.2 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 EFE41352.1 - 0.003 17.0 2.9 0.056 12.8 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_6 PF12837.2 EFE41352.1 - 0.01 15.6 2.1 0.01 15.6 1.5 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_10 PF13237.1 EFE41352.1 - 0.013 15.2 1.3 0.013 15.2 0.9 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Thymidylate_kin PF02223.12 EFE41352.1 - 0.014 14.7 0.1 5.2 6.4 0.0 2.8 3 0 0 3 3 3 0 Thymidylate kinase Miro PF08477.8 EFE41352.1 - 0.016 15.7 0.0 0.94 9.9 0.0 2.7 3 0 0 3 3 2 0 Miro-like protein Fer4_16 PF13484.1 EFE41352.1 - 0.024 15.3 4.2 0.058 14.1 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_5 PF07728.9 EFE41352.1 - 0.024 14.3 0.1 1 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.17 EFE41352.1 - 0.043 12.6 0.4 11 4.7 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain Fer4_8 PF13183.1 EFE41352.1 - 0.046 13.7 7.2 0.14 12.1 5.1 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_30 PF13604.1 EFE41352.1 - 0.055 13.0 0.3 0.65 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 EFE41352.1 - 0.1 12.5 0.1 7.3 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.1 EFE41352.1 - 0.13 10.7 0.6 0.22 9.9 0.0 1.7 2 0 0 2 2 1 0 AAA domain SbcCD_C PF13558.1 EFE41352.1 - 0.13 12.2 0.1 15 5.6 0.0 3.1 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Fer4_17 PF13534.1 EFE41352.1 - 0.13 12.6 4.6 0.16 12.3 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain KaiC PF06745.8 EFE41352.1 - 0.16 11.0 0.1 0.35 9.9 0.1 1.5 1 0 0 1 1 1 0 KaiC PduV-EutP PF10662.4 EFE41352.1 - 0.19 11.2 0.1 0.19 11.2 0.1 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 EFE41352.1 - 0.21 11.1 2.3 0.9 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 EFE41352.1 - 0.24 11.1 2.0 7.9 6.1 0.1 2.6 2 0 0 2 2 2 0 NTPase Fer4_7 PF12838.2 EFE41352.1 - 0.31 11.4 10.9 0.046 14.1 1.3 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.1 EFE41352.1 - 0.35 11.1 11.9 0.056 13.7 1.4 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain T2SE PF00437.15 EFE41352.1 - 0.36 9.6 0.9 1.4 7.7 0.0 2.3 3 0 0 3 3 3 0 Type II/IV secretion system protein SNF2_N PF00176.18 EFE41353.1 - 7.1e-65 218.7 0.1 3.1e-64 216.6 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Chromo PF00385.19 EFE41353.1 - 1.5e-23 82.2 0.3 2.3e-13 49.5 0.0 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.1 EFE41353.1 - 2.7e-19 69.2 0.3 2.1e-18 66.3 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Helicase_C PF00271.26 EFE41353.1 - 9.4e-12 44.6 0.0 3.2e-11 42.9 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE41353.1 - 8e-06 25.7 0.0 6.1e-05 22.9 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3972 PF13118.1 EFE41353.1 - 0.0022 18.0 1.3 0.006 16.6 0.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3972) AAA_22 PF13401.1 EFE41353.1 - 0.0042 17.2 0.0 0.022 14.8 0.0 2.3 1 0 0 1 1 1 1 AAA domain zf-H2C2_2 PF13465.1 EFE41354.1 - 1.4e-06 28.2 1.7 7.4e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.21 EFE41354.1 - 0.097 13.0 0.4 10 6.7 0.0 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type PGK PF00162.14 EFE41355.1 - 8.4e-148 492.0 0.2 9.6e-148 491.8 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase FIVAR PF07554.8 EFE41355.1 - 0.066 13.4 2.1 4.6 7.5 0.0 3.4 4 0 0 4 4 4 0 Uncharacterised Sugar-binding Domain DSS1_SEM1 PF05160.8 EFE41356.1 - 2.4e-20 72.0 13.2 3.1e-20 71.7 9.2 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family DUF2947 PF11163.3 EFE41356.1 - 0.24 10.9 3.9 0.31 10.6 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) DUF3808 PF10300.4 EFE41357.1 - 3.4e-139 464.4 0.0 4.2e-139 464.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) Nup160 PF11715.3 EFE41358.1 - 4.2e-128 427.8 10.5 5.9e-128 427.3 7.3 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_12 PF13424.1 EFE41358.1 - 0.049 13.5 1.0 0.18 11.7 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFE41358.1 - 0.13 12.9 1.2 0.32 11.7 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFE41358.1 - 0.16 11.8 1.2 0.42 10.5 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Rad51 PF08423.6 EFE41359.1 - 3.4e-138 458.7 0.0 4.4e-138 458.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 EFE41359.1 - 8.2e-13 48.1 0.0 1.3e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 EFE41359.1 - 1.1e-06 27.9 0.0 1.5e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 EFE41359.1 - 3.4e-05 23.0 0.1 7.8e-05 21.9 0.1 1.7 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.1 EFE41359.1 - 0.012 15.8 0.0 0.051 13.7 0.0 2.1 1 1 0 1 1 1 0 Helix-hairpin-helix domain HHH PF00633.18 EFE41359.1 - 0.025 14.2 0.5 7.6 6.4 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif DnaB_C PF03796.10 EFE41359.1 - 0.047 12.5 0.0 0.081 11.7 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain PAXNEB PF05625.6 EFE41359.1 - 0.056 12.2 0.1 0.13 11.0 0.0 1.6 2 0 0 2 2 2 0 PAXNEB protein DUF1676 PF07898.8 EFE41361.1 - 0.71 10.1 3.5 0.68 10.2 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) CPL PF08144.6 EFE41362.1 - 1.9e-17 63.4 0.0 1.4e-16 60.6 0.0 2.4 2 0 0 2 2 2 1 CPL (NUC119) domain DUF2890 PF11081.3 EFE41362.1 - 0.029 14.4 11.3 0.12 12.3 7.8 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Hid1 PF12722.2 EFE41362.1 - 0.47 8.0 4.0 0.69 7.5 2.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Daxx PF03344.10 EFE41362.1 - 0.59 8.5 24.0 1.1 7.6 16.6 1.4 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EFE41362.1 - 1.3 6.8 24.7 2 6.1 17.1 1.2 1 0 0 1 1 1 0 Nop14-like family Sporozoite_P67 PF05642.6 EFE41362.1 - 3 5.5 10.6 5.7 4.6 7.3 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3682 PF12446.3 EFE41363.1 - 0.36 11.1 1.9 0.37 11.0 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Gti1_Pac2 PF09729.4 EFE41364.1 - 6e-65 218.2 1.2 1.1e-61 207.5 0.0 3.1 3 0 0 3 3 3 2 Gti1/Pac2 family Zip PF02535.17 EFE41364.1 - 4.3 6.2 17.4 0.051 12.5 5.9 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter CDP-OH_P_transf PF01066.16 EFE41365.1 - 2e-19 69.7 1.7 3.3e-19 69.0 1.1 1.3 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Vps55 PF04133.9 EFE41367.1 - 2.2e-45 153.2 7.3 2.5e-45 153.1 5.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF2798 PF11391.3 EFE41367.1 - 0.31 10.8 0.1 0.31 10.8 0.1 3.1 3 2 1 4 4 4 0 Protein of unknown function (DUF2798) Proteasome PF00227.21 EFE41368.1 - 3.6e-49 166.6 0.3 4.6e-49 166.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFE41368.1 - 2.1e-07 30.1 1.4 2.9e-07 29.6 0.3 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Flg_hook PF02120.11 EFE41368.1 - 0.051 13.2 0.3 21 4.8 0.0 3.1 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK Lysine_decarbox PF03641.9 EFE41369.1 - 2.8e-30 104.8 0.0 4.2e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase IL32 PF15225.1 EFE41369.1 - 0.053 13.4 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 Interleukin 32 Med6 PF04934.9 EFE41370.1 - 4.4e-11 42.5 0.0 1.3e-10 40.9 0.0 1.7 2 0 0 2 2 2 1 MED6 mediator sub complex component RdRP PF05183.7 EFE41371.1 - 1.6e-162 542.2 0.0 2.1e-162 541.8 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase Pro-kuma_activ PF09286.6 EFE41373.1 - 1.2e-30 106.3 0.3 3.8e-30 104.8 0.2 1.8 1 1 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFE41373.1 - 7e-09 35.2 0.0 1.1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Subtilase family DUF3684 PF12449.3 EFE41374.1 - 0 1514.0 0.0 0 1513.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 EFE41374.1 - 8.5e-06 25.4 0.0 2.2e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EFE41374.1 - 0.0035 17.0 0.0 0.0089 15.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WLM PF08325.5 EFE41374.1 - 0.091 12.6 0.1 0.091 12.6 0.0 2.9 3 0 0 3 3 3 0 WLM domain TRAPPC9-Trs120 PF08626.6 EFE41375.1 - 2.7e-123 412.6 0.0 4.7e-123 411.7 0.0 1.3 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit CARDB PF07705.6 EFE41375.1 - 0.01 15.8 0.0 6 6.9 0.0 3.4 3 0 0 3 3 3 0 CARDB Antimicrobial_7 PF08102.6 EFE41375.1 - 0.19 11.7 0.1 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 Scorpion antimicrobial peptide Abhydrolase_6 PF12697.2 EFE41376.1 - 4.9e-09 36.4 0.0 7.6e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE41376.1 - 2.8e-06 27.1 0.0 4.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE41376.1 - 0.0076 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1749 PF08538.5 EFE41376.1 - 0.014 14.2 0.0 0.019 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.3 EFE41376.1 - 0.093 12.5 0.0 0.21 11.4 0.0 1.5 2 0 0 2 2 2 0 Putative lysophospholipase RNA_pol_L_2 PF13656.1 EFE41378.1 - 3.2e-31 106.5 0.0 4.3e-31 106.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 EFE41378.1 - 7.2e-12 44.2 0.0 9.8e-12 43.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain TrmE_N PF10396.4 EFE41379.1 - 5.8e-36 122.9 0.0 1.2e-35 121.9 0.0 1.5 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus GTPase_Cys_C PF12631.2 EFE41379.1 - 4.2e-21 75.1 0.4 2.3e-20 72.7 0.1 2.4 2 1 0 2 2 2 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE MMR_HSR1 PF01926.18 EFE41379.1 - 4.8e-16 58.7 0.0 9.8e-16 57.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFE41379.1 - 6.3e-06 26.1 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.13 EFE41379.1 - 6.4e-05 22.2 0.2 0.0003 20.0 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 EFE41379.1 - 8.9e-05 21.9 0.0 0.018 14.5 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Miro PF08477.8 EFE41379.1 - 0.0015 18.9 0.0 0.004 17.6 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein ABC_tran PF00005.22 EFE41379.1 - 0.058 13.7 0.9 0.13 12.5 0.1 1.9 2 1 0 2 2 2 0 ABC transporter MCM PF00493.18 EFE41379.1 - 0.1 11.3 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family Glyco_hydro_3_C PF01915.17 EFE41379.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain FH2 PF02181.18 EFE41380.1 - 8.4e-82 275.0 5.5 8.4e-82 275.0 3.8 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.8 EFE41380.1 - 1.8e-51 174.1 4.1 1.8e-50 170.9 0.1 3.1 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 EFE41380.1 - 4.1e-49 166.6 3.8 1.1e-47 162.0 1.1 2.6 1 1 1 2 2 2 2 Diaphanous FH3 Domain 2-Hacid_dh_C PF02826.14 EFE41382.1 - 7.3e-49 165.3 0.0 1.2e-48 164.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFE41382.1 - 7.7e-16 57.7 0.0 1.2e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFE41382.1 - 0.0064 16.3 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cation_ATPase_C PF00689.16 EFE41383.1 - 0.02 14.4 4.7 0.039 13.4 3.3 1.5 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus DsbD_2 PF13386.1 EFE41383.1 - 0.77 9.4 7.0 0.26 11.0 0.8 2.2 1 1 1 2 2 2 0 Cytochrome C biogenesis protein transmembrane region DUF2754 PF10953.3 EFE41383.1 - 3.5 7.7 5.0 5.6 7.1 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2754) tRNA-synt_1 PF00133.17 EFE41384.1 - 1.7e-57 194.7 0.0 1.4e-24 86.0 0.1 6.0 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 EFE41384.1 - 4.2e-38 130.4 0.0 7e-38 129.7 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 EFE41384.1 - 4.1e-32 111.3 0.1 7.4e-25 87.4 0.0 4.1 3 1 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EFE41384.1 - 2.5e-14 53.3 0.0 5.3e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 EFE41384.1 - 6.5e-06 25.4 0.0 0.0005 19.2 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 EFE41384.1 - 0.0018 17.1 0.0 0.0038 16.0 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (R) tRNA-synt_1c PF00749.16 EFE41384.1 - 0.076 11.6 0.1 5.5 5.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain zf-C2H2_2 PF12756.2 EFE41385.1 - 9.1e-21 73.8 5.4 1.4e-20 73.2 3.8 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) MBOAT PF03062.14 EFE41387.1 - 1.7e-47 162.1 4.9 3.8e-47 160.9 3.4 1.6 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Herpes_UL56 PF04534.7 EFE41387.1 - 0.014 15.0 0.3 0.014 15.0 0.2 1.5 2 0 0 2 2 2 0 Herpesvirus UL56 protein Gly_transf_sug PF04488.10 EFE41388.1 - 8e-16 58.3 0.0 1.5e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EFE41388.1 - 0.007 14.9 0.2 0.096 11.1 0.0 2.1 2 0 0 2 2 2 1 TcdA/TcdB catalytic glycosyltransferase domain DUF3357 PF11837.3 EFE41388.1 - 0.041 13.7 1.1 8 6.3 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) RNA_pol_Rpc4 PF05132.9 EFE41388.1 - 0.063 13.2 3.4 0.1 12.6 0.5 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 TRAP_alpha PF03896.11 EFE41388.1 - 0.15 11.0 0.0 0.43 9.5 0.0 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF2011 PF09428.5 EFE41388.1 - 1 9.2 19.0 30 4.5 0.0 2.4 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2011) CDC45 PF02724.9 EFE41388.1 - 1.1 7.2 2.7 1.6 6.6 1.9 1.2 1 0 0 1 1 1 0 CDC45-like protein LRR_6 PF13516.1 EFE41389.1 - 0.00075 19.3 6.6 1.9 8.8 0.1 6.5 6 0 0 6 6 6 2 Leucine Rich repeat Pet127 PF08634.5 EFE41391.1 - 2.1e-116 387.8 0.0 2.8e-116 387.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial protein Pet127 SEEEED PF14797.1 EFE41392.1 - 0.044 13.9 12.2 0.089 12.9 8.4 1.5 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex DUF2201_N PF13203.1 EFE41392.1 - 0.31 10.1 8.1 0.42 9.7 5.6 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain GARS_A PF01071.14 EFE41393.1 - 1.8e-83 278.8 0.0 3e-83 278.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 EFE41393.1 - 2.6e-36 124.0 0.3 6.5e-35 119.6 0.0 3.3 4 0 0 4 4 4 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.17 EFE41393.1 - 2.9e-34 118.3 0.1 8.6e-34 116.7 0.0 1.9 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.11 EFE41393.1 - 3.1e-27 94.5 0.4 7.2e-27 93.4 0.3 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.19 EFE41393.1 - 2.4e-16 59.7 2.2 1e-15 57.7 1.0 2.5 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATPgrasp_Ter PF15632.1 EFE41393.1 - 4.9e-09 35.3 0.0 9.2e-09 34.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 EFE41393.1 - 1.3e-08 34.8 0.0 4e-08 33.2 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.17 EFE41393.1 - 5e-05 22.7 0.0 9.8e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EFE41393.1 - 0.0003 20.6 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.12 EFE41393.1 - 0.00038 19.8 0.0 0.0008 18.7 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.6 EFE41393.1 - 0.069 12.6 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Glyco_hydro_18 PF00704.23 EFE41394.1 - 4.5e-85 286.1 10.2 1.3e-84 284.6 7.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Actin PF00022.14 EFE41395.1 - 7.6e-140 465.7 0.0 9e-140 465.5 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 EFE41395.1 - 0.08 13.3 0.1 0.25 11.7 0.0 1.8 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Fes1 PF08609.5 EFE41396.1 - 3.7e-32 110.6 5.8 3.1e-31 107.7 2.6 2.2 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 EFE41396.1 - 1.5e-17 63.5 2.4 9e-09 35.4 0.3 2.3 1 1 1 2 2 2 2 HEAT repeats HEAT_EZ PF13513.1 EFE41396.1 - 3.7e-09 36.7 0.1 4e-06 27.1 0.0 3.0 2 1 1 3 3 3 2 HEAT-like repeat HEAT PF02985.17 EFE41396.1 - 7.5e-09 34.9 0.0 0.0006 19.6 0.0 2.8 2 0 0 2 2 2 2 HEAT repeat Arm PF00514.18 EFE41396.1 - 4.3e-07 29.5 0.0 0.016 15.0 0.0 2.7 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.15 EFE41396.1 - 0.0002 19.8 0.1 0.00037 18.9 0.0 1.4 2 0 0 2 2 2 1 Adaptin N terminal region RICTOR_V PF14668.1 EFE41396.1 - 0.0003 20.6 0.0 0.00051 19.9 0.0 1.4 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_N PF03224.9 EFE41396.1 - 0.021 13.9 0.1 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit H V-ATPase_H_C PF11698.3 EFE41396.1 - 0.024 14.5 0.2 1.6 8.6 0.0 2.2 1 1 1 2 2 2 0 V-ATPase subunit H Cnd1 PF12717.2 EFE41396.1 - 0.074 12.8 0.0 0.22 11.3 0.0 1.7 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 FliT PF05400.8 EFE41396.1 - 0.1 12.9 5.0 0.8 10.1 0.2 3.2 1 1 1 3 3 3 0 Flagellar protein FliT FPL PF09758.4 EFE41396.1 - 0.12 12.1 0.1 1.8 8.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein UPF0220 PF05255.6 EFE41397.1 - 6.1e-66 220.7 3.4 6.8e-66 220.6 2.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) G3P_antiterm PF04309.7 EFE41397.1 - 0.088 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator VIT1 PF01988.14 EFE41398.1 - 0.34 10.3 1.6 0.37 10.2 1.1 1.0 1 0 0 1 1 1 0 VIT family Pkinase PF00069.20 EFE41399.1 - 3e-70 236.3 0.0 3e-70 236.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41399.1 - 3.1e-31 108.4 0.0 6.5e-31 107.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_C PF00433.19 EFE41399.1 - 3e-11 43.6 0.2 3e-11 43.6 0.1 2.7 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFE41399.1 - 4.6e-10 38.9 0.0 8.6e-10 38.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE41399.1 - 0.0085 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EFE41399.1 - 0.076 12.3 2.5 0.2 10.9 0.0 2.4 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL Defensin_big PF14862.1 EFE41399.1 - 0.11 12.5 0.2 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Big defensin Peptidase_S49_N PF08496.5 EFE41399.1 - 0.38 10.5 4.8 0.76 9.5 3.4 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GH-E PF14410.1 EFE41400.1 - 0.082 13.0 0.3 0.18 11.9 0.2 1.5 1 0 0 1 1 1 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues AAA PF00004.24 EFE41401.1 - 1.1e-40 138.8 0.1 3.2e-40 137.3 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFE41401.1 - 0.00013 21.0 0.0 0.00052 19.1 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 EFE41401.1 - 0.00019 21.1 1.5 0.00079 19.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFE41401.1 - 0.00022 21.2 1.4 0.0081 16.1 0.0 2.9 2 2 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 EFE41401.1 - 0.00096 19.2 1.5 0.022 14.9 0.0 2.9 2 1 0 3 3 2 1 AAA domain PhoH PF02562.11 EFE41401.1 - 0.0012 18.1 0.3 0.041 13.1 0.1 2.5 2 0 0 2 2 2 1 PhoH-like protein AAA_2 PF07724.9 EFE41401.1 - 0.0024 17.7 2.7 0.0049 16.7 0.0 2.8 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EFE41401.1 - 0.0056 15.6 3.5 0.03 13.2 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 EFE41401.1 - 0.0063 15.6 0.1 0.02 14.0 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 EFE41401.1 - 0.0094 15.8 0.0 0.029 14.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE41401.1 - 0.013 15.2 0.3 0.032 13.9 0.2 1.6 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 EFE41401.1 - 0.02 14.3 0.1 0.04 13.3 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 EFE41401.1 - 0.038 13.3 1.3 0.44 9.9 0.1 2.5 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.1 EFE41401.1 - 0.16 12.7 0.1 0.16 12.7 0.1 3.1 2 2 0 2 2 2 0 AAA domain AAA_11 PF13086.1 EFE41401.1 - 0.51 9.8 0.0 0.51 9.8 0.0 2.8 2 2 0 2 2 1 0 AAA domain TauD PF02668.11 EFE41402.1 - 3.3e-21 76.1 0.5 1.3e-13 51.2 0.0 2.1 2 0 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family MaoC_dehydratas PF01575.14 EFE41403.1 - 1.4e-27 95.5 0.0 2.1e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 EFE41403.1 - 2.3e-10 40.3 0.0 1.3e-06 28.2 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Methyltransf_31 PF13847.1 EFE41404.1 - 2.1e-12 46.8 0.0 3.3e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFE41404.1 - 6.4e-11 41.9 0.0 9.8e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 EFE41404.1 - 3.8e-10 40.3 0.0 8.1e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE41404.1 - 2.8e-09 37.0 0.0 6.6e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE41404.1 - 2.2e-07 31.2 0.0 5.5e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 EFE41404.1 - 3.2e-07 29.6 0.0 6e-07 28.7 0.0 1.4 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_23 PF13489.1 EFE41404.1 - 4.1e-06 26.6 0.0 9.3e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EFE41404.1 - 6e-06 25.1 0.0 8.5e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.9 EFE41404.1 - 1.6e-05 24.3 0.0 2.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EFE41404.1 - 1.6e-05 25.1 0.0 5.1e-05 23.5 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain CMAS PF02353.15 EFE41404.1 - 2.1e-05 23.7 0.0 3.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 EFE41404.1 - 0.0003 21.1 0.0 0.0006 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFE41404.1 - 0.00058 19.8 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 EFE41404.1 - 0.0031 16.6 0.1 0.0045 16.1 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.4 EFE41404.1 - 0.0087 15.5 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.1 EFE41404.1 - 0.021 14.5 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EFE41404.1 - 0.024 14.1 0.2 0.04 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.13 EFE41404.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.10 EFE41404.1 - 0.071 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Per1 PF04080.8 EFE41405.1 - 9.2e-79 264.6 13.8 1.1e-78 264.3 9.5 1.0 1 0 0 1 1 1 1 Per1-like Orai-1 PF07856.7 EFE41405.1 - 0.12 11.9 2.8 0.21 11.1 2.0 1.4 1 0 0 1 1 1 0 Mediator of CRAC channel activity PGM_PMM_I PF02878.11 EFE41406.1 - 2.7e-17 62.5 1.0 3e-08 33.2 0.0 3.2 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EFE41406.1 - 1e-15 57.8 0.3 6.8e-15 55.2 0.1 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EFE41406.1 - 4.1e-10 39.5 0.3 1.5e-09 37.7 0.1 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.11 EFE41406.1 - 0.0005 20.0 0.3 0.002 18.1 0.2 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DEAD PF00270.24 EFE41407.1 - 5.2e-47 159.4 0.0 8.3e-47 158.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE41407.1 - 6.2e-26 90.0 0.0 1.3e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE41407.1 - 0.00072 19.4 0.0 0.002 17.9 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EFE41407.1 - 0.049 13.3 0.3 0.22 11.3 0.0 2.1 2 0 0 2 2 2 0 Part of AAA domain Brix PF04427.13 EFE41408.1 - 4.5e-57 192.8 0.5 6.1e-57 192.3 0.3 1.2 1 0 0 1 1 1 1 Brix domain Lum_binding PF00677.12 EFE41409.1 - 3.3e-27 94.1 0.0 2.1e-12 46.7 0.0 2.2 2 0 0 2 2 2 2 Lumazine binding domain Lumazine_bd_2 PF12893.2 EFE41409.1 - 0.026 15.0 0.1 0.065 13.7 0.0 1.6 1 1 0 1 1 1 0 Putative lumazine-binding CoA_transf_3 PF02515.12 EFE41410.1 - 3.1e-60 202.7 0.0 5.2e-60 201.9 0.0 1.4 1 0 0 1 1 1 1 CoA-transferase family III PHD PF00628.24 EFE41411.1 - 5.3e-07 29.2 9.1 9.3e-07 28.4 6.3 1.4 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.1 EFE41411.1 - 0.048 13.9 0.3 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Prok-RING_1 PF14446.1 EFE41411.1 - 0.091 12.5 6.2 0.21 11.3 4.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 FYVE_2 PF02318.11 EFE41411.1 - 0.15 11.9 2.3 0.26 11.1 1.6 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger PHD_2 PF13831.1 EFE41411.1 - 0.78 9.1 11.6 0.19 11.0 4.6 2.4 2 1 0 2 2 2 0 PHD-finger Band_7 PF01145.20 EFE41412.1 - 2.6e-26 92.6 2.1 4.1e-26 91.9 1.4 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family UPF0149 PF03695.8 EFE41412.1 - 0.052 13.4 0.2 0.96 9.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0149) Ribosomal_L27e PF01777.13 EFE41414.1 - 1.6e-36 124.2 3.4 2.5e-36 123.6 2.4 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family SMAP PF15477.1 EFE41414.1 - 0.15 12.3 1.6 0.35 11.1 1.1 1.6 1 1 0 1 1 1 0 Small acidic protein family LPP PF04728.8 EFE41415.1 - 4.5e-10 39.1 8.3 0.27 11.0 0.2 7.3 5 2 0 6 6 6 4 Lipoprotein leucine-zipper Reo_sigmaC PF04582.7 EFE41415.1 - 0.027 13.6 39.7 0.055 12.6 0.0 7.9 8 2 1 9 9 9 0 Reovirus sigma C capsid protein Ish1 PF10281.4 EFE41415.1 - 0.027 14.5 1.1 24 5.0 0.0 5.9 8 0 0 8 8 8 0 Putative stress-responsive nuclear envelope protein DUF948 PF06103.6 EFE41415.1 - 0.5 10.2 0.0 0.5 10.2 0.0 11.8 13 1 2 15 15 15 0 Bacterial protein of unknown function (DUF948) TRAM_LAG1_CLN8 PF03798.11 EFE41416.1 - 1.1e-47 162.1 15.2 1.7e-47 161.5 10.5 1.3 1 0 0 1 1 1 1 TLC domain SWIB PF02201.13 EFE41417.1 - 1.2e-11 44.1 0.0 7.1e-11 41.6 0.0 2.1 1 1 1 2 2 2 1 SWIB/MDM2 domain DUF4410 PF14366.1 EFE41417.1 - 0.073 12.7 0.3 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4410) PCI PF01399.22 EFE41418.1 - 2e-19 69.8 1.0 3.9e-19 68.9 0.1 2.0 2 1 0 2 2 2 1 PCI domain DDRGK PF09756.4 EFE41418.1 - 0.00012 21.5 0.1 0.00026 20.4 0.1 1.5 1 0 0 1 1 1 1 DDRGK domain TPR_1 PF00515.23 EFE41418.1 - 0.00039 19.8 0.3 4.3 7.1 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE41418.1 - 0.0004 19.9 3.8 24 4.9 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE41418.1 - 0.00088 19.7 3.3 21 6.1 0.0 5.7 5 2 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFE41418.1 - 0.00089 19.1 12.5 0.45 10.4 0.4 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE41418.1 - 0.0019 17.8 3.4 1.4 8.8 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE41418.1 - 0.0046 16.7 3.5 46 4.2 0.2 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFE41418.1 - 0.0082 16.4 1.7 1.6 9.3 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat PCI_Csn8 PF10075.4 EFE41418.1 - 0.058 13.1 0.2 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 HTH_Crp_2 PF13545.1 EFE41418.1 - 0.065 13.0 0.1 15 5.4 0.1 3.1 2 1 1 3 3 3 0 Crp-like helix-turn-helix domain AAA_22 PF13401.1 EFE41418.1 - 0.11 12.6 1.5 0.86 9.7 0.1 2.7 2 2 0 2 2 2 0 AAA domain Prefoldin_2 PF01920.15 EFE41418.1 - 0.13 11.9 1.4 0.58 9.9 0.5 2.3 2 0 0 2 2 2 0 Prefoldin subunit TPR_16 PF13432.1 EFE41418.1 - 0.25 12.0 13.5 2.4 8.9 0.0 5.4 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFE41418.1 - 0.48 10.9 8.1 19 5.9 0.0 5.3 6 1 1 7 7 6 0 Tetratricopeptide repeat WD40 PF00400.27 EFE41419.1 - 4e-35 118.4 2.8 1.6e-08 34.1 0.0 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat Sof1 PF04158.9 EFE41419.1 - 1e-28 99.1 13.1 1.7e-28 98.4 9.1 1.4 1 0 0 1 1 1 1 Sof1-like domain Cytochrom_D1 PF02239.11 EFE41419.1 - 0.02 13.1 0.1 0.057 11.6 0.1 1.8 1 1 0 1 1 1 0 Cytochrome D1 heme domain adh_short PF00106.20 EFE41420.1 - 1.2e-20 74.1 0.1 2e-20 73.3 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE41420.1 - 4.3e-15 56.1 0.0 8.4e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE41420.1 - 1.6e-05 24.6 0.1 4e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 KR domain DUF2306 PF10067.4 EFE41421.1 - 8.7e-15 54.7 9.0 8.7e-15 54.7 6.3 2.3 3 0 0 3 3 3 1 Predicted membrane protein (DUF2306) Glyoxalase_2 PF12681.2 EFE41423.1 - 1.3e-13 51.5 0.0 1.9e-13 50.9 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 EFE41423.1 - 3.2e-06 27.1 0.0 4.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TRA-1_regulated PF02343.11 EFE41423.1 - 0.079 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 TRA-1 regulated protein R03H10.4 PUF PF00806.14 EFE41424.1 - 5.4e-14 50.7 0.0 1.3 8.6 0.0 8.0 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat Pyridoxal_deC PF00282.14 EFE41425.1 - 1.6e-77 260.5 0.0 1.9e-77 260.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 EFE41425.1 - 1.5e-07 30.5 0.0 2.1e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EFE41425.1 - 2.7e-06 26.7 0.0 3.6e-06 26.3 0.0 1.3 1 1 0 1 1 1 1 Beta-eliminating lyase SLA_LP_auto_ag PF05889.8 EFE41425.1 - 0.055 11.9 0.0 0.096 11.1 0.0 1.3 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) RINT1_TIP1 PF04437.8 EFE41426.1 - 1.7e-147 492.0 0.2 4.9e-147 490.4 0.0 1.8 2 0 0 2 2 2 1 RINT-1 / TIP-1 family ALMT PF11744.3 EFE41426.1 - 0.57 8.7 2.4 0.88 8.1 1.7 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF572 PF04502.8 EFE41426.1 - 4 6.5 7.0 6.3 5.9 4.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2203 PF09969.4 EFE41426.1 - 4.8 7.4 6.8 16 5.7 2.3 3.2 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) DNA_ligase_A_M PF01068.16 EFE41427.1 - 2.1e-47 161.1 0.0 1.1e-44 152.2 0.0 2.4 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EFE41427.1 - 3.1e-42 144.3 0.0 5e-42 143.7 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EFE41427.1 - 4e-19 68.8 0.1 2.4e-18 66.3 0.0 2.4 3 0 0 3 3 3 1 ATP dependent DNA ligase C terminal region YukD PF08817.5 EFE41427.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Peptidase_C36 PF05415.6 EFE41427.1 - 0.14 12.0 0.0 0.45 10.4 0.0 1.8 2 0 0 2 2 2 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase DJ-1_PfpI PF01965.19 EFE41428.1 - 6.7e-21 74.2 0.4 1.6e-20 73.0 0.3 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family DJ-1_PfpI_N PF13587.1 EFE41428.1 - 0.00025 20.4 0.0 0.00082 18.8 0.0 1.9 2 1 0 2 2 2 1 N-terminal domain of DJ-1_PfpI family GST_N_3 PF13417.1 EFE41429.1 - 4.4e-08 33.2 0.0 8.7e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE41429.1 - 1.9e-07 31.0 0.0 4.4e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE41429.1 - 6.9e-07 29.0 2.0 1.3e-06 28.2 0.6 2.1 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFE41429.1 - 0.00014 21.9 0.0 0.0003 20.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE41429.1 - 0.012 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain FA_desaturase PF00487.19 EFE41430.1 - 1 8.7 6.1 10 5.4 0.0 2.3 2 0 0 2 2 2 0 Fatty acid desaturase Metallopep PF12044.3 EFE41431.1 - 6.5e-140 466.3 0.0 9e-140 465.8 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family NAD_binding_1 PF00175.16 EFE41432.1 - 6.9e-29 100.6 0.0 1.1e-28 99.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFE41432.1 - 1.9e-22 79.2 0.0 4e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EFE41432.1 - 2e-08 34.2 0.0 2.1e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain HemX PF04375.9 EFE41432.1 - 0.17 10.4 0.0 0.25 9.8 0.0 1.1 1 0 0 1 1 1 0 HemX Ribosomal_L18ae PF01775.12 EFE41433.1 - 4.5e-59 197.7 1.4 5.7e-59 197.4 1.0 1.1 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain PCI PF01399.22 EFE41434.1 - 1e-09 38.6 0.0 1.9e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 PCI domain DUF433 PF04255.9 EFE41434.1 - 0.077 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF433) BTB PF00651.26 EFE41435.1 - 5.9e-08 32.6 0.0 2.4e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.10 EFE41435.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain tRNA-synt_2 PF00152.15 EFE41436.1 - 3.6e-81 272.5 0.0 4.5e-81 272.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFE41436.1 - 1.9e-09 37.2 0.0 3.7e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EFE41436.1 - 1.4e-05 24.4 0.0 0.0075 15.4 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 EFE41436.1 - 0.038 13.5 0.0 7.7 6.0 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) zf-Tim10_DDP PF02953.10 EFE41437.1 - 5.5e-24 83.2 2.6 7.2e-24 82.8 1.8 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Tom5 PF10642.4 EFE41437.1 - 0.57 9.8 0.1 0.57 9.8 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase PG_binding_1 PF01471.13 EFE41438.1 - 0.022 14.7 0.0 4.5 7.3 0.0 3.5 4 0 0 4 4 4 0 Putative peptidoglycan binding domain CLTH PF10607.4 EFE41439.1 - 8.3e-27 93.6 0.0 1.6e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.1 EFE41439.1 - 2.7e-16 58.9 1.6 9.2e-16 57.2 1.1 2.0 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.7 EFE41439.1 - 3.6e-05 23.0 0.0 6.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.1 EFE41439.1 - 0.00037 20.2 0.6 0.00066 19.4 0.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFE41439.1 - 0.0021 17.6 0.6 0.0037 16.9 0.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE41439.1 - 0.0024 17.5 0.4 0.0044 16.7 0.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFE41439.1 - 0.0027 17.6 1.2 0.005 16.8 0.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE41439.1 - 0.026 14.1 1.0 0.053 13.1 0.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFE41439.1 - 0.29 11.0 2.7 0.35 10.7 0.8 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING SAD_SRA PF02182.12 EFE41440.1 - 5.6e-19 67.9 0.0 1.1e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 SAD/SRA domain FAST_1 PF06743.10 EFE41440.1 - 0.093 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 2OG-FeII_Oxy PF03171.15 EFE41441.1 - 0.0014 18.8 0.0 0.0026 17.9 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Clr2 PF10383.4 EFE41442.1 - 1e-19 70.9 0.0 2.1e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Transcription-silencing protein Clr2 ABC_membrane_2 PF06472.10 EFE41443.1 - 6.4e-93 310.9 0.8 1e-92 310.2 0.0 1.7 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EFE41443.1 - 1.6e-18 67.3 0.0 8e-18 65.0 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.1 EFE41443.1 - 0.00067 19.1 0.0 0.074 12.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.1 EFE41443.1 - 0.0024 17.9 0.0 0.0078 16.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFE41443.1 - 0.014 15.5 0.4 0.4 10.8 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 EFE41443.1 - 0.024 14.9 3.6 0.24 11.6 2.5 2.2 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFE41443.1 - 0.041 13.0 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 EFE41443.1 - 0.046 13.7 0.0 0.18 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain ALIX_LYPXL_bnd PF13949.1 EFE41443.1 - 0.046 12.6 0.3 0.074 12.0 0.2 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV AAA_19 PF13245.1 EFE41443.1 - 0.083 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain SMC_N PF02463.14 EFE41443.1 - 0.091 11.9 0.1 3.1 6.9 0.1 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain LRR_4 PF12799.2 EFE41444.1 - 5.9e-36 121.5 48.3 7.9e-11 41.3 2.0 7.9 3 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE41444.1 - 5e-19 67.7 34.9 1.3e-06 28.0 4.8 5.4 2 1 2 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 EFE41444.1 - 1.2e-12 45.9 37.7 0.17 12.0 0.9 10.9 11 0 0 11 11 11 6 Leucine Rich Repeat LRR_7 PF13504.1 EFE41444.1 - 1.5e-10 39.4 25.8 2.4 8.7 0.8 10.6 10 1 0 10 10 10 4 Leucine rich repeat LRR_9 PF14580.1 EFE41444.1 - 6.2e-10 38.9 14.3 0.00019 21.0 2.5 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.1 EFE41444.1 - 1.9e-09 36.5 33.4 0.38 10.9 0.3 10.4 6 3 5 11 11 11 4 Leucine Rich repeat DUF4340 PF14238.1 EFE41444.1 - 0.041 13.5 0.7 0.23 11.1 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4340) WHIM3 PF15614.1 EFE41444.1 - 0.84 9.4 3.7 16 5.3 1.5 2.8 2 1 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 3 NIF PF03031.13 EFE41445.1 - 1.6e-51 174.1 0.5 2.3e-51 173.6 0.4 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pkinase PF00069.20 EFE41446.1 - 2e-24 86.1 0.0 3e-24 85.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41446.1 - 1.6e-07 30.6 0.0 2.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE41446.1 - 0.0088 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE41446.1 - 0.028 13.3 0.0 0.043 12.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 EFE41446.1 - 0.08 12.6 0.9 3.3 7.3 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family RRM_6 PF14259.1 EFE41448.1 - 0.026 14.5 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) GHMP_kinases_C PF08544.8 EFE41448.1 - 0.061 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 GHMP kinases C terminal RRM_1 PF00076.17 EFE41448.1 - 0.063 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldo_ket_red PF00248.16 EFE41449.1 - 9.8e-53 178.8 0.0 1.1e-52 178.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RRM_1 PF00076.17 EFE41450.1 - 2e-66 219.5 0.8 9.5e-15 53.9 0.0 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41450.1 - 8.5e-54 179.4 0.2 1.5e-11 44.0 0.0 6.1 5 1 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41450.1 - 2.7e-29 100.7 1.1 2.9e-05 23.8 0.0 6.5 6 1 0 6 6 6 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EFE41450.1 - 9.4e-07 28.5 0.3 12 5.6 0.0 6.0 6 0 0 6 6 6 3 Limkain b1 Nup35_RRM_2 PF14605.1 EFE41450.1 - 0.00043 19.9 0.4 0.059 13.1 0.0 3.9 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Rota_NS53 PF00981.12 EFE41450.1 - 0.21 10.2 0.1 0.31 9.6 0.1 1.2 1 0 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) Pkinase PF00069.20 EFE41451.1 - 1.2e-28 99.9 0.0 1.6e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41451.1 - 6.4e-27 94.2 0.0 8.2e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE41451.1 - 5.4e-05 22.3 0.0 7.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE41451.1 - 0.00019 20.5 0.0 0.00034 19.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.17 EFE41451.1 - 0.0033 16.7 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 EFE41451.1 - 0.0072 16.0 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE41451.1 - 0.018 14.6 1.2 0.18 11.3 0.9 2.0 1 1 1 2 2 2 0 Choline/ethanolamine kinase YukC PF10140.4 EFE41451.1 - 0.025 13.1 0.0 0.033 12.7 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC PIP49_C PF12260.3 EFE41451.1 - 0.027 13.8 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Seadorna_VP7 PF07387.6 EFE41451.1 - 0.03 13.1 0.3 0.17 10.6 0.0 1.9 2 0 0 2 2 2 0 Seadornavirus VP7 WaaY PF06176.6 EFE41451.1 - 0.092 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) HD PF01966.17 EFE41452.1 - 1.2e-05 25.2 0.1 2.1e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 HD domain SRI PF08236.6 EFE41452.1 - 0.058 13.3 0.5 14 5.7 0.0 2.6 3 0 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain Sec61_beta PF03911.11 EFE41453.1 - 6.2e-18 64.3 0.4 1.1e-17 63.5 0.3 1.3 1 0 0 1 1 1 1 Sec61beta family DUF1129 PF06570.6 EFE41454.1 - 1.9 7.7 12.1 0.24 10.6 5.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) SDA1 PF05285.7 EFE41455.1 - 0.0026 17.1 5.1 0.0027 17.0 3.6 1.0 1 0 0 1 1 1 1 SDA1 TFIIF_alpha PF05793.7 EFE41455.1 - 2.3 6.4 17.7 2.7 6.2 12.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC27 PF09507.5 EFE41455.1 - 7 5.7 11.8 8.4 5.4 8.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PCNA_C PF02747.10 EFE41456.1 - 6.9e-53 177.9 0.0 2.9e-52 175.9 0.0 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.13 EFE41456.1 - 4.3e-46 155.5 3.0 7.6e-46 154.7 2.1 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad9 PF04139.8 EFE41456.1 - 2.2e-07 30.2 0.0 2.6e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.11 EFE41456.1 - 3.5e-05 22.7 0.1 0.0002 20.2 0.0 1.8 1 1 1 2 2 2 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.7 EFE41456.1 - 0.046 12.6 0.0 2.1 7.2 0.0 2.2 2 0 0 2 2 2 0 Hus1-like protein Vezatin PF12632.2 EFE41457.1 - 6.7e-55 185.8 0.3 1.3e-54 184.9 0.2 1.5 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes MatE PF01554.13 EFE41457.1 - 0.012 15.2 0.2 2.4 7.7 0.2 2.2 1 1 0 2 2 2 0 MatE TetR_C_9 PF14514.1 EFE41457.1 - 0.015 15.0 0.9 0.032 14.0 0.1 1.9 2 0 0 2 2 2 0 Transcriptional regulator, TetR, C-terminal Polysacc_synt_C PF14667.1 EFE41457.1 - 0.018 14.8 6.7 0.03 14.1 4.7 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain VAD1-2 PF15310.1 EFE41458.1 - 0.013 15.1 1.4 0.015 14.9 1.0 1.1 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling SelP_N PF04592.9 EFE41458.1 - 0.079 12.3 0.0 0.092 12.1 0.0 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Ank_2 PF12796.2 EFE41459.1 - 7.2e-57 189.7 8.3 2.4e-13 50.2 0.4 6.2 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 EFE41459.1 - 1.8e-36 122.1 0.5 1.6e-05 24.4 0.0 10.3 10 1 0 10 10 10 7 Ankyrin repeat Ank_4 PF13637.1 EFE41459.1 - 1.4e-33 114.6 4.3 3.1e-05 24.3 0.0 7.5 5 1 2 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE41459.1 - 3.3e-28 97.0 8.3 1.5e-08 34.6 0.7 6.9 4 2 3 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE41459.1 - 1.6e-21 74.1 2.7 0.04 14.1 0.1 10.8 12 1 0 12 12 12 5 Ankyrin repeat F-box-like PF12937.2 EFE41459.1 - 0.0038 16.9 0.1 0.0077 15.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE41459.1 - 0.07 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 F-box domain CH PF00307.26 EFE41460.1 - 4.3e-06 26.7 0.0 0.039 14.0 0.0 2.7 2 1 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 EFE41460.1 - 0.0007 19.1 0.0 0.38 10.4 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain IQ PF00612.22 EFE41460.1 - 0.0076 15.7 1.4 0.022 14.3 1.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif HAP2-GCS1 PF10699.4 EFE41460.1 - 0.27 11.2 1.1 0.53 10.2 0.7 1.4 1 0 0 1 1 1 0 Male gamete fusion factor DUF1510 PF07423.6 EFE41461.1 - 0.0013 18.1 1.4 0.0016 17.8 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Ctr PF04145.10 EFE41461.1 - 0.0024 17.9 0.0 0.0029 17.6 0.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Rtf2 PF04641.7 EFE41461.1 - 0.0027 16.9 3.3 0.003 16.8 2.3 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger BLVR PF06375.6 EFE41461.1 - 0.0027 17.5 9.9 0.0032 17.3 6.8 1.1 1 0 0 1 1 1 1 Bovine leukaemia virus receptor (BLVR) SHR3_chaperone PF08229.6 EFE41461.1 - 0.013 14.4 2.4 0.016 14.1 1.6 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 RNA_pol_Rpc4 PF05132.9 EFE41461.1 - 0.014 15.3 1.0 0.014 15.3 0.7 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF1632 PF07857.7 EFE41461.1 - 0.035 13.3 0.0 0.04 13.1 0.0 1.0 1 0 0 1 1 1 0 CEO family (DUF1632) DUF1168 PF06658.7 EFE41461.1 - 0.046 13.2 11.8 0.055 12.9 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) K_trans PF02705.11 EFE41461.1 - 0.05 11.9 0.0 0.053 11.8 0.0 1.0 1 0 0 1 1 1 0 K+ potassium transporter DUF1206 PF06724.6 EFE41461.1 - 0.074 12.8 0.4 0.13 12.0 0.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) MFS_Mycoplasma PF07672.8 EFE41461.1 - 0.08 12.1 0.0 0.096 11.8 0.0 1.0 1 0 0 1 1 1 0 Mycoplasma MFS transporter Eapp_C PF10238.4 EFE41461.1 - 0.095 12.6 0.6 0.1 12.4 0.4 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Mycobact_memb PF05423.8 EFE41461.1 - 0.13 12.0 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Mycobacterium membrane protein DDE_Tnp_IS1595 PF12762.2 EFE41461.1 - 0.16 11.7 2.3 0.22 11.3 1.6 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain PPP1R35_C PF15503.1 EFE41461.1 - 0.26 10.8 3.5 0.35 10.3 2.4 1.1 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus OAD_gamma PF04277.8 EFE41461.1 - 0.26 11.6 1.3 0.36 11.2 0.9 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Cnd1_N PF12922.2 EFE41461.1 - 0.31 10.6 2.3 0.36 10.4 1.6 1.1 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term SR-25 PF10500.4 EFE41461.1 - 0.45 9.9 14.1 0.55 9.6 9.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UPF0239 PF06783.6 EFE41461.1 - 0.54 10.2 7.7 0.78 9.6 5.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF3464 PF11947.3 EFE41461.1 - 1.2 8.5 4.5 1.6 8.1 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) YqfQ PF14181.1 EFE41461.1 - 1.2 9.1 7.4 1.6 8.7 5.2 1.1 1 0 0 1 1 1 0 YqfQ-like protein GAGA_bind PF06217.7 EFE41461.1 - 4 7.3 8.4 5.1 6.9 5.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2457 PF10446.4 EFE41462.1 - 3.9e-143 477.5 37.4 3.9e-143 477.5 25.9 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2457) CDC45 PF02724.9 EFE41462.1 - 0.043 11.8 32.9 0.32 8.9 17.4 2.2 2 0 0 2 2 2 0 CDC45-like protein Arf PF00025.16 EFE41464.1 - 1.8e-59 199.9 0.0 5.2e-59 198.3 0.0 1.6 1 1 1 2 2 2 1 ADP-ribosylation factor family G-alpha PF00503.15 EFE41464.1 - 4.3e-09 35.5 0.1 1.3e-05 24.0 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 EFE41464.1 - 2.3e-08 33.4 0.0 3.1e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 EFE41464.1 - 5.2e-07 30.1 0.0 7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFE41464.1 - 2.1e-06 27.6 0.0 3e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 EFE41464.1 - 0.00019 20.8 0.0 0.00023 20.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 EFE41464.1 - 0.0018 17.4 0.0 0.002 17.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 EFE41464.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.22 EFE41464.1 - 0.17 11.3 0.1 6.7 6.1 0.0 2.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Metallophos PF00149.23 EFE41465.1 - 6e-38 130.2 0.1 7.8e-38 129.8 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4614 PF15391.1 EFE41466.1 - 0.45 10.2 5.3 0.55 9.9 3.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Sigma70_ner PF04546.8 EFE41466.1 - 0.53 9.8 11.1 0.56 9.7 7.7 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region RNA_polI_A34 PF08208.6 EFE41466.1 - 1.1 8.8 18.8 1.1 8.8 13.0 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3381 PF11861.3 EFE41466.1 - 1.7 8.1 18.2 1.7 8.1 12.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) FAM176 PF14851.1 EFE41466.1 - 3 7.5 9.1 3.7 7.2 6.3 1.2 1 0 0 1 1 1 0 FAM176 family YqfQ PF14181.1 EFE41466.1 - 3.2 7.7 15.1 3.4 7.6 10.5 1.0 1 0 0 1 1 1 0 YqfQ-like protein Myc_N PF01056.13 EFE41466.1 - 3.8 6.5 11.9 3.8 6.5 8.2 1.0 1 0 0 1 1 1 0 Myc amino-terminal region TRAP_alpha PF03896.11 EFE41466.1 - 5.6 5.8 9.0 6.3 5.6 6.2 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Peptidase_C37 PF05416.7 EFE41466.1 - 6.8 4.8 7.3 6.7 4.8 5.1 1.0 1 0 0 1 1 1 0 Southampton virus-type processing peptidase DUF1510 PF07423.6 EFE41466.1 - 6.9 5.9 17.9 7.4 5.8 12.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Trypan_PARP PF05887.6 EFE41466.1 - 9 6.1 11.0 10 5.9 7.7 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) LRR_4 PF12799.2 EFE41467.1 - 5.6e-19 67.3 6.1 6.5e-07 28.8 0.7 5.8 4 1 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EFE41467.1 - 1.1e-11 43.0 10.3 0.78 10.0 0.1 7.4 6 1 1 7 7 7 5 Leucine Rich Repeat LRR_8 PF13855.1 EFE41467.1 - 1.3e-10 40.8 13.8 2.9e-07 30.1 1.8 4.1 3 1 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 EFE41467.1 - 4.2e-06 26.2 9.4 9.7 6.6 0.0 6.2 5 1 1 6 6 6 3 Leucine Rich repeat LRR_7 PF13504.1 EFE41467.1 - 0.00012 21.7 9.9 17 6.1 0.1 6.8 7 0 0 7 7 7 1 Leucine rich repeat SelP_N PF04592.9 EFE41467.1 - 6.9 5.9 46.7 1 8.7 5.1 3.3 3 0 0 3 3 3 0 Selenoprotein P, N terminal region DUF3336 PF11815.3 EFE41470.1 - 9.3e-46 154.9 2.5 1.4e-45 154.3 1.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EFE41470.1 - 2e-21 76.9 0.8 5.5e-21 75.4 0.0 2.2 2 0 0 2 2 2 1 Patatin-like phospholipase DUF1690 PF07956.6 EFE41470.1 - 0.042 13.8 0.2 0.097 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) TPR_11 PF13414.1 EFE41471.1 - 1.4e-23 82.2 18.4 9.7e-06 25.1 0.3 6.7 4 1 2 6 6 6 5 TPR repeat TPR_19 PF14559.1 EFE41471.1 - 9.2e-16 57.9 11.8 0.0026 18.0 0.1 7.4 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.1 EFE41471.1 - 2.6e-14 52.1 10.6 0.044 14.0 0.0 8.2 9 0 0 9 9 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE41471.1 - 1.8e-10 40.5 10.9 1 10.2 0.0 8.8 4 2 5 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFE41471.1 - 1.4e-09 38.3 18.1 0.00013 22.5 0.3 7.9 8 1 1 9 9 7 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFE41471.1 - 1.4e-08 34.5 19.9 0.097 12.6 0.0 7.3 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.1 EFE41471.1 - 2.8e-08 32.9 14.0 0.12 12.1 0.1 8.0 7 2 1 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFE41471.1 - 3.9e-08 32.6 23.2 0.085 12.8 0.3 9.3 9 0 0 9 9 9 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE41471.1 - 5.7e-08 32.7 17.9 0.0014 18.7 1.2 5.8 7 0 0 7 7 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 EFE41471.1 - 1.9e-05 24.0 27.1 0.57 9.8 0.0 8.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.1 EFE41471.1 - 0.0022 17.7 5.1 0.14 12.0 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE41471.1 - 0.0082 15.8 11.3 4.2 7.3 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFE41471.1 - 0.011 15.6 5.2 1.1 9.2 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFE41471.1 - 0.019 15.3 3.9 0.98 10.0 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 EFE41471.1 - 0.019 15.1 0.7 0.44 10.7 0.0 3.1 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_20 PF14561.1 EFE41471.1 - 0.023 14.7 1.9 3.8 7.6 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.12 EFE41471.1 - 0.059 13.6 0.5 0.47 10.7 0.0 2.3 1 1 0 2 2 2 0 Bacterial transcriptional activator domain ChAPs PF09295.5 EFE41471.1 - 0.059 12.1 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.4 EFE41471.1 - 0.17 11.2 1.7 6.5 6.0 0.2 3.1 3 0 0 3 3 3 0 26S proteasome subunit RPN7 ADH_N PF08240.7 EFE41472.1 - 6.1e-23 80.6 0.5 9.8e-23 80.0 0.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFE41472.1 - 5.8e-13 48.5 0.0 9.6e-13 47.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EFE41472.1 - 0.015 14.4 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EFE41472.1 - 0.16 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF4241 PF14025.1 EFE41472.1 - 0.17 11.6 0.1 0.41 10.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) Nucleopor_Nup85 PF07575.8 EFE41474.1 - 1.3e-16 59.9 1.2 9.6e-10 37.2 0.0 2.9 2 1 0 2 2 2 2 Nup85 Nucleoporin TIG PF01833.19 EFE41475.1 - 0.019 14.9 1.5 0.019 14.9 1.1 2.3 2 0 0 2 2 2 0 IPT/TIG domain Trp_syntA PF00290.15 EFE41476.1 - 2.8e-88 294.8 0.0 4.6e-88 294.0 0.0 1.3 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 EFE41476.1 - 3.2e-43 148.1 1.5 6.6e-43 147.0 1.1 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Adeno_E3_CR2 PF02439.10 EFE41477.1 - 0.033 13.7 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rubella_E2 PF05749.6 EFE41477.1 - 0.046 12.9 3.1 0.062 12.5 2.2 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 DUF508 PF04370.7 EFE41477.1 - 0.12 12.0 0.3 0.2 11.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF508) ATP-synt_ab PF00006.20 EFE41478.1 - 1e-61 208.2 0.0 1.3e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EFE41478.1 - 1.5e-17 64.0 0.0 2.8e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain Peptidase_S10 PF00450.17 EFE41479.1 - 8.8e-72 242.5 0.1 2.5e-71 241.0 0.1 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 EFE41479.1 - 0.0067 16.3 0.0 0.04 13.7 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family F-box PF00646.28 EFE41480.1 - 0.0022 17.5 0.1 0.0051 16.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain Usp PF00582.21 EFE41481.1 - 3.8e-20 72.4 0.8 2.2e-13 50.5 0.3 2.8 2 0 0 2 2 2 2 Universal stress protein family DnaJ PF00226.26 EFE41482.1 - 2.2e-22 78.5 2.2 2.2e-22 78.5 1.5 2.4 3 0 0 3 3 3 1 DnaJ domain DUF4598 PF15370.1 EFE41482.1 - 3.5 7.9 7.0 2.1 8.6 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4598) Pkinase PF00069.20 EFE41485.1 - 6.4e-63 212.3 0.2 4.7e-62 209.4 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41485.1 - 1.7e-32 112.4 0.5 1.3e-31 109.6 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EFE41485.1 - 0.08 11.7 0.8 0.096 11.4 0.0 1.4 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase LIM_bind PF01803.11 EFE41486.1 - 1.7e-70 236.8 0.0 1.7e-70 236.8 0.0 3.9 2 1 1 4 4 4 1 LIM-domain binding protein cobW PF02492.14 EFE41487.1 - 7.7e-27 93.8 0.0 9e-27 93.6 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 EFE41487.1 - 0.0024 16.7 0.1 0.0029 16.4 0.1 1.1 1 0 0 1 1 1 1 ArgK protein BING4CT PF08149.6 EFE41488.1 - 2.8e-40 135.6 0.0 2.1e-37 126.4 0.0 2.7 2 0 0 2 2 2 2 BING4CT (NUC141) domain WD40 PF00400.27 EFE41488.1 - 2.5e-06 27.1 0.0 0.01 15.6 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF4427 PF14468.1 EFE41488.1 - 0.0076 15.9 0.6 0.024 14.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4427) DUF663 PF04950.7 EFE41489.1 - 3e-96 321.8 0.0 5.4e-96 321.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 EFE41489.1 - 1.8e-25 88.2 0.0 4.2e-25 87.1 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain HlyIII PF03006.15 EFE41490.1 - 1.7e-23 83.2 9.6 2.1e-23 82.8 6.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF726 PF05277.7 EFE41491.1 - 4.8e-116 387.4 0.4 7.3e-116 386.8 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.2 EFE41491.1 - 0.00056 19.8 3.0 0.0006 19.7 0.0 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EFE41491.1 - 0.025 14.8 0.1 0.079 13.1 0.0 1.8 2 0 0 2 2 2 0 Thioesterase domain Abhydrolase_1 PF00561.15 EFE41491.1 - 0.042 13.3 0.0 0.087 12.3 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold TcdA_TcdB_pore PF12920.2 EFE41491.1 - 0.17 9.7 2.7 0.26 9.1 1.9 1.2 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain Abhydrolase_5 PF12695.2 EFE41491.1 - 0.18 11.5 0.0 0.18 11.5 0.0 2.5 2 1 1 3 3 3 0 Alpha/beta hydrolase family Glu-tRNAGln PF02686.10 EFE41492.1 - 2e-05 24.2 0.4 0.0002 21.0 0.2 2.2 2 0 0 2 2 2 1 Glu-tRNAGln amidotransferase C subunit DUF2390 PF09523.5 EFE41492.1 - 0.12 12.5 1.1 0.78 9.9 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2390) DUF3521 PF12035.3 EFE41492.1 - 0.41 10.5 1.9 0.53 10.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3521) SNAP PF14938.1 EFE41493.1 - 2.9e-111 371.1 19.8 3.3e-111 370.9 13.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 EFE41493.1 - 4.2e-10 39.4 10.9 7.2e-05 22.6 2.9 2.7 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFE41493.1 - 1.4e-05 24.6 11.8 0.48 10.4 0.1 6.1 3 1 2 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE41493.1 - 0.00095 19.7 13.2 0.0099 16.5 1.7 3.6 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 EFE41493.1 - 0.0015 18.1 12.5 0.3 10.7 1.1 3.7 1 1 3 4 4 4 4 TPR repeat TPR_7 PF13176.1 EFE41493.1 - 0.0064 16.2 6.7 14 5.8 0.2 5.7 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE41493.1 - 0.0082 16.4 7.7 0.22 11.8 0.6 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFE41493.1 - 0.045 14.2 14.3 3.3 8.3 0.1 5.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE41493.1 - 0.045 14.3 11.8 4.6 8.1 0.8 5.1 1 1 4 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFE41493.1 - 0.06 13.1 13.9 0.32 10.8 0.2 5.5 4 1 1 6 6 5 0 Tetratricopeptide repeat NSF PF02071.15 EFE41493.1 - 0.14 12.7 0.4 0.14 12.7 0.3 6.1 6 0 0 6 6 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.23 EFE41493.1 - 0.3 10.7 16.1 2.5 7.8 0.7 5.3 4 1 1 5 5 5 0 Tetratricopeptide repeat Ank_2 PF12796.2 EFE41494.1 - 7.8e-09 35.7 0.2 2.7e-07 30.8 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EFE41494.1 - 1.4e-05 24.8 0.4 1.6 9.1 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.25 EFE41494.1 - 3.6e-05 23.3 0.5 0.055 13.2 0.0 3.3 2 1 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 EFE41494.1 - 0.00098 19.5 0.0 0.064 13.8 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) ClpB_D2-small PF10431.4 EFE41494.1 - 0.02 14.7 0.0 0.054 13.4 0.0 1.6 1 0 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.1 EFE41494.1 - 0.044 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 EFE41494.1 - 0.11 13.3 0.1 0.37 11.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain DUF3632 PF12311.3 EFE41495.1 - 1.7e-43 148.5 0.8 2.6e-43 147.9 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) GPI-anchored PF10342.4 EFE41497.1 - 2.4e-09 37.5 9.2 9.5e-09 35.6 0.1 3.2 2 2 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SMN PF06003.7 EFE41498.1 - 0.54 9.3 3.0 0.2 10.7 0.5 1.4 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) CBF PF03914.12 EFE41500.1 - 3.6e-46 156.6 0.2 7.9e-46 155.5 0.1 1.6 1 0 0 1 1 1 1 CBF/Mak21 family HNH PF01844.18 EFE41500.1 - 0.18 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 HNH endonuclease DUF727 PF05303.7 EFE41500.1 - 0.88 9.3 3.2 4.5 7.1 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF727) Mt_ATP-synt_B PF05405.9 EFE41501.1 - 2.7e-50 169.9 9.6 3.3e-50 169.7 6.6 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF1539 PF07560.6 EFE41501.1 - 0.053 13.3 0.4 0.078 12.8 0.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) Mito_morph_reg PF14972.1 EFE41501.1 - 0.13 11.6 0.6 0.33 10.3 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial morphogenesis regulator PBP_sp32 PF07222.7 EFE41501.1 - 0.25 10.4 6.6 0.37 9.9 4.6 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Pkinase PF00069.20 EFE41502.1 - 4.8e-23 81.6 0.0 6.6e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41502.1 - 9e-09 34.7 0.0 0.00079 18.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DUF3253 PF11625.3 EFE41502.1 - 0.038 13.8 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3253) Sel1 PF08238.7 EFE41504.1 - 7.2e-15 55.0 6.5 7.5e-08 32.7 1.0 3.7 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 EFE41504.1 - 0.012 16.0 1.8 0.25 11.8 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFE41504.1 - 0.083 13.5 0.4 0.33 11.6 0.2 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat VPS9 PF02204.13 EFE41505.1 - 3.3e-26 91.3 0.0 5.7e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain GIDA PF01134.17 EFE41505.1 - 0.023 13.5 0.4 0.076 11.8 0.3 1.7 1 1 0 1 1 1 0 Glucose inhibited division protein A Lipase_3 PF01764.20 EFE41506.1 - 5.4e-06 26.0 0.0 9.9e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EFE41506.1 - 0.0057 16.4 0.0 0.016 14.9 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family UPF0227 PF05728.7 EFE41506.1 - 0.042 13.5 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) MDM31_MDM32 PF08118.6 EFE41508.1 - 6e-189 628.6 3.7 1.2e-187 624.4 2.5 2.0 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins KH_1 PF00013.24 EFE41509.1 - 0.00035 20.1 1.2 0.0007 19.1 0.8 1.5 1 0 0 1 1 1 1 KH domain Proteasome PF00227.21 EFE41510.1 - 6.4e-32 110.3 0.0 1.5e-31 109.2 0.1 1.5 2 1 0 2 2 2 1 Proteasome subunit HCNGP PF07818.8 EFE41511.1 - 1.4e-33 114.7 0.4 2.8e-33 113.8 0.3 1.5 1 0 0 1 1 1 1 HCNGP-like protein Ketoacyl-synt_C PF02801.17 EFE41511.1 - 0.021 14.6 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Proteasome PF00227.21 EFE41512.1 - 2.4e-16 59.5 0.0 2.9e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit FAA_hydrolase PF01557.13 EFE41513.1 - 7.4e-61 205.3 0.0 9e-61 205.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family HSP20 PF00011.16 EFE41514.1 - 4.5e-18 65.0 0.2 1.4e-12 47.3 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family TPP1 PF10341.4 EFE41514.1 - 0.031 14.2 0.0 0.093 12.7 0.0 1.8 1 0 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD SOG2 PF10428.4 EFE41514.1 - 0.066 11.8 1.9 0.074 11.6 1.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Mif2_N PF15624.1 EFE41514.1 - 0.07 13.7 3.8 0.12 12.9 2.6 1.3 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal FAM104 PF15434.1 EFE41516.1 - 0.38 10.9 2.2 0.58 10.3 1.5 1.5 1 1 0 1 1 1 0 Family 104 Bac_rhodopsin PF01036.13 EFE41517.1 - 2.8e-36 124.9 21.9 3.1e-36 124.7 15.1 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF4282 PF14110.1 EFE41517.1 - 0.017 15.3 0.6 0.017 15.3 0.4 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4282) MFS_1 PF07690.11 EFE41519.1 - 5.7e-30 104.2 59.3 2.8e-28 98.6 28.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE41519.1 - 1.1e-08 34.1 41.7 1.2e-06 27.4 6.9 2.8 2 1 1 3 3 3 2 Sugar (and other) transporter Sulfatase PF00884.18 EFE41521.1 - 7.9e-79 265.0 0.0 9.7e-79 264.7 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.12 EFE41521.1 - 1.4e-05 23.7 0.0 2.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.17 EFE41521.1 - 0.042 13.1 0.0 0.074 12.3 0.0 1.4 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.1 EFE41521.1 - 0.13 12.5 0.1 4.2 7.6 0.0 2.4 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase Metalloenzyme PF01676.13 EFE41521.1 - 0.14 11.5 0.0 1.5 8.1 0.0 2.4 2 1 0 2 2 2 0 Metalloenzyme superfamily Cytomega_UL84 PF06284.6 EFE41522.1 - 0.031 12.7 0.2 0.036 12.5 0.1 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF2360 PF10152.4 EFE41523.1 - 0.3 11.3 3.0 0.29 11.3 2.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) WD40 PF00400.27 EFE41524.1 - 4.4e-23 80.2 9.9 7.5e-08 31.9 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat Rax2 PF12768.2 EFE41524.1 - 0.012 14.8 0.8 0.048 12.8 0.0 2.1 3 0 0 3 3 3 0 Cortical protein marker for cell polarity Lipase_3 PF01764.20 EFE41525.1 - 7.4e-31 106.6 0.0 1.1e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.15 EFE41525.1 - 0.00026 20.5 0.0 0.00044 19.7 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DUF2974 PF11187.3 EFE41525.1 - 0.062 12.6 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) GHMP_kinases_C PF08544.8 EFE41525.1 - 0.07 13.3 0.0 0.26 11.5 0.0 1.9 2 0 0 2 2 2 0 GHMP kinases C terminal Abhydrolase_5 PF12695.2 EFE41525.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family WW PF00397.21 EFE41526.1 - 5.4e-09 35.7 0.6 1.4e-08 34.4 0.4 1.8 1 0 0 1 1 1 1 WW domain Fungal_trans_2 PF11951.3 EFE41527.1 - 2.5e-23 82.3 1.3 2.2e-22 79.2 0.9 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Ecm29 PF13001.2 EFE41528.1 - 2e-151 504.8 0.0 8e-150 499.6 0.0 3.1 3 1 0 3 3 3 1 Proteasome stabiliser HEAT_2 PF13646.1 EFE41528.1 - 4.5e-08 33.2 6.4 1.1 9.6 0.1 7.1 6 1 1 7 7 7 3 HEAT repeats HEAT PF02985.17 EFE41528.1 - 1.3e-06 27.9 1.4 1.3 9.3 0.0 8.8 12 0 0 12 12 12 1 HEAT repeat HEAT_EZ PF13513.1 EFE41528.1 - 0.0033 17.8 8.6 0.34 11.4 0.0 7.5 9 0 0 9 9 9 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFE41528.1 - 0.012 15.9 1.9 0.24 11.7 0.1 4.2 4 1 0 4 4 4 0 Vacuolar 14 Fab1-binding region Helicase_C PF00271.26 EFE41529.1 - 5.1e-05 23.0 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFE41530.1 - 1.1e-55 188.5 0.5 4.8e-55 186.4 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.10 EFE41530.1 - 0.0053 16.6 0.0 0.019 14.7 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ESPR PF13018.1 EFE41531.1 - 0.18 11.4 0.4 0.32 10.6 0.3 1.5 1 0 0 1 1 1 0 Extended Signal Peptide of Type V secretion system DUF940 PF06082.6 EFE41531.1 - 2.5 6.5 6.3 2.4 6.5 4.4 1.0 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) Frag1 PF10277.4 EFE41533.1 - 1.1e-17 64.2 7.0 1.3e-17 64.0 4.8 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF4436 PF14494.1 EFE41533.1 - 0.013 14.8 1.7 0.019 14.2 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) DUF3995 PF13160.1 EFE41533.1 - 0.074 13.1 2.2 0.09 12.8 0.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3995) BPD_transp_2 PF02653.11 EFE41533.1 - 0.078 11.9 2.2 0.088 11.7 1.5 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component DUF1980 PF09323.5 EFE41533.1 - 0.093 12.4 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) KdpA PF03814.10 EFE41533.1 - 0.31 8.9 3.4 0.36 8.7 1.9 1.4 1 1 0 1 1 1 0 Potassium-transporting ATPase A subunit Herpes_LMP1 PF05297.6 EFE41533.1 - 0.96 8.3 3.0 1.3 7.9 2.1 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF998 PF06197.8 EFE41533.1 - 1.3 8.2 6.4 2.1 7.5 4.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF998) PRA1 PF03208.14 EFE41534.1 - 1.6e-32 111.9 0.1 2.4e-32 111.4 0.1 1.2 1 0 0 1 1 1 1 PRA1 family protein Sarcoglycan_1 PF04790.8 EFE41534.1 - 0.33 10.0 1.1 0.52 9.4 0.7 1.2 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein MCM PF00493.18 EFE41535.1 - 1.6e-120 401.9 0.0 2.4e-120 401.3 0.0 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM2_N PF12619.3 EFE41535.1 - 2.4e-30 105.6 31.4 2.4e-30 105.6 21.8 2.3 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 EFE41535.1 - 3.8e-18 66.1 0.1 9.4e-18 64.8 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 EFE41535.1 - 1.1e-07 31.2 0.1 7.6e-06 25.2 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFE41535.1 - 6.7e-06 25.8 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EFE41535.1 - 0.00045 19.8 0.0 0.0047 16.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFE41535.1 - 0.0041 16.5 0.2 0.078 12.4 0.1 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain zf-UBR PF02207.15 EFE41536.1 - 1.4e-16 59.9 3.9 1.4e-16 59.9 2.7 3.6 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) Sugar_tr PF00083.19 EFE41537.1 - 2.6e-26 92.2 21.6 4.1e-21 75.0 4.8 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE41537.1 - 1.7e-15 56.6 37.6 2.3e-14 52.8 21.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PEPCK_ATP PF01293.15 EFE41538.1 - 1.6e-216 719.3 0.0 2e-216 718.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 EFE41538.1 - 0.1 12.4 0.1 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EFE41538.1 - 0.17 11.8 0.0 0.39 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Aminotran_1_2 PF00155.16 EFE41539.1 - 3.8e-39 134.6 0.0 5.1e-39 134.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II RPN7 PF10602.4 EFE41540.1 - 6.6e-54 181.9 0.5 6.6e-54 181.9 0.3 1.6 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 EFE41540.1 - 1.2e-11 44.8 0.0 2.3e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.1 EFE41540.1 - 0.063 13.1 2.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MIS13 PF08202.6 EFE41541.1 - 2.6e-29 102.2 10.0 2.6e-29 102.2 6.9 3.5 2 1 0 2 2 2 1 Mis12-Mtw1 protein family DivIC PF04977.10 EFE41541.1 - 0.021 14.3 0.1 0.056 12.9 0.0 1.7 1 0 0 1 1 1 0 Septum formation initiator Sugar_tr PF00083.19 EFE41542.1 - 2.7e-76 256.9 28.4 1.2e-75 254.8 19.7 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE41542.1 - 6e-31 107.4 47.2 9.3e-20 70.6 15.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE41542.1 - 0.0015 17.0 2.5 0.0015 17.0 1.7 4.2 2 2 2 4 4 4 3 MFS/sugar transport protein AMP-binding PF00501.23 EFE41543.1 - 1.5e-78 264.0 0.0 2.4e-78 263.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.21 EFE41543.1 - 2.7e-62 210.5 0.1 2.6e-61 207.3 0.0 2.4 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 EFE41543.1 - 1.8e-51 174.3 0.0 5.5e-50 169.5 0.0 2.4 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.16 EFE41543.1 - 1.8e-46 158.9 0.0 3.6e-46 157.9 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 EFE41543.1 - 2.8e-46 158.0 0.0 4.3e-46 157.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Condensation PF00668.15 EFE41543.1 - 6.8e-42 143.3 0.0 1e-41 142.7 0.0 1.2 1 0 0 1 1 1 1 Condensation domain adh_short PF00106.20 EFE41543.1 - 7.6e-41 139.8 0.0 1.3e-38 132.5 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFE41543.1 - 1.1e-31 109.1 0.0 4e-31 107.3 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.7 EFE41543.1 - 2.5e-19 69.1 0.0 5.6e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein Methyltransf_12 PF08242.7 EFE41543.1 - 3.6e-19 69.0 0.0 2.2e-17 63.3 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.20 EFE41543.1 - 3.3e-15 56.0 2.6 6.2e-08 32.7 0.1 3.0 3 0 0 3 3 2 2 Phosphopantetheine attachment site HxxPF_rpt PF13745.1 EFE41543.1 - 3.7e-11 43.1 0.0 1e-10 41.8 0.0 1.8 1 0 0 1 1 1 1 HxxPF-repeated domain Methyltransf_23 PF13489.1 EFE41543.1 - 1.2e-10 41.3 0.0 3.5e-10 39.8 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE41543.1 - 4.6e-10 40.0 0.0 3.2e-09 37.3 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE41543.1 - 9.4e-10 38.8 0.0 5.7e-09 36.3 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE41543.1 - 2.4e-08 33.6 0.0 5.1e-07 29.4 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Thiolase_N PF00108.18 EFE41543.1 - 2.8e-06 26.4 0.1 5.8e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.13 EFE41543.1 - 3.1e-06 26.4 0.0 1.2e-05 24.5 0.0 2.0 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family Epimerase PF01370.16 EFE41543.1 - 0.00022 20.7 0.0 0.036 13.5 0.0 2.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Methyltransf_16 PF10294.4 EFE41543.1 - 0.01 15.3 0.0 0.025 14.0 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase RrnaAD PF00398.15 EFE41543.1 - 0.14 11.1 0.0 0.41 9.6 0.0 1.7 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Post_transc_reg PF13797.1 EFE41543.1 - 0.24 11.0 0.0 0.54 9.8 0.0 1.5 1 0 0 1 1 1 0 Post-transcriptional regulator AATase PF07247.7 EFE41543.1 - 0.3 9.6 0.0 0.57 8.6 0.0 1.3 1 0 0 1 1 1 0 Alcohol acetyltransferase UvdE PF03851.9 EFE41544.1 - 3.7e-110 367.3 0.0 4.6e-110 366.9 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE Como_LCP PF02247.11 EFE41544.1 - 0.17 10.2 0.0 0.24 9.7 0.0 1.1 1 0 0 1 1 1 0 Large coat protein ADH_zinc_N PF00107.21 EFE41546.1 - 3e-11 42.9 0.0 5.5e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE41546.1 - 3.8e-07 29.8 2.2 1e-06 28.4 1.3 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Pkinase PF00069.20 EFE41548.1 - 4e-56 190.0 0.0 5.1e-56 189.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41548.1 - 5.3e-26 91.2 0.0 8.2e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase GFO_IDH_MocA PF01408.17 EFE41549.1 - 3.2e-10 40.5 0.5 1.6e-09 38.3 0.4 2.1 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DHDPS PF00701.17 EFE41550.1 - 4.3e-35 120.7 0.0 1.6e-33 115.5 0.0 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family ADH_zinc_N PF00107.21 EFE41551.1 - 6.4e-16 58.0 0.0 1.4e-15 56.9 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE41551.1 - 7.9e-13 48.1 0.6 1.6e-12 47.1 0.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.14 EFE41551.1 - 9.7e-05 21.5 0.2 0.00017 20.7 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 EFE41551.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA WD40 PF00400.27 EFE41552.1 - 4.9e-38 127.6 7.7 2.4e-08 33.5 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat F-box-like PF12937.2 EFE41552.1 - 1.1e-09 37.8 0.1 2.5e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE41552.1 - 1.3e-05 24.6 0.1 2.7e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 F-box domain PQQ PF01011.16 EFE41552.1 - 0.00038 19.8 0.0 3.1 7.5 0.0 3.5 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_2 PF13360.1 EFE41552.1 - 0.00055 19.4 0.2 0.0036 16.7 0.1 2.1 1 1 0 1 1 1 1 PQQ-like domain ADH_zinc_N_2 PF13602.1 EFE41553.1 - 1.5e-12 48.5 0.0 2.3e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFE41553.1 - 5.2e-11 42.2 0.0 8.3e-11 41.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase EB1 PF03271.12 EFE41554.1 - 6.9e-17 61.2 0.2 1.1e-16 60.5 0.1 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif Herpes_UL6 PF01763.11 EFE41554.1 - 0.0027 15.9 0.0 0.0031 15.7 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL6 like DUF1191 PF06697.7 EFE41555.1 - 0.0016 17.3 0.0 0.0028 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) Adeno_E3_CR2 PF02439.10 EFE41555.1 - 0.088 12.3 0.5 0.17 11.4 0.3 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SKG6 PF08693.5 EFE41555.1 - 1.5 8.2 5.4 0.48 9.7 1.3 2.1 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Glutaredoxin PF00462.19 EFE41558.1 - 1.4e-08 34.6 0.0 1.8e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Chalcone PF02431.10 EFE41559.1 - 2.3e-63 213.1 0.0 3e-63 212.8 0.0 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase GTP_EFTU PF00009.22 EFE41560.1 - 2.9e-57 193.1 0.0 4.4e-57 192.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EFE41560.1 - 7.7e-37 125.4 0.0 2.2e-36 124.0 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFE41560.1 - 6.8e-17 61.3 1.7 2.1e-16 59.7 1.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 EFE41560.1 - 2.8e-05 23.6 0.4 2.8e-05 23.6 0.3 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 EFE41560.1 - 0.0018 18.2 0.3 0.005 16.7 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase NAD_binding_10 PF13460.1 EFE41561.1 - 1.2e-09 38.4 0.0 1.7e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFE41561.1 - 2.5e-07 30.1 0.0 8.9e-07 28.3 0.0 1.8 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 EFE41561.1 - 0.048 12.5 0.0 0.089 11.6 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Epimerase PF01370.16 EFE41561.1 - 0.071 12.5 0.0 0.48 9.8 0.0 2.2 3 0 0 3 3 3 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 EFE41561.1 - 0.081 12.9 0.0 0.2 11.6 0.0 1.7 1 1 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.12 EFE41561.1 - 0.15 12.4 0.0 0.97 9.9 0.0 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent PH_4 PF15404.1 EFE41562.1 - 1.6e-44 151.6 0.9 1.1e-43 148.9 0.1 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.1 EFE41562.1 - 1.1e-14 53.6 0.0 4.2e-14 51.7 0.0 2.0 1 1 0 1 1 1 1 Sporulation protein family 7 PH PF00169.24 EFE41562.1 - 1.2e-06 28.6 0.6 0.0041 17.2 0.0 3.7 3 1 0 3 3 3 2 PH domain PH_6 PF15406.1 EFE41562.1 - 0.0018 18.2 0.2 0.21 11.6 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.1 EFE41562.1 - 0.0024 18.0 0.1 0.032 14.3 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain Spt5_N PF11942.3 EFE41562.1 - 2.3 8.8 14.2 1.5 9.5 4.2 3.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal GLTP PF08718.6 EFE41563.1 - 1.4e-45 155.0 0.1 1.8e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) AA_permease_2 PF13520.1 EFE41564.1 - 5.6e-61 206.3 50.4 6.9e-61 206.0 35.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE41564.1 - 2.2e-22 79.0 39.6 3.4e-22 78.4 27.5 1.2 1 0 0 1 1 1 1 Amino acid permease E1-E2_ATPase PF00122.15 EFE41566.1 - 4.4e-23 81.5 0.0 2.1e-22 79.3 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EFE41566.1 - 4.5e-21 76.2 0.0 2.8e-20 73.6 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFE41566.1 - 1.3e-18 67.9 0.0 2.5e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE41566.1 - 0.0003 20.6 0.0 0.00075 19.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFE41566.1 - 0.00035 20.2 0.2 0.0037 16.8 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 EFE41566.1 - 0.059 12.6 0.1 0.21 10.8 0.0 1.8 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase FYVE PF01363.16 EFE41567.1 - 8.9e-20 70.3 13.5 1.2e-14 53.9 1.9 2.9 3 0 0 3 3 3 2 FYVE zinc finger Seryl_tRNA_N PF02403.17 EFE41567.1 - 0.03 14.3 1.4 0.1 12.6 1.0 1.9 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain zf-AN1 PF01428.11 EFE41567.1 - 0.051 13.4 19.9 0.052 13.4 4.6 3.1 2 1 1 3 3 3 0 AN1-like Zinc finger TMF_TATA_bd PF12325.3 EFE41567.1 - 0.15 11.8 1.1 0.29 10.8 0.1 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding FYVE_2 PF02318.11 EFE41567.1 - 0.86 9.5 12.1 0.078 12.8 1.8 3.1 3 0 0 3 3 3 0 FYVE-type zinc finger IBR PF01485.16 EFE41567.1 - 1.1 9.2 17.0 0.048 13.5 2.4 2.9 3 0 0 3 3 3 0 IBR domain C6_DPF PF10170.4 EFE41567.1 - 1.2 9.2 7.3 0.2 11.7 0.8 2.4 2 0 0 2 2 2 0 Cysteine-rich domain zf-C2HC5 PF06221.8 EFE41567.1 - 1.4 8.6 16.4 1.2 8.9 0.7 3.5 2 1 1 3 3 3 0 Putative zinc finger motif, C2HC5-type zf-Di19 PF05605.7 EFE41567.1 - 4.1 7.6 13.1 20 5.3 0.0 3.3 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Transp_Tc5_C PF04236.10 EFE41567.1 - 6.4 7.0 10.4 0.2 11.9 1.8 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain PKD_channel PF08016.7 EFE41568.1 - 4e-08 32.1 16.8 1.7e-06 26.7 11.6 2.5 1 1 0 1 1 1 1 Polycystin cation channel DUF3782 PF12644.2 EFE41568.1 - 0.14 11.9 0.1 0.61 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3782) CAML PF14963.1 EFE41568.1 - 2.4 7.4 10.8 0.16 11.2 3.3 2.0 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand EIF_2_alpha PF07541.7 EFE41569.1 - 1.4e-37 127.8 0.0 3.7e-37 126.5 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 EFE41569.1 - 3e-13 49.6 0.9 5.9e-13 48.7 0.6 1.5 1 0 0 1 1 1 1 S1 RNA binding domain SPOC PF07744.8 EFE41569.1 - 0.025 15.0 0.1 0.11 13.0 0.0 2.0 2 0 0 2 2 2 0 SPOC domain MscS_TM PF12794.2 EFE41569.1 - 0.091 11.3 0.0 0.13 10.8 0.0 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Sulfate_transp PF00916.15 EFE41570.1 - 8.9e-50 169.2 6.9 1.1e-49 168.9 4.2 1.6 1 1 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 EFE41570.1 - 3.9e-28 96.9 2.9 3.9e-28 96.9 2.0 2.3 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EFE41570.1 - 3.9e-16 58.5 0.0 6.5e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 EFE41570.1 - 0.0022 17.9 0.0 0.0057 16.6 0.0 1.8 1 1 0 1 1 1 1 STAS domain CENP-L PF13092.1 EFE41571.1 - 5.4e-62 208.3 0.0 7e-62 207.9 0.0 1.1 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 DUF3638 PF12340.3 EFE41572.1 - 1.2e-103 345.0 0.1 1.9e-103 344.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 EFE41572.1 - 1.2e-14 53.1 0.0 5e-14 51.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) ABC_membrane PF00664.18 EFE41573.1 - 2.8e-35 122.0 12.9 3.7e-35 121.6 8.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 EFE41573.1 - 4.5e-34 117.6 0.0 8.5e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EFE41573.1 - 2.1e-07 31.2 0.0 0.0026 17.7 0.0 2.7 2 1 1 3 3 2 2 AAA domain SMC_N PF02463.14 EFE41573.1 - 1.7e-05 24.1 0.0 0.0033 16.6 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EFE41573.1 - 0.00016 22.4 0.1 0.00042 21.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE41573.1 - 0.00021 21.3 0.1 0.00085 19.3 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFE41573.1 - 0.00042 20.4 0.0 0.0028 17.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFE41573.1 - 0.0014 18.5 0.0 0.025 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFE41573.1 - 0.0022 18.3 0.0 0.0057 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFE41573.1 - 0.0025 17.0 0.0 0.0054 15.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 EFE41573.1 - 0.0034 16.8 0.1 0.0094 15.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 EFE41573.1 - 0.016 15.1 0.0 0.15 12.0 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_10 PF12846.2 EFE41573.1 - 0.021 14.2 0.1 0.11 11.8 0.0 2.0 1 1 0 2 2 2 0 AAA-like domain AAA_28 PF13521.1 EFE41573.1 - 0.023 14.6 0.0 0.16 11.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 EFE41573.1 - 0.026 14.0 0.0 0.049 13.1 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain ABC_ATPase PF09818.4 EFE41573.1 - 0.035 12.6 0.0 0.32 9.5 0.0 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_23 PF13476.1 EFE41573.1 - 0.036 14.3 0.6 0.08 13.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA PF00004.24 EFE41573.1 - 0.04 14.1 0.0 0.33 11.1 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EFE41573.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EFE41573.1 - 0.078 12.0 0.0 0.41 9.7 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.10 EFE41573.1 - 0.08 11.6 0.0 0.13 10.8 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF2013 PF09431.5 EFE41574.1 - 5.2e-51 172.0 1.7 1.2e-50 170.8 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) Glyco_hydro_17 PF00332.13 EFE41575.1 - 8.9e-07 28.2 2.7 1.6e-05 24.1 0.2 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 17 Aminotran_1_2 PF00155.16 EFE41576.1 - 2.9e-34 118.6 0.0 3.6e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Glucan_synthase PF02364.10 EFE41577.1 - 0 1459.8 0.0 0 1459.2 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 EFE41577.1 - 2.7e-39 133.6 0.2 6.4e-39 132.5 0.2 1.7 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Pox_Ag35 PF03286.9 EFE41578.1 - 0.57 9.6 16.1 0.62 9.5 11.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Prothymosin PF03247.9 EFE41578.1 - 0.62 10.2 21.2 0.73 10.0 14.7 1.1 1 0 0 1 1 1 0 Prothymosin/parathymosin family NAD_binding_1 PF00175.16 EFE41578.1 - 0.74 10.4 2.7 0.89 10.1 1.9 1.2 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain PBP_sp32 PF07222.7 EFE41578.1 - 2.2 7.3 12.2 2.7 7.0 8.5 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 RNA_pol_Rpc4 PF05132.9 EFE41578.1 - 7.3 6.5 12.7 11 6.0 8.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF1510 PF07423.6 EFE41578.1 - 9.1 5.5 17.6 10 5.4 12.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Glyco_hydro_72 PF03198.9 EFE41580.1 - 1.8e-132 441.0 7.3 2.3e-132 440.7 5.0 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 EFE41580.1 - 1.1e-25 89.9 3.9 1.1e-25 89.9 2.7 2.2 2 0 0 2 2 2 1 X8 domain Glyco_hydro_2_C PF02836.12 EFE41580.1 - 7.6e-07 28.3 0.3 1.1e-06 27.7 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.13 EFE41580.1 - 0.00055 19.2 0.6 0.0071 15.5 0.4 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_cc PF11790.3 EFE41580.1 - 0.015 14.7 0.4 0.023 14.1 0.3 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core SprT-like PF10263.4 EFE41581.1 - 5.2e-46 156.1 0.4 9.7e-46 155.2 0.3 1.5 1 0 0 1 1 1 1 SprT-like family Peptidase_M30 PF10460.4 EFE41581.1 - 0.035 12.9 0.2 0.088 11.6 0.0 1.7 2 0 0 2 2 2 0 Peptidase M30 Mog1 PF04603.7 EFE41582.1 - 2.1e-11 43.9 0.5 6.3e-06 26.1 0.0 3.5 1 1 0 3 3 3 2 Ran-interacting Mog1 protein PAD_porph PF04371.10 EFE41582.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase NYN PF01936.13 EFE41583.1 - 0.00043 20.5 0.0 0.0046 17.2 0.0 2.3 1 1 0 1 1 1 1 NYN domain HSP9_HSP12 PF04119.7 EFE41584.1 - 2.1e-25 88.5 4.4 2.1e-25 88.5 3.1 1.9 2 0 0 2 2 2 1 Heat shock protein 9/12 Chlorosome_CsmC PF11098.3 EFE41584.1 - 0.038 13.6 0.1 0.047 13.3 0.1 1.1 1 0 0 1 1 1 0 Chlorosome envelope protein C COG6 PF06419.6 EFE41585.1 - 1.6e-223 743.4 0.4 1.8e-223 743.2 0.3 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Transcrip_act PF04949.8 EFE41585.1 - 0.0022 17.6 0.5 0.019 14.5 0.1 2.7 3 1 0 3 3 3 1 Transcriptional activator COG2 PF06148.6 EFE41585.1 - 0.0081 16.0 0.9 6.6 6.6 0.0 3.1 2 0 0 2 2 2 2 COG (conserved oligomeric Golgi) complex component, COG2 NIF3 PF01784.13 EFE41586.1 - 3.5e-28 98.8 0.0 2.3e-22 79.7 0.0 2.5 1 1 1 2 2 2 2 NIF3 (NGG1p interacting factor 3) Redoxin PF08534.5 EFE41588.1 - 3e-31 107.9 0.0 3.5e-31 107.6 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EFE41588.1 - 3.5e-09 36.3 0.0 4.4e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Raftlin PF15250.1 EFE41590.1 - 0.017 13.6 3.6 0.37 9.2 2.9 2.0 2 0 0 2 2 2 0 Raftlin NPR3 PF03666.8 EFE41590.1 - 0.049 12.1 7.3 0.065 11.7 5.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2828 PF11443.3 EFE41590.1 - 0.24 9.5 6.7 0.31 9.1 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ycf1 PF05758.7 EFE41590.1 - 0.3 8.7 13.6 0.48 8.0 9.4 1.2 1 0 0 1 1 1 0 Ycf1 Atrophin-1 PF03154.10 EFE41590.1 - 1.6 6.7 6.9 2.4 6.2 4.8 1.4 1 0 0 1 1 1 0 Atrophin-1 family HSF_DNA-bind PF00447.12 EFE41591.1 - 3.8e-09 36.6 0.0 1.3e-08 34.8 0.0 2.0 1 1 0 1 1 1 1 HSF-type DNA-binding FTO_CTD PF12934.2 EFE41591.1 - 0.018 14.5 0.3 0.045 13.3 0.0 1.8 1 1 0 1 1 1 0 FTO C-terminal domain DUF3446 PF11928.3 EFE41591.1 - 3.4 7.9 11.5 0.18 12.0 1.7 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF3446) DUF1115 PF06544.7 EFE41592.1 - 0.087 12.5 0.1 0.22 11.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) Ycf1 PF05758.7 EFE41593.1 - 0.064 10.9 0.3 0.055 11.2 0.2 1.0 1 0 0 1 1 1 0 Ycf1 DUF1675 PF07897.6 EFE41593.1 - 0.091 12.6 2.8 0.11 12.3 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) SOBP PF15279.1 EFE41593.1 - 0.11 12.9 19.9 0.13 12.5 13.8 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Neur_chan_memb PF02932.11 EFE41593.1 - 0.51 10.1 5.1 0.52 10.1 3.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4175 PF13779.1 EFE41593.1 - 0.54 7.8 22.0 0.69 7.5 15.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) BAF1_ABF1 PF04684.8 EFE41593.1 - 0.56 8.9 17.9 0.63 8.8 12.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RR_TM4-6 PF06459.7 EFE41593.1 - 1.3 8.8 10.8 1.8 8.4 7.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDK5_activator PF03261.10 EFE41593.1 - 1.6 7.9 9.4 2 7.7 6.5 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein UPF0560 PF10577.4 EFE41593.1 - 2 6.5 11.3 2.4 6.2 7.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 OmpH PF03938.9 EFE41593.1 - 2.2 8.2 17.3 3.1 7.7 12.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.1 EFE41593.1 - 2.3 7.1 5.8 2.5 6.9 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spt20 PF12090.3 EFE41593.1 - 2.8 7.2 9.1 4.2 6.6 6.3 1.3 1 0 0 1 1 1 0 Spt20 family Ilar_coat PF01787.11 EFE41593.1 - 3.3 7.2 7.5 4.8 6.6 5.2 1.3 1 0 0 1 1 1 0 Ilarvirus coat protein MCPVI PF02993.9 EFE41593.1 - 3.7 7.6 11.3 4.6 7.3 7.8 1.2 1 0 0 1 1 1 0 Minor capsid protein VI Hid1 PF12722.2 EFE41593.1 - 4.5 4.8 6.8 4.4 4.8 4.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Asp-B-Hydro_N PF05279.6 EFE41593.1 - 9.2 6.0 9.1 12 5.6 6.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Borrelia_P83 PF05262.6 EFE41593.1 - 9.5 4.3 10.7 12 4.0 7.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PAH PF02671.16 EFE41594.1 - 1.9e-46 155.4 0.5 8.5e-18 63.7 0.2 3.6 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 EFE41594.1 - 4e-41 138.8 0.1 9.1e-41 137.7 0.0 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor Glyco_hydro_17 PF00332.13 EFE41595.1 - 0.0087 15.1 0.0 0.14 11.1 0.1 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 17 DUF3203 PF11462.3 EFE41596.1 - 0.066 13.1 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3203) MFS_1 PF07690.11 EFE41597.1 - 6.4e-33 113.9 54.9 3.7e-31 108.1 38.1 3.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE41597.1 - 1.2e-11 43.6 25.0 2e-11 42.8 17.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE41597.1 - 2.5e-11 42.8 7.8 2.5e-11 42.8 5.4 2.9 3 1 0 3 3 3 1 Sugar (and other) transporter ATG22 PF11700.3 EFE41597.1 - 0.12 10.8 30.3 0.007 14.8 6.4 3.2 4 0 0 4 4 4 0 Vacuole effluxer Atg22 like Sel1 PF08238.7 EFE41598.1 - 8.3e-34 115.2 33.6 2.9e-05 24.5 1.9 7.7 7 0 0 7 7 7 7 Sel1 repeat TPR_11 PF13414.1 EFE41598.1 - 0.11 12.2 4.7 0.8 9.4 0.6 3.4 2 1 1 3 3 3 0 TPR repeat Chitin_synth_2 PF03142.10 EFE41599.1 - 1.6e-293 973.9 0.6 1.8e-293 973.7 0.0 1.3 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 EFE41599.1 - 1.3e-17 64.2 1.4 1.3e-17 64.2 1.0 2.0 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFE41599.1 - 9.7e-14 51.7 0.0 4e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 EFE41599.1 - 3.2e-06 26.8 0.0 7.8e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 EFE41599.1 - 1.7e-05 24.1 0.0 0.00021 20.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Selenoprotein_S PF06936.6 EFE41599.1 - 0.0092 15.5 0.2 0.043 13.3 0.1 2.1 2 0 0 2 2 2 1 Selenoprotein S (SelS) Glycos_transf_2 PF00535.21 EFE41599.1 - 0.011 15.4 0.0 0.046 13.3 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 2 OrfB_IS605 PF01385.14 EFE41599.1 - 0.69 9.2 2.2 0.88 8.9 0.5 1.8 2 0 0 2 2 2 0 Probable transposase TAF8_C PF10406.4 EFE41600.1 - 0.1 12.6 0.5 0.27 11.3 0.3 1.7 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term S_layer_C PF05124.7 EFE41600.1 - 0.15 11.6 0.2 0.2 11.2 0.1 1.1 1 0 0 1 1 1 0 S-layer like family, C-terminal region WD40 PF00400.27 EFE41601.1 - 2.9e-09 36.4 0.1 5.3e-07 29.2 0.0 3.7 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF123 PF01986.11 EFE41601.1 - 0.0071 16.4 0.1 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF123 DUF1582 PF07621.6 EFE41601.1 - 0.16 12.0 0.1 33 4.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1582) TRAPPC10 PF12584.3 EFE41602.1 - 1.1e-36 125.5 0.0 2.4e-36 124.4 0.0 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.3 EFE41602.1 - 0.018 14.5 0.1 0.035 13.5 0.1 1.4 1 0 0 1 1 1 0 Foie gras liver health family 1 G8 PF10162.4 EFE41602.1 - 0.04 13.7 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 G8 domain Ank PF00023.25 EFE41603.1 - 5.9e-13 47.9 5.4 3.8e-06 26.4 1.4 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 EFE41603.1 - 1.6e-11 44.3 0.1 3.4e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) TIG PF01833.19 EFE41603.1 - 1.9e-11 43.7 0.2 5.9e-11 42.2 0.2 1.9 1 0 0 1 1 1 1 IPT/TIG domain Ank_3 PF13606.1 EFE41603.1 - 6.6e-09 35.1 1.4 0.0024 17.9 0.4 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 EFE41603.1 - 4.7e-08 33.0 2.0 1.2e-05 25.3 0.7 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE41603.1 - 1.1e-07 32.2 1.0 2.9e-07 30.7 0.3 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Bap31 PF05529.7 EFE41603.1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Trypsin PF00089.21 EFE41604.1 - 4.9e-09 36.0 0.1 3e-08 33.5 0.1 2.0 1 1 1 2 2 2 1 Trypsin SUI1 PF01253.17 EFE41605.1 - 2.4e-14 52.8 0.0 6.7e-14 51.4 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 CHD5 PF04420.9 EFE41606.1 - 3.2e-35 121.1 7.8 2e-24 86.0 1.2 2.1 1 1 1 2 2 2 2 CHD5-like protein Mito_carr PF00153.22 EFE41607.1 - 4.6e-66 218.5 0.0 4.8e-22 77.4 0.0 3.4 2 2 1 3 3 3 3 Mitochondrial carrier protein UCR_14kD PF02271.11 EFE41608.1 - 2.2e-38 130.2 0.6 8.1e-38 128.4 0.4 1.8 1 1 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit PAS_3 PF08447.6 EFE41608.1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 PAS fold HhH-GPD PF00730.20 EFE41609.1 - 3.2e-14 53.1 0.0 5.6e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF4473 PF14747.1 EFE41609.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) Recep_L_domain PF01030.19 EFE41610.1 - 1.6e-12 47.4 3.0 0.031 14.2 0.0 5.3 1 1 5 6 6 6 6 Receptor L domain Ecm33 PF12454.3 EFE41610.1 - 3.4e-07 30.0 2.4 0.0037 17.1 0.0 2.9 2 0 0 2 2 2 2 GPI-anchored cell wall organization protein LRR_5 PF13306.1 EFE41610.1 - 0.0028 17.3 1.8 2.8 7.6 0.1 2.8 1 1 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_8 PF13855.1 EFE41610.1 - 0.054 13.2 0.7 0.054 13.2 0.5 3.4 3 1 0 3 3 3 0 Leucine rich repeat CAF1A PF12253.3 EFE41611.1 - 3.3 7.8 9.4 3.3 7.8 6.5 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Anp1 PF03452.9 EFE41612.1 - 6.6e-98 327.1 2.6 3.3e-62 210.0 0.1 2.1 2 0 0 2 2 2 2 Anp1 ABC1 PF03109.11 EFE41613.1 - 4.6e-32 110.4 0.0 9.3e-32 109.5 0.0 1.5 1 0 0 1 1 1 1 ABC1 family FA_desaturase PF00487.19 EFE41614.1 - 5.7e-28 98.0 11.1 1.3e-27 96.8 7.7 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.5 EFE41614.1 - 2.2e-18 65.2 0.4 3.8e-18 64.4 0.2 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) zf-C2H2_4 PF13894.1 EFE41615.1 - 8e-05 22.7 21.6 0.012 15.8 2.8 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFE41615.1 - 0.0045 17.2 0.9 0.0045 17.2 0.6 3.7 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EFE41615.1 - 0.0069 16.4 4.1 0.022 14.8 2.9 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding NosL PF05573.7 EFE41615.1 - 0.022 14.4 1.6 0.035 13.7 0.0 2.0 2 0 0 2 2 2 0 NosL zf-C2H2 PF00096.21 EFE41615.1 - 0.027 14.8 3.5 0.027 14.8 2.4 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type DUF2614 PF11023.3 EFE41615.1 - 0.25 11.1 0.7 0.43 10.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2614) Cytochrome_C7 PF14522.1 EFE41615.1 - 7.5 6.2 15.5 1.8 8.2 8.0 2.1 2 1 0 2 2 2 0 Cytochrome c7 Vps8 PF12816.2 EFE41616.1 - 1.1e-70 236.9 0.1 3.8e-70 235.1 0.0 2.0 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.15 EFE41616.1 - 1.6e-08 34.2 6.0 0.00061 19.4 0.2 4.6 4 1 0 4 4 4 2 Region in Clathrin and VPS Pox_D3 PF04580.8 EFE41616.1 - 0.028 13.6 0.3 0.073 12.2 0.1 1.8 2 0 0 2 2 2 0 Chordopoxvirinae D3 protein zf-RING_2 PF13639.1 EFE41616.1 - 0.048 13.5 0.7 0.17 11.7 0.5 2.0 1 0 0 1 1 1 0 Ring finger domain zf-Apc11 PF12861.2 EFE41616.1 - 0.12 12.1 0.2 0.61 9.9 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H_2 PF13832.1 EFE41617.1 - 2.9e-24 85.1 0.8 2.9e-24 85.1 0.6 3.5 2 1 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFE41617.1 - 3.8e-23 81.4 2.9 3.8e-23 81.4 2.0 4.0 3 0 0 3 3 3 1 PHD-like zinc-binding domain BAH PF01426.13 EFE41617.1 - 1.1e-11 44.4 0.2 3.6e-11 42.8 0.1 1.9 2 0 0 2 2 2 1 BAH domain PHD_2 PF13831.1 EFE41617.1 - 7.9e-09 34.6 2.8 7.9e-09 34.6 2.0 4.6 5 0 0 5 5 5 1 PHD-finger PHD PF00628.24 EFE41617.1 - 4.7e-07 29.4 7.3 4.7e-07 29.4 5.0 5.1 6 0 0 6 6 6 2 PHD-finger zf-RING-like PF08746.6 EFE41617.1 - 0.024 14.6 24.9 0.3 11.1 5.3 3.2 2 0 0 2 2 2 0 RING-like domain Prok-RING_1 PF14446.1 EFE41617.1 - 8.9 6.1 25.5 0.13 12.0 2.5 3.6 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 JAB PF01398.16 EFE41619.1 - 2.1e-14 53.2 0.0 3.6e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 EFE41619.1 - 6e-07 28.9 0.0 1.3e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain USP8_dimer PF08969.6 EFE41619.1 - 2.3e-05 24.3 0.0 4.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain Fmp27_WPPW PF10359.4 EFE41619.1 - 2.1 6.6 6.4 0.6 8.4 1.8 1.7 1 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain HR1 PF02185.11 EFE41619.1 - 2.2 8.0 5.1 0.81 9.4 1.3 1.9 2 0 0 2 2 2 0 Hr1 repeat TBCC PF07986.7 EFE41620.1 - 5.3e-25 87.1 2.1 1e-24 86.2 1.5 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C DivIVA PF05103.8 EFE41621.1 - 0.00061 19.8 21.8 0.048 13.7 4.7 3.6 2 1 1 3 3 3 2 DivIVA protein HAP1_N PF04849.8 EFE41621.1 - 0.46 9.3 28.3 0.61 8.9 0.1 2.8 2 1 0 2 2 2 0 HAP1 N-terminal conserved region HR1 PF02185.11 EFE41621.1 - 1.8 8.3 19.1 0.84 9.4 0.3 3.7 2 1 0 2 2 2 0 Hr1 repeat CCDC66 PF15236.1 EFE41622.1 - 0.26 10.8 6.2 0.33 10.5 4.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 V-ATPase_G PF03179.10 EFE41623.1 - 2.4e-22 79.2 8.9 3.3e-22 78.7 6.2 1.2 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit UPF0258 PF06789.7 EFE41623.1 - 0.036 14.1 0.3 0.049 13.6 0.2 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0258) HypD PF01924.11 EFE41623.1 - 0.1 11.3 0.8 0.12 11.0 0.6 1.1 1 0 0 1 1 1 0 Hydrogenase formation hypA family Colicin-DNase PF12639.2 EFE41623.1 - 0.26 11.5 2.9 0.33 11.2 2.0 1.3 1 0 0 1 1 1 0 DNase/tRNase domain of colicin-like bacteriocin DUF4647 PF15504.1 EFE41623.1 - 0.47 9.2 8.5 0.49 9.1 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) ATP-synt_B PF00430.13 EFE41623.1 - 0.91 9.3 9.7 1.6 8.5 6.7 1.4 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF4407 PF14362.1 EFE41623.1 - 2.1 7.2 8.7 2.4 7.0 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.7 EFE41623.1 - 2.5 7.9 9.7 3 7.6 6.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2229 PF09989.4 EFE41623.1 - 5.7 6.3 5.9 10 5.4 4.1 1.6 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Helicase_C PF00271.26 EFE41625.1 - 8.8e-20 70.3 0.0 2.2e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE41625.1 - 5.2e-19 68.3 0.0 1.6e-18 66.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EFE41625.1 - 7.2e-18 65.0 0.0 1.8e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 EFE41625.1 - 0.11 11.4 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) F_actin_cap_B PF01115.12 EFE41626.1 - 3.6e-101 337.3 0.0 3.9e-99 330.7 0.0 2.0 2 0 0 2 2 2 2 F-actin capping protein, beta subunit Med11 PF10280.4 EFE41627.1 - 3.4e-33 114.1 0.1 4.5e-33 113.7 0.1 1.2 1 0 0 1 1 1 1 Mediator complex protein WD40 PF00400.27 EFE41628.1 - 9.5e-59 193.3 23.5 6.4e-11 41.6 1.4 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 EFE41628.1 - 6e-21 75.0 0.0 9e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit Nup160 PF11715.3 EFE41628.1 - 2.7e-07 29.1 1.4 0.00016 19.9 0.1 3.3 3 1 0 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFE41628.1 - 0.00023 20.0 0.1 2.9 6.5 0.0 3.8 2 1 2 4 4 4 2 Nup133 N terminal like eIF2A PF08662.6 EFE41628.1 - 0.0054 16.4 0.1 0.037 13.7 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Abhydrolase_6 PF12697.2 EFE41629.1 - 6.8e-23 81.7 0.2 1.5e-22 80.5 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE41629.1 - 9.7e-09 35.1 0.1 1.9e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE41629.1 - 8e-08 32.1 0.0 1.8e-07 30.9 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.20 EFE41629.1 - 0.018 14.6 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Thioesterase PF00975.15 EFE41629.1 - 0.027 14.7 0.2 0.21 11.8 0.1 2.1 1 1 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.8 EFE41629.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2417 PF10329.4 EFE41630.1 - 2.7e-81 272.3 1.1 3.7e-81 271.9 0.7 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_6 PF12697.2 EFE41630.1 - 2.4e-08 34.1 0.5 4.2e-08 33.3 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Scs3p PF10261.4 EFE41630.1 - 0.0083 15.1 0.2 0.56 9.2 0.5 2.2 2 0 0 2 2 2 1 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2975 PF11188.3 EFE41630.1 - 0.052 13.2 13.1 0.29 10.8 2.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) Pox_A9 PF04835.7 EFE41630.1 - 0.18 11.7 1.6 12 5.9 0.1 2.6 2 0 0 2 2 2 0 A9 protein conserved region PMSR PF01625.16 EFE41631.1 - 3.7e-58 195.8 0.3 4.2e-58 195.6 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pro_dh PF01619.13 EFE41632.1 - 8.5e-31 107.0 0.2 8.9e-20 70.8 0.0 2.2 2 0 0 2 2 2 2 Proline dehydrogenase GFA PF04828.9 EFE41633.1 - 0.0019 18.0 0.8 0.004 17.0 0.5 1.6 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Ribosomal_60s PF00428.14 EFE41633.1 - 0.12 12.7 4.7 0.19 12.1 3.3 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Glyco_hydro_16 PF00722.16 EFE41634.1 - 3.5e-42 143.7 3.1 5.5e-42 143.1 2.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Alk_phosphatase PF00245.15 EFE41635.1 - 8e-112 373.9 0.0 9.9e-112 373.6 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 EFE41635.1 - 0.00037 19.9 0.5 0.0012 18.3 0.0 1.9 2 0 0 2 2 2 1 Metalloenzyme superfamily RskA PF10099.4 EFE41635.1 - 0.023 14.4 0.1 0.059 13.1 0.0 1.7 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF498 PF04430.9 EFE41636.1 - 0.095 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) ABC_tran PF00005.22 EFE41637.1 - 2.4e-33 115.3 0.0 4.8e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EFE41637.1 - 7.9e-24 84.5 8.0 7.9e-24 84.5 5.5 2.3 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.14 EFE41637.1 - 2.4e-07 30.2 0.1 6.6e-05 22.2 0.0 2.9 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE41637.1 - 0.00045 20.2 0.0 0.096 12.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 EFE41637.1 - 0.0061 16.4 0.3 0.055 13.3 0.2 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 EFE41637.1 - 0.0091 15.5 0.2 0.021 14.3 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 EFE41637.1 - 0.017 14.3 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFE41637.1 - 0.036 14.2 0.1 0.18 11.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFE41637.1 - 0.064 13.2 0.5 0.16 11.9 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain DUF1673 PF07895.6 EFE41637.1 - 0.39 10.2 5.0 1.3 8.4 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1673) Herpes_LMP1 PF05297.6 EFE41637.1 - 1 8.1 5.0 0.19 10.6 0.6 1.8 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) MIP-T3 PF10243.4 EFE41638.1 - 8.1 4.7 43.7 9.8 4.5 30.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 eIF3g PF12353.3 EFE41642.1 - 3e-47 159.7 1.4 5.2e-47 158.9 1.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 EFE41642.1 - 7.6e-17 60.7 0.1 1.3e-16 59.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41642.1 - 2e-13 50.1 0.1 3.4e-13 49.3 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41642.1 - 4.6e-08 32.7 0.0 1e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NMO PF03060.10 EFE41643.1 - 3.4e-71 240.1 1.4 4.2e-71 239.7 1.0 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFE41643.1 - 4.1e-08 32.4 0.1 3.3e-07 29.5 0.1 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EFE41643.1 - 2.3e-07 30.0 1.8 4.7e-07 28.9 1.3 1.5 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DHO_dh PF01180.16 EFE41643.1 - 0.00082 18.4 0.3 0.0013 17.7 0.2 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.12 EFE41643.1 - 0.0055 15.6 0.6 0.0084 15.0 0.1 1.5 2 0 0 2 2 2 1 Conserved region in glutamate synthase TipAS PF07739.8 EFE41643.1 - 0.11 12.7 0.4 0.31 11.3 0.0 1.8 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Pterin_bind PF00809.17 EFE41644.1 - 8e-67 224.6 0.0 1.5e-66 223.7 0.0 1.5 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.15 EFE41644.1 - 5.2e-39 132.8 0.0 8.6e-39 132.1 0.0 1.4 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) TIM21 PF08294.6 EFE41646.1 - 1.1e-06 28.3 0.0 0.016 14.8 0.0 2.1 2 0 0 2 2 2 2 TIM21 MR_MLE_C PF13378.1 EFE41647.1 - 9.9e-19 67.3 0.0 3e-18 65.7 0.0 1.9 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE PF01188.16 EFE41647.1 - 1.8e-14 54.0 0.2 1e-12 48.3 0.0 2.6 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 EFE41647.1 - 7.2e-07 29.2 0.1 1.4e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.6 EFE41647.1 - 0.0071 15.3 0.0 0.019 13.9 0.0 1.7 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus Aminotran_5 PF00266.14 EFE41648.1 - 9.4e-28 96.9 0.0 1.5e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V PWI PF01480.12 EFE41649.1 - 4.7e-12 45.8 0.4 1.9e-11 43.9 0.3 2.1 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.17 EFE41649.1 - 0.023 14.3 0.0 0.057 13.0 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PGI PF00342.14 EFE41652.1 - 5e-220 731.0 1.9 5.7e-220 730.8 1.3 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Urease_beta PF00699.15 EFE41652.1 - 0.024 14.4 0.1 0.051 13.4 0.1 1.5 1 0 0 1 1 1 0 Urease beta subunit Ribosomal_S21 PF01165.15 EFE41654.1 - 4e-08 32.5 1.0 9.7e-08 31.3 0.7 1.7 1 0 0 1 1 1 1 Ribosomal protein S21 Spidroin_MaSp PF11260.3 EFE41654.1 - 0.093 12.8 0.7 0.85 9.7 0.3 2.3 2 0 0 2 2 2 0 Major ampullate spidroin 1 and 2 Involucrin_N PF10583.4 EFE41654.1 - 5.6 7.3 8.7 12 6.3 6.1 1.5 1 1 0 1 1 1 0 Involucrin of squamous epithelia N-terminus Rhodanese PF00581.15 EFE41655.1 - 1.2e-10 41.6 0.0 1.5e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_28 PF02636.12 EFE41656.1 - 1.4e-75 253.9 0.0 8e-62 208.8 0.0 2.1 2 0 0 2 2 2 2 Putative S-adenosyl-L-methionine-dependent methyltransferase RRM_1 PF00076.17 EFE41657.1 - 3.1e-05 23.5 0.0 5.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41657.1 - 0.0041 17.0 0.0 0.021 14.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41657.1 - 0.048 13.5 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gar1 PF04410.9 EFE41659.1 - 5e-45 152.7 0.2 5e-45 152.7 0.1 1.8 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region HET PF06985.6 EFE41660.1 - 1e-10 41.8 0.0 1.9e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Glyco_transf_22 PF03901.12 EFE41661.1 - 8.9e-44 150.1 9.4 1e-43 149.9 6.5 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family zf-C2H2_4 PF13894.1 EFE41662.1 - 3.6e-07 30.0 17.2 0.0027 17.9 0.9 4.2 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE41662.1 - 5.6e-06 26.3 27.1 0.00034 20.7 0.9 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type Cwf_Cwc_15 PF04889.7 EFE41663.1 - 0.19 11.3 3.7 0.24 11.0 2.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein YqzE PF14038.1 EFE41663.1 - 0.72 9.6 4.3 1.3 8.8 3.0 1.5 1 0 0 1 1 1 0 YqzE-like protein Histone PF00125.19 EFE41666.1 - 2.2e-15 56.5 0.1 2.9e-15 56.1 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 EFE41666.1 - 0.00017 21.4 0.1 0.00025 20.9 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 EFE41666.1 - 0.00019 21.5 0.1 0.00027 21.0 0.1 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EFE41666.1 - 0.00059 19.8 0.1 0.0012 18.8 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EFE41666.1 - 0.034 13.8 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 EFE41666.1 - 0.074 12.2 0.0 0.078 12.2 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TFIID-31kDa PF02291.10 EFE41666.1 - 0.15 11.8 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.19 EFE41667.1 - 3.3e-30 103.9 0.5 5.4e-30 103.3 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EFE41667.1 - 2.7e-06 27.4 0.0 4.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 EFE41667.1 - 0.0059 16.3 0.1 0.0097 15.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.18 EFE41667.1 - 0.0081 16.2 0.2 0.026 14.5 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Exo5 PF09810.4 EFE41668.1 - 2.7e-94 316.0 0.0 4.7e-94 315.2 0.0 1.4 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease Mpv17_PMP22 PF04117.7 EFE41668.1 - 2.6e-15 55.7 1.0 6.5e-15 54.5 0.7 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family PDDEXK_1 PF12705.2 EFE41668.1 - 0.012 14.9 0.0 0.93 8.8 0.0 3.0 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily ChAPs PF09295.5 EFE41670.1 - 2.6e-126 421.5 0.0 5e-95 318.5 0.0 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 EFE41670.1 - 0.00014 21.4 0.1 0.036 13.7 0.0 2.5 2 0 0 2 2 2 1 TPR repeat TPR_14 PF13428.1 EFE41670.1 - 0.00022 21.5 1.6 4.1 8.3 0.0 4.6 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFE41670.1 - 0.00027 20.6 0.1 0.71 9.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFE41670.1 - 0.00032 20.1 0.2 5.5 6.7 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 EFE41670.1 - 0.00056 20.0 0.0 0.094 12.8 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 EFE41670.1 - 0.0017 18.1 0.4 0.69 9.8 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE41670.1 - 0.02 14.6 0.0 20 5.2 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFE41670.1 - 0.031 14.1 0.6 2.7 8.0 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE41670.1 - 0.053 13.8 0.0 4.8 7.5 0.0 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat YejG PF13989.1 EFE41670.1 - 0.13 12.3 0.2 0.57 10.2 0.0 2.1 2 0 0 2 2 2 0 YejG-like protein Sigma70_ner PF04546.8 EFE41670.1 - 0.15 11.6 4.6 0.62 9.6 2.9 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region Daxx PF03344.10 EFE41670.1 - 0.79 8.1 12.3 1.1 7.6 8.5 1.1 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EFE41670.1 - 3 5.6 10.4 4.1 5.2 7.2 1.1 1 0 0 1 1 1 0 Nop14-like family Kinesin PF00225.18 EFE41672.1 - 4.4e-55 186.7 0.0 1.1e-54 185.4 0.0 1.7 1 1 0 1 1 1 1 Kinesin motor domain bZIP_2 PF07716.10 EFE41672.1 - 0.0026 17.5 1.2 0.0085 15.8 0.9 1.9 1 0 0 1 1 1 1 Basic region leucine zipper DUF87 PF01935.12 EFE41672.1 - 0.7 9.6 3.8 3.2 7.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 zf-PARP PF00645.13 EFE41673.1 - 1e-21 76.9 0.2 4.3e-21 74.9 0.2 2.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DUF1168 PF06658.7 EFE41674.1 - 3.4e-43 146.5 12.3 5.1e-43 145.9 8.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) eIF-3_zeta PF05091.7 EFE41674.1 - 0.11 11.1 3.3 0.12 10.9 2.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2201_N PF13203.1 EFE41674.1 - 1.2 8.2 7.0 1.6 7.8 4.9 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain RNA_polI_A34 PF08208.6 EFE41674.1 - 1.5 8.4 17.8 1.9 8.1 12.3 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Peptidase_S49_N PF08496.5 EFE41674.1 - 2.6 7.8 10.0 4.8 6.9 6.9 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Vfa1 PF08432.5 EFE41674.1 - 3 7.8 13.1 5.1 7.0 9.1 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.9 EFE41674.1 - 6.2 4.7 6.4 7.4 4.4 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.11 EFE41674.1 - 8.3 5.8 23.9 14 5.1 16.4 1.5 1 1 0 1 1 1 0 HSV U79 / HCMV P34 Cpn60_TCP1 PF00118.19 EFE41675.1 - 1e-154 515.7 0.8 1.2e-154 515.5 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Lactamase_B_2 PF12706.2 EFE41676.1 - 6.9e-14 51.8 0.0 1.9e-13 50.4 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EFE41676.1 - 3.1e-08 33.4 0.0 7.1e-08 32.3 0.0 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain BCS1_N PF08740.6 EFE41677.1 - 5.7e-54 182.5 0.4 7.6e-54 182.1 0.3 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 EFE41677.1 - 1.3e-18 67.4 0.0 2.5e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EFE41677.1 - 7.3e-06 26.3 0.0 0.0035 17.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFE41677.1 - 4e-05 24.4 0.1 0.00012 22.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE41677.1 - 0.00019 21.4 0.2 0.0011 18.9 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 EFE41677.1 - 0.00063 19.6 0.0 0.0021 17.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 EFE41677.1 - 0.00077 18.4 0.0 0.0015 17.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 EFE41677.1 - 0.0015 18.6 0.0 0.018 15.2 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 EFE41677.1 - 0.0098 15.3 0.0 0.032 13.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EFE41677.1 - 0.013 15.2 0.0 0.037 13.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 EFE41677.1 - 0.018 14.5 0.0 0.059 12.9 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.17 EFE41677.1 - 0.029 14.5 0.0 0.093 12.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ABC_tran PF00005.22 EFE41677.1 - 0.031 14.5 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_19 PF13245.1 EFE41677.1 - 0.042 13.6 2.7 0.078 12.7 0.0 2.8 4 0 0 4 4 4 0 Part of AAA domain AAA_11 PF13086.1 EFE41677.1 - 0.055 13.0 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 EFE41677.1 - 0.067 12.3 0.0 0.29 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF2735 PF10931.3 EFE41677.1 - 0.078 13.2 0.0 0.27 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2735) Zeta_toxin PF06414.7 EFE41677.1 - 0.11 11.5 0.0 0.35 9.9 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin KaiC PF06745.8 EFE41677.1 - 0.12 11.4 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 KaiC Miro PF08477.8 EFE41677.1 - 0.15 12.5 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein RabGAP-TBC PF00566.13 EFE41679.1 - 3.5e-36 124.7 0.2 3.7e-35 121.3 0.0 2.6 2 1 0 2 2 2 1 Rab-GTPase-TBC domain Glyco_transf_41 PF13844.1 EFE41680.1 - 7.7e-98 327.4 0.3 1.7e-50 171.3 0.0 3.3 2 1 1 3 3 3 3 Glycosyl transferase family 41 TPR_11 PF13414.1 EFE41680.1 - 2e-20 72.2 14.7 1.8e-08 33.9 0.1 4.6 4 0 0 4 4 4 4 TPR repeat TPR_2 PF07719.12 EFE41680.1 - 4.2e-15 54.3 10.7 0.00078 19.1 0.1 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 EFE41680.1 - 5.4e-14 51.1 9.4 0.0008 18.9 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFE41680.1 - 9.6e-11 41.4 7.7 0.00026 20.8 0.1 4.4 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE41680.1 - 3.2e-10 39.7 6.3 0.0036 17.7 0.1 5.6 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 EFE41680.1 - 1.9e-09 36.9 4.3 0.51 10.6 0.0 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFE41680.1 - 9e-09 35.7 10.2 0.0012 19.5 0.2 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFE41680.1 - 2.9e-06 27.5 2.7 0.0074 16.6 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE41680.1 - 5.2e-05 23.2 0.2 0.017 15.2 0.0 2.9 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EFE41680.1 - 0.00068 19.2 9.9 0.05 13.4 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE41680.1 - 0.001 18.7 7.1 1.3 8.9 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.12 EFE41680.1 - 0.0046 17.2 0.6 3.5 7.9 0.3 2.8 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_6 PF13174.1 EFE41680.1 - 0.019 15.3 4.9 6.5 7.4 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_15 PF13429.1 EFE41680.1 - 0.039 13.0 1.4 3 6.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFE41680.1 - 0.12 12.3 15.4 3.9 7.5 0.4 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat RAM PF15320.1 EFE41681.1 - 0.0045 17.2 2.6 0.0045 17.2 1.8 3.6 2 1 1 3 3 3 1 mRNA cap methylation, RNMT-activating mini protein DUF1168 PF06658.7 EFE41681.1 - 0.45 10.0 31.0 0.26 10.7 8.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1168) Ribosomal_L11_N PF03946.9 EFE41682.1 - 1e-12 47.2 0.5 1.9e-11 43.2 0.3 2.2 1 1 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 EFE41682.1 - 4.5e-09 36.3 0.0 7.7e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Sec23_trunk PF04811.10 EFE41683.1 - 7.3e-78 261.2 0.0 1e-77 260.8 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EFE41683.1 - 2.3e-33 113.6 0.3 4.3e-33 112.8 0.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 EFE41683.1 - 9e-29 99.8 0.0 1.8e-28 98.8 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EFE41683.1 - 5.9e-16 57.7 4.9 1.1e-15 56.9 3.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EFE41683.1 - 0.0018 17.9 0.0 0.0051 16.4 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat DNA_primase_lrg PF04104.9 EFE41684.1 - 6.3e-82 274.7 0.0 9.2e-82 274.1 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Phage_head_chap PF11113.3 EFE41684.1 - 0.1 12.5 0.1 0.45 10.4 0.1 2.1 1 0 0 1 1 1 0 Head assembly gene product ADK PF00406.17 EFE41685.1 - 1.8e-35 122.0 0.0 2.3e-19 69.7 0.0 2.1 1 1 1 2 2 2 2 Adenylate kinase ADK_lid PF05191.9 EFE41685.1 - 9.3e-16 57.2 0.0 1.6e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.1 EFE41685.1 - 0.00013 22.2 0.0 0.001 19.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE41685.1 - 0.00063 20.5 0.0 0.0011 19.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE41685.1 - 0.0034 17.2 0.0 0.015 15.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFE41685.1 - 0.062 12.3 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin ArgK PF03308.11 EFE41685.1 - 0.086 11.6 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 ArgK protein AAA_28 PF13521.1 EFE41685.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EFE41685.1 - 0.15 11.7 0.1 0.28 10.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SNase PF00565.12 EFE41686.1 - 6.9e-12 45.5 0.0 1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Mito_carr PF00153.22 EFE41687.1 - 2.6e-55 184.1 3.7 2.5e-21 75.1 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C2 PF00648.16 EFE41688.1 - 1.5e-24 86.5 0.0 2.6e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 EFE41688.1 - 2.4e-17 62.9 0.0 1.4e-13 50.7 0.0 3.1 2 1 0 2 2 2 2 Calpain large subunit, domain III MIT PF04212.13 EFE41688.1 - 8e-05 22.4 2.1 0.00015 21.5 1.5 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Glyco_transf_29 PF00777.13 EFE41688.1 - 0.22 10.6 0.0 0.41 9.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 29 (sialyltransferase) DUF605 PF04652.11 EFE41689.1 - 2.4e-98 330.0 20.1 2.8e-98 329.8 13.9 1.0 1 0 0 1 1 1 1 Vta1 like DUF812 PF05667.6 EFE41689.1 - 0.028 12.9 4.1 0.044 12.2 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Epimerase PF01370.16 EFE41692.1 - 1.3e-19 70.6 0.0 2e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFE41692.1 - 1.1e-07 30.8 0.0 3.3e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EFE41692.1 - 3.5e-07 29.4 0.0 5.1e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.20 EFE41692.1 - 1.7e-05 24.8 0.0 3.7e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EFE41692.1 - 0.00017 21.6 0.1 0.0016 18.5 0.0 2.1 1 1 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 EFE41692.1 - 0.022 13.7 0.0 0.033 13.1 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase KR PF08659.5 EFE41692.1 - 0.054 13.1 0.1 0.14 11.7 0.1 1.8 1 1 0 1 1 1 0 KR domain Ldh_1_N PF00056.18 EFE41692.1 - 0.12 12.1 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain NAD_binding_4 PF07993.7 EFE41692.1 - 0.14 11.0 0.0 5.2 5.9 0.0 2.3 2 0 0 2 2 2 0 Male sterility protein Topoisom_I_N PF02919.10 EFE41693.1 - 1.5e-97 325.1 1.1 1.5e-97 325.1 0.8 3.7 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 EFE41693.1 - 4e-86 287.9 2.4 4e-86 287.9 1.7 2.9 3 1 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 EFE41693.1 - 1e-31 108.3 0.6 1e-31 108.3 0.4 2.0 2 0 0 2 2 2 1 C-terminal topoisomerase domain ATP-synt PF00231.14 EFE41694.1 - 6.3e-61 206.2 2.6 7.7e-61 205.9 1.8 1.1 1 0 0 1 1 1 1 ATP synthase DUF1957 PF09210.6 EFE41694.1 - 0.062 13.3 0.2 0.16 12.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1957) DUF4312 PF14189.1 EFE41695.1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4312) Thioredoxin PF00085.15 EFE41696.1 - 5e-24 83.9 0.0 6.7e-19 67.5 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 EFE41696.1 - 3.9e-06 27.0 3.3 0.003 17.7 0.1 3.2 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFE41696.1 - 0.00039 20.4 0.2 0.093 12.8 0.0 3.7 3 1 1 4 4 4 2 Thioredoxin-like Spore_coat_CotO PF14153.1 EFE41696.1 - 4.9 6.5 14.3 0.049 13.0 1.6 2.1 2 0 0 2 2 2 0 Spore coat protein CotO Hid1 PF12722.2 EFE41696.1 - 9.9 3.6 7.9 15 3.0 5.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GNAT_acetyltr_2 PF13718.1 EFE41697.1 - 5.8e-80 267.2 0.0 1e-79 266.4 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 EFE41697.1 - 1.2e-65 220.4 0.0 2.9e-65 219.2 0.0 1.7 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.6 EFE41697.1 - 1.1e-40 137.2 0.1 3.1e-40 135.7 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 EFE41697.1 - 9.8e-36 121.9 0.2 2.6e-35 120.5 0.2 1.8 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_1 PF00583.19 EFE41697.1 - 0.017 15.1 0.0 0.057 13.4 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE41697.1 - 0.021 15.0 0.0 0.065 13.4 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF202 PF02656.10 EFE41699.1 - 0.12 12.6 2.5 1.8 8.8 0.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Glyco_transf_90 PF05686.7 EFE41700.1 - 1.8e-15 56.5 0.0 1.1e-07 30.9 0.0 3.7 2 2 1 3 3 3 2 Glycosyl transferase family 90 Glyco_hydro_16 PF00722.16 EFE41701.1 - 6.3e-10 38.6 0.5 1.1e-09 37.8 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 DSPc PF00782.15 EFE41702.1 - 3.1e-16 59.1 0.0 3.1e-09 36.5 0.0 2.1 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Vfa1 PF08432.5 EFE41703.1 - 8e-37 127.0 34.0 1.9e-23 83.4 21.3 2.0 1 1 1 2 2 2 2 AAA-ATPase Vps4-associated protein 1 Rtf2 PF04641.7 EFE41703.1 - 0.00039 19.6 18.4 0.00056 19.2 12.8 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger RR_TM4-6 PF06459.7 EFE41703.1 - 0.0039 17.1 17.8 0.0053 16.6 12.3 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 CDC45 PF02724.9 EFE41703.1 - 0.011 13.8 17.2 0.012 13.7 11.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Caldesmon PF02029.10 EFE41703.1 - 0.015 13.7 25.7 0.016 13.6 17.8 1.1 1 0 0 1 1 1 0 Caldesmon DUF1510 PF07423.6 EFE41703.1 - 0.015 14.6 24.9 0.021 14.1 17.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Atrophin-1 PF03154.10 EFE41703.1 - 0.015 13.4 14.5 0.023 12.9 10.0 1.3 1 0 0 1 1 1 0 Atrophin-1 family MIP-T3 PF10243.4 EFE41703.1 - 0.022 13.2 29.8 0.025 13.0 20.6 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Sporozoite_P67 PF05642.6 EFE41703.1 - 0.043 11.6 8.1 0.048 11.5 5.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Daxx PF03344.10 EFE41703.1 - 0.065 11.7 18.2 0.073 11.5 12.6 1.0 1 0 0 1 1 1 0 Daxx Family Ycf1 PF05758.7 EFE41703.1 - 0.12 10.0 17.3 0.14 9.8 12.0 1.0 1 0 0 1 1 1 0 Ycf1 Raftlin PF15250.1 EFE41703.1 - 0.14 10.6 8.3 0.16 10.4 5.7 1.1 1 0 0 1 1 1 0 Raftlin SET PF00856.23 EFE41703.1 - 0.19 11.9 4.9 0.26 11.5 3.4 1.1 1 0 0 1 1 1 0 SET domain DUF262 PF03235.9 EFE41703.1 - 0.24 11.3 8.2 0.27 11.1 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF4407 PF14362.1 EFE41703.1 - 0.25 10.2 9.2 0.27 10.1 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAPS PF04499.10 EFE41703.1 - 0.41 9.2 12.6 0.45 9.0 8.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MSA_2 PF00985.12 EFE41703.1 - 0.49 10.5 6.4 0.62 10.1 4.4 1.2 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family FLO_LFY PF01698.11 EFE41703.1 - 0.58 8.9 13.1 0.72 8.6 9.1 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein GAGA_bind PF06217.7 EFE41703.1 - 0.58 10.0 13.3 0.65 9.9 9.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_11 PF13086.1 EFE41703.1 - 0.75 9.3 8.2 0.84 9.1 5.7 1.3 1 0 0 1 1 1 0 AAA domain DDHD PF02862.12 EFE41703.1 - 0.77 9.5 9.5 1 9.1 6.6 1.4 1 0 0 1 1 1 0 DDHD domain Borrelia_P83 PF05262.6 EFE41703.1 - 0.99 7.5 22.3 1.2 7.3 15.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3449 PF11931.3 EFE41703.1 - 1.1 8.7 16.4 1.6 8.1 11.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Ctr PF04145.10 EFE41703.1 - 1.3 9.0 3.2 1.9 8.4 2.2 1.4 1 0 0 1 1 1 0 Ctr copper transporter family DUF913 PF06025.7 EFE41703.1 - 1.3 7.6 4.3 1.5 7.4 2.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Herpes_Helicase PF02689.9 EFE41703.1 - 1.5 6.4 4.3 1.8 6.1 2.9 1.0 1 0 0 1 1 1 0 Helicase Paramyxo_ncap PF00973.14 EFE41703.1 - 1.6 7.3 9.8 1.7 7.2 6.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein NARP1 PF12569.3 EFE41703.1 - 1.6 7.3 22.2 2.4 6.7 15.4 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4220 PF13968.1 EFE41703.1 - 1.8 7.5 5.8 1.8 7.5 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) UPF0560 PF10577.4 EFE41703.1 - 2 6.5 14.3 2.3 6.3 9.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 APG6 PF04111.7 EFE41703.1 - 2.1 7.3 12.3 2.6 7.0 8.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Atg14 PF10186.4 EFE41703.1 - 2.5 6.9 10.7 3 6.6 7.4 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 BTV_NS2 PF04514.7 EFE41703.1 - 2.8 6.7 18.1 3.4 6.4 12.6 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 SpoIIIAH PF12685.2 EFE41703.1 - 2.9 7.3 17.6 5.9 6.3 12.2 1.5 1 1 0 1 1 1 0 SpoIIIAH-like protein ATP11 PF06644.6 EFE41703.1 - 3.2 7.1 15.9 4 6.8 11.0 1.2 1 0 0 1 1 1 0 ATP11 protein RNase_H2-Ydr279 PF09468.5 EFE41703.1 - 4 6.5 18.4 6.3 5.9 12.7 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) TP53IP5 PF15331.1 EFE41703.1 - 4.3 7.1 13.4 5.2 6.9 9.3 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 GCD14 PF08704.5 EFE41703.1 - 4.5 6.7 6.1 5.3 6.4 4.2 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Presenilin PF01080.12 EFE41703.1 - 6 5.5 6.6 7 5.3 4.5 1.1 1 0 0 1 1 1 0 Presenilin DUF2413 PF10310.4 EFE41703.1 - 8.1 5.1 22.2 11 4.7 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Mem_trans PF03547.13 EFE41703.1 - 8.5 4.5 9.6 9.4 4.4 6.6 1.1 1 0 0 1 1 1 0 Membrane transport protein CarboxypepD_reg PF13620.1 EFE41704.1 - 0.023 14.7 1.5 0.25 11.4 0.2 2.3 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain Asp PF00026.18 EFE41705.1 - 4.5e-70 236.4 1.7 5.4e-70 236.1 1.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFE41705.1 - 2.1e-06 27.7 0.0 9.3e-06 25.6 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFE41705.1 - 2.6e-05 24.6 0.2 0.0091 16.4 0.0 3.0 2 2 0 2 2 2 2 Aspartyl protease RVP PF00077.15 EFE41705.1 - 0.045 13.6 0.1 2.3 8.1 0.0 2.8 3 0 0 3 3 3 0 Retroviral aspartyl protease RNA_pol_Rpb1_5 PF04998.12 EFE41706.1 - 3.6e-87 292.1 0.0 1.7e-86 289.9 0.0 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 EFE41706.1 - 1.5e-83 280.9 0.0 2.6e-83 280.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 EFE41706.1 - 1.5e-66 223.4 0.0 2.9e-66 222.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 EFE41706.1 - 2e-34 118.6 0.0 4e-34 117.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 EFE41706.1 - 2.2e-25 88.4 0.6 6.8e-25 86.9 0.4 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 SAP PF02037.22 EFE41707.1 - 0.00016 21.0 0.1 0.0015 18.0 0.0 2.2 2 0 0 2 2 2 1 SAP domain FMN_dh PF01070.13 EFE41708.1 - 1.9e-102 342.7 0.0 4.3e-100 335.0 0.0 2.2 2 0 0 2 2 2 2 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EFE41708.1 - 4.9e-17 61.4 0.0 9.6e-17 60.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 EFE41708.1 - 0.0011 17.9 0.0 0.0017 17.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.9 EFE41708.1 - 0.024 13.7 0.0 0.093 11.7 0.0 1.8 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG IMPDH PF00478.20 EFE41708.1 - 0.082 11.7 0.8 0.24 10.2 0.0 2.0 3 0 0 3 3 3 0 IMP dehydrogenase / GMP reductase domain TatD_DNase PF01026.16 EFE41709.1 - 1.2e-40 139.3 0.0 1.4e-40 139.1 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Y_phosphatase2 PF03162.8 EFE41711.1 - 1.7e-42 144.6 0.0 2.4e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 EFE41711.1 - 4.9e-08 33.3 0.1 2.1e-07 31.3 0.0 1.9 1 1 1 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 EFE41711.1 - 3.9e-05 23.2 0.0 5.1e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFE41711.1 - 0.00074 18.9 0.1 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.9 EFE41711.1 - 0.09 11.5 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DUF1133 PF06576.6 EFE41711.1 - 0.13 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) Peptidase_S32 PF05579.8 EFE41713.1 - 0.0015 17.5 0.0 0.012 14.5 0.0 2.0 2 0 0 2 2 2 1 Equine arteritis virus serine endopeptidase S32 Peptidase_S64 PF08192.6 EFE41713.1 - 0.0095 14.3 0.0 0.013 13.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S64 Trypsin_2 PF13365.1 EFE41713.1 - 0.016 15.1 0.0 0.079 12.9 0.0 2.2 2 1 0 2 2 2 0 Trypsin-like peptidase domain Aa_trans PF01490.13 EFE41714.1 - 8.4e-71 238.5 29.0 1e-70 238.3 20.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein BNIP3 PF06553.7 EFE41714.1 - 0.49 9.7 2.5 0.92 8.8 1.7 1.4 1 0 0 1 1 1 0 BNIP3 Rad52_Rad22 PF04098.10 EFE41716.1 - 8.5e-41 139.2 0.9 2.9e-21 75.8 0.5 2.3 1 1 1 2 2 2 2 Rad52/22 family double-strand break repair protein UBA PF00627.26 EFE41717.1 - 0.01 15.6 0.0 0.041 13.7 0.0 2.1 2 0 0 2 2 2 0 UBA/TS-N domain Herpes_DNAp_acc PF04929.7 EFE41717.1 - 0.014 14.3 0.7 0.014 14.3 0.5 2.2 1 1 1 2 2 2 0 Herpes DNA replication accessory factor zf-C2H2 PF00096.21 EFE41717.1 - 0.016 15.5 0.3 0.03 14.6 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type GATA PF00320.22 EFE41717.1 - 0.04 13.2 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 GATA zinc finger DUF3595 PF12166.3 EFE41717.1 - 0.43 9.3 2.7 0.56 8.9 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) DUF342 PF03961.8 EFE41717.1 - 1.7 6.9 19.3 2.7 6.3 13.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DIT1_PvcA PF05141.7 EFE41717.1 - 2.1 7.6 11.0 3.3 6.9 7.6 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein ArfGap PF01412.13 EFE41717.1 - 2.9 7.7 8.6 1.4 8.7 2.3 2.8 2 1 1 3 3 3 0 Putative GTPase activating protein for Arf DUF2077 PF09850.4 EFE41718.1 - 0.12 11.7 0.1 0.27 10.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2077) Cut8_C PF08559.5 EFE41719.1 - 7.2e-52 175.0 0.0 9.3e-52 174.6 0.0 1.1 1 0 0 1 1 1 1 Cut8 six-helix bundle Cut8_M PF14483.1 EFE41719.1 - 2.8e-13 49.3 0.1 9.6e-13 47.6 0.1 2.0 1 0 0 1 1 1 1 Cut8 dimerisation domain rRNA_proc-arch PF13234.1 EFE41720.1 - 2.7e-103 344.8 0.7 4.1e-103 344.1 0.5 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 EFE41720.1 - 3.6e-36 124.0 0.4 3.6e-36 124.0 0.2 1.8 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.24 EFE41720.1 - 8.6e-22 77.4 0.1 2.6e-21 75.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE41720.1 - 1.2e-06 28.2 0.0 2.7e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE41720.1 - 0.0042 16.9 0.0 0.036 13.8 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SE PF00437.15 EFE41720.1 - 0.028 13.3 0.0 0.065 12.1 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein IKI3 PF04762.7 EFE41721.1 - 0 1031.8 0.0 0 1026.7 0.0 2.0 1 1 0 1 1 1 1 IKI3 family TPR_16 PF13432.1 EFE41721.1 - 0.055 14.1 0.5 0.26 11.9 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3465 PF11948.3 EFE41721.1 - 0.073 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) Apc4_WD40 PF12894.2 EFE41721.1 - 0.14 11.7 0.0 0.55 9.7 0.0 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain GHMP_kinases_N PF00288.21 EFE41722.1 - 1.2e-10 41.2 1.2 2.8e-10 40.1 0.8 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain PDGLE PF13190.1 EFE41722.1 - 0.065 12.9 0.1 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 PDGLE domain Mob1_phocein PF03637.12 EFE41722.1 - 0.19 11.3 0.0 0.46 10.1 0.0 1.5 2 0 0 2 2 2 0 Mob1/phocein family Syntaxin_2 PF14523.1 EFE41723.1 - 6.3e-22 77.5 2.6 6.3e-22 77.5 1.8 2.4 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.14 EFE41723.1 - 2.1e-17 62.5 1.8 2.1e-17 62.5 1.2 2.3 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 EFE41723.1 - 0.00011 22.3 0.2 0.00011 22.3 0.1 2.5 2 1 0 2 2 2 1 Syntaxin Synaptobrevin PF00957.16 EFE41723.1 - 0.00024 20.6 0.9 0.001 18.6 0.2 2.3 2 1 0 2 2 2 1 Synaptobrevin DUF334 PF03904.8 EFE41723.1 - 0.011 15.0 3.5 0.23 10.7 1.0 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF334) DUF552 PF04472.7 EFE41723.1 - 0.012 15.5 0.0 0.13 12.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF552) AAA_13 PF13166.1 EFE41723.1 - 0.025 13.0 6.9 0.035 12.6 4.8 1.2 1 0 0 1 1 1 0 AAA domain Herpes_US9 PF06072.6 EFE41723.1 - 0.036 13.8 0.3 0.069 12.9 0.2 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF883 PF05957.8 EFE41723.1 - 0.043 14.2 10.2 0.47 10.8 0.1 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF912 PF06024.7 EFE41723.1 - 0.11 12.5 0.3 0.33 11.0 0.2 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PBP1_TM PF14812.1 EFE41723.1 - 0.21 11.8 1.5 0.86 9.9 0.0 2.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal T2SF PF00482.18 EFE41723.1 - 0.75 9.7 3.1 0.47 10.3 0.2 2.1 2 2 0 2 2 2 0 Type II secretion system (T2SS), protein F Ndc1_Nup PF09531.5 EFE41724.1 - 8.7e-127 424.0 0.2 9.8e-127 423.8 0.1 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup DUF3984 PF13136.1 EFE41725.1 - 3.2e-91 305.9 15.4 4.3e-90 302.2 10.8 1.9 2 0 0 2 2 2 2 Protein of unknown function (DUF3984) OTCace_N PF02729.16 EFE41726.1 - 6e-42 142.6 0.0 9.4e-42 142.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 EFE41726.1 - 6.8e-41 139.7 0.0 1.2e-40 139.0 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Cu-oxidase_2 PF07731.9 EFE41729.1 - 3.1e-37 127.1 0.8 5.3e-37 126.3 0.6 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.17 EFE41729.1 - 2.5e-09 37.2 0.3 2.8e-08 33.8 0.1 2.4 2 1 0 2 2 2 1 Multicopper oxidase ALS_ss_C PF10369.4 EFE41730.1 - 9.4e-19 66.9 0.0 2.7e-17 62.2 0.0 2.5 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.20 EFE41730.1 - 5.2e-11 41.7 0.1 1e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 EFE41730.1 - 5.4e-09 35.7 0.0 1.2e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.1 EFE41730.1 - 0.019 14.6 0.1 7.1 6.4 0.0 2.6 2 0 0 2 2 2 0 ACT domain KH_1 PF00013.24 EFE41731.1 - 1.9e-07 30.6 0.0 3.9e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 EFE41731.1 - 6.7e-05 22.4 0.2 0.0002 20.9 0.1 1.8 1 0 0 1 1 1 1 KH domain Helicase_C PF00271.26 EFE41732.1 - 6e-18 64.4 0.0 7.6e-15 54.5 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 EFE41732.1 - 0.0015 18.0 0.0 0.0083 15.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase SQS_PSY PF00494.14 EFE41732.1 - 0.081 12.2 0.7 0.15 11.3 0.1 1.6 2 0 0 2 2 2 0 Squalene/phytoene synthase PPR_2 PF13041.1 EFE41733.1 - 4.3e-10 39.4 0.9 0.0059 16.5 0.0 4.7 3 1 1 4 4 4 3 PPR repeat family PPR_3 PF13812.1 EFE41733.1 - 9.7e-10 37.9 1.7 0.29 11.5 0.0 6.1 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR PF01535.15 EFE41733.1 - 2.1e-07 30.4 1.3 0.13 12.3 0.1 4.4 4 0 0 4 4 4 2 PPR repeat MRP-S25 PF13741.1 EFE41734.1 - 7.7e-86 287.2 5.5 9.9e-86 286.9 3.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 SOG2 PF10428.4 EFE41735.1 - 3.3e-100 335.8 1.4 3.3e-100 335.8 1.0 3.1 3 0 0 3 3 3 1 RAM signalling pathway protein LRR_4 PF12799.2 EFE41735.1 - 7.6e-17 60.5 4.9 3.2e-07 29.7 0.7 3.7 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE41735.1 - 1.4e-11 43.9 4.1 1.3e-06 28.1 0.3 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 EFE41735.1 - 2.7e-08 32.7 9.5 0.039 13.9 0.1 6.0 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 EFE41735.1 - 0.0048 16.8 12.0 3.4 8.2 0.1 6.1 6 0 0 6 6 6 1 Leucine rich repeat LRR_6 PF13516.1 EFE41735.1 - 0.0084 16.0 5.5 0.69 10.1 0.1 5.0 4 1 0 4 4 4 1 Leucine Rich repeat ARID PF01388.16 EFE41735.1 - 0.12 12.2 0.1 0.7 9.7 0.0 2.3 2 0 0 2 2 2 0 ARID/BRIGHT DNA binding domain DUF1647 PF07801.6 EFE41735.1 - 0.46 9.9 2.7 1.9 7.9 0.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1647) Peptidase_S10 PF00450.17 EFE41736.1 - 1.2e-77 261.8 0.0 2.4e-77 260.8 0.0 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 EFE41736.1 - 0.011 15.6 0.0 0.13 12.1 0.0 2.2 1 1 0 1 1 1 0 Alpha/beta hydrolase family Tcp11 PF05794.8 EFE41737.1 - 7.1e-79 265.5 0.0 1.3e-78 264.7 0.0 1.4 1 1 0 1 1 1 1 T-complex protein 11 Mito_fiss_reg PF05308.6 EFE41737.1 - 0.73 9.1 8.3 14 4.9 5.0 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator Ydc2-catalyt PF09159.5 EFE41738.1 - 6.7e-92 307.8 0.0 8.4e-92 307.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.8 EFE41738.1 - 5.2e-06 26.3 0.0 0.43 10.4 0.0 3.3 3 0 0 3 3 3 2 Poxvirus A22 protein SAP PF02037.22 EFE41738.1 - 0.00033 20.1 0.5 0.00073 18.9 0.3 1.6 1 0 0 1 1 1 1 SAP domain CTP_transf_2 PF01467.21 EFE41740.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.5 2 0 0 2 2 2 0 Cytidylyltransferase DUF2416 PF10315.4 EFE41741.1 - 0.004 17.3 1.8 0.034 14.3 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2416) DUF2243 PF10002.4 EFE41741.1 - 0.066 12.9 0.3 0.075 12.8 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2243) PMT PF02366.13 EFE41741.1 - 0.12 11.7 0.2 0.13 11.5 0.2 1.0 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF1977 PF09320.6 EFE41742.1 - 1.8e-28 98.8 0.1 3e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.26 EFE41742.1 - 2.3e-23 81.7 0.5 3.9e-23 80.9 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain ADP_ribosyl_GH PF03747.9 EFE41742.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase APH PF01636.18 EFE41743.1 - 9.3e-15 55.0 0.0 1.3e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE41743.1 - 0.0064 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.20 EFE41743.1 - 0.017 14.2 0.0 1.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain Fructosamin_kin PF03881.9 EFE41743.1 - 0.045 12.7 0.0 6.3 5.6 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase EcKinase PF02958.15 EFE41743.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase LRAT PF04970.8 EFE41745.1 - 0.007 16.3 0.6 0.011 15.7 0.1 1.8 2 1 0 2 2 2 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.9 EFE41745.1 - 0.0076 16.0 0.0 0.0096 15.7 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain HTH_10 PF04967.7 EFE41745.1 - 0.045 13.3 0.2 2.3 7.8 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain Ufd2P_core PF10408.4 EFE41746.1 - 1e-185 618.6 14.3 1.2e-185 618.3 9.9 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 EFE41746.1 - 3.1e-28 97.5 1.4 2.8e-27 94.4 0.4 2.7 2 0 0 2 2 2 1 U-box domain Steroid_dh PF02544.11 EFE41747.1 - 2.1e-09 37.2 1.4 0.0025 17.5 0.1 3.6 3 1 0 3 3 3 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 EFE41747.1 - 0.008 15.4 0.3 0.048 12.9 0.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Meth_synt_2 PF01717.13 EFE41748.1 - 1.9e-143 477.3 0.0 8.3e-139 462.0 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 EFE41748.1 - 1.6e-115 385.6 0.0 2.8e-104 348.7 0.0 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.12 EFE41748.1 - 0.0016 17.4 0.0 0.23 10.3 0.0 2.7 3 0 0 3 3 3 2 Uroporphyrinogen decarboxylase (URO-D) LYTB PF02401.13 EFE41748.1 - 0.046 12.6 0.6 5 5.9 0.4 2.2 2 0 0 2 2 2 0 LytB protein DUF2457 PF10446.4 EFE41749.1 - 6.1 5.4 15.2 7.4 5.1 10.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Daxx PF03344.10 EFE41749.1 - 9.3 4.5 6.6 11 4.3 4.6 1.1 1 0 0 1 1 1 0 Daxx Family Myb_DNA-bind_6 PF13921.1 EFE41751.1 - 0.052 13.6 1.0 0.18 11.9 0.0 2.4 3 0 0 3 3 3 0 Myb-like DNA-binding domain V_ATPase_I PF01496.14 EFE41751.1 - 3.8 5.2 12.1 0.094 10.5 3.0 1.8 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family IncA PF04156.9 EFE41751.1 - 7 6.1 10.1 0.097 12.2 1.0 2.1 2 1 0 2 2 2 0 IncA protein 60KD_IMP PF02096.15 EFE41752.1 - 0.015 15.0 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 60Kd inner membrane protein Cnd1_N PF12922.2 EFE41752.1 - 0.032 13.8 1.4 0.044 13.3 1.0 1.2 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term ApbA_C PF08546.6 EFE41753.1 - 6.9e-24 84.2 0.0 1.1e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EFE41753.1 - 1.3e-19 70.1 0.0 1.6e-12 47.1 0.0 2.4 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA Ank_2 PF12796.2 EFE41755.1 - 9.3e-46 154.1 13.0 2.2e-10 40.7 0.0 6.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFE41755.1 - 5.9e-33 112.1 9.4 7.9e-07 29.1 0.1 8.0 4 2 3 7 7 7 7 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE41755.1 - 1.2e-28 98.9 9.5 1.6e-06 28.4 0.0 9.1 5 2 5 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.25 EFE41755.1 - 3.8e-25 86.4 11.8 1.7e-06 27.4 0.0 10.4 11 0 0 11 11 11 6 Ankyrin repeat Ank_3 PF13606.1 EFE41755.1 - 6.4e-21 72.3 3.2 0.00016 21.6 0.0 10.0 10 0 0 10 10 10 3 Ankyrin repeat Saccharop_dh PF03435.13 EFE41755.1 - 0.046 12.7 0.4 0.62 8.9 0.2 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase DEAD PF00270.24 EFE41757.1 - 1.1e-34 119.3 0.0 1.7e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE41757.1 - 6.1e-25 86.8 0.1 2.6e-23 81.6 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE41757.1 - 2.4e-07 30.7 0.0 5.7e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 EFE41757.1 - 0.00044 19.4 0.0 0.0034 16.4 0.0 2.0 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit BNR_2 PF13088.1 EFE41757.1 - 0.059 12.6 0.0 0.088 12.0 0.0 1.2 1 0 0 1 1 1 0 BNR repeat-like domain Rpr2 PF04032.11 EFE41758.1 - 3.6e-23 81.2 0.7 8.6e-23 80.0 0.5 1.6 1 1 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain NAC PF01849.13 EFE41759.1 - 8.3e-23 79.6 0.4 1.6e-22 78.7 0.3 1.5 1 0 0 1 1 1 1 NAC domain Sigma70_ner PF04546.8 EFE41759.1 - 0.46 10.0 3.9 0.95 9.0 0.8 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region adh_short PF00106.20 EFE41760.1 - 2.2e-15 56.9 0.0 1e-13 51.5 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE41760.1 - 1.7e-08 34.3 0.0 3.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE41760.1 - 0.0024 17.6 0.0 0.0036 17.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 EFE41760.1 - 0.0041 16.0 0.0 0.0061 15.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EFE41760.1 - 0.076 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFE41760.1 - 0.14 11.0 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein zf-C2H2 PF00096.21 EFE41761.1 - 4.9e-09 36.0 11.3 0.00037 20.6 1.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFE41761.1 - 9.9e-07 28.7 8.0 6.2e-06 26.2 0.4 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFE41761.1 - 0.00015 21.8 9.8 0.0083 16.3 0.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 EFE41761.1 - 0.0098 16.0 2.9 0.025 14.7 0.8 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-BED PF02892.10 EFE41761.1 - 0.13 11.9 5.5 0.99 9.2 0.2 2.5 2 0 0 2 2 2 0 BED zinc finger Zn-ribbon_8 PF09723.5 EFE41761.1 - 0.14 12.0 1.3 4.1 7.4 0.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2_jaz PF12171.3 EFE41761.1 - 0.33 11.1 5.2 0.64 10.2 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Septin PF00735.13 EFE41764.1 - 1.9e-123 410.9 0.2 1.9e-123 410.9 0.1 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 EFE41764.1 - 7.5e-07 29.1 0.0 1.7e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFE41764.1 - 6.8e-05 22.1 0.3 0.00051 19.2 0.2 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 EFE41764.1 - 0.00019 21.7 4.1 0.023 14.9 0.0 2.9 2 1 0 3 3 3 1 ABC transporter AAA_10 PF12846.2 EFE41764.1 - 0.00049 19.6 1.9 0.0024 17.3 1.2 2.2 1 1 0 1 1 1 1 AAA-like domain GTP_EFTU PF00009.22 EFE41764.1 - 0.0012 18.2 2.1 0.025 14.0 0.0 3.1 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 EFE41764.1 - 0.0015 18.5 0.2 0.016 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain Ras PF00071.17 EFE41764.1 - 0.004 16.5 0.0 0.017 14.5 0.0 2.1 1 1 0 1 1 1 1 Ras family AAA_22 PF13401.1 EFE41764.1 - 0.004 17.2 0.2 0.031 14.4 0.0 2.4 2 2 0 2 2 2 1 AAA domain AIG1 PF04548.11 EFE41764.1 - 0.0043 16.1 0.0 0.0043 16.1 0.0 2.3 2 0 0 2 2 2 1 AIG1 family Miro PF08477.8 EFE41764.1 - 0.0052 17.2 0.4 0.024 15.1 0.0 2.3 3 0 0 3 3 2 1 Miro-like protein AAA_29 PF13555.1 EFE41764.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.12 EFE41764.1 - 0.016 14.7 0.3 1.9 7.9 0.0 2.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.18 EFE41764.1 - 0.019 14.8 7.6 0.52 10.1 0.0 3.7 3 1 0 3 3 2 0 Dynamin family FtsK_SpoIIIE PF01580.13 EFE41764.1 - 0.026 13.9 0.0 0.026 13.9 0.0 2.2 3 0 0 3 3 2 0 FtsK/SpoIIIE family AAA_24 PF13479.1 EFE41764.1 - 0.061 12.8 0.0 0.15 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2937 PF11157.3 EFE41764.1 - 0.11 11.7 4.1 0.24 10.7 2.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) RNA_helicase PF00910.17 EFE41764.1 - 0.13 12.4 0.9 0.88 9.7 0.0 2.4 2 0 0 2 2 2 0 RNA helicase MobB PF03205.9 EFE41764.1 - 0.16 11.6 1.0 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Strep_SA_rep PF06696.6 EFE41764.1 - 0.25 11.1 2.1 0.32 10.7 0.7 1.8 1 1 1 2 2 2 0 Streptococcal surface antigen repeat AAA_32 PF13654.1 EFE41764.1 - 0.33 9.5 14.0 0.59 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Phage_GPO PF05929.6 EFE41764.1 - 0.37 9.9 8.4 0.59 9.3 5.8 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Exonuc_VII_L PF02601.10 EFE41764.1 - 0.69 9.0 12.8 0.85 8.7 8.3 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF87 PF01935.12 EFE41764.1 - 0.94 9.2 5.9 4.1 7.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 DUF342 PF03961.8 EFE41764.1 - 6.2 5.1 9.7 9.9 4.4 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.7 EFE41764.1 - 7.6 5.4 16.1 13 4.7 11.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 UPF0121 PF03661.8 EFE41766.1 - 1.1e-09 37.8 0.6 1.1e-09 37.8 0.4 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0121) FAM176 PF14851.1 EFE41766.1 - 0.0022 17.7 0.0 0.0022 17.7 0.0 2.3 2 1 1 3 3 3 1 FAM176 family Mito_carr PF00153.22 EFE41767.1 - 1.4e-60 200.9 3.7 6.3e-19 67.4 0.3 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein CHCH PF06747.8 EFE41769.1 - 1.1e-06 28.4 5.3 1.8e-06 27.6 3.6 1.4 1 0 0 1 1 1 1 CHCH domain GCK PF07802.6 EFE41769.1 - 0.02 14.9 1.4 0.049 13.7 1.0 1.7 1 0 0 1 1 1 0 GCK domain TPK_B1_binding PF04265.9 EFE41770.1 - 2e-18 65.8 0.0 3.4e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TPK_catalytic PF04263.11 EFE41770.1 - 5.2e-16 58.3 0.1 3.5e-15 55.6 0.1 1.9 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain MIF4G PF02854.14 EFE41772.1 - 1.1e-57 194.8 0.0 6.3e-29 100.8 0.0 3.7 4 0 0 4 4 4 2 MIF4G domain Upf2 PF04050.9 EFE41772.1 - 1.1e-52 178.2 19.8 1.1e-52 178.2 13.7 2.6 2 0 0 2 2 2 1 Up-frameshift suppressor 2 FliD_C PF07195.7 EFE41772.1 - 0.0058 15.9 1.7 0.011 14.9 1.2 1.4 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus Pyr_redox_3 PF13738.1 EFE41774.1 - 9.2e-25 87.9 0.0 1.7e-23 83.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFE41774.1 - 5.2e-16 57.9 0.1 3.8e-14 51.8 0.1 2.5 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFE41774.1 - 5.5e-09 35.9 0.0 1.2e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFE41774.1 - 8.7e-07 29.0 0.0 9.5e-06 25.6 0.0 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE41774.1 - 1.1e-06 27.8 0.1 0.00023 20.1 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 EFE41774.1 - 0.00017 20.6 0.0 0.00066 18.6 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFE41774.1 - 0.0018 18.0 0.0 0.021 14.6 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 EFE41774.1 - 0.0052 15.9 0.3 0.0093 15.0 0.2 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 EFE41774.1 - 0.018 13.8 0.3 0.027 13.3 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.15 EFE41774.1 - 0.052 13.6 0.3 8.1 6.5 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.9 EFE41774.1 - 0.46 8.9 1.4 0.81 8.0 1.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Glyco_hydro_18 PF00704.23 EFE41775.1 - 1.1e-78 265.0 0.1 1.5e-78 264.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.15 EFE41775.1 - 2.4e-12 46.5 0.0 4.6e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 LysM domain Glyco_transf_8 PF01501.15 EFE41777.1 - 9.5e-10 38.2 0.1 1.2e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 APH PF01636.18 EFE41778.1 - 3.5e-16 59.6 0.0 8.3e-16 58.4 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE41778.1 - 0.00055 18.6 0.0 0.18 10.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) SUN PF03856.8 EFE41779.1 - 6e-88 294.3 3.8 8e-88 293.9 2.7 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF605 PF04652.11 EFE41779.1 - 3.4 6.9 14.5 4.6 6.5 10.0 1.1 1 0 0 1 1 1 0 Vta1 like Fer4_10 PF13237.1 EFE41779.1 - 4 7.3 6.8 0.15 11.8 0.3 1.9 2 0 0 2 2 2 0 4Fe-4S dicluster domain Ribosomal_L1 PF00687.16 EFE41780.1 - 1.2e-50 171.8 0.1 1.2e-50 171.8 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family DUF4220 PF13968.1 EFE41780.1 - 0.23 10.5 0.5 0.33 10.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF2228 PF10228.4 EFE41780.1 - 1.8 8.0 6.1 8.3 5.8 3.8 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) ETF PF01012.16 EFE41781.1 - 4.5e-38 130.5 0.6 9.3e-38 129.5 0.4 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.14 EFE41781.1 - 1.2e-34 117.7 0.1 2.4e-34 116.8 0.1 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Kdo PF06293.9 EFE41782.1 - 1.5e-05 24.1 0.0 3.3e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EFE41782.1 - 1.8e-05 24.0 0.0 5e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFE41782.1 - 5.3e-05 23.0 0.1 5.3e-05 23.0 0.1 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EFE41782.1 - 0.0027 17.0 0.0 0.0075 15.6 0.0 1.8 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 EFE41782.1 - 0.029 13.7 0.0 0.078 12.3 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 EFE41782.1 - 0.046 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase CarD_CdnL_TRCF PF02559.11 EFE41782.1 - 0.12 12.4 0.9 0.96 9.5 0.0 2.5 2 0 0 2 2 2 0 CarD-like/TRCF domain Macoilin PF09726.4 EFE41782.1 - 1.2 7.3 6.4 2.8 6.0 4.5 1.5 1 0 0 1 1 1 0 Transmembrane protein PglZ PF08665.7 EFE41783.1 - 0.47 10.0 3.5 2.1 8.0 0.5 2.0 1 1 1 2 2 2 0 PglZ domain KAR9 PF08580.5 EFE41783.1 - 2.7 6.1 11.3 2.9 6.0 7.8 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 AAA PF00004.24 EFE41784.1 - 7e-12 45.6 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFE41784.1 - 6.8e-06 25.8 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EFE41784.1 - 9.3e-06 24.8 0.0 2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFE41784.1 - 3.1e-05 24.1 0.0 7.3e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 EFE41784.1 - 7e-05 21.7 0.0 0.00011 21.0 0.0 1.3 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 EFE41784.1 - 0.00012 21.7 0.1 0.00012 21.7 0.1 2.7 3 0 0 3 3 2 1 Part of AAA domain AAA_14 PF13173.1 EFE41784.1 - 0.00016 21.5 0.0 0.0003 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFE41784.1 - 0.00043 19.4 0.0 0.001 18.1 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 EFE41784.1 - 0.00047 20.9 0.1 0.0023 18.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE41784.1 - 0.0017 18.2 0.0 0.0044 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE41784.1 - 0.0075 16.2 0.0 0.035 14.0 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 EFE41784.1 - 0.029 14.6 0.1 0.071 13.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 EFE41784.1 - 0.034 13.8 0.1 0.073 12.7 0.1 1.6 1 0 0 1 1 1 0 NTPase DUF1776 PF08643.5 EFE41784.1 - 0.048 12.7 0.0 0.077 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF258 PF03193.11 EFE41784.1 - 0.085 12.0 0.0 0.085 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Baculo_PEP_C PF04513.7 EFE41785.1 - 0.0072 16.1 5.4 0.73 9.6 3.8 2.4 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus BBP1_C PF15272.1 EFE41785.1 - 0.008 15.7 0.7 0.016 14.7 0.5 1.5 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal DUF4631 PF15450.1 EFE41785.1 - 0.0085 14.4 3.9 0.012 13.9 2.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4631) Allexi_40kDa PF05549.6 EFE41785.1 - 0.011 15.0 3.8 0.23 10.7 0.2 2.3 1 1 0 2 2 2 0 Allexivirus 40kDa protein DASH_Dad1 PF08649.5 EFE41785.1 - 0.012 15.2 0.5 1 9.0 0.0 2.5 2 0 0 2 2 2 0 DASH complex subunit Dad1 Reo_sigmaC PF04582.7 EFE41785.1 - 0.069 12.3 5.5 0.13 11.3 3.5 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein LXG PF04740.7 EFE41785.1 - 0.084 12.6 6.5 0.65 9.7 0.5 3.1 2 1 1 3 3 3 0 LXG domain of WXG superfamily ATG16 PF08614.6 EFE41785.1 - 0.085 12.6 4.3 0.11 12.2 0.7 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.2 EFE41785.1 - 0.54 10.1 4.2 3.3 7.5 0.1 2.6 1 1 0 2 2 2 0 Tropomyosin like Uds1 PF15456.1 EFE41785.1 - 0.54 10.2 4.4 0.75 9.8 1.4 2.3 1 1 1 2 2 2 0 Up-regulated During Septation Bacillus_HBL PF05791.6 EFE41785.1 - 0.61 9.4 7.4 0.58 9.4 0.4 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Matrilin_ccoil PF10393.4 EFE41785.1 - 0.63 9.4 4.0 1.8 8.0 0.0 3.3 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Tropomyosin PF00261.15 EFE41785.1 - 1.1 8.2 6.4 0.69 8.9 1.2 2.1 1 1 1 2 2 2 0 Tropomyosin SWIRM PF04433.12 EFE41786.1 - 1.9e-33 114.4 0.0 4.4e-33 113.2 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.26 EFE41786.1 - 3.2e-07 30.2 0.1 6.1e-07 29.4 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE41786.1 - 2.5e-05 24.2 0.1 6.8e-05 22.8 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.12 EFE41786.1 - 0.028 13.9 0.0 0.028 13.9 0.0 2.1 2 0 0 2 2 2 0 Zinc finger, ZZ type DUF2217 PF10265.4 EFE41786.1 - 0.88 8.2 7.2 1.6 7.3 5.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Vfa1 PF08432.5 EFE41786.1 - 7.7 6.4 19.2 3.7 7.5 5.4 3.2 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 ResIII PF04851.10 EFE41788.1 - 4e-18 65.8 0.1 8.2e-17 61.6 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EFE41788.1 - 3.6e-13 49.1 0.0 7.8e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE41788.1 - 2.9e-07 30.1 0.0 3.7e-05 23.2 0.0 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFE41788.1 - 0.098 12.8 0.1 0.32 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 EFE41788.1 - 0.11 11.7 0.1 0.66 9.2 0.0 2.0 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain Ank_2 PF12796.2 EFE41790.1 - 4.7e-41 139.0 0.1 5.3e-15 55.5 0.1 4.3 4 0 0 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EFE41790.1 - 1.3e-30 103.6 13.1 1.4e-06 27.7 0.2 8.5 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.1 EFE41790.1 - 1.4e-26 92.3 8.3 6.9e-08 32.8 0.0 6.6 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE41790.1 - 2.9e-25 85.8 2.8 0.0027 17.8 0.0 8.5 8 1 1 9 9 9 7 Ankyrin repeat Ank_5 PF13857.1 EFE41790.1 - 1.1e-22 79.5 6.1 0.00023 21.3 0.1 7.9 3 2 5 8 8 8 5 Ankyrin repeats (many copies) RVP PF00077.15 EFE41790.1 - 0.02 14.8 0.0 11 6.0 0.0 3.0 3 0 0 3 3 3 0 Retroviral aspartyl protease DUF3447 PF11929.3 EFE41790.1 - 0.053 13.3 0.2 2.4 8.0 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF3447) DUF3700 PF12481.3 EFE41790.1 - 0.093 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Aluminium induced protein Glyco_transf_90 PF05686.7 EFE41792.1 - 4.9e-27 94.6 0.9 6.6e-27 94.2 0.6 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 EFE41792.1 - 0.0074 16.5 0.1 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 PGAP1 PF07819.8 EFE41793.1 - 2.2e-79 266.1 0.0 3.6e-79 265.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 EFE41793.1 - 3.8e-06 26.7 0.1 2.6e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE41793.1 - 0.00012 22.0 0.1 0.00012 22.0 0.1 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE41793.1 - 0.0004 19.9 0.0 0.001 18.6 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 EFE41793.1 - 0.0024 17.3 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase LCAT PF02450.10 EFE41793.1 - 0.011 14.7 0.0 0.018 14.0 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF676 PF05057.9 EFE41793.1 - 0.019 14.2 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Peptidase_M28 PF04389.12 EFE41794.1 - 1.5e-25 89.9 0.2 3.8e-25 88.6 0.2 1.6 1 1 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EFE41794.1 - 5e-06 26.1 0.0 7.7e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 EFE41794.1 - 0.00025 19.9 0.0 0.00059 18.7 0.0 1.7 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase fn3 PF00041.16 EFE41794.1 - 0.01 15.9 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain 4_1_CTD PF05902.8 EFE41794.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) Nicastrin PF05450.10 EFE41794.1 - 0.086 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Nicastrin NAD_binding_10 PF13460.1 EFE41795.1 - 1.7e-08 34.7 0.0 5.5e-08 33.0 0.0 1.9 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFE41795.1 - 0.00018 20.8 0.1 0.00033 20.0 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family KR PF08659.5 EFE41795.1 - 0.084 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 KR domain APG17 PF04108.7 EFE41797.1 - 2.9e-115 385.3 0.1 3.4e-115 385.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Tweety PF04906.8 EFE41797.1 - 0.029 12.7 1.1 0.18 10.1 0.0 2.4 3 0 0 3 3 3 0 Tweety DUF1542 PF07564.6 EFE41797.1 - 0.049 13.6 0.4 0.049 13.6 0.3 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) HTH_11 PF08279.7 EFE41797.1 - 0.2 11.3 1.1 4.2 7.0 0.0 2.8 2 1 0 2 2 2 0 HTH domain WD40 PF00400.27 EFE41798.1 - 2.4e-63 207.8 17.8 4e-11 42.3 0.3 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.2 EFE41798.1 - 1.6e-14 53.2 0.4 3.6e-14 52.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE41798.1 - 9.7e-11 41.0 0.3 2.5e-10 39.7 0.1 1.9 1 1 1 2 2 2 1 F-box domain Nup160 PF11715.3 EFE41798.1 - 7.4e-10 37.5 11.1 0.0007 17.8 0.5 5.0 2 2 2 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFE41798.1 - 0.04 12.6 2.3 2.8 6.6 0.3 2.7 1 1 1 2 2 2 0 Nup133 N terminal like PRANC PF09372.5 EFE41798.1 - 0.041 13.8 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 PRANC domain RIO1 PF01163.17 EFE41802.1 - 1.3e-72 243.1 0.1 1.3e-72 243.1 0.1 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 EFE41802.1 - 1.6e-06 28.0 0.3 0.00057 19.6 0.1 2.5 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EFE41802.1 - 0.0002 20.4 0.3 0.0024 16.9 0.2 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE41802.1 - 0.05 13.1 1.0 0.099 12.1 0.1 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF3464 PF11947.3 EFE41802.1 - 0.092 12.2 1.7 0.22 10.9 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) SMC_hinge PF06470.8 EFE41803.1 - 3.6e-33 114.0 0.1 2.2e-32 111.5 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.14 EFE41803.1 - 4.6e-29 101.2 24.4 1e-28 100.0 16.9 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFE41803.1 - 3.8e-10 40.4 25.6 3.8e-10 40.4 17.7 6.7 2 2 3 5 5 5 1 AAA domain AAA_21 PF13304.1 EFE41803.1 - 3.1e-06 27.3 4.1 3.8e-06 27.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 EFE41803.1 - 0.00028 20.3 0.0 0.00065 19.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.1 EFE41803.1 - 0.0014 17.2 87.7 0.0027 16.2 17.3 5.6 3 2 1 5 5 5 3 AAA domain Reo_sigmaC PF04582.7 EFE41803.1 - 0.0048 16.1 23.5 0.69 9.0 0.7 4.9 3 1 0 4 4 4 4 Reovirus sigma C capsid protein FtsK_SpoIIIE PF01580.13 EFE41803.1 - 0.23 10.9 0.0 0.23 10.9 0.0 4.0 4 1 0 4 4 4 0 FtsK/SpoIIIE family ABC_tran PF00005.22 EFE41803.1 - 0.36 11.1 0.0 0.36 11.1 0.0 6.1 4 2 0 4 4 4 0 ABC transporter DUF3605 PF12239.3 EFE41804.1 - 2.7e-54 183.3 0.0 3.1e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Dfp1_Him1_M PF08630.5 EFE41804.1 - 0.038 13.7 0.0 0.51 10.1 0.0 2.1 2 0 0 2 2 2 0 Dfp1/Him1, central region FAD_binding_6 PF00970.19 EFE41805.1 - 7.4e-29 99.7 0.0 1.2e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EFE41805.1 - 3.2e-27 95.2 0.0 5.1e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EFE41805.1 - 1.2e-05 25.2 0.0 0.0013 18.6 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 EFE41805.1 - 0.0021 18.0 0.0 0.0044 16.9 0.0 1.6 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain DUF4176 PF13780.1 EFE41805.1 - 0.038 13.6 0.0 0.09 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) WD40 PF00400.27 EFE41806.1 - 2.8e-17 61.8 19.4 3.6e-06 26.6 0.9 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat DUF4145 PF13643.1 EFE41806.1 - 0.086 12.6 0.3 0.23 11.3 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) tRNA-synt_1d PF00750.14 EFE41807.1 - 1e-76 258.0 8.8 2e-41 142.0 5.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.10 EFE41807.1 - 1.2e-27 96.2 0.0 3e-27 94.9 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 EFE41807.1 - 0.0035 17.8 1.5 0.0083 16.6 0.0 2.4 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain NPV_P10 PF05531.7 EFE41807.1 - 0.18 12.0 2.0 0.25 11.6 0.3 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF904 PF06005.7 EFE41811.1 - 0.05 13.9 3.4 23 5.3 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF904) Dabb PF07876.7 EFE41812.1 - 3.9e-23 81.7 0.1 5e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain HAMP PF00672.20 EFE41812.1 - 0.17 12.0 1.7 0.31 11.2 1.2 1.3 1 0 0 1 1 1 0 HAMP domain NAD_binding_1 PF00175.16 EFE41813.1 - 1.2e-21 77.2 0.0 1.5e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EFE41813.1 - 4.4e-07 29.9 0.0 0.00053 19.9 0.0 2.1 2 0 0 2 2 2 2 Ferric reductase NAD binding domain DUF1206 PF06724.6 EFE41814.1 - 0.061 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) SR-25 PF10500.4 EFE41815.1 - 0.63 9.4 5.1 0.69 9.3 3.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_1 PF07690.11 EFE41816.1 - 3.2e-34 118.2 15.9 6.2e-33 113.9 10.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE41816.1 - 6.6e-10 38.1 3.0 1.4e-09 37.1 2.1 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter Abhydrolase_6 PF12697.2 EFE41817.1 - 3.9e-31 108.6 0.6 5.2e-31 108.2 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE41817.1 - 2.4e-08 33.8 0.1 5e-08 32.8 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family WD40 PF00400.27 EFE41818.1 - 4.6e-25 86.5 17.9 5.7e-09 35.5 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat DUF1014 PF06244.7 EFE41819.1 - 1.4e-23 83.4 13.7 5.1e-23 81.5 9.5 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) Toprim_4 PF13662.1 EFE41819.1 - 0.025 14.5 0.0 0.079 12.9 0.0 1.9 1 0 0 1 1 1 0 Toprim domain U79_P34 PF03064.11 EFE41819.1 - 0.23 10.9 9.8 0.44 10.0 6.8 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 F-box-like PF12937.2 EFE41820.1 - 2.7e-07 30.1 0.3 5.5e-07 29.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE41820.1 - 7.2e-07 28.6 0.5 7.2e-07 28.6 0.4 2.7 3 0 0 3 3 3 1 F-box domain Mito_fiss_reg PF05308.6 EFE41820.1 - 6.1 6.1 15.0 0.065 12.5 0.7 2.7 3 0 0 3 3 3 0 Mitochondrial fission regulator Peptidase_C13 PF01650.13 EFE41821.1 - 4.3e-41 140.8 0.0 6.3e-41 140.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase C13 family CDC45 PF02724.9 EFE41822.1 - 1.1e-231 770.2 0.0 2.9e-231 768.8 0.0 2.1 1 1 0 1 1 1 1 CDC45-like protein BUD22 PF09073.5 EFE41822.1 - 0.49 9.4 31.4 0.64 9.0 4.0 2.1 2 0 0 2 2 2 0 BUD22 DUF3513 PF12026.3 EFE41822.1 - 0.54 9.7 4.7 0.95 8.9 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) DDRGK PF09756.4 EFE41822.1 - 1.4 8.3 15.9 2.4 7.5 11.0 1.3 1 0 0 1 1 1 0 DDRGK domain FAM60A PF15396.1 EFE41822.1 - 3.8 7.1 8.3 0.12 12.1 1.4 1.6 2 0 0 2 2 2 0 Protein Family FAM60A NPR3 PF03666.8 EFE41822.1 - 4.1 5.8 9.4 8.7 4.7 6.5 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ycf1 PF05758.7 EFE41822.1 - 5.1 4.6 5.7 7.4 4.1 3.9 1.1 1 0 0 1 1 1 0 Ycf1 Trypan_PARP PF05887.6 EFE41822.1 - 7.8 6.3 12.6 0.91 9.3 3.6 2.7 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) Acetyltransf_1 PF00583.19 EFE41823.1 - 1.1e-08 35.0 0.0 1.7e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE41823.1 - 2.6e-07 30.7 0.0 4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE41823.1 - 6.9e-06 26.1 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE41823.1 - 1.8e-05 24.4 0.0 3.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 EFE41823.1 - 0.00024 20.9 0.2 0.1 12.4 0.0 2.3 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Condensation PF00668.15 EFE41824.1 - 6.3e-11 41.6 0.0 8.6e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 Condensation domain EBP PF05241.7 EFE41825.1 - 0.11 11.5 2.9 0.15 11.0 1.7 1.4 1 1 0 1 1 1 0 Emopamil binding protein ABC_tran PF00005.22 EFE41826.1 - 3e-47 160.3 0.4 2e-25 89.7 0.1 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFE41826.1 - 1.3e-29 103.5 32.2 1e-25 90.6 11.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.1 EFE41826.1 - 2.9e-12 47.1 4.3 0.011 15.7 0.0 4.3 3 1 1 4 4 4 3 AAA domain SMC_N PF02463.14 EFE41826.1 - 6.5e-09 35.3 6.7 0.0016 17.6 0.1 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EFE41826.1 - 3.9e-07 29.5 0.3 0.0032 16.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EFE41826.1 - 6.4e-07 29.8 0.3 0.00047 20.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFE41826.1 - 1.9e-06 27.1 0.2 0.0014 17.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 EFE41826.1 - 2e-06 27.4 0.3 0.0081 15.6 0.0 2.5 2 0 0 2 2 2 2 AAA-like domain AAA_16 PF13191.1 EFE41826.1 - 1.1e-05 25.4 1.9 0.03 14.2 0.1 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 EFE41826.1 - 1.4e-05 24.6 0.1 0.036 13.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFE41826.1 - 4.6e-05 23.3 0.1 0.09 12.7 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 EFE41826.1 - 0.00021 21.7 0.3 0.82 10.1 0.1 2.6 2 0 0 2 2 2 2 Miro-like protein AAA_22 PF13401.1 EFE41826.1 - 0.00043 20.4 2.6 0.36 10.9 0.0 3.3 2 1 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 EFE41826.1 - 0.00046 19.9 0.0 0.048 13.3 0.0 2.7 2 0 0 2 2 2 1 Archaeal ATPase AAA PF00004.24 EFE41826.1 - 0.00079 19.6 1.4 0.089 12.9 0.1 3.4 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EFE41826.1 - 0.00089 18.4 0.2 0.7 8.9 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin T2SE PF00437.15 EFE41826.1 - 0.002 17.1 0.5 0.065 12.1 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_17 PF13207.1 EFE41826.1 - 0.0026 18.5 0.3 0.68 10.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EFE41826.1 - 0.0032 17.3 0.2 0.15 11.9 0.0 3.1 3 0 0 3 3 2 1 AAA domain Viral_helicase1 PF01443.13 EFE41826.1 - 0.0041 16.6 0.6 0.47 9.9 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ArgK PF03308.11 EFE41826.1 - 0.0041 15.9 0.9 0.9 8.2 0.0 2.4 2 0 0 2 2 2 1 ArgK protein DUF815 PF05673.8 EFE41826.1 - 0.0046 15.9 0.2 0.52 9.1 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.13 EFE41826.1 - 0.0052 16.2 0.1 0.52 9.7 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family Dynamin_N PF00350.18 EFE41826.1 - 0.0064 16.3 1.7 0.089 12.6 0.0 2.6 3 0 0 3 3 2 1 Dynamin family RNA_helicase PF00910.17 EFE41826.1 - 0.009 16.1 0.2 1.9 8.7 0.0 3.2 3 0 0 3 3 2 1 RNA helicase Adeno_IVa2 PF02456.10 EFE41826.1 - 0.011 14.3 0.1 0.049 12.2 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein NB-ARC PF00931.17 EFE41826.1 - 0.014 14.2 3.1 0.1 11.4 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain AAA_18 PF13238.1 EFE41826.1 - 0.018 15.3 0.3 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 EFE41826.1 - 0.02 14.3 0.2 3 7.2 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.1 EFE41826.1 - 0.044 13.5 1.5 0.39 10.5 0.0 3.0 3 0 0 3 3 3 0 Part of AAA domain AAA_33 PF13671.1 EFE41826.1 - 0.046 13.6 0.6 2.3 8.0 0.0 2.8 3 0 0 3 3 2 0 AAA domain MobB PF03205.9 EFE41826.1 - 0.049 13.3 3.8 3.9 7.1 0.5 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.10 EFE41826.1 - 0.071 12.8 2.7 6.3 6.4 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.1 EFE41826.1 - 0.071 12.6 0.7 15 5.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain ABC_ATPase PF09818.4 EFE41826.1 - 0.088 11.3 2.4 1.3 7.5 0.1 2.9 3 0 0 3 3 3 0 Predicted ATPase of the ABC class cobW PF02492.14 EFE41826.1 - 0.1 12.0 6.4 0.39 10.1 0.6 3.0 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Herpes_Helicase PF02689.9 EFE41826.1 - 0.18 9.5 0.1 8.2 4.0 0.0 2.1 2 0 0 2 2 2 0 Helicase DUF87 PF01935.12 EFE41826.1 - 0.44 10.3 3.9 1.2 8.9 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_24 PF13479.1 EFE41826.1 - 1 8.9 2.3 3.1 7.3 0.2 2.3 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 EFE41826.1 - 2.2 7.6 7.1 16 4.8 0.1 4.0 4 0 0 4 4 4 0 IstB-like ATP binding protein NACHT PF05729.7 EFE41826.1 - 4.3 6.9 9.8 0.54 9.9 0.5 3.3 3 0 0 3 3 3 0 NACHT domain Fungal_trans_2 PF11951.3 EFE41827.1 - 2.6e-48 164.5 0.3 8.9e-48 162.7 0.2 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE41827.1 - 9.8e-05 22.1 5.4 0.0002 21.2 3.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trypan_PARP PF05887.6 EFE41829.1 - 0.11 12.3 3.7 0.14 11.9 2.6 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NPR3 PF03666.8 EFE41829.1 - 1.7 7.1 11.1 1.9 6.9 7.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2992 PF11208.3 EFE41829.1 - 4.3 7.2 15.7 6 6.7 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) DDHD PF02862.12 EFE41829.1 - 5.1 6.8 11.8 6.4 6.5 8.2 1.1 1 0 0 1 1 1 0 DDHD domain MFS_1 PF07690.11 EFE41830.1 - 2.8e-30 105.2 22.6 2.8e-30 105.2 15.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily adh_short PF00106.20 EFE41831.1 - 3.4e-08 33.5 0.0 4e-08 33.3 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE41831.1 - 0.00013 21.6 0.0 0.00016 21.3 0.0 1.0 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE41831.1 - 0.0067 16.2 0.0 0.0076 16.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.8 EFE41831.1 - 0.014 14.6 0.1 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 NmrA-like family DUF460 PF04312.8 EFE41831.1 - 0.036 13.6 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF460) Amino_oxidase PF01593.19 EFE41832.1 - 2.6e-58 198.1 0.5 1.1e-52 179.6 0.1 2.1 1 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EFE41832.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain BPS PF08947.5 EFE41835.1 - 0.083 12.5 2.8 0.097 12.3 0.7 2.0 1 1 1 2 2 2 0 BPS (Between PH and SH2) MRP-L28 PF09812.4 EFE41835.1 - 2.8 7.7 6.5 9.2 6.0 3.9 2.0 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L28 FoP_duplication PF13865.1 EFE41836.1 - 4.9e-06 26.8 0.8 8.3e-06 26.1 0.6 1.3 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.17 EFE41836.1 - 9.3e-05 21.9 0.0 0.00016 21.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41836.1 - 0.00091 19.1 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41836.1 - 0.0011 18.7 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_60s PF00428.14 EFE41836.1 - 3.4 8.1 7.5 5.9 7.3 1.8 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Hc1 PF07432.8 EFE41837.1 - 0.27 11.4 3.5 0.31 11.2 2.4 1.1 1 0 0 1 1 1 0 Histone H1-like protein Hc1 Ank_2 PF12796.2 EFE41838.1 - 1.3e-91 301.0 1.8 3.9e-21 75.1 0.0 7.8 4 2 4 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.25 EFE41838.1 - 3.8e-73 237.8 11.8 7.9e-09 34.9 0.0 15.4 16 0 0 16 16 16 12 Ankyrin repeat Ank_4 PF13637.1 EFE41838.1 - 8.8e-62 204.4 4.4 7.3e-13 48.6 0.0 11.1 7 2 6 13 13 12 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE41838.1 - 2.1e-59 191.5 3.4 3.2e-06 26.8 0.0 16.9 18 0 0 18 18 16 10 Ankyrin repeat Ank_5 PF13857.1 EFE41838.1 - 6.9e-50 165.9 6.7 8.6e-10 38.5 0.0 14.7 3 2 12 16 16 16 10 Ankyrin repeats (many copies) HeLo PF14479.1 EFE41838.1 - 5.4e-27 94.9 0.0 1.1e-26 93.9 0.0 1.5 1 0 0 1 1 1 1 Prion-inhibition and propagation NACHT PF05729.7 EFE41838.1 - 3.1e-08 33.4 0.0 6.7e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EFE41838.1 - 4.9e-06 26.7 0.0 1.8e-05 24.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE41838.1 - 1e-05 25.6 0.0 4.2e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.17 EFE41838.1 - 2.8e-05 23.1 0.0 5.4e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain RNA_helicase PF00910.17 EFE41838.1 - 0.0028 17.7 0.0 0.007 16.5 0.0 1.7 1 0 0 1 1 1 1 RNA helicase MobB PF03205.9 EFE41838.1 - 0.0029 17.2 0.0 0.01 15.5 0.0 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 EFE41838.1 - 0.029 14.0 0.0 0.082 12.5 0.0 1.8 1 0 0 1 1 1 0 Archaeal ATPase Sigma54_activ_2 PF14532.1 EFE41838.1 - 0.076 13.0 0.1 7.3 6.6 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF1843 PF08898.5 EFE41838.1 - 0.078 13.0 2.1 28 4.8 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) AAA_10 PF12846.2 EFE41838.1 - 0.096 12.1 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA-like domain Shigella_OspC PF06128.6 EFE41838.1 - 0.11 11.9 0.0 37 3.6 0.0 3.5 3 1 1 4 4 4 0 Shigella flexneri OspC protein AAA_33 PF13671.1 EFE41838.1 - 0.12 12.2 0.0 0.36 10.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 EFE41838.1 - 0.15 11.5 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Glyco_hydro_72 PF03198.9 EFE41839.1 - 2.8e-109 364.9 0.3 3.8e-109 364.4 0.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 EFE41839.1 - 1.4e-05 24.4 0.0 0.00034 19.9 0.0 2.2 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MAS20 PF02064.10 EFE41840.1 - 2.4e-07 30.6 0.0 3e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor Vps51 PF08700.6 EFE41841.1 - 6.1e-16 58.0 1.9 6.1e-16 58.0 1.3 2.1 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.6 EFE41841.1 - 6.8e-05 22.7 0.2 6.8e-05 22.7 0.1 2.6 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Sec5 PF15469.1 EFE41841.1 - 0.16 11.6 3.9 2.1 8.0 0.0 3.0 3 0 0 3 3 3 0 Exocyst complex component Sec5 Baculo_PEP_C PF04513.7 EFE41841.1 - 2.4 7.9 5.6 0.67 9.7 0.4 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran PF00005.22 EFE41842.1 - 6.3e-21 75.1 0.0 6.8e-10 39.3 0.0 2.9 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFE41842.1 - 2.1e-08 34.5 0.9 0.00018 21.6 0.0 2.7 3 0 0 3 3 3 2 AAA domain SbcCD_C PF13558.1 EFE41842.1 - 9.2e-05 22.2 0.0 0.032 14.1 0.0 2.6 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 EFE41842.1 - 0.13 12.3 0.0 3 7.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain DUF3584 PF12128.3 EFE41842.1 - 0.23 8.7 0.0 0.39 7.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_23 PF13476.1 EFE41842.1 - 0.26 11.5 0.8 0.55 10.5 0.6 1.5 1 0 0 1 1 1 0 AAA domain CPSase_L_D2 PF02786.12 EFE41843.1 - 2.8e-114 379.6 0.2 7.7e-83 276.9 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 EFE41843.1 - 5e-47 158.6 0.0 1.1e-46 157.5 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 EFE41843.1 - 2.1e-45 154.5 0.0 1e-44 152.3 0.0 2.2 3 0 0 3 3 3 1 Glutamine amidotransferase class-I OTCace_N PF02729.16 EFE41843.1 - 1.3e-42 144.8 0.0 2.5e-42 143.8 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.14 EFE41843.1 - 2.3e-40 137.1 0.0 5e-40 136.0 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_L_chain PF00289.17 EFE41843.1 - 6.2e-40 135.7 0.0 1.7e-18 66.7 0.0 3.0 3 0 0 3 3 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 EFE41843.1 - 4.8e-36 124.2 0.3 9.3e-23 80.9 0.0 2.7 3 0 0 3 3 3 2 ATP-grasp domain OTCace PF00185.19 EFE41843.1 - 6.1e-29 100.9 0.0 1.8e-28 99.4 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.17 EFE41843.1 - 7.7e-23 80.2 0.0 3.9e-22 77.9 0.0 2.4 1 0 0 1 1 1 1 MGS-like domain ATPgrasp_Ter PF15632.1 EFE41843.1 - 3.7e-22 78.5 0.1 2.8e-10 39.4 0.0 4.2 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EFE41843.1 - 5.3e-16 58.6 0.2 2.7e-08 33.4 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 EFE41843.1 - 4.9e-15 55.2 0.1 4.5e-07 29.3 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_3 PF02655.9 EFE41843.1 - 2.1e-06 27.6 0.4 0.022 14.6 0.0 2.9 3 0 0 3 3 3 2 ATP-grasp domain RimK PF08443.6 EFE41843.1 - 4.5e-06 26.2 0.0 0.0011 18.4 0.0 2.7 2 0 0 2 2 2 1 RimK-like ATP-grasp domain Peptidase_C26 PF07722.8 EFE41843.1 - 1.1e-05 24.9 0.1 0.00029 20.3 0.1 2.6 1 1 0 1 1 1 1 Peptidase C26 GARS_A PF01071.14 EFE41843.1 - 0.014 14.9 0.0 3.4 7.1 0.0 2.8 2 1 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DJ-1_PfpI PF01965.19 EFE41843.1 - 0.032 13.7 0.0 0.082 12.3 0.0 1.6 1 0 0 1 1 1 0 DJ-1/PfpI family Git3_C PF11970.3 EFE41844.1 - 0.064 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF4231 PF14015.1 EFE41844.1 - 0.73 9.8 5.1 4.5 7.2 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) Ion_trans PF00520.26 EFE41845.1 - 4.9e-06 25.9 24.3 2.2e-05 23.8 16.9 2.0 1 1 0 1 1 1 1 Ion transport protein Synaptobrevin PF00957.16 EFE41846.1 - 2.1e-32 110.5 0.0 2.5e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 Synaptobrevin DUF2628 PF10947.3 EFE41846.1 - 0.087 12.6 1.7 0.14 11.9 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Longin PF13774.1 EFE41846.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Regulated-SNARE-like domain KOW PF00467.24 EFE41847.1 - 2.1e-08 33.5 2.1 2.1e-08 33.5 1.5 1.7 2 0 0 2 2 2 1 KOW motif YkyA PF10368.4 EFE41848.1 - 0.0076 15.6 0.7 0.015 14.6 0.5 1.4 1 0 0 1 1 1 1 Putative cell-wall binding lipoprotein zf-CCCH PF00642.19 EFE41849.1 - 0.00013 21.5 1.2 0.00013 21.5 0.8 2.7 3 1 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Snf7 PF03357.16 EFE41851.1 - 3.9e-20 71.9 15.0 4.4e-20 71.7 8.5 1.9 1 1 1 2 2 2 1 Snf7 DUF826 PF05696.6 EFE41851.1 - 0.052 13.6 1.0 0.12 12.4 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF826) PTE PF02126.13 EFE41851.1 - 0.078 11.9 0.1 0.32 9.9 0.0 2.0 2 0 0 2 2 2 0 Phosphotriesterase family BMFP PF04380.8 EFE41851.1 - 2.1 8.5 9.8 0.62 10.2 0.3 4.0 3 1 2 5 5 5 0 Membrane fusogenic activity DUF2664 PF10867.3 EFE41851.1 - 2.2 8.9 9.9 0.12 13.0 1.3 2.7 2 2 1 3 3 3 0 Protein of unknown function (DUF2664) Apc4_WD40 PF12894.2 EFE41852.1 - 0.0057 16.1 0.2 0.013 14.9 0.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Mre11_DNA_bind PF04152.9 EFE41853.1 - 8.1e-58 195.1 0.3 1.5e-57 194.2 0.2 1.5 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 EFE41853.1 - 5e-21 75.0 0.5 8.2e-21 74.3 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.1 EFE41853.1 - 0.068 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily MPLKIP PF15502.1 EFE41853.1 - 4.8 7.8 10.0 1.5 9.4 0.0 3.3 3 0 0 3 3 3 0 M-phase-specific PLK1-interacting protein GDPD PF03009.12 EFE41854.1 - 0.061 12.8 0.1 0.24 10.8 0.0 1.9 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family GST_C PF00043.20 EFE41855.1 - 1.4e-15 57.0 0.0 2.8e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFE41855.1 - 1.2e-11 44.6 0.0 2.2e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFE41855.1 - 1.2e-10 41.4 0.0 2.9e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE41855.1 - 3.5e-10 39.6 0.0 6.8e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EFE41855.1 - 3e-09 36.7 0.0 5.8e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 EFE41855.1 - 0.00039 20.8 0.0 0.00056 20.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Aldedh PF00171.17 EFE41856.1 - 2.7e-186 619.4 0.1 3.2e-186 619.1 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Metallophos PF00149.23 EFE41857.1 - 6.2e-27 94.3 0.0 9.3e-27 93.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 2OG-FeII_Oxy PF03171.15 EFE41858.1 - 3.3e-10 40.1 0.0 3.2e-09 36.9 0.0 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EFE41858.1 - 5.9e-09 36.4 0.0 1.2e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ctr PF04145.10 EFE41859.1 - 1.4e-27 96.4 0.1 2e-27 96.0 0.1 1.2 1 0 0 1 1 1 1 Ctr copper transporter family DUF1673 PF07895.6 EFE41859.1 - 0.053 13.0 0.2 0.078 12.5 0.0 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) DUF204 PF02659.10 EFE41859.1 - 8.3 6.6 8.7 20 5.3 4.1 2.7 2 1 0 2 2 2 0 Domain of unknown function DUF Smg4_UPF3 PF03467.10 EFE41860.1 - 4.2e-23 82.2 0.0 1.5e-22 80.4 0.0 2.0 1 0 0 1 1 1 1 Smg-4/UPF3 family RRM_1 PF00076.17 EFE41860.1 - 6.8e-09 35.2 0.0 8.5e-08 31.7 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41860.1 - 6.6e-07 29.2 0.0 2.8e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41860.1 - 2.2e-06 27.4 0.0 5.9e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CrtC PF07143.6 EFE41861.1 - 0.0083 15.4 0.2 0.013 14.8 0.2 1.5 1 0 0 1 1 1 1 Hydroxyneurosporene synthase (CrtC) zf-C2H2 PF00096.21 EFE41862.1 - 2.5e-09 36.9 11.4 0.00022 21.3 3.2 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFE41862.1 - 4.9e-07 29.7 13.6 1.4e-06 28.3 1.6 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFE41862.1 - 0.00032 20.8 12.5 0.054 13.8 0.1 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EFE41862.1 - 0.00077 19.2 4.4 0.34 10.8 0.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE41862.1 - 0.0022 18.1 4.1 0.76 10.0 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFE41862.1 - 0.0037 17.4 5.2 0.28 11.4 0.8 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type SprT-like PF10263.4 EFE41862.1 - 0.014 15.0 0.2 0.021 14.5 0.2 1.3 1 0 0 1 1 1 0 SprT-like family zf-BED PF02892.10 EFE41862.1 - 0.02 14.6 1.5 0.96 9.2 0.0 2.5 2 0 0 2 2 2 0 BED zinc finger zf-H2C2_5 PF13909.1 EFE41862.1 - 0.056 13.7 2.6 0.056 13.7 1.8 3.7 4 0 0 4 4 4 0 C2H2-type zinc-finger domain Prok-RING_1 PF14446.1 EFE41862.1 - 0.41 10.4 4.3 4.9 6.9 0.5 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 p450 PF00067.17 EFE41863.1 - 2.1e-62 211.1 0.0 2.8e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DivIC PF04977.10 EFE41864.1 - 0.045 13.2 0.1 0.17 11.4 0.1 2.0 1 0 0 1 1 1 0 Septum formation initiator GATA PF00320.22 EFE41865.1 - 1.1e-15 56.6 1.1 2.4e-15 55.5 0.8 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.5 EFE41865.1 - 7.7e-14 50.9 2.7 1.4e-13 50.1 1.9 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TF_Zn_Ribbon PF08271.7 EFE41865.1 - 0.19 11.0 0.2 0.41 9.9 0.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Aldedh PF00171.17 EFE41866.1 - 4.6e-103 345.0 0.1 5.4e-103 344.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OCD_Mu_crystall PF02423.10 EFE41867.1 - 2e-12 46.5 0.1 1.4e-10 40.4 0.1 2.8 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.15 EFE41867.1 - 0.001 19.1 0.0 0.0075 16.3 0.0 2.2 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase USP8_interact PF08941.5 EFE41868.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 USP8 interacting Fungal_trans PF04082.13 EFE41868.1 - 0.51 9.1 2.8 2.9 6.6 0.1 2.6 3 0 0 3 3 3 0 Fungal specific transcription factor domain Amino_oxidase PF01593.19 EFE41869.1 - 6.7e-26 91.3 0.1 1.5e-25 90.2 0.1 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase LEA_6 PF10714.4 EFE41870.1 - 1.7 8.4 6.8 0.63 9.8 1.0 2.8 3 0 0 3 3 3 0 Late embryogenesis abundant protein 18 Metallophos_2 PF12850.2 EFE41871.1 - 1.1e-06 28.5 0.3 4.4e-06 26.6 0.2 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2183 PF09949.4 EFE41872.1 - 5.1e-32 109.7 0.0 1.4e-31 108.3 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) CarboxypepD_reg PF13620.1 EFE41872.1 - 0.0098 15.9 0.1 0.12 12.4 0.0 2.5 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain RPAP1_N PF08621.5 EFE41872.1 - 0.074 12.6 1.3 0.17 11.4 0.9 1.5 1 0 0 1 1 1 0 RPAP1-like, N-terminal GTPase_Cys_C PF12631.2 EFE41872.1 - 0.27 11.6 1.2 2.4 8.6 0.3 2.6 2 0 0 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE PI31_Prot_N PF11566.3 EFE41873.1 - 2.4e-22 79.2 0.0 3.2e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.6 EFE41873.1 - 3.6e-17 62.7 14.5 3.6e-17 62.7 10.0 2.9 3 0 0 3 3 3 1 PI31 proteasome regulator Metallophos PF00149.23 EFE41874.1 - 1.8e-44 151.5 0.8 2.1e-44 151.2 0.6 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase adh_short_C2 PF13561.1 EFE41875.1 - 7.6e-30 104.4 0.1 8.8e-30 104.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFE41875.1 - 3.7e-29 101.7 0.2 4.7e-29 101.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE41875.1 - 1.3e-10 41.2 0.1 1.9e-10 40.6 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFE41875.1 - 0.00071 19.6 0.6 0.0046 16.9 0.3 2.0 2 0 0 2 2 2 1 NADH(P)-binding THF_DHG_CYH_C PF02882.14 EFE41875.1 - 0.01 14.9 0.2 0.015 14.3 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pyr_redox PF00070.22 EFE41875.1 - 0.012 15.9 0.2 0.031 14.6 0.2 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 EFE41875.1 - 0.017 14.2 0.0 0.029 13.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1776 PF08643.5 EFE41875.1 - 0.019 14.0 0.0 0.027 13.5 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Shikimate_DH PF01488.15 EFE41875.1 - 0.029 14.4 0.2 0.051 13.6 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF3112 PF11309.3 EFE41876.1 - 2.7e-45 154.0 16.5 1.8e-42 144.8 3.3 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3112) Phage_Gp23 PF10669.4 EFE41876.1 - 1.1 9.3 2.9 0.62 10.1 0.2 1.8 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) TPR_11 PF13414.1 EFE41877.1 - 1.9e-14 53.0 0.8 1.2e-12 47.2 0.1 2.3 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 EFE41877.1 - 7e-08 31.7 0.2 0.00029 20.3 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFE41877.1 - 8.4e-06 25.3 0.3 0.029 14.2 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE41877.1 - 1.2e-05 25.1 0.3 2.9e-05 23.9 0.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE41877.1 - 7.2e-05 22.2 0.1 0.087 12.6 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 EFE41877.1 - 0.0028 17.7 0.5 0.0055 16.8 0.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 EFE41877.1 - 0.011 16.3 0.2 1.2 9.9 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFE41877.1 - 0.057 13.7 0.2 0.23 11.8 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 EFE41878.1 - 4.7e-27 94.7 0.0 5.7e-26 91.2 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41878.1 - 2.1e-12 46.6 0.0 2.1e-08 33.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PTR2 PF00854.16 EFE41880.1 - 1.3e-48 165.6 15.5 2.1e-47 161.7 10.7 2.2 1 1 0 1 1 1 1 POT family Glyco_hydro_18 PF00704.23 EFE41881.1 - 8.4e-85 285.2 2.4 1.4e-84 284.4 1.7 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 ubiquitin PF00240.18 EFE41882.1 - 1.7e-34 117.0 1.1 2.8e-34 116.3 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.14 EFE41882.1 - 7.5e-28 96.1 1.9 1.6e-27 95.0 1.3 1.6 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.3 EFE41882.1 - 7.9e-20 70.3 0.8 1.4e-19 69.5 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 EFE41882.1 - 9.6e-06 25.7 0.2 4.3e-05 23.6 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 EFE41882.1 - 0.00016 21.4 0.0 0.00026 20.7 0.0 1.3 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 EFE41882.1 - 0.00077 19.3 0.5 0.0017 18.2 0.3 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 EFE41882.1 - 0.0035 17.4 0.5 0.0048 17.0 0.4 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.16 EFE41882.1 - 0.0091 15.8 0.5 0.015 15.1 0.4 1.3 1 0 0 1 1 1 1 IBR domain DUF2207 PF09972.4 EFE41882.1 - 0.038 12.5 0.3 0.041 12.4 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2870 PF11069.3 EFE41882.1 - 0.064 13.2 0.2 0.17 11.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) Plexin_cytopl PF08337.7 EFE41882.1 - 0.13 10.5 2.3 2.3 6.4 0.1 2.0 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain zf-H2C2_2 PF13465.1 EFE41883.1 - 2.1e-10 40.3 10.3 3.5e-05 23.8 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 EFE41883.1 - 2.9e-07 30.4 17.9 0.00082 19.5 3.1 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE41883.1 - 4.4e-05 23.5 13.1 0.031 14.5 1.7 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EFE41883.1 - 0.009 15.8 7.7 0.24 11.3 1.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-BED PF02892.10 EFE41883.1 - 0.19 11.5 7.3 0.17 11.6 3.5 2.1 1 1 1 2 2 2 0 BED zinc finger DUF155 PF02582.9 EFE41884.1 - 5.7e-44 150.0 0.0 8.7e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Clathrin PF00637.15 EFE41885.1 - 1.6e-18 66.6 0.0 6.7e-18 64.6 0.0 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS WD40 PF00400.27 EFE41885.1 - 2.9e-07 30.1 2.0 0.04 13.8 0.4 3.9 3 1 0 3 3 3 2 WD domain, G-beta repeat Vps39_1 PF10366.4 EFE41885.1 - 0.14 12.1 0.2 0.48 10.4 0.0 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Coatomer_WDAD PF04053.9 EFE41885.1 - 0.56 8.9 0.1 4.8 5.8 0.0 2.0 2 0 0 2 2 2 0 Coatomer WD associated region RXT2_N PF08595.6 EFE41885.1 - 5.9 6.6 6.8 0.83 9.4 0.9 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal Nop14 PF04147.7 EFE41885.1 - 7.4 4.3 5.1 14 3.4 3.5 1.3 1 0 0 1 1 1 0 Nop14-like family DDOST_48kD PF03345.9 EFE41888.1 - 1.3e-162 541.1 0.0 1.5e-162 540.9 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Abhydro_lipase PF04083.11 EFE41890.1 - 2.5e-24 84.3 0.5 4.6e-24 83.5 0.1 1.7 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.15 EFE41890.1 - 1.2e-19 70.7 0.3 1.9e-19 70.1 0.2 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFE41890.1 - 1.2e-06 28.6 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE41890.1 - 1.7e-05 24.5 0.0 8.5e-05 22.3 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 EFE41890.1 - 0.00018 21.0 0.0 0.21 10.9 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 EFE41890.1 - 0.062 12.7 0.1 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pyr_redox PF00070.22 EFE41891.1 - 2.6e-15 56.5 0.0 2.4e-11 43.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE41891.1 - 4.6e-14 52.7 0.0 3.1e-13 50.0 0.0 3.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE41891.1 - 1.7e-07 31.4 0.0 7.3e-05 22.9 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE41891.1 - 5.6e-07 28.7 0.0 0.00016 20.7 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 EFE41891.1 - 6.8e-05 21.6 0.0 0.13 10.8 0.0 2.9 3 0 0 3 3 3 2 Tryptophan halogenase DAO PF01266.19 EFE41891.1 - 0.0026 16.7 0.1 1.2 7.9 0.0 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFE41891.1 - 0.012 14.5 0.0 1 8.2 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.1 EFE41891.1 - 0.017 14.9 0.0 32 4.2 0.0 3.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding TrkA_N PF02254.13 EFE41891.1 - 0.024 14.6 0.0 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain Metallophos PF00149.23 EFE41892.1 - 4.3e-09 36.0 4.4 3.2e-08 33.2 2.8 2.3 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE41892.1 - 3.8e-08 33.3 0.1 7.3e-08 32.3 0.1 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MutL PF13941.1 EFE41892.1 - 0.034 12.4 0.0 0.049 11.9 0.0 1.1 1 0 0 1 1 1 0 MutL protein Metallophos_3 PF14582.1 EFE41892.1 - 0.065 12.3 0.0 4.4 6.3 0.0 2.2 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Ribosomal_L13 PF00572.13 EFE41893.1 - 1.8e-10 40.9 0.0 2e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Ribosomal_L13 PF00572.13 EFE41894.1 - 0.0002 21.3 0.3 0.00046 20.2 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L13 AMP-binding PF00501.23 EFE41895.1 - 4.5e-62 209.7 0.0 1.4e-32 112.5 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.1 EFE41895.1 - 6.1e-14 52.7 0.0 1.2e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LysR_substrate PF03466.15 EFE41895.1 - 0.018 14.1 0.0 0.038 13.0 0.0 1.4 1 0 0 1 1 1 0 LysR substrate binding domain LRR_4 PF12799.2 EFE41896.1 - 2.1e-11 43.1 5.9 0.078 12.6 0.0 7.2 3 2 4 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE41896.1 - 5.8e-11 41.9 13.0 0.011 15.5 0.0 6.4 4 2 2 6 6 6 4 Leucine rich repeat F-box-like PF12937.2 EFE41896.1 - 4e-10 39.2 1.5 4e-10 39.2 1.0 3.0 3 0 0 3 3 3 1 F-box-like LRR_1 PF00560.28 EFE41896.1 - 1.3e-06 27.5 19.2 3.4 8.0 0.0 10.3 7 4 1 8 8 8 1 Leucine Rich Repeat F-box PF00646.28 EFE41896.1 - 0.002 17.7 9.4 0.0037 16.8 1.3 3.5 3 0 0 3 3 3 1 F-box domain Peptidase_M28 PF04389.12 EFE41897.1 - 1.1e-32 113.2 0.1 1.7e-32 112.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M28 ATP-synt_8 PF00895.15 EFE41897.1 - 0.034 14.3 0.1 0.034 14.3 0.0 5.3 6 2 1 7 7 7 0 ATP synthase protein 8 Peptidase_M20 PF01546.23 EFE41897.1 - 0.092 12.2 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Med10 PF09748.4 EFE41899.1 - 1.2e-36 125.3 0.1 4.7e-30 104.0 0.0 2.1 2 0 0 2 2 2 2 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.2 EFE41899.1 - 0.017 14.7 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) DUF2417 PF10329.4 EFE41900.1 - 0.073 12.4 0.0 0.073 12.4 0.0 2.5 3 1 0 3 3 3 0 Region of unknown function (DUF2417) Metallophos PF00149.23 EFE41901.1 - 7.2e-05 22.2 0.2 0.00012 21.5 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE41901.1 - 0.038 13.8 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Arch_ATPase PF01637.13 EFE41902.1 - 9.2e-05 22.2 0.1 0.00025 20.8 0.0 1.7 2 0 0 2 2 2 1 Archaeal ATPase AAA_16 PF13191.1 EFE41902.1 - 0.00028 20.9 2.1 0.016 15.1 1.5 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.24 EFE41902.1 - 0.00032 20.9 0.0 0.035 14.2 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE41902.1 - 0.013 15.5 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 EFE41902.1 - 0.022 13.6 0.0 0.048 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF2859 PF11072.3 EFE41902.1 - 0.043 13.2 0.0 0.08 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2859) AAA_5 PF07728.9 EFE41902.1 - 0.071 12.8 0.0 0.24 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.20 EFE41902.1 - 0.084 12.3 0.0 1.5 8.2 0.0 2.2 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Miro PF08477.8 EFE41902.1 - 0.094 13.2 0.0 0.44 11.0 0.0 2.3 1 1 0 1 1 1 0 Miro-like protein CLU PF13236.1 EFE41903.1 - 1.7e-79 266.3 0.0 2.7e-79 265.6 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 EFE41903.1 - 9e-55 185.1 0.0 2.5e-54 183.7 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 EFE41903.1 - 8.7e-26 89.8 0.3 3.1e-25 88.1 0.2 2.0 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 EFE41903.1 - 4e-25 87.5 3.2 9.2e-11 41.5 0.0 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 EFE41903.1 - 1.4e-15 56.6 0.0 0.0021 17.9 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 EFE41903.1 - 1.1e-06 28.2 1.6 0.042 13.5 0.0 3.5 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.12 EFE41903.1 - 0.0001 21.9 4.6 0.3 11.1 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE41903.1 - 0.00051 19.6 0.9 0.61 10.0 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE41903.1 - 0.0011 19.6 0.0 0.76 10.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFE41903.1 - 0.029 14.5 1.4 1.3e+02 3.2 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat FHIPEP PF00771.15 EFE41903.1 - 0.15 10.3 0.2 4.1 5.5 0.0 2.2 2 0 0 2 2 2 0 FHIPEP family Ferric_reduct PF01794.14 EFE41905.1 - 2.6e-19 69.5 8.7 2.6e-19 69.5 6.0 2.7 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EFE41905.1 - 2.1e-17 63.4 0.0 6.3e-15 55.4 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFE41905.1 - 5.7e-15 55.0 0.0 2.3e-14 53.1 0.0 2.0 1 1 0 1 1 1 1 FAD-binding domain GST_N_3 PF13417.1 EFE41906.1 - 4.3e-15 55.7 0.0 7.1e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE41906.1 - 1.6e-11 44.0 0.0 3e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE41906.1 - 5.1e-11 42.3 0.0 9.7e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFE41906.1 - 1.5e-10 41.0 0.0 3.3e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE41906.1 - 1e-09 38.2 0.0 1.8e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE41906.1 - 2.2e-08 34.4 0.0 4.8e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain REV PF00424.13 EFE41907.1 - 4.3 7.3 7.5 2.1 8.3 0.8 2.3 1 1 1 2 2 2 0 REV protein (anti-repression trans-activator protein) Tubulin PF00091.20 EFE41908.1 - 7e-55 186.1 0.0 9.1e-55 185.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.1 EFE41908.1 - 0.00088 18.7 0.0 0.0017 17.8 0.0 1.4 1 1 0 1 1 1 1 Tubulin domain Lipase_3 PF01764.20 EFE41908.1 - 0.031 13.8 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) HAMP PF00672.20 EFE41909.1 - 0.37 10.9 0.1 0.37 10.9 0.1 1.8 2 0 0 2 2 2 0 HAMP domain Peptidase_M24 PF00557.19 EFE41910.1 - 3.8e-28 98.4 0.0 6.4e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 EFE41910.1 - 1e-15 58.3 0.1 4.1e-11 43.5 0.1 3.5 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain SOR_SNZ PF01680.12 EFE41912.1 - 1.1e-103 345.2 9.8 6.8e-102 339.4 5.6 2.4 2 1 0 2 2 2 1 SOR/SNZ family ThiG PF05690.9 EFE41912.1 - 1.1e-09 37.7 5.4 1.4e-07 30.8 0.0 2.7 3 1 1 4 4 4 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 EFE41912.1 - 0.00078 18.7 0.1 0.011 15.0 0.0 2.4 2 0 0 2 2 2 1 Histidine biosynthesis protein Dus PF01207.12 EFE41912.1 - 0.0036 16.1 0.0 0.37 9.5 0.0 2.4 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.16 EFE41912.1 - 0.022 13.8 0.0 0.06 12.3 0.0 1.8 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase TMP-TENI PF02581.12 EFE41912.1 - 0.027 13.5 0.3 0.91 8.6 0.0 3.0 3 0 0 3 3 3 0 Thiamine monophosphate synthase/TENI NanE PF04131.9 EFE41912.1 - 0.029 13.3 0.6 0.23 10.4 0.0 2.3 2 1 1 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase OMPdecase PF00215.19 EFE41912.1 - 0.038 13.3 0.1 0.39 10.0 0.0 2.2 1 1 2 3 3 3 0 Orotidine 5'-phosphate decarboxylase / HUMPS family FUN14 PF04930.10 EFE41913.1 - 3.6e-09 36.8 0.6 1.7e-08 34.6 0.4 1.9 1 1 0 1 1 1 1 FUN14 family DUF3487 PF11990.3 EFE41913.1 - 0.067 12.5 0.1 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) ORC2 PF04084.9 EFE41914.1 - 8.3e-94 314.0 0.0 1e-93 313.7 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 AT_hook PF02178.14 EFE41914.1 - 3.4 7.6 9.4 10 6.1 6.5 1.9 1 0 0 1 1 1 0 AT hook motif ArgJ PF01960.13 EFE41915.1 - 1.2e-141 471.6 0.1 1.4e-141 471.4 0.0 1.0 1 0 0 1 1 1 1 ArgJ family SecY PF00344.15 EFE41916.1 - 3.7e-93 312.2 11.2 4.2e-93 312.0 7.8 1.0 1 0 0 1 1 1 1 SecY translocase Phage_GP20 PF06810.6 EFE41918.1 - 0.0074 15.7 20.3 0.0074 15.7 14.1 3.9 3 1 1 4 4 4 1 Phage minor structural protein GP20 NPV_P10 PF05531.7 EFE41918.1 - 1.4 9.2 10.3 2 8.7 1.4 3.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TMCO5 PF14992.1 EFE41918.1 - 4.2 6.4 35.7 1.8 7.6 11.1 2.4 1 1 1 2 2 2 0 TMCO5 family TPR_MLP1_2 PF07926.7 EFE41918.1 - 4.2 7.1 41.5 0.12 12.0 3.4 3.6 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Nup54 PF13874.1 EFE41918.1 - 5.9 6.5 21.8 0.14 11.8 7.8 2.9 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Herpes_UL45 PF05473.7 EFE41919.1 - 0.039 13.3 2.1 0.068 12.5 1.5 1.5 1 0 0 1 1 1 0 UL45 protein MUG113 PF13455.1 EFE41920.1 - 3.8e-27 94.5 1.0 8.5e-27 93.4 0.7 1.6 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.4 EFE41920.1 - 3e-18 66.0 0.2 7.6e-18 64.7 0.1 1.7 1 0 0 1 1 1 1 T5orf172 domain Glyco_transf_54 PF04666.8 EFE41921.1 - 3.9e-15 55.3 0.0 3.9e-11 42.2 0.0 3.1 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region AFOR_N PF02730.10 EFE41922.1 - 0.00099 18.5 0.0 0.0014 18.0 0.0 1.1 1 0 0 1 1 1 1 Aldehyde ferredoxin oxidoreductase, N-terminal domain WD40 PF00400.27 EFE41923.1 - 1.7e-21 75.2 8.7 1.8e-06 27.5 0.2 7.0 6 0 0 6 6 6 4 WD domain, G-beta repeat NACHT PF05729.7 EFE41923.1 - 5.5e-09 35.9 0.7 2.3e-08 33.8 0.1 2.3 2 0 0 2 2 2 1 NACHT domain Peptidase_S8 PF00082.17 EFE41923.1 - 5.3e-08 32.3 0.0 8.4e-08 31.6 0.0 1.3 1 0 0 1 1 1 1 Subtilase family PD40 PF07676.7 EFE41923.1 - 3.5e-05 23.3 2.6 28 4.5 0.0 6.9 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat KAP_NTPase PF07693.9 EFE41923.1 - 0.00018 20.6 0.0 0.00029 19.9 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Lactonase PF10282.4 EFE41923.1 - 0.00037 19.6 0.0 0.00089 18.4 0.0 1.6 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller AAA_16 PF13191.1 EFE41923.1 - 0.00072 19.5 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Nbas_N PF15492.1 EFE41923.1 - 0.0039 16.3 0.3 3.3 6.7 0.0 4.1 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.3 EFE41923.1 - 0.018 13.1 0.0 0.3 9.1 0.0 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 AAA_22 PF13401.1 EFE41923.1 - 0.03 14.4 0.0 0.11 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EFE41923.1 - 0.14 11.5 0.0 0.35 10.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Proteasome_A_N PF10584.4 EFE41923.1 - 1.1 8.7 13.8 3 7.2 0.0 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature tRNA-synt_2c PF01411.14 EFE41924.1 - 1.2e-08 33.7 0.0 1.6e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 EFE41924.1 - 4.9e-06 26.3 0.4 8.3e-06 25.6 0.3 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain NAD_binding_10 PF13460.1 EFE41925.1 - 4.3e-23 82.2 0.0 5.6e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFE41925.1 - 7.1e-05 22.1 0.0 0.0003 20.1 0.0 1.8 2 0 0 2 2 2 1 NmrA-like family FAD_binding_3 PF01494.14 EFE41926.1 - 5.5e-14 51.9 0.1 5.8e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DUF2199 PF09965.4 EFE41926.1 - 0.0026 17.6 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2199) MFS_1 PF07690.11 EFE41929.1 - 2.2e-54 184.4 45.2 3.3e-38 131.3 13.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE41929.1 - 2.8e-06 26.0 9.6 1e-05 24.1 3.1 3.2 1 1 1 2 2 2 1 MFS/sugar transport protein MFS_3 PF05977.8 EFE41929.1 - 0.00091 17.4 1.6 0.00091 17.4 1.1 2.3 2 1 0 2 2 2 1 Transmembrane secretion effector Asp-Al_Ex PF06826.7 EFE41929.1 - 0.029 13.8 17.5 0.013 14.9 5.0 3.1 2 1 1 3 3 3 0 Predicted Permease Membrane Region LacY_symp PF01306.14 EFE41929.1 - 0.083 11.4 5.9 0.38 9.2 0.0 2.5 3 0 0 3 3 3 0 LacY proton/sugar symporter ATG22 PF11700.3 EFE41929.1 - 0.16 10.4 14.3 0.12 10.8 4.0 3.5 3 1 0 3 3 3 0 Vacuole effluxer Atg22 like Herpes_pp38 PF04846.8 EFE41929.1 - 0.85 8.9 4.6 1.5 8.1 0.8 2.8 2 0 0 2 2 2 0 Herpesvirus pp38 phosphoprotein ABC_membrane PF00664.18 EFE41930.1 - 2.7e-90 302.5 38.9 2.4e-46 158.3 8.9 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE41930.1 - 1.1e-68 229.7 0.0 4.9e-33 114.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE41930.1 - 3.6e-15 55.7 0.0 8.7e-05 21.8 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE41930.1 - 4.3e-11 43.3 0.0 0.0038 17.2 0.0 4.6 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.1 EFE41930.1 - 7.2e-09 35.0 0.6 0.0004 19.8 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE41930.1 - 3.7e-08 33.5 1.9 0.00053 20.0 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 EFE41930.1 - 9.3e-08 32.9 0.0 0.03 15.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.4 EFE41930.1 - 2e-07 29.9 2.0 0.017 13.7 0.0 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class DUF258 PF03193.11 EFE41930.1 - 1e-06 28.0 0.1 0.015 14.4 0.0 2.7 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFE41930.1 - 2.4e-06 27.7 1.0 0.13 12.4 0.0 3.9 2 2 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFE41930.1 - 4.1e-06 26.3 2.3 0.055 12.8 0.0 3.7 4 0 0 4 4 4 2 AAA domain AAA_30 PF13604.1 EFE41930.1 - 3.4e-05 23.5 1.1 1.5 8.3 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA PF00004.24 EFE41930.1 - 0.00014 22.0 4.8 0.26 11.5 0.3 4.6 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EFE41930.1 - 0.00018 21.3 0.0 0.86 9.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EFE41930.1 - 0.00021 20.8 1.8 2.5 7.4 0.2 4.4 4 0 0 4 4 4 2 AAA-like domain AAA_5 PF07728.9 EFE41930.1 - 0.00036 20.2 0.2 0.73 9.5 0.0 3.1 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 EFE41930.1 - 0.00094 19.0 2.7 1.3 8.9 0.2 3.6 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.1 EFE41930.1 - 0.0015 18.8 0.0 1.3 9.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE41930.1 - 0.0016 18.1 1.0 2 8.2 0.1 3.1 2 0 0 2 2 2 2 Part of AAA domain SRP54 PF00448.17 EFE41930.1 - 0.0029 17.0 0.1 2 7.7 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_23 PF13476.1 EFE41930.1 - 0.0039 17.5 3.2 2.4 8.4 0.0 3.7 3 1 0 3 3 3 1 AAA domain AAA_14 PF13173.1 EFE41930.1 - 0.004 17.0 0.1 1.7 8.5 0.0 3.6 4 0 0 4 4 4 1 AAA domain MobB PF03205.9 EFE41930.1 - 0.0056 16.3 0.2 5.1 6.8 0.0 2.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.10 EFE41930.1 - 0.0061 15.3 0.1 0.28 9.8 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_28 PF13521.1 EFE41930.1 - 0.012 15.5 0.3 5.9 6.8 0.1 3.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EFE41930.1 - 0.012 14.6 0.1 3.1 6.8 0.0 2.9 3 0 0 3 3 3 0 Zeta toxin RNA_helicase PF00910.17 EFE41930.1 - 0.014 15.5 0.0 4.4 7.5 0.0 3.1 2 0 0 2 2 2 0 RNA helicase Katanin_con80 PF13925.1 EFE41930.1 - 0.14 11.9 0.0 11 5.7 0.0 2.4 2 0 0 2 2 2 0 con80 domain of Katanin DUF87 PF01935.12 EFE41930.1 - 0.22 11.3 3.0 2.8 7.6 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function DUF87 Skp1 PF01466.14 EFE41931.1 - 4.4e-39 132.3 2.2 7e-39 131.7 1.6 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 EFE41931.1 - 8.9e-23 80.1 0.0 1.7e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain CM_2 PF01817.16 EFE41931.1 - 0.062 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Chorismate mutase type II Hex_IIIa PF02455.11 EFE41932.1 - 0.038 12.6 9.5 0.044 12.4 6.6 1.0 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) MIP-T3 PF10243.4 EFE41932.1 - 1 7.7 23.6 1.1 7.6 16.3 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1777 PF08648.7 EFE41932.1 - 1.5 8.5 32.5 1.9 8.1 22.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF1510 PF07423.6 EFE41932.1 - 2.4 7.4 16.6 3.3 7.0 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) eIF-3_zeta PF05091.7 EFE41932.1 - 4.1 5.9 13.7 4.5 5.7 9.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DNA_pol_viral_N PF00242.12 EFE41932.1 - 5.1 6.0 12.1 5.6 5.8 8.4 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Glyco_transf_22 PF03901.12 EFE41933.1 - 3.1e-35 121.9 14.5 3e-33 115.4 10.1 2.2 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family Fungal_trans PF04082.13 EFE41934.1 - 1.3e-13 50.4 0.8 3.7e-13 48.9 0.5 1.9 1 0 0 1 1 1 1 Fungal specific transcription factor domain Nucleo_P87 PF07267.6 EFE41934.1 - 4.1 5.9 6.6 19 3.7 5.3 1.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Suf PF05843.9 EFE41934.1 - 4.5 6.9 8.5 7.8 6.1 5.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RINGv PF12906.2 EFE41935.1 - 1.6e-09 37.6 2.6 1e-08 35.1 0.5 2.3 2 0 0 2 2 2 1 RING-variant domain zf-RING_2 PF13639.1 EFE41935.1 - 0.0044 16.8 3.3 0.022 14.5 0.5 2.2 2 0 0 2 2 2 1 Ring finger domain Herpes_gE PF02480.11 EFE41935.1 - 0.033 12.4 0.0 0.046 11.9 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4611 PF15387.1 EFE41935.1 - 0.15 12.2 2.5 0.26 11.4 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) PHD PF00628.24 EFE41935.1 - 0.97 9.1 5.6 0.34 10.6 1.7 1.8 2 0 0 2 2 2 0 PHD-finger Proteasome PF00227.21 EFE41936.1 - 1.5e-57 193.9 0.0 6.2e-33 113.6 0.0 2.0 1 1 1 2 2 2 2 Proteasome subunit Methyltransf_2 PF00891.13 EFE41936.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Ribonuclease_3 PF00636.21 EFE41937.1 - 4.4e-43 146.3 0.0 1.8e-20 73.5 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain DEAD PF00270.24 EFE41937.1 - 1e-20 73.9 0.0 2.1e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ribonucleas_3_3 PF14622.1 EFE41937.1 - 1.2e-19 70.4 0.1 2.2e-11 43.8 0.0 3.7 2 1 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.9 EFE41937.1 - 7.4e-19 67.3 0.1 1.6e-18 66.2 0.0 1.6 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.26 EFE41937.1 - 4.7e-14 52.0 0.0 1.4e-13 50.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE41937.1 - 1.9e-11 44.1 0.0 3.7e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit dsrm PF00035.20 EFE41937.1 - 0.0018 18.8 0.3 0.01 16.4 0.0 2.3 2 0 0 2 2 2 1 Double-stranded RNA binding motif zf-C2H2_jaz PF12171.3 EFE41938.1 - 0.011 15.8 0.3 0.14 12.2 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.9 EFE41938.1 - 0.035 13.7 0.4 0.083 12.5 0.3 1.6 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2 PF00096.21 EFE41938.1 - 0.58 10.6 4.2 2.3 8.7 0.0 3.6 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-LYAR PF08790.6 EFE41938.1 - 0.82 9.4 3.1 3.7 7.3 0.1 2.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-H2C2_2 PF13465.1 EFE41938.1 - 0.85 10.0 6.0 1 9.7 0.2 3.2 3 0 0 3 3 3 0 Zinc-finger double domain 6PGD PF00393.14 EFE41939.1 - 2.4e-53 181.2 0.0 3.9e-53 180.5 0.0 1.3 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 EFE41939.1 - 1.3e-31 109.6 0.1 2.3e-31 108.8 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 EFE41939.1 - 6.8e-07 29.1 0.1 1.3e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 EFE41939.1 - 2e-05 24.3 0.0 3.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 EFE41939.1 - 0.0016 18.8 0.0 0.0044 17.4 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.9 EFE41939.1 - 0.0047 16.3 0.2 0.011 15.1 0.1 1.7 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.15 EFE41939.1 - 0.0054 16.8 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.11 EFE41939.1 - 0.014 14.8 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.14 EFE41939.1 - 0.059 12.5 1.3 0.064 12.3 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.19 EFE41939.1 - 0.064 12.1 0.2 0.11 11.3 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE41939.1 - 0.07 13.1 0.1 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFE41939.1 - 0.18 12.2 1.1 0.56 10.6 0.3 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RTA1 PF04479.8 EFE41940.1 - 1.3e-44 152.3 1.1 1.7e-44 151.9 0.8 1.1 1 0 0 1 1 1 1 RTA1 like protein DUF3098 PF11297.3 EFE41940.1 - 0.82 9.4 3.9 3.7 7.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) DUF805 PF05656.9 EFE41940.1 - 4.3 7.1 12.0 2.5 7.9 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF805) DUF3040 PF11239.3 EFE41940.1 - 9 6.4 8.0 13 5.8 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) LSM PF01423.17 EFE41942.1 - 1.4e-12 46.9 1.1 1.5e-12 46.8 0.1 1.5 2 0 0 2 2 2 1 LSM domain DUF334 PF03904.8 EFE41942.1 - 0.12 11.7 0.1 0.28 10.4 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF334) NUC173 PF08161.7 EFE41943.1 - 1.6e-75 252.8 0.1 7.2e-74 247.4 0.0 2.6 2 0 0 2 2 2 1 NUC173 domain HEAT_2 PF13646.1 EFE41943.1 - 1.9 8.8 8.6 5 7.4 0.4 5.0 5 1 0 5 5 5 0 HEAT repeats Band_3_cyto PF07565.8 EFE41944.1 - 0.022 14.2 1.0 0.52 9.7 0.3 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain XRN_N PF03159.13 EFE41944.1 - 0.14 11.5 2.4 0.36 10.1 1.4 1.8 1 1 1 2 2 2 0 XRN 5'-3' exonuclease N-terminus PAP1 PF08601.5 EFE41944.1 - 0.96 9.0 20.9 0.028 14.1 6.3 2.2 2 0 0 2 2 2 0 Transcription factor PAP1 DDHD PF02862.12 EFE41944.1 - 0.97 9.1 11.7 0.13 11.9 3.1 2.2 2 0 0 2 2 2 0 DDHD domain NPR3 PF03666.8 EFE41944.1 - 2 6.8 11.5 0.1 11.1 1.2 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 TFIIA PF03153.8 EFE41944.1 - 6 6.6 18.5 3.9 7.2 5.5 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.17 EFE41945.1 - 8.8e-10 38.0 0.0 1.9e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41945.1 - 1.7e-07 31.0 0.0 3.6e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41945.1 - 0.077 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RF-1 PF00472.15 EFE41946.1 - 0.035 13.9 3.5 0.15 11.8 2.4 2.0 1 1 0 1 1 1 0 RF-1 domain SURF1 PF02104.10 EFE41946.1 - 0.068 12.9 0.3 0.084 12.6 0.2 1.1 1 0 0 1 1 1 0 SURF1 family Glyco_trans_1_2 PF13524.1 EFE41946.1 - 0.15 12.3 0.6 0.27 11.5 0.3 1.5 1 1 0 1 1 1 0 Glycosyl transferases group 1 U3_assoc_6 PF08640.6 EFE41947.1 - 4.6e-29 100.0 1.3 9.4e-29 99.0 0.4 1.9 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.1 EFE41947.1 - 0.0033 17.9 4.5 0.27 11.9 0.3 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat NRDE-2 PF08424.5 EFE41947.1 - 0.032 13.1 0.1 0.047 12.5 0.1 1.4 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference Frag1 PF10277.4 EFE41948.1 - 9.7e-42 142.8 7.0 9.7e-42 142.8 4.9 2.5 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family HemX PF04375.9 EFE41949.1 - 0.0089 14.6 0.0 0.011 14.3 0.0 1.0 1 0 0 1 1 1 1 HemX DUF1664 PF07889.7 EFE41949.1 - 0.019 14.7 0.6 0.2 11.4 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Apolipoprotein PF01442.13 EFE41949.1 - 0.051 13.0 0.1 0.067 12.6 0.1 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Cytochrom_B562 PF07361.6 EFE41949.1 - 0.062 13.7 1.0 0.13 12.6 0.1 1.8 1 1 1 2 2 2 0 Cytochrome b562 DUF883 PF05957.8 EFE41949.1 - 1.1 9.6 5.0 1.2 9.6 1.2 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) CPSF100_C PF13299.1 EFE41951.1 - 9.6e-42 142.8 0.1 9.6e-42 142.8 0.1 2.0 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 EFE41951.1 - 6.4e-29 100.4 0.0 1.8e-28 98.9 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_2 PF12706.2 EFE41951.1 - 0.00057 19.4 0.0 0.026 14.0 0.0 2.4 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.7 EFE41951.1 - 0.0016 18.2 0.0 0.0046 16.7 0.0 1.8 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B PF00753.22 EFE41951.1 - 0.084 12.5 0.1 0.41 10.2 0.0 2.0 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily tRNA-synt_2 PF00152.15 EFE41953.1 - 6.2e-58 196.1 0.0 9.8e-58 195.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFE41953.1 - 2.2e-07 30.6 0.0 5.4e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Gti1_Pac2 PF09729.4 EFE41954.1 - 2.1e-50 170.9 1.3 4e-49 166.7 0.9 2.3 1 1 0 1 1 1 1 Gti1/Pac2 family DUF2434 PF10361.4 EFE41955.1 - 1.2e-122 408.7 5.5 1.4e-122 408.4 3.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) DUF2700 PF10912.3 EFE41955.1 - 0.053 13.5 0.3 0.84 9.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2700) Flg_new PF09479.5 EFE41957.1 - 0.017 15.1 0.2 0.025 14.6 0.1 1.2 1 0 0 1 1 1 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) Annexin PF00191.15 EFE41959.1 - 1.6e-62 207.2 0.1 9.3e-18 63.8 0.0 4.2 4 0 0 4 4 4 4 Annexin EBP PF05241.7 EFE41960.1 - 4.3e-63 211.8 3.6 5.3e-63 211.5 2.5 1.0 1 0 0 1 1 1 1 Emopamil binding protein NOA36 PF06524.7 EFE41961.1 - 0.027 13.7 7.0 0.34 10.1 0.3 2.5 2 0 0 2 2 2 0 NOA36 protein zf-C3HC4 PF00097.20 EFE41962.1 - 5.3e-08 32.3 5.3 5.3e-08 32.3 3.7 4.6 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE41962.1 - 1e-05 25.4 6.3 1e-05 25.4 4.3 4.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 EFE41962.1 - 2.1e-05 24.2 0.6 2.1e-05 24.2 0.4 2.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein SH3_9 PF14604.1 EFE41962.1 - 0.0001 21.8 2.8 0.00011 21.7 0.1 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 EFE41962.1 - 0.17 11.2 0.2 0.41 10.0 0.1 1.7 1 0 0 1 1 1 0 SH3 domain FHA PF00498.21 EFE41964.1 - 5e-16 58.5 0.0 9.6e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain MscS_porin PF12795.2 EFE41964.1 - 0.0049 16.2 3.3 0.0049 16.2 2.3 2.8 3 0 0 3 3 3 1 Mechanosensitive ion channel porin domain ERM PF00769.14 EFE41964.1 - 0.1 12.0 21.5 0.43 10.0 6.4 2.6 2 0 0 2 2 2 0 Ezrin/radixin/moesin family CENP-Q PF13094.1 EFE41964.1 - 0.15 12.0 19.2 0.26 11.3 3.8 2.9 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Fungal_trans_2 PF11951.3 EFE41965.1 - 1.6e-68 231.0 0.2 2.2e-68 230.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE41965.1 - 1.2e-09 37.8 10.0 2.2e-09 37.0 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.14 EFE41965.1 - 1.7 8.5 9.9 6.2 6.8 6.9 2.0 1 0 0 1 1 1 0 AT hook motif ABC_tran PF00005.22 EFE41966.1 - 5.2e-50 169.3 0.1 3.7e-25 88.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.19 EFE41966.1 - 1.2e-47 161.8 34.0 5.9e-26 90.9 9.6 2.3 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.1 EFE41966.1 - 3.5e-16 60.0 4.4 6.7e-08 32.8 1.0 4.5 3 1 0 3 3 3 2 AAA domain AAA_15 PF13175.1 EFE41966.1 - 9.3e-11 41.4 0.1 0.1 11.6 0.0 4.1 4 0 0 4 4 4 3 AAA ATPase domain AAA_23 PF13476.1 EFE41966.1 - 3.7e-10 40.4 0.3 1.5e-05 25.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 EFE41966.1 - 2.6e-08 33.3 0.5 0.015 14.5 0.1 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EFE41966.1 - 1.1e-07 31.2 2.0 0.0093 15.1 0.7 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 EFE41966.1 - 1.5e-06 27.7 1.1 0.061 12.7 0.0 3.3 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.1 EFE41966.1 - 1.8e-06 28.1 0.2 0.045 13.7 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_19 PF13245.1 EFE41966.1 - 3.4e-06 26.7 0.3 0.088 12.5 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain AAA_17 PF13207.1 EFE41966.1 - 3.7e-06 27.7 0.0 0.063 14.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFE41966.1 - 6.1e-06 26.4 0.4 0.094 12.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 EFE41966.1 - 1.6e-05 24.3 4.5 0.085 12.3 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain NACHT PF05729.7 EFE41966.1 - 2.8e-05 23.8 1.1 0.022 14.3 0.0 2.4 2 0 0 2 2 2 2 NACHT domain Arch_ATPase PF01637.13 EFE41966.1 - 3.4e-05 23.6 0.2 0.0044 16.7 0.0 2.3 2 0 0 2 2 2 1 Archaeal ATPase AAA_28 PF13521.1 EFE41966.1 - 0.00013 21.9 0.2 0.16 11.9 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 EFE41966.1 - 0.00022 21.4 0.4 1.2 9.3 0.1 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) cobW PF02492.14 EFE41966.1 - 0.00079 18.9 1.8 0.13 11.6 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 EFE41966.1 - 0.0015 18.0 4.0 0.41 10.0 0.5 2.3 2 0 0 2 2 2 2 AAA-like domain MobB PF03205.9 EFE41966.1 - 0.0015 18.2 0.9 0.62 9.7 0.0 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 EFE41966.1 - 0.0017 18.4 0.2 1 9.5 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Miro PF08477.8 EFE41966.1 - 0.0027 18.2 0.6 1.4 9.4 0.1 2.7 2 0 0 2 2 2 1 Miro-like protein AAA_18 PF13238.1 EFE41966.1 - 0.0031 17.8 0.4 2.6 8.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 EFE41966.1 - 0.005 16.7 0.2 4.2 7.3 0.0 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit T2SE PF00437.15 EFE41966.1 - 0.0051 15.7 0.1 0.78 8.5 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_5 PF07728.9 EFE41966.1 - 0.0069 16.1 0.3 4.7 6.9 0.0 3.8 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 EFE41966.1 - 0.012 15.1 0.2 5.1 6.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 EFE41966.1 - 0.014 15.2 0.1 1 9.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EFE41966.1 - 0.02 14.0 1.2 4.9 6.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin UPF0079 PF02367.12 EFE41966.1 - 0.027 14.1 0.8 4.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 NTPase_1 PF03266.10 EFE41966.1 - 0.03 14.0 0.8 5.9 6.5 0.2 2.8 3 0 0 3 3 3 0 NTPase Pox_A32 PF04665.7 EFE41966.1 - 0.031 13.5 1.4 4.3 6.5 0.2 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_24 PF13479.1 EFE41966.1 - 0.033 13.7 0.5 2.1 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 EFE41966.1 - 0.046 13.2 0.0 5.1 6.5 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain RuvB_N PF05496.7 EFE41966.1 - 0.052 12.5 0.3 3.1 6.7 0.1 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus MMR_HSR1 PF01926.18 EFE41966.1 - 0.062 13.2 1.6 0.95 9.4 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase IstB_IS21 PF01695.12 EFE41966.1 - 0.11 11.9 0.9 0.8 9.1 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.13 EFE41966.1 - 0.14 11.6 0.7 3.8 6.9 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family PduV-EutP PF10662.4 EFE41966.1 - 0.15 11.5 0.8 16 4.9 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PRK PF00485.13 EFE41966.1 - 0.21 11.1 0.6 11 5.5 0.1 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF2075 PF09848.4 EFE41966.1 - 0.22 10.4 0.3 11 4.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Bys1 PF04681.7 EFE41967.1 - 1.3e-05 24.9 0.2 1.6e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Thaumatin PF00314.12 EFE41967.1 - 1.9e-05 24.2 0.9 0.073 12.5 0.3 2.3 1 1 1 2 2 2 2 Thaumatin family Dicty_spore_N PF04562.7 EFE41967.1 - 0.05 13.8 1.5 0.082 13.1 1.0 1.5 1 1 0 1 1 1 0 Dictyostelium spore coat protein, N terminus Sec23_trunk PF04811.10 EFE41968.1 - 1.4e-48 165.3 0.0 9.2e-48 162.7 0.0 2.0 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 EFE41968.1 - 6.5e-18 65.0 0.0 1.7e-17 63.6 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EFE41968.1 - 9.9e-17 60.2 5.5 2.1e-16 59.1 3.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.10 EFE41968.1 - 3.1e-15 55.4 0.3 5.4e-14 51.4 0.2 2.5 1 1 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.17 EFE41968.1 - 7.4e-07 28.7 0.0 1.4e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Fe-ADH PF00465.14 EFE41968.1 - 0.18 10.4 0.1 0.36 9.4 0.1 1.4 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase DUF3954 PF13128.1 EFE41968.1 - 1.5 8.2 3.2 16 5.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3954) AA_permease_2 PF13520.1 EFE41969.1 - 8.5e-32 110.2 16.7 9.4e-32 110.0 11.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE41969.1 - 4.5e-12 45.0 14.1 5.2e-12 44.8 9.7 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4064 PF13273.1 EFE41969.1 - 0.0076 16.3 7.8 0.71 10.0 0.1 3.1 2 2 1 3 3 3 2 Protein of unknown function (DUF4064) DUF202 PF02656.10 EFE41969.1 - 1.7 8.9 6.4 0.78 9.9 0.1 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF202) RRM_1 PF00076.17 EFE41970.1 - 3.8e-14 52.0 0.0 6.9e-14 51.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE41970.1 - 5.8e-11 42.2 0.0 1.1e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE41970.1 - 4.7e-05 23.1 0.0 0.00013 21.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MOZ_SAS PF01853.13 EFE41971.1 - 7.7e-56 188.3 0.2 2.5e-52 176.8 0.1 2.1 2 0 0 2 2 2 2 MOZ/SAS family Cpn60_TCP1 PF00118.19 EFE41972.1 - 8.6e-130 433.5 0.4 9.7e-130 433.4 0.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nop PF01798.13 EFE41973.1 - 1.1e-59 200.0 0.0 2e-59 199.1 0.0 1.5 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EFE41973.1 - 1.2e-25 88.9 0.2 3e-25 87.7 0.2 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 EFE41973.1 - 7e-14 51.7 0.1 7e-14 51.7 0.1 4.0 4 1 0 4 4 4 1 NOP5NT (NUC127) domain GAGA_bind PF06217.7 EFE41973.1 - 2.5 8.0 14.4 4.1 7.2 10.0 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family DUF3767 PF12597.3 EFE41975.1 - 1.2e-35 121.6 0.1 2.7e-35 120.5 0.0 1.6 1 1 1 2 2 2 2 Protein of unknown function (DUF3767) DUF1744 PF08490.7 EFE41976.1 - 2.6e-142 474.1 0.3 3.6e-142 473.6 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.14 EFE41976.1 - 2.1e-65 220.7 0.4 2.1e-65 220.7 0.3 2.5 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 EFE41976.1 - 1e-23 83.9 0.0 1.5e-22 80.0 0.0 2.4 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 EFE41976.1 - 3.5e-10 39.7 0.1 1e-09 38.2 0.1 1.8 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 EFE41976.1 - 1.6e-05 24.7 0.0 7.7e-05 22.5 0.0 2.2 1 0 0 1 1 1 1 RNase_H superfamily Pkinase PF00069.20 EFE41977.1 - 2.8e-63 213.4 0.1 5.4e-62 209.2 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE41977.1 - 1.4e-23 83.3 0.0 5.1e-23 81.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE41977.1 - 2.5e-07 29.9 0.0 4.7e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE41977.1 - 0.00031 20.5 0.1 0.00047 19.9 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE41977.1 - 0.0011 18.1 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 EFE41977.1 - 0.055 12.7 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL AMMECR1 PF01871.12 EFE41978.1 - 5.6e-33 113.4 0.0 2.6e-32 111.2 0.0 2.0 1 1 0 1 1 1 1 AMMECR1 SGT1 PF07093.6 EFE41979.1 - 7.2e-138 460.5 23.9 6.1e-136 454.2 16.6 2.0 1 1 0 1 1 1 1 SGT1 protein eIF-1a PF01176.14 EFE41979.1 - 0.16 11.4 0.2 0.88 9.0 0.0 2.4 4 0 0 4 4 4 0 Translation initiation factor 1A / IF-1 Microtub_assoc PF07989.6 EFE41980.1 - 3.7e-22 77.9 2.3 3.7e-22 77.9 1.6 10.9 7 2 4 12 12 12 2 Microtubule associated PACT_coil_coil PF10495.4 EFE41980.1 - 1.9e-09 37.2 1.2 6.9e-09 35.5 0.9 2.1 1 0 0 1 1 1 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein TMF_DNA_bd PF12329.3 EFE41980.1 - 6.9e-08 32.1 14.1 6.9e-08 32.1 9.8 15.4 8 5 5 14 14 14 2 TATA element modulatory factor 1 DNA binding AAA PF00004.24 EFE41981.1 - 3.8e-43 146.8 0.0 6.1e-43 146.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 EFE41981.1 - 8e-26 89.7 0.1 3.7e-25 87.5 0.1 2.2 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 EFE41981.1 - 1.5e-22 79.2 2.0 3.2e-22 78.1 0.9 1.9 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 EFE41981.1 - 2.5e-06 28.2 0.0 6.8e-05 23.6 0.0 2.8 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.7 EFE41981.1 - 1.7e-05 23.9 0.0 3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EFE41981.1 - 2e-05 24.4 0.0 5.7e-05 23.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_2 PF07724.9 EFE41981.1 - 2.9e-05 24.0 0.0 0.00035 20.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 EFE41981.1 - 3.2e-05 23.4 0.0 6.5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.1 EFE41981.1 - 3.5e-05 23.9 0.2 0.0021 18.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFE41981.1 - 5.8e-05 22.8 0.0 0.00033 20.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFE41981.1 - 0.00017 21.6 0.0 0.0012 18.9 0.0 2.2 2 1 0 2 2 1 1 AAA ATPase domain TIP49 PF06068.8 EFE41981.1 - 0.00019 20.2 0.0 0.00028 19.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_25 PF13481.1 EFE41981.1 - 0.00024 20.5 0.3 0.2 11.0 0.1 3.2 3 1 1 4 4 3 1 AAA domain AAA_33 PF13671.1 EFE41981.1 - 0.00044 20.1 0.0 0.00087 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EFE41981.1 - 0.00062 18.7 0.0 0.0055 15.6 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.1 EFE41981.1 - 0.0025 17.4 0.0 0.016 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFE41981.1 - 0.0026 18.0 0.0 0.018 15.3 0.0 2.4 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.17 EFE41981.1 - 0.003 17.7 0.0 0.0095 16.0 0.0 1.9 2 0 0 2 2 1 1 RNA helicase Arch_ATPase PF01637.13 EFE41981.1 - 0.012 15.3 0.1 0.17 11.5 0.0 2.4 2 1 1 3 3 3 0 Archaeal ATPase KaiC PF06745.8 EFE41981.1 - 0.014 14.4 0.0 7.3 5.6 0.0 2.9 2 1 1 3 3 3 0 KaiC NACHT PF05729.7 EFE41981.1 - 0.018 14.7 0.0 0.32 10.6 0.0 2.2 1 1 1 2 2 2 0 NACHT domain ResIII PF04851.10 EFE41981.1 - 0.021 14.6 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EFE41981.1 - 0.025 14.3 0.0 0.063 13.0 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Mg_chelatase PF01078.16 EFE41981.1 - 0.031 13.4 0.0 0.062 12.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 EFE41981.1 - 0.037 13.1 0.1 0.18 10.8 0.0 2.0 1 1 1 2 2 2 0 Zeta toxin Peptidase_M28 PF04389.12 EFE41981.1 - 0.037 13.7 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Peptidase family M28 PhoH PF02562.11 EFE41981.1 - 0.044 13.0 0.0 0.093 11.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.12 EFE41981.1 - 0.065 12.0 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Torsin PF06309.6 EFE41981.1 - 0.081 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Torsin USP8_dimer PF08969.6 EFE41981.1 - 0.11 12.4 0.7 0.22 11.4 0.5 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain Sigma54_activ_2 PF14532.1 EFE41981.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.21 EFE41981.1 - 0.12 11.7 0.0 0.38 10.2 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain TPR_1 PF00515.23 EFE41981.1 - 0.13 11.9 0.6 0.52 10.0 0.4 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_28 PF13521.1 EFE41981.1 - 0.15 12.0 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Guanylate_kin PF00625.16 EFE41981.1 - 0.16 11.3 0.0 0.4 10.0 0.0 1.6 1 0 0 1 1 1 0 Guanylate kinase Prefoldin_2 PF01920.15 EFE41982.1 - 1.9e-18 66.1 17.5 2.6e-17 62.5 12.1 2.1 1 1 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.6 EFE41982.1 - 0.00028 20.5 9.1 0.001 18.7 2.4 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Prefoldin_3 PF13758.1 EFE41982.1 - 0.0052 16.5 6.0 0.012 15.3 3.6 1.8 1 1 1 2 2 2 1 Prefoldin subunit HDV_ag PF01517.13 EFE41982.1 - 0.024 14.3 0.5 0.029 14.0 0.4 1.1 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen CMAS PF02353.15 EFE41982.1 - 0.067 12.2 0.1 0.085 11.9 0.1 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Prefoldin PF02996.12 EFE41982.1 - 0.075 12.6 11.4 0.19 11.3 0.1 2.5 2 1 0 2 2 2 0 Prefoldin subunit DUF972 PF06156.8 EFE41982.1 - 0.14 12.5 6.7 0.65 10.3 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF1732 PF08340.6 EFE41982.1 - 0.23 11.2 3.9 1.5 8.6 2.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1732) Myosin_tail_1 PF01576.14 EFE41982.1 - 0.25 8.9 13.6 0.2 9.3 4.0 2.0 2 0 0 2 2 2 0 Myosin tail Scaffolding_pro PF11418.3 EFE41982.1 - 0.39 11.0 5.2 1.7 8.9 1.1 2.5 1 1 1 2 2 2 0 Phi29 scaffolding protein DUF4164 PF13747.1 EFE41982.1 - 0.46 10.6 7.7 0.36 11.0 2.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) TPR_MLP1_2 PF07926.7 EFE41982.1 - 0.46 10.2 14.1 0.47 10.1 4.8 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein BLOC1_2 PF10046.4 EFE41982.1 - 0.52 10.4 6.9 0.77 9.9 1.7 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.2 EFE41982.1 - 0.65 9.8 18.9 0.36 10.6 5.8 2.2 2 1 0 2 2 2 0 Tropomyosin like Kinetocho_Slk19 PF12709.2 EFE41982.1 - 0.65 10.1 14.3 1.7 8.7 0.4 3.2 2 1 1 3 3 3 0 Central kinetochore-associated Lzipper-MIP1 PF14389.1 EFE41982.1 - 0.89 9.6 13.6 0.082 13.0 2.9 2.4 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF4463 PF14703.1 EFE41982.1 - 0.94 10.0 5.0 1.5 9.3 3.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4463) Taxilin PF09728.4 EFE41982.1 - 1.5 7.8 13.3 9.7 5.1 9.3 2.0 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Mnd1 PF03962.10 EFE41982.1 - 1.8 8.2 15.9 0.41 10.2 4.8 2.0 1 1 1 2 2 2 0 Mnd1 family NPV_P10 PF05531.7 EFE41982.1 - 1.8 8.8 9.2 1.5 9.1 2.4 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.10 EFE41982.1 - 2 7.9 21.5 0.67 9.4 2.1 3.2 2 1 1 3 3 3 0 Septum formation initiator T2SM PF04612.7 EFE41982.1 - 2.1 8.1 6.2 0.47 10.2 1.4 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Ded_cyto PF06920.8 EFE41982.1 - 2.2 7.5 7.2 5.2 6.3 1.8 2.1 2 0 0 2 2 2 0 Dedicator of cytokinesis TMPIT PF07851.8 EFE41982.1 - 3.1 6.7 7.7 0.63 9.0 2.6 1.6 1 1 1 2 2 2 0 TMPIT-like protein IncA PF04156.9 EFE41982.1 - 3.2 7.2 20.9 1.4e+02 1.9 14.5 2.1 1 1 0 1 1 1 0 IncA protein COG2 PF06148.6 EFE41982.1 - 3.7 7.4 6.7 1.3 8.8 1.5 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 U1snRNP70_N PF12220.3 EFE41982.1 - 3.9 7.8 10.8 12 6.3 2.6 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal FemAB PF02388.11 EFE41982.1 - 7.1 5.2 13.5 0.4 9.3 4.3 1.9 1 1 0 2 2 2 0 FemAB family Occludin_ELL PF07303.8 EFE41982.1 - 7.9 7.2 8.3 2 9.1 2.8 2.0 1 1 1 2 2 2 0 Occludin homology domain DUF4140 PF13600.1 EFE41982.1 - 9.4 6.7 11.3 3.9 7.9 2.9 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Metalloenzyme PF01676.13 EFE41983.1 - 6.2e-72 241.9 0.1 7.1e-72 241.8 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.8 EFE41983.1 - 3e-70 236.0 0.0 4e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.17 EFE41983.1 - 1.8e-06 27.5 0.0 4.3e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFE41983.1 - 0.00025 20.3 0.0 0.01 15.0 0.0 2.5 2 1 1 3 3 3 1 Sulfatase Alk_phosphatase PF00245.15 EFE41983.1 - 0.006 15.3 0.0 0.038 12.7 0.0 1.9 2 0 0 2 2 2 1 Alkaline phosphatase Med9 PF07544.8 EFE41984.1 - 2.7e-22 78.3 0.0 5.3e-22 77.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.3 EFE41984.1 - 2 8.4 5.4 2.2 8.2 0.1 2.2 2 0 0 2 2 2 0 Subunit 21 of Mediator complex SHMT PF00464.14 EFE41985.1 - 7.3e-203 673.3 0.0 9.3e-203 672.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.16 EFE41985.1 - 3.1e-06 26.3 0.0 1e-05 24.6 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFE41985.1 - 3.9e-05 22.5 0.0 5.7e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V IL3 PF02059.10 EFE41985.1 - 0.017 15.1 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 Interleukin-3 Beta_elim_lyase PF01212.16 EFE41985.1 - 0.018 14.1 0.0 0.042 12.9 0.0 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase AHH PF14412.1 EFE41985.1 - 0.071 13.1 0.5 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH RNA_polI_A34 PF08208.6 EFE41986.1 - 7.6e-33 113.8 2.0 7.6e-33 113.8 1.4 3.3 2 1 1 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.9 EFE41986.1 - 2.3 6.1 33.5 0.012 13.7 2.4 2.1 2 0 0 2 2 2 0 CDC45-like protein Clp1 PF06807.9 EFE41987.1 - 0.00033 20.4 0.0 0.022 14.5 0.0 2.5 2 0 0 2 2 2 1 Pre-mRNA cleavage complex II protein Clp1 DUF3095 PF11294.3 EFE41987.1 - 0.0095 15.0 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3095) AAA_33 PF13671.1 EFE41987.1 - 0.017 15.0 0.2 0.75 9.6 0.0 3.0 3 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 EFE41987.1 - 0.046 13.1 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_10 PF12846.2 EFE41987.1 - 0.047 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.1 EFE41987.1 - 0.089 12.7 0.7 3.4 7.6 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain DUF4640 PF15480.1 EFE41990.1 - 0.0015 18.1 4.6 0.0018 17.9 3.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4640) FLO_LFY PF01698.11 EFE41990.1 - 1.4 7.6 11.1 1.8 7.3 7.7 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein MDFI PF15316.1 EFE41990.1 - 1.8 8.5 6.3 7.7 6.4 4.4 1.8 1 1 0 1 1 1 0 MyoD family inhibitor DUF2956 PF11169.3 EFE41990.1 - 3.3 7.6 9.4 0.082 12.8 1.3 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2956) Presenilin PF01080.12 EFE41990.1 - 6.2 5.5 6.1 7.9 5.1 4.3 1.1 1 0 0 1 1 1 0 Presenilin GAGA_bind PF06217.7 EFE41990.1 - 9.8 6.0 12.1 12 5.7 8.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Hex_IIIa PF02455.11 EFE41990.1 - 10 4.7 10.6 13 4.3 7.3 1.0 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Folliculin PF11704.3 EFE41991.1 - 4.1e-45 153.3 0.0 8.9e-45 152.2 0.0 1.6 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport PCI_Csn8 PF10075.4 EFE41992.1 - 8.1e-44 148.8 0.0 1.1e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 EFE41992.1 - 3.1e-18 66.0 0.0 3.9e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PDCD2_C PF04194.8 EFE41993.1 - 3.9e-50 169.6 0.6 1e-49 168.2 0.0 1.8 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain CENP-B_dimeris PF09026.5 EFE41994.1 - 0.44 10.7 7.2 0.97 9.7 5.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.8 EFE41994.1 - 0.46 8.2 8.1 0.61 7.7 5.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Prenylcys_lyase PF07156.9 EFE41996.1 - 1.1e-43 149.6 0.0 7.8e-43 146.7 0.0 2.1 1 1 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.1 EFE41996.1 - 1.6e-10 40.8 0.0 3.9e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EFE41996.1 - 5.5e-10 38.9 0.0 1.1e-08 34.6 0.0 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 EFE41996.1 - 0.058 12.2 0.0 0.85 8.4 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Flo11 PF10182.4 EFE41996.1 - 0.12 11.9 0.1 0.27 10.7 0.0 1.6 2 0 0 2 2 2 0 Flo11 domain Glyco_transf_28 PF03033.15 EFE41997.1 - 5.9e-26 90.8 0.0 1.2e-25 89.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 EFE41997.1 - 0.0041 15.7 0.0 0.0061 15.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Vma12 PF11712.3 EFE41998.1 - 1.1e-35 122.4 0.0 1.7e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase ATP_synt_I PF03899.10 EFE41998.1 - 0.15 12.2 0.8 0.29 11.3 0.1 1.7 2 0 0 2 2 2 0 ATP synthase I chain Amidohydro_1 PF01979.15 EFE41999.1 - 8.9e-21 74.8 0.0 3e-20 73.1 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 EFE41999.1 - 4.5e-16 59.6 0.0 1.8e-15 57.6 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 EFE41999.1 - 2.9e-09 36.6 0.0 6.9e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EFE41999.1 - 5.5e-05 22.5 0.0 0.16 11.1 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Glyco_hydro_26 PF02156.10 EFE41999.1 - 0.027 13.9 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 UDP-g_GGTase PF06427.6 EFE42000.1 - 1.2e-68 230.6 0.0 2.8e-68 229.3 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 EFE42000.1 - 0.0002 20.7 0.0 0.00047 19.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 PhzC-PhzF PF02567.11 EFE42003.1 - 0.00032 20.0 0.4 0.0035 16.6 0.3 2.1 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein CrtC PF07143.6 EFE42005.1 - 0.15 11.3 0.0 0.72 9.0 0.0 1.8 2 0 0 2 2 2 0 Hydroxyneurosporene synthase (CrtC) Rpp20 PF12328.3 EFE42006.1 - 1.2e-45 154.6 9.8 4.7e-45 152.7 6.8 1.8 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 EFE42006.1 - 5e-18 64.4 1.0 5e-18 64.4 0.7 1.7 2 0 0 2 2 2 1 Alba TPT PF03151.11 EFE42008.1 - 8.9e-06 25.4 6.0 8.9e-06 25.4 4.2 2.0 1 1 1 2 2 2 1 Triose-phosphate Transporter family SBP_bac_1 PF01547.20 EFE42008.1 - 0.0026 17.5 0.1 2 8.0 0.0 2.1 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein UAA PF08449.6 EFE42008.1 - 0.012 14.5 7.5 0.027 13.4 0.9 2.1 1 1 0 2 2 2 0 UAA transporter family EamA PF00892.15 EFE42008.1 - 0.032 14.2 18.7 0.034 14.1 3.7 2.3 2 1 0 2 2 2 0 EamA-like transporter family ABC_membrane PF00664.18 EFE42008.1 - 3.1 7.1 11.2 10 5.4 0.3 2.5 2 0 0 2 2 2 0 ABC transporter transmembrane region HSP70 PF00012.15 EFE42009.1 - 1.2e-84 284.4 2.6 4.1e-84 282.6 0.4 2.0 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 EFE42009.1 - 8.2e-12 44.3 0.7 1.3e-11 43.7 0.5 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Nucleoplasmin PF03066.10 EFE42009.1 - 0.0025 17.3 2.0 0.0057 16.1 1.4 1.6 1 0 0 1 1 1 1 Nucleoplasmin CENP-B_dimeris PF09026.5 EFE42009.1 - 0.0094 16.1 3.2 0.021 15.0 2.2 1.6 1 0 0 1 1 1 1 Centromere protein B dimerisation domain FAM176 PF14851.1 EFE42009.1 - 0.066 12.8 1.8 0.15 11.7 1.3 1.6 1 0 0 1 1 1 0 FAM176 family Sigma70_ner PF04546.8 EFE42009.1 - 0.37 10.3 7.3 0.18 11.3 3.0 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region PBP1_TM PF14812.1 EFE42009.1 - 0.75 10.1 7.0 1.5 9.1 4.8 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rogdi_lz PF10259.4 EFE42010.1 - 2.7e-74 249.7 0.0 3e-74 249.5 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Mito_fiss_reg PF05308.6 EFE42010.1 - 0.0091 15.3 0.0 0.023 14.0 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial fission regulator BNR_2 PF13088.1 EFE42011.1 - 2.6e-34 118.7 0.2 3.2e-34 118.4 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 EFE42011.1 - 1.6e-10 40.5 0.0 2.2e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 EFE42011.1 - 5 7.3 12.2 4.2 7.6 2.7 4.0 3 0 0 3 3 3 0 BNR/Asp-box repeat Rsm22 PF09243.5 EFE42012.1 - 4.1e-29 101.4 0.0 2.6e-28 98.8 0.0 2.1 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 INTS2 PF14750.1 EFE42012.1 - 0.011 13.3 0.0 0.015 12.8 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 2 DASH_Spc19 PF08287.6 EFE42013.1 - 1.6e-49 167.4 3.0 2.2e-49 167.0 2.1 1.2 1 0 0 1 1 1 1 Spc19 IFP_35_N PF07334.8 EFE42013.1 - 1 9.3 3.4 6.6 6.7 1.5 2.4 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Arb2 PF09757.4 EFE42014.1 - 8.3e-32 110.0 0.0 1.3e-31 109.3 0.0 1.3 1 0 0 1 1 1 1 Arb2 domain Hpr_kinase_N PF02603.11 EFE42014.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase N terminus LRR_8 PF13855.1 EFE42015.1 - 9.5e-09 34.8 1.2 2.8e-08 33.3 0.4 2.2 2 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 EFE42015.1 - 1.5e-07 30.8 0.6 1.5e-07 30.8 0.4 2.6 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EFE42015.1 - 1e-05 24.8 2.1 0.39 10.9 0.2 4.2 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_7 PF13504.1 EFE42015.1 - 0.031 14.4 2.9 17 6.1 0.2 3.8 4 0 0 4 4 4 0 Leucine rich repeat LysM PF01476.15 EFE42017.1 - 2.5e-10 40.0 0.0 1e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 LysM domain DUF3425 PF11905.3 EFE42018.1 - 2e-35 121.6 3.2 3.5e-35 120.8 2.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) BMFP PF04380.8 EFE42018.1 - 0.047 13.8 2.6 0.12 12.5 1.8 1.7 1 0 0 1 1 1 0 Membrane fusogenic activity bZIP_1 PF00170.16 EFE42018.1 - 0.14 12.1 11.8 0.62 10.0 8.2 2.0 1 1 0 1 1 1 0 bZIP transcription factor Actin PF00022.14 EFE42019.1 - 3.9e-88 295.5 0.0 3.8e-83 279.1 0.0 2.0 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.8 EFE42019.1 - 0.089 11.3 0.0 0.32 9.5 0.0 1.8 1 1 0 1 1 1 0 MreB/Mbl protein EamA PF00892.15 EFE42020.1 - 1.7e-05 24.8 1.5 1.7e-05 24.8 1.1 3.9 3 1 0 4 4 4 2 EamA-like transporter family EmrE PF13536.1 EFE42020.1 - 0.00047 20.3 0.9 0.00047 20.3 0.7 3.0 3 1 0 3 3 3 2 Multidrug resistance efflux transporter PgaD PF13994.1 EFE42020.1 - 0.003 17.0 0.0 0.003 17.0 0.0 2.9 3 1 0 3 3 3 1 PgaD-like protein TPT PF03151.11 EFE42020.1 - 6.2 6.4 23.0 0.68 9.5 5.5 3.4 3 2 0 3 3 3 0 Triose-phosphate Transporter family Tubulin PF00091.20 EFE42021.1 - 4.9e-55 186.6 1.2 6.4e-54 183.0 0.8 2.3 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Aldo_ket_red PF00248.16 EFE42021.1 - 2.3e-53 180.8 0.0 3.2e-53 180.4 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Asp_Glu_race PF01177.17 EFE42021.1 - 5.5e-11 42.7 0.0 4.1e-10 39.9 0.0 2.4 2 0 0 2 2 2 1 Asp/Glu/Hydantoin racemase Misat_Tub_SegII PF10644.4 EFE42021.1 - 0.00065 19.7 0.1 0.0014 18.6 0.1 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Plasmodium_Vir PF05795.6 EFE42021.1 - 0.21 10.7 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Tubulin_C PF03953.12 EFE42022.1 - 4.7e-44 149.4 0.1 5.9e-44 149.1 0.1 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain HisG PF01634.13 EFE42022.1 - 0.019 14.5 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 ATP phosphoribosyltransferase CASP_C PF08172.7 EFE42022.1 - 0.046 12.7 0.1 0.057 12.4 0.0 1.3 1 1 0 1 1 1 0 CASP C terminal DUF4163 PF13739.1 EFE42023.1 - 0.093 13.5 1.6 0.11 13.3 1.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4163) Aa_trans PF01490.13 EFE42024.1 - 8.4e-33 113.4 31.9 1.2e-32 112.8 22.1 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CAAD PF14159.1 EFE42024.1 - 0.00078 19.0 2.3 0.00078 19.0 1.6 3.1 4 0 0 4 4 4 1 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase AstB PF04996.7 EFE42025.1 - 0.0014 17.5 0.6 0.0019 17.0 0.4 1.1 1 0 0 1 1 1 1 Succinylarginine dihydrolase Ipi1_N PF12333.3 EFE42026.1 - 5.7e-28 96.8 0.0 5.7e-28 96.8 0.0 2.0 2 1 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation F-box PF00646.28 EFE42027.1 - 0.00015 21.3 0.2 0.0016 18.0 0.0 2.4 2 0 0 2 2 2 1 F-box domain Pyrid_oxidase_2 PF13883.1 EFE42028.1 - 5.2e-36 123.9 0.0 8.2e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.15 EFE42028.1 - 0.014 15.3 0.0 0.084 12.8 0.0 2.0 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Smr PF01713.16 EFE42029.1 - 1.1e-16 60.8 1.6 1.4e-16 60.4 0.3 1.8 2 0 0 2 2 2 1 Smr domain DUF1771 PF08590.5 EFE42029.1 - 0.035 14.1 0.5 0.035 14.1 0.3 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1771) DUF605 PF04652.11 EFE42029.1 - 0.15 11.4 5.7 2.5 7.3 4.0 2.0 2 0 0 2 2 2 0 Vta1 like Spore_YhcN_YlaJ PF09580.5 EFE42029.1 - 0.29 11.2 1.3 0.81 9.7 0.1 1.9 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PAT1 PF09770.4 EFE42029.1 - 0.58 8.3 8.9 0.58 8.3 6.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.1 EFE42029.1 - 5 4.7 7.1 6.7 4.2 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) polyprenyl_synt PF00348.12 EFE42030.1 - 4.6e-51 173.1 0.0 9.5e-51 172.1 0.0 1.5 1 1 0 1 1 1 1 Polyprenyl synthetase DUF4320 PF14208.1 EFE42030.1 - 0.1 12.5 0.1 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) DUF3684 PF12449.3 EFE42030.1 - 0.14 9.7 0.0 0.18 9.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) SQS_PSY PF00494.14 EFE42031.1 - 4.3e-63 213.0 0.2 5.4e-63 212.7 0.1 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase BBIP10 PF14777.1 EFE42031.1 - 0.17 11.2 0.1 0.36 10.2 0.0 1.4 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 RPE65 PF03055.10 EFE42032.1 - 2e-127 425.7 0.0 2.3e-127 425.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Amino_oxidase PF01593.19 EFE42033.1 - 5.6e-17 61.9 0.0 1.9e-16 60.1 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EFE42033.1 - 3.2e-14 52.6 0.1 1.1e-13 50.9 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFE42033.1 - 3.5e-12 45.9 0.0 2.3e-07 30.0 0.0 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFE42033.1 - 4.1e-07 30.0 0.0 2.1e-05 24.5 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE42033.1 - 5.5e-07 28.4 0.2 0.0022 16.5 1.0 2.3 2 0 0 2 2 2 2 HI0933-like protein BTB_2 PF02214.17 EFE42033.1 - 7.1e-06 26.1 0.1 2.2e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 BTB/POZ domain Pyr_redox_3 PF13738.1 EFE42033.1 - 1.1e-05 25.5 0.0 0.00052 20.1 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFE42033.1 - 2e-05 23.6 3.7 6.2e-05 22.0 2.5 1.8 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 EFE42033.1 - 2.4e-05 23.6 2.2 0.00023 20.3 2.5 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 EFE42033.1 - 7.2e-05 21.9 0.3 0.00016 20.8 0.2 1.5 1 0 0 1 1 1 1 Thi4 family BTB PF00651.26 EFE42033.1 - 8.5e-05 22.5 0.0 0.0002 21.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain NAD_binding_9 PF13454.1 EFE42033.1 - 0.0035 17.1 1.2 0.013 15.2 0.1 2.5 4 0 0 4 4 3 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 EFE42033.1 - 0.0041 16.2 0.3 0.0074 15.3 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain GDI PF00996.13 EFE42033.1 - 0.005 15.1 0.1 0.06 11.6 0.0 2.0 2 0 0 2 2 2 1 GDP dissociation inhibitor NAD_binding_7 PF13241.1 EFE42033.1 - 0.014 15.6 0.0 0.04 14.1 0.0 1.8 2 0 0 2 2 1 0 Putative NAD(P)-binding Pyr_redox PF00070.22 EFE42033.1 - 0.046 14.1 5.9 0.2 12.0 1.5 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 EFE42033.1 - 0.13 11.7 0.3 0.24 10.8 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.17 EFE42033.1 - 0.43 9.3 4.7 0.27 10.0 2.0 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EFE42033.1 - 1.7 7.4 6.1 0.25 10.2 0.6 2.1 3 0 0 3 3 3 0 Lycopene cyclase protein MFS_1 PF07690.11 EFE42034.1 - 2.5e-32 111.9 29.2 1.8e-29 102.5 15.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 EFE42034.1 - 0.015 13.3 6.1 0.32 9.0 0.0 2.7 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family F-box PF00646.28 EFE42035.1 - 0.013 15.1 0.1 0.05 13.2 0.0 2.1 1 0 0 1 1 1 0 F-box domain DUF4639 PF15479.1 EFE42035.1 - 0.18 10.4 0.0 0.22 10.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) Spore_GerAC PF05504.6 EFE42035.1 - 0.26 11.0 0.6 0.54 10.0 0.4 1.5 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal EGF_CA PF07645.10 EFE42036.1 - 6.5e-06 26.0 6.0 6.5e-06 26.0 4.1 1.7 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.1 EFE42036.1 - 0.00059 19.9 2.9 0.00059 19.9 2.0 2.4 2 1 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_3 PF12947.2 EFE42036.1 - 0.0023 17.8 4.9 0.0023 17.8 3.4 2.1 2 1 0 2 2 2 1 EGF domain cEGF PF12662.2 EFE42036.1 - 0.003 17.1 0.3 0.003 17.1 0.2 2.2 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF PF00008.22 EFE42036.1 - 0.0043 16.9 5.3 0.021 14.7 3.5 2.2 1 1 0 1 1 1 1 EGF-like domain MCM PF00493.18 EFE42037.1 - 1.2e-135 451.6 0.0 2.2e-135 450.7 0.0 1.4 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EFE42037.1 - 1.8e-26 93.0 0.1 6.7e-26 91.1 0.0 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 EFE42037.1 - 3.5e-07 29.6 0.0 4.8e-05 22.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFE42037.1 - 2.5e-05 24.0 0.0 6.5e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFE42037.1 - 0.003 17.5 1.8 0.9 9.4 0.1 3.5 3 1 0 4 4 4 1 AAA ATPase domain Mg_chelatase_2 PF13335.1 EFE42037.1 - 0.019 15.3 0.1 0.1 12.9 0.0 2.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EFE42037.1 - 0.063 12.8 0.0 0.23 11.0 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 EFE42038.1 - 1.1e-54 184.1 0.0 2.5e-43 147.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 EFE42038.1 - 2.2e-29 101.3 0.1 4.6e-29 100.3 0.1 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 EFE42038.1 - 3.5e-10 40.1 2.1 2.2e-05 24.5 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain NACHT PF05729.7 EFE42038.1 - 4e-07 29.8 0.3 0.00042 20.0 0.0 3.6 3 0 0 3 3 3 1 NACHT domain AAA_2 PF07724.9 EFE42038.1 - 7.4e-07 29.2 0.0 0.035 14.0 0.0 2.7 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 EFE42038.1 - 4.7e-06 26.1 0.1 0.0072 15.7 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.1 EFE42038.1 - 1.8e-05 24.8 0.7 0.64 10.1 0.0 3.9 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.1 EFE42038.1 - 2.3e-05 24.3 0.0 0.22 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.7 EFE42038.1 - 2.7e-05 23.3 0.0 0.014 14.4 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EFE42038.1 - 2.9e-05 24.8 0.0 0.19 12.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EFE42038.1 - 3.6e-05 23.4 0.0 0.064 13.0 0.0 2.9 2 0 0 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 EFE42038.1 - 0.00017 21.9 0.0 0.11 12.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFE42038.1 - 0.0004 19.8 1.8 3.2 7.0 0.0 4.0 2 2 1 4 4 4 1 AAA domain Zeta_toxin PF06414.7 EFE42038.1 - 0.00053 19.1 0.0 0.76 8.8 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_5 PF07728.9 EFE42038.1 - 0.00061 19.5 0.1 1.7 8.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EFE42038.1 - 0.00093 18.0 0.0 0.91 8.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus UPF0079 PF02367.12 EFE42038.1 - 0.0027 17.3 0.3 0.12 12.0 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 EFE42038.1 - 0.0029 17.6 0.0 1.1 9.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE42038.1 - 0.0039 17.0 0.0 0.38 10.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain KAP_NTPase PF07693.9 EFE42038.1 - 0.0047 15.9 0.2 0.098 11.6 0.0 2.5 2 1 1 3 3 2 1 KAP family P-loop domain RNA_helicase PF00910.17 EFE42038.1 - 0.0081 16.3 0.0 6.7 6.9 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Sigma54_activ_2 PF14532.1 EFE42038.1 - 0.012 15.6 0.0 2.7 8.0 0.0 2.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 EFE42038.1 - 0.015 14.4 0.4 0.86 8.7 0.0 2.7 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 EFE42038.1 - 0.022 15.0 0.1 4.7 7.5 0.1 2.7 2 0 0 2 2 2 0 ABC transporter T2SE PF00437.15 EFE42038.1 - 0.027 13.3 0.1 0.1 11.4 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein KaiC PF06745.8 EFE42038.1 - 0.071 12.2 0.1 11 5.0 0.0 2.4 2 0 0 2 2 2 0 KaiC SKI PF01202.17 EFE42038.1 - 0.074 12.9 0.0 5 6.9 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase PhoH PF02562.11 EFE42038.1 - 0.078 12.1 0.1 9.1 5.4 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein Viral_helicase1 PF01443.13 EFE42038.1 - 0.089 12.3 0.0 0.49 9.8 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase APS_kinase PF01583.15 EFE42038.1 - 0.11 12.1 0.1 0.42 10.2 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase cobW PF02492.14 EFE42038.1 - 0.13 11.6 0.4 5.3 6.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activat PF00158.21 EFE42038.1 - 0.16 11.4 0.0 6.6 6.1 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF2075 PF09848.4 EFE42038.1 - 0.18 10.7 0.0 12 4.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.10 EFE42038.1 - 0.22 11.2 0.0 2.7 7.6 0.0 2.2 2 0 0 2 2 2 0 NTPase Arch_ATPase PF01637.13 EFE42038.1 - 0.23 11.1 0.1 31 4.1 0.0 3.1 2 1 1 3 3 3 0 Archaeal ATPase HisG PF01634.13 EFE42039.1 - 2.4e-51 173.5 0.0 3.5e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 EFE42039.1 - 2.2e-27 94.8 0.2 4.3e-27 93.8 0.2 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.6 EFE42039.1 - 0.0096 15.5 0.0 0.053 13.1 0.0 2.0 1 1 0 1 1 1 1 NMT1/THI5 like MutS_V PF00488.16 EFE42040.1 - 1.5e-88 296.1 0.0 2.4e-88 295.4 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFE42040.1 - 1e-36 126.6 0.3 2.1e-36 125.6 0.2 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EFE42040.1 - 3.3e-19 68.9 0.8 4.9e-17 61.9 0.5 2.7 1 1 0 1 1 1 1 MutS domain I MutS_II PF05188.12 EFE42040.1 - 2.6e-10 40.4 0.0 1.5e-09 38.0 0.0 2.4 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.13 EFE42040.1 - 5.8e-08 32.8 0.3 1.4e-07 31.6 0.2 1.7 1 0 0 1 1 1 1 MutS family domain IV LpxB PF02684.10 EFE42040.1 - 0.037 12.6 0.0 0.068 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase zf-C2H2_2 PF12756.2 EFE42041.1 - 0.11 12.6 0.2 0.53 10.4 0.1 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Prenyltrans PF00432.16 EFE42043.1 - 1.4e-38 130.1 5.8 2.5e-12 46.1 0.0 5.8 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EFE42043.1 - 1.7e-17 63.8 0.0 7.6e-11 42.4 0.0 3.7 1 1 1 2 2 2 2 Prenyltransferase-like Prenyltrans_1 PF13243.1 EFE42043.1 - 2.9e-09 36.8 0.0 9.6e-05 22.3 0.0 3.2 1 1 1 3 3 3 2 Prenyltransferase-like RhoGAP PF00620.22 EFE42044.1 - 1.5e-27 96.1 0.0 2.4e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DHC_N1 PF08385.7 EFE42045.1 - 2.1e-182 607.5 7.9 2.1e-182 607.5 5.5 4.1 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 EFE42045.1 - 1.2e-128 429.1 2.6 1.2e-128 429.1 1.8 4.0 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 Dynein_heavy PF03028.10 EFE42045.1 - 1.2e-104 350.7 0.0 4.3e-104 349.0 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_6 PF12774.2 EFE42045.1 - 2e-77 259.8 0.0 5.2e-77 258.4 0.0 1.7 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 EFE42045.1 - 8e-44 149.1 0.1 5.6e-43 146.4 0.1 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_8 PF12780.2 EFE42045.1 - 2e-41 141.7 2.0 1e-40 139.4 0.1 2.6 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.2 EFE42045.1 - 1.9e-39 135.4 7.7 3.5e-39 134.5 5.3 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 EFE42045.1 - 1.6e-32 112.0 0.4 1.4e-10 41.0 0.0 6.1 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_7 PF12775.2 EFE42045.1 - 3e-19 69.1 0.0 1.5e-18 66.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_22 PF13401.1 EFE42045.1 - 3.6e-15 56.2 0.1 0.0093 16.1 0.0 6.4 6 0 0 6 6 4 3 AAA domain AAA PF00004.24 EFE42045.1 - 2.3e-14 53.6 0.0 0.00035 20.7 0.0 4.8 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EFE42045.1 - 2.3e-10 40.5 0.1 0.25 11.2 0.0 5.4 4 0 0 4 4 4 3 AAA domain AAA_17 PF13207.1 EFE42045.1 - 7.3e-09 36.4 0.1 0.042 14.6 0.0 5.7 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.1 EFE42045.1 - 1.5e-08 35.0 0.5 0.05 13.9 0.0 5.3 5 0 0 5 5 4 2 AAA domain AAA_14 PF13173.1 EFE42045.1 - 3.2e-06 27.0 0.0 0.21 11.4 0.0 5.2 5 0 0 5 5 5 1 AAA domain T2SE PF00437.15 EFE42045.1 - 1.1e-05 24.4 0.0 0.077 11.8 0.0 3.2 4 0 0 4 4 4 2 Type II/IV secretion system protein ABC_tran PF00005.22 EFE42045.1 - 2.4e-05 24.6 0.1 2 8.6 0.0 5.0 3 0 0 3 3 3 1 ABC transporter AAA_16 PF13191.1 EFE42045.1 - 2.6e-05 24.2 15.0 0.12 12.3 0.1 8.3 7 1 1 8 8 8 1 AAA ATPase domain Mg_chelatase PF01078.16 EFE42045.1 - 4.1e-05 22.8 1.0 0.5 9.4 0.0 4.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EFE42045.1 - 4.5e-05 23.1 0.3 0.89 9.3 0.0 4.7 4 0 0 4 4 4 1 Part of AAA domain AAA_29 PF13555.1 EFE42045.1 - 0.00013 21.4 0.0 2 7.9 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain IstB_IS21 PF01695.12 EFE42045.1 - 0.002 17.5 0.7 0.32 10.3 0.0 4.1 4 0 0 4 4 4 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 EFE42045.1 - 0.0027 16.8 6.0 0.94 8.5 0.0 4.3 5 0 0 5 5 3 2 Zeta toxin DUF258 PF03193.11 EFE42045.1 - 0.0029 16.7 0.1 7.6 5.6 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 EFE42045.1 - 0.0069 15.8 1.5 0.44 9.9 0.0 4.0 5 0 0 5 5 4 1 AAA domain RNA_helicase PF00910.17 EFE42045.1 - 0.012 15.7 0.1 28 4.9 0.0 4.5 4 0 0 4 4 4 0 RNA helicase PduV-EutP PF10662.4 EFE42045.1 - 0.1 12.0 1.5 7.1 6.1 0.1 4.2 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 EFE42045.1 - 0.2 11.3 0.4 12 5.6 0.0 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B ERM PF00769.14 EFE42045.1 - 8.3 5.8 32.2 2 7.8 0.8 3.0 3 0 0 3 3 2 0 Ezrin/radixin/moesin family Ribonuclease_3 PF00636.21 EFE42046.1 - 2e-40 137.7 0.1 1e-19 71.0 0.0 3.4 4 0 0 4 4 4 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EFE42046.1 - 3.3e-24 85.2 0.0 9.4e-13 48.2 0.0 3.5 2 2 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.9 EFE42046.1 - 1.4e-21 76.0 0.2 1.1e-18 66.7 0.1 3.2 3 0 0 3 3 3 2 Dicer dimerisation domain ResIII PF04851.10 EFE42046.1 - 8.8e-11 41.9 0.2 5.3e-10 39.4 0.1 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EFE42046.1 - 4.2e-09 36.1 0.0 9.9e-09 34.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.20 EFE42046.1 - 0.0064 17.0 0.1 0.76 10.4 0.0 2.8 2 0 0 2 2 2 1 Double-stranded RNA binding motif DUF2075 PF09848.4 EFE42046.1 - 0.05 12.5 0.0 0.092 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TAP42 PF04177.7 EFE42047.1 - 1.5e-107 359.4 3.5 1.8e-107 359.2 2.4 1.0 1 0 0 1 1 1 1 TAP42-like family DUF725 PF05267.7 EFE42047.1 - 0.11 12.3 0.8 0.22 11.4 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF725) PilJ PF13675.1 EFE42047.1 - 5.3 7.4 7.3 3.2 8.0 0.4 2.8 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Lipase_GDSL_2 PF13472.1 EFE42048.1 - 8.2e-06 26.0 0.0 5.1e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFE42048.1 - 0.0023 17.8 0.0 0.0034 17.2 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase PRP21_like_P PF12230.3 EFE42048.1 - 0.093 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein Porphobil_deam PF01379.15 EFE42049.1 - 2.9e-78 261.6 0.0 3.7e-78 261.3 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 EFE42049.1 - 4.8e-18 65.0 0.5 9e-18 64.1 0.3 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Lon_C PF05362.8 EFE42050.1 - 2.6e-68 229.3 0.4 5.5e-68 228.3 0.2 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.24 EFE42050.1 - 3.4e-24 85.5 0.0 2.5e-23 82.7 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) LON PF02190.11 EFE42050.1 - 1.4e-23 83.6 0.2 1.4e-23 83.6 0.1 1.9 2 0 0 2 2 2 1 ATP-dependent protease La (LON) domain ChlI PF13541.1 EFE42050.1 - 4.5e-08 32.6 0.0 1.3e-07 31.2 0.0 1.8 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.9 EFE42050.1 - 6.6e-08 32.3 0.0 2.5e-07 30.4 0.0 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFE42050.1 - 3.8e-06 27.0 0.3 1.9e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.8 EFE42050.1 - 5.8e-06 25.2 0.1 3e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 TIP49 C-terminus IstB_IS21 PF01695.12 EFE42050.1 - 1.2e-05 24.8 0.0 3.2e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.6 EFE42050.1 - 2.2e-05 24.0 0.0 6.6e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE42050.1 - 3e-05 24.8 0.0 0.00012 22.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE42050.1 - 0.00012 21.7 0.1 0.00038 20.1 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 EFE42050.1 - 0.00033 19.7 0.1 0.0013 17.8 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 EFE42050.1 - 0.00043 20.2 0.0 0.0025 17.7 0.0 2.4 1 1 1 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EFE42050.1 - 0.00044 20.3 0.1 0.0046 17.1 0.0 2.7 2 1 1 3 3 2 1 AAA domain Birna_VP4 PF01768.11 EFE42050.1 - 0.00073 18.6 0.0 0.0014 17.7 0.0 1.5 1 0 0 1 1 1 1 Birnavirus VP4 protein AAA_14 PF13173.1 EFE42050.1 - 0.00076 19.3 0.0 0.0034 17.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFE42050.1 - 0.0014 18.5 0.0 0.003 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFE42050.1 - 0.0026 16.8 0.0 0.0053 15.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.1 EFE42050.1 - 0.0039 16.6 0.0 0.0099 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EFE42050.1 - 0.011 15.8 0.0 0.044 13.9 0.0 2.1 1 0 0 1 1 1 0 RNA helicase UPF0079 PF02367.12 EFE42050.1 - 0.014 14.9 0.0 0.043 13.4 0.0 1.8 2 0 0 2 2 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_18 PF13238.1 EFE42050.1 - 0.015 15.6 0.1 0.057 13.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFE42050.1 - 0.018 14.2 0.2 0.046 12.8 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 EFE42050.1 - 0.019 14.3 0.6 0.71 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain NACHT PF05729.7 EFE42050.1 - 0.021 14.4 0.0 0.067 12.8 0.0 1.9 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.1 EFE42050.1 - 0.025 14.1 0.2 0.058 12.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EFE42050.1 - 0.032 13.4 0.0 0.076 12.2 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_23 PF13476.1 EFE42050.1 - 0.035 14.4 0.1 0.035 14.4 0.0 3.0 2 1 1 3 3 1 0 AAA domain AAA_PrkA PF08298.6 EFE42050.1 - 0.036 12.7 0.1 0.28 9.8 0.0 2.0 1 1 0 2 2 2 0 PrkA AAA domain NB-ARC PF00931.17 EFE42050.1 - 0.055 12.3 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain MobB PF03205.9 EFE42050.1 - 0.059 13.0 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activ_2 PF14532.1 EFE42050.1 - 0.069 13.2 0.1 0.37 10.8 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 EFE42050.1 - 0.077 12.6 0.6 0.94 9.1 0.0 3.0 3 1 1 4 4 3 0 Archaeal ATPase AAA_11 PF13086.1 EFE42050.1 - 0.098 12.2 0.0 0.098 12.2 0.0 2.2 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.22 EFE42050.1 - 0.2 11.9 0.1 0.2 11.9 0.1 2.7 1 1 1 2 2 2 0 ABC transporter Ribosomal_L23 PF00276.15 EFE42051.1 - 2e-10 40.4 0.2 3.8e-10 39.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 RIO1 PF01163.17 EFE42052.1 - 4.1e-41 140.4 0.3 2.2e-28 98.8 0.0 2.2 2 0 0 2 2 2 2 RIO1 family APH PF01636.18 EFE42052.1 - 1.5e-06 28.1 0.0 0.0046 16.7 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EFE42052.1 - 2.2e-05 23.6 0.0 0.0006 18.9 0.0 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Rio2_N PF09202.6 EFE42052.1 - 5.3e-05 23.2 1.2 0.00014 21.8 0.9 1.7 1 0 0 1 1 1 1 Rio2, N-terminal Chs3p PF12271.3 EFE42053.1 - 3.6e-138 459.4 15.0 4.3e-138 459.2 10.4 1.1 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit Ribosomal_L18e PF00828.14 EFE42054.1 - 1.5e-17 64.1 0.1 2.7e-17 63.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Pkinase PF00069.20 EFE42055.1 - 9.8e-49 165.8 0.0 1.5e-48 165.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42055.1 - 2.2e-27 95.7 0.0 1.7e-26 92.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Zip PF02535.17 EFE42055.1 - 0.02 13.8 5.1 0.028 13.4 3.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 EFE42055.1 - 0.57 9.5 14.1 0.99 8.7 9.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region BSP_II PF05432.6 EFE42057.1 - 0.047 12.9 12.0 0.048 12.9 8.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Radial_spoke PF04712.7 EFE42057.1 - 0.12 11.1 12.1 0.13 10.9 8.4 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein Myc_N PF01056.13 EFE42057.1 - 0.19 10.8 11.1 0.21 10.7 7.7 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Nucleoplasmin PF03066.10 EFE42057.1 - 0.44 10.0 11.5 0.6 9.6 8.0 1.2 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 EFE42057.1 - 0.52 9.8 13.6 0.62 9.6 9.4 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region PDCD2_C PF04194.8 EFE42057.1 - 1.2 8.6 10.4 1.9 8.0 7.2 1.3 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain AUX_IAA PF02309.11 EFE42057.1 - 1.6 8.4 9.9 1.9 8.1 6.9 1.2 1 0 0 1 1 1 0 AUX/IAA family DUF2890 PF11081.3 EFE42057.1 - 2 8.4 18.0 2.2 8.3 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) alpha-hel2 PF14456.1 EFE42057.1 - 2.1 7.0 7.5 2.5 6.7 5.2 1.0 1 0 0 1 1 1 0 Alpha-helical domain 2 Daxx PF03344.10 EFE42057.1 - 2.8 6.3 20.5 3.4 6.0 14.2 1.1 1 0 0 1 1 1 0 Daxx Family Sporozoite_P67 PF05642.6 EFE42057.1 - 3 5.5 9.2 3.1 5.5 6.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen VID27 PF08553.5 EFE42057.1 - 3.1 5.8 11.9 3.1 5.8 8.3 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein D123 PF07065.9 EFE42057.1 - 3.2 6.7 6.5 4 6.4 4.5 1.1 1 0 0 1 1 1 0 D123 Cytomega_UL84 PF06284.6 EFE42057.1 - 3.2 6.0 7.6 3.1 6.1 5.3 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Pox_RNA_Pol_19 PF05320.7 EFE42057.1 - 5.1 6.8 10.9 6.7 6.4 7.5 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DNA_pol_phi PF04931.8 EFE42057.1 - 7.8 4.1 14.3 7.8 4.1 9.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi TLP-20 PF06088.6 EFE42057.1 - 8.9 5.9 9.3 11 5.6 6.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) SH3_1 PF00018.23 EFE42058.1 - 9.9e-06 24.8 0.0 1.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE42058.1 - 0.0013 18.2 0.0 0.0033 16.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain RCC1_2 PF13540.1 EFE42059.1 - 2.3e-11 43.0 0.8 1.3e-06 27.8 0.1 3.1 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.2 EFE42059.1 - 6.4e-08 32.1 0.1 1.3e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 F-box-like DUF3688 PF12461.3 EFE42059.1 - 0.51 10.7 3.0 0.35 11.2 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3688) PQ-loop PF04193.9 EFE42060.1 - 1.1e-35 120.9 17.3 1e-18 66.5 1.3 2.8 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.11 EFE42060.1 - 0.002 17.9 8.4 0.03 14.1 0.1 2.7 3 0 0 3 3 3 2 Sugar efflux transporter for intercellular exchange Aminotran_1_2 PF00155.16 EFE42062.1 - 2.7e-63 214.1 0.0 3.9e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EFE42062.1 - 0.00024 20.3 0.1 0.00049 19.3 0.0 1.4 2 0 0 2 2 2 1 Beta-eliminating lyase Tmemb_18A PF09771.4 EFE42062.1 - 0.0085 16.0 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 Transmembrane protein 188 AMP-binding PF00501.23 EFE42063.1 - 1.8e-39 135.3 0.0 2.5e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE42063.1 - 0.00037 21.3 0.1 0.00093 20.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M16_C PF05193.16 EFE42064.1 - 6.5e-46 156.3 0.0 4.4e-45 153.6 0.0 2.3 1 1 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFE42064.1 - 6.4e-40 136.3 0.0 5.9e-39 133.1 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Abhydrolase_2 PF02230.11 EFE42065.1 - 2.3e-27 95.8 0.0 2.1e-17 63.3 0.0 2.5 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EFE42065.1 - 9e-08 32.2 0.4 1.7e-07 31.3 0.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE42065.1 - 2.4e-05 24.1 0.0 4.3e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFE42065.1 - 0.0015 17.8 0.0 0.0025 17.0 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 EFE42065.1 - 0.0071 15.9 0.0 0.014 15.0 0.0 1.5 1 1 1 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.8 EFE42065.1 - 0.0074 15.7 0.0 0.019 14.4 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Tom22 PF04281.8 EFE42066.1 - 6.1e-51 171.5 0.2 7.1e-51 171.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF4211 PF13926.1 EFE42067.1 - 6.7e-45 152.2 0.0 1.5e-44 151.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) BUD22 PF09073.5 EFE42067.1 - 0.0013 17.8 7.7 0.0013 17.8 5.3 2.2 3 0 0 3 3 3 1 BUD22 GEMIN8 PF15348.1 EFE42067.1 - 1.7 8.6 7.7 15 5.5 3.7 2.7 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Pox_Ag35 PF03286.9 EFE42067.1 - 2.9 7.3 15.0 0.11 12.0 5.4 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF4449 PF14613.1 EFE42068.1 - 1.5e-66 223.3 0.6 1.5e-66 223.3 0.4 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF4449) Peptidase_M35 PF02102.10 EFE42069.1 - 1.2e-72 244.5 0.0 1.5e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.1 EFE42069.1 - 8.1e-07 29.6 0.0 1.3e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase Ost4 PF10215.4 EFE42070.1 - 0.31 10.5 1.2 0.95 9.0 0.5 2.1 2 0 0 2 2 2 0 Oligosaccaryltransferase vWA-TerF-like PF10138.4 EFE42072.1 - 2.4e-08 34.0 0.0 3.9e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus Pro-rich PF15240.1 EFE42072.1 - 0.00042 20.4 25.0 0.00042 20.4 17.3 3.7 2 1 1 3 3 3 1 Proline-rich VWA_2 PF13519.1 EFE42072.1 - 0.0036 17.4 0.0 0.007 16.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Acetyltransf_1 PF00583.19 EFE42073.1 - 3.7e-05 23.6 0.0 6.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE42073.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.1 EFE42073.1 - 0.062 13.0 0.1 0.14 11.8 0.1 1.7 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Svf1 PF08622.5 EFE42074.1 - 7.9e-126 419.4 0.0 9.8e-126 419.1 0.0 1.1 1 0 0 1 1 1 1 Svf1-like CrtC PF07143.6 EFE42074.1 - 0.015 14.6 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 Hydroxyneurosporene synthase (CrtC) Pkinase PF00069.20 EFE42076.1 - 1.3e-57 194.8 0.0 2.6e-57 193.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42076.1 - 5.9e-21 74.7 0.0 9.2e-21 74.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE42076.1 - 0.0032 16.4 0.0 0.0056 15.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE42076.1 - 0.005 16.5 0.0 0.0099 15.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE42076.1 - 0.12 11.4 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3337 PF11816.3 EFE42077.1 - 3.2e-93 312.7 0.0 2.7e-88 296.5 0.6 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3337) WD40 PF00400.27 EFE42077.1 - 1.8e-27 94.1 19.6 4e-07 29.6 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat Mito_carr PF00153.22 EFE42078.1 - 1.8e-46 155.7 2.0 2e-18 65.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein ATP_bind_3 PF01171.15 EFE42079.1 - 7.5e-26 90.7 0.0 3.5e-24 85.3 0.0 2.4 1 1 0 1 1 1 1 PP-loop family RhoGEF PF00621.15 EFE42080.1 - 1.9e-20 73.5 0.0 3.8e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.3 EFE42080.1 - 3.8e-05 23.2 0.0 7.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DivIVA PF05103.8 EFE42080.1 - 0.62 10.1 4.6 2 8.4 3.2 1.9 1 0 0 1 1 1 0 DivIVA protein Myosin_tail_1 PF01576.14 EFE42080.1 - 1.6 6.3 12.1 0.72 7.4 6.3 1.7 1 1 1 2 2 2 0 Myosin tail Sec7 PF01369.15 EFE42081.1 - 1.3e-57 194.5 0.0 2.2e-57 193.8 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 EFE42081.1 - 6.7e-22 77.7 1.2 1.2e-14 54.0 0.2 3.5 4 0 0 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_12 PF13424.1 EFE42082.1 - 1.8e-11 43.7 0.2 10 6.1 0.0 7.8 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFE42082.1 - 7.5e-11 41.6 12.4 5.2 7.9 0.0 10.1 10 2 2 12 12 11 3 Tetratricopeptide repeat Suf PF05843.9 EFE42082.1 - 6.5e-10 39.1 9.3 0.0076 16.0 0.2 5.6 3 1 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_19 PF14559.1 EFE42082.1 - 1.7e-09 37.8 0.1 0.09 13.1 0.0 6.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.1 EFE42082.1 - 2.1e-07 30.2 4.2 0.00083 18.4 0.5 4.1 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE42082.1 - 8.1e-07 28.5 0.7 7.5 6.2 0.0 7.0 7 1 1 8 8 8 2 TPR repeat TPR_2 PF07719.12 EFE42082.1 - 2.5e-05 23.8 13.0 3.1 7.9 0.0 7.4 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE42082.1 - 4.4e-05 22.9 4.2 0.76 9.7 0.0 5.7 7 0 0 7 7 6 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 EFE42082.1 - 0.00011 21.9 6.3 2.8 7.7 0.1 6.7 6 2 0 7 7 7 1 Mad3/BUB1 homology region 1 TPR_17 PF13431.1 EFE42082.1 - 0.00064 19.7 4.7 1.1 9.5 0.0 6.2 8 0 0 8 8 7 1 Tetratricopeptide repeat HAT PF02184.11 EFE42082.1 - 0.0023 17.6 2.7 1.7 8.4 0.1 5.4 5 0 0 5 5 5 1 HAT (Half-A-TPR) repeat TPR_1 PF00515.23 EFE42082.1 - 0.0058 16.1 0.0 3.5 7.3 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE42082.1 - 0.012 15.3 5.7 93 3.2 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFE42082.1 - 2.9 8.5 9.6 24 5.6 0.0 6.5 8 0 0 8 8 7 0 Tetratricopeptide repeat ATP-synt_D PF01813.12 EFE42083.1 - 3.4e-40 137.7 2.3 3.4e-40 137.7 1.6 2.4 1 1 1 2 2 2 1 ATP synthase subunit D MIS13 PF08202.6 EFE42083.1 - 0.00075 18.6 0.0 0.001 18.1 0.0 1.2 1 0 0 1 1 1 1 Mis12-Mtw1 protein family RRM_1 PF00076.17 EFE42084.1 - 2.2e-25 88.0 3.2 1.1e-11 44.1 0.1 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE42084.1 - 1e-15 57.4 0.1 1.2e-06 28.4 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE42084.1 - 3.8e-15 55.4 0.0 2.8e-07 30.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFCD_C PF12612.3 EFE42085.1 - 3.8e-32 111.2 0.0 1.2e-31 109.6 0.0 1.8 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.17 EFE42085.1 - 0.00011 21.9 0.5 2.6 8.3 0.0 5.3 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 EFE42085.1 - 0.0031 17.9 2.7 1.7 9.2 0.0 4.4 3 0 0 3 3 3 2 HEAT-like repeat Pkinase PF00069.20 EFE42087.1 - 3e-63 213.3 0.0 6.2e-63 212.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42087.1 - 1.7e-35 122.3 0.0 2.8e-35 121.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 EFE42087.1 - 1.8e-33 114.0 13.0 8.2e-19 67.1 3.3 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.17 EFE42087.1 - 4.9e-20 70.9 30.8 1.9e-11 43.4 6.3 2.8 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 EFE42087.1 - 1.5e-06 28.6 0.1 4.7e-06 27.0 0.1 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFE42087.1 - 0.02 13.8 0.0 0.033 13.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like C2 PF00168.25 EFE42087.1 - 0.048 13.5 0.0 0.097 12.5 0.0 1.6 1 0 0 1 1 1 0 C2 domain PHD_2 PF13831.1 EFE42087.1 - 3.9 6.8 15.4 7.5 5.9 2.0 2.7 2 0 0 2 2 2 0 PHD-finger Uds1 PF15456.1 EFE42087.1 - 4 7.4 5.9 0.73 9.8 0.7 2.1 2 0 0 2 2 2 0 Up-regulated During Septation FYVE_2 PF02318.11 EFE42087.1 - 8.1 6.3 19.3 2.5 8.0 3.7 2.6 1 1 1 2 2 2 0 FYVE-type zinc finger eIF-1a PF01176.14 EFE42088.1 - 3e-19 68.1 0.0 3.7e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 ALG3 PF05208.8 EFE42089.1 - 1.2e-113 380.0 20.7 1.4e-113 379.8 14.3 1.0 1 0 0 1 1 1 1 ALG3 protein EpsG PF14897.1 EFE42089.1 - 3.1 6.6 20.6 9.9 4.9 14.3 1.7 1 1 0 1 1 1 0 EpsG family DUF4646 PF15496.1 EFE42090.1 - 2.2e-07 30.9 0.0 3.5e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) PsbM PF05151.7 EFE42091.1 - 0.12 11.9 1.1 0.22 11.1 0.8 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre M protein (PsbM) Metallophos PF00149.23 EFE42092.1 - 7.4e-36 123.4 0.5 7.2e-29 100.6 0.1 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Fungal_trans PF04082.13 EFE42093.1 - 7.6e-40 136.4 0.7 7e-30 103.7 0.1 2.6 2 0 0 2 2 2 2 Fungal specific transcription factor domain V_ATPase_I PF01496.14 EFE42093.1 - 0.63 7.8 0.8 0.96 7.2 0.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lamp PF01299.12 EFE42093.1 - 9 5.3 13.6 16 4.5 9.5 1.3 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) DNA_ligase_A_M PF01068.16 EFE42094.1 - 2.7e-47 160.7 0.0 8.8e-47 159.0 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EFE42094.1 - 3e-35 121.6 0.0 6.4e-35 120.5 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EFE42094.1 - 2.7e-17 62.9 0.0 7.1e-17 61.5 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.21 EFE42094.1 - 1.8e-07 31.2 3.7 0.00074 19.6 0.0 3.3 3 1 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EFE42094.1 - 0.0014 18.4 0.1 0.35 10.7 0.0 2.6 2 0 0 2 2 2 2 twin BRCT domain mRNA_cap_enzyme PF01331.14 EFE42094.1 - 0.015 15.0 0.0 0.3 10.7 0.0 2.9 2 1 0 2 2 2 0 mRNA capping enzyme, catalytic domain RNA_ligase PF09414.5 EFE42094.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA ligase Pkinase PF00069.20 EFE42095.1 - 4.3e-70 235.8 0.0 5.4e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42095.1 - 1.1e-32 113.0 0.0 1.5e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 EFE42095.1 - 3.4e-08 33.8 3.2 1e-07 32.3 2.2 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFE42095.1 - 0.0047 15.9 0.0 0.0074 15.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFE42095.1 - 0.2 10.7 0.1 0.38 9.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_4 PF12763.2 EFE42096.1 - 0.00072 19.2 0.1 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Spb1_C PF07780.7 EFE42098.1 - 8.5e-77 257.4 18.1 8.5e-77 257.4 12.6 3.3 3 1 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.3 EFE42098.1 - 5e-56 188.6 9.2 5e-56 188.6 6.4 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF3381) FtsJ PF01728.14 EFE42098.1 - 2.2e-36 125.5 0.3 3e-31 108.7 0.0 2.7 1 1 1 2 2 2 2 FtsJ-like methyltransferase DUF914 PF06027.7 EFE42099.1 - 4.8e-09 35.5 3.2 8.8e-09 34.6 0.8 1.9 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 EFE42099.1 - 1.5e-08 34.7 19.1 6.1e-08 32.7 3.6 3.0 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.6 EFE42099.1 - 0.00012 21.1 4.2 0.00049 19.1 1.9 2.0 2 0 0 2 2 2 1 UAA transporter family EmrE PF13536.1 EFE42099.1 - 0.00036 20.7 3.7 0.00036 20.7 2.6 2.9 3 2 0 3 3 3 1 Multidrug resistance efflux transporter TPT PF03151.11 EFE42099.1 - 0.12 11.9 19.5 0.042 13.5 3.5 3.0 3 0 0 3 3 3 0 Triose-phosphate Transporter family Ras PF00071.17 EFE42100.1 - 9.4e-55 184.4 0.2 1.2e-54 184.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE42100.1 - 4.4e-19 69.1 0.0 7.1e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE42100.1 - 5.3e-13 48.5 0.0 7.4e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFE42100.1 - 3.5e-07 29.5 0.1 4.6e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EFE42100.1 - 4.5e-07 29.4 0.0 1e-05 25.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EFE42100.1 - 7.7e-07 29.0 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFE42100.1 - 0.00075 18.7 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFE42100.1 - 0.00087 19.4 0.0 0.0014 18.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EFE42100.1 - 0.0089 15.7 0.3 0.019 14.6 0.0 1.6 2 0 0 2 2 2 1 Archaeal ATPase AAA_5 PF07728.9 EFE42100.1 - 0.015 15.0 0.0 0.036 13.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.10 EFE42100.1 - 0.017 14.8 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 NTPase Septin PF00735.13 EFE42100.1 - 0.018 14.0 0.2 0.053 12.5 0.0 1.8 3 0 0 3 3 3 0 Septin AAA_24 PF13479.1 EFE42100.1 - 0.019 14.5 0.1 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.5 EFE42100.1 - 0.019 14.1 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.14 EFE42100.1 - 0.02 14.3 0.0 0.064 12.6 0.0 1.7 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 EFE42100.1 - 0.021 14.8 0.1 0.096 12.6 0.0 2.1 3 0 0 3 3 3 0 AAA ATPase domain AAA_10 PF12846.2 EFE42100.1 - 0.024 14.0 0.2 0.047 13.1 0.1 1.4 1 1 0 1 1 1 0 AAA-like domain PduV-EutP PF10662.4 EFE42100.1 - 0.025 14.0 0.2 0.35 10.3 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 EFE42100.1 - 0.029 14.0 0.0 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ATP_bind_1 PF03029.12 EFE42100.1 - 0.039 13.4 0.2 0.92 9.0 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.12 EFE42100.1 - 0.062 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.7 EFE42100.1 - 0.089 12.4 0.1 0.18 11.4 0.0 1.5 2 0 0 2 2 1 0 NACHT domain ATG16 PF08614.6 EFE42101.1 - 2.7e-39 135.0 16.7 3.1e-39 134.8 11.6 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) CCDC144C PF14915.1 EFE42101.1 - 0.00063 18.7 9.3 0.0011 17.9 6.5 1.3 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region IncA PF04156.9 EFE42101.1 - 0.085 12.4 14.5 0.13 11.7 10.1 1.4 1 1 0 1 1 1 0 IncA protein GvpG PF05120.7 EFE42101.1 - 0.094 12.5 5.4 0.041 13.6 1.4 2.1 1 1 0 1 1 1 0 Gas vesicle protein G Med9 PF07544.8 EFE42101.1 - 0.14 11.8 3.6 0.097 12.4 1.0 1.9 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 KIAA1430 PF13879.1 EFE42101.1 - 0.18 12.2 4.1 0.32 11.4 0.2 2.2 1 1 1 2 2 2 0 KIAA1430 homologue Sec2p PF06428.6 EFE42101.1 - 0.26 11.1 11.4 0.74 9.6 7.9 1.9 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p SecD-TM1 PF13721.1 EFE42101.1 - 0.6 10.3 3.6 0.38 11.0 1.0 1.9 2 1 0 2 2 2 0 SecD export protein N-terminal TM region Nup54 PF13874.1 EFE42101.1 - 1.1 8.9 9.0 1.1 8.8 2.0 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Fez1 PF06818.10 EFE42101.1 - 1.4 8.8 15.0 1.4 8.9 5.1 2.0 1 1 1 2 2 2 0 Fez1 V_ATPase_I PF01496.14 EFE42101.1 - 2.9 5.6 5.0 4.3 5.0 3.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DOT1 PF08123.8 EFE42102.1 - 1.2e-76 256.6 0.0 1.8e-76 256.0 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 EFE42102.1 - 3.4e-06 27.0 0.1 1.2e-05 25.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE42102.1 - 0.00092 18.8 0.0 0.0021 17.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE42102.1 - 0.001 19.6 0.1 0.0022 18.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NmrA PF05368.8 EFE42102.1 - 0.025 13.8 0.0 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family PH PF00169.24 EFE42103.1 - 2e-25 88.9 1.7 6.7e-13 48.7 0.1 2.2 2 0 0 2 2 2 2 PH domain PH_9 PF15410.1 EFE42103.1 - 2.4e-11 43.8 4.6 2e-06 27.9 0.1 3.7 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.1 EFE42103.1 - 9.8e-10 38.6 4.0 0.0012 19.1 0.1 4.0 2 2 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.1 EFE42103.1 - 0.00057 19.9 0.0 0.016 15.2 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain UIM PF02809.15 EFE42103.1 - 0.025 14.1 1.8 0.061 12.9 1.3 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif Glyco_transf_15 PF01793.11 EFE42104.1 - 1.1e-98 330.3 5.4 5.8e-47 160.2 0.0 3.0 3 0 0 3 3 3 3 Glycolipid 2-alpha-mannosyltransferase Abhydrolase_6 PF12697.2 EFE42105.1 - 9.7e-22 77.9 0.1 9.7e-22 77.9 0.1 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE42105.1 - 2.2e-12 47.0 0.0 5.2e-12 45.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE42105.1 - 1.2e-11 44.5 0.0 2.6e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EFE42105.1 - 5.7e-05 22.6 0.0 0.00014 21.3 0.0 1.6 2 0 0 2 2 2 1 Putative esterase DUF915 PF06028.6 EFE42105.1 - 0.0005 19.2 0.0 0.00095 18.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase2 PF12740.2 EFE42105.1 - 0.00065 18.6 0.0 0.00096 18.1 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme Thioesterase PF00975.15 EFE42105.1 - 0.0011 19.2 0.5 0.013 15.7 0.3 2.2 1 1 0 1 1 1 1 Thioesterase domain DUF2305 PF10230.4 EFE42105.1 - 0.003 17.0 0.0 0.0051 16.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_3 PF07859.8 EFE42105.1 - 0.0036 16.9 0.0 0.007 15.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFE42105.1 - 0.0047 16.7 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Lipase_3 PF01764.20 EFE42105.1 - 0.0076 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase PF07224.6 EFE42105.1 - 0.0082 14.9 0.0 0.011 14.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_2 PF02230.11 EFE42105.1 - 0.032 13.6 0.0 2.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 EFE42105.1 - 0.041 13.0 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family Spo7 PF03907.8 EFE42106.1 - 5e-65 219.0 0.0 9.6e-65 218.0 0.0 1.4 1 1 0 1 1 1 1 Spo7-like protein YL1 PF05764.8 EFE42106.1 - 0.65 9.5 5.0 1.4 8.5 3.5 1.5 1 1 0 1 1 1 0 YL1 nuclear protein HNH_2 PF13391.1 EFE42107.1 - 0.00031 20.4 0.0 0.00064 19.4 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease Cys_rich_CPXG PF14255.1 EFE42107.1 - 0.16 11.7 0.1 0.4 10.5 0.0 1.5 1 0 0 1 1 1 0 Cysteine-rich CPXCG MCM PF00493.18 EFE42108.1 - 2.9e-130 433.8 0.3 4e-130 433.4 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 EFE42108.1 - 4.7e-07 29.1 0.0 8e-06 25.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EFE42108.1 - 0.0026 17.3 0.0 0.0059 16.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFE42108.1 - 0.053 13.0 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF4611 PF15387.1 EFE42108.1 - 0.24 11.5 10.7 0.8 9.8 1.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Peptidase_S64 PF08192.6 EFE42108.1 - 1 7.6 6.4 1.5 7.0 4.4 1.2 1 0 0 1 1 1 0 Peptidase family S64 PPR_2 PF13041.1 EFE42109.1 - 4.7e-20 71.3 4.7 2.3e-09 37.0 0.0 6.4 4 2 2 6 6 6 5 PPR repeat family PPR_3 PF13812.1 EFE42109.1 - 7.9e-20 69.4 4.3 0.00013 21.9 0.0 9.3 8 0 0 8 8 8 5 Pentatricopeptide repeat domain PPR PF01535.15 EFE42109.1 - 2.2e-19 67.9 2.1 2.8e-05 23.7 0.0 8.6 8 0 0 8 8 8 5 PPR repeat PPR_1 PF12854.2 EFE42109.1 - 7.5e-08 31.7 0.0 0.16 11.4 0.0 5.6 6 0 0 6 6 6 3 PPR repeat Nucleoplasmin PF03066.10 EFE42111.1 - 0.0053 16.2 0.2 0.0053 16.2 0.1 1.2 1 0 0 1 1 1 1 Nucleoplasmin RRP7 PF12923.2 EFE42112.1 - 8e-31 106.7 8.3 8e-31 106.7 5.7 2.2 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) RRM_1 PF00076.17 EFE42112.1 - 0.058 13.0 0.0 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4611 PF15387.1 EFE42112.1 - 1.1 9.4 7.1 9.6 6.4 1.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Rad51 PF08423.6 EFE42113.1 - 5.4e-59 199.1 0.2 7.2e-58 195.4 0.1 2.1 1 1 0 1 1 1 1 Rad51 HHH_5 PF14520.1 EFE42113.1 - 1.5e-08 34.6 0.3 4e-08 33.3 0.2 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain UDPGP PF01704.13 EFE42114.1 - 1.2e-56 192.0 0.0 1.7e-56 191.5 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 EFE42114.1 - 0.0092 16.0 0.0 0.033 14.2 0.0 1.9 2 0 0 2 2 2 1 MobA-like NTP transferase domain Fer4_20 PF14691.1 EFE42114.1 - 0.041 13.5 0.0 0.085 12.4 0.0 1.5 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster PmbA_TldD PF01523.11 EFE42114.1 - 0.089 12.0 0.6 1.4 8.0 0.1 2.3 2 0 0 2 2 2 0 Putative modulator of DNA gyrase DUF3007 PF11460.3 EFE42114.1 - 0.14 12.2 0.4 0.34 10.9 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) Pro_isomerase PF00160.16 EFE42115.1 - 1.6e-20 73.8 0.0 1.7e-17 64.0 0.0 2.3 1 1 1 2 2 2 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.17 EFE42115.1 - 5.6e-16 57.9 0.1 4.4e-15 55.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE42115.1 - 3.4e-12 46.1 0.0 8.1e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE42115.1 - 1.6e-09 37.4 0.3 5.4e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE42115.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ribosomal_S24e PF01282.14 EFE42117.1 - 9e-31 105.5 0.0 1.6e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e ALAD PF00490.16 EFE42117.1 - 0.092 11.6 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Delta-aminolevulinic acid dehydratase Methyltransf_16 PF10294.4 EFE42118.1 - 9e-21 74.0 0.0 1.2e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EFE42118.1 - 1.5e-07 31.9 0.0 3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFE42118.1 - 5.8e-05 22.3 0.0 7.4e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EFE42118.1 - 0.00056 19.3 0.0 0.00093 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 EFE42118.1 - 0.0035 17.7 0.0 0.0059 17.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE42118.1 - 0.0047 17.3 0.0 0.0088 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE42118.1 - 0.0058 16.6 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EFE42118.1 - 0.01 14.8 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TehB PF03848.9 EFE42118.1 - 0.015 14.5 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_23 PF13489.1 EFE42118.1 - 0.017 14.8 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.11 EFE42118.1 - 0.019 14.5 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein DUF938 PF06080.7 EFE42118.1 - 0.023 14.2 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_31 PF13847.1 EFE42118.1 - 0.085 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EFE42118.1 - 0.19 11.2 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) adh_short PF00106.20 EFE42119.1 - 1.4e-14 54.3 0.0 1.8e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE42119.1 - 3.5e-05 23.5 0.0 4.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE42119.1 - 0.00034 20.4 0.0 0.00047 19.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Pro-kuma_activ PF09286.6 EFE42120.1 - 7e-37 126.6 0.0 2.5e-36 124.8 0.0 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFE42120.1 - 0.0015 17.7 0.2 0.0068 15.5 0.0 1.8 2 0 0 2 2 2 1 Subtilase family DUF2306 PF10067.4 EFE42121.1 - 1.3e-10 41.3 7.3 1.3e-10 41.3 5.1 1.9 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) SAC3_GANP PF03399.11 EFE42122.1 - 9.9e-26 90.5 0.0 1.4e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 EFE42122.1 - 3.2e-21 75.5 0.0 6.5e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 WD40 PF00400.27 EFE42123.1 - 0.0007 19.3 0.0 2.5 8.1 0.0 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat BBS2_Mid PF14783.1 EFE42123.1 - 0.049 13.4 0.0 10 5.9 0.0 3.4 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Vps51 PF08700.6 EFE42124.1 - 7.7e-25 86.5 0.0 1.6e-24 85.5 0.0 1.6 1 0 0 1 1 1 1 Vps51/Vps67 COG5 PF10392.4 EFE42124.1 - 0.0014 18.6 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Dor1 PF04124.7 EFE42124.1 - 0.041 12.3 0.1 0.049 12.0 0.1 1.1 1 0 0 1 1 1 0 Dor1-like family Fes1 PF08609.5 EFE42124.1 - 0.042 14.3 0.1 0.53 10.7 0.0 2.2 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 DUF1767 PF08585.7 EFE42125.1 - 6.3e-17 61.6 0.1 2.4e-16 59.7 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1767) TPR_11 PF13414.1 EFE42126.1 - 2.4e-41 139.1 40.7 8.5e-08 31.7 0.0 12.5 12 1 1 14 14 13 8 TPR repeat TPR_17 PF13431.1 EFE42126.1 - 3.3e-24 83.0 13.9 0.02 15.0 0.0 13.4 13 0 0 13 13 13 5 Tetratricopeptide repeat TPR_2 PF07719.12 EFE42126.1 - 1e-17 62.5 46.7 0.021 14.7 0.1 15.9 17 0 0 17 17 16 5 Tetratricopeptide repeat TPR_16 PF13432.1 EFE42126.1 - 1.2e-17 64.0 46.1 0.0028 18.2 0.1 13.2 12 2 2 14 14 14 6 Tetratricopeptide repeat TPR_12 PF13424.1 EFE42126.1 - 3.1e-17 62.2 32.2 0.00064 19.6 0.2 11.3 10 1 3 13 13 13 7 Tetratricopeptide repeat TPR_14 PF13428.1 EFE42126.1 - 1.4e-16 59.4 37.3 0.061 13.9 0.0 15.5 13 4 5 18 18 15 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFE42126.1 - 3.4e-15 54.8 38.2 0.16 11.6 0.0 13.6 14 1 0 14 14 14 7 Tetratricopeptide repeat TPR_19 PF14559.1 EFE42126.1 - 4e-14 52.7 19.8 0.0012 19.0 0.3 10.2 6 4 4 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.1 EFE42126.1 - 4.9e-12 44.7 22.1 2.7 7.9 1.5 11.0 11 1 1 12 12 9 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFE42126.1 - 2.9e-05 23.5 13.4 3.4 7.6 0.0 9.5 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFE42126.1 - 3.8e-05 23.8 26.7 0.34 11.4 0.2 12.8 16 0 0 16 16 16 2 Tetratricopeptide repeat Apc5 PF12862.2 EFE42126.1 - 0.03 14.1 2.8 0.82 9.5 0.0 4.3 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 5 TPR_9 PF13371.1 EFE42126.1 - 0.035 13.9 5.7 24 4.8 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.5 EFE42126.1 - 0.042 12.6 4.3 15 4.2 0.1 5.0 5 1 0 6 6 6 0 ChAPs (Chs5p-Arf1p-binding proteins) Cellulase PF00150.13 EFE42127.1 - 6.2e-08 32.1 3.8 5.5e-06 25.7 1.0 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.10 EFE42127.1 - 0.023 13.8 0.1 5.9 5.9 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase Xpo1 PF08389.7 EFE42128.1 - 8.7e-08 32.2 12.5 1e-07 31.9 2.7 4.0 3 1 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.14 EFE42128.1 - 0.0004 20.2 1.4 0.11 12.4 0.0 4.1 4 0 0 4 4 4 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 EFE42128.1 - 0.095 12.9 0.6 11 6.3 0.1 3.5 3 0 0 3 3 3 0 HEAT repeats BON PF04972.12 EFE42128.1 - 0.12 12.0 0.2 0.31 10.8 0.2 1.6 1 0 0 1 1 1 0 BON domain GRIM-19 PF06212.7 EFE42129.1 - 1.2e-06 28.2 0.1 1.5e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 GRIM-19 protein tRNA_m1G_MT PF01746.16 EFE42130.1 - 5.3e-31 107.6 3.1 2.3e-30 105.5 0.0 2.6 2 1 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase Rsc14 PF08586.5 EFE42130.1 - 0.35 11.3 2.0 1.1 9.8 1.4 1.8 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit VID27 PF08553.5 EFE42131.1 - 0 1140.2 0.2 0 1140.1 0.1 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein Usp PF00582.21 EFE42131.1 - 4.9 7.3 5.8 30 4.7 0.0 2.8 2 0 0 2 2 2 0 Universal stress protein family TLD PF07534.11 EFE42132.1 - 1.3e-23 83.5 0.0 6.7e-15 55.3 0.0 2.3 2 0 0 2 2 2 2 TLD Adaptin_N PF01602.15 EFE42133.1 - 1.1e-139 466.2 3.0 1.2e-139 465.9 2.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EFE42133.1 - 1.3e-30 106.6 0.1 2.1e-27 96.1 0.1 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EFE42133.1 - 1.4e-18 66.9 2.6 1.1e-06 28.8 0.0 5.4 3 3 3 6 6 6 3 HEAT repeats HEAT PF02985.17 EFE42133.1 - 6.6e-12 44.4 0.3 0.012 15.5 0.0 5.6 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.1 EFE42133.1 - 6.2e-05 23.3 3.3 1 9.9 0.0 6.3 7 1 0 7 7 7 1 HEAT-like repeat CLASP_N PF12348.3 EFE42133.1 - 0.0019 17.6 0.2 1.4 8.2 0.0 3.4 2 1 1 3 3 3 2 CLASP N terminal Arm PF00514.18 EFE42133.1 - 0.0043 16.8 3.7 5.7 6.9 0.0 5.6 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Cohesin_HEAT PF12765.2 EFE42133.1 - 0.032 14.1 0.1 5.7 7.0 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Ribosomal_60s PF00428.14 EFE42133.1 - 4.1 7.8 8.0 5.5 7.4 3.4 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein DEK_C PF08766.6 EFE42134.1 - 0.0014 18.3 0.1 0.0044 16.7 0.1 1.8 1 0 0 1 1 1 1 DEK C terminal domain Evr1_Alr PF04777.8 EFE42135.1 - 1.4e-26 92.1 3.1 3e-26 91.1 2.2 1.5 1 0 0 1 1 1 1 Erv1 / Alr family Herpes_capsid PF06112.6 EFE42135.1 - 0.83 9.6 4.4 1.3 9.0 3.0 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Coatomer_WDAD PF04053.9 EFE42136.1 - 7.7e-146 486.3 0.0 1.1e-145 485.7 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 EFE42136.1 - 4.1e-91 305.6 0.4 2.3e-90 303.1 0.3 1.9 1 1 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 EFE42136.1 - 7e-46 152.5 13.7 9.5e-09 34.8 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat Clathrin PF00637.15 EFE42136.1 - 0.0019 17.8 0.1 0.09 12.3 0.0 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS Nup160 PF11715.3 EFE42136.1 - 0.0021 16.3 5.7 0.23 9.5 0.0 3.5 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Phytase-like PF13449.1 EFE42138.1 - 3.4e-28 98.8 0.1 4.9e-28 98.3 0.1 1.4 1 1 0 1 1 1 1 Esterase-like activity of phytase SdiA-regulated PF06977.6 EFE42138.1 - 0.05 12.5 0.1 0.53 9.1 0.0 2.5 3 0 0 3 3 3 0 SdiA-regulated Clr5 PF14420.1 EFE42140.1 - 1.3e-05 24.9 0.1 5.2e-05 23.0 0.1 2.1 1 1 0 1 1 1 1 Clr5 domain TAXi_C PF14541.1 EFE42140.1 - 0.12 11.9 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Sensor PF13796.1 EFE42140.1 - 0.7 9.4 2.0 1.4 8.5 1.4 1.4 1 0 0 1 1 1 0 Putative sensor Het-C PF07217.6 EFE42141.1 - 6.1e-266 883.4 0.0 8.7e-266 882.9 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C PigN PF04987.9 EFE42141.1 - 0.65 8.5 0.6 1 7.9 0.4 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DUF2828 PF11443.3 EFE42142.1 - 2e-166 554.3 0.7 2.9e-166 553.8 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) FAD-oxidase_C PF02913.14 EFE42143.1 - 1.3e-48 165.5 0.2 2.2e-48 164.7 0.1 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EFE42143.1 - 4e-36 123.5 0.0 6.7e-36 122.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Glyco_hydro_2 PF00703.16 EFE42144.1 - 1.7e-12 47.7 0.0 4.2e-12 46.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.13 EFE42144.1 - 9.3e-10 38.3 0.0 2e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 EFE42144.1 - 4.4e-08 32.3 0.1 8.4e-08 31.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain ADH_zinc_N PF00107.21 EFE42145.1 - 1.2e-24 86.2 0.1 2.1e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 EFE42145.1 - 1.2e-05 25.8 0.0 1.9e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.1 EFE42145.1 - 0.00018 22.3 0.3 0.0007 20.4 0.1 1.9 1 1 1 2 2 2 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 EFE42145.1 - 0.0078 15.6 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.16 EFE42145.1 - 0.019 14.5 0.2 0.03 13.8 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.9 EFE42145.1 - 0.033 12.6 0.2 0.048 12.1 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Methyltransf_31 PF13847.1 EFE42145.1 - 0.051 13.1 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EFE42145.1 - 0.051 12.6 0.0 0.068 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 EFE42145.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain AdoHcyase_NAD PF00670.16 EFE42145.1 - 0.18 11.6 0.9 0.26 11.1 0.2 1.5 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain zf-B_box PF00643.19 EFE42146.1 - 2 8.3 12.1 6.7 6.6 8.4 1.9 1 0 0 1 1 1 0 B-box zinc finger KAR9 PF08580.5 EFE42147.1 - 1.5e-122 410.2 1.0 1.5e-122 410.2 0.7 2.6 2 1 0 2 2 2 1 Yeast cortical protein KAR9 Tim17 PF02466.14 EFE42147.1 - 0.057 13.4 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family HALZ PF02183.13 EFE42147.1 - 3.1 7.5 4.9 4.7 6.9 0.1 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper CDC45 PF02724.9 EFE42148.1 - 0.068 11.1 9.7 0.085 10.8 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF912 PF06024.7 EFE42148.1 - 0.1 12.6 3.8 0.23 11.5 2.6 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Hid1 PF12722.2 EFE42148.1 - 1.1 6.8 8.1 1.4 6.5 5.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med25_SD1 PF11235.3 EFE42148.1 - 1.8 8.8 6.8 0.35 11.1 1.5 2.0 2 0 0 2 2 2 0 Mediator complex subunit 25 synapsin 1 Secretin_N_2 PF07655.8 EFE42148.1 - 3.8 7.9 16.6 0.14 12.5 7.1 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain CRAL_TRIO PF00650.15 EFE42149.1 - 2.9e-36 124.3 0.0 4.4e-36 123.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 EFE42149.1 - 0.00056 19.8 0.0 0.0045 16.8 0.0 2.1 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain AOX PF01786.12 EFE42151.1 - 6.4e-91 303.3 0.0 7.3e-91 303.1 0.0 1.0 1 0 0 1 1 1 1 Alternative oxidase adh_short PF00106.20 EFE42152.1 - 3.1e-16 59.7 0.0 4.1e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE42152.1 - 6e-09 36.0 0.0 7.5e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE42152.1 - 1.9e-06 27.6 0.0 2.7e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE42152.1 - 0.0013 18.2 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 EFE42152.1 - 0.0072 15.4 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.3 EFE42152.1 - 0.03 14.1 0.0 0.069 12.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3HCDH_N PF02737.13 EFE42152.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MBOAT PF03062.14 EFE42153.1 - 6.6e-47 160.2 12.3 1.4e-46 159.1 8.5 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family FA_desaturase PF00487.19 EFE42154.1 - 1.1e-33 116.7 22.6 1.9e-33 116.0 15.7 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 EFE42154.1 - 5.7e-10 38.8 0.0 1.2e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Dopey_N PF04118.9 EFE42155.1 - 4.8e-123 409.8 0.0 5.6e-122 406.3 0.0 2.4 2 0 0 2 2 2 1 Dopey, N-terminal Mon1 PF03164.9 EFE42156.1 - 2.1e-93 313.1 0.0 2.7e-93 312.8 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 HRDC PF00570.18 EFE42157.1 - 2.3e-09 36.8 0.0 3.7e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 HRDC domain PGA2 PF07543.7 EFE42159.1 - 0.83 9.4 3.9 0.8 9.4 2.7 1.0 1 0 0 1 1 1 0 Protein trafficking PGA2 ZZ PF00569.12 EFE42160.1 - 1.8e-14 52.9 39.1 1e-06 28.1 6.3 3.4 3 0 0 3 3 3 3 Zinc finger, ZZ type LETM1 PF07766.8 EFE42161.1 - 5.3e-08 32.2 0.1 5.1e-05 22.4 0.0 2.2 2 0 0 2 2 2 2 LETM1-like protein DUF4526 PF15029.1 EFE42161.1 - 1.4 8.4 5.5 1.4 8.4 2.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4526) NTP_transf_2 PF01909.18 EFE42162.1 - 0.0029 17.8 0.0 0.0059 16.9 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Glyco_hydro_44 PF12891.2 EFE42162.1 - 0.004 16.6 0.0 0.0063 16.0 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase family 44 Glyco_transf_20 PF00982.16 EFE42163.1 - 5.9e-149 496.5 0.0 9.9e-149 495.8 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EFE42163.1 - 2.4e-89 298.2 0.0 5.1e-89 297.2 0.0 1.5 2 0 0 2 2 2 1 Trehalose-phosphatase HAD PF12710.2 EFE42163.1 - 0.032 14.3 0.1 0.29 11.2 0.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Glyco_trans_1_4 PF13692.1 EFE42163.1 - 0.083 13.0 0.0 0.99 9.5 0.0 2.7 2 1 1 3 3 3 0 Glycosyl transferases group 1 Acetyltransf_1 PF00583.19 EFE42164.1 - 2e-17 63.0 0.0 2.8e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFE42164.1 - 2.7e-06 27.0 0.0 4.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EFE42164.1 - 5.7e-06 26.4 0.0 7.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFE42164.1 - 3e-05 24.0 0.0 5.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFE42164.1 - 0.00033 20.4 0.0 0.00055 19.7 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.1 EFE42164.1 - 0.011 15.6 0.0 0.087 12.7 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFE42164.1 - 0.02 14.7 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFE42164.1 - 0.059 13.5 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 EFE42164.1 - 0.082 12.5 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE42164.1 - 0.15 11.9 0.0 0.96 9.3 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.11 EFE42165.1 - 2.6e-17 62.5 41.5 2.6e-17 62.5 28.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RepA1_leader PF08048.7 EFE42166.1 - 0.21 11.6 3.8 5 7.2 1.3 2.2 2 0 0 2 2 2 0 Tap RepA1 leader peptide PP28 PF10252.4 EFE42167.1 - 5.2e-30 103.3 21.1 5.2e-30 103.3 14.6 3.8 2 2 1 3 3 3 1 Casein kinase substrate phosphoprotein PP28 MFS_1 PF07690.11 EFE42168.1 - 8e-34 116.8 27.8 1.7e-33 115.8 19.4 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1049 PF06305.6 EFE42168.1 - 4.6 6.8 0.0 4.6 6.8 0.0 4.0 4 1 1 5 5 5 0 Protein of unknown function (DUF1049) PMP22_Claudin PF00822.15 EFE42169.1 - 0.11 12.0 2.7 0.16 11.6 0.5 2.1 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.1 EFE42169.1 - 0.23 11.1 7.8 0.052 13.2 0.4 2.2 1 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction FAD_binding_3 PF01494.14 EFE42170.1 - 6e-16 58.4 0.0 5e-06 25.8 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 EFE42170.1 - 5.6e-07 29.4 0.1 1.2e-06 28.4 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFE42170.1 - 7.3e-07 29.5 0.0 0.00016 22.0 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFE42170.1 - 3.3e-05 22.9 0.0 4.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFE42170.1 - 0.0038 17.1 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFE42170.1 - 0.0092 14.8 0.0 0.015 14.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain PQQ PF01011.16 EFE42170.1 - 0.035 13.6 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 PQQ enzyme repeat Lycopene_cycl PF05834.7 EFE42170.1 - 0.055 12.3 0.1 0.27 10.1 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.13 EFE42170.1 - 0.096 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.13 EFE42170.1 - 0.11 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.1 EFE42170.1 - 0.12 12.3 0.1 0.38 10.7 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 EFE42170.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.9 EFE42170.1 - 0.15 10.4 0.1 0.45 8.9 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein COesterase PF00135.23 EFE42172.1 - 6.3e-76 256.1 0.0 9.4e-76 255.6 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE42172.1 - 0.021 14.4 0.2 0.053 13.0 0.2 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Sec7 PF01369.15 EFE42174.1 - 1.1e-38 132.8 0.0 2.3e-38 131.7 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 EFE42174.1 - 2.1e-19 69.8 0.6 4.9e-19 68.6 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Lzipper-MIP1 PF14389.1 EFE42174.1 - 0.038 14.0 0.2 0.091 12.8 0.2 1.6 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Mto2_bdg PF12808.2 EFE42175.1 - 2.4e-28 97.9 32.4 3.7e-19 68.5 14.0 9.9 10 2 2 12 12 12 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Microtub_assoc PF07989.6 EFE42175.1 - 6.5e-22 77.1 9.3 6.5e-22 77.1 6.4 7.5 6 1 1 8 8 8 1 Microtubule associated Reo_sigmaC PF04582.7 EFE42175.1 - 0.0014 17.8 3.7 0.0014 17.8 2.6 5.6 4 1 3 7 7 7 4 Reovirus sigma C capsid protein Fib_alpha PF08702.5 EFE42175.1 - 0.0028 17.8 8.1 0.0028 17.8 5.6 8.0 3 1 6 10 10 10 4 Fibrinogen alpha/beta chain family QRPTase_C PF01729.14 EFE42176.1 - 2.8e-48 163.6 0.7 6.2e-26 90.9 0.1 2.0 1 1 1 2 2 2 2 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 EFE42176.1 - 1.7e-11 43.7 0.0 5.8e-11 42.0 0.0 1.9 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain LysR_substrate PF03466.15 EFE42176.1 - 0.033 13.2 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 LysR substrate binding domain SWI-SNF_Ssr4 PF08549.5 EFE42176.1 - 0.051 11.8 0.4 0.058 11.6 0.3 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF768 PF05589.6 EFE42176.1 - 0.14 12.1 2.4 2.4 8.1 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF768) Glyoxalase_2 PF12681.2 EFE42177.1 - 3.6e-13 50.0 0.0 4.5e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 EFE42177.1 - 5.3e-05 23.1 0.0 0.00014 21.8 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EFE42177.1 - 0.044 13.7 0.0 0.38 10.7 0.0 2.0 1 1 1 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Aldose_epim PF01263.15 EFE42178.1 - 7.8e-58 195.9 0.0 8.7e-58 195.7 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Zn_clus PF00172.13 EFE42179.1 - 6.1e-09 35.6 10.7 9e-09 35.1 7.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nucleoplasmin PF03066.10 EFE42180.1 - 0.34 10.4 6.2 0.43 10.0 4.3 1.1 1 0 0 1 1 1 0 Nucleoplasmin NOA36 PF06524.7 EFE42180.1 - 0.45 9.7 4.3 0.51 9.5 3.0 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.4 EFE42180.1 - 0.59 8.7 10.1 0.69 8.5 7.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.6 EFE42180.1 - 0.6 9.9 2.3 0.76 9.5 1.6 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.5 EFE42180.1 - 0.81 9.9 12.2 1.2 9.4 8.5 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 EFE42180.1 - 3 7.4 5.6 3.6 7.1 3.9 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 EFE42180.1 - 4.6 7.6 8.7 7.6 6.9 6.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.7 EFE42180.1 - 6.6 4.5 7.0 7.7 4.3 4.9 1.0 1 0 0 1 1 1 0 Nop14-like family Ras PF00071.17 EFE42181.1 - 1.3e-12 47.3 0.0 6.4e-06 25.6 0.0 2.1 2 0 0 2 2 2 2 Ras family Miro PF08477.8 EFE42181.1 - 0.034 14.6 0.0 0.099 13.1 0.0 1.8 2 0 0 2 2 2 0 Miro-like protein Peptidase_S41 PF03572.13 EFE42182.1 - 3.1e-08 33.2 0.0 6.8e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 Peptidase family S41 DUF3608 PF12257.3 EFE42182.1 - 0.29 9.9 0.0 0.49 9.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3608) BSMAP PF12280.3 EFE42184.1 - 0.24 11.2 2.7 0.27 11.1 1.8 1.0 1 0 0 1 1 1 0 Brain specific membrane anchored protein DUF4337 PF14235.1 EFE42184.1 - 1.2 8.9 4.3 1.6 8.5 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) GRAB PF10375.4 EFE42185.1 - 2.2e-07 30.2 0.3 4.6e-07 29.2 0.2 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Reo_sigmaC PF04582.7 EFE42185.1 - 0.002 17.3 12.9 0.017 14.3 4.7 2.2 1 1 1 2 2 2 2 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 EFE42185.1 - 0.0059 16.4 13.3 0.75 9.6 4.4 3.1 2 1 1 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.3 EFE42185.1 - 0.62 7.3 47.8 0.61 7.3 23.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.7 EFE42185.1 - 1.6 8.4 52.7 4.9 6.9 7.9 4.7 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein FliJ PF02050.11 EFE42185.1 - 1.9 8.5 47.0 0.082 12.9 12.6 3.7 1 1 2 3 3 3 0 Flagellar FliJ protein GAS PF13851.1 EFE42185.1 - 2.6 7.2 50.8 0.28 10.3 4.6 3.5 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF2576 PF10845.3 EFE42185.1 - 3.6 6.8 6.1 8.4 5.6 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2576) Fib_alpha PF08702.5 EFE42185.1 - 4.9 7.2 27.3 0.85 9.7 1.2 3.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.7 EFE42185.1 - 5.1 7.4 12.6 12 6.2 0.3 4.5 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.6 EFE42185.1 - 9.4 6.1 30.0 0.074 12.9 3.9 3.5 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Guanylate_kin PF00625.16 EFE42186.1 - 7.3e-46 155.9 0.0 9e-46 155.6 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase Septin PF00735.13 EFE42187.1 - 1.7e-112 375.0 0.6 2e-112 374.8 0.4 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EFE42187.1 - 6.5e-07 29.3 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 EFE42187.1 - 4.1e-06 26.0 0.0 7e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family DUF258 PF03193.11 EFE42187.1 - 3.4e-05 23.0 0.0 6.4e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EFE42187.1 - 0.00056 19.7 0.5 1.2 8.8 0.0 2.5 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.22 EFE42187.1 - 0.00095 18.6 0.4 0.017 14.5 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 EFE42187.1 - 0.0041 16.5 0.0 0.0057 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 EFE42187.1 - 0.012 15.8 0.0 0.023 14.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EFE42187.1 - 0.012 15.9 0.2 0.028 14.7 0.1 1.6 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.17 EFE42187.1 - 0.015 14.1 0.1 0.026 13.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_23 PF13476.1 EFE42187.1 - 0.016 15.5 0.0 0.024 14.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain T2SE PF00437.15 EFE42187.1 - 0.023 13.6 0.1 0.072 11.9 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.1 EFE42187.1 - 0.043 13.7 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Gtr1_RagA PF04670.7 EFE42187.1 - 0.046 12.8 0.1 0.13 11.4 0.0 1.8 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.13 EFE42187.1 - 0.053 12.9 0.0 0.092 12.2 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 EFE42187.1 - 0.11 12.0 0.1 0.33 10.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.2 EFE42187.1 - 0.12 11.3 0.0 13 4.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region D3 Ribosomal_L32p PF01783.18 EFE42188.1 - 1e-12 47.9 5.9 1.5e-12 47.4 4.1 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family DZR PF12773.2 EFE42188.1 - 0.014 15.1 0.5 0.021 14.6 0.4 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.7 EFE42188.1 - 0.06 13.1 0.3 0.091 12.5 0.2 1.3 1 0 0 1 1 1 0 zinc-ribbons zf-ribbon_3 PF13248.1 EFE42188.1 - 0.086 12.0 4.9 0.18 11.0 3.4 1.5 1 1 0 1 1 1 0 zinc-ribbon domain Atg14 PF10186.4 EFE42188.1 - 0.69 8.7 5.3 0.2 10.6 1.9 1.4 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 WD40 PF00400.27 EFE42189.1 - 6.6e-28 95.5 5.3 3.6e-12 45.6 0.1 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 EFE42189.1 - 0.002 17.8 0.2 0.034 13.8 0.0 2.5 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 EFE42189.1 - 0.0053 14.9 0.3 0.35 8.9 0.0 2.3 2 1 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFE42189.1 - 0.071 11.8 0.0 0.28 9.8 0.0 1.8 2 0 0 2 2 2 0 Nup133 N terminal like Cytochrom_D1 PF02239.11 EFE42189.1 - 0.085 11.1 0.0 2.8 6.1 0.0 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain Spindle_Spc25 PF08234.7 EFE42190.1 - 6.5e-23 80.5 0.1 3.7e-22 78.1 0.0 2.2 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 Bacillus_HBL PF05791.6 EFE42190.1 - 0.044 13.1 7.0 0.065 12.6 4.8 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF4140 PF13600.1 EFE42190.1 - 0.25 11.8 5.7 5.4 7.5 5.5 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FUSC PF04632.7 EFE42190.1 - 1.1 7.5 6.7 1.3 7.3 4.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF334 PF03904.8 EFE42190.1 - 1.6 7.9 10.5 2.3 7.4 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) DUF3523 PF12037.3 EFE42190.1 - 2.3 7.1 19.4 3.2 6.6 13.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Atg14 PF10186.4 EFE42190.1 - 4.1 6.2 18.3 5.8 5.7 12.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Cortex-I_coil PF09304.5 EFE42190.1 - 5.6 7.0 19.3 11 6.0 6.3 2.4 1 1 1 2 2 2 0 Cortexillin I, coiled coil Rrn6 PF10214.4 EFE42191.1 - 1.2e-103 347.7 0.1 1.4e-103 347.5 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor zinc_ribbon_6 PF14599.1 EFE42192.1 - 5.6e-19 67.7 0.0 8.1e-19 67.1 0.0 1.2 1 0 0 1 1 1 1 Zinc-ribbon Nucleoplasmin PF03066.10 EFE42192.1 - 0.018 14.5 1.5 0.022 14.2 1.0 1.2 1 0 0 1 1 1 0 Nucleoplasmin CENP-B_dimeris PF09026.5 EFE42192.1 - 4.7 7.5 11.6 9.9 6.4 8.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Phlebovirus_NSM PF07246.6 EFE42194.1 - 0.0013 17.9 4.0 0.0022 17.1 2.8 1.4 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M CENP-F_leu_zip PF10473.4 EFE42194.1 - 0.0028 17.5 1.4 0.0028 17.5 1.0 3.3 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.1 EFE42194.1 - 0.0032 16.6 15.8 0.14 11.3 4.9 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding WES_acyltransf PF03007.11 EFE42194.1 - 0.011 15.3 0.7 0.02 14.4 0.3 1.6 1 1 1 2 2 2 0 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF2968 PF11180.3 EFE42194.1 - 0.011 15.1 14.6 0.32 10.3 4.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF904 PF06005.7 EFE42194.1 - 0.014 15.6 1.5 0.014 15.6 1.0 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF3450 PF11932.3 EFE42194.1 - 0.052 12.8 6.7 0.09 12.0 4.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HALZ PF02183.13 EFE42194.1 - 0.086 12.5 2.2 0.23 11.1 0.1 2.8 2 1 1 3 3 3 0 Homeobox associated leucine zipper DivIC PF04977.10 EFE42194.1 - 0.1 12.1 9.3 0.28 10.6 0.2 3.2 1 1 2 3 3 3 0 Septum formation initiator KaiC PF06745.8 EFE42194.1 - 0.21 10.6 4.2 0.37 9.8 2.4 1.8 1 1 1 2 2 2 0 KaiC APG6 PF04111.7 EFE42194.1 - 0.69 8.8 13.9 1.1 8.1 9.7 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IFP_35_N PF07334.8 EFE42194.1 - 1.2 9.1 6.0 3.9 7.5 0.0 3.7 2 1 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus ADIP PF11559.3 EFE42194.1 - 2 8.3 20.5 0.25 11.2 3.2 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding bZIP_Maf PF03131.12 EFE42194.1 - 2.3 8.5 12.3 5.3 7.4 0.1 3.3 2 1 1 3 3 3 0 bZIP Maf transcription factor FUSC PF04632.7 EFE42194.1 - 2.4 6.4 3.2 3.1 6.1 2.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Tnp_P_element PF12017.3 EFE42194.1 - 3.3 6.8 9.6 7 5.8 1.9 2.5 1 1 2 3 3 3 0 Transposase protein TMF_DNA_bd PF12329.3 EFE42194.1 - 3.3 7.5 11.4 0.75 9.6 1.5 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding IncA PF04156.9 EFE42194.1 - 3.6 7.1 20.4 18 4.8 14.2 1.9 1 1 0 1 1 1 0 IncA protein DUF972 PF06156.8 EFE42194.1 - 4.4 7.6 14.1 2.4 8.5 2.8 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) KLRAQ PF10205.4 EFE42194.1 - 5.6 7.0 13.8 1.9 8.5 4.5 3.4 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein OST3_OST6 PF04756.8 EFE42195.1 - 5e-22 78.1 2.6 7.6e-22 77.5 1.8 1.2 1 0 0 1 1 1 1 OST3 / OST6 family HABP4_PAI-RBP1 PF04774.10 EFE42196.1 - 0.00014 22.3 2.3 0.0002 21.8 1.6 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family Nucleoporin_C PF03177.9 EFE42197.1 - 5.6e-108 361.9 7.4 7.1e-108 361.6 5.1 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 EFE42197.1 - 9e-46 156.4 0.1 1.3e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like DWNN PF08783.6 EFE42198.1 - 3.6e-33 113.3 0.1 8.8e-33 112.0 0.1 1.7 1 0 0 1 1 1 1 DWNN domain DUF3905 PF13045.1 EFE42198.1 - 0.039 13.7 1.0 4.8 7.0 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3905) DUF1272 PF06906.6 EFE42198.1 - 0.059 13.2 3.2 0.12 12.2 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_5 PF14634.1 EFE42198.1 - 0.11 12.2 4.3 0.21 11.3 3.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain FYVE_2 PF02318.11 EFE42198.1 - 0.19 11.6 1.8 0.39 10.6 1.2 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger zf-C3HC4_2 PF13923.1 EFE42198.1 - 0.23 11.5 7.1 0.43 10.6 4.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 EFE42198.1 - 0.65 9.6 5.9 1.3 8.6 4.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.20 EFE42198.1 - 1.9 8.2 8.0 3.6 7.3 5.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFE42198.1 - 5 7.0 9.1 11 5.9 6.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Med14 PF08638.6 EFE42199.1 - 2.2e-58 196.7 0.0 3.7e-58 195.9 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 Thioredoxin PF00085.15 EFE42200.1 - 8.9e-69 227.7 8.8 2.3e-32 110.7 0.1 4.4 4 0 0 4 4 4 4 Thioredoxin Thioredoxin_6 PF13848.1 EFE42200.1 - 6.2e-60 202.1 5.3 4.6e-42 143.8 1.1 3.5 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFE42200.1 - 1.7e-11 44.0 0.6 0.0023 17.9 0.0 4.8 4 1 1 5 5 5 2 Thioredoxin-like Thioredoxin_7 PF13899.1 EFE42200.1 - 7e-11 42.0 0.1 0.00038 20.4 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EFE42200.1 - 2.1e-10 40.7 6.6 0.00017 21.7 0.1 4.9 3 2 1 4 4 4 2 Thioredoxin-like domain AhpC-TSA PF00578.16 EFE42200.1 - 1.8e-07 30.9 0.3 0.0015 18.2 0.0 3.0 3 0 0 3 3 3 2 AhpC/TSA family Calsequestrin PF01216.12 EFE42200.1 - 2.6e-06 26.4 4.9 3.4e-06 26.0 2.0 2.0 1 1 1 2 2 2 1 Calsequestrin Redoxin PF08534.5 EFE42200.1 - 1.9e-05 24.2 2.2 0.065 12.7 0.0 3.3 3 0 0 3 3 3 2 Redoxin Thioredoxin_3 PF13192.1 EFE42200.1 - 0.0052 16.5 0.3 0.023 14.4 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_9 PF14595.1 EFE42200.1 - 0.044 13.3 0.1 4.8 6.7 0.0 2.7 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.1 EFE42200.1 - 0.42 10.5 6.4 9.3 6.2 0.0 3.8 4 0 0 4 4 4 0 Thioredoxin Yippee-Mis18 PF03226.9 EFE42201.1 - 2e-16 59.8 0.0 2.9e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SHNi-TPR PF10516.4 EFE42202.1 - 2.9e-16 58.3 2.6 5.9e-14 51.0 0.3 2.7 2 0 0 2 2 2 2 SHNi-TPR TPR_12 PF13424.1 EFE42202.1 - 5.7e-08 32.5 5.7 0.00043 20.1 0.3 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE42202.1 - 3.8e-06 26.4 6.7 7.4e-05 22.3 0.3 3.0 3 0 0 3 3 3 2 TPR repeat TPR_16 PF13432.1 EFE42202.1 - 0.00059 20.4 6.1 0.001 19.6 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFE42202.1 - 0.04 13.8 0.6 1.1 9.2 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Musclin PF11037.3 EFE42202.1 - 0.59 9.7 2.5 0.45 10.1 0.1 2.0 3 0 0 3 3 3 0 Insulin-resistance promoting peptide in skeletal muscle TPR_3 PF07720.7 EFE42202.1 - 6 6.7 7.8 0.88 9.4 0.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DNA_pol_E_B PF04042.11 EFE42203.1 - 8.7e-48 162.3 0.0 1.4e-47 161.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B His_biosynth PF00977.16 EFE42204.1 - 3.5e-44 150.7 0.9 1.3e-43 148.8 0.7 1.9 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 EFE42204.1 - 6.3e-32 110.5 0.0 9.8e-32 109.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.14 EFE42204.1 - 4.4e-12 46.0 0.0 1.8e-11 44.0 0.0 1.9 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 EFE42204.1 - 1.6e-10 40.8 0.0 3.5e-10 39.7 0.0 1.6 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain BPL_N PF09825.4 EFE42204.1 - 0.0036 16.1 0.0 0.41 9.3 0.0 2.2 2 0 0 2 2 2 2 Biotin-protein ligase, N terminal Peptidase_S51 PF03575.12 EFE42204.1 - 0.01 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S51 dCMP_cyt_deam_1 PF00383.17 EFE42205.1 - 2.2e-17 62.5 0.1 3.8e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region ThiF PF00899.16 EFE42206.1 - 7e-27 93.9 0.0 1.4e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 EFE42206.1 - 0.0034 17.4 0.0 0.0076 16.3 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.11 EFE42206.1 - 0.012 15.0 0.0 0.062 12.7 0.0 2.1 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.14 EFE42206.1 - 0.077 12.1 0.0 0.27 10.3 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Toprim PF01751.17 EFE42206.1 - 0.11 12.4 0.0 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Toprim domain UCH PF00443.24 EFE42207.1 - 7.5e-44 149.8 0.0 1.5e-43 148.8 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EFE42207.1 - 8.5e-20 70.6 1.6 8.5e-20 70.6 1.1 2.4 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 EFE42207.1 - 1.4e-18 67.3 0.0 8.2e-10 38.5 0.0 3.1 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.26 EFE42207.1 - 1.5e-14 53.2 0.4 3.1e-07 30.0 0.1 2.5 2 0 0 2 2 2 2 UBA/TS-N domain UBA_4 PF14555.1 EFE42207.1 - 0.0085 15.6 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UPF1_Zn_bind PF09416.5 EFE42207.1 - 0.12 11.9 1.4 0.43 10.1 1.0 1.9 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) UDG PF03167.14 EFE42209.1 - 1.4e-25 89.5 0.1 2.3e-25 88.8 0.1 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily FAM176 PF14851.1 EFE42209.1 - 2.2 7.9 7.4 0.18 11.4 0.6 2.1 2 0 0 2 2 2 0 FAM176 family NifU_N PF01592.11 EFE42210.1 - 8.7e-43 145.2 0.1 1.1e-42 144.9 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain PCI PF01399.22 EFE42211.1 - 7.8e-05 22.9 0.1 0.00025 21.3 0.0 1.9 2 0 0 2 2 2 1 PCI domain Aldedh PF00171.17 EFE42212.1 - 6e-07 28.1 4.9 2e-05 23.1 0.1 2.8 3 0 0 3 3 3 2 Aldehyde dehydrogenase family DUF1487 PF07368.6 EFE42212.1 - 0.022 13.9 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Ribosomal_L18e PF00828.14 EFE42213.1 - 9.2e-27 93.9 0.1 1.4e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Sedlin_N PF04628.8 EFE42214.1 - 5.4e-24 84.5 0.0 6.7e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region RRM_5 PF13893.1 EFE42215.1 - 3e-05 23.7 0.0 4.1e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE42215.1 - 0.00025 20.6 0.1 0.00042 19.8 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 EFE42215.1 - 6 5.2 17.8 7.4 4.9 12.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Mito_carr PF00153.22 EFE42216.1 - 7.6e-66 217.8 2.8 5e-22 77.4 0.0 3.8 3 2 0 3 3 3 3 Mitochondrial carrier protein PXA PF02194.10 EFE42217.1 - 9.1e-37 126.4 0.0 2e-36 125.2 0.0 1.6 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.7 EFE42217.1 - 2e-17 63.2 0.0 4.4e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.19 EFE42217.1 - 4.9e-10 39.2 0.0 1.2e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 PX domain PRELI PF04707.9 EFE42218.1 - 1e-44 151.8 0.3 1.2e-44 151.6 0.2 1.0 1 0 0 1 1 1 1 PRELI-like family CTP_transf_2 PF01467.21 EFE42220.1 - 1.6e-10 41.2 0.1 5.1e-08 33.1 0.0 3.1 3 1 0 3 3 3 2 Cytidylyltransferase CorA PF01544.13 EFE42221.1 - 0.15 11.1 0.1 0.32 9.9 0.1 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein AbiH PF14253.1 EFE42221.1 - 0.18 11.3 0.3 2.8 7.4 0.0 2.0 2 0 0 2 2 2 0 Bacteriophage abortive infection AbiH Fib_alpha PF08702.5 EFE42221.1 - 0.32 11.1 7.3 4.3 7.4 2.8 3.2 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family OmpH PF03938.9 EFE42221.1 - 0.8 9.6 13.4 18 5.2 0.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Glutaredoxin PF00462.19 EFE42222.1 - 4e-15 55.5 0.0 7.3e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Flavoprotein PF02441.14 EFE42223.1 - 2.7e-38 130.5 0.0 3.3e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Flavoprotein UbiA PF01040.13 EFE42224.1 - 3.1e-34 118.3 20.8 4e-34 118.0 14.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family JmjC PF02373.17 EFE42225.1 - 1.8e-08 34.6 0.9 4.6e-07 30.0 0.6 2.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.4 EFE42225.1 - 0.00012 22.1 7.0 0.00012 22.1 4.9 2.7 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.6 EFE42225.1 - 0.0077 15.7 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Coa1 PF08695.5 EFE42226.1 - 3.2e-42 142.7 0.0 4e-42 142.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Ribosomal_L3 PF00297.17 EFE42227.1 - 1.4e-37 129.5 3.0 1e-36 126.7 2.1 1.9 1 1 0 1 1 1 1 Ribosomal protein L3 DUF1279 PF06916.8 EFE42228.1 - 2e-27 95.3 0.1 5.3e-27 93.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) Thioredoxin PF00085.15 EFE42230.1 - 4.4e-28 96.9 0.0 5e-28 96.8 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EFE42230.1 - 9e-07 28.9 0.0 1.2e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 EFE42230.1 - 1.2e-06 28.7 0.4 1.3e-05 25.3 0.3 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EFE42230.1 - 7e-05 22.4 0.0 8.1e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 EFE42230.1 - 0.0016 17.9 0.4 0.011 15.2 0.2 1.8 1 1 1 2 2 2 1 Redoxin Glutaredoxin PF00462.19 EFE42230.1 - 0.0051 16.7 0.2 0.0078 16.1 0.2 1.3 1 0 0 1 1 1 1 Glutaredoxin AhpC-TSA PF00578.16 EFE42230.1 - 0.0057 16.3 0.1 0.13 11.9 0.1 1.9 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_7 PF13899.1 EFE42230.1 - 0.0069 16.3 0.3 0.012 15.6 0.2 1.5 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.1 EFE42230.1 - 0.019 14.4 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.1 EFE42230.1 - 0.02 14.7 0.1 0.022 14.5 0.1 1.1 1 0 0 1 1 1 0 Thioredoxin domain Fer4_15 PF13459.1 EFE42230.1 - 0.042 14.4 1.6 0.084 13.4 1.1 1.7 1 1 0 1 1 1 0 4Fe-4S single cluster domain DUF953 PF06110.6 EFE42230.1 - 0.066 12.6 0.4 0.26 10.7 0.3 1.8 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) HyaE PF07449.6 EFE42230.1 - 0.13 12.1 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE AA_permease_2 PF13520.1 EFE42232.1 - 0.01 14.3 0.4 0.013 14.0 0.3 1.1 1 0 0 1 1 1 0 Amino acid permease DUF1681 PF07933.9 EFE42233.1 - 5.3e-47 159.3 0.0 5.3e-47 159.3 0.0 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1681) RP-C_C PF11800.3 EFE42233.1 - 0.064 12.9 3.4 0.21 11.2 0.1 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region FAM176 PF14851.1 EFE42233.1 - 0.065 12.9 7.9 2.1 8.0 0.3 3.1 3 0 0 3 3 3 0 FAM176 family Rtf2 PF04641.7 EFE42233.1 - 0.092 11.9 3.7 0.33 10.1 0.2 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Peptidase_S49_N PF08496.5 EFE42233.1 - 1.6 8.4 8.5 1.1 9.0 1.1 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Nucleoplasmin PF03066.10 EFE42233.1 - 2.1 7.8 12.4 0.25 10.8 0.7 3.1 3 0 0 3 3 3 0 Nucleoplasmin SR-25 PF10500.4 EFE42233.1 - 2.4 7.5 22.8 0.66 9.3 3.2 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3464 PF11947.3 EFE42233.1 - 2.9 7.3 5.3 5.6 6.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3464) BLVR PF06375.6 EFE42233.1 - 4.1 7.2 17.5 0.085 12.6 2.6 2.9 3 0 0 3 3 3 0 Bovine leukaemia virus receptor (BLVR) IF-2B PF01008.12 EFE42234.1 - 7.1e-51 172.8 0.0 3.5e-50 170.5 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.17 EFE42234.1 - 0.0039 16.8 0.0 0.38 10.3 0.0 2.3 2 0 0 2 2 2 2 DeoR C terminal sensor domain TPR_5 PF12688.2 EFE42234.1 - 0.078 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Tetratrico peptide repeat Nuf2 PF03800.9 EFE42235.1 - 8.4e-44 149.1 0.1 8.4e-44 149.1 0.1 2.2 2 1 0 2 2 2 1 Nuf2 family Reo_sigmaC PF04582.7 EFE42235.1 - 0.35 10.0 10.2 0.88 8.6 3.1 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Atg14 PF10186.4 EFE42235.1 - 1.9 7.3 51.7 4.1 6.2 13.2 2.7 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 CDC45 PF02724.9 EFE42236.1 - 0.057 11.4 2.5 0.067 11.2 1.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2126 PF09899.4 EFE42236.1 - 0.069 11.1 0.2 0.093 10.7 0.1 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CobT PF06213.7 EFE42236.1 - 0.11 11.6 6.3 0.16 11.1 4.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Prog_receptor PF02161.10 EFE42236.1 - 0.17 10.7 1.0 0.21 10.3 0.7 1.1 1 0 0 1 1 1 0 Progesterone receptor BTV_NS2 PF04514.7 EFE42236.1 - 0.17 10.7 2.5 0.23 10.2 1.7 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Sporozoite_P67 PF05642.6 EFE42236.1 - 2.4 5.9 4.3 3 5.5 3.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ribosomal_60s PF00428.14 EFE42236.1 - 2.9 8.3 8.9 0.52 10.7 2.8 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Adaptin_N PF01602.15 EFE42237.1 - 1.8e-97 326.8 0.0 2.2e-97 326.6 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 EFE42237.1 - 1.3e-10 41.4 4.1 0.00032 20.9 0.0 5.0 4 1 2 6 6 6 3 HEAT repeats HEAT PF02985.17 EFE42237.1 - 1.2e-07 31.1 0.4 0.2 11.8 0.0 5.8 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 EFE42237.1 - 0.00098 19.5 5.8 1.1 9.8 0.0 5.5 6 0 0 6 6 6 1 HEAT-like repeat Cohesin_HEAT PF12765.2 EFE42237.1 - 0.0035 17.2 0.2 2 8.4 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.2 EFE42237.1 - 0.019 14.8 0.1 13 5.6 0.0 3.5 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EFE42237.1 - 0.05 13.4 2.0 2 8.3 0.1 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat VHS PF00790.14 EFE42237.1 - 0.074 12.6 1.2 62 3.2 0.0 4.0 5 0 0 5 5 5 0 VHS domain Paf1 PF03985.8 EFE42237.1 - 0.11 11.1 0.0 0.11 11.1 0.0 2.2 2 0 0 2 2 2 0 Paf1 CDC45 PF02724.9 EFE42237.1 - 7 4.5 17.1 15 3.4 11.8 1.5 1 0 0 1 1 1 0 CDC45-like protein Metallophos PF00149.23 EFE42239.1 - 4.2e-42 143.8 0.5 5.7e-42 143.3 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1926 PF09095.6 EFE42239.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1926) Rho_GDI PF02115.12 EFE42240.1 - 1.3e-56 191.2 0.2 1.2e-55 188.0 0.1 1.9 1 1 1 2 2 2 1 RHO protein GDP dissociation inhibitor DUF2313 PF10076.4 EFE42240.1 - 0.054 12.8 0.1 2.2 7.6 0.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2313) GFA PF04828.9 EFE42241.1 - 4.9e-08 32.8 0.3 4.9e-08 32.8 0.2 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme zf-NADH-PPase PF09297.6 EFE42241.1 - 0.0027 17.1 0.1 0.0027 17.1 0.1 2.2 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.1 EFE42241.1 - 0.003 17.2 0.1 0.003 17.2 0.1 2.6 3 0 0 3 3 3 1 Nudix N-terminal zf-ribbon_3 PF13248.1 EFE42241.1 - 0.028 13.6 0.3 0.028 13.6 0.2 2.5 3 0 0 3 3 3 0 zinc-ribbon domain Cys_rich_CWC PF14375.1 EFE42241.1 - 0.075 12.9 0.5 0.075 12.9 0.3 1.9 2 0 0 2 2 2 0 Cysteine-rich CWC zf-CSL PF05207.8 EFE42241.1 - 0.15 11.5 1.3 0.38 10.2 0.4 2.0 2 0 0 2 2 2 0 CSL zinc finger DUF4610 PF15384.1 EFE42242.1 - 5.1 6.5 8.8 0.29 10.6 1.8 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4610) Clp1 PF06807.9 EFE42243.1 - 1.1e-17 64.5 0.0 9.2e-11 41.8 0.0 2.7 2 1 0 2 2 2 2 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 EFE42243.1 - 2.8e-07 30.3 0.0 5.1e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ATP_bind_1 PF03029.12 EFE42243.1 - 6.2e-05 22.6 0.0 0.0023 17.5 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 EFE42243.1 - 0.002 18.0 0.0 0.0087 16.0 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 EFE42243.1 - 0.073 13.3 0.1 0.3 11.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter PduV-EutP PF10662.4 EFE42243.1 - 0.093 12.2 0.0 0.54 9.7 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 EFE42243.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain SRPRB PF09439.5 EFE42243.1 - 0.19 10.9 0.0 0.48 9.6 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Aminotran_5 PF00266.14 EFE42245.1 - 2.5e-11 42.9 0.0 3e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_5 PF00266.14 EFE42246.1 - 3e-78 263.1 0.0 4.2e-78 262.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EFE42246.1 - 5e-08 32.4 0.0 9.5e-08 31.5 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EFE42246.1 - 1.5e-05 24.2 0.0 2.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Copper-bind PF00127.15 EFE42246.1 - 0.0026 17.9 0.2 0.0074 16.4 0.0 1.8 2 0 0 2 2 2 1 Copper binding proteins, plastocyanin/azurin family Pyridoxal_deC PF00282.14 EFE42246.1 - 0.021 13.2 0.0 0.031 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.15 EFE42246.1 - 0.069 11.4 0.0 0.1 10.8 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme ATP_transf PF09830.4 EFE42247.1 - 5.1e-13 48.6 0.5 8.6e-13 47.8 0.0 1.7 2 0 0 2 2 2 1 ATP adenylyltransferase NB-ARC PF00931.17 EFE42248.1 - 8.1e-10 38.0 0.0 1.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 EFE42248.1 - 0.00015 21.8 0.0 0.00053 20.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFE42248.1 - 0.00068 19.6 0.0 0.002 18.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 EFE42248.1 - 0.002 17.8 0.0 0.0044 16.7 0.0 1.5 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 EFE42248.1 - 0.0066 16.3 0.0 0.49 10.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain KaiC PF06745.8 EFE42248.1 - 0.01 15.0 0.0 0.029 13.5 0.0 1.7 1 0 0 1 1 1 1 KaiC GST_N_3 PF13417.1 EFE42249.1 - 1.2e-17 63.9 0.0 1.9e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFE42249.1 - 1.2e-15 57.4 0.0 2.2e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE42249.1 - 8e-12 44.9 0.0 1.2e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Asp PF00026.18 EFE42250.1 - 2.1e-64 217.7 7.1 2.6e-64 217.4 4.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 EFE42250.1 - 0.00024 21.5 0.8 0.24 11.9 0.2 2.8 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.1 EFE42250.1 - 0.00026 20.9 0.2 0.00094 19.1 0.1 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EFE42250.1 - 0.001 18.6 0.0 0.0026 17.3 0.0 1.8 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal AvrPphF-ORF-2 PF09143.5 EFE42250.1 - 0.061 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 AvrPphF-ORF-2 BAR PF03114.13 EFE42251.1 - 1.8e-63 214.1 7.5 2.2e-63 213.8 5.2 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.23 EFE42251.1 - 6.7e-13 47.8 0.0 1.3e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE42251.1 - 4e-12 45.5 0.0 6.9e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFE42251.1 - 7.3e-08 31.7 0.0 1.8e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.5 EFE42251.1 - 0.056 12.6 7.4 0.48 9.6 0.0 2.2 2 0 0 2 2 2 0 Vps5 C terminal like TMPIT PF07851.8 EFE42251.1 - 2.5 7.0 6.2 0.54 9.2 0.9 2.0 1 1 1 2 2 2 0 TMPIT-like protein APG6 PF04111.7 EFE42251.1 - 7.2 5.5 12.8 11 4.9 0.1 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 AlaDh_PNT_N PF05222.10 EFE42252.1 - 3e-20 72.6 0.0 5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 EFE42252.1 - 1.3e-07 31.3 0.0 2.3e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Plant_all_beta PF10532.4 EFE42253.1 - 0.043 13.8 0.0 0.15 12.0 0.0 1.9 1 0 0 1 1 1 0 Plant specific N-all beta domain Palm_thioest PF02089.10 EFE42254.1 - 5.5e-66 222.3 0.0 7.3e-66 221.9 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.2 EFE42254.1 - 0.0001 22.2 0.0 0.00013 21.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE42254.1 - 0.0027 17.4 0.0 0.0035 17.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE42254.1 - 0.0028 17.2 0.0 0.009 15.5 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.6 EFE42254.1 - 0.0094 15.0 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Acetyltransf_1 PF00583.19 EFE42255.1 - 5.2e-10 39.2 0.0 9e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE42255.1 - 8.2e-08 32.2 0.0 1.4e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE42255.1 - 0.00031 20.8 0.0 0.00055 20.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE42255.1 - 0.0076 15.9 0.0 0.028 14.1 0.0 1.9 1 1 1 2 2 2 1 FR47-like protein MOZ_SAS PF01853.13 EFE42255.1 - 0.078 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 MOZ/SAS family Acetyltransf_CG PF14542.1 EFE42255.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF1688 PF07958.6 EFE42256.1 - 0.13 10.7 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) DUF3328 PF11807.3 EFE42257.1 - 2.2e-29 102.7 0.9 8.8e-27 94.1 0.7 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) LPAM_1 PF08139.7 EFE42257.1 - 0.11 12.7 0.8 0.23 11.7 0.5 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Macoilin PF09726.4 EFE42257.1 - 0.42 8.8 6.7 0.59 8.3 4.6 1.1 1 0 0 1 1 1 0 Transmembrane protein Period_C PF12114.3 EFE42257.1 - 4.6 6.7 9.7 8.6 5.9 6.7 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region KTI12 PF08433.5 EFE42258.1 - 3.1e-24 85.6 0.0 2.1e-23 82.8 0.0 2.0 1 1 0 1 1 1 1 Chromatin associated protein KTI12 zf-C2H2 PF00096.21 EFE42259.1 - 0.47 10.9 6.4 3.4 8.1 0.1 3.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type Peptidase_S10 PF00450.17 EFE42260.1 - 8.3e-94 315.0 0.3 1e-93 314.7 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 EFE42260.1 - 0.03 14.1 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Methyltransf_16 PF10294.4 EFE42261.1 - 4.4e-14 52.3 0.0 6.1e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 EFE42261.1 - 0.00083 19.1 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.10 EFE42261.1 - 0.0051 15.9 0.0 0.008 15.3 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G NNMT_PNMT_TEMT PF01234.12 EFE42261.1 - 0.066 12.1 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Antimicrobial_1 PF08018.6 EFE42261.1 - 0.12 12.2 0.7 0.53 10.2 0.2 2.1 2 0 0 2 2 2 0 Frog antimicrobial peptide PrmA PF06325.8 EFE42261.1 - 0.16 11.0 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Macoilin PF09726.4 EFE42262.1 - 1.2 7.3 13.8 1.2 7.3 9.6 1.1 1 0 0 1 1 1 0 Transmembrane protein FAM60A PF15396.1 EFE42262.1 - 3.5 7.3 7.2 4.1 7.0 5.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Hid1 PF12722.2 EFE42262.1 - 4.7 4.7 12.6 5.6 4.5 8.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MFS_1 PF07690.11 EFE42263.1 - 5e-29 101.1 33.0 3.3e-26 91.8 15.4 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily F-box PF00646.28 EFE42264.1 - 0.0026 17.3 0.0 0.0058 16.2 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE42264.1 - 0.051 13.3 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 F-box-like NARP1 PF12569.3 EFE42266.1 - 0.17 10.5 10.5 0.18 10.4 7.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RR_TM4-6 PF06459.7 EFE42266.1 - 0.25 11.1 3.8 0.26 11.1 2.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2011 PF09428.5 EFE42266.1 - 0.49 10.2 21.1 0.59 10.0 14.6 1.1 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) U79_P34 PF03064.11 EFE42266.1 - 0.92 8.9 10.3 0.98 8.8 7.1 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Peptidase_S49_N PF08496.5 EFE42266.1 - 1.1 9.0 6.9 1.2 8.8 4.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RNase_H2-Ydr279 PF09468.5 EFE42266.1 - 1.3 8.1 7.8 1.5 7.9 5.4 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF4337 PF14235.1 EFE42266.1 - 2.7 7.7 7.0 3.4 7.4 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF3987 PF13148.1 EFE42266.1 - 3.6 6.0 8.8 4 5.8 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) YqfQ PF14181.1 EFE42266.1 - 6.5 6.7 8.1 7.6 6.5 5.6 1.1 1 0 0 1 1 1 0 YqfQ-like protein Fungal_trans_2 PF11951.3 EFE42267.1 - 2.2e-89 299.7 0.5 2.8e-89 299.4 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE42267.1 - 1.2e-06 28.3 8.8 2.4e-06 27.3 6.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.27 EFE42268.1 - 3.1e-27 93.4 12.6 2.6e-08 33.4 0.6 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat UAF_Rrn10 PF05234.6 EFE42269.1 - 7.5e-05 22.7 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Mnd1 PF03962.10 EFE42270.1 - 6.7e-44 149.8 5.5 8.6e-44 149.4 3.8 1.1 1 0 0 1 1 1 1 Mnd1 family IncA PF04156.9 EFE42270.1 - 0.0034 17.0 4.1 0.0045 16.6 2.9 1.4 1 0 0 1 1 1 1 IncA protein HTH_20 PF12840.2 EFE42270.1 - 0.0077 16.0 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain RNA_pol_Rpc82 PF05645.8 EFE42270.1 - 0.0083 15.6 1.6 0.47 9.9 0.6 2.1 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 SpoVR PF04293.8 EFE42270.1 - 0.025 12.9 3.4 0.036 12.4 2.4 1.1 1 0 0 1 1 1 0 SpoVR like protein Snapin_Pallidin PF14712.1 EFE42270.1 - 0.085 13.1 2.9 1.7 9.0 1.4 2.6 1 1 1 3 3 3 0 Snapin/Pallidin DUF1465 PF07323.7 EFE42270.1 - 0.094 12.2 1.4 0.34 10.4 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) TBPIP PF07106.8 EFE42270.1 - 0.16 11.5 5.6 0.49 9.9 3.3 2.3 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1515 PF07439.6 EFE42270.1 - 0.27 11.0 1.9 0.45 10.3 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Fib_alpha PF08702.5 EFE42270.1 - 0.35 10.9 8.8 0.57 10.3 4.6 2.3 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Macoilin PF09726.4 EFE42270.1 - 0.52 8.5 6.5 0.56 8.4 4.5 1.1 1 0 0 1 1 1 0 Transmembrane protein CCDC-167 PF15188.1 EFE42270.1 - 0.58 10.1 6.4 3.3 7.7 0.0 2.8 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 DivIC PF04977.10 EFE42270.1 - 0.67 9.4 14.1 0.38 10.2 0.8 3.4 2 1 2 4 4 4 0 Septum formation initiator SlyX PF04102.7 EFE42270.1 - 1.3 9.4 6.2 1.4 9.2 1.1 2.8 2 1 0 2 2 2 0 SlyX DUF904 PF06005.7 EFE42270.1 - 1.9 8.8 9.9 52 4.2 6.9 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Spc24 PF08286.6 EFE42270.1 - 7.4 6.3 9.6 14 5.3 1.0 2.8 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 DHO_dh PF01180.16 EFE42271.1 - 8.2e-63 212.1 0.4 5.8e-55 186.3 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase PcrB PF01884.12 EFE42271.1 - 0.00036 19.8 0.3 0.32 10.2 0.0 2.4 2 0 0 2 2 2 2 PcrB family FMN_dh PF01070.13 EFE42271.1 - 0.0017 17.3 0.4 0.0052 15.6 0.3 1.8 1 1 0 1 1 1 1 FMN-dependent dehydrogenase LacAB_rpiB PF02502.13 EFE42272.1 - 1.2e-41 141.6 0.2 1.4e-41 141.4 0.1 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase DUF2620 PF10941.3 EFE42272.1 - 0.05 13.6 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF2620 TIM PF00121.13 EFE42273.1 - 2.9e-46 157.4 0.0 4.4e-45 153.6 0.0 2.0 1 1 0 1 1 1 1 Triosephosphate isomerase U-box PF04564.10 EFE42276.1 - 3.4e-23 81.3 0.1 7.6e-23 80.2 0.1 1.6 1 0 0 1 1 1 1 U-box domain TPR_11 PF13414.1 EFE42276.1 - 9.1e-10 38.0 8.5 3.3e-09 36.2 0.9 3.2 1 1 1 2 2 2 1 TPR repeat TPR_2 PF07719.12 EFE42276.1 - 1.6e-05 24.4 9.4 0.08 12.9 2.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE42276.1 - 2.3e-05 24.9 2.6 0.19 12.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFE42276.1 - 0.00032 20.5 3.3 0.032 14.1 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-Nse PF11789.3 EFE42276.1 - 0.0011 18.4 0.1 0.0035 16.8 0.0 1.8 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TPR_1 PF00515.23 EFE42276.1 - 0.0086 15.6 6.8 0.072 12.7 2.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFE42276.1 - 0.057 13.7 1.5 2.1 8.7 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE42276.1 - 0.062 13.9 1.5 3.7 8.4 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFE42276.1 - 0.15 12.6 1.7 2.1 8.9 0.8 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 EFE42276.1 - 0.32 11.2 3.3 3.9 7.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ACBP PF00887.14 EFE42277.1 - 9.2e-23 79.7 0.2 1.1e-22 79.5 0.1 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein Tyr-DNA_phospho PF06087.7 EFE42278.1 - 1.3e-146 488.7 0.0 1.6e-146 488.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 EFE42278.1 - 0.00063 19.4 0.0 0.12 12.0 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain AA_permease_2 PF13520.1 EFE42279.1 - 2.3e-32 112.0 23.3 2.3e-32 112.0 16.2 1.3 1 1 1 2 2 2 1 Amino acid permease ABC_membrane PF00664.18 EFE42280.1 - 2.8e-55 187.6 35.0 1.3e-32 113.3 13.3 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.22 EFE42280.1 - 9.8e-48 161.9 0.3 3.6e-27 95.3 0.1 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFE42280.1 - 2.8e-09 37.3 1.0 0.0036 17.3 0.0 4.1 2 2 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFE42280.1 - 5.4e-06 26.3 0.1 0.057 13.3 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 EFE42280.1 - 7.9e-06 26.3 0.6 0.21 12.0 0.0 3.1 2 0 0 2 2 2 2 Miro-like protein SMC_N PF02463.14 EFE42280.1 - 2.1e-05 23.8 6.2 0.75 8.9 0.1 4.0 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EFE42280.1 - 2.2e-05 25.2 0.0 0.34 11.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFE42280.1 - 0.00011 21.6 1.3 0.16 11.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE42280.1 - 0.00019 21.4 4.8 0.062 13.2 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 EFE42280.1 - 0.0006 19.0 1.1 0.22 10.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 ArgK PF03308.11 EFE42280.1 - 0.00094 18.0 1.8 0.33 9.7 0.1 2.4 2 0 0 2 2 2 2 ArgK protein Zeta_toxin PF06414.7 EFE42280.1 - 0.0022 17.1 0.1 2 7.4 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin Dynamin_N PF00350.18 EFE42280.1 - 0.0028 17.4 1.9 0.23 11.2 0.1 2.5 2 0 0 2 2 2 1 Dynamin family AAA_10 PF12846.2 EFE42280.1 - 0.0044 16.5 1.1 1.7 7.9 0.2 2.9 3 0 0 3 3 3 1 AAA-like domain AAA_18 PF13238.1 EFE42280.1 - 0.005 17.1 0.0 5.1 7.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFE42280.1 - 0.011 15.0 0.4 1.6 8.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EFE42280.1 - 0.014 15.7 6.8 0.38 11.0 0.2 3.1 3 0 0 3 3 2 0 AAA domain DUF87 PF01935.12 EFE42280.1 - 0.014 15.2 2.6 0.12 12.2 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_22 PF13401.1 EFE42280.1 - 0.019 15.1 1.1 5.7 7.0 0.0 3.4 3 0 0 3 3 3 0 AAA domain IncA PF04156.9 EFE42280.1 - 0.034 13.7 0.2 0.034 13.7 0.2 3.6 3 1 0 3 3 2 0 IncA protein AAA_15 PF13175.1 EFE42280.1 - 0.047 12.7 0.1 7 5.5 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.1 EFE42280.1 - 0.051 13.5 1.5 0.29 11.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 EFE42280.1 - 0.11 12.0 2.4 2.6 7.5 0.1 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EFE42280.1 - 0.14 12.3 0.2 11 6.2 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Aminotran_3 PF00202.16 EFE42281.1 - 4.2e-103 344.7 0.0 5.2e-103 344.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 EFE42281.1 - 0.01 14.9 0.0 0.022 13.8 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase Glyco_transf_22 PF03901.12 EFE42282.1 - 1.8e-08 33.8 0.0 2e-08 33.6 0.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Glyco_transf_22 PF03901.12 EFE42283.1 - 2.2e-39 135.6 6.3 2.9e-39 135.2 4.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family ArfGap PF01412.13 EFE42284.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf UBA PF00627.26 EFE42284.1 - 0.16 11.8 0.1 0.74 9.7 0.0 2.1 2 0 0 2 2 2 0 UBA/TS-N domain PHD PF00628.24 EFE42285.1 - 1.8e-06 27.5 9.5 4.2e-06 26.3 6.6 1.7 1 0 0 1 1 1 1 PHD-finger SET PF00856.23 EFE42285.1 - 5.2e-06 26.8 0.1 5.2e-06 26.8 0.1 2.7 3 1 0 3 3 3 1 SET domain PHD_2 PF13831.1 EFE42285.1 - 0.27 10.6 5.5 0.51 9.7 3.8 1.5 1 0 0 1 1 1 0 PHD-finger ORC4_C PF14629.1 EFE42286.1 - 6.3e-51 172.6 0.0 1e-50 171.9 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 EFE42286.1 - 6.4e-17 62.1 0.1 2.9e-16 60.0 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFE42286.1 - 5.7e-06 26.5 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EFE42286.1 - 0.00018 20.4 0.0 0.00031 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) KAP_NTPase PF07693.9 EFE42286.1 - 0.00054 19.0 0.0 0.001 18.1 0.0 1.4 1 0 0 1 1 1 1 KAP family P-loop domain AAA PF00004.24 EFE42286.1 - 0.00071 19.7 0.0 0.0028 17.8 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 EFE42286.1 - 0.0013 18.4 0.0 0.0055 16.4 0.0 2.0 1 1 0 1 1 1 1 Archaeal ATPase NACHT PF05729.7 EFE42286.1 - 0.0093 15.6 0.2 0.044 13.4 0.1 2.0 1 1 0 1 1 1 1 NACHT domain AAA_29 PF13555.1 EFE42286.1 - 0.036 13.6 0.1 0.094 12.2 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 EFE42286.1 - 0.045 13.4 0.2 0.14 11.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.13 EFE42286.1 - 0.064 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Dicty_REP PF05086.7 EFE42286.1 - 0.1 10.3 10.3 0.17 9.5 7.1 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RNase_PH_C PF03725.10 EFE42288.1 - 0.054 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 zf-BED PF02892.10 EFE42289.1 - 0.021 14.5 0.6 0.042 13.5 0.4 1.5 1 0 0 1 1 1 0 BED zinc finger DNA_pol_B_palm PF14792.1 EFE42290.1 - 1.5e-30 105.5 0.0 3e-30 104.5 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 EFE42290.1 - 2.3e-20 72.0 0.0 4.8e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 EFE42290.1 - 5.6e-19 67.4 0.5 5.6e-19 67.4 0.3 2.4 3 0 0 3 3 3 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 EFE42290.1 - 3.6e-17 62.3 0.7 8e-17 61.1 0.5 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.1 EFE42290.1 - 0.014 15.5 0.1 6.6 6.9 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain NTP_transf_2 PF01909.18 EFE42290.1 - 0.027 14.8 0.1 0.079 13.2 0.0 1.8 1 0 0 1 1 1 0 Nucleotidyltransferase domain ATP-synt_10 PF05176.9 EFE42291.1 - 3.1e-81 272.3 0.0 3.9e-81 272.0 0.0 1.2 1 0 0 1 1 1 1 ATP10 protein V-SNARE_C PF12352.3 EFE42292.1 - 3.6e-16 58.9 7.0 2e-15 56.5 0.1 2.9 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 EFE42292.1 - 0.014 15.1 0.9 3.4 7.4 0.0 2.6 2 1 1 3 3 3 0 Sec20 AAA_13 PF13166.1 EFE42292.1 - 0.043 12.2 1.2 0.053 11.9 0.8 1.1 1 0 0 1 1 1 0 AAA domain TBPIP PF07106.8 EFE42292.1 - 0.073 12.6 2.7 0.11 11.9 1.8 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Het-C PF07217.6 EFE42292.1 - 0.081 11.1 0.2 1.7 6.7 0.0 1.9 1 1 1 2 2 2 0 Heterokaryon incompatibility protein Het-C PA28_beta PF02252.13 EFE42292.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit DivIC PF04977.10 EFE42292.1 - 0.16 11.4 4.8 2.6 7.5 0.6 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF4570 PF15134.1 EFE42292.1 - 0.2 11.5 4.0 0.34 10.7 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Spc7 PF08317.6 EFE42292.1 - 0.8 8.3 5.1 1.4 7.5 3.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Ribosomal_L29 PF00831.18 EFE42293.1 - 3.2e-18 65.1 0.4 3.2e-18 65.1 0.2 2.0 2 1 0 2 2 2 1 Ribosomal L29 protein GSH_synthase PF03199.10 EFE42293.1 - 0.08 13.0 0.4 0.14 12.2 0.3 1.5 1 1 0 1 1 1 0 Eukaryotic glutathione synthase Cortex-I_coil PF09304.5 EFE42293.1 - 0.14 12.2 7.7 0.13 12.3 1.2 2.2 1 1 0 2 2 2 0 Cortexillin I, coiled coil Phe_tRNA-synt_N PF02912.13 EFE42293.1 - 0.46 10.2 0.1 0.46 10.2 0.1 2.5 3 0 0 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain FliT PF05400.8 EFE42293.1 - 1.9 8.9 5.2 3.1 8.2 0.1 2.4 2 1 0 2 2 2 0 Flagellar protein FliT Med16 PF11635.3 EFE42294.1 - 4e-138 461.5 0.0 3e-136 455.3 0.0 2.0 1 1 1 2 2 2 2 Mediator complex subunit 16 SIR2 PF02146.12 EFE42295.1 - 3.5e-26 91.9 0.0 1.3e-25 90.1 0.0 1.9 1 1 0 1 1 1 1 Sir2 family FAD_binding_4 PF01565.18 EFE42295.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain CBFD_NFYB_HMF PF00808.18 EFE42296.1 - 6.2e-06 26.1 0.0 9.6e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone BUD22 PF09073.5 EFE42296.1 - 0.75 8.7 20.4 0.95 8.4 14.2 1.1 1 0 0 1 1 1 0 BUD22 GN3L_Grn1 PF08701.6 EFE42297.1 - 5.2e-25 87.1 16.7 5.2e-25 87.1 11.6 2.6 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 EFE42297.1 - 7.7e-22 77.4 0.2 4.6e-15 55.5 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE42297.1 - 1.1e-05 24.7 0.1 8.3e-05 21.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 EFE42297.1 - 8.6e-05 22.0 0.1 0.25 10.7 0.0 3.1 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EFE42297.1 - 0.00012 21.3 0.1 0.00021 20.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EFE42297.1 - 0.00022 21.1 11.0 0.76 9.5 0.1 4.2 2 2 1 3 3 3 2 Dynamin family Miro PF08477.8 EFE42297.1 - 0.0006 20.2 0.2 1.7 9.1 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein cobW PF02492.14 EFE42297.1 - 0.017 14.5 1.4 1.3 8.4 0.0 3.5 3 1 1 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 EFE42297.1 - 0.044 12.5 0.1 0.044 12.5 0.1 1.6 2 0 0 2 2 2 0 ArgK protein AIG1 PF04548.11 EFE42297.1 - 0.055 12.5 0.1 0.055 12.5 0.1 2.4 3 0 0 3 3 3 0 AIG1 family AAA_18 PF13238.1 EFE42297.1 - 0.065 13.5 0.0 0.065 13.5 0.0 2.9 3 1 0 3 3 3 0 AAA domain MobB PF03205.9 EFE42297.1 - 0.074 12.7 1.0 0.28 10.8 0.1 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 EFE42297.1 - 0.21 11.5 3.2 0.9 9.4 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain HAD_2 PF13419.1 EFE42298.1 - 2.5e-12 47.3 0.0 3.3e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE42298.1 - 1.8e-08 33.9 0.1 4.7e-08 32.6 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 EFE42298.1 - 3.6e-07 30.8 0.0 1.1e-06 29.2 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 EFE42298.1 - 0.049 13.5 0.0 0.73 9.7 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Homeobox PF00046.24 EFE42299.1 - 1.8e-16 59.4 1.5 1.6e-15 56.4 1.9 1.9 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 EFE42299.1 - 0.0001 21.9 0.5 0.00028 20.5 0.3 1.8 1 0 0 1 1 1 1 Homeobox KN domain BTB PF00651.26 EFE42300.1 - 1.3e-05 25.1 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Chordopox_E11 PF06138.7 EFE42300.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 Chordopoxvirus E11 protein RabGAP-TBC PF00566.13 EFE42301.1 - 1.8e-34 119.1 0.0 3e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TPP_enzyme_N PF02776.13 EFE42302.1 - 7.8e-43 145.9 0.0 1.4e-42 145.0 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EFE42302.1 - 1.5e-18 66.8 0.0 3.3e-17 62.4 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EFE42302.1 - 6.7e-16 58.2 0.0 1.4e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain DXP_synthase_N PF13292.1 EFE42302.1 - 0.15 10.9 0.0 0.61 8.9 0.0 1.8 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase Mo25 PF08569.6 EFE42303.1 - 1.4e-103 346.4 0.0 9.1e-101 337.2 0.0 2.3 1 1 1 2 2 2 2 Mo25-like Methyltransf_31 PF13847.1 EFE42304.1 - 3e-11 43.1 0.0 5.7e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFE42304.1 - 8.3e-09 34.9 0.0 1.4e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 EFE42304.1 - 2.6e-08 34.4 0.1 8.6e-08 32.7 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE42304.1 - 2.8e-08 34.1 0.0 5.6e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE42304.1 - 7e-07 29.2 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE42304.1 - 4.6e-06 26.1 0.1 8.1e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 EFE42304.1 - 1.9e-05 24.4 0.0 3.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE42304.1 - 0.00016 21.9 0.0 0.00046 20.5 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EFE42304.1 - 0.00028 19.6 0.0 0.00042 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PRMT5 PF05185.11 EFE42304.1 - 0.0035 16.3 0.0 0.0056 15.6 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.7 EFE42304.1 - 0.0056 17.1 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EFE42304.1 - 0.02 14.4 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 EFE42304.1 - 0.041 13.0 0.0 0.068 12.3 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB FtsJ PF01728.14 EFE42304.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase CMAS PF02353.15 EFE42304.1 - 0.047 12.7 0.0 0.18 10.8 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Met_10 PF02475.11 EFE42304.1 - 0.061 12.8 0.1 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_24 PF13578.1 EFE42304.1 - 0.09 13.6 0.0 0.26 12.1 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain Cir_N PF10197.4 EFE42305.1 - 0.0017 18.2 7.4 0.0017 18.2 5.1 4.2 4 1 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR AAA PF00004.24 EFE42306.1 - 9e-54 181.2 0.0 1.2e-38 132.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.12 EFE42306.1 - 8.4e-11 41.3 0.1 2.2e-09 36.7 0.0 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.1 EFE42306.1 - 1e-09 38.6 0.3 0.00081 19.5 0.0 4.0 2 2 1 3 3 3 2 AAA domain AAA_14 PF13173.1 EFE42306.1 - 2.1e-09 37.3 0.0 0.0047 16.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain CDC48_N PF02359.13 EFE42306.1 - 2.9e-09 36.7 0.0 7.9e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_17 PF13207.1 EFE42306.1 - 3.5e-09 37.5 0.1 0.0034 18.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFE42306.1 - 7.4e-09 35.8 0.1 0.0018 18.3 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_19 PF13245.1 EFE42306.1 - 1e-08 34.7 1.9 0.0041 16.8 0.0 3.4 3 0 0 3 3 3 2 Part of AAA domain AAA_5 PF07728.9 EFE42306.1 - 1.8e-08 34.1 0.0 0.0011 18.6 0.0 2.8 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 EFE42306.1 - 6.2e-08 33.0 0.0 0.0051 17.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain TIP49 PF06068.8 EFE42306.1 - 6.8e-08 31.6 0.0 0.0059 15.3 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus RuvB_N PF05496.7 EFE42306.1 - 8.2e-08 31.5 0.0 0.0072 15.4 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 EFE42306.1 - 1.9e-07 31.1 0.0 5.2e-05 23.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.16 EFE42306.1 - 2e-07 30.3 0.1 0.004 16.3 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 EFE42306.1 - 3.1e-07 30.3 0.0 0.01 15.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EFE42306.1 - 6.4e-07 29.5 0.0 0.05 13.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.12 EFE42306.1 - 2.2e-06 27.2 0.1 0.034 13.5 0.0 2.7 3 0 0 3 3 3 2 IstB-like ATP binding protein Zeta_toxin PF06414.7 EFE42306.1 - 1e-05 24.7 0.0 0.077 12.0 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_24 PF13479.1 EFE42306.1 - 1.1e-05 25.0 0.4 0.1 12.1 0.1 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EFE42306.1 - 2.5e-05 23.9 0.8 0.027 14.1 0.0 3.1 3 1 0 3 3 2 1 NACHT domain AAA_25 PF13481.1 EFE42306.1 - 3.3e-05 23.3 2.0 0.4 10.0 0.0 3.5 2 2 2 4 4 4 2 AAA domain KaiC PF06745.8 EFE42306.1 - 4.8e-05 22.5 0.3 0.016 14.3 0.1 2.6 2 0 0 2 2 2 1 KaiC AAA_28 PF13521.1 EFE42306.1 - 5.4e-05 23.2 0.0 0.42 10.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.17 EFE42306.1 - 9e-05 21.4 0.2 0.2 10.4 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain PhoH PF02562.11 EFE42306.1 - 0.0002 20.6 0.2 0.63 9.2 0.0 2.8 3 0 0 3 3 3 2 PhoH-like protein ABC_tran PF00005.22 EFE42306.1 - 0.00023 21.4 0.3 0.039 14.2 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_3 PF07726.6 EFE42306.1 - 0.00026 20.5 0.0 0.36 10.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFE42306.1 - 0.00058 19.3 0.0 0.5 9.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF2075 PF09848.4 EFE42306.1 - 0.0011 18.0 0.0 0.4 9.5 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 EFE42306.1 - 0.0011 18.5 0.0 1.4 8.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 EFE42306.1 - 0.0013 18.4 0.4 3.3 7.3 0.2 3.4 2 1 1 3 3 3 0 Archaeal ATPase KTI12 PF08433.5 EFE42306.1 - 0.0019 17.4 0.1 0.51 9.4 0.0 2.8 3 0 0 3 3 2 1 Chromatin associated protein KTI12 UPF0079 PF02367.12 EFE42306.1 - 0.0022 17.5 0.1 1 9.0 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Parvo_NS1 PF01057.12 EFE42306.1 - 0.003 16.4 0.0 0.35 9.7 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_30 PF13604.1 EFE42306.1 - 0.0069 15.9 0.0 1 8.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 EFE42306.1 - 0.0097 15.9 0.1 8 6.5 0.0 3.1 3 1 0 3 3 2 0 Sigma-54 interaction domain DEAD PF00270.24 EFE42306.1 - 0.012 15.0 0.4 15 5.0 0.0 4.1 2 2 1 3 3 3 0 DEAD/DEAH box helicase ResIII PF04851.10 EFE42306.1 - 0.022 14.6 0.3 9.7 5.9 0.0 3.0 3 1 0 3 3 2 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.10 EFE42306.1 - 0.024 14.3 0.1 11 5.6 0.0 3.1 3 0 0 3 3 2 0 NTPase SRP54 PF00448.17 EFE42306.1 - 0.039 13.3 0.2 4.2 6.7 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain T2SE PF00437.15 EFE42306.1 - 0.049 12.5 0.0 5.4 5.8 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.14 EFE42306.1 - 0.063 12.7 0.2 3.8 6.9 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IPT PF01745.11 EFE42306.1 - 0.08 12.1 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase KAP_NTPase PF07693.9 EFE42306.1 - 0.085 11.8 0.0 7.3 5.4 0.0 3.0 3 0 0 3 3 3 0 KAP family P-loop domain AAA_29 PF13555.1 EFE42306.1 - 0.12 11.9 0.1 5.8 6.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain KxDL PF10241.4 EFE42308.1 - 3.4e-22 78.1 1.2 4.2e-18 65.0 0.2 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein HATPase_c PF02518.21 EFE42310.1 - 3.3e-21 75.0 0.6 6.6e-21 74.1 0.1 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EFE42310.1 - 1.7e-16 59.9 0.0 5.9e-16 58.2 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.19 EFE42310.1 - 3e-16 59.4 0.0 6.3e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain PAS_3 PF08447.6 EFE42310.1 - 3.8e-11 42.9 1.3 0.0018 18.3 0.1 3.8 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.1 EFE42310.1 - 1e-09 38.7 0.0 3.5e-06 27.3 0.0 3.9 3 1 0 3 3 3 1 PAS domain PAS_4 PF08448.5 EFE42310.1 - 8.6e-06 25.7 0.1 3.4e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS PF00989.19 EFE42310.1 - 0.00021 21.0 0.0 0.24 11.2 0.0 3.5 3 0 0 3 3 3 2 PAS fold HATPase_c_2 PF13581.1 EFE42310.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain OmpH PF03938.9 EFE42310.1 - 0.46 10.4 11.7 1.4 8.7 5.0 2.9 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) HATPase_c PF02518.21 EFE42312.1 - 1.7e-29 101.7 0.0 8.2e-29 99.5 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EFE42312.1 - 2.5e-20 72.2 0.0 8.7e-20 70.4 0.0 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.19 EFE42312.1 - 5.4e-20 71.4 0.2 1.7e-19 69.8 0.1 2.0 2 0 0 2 2 1 1 Response regulator receiver domain AAA_16 PF13191.1 EFE42312.1 - 2.2e-11 44.1 0.2 2.5e-10 40.6 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain GAF_2 PF13185.1 EFE42312.1 - 5.9e-11 43.0 0.0 1.6e-10 41.6 0.0 1.8 1 0 0 1 1 1 1 GAF domain GAF PF01590.21 EFE42312.1 - 2e-08 34.5 0.0 5.6e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.20 EFE42312.1 - 3.1e-07 29.8 0.0 1.5e-06 27.6 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain GAF_3 PF13492.1 EFE42312.1 - 9.6e-07 28.9 0.0 3.4e-06 27.1 0.0 2.0 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.1 EFE42312.1 - 1e-05 25.2 0.0 2.2e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_22 PF13401.1 EFE42312.1 - 0.00083 19.4 0.0 0.13 12.3 0.0 3.3 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EFE42312.1 - 0.0038 16.0 0.0 0.0076 15.0 0.0 1.4 1 0 0 1 1 1 1 ArgK protein NB-ARC PF00931.17 EFE42312.1 - 0.0044 15.9 0.0 0.13 11.1 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain AAA_35 PF14516.1 EFE42312.1 - 0.021 13.4 0.0 0.28 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain TPR_2 PF07719.12 EFE42312.1 - 0.052 13.4 3.2 5.7 7.1 0.1 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFE42312.1 - 0.065 12.8 1.3 0.36 10.5 0.1 2.7 2 0 0 2 2 2 0 TPR repeat Tom5 PF10642.4 EFE42312.1 - 0.34 10.5 5.1 1 9.0 0.5 3.3 3 0 0 3 3 3 0 Mitochondrial import receptor subunit or translocase Allantoicase PF03561.10 EFE42313.1 - 5.3e-91 301.9 0.0 1.2e-48 164.4 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat Cytochrom_B561 PF03188.11 EFE42314.1 - 6.7e-16 58.3 2.1 6.7e-16 58.3 1.4 1.4 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4271 PF14093.1 EFE42314.1 - 0.0069 16.0 5.1 0.0098 15.5 3.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4271) Cytochrom_B_N PF00033.14 EFE42314.1 - 0.019 14.3 4.9 0.1 11.9 3.2 2.1 1 1 1 2 2 2 0 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.15 EFE42314.1 - 0.071 12.4 6.4 0.59 9.5 4.4 2.3 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 PepSY_TM_1 PF13172.1 EFE42314.1 - 0.21 11.3 2.9 0.59 9.9 0.1 2.7 2 0 0 2 2 2 0 PepSY-associated TM helix DUF2306 PF10067.4 EFE42314.1 - 0.42 10.7 9.3 0.16 12.1 0.4 2.8 2 1 1 3 3 3 0 Predicted membrane protein (DUF2306) DUF2427 PF10348.4 EFE42314.1 - 0.65 9.5 4.2 1.7 8.2 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) DUF1129 PF06570.6 EFE42314.1 - 1 8.6 4.3 2 7.7 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) Tic20 PF09685.5 EFE42314.1 - 5.2 7.1 13.6 0.085 12.8 4.3 1.9 2 1 0 2 2 2 0 Tic20-like protein PepSY_TM_2 PF13703.1 EFE42314.1 - 7.3 6.8 8.3 12 6.1 0.0 3.4 3 1 1 4 4 4 0 PepSY-associated TM helix tRNA-synt_2b PF00587.20 EFE42315.1 - 3.1e-22 78.9 0.0 4.8e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EFE42315.1 - 7.5e-09 35.5 2.3 1.4e-08 34.7 1.6 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF342 PF03961.8 EFE42315.1 - 0.0005 18.6 3.7 0.00072 18.0 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF342) tRNA-synt_His PF13393.1 EFE42315.1 - 0.027 13.5 1.0 2.4 7.1 0.7 2.2 2 0 0 2 2 2 0 Histidyl-tRNA synthetase DUF3972 PF13118.1 EFE42315.1 - 0.034 14.2 0.2 0.065 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) Spc7 PF08317.6 EFE42315.1 - 0.05 12.2 1.3 0.077 11.6 0.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2205 PF10224.4 EFE42315.1 - 0.059 12.9 4.8 0.58 9.7 0.1 2.5 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) Flagellar_rod PF05149.7 EFE42315.1 - 0.062 12.4 1.7 0.091 11.9 1.2 1.2 1 0 0 1 1 1 0 Paraflagellar rod protein TMF_DNA_bd PF12329.3 EFE42315.1 - 0.28 11.0 7.3 1.8 8.4 3.1 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF904 PF06005.7 EFE42315.1 - 0.65 10.3 5.0 0.63 10.3 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF904) DivIC PF04977.10 EFE42315.1 - 0.65 9.5 6.5 3.5 7.1 0.2 2.3 1 1 1 2 2 2 0 Septum formation initiator Mnd1 PF03962.10 EFE42315.1 - 1 8.9 6.2 0.34 10.5 2.3 1.6 2 0 0 2 2 2 0 Mnd1 family DUF1679 PF07914.6 EFE42316.1 - 0.0014 17.3 0.0 0.003 16.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.18 EFE42316.1 - 0.0021 17.8 0.0 0.0043 16.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 EFE42317.1 - 0.00018 20.7 1.3 0.005 16.0 0.9 2.1 1 1 0 1 1 1 1 Protein kinase domain ABC_membrane PF00664.18 EFE42318.1 - 2.3e-77 260.0 43.8 1.5e-40 139.4 10.6 2.6 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE42318.1 - 1.6e-68 229.2 0.1 3.9e-33 114.6 0.0 3.2 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 EFE42318.1 - 3.1e-15 56.9 0.0 0.0018 18.3 0.0 4.5 3 1 0 4 4 4 4 AAA domain SMC_N PF02463.14 EFE42318.1 - 3.7e-13 49.2 4.7 0.00068 18.9 0.0 4.4 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EFE42318.1 - 1e-09 38.6 1.0 0.00011 22.3 0.0 3.1 2 1 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.1 EFE42318.1 - 1.1e-09 37.6 0.3 0.00027 20.3 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 EFE42318.1 - 1.4e-09 37.3 0.0 0.00021 20.5 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 ABC_ATPase PF09818.4 EFE42318.1 - 3.1e-08 32.6 1.9 0.0065 15.1 0.0 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_17 PF13207.1 EFE42318.1 - 4.9e-08 33.8 0.3 0.0038 18.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.1 EFE42318.1 - 7.2e-07 29.4 2.4 0.12 12.5 0.1 4.3 2 2 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFE42318.1 - 2.7e-06 26.9 0.1 0.093 12.1 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA PF00004.24 EFE42318.1 - 1e-05 25.7 2.1 0.02 15.1 0.1 4.1 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFE42318.1 - 2.3e-05 24.1 0.0 0.022 14.4 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 EFE42318.1 - 0.00013 21.9 0.0 0.16 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFE42318.1 - 0.00021 21.2 0.0 0.073 13.0 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SbcCD_C PF13558.1 EFE42318.1 - 0.00028 20.7 2.2 1.4 8.9 0.1 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.1 EFE42318.1 - 0.00033 20.6 0.4 1.9 8.4 0.0 3.3 2 1 0 2 2 2 2 AAA domain MobB PF03205.9 EFE42318.1 - 0.00038 20.1 0.0 0.16 11.6 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 EFE42318.1 - 0.00043 20.1 0.0 0.56 10.1 0.0 4.0 4 0 0 4 4 3 1 AAA domain AAA_23 PF13476.1 EFE42318.1 - 0.00069 19.9 1.2 0.95 9.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EFE42318.1 - 0.00075 19.8 0.6 1.5 9.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_10 PF12846.2 EFE42318.1 - 0.0014 18.1 3.2 0.8 9.0 0.0 3.4 3 0 0 3 3 3 1 AAA-like domain RNA_helicase PF00910.17 EFE42318.1 - 0.0035 17.5 0.1 0.2 11.8 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Miro PF08477.8 EFE42318.1 - 0.035 14.6 0.0 3.9 7.9 0.0 2.9 2 0 0 2 2 2 0 Miro-like protein VirC2 PF07181.6 EFE42318.1 - 0.071 12.5 0.5 11 5.3 0.0 2.3 2 0 0 2 2 2 0 VirC2 protein Zeta_toxin PF06414.7 EFE42318.1 - 0.099 11.7 1.2 13 4.8 0.0 3.3 4 0 0 4 4 3 0 Zeta toxin APS_kinase PF01583.15 EFE42318.1 - 0.12 12.0 0.2 2.4 7.8 0.1 2.7 2 1 0 2 2 2 0 Adenylylsulphate kinase G-alpha PF00503.15 EFE42318.1 - 0.13 10.9 0.0 6.8 5.2 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit ATP-synt_ab PF00006.20 EFE42318.1 - 0.14 11.6 1.0 6.3 6.2 0.0 3.3 4 0 0 4 4 4 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF3632 PF12311.3 EFE42319.1 - 5.1e-34 117.6 0.1 7.2e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) AMP-binding PF00501.23 EFE42320.1 - 4.9e-51 173.4 0.2 1.2e-50 172.1 0.1 1.5 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE42320.1 - 0.0078 17.1 0.0 0.025 15.5 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.11 EFE42321.1 - 6.6e-29 100.7 38.2 6.6e-29 100.7 26.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFE42321.1 - 0.025 14.0 2.7 0.069 12.6 1.9 1.8 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 Gln-synt_C PF00120.19 EFE42322.1 - 1.4e-59 201.3 0.0 1.7e-59 201.0 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 EFE42322.1 - 1.1e-17 63.3 0.1 1.5e-15 56.5 0.0 2.3 2 0 0 2 2 2 2 Glutamine synthetase, beta-Grasp domain Med1 PF10744.4 EFE42324.1 - 3.8e-54 183.9 0.0 9.9e-53 179.3 0.0 2.5 2 1 0 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 Vfa1 PF08432.5 EFE42325.1 - 0.0058 16.6 11.6 0.01 15.8 8.0 1.3 1 1 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.12 EFE42325.1 - 0.7 9.6 6.2 0.77 9.5 4.3 1.1 1 0 0 1 1 1 0 DDHD domain DUF159 PF02586.9 EFE42326.1 - 3.5e-57 193.2 0.0 4.8e-57 192.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, COG2135 TPR_12 PF13424.1 EFE42327.1 - 1.9e-08 34.1 11.9 0.003 17.4 0.5 5.0 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFE42327.1 - 3.4e-05 23.4 5.4 0.1 12.5 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFE42327.1 - 4.3e-05 22.9 5.5 0.015 14.9 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE42327.1 - 0.001 18.7 4.2 1.7 8.6 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE42327.1 - 0.0012 18.4 9.5 2.1 8.0 0.0 4.4 5 0 0 5 5 5 3 TPR repeat TPR_7 PF13176.1 EFE42327.1 - 0.049 13.4 9.8 6.9 6.7 0.1 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF4071 PF13281.1 EFE42327.1 - 0.29 9.9 3.0 3.4 6.4 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4071) TPR_6 PF13174.1 EFE42327.1 - 0.75 10.3 15.0 2.4 8.8 0.1 6.3 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFE42327.1 - 1.1 9.9 12.3 6.9 7.4 0.6 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat WD40 PF00400.27 EFE42328.1 - 7.5e-58 190.4 24.2 1e-11 44.2 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 EFE42328.1 - 0.00022 19.4 8.1 0.64 8.0 0.1 4.1 2 1 1 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 EFE42328.1 - 0.0088 14.3 0.0 0.72 8.0 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.7 EFE42328.1 - 0.037 13.7 0.1 44 3.8 0.0 4.3 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Sdh5 PF03937.11 EFE42329.1 - 3e-08 33.2 0.3 6.6e-08 32.1 0.1 1.6 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase EMP24_GP25L PF01105.19 EFE42330.1 - 8.7e-41 139.6 0.0 1.1e-40 139.2 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MAD PF05557.8 EFE42330.1 - 0.11 10.5 0.2 0.14 10.1 0.2 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein CENP-R PF06729.7 EFE42331.1 - 8.9 5.9 10.3 0.14 11.8 1.4 2.3 2 0 0 2 2 2 0 Kinetochore component, CENP-R DUF3328 PF11807.3 EFE42332.1 - 0.012 15.2 2.5 0.92 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) DUF1180 PF06679.7 EFE42332.1 - 0.082 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Spore_coat_CotO PF14153.1 EFE42334.1 - 0.019 14.4 1.1 0.039 13.4 0.8 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Nop14 PF04147.7 EFE42334.1 - 0.16 9.8 27.0 0.19 9.5 18.7 1.3 1 0 0 1 1 1 0 Nop14-like family SpoIIIAH PF12685.2 EFE42334.1 - 0.2 11.1 5.7 0.46 9.9 4.0 1.5 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF1510 PF07423.6 EFE42334.1 - 5.3 6.3 15.0 12 5.1 10.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RNA_pol_I_A49 PF06870.7 EFE42335.1 - 0.022 13.3 0.3 0.026 13.0 0.2 1.1 1 0 0 1 1 1 0 A49-like RNA polymerase I associated factor LysE PF01810.13 EFE42335.1 - 0.079 12.2 0.1 0.16 11.2 0.0 1.5 1 1 1 2 2 2 0 LysE type translocator EphA2_TM PF14575.1 EFE42335.1 - 0.36 11.2 2.5 1.5 9.2 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF1265 PF06887.9 EFE42335.1 - 0.39 10.3 1.6 0.59 9.8 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1265) UPF0542 PF15086.1 EFE42335.1 - 1.8 8.3 6.5 9.5 6.0 1.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 NDUFA12 PF05071.11 EFE42337.1 - 8.1e-09 35.8 3.8 1.9e-08 34.6 2.7 1.8 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF2076 PF09849.4 EFE42337.1 - 0.89 9.5 7.5 1.1 9.2 5.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CH PF00307.26 EFE42338.1 - 9.6e-11 41.6 0.0 1.7e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.6 EFE42338.1 - 0.064 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 CDC24 Calponin CAMSAP_CH PF11971.3 EFE42338.1 - 0.17 11.5 0.0 0.4 10.3 0.0 1.6 1 1 0 1 1 1 0 CAMSAP CH domain DUF3381 PF11861.3 EFE42339.1 - 0.57 9.6 6.2 1.1 8.7 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) PGA2 PF07543.7 EFE42339.1 - 2.1 8.1 7.7 7 6.4 4.0 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 ORMDL PF04061.9 EFE42341.1 - 1.7e-59 199.2 5.0 2.2e-59 198.9 3.5 1.1 1 0 0 1 1 1 1 ORMDL family Trep_Strep PF09605.5 EFE42341.1 - 0.77 9.4 4.7 0.63 9.6 1.0 1.9 1 1 1 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) zf-CCHC_2 PF13696.1 EFE42342.1 - 0.027 13.9 2.9 5.2 6.6 0.1 2.8 2 0 0 2 2 2 0 Zinc knuckle APH PF01636.18 EFE42343.1 - 1.6e-11 44.4 0.0 5.2e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFE42343.1 - 0.0053 15.9 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 EFE42343.1 - 0.012 14.3 0.0 0.02 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Choline_kinase PF01633.15 EFE42343.1 - 0.013 15.0 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Arm PF00514.18 EFE42347.1 - 5.4e-62 203.6 27.7 4.6e-11 42.1 0.1 11.2 11 0 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EFE42347.1 - 6e-22 77.7 7.7 3.4e-07 30.4 0.3 7.1 4 1 3 7 7 7 6 HEAT repeats HEAT PF02985.17 EFE42347.1 - 4.9e-17 60.4 14.1 0.032 14.2 0.0 9.4 10 0 0 10 10 10 5 HEAT repeat HEAT_EZ PF13513.1 EFE42347.1 - 1.3e-11 44.5 16.5 0.071 13.6 0.3 8.1 8 1 0 8 8 8 4 HEAT-like repeat Adaptin_N PF01602.15 EFE42347.1 - 9.4e-08 30.8 8.4 0.00015 20.2 1.7 3.7 1 1 1 2 2 2 2 Adaptin N terminal region V-ATPase_H_N PF03224.9 EFE42347.1 - 0.00021 20.5 1.7 0.0028 16.8 0.2 2.8 2 1 0 3 3 3 1 V-ATPase subunit H KAP PF05804.7 EFE42347.1 - 0.0003 18.8 0.2 0.00051 18.1 0.1 1.5 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) HEAT_PBS PF03130.11 EFE42347.1 - 0.0084 16.4 3.3 1 9.9 0.4 5.0 4 1 0 4 4 4 1 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFE42347.1 - 0.09 13.1 0.0 0.58 10.5 0.1 2.4 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region EXOSC1 PF10447.4 EFE42348.1 - 8.9e-28 96.0 1.8 1.5e-27 95.3 1.2 1.3 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.1 EFE42348.1 - 5.6e-15 54.3 0.1 9.1e-15 53.6 0.1 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region GTP_EFTU PF00009.22 EFE42349.1 - 3e-46 157.2 0.0 6.1e-46 156.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 EFE42349.1 - 8.3e-08 31.9 0.0 2.3e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 EFE42349.1 - 1.9e-07 31.1 0.0 7.3e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_C PF00679.19 EFE42349.1 - 7.6e-07 28.9 0.0 1.9e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.13 EFE42349.1 - 7.3e-06 25.5 0.0 0.00072 19.1 0.0 2.6 2 0 0 2 2 2 1 Elongation factor G, domain IV SET PF00856.23 EFE42349.1 - 0.0071 16.6 0.2 0.039 14.2 0.0 2.2 2 0 0 2 2 2 1 SET domain DUF3391 PF11871.3 EFE42349.1 - 0.041 14.0 0.2 0.15 12.2 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) NAD_kinase PF01513.16 EFE42350.1 - 2e-72 243.3 0.0 2.5e-72 243.0 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase Brevenin PF03032.10 EFE42351.1 - 8.1 6.3 6.9 10 6.0 4.8 1.2 1 0 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family Las1 PF04031.8 EFE42353.1 - 8.4e-17 61.2 0.2 1.4e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 Las1-like Lactamase_B PF00753.22 EFE42354.1 - 3.8e-19 69.0 1.6 5.6e-19 68.5 1.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily BcrAD_BadFG PF01869.15 EFE42354.1 - 0.0099 15.1 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Peptidase_S24 PF00717.18 EFE42355.1 - 5.2e-09 35.6 0.1 8e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like PBP PF01161.15 EFE42356.1 - 2.2e-10 40.5 0.0 3.6e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF4615 PF15393.1 EFE42356.1 - 0.36 11.0 6.1 0.92 9.7 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4615) ABC_tran_2 PF12848.2 EFE42356.1 - 4 7.3 10.2 0.39 10.5 3.5 2.0 2 0 0 2 2 2 0 ABC transporter Ribosomal_L4 PF00573.17 EFE42357.1 - 5.2e-45 153.2 0.0 6.6e-45 152.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family ECH_C PF13766.1 EFE42358.1 - 7e-39 132.6 0.1 1.4e-38 131.6 0.0 1.5 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 EFE42358.1 - 6e-22 77.9 0.0 2.9e-21 75.7 0.0 2.0 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase family RhoGAP PF00620.22 EFE42359.1 - 0.11 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 RhoGAP domain CBS PF00571.23 EFE42360.1 - 1.9e-21 75.5 7.2 1.5e-10 40.6 0.3 3.1 3 0 0 3 3 3 3 CBS domain CRAL_TRIO PF00650.15 EFE42361.1 - 4.5e-36 123.7 0.0 6.2e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFE42361.1 - 1e-11 44.7 0.0 3.8e-11 42.9 0.0 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EFE42361.1 - 2.3e-05 24.3 0.0 3.2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pol_alpha_B_N PF08418.5 EFE42362.1 - 4.8e-19 68.8 0.0 4.8e-19 68.8 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 EFE42363.1 - 1.8e-34 118.8 0.0 2.5e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.5 EFE42363.1 - 5e-24 85.2 0.9 6.8e-24 84.7 0.6 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal Metallophos_3 PF14582.1 EFE42363.1 - 0.092 11.8 0.0 7.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Apc13p PF05839.6 EFE42364.1 - 1.6e-17 63.2 0.1 1.9e-17 63.0 0.1 1.2 1 0 0 1 1 1 1 Apc13p protein IF-2B PF01008.12 EFE42365.1 - 1.7e-64 217.5 0.1 2.3e-64 217.1 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Kinesin PF00225.18 EFE42366.1 - 3.4e-111 371.1 0.0 6.2e-111 370.3 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Bacillus_HBL PF05791.6 EFE42366.1 - 0.0042 16.4 4.5 0.022 14.1 0.0 2.7 2 1 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) DUF1460 PF07313.7 EFE42366.1 - 0.018 14.2 1.5 0.035 13.3 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1460) DUF2422 PF10337.4 EFE42366.1 - 0.16 10.7 3.0 0.88 8.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2422) Mnd1 PF03962.10 EFE42366.1 - 1.4 8.5 11.2 4.2 6.9 7.8 1.8 1 0 0 1 1 1 0 Mnd1 family DUF87 PF01935.12 EFE42366.1 - 1.7 8.4 9.8 0.75 9.5 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF87 DUF972 PF06156.8 EFE42366.1 - 2.3 8.5 10.9 8.3 6.8 3.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF972) V_ATPase_I PF01496.14 EFE42366.1 - 3.8 5.2 8.3 6.1 4.5 5.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PUL PF08324.6 EFE42367.1 - 2.3e-34 118.4 0.2 3e-34 118.0 0.1 1.1 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.15 EFE42367.1 - 1.7e-15 56.5 0.0 3e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EFE42367.1 - 4.5e-05 23.5 0.1 0.00037 20.6 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.1 EFE42367.1 - 0.0035 16.8 0.0 0.0055 16.2 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.1 EFE42367.1 - 0.0062 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin domain DUF2847 PF11009.3 EFE42367.1 - 0.014 14.9 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) AhpC-TSA PF00578.16 EFE42367.1 - 0.03 14.0 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.5 EFE42367.1 - 0.047 13.2 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 Redoxin Thioredoxin_8 PF13905.1 EFE42367.1 - 0.085 12.9 0.0 0.41 10.7 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin-like DSBA PF01323.15 EFE42367.1 - 0.089 12.3 0.0 0.35 10.4 0.0 1.9 1 1 1 2 2 2 0 DSBA-like thioredoxin domain EF-hand_9 PF14658.1 EFE42368.1 - 0.006 16.4 0.0 4.4 7.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain Dak2 PF02734.12 EFE42368.1 - 0.05 13.2 0.0 0.099 12.3 0.0 1.5 1 1 0 1 1 1 0 DAK2 domain UCH PF00443.24 EFE42369.1 - 2.1e-34 118.9 0.0 3e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE42369.1 - 2e-10 40.6 0.0 4e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Alb1 PF09135.6 EFE42370.1 - 4.3e-27 94.9 12.0 6.8e-27 94.2 8.3 1.3 1 0 0 1 1 1 1 Alb1 Vps16_C PF04840.7 EFE42371.1 - 5.7e-68 229.2 0.2 9.7e-68 228.4 0.1 1.3 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.8 EFE42371.1 - 4.6e-55 186.8 0.0 2.5e-53 181.1 0.0 2.3 1 1 0 1 1 1 1 Vps16, N-terminal region Bestrophin PF01062.16 EFE42374.1 - 2e-44 151.6 0.0 3.5e-44 150.9 0.0 1.3 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel FHA PF00498.21 EFE42375.1 - 2e-14 53.4 0.0 4.2e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 EFE42375.1 - 0.0028 17.4 11.6 0.043 13.6 8.0 2.3 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFE42375.1 - 0.0065 16.5 6.0 0.016 15.2 4.0 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EFE42375.1 - 0.0096 15.5 4.0 0.028 14.0 2.8 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFE42375.1 - 0.026 14.3 1.3 0.061 13.1 0.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.6 EFE42375.1 - 0.18 11.8 4.7 0.51 10.3 3.2 1.8 1 0 0 1 1 1 0 RING-like domain zf-H2C2_2 PF13465.1 EFE42375.1 - 0.24 11.7 3.3 0.29 11.4 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-C3HC4_2 PF13923.1 EFE42375.1 - 2.4 8.2 10.2 0.28 11.2 3.5 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE42375.1 - 3.3 7.5 10.4 4.5 7.0 6.4 1.8 1 1 0 1 1 1 0 zinc-RING finger domain CIAPIN1 PF05093.8 EFE42376.1 - 0.047 13.7 0.0 0.096 12.7 0.0 1.5 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DUF4131 PF13567.1 EFE42377.1 - 0.01 15.2 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PrgI PF12666.2 EFE42377.1 - 0.16 12.1 1.7 0.23 11.6 1.2 1.3 1 1 0 1 1 1 0 PrgI family protein DUF2244 PF10003.4 EFE42377.1 - 0.41 10.0 5.3 0.84 9.0 0.4 2.0 1 1 1 2 2 2 0 Integral membrane protein (DUF2244) 2OG-FeII_Oxy_3 PF13640.1 EFE42378.1 - 0.0025 18.3 0.0 0.0046 17.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2527 PF10736.4 EFE42378.1 - 0.017 14.7 0.1 0.035 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) DZR PF12773.2 EFE42379.1 - 0.0029 17.4 2.4 0.53 10.1 0.8 2.3 2 0 0 2 2 2 2 Double zinc ribbon zf-C3HC4_3 PF13920.1 EFE42379.1 - 0.17 11.5 2.0 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_2 PF13240.1 EFE42379.1 - 0.27 10.7 5.8 1.9 8.0 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Apt1 PF10351.4 EFE42379.1 - 2.7 6.7 8.1 4.2 6.1 5.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain WD40 PF00400.27 EFE42380.1 - 2.1e-28 97.1 17.3 2.6e-07 30.2 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EFE42380.1 - 0.0087 14.8 1.0 2.3 6.8 0.0 2.7 2 1 0 2 2 2 2 Nup133 N terminal like Proteasome PF00227.21 EFE42381.1 - 8.6e-29 100.1 0.0 1e-28 99.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Peptidase_C97 PF05903.9 EFE42382.1 - 0.001 18.9 0.1 0.0018 18.0 0.1 1.5 2 0 0 2 2 2 1 PPPDE putative peptidase domain LRAT PF04970.8 EFE42382.1 - 0.012 15.5 0.1 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase LRRC37AB_C PF14914.1 EFE42382.1 - 0.032 13.6 1.0 0.052 12.9 0.7 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain TLD PF07534.11 EFE42383.1 - 1.8e-11 44.1 0.0 3.7e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 TLD UCH PF00443.24 EFE42384.1 - 1.1e-21 77.1 0.0 3e-20 72.4 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EFE42384.1 - 7.2e-12 45.2 0.2 1.3e-11 44.4 0.2 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 EFE42384.1 - 8.5e-05 22.1 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.27 EFE42386.1 - 7.4e-76 247.5 30.3 4.2e-09 35.9 0.2 11.5 11 2 0 11 11 11 10 WD domain, G-beta repeat Utp13 PF08625.6 EFE42386.1 - 5.4e-45 152.5 0.0 8.3e-45 151.9 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 EFE42386.1 - 1.6e-08 33.1 17.2 0.081 11.0 0.0 6.0 2 2 4 6 6 6 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFE42386.1 - 5.4e-06 25.4 8.8 0.24 10.0 0.0 5.8 4 2 0 5 5 5 4 Nup133 N terminal like G-patch_2 PF12656.2 EFE42387.1 - 3e-28 97.4 2.1 4.8e-28 96.8 0.0 2.6 2 0 0 2 2 2 1 DExH-box splicing factor binding site G-patch PF01585.18 EFE42387.1 - 8.3e-05 22.2 0.5 0.00031 20.4 0.3 2.1 1 0 0 1 1 1 1 G-patch domain HSA PF07529.8 EFE42388.1 - 2.8e-22 78.2 1.4 2.8e-22 78.2 0.9 3.1 2 0 0 2 2 2 1 HSA Myb_DNA-bind_6 PF13921.1 EFE42388.1 - 4.3e-16 58.7 0.1 4.3e-16 58.7 0.1 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFE42388.1 - 0.00021 21.2 0.1 0.00055 19.9 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.27 EFE42389.1 - 1.9e-13 49.7 0.0 0.0002 21.1 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat GTP_EFTU PF00009.22 EFE42390.1 - 3.7e-38 130.8 0.0 5.9e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 EFE42390.1 - 3.4e-36 123.1 0.1 7.1e-36 122.1 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 EFE42390.1 - 8.7e-11 41.7 0.2 1.6e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFE42390.1 - 0.014 15.3 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFE42390.1 - 0.12 12.2 0.0 0.39 10.5 0.0 1.9 2 0 0 2 2 2 0 Dynamin family RNA_polI_A14 PF08203.6 EFE42391.1 - 0.011 15.9 0.1 0.048 13.9 0.0 2.0 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 SDA1 PF05285.7 EFE42391.1 - 0.13 11.5 13.4 0.16 11.2 9.3 1.1 1 0 0 1 1 1 0 SDA1 RHIM PF12721.2 EFE42391.1 - 0.14 12.6 0.6 0.39 11.1 0.1 2.0 2 0 0 2 2 2 0 RIP homotypic interaction motif PGA2 PF07543.7 EFE42391.1 - 0.7 9.6 12.1 0.93 9.2 8.4 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 Peptidase_S49_N PF08496.5 EFE42391.1 - 1.4 8.7 6.9 2.4 7.9 4.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal NARP1 PF12569.3 EFE42391.1 - 6.1 5.4 12.4 8.8 4.9 8.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Peptidase_M48 PF01435.13 EFE42392.1 - 1.9e-49 168.2 0.0 3e-49 167.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 DUF4538 PF15061.1 EFE42392.1 - 0.019 14.2 1.5 0.045 13.0 1.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Methyltransf_2 PF00891.13 EFE42392.1 - 0.081 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Peptidase_M56 PF05569.6 EFE42392.1 - 0.46 9.4 4.2 1.3 7.8 1.4 2.5 2 1 0 2 2 2 0 BlaR1 peptidase M56 MFS_1 PF07690.11 EFE42393.1 - 8.2e-35 120.1 55.6 1.2e-33 116.2 36.8 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE42393.1 - 2.2e-05 23.2 9.6 2.2e-05 23.2 6.7 3.1 2 1 1 3 3 3 2 Sugar (and other) transporter DUF3482 PF11981.3 EFE42393.1 - 0.37 9.9 2.2 0.8 8.8 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Pox_A14 PF05767.7 EFE42393.1 - 0.68 9.9 7.4 0.19 11.7 1.1 2.9 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 Fungal_trans PF04082.13 EFE42394.1 - 3.2e-18 65.5 1.0 5.3e-18 64.8 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Abhydrolase_6 PF12697.2 EFE42395.1 - 4.3e-11 43.1 1.6 9e-11 42.0 1.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE42395.1 - 1.9e-10 40.6 0.2 4.1e-10 39.5 0.2 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFE42395.1 - 0.0001 21.9 0.2 0.00015 21.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFE42395.1 - 0.00044 19.5 0.2 0.14 11.3 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 EFE42395.1 - 0.00055 19.5 0.4 0.0008 19.0 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFE42395.1 - 0.059 13.2 0.1 0.14 12.0 0.1 1.6 1 1 0 1 1 1 0 Putative lysophospholipase Ank_2 PF12796.2 EFE42398.1 - 6e-72 238.0 1.0 1e-14 54.6 0.0 5.2 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 EFE42398.1 - 5.1e-46 152.2 2.6 0.0003 20.4 0.1 12.1 12 0 0 12 12 12 8 Ankyrin repeat Ank_4 PF13637.1 EFE42398.1 - 1.7e-44 149.4 0.3 2.2e-09 37.5 0.1 9.0 4 3 4 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE42398.1 - 7.7e-37 121.6 0.5 0.016 15.3 0.0 12.2 12 0 0 12 12 12 7 Ankyrin repeat Ank_5 PF13857.1 EFE42398.1 - 1.9e-27 94.6 3.4 2.1e-06 27.7 0.0 8.3 3 3 4 8 8 8 6 Ankyrin repeats (many copies) NACHT PF05729.7 EFE42398.1 - 0.056 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Peptidase_M16_C PF05193.16 EFE42399.1 - 1.9e-11 43.9 0.0 9.5e-09 35.1 0.0 3.0 2 1 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFE42399.1 - 5.6e-07 29.4 0.1 2e-06 27.6 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) TFIIA PF03153.8 EFE42399.1 - 0.00022 21.2 12.4 0.00033 20.6 8.6 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RQC PF09382.5 EFE42399.1 - 0.074 12.7 0.0 0.6 9.8 0.0 2.3 2 0 0 2 2 2 0 RQC domain Zw10 PF06248.8 EFE42400.1 - 1.1e-15 56.8 3.8 5.8e-15 54.4 1.6 2.2 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.3 EFE42400.1 - 5.7e-07 28.9 0.1 5.7e-07 28.9 0.1 2.0 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal DUF310 PF03750.8 EFE42400.1 - 0.032 14.4 0.9 0.093 12.9 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF310) ING PF12998.2 EFE42400.1 - 0.92 9.8 8.4 0.98 9.7 1.8 2.6 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Nop14 PF04147.7 EFE42400.1 - 1.3 6.8 26.1 0.0057 14.6 12.0 1.4 2 0 0 2 2 2 0 Nop14-like family WD40 PF00400.27 EFE42401.1 - 1.2e-26 91.5 22.0 2.6e-07 30.2 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat NLE PF08154.7 EFE42401.1 - 1.6e-18 66.4 0.1 2.8e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Ribosomal_S13 PF00416.17 EFE42402.1 - 3.3e-15 56.4 0.2 3.9e-15 56.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Pro_isomerase PF00160.16 EFE42403.1 - 4.6e-37 127.6 1.2 7e-37 127.0 0.9 1.3 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD COesterase PF00135.23 EFE42404.1 - 6.8e-109 364.9 0.0 9e-109 364.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE42404.1 - 3.8e-06 26.6 0.0 6.5e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFE42404.1 - 0.00055 19.2 0.0 0.001 18.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Fungal_trans_2 PF11951.3 EFE42405.1 - 4.8e-06 25.4 0.0 3.5e-05 22.5 0.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF4644 PF15486.1 EFE42406.1 - 0.18 11.7 1.2 0.25 11.3 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4644) DEAD PF00270.24 EFE42407.1 - 2.4e-46 157.3 0.0 7.7e-45 152.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE42407.1 - 4e-28 97.0 0.1 7.4e-28 96.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE42407.1 - 0.1 12.3 0.0 0.29 10.9 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.1 EFE42407.1 - 0.17 10.8 0.0 0.32 10.0 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF1253 PF06862.7 EFE42407.1 - 0.34 9.2 0.0 0.59 8.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) INSIG PF07281.7 EFE42409.1 - 6.3e-58 195.3 3.7 7.9e-58 194.9 2.6 1.1 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) DUF898 PF05987.8 EFE42409.1 - 0.11 11.3 2.9 0.23 10.3 2.0 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Clathrin PF00637.15 EFE42410.1 - 1.9e-199 653.2 35.4 1.8e-35 121.6 0.6 7.4 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 EFE42410.1 - 7.5e-29 99.4 0.2 2.8e-28 97.5 0.1 2.1 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.15 EFE42410.1 - 7.2e-26 88.6 3.6 0.00022 21.2 0.0 6.9 6 0 0 6 6 6 5 Clathrin propeller repeat TPR_14 PF13428.1 EFE42410.1 - 0.00056 20.3 8.9 3.6 8.4 0.2 7.7 12 0 0 12 12 12 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFE42410.1 - 0.0063 16.8 3.3 44 4.4 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 EFE42410.1 - 0.0077 15.9 6.8 33 4.5 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat Ank_3 PF13606.1 EFE42410.1 - 0.047 13.9 0.0 1.1 9.7 0.0 3.4 2 0 0 2 2 2 0 Ankyrin repeat UvrC_HhH_N PF08459.6 EFE42411.1 - 0.069 12.6 0.4 0.079 12.5 0.3 1.1 1 0 0 1 1 1 0 UvrC Helix-hairpin-helix N-terminal FlxA PF14282.1 EFE42411.1 - 0.14 12.0 6.4 0.29 11.0 4.4 1.5 1 0 0 1 1 1 0 FlxA-like protein Protocadherin PF08374.6 EFE42411.1 - 0.9 9.1 7.3 1.1 8.8 5.0 1.2 1 0 0 1 1 1 0 Protocadherin Ribosomal_S17 PF00366.15 EFE42411.1 - 4.5 7.4 7.2 3.3 7.8 3.6 1.8 1 1 1 2 2 2 0 Ribosomal protein S17 CPSase_L_D2 PF02786.12 EFE42412.1 - 1.4e-80 269.5 0.1 2.2e-80 268.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 EFE42412.1 - 1.2e-66 223.9 0.0 2e-66 223.1 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 EFE42412.1 - 6.1e-36 122.8 0.0 1.3e-35 121.8 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EFE42412.1 - 5.8e-31 106.6 0.0 1.9e-30 105.0 0.0 1.9 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 EFE42412.1 - 1.3e-23 83.8 0.0 2.7e-23 82.8 0.0 1.6 1 0 0 1 1 1 1 HMGL-like ATP-grasp_4 PF13535.1 EFE42412.1 - 2.3e-17 63.3 0.1 4.6e-17 62.3 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 EFE42412.1 - 3.4e-17 61.8 4.4 3.5e-17 61.7 2.0 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 EFE42412.1 - 1.1e-16 60.5 0.0 3.9e-16 58.7 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 EFE42412.1 - 6.5e-10 38.5 3.6 3.3e-06 26.6 0.1 2.9 2 1 1 3 3 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 EFE42412.1 - 2.9e-09 36.6 0.0 5.7e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 EFE42412.1 - 1.2e-06 27.9 0.0 2.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 EFE42412.1 - 2e-06 27.4 0.0 4.5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 EFE42412.1 - 0.00013 21.8 0.0 0.00031 20.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_2 PF12700.2 EFE42412.1 - 0.0016 17.6 0.0 0.99 8.4 0.0 2.2 1 1 1 2 2 2 2 HlyD family secretion protein HlyD_3 PF13437.1 EFE42412.1 - 0.0042 17.4 0.2 0.059 13.7 0.1 2.9 2 1 0 2 2 2 1 HlyD family secretion protein HlyD PF00529.15 EFE42412.1 - 0.013 14.7 0.0 0.065 12.5 0.1 2.1 2 0 0 2 2 2 0 HlyD family secretion protein DUF2118 PF09891.4 EFE42412.1 - 0.032 13.9 0.1 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) SUI1 PF01253.17 EFE42412.1 - 0.12 12.1 0.0 27 4.6 0.0 2.7 2 0 0 2 2 2 0 Translation initiation factor SUI1 Ribosomal_L5_C PF00673.16 EFE42413.1 - 1.1e-22 79.5 0.0 1.6e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 EFE42413.1 - 2.1e-21 75.4 0.1 7.4e-21 73.6 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 LSM PF01423.17 EFE42414.1 - 2.7e-05 23.6 0.0 3.3e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain Aa_trans PF01490.13 EFE42416.1 - 2.6e-84 283.0 34.8 3.1e-84 282.8 24.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3687 PF12459.3 EFE42416.1 - 0.22 10.7 3.0 0.78 9.0 2.1 2.0 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein Glycophorin_A PF01102.13 EFE42416.1 - 1.6 8.4 6.2 1.2 8.9 0.2 3.2 3 1 1 4 4 4 0 Glycophorin A AA_permease PF00324.16 EFE42417.1 - 1.4e-52 178.6 32.9 1.7e-52 178.3 22.8 1.1 1 0 0 1 1 1 1 Amino acid permease PP1c_bdg PF10488.4 EFE42417.1 - 0.13 11.4 2.6 0.25 10.4 1.8 1.4 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region GHMP_kinases_N PF00288.21 EFE42418.1 - 1.2e-18 66.9 0.3 9.2e-18 64.0 0.0 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EFE42418.1 - 1.5e-09 37.8 0.0 3.8e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.4 EFE42418.1 - 0.0092 15.2 0.0 0.022 14.0 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature PPTA PF01239.17 EFE42419.1 - 0.00026 20.2 0.0 0.00045 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein prenyltransferase alpha subunit repeat PPTA PF01239.17 EFE42420.1 - 1.5e-25 87.4 0.6 3.7e-10 38.7 0.4 3.5 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat PALP PF00291.20 EFE42421.1 - 4.8e-53 180.3 0.2 1.8e-52 178.4 0.0 2.0 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme PEP_mutase PF13714.1 EFE42421.1 - 0.081 12.1 0.1 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase AlaDh_PNT_C PF01262.16 EFE42421.1 - 0.12 11.9 0.1 0.49 9.9 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain tRNA-synt_1g PF09334.6 EFE42422.1 - 2.6e-67 227.1 0.0 3.6e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EFE42422.1 - 5.7e-14 51.0 0.0 2.6e-12 45.5 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EFE42422.1 - 0.0079 15.9 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 EFE42422.1 - 0.024 13.7 0.0 0.054 12.6 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Ribosomal_L38e PF01781.13 EFE42423.1 - 1.2e-31 108.2 1.7 1.4e-31 108.0 1.2 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Acetyltransf_3 PF13302.1 EFE42424.1 - 1.1e-19 71.0 0.1 4.6e-18 65.7 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE42424.1 - 7.8e-05 22.3 0.2 0.036 13.8 0.0 2.5 1 1 0 2 2 2 2 FR47-like protein Acetyltransf_4 PF13420.1 EFE42424.1 - 0.0005 20.0 0.1 0.0064 16.4 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFE42424.1 - 0.015 15.1 0.3 0.43 10.4 0.0 2.8 3 1 1 4 4 4 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE42424.1 - 0.048 13.6 0.1 1.5 8.9 0.1 2.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family DNA_pol_E_B PF04042.11 EFE42425.1 - 2.8e-44 150.8 0.0 8.3e-44 149.3 0.0 1.8 2 1 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B NMO PF03060.10 EFE42426.1 - 8e-74 248.7 0.4 9.3e-74 248.5 0.3 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFE42426.1 - 4.5e-06 25.8 0.0 0.0084 15.0 0.1 2.7 3 0 0 3 3 3 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EFE42426.1 - 0.00075 18.4 2.0 0.0012 17.7 1.4 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase ATP_synt_I PF03899.10 EFE42426.1 - 0.13 12.4 0.3 0.22 11.6 0.2 1.3 1 0 0 1 1 1 0 ATP synthase I chain DUF627 PF04781.7 EFE42426.1 - 0.13 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF627) Taxilin PF09728.4 EFE42427.1 - 1.6e-97 326.3 52.8 1.6e-97 326.3 36.6 2.3 2 1 0 2 2 2 1 Myosin-like coiled-coil protein DUF241 PF03087.9 EFE42427.1 - 0.009 15.5 27.1 0.092 12.2 8.5 2.2 2 0 0 2 2 2 2 Arabidopsis protein of unknown function DUF948 PF06103.6 EFE42427.1 - 0.21 11.4 17.1 0.75 9.6 0.3 4.1 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.3 EFE42427.1 - 0.25 11.0 51.8 0.12 12.0 9.7 4.3 2 2 1 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF3584 PF12128.3 EFE42427.1 - 0.25 8.6 45.6 0.24 8.6 30.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Laminin_II PF06009.7 EFE42427.1 - 7.6 6.2 33.0 0.81 9.4 3.0 4.2 1 1 2 4 4 4 0 Laminin Domain II M16C_assoc PF08367.6 EFE42428.1 - 7.9e-56 188.6 0.0 1.7e-55 187.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 EFE42428.1 - 3.1e-29 101.9 0.0 4.5e-16 59.0 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFE42428.1 - 8e-10 38.6 0.0 4.8e-09 36.1 0.0 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) zf-HC2 PF13490.1 EFE42428.1 - 0.11 12.5 0.4 8.3 6.4 0.1 2.6 2 0 0 2 2 2 0 Putative zinc-finger DUF1510 PF07423.6 EFE42430.1 - 0.0053 16.1 5.7 0.0053 16.1 4.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) PgaD PF13994.1 EFE42430.1 - 0.0055 16.1 1.5 0.0055 16.1 1.0 1.9 2 1 0 2 2 2 1 PgaD-like protein CCER1 PF15482.1 EFE42430.1 - 0.01 15.4 1.4 0.014 15.0 0.5 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 DUF2217 PF10265.4 EFE42430.1 - 0.028 13.2 4.7 0.033 12.9 3.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Hph PF13694.1 EFE42430.1 - 0.028 14.4 0.8 0.044 13.8 0.5 1.3 1 0 0 1 1 1 0 Sec63/Sec62 complex-interacting family FHIPEP PF00771.15 EFE42430.1 - 0.042 12.2 1.9 0.052 11.8 1.3 1.1 1 0 0 1 1 1 0 FHIPEP family DUF2235 PF09994.4 EFE42430.1 - 0.12 11.6 2.8 0.11 11.8 1.3 1.3 1 1 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Neur_chan_memb PF02932.11 EFE42430.1 - 0.41 10.5 3.0 0.58 9.9 2.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EphA2_TM PF14575.1 EFE42430.1 - 1.9 8.9 5.7 7.2 7.0 3.3 2.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Rtf2 PF04641.7 EFE42430.1 - 1.9 7.6 12.7 2.7 7.1 8.8 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Paramyxo_NS_C PF02725.9 EFE42430.1 - 2.1 7.9 7.8 3.4 7.2 5.4 1.3 1 0 0 1 1 1 0 Non-structural protein C Trp_oprn_chp PF09534.5 EFE42430.1 - 3 7.4 7.8 0.37 10.3 2.2 1.8 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2500 PF10694.4 EFE42430.1 - 4.8 7.2 6.6 9.3 6.3 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2500) Atrophin-1 PF03154.10 EFE42430.1 - 5.1 5.1 15.0 6.2 4.8 10.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family MRI PF15325.1 EFE42430.1 - 5.1 8.1 10.7 0.87 10.5 4.1 2.1 1 1 1 2 2 2 0 Modulator of retrovirus infection Ctr PF04145.10 EFE42430.1 - 5.3 7.0 6.7 10 6.1 4.7 1.5 1 1 0 1 1 1 0 Ctr copper transporter family AIF_C PF14721.1 EFE42430.1 - 8.4 6.6 6.8 6.9 6.9 3.6 1.7 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Cation_efflux PF01545.16 EFE42431.1 - 7.9e-59 199.0 0.0 1.5e-58 198.1 0.0 1.4 1 1 0 1 1 1 1 Cation efflux family CorA PF01544.13 EFE42432.1 - 0.075 12.0 0.4 0.15 11.0 0.3 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein YqfQ PF14181.1 EFE42433.1 - 0.3 11.0 6.7 0.58 10.1 2.9 2.0 2 0 0 2 2 2 0 YqfQ-like protein CDC45 PF02724.9 EFE42433.1 - 1 7.3 10.2 0.12 10.3 2.3 1.9 2 0 0 2 2 2 0 CDC45-like protein TRAP_alpha PF03896.11 EFE42433.1 - 1.5 7.7 6.4 0.096 11.6 0.6 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit HSP90 PF00183.13 EFE42433.1 - 1.7 6.9 10.3 0.031 12.6 2.7 1.3 2 0 0 2 2 2 0 Hsp90 protein NOA36 PF06524.7 EFE42433.1 - 4.7 6.3 12.0 6 6.0 3.6 2.1 2 0 0 2 2 2 0 NOA36 protein CENP-B_dimeris PF09026.5 EFE42433.1 - 6.2 7.1 15.6 6.4 7.0 5.9 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Nucleoplasmin PF03066.10 EFE42433.1 - 8.9 5.8 16.9 0.71 9.3 7.7 1.8 2 0 0 2 2 2 0 Nucleoplasmin DUF4407 PF14362.1 EFE42435.1 - 0.52 9.2 4.3 0.6 9.0 3.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAPS PF04499.10 EFE42435.1 - 3.4 6.1 5.4 3.7 6.0 3.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pox_Ag35 PF03286.9 EFE42435.1 - 5.3 6.5 10.1 5.8 6.3 7.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CK1gamma_C PF12605.3 EFE42435.1 - 8.3 7.0 6.7 1.3e+02 3.2 4.7 2.0 1 1 0 1 1 1 0 Casein kinase 1 gamma C terminal Myb_DNA-binding PF00249.26 EFE42436.1 - 3.6e-24 84.5 0.6 3.5e-12 46.1 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFE42436.1 - 2.6e-19 69.0 6.0 1.9e-13 50.2 0.0 2.9 2 1 1 3 3 3 2 Myb-like DNA-binding domain HTH_23 PF13384.1 EFE42436.1 - 0.058 13.0 0.2 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Homeodomain-like domain DUF2774 PF11242.3 EFE42436.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Myb_DNA-bind_4 PF13837.1 EFE42436.1 - 0.15 12.2 0.0 0.15 12.2 0.0 2.8 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain ABC_tran PF00005.22 EFE42437.1 - 8.8e-29 100.5 0.0 8.7e-16 58.4 0.0 3.7 3 1 0 3 3 3 2 ABC transporter ABC_membrane PF00664.18 EFE42437.1 - 4.5e-25 88.5 28.1 6.2e-18 65.1 4.5 3.9 4 0 0 4 4 4 2 ABC transporter transmembrane region SMC_N PF02463.14 EFE42437.1 - 1.4e-08 34.2 0.0 0.00025 20.3 0.0 3.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 EFE42437.1 - 0.0019 18.1 0.0 10 6.1 0.0 3.8 3 0 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.1 EFE42437.1 - 0.022 15.1 0.1 0.045 14.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 EFE42437.1 - 0.023 14.6 0.2 4.5 7.1 0.0 3.2 2 1 0 3 3 3 0 AAA domain AAA_22 PF13401.1 EFE42437.1 - 0.056 13.5 0.0 0.72 9.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EFE42437.1 - 0.073 12.2 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Cu-oxidase_3 PF07732.10 EFE42438.1 - 1e-11 44.5 0.6 9.3e-08 31.8 0.2 2.6 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFE42438.1 - 6.8e-05 22.4 0.1 0.033 13.6 0.0 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EFE42438.1 - 0.0064 16.4 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase DUF2414 PF10309.4 EFE42439.1 - 1.3e-25 88.8 0.1 2.3e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2414) ATP-synt_DE_N PF02823.11 EFE42440.1 - 1.4e-14 53.5 0.1 1.6e-12 47.0 0.0 2.2 2 0 0 2 2 2 2 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Corona_nucleoca PF00937.13 EFE42441.1 - 0.0011 17.9 1.1 0.0011 17.9 0.8 2.5 2 1 0 2 2 2 1 Coronavirus nucleocapsid protein DUF1777 PF08648.7 EFE42441.1 - 0.014 15.1 2.1 0.014 15.1 1.5 4.1 3 1 0 4 4 4 0 Protein of unknown function (DUF1777) DUF3180 PF11377.3 EFE42441.1 - 0.12 12.2 0.2 0.12 12.2 0.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3180) APH PF01636.18 EFE42442.1 - 4.1e-15 56.1 0.0 4.6e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE42442.1 - 0.0044 16.1 0.0 0.0072 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-H2C2_2 PF13465.1 EFE42445.1 - 0.049 13.9 15.3 0.16 12.3 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger double domain Mem_trans PF03547.13 EFE42445.1 - 8.6 4.5 9.9 0.33 9.2 0.1 2.5 3 0 0 3 3 3 0 Membrane transport protein PQ-loop PF04193.9 EFE42446.1 - 1.2e-28 98.4 17.3 1.3e-17 63.1 0.9 2.9 3 0 0 3 3 3 2 PQ loop repeat ERGIC_N PF13850.1 EFE42446.1 - 0.016 15.1 0.1 0.11 12.5 0.0 2.3 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF3429 PF11911.3 EFE42446.1 - 0.028 14.3 2.9 0.042 13.8 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3429) DUF2776 PF10951.3 EFE42446.1 - 0.57 9.1 7.5 11 4.9 3.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2776) Phos_pyr_kin PF08543.7 EFE42447.1 - 8.4e-12 44.7 0.0 1.9e-11 43.6 0.0 1.7 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 EFE42447.1 - 4.6e-08 32.5 0.0 2.5e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 pfkB family carbohydrate kinase BON PF04972.12 EFE42447.1 - 0.17 11.6 1.1 1.4 8.7 0.0 2.5 2 0 0 2 2 2 0 BON domain dUTPase PF00692.14 EFE42448.1 - 4.8e-33 113.3 0.0 6.8e-33 112.8 0.0 1.2 1 0 0 1 1 1 1 dUTPase ADIP PF11559.3 EFE42449.1 - 1.4e-30 106.1 21.8 2e-21 76.4 9.1 3.3 4 0 0 4 4 4 2 Afadin- and alpha -actinin-Binding Spc7 PF08317.6 EFE42449.1 - 0.33 9.5 10.3 0.97 8.0 7.2 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein RasGAP_C PF03836.10 EFE42449.1 - 0.88 9.2 9.4 1.5 8.5 0.7 2.7 1 1 0 2 2 2 0 RasGAP C-terminus Fib_alpha PF08702.5 EFE42449.1 - 3 7.9 10.5 0.94 9.6 4.1 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family IncA PF04156.9 EFE42449.1 - 5.8 6.4 19.0 8.1 5.9 0.7 2.6 2 1 0 2 2 2 0 IncA protein SAM_2 PF07647.12 EFE42450.1 - 2.5e-08 33.6 0.0 4.7e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EFE42450.1 - 0.00013 22.0 0.6 0.00025 21.1 0.1 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DnaJ PF00226.26 EFE42452.1 - 5.1e-12 45.3 0.4 1.8e-11 43.6 0.2 2.0 1 1 0 1 1 1 1 DnaJ domain ADP_ribosyl_GH PF03747.9 EFE42454.1 - 1.8e-51 175.6 0.0 2.9e-51 174.9 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase BcrAD_BadFG PF01869.15 EFE42455.1 - 2.5e-11 43.4 0.0 5.6e-11 42.2 0.0 1.6 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family SIS PF01380.17 EFE42455.1 - 0.00013 21.5 0.0 0.00031 20.3 0.0 1.6 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.1 EFE42455.1 - 0.0033 17.1 0.0 0.0068 16.1 0.0 1.5 1 0 0 1 1 1 1 SIS domain MFS_1 PF07690.11 EFE42456.1 - 1.1e-10 40.8 40.6 1.1e-10 40.8 28.1 2.1 1 1 2 3 3 3 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFE42456.1 - 4.7e-06 26.1 8.0 4.7e-06 26.1 5.6 3.8 2 2 1 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 EFE42457.1 - 5.2e-33 114.2 27.6 5.2e-33 114.2 19.1 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE42457.1 - 5.3e-09 35.1 9.6 5.3e-09 35.1 6.7 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter CFEM PF05730.6 EFE42458.1 - 1.9e-09 37.1 12.9 3.1e-09 36.5 9.0 1.3 1 0 0 1 1 1 1 CFEM domain Ilm1 PF10311.4 EFE42460.1 - 1.8e-19 69.8 0.0 5.7e-19 68.2 0.0 1.8 1 1 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 Phosphoprotein PF00922.12 EFE42460.1 - 0.068 12.3 3.9 0.1 11.7 2.7 1.2 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein Prenyltrans_2 PF13249.1 EFE42461.1 - 4.1e-18 65.8 0.0 2.9e-15 56.6 0.0 3.6 3 1 1 4 4 4 2 Prenyltransferase-like Prenyltrans PF00432.16 EFE42461.1 - 2e-15 56.0 18.5 2.1e-05 23.9 0.0 6.4 7 0 0 7 7 7 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 EFE42461.1 - 0.0001 22.2 0.0 0.0054 16.7 0.0 3.1 2 2 1 3 3 3 1 Prenyltransferase-like Pkinase PF00069.20 EFE42462.1 - 2.5e-67 226.7 0.0 2.5e-67 226.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42462.1 - 1.6e-41 142.0 0.0 2.4e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE42462.1 - 5.1e-10 38.7 0.0 5.2e-08 32.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 EFE42462.1 - 0.0017 17.4 0.4 0.015 14.3 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE42462.1 - 0.024 14.3 8.1 2 8.0 0.1 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.17 EFE42462.1 - 2.1 7.6 4.7 0.84 8.9 0.0 2.2 2 0 0 2 2 2 0 RIO1 family MFS_1 PF07690.11 EFE42463.1 - 1.9e-13 49.8 35.5 8.9e-12 44.3 24.9 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily HlyIII PF03006.15 EFE42463.1 - 0.0001 21.8 8.5 0.002 17.5 0.2 3.1 2 1 1 3 3 3 2 Haemolysin-III related DUF4293 PF14126.1 EFE42463.1 - 0.47 10.3 9.7 0.092 12.6 2.6 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4293) DUF373 PF04123.8 EFE42463.1 - 0.64 8.9 5.6 0.81 8.6 3.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF3812 PF12757.2 EFE42464.1 - 1.1e-31 109.4 2.2 1.1e-31 109.4 1.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3812) Trypsin_2 PF13365.1 EFE42465.1 - 3.1e-15 56.2 0.0 5.3e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_C4 PF00863.14 EFE42465.1 - 0.00026 20.0 0.0 0.017 14.0 0.0 2.1 2 0 0 2 2 2 2 Peptidase family C4 Trypsin PF00089.21 EFE42465.1 - 0.001 18.7 0.1 0.0026 17.3 0.1 1.7 1 1 0 1 1 1 1 Trypsin Peptidase_S32 PF05579.8 EFE42465.1 - 0.11 11.4 0.1 0.55 9.1 0.0 1.9 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 DUF1640 PF07798.6 EFE42466.1 - 2.4e-54 184.0 8.7 3.5e-54 183.5 6.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) PMM PF03332.8 EFE42467.1 - 3.5e-104 347.1 0.1 4.1e-104 346.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 EFE42467.1 - 5.6e-06 26.1 0.0 1.8e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMPIT PF07851.8 EFE42467.1 - 0.0004 19.5 0.1 0.00059 19.0 0.1 1.2 1 0 0 1 1 1 1 TMPIT-like protein MFS_1 PF07690.11 EFE42468.1 - 2e-38 132.0 50.0 5.3e-38 130.6 34.7 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DnaJ PF00226.26 EFE42469.1 - 8.9e-10 38.1 0.3 1.5e-09 37.4 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain DUF2076 PF09849.4 EFE42469.1 - 0.00023 21.2 0.1 0.00029 20.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF456 PF04306.8 EFE42469.1 - 0.00064 19.7 0.6 0.001 19.1 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF456) DEC-1_C PF04626.8 EFE42469.1 - 0.087 12.9 0.3 0.14 12.3 0.2 1.3 1 0 0 1 1 1 0 Dec-1 protein, C terminal region IFP_35_N PF07334.8 EFE42469.1 - 0.097 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Gly-zipper_OmpA PF13436.1 EFE42469.1 - 0.65 9.6 3.0 1.5 8.4 2.0 1.7 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Bacteriocin_IIc PF10439.4 EFE42469.1 - 9.5 6.4 13.5 17 5.6 9.2 1.5 1 1 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Macoilin PF09726.4 EFE42470.1 - 4.2 5.5 7.4 5.2 5.2 5.1 1.0 1 0 0 1 1 1 0 Transmembrane protein MBOAT_2 PF13813.1 EFE42471.1 - 2e-18 66.2 4.6 2e-18 66.2 3.2 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Peptidase_S8 PF00082.17 EFE42473.1 - 1.4e-44 152.3 13.8 2.2e-44 151.7 9.6 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE42473.1 - 1.8e-16 60.4 0.3 3.4e-16 59.5 0.2 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 E1-E2_ATPase PF00122.15 EFE42474.1 - 4.3e-67 225.5 6.2 1e-64 217.7 4.5 2.6 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE42474.1 - 8e-46 155.8 7.9 8e-46 155.8 5.5 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE42474.1 - 5.4e-31 108.6 0.0 5.1e-30 105.5 0.0 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFE42474.1 - 4.5e-20 70.8 0.0 1.5e-19 69.2 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 EFE42474.1 - 2.8e-19 68.8 0.0 5.7e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE42474.1 - 8.9e-16 58.6 0.0 3.3e-15 56.7 0.0 2.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE42474.1 - 6.1e-08 32.5 1.6 9e-06 25.4 0.7 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFE42474.1 - 0.026 14.7 0.0 0.076 13.2 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase adh_short PF00106.20 EFE42475.1 - 1.3e-14 54.5 0.0 2.1e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE42475.1 - 7.8e-05 22.4 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE42475.1 - 0.017 14.5 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 14-3-3 PF00244.15 EFE42476.1 - 1.1e-95 319.2 6.6 1.4e-56 191.2 0.6 2.1 1 1 1 2 2 2 2 14-3-3 protein Mgr1 PF08602.5 EFE42476.1 - 0.029 13.3 0.5 0.058 12.4 0.3 1.4 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit eIF3_subunit PF08597.5 EFE42477.1 - 4.9e-63 212.9 27.0 4.9e-63 212.9 18.7 2.2 2 0 0 2 2 2 2 Translation initiation factor eIF3 subunit Enolase_C PF00113.17 EFE42478.1 - 1.4e-152 506.8 0.0 1.8e-152 506.4 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 EFE42478.1 - 7.2e-35 119.7 0.1 1.3e-34 118.9 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE PF01188.16 EFE42478.1 - 0.053 14.0 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain VSP PF03302.8 EFE42478.1 - 0.08 11.5 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein Brevenin PF03032.10 EFE42479.1 - 0.7 9.7 3.1 0.97 9.3 2.1 1.3 1 0 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family E1-E2_ATPase PF00122.15 EFE42480.1 - 7.3e-48 162.5 1.8 1.7e-47 161.4 1.2 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE42480.1 - 1.2e-43 148.7 3.8 1.2e-43 148.7 2.6 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE42480.1 - 5.5e-32 111.9 0.0 1.9e-31 110.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE42480.1 - 1.3e-19 69.9 0.0 2.6e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE42480.1 - 3.9e-14 53.2 0.0 9.2e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFE42480.1 - 1.8e-12 46.5 0.0 3.8e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EFE42480.1 - 0.0001 21.9 0.2 0.00041 20.0 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase MIP-T3 PF10243.4 EFE42480.1 - 1.6 7.1 3.4 2.2 6.6 2.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 AAA PF00004.24 EFE42481.1 - 1.8e-39 134.9 0.0 3.4e-39 134.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFE42481.1 - 1.5e-07 31.6 0.0 1.2e-05 25.4 0.0 2.6 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.1 EFE42481.1 - 2.8e-07 30.7 0.0 7.4e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFE42481.1 - 2.1e-06 27.5 0.0 1.7e-05 24.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFE42481.1 - 1.1e-05 25.4 0.0 3.8e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 EFE42481.1 - 0.00058 19.5 0.1 0.0014 18.3 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 EFE42481.1 - 0.00085 19.0 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain RuvB_N PF05496.7 EFE42481.1 - 0.00096 18.2 0.0 0.002 17.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EFE42481.1 - 0.00096 19.9 0.5 0.0029 18.4 0.1 2.2 2 1 0 2 2 1 1 AAA domain AAA_25 PF13481.1 EFE42481.1 - 0.002 17.5 0.1 0.017 14.5 0.0 2.2 1 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 EFE42481.1 - 0.0038 17.3 0.0 0.0071 16.5 0.0 1.5 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.12 EFE42481.1 - 0.0039 16.6 0.0 0.0086 15.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 EFE42481.1 - 0.005 16.0 0.0 0.0098 15.0 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF4200 PF13863.1 EFE42481.1 - 0.0061 16.4 0.3 0.016 15.1 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) AAA_18 PF13238.1 EFE42481.1 - 0.0071 16.6 0.2 0.035 14.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFE42481.1 - 0.0076 16.1 0.0 0.025 14.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EFE42481.1 - 0.012 14.6 0.0 0.03 13.4 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.1 EFE42481.1 - 0.02 14.4 0.1 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 EFE42481.1 - 0.022 13.5 0.0 0.041 12.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_3 PF07726.6 EFE42481.1 - 0.023 14.3 0.0 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 EFE42481.1 - 0.025 13.6 0.1 0.12 11.4 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_13 PF13166.1 EFE42481.1 - 0.048 12.1 0.0 0.8 8.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 EFE42481.1 - 0.052 13.1 0.2 0.32 10.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.1 EFE42481.1 - 0.055 13.3 0.0 0.24 11.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 EFE42481.1 - 0.055 12.6 0.0 0.099 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.1 EFE42481.1 - 0.068 13.1 0.1 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 EFE42481.1 - 0.088 11.7 0.0 0.24 10.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Thymidylate_kin PF02223.12 EFE42481.1 - 0.089 12.1 0.1 15 4.9 0.0 3.0 2 1 1 3 3 3 0 Thymidylate kinase Parvo_NS1 PF01057.12 EFE42481.1 - 0.097 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.21 EFE42481.1 - 0.1 12.0 0.1 0.39 10.1 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_23 PF13476.1 EFE42481.1 - 0.16 12.3 2.8 5.4 7.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain IncA PF04156.9 EFE42481.1 - 0.19 11.3 1.8 0.36 10.4 1.2 1.3 1 0 0 1 1 1 0 IncA protein Glyco_hydro_47 PF01532.15 EFE42482.1 - 1e-153 512.2 0.0 1.5e-153 511.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 M20_dimer PF07687.9 EFE42483.1 - 3.4e-21 75.0 0.0 1.1e-20 73.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 EFE42483.1 - 9.2e-19 67.6 2.9 2.9e-18 66.0 2.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 EFE42483.1 - 0.0003 19.6 0.0 0.0024 16.6 0.0 2.2 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase DUF373 PF04123.8 EFE42483.1 - 0.052 12.5 0.4 0.085 11.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) HATPase_c PF02518.21 EFE42484.1 - 2.5e-18 65.7 0.0 5.1e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EFE42484.1 - 1.2e-13 50.9 0.4 3.6e-08 33.4 0.1 3.5 2 1 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.20 EFE42484.1 - 3.2e-05 23.8 0.1 0.00015 21.6 0.1 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.1 EFE42484.1 - 0.073 12.7 0.0 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_L36e PF01158.13 EFE42485.1 - 6.6e-38 128.6 7.3 7.5e-38 128.4 5.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e MRP-L28 PF09812.4 EFE42485.1 - 0.13 12.0 1.7 0.15 11.8 1.0 1.3 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L28 LemA PF04011.7 EFE42485.1 - 0.17 10.9 0.6 0.19 10.7 0.4 1.1 1 0 0 1 1 1 0 LemA family TUG-UBL1 PF11470.3 EFE42486.1 - 1.4e-24 85.7 0.0 3.4e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 GLUT4 regulating protein TUG UBX PF00789.15 EFE42486.1 - 2e-05 24.5 0.1 0.00014 21.8 0.0 2.4 3 0 0 3 3 3 1 UBX domain RBD PF02196.10 EFE42486.1 - 0.012 15.3 0.0 0.046 13.4 0.0 1.9 2 0 0 2 2 2 0 Raf-like Ras-binding domain DUF605 PF04652.11 EFE42486.1 - 1.5 8.0 15.0 0.1 11.9 7.0 1.5 2 0 0 2 2 2 0 Vta1 like Proteasome PF00227.21 EFE42487.1 - 1.5e-41 141.7 0.0 1.8e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit NatB_MDM20 PF09797.4 EFE42488.1 - 2.8e-84 282.9 1.0 4.1e-84 282.3 0.7 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.1 EFE42488.1 - 2.3e-05 24.6 7.6 0.045 14.0 0.4 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE42488.1 - 0.0019 18.7 9.8 0.43 11.3 0.1 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFE42488.1 - 2.8 8.8 12.3 42 5.1 0.1 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Methyltransf_23 PF13489.1 EFE42490.1 - 6.3e-10 38.9 0.0 1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain WD40 PF00400.27 EFE42491.1 - 0.024 14.5 0.0 0.76 9.7 0.0 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat eIF2A PF08662.6 EFE42491.1 - 0.098 12.3 0.1 0.47 10.1 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A RNA_pol_Rpb1_1 PF04997.7 EFE42492.1 - 1.9e-117 392.2 0.0 3.1e-117 391.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 EFE42492.1 - 2e-105 352.0 0.1 3.9e-105 351.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EFE42492.1 - 9.8e-69 230.5 0.0 2.5e-68 229.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 EFE42492.1 - 1.2e-63 214.3 1.2 2.6e-63 213.1 0.8 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 EFE42492.1 - 4.6e-47 159.6 0.0 1.1e-46 158.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 EFE42492.1 - 6.6e-42 142.4 5.9 6.6e-42 142.4 4.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 EFE42492.1 - 5.6e-38 128.9 0.2 1.2e-37 127.9 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 EFE42492.1 - 4.7e-10 38.7 196.7 0.03 14.4 7.1 14.8 12 2 2 15 15 15 10 RNA polymerase Rpb1 C-terminal repeat LMBR1 PF04791.11 EFE42493.1 - 3.5 6.1 4.7 4.1 5.8 3.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein PilJ PF13675.1 EFE42494.1 - 3.8 7.8 8.5 1 9.7 2.5 2.4 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term GAS PF13851.1 EFE42494.1 - 8.8 5.4 39.7 0.88 8.7 7.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding LNS2 PF08235.8 EFE42495.1 - 1.7e-70 235.6 0.0 2.7e-70 235.0 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 EFE42495.1 - 2.9e-21 75.2 0.0 2.9e-10 39.7 0.0 2.7 3 0 0 3 3 3 2 lipin, N-terminal conserved region Acid_phosphat_B PF03767.9 EFE42495.1 - 0.019 14.3 0.0 0.13 11.6 0.0 2.2 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) TFIID-31kDa PF02291.10 EFE42496.1 - 2.1e-29 101.9 0.0 8.8e-23 80.4 0.0 3.0 2 1 0 2 2 2 2 Transcription initiation factor IID, 31kD subunit Utp11 PF03998.8 EFE42498.1 - 8.1e-54 183.0 30.7 1.2e-53 182.4 21.3 1.2 1 0 0 1 1 1 1 Utp11 protein TRAM_LAG1_CLN8 PF03798.11 EFE42499.1 - 4.9e-36 124.1 19.0 8.6e-36 123.3 13.2 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 EFE42499.1 - 9.1e-22 76.3 0.1 2.1e-21 75.1 0.0 1.7 2 0 0 2 2 2 1 TRAM1-like protein Mitofilin PF09731.4 EFE42500.1 - 0.07 11.7 18.3 0.071 11.7 12.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1510 PF07423.6 EFE42500.1 - 1.4 8.1 20.9 2.4 7.5 14.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Hid1 PF12722.2 EFE42500.1 - 3.2 5.3 7.2 3.2 5.3 5.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HEAT PF02985.17 EFE42501.1 - 7e-12 44.3 2.2 0.25 11.5 0.0 7.2 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.1 EFE42501.1 - 5.6e-10 39.3 7.6 0.25 11.6 0.1 6.8 6 1 1 7 7 7 4 HEAT repeats Vac14_Fab1_bd PF12755.2 EFE42501.1 - 0.0014 18.9 0.0 2.1 8.7 0.0 4.8 4 1 0 4 4 4 1 Vacuolar 14 Fab1-binding region DUF2435 PF10363.4 EFE42501.1 - 0.0015 18.3 0.2 0.06 13.2 0.0 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2435) Adaptin_N PF01602.15 EFE42501.1 - 0.0045 15.3 0.0 10 4.3 0.0 4.7 4 1 1 5 5 5 1 Adaptin N terminal region Cnd1 PF12717.2 EFE42501.1 - 0.019 14.8 0.0 0.13 12.0 0.0 2.5 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 DRIM PF07539.7 EFE42501.1 - 0.031 13.6 0.1 0.86 9.0 0.0 2.8 2 0 0 2 2 2 0 Down-regulated in metastasis DUF3295 PF11702.3 EFE42501.1 - 0.07 12.1 0.1 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) TIP120 PF08623.5 EFE42502.1 - 3.2e-58 196.0 0.0 3.6e-58 195.8 0.0 1.0 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) PalH PF08733.5 EFE42504.1 - 7.7e-99 330.8 0.1 4.1e-98 328.4 0.1 1.9 1 1 0 1 1 1 1 PalH/RIM21 Atg14 PF10186.4 EFE42507.1 - 1.2e-19 70.3 0.0 2.3e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 MRFAP1 PF15155.1 EFE42507.1 - 0.21 11.9 2.7 0.37 11.1 1.8 1.4 1 0 0 1 1 1 0 MORF4 family-associated protein1 FUSC PF04632.7 EFE42507.1 - 6.1 5.1 6.3 8.9 4.5 4.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Mhr1 PF12829.2 EFE42508.1 - 3.2e-30 103.8 0.3 8.7e-30 102.4 0.2 1.8 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination Filo_VP35 PF02097.10 EFE42508.1 - 0.19 10.9 1.8 0.28 10.3 1.2 1.2 1 0 0 1 1 1 0 Filoviridae VP35 PP2C PF00481.16 EFE42509.1 - 8.2e-64 215.4 0.0 3.3e-50 170.8 0.0 3.7 2 1 1 3 3 3 3 Protein phosphatase 2C Snf7 PF03357.16 EFE42511.1 - 3.2e-30 104.7 6.4 6.1e-30 103.8 3.6 1.8 2 0 0 2 2 2 1 Snf7 Ist1 PF03398.9 EFE42511.1 - 0.06 12.7 1.4 0.086 12.2 1.0 1.4 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DUF3684 PF12449.3 EFE42511.1 - 0.14 9.6 1.0 0.17 9.4 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) Sugar_tr PF00083.19 EFE42512.1 - 1.3e-105 353.6 19.0 1.6e-105 353.3 13.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE42512.1 - 1.4e-25 89.8 33.5 7.6e-25 87.3 17.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE42512.1 - 6.8e-07 28.0 0.4 6.8e-07 28.0 0.3 3.6 4 0 0 4 4 4 2 MFS/sugar transport protein DUF791 PF05631.9 EFE42512.1 - 6.2e-06 25.1 0.9 1.2e-05 24.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF791) Transglut_core PF01841.14 EFE42513.1 - 6.1e-13 48.9 0.0 1.2e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily EDR1 PF14381.1 EFE42513.1 - 0.23 10.9 0.0 0.35 10.3 0.0 1.2 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 Ras PF00071.17 EFE42514.1 - 3.7e-21 75.1 0.0 6e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE42514.1 - 1.5e-20 73.8 0.0 3.4e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE42514.1 - 9.5e-07 28.2 0.0 1.7e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFE42514.1 - 0.0015 17.7 0.0 0.0015 17.7 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFE42514.1 - 0.0055 16.6 1.1 0.0095 15.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase BaxI_1 PF12811.2 EFE42514.1 - 0.075 12.1 0.7 0.11 11.6 0.5 1.2 1 0 0 1 1 1 0 Bax inhibitor 1 like BAF1_ABF1 PF04684.8 EFE42514.1 - 4.2 6.0 12.4 6.9 5.3 8.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor G-alpha PF00503.15 EFE42514.1 - 7.2 5.1 10.9 1.7 7.2 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit WD40 PF00400.27 EFE42515.1 - 6.9e-27 92.3 6.3 7.4e-10 38.3 0.1 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 EFE42515.1 - 3.8e-19 68.3 0.0 7.8e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex Nup160 PF11715.3 EFE42515.1 - 0.00051 18.3 1.5 0.00083 17.6 0.1 1.8 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Vpu PF00558.14 EFE42515.1 - 0.21 11.1 1.7 0.42 10.2 1.2 1.4 1 0 0 1 1 1 0 Vpu protein Fungal_trans PF04082.13 EFE42517.1 - 5.4e-21 74.6 1.2 1.2e-20 73.4 0.8 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EFE42517.1 - 1.3e-09 37.7 13.9 4.6e-05 23.5 1.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFE42517.1 - 5.6e-06 26.3 6.9 5.6e-06 26.3 4.8 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFE42517.1 - 0.0011 19.1 14.6 0.11 12.9 1.9 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger PX PF00787.19 EFE42520.1 - 3.4e-16 59.0 0.2 8.9e-16 57.6 0.1 1.8 1 0 0 1 1 1 1 PX domain AAA PF00004.24 EFE42520.1 - 6e-08 32.9 0.7 4e-07 30.3 0.5 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE42520.1 - 0.00038 21.2 0.0 0.0015 19.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE42520.1 - 0.0011 18.6 0.0 0.0029 17.3 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 EFE42520.1 - 0.0061 16.5 1.7 0.061 13.3 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain Rad17 PF03215.10 EFE42520.1 - 0.013 14.1 0.3 0.17 10.5 0.0 2.5 2 1 0 2 2 2 0 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 EFE42520.1 - 0.014 14.4 0.1 0.038 13.0 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFE42520.1 - 0.043 13.9 0.4 0.28 11.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain TIP49 PF06068.8 EFE42520.1 - 0.046 12.4 0.0 0.076 11.7 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_33 PF13671.1 EFE42520.1 - 0.056 13.3 0.8 0.35 10.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain Nha1_C PF08619.5 EFE42521.1 - 5.6e-72 243.3 10.7 9.9e-72 242.5 7.4 1.4 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.16 EFE42521.1 - 1e-63 215.1 19.4 1.2e-63 214.8 13.4 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.1 EFE42521.1 - 0.13 12.2 3.2 0.22 11.4 0.3 2.6 2 0 0 2 2 2 0 YrhC-like protein DUF21 PF01595.15 EFE42521.1 - 5.1 6.3 8.2 0.58 9.4 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF21 SAM_2 PF07647.12 EFE42522.1 - 3.8e-15 55.4 0.0 6.3e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 EFE42522.1 - 5.7e-15 55.5 0.0 1.3e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.25 EFE42522.1 - 3.1e-11 43.2 0.0 4.7e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EnY2 PF10163.4 EFE42523.1 - 0.00013 21.7 0.0 0.00027 20.7 0.0 1.5 1 0 0 1 1 1 1 Transcription factor e(y)2 AAA PF00004.24 EFE42524.1 - 7.3e-97 320.6 0.0 1.3e-47 161.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 EFE42524.1 - 7.1e-20 70.7 0.6 2.5e-19 69.0 0.4 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 EFE42524.1 - 4e-14 52.8 0.0 1e-07 31.9 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EFE42524.1 - 5.8e-13 48.4 0.0 1.9e-05 23.8 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EFE42524.1 - 9.8e-13 48.1 0.0 1e-05 25.4 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 EFE42524.1 - 5.5e-11 43.3 0.0 0.0008 20.2 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFE42524.1 - 5.7e-11 42.6 0.3 0.004 17.3 0.0 4.3 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EFE42524.1 - 8.8e-11 41.6 0.9 1.5e-05 24.7 0.1 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFE42524.1 - 5.4e-10 39.5 0.0 0.00096 19.1 0.0 3.6 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.8 EFE42524.1 - 8.8e-09 34.5 0.1 0.0012 17.6 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus IstB_IS21 PF01695.12 EFE42524.1 - 4.7e-08 32.6 0.0 0.0054 16.1 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.1 EFE42524.1 - 4.9e-08 32.6 5.5 0.021 14.2 0.0 4.8 3 2 2 5 5 4 2 AAA domain CDC48_2 PF02933.12 EFE42524.1 - 2e-07 30.5 0.0 4.9e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_19 PF13245.1 EFE42524.1 - 2.2e-07 30.5 1.6 0.0053 16.4 0.0 2.9 2 0 0 2 2 2 2 Part of AAA domain AAA_14 PF13173.1 EFE42524.1 - 2.6e-07 30.5 0.0 0.0081 16.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 EFE42524.1 - 3.2e-07 29.6 0.0 0.0071 15.4 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin Mg_chelatase PF01078.16 EFE42524.1 - 4.7e-07 29.1 0.4 0.031 13.4 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI KaiC PF06745.8 EFE42524.1 - 1.8e-06 27.2 1.3 0.61 9.1 0.0 3.5 2 1 1 3 3 3 2 KaiC RNA_helicase PF00910.17 EFE42524.1 - 1.9e-06 27.9 0.0 0.026 14.6 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.1 EFE42524.1 - 3e-06 27.5 0.0 0.075 13.3 0.0 3.0 3 0 0 3 3 2 2 AAA domain ResIII PF04851.10 EFE42524.1 - 4.1e-06 26.7 0.0 0.0054 16.5 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_28 PF13521.1 EFE42524.1 - 1.1e-05 25.4 0.0 0.2 11.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.8 EFE42524.1 - 2.3e-05 23.4 0.0 0.0068 15.3 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.22 EFE42524.1 - 5.5e-05 23.4 0.0 0.25 11.6 0.0 3.4 2 1 0 2 2 2 1 ABC transporter PhoH PF02562.11 EFE42524.1 - 5.5e-05 22.4 0.4 0.25 10.5 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_24 PF13479.1 EFE42524.1 - 7.6e-05 22.3 0.5 0.16 11.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.21 EFE42524.1 - 7.8e-05 22.2 0.1 0.63 9.4 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 EFE42524.1 - 7.8e-05 22.7 0.0 0.36 10.8 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.12 EFE42524.1 - 0.00011 21.1 0.1 0.094 11.5 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 EFE42524.1 - 0.0002 21.1 0.1 8.3 6.0 0.0 3.9 2 2 2 4 4 4 0 Archaeal ATPase Vps4_C PF09336.5 EFE42524.1 - 0.00045 20.0 0.2 0.0021 17.8 0.1 2.2 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain Bac_DnaA PF00308.13 EFE42524.1 - 0.00052 19.7 0.0 1.6 8.3 0.0 2.9 3 0 0 3 3 2 2 Bacterial dnaA protein AAA_3 PF07726.6 EFE42524.1 - 0.00066 19.2 0.0 1.5 8.4 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 EFE42524.1 - 0.00078 19.0 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EFE42524.1 - 0.00087 18.9 0.1 0.86 9.2 0.0 3.5 3 1 1 4 4 3 1 NACHT domain DUF2075 PF09848.4 EFE42524.1 - 0.0016 17.4 0.0 0.65 8.9 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 EFE42524.1 - 0.0017 17.9 0.0 1.5 8.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 EFE42524.1 - 0.0037 16.9 1.3 1.2 8.8 0.0 4.1 5 0 0 5 5 3 1 NTPase Viral_helicase1 PF01443.13 EFE42524.1 - 0.0084 15.6 0.0 0.62 9.5 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.17 EFE42524.1 - 0.0097 14.7 1.5 0.67 8.7 0.0 3.0 4 0 0 4 4 4 1 NB-ARC domain LXG PF04740.7 EFE42524.1 - 0.011 15.4 0.1 0.026 14.3 0.1 1.5 1 0 0 1 1 1 0 LXG domain of WXG superfamily KAP_NTPase PF07693.9 EFE42524.1 - 0.021 13.8 0.0 0.92 8.4 0.0 2.7 2 1 1 3 3 3 0 KAP family P-loop domain T2SE PF00437.15 EFE42524.1 - 0.022 13.6 0.0 1.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein IPT PF01745.11 EFE42524.1 - 0.029 13.5 0.1 2.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Cytidylate_kin2 PF13189.1 EFE42524.1 - 0.087 12.7 1.0 5.9 6.7 0.0 3.2 3 0 0 3 3 3 0 Cytidylate kinase-like family AAA_10 PF12846.2 EFE42524.1 - 0.091 12.1 1.1 11 5.2 0.0 3.6 3 1 1 4 4 4 0 AAA-like domain eIF-1a PF01176.14 EFE42524.1 - 0.11 11.9 0.4 1.1 8.6 0.1 2.6 1 1 1 2 2 2 0 Translation initiation factor 1A / IF-1 Zot PF05707.7 EFE42524.1 - 0.13 11.7 0.1 30 4.0 0.1 3.6 3 1 0 3 3 3 0 Zonular occludens toxin (Zot) KTI12 PF08433.5 EFE42524.1 - 0.14 11.3 0.0 22 4.1 0.0 2.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 UPF0079 PF02367.12 EFE42524.1 - 0.17 11.5 0.1 12 5.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AIG2 PF06094.7 EFE42525.1 - 2.9e-06 27.6 0.0 8.7e-06 26.1 0.0 1.7 2 0 0 2 2 2 1 AIG2-like family PTP_N PF12453.3 EFE42525.1 - 0.15 11.7 0.1 0.15 11.7 0.1 1.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase N terminal PsiF_repeat PF07769.9 EFE42528.1 - 0.059 12.9 0.1 0.18 11.3 0.0 1.8 1 0 0 1 1 1 0 psiF repeat PEX11 PF05648.9 EFE42529.1 - 5e-17 61.9 0.9 1.7e-15 56.8 0.1 2.0 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Mpv17_PMP22 PF04117.7 EFE42531.1 - 2e-10 40.1 6.9 2e-09 36.9 0.3 3.2 3 0 0 3 3 3 2 Mpv17 / PMP22 family SprT-like PF10263.4 EFE42532.1 - 9.7e-08 31.8 0.5 9.7e-08 31.8 0.3 2.0 2 0 0 2 2 2 1 SprT-like family Cullin_binding PF03556.10 EFE42533.1 - 4.8e-30 104.0 2.1 7.1e-30 103.5 1.4 1.2 1 0 0 1 1 1 1 Cullin binding NOC3p PF07540.6 EFE42534.1 - 5.2e-33 113.1 0.3 5e-32 110.0 0.2 2.5 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.12 EFE42534.1 - 1.2e-30 106.0 0.0 8.2e-28 96.9 0.0 2.4 1 1 1 2 2 2 2 CBF/Mak21 family Adaptin_N PF01602.15 EFE42534.1 - 0.0089 14.3 1.6 4.9 5.3 0.0 3.1 3 0 0 3 3 3 2 Adaptin N terminal region Cnd3 PF12719.2 EFE42534.1 - 0.024 13.6 0.1 0.054 12.4 0.0 1.6 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain UBN2 PF14223.1 EFE42535.1 - 0.015 15.1 0.2 2 8.2 0.0 2.2 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type DUF1349 PF07081.6 EFE42538.1 - 1.9e-19 69.7 0.0 6.3e-08 32.1 0.0 3.2 3 1 0 3 3 3 2 Protein of unknown function (DUF1349) MRP-L46 PF11788.3 EFE42539.1 - 2.5e-35 121.4 0.2 4.1e-35 120.8 0.2 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.23 EFE42539.1 - 0.0042 16.7 0.0 0.0094 15.5 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain HLH PF00010.21 EFE42540.1 - 2.8e-12 46.1 0.0 8.4e-12 44.5 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mito_carr PF00153.22 EFE42541.1 - 1.2e-42 143.5 0.2 5.5e-21 74.0 0.0 2.4 3 0 0 3 3 3 2 Mitochondrial carrier protein Dna2 PF08696.6 EFE42542.1 - 1.1e-69 233.8 0.0 1.9e-69 233.1 0.0 1.3 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.1 EFE42542.1 - 1.1e-52 178.3 0.0 1.9e-52 177.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EFE42542.1 - 2.9e-41 141.5 0.1 2.3e-21 76.4 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.1 EFE42542.1 - 1.5e-13 50.7 0.0 3.3e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain PDDEXK_1 PF12705.2 EFE42542.1 - 8.9e-12 44.9 0.0 2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily AAA_19 PF13245.1 EFE42542.1 - 2.6e-10 39.8 0.2 7.4e-10 38.4 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain Cas_Cas4 PF01930.12 EFE42542.1 - 1e-08 35.2 0.0 3.9e-06 26.8 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.13 EFE42542.1 - 5.9e-07 29.2 0.3 0.18 11.3 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.9 EFE42542.1 - 6.4e-05 22.6 0.0 0.00016 21.3 0.0 1.7 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.16 EFE42542.1 - 0.00047 19.5 0.7 0.0012 18.2 0.1 1.9 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.17 EFE42542.1 - 0.00081 18.8 0.2 0.0016 17.9 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MobB PF03205.9 EFE42542.1 - 0.0019 17.9 0.0 0.0045 16.7 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.18 EFE42542.1 - 0.0024 17.3 0.0 0.0052 16.2 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.1 EFE42542.1 - 0.0027 17.1 0.0 0.0062 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 EFE42542.1 - 0.0036 17.7 0.0 0.0084 16.6 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 EFE42542.1 - 0.0057 16.6 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.4 EFE42542.1 - 0.0064 15.5 0.0 0.011 14.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.9 EFE42542.1 - 0.014 14.3 0.2 0.043 12.7 0.1 1.8 1 1 0 1 1 1 0 PIF1-like helicase AAA PF00004.24 EFE42542.1 - 0.038 14.2 0.1 0.18 11.9 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.12 EFE42542.1 - 0.046 13.5 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF87 NTPase_1 PF03266.10 EFE42542.1 - 0.09 12.4 0.2 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 NTPase AAA_33 PF13671.1 EFE42542.1 - 0.095 12.5 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFE42542.1 - 0.097 12.1 0.1 0.3 10.5 0.0 1.8 2 0 0 2 2 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 EFE42542.1 - 0.099 12.7 0.1 0.34 11.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFE42542.1 - 0.15 11.7 0.0 0.41 10.3 0.0 1.7 2 0 0 2 2 1 0 Archaeal ATPase ArgK PF03308.11 EFE42542.1 - 0.16 10.7 0.1 0.32 9.7 0.0 1.4 1 0 0 1 1 1 0 ArgK protein Ribonuc_P_40 PF08584.6 EFE42543.1 - 5.1e-63 212.7 0.0 4.3e-61 206.4 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit WD40 PF00400.27 EFE42544.1 - 7.3e-36 120.7 13.2 5.3e-09 35.6 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 EFE42544.1 - 4.8e-07 28.4 0.0 0.0036 15.6 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.6 EFE42544.1 - 0.00056 19.6 0.0 1.3 8.7 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 EFE42544.1 - 0.017 13.2 0.1 1.3 7.0 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DPPIV_N PF00930.16 EFE42544.1 - 0.06 11.9 0.0 0.21 10.1 0.0 1.9 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.7 EFE42544.1 - 0.061 13.0 2.8 10 5.9 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Fungal_trans PF04082.13 EFE42545.1 - 1.7e-19 69.6 0.1 3.4e-19 68.7 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE42545.1 - 7.1e-10 38.6 9.6 1.6e-09 37.5 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L2_C PF03947.13 EFE42546.1 - 4.2e-45 152.7 2.9 7.2e-34 116.3 1.1 2.5 2 0 0 2 2 2 2 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EFE42546.1 - 6.5e-25 86.8 0.5 1.2e-24 85.9 0.3 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Cyclin_N PF00134.18 EFE42547.1 - 1.8e-46 156.8 0.1 4.3e-44 149.1 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFE42547.1 - 6.7e-31 106.6 0.0 1.4e-30 105.6 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Peptidase_S64 PF08192.6 EFE42547.1 - 2.7 6.2 10.9 0.97 7.6 5.5 1.6 1 1 1 2 2 2 0 Peptidase family S64 UPF0020 PF01170.13 EFE42548.1 - 3.2e-12 46.3 0.0 5.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 EFE42548.1 - 2.7e-09 37.0 0.0 2.3e-08 34.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain N6_Mtase PF02384.11 EFE42548.1 - 3.2e-05 23.1 0.0 4.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase MethyltransfD12 PF02086.10 EFE42548.1 - 0.041 13.3 0.0 0.14 11.5 0.0 1.9 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Uma2 PF05685.7 EFE42549.1 - 0.00063 19.1 0.1 0.00091 18.6 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease DUF2985 PF11204.3 EFE42550.1 - 1.7e-14 53.3 10.1 2.3e-09 36.8 0.1 3.0 2 1 1 3 3 3 2 Protein of unknown function (DUF2985) LTXXQ PF07813.7 EFE42550.1 - 0.0004 20.7 0.2 0.0004 20.7 0.2 2.4 2 0 0 2 2 2 1 LTXXQ motif family protein LMBR1 PF04791.11 EFE42550.1 - 0.036 12.6 0.9 0.07 11.7 0.0 1.8 1 1 0 2 2 2 0 LMBR1-like membrane protein Peptidase_S49_N PF08496.5 EFE42550.1 - 0.25 11.1 8.6 0.96 9.2 3.5 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal BLVR PF06375.6 EFE42550.1 - 9.1 6.0 18.5 0.067 13.0 5.5 2.5 3 0 0 3 3 3 0 Bovine leukaemia virus receptor (BLVR) Kdo PF06293.9 EFE42551.1 - 0.00046 19.3 0.0 0.001 18.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EFE42551.1 - 0.00086 18.5 0.0 0.0019 17.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFE42551.1 - 0.0034 17.1 0.1 0.0034 17.1 0.0 3.0 2 1 0 3 3 3 1 Phosphotransferase enzyme family FemAB PF02388.11 EFE42551.1 - 0.06 12.0 2.1 0.098 11.3 1.5 1.2 1 0 0 1 1 1 0 FemAB family DUF2514 PF10721.4 EFE42551.1 - 0.09 12.4 20.4 0.2 11.3 14.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Pex14_N PF04695.8 EFE42551.1 - 0.11 12.5 10.5 0.27 11.2 0.6 3.6 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4337 PF14235.1 EFE42551.1 - 2.7 7.8 10.6 6.2 6.6 7.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Borrelia_P83 PF05262.6 EFE42551.1 - 7.1 4.7 13.5 14 3.8 9.3 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein SIR2 PF02146.12 EFE42552.1 - 3.3e-60 202.8 0.0 4.8e-60 202.3 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.8 EFE42552.1 - 1.1e-05 24.9 0.0 2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 EFE42552.1 - 0.002 17.8 0.2 0.97 9.1 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Ribosomal_L34e PF01199.13 EFE42552.1 - 0.097 12.9 1.5 0.19 11.9 1.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L34e TPR_2 PF07719.12 EFE42553.1 - 6.9e-13 47.4 0.0 7e-05 22.4 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFE42553.1 - 1.2e-12 47.5 0.0 6.4e-08 32.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE42553.1 - 5.1e-12 45.2 0.0 3e-07 29.9 0.0 3.8 3 1 1 4 4 4 2 TPR repeat TPR_19 PF14559.1 EFE42553.1 - 1.2e-11 44.7 0.2 5.8e-06 26.5 0.0 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFE42553.1 - 8.1e-10 38.4 1.2 0.066 13.8 0.0 5.5 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFE42553.1 - 9.4e-09 34.5 0.0 0.00026 20.4 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE42553.1 - 8.8e-08 32.6 0.0 0.0025 18.4 0.0 4.4 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFE42553.1 - 6.2e-07 28.7 0.0 1.7e-05 24.2 0.0 3.2 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 EFE42553.1 - 1.1e-06 28.4 0.2 7.3 6.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE42553.1 - 8.6e-05 22.0 0.0 0.013 15.2 0.0 4.0 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFE42553.1 - 0.00017 21.3 0.5 0.11 12.4 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 EFE42553.1 - 0.00018 21.5 0.0 0.024 14.7 0.0 3.1 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 EFE42553.1 - 0.0051 16.8 0.0 24 5.4 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.4 EFE42553.1 - 0.015 15.2 0.0 0.79 9.6 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 EFE42553.1 - 0.021 14.0 0.6 1.4 8.2 0.0 2.6 2 0 0 2 2 2 0 SHNi-TPR TPR_4 PF07721.9 EFE42553.1 - 0.039 14.3 0.3 1.6 9.4 0.0 3.3 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_5 PF12688.2 EFE42553.1 - 0.11 12.4 0.0 0.4 10.7 0.0 2.0 1 0 0 1 1 1 0 Tetratrico peptide repeat C_GCAxxG_C_C PF09719.5 EFE42553.1 - 0.15 11.8 0.0 0.58 9.9 0.0 1.9 2 0 0 2 2 2 0 Putative redox-active protein (C_GCAxxG_C_C) RWD PF05773.17 EFE42554.1 - 1.3e-25 89.5 0.6 1.3e-25 89.5 0.4 1.5 2 0 0 2 2 2 1 RWD domain DUF1485 PF07364.7 EFE42554.1 - 0.0019 17.4 0.0 0.02 14.1 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1485) RNase_H2-Ydr279 PF09468.5 EFE42554.1 - 0.011 15.0 1.2 0.011 14.9 0.9 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) APG6 PF04111.7 EFE42554.1 - 3.2 6.7 9.3 5 6.0 6.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Pyridox_oxidase PF01243.15 EFE42555.1 - 5e-05 23.2 0.0 0.0001 22.2 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase GST_C PF00043.20 EFE42556.1 - 3.3e-17 62.2 0.1 5.8e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFE42556.1 - 2e-14 53.5 0.0 3.8e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 EFE42556.1 - 1.5e-11 44.2 0.0 2.7e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE42556.1 - 5.6e-11 42.2 0.0 1.2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE42556.1 - 3.8e-09 36.3 0.4 1.4e-08 34.4 0.1 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE42556.1 - 7.2e-05 23.1 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain YflT PF11181.3 EFE42557.1 - 0.049 13.7 0.2 0.081 13.0 0.1 1.4 1 0 0 1 1 1 0 Heat induced stress protein YflT Sec7_N PF12783.2 EFE42558.1 - 1.7e-39 134.9 6.0 1.7e-39 134.9 4.2 4.0 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 EFE42558.1 - 0.00052 19.4 2.7 0.007 15.8 0.0 4.3 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Antimicrobial19 PF08225.6 EFE42558.1 - 0.12 11.8 0.4 0.38 10.1 0.0 2.1 2 0 0 2 2 2 0 Pseudin antimicrobial peptide Vps26 PF03643.10 EFE42559.1 - 2.9e-112 373.9 0.4 2.2e-103 344.8 0.1 2.1 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 EFE42559.1 - 0.0038 17.0 0.6 3.4 7.4 0.0 3.0 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain DUF432 PF04254.8 EFE42559.1 - 0.059 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF432) AAA_33 PF13671.1 EFE42560.1 - 1.7e-12 47.4 0.0 6.1e-12 45.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFE42560.1 - 8.9e-12 45.4 0.0 1.9e-11 44.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE42560.1 - 3.4e-11 44.0 0.0 4.8e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 EFE42560.1 - 6.5e-11 42.3 0.0 2.5e-10 40.4 0.0 1.9 1 1 0 1 1 1 1 Shikimate kinase Rad17 PF03215.10 EFE42560.1 - 2.7e-06 26.3 0.0 3.9e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA PF00004.24 EFE42560.1 - 4.6e-05 23.6 0.0 8.4e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EFE42560.1 - 5.2e-05 23.1 0.0 0.00014 21.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFE42560.1 - 9.5e-05 22.5 0.1 0.00027 21.0 0.0 1.9 1 1 1 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.1 EFE42560.1 - 9.8e-05 22.3 0.0 0.0033 17.3 0.0 2.2 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_19 PF13245.1 EFE42560.1 - 0.00045 19.9 0.0 0.0011 18.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 EFE42560.1 - 0.00068 19.3 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.17 EFE42560.1 - 0.0013 18.9 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.1 EFE42560.1 - 0.0016 18.4 0.0 0.0036 17.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 EFE42560.1 - 0.0047 16.5 0.0 0.015 14.9 0.0 1.8 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA_16 PF13191.1 EFE42560.1 - 0.0068 16.4 0.1 0.04 13.9 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain tRNA_lig_kinase PF08303.6 EFE42560.1 - 0.012 15.4 0.0 0.029 14.2 0.0 1.6 2 0 0 2 2 2 0 tRNA ligase kinase domain ABC_tran PF00005.22 EFE42560.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.1 EFE42560.1 - 0.017 14.6 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EFE42560.1 - 0.017 14.4 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 EFE42560.1 - 0.017 13.9 0.0 0.031 13.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Arch_ATPase PF01637.13 EFE42560.1 - 0.019 14.6 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase PhoH PF02562.11 EFE42560.1 - 0.019 14.2 0.1 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.4 EFE42560.1 - 0.021 13.8 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PRK PF00485.13 EFE42560.1 - 0.022 14.3 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.7 EFE42560.1 - 0.023 13.7 0.0 0.041 12.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Viral_helicase1 PF01443.13 EFE42560.1 - 0.025 14.0 0.0 0.056 12.9 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase UPF0079 PF02367.12 EFE42560.1 - 0.027 14.1 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 EFE42560.1 - 0.033 13.7 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Herpes_Helicase PF02689.9 EFE42560.1 - 0.035 11.8 0.1 0.048 11.4 0.0 1.1 1 0 0 1 1 1 0 Helicase NTPase_1 PF03266.10 EFE42560.1 - 0.043 13.5 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.16 EFE42560.1 - 0.052 12.7 0.1 0.12 11.4 0.0 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI ADK PF00406.17 EFE42560.1 - 0.056 13.3 0.1 0.95 9.3 0.0 2.1 2 0 0 2 2 2 0 Adenylate kinase AAA_5 PF07728.9 EFE42560.1 - 0.058 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CoaE PF01121.15 EFE42560.1 - 0.058 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase RuvB_N PF05496.7 EFE42560.1 - 0.063 12.3 0.0 0.094 11.7 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus PduV-EutP PF10662.4 EFE42560.1 - 0.078 12.4 0.0 0.45 9.9 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Acetyltransf_3 PF13302.1 EFE42561.1 - 1.4e-16 60.9 0.0 1.7e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Peptidase_C14 PF00656.17 EFE42562.1 - 9e-61 205.6 0.0 1.2e-60 205.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain 2-oxoacid_dh PF00198.18 EFE42563.1 - 2.8e-81 272.1 0.9 3.8e-81 271.7 0.6 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.12 EFE42563.1 - 2.1e-14 52.8 0.8 3.8e-14 52.0 0.0 1.9 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl PF00364.17 EFE42563.1 - 3.7e-12 45.7 0.0 8.9e-12 44.4 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme DUF3597 PF12200.3 EFE42563.1 - 0.5 10.7 5.5 0.7 10.2 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) RuBisCO_large_N PF02788.11 EFE42563.1 - 3.5 7.3 5.0 7.7 6.2 3.4 1.5 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain PI-PLC-X PF00388.14 EFE42564.1 - 5.6e-14 51.7 0.0 1e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Ribosomal_L10 PF00466.15 EFE42565.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L10 Auxin_repressed PF05564.7 EFE42565.1 - 0.11 13.1 0.3 0.23 12.0 0.2 1.5 1 0 0 1 1 1 0 Dormancy/auxin associated protein F-box PF00646.28 EFE42566.1 - 0.081 12.6 0.3 0.32 10.6 0.1 2.0 2 0 0 2 2 2 0 F-box domain ocr PF08684.5 EFE42567.1 - 0.13 12.3 0.4 8.3 6.5 0.0 2.3 2 1 0 2 2 2 0 DNA mimic ocr Lipase_GDSL_2 PF13472.1 EFE42568.1 - 1.6e-08 34.8 0.5 7.3e-08 32.7 0.1 2.2 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFE42568.1 - 3.8e-08 33.4 0.0 1.1e-07 31.9 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CoA_binding_2 PF13380.1 EFE42568.1 - 0.063 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 CoA binding domain Hexokinase_2 PF03727.11 EFE42570.1 - 8.1e-27 93.9 0.0 2.1e-22 79.5 0.0 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.16 EFE42570.1 - 3.1e-26 91.9 0.0 3.9e-23 81.8 0.0 3.1 1 1 0 1 1 1 1 Hexokinase GILT PF03227.11 EFE42571.1 - 7.3e-10 38.6 0.5 7.3e-10 38.6 0.4 2.4 1 1 2 3 3 3 1 Gamma interferon inducible lysosomal thiol reductase (GILT) E3_UbLigase_R4 PF13764.1 EFE42572.1 - 0.03 12.2 0.1 0.04 11.8 0.1 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 MFS_1 PF07690.11 EFE42573.1 - 1.8e-32 112.4 25.2 1.8e-32 112.4 17.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Spc97_Spc98 PF04130.8 EFE42574.1 - 4.3e-76 256.3 0.0 6.7e-76 255.7 0.0 1.3 1 0 0 1 1 1 1 Spc97 / Spc98 family ThiF PF00899.16 EFE42575.1 - 6.5e-52 174.9 0.0 4.9e-32 110.5 0.0 2.4 2 0 0 2 2 2 2 ThiF family UBACT PF02134.16 EFE42575.1 - 1.4e-39 133.4 4.8 2.2e-26 91.2 0.3 2.6 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_C PF09358.5 EFE42575.1 - 3e-37 127.5 0.0 6.6e-37 126.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UBA_e1_thiolCys PF10585.4 EFE42575.1 - 4e-25 86.9 1.6 2.5e-21 74.7 0.2 2.4 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site GST_N_2 PF13409.1 EFE42576.1 - 4.8e-22 77.7 0.0 1.6e-21 76.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE42576.1 - 2.1e-12 46.7 0.0 4.3e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFE42576.1 - 2e-06 27.9 0.1 9.9e-05 22.4 0.1 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE42576.1 - 2.5e-05 24.1 0.0 7.7e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE42576.1 - 0.0088 16.5 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain EF-hand_7 PF13499.1 EFE42577.1 - 3.8e-23 81.3 4.9 1.3e-13 50.9 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 EFE42577.1 - 3.9e-20 69.5 3.4 1.4e-05 24.0 0.1 4.3 4 0 0 4 4 4 4 EF hand Mito_carr PF00153.22 EFE42577.1 - 1.7e-18 66.0 0.4 4.1e-18 64.8 0.3 1.6 1 1 0 1 1 1 1 Mitochondrial carrier protein EF-hand_5 PF13202.1 EFE42577.1 - 1e-16 59.4 3.0 1.1e-05 24.5 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 EFE42577.1 - 9.2e-15 53.1 6.5 0.0001 21.8 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 EFE42577.1 - 3.7e-14 52.0 2.9 8.3e-06 25.3 0.1 3.4 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 EFE42577.1 - 2.1e-10 40.6 0.3 3.6e-06 26.9 0.1 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 EFE42577.1 - 0.00026 20.6 3.0 0.061 13.0 0.2 3.1 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 EFE42577.1 - 0.00042 19.9 0.1 1 9.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 EFE42578.1 - 0.032 13.5 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 EFE42578.1 - 0.052 13.6 0.2 0.075 13.1 0.1 1.2 1 0 0 1 1 1 0 EF-hand domain pair Cyclin_N PF00134.18 EFE42579.1 - 4.6e-11 42.3 0.3 9.6e-11 41.3 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF4452 PF14618.1 EFE42580.1 - 4e-63 212.1 5.4 4e-63 212.1 3.8 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4452) Macoilin PF09726.4 EFE42580.1 - 0.038 12.2 9.0 0.043 12.1 6.2 1.2 1 0 0 1 1 1 0 Transmembrane protein CDK5_activator PF03261.10 EFE42580.1 - 0.69 9.1 7.8 1.3 8.2 5.4 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein FAM60A PF15396.1 EFE42580.1 - 1.8 8.2 6.8 3 7.5 4.7 1.4 1 0 0 1 1 1 0 Protein Family FAM60A SR-25 PF10500.4 EFE42580.1 - 3.9 6.8 14.9 0.35 10.2 5.2 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Hid1 PF12722.2 EFE42580.1 - 8 4.0 6.8 9.9 3.6 4.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AMP-binding_C_2 PF14535.1 EFE42582.1 - 0.084 12.9 1.4 0.11 12.4 0.9 1.2 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain FDF PF09532.5 EFE42582.1 - 1.4 9.4 7.6 1.7 9.2 5.3 1.1 1 0 0 1 1 1 0 FDF domain zf-met2 PF12907.2 EFE42583.1 - 0.0013 18.6 0.1 0.0027 17.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding Chal_sti_synt_C PF02797.10 EFE42584.1 - 2.3e-18 66.5 0.0 4.1e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.14 EFE42584.1 - 1.7e-16 60.1 0.1 2.8e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III_C PF08541.5 EFE42584.1 - 9e-06 25.6 0.0 0.00012 22.0 0.0 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal FAE1_CUT1_RppA PF08392.7 EFE42584.1 - 0.13 11.3 0.1 0.22 10.5 0.0 1.4 1 1 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein MFS_1 PF07690.11 EFE42585.1 - 1.3e-27 96.4 43.7 2e-26 92.5 16.4 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE42585.1 - 4.8e-06 25.4 5.5 4.8e-06 25.4 3.8 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFE42585.1 - 0.00036 18.8 1.4 0.00081 17.7 1.0 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 EFE42585.1 - 0.0028 15.8 1.3 0.0055 14.8 0.9 1.5 1 0 0 1 1 1 1 Transmembrane secretion effector DUF456 PF04306.8 EFE42585.1 - 0.023 14.7 3.0 0.023 14.7 2.1 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF456) SNARE PF05739.14 EFE42586.1 - 2.6e-15 55.8 2.2 5.1e-15 54.9 0.9 1.9 2 0 0 2 2 2 1 SNARE domain Not3 PF04065.10 EFE42586.1 - 0.041 13.1 0.9 1.4 8.1 0.2 2.1 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Syntaxin PF00804.20 EFE42586.1 - 0.041 14.0 1.0 0.52 10.4 0.1 2.4 2 0 0 2 2 2 0 Syntaxin Spectrin PF00435.16 EFE42586.1 - 0.044 14.0 0.8 0.21 11.8 0.0 2.2 2 0 0 2 2 2 0 Spectrin repeat Phage_GP20 PF06810.6 EFE42586.1 - 0.2 11.0 1.7 1.3 8.4 0.1 2.3 2 1 1 3 3 3 0 Phage minor structural protein GP20 V-SNARE PF05008.10 EFE42586.1 - 1.7 8.8 4.9 0.48 10.6 0.5 2.1 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus zf-TRAF PF02176.13 EFE42587.1 - 8.8e-05 22.8 14.1 0.0013 19.0 3.4 1.7 1 1 1 2 2 2 2 TRAF-type zinc finger Sina PF03145.11 EFE42587.1 - 0.00039 20.1 0.9 0.0012 18.5 0.5 1.8 1 1 1 2 2 2 1 Seven in absentia protein family Fmp27_WPPW PF10359.4 EFE42587.1 - 0.0097 14.3 0.2 0.014 13.8 0.1 1.3 1 1 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain TSC22 PF01166.13 EFE42587.1 - 0.011 15.7 0.6 2.6 8.0 0.1 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family Atg14 PF10186.4 EFE42587.1 - 0.02 13.8 1.0 0.061 12.2 0.0 1.9 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3972 PF13118.1 EFE42587.1 - 0.025 14.6 0.1 0.092 12.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) DivIC PF04977.10 EFE42587.1 - 0.026 14.0 0.1 0.99 8.9 0.0 2.5 3 0 0 3 3 3 0 Septum formation initiator RasGAP_C PF03836.10 EFE42587.1 - 0.052 13.2 0.2 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 RasGAP C-terminus DUF2205 PF10224.4 EFE42587.1 - 0.074 12.6 0.5 7 6.2 0.0 2.5 2 1 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) DUF2730 PF10805.3 EFE42587.1 - 0.092 12.4 3.7 0.62 9.8 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) PspA_IM30 PF04012.7 EFE42587.1 - 0.15 11.3 1.8 6.1 6.1 0.2 2.2 2 0 0 2 2 2 0 PspA/IM30 family TMF_DNA_bd PF12329.3 EFE42587.1 - 0.21 11.4 1.6 1.4 8.8 0.3 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.4 EFE42587.1 - 0.38 10.5 2.2 2.1 8.2 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Het-C PF07217.6 EFE42589.1 - 6.6e-279 926.2 0.0 8.1e-279 925.9 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Defensin_2 PF01097.13 EFE42590.1 - 3.3e-10 39.4 4.6 4.6e-10 39.0 3.2 1.2 1 0 0 1 1 1 1 Arthropod defensin Toxin_38 PF14866.1 EFE42590.1 - 0.00013 21.9 0.3 0.00016 21.7 0.2 1.1 1 0 0 1 1 1 1 Potassium channel toxin BRO1 PF03097.13 EFE42591.1 - 0.042 12.6 0.3 0.044 12.5 0.2 1.2 1 0 0 1 1 1 0 BRO1-like domain Syntaxin PF00804.20 EFE42591.1 - 0.095 12.8 4.0 0.24 11.5 2.8 1.7 1 0 0 1 1 1 0 Syntaxin IncA PF04156.9 EFE42591.1 - 0.21 11.1 3.5 0.32 10.5 2.5 1.3 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 EFE42591.1 - 0.29 10.1 7.4 0.41 9.6 5.1 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF883 PF05957.8 EFE42591.1 - 9.5 6.7 13.0 28 5.2 0.0 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Ank_2 PF12796.2 EFE42592.1 - 1.3e-58 195.2 0.1 2.1e-15 56.8 0.0 8.9 6 2 0 7 7 7 6 Ankyrin repeats (3 copies) Ank PF00023.25 EFE42592.1 - 2e-43 144.0 6.2 2.5e-06 26.9 0.1 12.9 14 0 0 14 14 14 8 Ankyrin repeat Ank_3 PF13606.1 EFE42592.1 - 4.6e-40 131.6 2.4 0.0011 18.9 0.1 13.5 13 0 0 13 13 13 7 Ankyrin repeat Ank_4 PF13637.1 EFE42592.1 - 6.5e-40 134.8 4.4 7.5e-07 29.4 0.0 11.9 9 3 4 13 13 13 8 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE42592.1 - 2.5e-36 122.8 8.1 1.8e-05 24.8 0.0 11.8 11 1 1 12 12 12 6 Ankyrin repeats (many copies) IBN_N PF03810.14 EFE42593.1 - 4e-10 39.4 0.7 1.2e-07 31.5 0.1 3.4 2 1 1 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EFE42593.1 - 1.5e-05 24.9 0.2 0.00068 19.5 0.0 3.4 3 1 0 3 3 3 1 Exportin 1-like protein CAS_CSE1 PF03378.10 EFE42593.1 - 0.0025 16.2 0.1 0.009 14.3 0.0 2.0 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Proteasom_PSMB PF10508.4 EFE42593.1 - 0.045 12.0 0.2 0.23 9.6 0.0 2.1 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit TraG_N PF07916.6 EFE42593.1 - 0.048 12.1 0.0 0.095 11.1 0.0 1.4 1 0 0 1 1 1 0 TraG-like protein, N-terminal region KSR1-SAM PF13543.1 EFE42593.1 - 0.052 13.3 0.3 6.3 6.6 0.0 2.8 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 HORMA PF02301.13 EFE42595.1 - 2.8e-21 75.9 0.0 3.8e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 HORMA domain NAD_binding_2 PF03446.10 EFE42595.1 - 0.06 13.1 0.1 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase IBR PF01485.16 EFE42596.1 - 1.9e-11 43.6 28.6 1.6e-08 34.2 5.6 3.5 3 0 0 3 3 3 3 IBR domain Pkinase PF00069.20 EFE42597.1 - 6.6e-19 68.0 0.0 3e-18 65.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42597.1 - 5.1e-10 38.8 0.0 9.5e-10 37.9 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 EFE42597.1 - 0.017 14.1 0.0 0.28 10.2 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE42597.1 - 0.061 13.0 0.1 0.21 11.2 0.0 1.9 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 EFE42597.1 - 0.17 10.6 0.0 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Acetyltransf_7 PF13508.1 EFE42598.1 - 0.00016 21.7 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE42598.1 - 0.0022 17.8 0.0 0.0054 16.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE42598.1 - 0.011 15.7 0.1 0.036 14.1 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family FR47 PF08445.5 EFE42598.1 - 0.071 12.8 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.1 EFE42598.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Pro_dh PF01619.13 EFE42599.1 - 2.6e-39 135.0 2.9 3.5e-39 134.6 2.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase MAAL_N PF05034.8 EFE42599.1 - 0.063 13.0 0.1 0.68 9.6 0.0 2.2 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase N-terminus Radical_SAM PF04055.16 EFE42600.1 - 1.4e-23 83.8 0.1 2.9e-23 82.8 0.1 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 EFE42600.1 - 3.7e-22 78.1 0.0 1e-21 76.8 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.20 EFE42600.1 - 7.9e-08 32.4 0.6 6.3e-06 26.2 0.4 2.5 1 1 0 1 1 1 1 Flavodoxin MFS_1 PF07690.11 EFE42601.1 - 2.4e-45 154.7 42.7 2.4e-45 154.7 29.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE42601.1 - 0.00048 18.8 31.2 0.0053 15.3 21.6 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter OAR PF03826.12 EFE42604.1 - 3.1 7.4 6.1 3.8 7.1 0.8 2.5 2 0 0 2 2 2 0 OAR domain GWT1 PF06423.7 EFE42605.1 - 1.3e-40 138.6 2.6 1.3e-40 138.6 1.8 2.3 2 0 0 2 2 2 1 GWT1 Amidase PF01425.16 EFE42606.1 - 8.2e-81 272.0 0.2 1.1e-80 271.6 0.1 1.1 1 0 0 1 1 1 1 Amidase Sec63 PF02889.11 EFE42607.1 - 9.9e-47 159.6 0.0 8.4e-45 153.3 0.0 2.2 1 1 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.26 EFE42607.1 - 3.9e-18 64.9 0.4 8.2e-18 63.9 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain 7tm_1 PF00001.16 EFE42607.1 - 0.038 13.1 0.0 0.095 11.8 0.0 1.6 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Peptidase_M24 PF00557.19 EFE42609.1 - 4.1e-52 176.7 0.0 5.4e-52 176.3 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EFE42609.1 - 5.3e-24 84.1 0.0 1.3e-23 82.8 0.0 1.6 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain HATPase_c_2 PF13581.1 EFE42610.1 - 0.078 12.7 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain TRAP_alpha PF03896.11 EFE42610.1 - 0.092 11.7 0.8 0.097 11.6 0.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PBP1_TM PF14812.1 EFE42610.1 - 1.6 9.0 6.1 2.1 8.7 4.2 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoplasmin PF03066.10 EFE42610.1 - 4.6 6.7 9.7 5.7 6.4 6.7 1.1 1 0 0 1 1 1 0 Nucleoplasmin zf-C2H2 PF00096.21 EFE42611.1 - 0.0001 22.3 4.6 0.083 13.2 0.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE42611.1 - 0.00013 22.0 3.4 0.061 13.6 0.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFE42611.1 - 0.085 13.1 0.7 0.25 11.6 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger double domain F-box-like PF12937.2 EFE42612.1 - 0.00033 20.2 0.8 0.0013 18.4 0.0 2.5 2 1 1 3 3 3 1 F-box-like F-box PF00646.28 EFE42612.1 - 0.0032 17.0 0.0 0.012 15.2 0.0 2.0 1 0 0 1 1 1 1 F-box domain Methyltransf_26 PF13659.1 EFE42613.1 - 4.9e-17 62.0 0.0 7e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE42613.1 - 0.00023 20.5 0.4 0.095 12.0 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase small domain Methyltransf_31 PF13847.1 EFE42613.1 - 0.002 17.7 0.0 0.012 15.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE42613.1 - 0.068 13.6 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TauD PF02668.11 EFE42614.1 - 7.7e-24 84.7 0.0 9.9e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_lectin PF07938.7 EFE42615.1 - 4.3e-16 59.0 0.2 5.3e-16 58.7 0.1 1.1 1 0 0 1 1 1 1 Fungal fucose-specific lectin Mito_carr PF00153.22 EFE42616.1 - 1.9e-62 206.9 0.7 1.1e-21 76.3 0.2 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein F-box-like PF12937.2 EFE42617.1 - 2.7e-09 36.6 0.8 7e-09 35.2 0.6 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE42617.1 - 1.9e-06 27.3 0.5 4.4e-06 26.2 0.4 1.6 1 0 0 1 1 1 1 F-box domain APH PF01636.18 EFE42617.1 - 0.008 15.9 0.3 0.022 14.5 0.2 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family Gemini_AL2 PF01440.11 EFE42617.1 - 3.6 7.7 7.8 0.12 12.4 0.7 2.1 2 0 0 2 2 2 0 Geminivirus AL2 protein Striatin PF08232.7 EFE42618.1 - 0.16 12.2 2.8 0.21 11.9 2.0 1.1 1 0 0 1 1 1 0 Striatin family Endonuc_Holl PF10107.4 EFE42618.1 - 0.17 11.5 3.4 0.21 11.2 2.3 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF3306 PF11748.3 EFE42618.1 - 0.22 12.1 10.9 0.31 11.6 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF4355 PF14265.1 EFE42618.1 - 0.23 11.4 11.3 0.26 11.2 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) eIF3_subunit PF08597.5 EFE42618.1 - 0.34 10.4 8.0 0.35 10.3 5.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4139 PF13598.1 EFE42618.1 - 1 8.5 12.4 1.3 8.3 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) Spore_coat_CotO PF14153.1 EFE42618.1 - 1.1 8.6 6.4 1.1 8.6 4.4 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF853 PF05872.7 EFE42618.1 - 1.6 6.9 8.3 1.7 6.8 5.7 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Herpes_UL25 PF01499.11 EFE42618.1 - 2.1 6.5 8.8 2.2 6.4 6.1 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family FYDLN_acid PF09538.5 EFE42618.1 - 3.4 8.2 5.5 4.5 7.9 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CagX PF03524.10 EFE42618.1 - 4.3 6.5 5.2 6 6.0 3.6 1.2 1 0 0 1 1 1 0 Conjugal transfer protein RR_TM4-6 PF06459.7 EFE42618.1 - 4.4 7.1 7.9 4.6 7.0 5.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3597 PF12200.3 EFE42618.1 - 4.5 7.6 8.5 6 7.2 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) Phage_GPD PF05954.6 EFE42618.1 - 8.3 5.5 9.2 11 5.1 6.4 1.3 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) SNF2_N PF00176.18 EFE42619.1 - 2.2e-19 69.4 0.0 4.1e-17 61.9 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain ResIII PF04851.10 EFE42619.1 - 6.2e-05 22.9 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Cullin PF00888.17 EFE42620.1 - 4.2e-47 161.0 0.0 7.6e-47 160.1 0.0 1.3 1 0 0 1 1 1 1 Cullin family APC2 PF08672.6 EFE42620.1 - 9e-22 77.0 0.1 2.3e-21 75.7 0.1 1.8 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Pkr1 PF08636.5 EFE42621.1 - 6e-31 106.3 3.9 1.2e-30 105.3 2.7 1.5 1 0 0 1 1 1 1 ER protein Pkr1 GTP_EFTU PF00009.22 EFE42621.1 - 7.3e-10 38.5 0.0 2.2e-09 37.0 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.22 EFE42621.1 - 0.01 16.1 0.0 0.033 14.4 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 EFE42621.1 - 0.018 15.0 0.1 0.11 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 EFE42621.1 - 0.018 14.5 0.3 0.047 13.2 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFE42621.1 - 0.029 14.6 0.0 0.16 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 EFE42621.1 - 0.043 13.7 0.0 0.099 12.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 EFE42621.1 - 0.058 12.8 0.1 0.11 11.9 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF258 PF03193.11 EFE42621.1 - 0.082 12.0 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ATP_bind_1 PF03029.12 EFE42621.1 - 0.13 11.7 0.1 5.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Hid1 PF12722.2 EFE42622.1 - 0.00025 18.8 6.8 0.00026 18.8 4.7 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Pox_Ag35 PF03286.9 EFE42622.1 - 0.11 12.0 29.5 0.17 11.3 20.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Drc1-Sld2 PF11719.3 EFE42622.1 - 0.11 11.5 29.4 0.13 11.3 20.4 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein SprA-related PF12118.3 EFE42622.1 - 0.16 11.2 25.6 0.2 10.9 17.8 1.1 1 0 0 1 1 1 0 SprA-related family Spore_coat_CotO PF14153.1 EFE42622.1 - 0.3 10.4 32.0 0.53 9.7 22.2 1.4 1 0 0 1 1 1 0 Spore coat protein CotO DUF1510 PF07423.6 EFE42622.1 - 0.53 9.6 36.6 0.88 8.8 25.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Daxx PF03344.10 EFE42622.1 - 0.72 8.2 36.4 0.9 7.9 25.2 1.0 1 0 0 1 1 1 0 Daxx Family CAF-1_p150 PF11600.3 EFE42622.1 - 0.77 9.0 63.9 1 8.6 44.3 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ycf1 PF05758.7 EFE42622.1 - 1.1 6.9 23.1 1.4 6.5 16.0 1.1 1 0 0 1 1 1 0 Ycf1 MIP-T3 PF10243.4 EFE42622.1 - 1.6 7.1 56.3 2 6.8 39.0 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Trypan_PARP PF05887.6 EFE42622.1 - 1.8 8.3 29.1 2.8 7.7 20.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NPR3 PF03666.8 EFE42622.1 - 4.3 5.7 23.1 5.6 5.3 16.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.7 EFE42622.1 - 6.2 6.6 34.7 10 5.9 24.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPP4R2 PF09184.6 EFE42622.1 - 8 5.9 28.7 11 5.4 19.9 1.2 1 0 0 1 1 1 0 PPP4R2 RUN PF02759.14 EFE42623.1 - 0.048 13.4 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 RUN domain Arf PF00025.16 EFE42626.1 - 2.5e-74 248.2 1.5 1.1e-73 246.1 1.1 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFE42626.1 - 4.6e-13 48.7 0.0 6.1e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 EFE42626.1 - 1.1e-11 44.4 0.0 1.4e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EFE42626.1 - 1.3e-11 43.8 1.9 1.1e-08 34.1 0.3 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 EFE42626.1 - 8.3e-09 34.9 0.0 1.2e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EFE42626.1 - 2.6e-08 34.3 0.0 3.6e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFE42626.1 - 2.5e-06 27.4 0.1 3.4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFE42626.1 - 0.00053 19.4 0.0 0.00065 19.1 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 EFE42626.1 - 0.019 14.8 0.3 0.061 13.1 0.2 2.0 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.13 EFE42626.1 - 0.055 12.5 0.4 0.1 11.6 0.3 1.6 1 1 0 1 1 1 0 6-phosphofructo-2-kinase Acetyltransf_1 PF00583.19 EFE42627.1 - 4e-12 46.0 0.0 6.7e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFE42627.1 - 3.5e-09 36.7 0.0 2.1e-07 31.0 0.0 2.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE42627.1 - 4.6e-07 29.5 0.0 1.8e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.1 EFE42627.1 - 4e-05 23.6 0.0 6.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFE42627.1 - 0.00027 21.0 0.0 0.00046 20.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE42627.1 - 0.02 14.7 0.1 0.075 12.8 0.0 2.0 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFE42627.1 - 0.022 14.6 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Ribosomal_L1 PF00687.16 EFE42628.1 - 9.9e-47 159.0 3.2 7.5e-24 84.3 0.1 2.0 2 0 0 2 2 2 2 Ribosomal protein L1p/L10e family WH2 PF02205.15 EFE42630.1 - 1.3e-10 40.5 0.5 1.3e-10 40.5 0.3 1.9 2 0 0 2 2 2 1 WH2 motif Musclin PF11037.3 EFE42631.1 - 0.012 15.2 0.1 0.026 14.1 0.1 1.6 1 0 0 1 1 1 0 Insulin-resistance promoting peptide in skeletal muscle TAF1D PF15333.1 EFE42631.1 - 2.7 7.7 8.7 1.6 8.4 4.2 2.0 2 0 0 2 2 2 0 TATA box-binding protein-associated factor 1D SURF4 PF02077.10 EFE42632.1 - 3.9e-72 242.8 12.5 4.7e-72 242.5 8.7 1.0 1 0 0 1 1 1 1 SURF4 family UPF0139 PF03669.8 EFE42632.1 - 0.095 12.2 1.6 0.25 10.8 0.9 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0139) HR_lesion PF05514.6 EFE42632.1 - 7.6 6.3 10.8 0.49 10.2 0.7 2.9 2 1 1 3 3 3 0 HR-like lesion-inducing O-antigen_lig PF13425.1 EFE42632.1 - 8.8 6.3 14.3 1.9 8.4 4.3 2.3 2 0 0 2 2 2 0 O-antigen ligase like membrane protein MRP PF09387.5 EFE42634.1 - 0.036 13.7 1.1 0.66 9.6 0.2 2.3 2 0 0 2 2 2 0 Mitochondrial RNA binding protein MRP Amidase PF01425.16 EFE42635.1 - 5.3e-92 308.9 0.0 6.2e-92 308.7 0.0 1.0 1 0 0 1 1 1 1 Amidase Glycos_transf_1 PF00534.15 EFE42636.1 - 6.8e-13 48.3 0.0 1.2e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFE42636.1 - 0.001 19.1 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EFE42636.1 - 0.0076 16.5 0.0 0.027 14.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 HLH PF00010.21 EFE42638.1 - 5.3e-15 54.8 0.7 1.4e-14 53.5 0.5 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IU_nuc_hydro PF01156.14 EFE42639.1 - 4.5e-55 187.0 1.1 1.9e-40 138.9 0.0 2.1 2 0 0 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase Transketolase_C PF02780.15 EFE42639.1 - 6e-05 22.9 0.2 0.027 14.4 0.0 2.5 2 0 0 2 2 2 2 Transketolase, C-terminal domain Fungal_trans PF04082.13 EFE42641.1 - 5.1e-22 78.0 3.4 8.3e-22 77.3 2.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE42641.1 - 6.2e-08 32.4 9.2 1.3e-07 31.3 6.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NIP_1 PF08995.5 EFE42641.1 - 0.2 11.8 4.5 46 4.2 0.0 2.8 2 1 0 2 2 2 0 Necrosis inducing protein-1 p450 PF00067.17 EFE42642.1 - 1.1e-14 53.8 0.1 1.1e-14 53.8 0.0 1.2 1 1 0 1 1 1 1 Cytochrome P450 EcsB PF05975.7 EFE42642.1 - 0.021 13.2 0.6 0.04 12.4 0.4 1.4 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB Arylsulfotran_2 PF14269.1 EFE42643.1 - 4.5e-109 364.2 2.4 6.6e-109 363.6 1.7 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) p450 PF00067.17 EFE42644.1 - 3.1e-63 213.9 0.0 3.9e-63 213.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S8 PF00082.17 EFE42645.1 - 7.1e-38 130.3 11.2 1e-37 129.8 7.7 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE42645.1 - 1.8e-14 54.0 0.0 3.4e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_M14 PF00246.19 EFE42646.1 - 2.3e-76 257.0 0.0 3e-76 256.6 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.11 EFE42646.1 - 1.5e-11 43.7 0.0 3.4e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Cellulase PF00150.13 EFE42646.1 - 0.048 12.8 0.0 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) AstE_AspA PF04952.9 EFE42646.1 - 0.063 12.1 0.0 0.099 11.4 0.0 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Fungal_trans PF04082.13 EFE42647.1 - 3.2e-18 65.5 0.1 5.7e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Rox3 PF08633.5 EFE42648.1 - 6.7e-51 173.3 0.1 1.3e-50 172.3 0.1 1.5 1 0 0 1 1 1 1 Rox3 mediator complex subunit Chorion_2 PF03964.10 EFE42648.1 - 0.051 14.1 0.3 0.051 14.1 0.2 2.6 2 0 0 2 2 2 0 Chorion family 2 HAD_2 PF13419.1 EFE42649.1 - 8.8e-35 120.4 0.0 1.2e-34 120.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFE42649.1 - 0.0074 16.7 0.0 0.011 16.0 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE42649.1 - 0.012 15.3 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Thr_synth_N PF14821.1 EFE42650.1 - 1.8e-28 98.3 0.0 5.4e-28 96.8 0.0 1.9 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.20 EFE42650.1 - 3.6e-17 62.5 0.0 7.9e-17 61.4 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4202 PF13875.1 EFE42651.1 - 2e-80 268.7 2.6 2.3e-80 268.6 1.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) VIT1 PF01988.14 EFE42652.1 - 5.3e-57 192.7 5.4 6.1e-57 192.5 3.7 1.0 1 0 0 1 1 1 1 VIT family VPS9 PF02204.13 EFE42654.1 - 4.2e-21 74.9 0.0 8.8e-21 73.8 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 EFE42654.1 - 9.1e-05 21.8 0.2 0.0033 16.8 0.0 2.5 2 0 0 2 2 2 1 CUE domain Asn_synthase PF00733.16 EFE42655.1 - 1.4e-55 188.5 0.0 1.8e-55 188.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 EFE42655.1 - 6.8e-08 32.2 0.0 2e-07 30.7 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EFE42655.1 - 0.00037 20.4 0.0 0.0008 19.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 EFE42655.1 - 0.0053 15.9 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.12 EFE42655.1 - 0.16 10.8 0.0 0.32 9.8 0.0 1.4 1 0 0 1 1 1 0 NAD synthase bZIP_1 PF00170.16 EFE42656.1 - 4.3e-13 49.0 4.0 7.9e-13 48.1 2.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFE42656.1 - 2.1e-07 30.6 8.0 4.6e-07 29.5 5.5 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Sugarporin_N PF11471.3 EFE42656.1 - 0.0056 16.2 3.2 0.014 15.0 2.2 1.6 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension bZIP_Maf PF03131.12 EFE42656.1 - 0.027 14.7 7.1 0.069 13.4 4.9 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor AlaDh_PNT_N PF05222.10 EFE42657.1 - 5.1e-41 139.8 0.0 6.4e-41 139.5 0.0 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB PF02233.11 EFE42658.1 - 3.8e-160 533.6 27.6 3.8e-160 533.6 19.1 2.5 2 1 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.16 EFE42658.1 - 1.8e-48 164.3 0.3 4e-48 163.1 0.2 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.10 EFE42658.1 - 2.6e-38 131.1 0.0 8.2e-38 129.4 0.0 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain DUF3814 PF12769.2 EFE42658.1 - 4.2e-31 106.9 3.4 4.2e-31 106.9 2.4 4.5 4 2 2 6 6 6 1 Domain of unknown function (DUF3814) 2-Hacid_dh_C PF02826.14 EFE42658.1 - 0.0032 16.6 1.1 1.6 7.8 0.1 3.5 2 1 1 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_31 PF13847.1 EFE42658.1 - 0.033 13.7 0.0 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Pyr_redox_2 PF07992.9 EFE42658.1 - 0.056 13.3 1.1 0.13 12.1 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_18 PF12847.2 EFE42658.1 - 0.069 13.7 0.0 0.25 11.9 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_8 PF13450.1 EFE42658.1 - 0.069 13.1 1.6 0.75 9.8 1.1 3.0 1 1 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 EFE42658.1 - 0.08 11.7 0.8 0.14 10.9 0.6 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A DUF3938 PF13074.1 EFE42658.1 - 4.1 7.3 5.6 15 5.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3938) PH_6 PF15406.1 EFE42659.1 - 1.3e-37 128.2 2.9 1.3e-37 128.2 2.0 3.4 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.24 EFE42659.1 - 9.7e-06 25.7 0.0 3.1e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 PH domain VIT1 PF01988.14 EFE42659.1 - 0.92 8.9 3.6 2.8 7.3 2.5 1.7 1 0 0 1 1 1 0 VIT family Sulfate_transp PF00916.15 EFE42660.1 - 3.7e-42 144.2 7.7 3.7e-42 144.2 5.3 1.8 2 0 0 2 2 2 1 Sulfate transporter family cNMP_binding PF00027.24 EFE42660.1 - 7.3e-14 51.3 0.0 1.7e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.16 EFE42660.1 - 2.2e-11 43.1 0.1 4.1e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 STAS domain Sld5 PF05916.6 EFE42661.1 - 3.3e-13 49.8 0.3 6.3e-13 48.9 0.1 1.5 1 1 0 1 1 1 1 GINS complex protein INT_SG_DDX_CT_C PF15300.1 EFE42661.1 - 0.086 12.3 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus HMG_box PF00505.14 EFE42662.1 - 4.3e-10 39.7 0.4 1.1e-09 38.4 0.3 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box PHD PF00628.24 EFE42664.1 - 1.6e-08 34.1 10.0 1.6e-08 34.1 6.9 2.1 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.1 EFE42664.1 - 0.0015 17.7 5.3 0.0015 17.7 3.6 2.0 2 0 0 2 2 2 1 PHD-finger Transpep_BrtH PF14399.1 EFE42664.1 - 0.81 8.9 6.1 1.3 8.1 4.2 1.2 1 0 0 1 1 1 0 NlpC/p60-like transpeptidase DUF2252 PF10009.4 EFE42664.1 - 3.6 6.3 15.4 0.86 8.4 7.3 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) Rcd1 PF04078.8 EFE42666.1 - 3.9e-121 402.8 5.7 1.7e-110 367.9 2.2 2.1 1 1 1 2 2 2 2 Cell differentiation family, Rcd1-like PAT1 PF09770.4 EFE42666.1 - 0.12 10.5 27.9 0.16 10.2 19.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 OMP_b-brl PF13505.1 EFE42666.1 - 0.16 11.8 2.5 0.25 11.2 1.7 1.2 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain ThylakoidFormat PF11264.3 EFE42666.1 - 0.47 10.0 6.9 8.5 5.9 5.1 2.3 2 0 0 2 2 2 0 Thylakoid formation protein TFIIA PF03153.8 EFE42666.1 - 3 7.6 21.4 4.2 7.1 14.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.1 EFE42666.1 - 4 6.2 10.3 6.8 5.5 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMEM51 PF15345.1 EFE42667.1 - 0.039 13.6 0.0 0.074 12.7 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 Menin PF05053.8 EFE42670.1 - 0.062 11.4 8.0 0.057 11.5 5.6 1.0 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.8 EFE42670.1 - 0.88 10.0 24.6 1.9 8.9 17.0 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain DUF912 PF06024.7 EFE42670.1 - 5.3 7.1 11.3 8.1 6.5 7.9 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PCI PF01399.22 EFE42671.1 - 3.6e-12 46.5 0.0 5e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 PCI domain RNase_P_Rpp14 PF01900.14 EFE42671.1 - 0.018 14.9 0.2 0.052 13.4 0.0 1.7 2 1 0 2 2 2 0 Rpp14/Pop5 family Rrf2 PF02082.15 EFE42671.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator Dimer_Tnp_hAT PF05699.9 EFE42671.1 - 0.12 12.0 0.9 0.21 11.2 0.2 1.8 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region ADK PF00406.17 EFE42672.1 - 1.8e-37 128.5 0.0 4.9e-37 127.1 0.0 1.7 1 1 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 EFE42672.1 - 1.5e-05 25.3 0.0 2.6e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE42672.1 - 0.00035 21.3 0.0 0.00064 20.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFE42672.1 - 0.034 14.0 0.0 0.39 10.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.12 EFE42672.1 - 0.088 12.1 0.1 0.48 9.7 0.0 2.0 1 1 0 1 1 1 0 Thymidylate kinase MFS_1 PF07690.11 EFE42673.1 - 2.9e-29 101.9 30.7 4e-29 101.4 21.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MARVEL PF01284.18 EFE42674.1 - 0.014 15.2 0.2 0.014 15.2 0.2 1.9 2 0 0 2 2 2 0 Membrane-associating domain DUF3816 PF12822.2 EFE42674.1 - 0.14 12.0 2.0 0.21 11.4 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) GPI2 PF06432.6 EFE42674.1 - 0.16 11.3 2.6 9.2 5.5 0.7 2.2 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase Cnd2 PF05786.9 EFE42675.1 - 6.3e-235 782.0 2.5 7.2e-235 781.8 1.7 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 Sigma70_ner PF04546.8 EFE42675.1 - 5.5 6.5 9.7 0.21 11.1 1.3 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region Ribosomal_60s PF00428.14 EFE42675.1 - 9.4 6.7 9.9 5.2 7.5 0.2 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein Na_Ca_ex PF01699.19 EFE42676.1 - 5.5e-46 155.6 32.3 1.5e-23 82.9 8.7 2.6 2 0 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_4 PF12763.2 EFE42677.1 - 1.2e-15 57.0 0.0 1.2e-12 47.4 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.15 EFE42677.1 - 5e-10 38.6 0.2 1.5e-09 37.1 0.1 1.9 1 0 0 1 1 1 1 WH2 motif DUF1720 PF08226.6 EFE42677.1 - 0.00041 20.3 34.9 0.00041 20.3 24.2 7.1 4 2 3 7 7 7 5 Domain of unknown function (DUF1720) EF-hand_7 PF13499.1 EFE42677.1 - 0.00093 19.2 0.0 0.013 15.6 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 EFE42677.1 - 0.0055 15.9 0.0 0.13 11.6 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 EFE42677.1 - 0.0068 15.9 0.0 0.24 11.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 EFE42677.1 - 0.17 11.8 0.0 12 6.0 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain RNA_pol_L_2 PF13656.1 EFE42678.1 - 9.4e-12 44.1 0.0 3e-09 36.1 0.0 2.2 1 1 1 2 2 2 2 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 EFE42678.1 - 2.6e-07 29.6 0.1 4.1e-06 25.8 0.1 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain NMO PF03060.10 EFE42680.1 - 6.7e-38 130.6 9.8 1.6e-36 126.1 6.8 2.1 1 1 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.13 EFE42680.1 - 1e-07 31.1 4.3 1.9e-07 30.2 3.0 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.20 EFE42680.1 - 2.5e-05 23.3 0.6 0.03 13.2 1.6 2.4 1 1 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 EFE42680.1 - 0.0036 16.2 3.5 0.0051 15.7 2.4 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ETRAMP PF09716.5 EFE42681.1 - 0.021 14.7 0.4 0.021 14.7 0.3 3.9 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) LRR_6 PF13516.1 EFE42682.1 - 3.1e-07 29.7 0.4 3.4 8.0 0.0 7.0 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.2 EFE42682.1 - 1.4e-06 27.7 1.3 0.16 11.6 0.4 5.7 5 2 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE42682.1 - 1.6e-06 27.7 7.2 0.18 11.5 0.1 5.7 4 3 2 6 6 6 2 Leucine rich repeat LRR_1 PF00560.28 EFE42682.1 - 3.1e-05 23.3 2.9 17 5.9 0.0 6.8 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_2 PF07723.8 EFE42682.1 - 2.4 8.8 5.1 2.9 8.5 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 EFE42682.1 - 2.9 8.4 10.8 57 4.5 0.0 6.4 8 1 1 9 9 9 0 Leucine rich repeat GCC2_GCC3 PF07699.8 EFE42684.1 - 0.04 13.4 0.0 0.13 11.9 0.0 1.8 1 0 0 1 1 1 0 GCC2 and GCC3 MFS_1 PF07690.11 EFE42685.1 - 1.1e-33 116.4 51.8 5.3e-24 84.5 12.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE42685.1 - 7e-08 31.4 17.4 7e-08 31.4 12.1 3.3 2 1 0 3 3 3 1 Sugar (and other) transporter DPM3 PF08285.6 EFE42685.1 - 0.31 10.9 2.1 3.4 7.5 0.1 3.4 2 1 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) CorA PF01544.13 EFE42685.1 - 0.5 9.3 1.7 0.96 8.4 1.2 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein p450 PF00067.17 EFE42686.1 - 4.5e-07 28.7 0.0 5.4e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HNH_2 PF13391.1 EFE42687.1 - 2.3e-09 36.8 0.1 7e-09 35.3 0.1 1.9 1 0 0 1 1 1 1 HNH endonuclease APH PF01636.18 EFE42688.1 - 2.3e-08 34.0 0.0 5.6e-08 32.8 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFE42688.1 - 0.00044 19.4 0.0 0.00068 18.8 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.15 EFE42688.1 - 0.0011 18.5 0.0 0.0045 16.5 0.0 1.9 2 0 0 2 2 2 1 Choline/ethanolamine kinase DUF1679 PF07914.6 EFE42688.1 - 0.0098 14.5 0.0 0.017 13.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Pkinase PF00069.20 EFE42689.1 - 1e-16 60.9 0.0 2.5e-16 59.6 0.0 1.6 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42689.1 - 2.5e-10 39.8 0.0 9.2e-10 38.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 EFE42689.1 - 0.092 11.7 0.0 0.23 10.4 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_12 PF13424.1 EFE42689.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Pyr_redox_2 PF07992.9 EFE42690.1 - 7.8e-14 52.0 0.0 2.6e-13 50.2 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE42690.1 - 2.2e-12 47.1 0.0 3.7e-09 36.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE42690.1 - 1.3e-07 31.9 0.1 0.00017 21.6 0.0 3.1 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE42690.1 - 1.3e-07 30.8 0.1 4e-06 25.9 0.1 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 EFE42690.1 - 0.0059 15.5 0.1 2.2 7.0 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFE42690.1 - 0.01 14.7 0.0 1.1 8.1 0.0 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.9 EFE42690.1 - 0.027 13.1 0.0 1.4 7.4 0.0 2.8 2 1 0 3 3 3 0 Tryptophan halogenase TrkA_N PF02254.13 EFE42690.1 - 0.034 14.1 0.0 2.8 7.9 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain Eno-Rase_NADH_b PF12242.3 EFE42690.1 - 0.073 12.8 0.2 0.68 9.7 0.0 2.5 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Fungal_trans PF04082.13 EFE42691.1 - 7.6e-17 61.0 1.2 1.2e-16 60.3 0.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.11 EFE42692.1 - 2.7e-29 101.9 63.4 2.2e-19 69.3 22.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE42692.1 - 7.4e-06 24.6 18.8 7.4e-06 24.6 13.0 1.8 1 1 1 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.2 EFE42692.1 - 0.0021 17.7 7.5 0.013 15.2 3.3 2.7 2 0 0 2 2 2 1 MFS_1 like family His_Phos_1 PF00300.17 EFE42694.1 - 2.1e-07 31.1 0.6 1.8e-05 24.8 0.1 2.5 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Peptidase_M35 PF02102.10 EFE42695.1 - 8.1e-106 353.6 9.7 1e-105 353.3 6.7 1.1 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.1 EFE42695.1 - 1.5e-07 32.0 0.5 3.5e-07 30.8 0.2 1.7 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.1 EFE42695.1 - 8.5e-06 25.3 4.9 6.3e-05 22.5 3.4 2.0 1 1 0 1 1 1 1 Putative peptidase family UPF0160 PF03690.8 EFE42696.1 - 4.5e-111 371.2 0.0 5.2e-111 371.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) 5_nucleotid_C PF02872.13 EFE42697.1 - 2.2e-34 118.7 0.0 3.5e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 EFE42697.1 - 3.4e-09 36.3 0.0 8.3e-09 35.1 0.0 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE42697.1 - 0.016 15.0 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Kinesin PF00225.18 EFE42698.1 - 3e-112 374.6 0.4 3e-112 374.6 0.3 2.0 2 0 0 2 2 2 1 Kinesin motor domain Thiolase_N PF00108.18 EFE42699.1 - 3.5e-96 321.2 1.3 4.5e-96 320.8 0.9 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFE42699.1 - 2.4e-37 127.1 0.7 2.4e-37 127.1 0.5 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EFE42699.1 - 0.00024 20.6 1.1 0.00041 19.9 0.2 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 EFE42699.1 - 0.018 14.6 2.1 3.1 7.5 0.0 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Asp_protease_2 PF13650.1 EFE42700.1 - 0.0071 16.8 0.3 0.013 16.0 0.1 1.4 1 1 0 1 1 1 1 Aspartyl protease DUF4254 PF14063.1 EFE42701.1 - 0.081 12.5 0.1 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4254) UQ_con PF00179.21 EFE42702.1 - 2.4e-44 150.1 0.0 7.5e-44 148.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFE42702.1 - 2.2e-06 27.4 0.0 2.5e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFE42702.1 - 0.072 12.9 0.1 0.097 12.5 0.0 1.5 1 1 0 1 1 1 0 RWD domain Cation_efflux PF01545.16 EFE42703.1 - 5.4e-50 170.0 12.2 5.4e-50 170.0 8.4 3.2 3 0 0 3 3 3 2 Cation efflux family Glyco_trans_1_4 PF13692.1 EFE42704.1 - 3.5e-23 82.2 0.1 1.5e-22 80.1 0.0 1.9 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EFE42704.1 - 2.6e-08 34.1 0.4 4.2e-08 33.4 0.3 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain TFIIIC_delta PF12657.2 EFE42705.1 - 2.6e-44 150.9 0.2 5.5e-44 149.9 0.1 1.6 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.2 EFE42705.1 - 5.7e-26 90.3 1.6 1.1e-25 89.4 1.1 1.5 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex Mito_carr PF00153.22 EFE42706.1 - 3.4e-55 183.7 6.7 4.3e-20 71.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LtrA PF06772.6 EFE42707.1 - 3e-20 72.4 24.5 3e-20 72.4 17.0 2.1 2 0 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) DUF2976 PF11190.3 EFE42707.1 - 0.023 14.1 0.4 0.023 14.1 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) AA_permease PF00324.16 EFE42709.1 - 5.5e-28 97.5 5.9 3.7e-27 94.7 4.1 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE42709.1 - 2.3e-10 39.5 2.4 2.9e-10 39.2 1.7 1.0 1 0 0 1 1 1 1 Amino acid permease 7tm_1 PF00001.16 EFE42709.1 - 0.018 14.1 0.3 0.16 11.0 0.0 2.1 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) FtsX PF02687.16 EFE42710.1 - 0.3 10.8 0.1 0.3 10.8 0.0 3.4 4 0 0 4 4 4 0 FtsX-like permease family CFEM PF05730.6 EFE42711.1 - 2e-12 46.7 3.8 2.9e-12 46.2 2.6 1.2 1 0 0 1 1 1 1 CFEM domain FNIP_N PF14636.1 EFE42713.1 - 7.6e-30 104.0 0.2 7.6e-30 104.0 0.1 4.8 6 1 0 6 6 6 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.1 EFE42713.1 - 0.015 14.8 0.4 0.08 12.5 0.1 2.0 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain DUF3608 PF12257.3 EFE42714.1 - 1.9e-72 243.5 0.0 2e-71 240.1 0.0 2.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 EFE42714.1 - 2.4e-30 104.0 1.3 4.7e-30 103.1 0.9 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CsoS2_M PF12288.3 EFE42715.1 - 0.063 12.4 0.5 0.079 12.1 0.4 1.1 1 0 0 1 1 1 0 Carboxysome shell peptide mid-region Rad60-SLD_2 PF13881.1 EFE42716.1 - 2.1e-12 46.9 0.0 4.3e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 EFE42716.1 - 0.0013 18.8 0.0 0.003 17.7 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.18 EFE42716.1 - 0.0017 17.7 0.0 0.0032 16.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UMP1 PF05348.6 EFE42717.1 - 2e-23 82.7 0.1 2.4e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 DUF3591 PF12157.3 EFE42717.1 - 0.084 11.2 0.1 0.1 10.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3591) Ribosom_S12_S23 PF00164.20 EFE42718.1 - 5.2e-18 64.6 1.3 5.2e-18 64.6 0.9 1.6 2 0 0 2 2 2 1 Ribosomal protein S12/S23 Glyco_transf_15 PF01793.11 EFE42719.1 - 1.3e-138 461.5 4.4 1.7e-138 461.0 3.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Fungal_trans PF04082.13 EFE42720.1 - 6.2e-20 71.1 2.2 1.1e-19 70.3 1.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.1 EFE42720.1 - 3.5e-07 30.1 13.6 0.0001 22.4 4.0 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.21 EFE42720.1 - 0.00072 19.7 16.7 0.18 12.1 5.5 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type Mucin PF01456.12 EFE42720.1 - 0.021 14.6 13.9 0.05 13.3 9.6 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein zf-CHY PF05495.7 EFE42720.1 - 0.54 10.4 6.3 0.12 12.5 1.6 1.9 2 0 0 2 2 2 0 CHY zinc finger zf-C2H2_4 PF13894.1 EFE42720.1 - 3.7 8.0 27.9 0.039 14.2 4.9 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger Tho2 PF11262.3 EFE42721.1 - 0.23 10.4 5.1 0.26 10.2 3.5 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF4407 PF14362.1 EFE42721.1 - 1.3 7.9 9.1 1.5 7.7 6.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAGA-Tad1 PF12767.2 EFE42721.1 - 1.5 8.4 6.9 1.6 8.2 4.8 1.0 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF2011 PF09428.5 EFE42721.1 - 2.9 7.7 20.0 3.6 7.4 13.8 1.1 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) RNase_H2-Ydr279 PF09468.5 EFE42721.1 - 5.1 6.1 13.9 5.9 5.9 9.6 1.0 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Seryl_tRNA_N PF02403.17 EFE42721.1 - 5.1 7.1 12.7 7 6.7 8.8 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Vfa1 PF08432.5 EFE42721.1 - 6.1 6.8 17.6 11 6.0 12.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 UPRTase PF14681.1 EFE42722.1 - 2.3e-63 213.1 0.0 6.7e-63 211.6 0.0 1.6 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EFE42722.1 - 1.1e-05 25.1 0.0 4.8e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain CRCB PF02537.10 EFE42723.1 - 8.5e-35 119.1 19.3 4.7e-22 78.0 3.1 3.9 5 0 0 5 5 5 3 CrcB-like protein JAB PF01398.16 EFE42724.1 - 4.4e-27 94.0 0.0 6.9e-27 93.4 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 EFE42724.1 - 3.1e-06 26.7 0.0 8.1e-06 25.3 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain Pkinase PF00069.20 EFE42725.1 - 2e-21 76.2 0.0 2.7e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42725.1 - 2.2e-18 66.2 0.0 3.9e-18 65.4 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE42725.1 - 0.00032 19.8 0.1 0.00051 19.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE42725.1 - 0.019 14.5 0.0 0.056 13.0 0.0 1.5 1 1 1 2 2 2 0 Choline/ethanolamine kinase MAP65_ASE1 PF03999.7 EFE42726.1 - 1.3e-75 255.2 0.5 1.3e-75 255.2 0.3 2.0 2 0 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) Mnd1 PF03962.10 EFE42726.1 - 0.75 9.4 11.3 0.37 10.4 0.1 3.1 3 0 0 3 3 3 0 Mnd1 family tRNA-synt_1c PF00749.16 EFE42728.1 - 3e-44 150.9 0.0 1.4e-43 148.7 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain CTDII PF01556.13 EFE42729.1 - 6.8e-24 83.5 0.1 6.3e-19 67.6 0.0 2.9 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EFE42729.1 - 4e-13 49.2 18.4 7.1e-13 48.3 12.8 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.26 EFE42729.1 - 4.4e-13 48.7 1.9 9.4e-13 47.7 1.3 1.5 1 0 0 1 1 1 1 DnaJ domain HypA PF01155.14 EFE42729.1 - 0.04 13.6 5.9 0.95 9.1 0.4 2.4 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family YcfA PF07927.7 EFE42729.1 - 0.062 13.2 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 YcfA-like protein Cytochrom_c3_2 PF14537.1 EFE42729.1 - 0.55 10.6 5.4 1.3 9.4 3.7 1.7 1 1 0 1 1 1 0 Cytochrome c3 Stc1 PF12898.2 EFE42729.1 - 1.1 9.3 10.7 2.7 8.1 1.4 2.4 1 1 1 2 2 2 0 Stc1 domain zf-CHY PF05495.7 EFE42729.1 - 2.7 8.2 5.6 2.9 8.0 0.2 2.4 2 0 0 2 2 2 0 CHY zinc finger 4HBT PF03061.17 EFE42730.1 - 3.1e-10 40.0 0.0 4.3e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.1 EFE42730.1 - 0.061 13.7 0.0 0.074 13.5 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily PseudoU_synth_2 PF00849.17 EFE42731.1 - 6.1e-25 87.9 0.0 1.1e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase Glyco_tran_WecB PF03808.8 EFE42731.1 - 0.098 12.0 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family S4 PF01479.20 EFE42731.1 - 0.11 11.9 0.1 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 S4 domain Ribosomal_L32e PF01655.13 EFE42732.1 - 1.7e-37 127.8 0.7 1.1e-29 102.6 0.0 2.0 2 0 0 2 2 2 2 Ribosomal protein L32 Sec2p PF06428.6 EFE42733.1 - 5.4e-10 39.0 12.4 5.4e-10 39.0 8.6 1.9 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p ATG16 PF08614.6 EFE42733.1 - 0.0031 17.3 8.5 0.0031 17.3 5.9 2.3 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) HSBP1 PF06825.7 EFE42733.1 - 0.018 14.6 1.4 0.16 11.5 0.3 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF2072 PF09845.4 EFE42733.1 - 1.1 9.2 4.9 1.5 8.7 0.0 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) Miff PF05644.6 EFE42733.1 - 3.7 7.1 14.0 5.5 6.5 9.5 1.5 1 1 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff RRM_1 PF00076.17 EFE42734.1 - 1.4e-14 53.4 0.0 2.8e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE42734.1 - 2e-13 50.0 0.0 3.4e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE42734.1 - 4.3e-06 26.4 0.0 7.2e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2413 PF10310.4 EFE42734.1 - 1.7 7.3 15.1 2.5 6.8 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) DUF3513 PF12026.3 EFE42734.1 - 2.1 7.8 9.0 3.5 7.1 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) 2-Hacid_dh_C PF02826.14 EFE42735.1 - 6.5e-55 185.0 0.0 8.6e-55 184.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFE42735.1 - 9.7e-17 60.6 0.0 1.1e-16 60.5 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFE42735.1 - 3.3e-07 30.2 0.0 5.4e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GFO_IDH_MocA PF01408.17 EFE42735.1 - 0.003 18.0 0.0 0.014 15.9 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.12 EFE42735.1 - 0.064 13.6 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DcpS_C PF11969.3 EFE42736.1 - 3.9e-05 23.8 0.0 7.1e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 EFE42736.1 - 5.3e-05 23.6 0.0 9.8e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 HIT domain Cyclin_N PF00134.18 EFE42737.1 - 2.6e-43 146.6 0.4 5.7e-43 145.5 0.3 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFE42737.1 - 1.1e-31 109.2 0.2 4.8e-31 107.1 0.0 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain Zn_clus PF00172.13 EFE42739.1 - 0.00065 19.5 12.6 0.0014 18.5 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.5 EFE42739.1 - 0.016 14.4 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 0 Histone chaperone domain CHZ DUF4349 PF14257.1 EFE42739.1 - 0.55 9.4 0.0 0.55 9.4 0.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) RNA_pol_Rpc4 PF05132.9 EFE42740.1 - 2.7e-30 105.0 2.0 4.7e-30 104.2 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase III RPC4 Fmp27 PF10344.4 EFE42742.1 - 4.2e-174 580.6 0.0 3.3e-173 577.6 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial protein from FMP27 Apt1 PF10351.4 EFE42742.1 - 1.1e-154 515.7 0.0 2.2e-154 514.7 0.0 1.6 1 0 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.4 EFE42742.1 - 1.9e-145 484.9 1.2 3e-145 484.2 0.8 1.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.4 EFE42742.1 - 4.4e-52 176.1 0.0 1.2e-51 174.7 0.0 1.8 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 EFE42742.1 - 2.5e-51 173.5 0.1 6.7e-51 172.1 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 EFE42742.1 - 8.3e-27 93.6 0.0 2.8e-26 91.9 0.0 2.0 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain PH_7 PF15408.1 EFE42742.1 - 0.071 12.9 0.0 0.28 11.0 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain B-block_TFIIIC PF04182.7 EFE42744.1 - 5.7e-21 74.1 0.1 1.3e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC MarR_2 PF12802.2 EFE42744.1 - 0.0039 16.8 2.4 0.013 15.1 0.1 3.1 3 0 0 3 3 3 1 MarR family RNA_pol_Rpc34 PF05158.7 EFE42744.1 - 0.35 9.9 0.0 5.2 6.1 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase Rpc34 subunit UQ_con PF00179.21 EFE42745.1 - 4.9e-20 71.3 0.0 7.3e-20 70.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rubredoxin PF00301.15 EFE42745.1 - 0.036 13.9 0.3 0.089 12.6 0.2 1.7 1 0 0 1 1 1 0 Rubredoxin DUF605 PF04652.11 EFE42745.1 - 0.44 9.8 4.1 0.67 9.3 2.9 1.3 1 0 0 1 1 1 0 Vta1 like zf-DHHC PF01529.15 EFE42746.1 - 7.8e-41 139.3 7.7 1.8e-40 138.1 5.3 1.6 1 0 0 1 1 1 1 DHHC palmitoyltransferase TFIIE-A_C-term PF11521.3 EFE42748.1 - 0.36 10.7 4.6 0.38 10.7 3.2 1.1 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Mak16 PF04874.9 EFE42748.1 - 0.96 9.5 8.3 0.87 9.7 5.7 1.0 1 0 0 1 1 1 0 Mak16 protein C-terminal region Nucleoplasmin PF03066.10 EFE42748.1 - 2.1 7.8 10.2 1.9 7.9 7.1 1.0 1 0 0 1 1 1 0 Nucleoplasmin DUF688 PF05097.7 EFE42748.1 - 2.3 7.0 5.0 2.1 7.1 3.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF688) AF1Q PF15017.1 EFE42748.1 - 4.3 7.3 6.8 4.3 7.3 4.7 1.1 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator CENP-B_dimeris PF09026.5 EFE42748.1 - 4.7 7.4 10.0 4.2 7.6 6.9 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain S-antigen PF05756.6 EFE42748.1 - 4.9 7.1 6.4 4.9 7.2 4.4 1.0 1 0 0 1 1 1 0 S-antigen protein BSP_II PF05432.6 EFE42748.1 - 6.3 5.9 10.6 6.2 5.9 7.3 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Ribosomal_60s PF00428.14 EFE42748.1 - 6.4 7.2 11.8 7.6 7.0 8.2 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein PBP1_TM PF14812.1 EFE42748.1 - 6.9 7.0 9.0 6.6 7.1 6.3 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.6 EFE42748.1 - 8.9 6.1 6.9 8.1 6.2 4.8 1.0 1 0 0 1 1 1 0 RXT2-like, N-terminal Rhomboid PF01694.17 EFE42749.1 - 3e-35 121.3 8.8 3e-35 121.3 6.1 2.5 3 0 0 3 3 3 1 Rhomboid family GST_C_2 PF13410.1 EFE42750.1 - 0.00013 21.8 0.0 0.00027 20.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE42750.1 - 0.00029 21.2 0.0 0.00043 20.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFE42750.1 - 0.01 16.0 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE42750.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Kinetochor_Ybp2 PF08568.5 EFE42751.1 - 7.9e-118 394.4 0.2 9.4e-118 394.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin PLDc PF00614.17 EFE42752.1 - 5.5e-13 48.2 0.6 4.8e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 EFE42752.1 - 1.4e-12 47.4 0.0 3.2e-06 26.8 0.0 3.6 3 1 0 3 3 3 2 PLD-like domain Cyanate_lyase PF02560.9 EFE42753.1 - 6.7e-29 99.2 0.0 1.1e-28 98.5 0.0 1.4 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_26 PF13443.1 EFE42753.1 - 2.1e-05 24.6 0.0 3.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_31 PF13560.1 EFE42753.1 - 0.00018 21.6 0.0 0.00028 21.0 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.17 EFE42753.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix HTH_19 PF12844.2 EFE42753.1 - 0.078 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain zf-C2H2_4 PF13894.1 EFE42754.1 - 1.4e-06 28.2 13.6 0.23 11.8 0.1 5.7 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE42754.1 - 0.00015 21.8 19.9 0.082 13.2 0.0 5.5 6 0 0 6 6 6 2 Zinc finger, C2H2 type zf-met PF12874.2 EFE42754.1 - 0.065 13.4 0.0 0.065 13.4 0.0 4.4 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EFE42754.1 - 0.089 12.9 0.1 0.089 12.9 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EFE42754.1 - 0.2 11.8 14.7 3 7.9 0.0 4.2 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_5 PF13719.1 EFE42754.1 - 1.4 8.5 5.5 22 4.7 0.8 3.0 2 1 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EFE42754.1 - 1.6 8.4 5.6 22 4.8 0.1 3.0 2 1 0 2 2 2 0 zinc-ribbon domain zf-CSL PF05207.8 EFE42754.1 - 2.3 7.7 6.5 11 5.6 0.0 2.7 2 1 0 2 2 2 0 CSL zinc finger Cytochrom_CIII PF02085.11 EFE42754.1 - 3.5 7.7 8.9 9.9 6.3 6.2 1.8 1 0 0 1 1 1 0 Class III cytochrome C family C1_4 PF07975.7 EFE42754.1 - 9.4 6.3 9.3 40 4.3 3.3 2.8 2 1 0 2 2 2 0 TFIIH C1-like domain FXR1P_C PF12235.3 EFE42756.1 - 1.3 9.0 12.7 2 8.4 8.7 1.4 1 1 0 1 1 1 0 Fragile X-related 1 protein C terminal MFS_1 PF07690.11 EFE42757.1 - 1.2e-05 24.2 4.6 0.00074 18.3 0.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF389 PF04087.9 EFE42757.1 - 0.033 14.1 1.8 2 8.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF389) MFS_1 PF07690.11 EFE42758.1 - 1e-26 93.5 36.8 1.8e-26 92.7 25.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.14 EFE42758.1 - 8.2e-05 21.3 0.9 8.2e-05 21.3 0.6 1.7 2 0 0 2 2 2 1 LacY proton/sugar symporter FAD_binding_3 PF01494.14 EFE42759.1 - 7.5e-15 54.8 0.0 1.2e-10 40.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 EFE42759.1 - 8.5e-06 24.9 0.0 3.4e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE42759.1 - 0.00013 21.9 0.0 0.00031 20.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 EFE42759.1 - 0.00015 20.9 1.5 0.0018 17.4 1.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 EFE42759.1 - 0.00089 18.2 0.0 0.0021 17.0 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.22 EFE42759.1 - 0.00097 19.5 0.0 0.0018 18.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE42759.1 - 0.0013 17.2 0.0 0.0026 16.2 0.0 1.5 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 EFE42759.1 - 0.0016 18.3 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EFE42759.1 - 0.024 14.2 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.5 EFE42759.1 - 0.089 11.5 0.0 0.32 9.7 0.0 1.8 1 1 0 1 1 1 0 Squalene epoxidase DUF1517 PF07466.6 EFE42759.1 - 0.11 11.4 0.3 0.18 10.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) DNA_pol_B PF00136.16 EFE42760.1 - 7.5e-145 483.2 4.4 1e-144 482.8 3.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EFE42760.1 - 1.1e-81 274.2 0.2 2.5e-81 273.0 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 EFE42760.1 - 1.2e-24 86.1 2.6 3e-24 84.8 1.8 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.1 EFE42760.1 - 3.6e-05 23.6 0.2 0.00014 21.7 0.1 2.1 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.4 EFE42760.1 - 0.00083 18.9 0.1 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB AKNA PF12443.3 EFE42760.1 - 0.0035 17.3 2.4 0.0068 16.4 1.0 2.0 2 0 0 2 2 2 1 AT-hook-containing transcription factor C1_1 PF00130.17 EFE42760.1 - 0.0059 16.3 6.9 0.025 14.2 0.8 2.7 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Fungal_trans_2 PF11951.3 EFE42761.1 - 1.2e-09 37.3 1.2 8e-09 34.5 0.3 2.0 2 0 0 2 2 2 2 Fungal specific transcription factor domain Pkinase PF00069.20 EFE42762.1 - 2.9e-32 111.8 0.0 7.3e-19 67.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42762.1 - 2.7e-13 49.6 0.0 4.2e-06 26.0 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFE42762.1 - 0.066 12.1 0.0 7 5.5 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Glyco_hydro_47 PF01532.15 EFE42763.1 - 4.5e-174 579.3 0.0 5.2e-174 579.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 EF-1_beta_acid PF10587.4 EFE42763.1 - 0.21 11.7 3.0 0.51 10.5 2.1 1.6 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region LIP PF03583.9 EFE42764.1 - 2.2e-80 269.9 0.0 2.8e-80 269.6 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_6 PF12697.2 EFE42764.1 - 7.5e-05 22.7 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Syja_N PF02383.13 EFE42765.1 - 1e-90 303.7 0.0 1.8e-90 302.9 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain DUF2454 PF10521.4 EFE42766.1 - 1.3e-80 270.4 1.2 1.7e-80 270.0 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) PolyA_pol PF01743.15 EFE42767.1 - 3.8e-23 82.0 0.0 8.9e-23 80.8 0.0 1.7 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 EFE42767.1 - 3e-06 26.7 0.0 7.2e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.1 EFE42767.1 - 0.00073 19.3 0.1 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative Tim44 PF04280.10 EFE42767.1 - 0.072 13.0 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 Tim44-like domain TRAPPC-Trs85 PF12739.2 EFE42768.1 - 2.5e-114 382.1 0.1 6.3e-113 377.5 0.0 2.1 2 0 0 2 2 2 2 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DNase_NucA_NucB PF14040.1 EFE42769.1 - 0.013 15.6 0.1 0.023 14.8 0.1 1.3 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB Snf7 PF03357.16 EFE42770.1 - 5.2e-18 65.0 10.3 5.2e-18 65.0 7.2 2.1 1 1 1 2 2 2 1 Snf7 Reo_sigmaC PF04582.7 EFE42770.1 - 0.029 13.5 3.4 0.05 12.7 2.4 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF1729 PF08354.5 EFE42770.1 - 0.039 13.7 0.1 0.12 12.2 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) SPOB_a PF14689.1 EFE42770.1 - 0.084 12.4 0.1 0.37 10.3 0.0 2.1 1 0 0 1 1 1 0 Sensor_kinase_SpoOB-type, alpha-helical domain PspA_IM30 PF04012.7 EFE42770.1 - 0.22 10.8 20.1 4 6.7 13.2 2.5 1 1 1 2 2 2 0 PspA/IM30 family DUF948 PF06103.6 EFE42770.1 - 0.84 9.5 8.4 1.4 8.8 0.4 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) COG5 PF10392.4 EFE42770.1 - 1.2 9.1 8.0 1.3 9.0 0.6 3.0 2 2 1 3 3 3 0 Golgi transport complex subunit 5 FlaC_arch PF05377.6 EFE42770.1 - 1.5 8.7 8.6 18 5.2 0.1 3.9 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.15 EFE42770.1 - 1.8 8.3 15.5 1.2 8.9 0.2 3.1 2 1 0 2 2 2 0 Prefoldin subunit BLOC1_2 PF10046.4 EFE42770.1 - 3.7 7.7 13.0 6.4 6.9 0.2 4.0 2 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C3HC4_2 PF13923.1 EFE42771.1 - 2e-08 34.1 24.9 1.3e-07 31.5 12.5 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE42771.1 - 1.6e-06 27.7 21.8 3.7e-06 26.6 11.3 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 EFE42771.1 - 2e-06 27.3 17.0 2e-06 27.3 11.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 EFE42771.1 - 2.1e-06 27.3 7.3 2.1e-06 27.3 5.1 1.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.1 EFE42771.1 - 3.3e-06 26.6 14.0 3.3e-06 26.6 9.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE42771.1 - 4.4e-06 26.3 16.7 4.4e-06 26.3 11.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain SAP PF02037.22 EFE42771.1 - 4.4e-05 22.8 0.0 9.1e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 SAP domain zf-C3HC4_4 PF15227.1 EFE42771.1 - 0.00027 20.7 20.2 0.00063 19.5 11.9 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFE42771.1 - 0.0024 17.5 8.8 0.0024 17.5 6.1 2.7 2 1 0 2 2 2 1 RING-type zinc-finger U-box PF04564.10 EFE42771.1 - 0.016 15.1 0.3 0.057 13.3 0.0 2.1 3 0 0 3 3 2 0 U-box domain Rad50_zn_hook PF04423.9 EFE42771.1 - 0.078 12.4 7.8 4.9 6.7 2.1 3.2 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-Apc11 PF12861.2 EFE42771.1 - 0.17 11.7 5.2 0.44 10.4 3.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EFE42771.1 - 0.77 9.9 12.3 0.14 12.2 5.5 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger Mob_synth_C PF06463.8 EFE42771.1 - 2.2 7.9 10.4 0.49 10.0 4.7 1.7 2 0 0 2 2 2 0 Molybdenum Cofactor Synthesis C CDC27 PF09507.5 EFE42772.1 - 4.6e-65 220.5 34.0 5.4e-65 220.3 23.6 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 DUF1237 PF06824.6 EFE42773.1 - 8.3e-175 581.4 0.1 6.9e-173 575.1 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1237) RRM_1 PF00076.17 EFE42774.1 - 0.0052 16.3 0.0 0.98 9.0 0.0 2.5 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE42774.1 - 0.017 15.0 0.0 0.046 13.6 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE42774.1 - 0.15 11.9 0.0 0.49 10.2 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NMD3 PF04981.8 EFE42775.1 - 7.7e-74 247.7 3.8 1.1e-73 247.2 2.6 1.2 1 0 0 1 1 1 1 NMD3 family FYVE PF01363.16 EFE42775.1 - 1.2 9.1 9.2 5 7.0 4.0 2.4 2 0 0 2 2 2 0 FYVE zinc finger HypA PF01155.14 EFE42775.1 - 5.3 6.7 11.8 2.8 7.6 0.9 3.3 4 1 1 5 5 5 0 Hydrogenase expression/synthesis hypA family DZR PF12773.2 EFE42775.1 - 8.6 6.2 11.4 1.5e+02 2.3 0.0 2.8 2 1 0 2 2 2 0 Double zinc ribbon Oligomerisation PF02410.10 EFE42776.1 - 0.001 19.0 0.0 0.46 10.5 0.1 2.5 2 0 0 2 2 2 2 Oligomerisation domain Pex2_Pex12 PF04757.9 EFE42777.1 - 2.3e-55 187.5 2.5 3e-55 187.1 1.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.1 EFE42777.1 - 4.6e-07 29.6 2.2 8.1e-07 28.8 1.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EFE42777.1 - 8.6e-07 28.8 3.2 1.3e-06 28.2 1.4 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE42777.1 - 0.0013 18.5 3.0 0.0029 17.4 2.1 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFE42777.1 - 0.003 17.1 1.5 0.0057 16.2 1.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE42777.1 - 0.03 13.9 0.7 0.061 13.0 0.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Mito_carr PF00153.22 EFE42778.1 - 4.7e-49 164.0 1.4 2.6e-17 62.2 0.2 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein DDT PF02791.12 EFE42779.1 - 4.4e-19 67.9 2.1 7.2e-19 67.3 1.5 1.3 1 0 0 1 1 1 1 DDT domain WHIM2 PF15613.1 EFE42779.1 - 1.1e-12 47.3 0.6 2.5e-12 46.1 0.4 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 WHIM3 PF15614.1 EFE42779.1 - 3.6e-05 23.4 0.2 9.6e-05 22.0 0.1 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 3 WHIM1 PF15612.1 EFE42779.1 - 0.00078 19.2 0.2 0.0033 17.2 0.1 2.2 1 1 1 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Alg6_Alg8 PF03155.10 EFE42780.1 - 3.4e-129 431.7 25.7 4.6e-129 431.2 17.8 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Lectin_leg-like PF03388.8 EFE42781.1 - 1.3e-17 63.6 0.0 2.2e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Legume-like lectin family TMF_TATA_bd PF12325.3 EFE42781.1 - 0.0068 16.1 0.7 0.011 15.4 0.5 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding TBPIP PF07106.8 EFE42781.1 - 0.013 15.0 0.9 0.02 14.4 0.7 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ALMT PF11744.3 EFE42781.1 - 0.016 13.8 0.1 0.022 13.4 0.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Spectrin PF00435.16 EFE42781.1 - 0.13 12.5 2.8 1.3 9.3 0.1 2.3 1 1 0 2 2 2 0 Spectrin repeat APG6 PF04111.7 EFE42781.1 - 1.5 7.7 4.0 2.3 7.2 2.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 PHD PF00628.24 EFE42782.1 - 6.7e-18 64.1 16.1 1.4e-11 43.8 4.7 2.5 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.1 EFE42782.1 - 0.004 16.4 5.2 0.8 8.9 1.5 2.6 2 0 0 2 2 2 2 PHD/FYVE-zinc-finger like domain Rhabdo_M2 PF04785.7 EFE42782.1 - 0.049 12.6 0.2 0.71 8.8 0.0 2.1 2 0 0 2 2 2 0 Rhabdovirus matrix protein M2 C1_1 PF00130.17 EFE42782.1 - 2.6 7.8 7.3 12 5.7 0.9 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.1 EFE42782.1 - 4.8 6.5 9.8 2.2 7.6 1.0 3.1 3 0 0 3 3 3 0 PHD-finger DUF1777 PF08648.7 EFE42783.1 - 0.0081 15.9 6.4 0.01 15.5 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) Peptidase_M24 PF00557.19 EFE42784.1 - 7.9e-09 35.3 0.4 1.7e-08 34.2 0.3 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 Exo_endo_phos PF03372.18 EFE42786.1 - 5.3e-11 42.9 0.0 6.8e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EFE42786.1 - 0.0038 16.8 0.0 0.0068 16.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase SNF5 PF04855.7 EFE42787.1 - 5.4e-76 255.2 0.3 1.1e-75 254.2 0.0 1.6 2 0 0 2 2 2 1 SNF5 / SMARCB1 / INI1 HEAT_2 PF13646.1 EFE42788.1 - 3e-09 37.0 7.9 5.3e-07 29.8 0.4 4.5 3 1 0 4 4 4 2 HEAT repeats HEAT PF02985.17 EFE42788.1 - 8e-07 28.6 3.9 0.074 13.1 0.0 6.0 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 EFE42788.1 - 0.0029 18.0 11.6 0.031 14.7 0.6 5.0 5 0 0 5 5 5 2 HEAT-like repeat CLASP_N PF12348.3 EFE42788.1 - 0.015 14.6 0.1 1.2 8.3 0.0 3.1 2 1 1 3 3 3 0 CLASP N terminal Adeno_terminal PF02459.10 EFE42788.1 - 0.064 11.4 3.5 0.17 10.0 2.5 1.7 1 0 0 1 1 1 0 Adenoviral DNA terminal protein MFS_1 PF07690.11 EFE42789.1 - 1.9e-27 95.9 31.4 1.9e-27 95.9 21.8 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily zf-RING_2 PF13639.1 EFE42790.1 - 2.8e-09 36.6 1.6 2.8e-09 36.6 1.1 3.5 3 1 0 3 3 3 1 Ring finger domain PHD PF00628.24 EFE42790.1 - 4.2e-09 35.9 8.1 4.2e-09 35.9 5.6 2.6 2 0 0 2 2 2 1 PHD-finger zf-rbx1 PF12678.2 EFE42790.1 - 1.1e-06 28.6 0.7 1.1e-06 28.6 0.5 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EFE42790.1 - 4.2e-06 26.3 1.7 4.2e-06 26.3 1.2 2.8 2 2 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFE42790.1 - 4.4e-06 26.6 1.4 4.4e-06 26.6 0.9 3.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE42790.1 - 1.5e-05 24.5 3.5 1.5e-05 24.5 2.4 2.8 2 2 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE42790.1 - 6.1e-05 22.6 5.9 6.1e-05 22.6 4.1 3.2 2 2 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.1 EFE42790.1 - 9.2e-05 21.6 3.7 0.00021 20.5 2.5 1.6 1 0 0 1 1 1 1 PHD-finger zf-Apc11 PF12861.2 EFE42790.1 - 0.00041 20.1 0.3 0.00041 20.1 0.2 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 EFE42790.1 - 0.018 14.5 3.1 0.024 14.1 0.3 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-PHD-like PF15446.1 EFE42790.1 - 0.019 14.2 1.3 0.019 14.2 0.9 2.2 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain DUF1644 PF07800.7 EFE42790.1 - 0.091 12.6 4.3 0.29 10.9 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) zf-RING_UBOX PF13445.1 EFE42790.1 - 0.15 11.7 6.0 0.68 9.7 0.0 3.4 3 0 0 3 3 3 0 RING-type zinc-finger zf-RING_4 PF14570.1 EFE42790.1 - 1.1 8.8 7.3 0.078 12.5 0.7 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Saccharop_dh PF03435.13 EFE42791.1 - 4e-16 58.9 0.0 4.6e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_10 PF13460.1 EFE42791.1 - 0.0036 17.3 0.0 0.011 15.7 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding Shikimate_DH PF01488.15 EFE42791.1 - 0.0043 17.1 0.0 0.005 16.9 0.0 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.19 EFE42791.1 - 0.02 15.2 0.0 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 EFE42791.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Abhydrolase_6 PF12697.2 EFE42793.1 - 1.5e-09 38.0 0.0 2e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE42793.1 - 1.7e-05 24.5 0.0 0.00043 19.8 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold SinI PF08671.5 EFE42793.1 - 0.082 12.3 0.1 0.34 10.3 0.0 2.1 2 0 0 2 2 2 0 Anti-repressor SinI Pinin_SDK_memA PF04696.8 EFE42794.1 - 1.3e-25 89.5 8.2 1.3e-25 89.5 5.7 1.9 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region DIOX_N PF14226.1 EFE42795.1 - 2.8e-28 98.7 0.0 4.6e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFE42795.1 - 2e-20 72.9 0.1 5.1e-20 71.6 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF2141 PF09912.4 EFE42795.1 - 0.035 13.7 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) BSP_II PF05432.6 EFE42796.1 - 0.022 14.0 0.6 0.026 13.8 0.4 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CheB_methylest PF01339.12 EFE42796.1 - 0.07 12.5 0.1 0.57 9.5 0.0 2.0 2 0 0 2 2 2 0 CheB methylesterase MFS_1 PF07690.11 EFE42797.1 - 1.3e-37 129.3 48.7 2.3e-37 128.5 32.8 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE42797.1 - 5.8e-12 44.6 10.7 8.9e-12 43.9 7.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) p450 PF00067.17 EFE42798.1 - 9e-39 133.2 0.0 1.2e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.21 EFE42799.1 - 4.7e-70 235.9 0.0 7.6e-70 235.2 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EFE42799.1 - 3.8e-32 110.6 0.0 7.1e-32 109.7 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 EFE42799.1 - 3.8e-28 98.7 0.0 8e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain NAD_binding_4 PF07993.7 EFE42799.1 - 1.1e-24 86.6 0.0 4.6e-24 84.7 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein Methyltransf_12 PF08242.7 EFE42799.1 - 2.5e-13 50.3 0.0 5.9e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE42799.1 - 8.7e-12 44.8 0.0 2.2e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 EFE42799.1 - 1.6e-09 37.8 0.2 4e-09 36.6 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_11 PF08241.7 EFE42799.1 - 1.4e-08 35.0 0.0 4.7e-08 33.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE42799.1 - 2.1e-08 34.0 0.0 1.4e-07 31.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Epimerase PF01370.16 EFE42799.1 - 1.3e-06 28.0 0.0 2.6e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.1 EFE42799.1 - 1.4e-06 28.5 0.0 4.3e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE42799.1 - 7.1e-06 26.5 0.0 2.4e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE42799.1 - 1.6e-05 24.1 0.0 0.00017 20.8 0.0 2.5 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family adh_short PF00106.20 EFE42799.1 - 2.9e-05 24.0 0.1 7.2e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Thiolase_N PF00108.18 EFE42799.1 - 3.4e-05 22.9 1.2 8.3e-05 21.6 0.1 2.0 3 0 0 3 3 3 1 Thiolase, N-terminal domain Methyltransf_32 PF13679.1 EFE42799.1 - 7.2e-05 22.4 0.0 0.00018 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE42799.1 - 0.00097 19.1 0.0 0.0045 16.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Polysacc_synt_2 PF02719.10 EFE42799.1 - 0.0029 16.5 0.0 0.016 14.1 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RrnaAD PF00398.15 EFE42799.1 - 0.0067 15.4 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase KR PF08659.5 EFE42799.1 - 0.01 15.4 0.1 0.024 14.2 0.1 1.6 1 0 0 1 1 1 0 KR domain DXP_reductoisom PF02670.11 EFE42799.1 - 0.018 15.5 0.4 0.05 14.1 0.1 1.9 2 0 0 2 2 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Methyltransf_28 PF02636.12 EFE42799.1 - 0.068 12.5 0.0 0.2 11.0 0.0 1.8 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Abhydrolase_5 PF12695.2 EFE42799.1 - 0.07 12.8 0.0 2.7 7.7 0.0 2.9 3 0 0 3 3 3 0 Alpha/beta hydrolase family NodS PF05401.6 EFE42799.1 - 0.095 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) DREV PF05219.7 EFE42799.1 - 0.17 10.7 0.0 0.81 8.5 0.0 1.9 2 0 0 2 2 2 0 DREV methyltransferase RmlD_sub_bind PF04321.12 EFE42799.1 - 0.21 10.4 0.0 3.8 6.3 0.0 2.5 3 0 0 3 3 3 0 RmlD substrate binding domain Pkinase PF00069.20 EFE42800.1 - 2.2e-08 33.5 0.1 0.00079 18.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Cofilin_ADF PF00241.15 EFE42801.1 - 2.8e-19 69.2 0.0 3.2e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Mito_carr PF00153.22 EFE42802.1 - 1.3e-67 223.5 1.9 5.4e-22 77.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CAF1 PF04857.15 EFE42803.1 - 4.3e-19 68.8 0.0 4.9e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease HDA2-3 PF11496.3 EFE42803.1 - 0.072 11.8 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 CAF1 PF04857.15 EFE42804.1 - 1.6e-17 63.7 0.0 1.7e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease DUF1583 PF07622.6 EFE42804.1 - 0.12 10.8 0.0 0.14 10.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1583) TFIIF_alpha PF05793.7 EFE42805.1 - 0.00096 17.6 14.9 0.0014 17.0 10.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Daxx PF03344.10 EFE42805.1 - 0.0063 15.0 15.0 0.01 14.3 10.4 1.3 1 0 0 1 1 1 1 Daxx Family DUF1777 PF08648.7 EFE42805.1 - 0.032 13.9 14.3 0.057 13.1 9.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) SAPS PF04499.10 EFE42805.1 - 0.037 12.6 6.7 0.06 11.9 4.6 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.2 EFE42805.1 - 0.17 9.5 10.4 0.23 9.1 7.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein OmpH PF03938.9 EFE42805.1 - 0.71 9.7 15.0 1.4 8.8 10.4 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GAGA_bind PF06217.7 EFE42805.1 - 0.78 9.6 10.0 1.3 8.9 7.0 1.5 1 0 0 1 1 1 0 GAGA binding protein-like family TRAP_alpha PF03896.11 EFE42805.1 - 1.6 7.6 9.3 21 3.9 0.0 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Plasmodium_Vir PF05795.6 EFE42805.1 - 1.8 7.6 7.9 2.9 7.0 5.5 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein U79_P34 PF03064.11 EFE42805.1 - 2.2 7.7 16.1 3.5 7.0 11.2 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF1675 PF07897.6 EFE42805.1 - 3.2 7.5 14.8 8.5 6.1 10.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Zip PF02535.17 EFE42805.1 - 4.8 6.0 4.6 8.9 5.2 3.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Ycf1 PF05758.7 EFE42805.1 - 4.9 4.7 12.3 6.4 4.3 8.5 1.1 1 0 0 1 1 1 0 Ycf1 Borrelia_P83 PF05262.6 EFE42805.1 - 5.2 5.2 17.0 7.6 4.6 11.8 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1682 PF07946.9 EFE42805.1 - 5.3 5.8 17.5 10 4.8 12.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MFS_1 PF07690.11 EFE42807.1 - 9e-39 133.1 26.2 9e-39 133.1 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFE42807.1 - 3.3e-05 22.2 2.3 5.4e-05 21.5 1.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2178 PF09946.4 EFE42807.1 - 0.024 14.3 0.3 0.094 12.4 0.2 2.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) DUF4231 PF14015.1 EFE42807.1 - 2.4 8.1 4.3 2.1 8.3 0.1 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF4231) Herpes_US9 PF06072.6 EFE42807.1 - 6.1 6.7 5.7 21 5.0 0.6 3.0 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 BBP1_C PF15272.1 EFE42808.1 - 9.5 5.7 9.1 2.6 7.5 0.6 2.9 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal Myosin_head PF00063.16 EFE42809.1 - 1.9e-246 819.4 0.0 1.9e-246 819.4 0.0 2.2 4 0 0 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.14 EFE42809.1 - 5e-09 34.4 139.2 0.00018 19.4 42.3 3.0 1 1 1 2 2 2 2 Myosin tail Myosin_N PF02736.14 EFE42809.1 - 0.00012 21.7 0.0 0.00028 20.4 0.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.3 EFE42809.1 - 0.00069 19.5 12.1 0.00069 19.5 8.4 9.6 2 1 10 12 12 12 3 Afadin- and alpha -actinin-Binding AAA_13 PF13166.1 EFE42809.1 - 0.0017 16.8 25.5 0.0017 16.8 17.7 5.5 2 1 3 5 5 5 2 AAA domain Reo_sigmaC PF04582.7 EFE42809.1 - 0.019 14.1 38.8 0.17 11.0 4.5 5.2 2 2 2 5 5 5 0 Reovirus sigma C capsid protein AAA_19 PF13245.1 EFE42809.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain DUF4239 PF14023.1 EFE42809.1 - 0.22 10.8 0.0 0.22 10.8 0.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4239) Myosin_tail_1 PF01576.14 EFE42810.1 - 6.4e-25 87.0 115.4 7.8e-25 86.7 52.3 2.7 1 1 1 2 2 2 2 Myosin tail Filament PF00038.16 EFE42810.1 - 4.1e-06 26.4 98.0 0.081 12.3 19.6 4.6 1 1 2 4 4 4 4 Intermediate filament protein DUF2353 PF09789.4 EFE42810.1 - 0.0039 16.5 20.5 0.0039 16.5 14.2 4.3 1 1 2 4 4 4 1 Uncharacterized coiled-coil protein (DUF2353) DUF869 PF05911.6 EFE42810.1 - 0.028 12.6 82.2 0.013 13.8 23.5 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) Reo_sigmaC PF04582.7 EFE42810.1 - 0.061 12.4 39.0 0.12 11.5 1.8 5.2 1 1 3 5 5 5 0 Reovirus sigma C capsid protein IncA PF04156.9 EFE42810.1 - 2.5 7.6 118.2 0.65 9.5 4.8 6.4 1 1 4 5 5 5 0 IncA protein Response_reg PF00072.19 EFE42811.1 - 2.9e-21 75.5 0.0 9.3e-14 51.3 0.0 2.4 2 0 0 2 2 2 2 Response regulator receiver domain DUF2052 PF09747.4 EFE42812.1 - 4.6e-30 104.8 11.4 1.4e-29 103.3 7.9 1.7 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Spermine_synth PF01564.12 EFE42813.1 - 8e-05 21.6 0.2 0.00013 20.9 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_26 PF13659.1 EFE42813.1 - 0.00022 21.2 0.0 0.00045 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE42813.1 - 0.027 14.1 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Y_phosphatase3 PF13350.1 EFE42814.1 - 2.9e-47 160.9 0.0 5.4e-47 160.0 0.0 1.4 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3C PF13348.1 EFE42814.1 - 1.3e-13 50.8 0.3 8.5e-13 48.2 0.0 2.4 2 1 1 3 3 3 1 Tyrosine phosphatase family C-terminal region Y_phosphatase2 PF03162.8 EFE42814.1 - 0.0053 16.1 0.0 0.0081 15.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Lysis_col PF02402.11 EFE42814.1 - 0.0078 15.7 0.5 0.017 14.6 0.3 1.5 1 0 0 1 1 1 1 Lysis protein Y_phosphatase PF00102.22 EFE42814.1 - 0.019 14.3 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EFE42814.1 - 0.044 13.8 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Peptidase_C12 PF01088.16 EFE42815.1 - 2.6e-47 160.7 0.0 3.3e-47 160.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Glyoxalase_2 PF12681.2 EFE42815.1 - 0.11 13.1 0.0 0.18 12.4 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain Peptidase_S9 PF00326.16 EFE42816.1 - 3.5e-49 166.9 0.5 7.7e-49 165.7 0.1 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family PD40 PF07676.7 EFE42816.1 - 5.2e-08 32.3 0.7 0.011 15.3 0.0 4.8 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Abhydrolase_5 PF12695.2 EFE42816.1 - 2.6e-07 30.4 0.0 4.8e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLIC PF05783.6 EFE42817.1 - 5.2e-26 91.3 9.0 1.1e-14 54.0 0.0 4.3 3 1 0 4 4 4 4 Dynein light intermediate chain (DLIC) Myb_CC_LHEQLE PF14379.1 EFE42817.1 - 0.021 14.3 2.7 0.051 13.1 1.9 1.6 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif RRM_1 PF00076.17 EFE42818.1 - 4.3e-20 71.1 0.1 2.2e-19 68.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE42818.1 - 4.3e-14 52.2 0.0 1.2e-13 50.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE42818.1 - 3.2e-06 26.8 0.0 6.2e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 EFE42818.1 - 0.39 10.2 2.9 1.2 8.6 0.0 3.1 2 1 0 2 2 2 0 Ribonuclease B OB domain WD40 PF00400.27 EFE42819.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 WD domain, G-beta repeat Septin PF00735.13 EFE42820.1 - 1.2e-99 332.8 0.7 1.6e-99 332.4 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 EFE42820.1 - 0.0023 17.8 0.0 0.0048 16.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFE42820.1 - 0.018 14.8 2.8 0.4 10.4 0.0 3.0 2 1 1 3 3 3 0 Dynamin family GTP_EFTU PF00009.22 EFE42820.1 - 0.031 13.7 0.0 0.68 9.3 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF390 PF04094.9 EFE42820.1 - 0.035 12.1 4.4 0.051 11.6 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF390) FMN_bind PF04205.9 EFE42820.1 - 0.18 11.9 0.8 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 FMN-binding domain DUF3653 PF12375.3 EFE42820.1 - 0.38 11.0 2.9 8.5 6.6 1.1 2.9 2 1 0 2 2 2 0 Phage protein V_ATPase_I PF01496.14 EFE42820.1 - 7.9 4.2 6.6 12 3.5 4.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CNH PF00780.17 EFE42821.1 - 3.2e-82 276.0 0.0 1.6e-81 273.7 0.0 1.9 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.1 EFE42821.1 - 8.5e-39 132.5 0.0 1.9e-38 131.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.15 EFE42821.1 - 2.5e-38 131.7 0.0 4.4e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.16 EFE42821.1 - 6.1e-13 48.3 0.0 1.6e-12 47.0 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase PF00069.20 EFE42822.1 - 1.7e-57 194.5 0.0 3.1e-57 193.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42822.1 - 9.1e-31 106.8 0.0 6.3e-30 104.1 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE42822.1 - 4e-05 22.7 0.0 6.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.15 EFE42822.1 - 0.02 14.4 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase PyrBI_leader PF08052.6 EFE42822.1 - 0.032 14.0 0.1 4.3 7.2 0.0 2.4 2 0 0 2 2 2 0 PyrBI operon leader peptide Kdo PF06293.9 EFE42822.1 - 0.051 12.6 0.0 0.098 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE42822.1 - 0.066 12.9 0.0 0.18 11.5 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFE42822.1 - 0.2 10.4 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gly_transf_sug PF04488.10 EFE42823.1 - 1.7e-13 50.8 0.0 3.1e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EFE42823.1 - 0.26 9.7 0.0 1.1 7.7 0.0 1.8 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Abhydrolase_1 PF00561.15 EFE42824.1 - 2.3e-20 73.1 0.0 3.5e-19 69.2 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFE42824.1 - 2.9e-11 43.7 0.0 5.5e-08 32.9 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Esterase PF00756.15 EFE42824.1 - 0.00075 19.0 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase ThiF PF00899.16 EFE42825.1 - 1.1e-35 122.3 0.0 2.1e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 ThiF family Metallophos PF00149.23 EFE42825.1 - 3.1e-11 43.0 0.0 5.9e-10 38.8 0.0 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE42825.1 - 2.7e-09 37.0 0.0 5.5e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TrkA_N PF02254.13 EFE42825.1 - 0.019 14.9 0.0 0.07 13.1 0.0 2.0 1 0 0 1 1 1 0 TrkA-N domain Glyco_hydro_17 PF00332.13 EFE42825.1 - 0.033 13.2 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 ApbA PF02558.11 EFE42825.1 - 0.043 13.2 0.1 0.084 12.3 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Saccharop_dh PF03435.13 EFE42825.1 - 0.12 11.3 0.9 0.44 9.4 0.6 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase 3HCDH_N PF02737.13 EFE42825.1 - 0.13 11.9 0.0 0.38 10.3 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MARVEL PF01284.18 EFE42826.1 - 1.1e-16 61.0 7.6 1.4e-16 60.5 5.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain ABC2_membrane_5 PF13346.1 EFE42826.1 - 0.025 13.8 2.8 0.058 12.6 2.0 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF4336 PF14234.1 EFE42827.1 - 1.2e-16 60.8 0.3 1.3e-13 50.8 0.2 2.0 1 1 0 2 2 2 2 Domain of unknown function (DUF4336) DUF386 PF04074.7 EFE42827.1 - 0.096 12.1 0.0 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF386) Nse4_C PF08743.5 EFE42828.1 - 3.2e-32 110.3 0.0 7.3e-32 109.2 0.0 1.6 2 0 0 2 2 2 1 Nse4 C-terminal Aida_N PF08910.5 EFE42828.1 - 0.085 13.0 0.3 0.7 10.1 0.0 2.1 2 0 0 2 2 2 0 Aida N-terminus RD3 PF14473.1 EFE42828.1 - 0.12 11.8 0.2 0.22 11.0 0.2 1.4 1 0 0 1 1 1 0 RD3 protein PI3Ka PF00613.15 EFE42829.1 - 2.4e-59 199.6 0.2 3.7e-59 198.9 0.1 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 EFE42829.1 - 2.4e-43 148.2 0.0 1.6e-41 142.3 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 EFE42829.1 - 7.6e-29 100.3 0.0 1.2e-28 99.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 HCO3_cotransp PF00955.16 EFE42830.1 - 1.2e-39 136.3 13.7 3.4e-29 101.9 1.4 3.1 1 1 2 3 3 3 3 HCO3- transporter family MMR_HSR1 PF01926.18 EFE42831.1 - 6.6e-13 48.6 0.0 1.4e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFE42831.1 - 4.1e-05 22.8 0.0 7.1e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 EFE42831.1 - 0.00032 20.0 0.2 0.00084 18.6 0.1 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_15 PF13175.1 EFE42831.1 - 0.0043 16.1 0.0 0.0059 15.7 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain MobB PF03205.9 EFE42831.1 - 0.0049 16.5 0.0 0.0087 15.7 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 EFE42831.1 - 0.0059 16.9 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE42831.1 - 0.0087 16.8 0.0 0.021 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 EFE42831.1 - 0.017 14.5 0.0 0.058 12.8 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 EFE42831.1 - 0.02 15.0 0.0 0.41 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 EFE42831.1 - 0.028 14.9 0.0 0.059 13.8 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein ArgK PF03308.11 EFE42831.1 - 0.045 12.5 0.1 0.074 11.8 0.0 1.3 1 0 0 1 1 1 0 ArgK protein NTPase_1 PF03266.10 EFE42831.1 - 0.058 13.1 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 NTPase Arf PF00025.16 EFE42831.1 - 0.084 12.1 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Septin PF00735.13 EFE42831.1 - 0.12 11.4 0.0 0.25 10.3 0.0 1.5 2 0 0 2 2 2 0 Septin Isy1 PF06246.7 EFE42832.1 - 4.4e-85 285.1 0.0 5.8e-85 284.7 0.0 1.2 1 0 0 1 1 1 1 Isy1-like splicing family CAP59_mtransfer PF11735.3 EFE42833.1 - 4.1e-74 248.8 0.0 5.6e-74 248.4 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 RHH_1 PF01402.16 EFE42834.1 - 0.018 14.9 0.2 0.02 14.7 0.1 1.1 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family Suf PF05843.9 EFE42835.1 - 1.1 8.9 4.3 2.4 7.8 3.0 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GST_N PF02798.15 EFE42837.1 - 1.8e-12 47.2 0.0 4.9e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 EFE42837.1 - 8e-12 45.2 0.0 1.4e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE42837.1 - 1.1e-10 41.3 0.0 2.7e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFE42837.1 - 5.7e-10 39.0 0.0 1.4e-09 37.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE42837.1 - 2.6e-08 34.2 0.0 3.9e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFE42837.1 - 3.4e-06 26.8 0.0 7.6e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Swi3 PF07962.7 EFE42837.1 - 0.13 11.8 0.1 0.55 9.8 0.0 1.9 2 0 0 2 2 2 0 Replication Fork Protection Component Swi3 APH PF01636.18 EFE42838.1 - 1.1e-06 28.5 0.0 4.9e-05 23.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family HSDR_N PF04313.9 EFE42839.1 - 0.087 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF1762 PF08574.5 EFE42840.1 - 3.5e-10 40.1 8.7 4.3e-10 39.8 3.2 3.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1762) DUF179 PF02622.10 EFE42841.1 - 0.74 9.4 4.2 0.43 10.2 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized ACR, COG1678 DDHD PF02862.12 EFE42841.1 - 3.5 7.3 13.6 4.2 7.0 9.4 1.3 1 0 0 1 1 1 0 DDHD domain Mmp37 PF09139.6 EFE42841.1 - 4.5 6.1 9.8 5.6 5.8 6.8 1.1 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 DUF1800 PF08811.6 EFE42841.1 - 4.9 5.9 10.6 6.6 5.5 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) TB2_DP1_HVA22 PF03134.14 EFE42842.1 - 1.4e-19 69.6 4.2 2.3e-19 68.9 2.9 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family F-box-like PF12937.2 EFE42843.1 - 2.3e-05 24.0 0.1 5.1e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE42843.1 - 4.8e-05 22.9 0.2 0.00012 21.6 0.1 1.6 1 0 0 1 1 1 1 F-box domain PRANC PF09372.5 EFE42843.1 - 0.016 15.1 0.1 0.042 13.8 0.1 1.6 1 0 0 1 1 1 0 PRANC domain Peptidase_S32 PF05579.8 EFE42844.1 - 0.018 14.0 0.0 0.029 13.3 0.0 1.2 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Trypsin_2 PF13365.1 EFE42844.1 - 0.072 13.0 0.0 0.66 9.9 0.0 2.4 1 1 0 1 1 1 0 Trypsin-like peptidase domain Glyco_hydro_18 PF00704.23 EFE42847.1 - 6.1e-36 124.5 0.2 9.2e-36 123.9 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.15 EFE42847.1 - 1.3e-11 44.2 0.0 1.1e-07 31.5 0.0 2.7 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.14 EFE42847.1 - 1.2e-06 28.3 3.5 1.2e-06 28.3 2.5 2.9 3 0 0 3 3 3 1 Chitin recognition protein Peptidase_C1_2 PF03051.10 EFE42847.1 - 0.028 12.9 0.0 0.046 12.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase C1-like family YesK PF14150.1 EFE42848.1 - 0.023 14.7 0.2 0.041 13.9 0.1 1.4 1 0 0 1 1 1 0 YesK-like protein PHO4 PF01384.15 EFE42849.1 - 9.7e-98 326.7 17.4 1.2e-97 326.5 12.0 1.1 1 0 0 1 1 1 1 Phosphate transporter family Pkinase PF00069.20 EFE42851.1 - 4.3e-61 206.3 0.0 5.3e-61 206.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42851.1 - 1.4e-30 106.2 0.0 1.8e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE42851.1 - 5.6e-06 25.5 0.1 2e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE42851.1 - 0.00015 21.5 0.1 0.00094 18.9 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EFE42851.1 - 0.0011 17.9 0.1 0.0093 14.9 0.0 1.8 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.17 EFE42851.1 - 0.022 14.1 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.6 EFE42851.1 - 0.1 11.3 0.2 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FLO_LFY PF01698.11 EFE42852.1 - 0.048 12.5 10.0 0.07 11.9 6.9 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein VIT1 PF01988.14 EFE42852.1 - 0.1 12.0 6.6 0.46 9.9 4.6 1.8 1 1 0 1 1 1 0 VIT family Hid1 PF12722.2 EFE42852.1 - 0.68 7.5 4.7 0.82 7.2 3.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAPS PF04499.10 EFE42852.1 - 1.2 7.7 5.9 1.4 7.5 4.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PLRV_ORF5 PF01690.12 EFE42852.1 - 2.3 7.2 11.6 2.7 7.0 8.1 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein GAGA_bind PF06217.7 EFE42852.1 - 2.8 7.8 11.1 3.9 7.3 7.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Asp-B-Hydro_N PF05279.6 EFE42852.1 - 4.6 7.0 21.3 6 6.6 14.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region MIP-T3 PF10243.4 EFE42852.1 - 8 4.8 32.7 10 4.4 22.7 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 G-alpha PF00503.15 EFE42853.1 - 8.2e-42 143.2 0.0 1e-41 142.9 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit DAO PF01266.19 EFE42854.1 - 2e-06 27.0 0.0 3e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase TBP PF00352.16 EFE42855.1 - 2.4e-69 228.7 0.2 2.1e-34 116.7 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EFE42855.1 - 0.0001 22.2 0.0 0.44 10.6 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) ETF_QO PF05187.8 EFE42857.1 - 1.7e-45 153.5 0.0 2.7e-45 152.8 0.0 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 EFE42857.1 - 1.5e-05 24.1 0.0 0.014 14.3 0.0 2.9 3 0 0 3 3 3 2 FAD dependent oxidoreductase Fer4_7 PF12838.2 EFE42857.1 - 0.0058 16.9 1.1 0.014 15.7 0.8 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain NAD_binding_8 PF13450.1 EFE42857.1 - 0.0067 16.4 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain RRM_1 PF00076.17 EFE42858.1 - 8.8e-06 25.2 0.0 1.7e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE42858.1 - 0.00076 19.4 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE42858.1 - 0.082 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FolB PF02152.13 EFE42859.1 - 1e-22 80.4 0.2 4.3e-18 65.5 0.2 2.4 2 0 0 2 2 2 2 Dihydroneopterin aldolase AlphaC_N PF08829.5 EFE42859.1 - 0.082 12.2 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Alpha C protein N terminal Pkinase PF00069.20 EFE42860.1 - 4.6e-66 222.6 0.0 6.3e-66 222.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42860.1 - 1.2e-29 103.2 0.0 1.6e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE42860.1 - 0.032 13.9 0.9 2.1 8.0 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1950 PF09187.5 EFE42861.1 - 0.016 15.3 0.0 0.046 13.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function(DUF1950) DUF3446 PF11928.3 EFE42861.1 - 0.095 12.9 0.9 13 6.0 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) DUF2767 PF10965.3 EFE42861.1 - 0.11 12.3 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2767) Ndc80_HEC PF03801.8 EFE42862.1 - 8.4e-63 210.5 0.4 8.4e-63 210.5 0.3 1.7 2 0 0 2 2 2 1 HEC/Ndc80p family Pex14_N PF04695.8 EFE42863.1 - 4.2e-30 104.5 0.0 4.2e-30 104.5 0.0 2.9 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3584 PF12128.3 EFE42863.1 - 0.0041 14.5 2.7 0.0057 14.0 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) SYCE1 PF15233.1 EFE42863.1 - 0.21 11.5 2.4 0.37 10.7 1.7 1.3 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 ERM PF00769.14 EFE42863.1 - 3.6 7.0 11.4 8.8 5.7 7.9 1.9 1 1 0 1 1 1 0 Ezrin/radixin/moesin family IncA PF04156.9 EFE42863.1 - 5.2 6.6 10.9 17 4.9 7.5 1.8 1 1 0 1 1 1 0 IncA protein ABC_tran PF00005.22 EFE42865.1 - 1.3e-33 116.2 0.0 2.5e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EFE42865.1 - 1.2e-16 60.9 0.8 1.2e-16 60.9 0.6 2.4 2 1 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.14 EFE42865.1 - 2.9e-05 23.3 0.2 0.0019 17.4 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE42865.1 - 0.0002 21.4 0.0 0.16 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 EFE42865.1 - 0.0063 16.8 0.1 0.039 14.2 0.3 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EFE42865.1 - 0.011 15.2 0.3 0.031 13.8 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.1 EFE42865.1 - 0.014 15.3 0.1 0.079 12.8 0.0 2.4 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 EFE42865.1 - 0.04 14.0 0.0 0.14 12.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 EFE42865.1 - 0.043 13.0 0.0 0.087 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 TTL PF03133.10 EFE42866.1 - 1.1e-57 195.2 0.0 1.4e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 EFE42866.1 - 0.0078 15.0 0.0 0.015 14.1 0.0 1.4 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 EFE42866.1 - 0.016 14.9 0.1 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFE42866.1 - 0.026 13.9 0.1 0.44 9.8 0.0 2.2 1 1 1 2 2 2 0 D-ala D-ala ligase C-terminus SurE PF01975.12 EFE42867.1 - 5.2e-36 123.8 0.0 6.5e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE Seipin PF06775.9 EFE42868.1 - 4.1e-48 163.5 0.0 5e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Not1 PF04054.10 EFE42869.1 - 2.7e-135 451.0 0.7 2.7e-135 451.0 0.5 2.6 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 EFE42869.1 - 1.7e-50 170.4 1.2 4.6e-50 169.1 0.8 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) SH3_1 PF00018.23 EFE42870.1 - 6.6e-13 47.8 0.0 1.8e-12 46.4 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EFE42870.1 - 2.2e-10 39.8 0.0 8.6e-10 37.9 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.1 EFE42870.1 - 3.1e-10 39.4 0.0 1.2e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain FCH PF00611.18 EFE42870.1 - 0.0032 17.5 0.3 0.044 13.9 0.0 2.9 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DASH_Duo1 PF08651.5 EFE42871.1 - 4e-29 99.9 0.2 7.7e-29 99.0 0.2 1.5 1 0 0 1 1 1 1 DASH complex subunit Duo1 3HCDH_N PF02737.13 EFE42871.1 - 0.18 11.4 6.0 0.16 11.5 0.2 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain OmpH PF03938.9 EFE42871.1 - 0.73 9.7 15.6 0.33 10.8 1.5 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF745 PF05335.8 EFE42871.1 - 0.77 9.2 12.6 0.051 13.0 5.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF745) zf-primase PF09329.6 EFE42873.1 - 1.3e-19 69.5 0.6 2.4e-19 68.6 0.4 1.5 1 0 0 1 1 1 1 Primase zinc finger RNase_H2-Ydr279 PF09468.5 EFE42874.1 - 2.8e-88 296.0 2.7 4.2e-88 295.4 1.9 1.2 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) Selenoprotein_S PF06936.6 EFE42874.1 - 5.7 6.4 10.1 0.47 9.9 2.8 2.0 2 0 0 2 2 2 0 Selenoprotein S (SelS) GalKase_gal_bdg PF10509.4 EFE42875.1 - 3.2e-18 64.7 0.0 6.2e-18 63.8 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.8 EFE42875.1 - 1.4e-14 53.9 0.0 3.2e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 EFE42875.1 - 1.3e-12 47.5 0.7 4.8e-12 45.7 0.6 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain DED PF01335.16 EFE42875.1 - 0.16 12.0 1.7 0.45 10.6 0.1 2.3 3 0 0 3 3 3 0 Death effector domain TPP_enzyme_N PF02776.13 EFE42876.1 - 1.2e-55 187.6 0.1 9.6e-55 184.6 0.0 2.4 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EFE42876.1 - 2.3e-49 166.8 0.5 6.5e-47 158.9 0.0 3.0 3 1 0 3 3 3 2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EFE42876.1 - 1.5e-38 131.6 0.6 5.9e-38 129.7 0.1 2.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.14 EFE42876.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.5 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg RINGv PF12906.2 EFE42877.1 - 4.5e-06 26.5 5.4 1.2e-05 25.2 3.8 1.8 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.3 EFE42877.1 - 3.4e-05 23.7 2.9 8.5e-05 22.4 2.0 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.1 EFE42877.1 - 0.00089 19.0 3.8 0.002 17.9 2.7 1.6 1 0 0 1 1 1 1 Ring finger domain PhnA_Zn_Ribbon PF08274.7 EFE42877.1 - 0.0042 16.8 2.3 0.011 15.5 1.6 1.7 1 0 0 1 1 1 1 PhnA Zinc-Ribbon Ras PF00071.17 EFE42878.1 - 6.8e-31 106.8 0.0 7.7e-31 106.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE42878.1 - 7.1e-08 32.9 0.0 1e-07 32.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein hSH3 PF14603.1 EFE42879.1 - 0.092 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Helically-extended SH3 domain PGA2 PF07543.7 EFE42880.1 - 2.8 7.7 7.3 5.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 Acyl_transf_3 PF01757.17 EFE42881.1 - 1.1e-16 60.5 30.8 1.9e-16 59.8 21.3 1.4 1 1 0 1 1 1 1 Acyltransferase family Peptidase_S24 PF00717.18 EFE42883.1 - 3.5e-08 32.9 0.0 5.5e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like BTB PF00651.26 EFE42884.1 - 2e-06 27.7 0.0 7.2e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Sterol_MT_C PF08498.5 EFE42885.1 - 7.9e-21 73.7 0.2 1.3e-20 73.1 0.1 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 EFE42885.1 - 1.1e-15 57.8 0.0 2.3e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE42885.1 - 3e-14 52.8 0.0 7.4e-14 51.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE42885.1 - 1.2e-12 47.8 0.0 1.9e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE42885.1 - 4.4e-12 46.5 0.0 1e-11 45.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE42885.1 - 5.9e-10 39.5 0.0 1.5e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE42885.1 - 3.7e-09 36.0 0.0 3.4e-08 32.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 EFE42885.1 - 1e-08 34.6 0.1 5.4e-08 32.2 0.0 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 EFE42885.1 - 1.9e-08 34.5 0.0 3.5e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE42885.1 - 1.8e-05 24.7 0.0 6.4e-05 22.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EFE42885.1 - 0.00037 20.0 0.0 0.00071 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.5 EFE42885.1 - 0.0023 17.5 0.0 0.0047 16.4 0.0 1.5 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 EFE42885.1 - 0.0024 17.2 0.0 0.0061 15.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.8 EFE42885.1 - 0.093 11.8 0.0 0.21 10.6 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_29 PF03141.11 EFE42885.1 - 0.17 10.1 0.0 0.58 8.4 0.0 1.7 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase p450 PF00067.17 EFE42886.1 - 1e-25 90.2 0.0 1.3e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RCC1 PF00415.13 EFE42887.1 - 2.9e-46 155.4 0.0 6.3e-09 35.9 0.0 8.3 7 3 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EFE42887.1 - 7.9e-33 111.3 27.2 3.3e-07 29.7 0.4 6.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PilO PF04350.8 EFE42888.1 - 0.0044 16.9 0.9 0.011 15.5 0.2 1.9 1 1 1 2 2 2 1 Pilus assembly protein, PilO Baculo_PEP_C PF04513.7 EFE42888.1 - 0.016 15.0 0.7 0.016 15.0 0.5 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0184 PF03670.8 EFE42888.1 - 0.047 13.8 0.2 0.13 12.4 0.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF1401 PF07180.6 EFE42888.1 - 0.1 12.3 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1401) DUF2752 PF10825.3 EFE42888.1 - 0.13 12.3 1.6 0.22 11.6 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) eIF-3c_N PF05470.7 EFE42889.1 - 7.8 4.4 6.3 15 3.5 4.3 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Sds3 PF08598.6 EFE42893.1 - 2.7e-44 151.1 19.7 2.3e-43 148.1 13.6 2.0 1 1 0 1 1 1 1 Sds3-like RRF_GI PF12614.3 EFE42893.1 - 0.095 12.5 2.9 0.61 9.9 2.4 2.0 2 0 0 2 2 2 0 Ribosome recycling factor EZH2_WD-Binding PF11616.3 EFE42896.1 - 0.12 12.2 0.6 3.4 7.6 0.1 2.4 1 1 1 2 2 2 0 WD repeat binding protein EZH2 Phos_pyr_kin PF08543.7 EFE42898.1 - 1.5e-68 230.6 1.5 2.4e-68 229.9 1.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 EFE42898.1 - 1.9e-33 115.9 2.1 5.9e-21 75.1 0.1 2.3 1 1 1 2 2 2 2 TENA/THI-4/PQQC family PfkB PF00294.19 EFE42898.1 - 1.3e-06 27.8 0.2 1.9e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.10 EFE42898.1 - 0.0058 15.8 0.4 0.044 12.9 0.0 2.2 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family DEAD PF00270.24 EFE42899.1 - 3.5e-45 153.5 0.0 5.7e-44 149.5 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE42899.1 - 3.8e-09 36.2 0.0 1.1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE42899.1 - 0.00012 21.9 0.0 0.00044 20.1 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2443 PF10398.4 EFE42899.1 - 0.032 14.0 0.1 0.062 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) AAA_22 PF13401.1 EFE42899.1 - 0.38 10.9 1.3 5.6 7.1 0.2 2.8 1 1 0 2 2 2 0 AAA domain PPR_2 PF13041.1 EFE42900.1 - 1e-24 86.2 0.0 5.9e-17 61.3 0.0 3.1 2 1 1 3 3 3 3 PPR repeat family PPR_1 PF12854.2 EFE42900.1 - 2.2e-08 33.4 0.2 0.021 14.3 0.0 3.7 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.1 EFE42900.1 - 9e-08 31.8 0.5 0.0011 19.0 0.0 5.1 5 0 0 5 5 5 1 Pentatricopeptide repeat domain PPR PF01535.15 EFE42900.1 - 1.1e-05 25.0 5.4 0.0001 22.0 0.0 4.0 5 0 0 5 5 5 1 PPR repeat EPSP_synthase PF00275.15 EFE42901.1 - 2e-130 435.0 0.0 3.5e-130 434.2 0.0 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 EFE42901.1 - 1.4e-96 322.4 0.0 2.5e-96 321.6 0.0 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.10 EFE42901.1 - 7.9e-62 208.8 0.0 1.5e-61 207.9 0.0 1.5 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 EFE42901.1 - 3.6e-37 127.6 0.0 8.7e-37 126.4 0.0 1.7 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.6 EFE42901.1 - 1.4e-25 89.1 0.0 4e-25 87.6 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 EFE42901.1 - 4.7e-12 46.1 0.0 1.4e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.1 EFE42901.1 - 2.4e-08 33.6 0.0 7.3e-08 32.0 0.0 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_17 PF13207.1 EFE42901.1 - 0.013 16.2 0.1 0.082 13.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EFE42901.1 - 0.05 13.9 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFE42901.1 - 0.097 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFE42901.1 - 0.14 12.0 0.0 0.43 10.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain XRN_N PF03159.13 EFE42902.1 - 1.3e-105 352.0 0.0 1.3e-105 352.0 0.0 2.4 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus Uso1_p115_head PF04869.9 EFE42903.1 - 3e-111 371.1 0.1 4.4e-110 367.3 0.0 2.6 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.8 EFE42903.1 - 9.6e-05 22.3 32.9 9.6e-05 22.3 22.8 3.5 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2570 PF10828.3 EFE42903.1 - 0.0091 15.5 8.5 0.0091 15.5 5.9 3.7 2 1 2 4 4 4 2 Protein of unknown function (DUF2570) Spc7 PF08317.6 EFE42903.1 - 2.2 6.8 41.0 0.08 11.5 5.2 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Mgr1 PF08602.5 EFE42903.1 - 7.5 5.4 19.1 3.7 6.4 1.8 2.3 2 0 0 2 2 2 0 Mgr1-like, i-AAA protease complex subunit tRNA-synt_1 PF00133.17 EFE42904.1 - 2.5e-216 719.3 0.0 3.7e-216 718.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EFE42904.1 - 7.1e-25 87.5 0.0 2.2e-24 85.9 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EFE42904.1 - 1.7e-15 56.5 0.0 3.3e-06 26.0 0.0 3.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) p450 PF00067.17 EFE42905.1 - 1.8e-73 247.6 0.0 2.8e-73 247.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.15 EFE42905.1 - 5.4e-33 114.2 0.0 9.9e-33 113.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 EFE42905.1 - 4.4e-20 72.1 0.0 9.7e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EFE42905.1 - 1.2e-13 51.6 0.0 2.5e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 EFE42905.1 - 0.00059 19.8 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain NAD_binding_6 PF08030.7 EFE42905.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Sfi1 PF08457.5 EFE42906.1 - 8.3e-142 473.5 84.1 1.3e-140 469.6 53.2 2.0 1 1 1 2 2 2 2 Sfi1 spindle body protein DUF454 PF04304.8 EFE42906.1 - 0.017 15.1 0.4 3 7.9 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF454) Elongin_A PF06881.6 EFE42907.1 - 1.2e-23 83.5 1.9 2.2e-23 82.6 1.3 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.28 EFE42908.1 - 0.016 14.8 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.2 EFE42908.1 - 0.028 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 F-box-like Stc1 PF12898.2 EFE42908.1 - 0.095 12.7 1.0 0.24 11.4 0.7 1.7 1 0 0 1 1 1 0 Stc1 domain DUF2602 PF10782.4 EFE42908.1 - 8.9 6.2 7.9 1.8 8.4 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2602) Sugar_tr PF00083.19 EFE42910.1 - 7.5e-68 229.1 20.1 9.2e-68 228.8 14.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE42910.1 - 7.3e-09 34.7 26.4 6.4e-06 25.1 11.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily EBP PF05241.7 EFE42910.1 - 0.0065 15.5 2.6 0.0065 15.5 1.8 2.4 3 0 0 3 3 3 1 Emopamil binding protein Band_7 PF01145.20 EFE42911.1 - 3.2e-16 59.7 0.0 3.2e-16 59.7 0.0 2.5 2 1 0 2 2 2 1 SPFH domain / Band 7 family DUF4632 PF15451.1 EFE42912.1 - 0.4 10.6 3.7 0.5 10.3 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) TBCA PF02970.11 EFE42914.1 - 1.3e-24 86.0 12.2 1.6e-24 85.8 8.5 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A DUF2972 PF11186.3 EFE42914.1 - 0.039 13.8 1.3 0.048 13.5 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) D123 PF07065.9 EFE42914.1 - 0.046 12.7 1.7 0.049 12.7 1.2 1.1 1 0 0 1 1 1 0 D123 AdoMet_Synthase PF01941.14 EFE42914.1 - 0.054 12.0 0.2 0.095 11.1 0.1 1.4 1 1 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) IncA PF04156.9 EFE42914.1 - 0.099 12.2 13.2 0.12 11.9 9.1 1.1 1 0 0 1 1 1 0 IncA protein Exonuc_VII_L PF02601.10 EFE42914.1 - 0.15 11.2 7.8 0.17 11.0 5.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.14 EFE42914.1 - 0.15 9.8 5.1 0.17 9.7 3.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1993 PF09351.5 EFE42914.1 - 0.22 11.4 3.1 0.86 9.5 2.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) AAA_23 PF13476.1 EFE42914.1 - 0.26 11.5 10.9 0.35 11.1 7.6 1.2 1 0 0 1 1 1 0 AAA domain HSP70 PF00012.15 EFE42914.1 - 0.28 9.0 9.8 0.32 8.8 6.8 1.0 1 0 0 1 1 1 0 Hsp70 protein GCIP PF13324.1 EFE42914.1 - 0.41 9.8 4.6 0.44 9.7 3.2 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF342 PF03961.8 EFE42914.1 - 0.49 8.7 8.5 0.56 8.5 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Mnd1 PF03962.10 EFE42914.1 - 0.82 9.3 16.6 5.5 6.6 11.5 1.9 1 1 0 1 1 1 0 Mnd1 family Fib_alpha PF08702.5 EFE42914.1 - 1.8 8.6 7.1 2.4 8.2 4.7 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family EssA PF10661.4 EFE42914.1 - 2.2 7.9 9.3 2.8 7.6 6.5 1.0 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA HlyD PF00529.15 EFE42914.1 - 3.1 7.0 14.0 5.8 6.1 9.7 1.5 1 1 0 1 1 1 0 HlyD family secretion protein DUF2570 PF10828.3 EFE42914.1 - 4.6 6.8 8.1 6.3 6.4 5.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) CP12 PF02672.10 EFE42914.1 - 5.9 7.4 10.9 7.4 7.1 0.9 2.6 2 1 0 2 2 2 0 CP12 domain TMPIT PF07851.8 EFE42914.1 - 6 5.8 5.7 7.1 5.5 3.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein HAUS6_N PF14661.1 EFE42914.1 - 6.2 6.0 10.4 5.6 6.2 6.6 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TMF_DNA_bd PF12329.3 EFE42914.1 - 6.3 6.6 20.1 1.9 8.3 3.3 2.7 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding APG6 PF04111.7 EFE42914.1 - 8.5 5.3 12.7 11 5.0 8.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 HSCB_C PF07743.8 EFE42914.1 - 9.8 6.7 12.6 1.6 9.2 3.0 2.4 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain THOC7 PF05615.8 EFE42915.1 - 1.7e-38 132.0 9.6 1.7e-38 132.0 6.6 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 CCDC92 PF14916.1 EFE42915.1 - 0.0072 15.8 0.3 0.028 14.0 0.2 2.0 1 0 0 1 1 1 1 Coiled-coil domain of unknown function SSFA2_C PF14723.1 EFE42915.1 - 0.054 13.2 4.2 0.1 12.2 2.9 1.5 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus DUF1843 PF08898.5 EFE42915.1 - 0.12 12.4 0.5 0.12 12.4 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) zf-C4H2 PF10146.4 EFE42915.1 - 0.28 11.1 11.1 0.2 11.6 3.2 2.4 1 1 2 3 3 3 0 Zinc finger-containing protein CDC37_N PF03234.9 EFE42915.1 - 0.47 10.7 9.5 0.9 9.8 6.6 1.4 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding TEX19 PF15553.1 EFE42915.1 - 1.4 8.7 3.8 1.5 8.6 0.3 2.5 2 0 0 2 2 2 0 Testis-expressed protein 19 FUSC PF04632.7 EFE42915.1 - 1.7 7.0 7.6 2.2 6.5 5.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family SseC PF04888.7 EFE42915.1 - 3.4 6.9 5.4 21 4.2 1.5 2.3 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Bacillus_HBL PF05791.6 EFE42915.1 - 5.2 6.3 8.5 5.2 6.3 0.8 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.4 EFE42915.1 - 8.9 5.1 13.0 36 3.1 9.0 1.9 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 PTR2 PF00854.16 EFE42916.1 - 7.7e-55 186.1 13.7 1.3e-54 185.3 9.5 1.4 1 1 0 1 1 1 1 POT family DUF2730 PF10805.3 EFE42916.1 - 0.16 11.7 0.2 0.49 10.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Malic_M PF03949.10 EFE42917.1 - 2.5e-86 289.3 0.0 3.5e-86 288.9 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 EFE42917.1 - 2.4e-64 216.2 0.0 4.1e-64 215.5 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Kinesin PF00225.18 EFE42919.1 - 4.9e-53 179.9 0.0 1e-52 178.9 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain SAM_PNT PF02198.11 EFE42919.1 - 0.17 11.6 0.0 0.45 10.2 0.0 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DUF4449 PF14613.1 EFE42920.1 - 0.00066 19.6 0.1 0.00066 19.6 0.1 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) NAAA-beta PF15508.1 EFE42920.1 - 0.061 13.6 0.3 15 6.0 0.0 3.8 3 1 1 4 4 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Vfa1 PF08432.5 EFE42920.1 - 5.2 7.0 6.7 1.4 8.9 2.1 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DnaJ PF00226.26 EFE42921.1 - 2.4e-23 81.6 2.3 3.8e-23 80.9 1.6 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 EFE42921.1 - 9.5e-15 54.4 16.3 1.7e-14 53.6 11.3 1.4 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 EFE42921.1 - 6.8e-10 38.7 0.0 2.5e-09 36.8 0.0 2.0 2 0 0 2 2 2 1 DnaJ C terminal domain HypA PF01155.14 EFE42921.1 - 0.26 10.9 6.5 1.1 8.9 0.3 2.2 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family DZR PF12773.2 EFE42921.1 - 4.1 7.2 12.2 1.8e+02 2.0 8.5 2.2 1 1 0 1 1 1 0 Double zinc ribbon DIPSY PF11763.3 EFE42922.1 - 0.14 11.9 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Cell-wall adhesin ligand-binding C-terminal ADH_zinc_N PF00107.21 EFE42923.1 - 7.5e-08 31.9 0.0 1.4e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE42923.1 - 6.2e-05 22.7 0.4 0.00014 21.6 0.3 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EFE42923.1 - 0.023 15.5 0.0 0.051 14.4 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase S4 PF01479.20 EFE42924.1 - 7.4e-11 41.3 0.0 1.3e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 S4 domain PilP PF04351.8 EFE42924.1 - 0.031 14.1 0.0 0.048 13.5 0.0 1.4 1 0 0 1 1 1 0 Pilus assembly protein, PilP MFS_1 PF07690.11 EFE42926.1 - 3.2e-32 111.6 25.8 4.4e-32 111.1 17.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_16 PF00722.16 EFE42927.1 - 9.2e-44 148.9 0.4 9.2e-44 148.9 0.2 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Pkinase PF00069.20 EFE42928.1 - 3.3e-09 36.2 0.0 4.6e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42928.1 - 0.003 16.6 0.0 0.0042 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE42928.1 - 0.0091 15.0 0.0 0.016 14.2 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE42928.1 - 0.057 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EFE42928.1 - 0.069 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL tRNA-synt_1b PF00579.20 EFE42929.1 - 1.3e-65 221.4 0.0 1.9e-65 220.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) LRR_4 PF12799.2 EFE42930.1 - 6.2e-56 185.2 61.2 4.7e-09 35.6 1.3 12.9 8 2 5 13 13 13 11 Leucine Rich repeats (2 copies) PP2C PF00481.16 EFE42930.1 - 1.2e-53 182.1 0.0 1.8e-53 181.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.1 EFE42930.1 - 3.8e-44 148.2 63.5 3.1e-11 42.8 5.0 10.5 5 3 6 11 11 11 10 Leucine rich repeat Guanylate_cyc PF00211.15 EFE42930.1 - 3e-27 95.1 0.0 7.1e-27 93.9 0.0 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 EFE42930.1 - 4.8e-24 80.6 59.6 0.033 14.1 0.1 18.7 18 1 0 18 18 18 8 Leucine Rich Repeat LRR_7 PF13504.1 EFE42930.1 - 2.2e-11 41.9 59.7 0.55 10.6 0.2 16.6 17 0 0 17 17 16 5 Leucine rich repeat RA PF00788.18 EFE42930.1 - 1.1e-08 35.4 0.0 3.2e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Ad_cyc_g-alpha PF08509.6 EFE42930.1 - 2.3e-07 30.0 0.0 2.3e-07 30.0 0.0 2.9 4 0 0 4 4 3 1 Adenylate cyclase G-alpha binding domain LRR_5 PF13306.1 EFE42930.1 - 4e-06 26.5 4.6 0.03 14.0 0.2 4.0 3 1 0 4 4 4 2 Leucine rich repeats (6 copies) LRR_6 PF13516.1 EFE42930.1 - 5.5e-06 25.9 55.4 2.1 8.7 0.1 15.9 20 0 0 20 20 17 4 Leucine Rich repeat LRR_9 PF14580.1 EFE42930.1 - 1.8e-05 24.3 10.8 0.19 11.2 0.0 4.3 2 1 1 4 4 4 3 Leucine-rich repeat MSC PF09402.5 EFE42931.1 - 1e-92 310.4 0.0 1.4e-92 310.0 0.0 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.2 EFE42931.1 - 3.3e-16 58.5 0.2 6.8e-16 57.5 0.1 1.6 1 0 0 1 1 1 1 HeH/LEM domain DUF3632 PF12311.3 EFE42932.1 - 1e-11 44.9 0.1 1.5e-07 31.4 0.0 3.3 2 1 0 2 2 2 2 Protein of unknown function (DUF3632) SpoVAD PF07451.6 EFE42932.1 - 0.16 10.4 0.0 0.23 9.8 0.0 1.1 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Pox_Ag35 PF03286.9 EFE42932.1 - 0.57 9.6 8.0 0.24 10.9 0.1 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein UCH_1 PF13423.1 EFE42933.1 - 1e-74 251.6 1.2 1.4e-74 251.2 0.8 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 EFE42933.1 - 8.8e-19 68.3 0.0 6.6e-17 62.2 0.0 2.5 2 0 0 2 2 2 1 Exonuclease UCH PF00443.24 EFE42933.1 - 3e-05 23.2 0.0 0.00021 20.4 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase KH_1 PF00013.24 EFE42934.1 - 1.1e-90 297.2 8.4 4.6e-12 45.4 0.1 13.0 13 1 0 13 13 13 8 KH domain KH_3 PF13014.1 EFE42934.1 - 4.2e-66 217.7 13.3 2e-08 33.6 0.1 11.9 13 0 0 13 13 13 8 KH domain KH_2 PF07650.12 EFE42934.1 - 4.7e-10 38.8 14.5 0.0024 17.3 0.0 7.4 8 1 0 8 8 8 4 KH domain SLS PF14611.1 EFE42934.1 - 7.5e-10 38.5 1.1 0.027 13.8 0.0 6.7 6 3 1 7 7 7 3 Mitochondrial inner-membrane-bound regulator BMC PF00936.14 EFE42934.1 - 0.021 14.5 5.8 0.72 9.5 0.2 5.2 5 0 0 5 5 5 0 BMC domain CDK2AP PF09806.4 EFE42934.1 - 0.15 12.2 4.5 0.72 10.0 3.1 2.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein eIF3_N PF09440.5 EFE42934.1 - 0.21 11.7 1.1 1.4 9.0 0.1 2.8 3 0 0 3 3 3 0 eIF3 subunit 6 N terminal domain KH_5 PF13184.1 EFE42934.1 - 0.22 11.3 8.8 12 5.8 0.2 5.5 6 0 0 6 6 6 0 NusA-like KH domain Pkinase PF00069.20 EFE42935.1 - 4.5e-68 229.1 0.1 7.4e-68 228.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42935.1 - 2.7e-44 151.2 0.0 5.2e-44 150.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 EFE42935.1 - 5.9e-21 74.6 0.4 2e-20 72.9 0.3 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.1 EFE42935.1 - 3.1e-06 26.3 0.0 5.5e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE42935.1 - 0.027 14.2 0.1 0.27 10.9 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.7 EFE42935.1 - 0.039 13.1 1.2 0.063 12.5 0.0 1.9 3 0 0 3 3 3 0 DSHCT (NUC185) domain Kdo PF06293.9 EFE42935.1 - 0.11 11.5 0.1 0.2 10.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_1 PF00018.23 EFE42936.1 - 1.8e-17 62.4 0.1 8.3e-17 60.3 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 EFE42936.1 - 2.6e-16 58.9 0.2 4.8e-16 58.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFE42936.1 - 9.1e-14 50.6 0.1 2.2e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain UIM PF02809.15 EFE42936.1 - 0.021 14.3 0.9 0.049 13.2 0.6 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF4598 PF15370.1 EFE42936.1 - 0.033 14.4 0.1 0.085 13.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) DUF775 PF05603.7 EFE42936.1 - 0.13 11.7 2.5 0.1 12.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF775) K_trans PF02705.11 EFE42937.1 - 2e-149 498.3 20.1 3.5e-116 388.6 8.7 3.0 2 1 0 2 2 2 2 K+ potassium transporter Cyt-b5 PF00173.23 EFE42938.1 - 3.2e-26 90.9 0.0 4.1e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain GTP_EFTU PF00009.22 EFE42939.1 - 7.9e-52 175.4 0.0 1.8e-51 174.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.5 EFE42939.1 - 2.7e-20 72.2 9.8 5.2e-20 71.3 6.8 1.5 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.12 EFE42939.1 - 9.6e-09 35.3 0.0 2.5e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFE42939.1 - 1.2e-08 34.9 0.0 5e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFE42939.1 - 1.1e-07 31.7 0.0 3.8e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 EFE42939.1 - 7.3e-05 22.0 0.1 0.027 13.7 0.0 2.5 1 1 1 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 EFE42939.1 - 0.00035 21.0 0.0 0.0019 18.6 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein Ras PF00071.17 EFE42939.1 - 0.00061 19.2 0.2 0.013 14.8 0.0 2.3 1 1 1 2 2 2 1 Ras family FeoB_N PF02421.13 EFE42939.1 - 0.00063 19.0 0.2 0.031 13.5 0.1 3.2 3 1 0 3 3 3 1 Ferrous iron transport protein B SRPRB PF09439.5 EFE42939.1 - 0.0029 16.8 0.1 0.86 8.7 0.0 2.5 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit MobB PF03205.9 EFE42939.1 - 0.031 13.9 0.1 0.13 11.9 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B EST1 PF10374.4 EFE42939.1 - 0.1 12.5 1.5 0.57 10.1 0.6 2.2 2 0 0 2 2 2 0 Telomerase activating protein Est1 G-alpha PF00503.15 EFE42939.1 - 8.5 4.9 10.7 0.1 11.2 0.1 2.8 3 1 1 4 4 3 0 G-protein alpha subunit HSP70 PF00012.15 EFE42940.1 - 4.1e-251 834.1 14.5 8.9e-251 833.0 10.1 1.4 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFE42940.1 - 1.9e-17 62.8 0.6 3.1e-17 62.1 0.4 1.2 1 0 0 1 1 1 1 MreB/Mbl protein DDR PF08841.5 EFE42940.1 - 0.0042 15.9 0.8 0.037 12.8 0.2 2.2 2 1 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 EFE42940.1 - 0.015 14.4 0.8 0.17 10.9 0.1 2.3 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase FGGY_C PF02782.11 EFE42940.1 - 0.044 13.3 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain UCH PF00443.24 EFE42941.1 - 1.6e-58 197.9 0.1 2.5e-58 197.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE42941.1 - 2.7e-26 92.6 0.0 6.3e-26 91.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 EFE42941.1 - 0.0021 18.3 0.0 0.0055 17.0 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Rep_fac-A_C PF08646.5 EFE42941.1 - 6.3 6.5 5.7 19 4.9 1.4 2.8 2 1 1 3 3 3 0 Replication factor-A C terminal domain VHS PF00790.14 EFE42942.1 - 3.4e-42 143.4 0.4 7e-42 142.3 0.2 1.5 1 0 0 1 1 1 1 VHS domain UIM PF02809.15 EFE42942.1 - 0.0046 16.4 1.1 0.0046 16.4 0.8 3.1 3 0 0 3 3 3 2 Ubiquitin interaction motif TCO89 PF10452.4 EFE42943.1 - 0.00075 18.5 1.5 0.00075 18.5 1.1 3.2 2 1 1 3 3 3 2 TORC1 subunit TCO89 RCC1 PF00415.13 EFE42944.1 - 7.4e-25 86.9 0.2 9.8e-07 28.8 0.0 5.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 EFE42944.1 - 8.1e-14 51.5 0.2 3.1e-08 33.5 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.1 EFE42944.1 - 6.1e-09 35.2 2.2 1.4e-07 30.8 0.0 3.8 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.1 EFE42944.1 - 1.6e-06 28.4 0.7 0.00054 20.4 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE42944.1 - 0.0086 16.2 0.1 0.44 10.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.2 EFE42944.1 - 0.011 16.0 0.0 4.1 7.8 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFE42944.1 - 0.014 15.6 0.0 0.42 10.9 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.25 EFE42944.1 - 0.06 13.1 0.1 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeat ATG13 PF10033.4 EFE42945.1 - 1.3e-62 211.3 0.0 2.3e-62 210.5 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 13 FAD_binding_4 PF01565.18 EFE42946.1 - 1.5e-24 86.0 0.5 2.9e-24 85.1 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE42946.1 - 9.2e-06 25.4 0.1 2.3e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like Rieske PF00355.21 EFE42946.1 - 0.063 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain SET PF00856.23 EFE42947.1 - 7e-15 55.7 1.1 9.1e-14 52.0 0.0 3.1 2 2 0 2 2 2 1 SET domain TPR_11 PF13414.1 EFE42947.1 - 3e-11 42.7 4.6 8.2e-07 28.5 0.4 2.6 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EFE42947.1 - 0.00026 20.6 6.1 0.035 14.0 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFE42947.1 - 0.0012 18.3 3.9 0.31 10.7 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE42947.1 - 0.0023 18.5 2.8 0.35 11.5 0.1 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFE42947.1 - 0.007 16.9 0.1 0.063 13.9 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE42947.1 - 0.02 14.6 4.3 1.2 9.0 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFE42947.1 - 0.038 13.9 1.9 0.11 12.4 1.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat NUC153 PF08159.7 EFE42949.1 - 8.1e-11 41.3 0.3 1.8e-10 40.2 0.2 1.5 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.27 EFE42949.1 - 9.1e-06 25.3 0.1 0.11 12.4 0.0 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat AbrB-like PF14250.1 EFE42949.1 - 0.022 14.6 0.0 8.1 6.4 0.0 2.6 2 0 0 2 2 2 0 AbrB-like transcriptional regulator Auxin_repressed PF05564.7 EFE42949.1 - 0.83 10.2 7.8 0.38 11.3 3.3 2.0 2 0 0 2 2 2 0 Dormancy/auxin associated protein Med13_C PF06333.7 EFE42950.1 - 7.2e-73 245.5 1.5 4.9e-53 180.1 0.0 2.5 1 1 1 2 2 2 2 Mediator complex subunit 13 C-terminal Med13_N PF11597.3 EFE42950.1 - 5.8e-27 94.3 0.0 1.5e-26 93.0 0.0 1.7 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal DUF1098 PF06497.6 EFE42951.1 - 0.012 15.6 0.5 0.053 13.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1098) ERM PF00769.14 EFE42953.1 - 5.1 6.5 79.8 0.23 10.9 13.9 4.3 2 1 0 3 3 3 0 Ezrin/radixin/moesin family Shisa PF13908.1 EFE42955.1 - 0.0019 18.3 0.3 0.0026 17.9 0.2 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Collagen PF01391.13 EFE42955.1 - 0.018 14.5 3.8 0.087 12.3 1.1 2.2 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) CD99L2 PF12301.3 EFE42955.1 - 0.026 14.2 0.7 0.041 13.5 0.1 1.6 2 0 0 2 2 2 0 CD99 antigen like protein 2 Sigma_reg_N PF13800.1 EFE42955.1 - 0.049 13.6 0.2 0.076 13.0 0.1 1.2 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Cellulase PF00150.13 EFE42956.1 - 2.5e-07 30.1 3.5 1.2e-06 27.9 2.5 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) EphA2_TM PF14575.1 EFE42956.1 - 0.96 9.8 4.8 12 6.3 0.0 4.0 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Pkinase PF00069.20 EFE42957.1 - 9.1e-50 169.2 0.0 4.3e-47 160.4 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE42957.1 - 1.2e-24 86.8 0.0 4.8e-23 81.5 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE42957.1 - 1.2e-05 24.3 0.0 2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE42957.1 - 0.011 15.5 1.9 0.014 15.1 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 EFE42957.1 - 0.033 13.2 0.1 0.057 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF605 PF04652.11 EFE42957.1 - 6.7 6.0 18.8 9.2 5.5 13.0 1.1 1 0 0 1 1 1 0 Vta1 like SNF2_N PF00176.18 EFE42958.1 - 1.2e-74 250.7 0.0 5.8e-74 248.5 0.0 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE42958.1 - 9.3e-11 41.4 0.0 2.7e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD_2 PF06733.10 EFE42958.1 - 0.0089 15.4 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 PP2C_C PF07830.8 EFE42958.1 - 0.073 13.1 0.4 2.4 8.3 0.0 3.1 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain PALP PF00291.20 EFE42959.1 - 1.8e-39 135.7 0.1 4.6e-28 98.3 0.0 2.2 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme MFS_1 PF07690.11 EFE42960.1 - 1.3e-24 86.5 68.2 7.3e-24 84.1 34.4 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 EFE42961.1 - 1.1e-36 126.2 19.4 8e-21 74.1 2.7 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFE42961.1 - 1.4e-08 33.6 24.4 0.0072 14.7 3.6 3.1 3 0 0 3 3 3 3 MFS/sugar transport protein Sugar_tr PF00083.19 EFE42961.1 - 1.3e-05 23.9 24.2 0.00077 18.1 8.0 3.1 2 2 1 3 3 3 3 Sugar (and other) transporter MFS_1_like PF12832.2 EFE42961.1 - 0.002 17.9 7.8 0.0053 16.5 0.8 3.0 3 0 0 3 3 3 1 MFS_1 like family MFS_3 PF05977.8 EFE42961.1 - 0.29 9.2 22.2 0.015 13.4 3.7 2.5 3 0 0 3 3 3 0 Transmembrane secretion effector CoA_binding_3 PF13727.1 EFE42961.1 - 2.1 8.1 9.1 0.43 10.4 3.1 2.2 2 0 0 2 2 2 0 CoA-binding domain DUF3938 PF13074.1 EFE42961.1 - 2.4 8.0 5.9 6.3 6.7 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) SIR2 PF02146.12 EFE42962.1 - 5e-37 127.3 0.0 4.1e-36 124.3 0.0 1.9 1 1 0 1 1 1 1 Sir2 family Pyridox_ox_2 PF12900.2 EFE42963.1 - 5.6e-38 129.9 0.0 8.7e-38 129.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase ADH_zinc_N PF00107.21 EFE42964.1 - 8.4e-23 80.3 0.0 1.9e-22 79.2 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFE42964.1 - 1.9e-11 44.9 0.0 3.8e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE42964.1 - 4.8e-07 29.5 0.0 1.3e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain FR47 PF08445.5 EFE42965.1 - 2.3e-09 36.8 0.1 5.8e-05 22.7 0.0 2.4 1 1 1 2 2 2 2 FR47-like protein Acetyltransf_3 PF13302.1 EFE42965.1 - 8.4e-08 32.4 0.0 2.2e-07 31.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFE42965.1 - 9.8e-05 22.4 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE42965.1 - 0.00047 20.1 0.2 0.0034 17.3 0.1 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.1 EFE42965.1 - 0.071 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Peptidase_M24 PF00557.19 EFE42966.1 - 1.1e-44 152.5 0.0 2.3e-44 151.4 0.0 1.6 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.11 EFE42966.1 - 9.3e-13 47.7 0.0 1.5e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Dfp1_Him1_M PF08630.5 EFE42967.1 - 3.4e-36 123.7 0.0 8.4e-36 122.5 0.0 1.7 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.7 EFE42967.1 - 2.8e-06 26.8 3.0 6.4e-06 25.7 2.1 1.6 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.21 EFE42967.1 - 0.0008 19.5 0.0 0.0024 17.9 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EFE42967.1 - 0.0086 15.9 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain Pantoate_transf PF02548.10 EFE42968.1 - 4.6e-106 353.7 1.2 5.5e-106 353.4 0.8 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 EFE42968.1 - 3.2e-11 42.9 1.0 5.5e-11 42.1 0.7 1.5 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Peptidase_M20 PF01546.23 EFE42968.1 - 0.14 11.6 0.8 9.8 5.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase family M20/M25/M40 UQ_con PF00179.21 EFE42969.1 - 0.0003 20.2 0.0 0.00035 20.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LAMTOR PF15454.1 EFE42970.1 - 1.9e-18 66.5 1.2 2.9e-18 65.9 0.0 1.8 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF2011 PF09428.5 EFE42971.1 - 4.8e-42 142.9 5.3 4.8e-42 142.9 3.7 1.8 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF2011) D123 PF07065.9 EFE42973.1 - 0.00048 19.3 0.0 0.0021 17.1 0.0 1.9 1 1 0 1 1 1 1 D123 DUF4343 PF14243.1 EFE42973.1 - 0.016 15.0 0.0 0.045 13.6 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4343) Sulfotransfer_3 PF13469.1 EFE42974.1 - 0.08 13.8 0.0 0.3 12.0 0.0 1.9 1 1 0 1 1 1 0 Sulfotransferase family Cerato-platanin PF07249.7 EFE42975.1 - 1.4e-43 147.7 0.3 2e-43 147.1 0.2 1.2 1 0 0 1 1 1 1 Cerato-platanin Barwin PF00967.12 EFE42975.1 - 0.032 13.8 0.1 0.061 12.9 0.0 1.4 2 0 0 2 2 2 0 Barwin family GLTT PF01744.15 EFE42975.1 - 1.6 8.2 4.0 0.62 9.5 0.5 1.9 2 0 0 2 2 2 0 GLTT repeat (6 copies) MFS_1 PF07690.11 EFE42976.1 - 5.8e-46 156.8 45.3 5.8e-46 156.8 31.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE42976.1 - 4.3e-15 55.2 15.9 4.3e-15 55.2 11.0 3.5 2 1 0 3 3 3 2 Sugar (and other) transporter RICTOR_V PF14668.1 EFE42976.1 - 0.0066 16.3 0.0 0.023 14.6 0.0 2.0 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, domain 5 Flavoprotein PF02441.14 EFE42977.1 - 1.3e-10 41.0 0.0 2.3e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Flavoprotein Dimer_Tnp_hAT PF05699.9 EFE42977.1 - 0.11 12.0 1.1 4.8 6.8 0.0 3.4 4 0 0 4 4 4 0 hAT family C-terminal dimerisation region Peptidase_S8 PF00082.17 EFE42978.1 - 6.6e-44 150.1 10.1 8.8e-44 149.7 7.0 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE42978.1 - 4.4e-17 62.4 0.0 7.7e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 p450 PF00067.17 EFE42979.1 - 3.2e-62 210.5 0.0 3.9e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Asparaginase_2 PF01112.13 EFE42980.1 - 2.2e-38 131.7 0.0 2.1e-37 128.5 0.0 2.4 1 1 0 1 1 1 1 Asparaginase Tim17 PF02466.14 EFE42981.1 - 2.2e-29 102.0 5.1 2.7e-29 101.7 3.5 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MOSC_N PF03476.11 EFE42982.1 - 5.3e-09 35.8 0.0 2.9e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 EFE42982.1 - 2.9e-05 23.5 0.0 4.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 MOSC domain Amidase PF01425.16 EFE42983.1 - 3.5e-69 233.7 0.0 5.2e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 Amidase Rad51 PF08423.6 EFE42984.1 - 3e-08 32.9 0.0 3.1e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 EFE42984.1 - 1.2e-06 28.0 0.1 3.5e-05 23.2 0.0 2.8 3 1 0 3 3 3 1 AAA domain KaiC PF06745.8 EFE42984.1 - 5e-05 22.5 0.0 0.00015 20.9 0.0 1.8 2 0 0 2 2 2 1 KaiC RecA PF00154.16 EFE42984.1 - 0.00013 21.1 0.0 0.00022 20.4 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein PhoH PF02562.11 EFE42984.1 - 0.00037 19.7 0.0 0.0006 19.1 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.12 EFE42984.1 - 0.002 17.6 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein ABC_tran PF00005.22 EFE42984.1 - 0.0078 16.5 0.9 0.033 14.4 0.0 2.1 2 0 0 2 2 2 1 ABC transporter Zot PF05707.7 EFE42984.1 - 0.0094 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_10 PF12846.2 EFE42984.1 - 0.015 14.7 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain Arch_ATPase PF01637.13 EFE42984.1 - 0.016 14.9 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase RNA12 PF10443.4 EFE42984.1 - 0.04 12.4 1.2 0.061 11.8 0.0 1.8 3 0 0 3 3 3 0 RNA12 protein AAA_16 PF13191.1 EFE42984.1 - 0.066 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 EFE42984.1 - 0.098 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cyt-b5 PF00173.23 EFE42985.1 - 2.6e-17 62.3 0.0 6.1e-17 61.2 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 EFE42985.1 - 3e-17 62.9 12.9 5.9e-17 61.9 8.9 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Peptidase_M3 PF01432.15 EFE42986.1 - 4.2e-165 550.2 0.3 5.6e-165 549.8 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M3 Nop14 PF04147.7 EFE42987.1 - 0.00029 18.9 5.3 0.00033 18.7 3.7 1.1 1 0 0 1 1 1 1 Nop14-like family Nucleoplasmin PF03066.10 EFE42987.1 - 0.0017 17.8 3.4 0.0026 17.2 2.3 1.4 1 0 0 1 1 1 1 Nucleoplasmin BSP_II PF05432.6 EFE42987.1 - 0.011 15.0 11.0 0.022 14.0 7.6 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2890 PF11081.3 EFE42987.1 - 0.013 15.5 7.9 0.013 15.5 5.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) Daxx PF03344.10 EFE42987.1 - 0.029 12.8 8.6 0.046 12.2 6.0 1.3 1 0 0 1 1 1 0 Daxx Family YABBY PF04690.8 EFE42987.1 - 0.033 14.4 0.5 14 5.8 0.0 2.5 2 1 0 2 2 2 0 YABBY protein Yippee-Mis18 PF03226.9 EFE42987.1 - 0.068 13.2 0.0 8.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2197 PF09963.4 EFE42987.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) Mu-like_Com PF10122.4 EFE42987.1 - 0.11 11.6 0.5 2.5 7.2 0.1 2.4 2 0 0 2 2 2 0 Mu-like prophage protein Com CDC45 PF02724.9 EFE42987.1 - 0.19 9.7 7.0 0.25 9.3 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.1 EFE42987.1 - 0.66 10.3 6.2 0.47 10.7 2.5 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.17 EFE42987.1 - 0.67 8.8 2.5 0.8 8.6 1.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TRAP_alpha PF03896.11 EFE42987.1 - 0.86 8.5 5.0 1.3 8.0 3.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit VID27 PF08553.5 EFE42987.1 - 0.96 7.5 7.8 1.3 7.1 5.4 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein PI3K_1B_p101 PF10486.4 EFE42987.1 - 1.9 5.9 5.4 2.7 5.4 3.8 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FAM176 PF14851.1 EFE42987.1 - 2.7 7.6 6.5 1.5 8.4 3.1 1.7 2 0 0 2 2 2 0 FAM176 family zf-DHHC PF01529.15 EFE42987.1 - 4.5 6.6 9.4 0.17 11.2 0.4 2.1 1 1 1 2 2 2 0 DHHC palmitoyltransferase Pox_RNA_Pol_19 PF05320.7 EFE42987.1 - 5.9 6.6 9.4 11 5.7 6.5 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit CobT PF06213.7 EFE42987.1 - 6.6 5.7 14.6 10 5.1 10.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT EF-hand_7 PF13499.1 EFE42988.1 - 6.2e-13 48.6 0.0 6.2e-09 35.8 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 EFE42988.1 - 5e-10 38.4 0.1 0.0017 18.0 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_9 PF14658.1 EFE42988.1 - 8.2e-10 38.4 0.0 0.00013 21.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 EFE42988.1 - 4.2e-08 31.9 0.1 0.0098 15.1 0.0 3.4 3 1 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 EFE42988.1 - 8.4e-07 28.5 0.1 0.00065 19.2 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair UPF0154 PF03672.8 EFE42988.1 - 0.057 13.0 0.0 0.13 11.9 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF3216 PF11505.3 EFE42988.1 - 0.078 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) EF-hand_5 PF13202.1 EFE42988.1 - 0.082 12.2 0.4 3.7 7.0 0.1 3.0 2 0 0 2 2 2 0 EF hand Fungal_trans PF04082.13 EFE42989.1 - 4.3e-60 202.7 0.7 1.1e-59 201.4 0.4 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EFE42989.1 - 0.00028 21.0 14.9 0.0035 17.5 2.8 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE42989.1 - 0.00049 20.2 14.5 0.0038 17.4 1.9 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFE42989.1 - 0.091 13.0 10.4 0.17 12.2 2.1 2.7 2 0 0 2 2 2 0 Zinc-finger double domain Herpes_DNAp_acc PF04929.7 EFE42989.1 - 8.6 5.2 11.0 18 4.1 7.6 1.4 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Glyco_transf_90 PF05686.7 EFE42991.1 - 3.4e-13 49.0 1.3 3.7e-12 45.6 0.5 2.6 2 1 0 2 2 2 1 Glycosyl transferase family 90 Xpo1 PF08389.7 EFE42992.1 - 1.2e-22 80.3 0.2 3.1e-21 75.8 0.1 3.2 2 0 0 2 2 2 1 Exportin 1-like protein HEAT PF02985.17 EFE42992.1 - 0.0047 16.9 0.0 3.8 7.8 0.0 4.0 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.1 EFE42992.1 - 0.0056 16.9 0.0 0.027 14.7 0.0 2.2 1 0 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.1 EFE42992.1 - 0.011 16.2 0.0 0.24 11.9 0.0 3.5 2 1 1 3 3 3 0 HEAT-like repeat 5-FTHF_cyc-lig PF01812.15 EFE42993.1 - 7.5e-19 68.2 0.0 2.1e-18 66.7 0.0 1.7 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family CcmD PF04995.9 EFE42993.1 - 0.047 13.4 0.5 0.11 12.2 0.3 1.6 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) AA_permease_N PF08403.5 EFE42993.1 - 0.099 11.9 1.9 0.11 11.8 0.1 1.9 2 0 0 2 2 2 0 Amino acid permease N-terminal Nucleoplasmin PF03066.10 EFE42994.1 - 0.023 14.2 2.1 0.028 13.9 1.5 1.1 1 0 0 1 1 1 0 Nucleoplasmin EBV-NA3 PF05009.7 EFE42994.1 - 0.023 13.9 2.8 0.028 13.7 1.9 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF3357 PF11837.3 EFE42994.1 - 0.047 13.5 0.1 0.059 13.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) FAM176 PF14851.1 EFE42994.1 - 0.084 12.5 1.4 0.11 12.1 1.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF1676 PF07898.8 EFE42994.1 - 0.26 11.6 2.0 0.34 11.2 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DDHD PF02862.12 EFE42994.1 - 0.46 10.2 3.7 0.47 10.2 2.5 1.1 1 0 0 1 1 1 0 DDHD domain Voldacs PF03517.8 EFE42994.1 - 0.69 9.7 4.3 3.1 7.6 3.0 1.8 1 1 0 1 1 1 0 Regulator of volume decrease after cellular swelling DUF3484 PF11983.3 EFE42994.1 - 1.6 9.6 7.2 2.1 9.2 4.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3484) Rot1 PF10681.4 EFE42995.1 - 1.6e-80 269.4 0.3 3.5e-75 252.0 0.0 2.0 2 0 0 2 2 2 2 Chaperone for protein-folding within the ER, fungal YqeY PF09424.5 EFE42996.1 - 2.1e-21 76.2 5.6 2.6e-21 76.0 3.9 1.1 1 0 0 1 1 1 1 Yqey-like protein Nucleoporin_C PF03177.9 EFE42997.1 - 4e-120 402.0 1.1 4.9e-120 401.8 0.8 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 EFE42997.1 - 3.1e-83 279.8 0.4 4e-83 279.5 0.3 1.1 1 0 0 1 1 1 1 Nup133 N terminal like YqaJ PF09588.5 EFE42997.1 - 0.028 14.3 0.0 0.082 12.8 0.0 1.7 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain DUF2781 PF10914.3 EFE42998.1 - 1.3e-21 76.8 6.1 2e-21 76.3 4.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DUF619 PF04768.8 EFE42999.1 - 4.1e-52 176.0 0.0 9.6e-52 174.8 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Pyr_redox PF00070.22 EFE43000.1 - 2.1e-17 63.2 0.0 9.5e-13 48.3 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE43000.1 - 1.6e-13 50.9 0.1 5.9e-12 45.8 0.0 4.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE43000.1 - 8.6e-09 35.7 0.0 1.8e-05 24.9 0.0 3.0 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE43000.1 - 8.9e-07 28.1 0.0 0.00053 19.0 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFE43000.1 - 2.2e-06 27.6 0.0 0.0015 18.5 0.0 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFE43000.1 - 3.7e-05 22.7 0.0 0.11 11.3 0.0 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFE43000.1 - 5.1e-05 23.1 0.7 0.13 12.0 0.0 3.8 3 1 1 4 4 4 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 EFE43000.1 - 6.9e-05 21.9 0.0 0.21 10.4 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Trp_halogenase PF04820.9 EFE43000.1 - 0.00025 19.7 0.0 4.1 5.9 0.0 3.1 2 1 0 3 3 3 3 Tryptophan halogenase HI0933_like PF03486.9 EFE43000.1 - 0.00049 18.6 0.0 0.18 10.2 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein TrkA_N PF02254.13 EFE43000.1 - 0.00061 19.7 0.0 0.49 10.4 0.0 2.4 2 0 0 2 2 2 2 TrkA-N domain FAD_binding_3 PF01494.14 EFE43000.1 - 0.0046 16.0 0.0 0.21 10.5 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.1 EFE43000.1 - 0.0066 16.6 0.0 0.7 10.1 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding DUF1188 PF06690.6 EFE43000.1 - 0.065 12.3 0.0 0.19 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) p450 PF00067.17 EFE43001.1 - 6.2e-61 206.3 0.0 8.2e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RRN9 PF10680.4 EFE43001.1 - 0.044 13.5 0.0 0.84 9.4 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor TPR_12 PF13424.1 EFE43002.1 - 4.8e-36 122.5 13.5 1.7e-11 43.8 0.2 5.9 3 1 2 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.1 EFE43002.1 - 5.8e-29 99.1 11.8 5.2e-05 23.0 0.1 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.1 EFE43002.1 - 2.5e-09 36.6 1.1 0.021 14.4 0.1 4.8 5 0 0 5 5 5 2 TPR repeat TPR_2 PF07719.12 EFE43002.1 - 8e-09 34.7 6.3 0.41 10.6 0.0 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFE43002.1 - 2.8e-07 31.0 10.9 0.025 15.2 1.7 5.5 4 1 2 6 6 6 3 Tetratricopeptide repeat Apc3 PF12895.2 EFE43002.1 - 5.7e-07 29.5 0.1 0.28 11.3 0.0 3.8 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 EFE43002.1 - 3.1e-06 27.4 8.2 0.31 11.4 0.0 6.1 4 2 1 5 5 5 1 Tetratricopeptide repeat NB-ARC PF00931.17 EFE43002.1 - 4.7e-06 25.6 0.0 1.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TPR_4 PF07721.9 EFE43002.1 - 5e-05 23.3 14.8 0.16 12.5 0.4 6.1 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE43002.1 - 6.8e-05 22.3 7.2 3.7 7.5 0.0 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFE43002.1 - 0.00028 20.3 6.2 0.14 11.7 0.1 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat AAA_22 PF13401.1 EFE43002.1 - 0.00029 20.9 0.0 0.0021 18.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain TPR_8 PF13181.1 EFE43002.1 - 0.00043 19.8 2.5 4.2 7.3 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFE43002.1 - 0.00067 20.0 14.4 1.5 9.6 0.0 7.2 5 2 3 8 8 7 2 Tetratricopeptide repeat AAA_17 PF13207.1 EFE43002.1 - 0.0089 16.8 0.1 0.69 10.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain DUF3427 PF11907.3 EFE43002.1 - 0.012 14.5 0.7 0.091 11.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3427) NACHT PF05729.7 EFE43002.1 - 0.021 14.4 0.0 0.058 13.0 0.0 1.8 1 0 0 1 1 1 0 NACHT domain DUF1664 PF07889.7 EFE43002.1 - 0.037 13.8 7.5 0.12 12.2 0.2 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF4477 PF14780.1 EFE43002.1 - 0.039 13.3 0.1 0.12 11.7 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) Arf PF00025.16 EFE43002.1 - 0.042 13.0 0.0 0.14 11.3 0.0 1.7 1 1 0 1 1 1 0 ADP-ribosylation factor family TPR_17 PF13431.1 EFE43002.1 - 0.16 12.2 4.2 1.6 9.1 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat FlaC_arch PF05377.6 EFE43002.1 - 4.1 7.3 6.5 20 5.1 0.0 3.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Arv1 PF04161.8 EFE43003.1 - 7.1e-28 97.9 7.9 7.4e-17 61.9 1.0 3.2 2 1 1 3 3 3 3 Arv1-like family Dabb PF07876.7 EFE43004.1 - 1.4e-15 57.5 0.0 1.5e-15 57.3 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Aminotran_3 PF00202.16 EFE43006.1 - 4e-90 302.0 0.0 4.8e-90 301.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III BAR_2 PF10455.4 EFE43007.1 - 1.2e-61 208.1 0.4 1.9e-61 207.5 0.3 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 EFE43007.1 - 1.4e-19 70.4 3.7 1.9e-18 66.8 2.6 2.0 1 1 0 1 1 1 1 BAR domain GAS PF13851.1 EFE43007.1 - 0.035 13.3 2.1 2.3 7.3 0.6 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding ATP-synt_B PF00430.13 EFE43007.1 - 0.22 11.3 4.1 0.47 10.2 0.5 2.5 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) CENP-B_dimeris PF09026.5 EFE43009.1 - 0.014 15.6 2.1 0.025 14.8 1.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PI3K_1B_p101 PF10486.4 EFE43009.1 - 0.03 11.9 4.0 0.038 11.5 2.8 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Radial_spoke PF04712.7 EFE43009.1 - 0.18 10.5 5.9 0.41 9.3 1.7 2.0 2 0 0 2 2 2 0 Radial spokehead-like protein GAGA_bind PF06217.7 EFE43009.1 - 0.73 9.7 8.4 0.91 9.4 5.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family FAM176 PF14851.1 EFE43009.1 - 1.5 8.4 6.6 3.8 7.1 0.8 2.2 2 0 0 2 2 2 0 FAM176 family DUF572 PF04502.8 EFE43009.1 - 2.7 7.1 14.9 3.6 6.7 10.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) DDRGK PF09756.4 EFE43009.1 - 3.7 6.9 17.2 3 7.2 1.7 2.1 2 0 0 2 2 2 0 DDRGK domain Glyco_hydro_72 PF03198.9 EFE43010.1 - 1.6e-118 395.2 1.5 2e-118 394.9 1.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 EFE43010.1 - 2.9e-23 82.1 0.2 6.3e-23 81.0 0.1 1.6 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.12 EFE43010.1 - 6.2e-05 22.0 0.1 0.0002 20.3 0.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.13 EFE43010.1 - 0.042 13.0 0.6 6.3 5.9 0.1 2.4 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) Baculo_gp64 PF03273.8 EFE43010.1 - 0.17 9.9 0.1 0.27 9.3 0.0 1.2 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family Sulfatase PF00884.18 EFE43012.1 - 3e-21 75.9 0.3 6.3e-21 74.8 0.2 1.5 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 EFE43012.1 - 4.7e-07 29.4 0.0 1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.12 EFE43012.1 - 0.0071 14.8 0.0 0.011 14.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) JmjC PF02373.17 EFE43013.1 - 6e-06 26.4 0.0 1.4e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase ZZ PF00569.12 EFE43013.1 - 4.9e-05 22.7 8.1 4.9e-05 22.7 5.6 2.7 2 1 0 2 2 2 1 Zinc finger, ZZ type zf-4CXXC_R1 PF10497.4 EFE43013.1 - 0.0015 18.6 10.6 0.0015 18.6 7.3 2.2 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Baculo_IE-1 PF05290.6 EFE43013.1 - 0.043 13.5 8.0 0.022 14.5 0.9 2.3 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Cupin_2 PF07883.6 EFE43013.1 - 0.12 11.8 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Polyketide_cyc PF03364.15 EFE43015.1 - 2.5e-19 69.5 0.0 4.9e-19 68.6 0.0 1.5 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sod_Fe_C PF02777.13 EFE43016.1 - 7e-17 61.1 0.0 2.3e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain PIG-S PF10510.4 EFE43017.1 - 1.4e-174 581.6 3.9 1.6e-174 581.3 2.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein PQQ_2 PF13360.1 EFE43018.1 - 1.1e-06 28.3 0.3 0.0021 17.5 0.0 2.2 1 1 1 2 2 2 2 PQQ-like domain WD40 PF00400.27 EFE43018.1 - 0.005 16.6 5.5 0.6 10.0 0.2 4.6 4 1 0 4 4 4 1 WD domain, G-beta repeat TLP-20 PF06088.6 EFE43018.1 - 0.0068 16.0 1.8 0.011 15.4 1.2 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Nucleoplasmin PF03066.10 EFE43018.1 - 0.0099 15.3 2.5 0.016 14.6 1.7 1.5 1 0 0 1 1 1 1 Nucleoplasmin CDC45 PF02724.9 EFE43018.1 - 0.37 8.7 7.3 0.5 8.3 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 EFE43018.1 - 1 7.7 7.9 1.5 7.2 5.5 1.1 1 0 0 1 1 1 0 Daxx Family Tom37_C PF11801.3 EFE43018.1 - 1.1 9.1 3.5 1.7 8.4 2.4 1.2 1 0 0 1 1 1 0 Tom37 C-terminal domain Med19 PF10278.4 EFE43018.1 - 2.8 7.6 8.6 84 2.7 6.3 2.1 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Fe-ADH PF00465.14 EFE43019.1 - 5.6e-76 255.5 1.5 6.3e-76 255.3 1.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 EFE43019.1 - 7.8e-16 58.1 0.1 1.1e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Diphthamide_syn PF01866.12 EFE43020.1 - 6.4e-52 176.6 0.1 2.1e-51 174.9 0.0 1.8 2 1 0 2 2 2 1 Putative diphthamide synthesis protein Methyltransf_12 PF08242.7 EFE43023.1 - 4.4e-15 55.9 0.0 2e-14 53.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE43023.1 - 1.8e-11 44.3 0.0 4e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE43023.1 - 4.2e-10 39.5 0.0 7.3e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE43023.1 - 4.7e-09 36.8 0.0 1.3e-08 35.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE43023.1 - 7.7e-09 35.3 0.0 1.2e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE43023.1 - 2.2e-07 31.1 0.0 4.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE43023.1 - 4.8e-07 29.8 0.1 1.7e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE43023.1 - 3.8e-05 22.9 0.0 6.3e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.12 EFE43023.1 - 8.3e-05 21.6 0.0 0.012 14.5 0.0 2.1 1 1 1 2 2 2 2 NNMT/PNMT/TEMT family MTS PF05175.9 EFE43023.1 - 0.00083 18.7 0.1 0.0014 18.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.9 EFE43023.1 - 0.0019 17.3 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.4 EFE43023.1 - 0.0028 17.1 0.0 0.0042 16.5 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_24 PF13578.1 EFE43023.1 - 0.0044 17.8 0.0 0.011 16.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DUF3419 PF11899.3 EFE43023.1 - 0.018 13.8 0.0 0.025 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) Methyltransf_8 PF05148.10 EFE43023.1 - 0.045 13.3 0.0 0.091 12.3 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase FmrO PF07091.6 EFE43023.1 - 0.047 12.6 0.0 0.071 12.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) CMAS PF02353.15 EFE43023.1 - 0.05 12.6 0.0 0.086 11.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Sugar_tr PF00083.19 EFE43024.1 - 7.7e-92 308.2 28.3 8.3e-48 163.0 2.0 3.3 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE43024.1 - 3.4e-14 52.3 40.3 4.1e-08 32.3 16.9 2.8 2 1 0 3 3 3 2 Major Facilitator Superfamily HlyIII PF03006.15 EFE43025.1 - 5e-58 196.1 23.4 6.3e-58 195.8 16.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related GlnD_UR_UTase PF08335.6 EFE43025.1 - 0.55 10.0 5.3 0.72 9.6 0.4 2.2 1 1 1 2 2 2 0 GlnD PII-uridylyltransferase FimP PF09766.4 EFE43026.1 - 1.2e-24 87.0 10.9 1.6e-24 86.6 7.6 1.1 1 0 0 1 1 1 1 Fms-interacting protein DUF4200 PF13863.1 EFE43026.1 - 0.00013 21.8 15.1 0.0029 17.5 0.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4200) K-box PF01486.12 EFE43026.1 - 0.023 14.4 0.8 0.023 14.4 0.5 3.2 2 2 1 3 3 3 0 K-box region DUF948 PF06103.6 EFE43026.1 - 0.065 13.1 3.2 4.1 7.3 0.0 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Pinin_SDK_memA PF04696.8 EFE43026.1 - 1.8 8.1 9.5 0.43 10.1 2.4 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region IncA PF04156.9 EFE43026.1 - 2.2 7.8 15.7 0.92 9.0 1.8 2.2 2 0 0 2 2 2 0 IncA protein DUF972 PF06156.8 EFE43026.1 - 2.6 8.4 11.1 2.2 8.6 1.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF972) BBS2_C PF14782.1 EFE43026.1 - 4.1 5.8 10.6 6.1 5.2 0.2 2.1 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal DUF349 PF03993.7 EFE43026.1 - 8.4 6.6 11.7 0.41 10.8 3.9 2.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) DIE2_ALG10 PF04922.7 EFE43027.1 - 3.2e-33 115.3 2.8 1e-32 113.6 1.9 1.7 1 1 0 1 1 1 1 DIE2/ALG10 family Sld5 PF05916.6 EFE43028.1 - 6.7e-27 93.9 0.0 1.1e-26 93.1 0.0 1.4 1 1 0 1 1 1 1 GINS complex protein CUE PF02845.11 EFE43029.1 - 1.8e-10 40.1 0.0 2.7e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 CUE domain FDF PF09532.5 EFE43029.1 - 0.52 10.8 2.9 0.27 11.8 0.5 1.7 2 1 0 2 2 2 0 FDF domain SMC_N PF02463.14 EFE43030.1 - 2.1e-46 157.8 0.0 9e-46 155.8 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EFE43030.1 - 5.4e-22 78.0 1.4 6.7e-21 74.4 0.2 2.9 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 EFE43030.1 - 1.1e-05 25.5 6.4 1.4e-05 25.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain MscS_porin PF12795.2 EFE43030.1 - 0.00013 21.4 18.2 0.00013 21.4 12.6 5.7 3 2 3 6 6 6 1 Mechanosensitive ion channel porin domain GAS PF13851.1 EFE43030.1 - 0.00095 18.4 7.9 0.00095 18.4 5.5 7.2 2 2 3 7 7 7 3 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 EFE43030.1 - 0.11 11.7 32.2 0.44 9.6 1.1 5.8 3 2 6 9 9 9 0 Reovirus sigma C capsid protein GDI PF00996.13 EFE43031.1 - 3.5e-153 510.0 0.0 4.4e-153 509.6 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NOT2_3_5 PF04153.13 EFE43033.1 - 3.3e-33 114.4 0.1 3.3e-33 114.4 0.1 2.6 2 1 0 2 2 2 1 NOT2 / NOT3 / NOT5 family CDC73 PF05179.9 EFE43034.1 - 5.2e-38 130.9 0.5 5.2e-38 130.9 0.4 3.7 3 1 0 3 3 3 1 RNA pol II accessory factor, Cdc73 family X PF00739.14 EFE43034.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.3 3 0 0 3 3 3 0 Trans-activation protein X DUF3413 PF11893.3 EFE43034.1 - 4 6.2 4.6 6.9 5.4 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) RGS PF00615.14 EFE43035.1 - 2.2e-30 105.2 0.0 7.5e-30 103.4 0.0 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.16 EFE43035.1 - 7.7e-26 89.6 0.2 5.8e-19 67.6 0.0 3.2 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) BAF1_ABF1 PF04684.8 EFE43035.1 - 1.2 7.9 31.2 0.04 12.7 14.0 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Peptidase_S64 PF08192.6 EFE43035.1 - 1.9 6.6 16.3 2.8 6.1 11.3 1.3 1 0 0 1 1 1 0 Peptidase family S64 RAP1 PF07218.6 EFE43035.1 - 6 4.8 11.7 10 4.0 8.1 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Draxin PF15550.1 EFE43036.1 - 0.0047 16.6 0.6 0.005 16.5 0.4 1.0 1 0 0 1 1 1 1 Draxin Nop25 PF09805.4 EFE43036.1 - 0.01 15.8 12.4 0.012 15.6 8.6 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Tankyrase_bdg_C PF15327.1 EFE43036.1 - 0.12 12.5 5.2 0.15 12.1 3.6 1.2 1 0 0 1 1 1 0 Tankyrase binding protein C terminal domain DUF755 PF05501.6 EFE43036.1 - 0.15 12.0 4.2 0.21 11.6 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF4139 PF13598.1 EFE43036.1 - 0.18 11.0 2.1 0.2 10.8 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) TIM21 PF08294.6 EFE43036.1 - 0.34 10.5 2.6 0.37 10.4 1.8 1.1 1 0 0 1 1 1 0 TIM21 DUF4483 PF14825.1 EFE43036.1 - 0.93 9.1 7.3 1.1 8.8 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4483) Circo_capsid PF02443.10 EFE43036.1 - 1.1 8.6 9.0 1.1 8.5 6.2 1.1 1 0 0 1 1 1 0 Circovirus capsid protein CDC27 PF09507.5 EFE43036.1 - 2.1 7.4 10.5 2.7 7.1 7.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 NPR3 PF03666.8 EFE43036.1 - 2.9 6.3 4.9 3.4 6.0 3.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1675 PF07897.6 EFE43036.1 - 3.8 7.3 7.7 4.6 7.0 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Cas_Csy4 PF09618.5 EFE43036.1 - 3.9 7.2 5.5 4.8 6.9 3.8 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) Adeno_terminal PF02459.10 EFE43038.1 - 3.8 5.5 12.0 3.8 5.5 8.3 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein TMEM154 PF15102.1 EFE43038.1 - 4.4 7.0 6.7 4.6 6.9 4.6 1.1 1 0 0 1 1 1 0 TMEM154 protein family PBP1_TM PF14812.1 EFE43038.1 - 4.5 7.6 9.7 4.9 7.5 6.7 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pap_E4 PF02711.9 EFE43038.1 - 8.6 7.2 6.2 8.2 7.3 4.3 1.0 1 0 0 1 1 1 0 E4 protein Ofd1_CTDD PF10637.4 EFE43040.1 - 1.4e-96 322.7 0.1 2.2e-91 305.6 0.4 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 EFE43040.1 - 2e-15 57.1 0.0 4e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 EFE43040.1 - 0.0068 16.0 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily APH PF01636.18 EFE43041.1 - 2.4e-09 37.3 0.0 6.2e-09 35.9 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family COesterase PF00135.23 EFE43043.1 - 2.1e-94 317.1 0.0 3.1e-94 316.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE43043.1 - 1.2e-06 28.2 0.0 9.8e-06 25.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFE43043.1 - 0.09 11.9 0.2 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family p450 PF00067.17 EFE43044.1 - 5e-67 226.4 0.0 6.4e-67 226.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sdh_cyt PF01127.17 EFE43044.1 - 0.13 12.1 0.2 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit FAD_binding_4 PF01565.18 EFE43045.1 - 3.4e-32 110.8 8.1 1.6e-31 108.6 5.4 2.0 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 EFE43045.1 - 0.04 13.8 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like FAD_binding_4 PF01565.18 EFE43046.1 - 1.6e-20 73.0 1.0 2.6e-20 72.3 0.7 1.3 1 0 0 1 1 1 1 FAD binding domain DRMBL PF07522.9 EFE43047.1 - 9.4e-33 112.5 0.0 1.9e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 EFE43047.1 - 1.3e-10 41.1 0.1 2.4e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EFE43047.1 - 0.1 12.2 1.6 0.26 10.9 1.1 1.7 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Methyltransf_11 PF08241.7 EFE43048.1 - 1.2e-06 28.8 0.0 2.8e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE43048.1 - 0.0089 15.7 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain zf-BED PF02892.10 EFE43049.1 - 0.0052 16.5 4.7 0.41 10.4 0.6 2.5 2 0 0 2 2 2 2 BED zinc finger SH3BGR PF04908.10 EFE43050.1 - 0.00017 21.4 0.7 0.0027 17.6 0.0 2.8 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.19 EFE43050.1 - 0.17 11.8 0.2 0.52 10.3 0.0 1.9 2 0 0 2 2 2 0 Glutaredoxin Pkinase PF00069.20 EFE43051.1 - 2.1e-24 86.1 0.0 8.9e-24 84.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43051.1 - 1.1e-07 31.2 0.0 1.5e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE43051.1 - 0.017 14.8 0.2 0.036 13.7 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 EFE43051.1 - 0.079 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ribul_P_3_epim PF00834.14 EFE43052.1 - 5.3e-57 192.1 0.1 6.2e-55 185.4 0.0 2.9 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.19 EFE43052.1 - 0.086 12.2 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family ThiG PF05690.9 EFE43052.1 - 0.098 11.7 0.3 0.14 11.1 0.2 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG zf-C2H2_4 PF13894.1 EFE43053.1 - 0.046 14.0 0.4 0.046 14.0 0.3 4.0 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE43053.1 - 2.8 8.4 14.3 5.5 7.5 0.2 4.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type ABC2_membrane PF01061.19 EFE43054.1 - 4.3e-90 300.4 60.8 2.8e-48 163.8 13.4 3.1 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 EFE43054.1 - 3.9e-39 132.4 4.2 3e-35 119.9 0.0 3.1 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.22 EFE43054.1 - 1.7e-36 125.5 0.0 6.4e-17 62.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.1 EFE43054.1 - 5.2e-24 84.1 0.1 1.1e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal ABC2_membrane_3 PF12698.2 EFE43054.1 - 4.6e-09 35.7 50.5 0.00011 21.4 14.0 3.2 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_25 PF13481.1 EFE43054.1 - 1.8e-06 27.4 0.0 0.00018 20.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFE43054.1 - 6e-06 25.5 0.1 0.0016 17.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_33 PF13671.1 EFE43054.1 - 1e-05 25.4 0.0 0.00039 20.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFE43054.1 - 0.00017 21.9 0.1 0.046 14.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 EFE43054.1 - 0.00028 20.3 0.7 0.012 15.0 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 EFE43054.1 - 0.0003 20.2 0.7 0.035 13.6 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE43054.1 - 0.0023 17.9 1.7 0.2 11.6 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 EFE43054.1 - 0.0033 17.5 0.1 0.9 9.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFE43054.1 - 0.0042 17.8 0.0 0.36 11.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 EFE43054.1 - 0.035 13.3 0.0 2.6 7.2 0.0 3.0 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.1 EFE43054.1 - 0.035 14.0 0.1 0.71 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 EFE43054.1 - 0.063 13.0 1.0 3 7.6 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain NACHT PF05729.7 EFE43054.1 - 0.067 12.8 2.1 2.1 7.9 0.1 2.8 3 0 0 3 3 3 0 NACHT domain MMR_HSR1 PF01926.18 EFE43054.1 - 0.077 12.9 0.1 9.8 6.1 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_21 PF13304.1 EFE43054.1 - 0.077 12.9 0.0 1.3 8.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EFE43054.1 - 0.094 12.2 0.0 3.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.1 EFE43054.1 - 0.15 11.6 0.1 5.2 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain MS_channel PF00924.13 EFE43055.1 - 3.1e-24 85.4 2.7 6.8e-24 84.3 1.9 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.27 EFE43055.1 - 3.9e-05 22.6 0.4 8.9e-05 21.5 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 EFE43055.1 - 0.00012 21.2 0.2 0.00031 19.9 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 EFE43055.1 - 0.00041 20.4 0.6 0.001 19.1 0.4 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 EFE43055.1 - 0.0005 19.7 0.1 0.0014 18.3 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain DUF2648 PF10855.3 EFE43055.1 - 0.038 13.4 0.0 0.093 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2648) DUF1980 PF09323.5 EFE43056.1 - 0.77 9.4 2.6 0.87 9.2 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Tubulin PF00091.20 EFE43057.1 - 1.3e-58 198.3 0.0 1e-57 195.4 0.0 2.0 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EFE43057.1 - 5.8e-43 145.9 0.0 9.9e-43 145.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 EFE43057.1 - 0.00054 19.4 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain TauD PF02668.11 EFE43058.1 - 1.5e-59 201.8 0.0 2e-59 201.3 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 EFE43058.1 - 0.065 12.1 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 CsiD Glutaredoxin PF00462.19 EFE43059.1 - 2.3e-18 65.9 0.0 8.9e-17 60.8 0.0 2.5 2 1 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.15 EFE43059.1 - 1.1e-12 47.5 0.0 2.7e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EFE43059.1 - 0.0014 18.6 0.0 0.039 14.0 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like ArsC PF03960.10 EFE43059.1 - 0.057 13.4 0.0 2.1 8.4 0.0 2.2 2 0 0 2 2 2 0 ArsC family OPT PF03169.10 EFE43060.1 - 1.5e-171 572.0 51.7 1.8e-171 571.7 35.8 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.1 EFE43060.1 - 0.11 11.5 1.1 0.33 10.0 0.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) RNase_T PF00929.19 EFE43061.1 - 7.7e-23 81.5 0.0 1.7e-22 80.4 0.0 1.6 2 0 0 2 2 2 1 Exonuclease Menin PF05053.8 EFE43062.1 - 0.33 9.0 4.8 0.5 8.4 3.3 1.3 1 0 0 1 1 1 0 Menin Beta_elim_lyase PF01212.16 EFE43063.1 - 4.9e-64 216.2 0.0 6.4e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EFE43063.1 - 0.1 11.6 0.1 1.2 8.0 0.0 2.0 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 EFE43063.1 - 0.13 10.5 0.0 0.19 9.9 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme CN_hydrolase PF00795.17 EFE43064.1 - 2.1e-31 108.7 0.1 2.7e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Pkinase PF00069.20 EFE43065.1 - 3.2e-53 180.5 0.0 1.2e-44 152.4 0.0 2.4 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43065.1 - 3.8e-19 68.7 0.0 1.2e-15 57.2 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase FHA PF00498.21 EFE43065.1 - 8.3e-09 35.4 0.2 7e-08 32.4 0.2 2.4 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.1 EFE43065.1 - 0.0062 15.5 0.0 0.015 14.2 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Peptidase_M28 PF04389.12 EFE43066.1 - 3.9e-17 62.5 0.0 7e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.10 EFE43066.1 - 1.2e-15 57.1 0.0 2e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.17 EFE43066.1 - 7.2e-07 28.8 0.4 1.5e-05 24.6 0.1 2.6 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.23 EFE43066.1 - 0.021 14.3 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Glyco_transf_34 PF05637.7 EFE43067.1 - 4.4e-63 212.9 0.0 6.6e-63 212.3 0.0 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF566 PF04484.7 EFE43067.1 - 7.8 5.9 11.6 12 5.2 8.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) NDUFB10 PF10249.4 EFE43068.1 - 0.0043 17.1 0.0 0.0046 17.0 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 BRO1 PF03097.13 EFE43069.1 - 2.1e-08 33.3 0.0 4.1e-08 32.3 0.0 1.4 1 1 0 1 1 1 1 BRO1-like domain DicB PF05358.6 EFE43069.1 - 0.047 13.1 0.0 0.36 10.3 0.0 2.4 2 0 0 2 2 2 0 DicB protein TAFII55_N PF04658.8 EFE43070.1 - 1.9e-51 173.7 0.2 9.9e-51 171.4 0.0 2.1 2 0 0 2 2 2 1 TAFII55 protein conserved region Bromo_TP PF07524.8 EFE43071.1 - 3.5e-10 39.4 0.0 6.1e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated LysM PF01476.15 EFE43072.1 - 6.6e-11 41.9 1.0 9.4e-07 28.6 0.0 4.9 5 0 0 5 5 5 2 LysM domain DUF1653 PF07866.6 EFE43073.1 - 0.043 13.9 0.1 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1653) Ank_2 PF12796.2 EFE43074.1 - 1.6e-43 146.9 0.0 3.6e-15 56.0 0.0 4.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EFE43074.1 - 1e-35 119.7 8.4 9e-05 22.0 0.0 9.4 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.1 EFE43074.1 - 9.2e-28 93.5 1.8 0.0082 16.2 0.0 9.4 10 0 0 10 10 10 7 Ankyrin repeat Ank_4 PF13637.1 EFE43074.1 - 7.3e-27 93.2 3.2 0.00013 22.3 0.1 6.1 3 1 4 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE43074.1 - 4.1e-24 84.0 5.3 0.0016 18.6 0.0 9.1 3 2 6 9 9 9 7 Ankyrin repeats (many copies) FAD_binding_7 PF03441.9 EFE43076.1 - 2.3e-83 279.6 0.3 1.4e-71 240.9 0.0 2.3 1 1 1 2 2 2 2 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 EFE43076.1 - 2.5e-41 141.1 0.1 4.4e-41 140.3 0.1 1.4 1 0 0 1 1 1 1 DNA photolyase Hormone_1 PF00103.15 EFE43076.1 - 0.043 13.1 0.0 0.11 11.7 0.0 1.6 1 0 0 1 1 1 0 Somatotropin hormone family Aldo_ket_red PF00248.16 EFE43077.1 - 4.3e-55 186.5 0.0 5.6e-55 186.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Peptidase_M14 PF00246.19 EFE43078.1 - 9.4e-19 68.0 0.0 1.5e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.3 EFE43078.1 - 0.00092 18.3 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) AstE_AspA PF04952.9 EFE43078.1 - 0.032 13.1 0.0 0.07 12.0 0.0 1.5 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Peptidase_M36 PF02128.10 EFE43079.1 - 2.4e-157 523.6 3.6 2.9e-157 523.3 2.5 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.8 EFE43079.1 - 1.3e-13 50.1 1.8 2.7e-13 49.1 1.3 1.6 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif adh_short PF00106.20 EFE43080.1 - 1.6e-08 34.6 0.0 2.2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE43080.1 - 2.6e-06 27.2 0.0 4.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 KR domain APH PF01636.18 EFE43081.1 - 7.3e-08 32.4 0.0 1.2e-06 28.4 0.0 2.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Hydrolase_3 PF08282.7 EFE43082.1 - 3.6e-10 39.8 0.0 1.6e-08 34.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PMM PF03332.8 EFE43082.1 - 2.4e-09 37.0 0.0 3e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase S6PP PF05116.8 EFE43082.1 - 0.00014 21.2 0.0 0.027 13.7 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase MS_channel PF00924.13 EFE43082.1 - 0.087 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel ISN1 PF06437.6 EFE43082.1 - 0.17 10.5 0.0 0.26 9.9 0.0 1.3 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase F_bP_aldolase PF01116.15 EFE43083.1 - 1.2e-96 323.2 0.0 1.3e-96 323.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II UCH PF00443.24 EFE43085.1 - 4.2e-41 140.8 0.7 3e-34 118.3 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE43085.1 - 1.4e-11 44.3 1.1 1.9e-10 40.6 0.7 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rubredoxin PF00301.15 EFE43085.1 - 0.12 12.2 0.8 2.8 7.8 0.1 2.4 2 0 0 2 2 2 0 Rubredoxin zinc_ribbon_4 PF13717.1 EFE43085.1 - 0.94 9.2 8.2 10 5.9 1.6 3.0 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EFE43085.1 - 0.99 9.0 7.4 9.4 5.9 1.5 2.9 3 0 0 3 3 3 0 zinc-ribbon domain SOBP PF15279.1 EFE43086.1 - 1.8 8.8 17.5 2.3 8.5 12.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein MIP-T3 PF10243.4 EFE43086.1 - 2.7 6.3 50.8 3.1 6.1 35.2 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 ATP-grasp_4 PF13535.1 EFE43089.1 - 8.9e-15 54.8 0.0 2e-14 53.7 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EFE43089.1 - 3e-08 33.7 0.0 5.1e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EFE43089.1 - 0.001 17.9 0.0 0.0081 14.9 0.0 2.2 2 1 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon CPSase_L_D2 PF02786.12 EFE43089.1 - 0.16 11.2 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain PRCC PF10253.4 EFE43090.1 - 3.2e-37 128.9 2.5 3.2e-37 128.9 1.7 3.0 3 1 0 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting HNH_2 PF13391.1 EFE43090.1 - 1.3e-16 60.0 0.1 2.9e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease BRF1 PF07741.8 EFE43091.1 - 0.038 14.2 17.7 0.062 13.5 7.4 3.1 2 1 0 2 2 2 0 Brf1-like TBP-binding domain Glyco_trans_1_2 PF13524.1 EFE43091.1 - 2.4 8.5 5.4 5.3 7.3 3.5 1.8 1 1 0 1 1 1 0 Glycosyl transferases group 1 Lectin_leg-like PF03388.8 EFE43092.1 - 4e-47 160.2 0.0 5.4e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Pkinase PF00069.20 EFE43093.1 - 2.9e-70 236.4 0.0 4.8e-70 235.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43093.1 - 9.1e-37 126.5 0.0 1.3e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE43093.1 - 8.2e-07 28.2 0.0 1.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EFE43093.1 - 0.047 12.5 0.0 0.085 11.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 DUF605 PF04652.11 EFE43093.1 - 0.16 11.3 25.4 0.21 10.9 17.6 1.1 1 0 0 1 1 1 0 Vta1 like YrbL-PhoP_reg PF10707.4 EFE43093.1 - 0.28 10.4 0.0 0.28 10.4 0.0 1.8 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL PAT1 PF09770.4 EFE43093.1 - 2.5 6.2 18.9 3 5.9 13.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SIN1 PF05422.7 EFE43094.1 - 6.9e-31 107.3 0.1 1.6e-17 63.2 0.0 2.2 2 0 0 2 2 2 2 Stress-activated map kinase interacting protein 1 (SIN1) TUG-UBL1 PF11470.3 EFE43094.1 - 0.00077 19.3 0.1 0.0017 18.2 0.1 1.5 1 0 0 1 1 1 1 GLUT4 regulating protein TUG DUF4337 PF14235.1 EFE43095.1 - 0.025 14.4 0.5 0.032 14.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Peptidase_M28 PF04389.12 EFE43096.1 - 1.4e-31 109.6 0.3 3.2e-31 108.4 0.2 1.7 1 0 0 1 1 1 1 Peptidase family M28 Mito_carr PF00153.22 EFE43096.1 - 3.9e-09 36.1 0.7 0.0021 17.6 0.0 2.8 3 0 0 3 3 3 2 Mitochondrial carrier protein Peptidase_M20 PF01546.23 EFE43096.1 - 0.024 14.1 0.3 0.024 14.1 0.2 1.8 2 0 0 2 2 2 0 Peptidase family M20/M25/M40 Histone PF00125.19 EFE43097.1 - 2.5e-15 56.3 0.2 3.1e-15 56.0 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EFE43097.1 - 7.9e-05 22.7 0.1 0.00011 22.2 0.1 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 EFE43097.1 - 0.00011 22.0 0.1 0.00016 21.5 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 EFE43097.1 - 0.0002 21.3 0.1 0.00038 20.4 0.1 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EFE43097.1 - 0.0084 15.8 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated CENP-T PF15511.1 EFE43097.1 - 0.041 13.1 0.0 0.044 13.0 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TFIID_20kDa PF03847.8 EFE43097.1 - 0.053 13.8 0.1 0.097 12.9 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A CBM_21 PF03370.8 EFE43098.1 - 3.7e-32 110.6 0.1 1e-31 109.2 0.0 1.8 2 0 0 2 2 2 1 Putative phosphatase regulatory subunit DUF3464 PF11947.3 EFE43099.1 - 0.0031 16.9 0.0 0.0061 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3464) DUF912 PF06024.7 EFE43099.1 - 0.055 13.5 3.9 0.17 11.9 2.7 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) CDC45 PF02724.9 EFE43099.1 - 0.078 10.9 0.0 0.08 10.9 0.0 1.1 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.11 EFE43099.1 - 0.34 10.3 12.2 0.46 9.9 8.4 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 NST1 PF13945.1 EFE43099.1 - 0.41 10.6 8.9 0.57 10.2 6.1 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator SR-25 PF10500.4 EFE43099.1 - 1.5 8.2 14.5 2 7.8 10.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NARP1 PF12569.3 EFE43099.1 - 4.6 5.8 12.0 6.2 5.4 8.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TT_ORF2 PF02957.10 EFE43099.1 - 6.4 7.5 7.8 15 6.2 5.4 1.6 1 0 0 1 1 1 0 TT viral ORF2 APH PF01636.18 EFE43102.1 - 3.6e-14 53.0 0.1 7.2e-14 52.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE43102.1 - 0.00034 20.2 0.0 0.0005 19.6 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 EFE43102.1 - 0.0088 14.7 0.0 0.013 14.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.15 EFE43102.1 - 0.09 11.9 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase HMGL-like PF00682.14 EFE43103.1 - 1.2e-65 221.5 0.0 1.8e-65 220.9 0.0 1.3 1 0 0 1 1 1 1 HMGL-like PTH2 PF01981.11 EFE43105.1 - 0.021 14.4 0.1 0.035 13.7 0.1 1.3 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 Ribosomal_60s PF00428.14 EFE43105.1 - 0.031 14.6 0.2 0.036 14.4 0.1 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein CENP-B_dimeris PF09026.5 EFE43105.1 - 0.043 14.0 3.0 0.055 13.7 2.0 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sec23_trunk PF04811.10 EFE43105.1 - 0.062 12.6 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain Myc_N PF01056.13 EFE43105.1 - 0.096 11.8 0.5 0.1 11.7 0.3 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Nucleoplasmin PF03066.10 EFE43105.1 - 0.16 11.4 4.1 0.2 11.1 2.8 1.2 1 0 0 1 1 1 0 Nucleoplasmin Spt5_N PF11942.3 EFE43105.1 - 0.82 10.3 9.8 1.1 9.8 6.8 1.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal SART-1 PF03343.8 EFE43106.1 - 2.3e-167 558.0 51.5 2.6e-167 557.8 35.7 1.0 1 0 0 1 1 1 1 SART-1 family WD40 PF00400.27 EFE43107.1 - 2.5e-21 74.6 2.0 3.2e-06 26.8 0.0 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EFE43107.1 - 0.047 12.4 0.0 3 6.4 0.0 2.4 2 0 0 2 2 2 0 Nup133 N terminal like SR-25 PF10500.4 EFE43108.1 - 0.003 17.0 9.5 0.003 17.0 6.6 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Herpes_DNAp_acc PF04929.7 EFE43108.1 - 6.7 5.5 13.5 6.2 5.6 0.3 2.1 2 0 0 2 2 2 0 Herpes DNA replication accessory factor Occludin_ELL PF07303.8 EFE43109.1 - 0.14 12.8 4.2 0.06 14.0 0.8 2.0 2 0 0 2 2 2 0 Occludin homology domain APH PF01636.18 EFE43111.1 - 5.7e-11 42.6 1.9 7.8e-10 38.8 1.3 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF155 PF02582.9 EFE43112.1 - 8.9e-58 195.0 0.0 1.8e-57 194.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Zip PF02535.17 EFE43112.1 - 4.2 6.2 11.3 0.45 9.4 3.5 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Aldedh PF00171.17 EFE43113.1 - 1e-143 479.0 0.1 1.2e-143 478.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 EFE43113.1 - 0.11 11.7 0.3 0.23 10.6 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Pkinase PF00069.20 EFE43114.1 - 2.5e-27 95.6 0.0 3.3e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43114.1 - 3.2e-13 49.3 0.0 4.4e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 EFE43115.1 - 3.3e-37 126.0 52.6 6.3e-07 29.8 1.4 13.3 13 1 1 14 14 14 8 Sel1 repeat TPR_14 PF13428.1 EFE43115.1 - 0.001 19.5 3.7 14 6.6 0.0 5.9 5 0 0 5 5 5 2 Tetratricopeptide repeat DUF1049 PF06305.6 EFE43115.1 - 0.14 11.6 0.4 0.3 10.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Nucleo_P87 PF07267.6 EFE43116.1 - 0.17 10.5 8.8 0.026 13.2 3.7 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Glypican PF01153.14 EFE43116.1 - 0.28 9.7 4.2 0.39 9.2 2.9 1.2 1 0 0 1 1 1 0 Glypican DUF4140 PF13600.1 EFE43116.1 - 3 8.3 5.8 0.65 10.4 0.3 2.3 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Dus PF01207.12 EFE43118.1 - 6.1e-41 140.2 0.0 1e-28 100.0 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 EFE43118.1 - 8.9e-05 22.0 2.7 0.065 12.9 0.3 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Kelch_5 PF13854.1 EFE43119.1 - 7.9e-16 57.6 0.0 1.9e-06 27.6 0.0 3.8 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 EFE43119.1 - 1.3e-15 56.8 0.3 8.6e-05 22.5 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 EFE43119.1 - 5e-15 54.7 3.3 5.3e-05 22.6 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 EFE43119.1 - 5.1e-15 54.5 0.2 3.4e-07 29.7 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 EFE43119.1 - 1.7e-13 50.0 2.7 1.4e-05 24.7 0.0 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.1 EFE43119.1 - 2.5e-11 43.3 5.5 1.1e-08 34.9 0.0 4.7 5 0 0 5 5 5 1 Galactose oxidase, central domain BTB PF00651.26 EFE43119.1 - 5.1e-08 32.8 0.0 1e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain APH PF01636.18 EFE43120.1 - 1.1e-12 48.2 0.0 1.6e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE43120.1 - 7.4e-08 32.2 0.5 1.4e-07 31.2 0.4 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.15 EFE43120.1 - 0.0011 18.2 0.0 0.0015 17.7 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Pkinase PF00069.20 EFE43120.1 - 0.0043 16.2 0.0 0.88 8.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain DUF1679 PF07914.6 EFE43120.1 - 0.008 14.8 0.0 0.01 14.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) WD40 PF00400.27 EFE43121.1 - 3e-22 77.5 16.8 2.2e-06 27.3 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 EFE43121.1 - 0.00021 21.0 0.4 0.011 15.4 0.1 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A TFIIA PF03153.8 EFE43123.1 - 1.8e-54 186.0 41.4 3.6e-52 178.5 25.4 2.5 2 1 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit zf-H2C2_2 PF13465.1 EFE43125.1 - 0.002 18.3 11.0 0.011 15.9 0.2 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFE43125.1 - 0.0081 16.4 20.3 0.028 14.7 0.4 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger Macoilin PF09726.4 EFE43125.1 - 0.025 12.8 6.7 0.05 11.8 4.7 1.4 1 0 0 1 1 1 0 Transmembrane protein zf-C2H2 PF00096.21 EFE43125.1 - 0.044 14.1 0.8 0.044 14.1 0.6 4.4 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 EFE43125.1 - 0.14 12.3 0.1 0.14 12.3 0.0 3.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding DUF4661 PF15576.1 EFE43126.1 - 0.32 10.6 5.9 0.36 10.4 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) GRP PF07172.6 EFE43126.1 - 8.2 6.9 13.8 1.8 9.1 5.9 2.1 1 1 1 2 2 2 0 Glycine rich protein family Bap31 PF05529.7 EFE43127.1 - 3.3e-61 206.1 0.3 4.9e-61 205.5 0.2 1.2 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like TMF_DNA_bd PF12329.3 EFE43127.1 - 0.0028 17.4 0.8 0.0058 16.3 0.6 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.3 EFE43127.1 - 0.0089 15.7 0.2 0.016 14.9 0.1 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Phage_GP20 PF06810.6 EFE43127.1 - 0.015 14.7 3.7 0.023 14.1 2.6 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF1385 PF07136.6 EFE43127.1 - 0.018 14.1 0.1 0.032 13.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) Spc7 PF08317.6 EFE43127.1 - 0.056 12.0 1.1 0.079 11.6 0.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.10 EFE43127.1 - 0.092 12.2 2.3 0.12 11.8 0.3 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF4349 PF14257.1 EFE43127.1 - 0.12 11.6 0.0 0.36 10.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) DUF2404 PF10296.4 EFE43128.1 - 0.00032 20.7 0.0 0.013 15.6 0.0 2.2 2 0 0 2 2 2 2 Putative integral membrane protein conserved region (DUF2404) Pkinase PF00069.20 EFE43130.1 - 5.7e-63 212.4 0.0 1e-62 211.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43130.1 - 9.8e-35 119.8 0.0 9.1e-30 103.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFE43130.1 - 5.9e-05 22.1 0.0 0.038 12.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.17 EFE43130.1 - 0.0014 17.9 0.0 0.0029 16.9 0.0 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 EFE43130.1 - 0.0021 17.8 0.3 0.0088 15.7 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE43130.1 - 0.066 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TSA PF03249.8 EFE43130.1 - 0.84 8.1 4.8 0.28 9.6 1.1 1.7 2 0 0 2 2 2 0 Type specific antigen Senescence PF06911.7 EFE43131.1 - 6.1e-47 159.6 1.2 9e-47 159.0 0.9 1.3 1 0 0 1 1 1 1 Senescence-associated protein Acyl-CoA_dh_1 PF00441.19 EFE43132.1 - 1e-36 126.3 4.6 7.9e-32 110.4 1.4 2.3 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EFE43132.1 - 2.1e-29 102.3 1.1 6.3e-29 100.8 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 EFE43132.1 - 2e-17 62.4 0.0 3.9e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFE43132.1 - 2.3e-11 44.0 0.5 2.3e-11 44.0 0.3 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 EFE43132.1 - 0.088 12.1 0.1 0.38 10.0 0.0 1.9 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal AgrD PF05931.6 EFE43132.1 - 0.11 12.1 0.0 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 Staphylococcal AgrD protein MFS_1 PF07690.11 EFE43133.1 - 5.5e-25 87.8 35.1 2.8e-18 65.7 7.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.20 EFE43134.1 - 1.3e-35 122.8 0.0 1.9e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43134.1 - 3.4e-14 52.5 0.0 5.6e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE43134.1 - 0.02 14.6 0.0 0.49 10.0 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family ETRAMP PF09716.5 EFE43135.1 - 0.0092 15.9 1.4 0.044 13.7 0.9 2.0 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) YMF19 PF02326.10 EFE43135.1 - 0.029 14.9 2.3 0.029 14.9 1.6 1.6 2 0 0 2 2 2 0 Plant ATP synthase F0 Peptidase_A21 PF03566.8 EFE43135.1 - 0.37 8.8 3.9 0.42 8.6 2.7 1.1 1 0 0 1 1 1 0 Peptidase family A21 DUF3446 PF11928.3 EFE43135.1 - 0.65 10.2 8.0 0.99 9.6 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF2217 PF10265.4 EFE43135.1 - 6.6 5.3 6.7 8.1 5.0 4.7 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Rtt106 PF08512.7 EFE43136.1 - 5.6e-28 96.7 0.0 1.3e-27 95.5 0.0 1.6 2 0 0 2 2 2 1 Histone chaperone Rttp106-like KOW PF00467.24 EFE43137.1 - 3.6e-08 32.8 0.6 7.3e-08 31.8 0.4 1.5 1 0 0 1 1 1 1 KOW motif Ras PF00071.17 EFE43138.1 - 3.7e-38 130.4 0.0 4.3e-21 74.9 0.0 2.2 1 1 1 2 2 2 2 Ras family Miro PF08477.8 EFE43138.1 - 1.2e-05 25.7 0.1 0.0016 18.9 0.0 2.6 2 1 0 2 2 2 1 Miro-like protein Arf PF00025.16 EFE43138.1 - 0.009 15.2 0.0 0.023 13.9 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Podoplanin PF05808.6 EFE43139.1 - 0.0024 17.4 0.0 0.0043 16.6 0.0 1.4 1 0 0 1 1 1 1 Podoplanin MGC-24 PF05283.6 EFE43139.1 - 0.017 14.9 1.5 0.017 14.9 1.0 1.9 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24) Syndecan PF01034.15 EFE43139.1 - 0.074 12.7 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Syndecan domain Rab5ip PF07019.7 EFE43139.1 - 0.094 12.8 0.4 0.18 11.9 0.3 1.4 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) Pex14_N PF04695.8 EFE43139.1 - 0.11 12.6 0.3 0.11 12.6 0.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region VSP PF03302.8 EFE43139.1 - 0.13 10.8 0.4 0.21 10.1 0.3 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein SKG6 PF08693.5 EFE43139.1 - 0.18 11.1 2.3 0.36 10.1 1.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain SOG2 PF10428.4 EFE43139.1 - 0.61 8.6 6.4 0.72 8.4 4.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Aldedh PF00171.17 EFE43140.1 - 1.8e-144 481.5 0.0 2.2e-144 481.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Hydant_A_N PF05378.8 EFE43140.1 - 0.079 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region LuxC PF05893.9 EFE43140.1 - 0.12 11.0 0.2 0.32 9.6 0.1 1.7 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1712 PF08217.6 EFE43141.1 - 1.1e-19 70.1 0.0 2.4e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) adh_short PF00106.20 EFE43143.1 - 9.9e-23 80.8 0.3 1.4e-22 80.4 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE43143.1 - 1.7e-19 70.5 0.1 1.9e-19 70.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE43143.1 - 1.6e-06 27.9 0.2 2.1e-06 27.5 0.2 1.2 1 0 0 1 1 1 1 KR domain EMP24_GP25L PF01105.19 EFE43144.1 - 6.9e-41 139.9 0.0 7.7e-41 139.8 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD PspB PF06667.7 EFE43144.1 - 0.05 13.5 0.7 0.096 12.6 0.5 1.5 1 0 0 1 1 1 0 Phage shock protein B HXXSHH PF07586.6 EFE43144.1 - 0.085 11.7 0.1 0.12 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Peptidase_S46 PF10459.4 EFE43144.1 - 0.12 10.8 1.1 0.41 9.0 0.1 1.8 1 1 1 2 2 2 0 Peptidase S46 TFIID-18kDa PF02269.11 EFE43145.1 - 0.086 12.6 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit RGS PF00615.14 EFE43146.1 - 1.3e-11 44.6 0.0 2.4e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF2638 PF10937.3 EFE43150.1 - 1.4e-40 138.8 0.4 1.6e-40 138.6 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2638) Med18 PF09637.5 EFE43151.1 - 5.6e-44 150.5 0.0 6.4e-44 150.3 0.0 1.0 1 0 0 1 1 1 1 Med18 protein tRNA-synt_2b PF00587.20 EFE43152.1 - 4.9e-67 224.8 0.1 8.7e-67 224.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFE43152.1 - 8.4e-19 67.3 2.4 9.7e-19 67.1 0.0 2.4 3 0 0 3 3 3 1 Anticodon binding domain Brix PF04427.13 EFE43153.1 - 3.3e-37 127.9 0.2 4.8e-37 127.4 0.1 1.2 1 0 0 1 1 1 1 Brix domain Nop14 PF04147.7 EFE43153.1 - 0.6 7.9 25.1 0.79 7.5 17.4 1.1 1 0 0 1 1 1 0 Nop14-like family SRI PF08236.6 EFE43155.1 - 2.3e-21 75.5 13.3 8.1e-21 73.7 9.2 2.0 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.23 EFE43155.1 - 6e-21 75.4 0.3 6e-21 75.4 0.2 3.3 2 2 0 2 2 2 1 SET domain DUF3287 PF11690.3 EFE43155.1 - 0.085 12.9 6.9 0.029 14.4 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) Pox_H7 PF04787.7 EFE43155.1 - 1.6 8.5 8.1 0.83 9.4 4.0 1.6 2 0 0 2 2 2 0 Late protein H7 Es2 PF09751.4 EFE43159.1 - 5.9e-110 368.5 10.8 6.9e-110 368.3 7.5 1.0 1 0 0 1 1 1 1 Nuclear protein Es2 RE_LlaMI PF09562.5 EFE43159.1 - 0.039 13.1 0.1 0.075 12.1 0.1 1.4 1 0 0 1 1 1 0 LlaMI restriction endonuclease Anophelin PF10731.4 EFE43159.1 - 1.1 9.3 6.1 0.32 11.1 1.6 2.1 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito Mid1 PF12929.2 EFE43160.1 - 3.4e-129 431.2 5.9 1.9e-69 234.4 4.0 2.0 1 1 1 2 2 2 2 Stretch-activated Ca2+-permeable channel component Fz PF01392.17 EFE43160.1 - 0.13 12.6 3.0 1.8 8.9 0.5 2.3 2 0 0 2 2 2 0 Fz domain CorA PF01544.13 EFE43161.1 - 3.6e-42 144.4 0.0 4.6e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MFS_1 PF07690.11 EFE43162.1 - 3.8e-06 25.8 14.8 3.8e-06 25.8 10.3 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily DUF2561 PF10812.3 EFE43162.1 - 0.0076 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2561) DUF308 PF03729.8 EFE43162.1 - 0.015 15.2 4.9 0.015 15.2 3.4 2.8 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) DUF843 PF05814.6 EFE43162.1 - 0.022 14.5 1.1 0.56 10.0 0.1 2.5 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) DUF2721 PF11026.3 EFE43162.1 - 0.12 11.9 0.2 0.12 11.9 0.1 2.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2721) DUF4131 PF13567.1 EFE43162.1 - 0.44 9.9 7.8 3.5 7.0 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF202 PF02656.10 EFE43162.1 - 3.9 7.7 15.9 13 6.0 0.3 4.3 1 1 2 3 3 3 0 Domain of unknown function (DUF202) RRM_1 PF00076.17 EFE43163.1 - 2e-40 136.2 0.4 2e-18 65.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE43163.1 - 1.3e-32 111.6 0.1 1.5e-17 63.3 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.1 EFE43163.1 - 2.9e-30 104.3 1.0 8e-30 102.9 0.2 2.2 2 0 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_5 PF13893.1 EFE43163.1 - 1.3e-22 79.4 0.0 4.2e-09 36.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFE43163.1 - 0.029 14.2 0.0 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 RNA binding motif HAUS-augmin3 PF14932.1 EFE43164.1 - 0.0051 16.0 3.8 0.0083 15.3 2.7 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF4559 PF15112.1 EFE43164.1 - 0.043 12.9 2.4 0.073 12.2 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) GrpE PF01025.14 EFE43164.1 - 1.3 8.4 5.8 32 4.0 3.0 2.6 2 1 1 3 3 3 0 GrpE ADIP PF11559.3 EFE43164.1 - 1.4 8.8 7.0 2.3 8.1 4.9 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF1180 PF06679.7 EFE43166.1 - 0.2 11.5 3.9 0.91 9.3 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) PP2C PF00481.16 EFE43167.1 - 6.4e-33 114.2 0.0 7.7e-27 94.2 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 EFE43167.1 - 0.0027 17.1 0.1 0.0073 15.7 0.0 1.7 2 0 0 2 2 2 1 Protein phosphatase 2C CDP-OH_P_transf PF01066.16 EFE43168.1 - 9e-17 61.2 7.1 1.7e-16 60.3 4.8 1.7 1 1 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Methyltransf_23 PF13489.1 EFE43169.1 - 2.1e-10 40.5 0.0 4e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE43169.1 - 0.094 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 EFE43169.1 - 0.1 13.1 0.0 0.38 11.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Ribosomal_S9 PF00380.14 EFE43170.1 - 6.4e-31 107.1 0.1 6.4e-31 107.1 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S9/S16 EF1G PF00647.14 EFE43171.1 - 2.2e-48 162.4 0.2 3.5e-48 161.7 0.2 1.3 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 EFE43171.1 - 1.7e-11 43.9 0.0 4.1e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFE43171.1 - 4e-09 36.2 0.0 8.9e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE43171.1 - 6.3e-06 26.5 0.0 1.3e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF2360 PF10152.4 EFE43171.1 - 0.0043 17.3 0.3 0.0059 16.9 0.2 1.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein (DUF2360) NIF PF03031.13 EFE43172.1 - 1.1e-24 86.9 3.5 3.9e-24 85.1 2.4 1.9 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase DUF947 PF06102.7 EFE43173.1 - 6.1e-39 133.5 37.2 6.1e-39 133.5 25.8 2.8 1 1 1 2 2 2 1 Domain of unknown function (DUF947) Fer4_6 PF12837.2 EFE43175.1 - 0.23 11.3 3.4 11 6.0 0.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain FGF-BP1 PF06473.7 EFE43179.1 - 0.022 14.3 4.1 0.029 13.9 2.8 1.0 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Pox_Ag35 PF03286.9 EFE43179.1 - 0.064 12.7 2.9 0.07 12.6 2.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein UPF0561 PF10573.4 EFE43179.1 - 0.094 12.5 2.3 0.11 12.3 1.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 AUX_IAA PF02309.11 EFE43179.1 - 0.096 12.4 1.7 0.11 12.2 1.2 1.1 1 0 0 1 1 1 0 AUX/IAA family DUF3504 PF12012.3 EFE43179.1 - 0.14 11.9 0.9 0.16 11.7 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) Pkinase PF00069.20 EFE43180.1 - 1.4e-57 194.7 0.0 1.9e-57 194.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43180.1 - 1.1e-30 106.6 0.0 1.3e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE43180.1 - 0.003 16.5 0.0 0.011 14.6 0.0 1.8 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 EFE43180.1 - 0.0077 15.9 0.0 0.021 14.5 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE43180.1 - 0.091 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 EFE43180.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FSH1 PF03959.8 EFE43184.1 - 4.7e-67 225.5 0.0 6.4e-67 225.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 EFE43184.1 - 2.5e-09 37.3 0.0 6.3e-09 36.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE43184.1 - 2.2e-07 30.7 0.0 3.6e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 EFE43184.1 - 0.0064 15.8 0.0 0.19 10.9 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.11 EFE43184.1 - 0.11 11.9 0.1 8.6 5.7 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase PCI PF01399.22 EFE43185.1 - 3.2e-22 78.8 0.0 1.1e-21 77.1 0.0 1.9 1 0 0 1 1 1 1 PCI domain Asp_Glu_race_2 PF14669.1 EFE43185.1 - 0.00037 19.8 0.4 0.16 11.2 0.0 2.4 2 0 0 2 2 2 2 Putative aspartate racemase DASH_Dad3 PF08656.5 EFE43185.1 - 0.073 12.7 2.9 0.058 13.0 0.5 1.9 2 0 0 2 2 2 0 DASH complex subunit Dad3 CLTH PF10607.4 EFE43185.1 - 0.1 12.3 2.9 2.1 8.0 2.0 2.7 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain TP_methylase PF00590.15 EFE43186.1 - 1.9e-44 151.9 0.1 5.2e-44 150.4 0.0 1.7 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_C PF14823.1 EFE43186.1 - 3.8e-08 32.5 0.0 0.00054 19.2 0.0 2.3 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.1 EFE43186.1 - 0.0019 18.4 0.0 0.0042 17.3 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding DeoC PF01791.4 EFE43187.1 - 5.7e-43 146.8 3.0 6.9e-43 146.6 2.1 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase DHO_dh PF01180.16 EFE43187.1 - 8.7e-05 21.6 1.6 0.00013 20.9 1.1 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 EFE43187.1 - 0.0063 15.3 1.8 0.029 13.2 1.2 1.9 1 1 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 EFE43187.1 - 0.023 13.9 0.4 0.044 13.0 0.3 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein WD40 PF00400.27 EFE43189.1 - 1.5e-12 46.9 8.8 5.5e-06 26.0 0.1 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EFE43189.1 - 0.023 13.4 2.5 0.18 10.5 1.8 2.1 1 1 0 1 1 1 0 Nup133 N terminal like Gryzun-like PF12742.2 EFE43189.1 - 0.09 12.5 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking CorA PF01544.13 EFE43189.1 - 0.4 9.6 2.6 0.62 9.0 1.8 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Nucleoplasmin PF03066.10 EFE43189.1 - 3.9 6.9 7.3 7.4 6.0 5.1 1.5 1 0 0 1 1 1 0 Nucleoplasmin Radical_SAM PF04055.16 EFE43190.1 - 6e-13 49.3 0.0 1.1e-12 48.4 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily HAD PF12710.2 EFE43191.1 - 1.9e-13 51.0 0.1 3.2e-13 50.2 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFE43191.1 - 1.9e-12 48.0 0.1 1.1e-11 45.5 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE43191.1 - 1.1e-07 31.6 0.0 1.2e-06 28.3 0.0 2.3 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFE43191.1 - 2.1e-05 24.8 0.1 0.012 15.7 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 EFE43191.1 - 0.0016 17.6 0.0 0.045 12.9 0.0 2.3 2 0 0 2 2 2 1 Putative Phosphatase DUF347 PF03988.7 EFE43191.1 - 0.006 16.4 0.5 0.019 14.8 0.3 1.8 1 0 0 1 1 1 1 Repeat of Unknown Function (DUF347) DUF705 PF05152.7 EFE43191.1 - 0.021 13.8 0.3 0.03 13.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) PAPS_reduct PF01507.14 EFE43193.1 - 5.6e-43 146.7 0.0 8.9e-43 146.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ATP-synt_8 PF00895.15 EFE43193.1 - 0.99 9.6 12.3 0.23 11.6 2.6 2.4 2 0 0 2 2 2 0 ATP synthase protein 8 zf-DHHC PF01529.15 EFE43193.1 - 9.4 5.5 6.1 17 4.7 4.2 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase ATP-sulfurylase PF01747.12 EFE43194.1 - 2e-87 292.0 0.0 2.8e-87 291.5 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.15 EFE43194.1 - 3.6e-57 192.4 0.0 5.5e-57 191.8 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.1 EFE43194.1 - 2.1e-49 166.9 0.0 3.5e-49 166.2 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain EGF_CA PF07645.10 EFE43196.1 - 0.99 9.4 5.6 2.1 8.3 3.9 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain hEGF PF12661.2 EFE43196.1 - 3.8 7.7 7.3 0.82 9.8 2.6 1.8 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.8 EFE43196.1 - 7.8 6.7 9.1 16 5.7 6.3 1.6 1 0 0 1 1 1 0 EGF-like domain DUF2043 PF09740.4 EFE43197.1 - 0.061 13.4 0.8 0.059 13.4 0.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) Protocadherin PF08374.6 EFE43197.1 - 6.5 6.3 9.9 8.4 5.9 6.8 1.1 1 0 0 1 1 1 0 Protocadherin RP-C_C PF11800.3 EFE43199.1 - 0.1 12.2 0.6 0.094 12.4 0.4 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF3498 PF12004.3 EFE43200.1 - 0.82 8.7 12.9 0.77 8.8 8.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3498) PMC2NT PF08066.7 EFE43202.1 - 0.016 15.4 0.2 0.038 14.2 0.2 1.6 1 1 1 2 2 2 0 PMC2NT (NUC016) domain SET PF00856.23 EFE43204.1 - 6.8e-17 62.2 0.2 6.8e-17 62.2 0.2 3.0 3 1 0 3 3 3 1 SET domain zf-DHHC PF01529.15 EFE43205.1 - 4.2e-35 120.6 6.3 4.2e-35 120.6 4.3 1.9 1 1 1 2 2 2 1 DHHC palmitoyltransferase PMT PF02366.13 EFE43207.1 - 2.9e-75 252.8 15.5 2.9e-75 252.8 10.7 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EFE43207.1 - 6.1e-54 182.4 0.0 9.4e-54 181.8 0.0 1.3 1 0 0 1 1 1 1 MIR domain Arteri_Gl PF00951.13 EFE43207.1 - 0.0019 17.8 1.6 0.0038 16.8 1.1 1.4 1 0 0 1 1 1 1 Arterivirus GL envelope glycoprotein PRP21_like_P PF12230.3 EFE43208.1 - 2e-58 197.6 13.0 5.6e-56 189.6 9.0 2.4 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 EFE43208.1 - 1.7e-26 91.6 2.9 1.8e-16 59.5 0.3 2.3 2 0 0 2 2 2 2 Surp module UPF0547 PF10571.4 EFE43208.1 - 0.065 12.9 0.5 0.12 12.0 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Sec2p PF06428.6 EFE43209.1 - 1e-27 95.8 16.9 4.6e-27 93.8 11.7 2.0 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF3584 PF12128.3 EFE43209.1 - 0.18 9.0 17.3 0.25 8.6 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ScpA_ScpB PF02616.9 EFE43209.1 - 0.22 11.0 10.2 0.39 10.2 7.1 1.3 1 0 0 1 1 1 0 ScpA/B protein IncA PF04156.9 EFE43209.1 - 0.85 9.1 14.3 1.6 8.2 9.9 1.4 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.4 EFE43209.1 - 6.1 5.6 15.1 6.9 5.5 9.7 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 OsmC PF02566.14 EFE43210.1 - 0.13 12.4 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 OsmC-like protein dsDNA_bind PF01984.15 EFE43211.1 - 4.5e-34 116.6 9.9 5.4e-34 116.4 6.8 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF4615 PF15393.1 EFE43211.1 - 0.035 14.3 0.6 0.055 13.7 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4615) Coq4 PF05019.8 EFE43212.1 - 2.8e-77 258.5 0.0 3.2e-77 258.3 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 ApbA_C PF08546.6 EFE43213.1 - 3.1e-30 104.7 0.0 4.9e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EFE43213.1 - 6.1e-25 87.4 0.0 1.8e-23 82.6 0.0 2.2 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 EFE43213.1 - 0.099 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 ThiF family AAA_33 PF13671.1 EFE43213.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sas10_Utp3 PF04000.10 EFE43214.1 - 3e-16 59.3 1.0 7.6e-16 58.0 0.7 1.7 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Nucleo_P87 PF07267.6 EFE43214.1 - 0.063 11.9 10.3 0.071 11.7 7.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Roughex PF06020.6 EFE43214.1 - 0.23 10.1 7.6 0.33 9.6 5.3 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Merozoite_SPAM PF07133.6 EFE43214.1 - 0.49 10.2 23.7 0.99 9.2 16.4 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop14 PF04147.7 EFE43214.1 - 1.3 6.8 28.3 1.7 6.5 19.6 1.2 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 EFE43214.1 - 3.2 6.1 30.5 4.2 5.7 21.2 1.1 1 0 0 1 1 1 0 Daxx Family DUF2076 PF09849.4 EFE43215.1 - 5.5e-08 33.1 9.7 7e-08 32.8 6.7 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 EFE43215.1 - 4.6e-05 23.2 2.5 7e-05 22.6 1.7 1.3 1 0 0 1 1 1 1 CHCH domain TFIIA PF03153.8 EFE43215.1 - 7.8 6.2 7.8 11 5.7 5.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UBX PF00789.15 EFE43216.1 - 1.8e-09 37.5 0.0 3.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 UBX domain SIMPL PF04402.9 EFE43216.1 - 0.0067 16.3 2.5 0.0067 16.3 1.7 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF541) CAF-1_p150 PF11600.3 EFE43216.1 - 0.12 11.7 22.9 0.011 15.1 11.7 2.0 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Hamartin PF04388.7 EFE43216.1 - 9.8 4.7 14.3 0.63 8.6 6.4 1.5 2 0 0 2 2 2 0 Hamartin protein SURF1 PF02104.10 EFE43217.1 - 1.1e-65 221.4 0.0 1.6e-65 220.8 0.0 1.3 1 0 0 1 1 1 1 SURF1 family CENP-T PF15511.1 EFE43218.1 - 3.9e-84 283.2 14.9 4.6e-84 283.0 10.3 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T CENP-S PF15630.1 EFE43218.1 - 1.1e-07 31.8 0.1 2e-07 31.0 0.1 1.4 1 0 0 1 1 1 1 Kinetochore component CENP-S Histone PF00125.19 EFE43218.1 - 1.6e-05 24.9 0.1 2.4e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFE43218.1 - 8.9e-05 22.4 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bombolitin PF08096.6 EFE43218.1 - 0.025 14.6 0.1 0.048 13.7 0.1 1.5 1 0 0 1 1 1 0 Bombolitin family CENP-X PF09415.5 EFE43218.1 - 0.042 13.6 0.7 0.16 11.7 0.0 2.1 2 0 0 2 2 2 0 CENP-S associating Centromere protein X CMS1 PF14617.1 EFE43219.1 - 1.4e-78 263.4 1.0 1.8e-78 263.1 0.7 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.24 EFE43219.1 - 7.8e-05 22.2 0.0 9.5e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase RRM_1 PF00076.17 EFE43220.1 - 8.9e-12 44.4 0.0 2.7e-11 42.9 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE43220.1 - 6.8e-11 42.0 0.0 1.3e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE43220.1 - 0.0066 16.2 0.3 0.02 14.7 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ndc1_Nup PF09531.5 EFE43220.1 - 1.5 7.1 9.1 2.4 6.4 6.3 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ras PF00071.17 EFE43221.1 - 6.9e-39 132.8 0.0 9.2e-39 132.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE43221.1 - 4.4e-11 43.3 0.0 7.3e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE43221.1 - 0.011 15.0 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family RhoGAP PF00620.22 EFE43222.1 - 7.5e-46 155.4 0.0 1.9e-45 154.2 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.18 EFE43222.1 - 7.9e-14 51.6 2.2 2.1e-13 50.2 0.2 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain HrpA_pilin PF09589.5 EFE43222.1 - 0.22 11.9 3.1 0.61 10.5 2.2 1.8 1 0 0 1 1 1 0 HrpA pilus formation protein SSF PF00474.12 EFE43223.1 - 6.6e-09 34.8 30.8 3.3e-08 32.5 21.3 2.1 1 1 0 1 1 1 1 Sodium:solute symporter family MBA1 PF07961.6 EFE43224.1 - 7.7e-09 34.7 0.3 1.5e-08 33.8 0.2 1.4 1 1 0 1 1 1 1 MBA1-like protein Tim44 PF04280.10 EFE43224.1 - 0.081 12.9 0.0 0.46 10.4 0.0 2.1 1 1 0 1 1 1 0 Tim44-like domain SUI1 PF01253.17 EFE43225.1 - 2e-28 98.0 6.8 8.8e-28 95.9 4.5 2.1 2 0 0 2 2 2 1 Translation initiation factor SUI1 TPR_12 PF13424.1 EFE43225.1 - 0.00066 19.5 0.2 0.021 14.7 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFE43225.1 - 0.00095 19.4 0.5 0.025 14.9 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.4 EFE43225.1 - 0.033 14.1 0.3 0.16 11.9 0.0 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc5 PF12862.2 EFE43226.1 - 8.7e-32 108.8 0.4 2e-31 107.6 0.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 DUF3873 PF12989.2 EFE43226.1 - 0.23 11.6 1.3 6.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) Ribosomal_L19e PF01280.15 EFE43226.1 - 0.48 10.1 7.7 1 9.1 5.3 1.5 1 0 0 1 1 1 0 Ribosomal protein L19e SAICAR_synt PF01259.13 EFE43227.1 - 4e-82 275.0 0.0 4.8e-82 274.7 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase CIA30 PF08547.7 EFE43228.1 - 4.5e-37 127.3 0.1 7.2e-24 84.4 0.0 2.4 3 0 0 3 3 3 2 Complex I intermediate-associated protein 30 (CIA30) Med12 PF09497.5 EFE43229.1 - 8.4e-28 96.1 0.1 2.5e-27 94.6 0.1 1.9 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 SKG6 PF08693.5 EFE43230.1 - 0.015 14.6 0.3 0.03 13.6 0.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Mid2 PF04478.7 EFE43230.1 - 0.039 13.3 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF347 PF03988.7 EFE43230.1 - 0.13 12.1 0.3 0.23 11.3 0.2 1.3 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Hemerythrin PF01814.18 EFE43231.1 - 5.9e-14 52.3 0.2 8.2e-14 51.9 0.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF2404 PF10296.4 EFE43232.1 - 3.9e-29 100.6 0.0 7e-29 99.8 0.0 1.4 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) I_LWEQ PF01608.12 EFE43233.1 - 2.6e-64 215.7 7.8 2.6e-64 215.7 5.4 5.6 5 2 0 6 6 6 1 I/LWEQ domain ANTH PF07651.11 EFE43233.1 - 1.1e-43 148.9 0.0 1.1e-43 148.9 0.0 2.8 2 1 0 2 2 2 1 ANTH domain FlaC_arch PF05377.6 EFE43233.1 - 7.1 6.6 11.8 6.2 6.8 0.1 4.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) COX6A PF02046.10 EFE43234.1 - 4.9e-47 158.6 1.3 5.7e-47 158.4 0.9 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Exo_endo_phos_2 PF14529.1 EFE43235.1 - 6.4e-10 38.6 0.1 2.1e-08 33.7 0.0 3.0 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 EFE43235.1 - 9.4e-09 35.5 0.0 1.7e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.7 EFE43235.1 - 0.0038 17.1 0.2 0.0096 15.8 0.1 1.7 1 0 0 1 1 1 1 GRF zinc finger Acetone_carb_G PF08882.6 EFE43236.1 - 0.034 14.1 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit Toxin_YhaV PF11663.3 EFE43236.1 - 0.14 11.9 0.1 2.7 7.7 0.1 2.2 2 0 0 2 2 2 0 Toxin with endonuclease activity YhaV HMG_box PF00505.14 EFE43237.1 - 3.8e-16 59.1 4.4 3.1e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 EFE43237.1 - 0.0021 18.4 1.9 0.31 11.4 0.5 2.3 2 0 0 2 2 2 2 HMG-box domain Hexose_dehydrat PF03559.9 EFE43238.1 - 0.014 14.4 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase Ribosomal_S4e PF00900.15 EFE43239.1 - 1.4e-27 95.1 1.1 5.9e-21 73.9 0.0 2.5 2 0 0 2 2 2 2 Ribosomal family S4e S4 PF01479.20 EFE43239.1 - 0.0043 16.4 0.0 0.0088 15.4 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 EFE43239.1 - 0.0081 15.8 0.9 0.0081 15.8 0.6 3.3 4 0 0 4 4 4 1 KOW motif FAD-oxidase_C PF02913.14 EFE43240.1 - 2.1e-57 194.2 0.0 2.9e-57 193.8 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EFE43240.1 - 2.5e-20 72.3 0.0 7.6e-20 70.8 0.0 1.8 1 0 0 1 1 1 1 FAD binding domain Sulfate_transp PF00916.15 EFE43241.1 - 9.4e-80 267.5 8.6 1.5e-79 266.8 6.0 1.3 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 EFE43241.1 - 5e-30 103.0 2.5 5e-30 103.0 1.8 2.8 3 0 0 3 3 3 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EFE43241.1 - 5.2e-08 32.3 0.0 1.1e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 STAS domain PrgI PF12666.2 EFE43242.1 - 0.036 14.2 0.1 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 PrgI family protein DDE_Tnp_1_assoc PF13808.1 EFE43242.1 - 0.13 11.9 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 DDE_Tnp_1-associated Pkinase PF00069.20 EFE43243.1 - 1.8e-54 184.6 0.0 2.9e-54 183.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43243.1 - 1.6e-23 83.0 0.0 1.1e-22 80.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EFE43243.1 - 0.013 14.2 0.2 0.02 13.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.1 EFE43243.1 - 0.039 12.9 0.0 0.87 8.4 0.0 2.4 2 1 0 2 2 2 0 Kinase-like TMA7 PF09072.5 EFE43244.1 - 1.4e-22 79.8 21.2 1.4e-22 79.8 14.7 1.6 2 0 0 2 2 2 1 Translation machinery associated TMA7 RNA_pol_Rpc4 PF05132.9 EFE43244.1 - 0.62 10.0 4.1 0.94 9.4 2.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Fib_alpha PF08702.5 EFE43245.1 - 0.0048 17.0 0.7 0.01 15.9 0.5 1.6 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.7 EFE43245.1 - 0.059 13.1 0.7 0.11 12.3 0.5 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Filament PF00038.16 EFE43245.1 - 0.062 12.7 0.2 0.085 12.3 0.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein DHC_N2 PF08393.8 EFE43245.1 - 0.12 10.8 0.4 0.17 10.3 0.3 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 Cyt-b5 PF00173.23 EFE43246.1 - 5.2e-15 55.0 0.0 6.9e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ish1 PF10281.4 EFE43247.1 - 5.6e-77 253.3 16.9 1.3e-14 53.8 0.0 7.6 7 0 0 7 7 7 7 Putative stress-responsive nuclear envelope protein HeH PF12949.2 EFE43247.1 - 1.5e-09 37.2 0.4 1.2 8.7 0.0 5.3 5 0 0 5 5 5 4 HeH/LEM domain SAP PF02037.22 EFE43247.1 - 1.4e-06 27.6 0.0 0.44 10.1 0.0 4.4 4 0 0 4 4 4 2 SAP domain Slx4 PF09494.5 EFE43247.1 - 2.9e-05 23.7 0.2 7.8 6.3 0.0 5.0 6 0 0 6 6 6 2 Slx4 endonuclease APC2 PF08672.6 EFE43247.1 - 0.00058 20.0 2.2 30 4.9 0.0 5.7 6 0 0 6 6 6 0 Anaphase promoting complex (APC) subunit 2 LEM PF03020.10 EFE43247.1 - 0.066 12.6 0.0 52 3.4 0.0 3.9 4 0 0 4 4 4 0 LEM domain Isochorismatase PF00857.15 EFE43247.1 - 0.11 12.3 0.2 38 4.1 0.0 3.9 5 0 0 5 5 5 0 Isochorismatase family Recombinase PF07508.8 EFE43247.1 - 0.15 12.2 2.5 4.4 7.5 0.0 3.6 3 1 1 4 4 4 0 Recombinase PQ-loop PF04193.9 EFE43248.1 - 5.2e-19 67.5 16.9 1e-11 44.1 2.5 3.7 4 0 0 4 4 4 2 PQ loop repeat Arteri_GP4 PF02497.10 EFE43248.1 - 0.037 13.9 0.1 0.079 12.8 0.1 1.5 1 1 0 1 1 1 0 Arterivirus glycoprotein TrbC PF04956.8 EFE43248.1 - 0.057 13.4 4.5 0.11 12.5 2.4 2.1 1 1 1 2 2 2 0 TrbC/VIRB2 family DUF4231 PF14015.1 EFE43248.1 - 0.25 11.3 6.1 0.19 11.7 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) ATP-synt_8 PF00895.15 EFE43248.1 - 0.28 11.4 1.8 5.6 7.2 0.2 3.0 3 0 0 3 3 3 0 ATP synthase protein 8 OppC_N PF12911.2 EFE43248.1 - 0.7 9.2 5.7 0.9 8.9 0.0 3.1 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DUF2489 PF10675.4 EFE43249.1 - 0.055 13.1 1.9 0.072 12.7 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) CCDC-167 PF15188.1 EFE43249.1 - 2.9 7.8 9.4 2.8 7.9 4.0 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF2951 PF11166.3 EFE43250.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) CDC45 PF02724.9 EFE43251.1 - 2 6.3 7.8 2 6.3 5.4 1.0 1 0 0 1 1 1 0 CDC45-like protein MAGE_N PF12440.3 EFE43252.1 - 8.8 6.6 9.5 2.3 8.5 0.4 2.7 3 0 0 3 3 3 0 Melanoma associated antigen family N terminal FAD_binding_4 PF01565.18 EFE43253.1 - 2.2e-15 56.3 3.9 4.2e-15 55.4 2.7 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE43253.1 - 3.1e-07 30.1 0.1 6.5e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF3210 PF11489.3 EFE43254.1 - 3.7e-96 323.4 67.7 3.7e-96 323.4 46.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3210) DUF3210 PF11489.3 EFE43255.1 - 3.7e-66 224.2 23.4 3.7e-66 224.2 16.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3210) Cg6151-P PF10233.4 EFE43256.1 - 1.4e-35 121.6 11.2 2e-35 121.1 7.8 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Dpy19 PF10034.4 EFE43256.1 - 0.03 12.5 5.3 0.037 12.2 3.7 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF2721 PF11026.3 EFE43256.1 - 6.3 6.4 11.0 0.86 9.2 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Macoilin PF09726.4 EFE43257.1 - 0.3 9.3 14.1 0.51 8.5 9.8 1.3 1 0 0 1 1 1 0 Transmembrane protein BNR PF02012.15 EFE43258.1 - 2.2e-08 32.6 26.0 0.92 9.5 0.0 9.6 10 0 0 10 10 10 6 BNR/Asp-box repeat Transp_cyt_pur PF02133.10 EFE43259.1 - 1.5e-70 238.0 33.2 1.3e-42 145.9 3.5 2.6 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin Mito_carr PF00153.22 EFE43260.1 - 2.1e-67 222.8 0.5 9e-24 83.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Cgr1 PF03879.9 EFE43261.1 - 5.2e-38 129.5 31.7 5.2e-38 129.5 22.0 2.6 3 0 0 3 3 3 1 Cgr1 family Cnd1_N PF12922.2 EFE43261.1 - 0.022 14.3 0.4 0.022 14.3 0.3 2.5 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1, N-term DUF3357 PF11837.3 EFE43261.1 - 1.1 9.1 0.0 1.1 9.1 0.0 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF3357) Hid1 PF12722.2 EFE43261.1 - 7.6 4.0 11.0 11 3.5 7.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SUI1 PF01253.17 EFE43263.1 - 2.1e-22 78.6 0.3 3.8e-22 77.8 0.2 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 TnpV PF14198.1 EFE43263.1 - 0.0028 17.5 0.1 0.0051 16.6 0.1 1.4 1 0 0 1 1 1 1 Transposon-encoded protein TnpV SRP14 PF02290.10 EFE43263.1 - 0.024 14.5 0.3 0.043 13.7 0.2 1.5 1 0 0 1 1 1 0 Signal recognition particle 14kD protein DUF1752 PF08550.5 EFE43264.1 - 5.9e-09 35.3 1.9 1.6e-08 33.9 1.3 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ELMO_CED12 PF04727.8 EFE43265.1 - 1.8e-49 167.5 0.1 3.2e-49 166.7 0.1 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.3 EFE43265.1 - 1.1e-05 25.1 0.5 0.00013 21.7 0.3 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3361) DUF4257 PF14074.1 EFE43265.1 - 0.071 12.7 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4257) FliD_N PF02465.13 EFE43265.1 - 0.085 13.2 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Rad17 PF03215.10 EFE43266.1 - 2.7e-54 184.7 0.0 4.5e-54 184.0 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 EFE43266.1 - 0.00072 20.3 0.5 0.0034 18.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFE43266.1 - 0.001 19.3 2.8 0.022 15.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE43266.1 - 0.0017 18.0 0.0 0.0043 16.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 EFE43266.1 - 0.0021 17.0 0.0 0.0051 15.7 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.1 EFE43266.1 - 0.0031 17.5 0.0 0.0072 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 EFE43266.1 - 0.0064 16.2 0.0 0.017 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 EFE43266.1 - 0.0073 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EFE43266.1 - 0.011 15.7 0.0 0.011 15.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EFE43266.1 - 0.021 15.1 1.4 0.87 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 EFE43266.1 - 0.022 14.9 0.1 0.065 13.4 0.0 1.8 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE43266.1 - 0.043 13.9 0.0 0.095 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFE43266.1 - 0.065 13.1 0.7 0.36 10.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EFE43266.1 - 0.21 10.4 0.0 0.34 9.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain UAA PF08449.6 EFE43267.1 - 2.9e-69 233.3 12.9 4.2e-69 232.7 9.0 1.2 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 EFE43267.1 - 0.00012 21.7 13.6 0.00012 21.7 9.4 3.0 2 1 0 2 2 2 1 Triose-phosphate Transporter family DUF791 PF05631.9 EFE43268.1 - 3.7e-42 144.2 5.4 4.9e-42 143.9 3.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF791) MFS_1 PF07690.11 EFE43268.1 - 5.8e-16 58.1 16.5 1.1e-15 57.2 11.4 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE43268.1 - 3.5e-10 39.0 9.1 5.1e-10 38.5 6.3 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.2 EFE43268.1 - 0.0057 16.4 0.5 0.038 13.7 0.0 2.5 3 0 0 3 3 3 1 MFS_1 like family MFS_2 PF13347.1 EFE43268.1 - 0.014 13.7 11.0 0.01 14.2 6.7 1.5 1 1 0 1 1 1 0 MFS/sugar transport protein Claudin_2 PF13903.1 EFE43268.1 - 0.033 13.8 10.0 0.033 13.8 0.4 2.3 1 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction TetR_C_2 PF08361.6 EFE43268.1 - 0.035 14.0 0.0 10 6.0 0.0 2.3 2 0 0 2 2 2 0 MAATS-type transcriptional repressor, C-terminal region ATG22 PF11700.3 EFE43268.1 - 0.17 10.2 11.1 0.53 8.6 7.7 1.7 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like DUF791 PF05631.9 EFE43269.1 - 8.8e-11 41.0 0.3 1.2e-10 40.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF791) Speriolin_N PF15058.1 EFE43269.1 - 0.2 11.5 4.9 0.28 11.0 3.4 1.1 1 0 0 1 1 1 0 Speriolin N terminus MFS_1 PF07690.11 EFE43269.1 - 0.59 8.7 8.0 0.084 11.5 2.1 1.8 2 0 0 2 2 2 0 Major Facilitator Superfamily Hydrolase_6 PF13344.1 EFE43270.1 - 7.4e-21 73.9 0.0 2e-20 72.5 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE43270.1 - 4.1e-16 58.4 0.0 9.8e-16 57.2 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 EFE43270.1 - 0.0067 16.6 0.0 1.5 9.0 0.0 2.8 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFE43270.1 - 0.017 15.5 0.0 0.64 10.3 0.0 2.7 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase Apt1 PF10351.4 EFE43270.1 - 0.079 11.8 0.4 0.12 11.1 0.0 1.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain Aldo_ket_red PF00248.16 EFE43271.1 - 4e-57 193.1 0.0 4.8e-57 192.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TnpV PF14198.1 EFE43271.1 - 0.0068 16.2 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Transposon-encoded protein TnpV DUF3818 PF12825.2 EFE43273.1 - 6.8e-128 426.1 7.4 3.3e-119 397.5 4.1 2.2 2 0 0 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 EFE43273.1 - 5.6e-37 126.4 0.2 1.2e-36 125.3 0.1 1.5 1 0 0 1 1 1 1 PX-associated PX PF00787.19 EFE43273.1 - 4.1e-14 52.3 1.0 6.1e-13 48.5 0.0 3.2 3 1 0 3 3 3 1 PX domain Met_10 PF02475.11 EFE43276.1 - 7.8e-64 214.9 0.0 1.3e-63 214.2 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein RNA_pol_Rpb4 PF03874.11 EFE43277.1 - 2.4e-22 79.1 0.9 3.6e-22 78.5 0.6 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb4 POTRA_2 PF08479.6 EFE43277.1 - 0.026 14.1 0.0 2.2 8.0 0.0 2.4 2 0 0 2 2 2 0 POTRA domain, ShlB-type DUF4102 PF13356.1 EFE43277.1 - 0.088 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4102) AMP-binding PF00501.23 EFE43278.1 - 3.7e-69 233.1 0.0 6e-69 232.4 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE43278.1 - 1.3e-05 26.0 0.0 2.5e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RhoGAP PF00620.22 EFE43279.1 - 3.6e-33 114.3 0.1 7.2e-33 113.3 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.17 EFE43279.1 - 7.6e-29 99.5 34.5 3.6e-12 46.1 4.6 5.0 5 0 0 5 5 5 4 LIM domain UIM PF02809.15 EFE43281.1 - 0.0013 18.1 0.3 0.0027 17.1 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin interaction motif VWA_2 PF13519.1 EFE43281.1 - 0.03 14.4 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Phage_Gp23 PF10669.4 EFE43281.1 - 2 8.5 5.1 0.72 9.9 1.6 1.6 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) UQ_con PF00179.21 EFE43283.1 - 9e-15 54.3 0.0 4.7e-12 45.5 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme UQ_con PF00179.21 EFE43284.1 - 3.2e-09 36.3 0.0 4.8e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFE43284.1 - 0.00063 19.5 0.0 0.00092 18.9 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B Spore_III_AF PF09581.5 EFE43284.1 - 0.059 13.2 0.1 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) FGE-sulfatase PF03781.11 EFE43287.1 - 2.1e-31 109.2 0.1 3.5e-31 108.4 0.1 1.4 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.2 EFE43287.1 - 6.9e-08 32.8 0.3 1.8e-07 31.5 0.2 1.8 1 0 0 1 1 1 1 DinB superfamily Methyltransf_18 PF12847.2 EFE43287.1 - 3.7e-07 30.7 0.0 1.5e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE43287.1 - 0.00034 20.9 0.0 0.002 18.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE43287.1 - 0.00097 19.5 0.0 0.0064 16.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Gln-synt_C PF00120.19 EFE43288.1 - 1.7e-36 125.6 0.0 3.7e-36 124.6 0.0 1.5 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain IDO PF01231.13 EFE43289.1 - 6e-37 127.0 0.0 8.4e-37 126.5 0.0 1.3 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase APH PF01636.18 EFE43291.1 - 7e-11 42.3 0.0 7.5e-10 38.9 0.0 2.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family SH3_8 PF13457.1 EFE43291.1 - 0.056 13.5 0.2 0.13 12.3 0.2 1.6 1 0 0 1 1 1 0 SH3-like domain 3Beta_HSD PF01073.14 EFE43292.1 - 3.8e-46 157.0 0.0 4.9e-45 153.4 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFE43292.1 - 5.4e-17 62.0 0.1 7.4e-16 58.3 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFE43292.1 - 3.7e-12 45.7 0.0 4.2e-10 38.9 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.12 EFE43292.1 - 2.2e-05 23.5 0.0 9.3e-05 21.4 0.0 2.0 2 1 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 EFE43292.1 - 0.00069 19.6 0.0 0.013 15.5 0.0 2.1 2 0 0 2 2 2 1 NADH(P)-binding Pkinase PF00069.20 EFE43293.1 - 1.8e-61 207.6 0.0 8.6e-40 136.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43293.1 - 6.9e-29 100.7 0.0 5.1e-21 74.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.19 EFE43293.1 - 5.9e-12 45.5 0.0 1.4e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.1 EFE43293.1 - 5e-08 32.2 0.1 4.8e-06 25.7 0.0 2.8 3 0 0 3 3 3 1 Kinase-like APH PF01636.18 EFE43293.1 - 1.2e-05 25.1 0.1 0.0056 16.4 0.1 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 EFE43293.1 - 0.0046 16.0 0.0 0.0089 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_9 PF13426.1 EFE43293.1 - 0.013 15.9 0.0 0.038 14.3 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS PF00989.19 EFE43293.1 - 0.031 14.0 0.1 0.069 12.9 0.0 1.7 1 0 0 1 1 1 0 PAS fold Seadorna_VP7 PF07387.6 EFE43293.1 - 0.14 10.9 0.1 0.25 10.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 eIF-3_zeta PF05091.7 EFE43294.1 - 1.8e-187 624.0 0.0 2.2e-187 623.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) bZIP_1 PF00170.16 EFE43295.1 - 0.0031 17.4 9.6 0.0037 17.1 3.4 2.3 2 0 0 2 2 2 1 bZIP transcription factor Med9 PF07544.8 EFE43295.1 - 0.28 10.9 4.4 1.6 8.4 2.2 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 bZIP_2 PF07716.10 EFE43295.1 - 3.2 7.6 12.5 0.47 10.3 3.2 2.3 2 0 0 2 2 2 0 Basic region leucine zipper F-box-like PF12937.2 EFE43296.1 - 0.0029 17.2 1.3 0.0057 16.3 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EFE43296.1 - 0.11 12.2 0.4 0.31 10.7 0.3 1.9 1 0 0 1 1 1 0 F-box domain DUF3546 PF12066.3 EFE43298.1 - 1.6e-22 79.5 0.6 1.6e-22 79.5 0.4 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3546) DUF4187 PF13821.1 EFE43298.1 - 8.6e-22 76.4 0.0 2.3e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.8 EFE43298.1 - 9.1e-09 35.8 3.0 9.1e-09 35.8 2.0 1.8 1 1 0 1 1 1 1 Arsenite-resistance protein 2 DUF4153 PF13687.1 EFE43299.1 - 0.013 15.0 1.3 0.014 14.9 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4153) DUF2269 PF10027.4 EFE43299.1 - 0.018 14.8 0.0 0.021 14.6 0.0 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) DUF3366 PF11846.3 EFE43299.1 - 0.55 10.0 3.8 1 9.1 2.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3366) DUF2956 PF11169.3 EFE43300.1 - 0.0026 17.6 4.6 0.003 17.4 3.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2956) ATP-synt_E PF05680.7 EFE43300.1 - 0.0086 16.0 3.4 0.0098 15.8 2.4 1.1 1 0 0 1 1 1 1 ATP synthase E chain DUF2207 PF09972.4 EFE43300.1 - 0.014 13.9 1.8 0.015 13.8 1.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SLD3 PF08639.5 EFE43300.1 - 0.027 13.1 4.8 0.026 13.1 3.3 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 DUF912 PF06024.7 EFE43300.1 - 0.073 13.1 0.0 0.093 12.7 0.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PBP1_TM PF14812.1 EFE43300.1 - 0.13 12.5 5.4 0.2 12.0 3.7 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0233 PF06781.7 EFE43300.1 - 0.68 9.5 5.5 4.9 6.8 3.8 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0233) DUF1673 PF07895.6 EFE43300.1 - 1.2 8.6 4.1 2 7.8 2.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) BRF1 PF07741.8 EFE43300.1 - 2.4 8.4 12.1 2.9 8.1 8.4 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain SR-25 PF10500.4 EFE43300.1 - 3.7 6.9 18.1 4.3 6.7 12.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Protocadherin PF08374.6 EFE43300.1 - 6.2 6.3 8.6 7.3 6.1 6.0 1.1 1 0 0 1 1 1 0 Protocadherin CBFB_NFYA PF02045.10 EFE43302.1 - 8.2e-31 106.3 4.1 2.1e-30 105.0 2.9 1.7 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B K_channel_TID PF07941.6 EFE43302.1 - 0.067 13.4 0.4 0.067 13.4 0.3 3.5 4 0 0 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain Hus1 PF04005.7 EFE43302.1 - 0.14 11.0 0.0 0.14 11.0 0.0 1.6 2 0 0 2 2 2 0 Hus1-like protein Kinesin PF00225.18 EFE43304.1 - 1.7e-107 358.9 0.0 2.9e-107 358.2 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.3 EFE43304.1 - 2.3e-43 147.2 0.0 4.3e-43 146.3 0.0 1.5 1 0 0 1 1 1 1 Kinesin protein KIF1B PF12423.3 EFE43304.1 - 4.1e-07 29.9 1.9 5.1e-07 29.6 0.2 2.1 2 0 0 2 2 2 1 Kinesin protein 1B FHA PF00498.21 EFE43304.1 - 2.2e-06 27.6 0.4 2e-05 24.6 0.1 2.7 3 0 0 3 3 3 1 FHA domain PH PF00169.24 EFE43304.1 - 5.8e-06 26.4 0.0 3.6e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 PH domain 3-dmu-9_3-mt PF06983.8 EFE43305.1 - 9.4e-39 132.3 0.0 1.3e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase DSX_dimer PF08828.5 EFE43305.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Doublesex dimerisation domain Ham1p_like PF01725.11 EFE43306.1 - 3.4e-47 160.2 0.0 3.8e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Phosphodiest PF01663.17 EFE43307.1 - 7e-82 275.6 0.1 1e-81 275.1 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFE43307.1 - 0.00012 21.4 0.0 0.12 11.5 0.0 2.2 1 1 0 2 2 2 2 Sulfatase PglZ PF08665.7 EFE43307.1 - 0.0023 17.6 0.2 0.091 12.4 0.0 2.6 3 0 0 3 3 3 1 PglZ domain Metalloenzyme PF01676.13 EFE43307.1 - 0.055 12.8 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily HNH_2 PF13391.1 EFE43308.1 - 1.7e-10 40.4 0.0 4.6e-10 39.1 0.0 1.8 1 0 0 1 1 1 1 HNH endonuclease ATP-synt_E PF05680.7 EFE43308.1 - 0.098 12.6 9.8 2.4 8.1 0.2 2.9 3 0 0 3 3 3 0 ATP synthase E chain FAM165 PF14981.1 EFE43308.1 - 2.4 7.7 5.4 6.1 6.4 3.7 1.7 1 0 0 1 1 1 0 FAM165 family PHP PF02811.14 EFE43309.1 - 1.8e-06 27.8 0.0 1.7e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 PHP domain PHP_C PF13263.1 EFE43309.1 - 0.025 14.0 0.0 0.09 12.2 0.0 1.8 2 0 0 2 2 2 0 PHP-associated Herpes_US9 PF06072.6 EFE43310.1 - 0.0099 15.7 1.3 0.023 14.4 0.9 1.6 1 0 0 1 1 1 1 Alphaherpesvirus tegument protein US9 Fic PF02661.13 EFE43311.1 - 1.8e-10 41.3 0.2 3.6e-10 40.4 0.2 1.5 1 0 0 1 1 1 1 Fic/DOC family HLH PF00010.21 EFE43312.1 - 9.9e-16 57.1 1.8 1.5e-15 56.6 0.5 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF972 PF06156.8 EFE43312.1 - 7 7.0 16.1 1.5 9.1 5.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Ribosomal_S8e PF01201.17 EFE43313.1 - 2.3e-48 163.6 1.9 2.7e-48 163.4 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e Ribonuclease_T2 PF00445.13 EFE43314.1 - 8.7e-45 152.6 1.5 8.7e-45 152.6 1.1 1.4 2 0 0 2 2 2 1 Ribonuclease T2 family DUF1792 PF08759.6 EFE43314.1 - 0.0029 17.2 0.8 0.0044 16.6 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1792) Tissue_fac PF01108.12 EFE43314.1 - 0.72 9.6 5.5 2.2 8.0 0.1 2.4 1 1 1 2 2 2 0 Tissue factor SPX PF03105.14 EFE43315.1 - 1.2e-47 162.9 0.2 2.8e-47 161.7 0.2 1.6 1 1 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 EFE43315.1 - 3.8e-27 95.2 42.7 5.5e-27 94.7 29.6 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 EFE43315.1 - 1e-11 44.0 24.6 1e-11 44.0 17.0 2.5 1 1 2 3 3 3 2 Citrate transporter DUF3290 PF11694.3 EFE43315.1 - 0.13 12.0 0.0 0.13 12.0 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3290) Peptidase_S28 PF05577.7 EFE43316.1 - 5.6e-53 180.0 0.0 3.3e-52 177.5 0.0 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 EFE43316.1 - 0.012 15.5 0.0 0.022 14.6 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFE43316.1 - 0.029 13.5 0.1 0.073 12.2 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ribosomal_S7 PF00177.16 EFE43317.1 - 5.7e-29 100.6 0.0 1.1e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF1013 PF06242.6 EFE43317.1 - 0.061 13.3 0.4 0.31 11.0 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1013) Na_Ca_ex PF01699.19 EFE43318.1 - 4.9e-40 136.3 28.3 9.4e-23 80.3 7.3 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3810 PF12725.2 EFE43318.1 - 0.088 11.6 1.1 0.14 11.0 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) DUF2895 PF11444.3 EFE43318.1 - 0.17 11.0 0.0 0.32 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) DUF1352 PF07086.7 EFE43318.1 - 1.3 8.5 6.1 0.52 9.9 2.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1352) DUF3405 PF11885.3 EFE43320.1 - 1.9e-218 725.6 0.6 2.4e-218 725.3 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Sod_Cu PF00080.15 EFE43322.1 - 2.1e-11 44.1 1.0 7.5e-11 42.3 0.2 2.0 2 0 0 2 2 2 1 Copper/zinc superoxide dismutase (SODC) Voldacs PF03517.8 EFE43323.1 - 0.059 13.2 3.6 0.08 12.7 2.5 1.3 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Choline_kinase PF01633.15 EFE43324.1 - 2.2e-45 154.8 0.0 2.2e-44 151.5 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 EFE43324.1 - 2.2e-10 40.7 1.9 9.2e-10 38.6 0.1 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family CHORD PF04968.7 EFE43325.1 - 4.1e-52 174.2 17.8 6.9e-26 90.2 3.4 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.11 EFE43325.1 - 1.9e-13 50.7 0.1 3e-13 50.0 0.1 1.3 1 0 0 1 1 1 1 CS domain MGC-24 PF05283.6 EFE43325.1 - 5.4 6.7 10.3 9.9 5.9 7.1 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) DUF836 PF05768.9 EFE43326.1 - 2.6e-13 50.0 0.0 3.1e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 EFE43326.1 - 0.013 15.4 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin HpcH_HpaI PF03328.9 EFE43327.1 - 1.4e-29 102.6 0.0 5.2e-28 97.4 0.0 2.0 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP_mutase PF13714.1 EFE43327.1 - 0.013 14.7 0.2 2 7.5 0.0 2.5 2 0 0 2 2 2 0 Phosphoenolpyruvate phosphomutase Fungal_trans PF04082.13 EFE43328.1 - 7.1e-12 44.7 0.4 1.2e-11 43.9 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Acyl-CoA_dh_1 PF00441.19 EFE43329.1 - 1.1e-30 106.7 0.3 1.3e-30 106.5 0.2 1.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.6 EFE43329.1 - 1.1e-07 32.2 0.1 1.3e-07 31.9 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFE43330.1 - 6.2e-15 54.4 0.0 9.7e-15 53.8 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 EFE43330.1 - 1.8e-12 47.8 0.1 4.2e-12 46.6 0.1 1.6 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain 14-3-3 PF00244.15 EFE43331.1 - 2e-10 40.1 0.1 3.5e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 14-3-3 protein tRNA-synt_1b PF00579.20 EFE43332.1 - 1.6e-21 76.7 0.0 2e-20 73.1 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) APH PF01636.18 EFE43333.1 - 1.4e-14 54.3 0.2 2.3e-14 53.7 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.9 EFE43333.1 - 0.019 13.9 0.0 0.033 13.1 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase Metallophos PF00149.23 EFE43334.1 - 4.3e-09 36.0 1.4 9.4e-09 34.9 0.9 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TilS_C PF11734.3 EFE43334.1 - 0.005 16.0 0.4 3.2 7.0 0.1 3.5 3 0 0 3 3 3 2 TilS substrate C-terminal domain PBP1_TM PF14812.1 EFE43334.1 - 2.1 8.7 8.9 0.52 10.6 3.3 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PSI PF01437.20 EFE43335.1 - 3.2e-05 23.9 7.6 5.8e-05 23.1 5.3 1.5 1 0 0 1 1 1 1 Plexin repeat GRP PF07172.6 EFE43335.1 - 0.0007 20.0 8.5 0.001 19.4 5.9 1.2 1 0 0 1 1 1 1 Glycine rich protein family P12 PF12669.2 EFE43335.1 - 0.008 16.3 0.0 3.2 8.0 0.0 2.4 2 0 0 2 2 2 2 Virus attachment protein p12 family DUF1183 PF06682.7 EFE43335.1 - 0.037 13.6 0.1 0.046 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) DUF533 PF04391.7 EFE43335.1 - 0.82 9.0 3.5 0.82 9.0 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF533) EMP24_GP25L PF01105.19 EFE43336.1 - 1.1e-45 155.6 0.1 1.3e-45 155.3 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Y_Y_Y PF07495.8 EFE43336.1 - 0.052 13.3 0.1 0.12 12.1 0.1 1.6 1 1 0 1 1 1 0 Y_Y_Y domain NUDE_C PF04880.8 EFE43336.1 - 0.079 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Myb_DNA-bind_6 PF13921.1 EFE43337.1 - 0.0011 18.9 1.2 0.0083 16.2 0.3 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.4 EFE43337.1 - 0.22 11.7 1.5 0.68 10.1 0.7 2.0 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-binding PF00249.26 EFE43337.1 - 0.56 10.3 4.8 1.4 9.0 1.1 2.7 3 1 0 3 3 3 0 Myb-like DNA-binding domain Glyco_hydro_17 PF00332.13 EFE43338.1 - 9.9e-23 80.6 0.0 1e-21 77.3 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 LMBR1 PF04791.11 EFE43340.1 - 0.27 9.7 9.8 1.6 7.1 6.8 1.9 1 1 0 1 1 1 0 LMBR1-like membrane protein RNB PF00773.14 EFE43342.1 - 2.7e-78 263.5 0.1 1.2e-77 261.3 0.0 2.1 2 0 0 2 2 2 1 RNB domain UQ_con PF00179.21 EFE43343.1 - 5e-35 119.9 0.0 9.6e-35 119.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme EF1_GNE PF00736.14 EFE43345.1 - 2.6e-31 107.1 1.4 4.9e-31 106.2 1.0 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 EFE43345.1 - 1.7e-07 31.2 1.8 1.7e-07 31.2 1.3 2.1 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region DUF4604 PF15377.1 EFE43345.1 - 0.11 12.7 3.4 0.17 12.1 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) ANAPC15 PF15243.1 EFE43345.1 - 2.7 8.1 6.7 0.86 9.7 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 AAA_2 PF07724.9 EFE43346.1 - 3.8e-46 157.1 0.0 1.6e-44 151.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 EFE43346.1 - 1.7e-25 88.6 0.0 5.9e-25 86.9 0.0 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 EFE43346.1 - 9.9e-18 64.6 0.0 5.5e-09 36.3 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFE43346.1 - 2.4e-12 46.7 0.1 2.3e-07 30.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFE43346.1 - 1.7e-10 41.2 12.3 0.00012 22.1 0.0 5.5 4 2 2 6 6 6 3 AAA ATPase domain AAA_22 PF13401.1 EFE43346.1 - 2.4e-09 37.4 0.7 0.00073 19.6 0.0 3.4 3 1 0 3 3 3 2 AAA domain Sigma54_activat PF00158.21 EFE43346.1 - 1.2e-07 31.3 0.3 0.00028 20.3 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.1 EFE43346.1 - 8.3e-06 25.7 0.0 0.17 11.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EFE43346.1 - 1.6e-05 24.6 0.3 0.19 11.3 0.0 2.7 3 0 0 3 3 2 2 NACHT domain IstB_IS21 PF01695.12 EFE43346.1 - 3.9e-05 23.1 0.0 0.12 11.8 0.0 3.1 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_18 PF13238.1 EFE43346.1 - 0.00013 22.2 2.9 0.094 13.0 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_19 PF13245.1 EFE43346.1 - 0.00016 21.3 0.0 0.0083 15.8 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_25 PF13481.1 EFE43346.1 - 0.00018 20.9 0.1 0.098 12.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 EFE43346.1 - 0.00021 21.2 1.1 0.057 13.3 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_17 PF13207.1 EFE43346.1 - 0.00021 22.0 4.5 0.6 10.9 0.0 3.9 4 1 0 4 4 3 2 AAA domain MobB PF03205.9 EFE43346.1 - 0.00026 20.7 0.0 0.17 11.5 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 EFE43346.1 - 0.00037 20.2 7.4 0.13 11.8 0.0 4.5 3 2 0 3 3 3 1 Archaeal ATPase TrwB_AAD_bind PF10412.4 EFE43346.1 - 0.00086 18.0 0.1 0.16 10.5 0.0 2.5 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain SRP54 PF00448.17 EFE43346.1 - 0.0012 18.2 0.1 0.16 11.3 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain ResIII PF04851.10 EFE43346.1 - 0.0046 16.8 3.6 2.6 7.8 0.0 3.5 3 1 1 4 4 4 2 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 EFE43346.1 - 0.0052 16.9 0.1 2 8.6 0.0 2.8 2 1 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.16 EFE43346.1 - 0.0053 15.9 0.2 1.7 7.7 0.1 2.9 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 EFE43346.1 - 0.0077 16.5 1.1 0.49 10.6 0.0 2.9 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.1 EFE43346.1 - 0.0098 15.7 0.1 5.9 6.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EFE43346.1 - 0.012 15.1 0.0 0.52 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EFE43346.1 - 0.012 15.0 0.0 0.61 9.5 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 EFE43346.1 - 0.015 14.8 1.7 0.26 10.8 0.0 3.5 5 0 0 5 5 4 0 AAA domain Zeta_toxin PF06414.7 EFE43346.1 - 0.016 14.3 0.0 0.49 9.4 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin DUF815 PF05673.8 EFE43346.1 - 0.023 13.6 0.2 0.67 8.8 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF815) Miro PF08477.8 EFE43346.1 - 0.034 14.6 0.1 2.9 8.4 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein DUF258 PF03193.11 EFE43346.1 - 0.037 13.2 0.0 4.4 6.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ERM PF00769.14 EFE43346.1 - 0.062 12.8 10.7 0.12 11.9 7.4 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family UvrD-helicase PF00580.16 EFE43346.1 - 0.066 12.5 2.5 0.4 9.9 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain UPF0079 PF02367.12 EFE43346.1 - 0.11 12.1 0.1 24 4.5 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ATP_bind_1 PF03029.12 EFE43346.1 - 0.13 11.7 0.1 2.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 EFE43346.1 - 0.87 8.9 4.1 0.99 8.7 0.0 2.8 3 2 0 3 3 3 0 AAA-like domain MutS_III PF05192.13 EFE43347.1 - 8.3e-19 68.1 0.0 1.3e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 MutS domain III MutS_V PF00488.16 EFE43347.1 - 4.2e-10 39.4 0.0 8.7e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_IV PF05190.13 EFE43347.1 - 0.027 14.6 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 MutS family domain IV Sas10 PF09368.5 EFE43348.1 - 8.3e-29 99.5 6.8 8.3e-29 99.5 4.7 4.1 4 1 1 5 5 5 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 EFE43348.1 - 5.3e-13 48.9 0.1 2.2e-12 47.0 0.0 2.2 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Ribosomal_S6 PF01250.12 EFE43348.1 - 0.14 12.0 2.7 6.1 6.7 0.1 2.7 2 0 0 2 2 2 0 Ribosomal protein S6 adh_short PF00106.20 EFE43349.1 - 1.4e-23 83.6 0.0 1.9e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE43349.1 - 8.3e-11 41.8 0.0 2.2e-10 40.4 0.0 1.6 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE43349.1 - 2e-06 27.7 0.0 3e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFE43349.1 - 4.1e-05 23.6 0.3 0.00035 20.6 0.1 2.4 2 1 0 2 2 2 1 NADH(P)-binding Shikimate_DH PF01488.15 EFE43349.1 - 0.0017 18.4 0.1 0.0053 16.8 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Glyco_transf_4 PF13439.1 EFE43349.1 - 0.0025 17.5 0.1 0.012 15.3 0.1 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Epimerase PF01370.16 EFE43349.1 - 0.0027 17.1 0.0 0.0052 16.2 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 EFE43349.1 - 0.0038 16.3 0.1 0.0071 15.4 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.3 EFE43349.1 - 0.0082 15.9 1.8 0.01 15.5 0.4 1.8 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_7 PF13241.1 EFE43349.1 - 0.023 14.9 0.0 0.042 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 EFE43349.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosomal_L6e PF01159.14 EFE43352.1 - 3.3e-34 117.3 0.0 5.7e-34 116.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e Proteasom_Rpn13 PF04683.8 EFE43353.1 - 6.1e-27 93.5 0.0 1.1e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DUF3306 PF11748.3 EFE43353.1 - 7.9 7.1 12.8 12 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Ion_trans PF00520.26 EFE43354.1 - 1.2e-105 351.1 84.6 3.7e-32 111.2 5.1 5.1 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.27 EFE43354.1 - 0.0015 17.7 0.0 0.0081 15.3 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 EFE43354.1 - 0.037 14.1 0.0 0.15 12.1 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 EFE43354.1 - 0.074 12.9 0.0 0.51 10.3 0.0 2.5 1 0 0 1 1 1 0 EF-hand domain SET PF00856.23 EFE43356.1 - 4.1e-22 79.1 0.1 1.3e-21 77.6 0.1 1.8 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.11 EFE43356.1 - 1.8e-12 47.3 4.4 1.8e-12 47.3 3.0 2.2 3 0 0 3 3 3 1 Pre-SET motif Nop52 PF05997.7 EFE43357.1 - 7.3e-28 97.4 0.0 9.4e-19 67.7 0.0 2.1 2 0 0 2 2 2 2 Nucleolar protein,Nop52 MACPF PF01823.14 EFE43357.1 - 0.036 13.7 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 MAC/Perforin domain ubiquitin PF00240.18 EFE43358.1 - 0.023 14.0 0.0 0.12 11.7 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family ER_lumen_recept PF00810.13 EFE43359.1 - 2.8e-46 157.6 5.3 2.8e-46 157.6 3.7 1.9 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.9 EFE43359.1 - 0.36 10.3 6.5 0.71 9.4 0.1 3.1 3 0 0 3 3 3 0 PQ loop repeat DUF382 PF04037.8 EFE43360.1 - 1.1e-61 206.3 1.2 1.1e-61 206.3 0.9 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.11 EFE43360.1 - 4.6e-21 73.9 6.2 1.1e-20 72.7 4.3 1.7 1 0 0 1 1 1 1 PSP Ribonuclease_3 PF00636.21 EFE43361.1 - 4.5e-15 56.0 0.1 1.3e-13 51.3 0.0 2.8 3 0 0 3 3 3 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EFE43361.1 - 7.4e-12 45.3 0.0 1.9e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.20 EFE43361.1 - 0.19 12.3 0.1 0.19 12.3 0.0 2.4 2 0 0 2 2 2 0 Double-stranded RNA binding motif RTA1 PF04479.8 EFE43362.1 - 6.7e-39 133.7 1.0 9.5e-39 133.1 0.7 1.2 1 0 0 1 1 1 1 RTA1 like protein Fungal_trans_2 PF11951.3 EFE43363.1 - 0.00072 18.2 0.0 0.0012 17.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3115 PF11312.3 EFE43363.1 - 0.053 12.3 0.1 0.076 11.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3115) Ribosomal_S3Ae PF01015.13 EFE43364.1 - 5.1e-77 257.6 7.0 6.2e-77 257.3 4.9 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family GTP_CH_N PF12471.3 EFE43365.1 - 2.2e-71 239.5 0.1 4.6e-57 192.8 0.0 2.2 1 1 1 2 2 2 2 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.15 EFE43365.1 - 2.7e-16 59.2 0.0 6.4e-16 58.0 0.0 1.6 1 0 0 1 1 1 1 GTP cyclohydrolase II UPRTase PF14681.1 EFE43366.1 - 1.1e-65 220.6 0.0 1.4e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EFE43366.1 - 0.00075 19.2 0.0 0.0011 18.7 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 EFE43366.1 - 0.12 12.1 0.5 0.21 11.3 0.4 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) WAPL PF07814.8 EFE43367.1 - 7.6e-29 100.5 6.6 1.2e-28 99.9 4.6 1.2 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin ATP12 PF07542.6 EFE43368.1 - 1.6e-34 118.4 0.2 2.4e-34 117.9 0.2 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Oxysterol_BP PF01237.13 EFE43369.1 - 1.6e-133 444.5 0.0 4.9e-133 443.0 0.0 1.8 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_2 PF12796.2 EFE43369.1 - 1.3e-23 83.1 0.1 5.1e-13 49.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFE43369.1 - 6.9e-20 70.6 0.2 1.3e-11 44.3 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 EFE43369.1 - 5.4e-17 60.6 0.2 3.3e-06 26.6 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 EFE43369.1 - 4.3e-14 51.2 0.0 3.5e-05 23.6 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 EFE43369.1 - 4e-12 46.2 0.1 1.3e-05 25.5 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) PH PF00169.24 EFE43369.1 - 4e-10 39.8 0.1 9.4e-10 38.6 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 EFE43369.1 - 1.3e-08 35.0 1.0 1.3e-08 35.0 0.7 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.1 EFE43369.1 - 3.9e-07 30.0 0.8 1.1e-06 28.6 0.5 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain LLC1 PF14945.1 EFE43369.1 - 0.004 17.4 1.6 0.004 17.4 1.1 3.1 3 0 0 3 3 3 1 Normal lung function maintenance, Low in Lung Cancer 1 protein zf-Mss51 PF13824.1 EFE43370.1 - 1.6e-28 98.3 8.7 4.8e-28 96.7 6.0 1.9 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.13 EFE43370.1 - 0.0031 17.3 2.4 0.0031 17.3 1.7 2.0 2 0 0 2 2 2 1 MYND finger GFA PF04828.9 EFE43370.1 - 0.066 13.1 0.6 0.25 11.2 0.1 2.1 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme GRP PF07172.6 EFE43371.1 - 0.015 15.7 25.0 0.31 11.5 17.3 2.2 1 1 0 1 1 1 0 Glycine rich protein family ADH_zinc_N PF00107.21 EFE43372.1 - 9.1e-30 102.8 0.5 1.5e-29 102.1 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFE43372.1 - 6.7e-10 39.9 0.1 1.7e-09 38.5 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE43372.1 - 5.6e-08 32.5 0.0 1.9e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Pep_deformylase PF01327.16 EFE43372.1 - 0.1 12.0 0.1 0.2 11.0 0.1 1.4 1 0 0 1 1 1 0 Polypeptide deformylase Clr5 PF14420.1 EFE43373.1 - 5.6e-14 51.7 0.8 8.9e-14 51.1 0.6 1.3 1 0 0 1 1 1 1 Clr5 domain SNF2_N PF00176.18 EFE43374.1 - 3.6e-73 245.9 0.9 5.6e-73 245.3 0.6 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE43374.1 - 4.4e-15 55.2 0.0 1.2e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE43374.1 - 3.7e-07 30.1 0.0 1.3e-06 28.3 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EFE43374.1 - 1.1e-05 25.0 0.2 8.9e-05 22.0 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase HSA PF07529.8 EFE43374.1 - 3.9e-05 23.3 5.7 0.00016 21.3 4.0 2.1 1 0 0 1 1 1 1 HSA TM231 PF10149.4 EFE43374.1 - 0.08 11.9 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 231 Membr_traf_MHD PF10540.4 EFE43375.1 - 5.6e-26 90.9 0.0 1.7e-25 89.4 0.0 1.9 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.25 EFE43375.1 - 1e-13 50.9 0.0 2.3e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.6 EFE43375.1 - 2.3e-05 22.9 0.1 3.8e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF810) Ribonuc_L-PSP PF01042.16 EFE43376.1 - 5.7e-37 126.1 0.0 6.3e-37 126.0 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP NmrA PF05368.8 EFE43377.1 - 2.2e-12 46.7 0.0 2.5e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 EFE43377.1 - 0.0001 21.8 0.0 0.14 11.6 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFE43377.1 - 0.0018 18.3 0.0 0.0027 17.7 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Lumazine_bd_2 PF12893.2 EFE43378.1 - 5.5e-25 88.1 0.0 6.5e-25 87.9 0.0 1.0 1 0 0 1 1 1 1 Putative lumazine-binding Lumazine_bd PF12870.2 EFE43378.1 - 0.00016 21.6 0.0 0.00081 19.4 0.0 1.9 1 1 0 1 1 1 1 Lumazine-binding domain Catalase PF00199.14 EFE43379.1 - 2.4e-133 444.5 0.0 3.3e-133 444.1 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EFE43379.1 - 2.8e-07 30.3 0.0 8.9e-07 28.6 0.0 1.9 2 0 0 2 2 2 1 Catalase-related immune-responsive adh_short PF00106.20 EFE43380.1 - 8.5e-21 74.5 0.1 1.4e-20 73.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE43380.1 - 2.5e-11 43.5 0.2 4.9e-11 42.6 0.1 1.5 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFE43380.1 - 2.4e-10 40.5 0.0 3e-09 36.9 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EFE43380.1 - 0.0025 17.2 0.0 0.022 14.1 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFE43380.1 - 0.0087 14.9 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF4332 PF14229.1 EFE43380.1 - 0.019 14.9 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) NAD_binding_10 PF13460.1 EFE43380.1 - 0.095 12.6 0.4 7.8 6.4 0.2 2.4 2 1 0 2 2 2 0 NADH(P)-binding Methyltransf_33 PF10017.4 EFE43381.1 - 1.1e-28 99.7 0.0 2.6e-28 98.4 0.0 1.6 2 0 0 2 2 2 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_25 PF13649.1 EFE43381.1 - 0.055 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain FAD_binding_4 PF01565.18 EFE43382.1 - 2.8e-22 78.6 0.9 5.5e-22 77.7 0.6 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE43382.1 - 1e-08 34.9 0.4 2.4e-08 33.7 0.3 1.7 1 0 0 1 1 1 1 Berberine and berberine like Trp_DMAT PF11991.3 EFE43383.1 - 7.7e-122 406.9 0.0 8.9e-122 406.7 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase HD PF01966.17 EFE43386.1 - 0.0092 15.9 0.1 0.02 14.8 0.1 1.5 1 1 0 1 1 1 1 HD domain Glyco_hydro_42M PF08532.5 EFE43387.1 - 0.024 13.7 0.0 2.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase trimerisation domain DUF4350 PF14258.1 EFE43387.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) Pribosyltran PF00156.22 EFE43388.1 - 8.2e-11 41.7 0.0 1.4e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MIF4G PF02854.14 EFE43389.1 - 5.1e-52 176.3 0.0 7.9e-52 175.6 0.0 1.3 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 EFE43389.1 - 2.2e-23 81.9 1.3 6.1e-23 80.5 0.9 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 BAF1_ABF1 PF04684.8 EFE43389.1 - 0.1 11.4 26.4 0.2 10.4 18.3 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Methyltransf_16 PF10294.4 EFE43390.1 - 2.5e-09 36.8 0.2 0.00013 21.4 0.0 2.4 2 1 0 2 2 2 2 Putative methyltransferase LVIVD PF08309.6 EFE43391.1 - 1.7e-06 26.9 0.4 0.022 13.7 0.0 4.3 4 0 0 4 4 4 2 LVIVD repeat Beta_propel PF09826.4 EFE43391.1 - 0.0021 16.4 0.1 1.6 6.9 0.0 2.5 1 1 1 3 3 3 2 Beta propeller domain AMP-binding PF00501.23 EFE43393.1 - 3.9e-81 272.5 0.0 5.3e-81 272.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE43393.1 - 0.011 16.7 0.0 0.023 15.6 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain NDT80_PhoG PF05224.7 EFE43396.1 - 2.2e-41 141.9 0.1 3.3e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Cyclin_N PF00134.18 EFE43397.1 - 0.00011 21.7 0.0 0.00032 20.2 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain ABC_tran PF00005.22 EFE43398.1 - 3.6e-48 163.3 0.0 1.3e-23 83.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFE43398.1 - 6.5e-21 75.5 1.0 0.0005 20.1 0.0 4.2 3 1 0 4 4 4 4 AAA domain ABC_tran_2 PF12848.2 EFE43398.1 - 2.3e-20 72.1 3.1 2.3e-20 72.1 2.2 2.5 3 0 0 3 3 2 1 ABC transporter SMC_N PF02463.14 EFE43398.1 - 2.8e-11 43.0 0.5 0.0012 18.1 0.1 4.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EFE43398.1 - 1.4e-09 37.2 0.6 0.0005 19.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EFE43398.1 - 1.4e-08 35.2 3.8 0.035 14.4 0.1 3.6 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 EFE43398.1 - 7.6e-07 28.4 0.0 0.0018 17.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFE43398.1 - 8.4e-07 29.8 0.0 0.0071 17.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EFE43398.1 - 1.8e-06 28.3 0.1 0.032 14.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.18 EFE43398.1 - 6.6e-06 26.0 0.0 0.074 13.0 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 EFE43398.1 - 1.6e-05 25.3 0.0 0.05 14.1 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_22 PF13401.1 EFE43398.1 - 2.1e-05 24.6 0.0 0.27 11.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EFE43398.1 - 4e-05 23.3 0.2 0.37 10.4 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.1 EFE43398.1 - 4.4e-05 22.7 0.0 0.099 11.6 0.0 3.1 3 1 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.1 EFE43398.1 - 9.2e-05 22.3 1.3 0.22 11.3 0.0 3.2 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.1 EFE43398.1 - 0.0001 22.3 0.3 0.36 10.7 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.18 EFE43398.1 - 0.00017 21.4 2.1 0.33 10.7 0.0 3.5 3 1 1 4 4 3 2 Dynamin family AAA PF00004.24 EFE43398.1 - 0.00019 21.6 0.0 0.83 9.8 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 EFE43398.1 - 0.00028 21.0 0.7 1.2 9.3 0.0 3.1 3 0 0 3 3 2 2 RNA helicase Arch_ATPase PF01637.13 EFE43398.1 - 0.00034 20.3 1.1 0.84 9.2 0.0 3.5 3 1 0 4 4 4 1 Archaeal ATPase AAA_5 PF07728.9 EFE43398.1 - 0.00036 20.2 0.1 1 9.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 EFE43398.1 - 0.0004 20.3 0.0 0.27 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 EFE43398.1 - 0.00094 18.1 0.1 0.37 9.5 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain AAA_14 PF13173.1 EFE43398.1 - 0.0014 18.5 0.0 2.7 7.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFE43398.1 - 0.0015 17.9 0.0 0.65 9.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.1 EFE43398.1 - 0.002 17.9 0.6 0.42 10.5 0.1 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 EFE43398.1 - 0.0038 16.7 1.0 1.9 7.8 0.1 2.7 2 0 0 2 2 2 1 AAA-like domain ATP-synt_ab PF00006.20 EFE43398.1 - 0.004 16.6 0.0 0.045 13.2 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.8 EFE43398.1 - 0.0047 15.8 0.0 0.41 9.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) MobB PF03205.9 EFE43398.1 - 0.0054 16.4 0.7 0.15 11.7 0.1 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B DUF2813 PF11398.3 EFE43398.1 - 0.0094 15.0 1.2 1.3 7.9 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF2813) NTPase_1 PF03266.10 EFE43398.1 - 0.017 14.8 0.0 3 7.5 0.0 2.7 2 0 0 2 2 2 0 NTPase VirE PF05272.6 EFE43398.1 - 0.02 14.3 0.3 1.5 8.2 0.0 3.0 3 0 0 3 3 3 0 Virulence-associated protein E DAP3 PF10236.4 EFE43398.1 - 0.027 13.4 1.2 3.8 6.3 0.1 2.7 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 PduV-EutP PF10662.4 EFE43398.1 - 0.033 13.6 2.0 1.8 8.0 0.0 3.1 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.17 EFE43398.1 - 0.052 12.9 0.0 5.7 6.3 0.0 2.6 2 0 0 2 2 2 0 Ras family ABC_ATPase PF09818.4 EFE43398.1 - 0.055 12.0 0.2 19 3.6 0.0 3.4 3 1 0 3 3 3 0 Predicted ATPase of the ABC class MCM PF00493.18 EFE43398.1 - 0.057 12.2 1.7 3.6 6.3 0.0 2.6 3 0 0 3 3 3 0 MCM2/3/5 family AAA_13 PF13166.1 EFE43398.1 - 0.93 7.8 6.8 10 4.4 0.0 3.6 4 0 0 4 4 4 0 AAA domain p450 PF00067.17 EFE43399.1 - 3e-27 95.2 0.0 4e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 SKG6 PF08693.5 EFE43399.1 - 0.065 12.5 0.7 0.13 11.6 0.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF4267 PF14087.1 EFE43401.1 - 2.9e-25 88.0 3.1 3.3e-25 87.8 2.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) MFS_1 PF07690.11 EFE43402.1 - 1.3e-37 129.3 53.3 1.3e-36 126.0 36.9 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE43402.1 - 2.1e-16 59.5 11.1 2.1e-16 59.5 7.7 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFE43402.1 - 2.2e-14 52.6 16.0 3.3e-14 52.0 11.1 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) HPP PF04982.8 EFE43403.1 - 6.4e-37 126.0 7.5 6.4e-37 126.0 5.2 1.4 2 0 0 2 2 2 1 HPP family DUF599 PF04654.7 EFE43403.1 - 0.018 14.1 2.2 0.91 8.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF599 DUF3377 PF11857.3 EFE43403.1 - 0.075 12.6 0.5 0.26 10.9 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Yip1 PF04893.12 EFE43403.1 - 0.18 11.2 11.4 4.7 6.6 3.8 2.7 1 1 1 2 2 2 0 Yip1 domain ABC_cobalt PF09819.4 EFE43403.1 - 0.26 11.2 4.6 0.07 13.0 0.6 1.8 2 0 0 2 2 2 0 ABC-type cobalt transport system, permease component GFO_IDH_MocA PF01408.17 EFE43406.1 - 1.3e-19 70.8 0.3 5.3e-13 49.5 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EFE43406.1 - 6.4e-13 48.4 0.0 1.1e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.11 EFE43406.1 - 0.0011 19.2 0.0 0.0027 18.0 0.0 1.7 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.15 EFE43406.1 - 0.0083 16.0 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus IF-2B PF01008.12 EFE43406.1 - 0.033 13.1 0.0 0.075 12.0 0.0 1.5 1 0 0 1 1 1 0 Initiation factor 2 subunit family F420_oxidored PF03807.12 EFE43406.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ATP-grasp_3 PF02655.9 EFE43407.1 - 4.6e-10 39.5 0.0 7.5e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 EFE43407.1 - 6.2e-10 39.1 0.0 1.5e-09 37.9 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EFE43407.1 - 0.002 16.9 0.0 0.013 14.2 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon MARVEL PF01284.18 EFE43408.1 - 1e-05 25.4 4.5 1.9e-05 24.5 3.1 1.4 1 1 0 1 1 1 1 Membrane-associating domain Choline_transpo PF04515.7 EFE43408.1 - 0.0033 16.2 0.5 0.0069 15.1 0.3 1.6 1 1 0 1 1 1 1 Plasma-membrane choline transporter SecG PF03840.9 EFE43408.1 - 0.0063 16.2 0.5 1.3 8.8 0.0 2.9 3 0 0 3 3 3 1 Preprotein translocase SecG subunit DUF3245 PF11595.3 EFE43408.1 - 0.17 12.1 2.3 1.7 8.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) DUF3099 PF11298.3 EFE43408.1 - 0.7 9.6 2.5 1.8 8.3 1.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) RRM_1 PF00076.17 EFE43411.1 - 2.1e-23 81.7 0.5 5.4e-06 25.9 0.0 5.2 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE43411.1 - 8.1e-16 57.7 0.0 5.4e-05 23.0 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE43411.1 - 7.3e-08 32.1 0.0 0.0031 17.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) API5 PF05918.6 EFE43411.1 - 0.083 11.3 5.6 0.12 10.8 3.9 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) ArfGap PF01412.13 EFE43412.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf GTP_EFTU PF00009.22 EFE43413.1 - 5.7e-54 182.4 0.0 9.8e-54 181.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 EFE43413.1 - 6.3e-25 86.8 0.0 1.7e-24 85.4 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 EFE43413.1 - 2.3e-17 62.6 0.1 1.3e-08 34.5 0.0 2.4 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFE43413.1 - 4.2e-05 23.5 0.0 0.0001 22.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.13 EFE43413.1 - 0.03 13.8 0.2 1.4 8.5 0.0 2.7 3 0 0 3 3 3 0 Elongation factor G, domain IV MMR_HSR1 PF01926.18 EFE43413.1 - 0.07 13.0 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase Vps5 PF09325.5 EFE43414.1 - 1.6e-13 50.4 3.0 3e-13 49.5 2.1 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 EFE43414.1 - 1.8e-08 34.1 0.0 3.9e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 PX domain GFA PF04828.9 EFE43415.1 - 4.3e-19 68.2 0.0 5.3e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme APH PF01636.18 EFE43417.1 - 5.6e-12 45.9 0.0 7.9e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE43417.1 - 0.0044 16.6 0.0 0.0067 16.0 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Tho2 PF11262.3 EFE43418.1 - 9.1e-93 310.5 0.0 1.4e-92 309.9 0.0 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 EFE43418.1 - 2e-29 101.2 0.0 4.9e-29 99.9 0.0 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Macoilin PF09726.4 EFE43419.1 - 3.8 5.6 7.8 3.9 5.6 5.4 1.1 1 0 0 1 1 1 0 Transmembrane protein MFS_1 PF07690.11 EFE43420.1 - 2.3e-22 79.1 21.9 3.8e-22 78.4 14.8 1.6 3 0 0 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE43420.1 - 1.8e-10 40.0 14.1 2.6e-10 39.4 9.8 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MASE2 PF05230.6 EFE43420.1 - 0.043 13.7 0.4 0.14 12.1 0.3 1.9 1 0 0 1 1 1 0 MASE2 domain DUF4231 PF14015.1 EFE43420.1 - 0.2 11.6 2.0 0.4 10.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Abhydrolase_1 PF00561.15 EFE43422.1 - 1.3e-42 145.9 0.0 8.5e-42 143.2 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFE43422.1 - 6.4e-13 49.1 0.6 3.9e-12 46.5 0.4 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE43422.1 - 0.00037 20.2 0.1 0.005 16.5 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 EFE43422.1 - 0.019 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein DUF2424 PF10340.4 EFE43422.1 - 0.25 9.9 0.0 0.39 9.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) DUF706 PF05153.10 EFE43424.1 - 2.7e-119 397.1 1.2 3.4e-119 396.7 0.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF706) HD PF01966.17 EFE43424.1 - 0.085 12.8 0.9 0.69 9.9 0.0 2.5 3 0 0 3 3 3 0 HD domain Alpha-E PF04168.7 EFE43424.1 - 0.095 12.0 0.2 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. AIPR PF10592.4 EFE43424.1 - 0.19 11.0 1.8 0.64 9.2 0.6 2.0 2 1 0 2 2 2 0 AIPR protein Exo_endo_phos PF03372.18 EFE43425.1 - 7.4e-17 62.0 1.3 9.9e-17 61.6 0.9 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2786 PF10979.3 EFE43426.1 - 1.1e-13 50.5 1.6 1.1e-13 50.5 1.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) RTC PF01137.16 EFE43427.1 - 1.7e-33 115.3 0.0 1e-17 63.7 0.1 3.6 2 1 1 3 3 3 3 RNA 3'-terminal phosphate cyclase 7tm_1 PF00001.16 EFE43429.1 - 0.019 14.1 0.3 0.022 13.9 0.2 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TSC21 PF15217.1 EFE43430.1 - 0.039 13.6 0.1 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 TSC21 family SH3_9 PF14604.1 EFE43431.1 - 1.2e-13 50.4 0.1 2.6e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFE43431.1 - 1.2e-12 47.0 0.1 2.3e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain BAR PF03114.13 EFE43431.1 - 1.6e-12 47.4 0.1 2.3e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.12 EFE43431.1 - 2.2e-10 39.8 0.1 4.7e-10 38.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF2439 PF10382.4 EFE43433.1 - 3.1e-26 91.3 0.0 6e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DUF4023 PF13215.1 EFE43433.1 - 0.038 13.7 0.6 0.12 12.1 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) Methyltransf_23 PF13489.1 EFE43434.1 - 3.9e-16 59.1 0.0 6.3e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE43434.1 - 2.2e-06 28.0 0.0 8.8e-06 26.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE43434.1 - 6.6e-06 26.5 0.0 4.7e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE43434.1 - 1.1e-05 25.0 0.0 0.00017 21.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE43434.1 - 0.00017 22.1 0.0 0.00028 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Mcp5_PH PF12814.2 EFE43435.1 - 2.2e-42 143.8 0.1 4.5e-42 142.8 0.1 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology zf-C3HC4_2 PF13923.1 EFE43436.1 - 7.8e-08 32.2 12.0 1.4e-07 31.4 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.19 EFE43436.1 - 9.5e-08 31.5 2.8 1.6e-07 30.7 2.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.1 EFE43436.1 - 1.6e-07 30.8 6.7 2.8e-07 30.1 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE43436.1 - 2.7e-06 26.9 10.5 4.6e-06 26.2 7.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFE43436.1 - 1.3e-05 24.7 12.2 2.2e-05 23.9 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE43436.1 - 1.7e-05 24.5 9.7 3.1e-05 23.7 6.7 1.4 1 0 0 1 1 1 1 Ring finger domain Cript PF10235.4 EFE43436.1 - 0.018 15.3 1.7 0.018 15.3 1.2 2.2 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT zf-C3HC4_4 PF15227.1 EFE43436.1 - 0.026 14.3 9.0 0.057 13.3 6.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFE43436.1 - 0.11 12.2 7.8 0.25 11.0 5.4 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.3 EFE43436.1 - 0.43 10.1 4.1 0.76 9.3 2.8 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.2 EFE43436.1 - 7.1 6.8 9.0 19 5.4 6.2 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger ERGIC_N PF13850.1 EFE43437.1 - 8.1 6.4 6.1 1 9.3 0.8 2.0 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF3431 PF11913.3 EFE43438.1 - 2.3e-75 252.8 0.0 5.7e-75 251.6 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) Myb_DNA-bind_6 PF13921.1 EFE43439.1 - 9.8e-06 25.5 0.0 2.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFE43439.1 - 0.002 18.1 0.4 0.005 16.8 0.3 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Pkinase PF00069.20 EFE43440.1 - 7e-57 192.5 0.0 2e-56 191.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43440.1 - 3.3e-26 91.9 0.0 1.4e-24 86.5 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 EFE43440.1 - 2.8e-11 43.3 0.0 7e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 FHA domain APH PF01636.18 EFE43440.1 - 0.0022 17.7 0.5 0.007 16.1 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family TRAUB PF08164.7 EFE43440.1 - 0.024 14.7 0.6 0.056 13.5 0.4 1.6 1 0 0 1 1 1 0 Apoptosis-antagonizing transcription factor, C-terminal P2X_receptor PF00864.14 EFE43441.1 - 0.024 13.3 0.2 0.036 12.7 0.1 1.1 1 0 0 1 1 1 0 ATP P2X receptor Ank_5 PF13857.1 EFE43442.1 - 0.00012 22.2 0.0 0.00026 21.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 EFE43442.1 - 0.00029 20.4 0.0 0.00068 19.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 EFE43442.1 - 0.00043 20.2 0.0 0.0014 18.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.1 EFE43442.1 - 0.0029 18.0 0.0 0.0065 16.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFE43442.1 - 0.0088 16.3 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) ABC_membrane PF00664.18 EFE43443.1 - 4e-83 279.0 31.2 8e-46 156.6 7.5 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE43443.1 - 9.4e-45 152.2 0.0 2e-23 83.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE43443.1 - 1.6e-07 30.7 1.8 0.033 13.4 0.0 4.1 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EFE43443.1 - 4.7e-06 25.8 0.6 0.0019 17.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EFE43443.1 - 2.1e-05 24.4 1.0 0.21 11.5 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_25 PF13481.1 EFE43443.1 - 2.3e-05 23.9 0.2 0.18 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFE43443.1 - 5.7e-05 23.1 2.5 0.18 11.8 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 EFE43443.1 - 0.00079 19.9 0.6 1.1 9.8 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_29 PF13555.1 EFE43443.1 - 0.00083 18.8 0.4 0.63 9.6 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain Dynamin_N PF00350.18 EFE43443.1 - 0.0015 18.4 0.8 0.13 12.1 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.1 EFE43443.1 - 0.0021 17.6 0.1 1.2 8.6 0.0 3.1 3 1 0 3 3 2 1 AAA domain DUF87 PF01935.12 EFE43443.1 - 0.0083 15.9 2.5 1.2 8.8 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_23 PF13476.1 EFE43443.1 - 0.013 15.7 0.3 0.53 10.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EFE43443.1 - 0.016 15.3 0.0 1.4 9.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase FtsK_SpoIIIE PF01580.13 EFE43443.1 - 0.027 13.9 0.1 2.9 7.3 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.1 EFE43443.1 - 0.04 14.0 1.5 4.2 7.5 0.0 3.1 2 1 0 2 2 2 0 AAA domain AAA_21 PF13304.1 EFE43443.1 - 0.051 13.5 0.3 2.1 8.2 0.0 3.0 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.7 EFE43443.1 - 0.057 12.5 0.1 6.7 5.7 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin GTP_EFTU PF00009.22 EFE43443.1 - 0.073 12.4 0.0 9.3 5.6 0.0 2.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 EFE43443.1 - 0.11 11.8 2.6 10 5.4 0.2 2.8 2 1 1 3 3 3 0 AAA-like domain MobB PF03205.9 EFE43443.1 - 0.37 10.4 1.7 14 5.3 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Ycf1 PF05758.7 EFE43445.1 - 0.00017 19.5 2.1 0.00019 19.3 1.5 1.0 1 0 0 1 1 1 1 Ycf1 SID-1_RNA_chan PF13965.1 EFE43445.1 - 0.031 12.4 0.0 0.032 12.4 0.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF1673 PF07895.6 EFE43445.1 - 0.044 13.3 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF3260 PF11658.3 EFE43445.1 - 0.045 11.8 0.1 0.052 11.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) RR_TM4-6 PF06459.7 EFE43445.1 - 0.052 13.4 9.9 0.069 13.0 6.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF106 PF01956.11 EFE43445.1 - 0.069 12.6 2.8 0.11 12.0 1.9 1.5 1 0 0 1 1 1 0 Integral membrane protein DUF106 Neur_chan_memb PF02932.11 EFE43445.1 - 0.076 12.8 0.2 0.076 12.8 0.1 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region FHIPEP PF00771.15 EFE43445.1 - 0.1 10.9 0.0 0.12 10.6 0.0 1.2 1 0 0 1 1 1 0 FHIPEP family YfhO PF09586.5 EFE43445.1 - 0.13 10.2 0.0 0.16 10.0 0.0 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO AIF_C PF14721.1 EFE43445.1 - 0.73 10.0 5.9 0.98 9.6 4.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF1980 PF09323.5 EFE43445.1 - 0.99 9.1 5.2 1.7 8.3 3.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) RNase_H2-Ydr279 PF09468.5 EFE43445.1 - 2 7.5 14.0 2.7 7.0 9.7 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Mem_trans PF03547.13 EFE43445.1 - 2.8 6.1 4.5 4.5 5.4 3.1 1.4 1 1 0 1 1 1 0 Membrane transport protein DUF4094 PF13334.1 EFE43445.1 - 2.8 8.4 8.1 2.6 8.5 3.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) MIP-T3 PF10243.4 EFE43445.1 - 3.1 6.1 27.9 3.6 5.9 19.3 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Serinc PF03348.10 EFE43445.1 - 4.4 5.9 6.6 7.9 5.0 4.6 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) YqfQ PF14181.1 EFE43445.1 - 4.6 7.2 17.0 6 6.8 11.8 1.1 1 0 0 1 1 1 0 YqfQ-like protein Med19 PF10278.4 EFE43445.1 - 5.6 6.6 25.0 11 5.7 17.3 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Adeno_VII PF03228.9 EFE43445.1 - 6.8 7.3 13.8 9.2 6.8 9.5 1.1 1 0 0 1 1 1 0 Adenoviral core protein VII DUF2841 PF11001.3 EFE43448.1 - 5.4e-49 165.2 0.1 9.4e-49 164.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Zip PF02535.17 EFE43449.1 - 4.8e-46 157.2 5.2 5.9e-46 156.9 3.6 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter 7TM_transglut PF14402.1 EFE43449.1 - 0.0031 16.4 0.1 0.0059 15.5 0.0 1.4 1 0 0 1 1 1 1 7 transmembrane helices usually fused to an inactive transglutaminase DUF805 PF05656.9 EFE43449.1 - 2.1 8.2 7.0 1.1 9.0 1.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF805) SAC3_GANP PF03399.11 EFE43450.1 - 2.5e-53 180.6 2.2 3.4e-53 180.2 1.6 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family CN_hydrolase PF00795.17 EFE43452.1 - 2.5e-06 26.9 0.0 0.0037 16.6 0.0 3.0 2 1 1 3 3 3 2 Carbon-nitrogen hydrolase HLH PF00010.21 EFE43453.1 - 5.2e-12 45.2 1.2 1e-11 44.3 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2681 PF10883.3 EFE43453.1 - 0.65 10.2 6.5 4.2 7.6 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Filo_VP35 PF02097.10 EFE43453.1 - 2.3 7.3 7.9 5.7 6.0 1.5 2.4 1 1 0 2 2 2 0 Filoviridae VP35 FAD_binding_4 PF01565.18 EFE43454.1 - 1.4e-18 66.6 4.0 2.7e-18 65.7 2.8 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE43454.1 - 0.00098 18.9 0.0 0.0025 17.6 0.0 1.7 2 0 0 2 2 2 1 Berberine and berberine like Transgly_assoc PF04226.8 EFE43454.1 - 0.0099 15.9 4.3 0.022 14.8 3.0 1.6 1 0 0 1 1 1 1 Transglycosylase associated protein PRANC PF09372.5 EFE43455.1 - 0.023 14.6 0.1 0.042 13.8 0.1 1.4 1 0 0 1 1 1 0 PRANC domain F-box-like PF12937.2 EFE43455.1 - 0.093 12.4 0.1 0.51 10.1 0.0 2.3 2 0 0 2 2 2 0 F-box-like Orn_Arg_deC_N PF02784.11 EFE43457.1 - 2e-42 145.1 0.0 2.7e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 EFE43457.1 - 3e-21 75.3 0.0 1.7e-17 63.1 0.0 2.3 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase, C-terminal sheet domain SnoaL_4 PF13577.1 EFE43458.1 - 3.8e-15 55.9 0.0 4.5e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain AMP-binding PF00501.23 EFE43459.1 - 2.5e-157 523.5 0.1 4.6e-80 269.0 0.1 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 EFE43459.1 - 2.3e-54 184.3 0.0 1.1e-32 113.0 0.0 2.4 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.20 EFE43459.1 - 1.9e-21 76.0 0.1 1.2e-10 41.4 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE43459.1 - 3.6e-12 47.0 0.3 8.7e-05 23.4 0.0 3.5 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain AATase PF07247.7 EFE43459.1 - 0.012 14.1 0.0 1.2 7.5 0.0 2.8 3 0 0 3 3 3 0 Alcohol acetyltransferase p450 PF00067.17 EFE43460.1 - 5.9e-46 156.9 0.0 7.7e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SnoaL_3 PF13474.1 EFE43461.1 - 2.7e-07 30.6 0.4 3e-07 30.5 0.3 1.3 1 1 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.5 EFE43461.1 - 0.017 15.0 0.3 0.049 13.5 0.1 1.7 2 0 0 2 2 2 0 Calcium/calmodulin dependent protein kinase II Association Sulfotransfer_3 PF13469.1 EFE43462.1 - 0.011 16.7 0.2 0.014 16.2 0.2 1.3 1 0 0 1 1 1 0 Sulfotransferase family Methyltransf_2 PF00891.13 EFE43463.1 - 2.8e-36 124.9 0.0 4.3e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 EFE43463.1 - 0.0033 17.9 0.1 0.013 16.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_PK PF05891.7 EFE43463.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.7 EFE43463.1 - 0.024 15.0 0.0 0.096 13.1 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain AMP-binding PF00501.23 EFE43464.1 - 2.3e-79 266.7 0.0 3.5e-79 266.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 EFE43464.1 - 1.3e-44 152.2 0.0 2.3e-27 95.6 0.0 2.6 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.20 EFE43464.1 - 4.2e-21 74.9 3.2 6.8e-06 26.2 0.1 4.2 4 0 0 4 4 4 3 Phosphopantetheine attachment site HxxPF_rpt PF13745.1 EFE43464.1 - 0.00025 21.3 0.0 0.0061 16.8 0.0 2.5 2 0 0 2 2 2 1 HxxPF-repeated domain WES_acyltransf PF03007.11 EFE43464.1 - 0.002 17.7 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain MFS_1 PF07690.11 EFE43466.1 - 2.4e-29 102.1 15.2 3e-25 88.6 5.3 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE43466.1 - 4.1e-11 42.1 9.0 7.9e-11 41.1 6.2 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 EFE43466.1 - 2.5e-08 32.7 3.4 2.5e-08 32.7 1.4 1.6 1 1 0 1 1 1 1 MFS/sugar transport protein NfeD PF01957.13 EFE43466.1 - 0.0011 19.1 5.5 0.1 12.7 0.1 3.3 3 0 0 3 3 3 2 NfeD-like C-terminal, partner-binding DUF4131 PF13567.1 EFE43466.1 - 0.0083 15.5 4.7 1.6 8.1 0.0 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4131) CLN3 PF02487.12 EFE43466.1 - 0.42 9.3 9.8 0.086 11.6 0.6 3.1 1 1 3 4 4 4 0 CLN3 protein Claudin_2 PF13903.1 EFE43466.1 - 2.8 7.6 11.0 12 5.5 0.3 3.4 2 2 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction PAP2 PF01569.16 EFE43466.1 - 4.5 6.9 9.7 6.9 6.3 0.2 3.2 3 1 0 3 3 3 0 PAP2 superfamily adh_short PF00106.20 EFE43467.1 - 1.3e-25 90.2 0.0 2.5e-25 89.3 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE43467.1 - 4e-20 72.6 0.0 1.4e-19 70.8 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE43467.1 - 0.004 16.8 0.0 0.011 15.4 0.0 1.7 1 1 0 1 1 1 1 KR domain HAD PF12710.2 EFE43467.1 - 0.013 15.6 0.0 0.062 13.4 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase RRM_6 PF14259.1 EFE43468.1 - 2.7e-10 40.0 0.0 2e-09 37.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFE43468.1 - 1.1e-08 34.5 0.1 9.2e-06 25.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE43468.1 - 5.9e-07 29.2 0.0 1.4e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE43468.1 - 7.3e-05 22.4 0.0 0.00072 19.2 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.19 EFE43468.1 - 0.00016 21.2 1.2 0.00028 20.5 0.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PWI PF01480.12 EFE43468.1 - 0.00018 21.5 0.1 0.00038 20.5 0.1 1.5 1 0 0 1 1 1 1 PWI domain RRM_3 PF08777.6 EFE43468.1 - 1.6 8.6 9.3 1.4 8.8 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif GTP_EFTU PF00009.22 EFE43469.1 - 1.1e-55 188.0 0.1 1.6e-55 187.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EFE43469.1 - 9e-35 118.8 0.0 3.3e-34 117.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 EFE43469.1 - 5.9e-21 74.1 0.0 1.6e-20 72.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFE43469.1 - 6.2e-13 48.6 0.0 5e-12 45.7 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EFE43469.1 - 5.4e-12 45.3 0.0 1.4e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 EFE43469.1 - 5e-05 23.2 0.1 0.00013 21.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Solute_trans_a PF03619.11 EFE43471.1 - 9.4e-64 215.3 0.4 1.2e-63 214.9 0.3 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha GSK-3_bind PF05350.7 EFE43472.1 - 0.26 10.6 3.6 7.1 6.0 0.1 2.4 2 0 0 2 2 2 0 Glycogen synthase kinase-3 binding Beta_elim_lyase PF01212.16 EFE43473.1 - 6.5e-84 281.4 0.0 7.9e-84 281.2 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EFE43473.1 - 4.2e-09 35.8 0.0 7.7e-09 34.9 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EFE43473.1 - 2.7e-06 26.6 0.0 0.046 12.7 0.0 2.1 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EFE43473.1 - 1.2e-05 24.2 0.0 4.4e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EFE43473.1 - 4.4e-05 21.9 0.0 0.00025 19.4 0.0 2.0 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.15 EFE43473.1 - 0.064 11.7 0.0 0.093 11.2 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Dynactin PF12455.3 EFE43474.1 - 1.1e-95 319.7 1.0 1.1e-95 319.7 0.7 3.5 3 1 1 4 4 4 1 Dynein associated protein CAP_GLY PF01302.20 EFE43474.1 - 2.9e-19 68.5 0.1 4.9e-19 67.7 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain HAD_2 PF13419.1 EFE43476.1 - 3.7e-19 69.6 0.8 3.2e-18 66.5 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE43476.1 - 0.026 14.2 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 HAD-hyrolase-like CD99L2 PF12301.3 EFE43477.1 - 0.31 10.7 8.6 1.2 8.8 3.5 2.1 2 0 0 2 2 2 0 CD99 antigen like protein 2 KH_1 PF00013.24 EFE43478.1 - 9.4e-23 79.6 1.2 1.6e-06 27.6 0.1 7.0 8 0 0 8 8 8 4 KH domain KH_3 PF13014.1 EFE43478.1 - 9.2e-19 66.6 4.2 0.00069 19.2 0.0 6.7 7 0 0 7 7 7 3 KH domain DUF2706 PF10913.3 EFE43478.1 - 0.035 13.6 0.0 0.083 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) PAT1 PF09770.4 EFE43478.1 - 0.065 11.4 29.4 0.09 11.0 20.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 EFE43478.1 - 0.57 10.0 11.4 0.9 9.3 7.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF605 PF04652.11 EFE43478.1 - 4.4 6.6 22.9 8.8 5.6 15.9 1.4 1 0 0 1 1 1 0 Vta1 like Chitin_synth_2 PF03142.10 EFE43479.1 - 1.4e-254 845.3 0.7 2.1e-254 844.8 0.5 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.16 EFE43479.1 - 1e-179 598.9 0.0 1.3e-179 598.5 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.23 EFE43479.1 - 2.5e-18 65.6 0.0 1.4e-12 47.2 0.0 3.4 1 1 1 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.6 EFE43479.1 - 8.4e-17 60.6 2.0 2.8e-16 59.0 1.1 2.2 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.1 EFE43479.1 - 2e-15 57.0 5.5 2e-15 57.0 3.8 1.8 2 0 0 2 2 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFE43479.1 - 1.5e-14 54.3 0.1 2e-11 44.1 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 EFE43479.1 - 5.6e-05 22.8 0.0 0.0047 16.6 0.0 3.0 3 0 0 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 EFE43479.1 - 0.00074 18.8 0.3 0.0053 16.0 0.2 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 21 AAA_16 PF13191.1 EFE43479.1 - 0.0039 17.1 0.1 0.011 15.7 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 EFE43479.1 - 0.02 14.0 0.0 0.41 9.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFE43479.1 - 0.11 12.6 0.1 0.38 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Chitin_synth_2 PF03142.10 EFE43480.1 - 2.7e-229 761.9 0.0 3.8e-229 761.4 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.16 EFE43480.1 - 1.2e-69 235.1 0.0 6.4e-69 232.7 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.23 EFE43480.1 - 3.1e-22 78.1 0.0 8.4e-12 44.7 0.0 2.5 1 1 1 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.6 EFE43480.1 - 5.8e-16 57.9 0.9 1.5e-15 56.7 0.5 1.8 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.1 EFE43480.1 - 1.2e-15 57.7 4.3 1.2e-15 57.7 3.0 2.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFE43480.1 - 6.7e-15 55.5 0.0 8.3e-12 45.3 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EFE43480.1 - 1.9e-06 27.2 0.0 5.3e-05 22.5 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EFE43480.1 - 0.00094 18.9 0.0 0.088 12.4 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 TPP_enzyme_N PF02776.13 EFE43481.1 - 6.4e-33 113.6 0.0 2.8e-32 111.5 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EFE43481.1 - 1.2e-20 73.5 0.0 2.3e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EFE43481.1 - 6e-20 71.4 0.0 2.1e-19 69.6 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain NTP_transf_3 PF12804.2 EFE43481.1 - 0.2 11.7 1.1 1.8 8.6 0.3 2.7 2 1 0 2 2 2 0 MobA-like NTP transferase domain TatD_DNase PF01026.16 EFE43482.1 - 1.1e-37 129.5 0.0 1.9e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 TatD related DNase BCDHK_Adom3 PF10436.4 EFE43484.1 - 1.1e-43 148.6 0.0 1.5e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EFE43484.1 - 1.1e-14 54.0 0.0 7e-14 51.4 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EFE43484.1 - 0.0055 16.4 0.0 0.021 14.5 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain DUF3397 PF11877.3 EFE43485.1 - 0.013 15.5 2.2 0.013 15.5 1.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3397) DUF805 PF05656.9 EFE43485.1 - 1.4 8.7 10.2 1.6 8.6 1.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF805) DUF2157 PF09925.4 EFE43485.1 - 3.9 7.0 9.8 0.056 13.0 0.8 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Lactamase_B_2 PF12706.2 EFE43486.1 - 2e-05 24.2 0.0 2.6e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Ketoacyl-synt_C PF02801.17 EFE43487.1 - 9.6e-34 115.7 0.3 1.3e-33 115.3 0.2 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.21 EFE43487.1 - 1.8e-13 50.5 0.5 3.2e-12 46.4 0.1 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_C PF02803.13 EFE43487.1 - 0.0082 15.5 0.4 0.0082 15.5 0.3 2.1 2 1 0 2 2 2 1 Thiolase, C-terminal domain Arginase PF00491.16 EFE43488.1 - 7.9e-85 284.5 0.2 9.7e-85 284.2 0.2 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 EFE43488.1 - 0.00079 19.6 0.2 0.0018 18.4 0.1 1.6 1 0 0 1 1 1 1 UPF0489 domain Ras PF00071.17 EFE43489.1 - 7.8e-53 178.1 0.0 9.7e-53 177.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE43489.1 - 2.5e-16 60.2 0.0 3.8e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE43489.1 - 6.5e-07 28.7 0.0 8.3e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DNA_mis_repair PF01119.14 EFE43490.1 - 9.4e-33 112.1 0.2 3e-32 110.5 0.0 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 EFE43490.1 - 1.7e-14 53.6 0.0 3.6e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EFE43490.1 - 2.2e-10 40.2 0.0 4.8e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DSPc PF00782.15 EFE43491.1 - 3.8e-07 29.7 0.0 3.9e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain AMP-binding PF00501.23 EFE43492.1 - 0 1414.1 0.0 3.9e-89 298.9 0.0 5.3 5 0 0 5 5 5 5 AMP-binding enzyme Condensation PF00668.15 EFE43492.1 - 0 1262.5 0.0 2.1e-52 177.8 0.0 9.9 9 2 0 9 9 9 9 Condensation domain PP-binding PF00550.20 EFE43492.1 - 2.5e-71 235.8 9.6 3.6e-11 43.1 0.2 8.5 8 0 0 8 8 8 7 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFE43492.1 - 1.8e-24 86.4 0.2 1.8e-06 28.8 0.0 5.9 5 0 0 5 5 5 5 AMP-binding enzyme C-terminal domain Transferase PF02458.10 EFE43492.1 - 1.2e-09 37.1 0.1 0.0012 17.3 0.0 4.6 5 0 0 5 5 5 3 Transferase family HxxPF_rpt PF13745.1 EFE43492.1 - 1.3e-05 25.4 0.0 1.4 9.2 0.0 4.3 4 0 0 4 4 4 2 HxxPF-repeated domain Sucrose_synth PF00862.14 EFE43492.1 - 0.52 8.2 0.0 0.9 7.4 0.0 1.2 1 0 0 1 1 1 0 Sucrose synthase GMP_synt_C PF00958.17 EFE43494.1 - 2.8e-38 129.5 0.0 5.3e-38 128.6 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.23 EFE43494.1 - 3.9e-38 130.8 0.0 7.5e-38 129.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 EFE43494.1 - 6.8e-11 41.5 0.1 1.4e-06 27.4 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 EFE43494.1 - 1.3e-08 34.5 0.0 2.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.8 EFE43494.1 - 0.002 17.4 0.0 0.016 14.5 0.0 2.0 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 EFE43494.1 - 0.0032 16.0 0.0 0.0071 14.9 0.0 1.6 2 0 0 2 2 2 1 tRNA methyl transferase ThiI PF02568.9 EFE43494.1 - 0.0038 16.6 0.0 0.0076 15.7 0.0 1.5 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Asn_synthase PF00733.16 EFE43494.1 - 0.0078 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase Arginosuc_synth PF00764.14 EFE43494.1 - 0.0089 15.0 0.1 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Arginosuccinate synthase PAPS_reduct PF01507.14 EFE43494.1 - 0.049 13.4 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.15 EFE43494.1 - 0.069 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 PP-loop family BCIP PF13862.1 EFE43495.1 - 1.5e-72 243.2 0.1 1.8e-72 242.9 0.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein CM_2 PF01817.16 EFE43496.1 - 9.1e-09 35.2 0.3 3.1e-06 27.1 0.0 2.9 2 1 0 2 2 2 2 Chorismate mutase type II WD40 PF00400.27 EFE43497.1 - 2.9e-23 80.8 4.7 1.6e-06 27.7 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 EFE43497.1 - 1.5e-05 23.3 5.0 0.048 11.7 0.1 4.1 3 1 1 4 4 4 4 Nucleoporin Nup120/160 APG6 PF04111.7 EFE43497.1 - 0.017 14.1 0.1 0.028 13.4 0.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Sad1_UNC PF07738.8 EFE43498.1 - 0.015 15.0 0.9 0.031 14.0 0.0 1.9 2 0 0 2 2 2 0 Sad1 / UNC-like C-terminal Plasmodium_Vir PF05795.6 EFE43499.1 - 0.0013 18.0 0.7 0.0014 17.8 0.5 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF4131 PF13567.1 EFE43499.1 - 0.0091 15.4 0.2 0.011 15.1 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) Conotoxin PF02950.12 EFE43499.1 - 0.047 14.4 0.7 0.11 13.3 0.5 1.6 1 0 0 1 1 1 0 Conotoxin tRNA-synt_1b PF00579.20 EFE43500.1 - 1.6e-10 40.5 0.0 2.1e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TRL PF13146.1 EFE43500.1 - 0.061 13.2 0.1 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 TRL-like protein family Dynamin_N PF00350.18 EFE43500.1 - 0.075 12.8 0.1 0.31 10.8 0.1 1.9 1 1 0 1 1 1 0 Dynamin family Ribosomal_S10 PF00338.17 EFE43501.1 - 1.5e-25 88.8 0.0 2.6e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PNP_UDP_1 PF01048.15 EFE43502.1 - 8.8e-13 47.7 0.5 1.6e-12 46.9 0.3 1.4 1 1 0 1 1 1 1 Phosphorylase superfamily Fcf2 PF08698.6 EFE43503.1 - 1.7e-26 92.1 1.8 2.6e-26 91.4 0.3 1.9 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing Peptidase_S41 PF03572.13 EFE43504.1 - 1.4e-10 40.8 0.0 2.7e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 Ribosomal_L7Ae PF01248.21 EFE43505.1 - 1.4e-25 88.5 0.0 1.7e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 EFE43505.1 - 0.00017 21.4 0.1 0.0002 21.2 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF221 PF02714.10 EFE43506.1 - 4.5e-111 370.8 16.9 4.5e-111 370.8 11.7 3.0 3 0 0 3 3 3 2 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFE43506.1 - 1.3e-42 145.0 1.4 1.3e-42 145.0 1.0 2.3 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EFE43506.1 - 3.9e-28 97.1 0.0 8.4e-28 96.1 0.0 1.5 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 EFE43506.1 - 6.4e-21 74.6 0.0 1.3e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) EHN PF06441.7 EFE43508.1 - 2.6e-34 117.5 4.2 6e-34 116.3 0.3 2.3 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 EFE43508.1 - 1e-12 48.4 0.7 3.5e-12 46.6 0.5 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE43508.1 - 4.4e-05 23.1 0.0 0.0031 17.1 0.0 2.7 3 0 0 3 3 3 1 alpha/beta hydrolase fold tRNA_NucTran2_2 PF13735.1 EFE43509.1 - 0.019 14.7 0.4 0.034 13.9 0.3 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative DUF4554 PF15091.1 EFE43509.1 - 0.052 12.2 1.6 0.097 11.3 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Pyridox_oxase_2 PF12766.2 EFE43513.1 - 2.4e-23 82.3 0.0 4e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase LRR_9 PF14580.1 EFE43514.1 - 1.6e-42 145.0 0.3 2.3e-42 144.5 0.0 1.4 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.2 EFE43514.1 - 1.5e-12 46.8 9.9 5e-06 26.0 0.2 3.8 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE43514.1 - 3.6e-07 29.8 2.5 3.6e-07 29.8 1.7 2.9 2 2 0 3 3 3 1 Leucine rich repeat HTH_38 PF13936.1 EFE43514.1 - 0.0032 16.9 0.4 0.0067 15.9 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain UPF0128 PF03673.8 EFE43514.1 - 0.068 12.4 0.5 0.11 11.7 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0128) LRR_7 PF13504.1 EFE43514.1 - 0.074 13.2 4.5 64 4.4 0.0 4.5 4 1 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.28 EFE43514.1 - 0.12 12.5 8.7 12 6.3 0.0 5.1 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.1 EFE43514.1 - 0.62 10.2 2.5 37 4.8 0.0 4.1 4 1 0 4 4 4 0 Leucine Rich repeat GDA1_CD39 PF01150.12 EFE43515.1 - 5.8e-95 318.3 0.0 8.1e-95 317.8 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Acyltransferase PF01553.16 EFE43516.1 - 1.3e-17 63.4 0.0 3.2e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase PSD1 PF07587.6 EFE43516.1 - 0.084 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) Pantoate_ligase PF02569.10 EFE43517.1 - 1.2e-71 240.7 0.0 2.8e-71 239.5 0.0 1.6 1 1 0 1 1 1 1 Pantoate-beta-alanine ligase DEAD PF00270.24 EFE43517.1 - 4.1e-38 130.5 0.3 5.2e-37 126.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE43517.1 - 1.2e-19 69.9 0.0 3.6e-19 68.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 EFE43517.1 - 4.5e-19 67.7 0.0 1e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 EFE43517.1 - 0.003 17.4 0.5 0.013 15.3 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit WD40 PF00400.27 EFE43518.1 - 7.4e-25 85.8 5.7 1.5e-05 24.6 0.1 7.1 7 2 0 7 7 7 5 WD domain, G-beta repeat DUF3423 PF11903.3 EFE43518.1 - 0.06 13.1 0.3 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3423) Fungal_trans_2 PF11951.3 EFE43519.1 - 2.8e-09 36.0 4.3 9e-08 31.1 0.2 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE43519.1 - 7.7e-06 25.7 10.1 1.9e-05 24.4 7.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF305 PF03713.8 EFE43519.1 - 0.42 10.4 6.7 0.9 9.3 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF305) F-box PF00646.28 EFE43520.1 - 1.6e-05 24.4 0.2 3.5e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE43520.1 - 5.9e-05 22.7 0.7 0.00013 21.6 0.5 1.6 1 0 0 1 1 1 1 F-box-like PPR_2 PF13041.1 EFE43521.1 - 3.3e-40 135.8 11.2 2.2e-09 37.1 0.0 13.5 11 3 4 15 15 15 10 PPR repeat family PPR_3 PF13812.1 EFE43521.1 - 1.5e-28 96.5 25.4 4.7e-05 23.3 0.0 14.4 16 0 0 16 16 16 7 Pentatricopeptide repeat domain PPR PF01535.15 EFE43521.1 - 2.9e-25 86.4 13.4 0.00041 20.1 0.0 13.2 14 0 0 14 14 14 6 PPR repeat PPR_1 PF12854.2 EFE43521.1 - 3.6e-18 64.7 1.4 7.2e-07 28.5 0.0 9.6 11 0 0 11 11 11 3 PPR repeat RPM2 PF08579.6 EFE43521.1 - 3.3e-08 33.6 0.3 3.9e-06 26.9 0.0 3.8 4 0 0 4 4 4 1 Mitochondrial ribonuclease P subunit (RPM2) ECSIT PF06239.6 EFE43521.1 - 0.0016 17.3 0.2 2 7.2 0.0 3.4 3 0 0 3 3 3 2 Evolutionarily conserved signalling intermediate in Toll pathway Proteasome PF00227.21 EFE43523.1 - 7.4e-48 162.3 0.0 9.2e-48 162.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit SCP2 PF02036.12 EFE43523.1 - 0.022 15.0 0.0 0.065 13.5 0.0 1.7 2 0 0 2 2 2 0 SCP-2 sterol transfer family DUF3650 PF12368.3 EFE43523.1 - 0.72 9.3 3.6 0.37 10.3 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3650) DUF2373 PF10180.4 EFE43524.1 - 5.8e-22 77.0 0.0 1e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Spc97_Spc98 PF04130.8 EFE43525.1 - 1e-118 397.0 0.0 1.5e-118 396.4 0.0 1.3 1 0 0 1 1 1 1 Spc97 / Spc98 family Pkinase PF00069.20 EFE43528.1 - 2.5e-60 203.8 0.0 3.7e-60 203.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43528.1 - 2.1e-41 141.7 0.0 3.2e-41 141.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE43528.1 - 8.1e-10 38.1 0.0 8.3e-07 28.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 EFE43528.1 - 0.0026 16.8 0.0 0.005 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RepL PF05732.6 EFE43528.1 - 0.037 13.2 0.1 0.071 12.3 0.0 1.4 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) Rad9 PF04139.8 EFE43529.1 - 2.6e-58 197.0 0.0 3.2e-58 196.8 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.11 EFE43529.1 - 7.2e-05 21.6 0.0 0.00075 18.3 0.0 2.1 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 CorA PF01544.13 EFE43529.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein RCC1 PF00415.13 EFE43530.1 - 6.1e-33 112.8 4.5 1.8e-08 34.4 0.2 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EFE43530.1 - 1.2e-17 62.9 18.0 1.2e-06 27.9 0.1 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Mannitol_dh_C PF08125.8 EFE43531.1 - 3.5e-46 157.3 0.0 6.1e-46 156.5 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.18 EFE43531.1 - 1.5e-18 67.1 0.6 3.5e-18 65.9 0.1 1.9 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain NAD_Gly3P_dh_N PF01210.18 EFE43531.1 - 0.0099 15.6 0.4 0.061 13.0 0.1 2.4 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Sec34 PF04136.10 EFE43533.1 - 3.6e-29 101.5 0.2 8.1e-29 100.3 0.1 1.6 1 0 0 1 1 1 1 Sec34-like family SYCE1 PF15233.1 EFE43533.1 - 0.061 13.2 0.2 0.49 10.3 0.1 2.2 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 Exo70 PF03081.10 EFE43533.1 - 0.16 10.7 1.7 5.3 5.7 0.0 3.1 3 0 0 3 3 3 0 Exo70 exocyst complex subunit NifW PF03206.9 EFE43533.1 - 0.19 11.8 1.0 11 6.1 0.0 3.1 3 0 0 3 3 3 0 Nitrogen fixation protein NifW Pkinase PF00069.20 EFE43535.1 - 2.6e-14 53.0 0.0 6.1e-11 41.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43535.1 - 7.6e-11 41.5 0.0 4e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE43535.1 - 0.2 10.5 0.0 0.4 9.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Aldose_epim PF01263.15 EFE43537.1 - 2.3e-49 168.1 0.2 3e-49 167.7 0.1 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase BRCT PF00533.21 EFE43537.1 - 0.053 13.6 0.1 0.33 11.1 0.0 2.2 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Rogdi_lz PF10259.4 EFE43538.1 - 0.081 12.0 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein Actin PF00022.14 EFE43539.1 - 2.1e-24 85.6 0.0 6.7e-21 74.1 0.0 2.5 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.8 EFE43539.1 - 0.044 12.3 0.0 0.15 10.6 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein XPG_I PF00867.13 EFE43540.1 - 9.6e-22 76.8 0.1 2.3e-21 75.6 0.1 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EFE43540.1 - 1.5e-07 31.6 0.0 3.7e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain CTP_transf_1 PF01148.15 EFE43541.1 - 3.5e-15 56.3 6.8 4.9e-15 55.9 4.7 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Peptidase_M24 PF00557.19 EFE43542.1 - 8.5e-45 152.8 0.0 9.6e-45 152.7 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 FAD_binding_3 PF01494.14 EFE43543.1 - 1.4e-10 40.8 0.0 1.8e-09 37.1 0.0 2.5 1 1 0 1 1 1 1 FAD binding domain SE PF08491.5 EFE43543.1 - 0.0025 16.6 0.0 0.0052 15.6 0.0 1.5 1 1 0 1 1 1 1 Squalene epoxidase Sugar_tr PF00083.19 EFE43545.1 - 1.4e-79 267.8 23.5 1.6e-79 267.6 16.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE43545.1 - 2e-13 49.7 39.7 2e-10 39.9 9.4 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily Ribosomal_S8 PF00410.14 EFE43546.1 - 6.9e-17 61.4 0.0 1.4e-16 60.4 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S8 PIP5K PF01504.13 EFE43548.1 - 6.7e-62 208.8 0.6 1.3e-61 207.9 0.4 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 EFE43548.1 - 2.3e-29 102.3 0.1 3.5e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 EFE43548.1 - 5.4e-15 55.0 4.1 5.4e-15 55.0 2.9 2.0 2 0 0 2 2 2 1 FYVE zinc finger C1_1 PF00130.17 EFE43548.1 - 0.0091 15.7 2.6 0.026 14.2 1.8 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) XPC-binding PF09280.6 EFE43548.1 - 0.24 10.9 1.9 0.66 9.4 1.3 1.8 1 0 0 1 1 1 0 XPC-binding domain TPP1 PF10341.4 EFE43549.1 - 2.1e-16 59.8 0.0 4.2e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD DUF1769 PF08588.5 EFE43552.1 - 9e-26 89.5 0.2 1.9e-25 88.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Iso_dh PF00180.15 EFE43553.1 - 3.5e-89 299.1 0.1 8.8e-89 297.8 0.0 1.5 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ICMT PF04140.9 EFE43553.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PK PF00224.16 EFE43555.1 - 1.9e-153 510.2 7.4 1.6e-124 415.0 3.1 2.2 1 1 1 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.11 EFE43555.1 - 5.4e-32 109.7 0.0 1.4e-31 108.5 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 EFE43555.1 - 3.6e-05 22.7 0.6 0.0001 21.2 0.5 1.7 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family SUR7 PF06687.7 EFE43556.1 - 1.2e-34 119.8 1.3 2.7e-34 118.6 0.9 1.6 1 1 0 1 1 1 1 SUR7/PalI family Tweety PF04906.8 EFE43556.1 - 0.043 12.2 0.1 0.2 10.0 0.0 1.9 2 0 0 2 2 2 0 Tweety DUF1212 PF06738.7 EFE43556.1 - 0.18 11.2 3.8 0.34 10.3 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) Ribosomal_S17 PF00366.15 EFE43558.1 - 6.1e-30 103.0 0.9 8.9e-30 102.5 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Spc7_N PF15402.1 EFE43559.1 - 1.3e-294 979.9 39.3 1.9e-294 979.3 27.3 1.3 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.6 EFE43559.1 - 9.9e-104 346.5 1.9 9.9e-104 346.5 1.3 1.6 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF745 PF05335.8 EFE43559.1 - 0.0054 16.2 2.4 0.016 14.7 1.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF745) Pil1 PF13805.1 EFE43561.1 - 1.4e-130 434.3 1.4 9e-69 231.6 0.1 2.1 2 0 0 2 2 2 2 Eisosome component PIL1 XPG_N PF00752.12 EFE43562.1 - 7.6e-35 119.2 0.0 1.8e-34 118.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 EFE43562.1 - 2.6e-24 85.1 0.0 6.7e-24 83.7 0.0 1.8 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 EFE43562.1 - 0.0012 19.0 0.0 0.0047 17.1 0.0 2.1 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.11 EFE43562.1 - 0.0045 17.0 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family WD40 PF00400.27 EFE43563.1 - 7.1e-14 51.0 18.0 4.6e-10 38.9 0.2 7.5 9 0 0 9 9 9 3 WD domain, G-beta repeat Metallophos PF00149.23 EFE43564.1 - 3.8e-42 143.9 0.2 5.3e-42 143.4 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mito_fiss_reg PF05308.6 EFE43564.1 - 1.4 8.2 7.3 0.16 11.3 2.1 1.6 2 0 0 2 2 2 0 Mitochondrial fission regulator HIRA_B PF09453.5 EFE43565.1 - 7.2e-05 22.2 0.5 0.0002 20.8 0.4 1.8 1 0 0 1 1 1 1 HIRA B motif WD40 PF00400.27 EFE43566.1 - 1.2e-16 59.8 1.7 2.5e-05 23.9 0.1 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.6 EFE43566.1 - 0.0039 16.9 0.0 0.0081 15.8 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Grp1_Fun34_YaaH PF01184.14 EFE43571.1 - 1.2e-72 243.6 16.8 1.5e-72 243.3 11.6 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family ANTH PF07651.11 EFE43572.1 - 9.3e-16 57.3 0.0 1.8e-08 33.4 0.0 2.2 2 0 0 2 2 2 2 ANTH domain HWE_HK PF07536.9 EFE43572.1 - 0.057 13.8 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 HWE histidine kinase DUF3024 PF11225.3 EFE43573.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) Golgin_A5 PF09787.4 EFE43573.1 - 7.2 5.0 7.0 9.8 4.5 4.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Memo PF01875.12 EFE43574.1 - 3.1e-23 82.0 0.0 4.5e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Memo-like protein Rad4 PF03835.10 EFE43575.1 - 9.1e-16 57.5 5.4 1.5e-15 56.8 3.7 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.14 EFE43575.1 - 2.9e-13 50.0 0.5 6.6e-13 48.8 0.3 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box PF00646.28 EFE43577.1 - 0.14 11.8 0.6 0.29 10.8 0.4 1.6 1 0 0 1 1 1 0 F-box domain PRANC PF09372.5 EFE43577.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 PRANC domain WD40 PF00400.27 EFE43578.1 - 1.7e-16 59.3 8.7 0.0036 17.1 0.0 8.3 9 0 0 9 9 9 4 WD domain, G-beta repeat PQQ_2 PF13360.1 EFE43578.1 - 1.6e-06 27.7 0.3 3.1e-05 23.5 0.1 2.8 2 1 0 2 2 2 1 PQQ-like domain Nup160 PF11715.3 EFE43578.1 - 0.037 12.1 0.0 0.071 11.2 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Lactonase PF10282.4 EFE43578.1 - 0.037 13.0 0.0 0.13 11.2 0.0 1.8 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller CDC45 PF02724.9 EFE43580.1 - 0.0073 14.4 1.9 0.0073 14.4 0.8 1.3 1 1 0 1 1 1 1 CDC45-like protein FLO_LFY PF01698.11 EFE43580.1 - 5.1 5.8 10.7 8.1 5.1 7.4 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein COesterase PF00135.23 EFE43581.1 - 2e-61 208.3 0.0 2.7e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE43581.1 - 7.5e-07 28.9 0.1 2.2e-06 27.3 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold MARVEL PF01284.18 EFE43582.1 - 0.0004 20.2 1.2 0.00054 19.7 0.9 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF912 PF06024.7 EFE43582.1 - 0.15 12.1 0.1 0.42 10.6 0.0 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) EF-1_beta_acid PF10587.4 EFE43582.1 - 2 8.6 4.6 3.7 7.7 3.2 1.4 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region NAD_binding_6 PF08030.7 EFE43584.1 - 0.034 14.0 0.1 2.4 8.0 0.0 2.2 2 0 0 2 2 2 0 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EFE43584.1 - 0.18 12.4 0.2 2 8.9 0.0 2.3 1 1 0 2 2 2 0 Oxidoreductase NAD-binding domain Metallophos PF00149.23 EFE43585.1 - 1e-13 51.1 0.5 1.6e-13 50.5 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE43585.1 - 8.4e-05 22.4 0.1 0.00015 21.6 0.1 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain GCD14 PF08704.5 EFE43586.1 - 1.2e-06 28.2 0.0 0.0006 19.3 0.0 2.5 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 EFE43586.1 - 0.0083 15.7 0.0 3.8 7.0 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_26 PF13659.1 EFE43586.1 - 0.073 13.1 0.0 0.6 10.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 EFE43586.1 - 0.15 12.5 0.0 13 6.3 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 EFE43586.1 - 0.15 12.6 0.1 0.61 10.6 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain HET PF06985.6 EFE43587.1 - 4.8e-21 75.3 0.0 8.6e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.11 EFE43588.1 - 1.7e-39 135.5 53.7 1.1e-37 129.6 36.7 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE43588.1 - 8.8e-20 70.4 20.5 6e-17 61.0 12.3 2.4 2 1 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE43588.1 - 3.8e-12 45.5 15.9 3.8e-12 45.5 11.0 3.1 3 1 0 3 3 3 2 Sugar (and other) transporter Peptidase_M56 PF05569.6 EFE43588.1 - 0.022 13.7 0.1 0.041 12.8 0.1 1.5 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF1705 PF08019.7 EFE43588.1 - 0.099 12.1 0.1 0.099 12.1 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1705) BatD PF13584.1 EFE43588.1 - 0.49 8.9 2.5 0.38 9.2 0.1 1.9 2 0 0 2 2 2 0 Oxygen tolerance DUF2839 PF10999.3 EFE43588.1 - 1.6 8.8 4.6 3.2 7.8 0.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2839) Exo_endo_phos PF03372.18 EFE43589.1 - 1.3e-21 77.7 0.0 2e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 EFE43589.1 - 4.2e-14 51.7 9.9 4.9e-08 32.4 1.5 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE43589.1 - 5.7e-08 32.4 6.7 1.3e-07 31.2 4.3 1.9 1 1 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.28 EFE43589.1 - 1.8e-06 27.1 6.3 0.028 14.3 0.0 4.4 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_7 PF13504.1 EFE43589.1 - 0.00013 21.5 13.0 0.12 12.6 0.0 4.5 4 0 0 4 4 4 3 Leucine rich repeat LRR_6 PF13516.1 EFE43589.1 - 0.39 10.9 0.1 0.39 10.9 0.0 4.2 5 0 0 5 5 5 0 Leucine Rich repeat Spt20 PF12090.3 EFE43589.1 - 1.2 8.4 9.0 2.5 7.4 6.2 1.5 1 0 0 1 1 1 0 Spt20 family PE-PPE PF08237.6 EFE43590.1 - 0.066 12.6 0.2 0.073 12.4 0.1 1.1 1 0 0 1 1 1 0 PE-PPE domain Ctr PF04145.10 EFE43591.1 - 0.00015 21.8 0.3 0.00015 21.8 0.2 1.9 1 1 1 2 2 2 1 Ctr copper transporter family Pex24p PF06398.6 EFE43591.1 - 0.0008 18.3 0.0 0.00095 18.0 0.0 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Sre PF03125.13 EFE43591.1 - 0.001 18.0 0.6 0.0012 17.8 0.4 1.0 1 0 0 1 1 1 1 C. elegans Sre G protein-coupled chemoreceptor DUF788 PF05620.6 EFE43591.1 - 0.0015 18.4 2.4 0.0015 18.4 1.6 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF788) 7tm_1 PF00001.16 EFE43591.1 - 0.0049 16.0 1.5 0.0065 15.6 1.0 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2500 PF10694.4 EFE43591.1 - 0.0059 16.5 0.1 0.0091 15.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2500) PrgI PF12666.2 EFE43591.1 - 0.0096 16.0 1.7 0.012 15.6 1.2 1.3 1 0 0 1 1 1 1 PrgI family protein FHIPEP PF00771.15 EFE43591.1 - 0.012 14.0 0.0 0.012 13.9 0.0 1.1 1 0 0 1 1 1 0 FHIPEP family Neur_chan_memb PF02932.11 EFE43591.1 - 0.021 14.7 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BatD PF13584.1 EFE43591.1 - 0.023 13.3 0.1 0.028 13.0 0.1 1.1 1 0 0 1 1 1 0 Oxygen tolerance Plasmodium_Vir PF05795.6 EFE43591.1 - 0.027 13.6 7.9 0.037 13.2 5.4 1.3 1 1 0 1 1 1 0 Plasmodium vivax Vir protein Conotoxin PF02950.12 EFE43591.1 - 0.04 14.7 0.1 0.073 13.8 0.1 1.5 1 0 0 1 1 1 0 Conotoxin 2TM PF13239.1 EFE43591.1 - 0.041 13.9 0.3 0.057 13.4 0.2 1.4 1 0 0 1 1 1 0 2TM domain SID-1_RNA_chan PF13965.1 EFE43591.1 - 0.048 11.8 3.9 1.1 7.2 0.1 2.0 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 FAM176 PF14851.1 EFE43591.1 - 0.054 13.1 0.3 0.066 12.8 0.2 1.1 1 0 0 1 1 1 0 FAM176 family Peptidase_A21 PF03566.8 EFE43591.1 - 0.059 11.4 0.2 0.065 11.3 0.2 1.1 1 0 0 1 1 1 0 Peptidase family A21 LETM1 PF07766.8 EFE43591.1 - 0.062 12.3 2.8 0.073 12.0 2.0 1.1 1 0 0 1 1 1 0 LETM1-like protein Baculo_11_kDa PF06143.6 EFE43591.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family OAD_gamma PF04277.8 EFE43591.1 - 0.11 12.8 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4131 PF13567.1 EFE43591.1 - 0.14 11.5 0.9 0.17 11.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Cnd1_N PF12922.2 EFE43591.1 - 0.15 11.6 0.5 0.24 11.0 0.3 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term DUF4181 PF13789.1 EFE43591.1 - 1.1 9.1 9.0 2.4 8.0 6.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4181) FLO_LFY PF01698.11 EFE43591.1 - 1.1 7.9 8.0 1.6 7.4 5.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF1168 PF06658.7 EFE43591.1 - 2.2 7.8 17.7 2.7 7.4 12.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) PBP1_TM PF14812.1 EFE43591.1 - 3 8.2 14.0 5 7.5 9.7 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ETRAMP PF09716.5 EFE43591.1 - 6.9 6.6 6.4 15 5.6 4.5 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Peptidase_S49_N PF08496.5 EFE43591.1 - 9.8 5.9 8.5 13 5.5 5.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Cas_Csy4 PF09618.5 EFE43591.1 - 9.9 5.9 7.4 17 5.1 5.1 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) TLV_coat PF00429.14 EFE43592.1 - 6.1 5.1 5.4 7.5 4.8 3.8 1.0 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) Methyltransf_11 PF08241.7 EFE43593.1 - 1.8e-09 37.9 0.0 4.1e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE43593.1 - 7.8e-09 35.8 0.0 1.7e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE43593.1 - 2.7e-06 27.0 0.0 4.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE43593.1 - 5.9e-06 26.0 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE43593.1 - 6.9e-06 25.3 0.0 1.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFE43593.1 - 4.1e-05 23.9 0.1 0.0004 20.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE43593.1 - 6.1e-05 23.5 0.0 0.00012 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE43593.1 - 0.00057 19.9 0.0 0.0014 18.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EFE43593.1 - 0.059 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Period_C PF12114.3 EFE43593.1 - 0.38 10.3 2.5 17 4.9 0.0 2.3 2 0 0 2 2 2 0 Period protein 2/3C-terminal region Pex14_N PF04695.8 EFE43593.1 - 0.44 10.5 10.1 0.049 13.6 3.2 2.1 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region 4HBT_2 PF13279.1 EFE43595.1 - 0.0024 18.3 0.0 0.0024 18.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily PspB PF06667.7 EFE43595.1 - 0.042 13.7 0.1 0.059 13.3 0.1 1.2 1 0 0 1 1 1 0 Phage shock protein B DUF4200 PF13863.1 EFE43596.1 - 0.012 15.6 3.0 0.012 15.6 2.1 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4200) Tweety PF04906.8 EFE43596.1 - 1.3 7.3 6.0 1.6 7.0 3.6 1.5 1 1 0 1 1 1 0 Tweety TBPIP PF07106.8 EFE43596.1 - 3.5 7.1 10.8 0.61 9.6 4.0 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Flavin_Reduct PF01613.13 EFE43597.1 - 1.8e-24 86.3 2.7 5.4e-24 84.7 1.9 1.8 1 1 0 1 1 1 1 Flavin reductase like domain Ribosomal_60s PF00428.14 EFE43598.1 - 0.028 14.8 4.9 0.054 13.8 3.4 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Vps5 PF09325.5 EFE43599.1 - 7.4e-89 297.0 4.7 1.2e-88 296.3 3.3 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 EFE43599.1 - 3.9e-25 87.8 0.0 1e-24 86.4 0.0 1.8 1 0 0 1 1 1 1 PX domain Aldolase_II PF00596.16 EFE43600.1 - 1.7e-40 138.5 0.0 2e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Calreticulin PF00262.13 EFE43601.1 - 2.6e-167 556.0 16.8 2.6e-167 556.0 11.7 1.6 2 0 0 2 2 2 1 Calreticulin family DUF4064 PF13273.1 EFE43601.1 - 0.038 14.0 0.0 0.094 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Aldedh PF00171.17 EFE43602.1 - 7.5e-136 453.1 0.8 1e-135 452.6 0.6 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pkinase_C PF00433.19 EFE43602.1 - 0.12 12.9 0.0 0.35 11.4 0.0 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain Peptidase_M24 PF00557.19 EFE43603.1 - 1e-37 129.7 0.5 1.4e-37 129.3 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Med19 PF10278.4 EFE43603.1 - 0.22 11.2 5.7 0.42 10.2 3.9 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CDC45 PF02724.9 EFE43603.1 - 1 7.3 3.8 1.4 6.8 2.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Dynamitin PF04912.9 EFE43605.1 - 5.7e-30 104.4 2.5 7.6e-15 54.6 0.3 2.2 2 0 0 2 2 2 2 Dynamitin DivIC PF04977.10 EFE43605.1 - 0.0013 18.1 14.5 0.008 15.6 1.1 3.6 3 0 0 3 3 3 1 Septum formation initiator TPR_MLP1_2 PF07926.7 EFE43605.1 - 0.0045 16.7 3.3 0.0045 16.7 2.3 3.5 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein FH2 PF02181.18 EFE43605.1 - 0.005 15.7 2.6 0.016 14.1 0.2 2.6 3 0 0 3 3 3 1 Formin Homology 2 Domain Laminin_II PF06009.7 EFE43605.1 - 0.0068 16.1 0.5 0.0068 16.1 0.4 3.1 4 1 0 4 4 3 1 Laminin Domain II DUF3166 PF11365.3 EFE43605.1 - 0.0088 16.4 2.1 0.0088 16.4 1.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3166) IncA PF04156.9 EFE43605.1 - 0.011 15.4 7.4 0.44 10.1 0.7 3.3 3 0 0 3 3 3 0 IncA protein DUF4200 PF13863.1 EFE43605.1 - 0.011 15.7 11.3 0.9 9.4 1.9 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) ADIP PF11559.3 EFE43605.1 - 0.017 15.0 9.4 0.14 12.0 0.4 3.4 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding TBPIP PF07106.8 EFE43605.1 - 0.1 12.1 6.7 0.95 8.9 0.6 3.1 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SseC PF04888.7 EFE43605.1 - 0.13 11.6 3.9 0.22 10.8 2.7 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Viral_P18 PF04521.8 EFE43605.1 - 0.13 11.7 10.8 0.54 9.7 0.7 3.6 3 1 1 4 4 4 0 ssRNA positive strand viral 18kD cysteine rich protein DUF4446 PF14584.1 EFE43605.1 - 0.24 11.2 2.7 3.7 7.3 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF4446) Mnd1 PF03962.10 EFE43605.1 - 0.27 10.9 10.1 1.4 8.5 0.6 2.8 3 0 0 3 3 3 0 Mnd1 family APG6 PF04111.7 EFE43605.1 - 0.36 9.8 9.6 2 7.4 0.5 2.4 3 0 0 3 3 3 0 Autophagy protein Apg6 Jnk-SapK_ap_N PF09744.4 EFE43605.1 - 0.36 10.7 6.9 0.36 10.7 0.4 2.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Prefoldin_2 PF01920.15 EFE43605.1 - 0.4 10.4 15.2 1.3 8.7 2.7 3.5 3 1 0 3 3 3 0 Prefoldin subunit Fmp27_WPPW PF10359.4 EFE43605.1 - 0.46 8.8 4.6 4.6 5.5 0.3 2.8 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain Fib_alpha PF08702.5 EFE43605.1 - 0.58 10.2 2.9 1.3 9.1 0.2 2.8 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family LPP PF04728.8 EFE43605.1 - 0.59 9.9 9.3 0.14 11.9 0.2 3.7 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Atg14 PF10186.4 EFE43605.1 - 0.69 8.7 10.7 1.2 8.0 0.9 2.9 2 1 1 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 COG2 PF06148.6 EFE43605.1 - 0.71 9.7 4.8 2.5 7.9 0.2 3.2 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF342 PF03961.8 EFE43605.1 - 0.71 8.2 3.3 4.8 5.4 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF342) DUF3584 PF12128.3 EFE43605.1 - 0.72 7.1 13.4 0.13 9.5 2.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) DUF3373 PF11853.3 EFE43605.1 - 1 7.8 5.8 1.6 7.1 0.4 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3373) SlyX PF04102.7 EFE43605.1 - 1.7 9.0 14.7 2.7 8.4 1.0 4.6 4 1 0 4 4 4 0 SlyX Spectrin PF00435.16 EFE43605.1 - 2.4 8.4 11.1 30 4.9 2.5 3.5 3 0 0 3 3 3 0 Spectrin repeat Spc7 PF08317.6 EFE43605.1 - 2.5 6.6 8.8 0.54 8.8 0.6 2.7 3 0 0 3 3 3 0 Spc7 kinetochore protein Spc24 PF08286.6 EFE43605.1 - 2.5 7.8 13.3 1.2 8.8 1.6 3.3 4 0 0 4 4 4 0 Spc24 subunit of Ndc80 Snapin_Pallidin PF14712.1 EFE43605.1 - 2.5 8.4 10.1 1.8 8.9 0.5 4.1 3 2 0 3 3 3 0 Snapin/Pallidin FliD_C PF07195.7 EFE43605.1 - 3.1 7.0 6.1 1.1 8.5 1.4 2.1 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus THOC7 PF05615.8 EFE43605.1 - 3.2 8.0 12.1 1.5 9.1 2.2 2.9 3 0 0 3 3 2 0 Tho complex subunit 7 DUF4140 PF13600.1 EFE43605.1 - 4.9 7.6 19.1 3.8 7.9 1.6 4.4 3 2 1 4 4 4 0 N-terminal domain of unknown function (DUF4140) Vfa1 PF08432.5 EFE43605.1 - 5.4 6.9 10.6 8.7 6.3 0.5 2.7 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 AcylCoA_dehyd_C PF12186.3 EFE43605.1 - 5.9 6.7 6.5 5.7 6.8 0.0 3.0 3 1 0 3 3 2 0 Acyl-CoA dehydrogenase C terminal DUF4337 PF14235.1 EFE43605.1 - 8.9 6.1 14.4 1.2 8.9 0.3 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4337) MbeD_MobD PF04899.7 EFE43605.1 - 9.4 6.2 8.5 0.65 9.9 0.8 2.9 4 0 0 4 4 3 0 MbeD/MobD like Syntaxin PF00804.20 EFE43605.1 - 9.5 6.4 10.9 40 4.4 3.7 3.5 2 1 0 2 2 2 0 Syntaxin Glyco_transf_22 PF03901.12 EFE43606.1 - 2.7e-05 23.3 0.5 3.1e-05 23.1 0.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family UCH PF00443.24 EFE43607.1 - 1.3e-58 198.2 1.5 1.3e-58 198.2 1.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE43607.1 - 2.9e-26 92.5 6.5 1.7e-22 80.2 0.1 3.1 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Ycf1 PF05758.7 EFE43607.1 - 0.81 7.3 12.7 0.013 13.2 3.8 1.5 2 0 0 2 2 2 0 Ycf1 DUF2215 PF10225.4 EFE43607.1 - 1.7 7.9 6.5 3.7 6.9 4.5 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) V_ATPase_I PF01496.14 EFE43607.1 - 3.2 5.4 4.0 6 4.5 2.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4557 PF15101.1 EFE43607.1 - 5 6.9 10.4 16 5.2 7.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Ank_2 PF12796.2 EFE43609.1 - 5.5e-29 100.3 0.0 1.2e-17 64.0 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFE43609.1 - 7.5e-22 76.0 5.4 1.4e-08 34.1 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 EFE43609.1 - 5.9e-21 74.0 4.8 1.8e-07 31.2 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE43609.1 - 7.2e-20 70.9 0.5 6e-06 26.6 0.0 4.0 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE43609.1 - 1e-16 59.3 1.2 2.4e-05 24.1 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat SMC_N PF02463.14 EFE43610.1 - 9.4e-49 165.5 0.0 1.2e-47 161.9 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EFE43610.1 - 5.3e-31 107.0 0.6 3.5e-30 104.4 0.0 2.8 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 EFE43610.1 - 4.5e-09 36.6 10.8 2.7e-06 27.5 0.3 3.9 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.1 EFE43610.1 - 1.7e-05 25.2 18.0 1.7e-05 25.2 12.5 6.4 2 2 3 5 5 3 1 AAA domain DUF4200 PF13863.1 EFE43610.1 - 0.0002 21.2 4.5 0.0002 21.2 3.1 9.1 4 3 5 9 9 5 3 Domain of unknown function (DUF4200) AAA_29 PF13555.1 EFE43610.1 - 0.00031 20.2 0.0 0.00064 19.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.1 EFE43610.1 - 0.0019 18.0 0.0 0.0098 15.7 0.0 2.3 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Reo_sigmaC PF04582.7 EFE43610.1 - 0.015 14.5 27.8 0.044 12.9 2.0 4.8 4 1 1 6 6 6 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 EFE43610.1 - 0.021 14.5 0.5 0.021 14.5 0.4 8.3 4 3 2 7 7 7 0 TPR/MLP1/MLP2-like protein AAA_13 PF13166.1 EFE43610.1 - 0.1 11.0 98.2 0.0064 15.0 14.4 6.8 4 3 3 7 7 7 0 AAA domain NPV_P10 PF05531.7 EFE43610.1 - 1.2 9.4 35.8 4 7.7 1.2 8.4 7 1 1 8 8 8 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 EFE43610.1 - 5.5 6.7 53.8 0.82 9.4 3.4 8.4 4 3 4 8 8 8 0 Protein of unknown function (DUF1664) Tropomyosin PF00261.15 EFE43610.1 - 8.1 5.4 113.2 0.14 11.2 14.1 6.5 4 2 2 6 6 6 0 Tropomyosin Spc7 PF08317.6 EFE43610.1 - 9.6 4.7 99.5 0.0094 14.6 9.2 6.5 3 2 2 6 6 6 0 Spc7 kinetochore protein E3_binding PF02817.12 EFE43612.1 - 1.4e-09 37.4 0.0 2.2e-08 33.6 0.0 2.4 2 0 0 2 2 2 1 e3 binding domain PPK2 PF03976.9 EFE43612.1 - 0.11 11.7 0.0 3.8 6.7 0.0 2.1 1 1 1 2 2 2 0 Polyphosphate kinase 2 (PPK2) Abhydrolase_2 PF02230.11 EFE43614.1 - 8.2e-28 97.3 0.0 4e-15 55.8 0.0 3.4 1 1 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EFE43614.1 - 1.2e-09 38.3 2.0 4.3e-09 36.5 1.4 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE43614.1 - 6.8e-07 29.1 0.0 1.8e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFE43614.1 - 0.00061 19.0 0.0 0.0021 17.2 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family LIP PF03583.9 EFE43614.1 - 0.01 15.0 0.0 0.058 12.5 0.0 1.9 2 0 0 2 2 2 0 Secretory lipase HNH_2 PF13391.1 EFE43615.1 - 4.6e-16 58.3 0.0 8.2e-16 57.5 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease WD40 PF00400.27 EFE43616.1 - 1.8e-32 110.0 4.8 1.1e-07 31.4 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 EFE43616.1 - 1.7e-06 27.8 0.2 0.0036 17.0 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A ATPgrasp_ST PF14397.1 EFE43616.1 - 0.063 12.3 0.0 0.096 11.7 0.0 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Peptidase_M18 PF02127.10 EFE43618.1 - 2.5e-138 461.2 0.0 3e-138 460.9 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Sugar_tr PF00083.19 EFE43619.1 - 5.9e-44 150.3 16.5 7.8e-44 149.9 11.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE43619.1 - 6.2e-37 127.1 31.8 5.6e-25 87.7 10.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 EFE43619.1 - 0.00028 19.5 21.0 0.0012 17.4 3.7 2.5 2 1 0 2 2 2 2 Vacuole effluxer Atg22 like OATP PF03137.15 EFE43619.1 - 0.0031 15.6 0.1 0.0078 14.3 0.0 1.7 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family HTH_38 PF13936.1 EFE43619.1 - 0.019 14.5 0.9 0.36 10.4 0.9 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4 PF04545.11 EFE43619.1 - 0.05 12.9 0.3 6.4 6.1 0.0 2.7 2 0 0 2 2 2 0 Sigma-70, region 4 Flu_PB1 PF00602.12 EFE43619.1 - 0.052 11.2 0.0 0.069 10.8 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Hydrolase_6 PF13344.1 EFE43620.1 - 1.2e-18 66.8 0.0 2.1e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE43620.1 - 1.2e-13 50.5 0.1 1.6e-12 46.9 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 EFE43620.1 - 2e-07 31.6 0.0 0.00017 22.0 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFE43620.1 - 0.0037 17.5 0.0 0.44 10.7 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase DUF1746 PF08508.5 EFE43622.1 - 3.6e-21 75.2 4.4 8.8e-20 70.7 0.1 2.3 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1746) CLP_protease PF00574.18 EFE43623.1 - 1e-43 149.1 0.1 1.2e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Clp protease DHDPS PF00701.17 EFE43623.1 - 0.0037 15.9 0.0 0.0044 15.6 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Clr5 PF14420.1 EFE43623.1 - 0.22 11.4 1.0 0.34 10.8 0.7 1.3 1 0 0 1 1 1 0 Clr5 domain AAA PF00004.24 EFE43624.1 - 2.6e-12 47.0 0.0 8.3e-12 45.4 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 EFE43624.1 - 1.7e-09 37.5 0.0 5.3e-07 29.4 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 EFE43624.1 - 4.4e-09 36.2 0.0 0.00078 19.3 0.0 2.5 2 0 0 2 2 2 2 Replication factor C C-terminal domain AAA_11 PF13086.1 EFE43624.1 - 0.00014 21.5 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFE43624.1 - 0.00063 19.8 0.2 0.038 14.1 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFE43624.1 - 0.0045 16.7 0.0 0.016 14.9 0.0 1.9 2 0 0 2 2 2 1 Part of AAA domain DUF2075 PF09848.4 EFE43624.1 - 0.0081 15.1 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 EFE43624.1 - 0.017 15.0 0.4 0.98 9.3 0.0 2.8 2 1 0 3 3 3 0 AAA ATPase domain AAA_24 PF13479.1 EFE43624.1 - 0.019 14.5 0.4 0.043 13.3 0.3 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFE43624.1 - 0.044 12.9 0.0 2 7.4 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MFS_1 PF07690.11 EFE43625.1 - 5e-41 140.5 49.4 5e-41 140.5 34.3 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE43625.1 - 2.9e-11 42.3 15.2 2.9e-11 42.3 10.6 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE43625.1 - 6.3e-10 38.2 31.8 3.3e-09 35.8 11.0 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter Sec20 PF03908.8 EFE43626.1 - 5.4e-16 58.0 2.4 1.5e-15 56.6 1.7 1.8 1 0 0 1 1 1 1 Sec20 Pyrophosphatase PF00719.14 EFE43627.1 - 1.1e-46 158.1 0.0 1.8e-46 157.4 0.0 1.4 1 1 0 1 1 1 1 Inorganic pyrophosphatase Dus PF01207.12 EFE43628.1 - 1.3e-41 142.4 0.0 3e-41 141.2 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) TFIIF_alpha PF05793.7 EFE43628.1 - 0.048 12.0 14.7 0.068 11.5 10.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BSP_II PF05432.6 EFE43628.1 - 0.55 9.4 17.8 0.86 8.8 12.4 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Daxx PF03344.10 EFE43628.1 - 1.3 7.3 19.7 1.9 6.8 13.7 1.1 1 0 0 1 1 1 0 Daxx Family Ycf1 PF05758.7 EFE43628.1 - 1.7 6.2 5.7 2.2 5.9 3.9 1.0 1 0 0 1 1 1 0 Ycf1 MIP-T3 PF10243.4 EFE43628.1 - 2.5 6.4 21.6 3.7 5.9 14.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF2890 PF11081.3 EFE43628.1 - 2.9 7.8 17.3 5 7.1 12.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Peptidase_M28 PF04389.12 EFE43629.1 - 7.5e-35 120.2 0.0 1.4e-34 119.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EFE43629.1 - 1.1e-17 63.4 0.2 2.7e-17 62.2 0.1 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M42 PF05343.9 EFE43629.1 - 0.0014 17.4 0.0 0.05 12.3 0.0 2.5 3 0 0 3 3 3 1 M42 glutamyl aminopeptidase SNF2_N PF00176.18 EFE43630.1 - 3.7e-58 196.6 0.1 5.7e-58 196.0 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE43630.1 - 2e-15 56.3 0.0 5.3e-15 55.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE43630.1 - 1.8e-07 31.1 0.0 4.3e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EFE43630.1 - 7.7e-07 28.7 0.0 1.9e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.1 EFE43632.1 - 0.024 13.8 0.1 0.026 13.7 0.1 1.0 1 0 0 1 1 1 0 rRNA-processing arch domain DUF498 PF04430.9 EFE43632.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) OAD_gamma PF04277.8 EFE43633.1 - 0.01 16.1 0.0 0.013 15.8 0.0 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain O-ag_pol_Wzy PF14296.1 EFE43633.1 - 0.016 13.7 0.2 0.019 13.5 0.1 1.0 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy Plasmodium_Vir PF05795.6 EFE43633.1 - 0.017 14.3 0.6 0.019 14.2 0.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4094 PF13334.1 EFE43633.1 - 0.018 15.3 0.1 0.028 14.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) ABC2_membrane_3 PF12698.2 EFE43633.1 - 0.023 13.7 0.0 0.026 13.5 0.0 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein UPF0542 PF15086.1 EFE43633.1 - 0.027 14.1 2.5 0.039 13.6 1.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 7tm_1 PF00001.16 EFE43633.1 - 0.04 13.0 0.3 0.048 12.7 0.2 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF3784 PF12650.2 EFE43633.1 - 0.079 12.9 0.6 0.13 12.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) STAG PF08514.6 EFE43633.1 - 0.1 12.3 0.7 0.16 11.6 0.5 1.3 1 0 0 1 1 1 0 STAG domain NfeD PF01957.13 EFE43633.1 - 0.1 12.7 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding ATP-synt_8 PF00895.15 EFE43633.1 - 0.76 10.0 2.9 1.3 9.2 1.9 1.5 1 1 0 1 1 1 0 ATP synthase protein 8 TRAM_LAG1_CLN8 PF03798.11 EFE43634.1 - 3.8e-33 114.7 15.1 7.4e-33 113.7 10.5 1.5 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 EFE43634.1 - 2.1e-22 78.3 1.4 3.1e-22 77.8 0.0 2.0 2 1 0 2 2 2 1 TRAM1-like protein T_cell_tran_alt PF15128.1 EFE43634.1 - 0.37 10.2 2.7 0.36 10.3 0.3 2.1 3 0 0 3 3 3 0 T-cell leukemia translocation-altered Hira PF07569.6 EFE43635.1 - 2e-77 259.3 0.0 3.3e-77 258.5 0.0 1.4 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.27 EFE43635.1 - 1.6e-29 100.7 10.3 2.8e-07 30.1 0.0 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat HIRA_B PF09453.5 EFE43635.1 - 2.5e-10 39.5 0.1 5.7e-10 38.4 0.1 1.6 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.7 EFE43635.1 - 0.0002 20.9 1.6 2.1 8.0 0.0 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.2 EFE43635.1 - 0.033 13.8 0.3 3.1 7.4 0.0 2.8 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term YchF-GTPase_C PF06071.8 EFE43636.1 - 2.3e-32 110.5 0.2 4.5e-32 109.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 EFE43636.1 - 1.9e-12 47.1 0.0 3.6e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE43636.1 - 0.0007 18.9 0.0 0.0015 17.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.16 EFE43636.1 - 0.0027 17.5 0.0 0.0096 15.7 0.0 2.0 1 1 0 1 1 1 1 TGS domain AAA_14 PF13173.1 EFE43636.1 - 0.055 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFE43636.1 - 0.14 11.8 0.4 3.9 7.1 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PUA PF01472.15 EFE43637.1 - 5.5e-14 51.6 0.4 7.3e-14 51.2 0.2 1.2 1 0 0 1 1 1 1 PUA domain RIC1 PF07064.8 EFE43638.1 - 9.7e-79 264.4 0.0 1.4e-78 263.9 0.0 1.2 1 0 0 1 1 1 1 RIC1 Striatin PF08232.7 EFE43638.1 - 0.62 10.3 7.7 1.1 9.5 4.6 1.8 2 0 0 2 2 2 0 Striatin family TPR_11 PF13414.1 EFE43639.1 - 1e-19 69.8 6.5 3.5e-17 61.8 1.5 2.4 1 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 EFE43639.1 - 3.6e-13 48.4 4.5 8.5e-06 25.1 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFE43639.1 - 4e-13 48.1 6.5 0.00012 21.7 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFE43639.1 - 2.3e-10 40.8 16.9 4.6e-08 33.5 2.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFE43639.1 - 2.6e-08 33.3 0.8 0.0012 18.8 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFE43639.1 - 9.9e-07 28.1 0.4 0.38 10.6 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFE43639.1 - 1.4e-05 24.8 3.1 4.6e-05 23.1 0.5 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFE43639.1 - 1.7e-05 25.0 6.0 0.021 15.4 0.4 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFE43639.1 - 1.9e-05 24.5 3.0 0.11 12.4 0.7 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat XPC-binding PF09280.6 EFE43639.1 - 0.00017 20.9 5.3 0.00018 20.8 2.5 1.9 2 0 0 2 2 2 1 XPC-binding domain TPR_19 PF14559.1 EFE43639.1 - 0.00019 21.6 1.8 0.00053 20.2 0.4 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFE43639.1 - 0.00066 19.2 1.8 0.84 9.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.12 EFE43639.1 - 0.036 14.3 0.5 1.3 9.2 0.1 2.6 3 0 0 3 3 2 0 Bacterial transcriptional activator domain TPR_6 PF13174.1 EFE43639.1 - 0.25 11.9 5.6 8 7.1 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Tim44 PF04280.10 EFE43640.1 - 5.4e-34 117.2 0.0 1.4e-33 115.9 0.0 1.7 1 0 0 1 1 1 1 Tim44-like domain Ribosomal_S11 PF00411.14 EFE43641.1 - 3.1e-06 27.3 0.1 1.2e-05 25.4 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S11 VPS9 PF02204.13 EFE43642.1 - 4.7e-17 61.9 0.1 1.2e-16 60.6 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.1 EFE43642.1 - 6.3e-15 54.8 0.4 1.5e-11 44.0 0.0 4.5 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFE43642.1 - 5.3e-09 36.2 0.0 0.00012 22.3 0.0 3.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE43642.1 - 5.2e-08 33.2 0.1 0.012 16.1 0.0 5.0 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE43642.1 - 1.7e-07 30.8 0.2 0.73 10.2 0.0 5.8 5 0 0 5 5 5 2 Ankyrin repeat PX PF00787.19 EFE43642.1 - 8.3e-06 25.5 0.6 8.3e-06 25.5 0.4 1.9 2 0 0 2 2 2 1 PX domain Ank PF00023.25 EFE43642.1 - 2e-05 24.1 0.3 0.039 13.7 0.0 4.6 5 0 0 5 5 5 1 Ankyrin repeat Herpes_gE PF02480.11 EFE43643.1 - 0.37 8.9 0.0 0.37 8.9 0.0 2.0 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Inhibitor_I78 PF11720.3 EFE43644.1 - 3.6e-16 58.6 0.0 5.5e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.13 EFE43644.1 - 0.00018 21.6 0.1 0.00026 21.0 0.1 1.4 1 1 0 1 1 1 1 Potato inhibitor I family ERbeta_N PF12497.3 EFE43644.1 - 0.11 12.3 0.6 0.16 11.7 0.4 1.2 1 0 0 1 1 1 0 Estrogen receptor beta Nefa_Nip30_N PF10187.4 EFE43645.1 - 3.6e-27 94.5 10.1 3.6e-27 94.5 7.0 1.8 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF2075 PF09848.4 EFE43645.1 - 0.0094 14.9 1.3 0.012 14.6 0.9 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF2570 PF10828.3 EFE43645.1 - 0.16 11.6 4.0 0.17 11.4 2.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) CK_II_beta PF01214.13 EFE43647.1 - 4.3e-69 231.7 0.1 7.5e-69 230.9 0.1 1.4 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Nucleoplasmin PF03066.10 EFE43647.1 - 2.1 7.8 10.8 3.9 6.9 7.5 1.4 1 0 0 1 1 1 0 Nucleoplasmin E1-E2_ATPase PF00122.15 EFE43648.1 - 2e-46 157.8 4.3 3.4e-46 157.1 1.9 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 EFE43648.1 - 2.4e-24 86.9 0.3 4.3e-24 86.1 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFE43648.1 - 5e-13 49.6 0.0 1.3e-12 48.2 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 EFE43648.1 - 6.9e-09 35.7 0.0 2.2e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.7 EFE43648.1 - 0.0001 22.0 0.1 0.15 11.6 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase CoA_binding_2 PF13380.1 EFE43648.1 - 0.025 14.7 0.1 0.068 13.3 0.0 1.8 1 0 0 1 1 1 0 CoA binding domain Fungal_trans_2 PF11951.3 EFE43650.1 - 1.2e-51 175.5 9.2 1.6e-51 175.0 6.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE43650.1 - 5.5e-08 32.5 9.9 1.2e-07 31.5 6.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_3 PF07859.8 EFE43651.1 - 6.9e-07 29.0 0.4 2.6e-06 27.1 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE43651.1 - 0.00052 19.7 1.3 0.0014 18.3 0.9 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE43651.1 - 0.001 18.9 3.6 0.0018 18.2 2.5 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EFE43651.1 - 0.014 15.6 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Chlorophyllase2 PF12740.2 EFE43651.1 - 0.039 12.8 0.1 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF2974 PF11187.3 EFE43651.1 - 0.17 11.2 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF3089 PF11288.3 EFE43651.1 - 0.17 11.0 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) JAB PF01398.16 EFE43652.1 - 1.1e-05 25.1 0.1 0.00061 19.5 0.1 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Trypan_PARP PF05887.6 EFE43653.1 - 0.0005 19.9 20.6 0.0005 19.9 14.2 16.3 7 4 11 18 18 18 1 Procyclic acidic repetitive protein (PARP) TraG_N PF07916.6 EFE43653.1 - 5.3 5.3 0.1 8.3 4.7 0.0 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region HMG_box_2 PF09011.5 EFE43654.1 - 2.8e-06 27.6 3.2 2.8e-06 27.6 2.2 2.6 3 0 0 3 3 3 1 HMG-box domain HMG_box PF00505.14 EFE43654.1 - 2.8e-06 27.5 4.4 2.8e-06 27.5 3.0 2.8 4 1 0 4 4 4 1 HMG (high mobility group) box DUF1074 PF06382.6 EFE43654.1 - 0.0092 15.9 0.8 0.0092 15.9 0.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1074) DUF4662 PF15578.1 EFE43654.1 - 0.025 14.1 9.5 0.033 13.7 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4662) Ndc1_Nup PF09531.5 EFE43654.1 - 6.8 4.9 6.2 10 4.3 4.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DEAD PF00270.24 EFE43655.1 - 5.7e-45 152.8 0.0 1.2e-44 151.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE43655.1 - 2.4e-24 84.9 0.0 7.3e-24 83.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFE43655.1 - 0.00035 19.4 0.0 0.00059 18.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EFE43655.1 - 0.015 15.1 0.0 0.14 11.9 0.0 2.6 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit EB_dh PF09459.5 EFE43656.1 - 0.042 13.2 1.4 0.97 8.8 0.1 2.2 2 0 0 2 2 2 0 Ethylbenzene dehydrogenase zf-C2H2_4 PF13894.1 EFE43656.1 - 4.5 7.8 17.0 2.3 8.7 0.0 4.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 EFE43658.1 - 9.5e-08 31.8 10.4 2.3e-05 24.3 1.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE43658.1 - 2.1e-06 27.7 12.3 2.8e-05 24.2 2.4 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFE43658.1 - 7.8e-06 25.9 3.1 7.8e-06 25.9 2.1 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.2 EFE43658.1 - 0.0017 18.5 1.0 0.0017 18.5 0.7 3.5 4 0 0 4 4 4 2 Zinc-finger of C2H2 type DUF2225 PF09986.4 EFE43658.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_jaz PF12171.3 EFE43658.1 - 0.028 14.5 1.3 0.028 14.5 0.9 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFE43658.1 - 1.3 9.0 4.6 0.53 10.2 0.9 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 EFE43658.1 - 3.5 7.8 9.9 0.6 10.2 4.1 1.8 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding IMD PF08397.6 EFE43659.1 - 0.077 12.2 2.1 0.088 12.1 1.5 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain SKG6 PF08693.5 EFE43660.1 - 0.045 13.0 1.7 0.086 12.1 1.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Rifin_STEVOR PF02009.11 EFE43660.1 - 0.22 11.1 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 Rifin/stevor family HAT PF02184.11 EFE43661.1 - 6.1e-24 83.4 79.7 1.7e-16 59.6 1.8 13.0 14 0 0 14 14 14 4 HAT (Half-A-TPR) repeat TPR_19 PF14559.1 EFE43661.1 - 8e-19 67.7 0.2 0.0002 21.5 0.0 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFE43661.1 - 1.7e-18 65.4 21.5 0.0033 17.9 0.2 11.5 6 2 8 14 14 13 5 Tetratricopeptide repeat TPR_16 PF13432.1 EFE43661.1 - 3.2e-14 53.1 14.7 0.17 12.6 0.0 8.5 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_11 PF13414.1 EFE43661.1 - 7.3e-09 35.1 4.3 0.0032 17.0 0.0 5.8 6 0 0 6 6 6 3 TPR repeat Suf PF05843.9 EFE43661.1 - 4.6e-08 33.1 24.6 0.00012 21.9 0.7 5.3 2 2 1 4 4 4 3 Suppressor of forked protein (Suf) TPR_17 PF13431.1 EFE43661.1 - 7.1e-07 28.9 0.2 2.9 8.3 0.0 5.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFE43661.1 - 0.00014 21.5 17.6 0.27 11.2 0.0 7.7 11 0 0 11 11 10 2 Tetratricopeptide repeat U3_assoc_6 PF08640.6 EFE43661.1 - 0.0019 17.9 30.7 0.021 14.5 2.1 6.8 5 3 2 7 7 7 2 U3 small nucleolar RNA-associated protein 6 TPR_6 PF13174.1 EFE43661.1 - 0.0023 18.2 19.4 0.7 10.4 0.0 7.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFE43661.1 - 0.013 15.2 9.8 11 6.0 0.0 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFE43661.1 - 0.32 10.9 25.2 7.6 6.5 0.0 8.2 7 3 4 11 11 11 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EFE43661.1 - 0.44 10.4 8.9 4.4 7.2 0.3 5.2 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat c-SKI_SMAD_bind PF08782.5 EFE43661.1 - 4.5 7.4 8.1 3.5 7.7 0.0 4.0 4 0 0 4 4 4 0 c-SKI Smad4 binding domain Prp31_C PF09785.4 EFE43662.1 - 9.4e-46 155.2 0.7 1.7e-45 154.4 0.5 1.4 1 0 0 1 1 1 1 Prp31 C terminal domain Nop PF01798.13 EFE43662.1 - 1.7e-40 137.7 0.0 3.8e-40 136.6 0.0 1.6 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EFE43662.1 - 1.2e-21 76.2 0.1 2.3e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain eIF-3c_N PF05470.7 EFE43662.1 - 0.056 11.5 0.2 0.075 11.1 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus ATP-synt_8 PF00895.15 EFE43663.1 - 0.32 11.2 4.5 0.48 10.6 3.1 1.2 1 0 0 1 1 1 0 ATP synthase protein 8 AdoHcyase PF05221.12 EFE43664.1 - 3e-123 410.0 0.1 3.4e-123 409.8 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 EFE43664.1 - 7.1e-85 282.8 2.2 1.4e-84 281.8 1.5 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 EFE43664.1 - 2.5e-07 30.0 0.1 5e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 EFE43664.1 - 0.00012 21.4 0.2 0.0002 20.7 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 EFE43664.1 - 0.00076 19.4 0.2 0.0018 18.2 0.1 1.7 1 1 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.16 EFE43664.1 - 0.014 14.9 0.1 0.025 14.1 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TMEM107 PF14995.1 EFE43664.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein DUF3759 PF12585.3 EFE43665.1 - 8.9e-38 128.0 6.5 1e-37 127.8 4.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) Band_7 PF01145.20 EFE43667.1 - 6.3e-27 94.6 0.3 6.3e-27 94.6 0.2 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family RecX PF02631.11 EFE43667.1 - 0.0054 16.9 1.8 0.013 15.6 0.3 2.2 1 1 1 2 2 2 1 RecX family Band_7_1 PF13421.1 EFE43667.1 - 0.013 14.9 0.0 0.034 13.6 0.0 1.6 1 1 0 1 1 1 0 SPFH domain-Band 7 family DNase_NucA_NucB PF14040.1 EFE43669.1 - 0.0043 17.1 3.5 1.1 9.4 0.3 3.5 1 1 1 3 3 3 2 Deoxyribonuclease NucA/NucB PAP2 PF01569.16 EFE43671.1 - 2.9e-22 78.7 0.8 6.2e-22 77.6 0.6 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.1 EFE43671.1 - 0.011 15.3 0.3 0.28 10.6 0.0 2.3 2 0 0 2 2 2 0 PAP2 superfamily DUF2370 PF10176.4 EFE43671.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Peptidase_C13 PF01650.13 EFE43673.1 - 0.0023 17.3 0.1 0.0032 16.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family Raptor_N PF14538.1 EFE43673.1 - 0.052 13.3 0.2 0.15 11.8 0.1 1.7 1 1 0 1 1 1 0 Raptor N-terminal CASPase like domain Aldo_ket_red PF00248.16 EFE43674.1 - 1.7e-54 184.6 0.1 1.9e-54 184.4 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Reo_sigmaC PF04582.7 EFE43675.1 - 0.05 12.7 0.1 0.064 12.4 0.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein NPR3 PF03666.8 EFE43677.1 - 1.7e-144 481.7 1.8 5.9e-143 476.6 0.0 2.7 3 0 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.6 EFE43677.1 - 0.0021 16.8 0.0 0.0046 15.7 0.0 1.5 1 0 0 1 1 1 1 Nitrogen permease regulator 2 SDA1 PF05285.7 EFE43677.1 - 6 6.0 40.6 0.076 12.2 5.3 3.2 3 0 0 3 3 3 0 SDA1 DUF1754 PF08555.5 EFE43678.1 - 0.027 15.0 19.8 0.031 14.8 13.7 1.1 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) SR-25 PF10500.4 EFE43678.1 - 0.93 8.9 17.2 1 8.7 11.9 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FCP1_C PF09309.5 EFE43678.1 - 1 8.6 19.0 1.1 8.4 13.2 1.0 1 0 0 1 1 1 0 FCP1, C-terminal DUF2149 PF09919.4 EFE43678.1 - 2 8.5 3.9 2.3 8.3 2.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) FYDLN_acid PF09538.5 EFE43678.1 - 4.4 7.9 16.6 6.3 7.4 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Pox_Ag35 PF03286.9 EFE43678.1 - 4.6 6.7 18.3 6.4 6.2 12.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein OmpH PF03938.9 EFE43678.1 - 4.8 7.0 10.4 5.8 6.8 7.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TFIIA PF03153.8 EFE43678.1 - 6 6.6 14.3 6.7 6.4 9.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rtf2 PF04641.7 EFE43678.1 - 7.1 5.7 15.3 8.2 5.5 10.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger RNA_pol_3_Rpc31 PF11705.3 EFE43678.1 - 7.9 6.3 23.1 10 5.9 16.0 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Methyltransf_25 PF13649.1 EFE43680.1 - 7.9e-12 45.4 0.0 1.5e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE43680.1 - 9.2e-10 39.0 0.0 1.6e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE43680.1 - 7.3e-09 35.3 0.0 1.9e-08 34.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE43680.1 - 1.1e-07 32.1 0.1 1.4e-06 28.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE43680.1 - 1.3e-05 24.9 0.0 5.4e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE43680.1 - 6.6e-05 22.9 0.0 0.00017 21.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE43680.1 - 9.8e-05 22.7 0.0 0.0003 21.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE43680.1 - 0.00098 18.3 0.0 0.0019 17.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EFE43680.1 - 0.0032 16.5 0.0 0.0067 15.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.1 EFE43680.1 - 0.0084 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 EFE43680.1 - 0.029 13.9 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DREV PF05219.7 EFE43680.1 - 0.12 11.1 0.0 0.25 10.2 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase PCMT PF01135.14 EFE43680.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) HemY_N PF07219.8 EFE43682.1 - 0.0015 18.1 0.2 0.27 10.7 0.1 2.7 2 1 1 3 3 3 2 HemY protein N-terminus EAV_GS PF01309.13 EFE43682.1 - 0.05 13.1 0.1 0.084 12.3 0.1 1.3 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein SpoIIIAC PF06686.6 EFE43682.1 - 0.13 12.0 2.4 0.24 11.2 0.1 2.3 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family DUF1992 PF09350.5 EFE43683.1 - 6.3e-20 70.7 0.3 2.3e-19 68.9 0.2 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) RPAP1_N PF08621.5 EFE43683.1 - 0.16 11.5 2.2 3.4 7.3 0.0 3.1 3 0 0 3 3 3 0 RPAP1-like, N-terminal p450 PF00067.17 EFE43684.1 - 2.4e-46 158.2 0.0 1.3e-45 155.8 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.2 EFE43685.1 - 1.7e-06 27.6 0.6 4.3e-06 26.3 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE43685.1 - 3e-05 23.5 0.1 7.3e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain Lactonase PF10282.4 EFE43685.1 - 0.044 12.8 0.0 0.12 11.4 0.0 1.5 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller SRP40_C PF05022.7 EFE43686.1 - 2.1e-22 79.3 0.1 5.6e-22 78.0 0.1 1.7 1 0 0 1 1 1 1 SRP40, C-terminal domain LisH PF08513.6 EFE43686.1 - 0.0096 15.6 1.0 0.18 11.5 0.1 2.5 2 0 0 2 2 2 1 LisH Sec3-PIP2_bind PF15277.1 EFE43687.1 - 5.8e-31 106.2 0.2 1.1e-30 105.2 0.1 1.5 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C PF09763.4 EFE43687.1 - 1.1e-24 86.6 0.5 1.9e-24 85.8 0.3 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec3 DOCK-C2 PF14429.1 EFE43688.1 - 6.4e-39 133.4 0.0 3.8e-38 130.9 0.0 2.3 3 0 0 3 3 3 1 C2 domain in Dock180 and Zizimin proteins Ded_cyto PF06920.8 EFE43688.1 - 1.8e-14 53.4 0.0 4.7e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 Dedicator of cytokinesis SH3_1 PF00018.23 EFE43688.1 - 2.4e-05 23.6 0.0 6.1e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFE43688.1 - 0.00044 19.7 0.1 0.0047 16.4 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Glyco_hydro_20 PF00728.17 EFE43689.1 - 1.7e-95 320.1 0.0 2.1e-95 319.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 EFE43689.1 - 2.9e-20 73.2 0.0 3.2e-19 69.8 0.0 2.2 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.10 EFE43689.1 - 2.9e-05 24.5 0.0 6.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Hen1_L PF12623.2 EFE43689.1 - 0.056 12.2 0.4 0.16 10.6 0.3 1.7 2 0 0 2 2 2 0 RNA repair, ligase-Pnkp-associating, region of Hen1 NmrA PF05368.8 EFE43690.1 - 7.3e-18 64.6 0.0 1.4e-10 40.8 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family adh_short PF00106.20 EFE43690.1 - 0.068 13.0 0.2 0.15 11.9 0.0 1.6 2 0 0 2 2 2 0 short chain dehydrogenase NAD_binding_10 PF13460.1 EFE43690.1 - 0.14 12.1 1.0 0.44 10.5 0.7 1.7 1 1 0 1 1 1 0 NADH(P)-binding Rrn6 PF10214.4 EFE43691.1 - 1.4 6.9 9.3 1.7 6.6 6.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Spore_coat_CotO PF14153.1 EFE43692.1 - 0.0021 17.5 5.1 0.0021 17.5 3.5 1.1 1 0 0 1 1 1 1 Spore coat protein CotO BUD22 PF09073.5 EFE43692.1 - 0.012 14.7 7.0 0.01 14.9 4.8 1.0 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.3 EFE43692.1 - 0.034 12.7 1.8 0.032 12.8 1.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2413 PF10310.4 EFE43692.1 - 0.044 12.6 6.9 0.049 12.4 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) IPK PF03770.11 EFE43692.1 - 0.064 12.8 0.0 0.066 12.8 0.0 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase BSP_II PF05432.6 EFE43692.1 - 0.17 11.1 20.3 0.21 10.8 14.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Pox_Ag35 PF03286.9 EFE43692.1 - 0.28 10.7 9.3 0.3 10.5 6.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DDRGK PF09756.4 EFE43692.1 - 0.73 9.2 15.1 0.86 8.9 10.5 1.1 1 0 0 1 1 1 0 DDRGK domain PBP1_TM PF14812.1 EFE43692.1 - 1.2 9.4 10.8 1.9 8.8 7.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3306 PF11748.3 EFE43692.1 - 1.7 9.3 9.1 2.1 9.0 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) RRN3 PF05327.6 EFE43692.1 - 1.9 6.4 7.6 1.9 6.4 5.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.7 EFE43692.1 - 2.1 6.1 17.3 2.2 6.0 12.0 1.0 1 0 0 1 1 1 0 Nop14-like family Prothymosin PF03247.9 EFE43692.1 - 2.3 8.4 31.8 3.2 7.9 22.0 1.1 1 0 0 1 1 1 0 Prothymosin/parathymosin family Sigma70_ner PF04546.8 EFE43692.1 - 2.3 7.8 14.7 2.8 7.5 10.2 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region NARP1 PF12569.3 EFE43692.1 - 2.9 6.5 6.4 3 6.4 4.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM176 PF14851.1 EFE43692.1 - 3 7.5 10.7 4 7.1 7.4 1.2 1 0 0 1 1 1 0 FAM176 family TFIIF_alpha PF05793.7 EFE43692.1 - 3.6 5.8 19.5 3.7 5.8 13.5 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1510 PF07423.6 EFE43692.1 - 4.2 6.6 16.5 4.9 6.4 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Usp PF00582.21 EFE43692.1 - 4.5 7.4 6.0 6.3 6.9 4.1 1.2 1 0 0 1 1 1 0 Universal stress protein family Daxx PF03344.10 EFE43692.1 - 4.7 5.5 21.9 5.2 5.4 15.2 1.0 1 0 0 1 1 1 0 Daxx Family Paf1 PF03985.8 EFE43692.1 - 5.2 5.6 17.7 6.4 5.3 12.2 1.2 1 0 0 1 1 1 0 Paf1 Atrophin-1 PF03154.10 EFE43692.1 - 5.6 4.9 9.6 5.1 5.0 6.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family Pox_RNA_Pol_19 PF05320.7 EFE43692.1 - 6.8 6.4 11.7 8.7 6.0 8.1 1.1 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit NOA36 PF06524.7 EFE43692.1 - 6.9 5.8 10.5 8.1 5.5 7.3 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.4 EFE43692.1 - 8.4 4.9 15.8 8.7 4.9 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pkinase PF00069.20 EFE43694.1 - 1.2e-48 165.5 0.0 1.9e-46 158.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43694.1 - 7.1e-32 110.4 0.0 1e-30 106.6 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE43694.1 - 0.00044 19.3 0.0 0.00072 18.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EFE43694.1 - 0.0073 15.1 0.1 0.0073 15.1 0.1 1.8 2 0 0 2 2 2 1 Seadornavirus VP7 Pox_ser-thr_kin PF05445.6 EFE43694.1 - 0.053 12.3 0.0 0.081 11.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Mem_trans PF03547.13 EFE43695.1 - 4e-56 189.9 0.1 4.6e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Membrane transport protein Choline_kinase PF01633.15 EFE43696.1 - 4.3e-60 202.8 0.0 8.7e-60 201.8 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 EFE43696.1 - 8.5e-16 57.1 0.0 1.8e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.18 EFE43696.1 - 5e-07 29.7 0.3 5e-07 29.7 0.2 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Abhydrolase_2 PF02230.11 EFE43697.1 - 1.9e-23 83.0 0.0 6.3e-18 65.0 0.0 2.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EFE43697.1 - 3.3e-07 30.4 0.2 4e-06 26.8 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE43697.1 - 6.4e-06 25.9 0.0 9.9e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 EFE43697.1 - 9.4e-05 21.9 0.0 0.0002 20.9 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.16 EFE43697.1 - 0.0052 16.0 0.1 0.011 14.9 0.0 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase family Glyco_hydro_31 PF01055.21 EFE43698.1 - 3.7e-155 517.0 0.0 8.5e-78 262.1 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 EFE43698.1 - 1.2e-10 41.1 0.2 4.5e-10 39.2 0.1 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like DUF1470 PF07336.6 EFE43699.1 - 0.016 15.5 1.6 0.29 11.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1470) Radial_spoke PF04712.7 EFE43699.1 - 0.018 13.8 0.5 0.026 13.2 0.4 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Myc_N PF01056.13 EFE43699.1 - 0.2 10.7 2.8 0.44 9.6 1.9 1.5 1 0 0 1 1 1 0 Myc amino-terminal region DNA_pol_phi PF04931.8 EFE43699.1 - 5.4 4.6 8.4 7.8 4.1 5.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Asp PF00026.18 EFE43700.1 - 6e-05 22.4 0.0 0.00011 21.5 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic aspartyl protease SKG6 PF08693.5 EFE43700.1 - 0.092 12.0 0.1 0.2 11.0 0.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain IncA PF04156.9 EFE43700.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 IncA protein MFS_1 PF07690.11 EFE43701.1 - 1.6e-18 66.5 39.2 2.8e-12 46.0 15.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE43701.1 - 2.4e-15 56.0 24.5 9.5e-15 54.1 17.0 2.4 1 1 0 1 1 1 1 Sugar (and other) transporter Glyco_hydro_92 PF07971.7 EFE43702.1 - 4e-138 461.1 0.1 5.6e-138 460.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 ATP-synt_G PF04718.10 EFE43704.1 - 3.8e-28 98.1 0.0 1.4e-27 96.3 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit DUF3813 PF12758.2 EFE43704.1 - 0.13 12.4 0.2 0.2 11.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) ADH_zinc_N PF00107.21 EFE43705.1 - 2.5e-17 62.6 0.0 4.8e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFE43705.1 - 5.4e-14 53.1 0.0 1.2e-13 52.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE43705.1 - 6.2e-09 35.5 0.0 3.3e-08 33.2 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_1 PF00561.15 EFE43706.1 - 3.9e-15 56.0 0.0 2.6e-14 53.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFE43706.1 - 3.8e-10 40.0 0.0 6.4e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE43706.1 - 0.012 15.3 0.0 0.059 13.1 0.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family PAP_central PF04928.12 EFE43707.1 - 4.5e-92 307.4 0.0 1.5e-69 233.6 0.0 3.1 2 1 0 2 2 2 2 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 EFE43707.1 - 2.9e-46 156.8 0.0 4.7e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 EFE43707.1 - 0.034 14.4 0.0 0.071 13.4 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain Nrap PF03813.9 EFE43707.1 - 0.1 10.0 0.0 0.17 9.3 0.0 1.2 1 0 0 1 1 1 0 Nrap protein Glyco_transf_20 PF00982.16 EFE43708.1 - 3.2e-164 546.8 0.0 8.7e-163 542.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.1 EFE43708.1 - 0.00028 21.0 0.0 0.00066 19.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 EFE43708.1 - 0.00076 18.9 0.2 0.0051 16.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 EFE43708.1 - 0.0066 15.9 0.3 0.011 15.2 0.2 1.4 1 0 0 1 1 1 1 Starch synthase catalytic domain adh_short PF00106.20 EFE43709.1 - 2.6e-26 92.5 2.4 4.3e-26 91.8 1.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE43709.1 - 1.9e-22 80.2 1.4 3.1e-22 79.5 1.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE43709.1 - 2.8e-12 46.6 0.7 4.4e-12 46.0 0.5 1.3 1 0 0 1 1 1 1 KR domain Poxvirus_B22R_C PF13168.1 EFE43709.1 - 0.034 13.4 0.1 0.072 12.3 0.0 1.6 2 0 0 2 2 2 0 Poxvirus B22R protein C-terminal DUF3391 PF11871.3 EFE43709.1 - 0.086 13.0 0.0 0.19 11.9 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) ACC_epsilon PF13822.1 EFE43709.1 - 0.11 12.8 0.2 0.53 10.6 0.0 2.1 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Amidase PF01425.16 EFE43710.1 - 7.7e-85 285.3 0.0 9.5e-85 285.0 0.0 1.0 1 0 0 1 1 1 1 Amidase Cation_efflux PF01545.16 EFE43711.1 - 9.8e-29 100.3 5.5 1.2e-28 100.0 3.8 1.1 1 0 0 1 1 1 1 Cation efflux family FlgN PF05130.7 EFE43711.1 - 0.055 13.7 1.6 0.14 12.4 1.1 1.6 1 0 0 1 1 1 0 FlgN protein Sulfotransfer_3 PF13469.1 EFE43712.1 - 0.00061 20.7 0.3 0.001 20.0 0.2 1.5 1 1 0 1 1 1 1 Sulfotransferase family Methyltransf_25 PF13649.1 EFE43713.1 - 3.5e-13 49.7 0.0 7.3e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE43713.1 - 1.2e-07 32.1 0.0 2.2e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE43713.1 - 2.3e-06 27.4 0.0 1.1e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE43713.1 - 4.5e-06 27.2 0.0 8.6e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE43713.1 - 7.5e-05 22.3 0.0 0.0002 20.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE43713.1 - 0.00015 21.7 0.0 0.00038 20.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE43713.1 - 0.00082 18.5 0.0 0.0016 17.5 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 EFE43713.1 - 0.0014 19.0 0.0 0.0071 16.8 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_20 PF12147.3 EFE43713.1 - 0.03 13.1 0.0 0.17 10.6 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase HNF-1B_C PF04812.8 EFE43713.1 - 0.09 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus 2_5_RNA_ligase2 PF13563.1 EFE43715.1 - 3.2e-32 111.3 0.0 6.3e-32 110.4 0.0 1.5 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.12 EFE43715.1 - 3.2e-23 81.8 0.0 6.2e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain Exo_endo_phos PF03372.18 EFE43715.1 - 7.7e-12 45.6 0.1 1.6e-11 44.6 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF504 PF04457.7 EFE43715.1 - 2.2e-11 43.7 0.2 6.1e-11 42.3 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF504) PAP_RNA-bind PF04926.10 EFE43715.1 - 6.7e-06 25.7 0.0 1.3e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 EFE43715.1 - 0.00021 21.5 0.0 0.001 19.3 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain RTC4 PF14474.1 EFE43715.1 - 0.12 12.3 0.0 3.6 7.5 0.0 2.5 2 0 0 2 2 2 0 RTC4-like domain Aminotran_1_2 PF00155.16 EFE43718.1 - 3.9e-15 55.6 0.0 8.8e-15 54.5 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Pectate_lyase_3 PF12708.2 EFE43719.1 - 2.4e-89 299.3 14.5 4.6e-69 232.9 6.7 2.5 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.3 EFE43719.1 - 7.3e-06 25.3 6.3 0.0015 17.9 0.1 2.9 3 0 0 3 3 3 2 N terminal extension of bacteriophage endosialidase SF3b1 PF08920.5 EFE43721.1 - 0.069 13.1 2.0 0.12 12.4 1.4 1.3 1 0 0 1 1 1 0 Splicing factor 3B subunit 1 MRP-S32 PF10210.4 EFE43721.1 - 0.11 12.8 1.1 0.77 10.1 0.0 2.3 1 1 2 3 3 3 0 Mitochondrial 28S ribosomal protein S32 Fungal_trans_2 PF11951.3 EFE43722.1 - 1.9e-08 33.3 0.0 8.1e-06 24.6 0.1 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain DUF2217 PF10265.4 EFE43724.1 - 0.03 13.0 1.7 0.037 12.8 1.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Pyr_redox_2 PF07992.9 EFE43725.1 - 1e-25 90.8 0.0 1.6e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE43725.1 - 1.3e-12 47.8 0.0 4.7e-10 39.7 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE43725.1 - 0.0027 17.7 0.1 0.097 12.7 0.0 2.9 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFE43725.1 - 0.008 15.9 0.3 0.11 12.3 0.0 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding GAT PF03127.9 EFE43726.1 - 9.6e-15 54.3 0.2 3.9e-14 52.4 0.0 1.9 2 0 0 2 2 2 1 GAT domain VHS PF00790.14 EFE43726.1 - 0.15 11.7 0.3 0.48 10.0 0.0 2.0 3 0 0 3 3 3 0 VHS domain Ferric_reduct PF01794.14 EFE43727.1 - 1.3e-23 83.4 9.2 1.3e-23 83.4 6.4 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EFE43727.1 - 3.7e-16 59.4 0.1 1e-13 51.4 0.0 2.7 2 1 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFE43727.1 - 4.1e-13 49.1 0.0 5.3e-07 29.4 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.16 EFE43727.1 - 0.13 12.8 0.0 0.68 10.5 0.0 2.2 2 1 0 2 2 2 0 Oxidoreductase NAD-binding domain DUF2374 PF09574.5 EFE43727.1 - 0.49 10.0 5.3 0.61 9.7 1.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) Cyt-b5 PF00173.23 EFE43728.1 - 1.7e-07 30.9 0.0 2.6e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ribosomal_S25 PF03297.10 EFE43729.1 - 6e-27 93.7 1.3 7.2e-27 93.4 0.9 1.0 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.14 EFE43729.1 - 0.00059 19.4 0.2 0.00071 19.2 0.1 1.1 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_DeoR PF08220.7 EFE43729.1 - 0.0029 17.1 0.1 0.0042 16.5 0.1 1.3 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.15 EFE43729.1 - 0.014 15.4 0.1 0.022 14.8 0.1 1.4 1 1 0 1 1 1 0 Transcriptional regulator MarR_2 PF12802.2 EFE43729.1 - 0.02 14.5 0.1 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.7 EFE43729.1 - 0.022 14.3 0.1 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 HTH domain FeoC PF09012.5 EFE43729.1 - 0.061 13.0 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_24 PF13412.1 EFE43729.1 - 0.081 12.3 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding WD40 PF00400.27 EFE43730.1 - 1.7e-07 30.8 4.7 0.00045 20.0 0.1 5.5 7 0 0 7 7 7 2 WD domain, G-beta repeat IKI3 PF04762.7 EFE43730.1 - 3e-06 25.3 0.0 6.4e-06 24.2 0.0 1.5 1 1 0 1 1 1 1 IKI3 family eIF2A PF08662.6 EFE43730.1 - 3.4e-05 23.6 0.5 0.13 11.9 0.0 3.3 3 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A 2OG-FeII_Oxy_3 PF13640.1 EFE43731.1 - 0.00054 20.4 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ABC_tran PF00005.22 EFE43732.1 - 9.8e-43 145.7 4.4 6.8e-22 78.2 0.0 3.7 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 EFE43732.1 - 9.8e-19 68.3 2.5 0.00087 19.3 0.0 4.2 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 EFE43732.1 - 8.3e-10 38.2 1.9 0.013 14.7 0.4 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_tran_2 PF12848.2 EFE43732.1 - 1.5e-07 31.1 2.1 1.5e-07 31.1 1.5 2.2 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.1 EFE43732.1 - 1.6e-06 27.5 0.4 0.0047 16.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 EFE43732.1 - 1.4e-05 25.5 0.3 0.19 12.2 0.0 3.2 2 1 0 2 2 2 2 Miro-like protein AAA_17 PF13207.1 EFE43732.1 - 5.1e-05 24.0 0.6 0.13 13.1 0.0 3.1 3 0 0 3 3 2 1 AAA domain MMR_HSR1 PF01926.18 EFE43732.1 - 5.3e-05 23.1 2.9 0.3 11.0 0.0 3.5 4 0 0 4 4 3 2 50S ribosome-binding GTPase AAA_23 PF13476.1 EFE43732.1 - 9.7e-05 22.7 11.4 0.0011 19.3 0.6 3.2 3 1 0 3 3 3 2 AAA domain AAA_22 PF13401.1 EFE43732.1 - 0.00015 21.8 0.4 0.13 12.4 0.0 3.2 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFE43732.1 - 0.00034 19.8 0.3 0.37 9.9 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 NACHT PF05729.7 EFE43732.1 - 0.00043 19.9 0.2 0.69 9.5 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.1 EFE43732.1 - 0.00097 19.1 1.4 0.47 10.4 0.3 3.4 2 1 0 2 2 2 1 AAA domain MobB PF03205.9 EFE43732.1 - 0.0012 18.5 0.8 0.22 11.1 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 EFE43732.1 - 0.004 17.4 0.2 3.7 7.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EFE43732.1 - 0.0042 16.9 0.2 4.1 7.3 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA PF00004.24 EFE43732.1 - 0.0057 16.8 0.1 1.2 9.2 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EFE43732.1 - 0.0061 15.9 0.1 0.82 9.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EFE43732.1 - 0.01 14.6 0.8 1.9 7.1 0.1 2.6 2 0 0 2 2 2 0 ArgK protein RNA_helicase PF00910.17 EFE43732.1 - 0.015 15.4 0.0 3.4 7.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase Arch_ATPase PF01637.13 EFE43732.1 - 0.016 14.9 0.1 6.1 6.4 0.0 2.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_33 PF13671.1 EFE43732.1 - 0.028 14.3 3.7 3.2 7.6 0.1 3.3 3 1 0 3 3 3 0 AAA domain AAA_5 PF07728.9 EFE43732.1 - 0.034 13.8 1.1 0.9 9.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 EFE43732.1 - 0.047 13.2 0.1 3.5 7.0 0.0 3.4 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 EFE43732.1 - 0.054 13.4 14.9 0.27 11.2 4.7 3.3 2 2 0 2 2 2 0 AAA ATPase domain cobW PF02492.14 EFE43732.1 - 0.062 12.7 1.5 1.7 8.0 0.0 2.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.12 EFE43732.1 - 0.063 13.0 13.8 2.2 8.0 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function DUF87 AAA_15 PF13175.1 EFE43732.1 - 0.096 11.7 4.5 4 6.3 0.0 3.5 4 0 0 4 4 4 0 AAA ATPase domain AAA_10 PF12846.2 EFE43732.1 - 0.18 11.2 4.8 5.5 6.3 0.2 3.0 2 1 0 2 2 2 0 AAA-like domain Dynamin_N PF00350.18 EFE43732.1 - 0.19 11.5 3.9 7.7 6.3 0.3 3.3 3 1 0 3 3 3 0 Dynamin family AA_permease PF00324.16 EFE43733.1 - 3.1e-134 447.8 37.4 3.1e-134 447.8 25.9 1.4 2 0 0 2 2 2 1 Amino acid permease AA_permease_2 PF13520.1 EFE43733.1 - 1.2e-33 116.2 38.5 1.6e-33 115.8 26.7 1.1 1 0 0 1 1 1 1 Amino acid permease MoaC PF01967.16 EFE43734.1 - 5.4e-41 139.4 0.1 1e-40 138.5 0.1 1.5 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.8 EFE43734.1 - 4.5e-35 120.1 0.0 2.2e-34 117.9 0.0 2.0 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.16 EFE43734.1 - 3.1e-23 82.7 0.1 6e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 EFE43734.1 - 0.00028 21.0 0.0 0.00062 19.8 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 EFE43734.1 - 0.00077 19.4 0.0 0.0021 18.0 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Piwi PF02171.12 EFE43735.1 - 1.6e-39 135.6 0.0 2.7e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Piwi domain DUF1785 PF08699.5 EFE43735.1 - 4.7e-16 57.8 0.0 1.1e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) PAZ PF02170.17 EFE43735.1 - 1.6e-12 46.8 0.0 1.6e-12 46.8 0.0 2.7 3 0 0 3 3 3 1 PAZ domain Noc2 PF03715.8 EFE43736.1 - 1.8e-121 404.6 0.0 1.8e-121 404.6 0.0 1.8 2 0 0 2 2 2 1 Noc2p family VPS28 PF03997.7 EFE43737.1 - 1.8e-60 203.8 0.4 2.1e-60 203.5 0.3 1.1 1 0 0 1 1 1 1 VPS28 protein GvpG PF05120.7 EFE43737.1 - 0.6 9.9 3.2 0.9 9.3 0.5 2.1 2 0 0 2 2 2 0 Gas vesicle protein G Fungal_trans_2 PF11951.3 EFE43738.1 - 8.9e-08 31.1 0.6 3.3e-06 25.9 0.1 2.4 2 1 0 2 2 2 2 Fungal specific transcription factor domain APH PF01636.18 EFE43739.1 - 3.2e-18 66.3 0.0 4e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFE43739.1 - 0.00053 19.3 0.0 0.59 9.4 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Kdo PF06293.9 EFE43739.1 - 0.0047 16.0 0.0 0.2 10.6 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE43739.1 - 0.0062 16.1 0.0 0.01 15.4 0.0 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.20 EFE43739.1 - 0.01 15.0 0.0 1.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Protein kinase domain Fructosamin_kin PF03881.9 EFE43739.1 - 0.099 11.6 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase Methyltransf_16 PF10294.4 EFE43740.1 - 2.2e-23 82.5 0.0 3e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 EFE43740.1 - 0.0021 17.7 0.0 0.0044 16.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 EFE43740.1 - 0.057 12.7 0.0 0.075 12.4 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_18 PF12847.2 EFE43740.1 - 0.058 13.9 0.0 0.1 13.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EFE43740.1 - 0.073 12.4 0.1 0.18 11.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain ABC_membrane PF00664.18 EFE43741.1 - 1.9e-35 122.6 31.8 4.8e-29 101.6 10.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE43741.1 - 3.3e-31 108.4 0.0 3e-18 66.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFE43741.1 - 2.8e-16 60.3 0.9 2.1e-05 24.6 0.0 3.9 3 1 0 4 4 4 3 AAA domain SMC_N PF02463.14 EFE43741.1 - 1.1e-11 44.4 0.0 3.2e-05 23.2 0.0 3.2 2 1 1 3 3 3 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 EFE43741.1 - 4.4e-05 22.2 1.5 2.1 6.8 0.0 3.9 3 1 0 3 3 3 2 Predicted ATPase of the ABC class DUF389 PF04087.9 EFE43741.1 - 0.0061 16.5 1.3 0.0061 16.5 0.9 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF389) AAA_29 PF13555.1 EFE43741.1 - 0.0061 16.0 0.0 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EFE43741.1 - 0.012 15.0 0.1 0.053 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 EFE43741.1 - 0.032 13.1 0.0 0.067 12.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 EFE43741.1 - 0.22 11.8 0.0 0.54 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Tannase PF07519.6 EFE43742.1 - 1.6e-66 224.9 0.0 2.7e-65 220.9 0.0 2.0 1 1 1 2 2 2 2 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 EFE43742.1 - 0.027 14.3 0.0 0.052 13.4 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family VWA PF00092.23 EFE43743.1 - 3.3e-10 39.9 0.0 5.7e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 EFE43743.1 - 1.6e-08 34.8 0.0 2.4e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 EFE43743.1 - 0.0014 18.4 0.0 0.002 17.9 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_3 PF13768.1 EFE43743.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain Vesiculo_matrix PF06326.7 EFE43743.1 - 0.31 10.4 1.3 2.7 7.3 1.1 1.9 2 0 0 2 2 2 0 Vesiculovirus matrix protein Apc4 PF12896.2 EFE43746.1 - 1.2e-62 210.9 0.9 1.8e-62 210.3 0.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 Apc4_WD40 PF12894.2 EFE43746.1 - 3.6e-16 58.4 0.0 9.6e-16 57.0 0.0 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT PF02985.17 EFE43747.1 - 9.2e-17 59.5 9.7 0.00019 21.2 0.0 9.1 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.1 EFE43747.1 - 4.1e-14 52.6 8.5 0.00013 22.1 0.0 6.1 3 2 2 6 6 6 4 HEAT repeats HEAT_EZ PF13513.1 EFE43747.1 - 2e-08 34.5 19.0 1.3e-05 25.5 0.0 8.3 8 2 3 11 11 11 2 HEAT-like repeat IBN_N PF03810.14 EFE43747.1 - 7.5e-08 32.1 0.6 6.8e-05 22.7 0.0 3.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain CLASP_N PF12348.3 EFE43747.1 - 1.1e-07 31.4 3.3 0.007 15.7 0.0 4.3 4 1 1 5 5 5 2 CLASP N terminal DUF3535 PF12054.3 EFE43747.1 - 0.00037 19.2 0.5 0.00081 18.1 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3535) Arm PF00514.18 EFE43747.1 - 0.0011 18.6 2.8 22 5.0 0.1 5.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat MMS19_N PF14500.1 EFE43747.1 - 0.0024 17.2 0.2 1.7 7.8 0.3 2.8 3 0 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II Metallophos PF00149.23 EFE43748.1 - 1.5e-08 34.3 1.5 3.5e-08 33.0 1.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE43748.1 - 1.5e-07 31.3 0.0 2.9e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ribosomal_S8 PF00410.14 EFE43749.1 - 4.7e-20 71.7 0.1 1.4e-19 70.1 0.1 1.7 1 1 0 1 1 1 1 Ribosomal protein S8 PS_Dcarbxylase PF02666.10 EFE43751.1 - 6.6e-81 270.4 0.0 1.3e-80 269.4 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Cation_ATPase_N PF00690.21 EFE43752.1 - 1.5e-14 53.2 0.0 1.7e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus E1-E2_ATPase PF00122.15 EFE43753.1 - 1.7e-64 217.0 2.5 2.8e-64 216.3 1.7 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE43753.1 - 1.2e-33 116.2 14.8 1.5e-33 115.8 5.4 2.5 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE43753.1 - 2.6e-31 109.7 0.0 2.7e-29 103.1 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE43753.1 - 1.5e-16 60.1 0.0 3e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE43753.1 - 4.1e-12 46.6 0.0 1.1e-11 45.2 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE43753.1 - 1.4e-05 24.7 0.5 0.0022 17.6 0.4 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF2463 PF09591.5 EFE43753.1 - 0.0081 15.7 0.8 0.015 14.8 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) COG4 PF08318.7 EFE43754.1 - 7.8e-68 228.6 0.0 1e-67 228.2 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein UPF0184 PF03670.8 EFE43754.1 - 0.12 12.6 0.2 1.5 9.0 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) SIR2 PF02146.12 EFE43755.1 - 1e-56 191.4 0.0 1.5e-56 190.9 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Hexokinase_2 PF03727.11 EFE43756.1 - 2.1e-85 285.8 0.0 3e-85 285.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 EFE43756.1 - 3.5e-75 251.8 0.0 4.7e-75 251.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase WD40 PF00400.27 EFE43757.1 - 3.8e-06 26.5 1.8 1.3 9.0 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat SGL PF08450.7 EFE43757.1 - 0.0076 15.6 0.1 0.33 10.2 0.0 2.2 1 1 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region Nucleoporin_N PF08801.6 EFE43757.1 - 0.18 10.5 0.0 0.3 9.7 0.0 1.3 1 0 0 1 1 1 0 Nup133 N terminal like DUF3661 PF12400.3 EFE43758.1 - 8.2e-35 119.7 8.0 1.5e-34 118.8 5.6 1.5 1 0 0 1 1 1 1 Vaculolar membrane protein Glycophorin_A PF01102.13 EFE43758.1 - 0.067 12.9 0.9 1 9.1 0.6 2.3 2 0 0 2 2 2 0 Glycophorin A TMEM154 PF15102.1 EFE43758.1 - 0.08 12.6 0.4 0.51 10.0 0.3 2.2 2 0 0 2 2 2 0 TMEM154 protein family SSP160 PF06933.6 EFE43758.1 - 4.4 5.1 12.1 6.9 4.5 8.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.12 EFE43758.1 - 4.9 6.9 23.6 10 5.8 16.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein TLP-20 PF06088.6 EFE43759.1 - 0.33 10.6 3.2 0.4 10.3 2.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PBP_sp32 PF07222.7 EFE43759.1 - 0.72 8.9 7.9 0.83 8.7 5.5 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF1510 PF07423.6 EFE43759.1 - 0.78 9.0 11.0 0.81 9.0 7.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) U79_P34 PF03064.11 EFE43759.1 - 1.6 8.1 15.2 1.8 8.0 10.6 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 CDC45 PF02724.9 EFE43759.1 - 3.2 5.6 10.0 3.1 5.7 7.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Ammonium_transp PF00909.16 EFE43760.1 - 2.3e-114 381.9 28.8 2.7e-114 381.7 20.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family E1-E2_ATPase PF00122.15 EFE43761.1 - 6.6e-79 264.1 0.2 1.3e-78 263.2 0.1 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE43761.1 - 4.2e-44 150.2 0.2 4.2e-44 150.2 0.1 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE43761.1 - 3.5e-31 109.2 0.0 3.6e-30 106.0 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFE43761.1 - 8.2e-23 79.6 0.0 1.8e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 EFE43761.1 - 1.9e-16 60.8 0.0 5.4e-16 59.3 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE43761.1 - 1.5e-13 50.4 0.0 3.2e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFE43761.1 - 8.8e-06 25.4 1.5 0.00018 21.2 0.7 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rad21_Rec8_N PF04825.8 EFE43762.1 - 3.4e-39 133.2 0.0 5.3e-39 132.6 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 EFE43762.1 - 8.8e-07 28.0 0.2 1.8e-06 27.0 0.2 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 EFE43762.1 - 0.004 16.7 0.0 0.011 15.2 0.0 1.7 2 0 0 2 2 2 1 ScpA/B protein Zn_clus PF00172.13 EFE43765.1 - 0.003 17.4 9.0 0.003 17.4 6.3 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.19 EFE43765.1 - 0.032 13.9 0.0 0.069 12.9 0.0 1.5 1 0 0 1 1 1 0 PAS fold Flavokinase PF01687.12 EFE43766.1 - 1.5e-28 99.1 0.0 1.7e-27 95.7 0.0 2.2 1 1 0 1 1 1 1 Riboflavin kinase DUF221 PF02714.10 EFE43767.1 - 4.9e-109 364.1 27.1 4.9e-109 364.1 18.8 2.0 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFE43767.1 - 3e-45 153.5 1.0 3e-45 153.5 0.7 3.3 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EFE43767.1 - 2.6e-14 52.8 0.6 6e-14 51.6 0.0 1.9 2 0 0 2 2 2 1 Phosphate metabolism protein DUF4463 PF14703.1 EFE43767.1 - 3.6e-10 40.2 3.5 0.00067 20.1 0.8 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4463) AAA_13 PF13166.1 EFE43767.1 - 0.013 13.9 0.3 0.023 13.1 0.2 1.3 1 0 0 1 1 1 0 AAA domain SnoaL_2 PF12680.2 EFE43768.1 - 1.6e-06 28.4 0.0 2.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.7 EFE43768.1 - 0.0001 21.8 0.0 0.0002 20.9 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DLH PF01738.13 EFE43768.1 - 0.03 13.6 0.0 0.88 8.8 0.0 2.6 2 1 1 3 3 3 0 Dienelactone hydrolase family Indigoidine_A PF04227.7 EFE43769.1 - 9.3e-57 192.4 4.8 6.7e-48 163.4 0.0 2.2 1 1 1 2 2 2 2 Indigoidine synthase A like protein PfkB PF00294.19 EFE43769.1 - 1.3e-10 40.8 0.0 1.9e-05 23.9 0.0 2.9 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Ribophorin_I PF04597.9 EFE43770.1 - 2e-138 461.5 0.1 2.3e-138 461.3 0.1 1.0 1 0 0 1 1 1 1 Ribophorin I Ribosomal_L23eN PF03939.8 EFE43770.1 - 0.03 14.3 0.6 0.085 12.9 0.4 1.7 1 0 0 1 1 1 0 Ribosomal protein L23, N-terminal domain VTC PF09359.5 EFE43771.1 - 1.4e-100 335.9 0.4 2.1e-100 335.3 0.3 1.3 1 0 0 1 1 1 1 VTC domain SPX PF03105.14 EFE43771.1 - 2.7e-27 96.2 3.5 7.2e-14 52.2 0.7 3.2 1 1 1 2 2 2 2 SPX domain DUF202 PF02656.10 EFE43771.1 - 1e-09 38.4 4.2 2.2e-09 37.3 2.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) MCM PF00493.18 EFE43772.1 - 5.6e-140 465.8 0.0 7.3e-140 465.4 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EFE43772.1 - 4.9e-25 88.3 0.0 2.6e-24 86.0 0.0 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 EFE43772.1 - 6.6e-06 25.4 0.0 0.00025 20.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFE43772.1 - 2.2e-05 24.2 0.2 0.00012 21.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EFE43772.1 - 0.0028 17.2 0.0 0.013 15.1 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_32 PF13654.1 EFE43772.1 - 0.082 11.5 5.6 0.038 12.6 0.3 2.2 2 0 0 2 2 2 0 AAA domain Utp21 PF04192.7 EFE43772.1 - 0.11 11.5 0.4 0.32 10.0 0.0 1.9 2 0 0 2 2 2 0 Utp21 specific WD40 associated putative domain Ank_2 PF12796.2 EFE43773.1 - 4.6e-08 33.2 0.1 4.6e-06 26.8 0.1 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE43773.1 - 0.037 14.5 0.0 8.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Band_7 PF01145.20 EFE43774.1 - 3.1e-13 50.0 7.2 4.9e-13 49.3 4.7 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family Methyltransf_5 PF01795.14 EFE43774.1 - 0.11 11.8 2.8 0.14 11.3 2.0 1.3 1 1 0 1 1 1 0 MraW methylase family CSTF2_hinge PF14327.1 EFE43775.1 - 6e-30 103.1 2.5 6e-30 103.1 1.8 2.2 2 1 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.1 EFE43775.1 - 2.2e-17 62.0 7.2 2.2e-17 62.0 5.0 2.3 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.17 EFE43775.1 - 1.8e-15 56.2 0.1 4.3e-15 55.1 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE43775.1 - 3.9e-13 49.1 0.0 1.7e-12 47.1 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE43775.1 - 2.8e-07 30.2 0.0 4.5e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SWI-SNF_Ssr4 PF08549.5 EFE43775.1 - 0.22 9.7 11.2 0.34 9.1 7.8 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SNF2_N PF00176.18 EFE43776.1 - 2.1e-25 89.1 0.1 6.5e-15 54.7 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain DNA_methylase PF00145.12 EFE43776.1 - 6.4e-19 68.2 0.0 1.2e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Helicase_C PF00271.26 EFE43776.1 - 0.00047 19.9 0.0 0.0039 17.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.1 EFE43776.1 - 0.083 12.6 27.5 0.057 13.1 7.2 2.7 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFE43776.1 - 2.5 8.1 26.0 0.79 9.8 6.8 3.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) 2Fe-2S_thioredx PF01257.14 EFE43777.1 - 6.9e-59 197.6 0.1 8.8e-59 197.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin DUF4139 PF13598.1 EFE43778.1 - 5.1e-53 180.4 7.0 2.4e-38 132.2 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4139) DUF4140 PF13600.1 EFE43778.1 - 7.6e-11 42.3 11.9 1.9e-10 41.0 0.0 3.4 3 2 0 3 3 3 1 N-terminal domain of unknown function (DUF4140) YhzD PF14120.1 EFE43778.1 - 0.83 9.5 9.5 0.3 11.0 4.2 2.0 2 0 0 2 2 2 0 YhzD-like protein V_ATPase_I PF01496.14 EFE43778.1 - 2.4 5.9 5.7 3.4 5.4 3.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 EFE43778.1 - 9.6 5.1 10.8 17 4.3 7.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Sua5_yciO_yrdC PF01300.13 EFE43779.1 - 6.2e-54 181.9 0.0 9.9e-54 181.2 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 EFE43779.1 - 1.1e-25 90.1 0.0 1.9e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding DUF3441 PF11923.3 EFE43780.1 - 6e-34 116.0 0.0 2.8e-33 113.8 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3441) FbpA PF05833.6 EFE43780.1 - 8.2e-30 103.7 8.1 1.9e-29 102.5 5.6 1.5 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF814 PF05670.8 EFE43780.1 - 3.6e-16 58.8 0.0 9.7e-16 57.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Clat_adaptor_s PF01217.15 EFE43781.1 - 8.2e-14 51.5 0.0 1.8e-12 47.1 0.1 2.0 2 0 0 2 2 2 1 Clathrin adaptor complex small chain FAM91_N PF14647.1 EFE43781.1 - 0.12 11.3 0.1 0.18 10.8 0.1 1.2 1 0 0 1 1 1 0 FAM91 N-terminus TPR_MLP1_2 PF07926.7 EFE43783.1 - 0.00033 20.4 17.3 0.00033 20.4 12.0 3.0 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein DUF948 PF06103.6 EFE43783.1 - 0.0036 17.1 1.6 0.0077 16.0 1.1 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) DUF1515 PF07439.6 EFE43783.1 - 0.1 12.3 10.5 0.028 14.2 2.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Laminin_II PF06009.7 EFE43783.1 - 1.6 8.5 10.9 4.9 6.9 7.6 1.8 1 0 0 1 1 1 0 Laminin Domain II ERM PF00769.14 EFE43783.1 - 2.4 7.6 33.3 1.8 8.0 7.2 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF3573 PF12097.3 EFE43783.1 - 3.9 5.9 4.8 2.2 6.7 1.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) FlaC_arch PF05377.6 EFE43783.1 - 3.9 7.4 11.5 13 5.8 1.1 4.0 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) DUF3373 PF11853.3 EFE43783.1 - 5.6 5.3 10.3 0.72 8.3 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3373) Phage_GP20 PF06810.6 EFE43783.1 - 6.1 6.2 26.9 0.024 14.0 9.2 3.4 3 1 0 3 3 3 0 Phage minor structural protein GP20 V_ATPase_I PF01496.14 EFE43783.1 - 7.1 4.3 9.3 12 3.6 6.4 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HAUS6_N PF14661.1 EFE43783.1 - 9 5.5 16.2 35 3.6 10.8 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Pyridoxal_deC PF00282.14 EFE43784.1 - 5e-18 64.6 0.0 7e-10 37.8 0.0 3.2 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain Ribosomal_L16 PF00252.13 EFE43785.1 - 1.8e-27 95.7 0.0 2.7e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF3245 PF11595.3 EFE43785.1 - 0.41 10.8 2.0 0.68 10.1 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) APH PF01636.18 EFE43787.1 - 1.9e-08 34.3 0.0 2.2e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE43787.1 - 0.0028 17.2 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 EFE43787.1 - 0.035 12.7 0.0 0.045 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) EPTP PF03736.12 EFE43787.1 - 0.048 13.4 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 EPTP domain DUF1895 PF08988.5 EFE43787.1 - 0.071 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1895) FAD_binding_2 PF00890.19 EFE43788.1 - 8.3e-83 278.5 0.1 1e-82 278.2 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFE43788.1 - 3.2e-11 42.7 0.7 6.4e-07 28.5 0.2 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.2 EFE43788.1 - 9.6e-11 41.3 2.0 4.2e-09 35.9 0.6 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFE43788.1 - 3.2e-07 29.7 0.1 0.0017 17.4 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 EFE43788.1 - 6.5e-07 29.2 0.9 1.8e-06 27.8 0.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFE43788.1 - 1.6e-06 28.1 0.2 6.4e-06 26.1 0.0 2.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE43788.1 - 9.1e-06 24.3 1.4 1.5e-05 23.7 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.12 EFE43788.1 - 2.7e-05 23.3 0.3 5.9e-05 22.2 0.2 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 EFE43788.1 - 0.0024 17.9 0.2 0.0084 16.1 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UPF0227 PF05728.7 EFE43788.1 - 0.063 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) GIDA PF01134.17 EFE43788.1 - 0.14 11.0 0.7 0.23 10.2 0.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AAA PF00004.24 EFE43789.1 - 1.4e-19 70.6 0.0 4.9e-19 68.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFE43789.1 - 7.9e-05 23.4 0.3 0.0025 18.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 EFE43789.1 - 0.00017 21.8 0.9 0.0012 19.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 EFE43789.1 - 0.00021 21.3 0.2 0.00094 19.2 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EFE43789.1 - 0.00041 20.0 0.0 0.0011 18.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 EFE43789.1 - 0.00042 20.0 0.1 0.0008 19.1 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 EFE43789.1 - 0.0013 18.2 0.0 0.0025 17.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.1 EFE43789.1 - 0.0016 18.5 0.8 0.013 15.6 0.1 2.7 2 1 0 2 2 2 1 AAA domain Zot PF05707.7 EFE43789.1 - 0.0062 16.0 0.1 0.096 12.1 0.0 2.3 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) AAA_14 PF13173.1 EFE43789.1 - 0.0097 15.8 0.0 0.035 13.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.1 EFE43789.1 - 0.025 14.1 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFE43789.1 - 0.03 14.2 0.0 0.078 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFE43789.1 - 0.036 13.2 0.0 0.082 12.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 EFE43789.1 - 0.039 13.8 0.0 0.18 11.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EFE43789.1 - 0.081 12.7 0.0 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 EFE43789.1 - 0.098 12.1 0.0 0.41 10.1 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain KaiC PF06745.8 EFE43789.1 - 0.11 11.5 0.0 0.33 10.0 0.0 1.8 2 0 0 2 2 2 0 KaiC T2SE PF00437.15 EFE43789.1 - 0.14 11.0 0.0 0.26 10.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein FA_hydroxylase PF04116.8 EFE43790.1 - 1.8e-16 60.5 11.8 1.8e-16 60.5 8.2 2.0 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily OmpA_membrane PF01389.12 EFE43790.1 - 0.077 12.5 0.0 0.24 10.9 0.0 1.7 2 0 0 2 2 2 0 OmpA-like transmembrane domain HA2 PF04408.18 EFE43791.1 - 5.6e-18 64.8 0.0 1.6e-17 63.4 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EFE43791.1 - 5.4e-16 58.4 0.0 1.3e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EFE43791.1 - 9.4e-13 47.8 0.0 4.4e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE43791.1 - 0.00013 21.4 0.0 0.00038 20.0 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.1 EFE43791.1 - 0.0027 17.1 0.0 0.0068 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 EFE43791.1 - 0.0083 16.2 0.0 0.023 14.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain KaiC PF06745.8 EFE43791.1 - 0.08 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 KaiC Fungal_trans_2 PF11951.3 EFE43792.1 - 0.016 13.8 0.0 0.035 12.7 0.0 1.5 1 0 0 1 1 1 0 Fungal specific transcription factor domain Ank_2 PF12796.2 EFE43793.1 - 1e-19 70.6 0.0 1.1e-09 38.4 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFE43793.1 - 1.8e-11 43.2 0.0 4.8e-05 22.9 0.0 5.0 5 1 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.1 EFE43793.1 - 6.5e-09 35.7 0.0 0.0038 17.4 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE43793.1 - 2.3e-06 27.9 0.0 0.026 15.0 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE43793.1 - 5.7e-06 26.0 0.0 0.0067 16.5 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat vWA-TerF-like PF10138.4 EFE43793.1 - 0.0021 17.9 0.0 0.0044 16.8 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus SseC PF04888.7 EFE43793.1 - 3.5 6.8 13.7 5.5 6.2 9.5 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Trypsin_2 PF13365.1 EFE43795.1 - 1.6e-05 24.8 0.0 2.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_C4 PF00863.14 EFE43795.1 - 0.13 11.2 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C4 Kelch_6 PF13964.1 EFE43796.1 - 0.0021 18.1 0.0 3.6 7.9 0.0 2.8 3 0 0 3 3 3 2 Kelch motif RTA1 PF04479.8 EFE43797.1 - 8.3e-18 64.6 1.8 1.5e-17 63.8 1.3 1.3 1 1 0 1 1 1 1 RTA1 like protein SNF2_N PF00176.18 EFE43798.1 - 1.3e-63 214.5 0.1 2.1e-63 213.9 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE43798.1 - 5.2e-12 45.4 0.0 1.3e-11 44.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE43798.1 - 1.9e-08 34.3 0.0 5.5e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.20 EFE43798.1 - 2.6e-05 23.7 11.9 2.6e-05 23.7 8.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE43798.1 - 0.00021 21.0 11.5 0.00021 21.0 7.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFE43798.1 - 0.00084 19.3 11.7 0.00084 19.3 8.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) C2 PF00168.25 EFE43799.1 - 1.4e-08 34.4 0.0 2.6e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pex2_Pex12 PF04757.9 EFE43800.1 - 2.6e-42 144.8 4.2 3.2e-42 144.4 2.9 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.1 EFE43800.1 - 2.9e-11 42.9 9.8 4.7e-11 42.3 6.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFE43800.1 - 1.2e-10 40.9 7.6 1.8e-10 40.3 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE43800.1 - 1.9e-10 40.6 9.4 2.9e-10 39.9 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE43800.1 - 1.8e-09 37.1 5.7 2.6e-09 36.6 3.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE43800.1 - 5.2e-08 32.4 6.7 8.1e-08 31.8 4.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EFE43800.1 - 3.4e-06 26.8 9.4 5.8e-06 26.0 6.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFE43800.1 - 4e-06 26.4 2.3 4.5e-06 26.2 0.7 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.2 EFE43800.1 - 3.3e-05 23.9 7.4 7.5e-05 22.7 5.1 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_6 PF14835.1 EFE43800.1 - 0.0012 18.6 3.3 0.0021 17.8 2.3 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 EFE43800.1 - 0.0063 16.3 3.0 0.011 15.5 2.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.3 EFE43800.1 - 0.0092 15.4 4.8 0.017 14.6 3.4 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 EFE43800.1 - 0.12 12.0 8.2 0.22 11.1 5.7 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain IBR PF01485.16 EFE43800.1 - 1.4 8.8 7.3 3.9 7.4 5.0 1.8 1 1 0 1 1 1 0 IBR domain EXS PF03124.9 EFE43801.1 - 1.9e-90 303.3 8.5 2.3e-90 303.1 5.9 1.0 1 0 0 1 1 1 1 EXS family DUF3431 PF11913.3 EFE43802.1 - 1.7e-71 240.2 3.2 3.8e-69 232.5 2.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) NIR_SIR PF01077.17 EFE43803.1 - 7.9e-52 174.7 0.0 1.3e-43 148.1 0.0 2.9 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 EFE43803.1 - 8.1e-29 99.0 0.0 7.2e-14 51.1 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.20 EFE43803.1 - 2e-27 95.9 0.0 3.9e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.14 EFE43803.1 - 2.8e-05 23.7 0.6 8.4e-05 22.1 0.1 1.9 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Flavodoxin_NdrI PF07972.6 EFE43803.1 - 0.081 12.8 0.0 0.28 11.0 0.0 2.0 1 0 0 1 1 1 0 NrdI Flavodoxin like Kei1 PF08552.6 EFE43804.1 - 4.8e-42 143.7 0.0 8.3e-42 142.9 0.0 1.4 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Ras PF00071.17 EFE43805.1 - 1.9e-47 160.6 1.8 4.1e-46 156.3 1.3 2.0 1 1 0 1 1 1 1 Ras family Miro PF08477.8 EFE43805.1 - 1.9e-13 50.9 0.1 1.1e-12 48.5 0.0 2.0 1 1 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE43805.1 - 9.1e-11 41.3 0.6 1.9e-10 40.2 0.4 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFE43805.1 - 1.9e-05 24.1 0.1 4.3e-05 23.0 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CbiA PF01656.18 EFE43805.1 - 0.095 12.0 0.3 0.25 10.7 0.1 1.8 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain CENP-B_dimeris PF09026.5 EFE43806.1 - 0.035 14.3 1.4 0.035 14.3 1.0 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Mak16 PF04874.9 EFE43806.1 - 0.052 13.6 6.9 0.051 13.6 4.8 1.1 1 0 0 1 1 1 0 Mak16 protein C-terminal region BSP_II PF05432.6 EFE43806.1 - 0.093 11.9 9.0 0.09 12.0 6.2 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) E7 PF00527.13 EFE43806.1 - 0.24 11.5 2.7 0.29 11.3 1.9 1.1 1 0 0 1 1 1 0 E7 protein, Early protein Radial_spoke PF04712.7 EFE43806.1 - 3.6 6.2 6.0 3.7 6.1 4.2 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein Myc_N PF01056.13 EFE43806.1 - 3.8 6.5 8.6 4.1 6.4 6.0 1.0 1 0 0 1 1 1 0 Myc amino-terminal region Ribosomal_60s PF00428.14 EFE43806.1 - 6.5 7.2 12.3 6.9 7.1 8.6 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein Nucleoplasmin PF03066.10 EFE43806.1 - 7.6 6.0 9.4 8.5 5.8 6.5 1.1 1 0 0 1 1 1 0 Nucleoplasmin ATP-synt_C PF00137.16 EFE43807.1 - 3.5e-22 78.0 22.1 2.6e-13 49.6 3.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C MoCF_biosynth PF00994.19 EFE43808.1 - 2.2e-11 43.3 0.0 2.6e-11 43.0 0.0 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_N PF03453.12 EFE43809.1 - 3.4e-33 114.2 1.8 5e-33 113.7 1.2 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.19 EFE43809.1 - 3.9e-30 104.1 0.0 1.1e-25 89.7 0.0 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_C PF03454.10 EFE43809.1 - 3.9e-18 65.1 0.1 8.7e-18 64.0 0.1 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) DDHD PF02862.12 EFE43810.1 - 2.2e-44 151.9 0.0 3.5e-42 144.7 0.0 2.5 1 1 0 1 1 1 1 DDHD domain Ribosomal_S9 PF00380.14 EFE43810.1 - 0.018 15.2 0.0 0.35 11.1 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein S9/S16 Abhydrolase_6 PF12697.2 EFE43810.1 - 0.044 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family PT-HINT PF07591.6 EFE43811.1 - 0.15 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Pretoxin HINT domain RAM PF15320.1 EFE43811.1 - 9.7 6.5 13.1 0.39 10.9 3.9 2.4 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein FAD_binding_3 PF01494.14 EFE43812.1 - 2.1e-54 184.9 0.0 4.9e-38 131.0 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Phe_hydrox_dim PF07976.7 EFE43812.1 - 8.1e-37 126.4 0.0 1.4e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.19 EFE43812.1 - 0.00029 19.8 0.0 0.0015 17.4 0.0 1.8 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE43812.1 - 0.019 14.9 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.11 EFE43812.1 - 0.019 14.3 0.0 0.35 10.2 0.0 2.3 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.9 EFE43812.1 - 0.035 13.9 0.0 0.11 12.4 0.0 1.9 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFE43812.1 - 0.055 13.8 0.0 0.22 11.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF4403 PF14356.1 EFE43812.1 - 0.091 11.0 0.0 0.15 10.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4403) Lycopene_cycl PF05834.7 EFE43812.1 - 0.19 10.5 0.0 0.3 9.9 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.9 EFE43812.1 - 0.24 9.8 0.0 0.38 9.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein DUF866 PF05907.8 EFE43813.1 - 5.4e-21 74.7 0.9 7.3e-21 74.3 0.5 1.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) YL1 PF05764.8 EFE43813.1 - 0.016 14.7 4.8 0.02 14.5 3.3 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DUF755 PF05501.6 EFE43813.1 - 0.028 14.4 10.1 0.037 14.0 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Myc_N PF01056.13 EFE43814.1 - 0.16 11.0 4.6 0.19 10.8 3.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region FAM176 PF14851.1 EFE43814.1 - 0.49 10.0 2.3 0.53 9.9 1.6 1.1 1 0 0 1 1 1 0 FAM176 family Nucleoplasmin PF03066.10 EFE43814.1 - 7.6 6.0 6.8 9.7 5.7 4.7 1.1 1 0 0 1 1 1 0 Nucleoplasmin MNE1 PF13762.1 EFE43815.1 - 0.013 15.6 0.9 0.016 15.3 0.6 1.1 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component Ras PF00071.17 EFE43816.1 - 2.7e-47 160.1 0.0 3.4e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE43816.1 - 2.6e-11 44.0 0.0 4e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE43816.1 - 0.00014 21.1 0.0 0.00031 20.0 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFE43816.1 - 0.019 14.1 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit WBP-1 PF11669.3 EFE43817.1 - 0.033 14.2 0.2 0.33 11.0 0.2 2.2 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF4131 PF13567.1 EFE43817.1 - 1.5 8.2 6.8 3.7 6.9 4.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PAP2 PF01569.16 EFE43818.1 - 2.6e-17 62.7 2.7 9.8e-17 60.8 1.9 1.9 1 0 0 1 1 1 1 PAP2 superfamily Peptidase_C48 PF02902.14 EFE43820.1 - 5.8e-27 94.7 0.0 9.1e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Pox_Ag35 PF03286.9 EFE43821.1 - 0.49 9.8 4.2 0.89 9.0 2.9 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MSA_2 PF00985.12 EFE43821.1 - 0.63 10.1 7.2 1.3 9.1 5.0 1.4 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family LPP PF04728.8 EFE43822.1 - 0.00087 19.0 3.1 0.07 12.9 0.2 3.6 1 1 2 3 3 3 1 Lipoprotein leucine-zipper Reo_sigmaC PF04582.7 EFE43822.1 - 0.0046 16.1 4.1 0.019 14.1 2.7 1.8 1 1 0 1 1 1 1 Reovirus sigma C capsid protein ADIP PF11559.3 EFE43822.1 - 0.006 16.4 2.2 0.33 10.8 0.2 2.4 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding DUF1664 PF07889.7 EFE43822.1 - 0.024 14.4 4.4 2.8 7.7 0.8 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) BicD PF09730.4 EFE43822.1 - 0.037 12.3 1.4 0.08 11.2 1.0 1.5 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D Laminin_I PF06008.9 EFE43822.1 - 0.043 13.1 0.3 0.15 11.3 0.0 1.8 1 1 1 2 2 2 0 Laminin Domain I COG5 PF10392.4 EFE43822.1 - 0.055 13.4 1.2 0.33 10.8 0.8 2.3 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Baculo_PEP_C PF04513.7 EFE43822.1 - 0.055 13.2 0.2 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus WEMBL PF05701.6 EFE43822.1 - 0.06 11.8 0.1 0.091 11.2 0.1 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light CENP-F_leu_zip PF10473.4 EFE43822.1 - 0.073 12.9 0.6 0.5 10.2 0.2 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RasGAP_C PF03836.10 EFE43822.1 - 0.14 11.7 0.8 0.28 10.8 0.1 1.8 2 0 0 2 2 2 0 RasGAP C-terminus NPV_P10 PF05531.7 EFE43822.1 - 0.17 12.1 2.1 38 4.6 0.0 3.4 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.6 EFE43822.1 - 0.36 10.6 2.9 0.8 9.4 2.0 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.5 EFE43822.1 - 0.55 10.3 3.8 2 8.5 0.7 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Macoilin PF09726.4 EFE43822.1 - 0.78 7.9 7.0 0.031 12.5 0.5 1.7 2 0 0 2 2 2 0 Transmembrane protein Sulfotransfer_3 PF13469.1 EFE43823.1 - 0.0023 18.8 0.9 0.0059 17.5 0.6 1.6 1 1 0 1 1 1 1 Sulfotransferase family Pepsin-I3 PF06394.8 EFE43823.1 - 0.041 13.5 0.9 0.076 12.6 0.4 1.6 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain Sulfotransfer_3 PF13469.1 EFE43824.1 - 0.0085 17.0 0.2 0.03 15.2 0.1 1.8 1 1 0 1 1 1 1 Sulfotransferase family DUF1542 PF07564.6 EFE43824.1 - 0.026 14.5 0.1 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) adh_short PF00106.20 EFE43825.1 - 4.1e-29 101.6 0.0 5.9e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE43825.1 - 1.9e-24 86.7 0.1 2.3e-24 86.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE43825.1 - 2.9e-12 46.6 0.2 7.2e-12 45.3 0.1 1.6 1 1 0 1 1 1 1 KR domain DENN PF02141.16 EFE43827.1 - 1.1e-37 129.5 0.0 1.9e-37 128.8 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.13 EFE43827.1 - 0.00015 21.6 0.0 0.00044 20.1 0.0 1.9 1 0 0 1 1 1 1 uDENN domain Elongin_A PF06881.6 EFE43827.1 - 0.015 15.6 6.4 0.015 15.6 4.4 2.3 2 1 1 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A TMF_TATA_bd PF12325.3 EFE43827.1 - 2.3 7.9 18.2 0.32 10.7 3.6 2.8 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DivIVA PF05103.8 EFE43827.1 - 2.7 8.0 13.9 0.69 9.9 4.5 2.7 1 1 1 2 2 2 0 DivIVA protein Git3 PF11710.3 EFE43828.1 - 2.3e-23 82.8 18.5 5.6e-23 81.5 12.8 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 EFE43828.1 - 9.7e-10 38.0 0.6 9.7e-10 38.0 0.4 2.2 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.6 EFE43828.1 - 0.25 10.1 18.0 0.028 13.3 9.3 1.6 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor MOR2-PAG1_N PF14222.1 EFE43829.1 - 1.1e-221 737.3 0.0 2e-221 736.4 0.0 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 EFE43829.1 - 1.1e-93 313.8 0.1 2.7e-93 312.5 0.1 1.8 1 0 0 1 1 1 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 EFE43829.1 - 4.6e-40 137.1 12.8 7.8e-17 60.2 0.0 4.0 2 1 1 3 3 3 3 Cell morphogenesis central region FAD_binding_1 PF00667.15 EFE43830.1 - 3.8e-63 212.8 0.0 5.6e-63 212.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 EFE43830.1 - 1e-32 113.1 0.7 2e-32 112.1 0.5 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EFE43830.1 - 2.5e-23 82.7 0.0 2e-22 79.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 EFE43830.1 - 0.013 15.4 0.1 0.27 11.2 0.0 2.4 2 0 0 2 2 2 0 Flavodoxin domain RRM_1 PF00076.17 EFE43831.1 - 5.9e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE43831.1 - 0.016 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF3824 PF12868.2 EFE43832.1 - 0.025 15.5 1.5 0.034 15.0 1.1 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) PAPS_reduct PF01507.14 EFE43833.1 - 4e-29 101.6 0.0 2.9e-27 95.5 0.0 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family RPA_C PF08784.6 EFE43834.1 - 2e-13 50.6 0.0 4.6e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 EFE43834.1 - 0.00019 21.2 0.0 0.0013 18.4 0.0 2.1 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain DEAD PF00270.24 EFE43835.1 - 2.6e-43 147.4 0.0 5.4e-43 146.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE43835.1 - 1.6e-21 75.9 0.2 6.8e-21 73.9 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.7 EFE43835.1 - 6.4e-20 70.7 3.0 2.3e-19 68.9 2.1 2.1 1 0 0 1 1 1 1 DBP10CT (NUC160) domain AA_permease PF00324.16 EFE43837.1 - 4.4e-116 388.0 41.3 9e-74 248.5 9.0 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.1 EFE43837.1 - 2.7e-32 111.8 44.6 1e-31 109.9 30.9 1.7 1 1 0 1 1 1 1 Amino acid permease PrgI PF12666.2 EFE43837.1 - 4.8 7.3 14.0 0.051 13.7 1.2 3.7 4 1 1 5 5 5 0 PrgI family protein DEAD PF00270.24 EFE43838.1 - 1.5e-45 154.6 0.1 2.9e-45 153.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EFE43838.1 - 1.7e-25 88.2 0.1 4.2e-25 87.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EFE43838.1 - 3e-22 78.2 0.0 9.6e-22 76.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 EFE43838.1 - 0.001 19.0 0.0 0.0032 17.4 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain SNF2_N PF00176.18 EFE43838.1 - 0.0012 17.7 0.0 0.0024 16.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DnaJ PF00226.26 EFE43839.1 - 1.1e-14 53.8 2.9 1.8e-14 53.2 0.6 2.3 2 0 0 2 2 2 1 DnaJ domain CT47 PF15623.1 EFE43839.1 - 0.71 9.5 8.7 1.1 8.9 6.0 1.2 1 0 0 1 1 1 0 Cancer/testis gene family 47 MatE PF01554.13 EFE43840.1 - 3.4e-54 182.8 31.7 9.3e-30 103.3 8.0 2.3 2 0 0 2 2 2 2 MatE DUF202 PF02656.10 EFE43841.1 - 3.4e-19 68.8 1.3 3.4e-19 68.8 0.9 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF202) COX4_pro_2 PF07835.7 EFE43841.1 - 0.25 11.3 1.2 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV NUDIX PF00293.23 EFE43842.1 - 6.4e-29 100.3 0.0 8.9e-29 99.8 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain zf-C2H2_4 PF13894.1 EFE43844.1 - 9.4e-08 31.8 6.3 0.002 18.3 1.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE43844.1 - 1.6e-06 28.1 13.1 0.00066 19.8 2.6 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFE43844.1 - 0.0048 17.1 9.0 0.86 10.0 2.6 2.6 2 0 0 2 2 2 2 Zinc-finger double domain zinc-ribbons_6 PF07191.7 EFE43844.1 - 0.049 13.4 0.4 0.14 11.9 0.3 1.7 1 0 0 1 1 1 0 zinc-ribbons zf-C2H2_jaz PF12171.3 EFE43844.1 - 0.2 11.8 2.2 0.48 10.6 1.5 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Pkinase PF00069.20 EFE43845.1 - 8.4e-19 67.7 0.0 1.4e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.27 EFE43845.1 - 1.7e-16 59.3 2.9 8.5e-09 34.9 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat HEAT PF02985.17 EFE43845.1 - 3.4e-11 42.2 6.6 0.04 13.9 0.1 6.7 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.1 EFE43845.1 - 4.6e-06 26.8 0.3 0.96 9.7 0.0 3.9 1 1 3 4 4 4 4 HEAT repeats Pkinase_Tyr PF07714.12 EFE43845.1 - 4.8e-05 22.5 0.0 7.7e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2454 PF10521.4 EFE43845.1 - 0.0058 15.6 0.6 0.016 14.2 0.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2454) HEAT_EZ PF13513.1 EFE43845.1 - 0.47 11.0 4.0 0.77 10.3 0.2 3.3 4 0 0 4 4 4 0 HEAT-like repeat RabGAP-TBC PF00566.13 EFE43846.1 - 1e-41 142.8 0.0 2.4e-40 138.3 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Peptidase_M6 PF05547.6 EFE43847.1 - 3.7e-06 25.2 0.5 0.00068 17.8 0.4 2.2 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 Abhydrolase_4 PF08386.5 EFE43848.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 TAP-like protein THF_DHG_CYH PF00763.18 EFE43848.1 - 0.087 12.8 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain COesterase PF00135.23 EFE43849.1 - 2.8e-105 353.0 0.0 3.4e-105 352.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE43849.1 - 7.3e-07 28.9 0.0 2.3e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFE43849.1 - 0.00019 20.6 0.0 0.00043 19.5 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFE43849.1 - 0.00051 19.9 0.0 0.00078 19.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE43849.1 - 0.0021 17.8 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 EFE43849.1 - 0.038 12.8 0.0 0.059 12.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme SmpA_OmlA PF04355.8 EFE43849.1 - 0.046 13.3 0.5 4.6 6.9 0.0 2.6 2 0 0 2 2 2 0 SmpA / OmlA family DUF1749 PF08538.5 EFE43849.1 - 0.064 12.1 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Nop14 PF04147.7 EFE43850.1 - 4.8e-267 888.2 22.6 6.9e-267 887.7 15.7 1.2 1 0 0 1 1 1 1 Nop14-like family PPR_3 PF13812.1 EFE43852.1 - 5.1e-09 35.7 0.1 0.18 12.2 0.0 7.2 8 0 0 8 8 8 2 Pentatricopeptide repeat domain PPR_2 PF13041.1 EFE43852.1 - 5.2e-07 29.5 0.0 0.18 11.8 0.0 5.3 6 0 0 6 6 6 2 PPR repeat family DUF1315 PF07023.7 EFE43852.1 - 0.041 13.7 0.4 0.095 12.5 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1315) PPR PF01535.15 EFE43852.1 - 0.11 12.4 1.4 4.7 7.4 0.0 4.3 5 0 0 5 5 5 0 PPR repeat ORC3_N PF07034.6 EFE43853.1 - 2.9e-18 65.9 0.1 4.6e-17 62.0 0.0 2.1 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus FliG_C PF01706.11 EFE43853.1 - 0.092 12.7 0.1 0.22 11.5 0.1 1.8 1 1 0 1 1 1 0 FliG C-terminal domain Reo_sigmaC PF04582.7 EFE43854.1 - 0.024 13.8 0.5 0.034 13.3 0.3 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Sec66 PF09802.4 EFE43855.1 - 8e-74 247.1 0.3 9.6e-74 246.8 0.2 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF1539 PF07560.6 EFE43855.1 - 0.055 13.3 0.0 0.099 12.5 0.0 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) DUF2819 PF10995.3 EFE43855.1 - 0.078 11.7 0.2 0.11 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2819) Duffy_binding PF05424.6 EFE43855.1 - 0.12 12.2 2.4 0.26 11.1 1.7 1.7 1 1 0 1 1 1 0 Duffy binding domain AAA PF00004.24 EFE43856.1 - 1.7e-46 157.6 0.0 5.8e-42 143.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 EFE43856.1 - 4e-06 26.3 0.0 9.9e-06 25.0 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 EFE43856.1 - 6.7e-06 26.2 0.0 5.4e-05 23.2 0.0 2.6 2 0 0 2 2 1 1 AAA ATPase domain AAA_2 PF07724.9 EFE43856.1 - 1.2e-05 25.3 0.0 2.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Bromodomain PF00439.20 EFE43856.1 - 6.5e-05 22.7 0.0 0.00021 21.1 0.0 1.8 1 0 0 1 1 1 1 Bromodomain AAA_22 PF13401.1 EFE43856.1 - 9.4e-05 22.5 0.1 0.0024 18.0 0.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFE43856.1 - 0.00021 21.0 0.0 0.00059 19.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 EFE43856.1 - 0.00098 18.5 0.0 0.003 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE43856.1 - 0.001 18.7 0.0 0.026 14.2 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 EFE43856.1 - 0.0034 17.2 0.0 0.011 15.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.17 EFE43856.1 - 0.0042 17.2 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.8 EFE43856.1 - 0.0043 15.8 0.0 0.0069 15.1 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 EFE43856.1 - 0.0051 16.6 0.0 0.019 14.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE43856.1 - 0.0083 16.9 0.0 0.0083 16.9 0.0 3.4 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.22 EFE43856.1 - 0.023 15.0 0.0 0.077 13.2 0.0 1.9 1 0 0 1 1 1 0 ABC transporter Sigma54_activ_2 PF14532.1 EFE43856.1 - 0.028 14.4 0.0 0.34 10.9 0.0 2.5 3 0 0 3 3 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 EFE43856.1 - 0.035 13.2 0.0 0.08 12.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EFE43856.1 - 0.06 12.8 0.0 3 7.2 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain PhoH PF02562.11 EFE43856.1 - 0.062 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein RuvB_N PF05496.7 EFE43856.1 - 0.062 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_30 PF13604.1 EFE43856.1 - 0.062 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EFE43856.1 - 0.075 12.6 0.1 0.28 10.8 0.0 2.1 1 1 0 1 1 1 0 NACHT domain AAA_3 PF07726.6 EFE43856.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.12 EFE43856.1 - 0.16 10.7 0.0 0.29 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Torsin PF06309.6 EFE43856.1 - 0.32 10.9 0.0 0.96 9.3 0.0 1.7 2 0 0 2 2 1 0 Torsin PIF1 PF05970.9 EFE43857.1 - 3.9e-99 332.0 0.0 6.1e-99 331.3 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.1 EFE43857.1 - 2e-64 216.7 1.1 5.9e-64 215.1 0.8 1.8 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.1 EFE43857.1 - 5.3e-05 22.8 0.0 0.0001 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE43857.1 - 0.00029 20.5 0.1 0.0014 18.3 0.1 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_5 PF07728.9 EFE43857.1 - 0.011 15.4 0.2 0.069 12.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PhoH PF02562.11 EFE43857.1 - 0.031 13.4 0.0 0.06 12.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.10 EFE43857.1 - 0.033 14.0 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_25 PF13481.1 EFE43857.1 - 0.076 12.4 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFE43857.1 - 0.11 12.3 0.0 0.75 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 EFE43857.1 - 0.34 9.7 0.0 0.64 8.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Dimer_Tnp_hAT PF05699.9 EFE43858.1 - 1.3e-13 50.3 0.0 3.2e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 EFE43858.1 - 0.012 15.5 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) BTV_NS2 PF04514.7 EFE43859.1 - 1 8.1 24.4 1.3 7.8 16.9 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Hid1 PF12722.2 EFE43859.1 - 1.4 6.4 25.6 1.5 6.4 17.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PPP4R2 PF09184.6 EFE43859.1 - 4.5 6.7 34.8 6.1 6.2 24.1 1.3 1 0 0 1 1 1 0 PPP4R2 Ycf1 PF05758.7 EFE43859.1 - 5.8 4.5 17.7 6.7 4.2 12.3 1.3 1 0 0 1 1 1 0 Ycf1 DUF1308 PF07000.6 EFE43860.1 - 1.8e-77 260.4 0.0 8.3e-77 258.2 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1308) WD40 PF00400.27 EFE43861.1 - 2.5e-10 39.7 5.8 2.4e-06 27.1 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat MRG PF05712.8 EFE43861.1 - 0.035 13.0 0.0 0.045 12.6 0.0 1.2 1 0 0 1 1 1 0 MRG Mito_carr PF00153.22 EFE43862.1 - 7.3e-38 128.1 2.9 1.6e-18 66.1 0.2 2.5 3 0 0 3 3 3 2 Mitochondrial carrier protein Ribonuc_red_sm PF00268.16 EFE43863.1 - 6.4e-120 399.3 1.5 8.1e-120 399.0 1.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF1434 PF07254.7 EFE43863.1 - 0.033 14.0 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1434) G6PD_C PF02781.11 EFE43865.1 - 5.5e-135 448.8 0.0 7.5e-135 448.4 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 EFE43865.1 - 9.3e-56 188.9 0.0 1.8e-55 188.0 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Abhydrolase_3 PF07859.8 EFE43866.1 - 2.5e-32 112.1 0.0 3.8e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE43866.1 - 0.00067 19.4 0.0 0.00091 19.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EFE43866.1 - 0.00096 19.4 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain AKNA PF12443.3 EFE43866.1 - 0.08 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 AT-hook-containing transcription factor Chlorophyllase2 PF12740.2 EFE43866.1 - 0.15 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Nol1_Nop2_Fmu PF01189.12 EFE43867.1 - 1.3e-37 129.6 0.0 2.7e-16 59.7 0.0 4.0 2 1 2 4 4 4 4 NOL1/NOP2/sun family Ubie_methyltran PF01209.13 EFE43867.1 - 0.18 10.9 0.0 0.71 8.9 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family DUF3816 PF12822.2 EFE43868.1 - 0.0099 15.7 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3816) CYSTM PF12734.2 EFE43869.1 - 3e-10 40.0 15.9 3e-10 40.0 11.0 4.1 1 1 1 2 2 2 1 Cysteine-rich TM module stress tolerance DUF2968 PF11180.3 EFE43870.1 - 0.0017 17.7 9.5 0.0017 17.7 6.6 4.2 3 1 1 4 4 4 1 Protein of unknown function (DUF2968) Spectrin PF00435.16 EFE43870.1 - 0.015 15.5 9.2 0.015 15.5 6.4 3.7 3 1 0 3 3 3 0 Spectrin repeat APG6 PF04111.7 EFE43870.1 - 0.055 12.5 47.6 0.011 14.8 13.0 3.2 2 1 1 3 3 3 0 Autophagy protein Apg6 MscS_porin PF12795.2 EFE43870.1 - 0.17 11.2 44.6 0.039 13.2 6.7 3.5 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain KxDL PF10241.4 EFE43870.1 - 0.26 11.2 0.1 0.26 11.2 0.1 4.1 3 1 1 4 4 4 0 Uncharacterized conserved protein Occludin_ELL PF07303.8 EFE43870.1 - 2.4 8.9 33.8 0.24 12.1 6.5 4.4 2 1 2 4 4 4 0 Occludin homology domain DUF1664 PF07889.7 EFE43870.1 - 3.8 7.3 19.6 1.9 8.2 2.3 3.7 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 EFE43870.1 - 6 6.7 41.6 2.2 8.1 13.1 3.9 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 EFE43870.1 - 6 6.4 44.8 4.4 6.8 10.4 4.1 2 1 1 3 3 3 0 IncA protein Baculo_PEP_C PF04513.7 EFE43870.1 - 7.4 6.3 17.0 1.4 8.7 2.4 3.5 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RNA_pol_Rpb5_C PF01191.14 EFE43871.1 - 5.1e-35 118.9 0.2 8.8e-35 118.1 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 EFE43871.1 - 1.4e-30 105.5 0.0 2.1e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.7 EFE43871.1 - 0.00082 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Restriction endonuclease DLH PF01738.13 EFE43872.1 - 3.1e-10 39.7 0.0 3.9e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EFE43872.1 - 0.00023 20.9 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF21 PF01595.15 EFE43874.1 - 0.0075 15.5 0.3 0.0092 15.2 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF21 DUF4199 PF13858.1 EFE43874.1 - 0.06 13.2 0.0 0.077 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) ATP-synt_8 PF00895.15 EFE43874.1 - 0.2 11.8 1.8 0.43 10.8 1.3 1.5 1 0 0 1 1 1 0 ATP synthase protein 8 DUF1754 PF08555.5 EFE43875.1 - 1.1e-14 54.7 19.2 2e-14 53.9 13.3 1.4 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) NDUF_B4 PF07225.7 EFE43875.1 - 0.43 10.3 5.9 0.13 12.1 1.4 1.9 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) MRP-S26 PF14943.1 EFE43875.1 - 1.1 8.7 17.2 1.7 8.1 12.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 MFMR PF07777.6 EFE43875.1 - 3.8 7.3 9.8 1.3 8.9 4.5 1.7 1 1 1 2 2 2 0 G-box binding protein MFMR PTPA PF03095.10 EFE43876.1 - 8.1e-109 363.4 0.0 9.5e-109 363.1 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF202 PF02656.10 EFE43877.1 - 1.3e-24 86.2 0.4 1.3e-24 86.2 0.3 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF202) MIP-T3 PF10243.4 EFE43878.1 - 5.8e-06 25.0 24.3 7.6e-06 24.6 16.8 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Pollen_allerg_2 PF01620.11 EFE43878.1 - 0.37 11.0 1.8 0.66 10.2 1.2 1.3 1 0 0 1 1 1 0 Ribonuclease (pollen allergen) SPX PF03105.14 EFE43878.1 - 1.5 8.5 20.0 2 8.0 13.9 1.2 1 0 0 1 1 1 0 SPX domain SOBP PF15279.1 EFE43878.1 - 3.9 7.7 6.8 7.6 6.8 4.8 1.4 1 1 0 1 1 1 0 Sine oculis-binding protein RNA_polI_A34 PF08208.6 EFE43879.1 - 0.0013 18.4 7.9 0.0013 18.4 5.4 3.1 3 0 0 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 PAF-AH_p_II PF03403.8 EFE43880.1 - 4.5e-15 54.8 0.0 1.2e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 EFE43880.1 - 2.3e-09 37.1 0.1 3.9e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE43880.1 - 8.4e-05 22.5 0.1 0.00014 21.8 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 EFE43880.1 - 0.0032 16.3 0.1 0.011 14.6 0.0 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.3 EFE43880.1 - 0.095 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase DUF3115 PF11312.3 EFE43881.1 - 1.1e-90 303.6 0.0 2.5e-90 302.5 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3115) Band_7 PF01145.20 EFE43883.1 - 9.5e-25 87.5 7.4 1.4e-24 86.9 4.8 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family GatB_Yqey PF02637.13 EFE43883.1 - 0.023 14.4 0.6 0.041 13.5 0.4 1.5 1 0 0 1 1 1 0 GatB domain DUF2884 PF11101.3 EFE43883.1 - 0.028 13.7 0.7 0.05 12.9 0.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) UcrQ PF02939.11 EFE43884.1 - 3.1e-21 74.9 1.4 1.4e-20 72.9 0.9 1.8 1 1 1 2 2 2 1 UcrQ family F-box-like_2 PF13013.1 EFE43884.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 F-box-like domain Ribosomal_L7Ae PF01248.21 EFE43885.1 - 3.4e-18 64.9 1.5 3.4e-18 64.9 1.0 2.5 2 1 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Avirulence PF03377.8 EFE43885.1 - 0.07 11.8 0.0 0.093 11.4 0.0 1.1 1 0 0 1 1 1 0 Xanthomonas avirulence protein, Avr/PthA FSIP1 PF15554.1 EFE43887.1 - 0.07 11.9 0.1 0.09 11.5 0.0 1.1 1 0 0 1 1 1 0 FSIP1 family SET PF00856.23 EFE43888.1 - 0.0045 17.3 0.0 0.0091 16.3 0.0 1.5 1 0 0 1 1 1 1 SET domain Fungal_trans PF04082.13 EFE43889.1 - 1.4e-29 102.7 0.7 2.6e-29 101.8 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE43889.1 - 1.1e-09 37.9 11.7 1.8e-09 37.3 8.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.4 EFE43889.1 - 4.2 5.5 6.3 9.5 4.3 0.0 2.1 2 0 0 2 2 2 0 Transmembrane protein Transketolase_N PF00456.16 EFE43890.1 - 4.8e-142 472.6 0.0 8.9e-142 471.7 0.0 1.5 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 EFE43890.1 - 1.1e-45 155.3 0.0 1.7e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EFE43890.1 - 6.9e-14 51.8 0.0 1.5e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 EFE43890.1 - 1.7e-06 27.1 0.0 0.00043 19.2 0.0 2.2 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase Mur_ligase_C PF02875.16 EFE43890.1 - 0.054 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain E1_dh PF00676.15 EFE43890.1 - 0.15 10.7 0.1 0.25 10.0 0.1 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component Spermine_synth PF01564.12 EFE43891.1 - 1.5e-05 24.1 0.0 1.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Spermine_synth PF01564.12 EFE43892.1 - 5e-80 267.9 0.0 6.1e-80 267.6 0.0 1.0 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 EFE43892.1 - 0.00039 20.9 0.0 0.00062 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE43892.1 - 0.00075 19.1 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE43892.1 - 0.0013 19.1 0.3 0.0081 16.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.11 EFE43892.1 - 0.0019 17.2 0.0 0.0027 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF43 Methyltransf_25 PF13649.1 EFE43892.1 - 0.008 16.5 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFE43892.1 - 0.013 14.8 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_30 PF05430.6 EFE43892.1 - 0.015 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_23 PF13489.1 EFE43892.1 - 0.056 13.1 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.13 EFE43892.1 - 0.14 11.3 0.6 1.4 8.0 0.2 2.2 1 1 1 2 2 2 0 O-methyltransferase bZIP_1 PF00170.16 EFE43893.1 - 1.8e-08 34.2 9.7 3e-08 33.5 6.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor TMF_TATA_bd PF12325.3 EFE43893.1 - 0.00013 21.7 2.2 0.0002 21.0 1.5 1.2 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.10 EFE43893.1 - 0.0012 18.6 7.5 0.0012 18.6 5.2 2.1 1 1 1 2 2 2 1 Basic region leucine zipper ASD2 PF08687.6 EFE43893.1 - 0.0036 16.6 0.5 0.0044 16.3 0.4 1.1 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 bZIP_Maf PF03131.12 EFE43893.1 - 0.0088 16.3 10.7 0.0088 16.3 7.4 1.4 1 1 0 1 1 1 1 bZIP Maf transcription factor Macoilin PF09726.4 EFE43893.1 - 0.0091 14.3 2.7 0.011 14.0 1.9 1.1 1 0 0 1 1 1 1 Transmembrane protein CENP-F_leu_zip PF10473.4 EFE43893.1 - 0.012 15.5 3.3 0.017 15.0 2.3 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CcmH PF03918.9 EFE43893.1 - 0.024 13.6 0.7 0.044 12.7 0.5 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein TMF_DNA_bd PF12329.3 EFE43893.1 - 0.031 14.0 3.5 0.048 13.4 2.5 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF948 PF06103.6 EFE43893.1 - 0.031 14.1 0.4 0.047 13.5 0.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF2400 PF09674.5 EFE43893.1 - 0.097 12.3 0.5 0.13 11.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) DUF2419 PF10343.4 EFE43893.1 - 0.098 11.9 0.3 0.12 11.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2419) DUF4254 PF14063.1 EFE43893.1 - 0.24 10.9 2.6 0.4 10.2 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4254) IncA PF04156.9 EFE43893.1 - 0.25 10.9 4.6 0.34 10.4 3.2 1.1 1 0 0 1 1 1 0 IncA protein EAP30 PF04157.11 EFE43893.1 - 0.31 10.1 5.7 0.42 9.7 4.0 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family Tup_N PF08581.5 EFE43893.1 - 0.32 11.2 4.1 0.35 11.0 1.3 1.9 1 1 1 2 2 2 0 Tup N-terminal EMP24_GP25L PF01105.19 EFE43893.1 - 0.43 10.2 2.3 0.6 9.7 1.6 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Allexi_40kDa PF05549.6 EFE43893.1 - 7.3 5.7 7.9 1.6 7.9 2.8 1.7 1 1 1 2 2 2 0 Allexivirus 40kDa protein PcfJ PF14284.1 EFE43894.1 - 0.065 12.7 1.2 0.065 12.7 0.8 1.0 1 0 0 1 1 1 0 PcfJ-like protein Wound_ind PF08186.6 EFE43894.1 - 1.2 9.1 4.9 3 7.8 3.4 1.6 1 1 0 1 1 1 0 Wound-inducible basic protein family Plasmodium_Vir PF05795.6 EFE43895.1 - 0.043 13.0 0.4 0.058 12.5 0.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CDC45 PF02724.9 EFE43895.1 - 0.14 10.1 0.7 0.14 10.1 0.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DDRGK PF09756.4 EFE43895.1 - 0.28 10.5 13.1 0.39 10.0 9.1 1.1 1 0 0 1 1 1 0 DDRGK domain Ribosomal_60s PF00428.14 EFE43896.1 - 0.78 10.1 5.4 1.1 9.7 3.7 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein G-alpha PF00503.15 EFE43897.1 - 4.8e-107 358.0 0.1 6e-107 357.7 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EFE43897.1 - 1.6e-13 50.2 1.3 5.2e-09 35.5 0.0 2.6 3 0 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFE43897.1 - 2.1e-06 27.0 0.1 0.003 16.7 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Miro PF08477.8 EFE43897.1 - 0.0027 18.1 0.0 0.33 11.4 0.0 2.8 2 1 0 2 2 2 1 Miro-like protein AAA_29 PF13555.1 EFE43897.1 - 0.039 13.4 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 EFE43897.1 - 0.059 13.3 0.0 9 6.2 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFE43897.1 - 0.081 12.3 0.0 4.3 6.7 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF1713 PF08213.6 EFE43899.1 - 2.9e-12 45.9 20.7 5.7e-12 45.0 14.3 1.5 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) ATP-synt_C PF00137.16 EFE43900.1 - 1.1e-16 60.4 16.2 7.6e-14 51.3 6.7 2.1 2 0 0 2 2 2 2 ATP synthase subunit C p450 PF00067.17 EFE43902.1 - 7e-53 179.7 0.0 1.5e-51 175.3 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 CFEM PF05730.6 EFE43904.1 - 1.1e-05 25.1 5.9 2.3e-05 24.0 4.1 1.5 1 0 0 1 1 1 1 CFEM domain EphA2_TM PF14575.1 EFE43904.1 - 0.15 12.4 0.0 0.45 10.9 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain GSHPx PF00255.14 EFE43905.1 - 4.5e-39 132.1 0.0 6.1e-39 131.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 EFE43905.1 - 0.02 14.5 0.0 0.055 13.1 0.0 1.8 1 1 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.5 EFE43905.1 - 0.027 14.0 0.2 0.11 11.9 0.2 2.0 1 1 0 1 1 1 0 Redoxin Ral PF11058.3 EFE43905.1 - 0.091 12.1 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 Antirestriction protein Ral SCO1-SenC PF02630.9 EFE43905.1 - 0.12 11.9 0.0 0.53 9.8 0.0 1.9 2 0 0 2 2 2 0 SCO1/SenC RR_TM4-6 PF06459.7 EFE43906.1 - 0.44 10.3 3.1 0.46 10.3 2.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ORC6 PF05460.8 EFE43906.1 - 0.82 8.7 6.4 1 8.4 4.5 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Hydrolase_6 PF13344.1 EFE43907.1 - 2e-23 82.1 0.0 4.4e-23 81.0 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFE43907.1 - 1.6e-10 40.5 0.0 1.1e-09 37.8 0.0 2.5 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase PF00702.21 EFE43907.1 - 0.038 14.4 0.0 0.64 10.3 0.0 2.4 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFE43907.1 - 0.11 12.7 0.0 13 5.9 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF676 PF05057.9 EFE43908.1 - 2.8e-27 95.4 0.0 4.2e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 EFE43908.1 - 0.011 15.3 0.1 0.027 14.0 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) RNase_T PF00929.19 EFE43909.1 - 2.2e-08 34.5 0.0 6.8e-08 32.9 0.0 1.8 1 1 0 1 1 1 1 Exonuclease BTK PF00779.14 EFE43909.1 - 0.075 12.6 0.6 0.15 11.6 0.4 1.5 1 0 0 1 1 1 0 BTK motif Ribosomal_L22e PF01776.12 EFE43910.1 - 5.9e-49 164.7 0.7 7.6e-49 164.3 0.5 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family Translin PF01997.11 EFE43911.1 - 1.1e-38 132.8 0.0 1.3e-38 132.6 0.0 1.0 1 0 0 1 1 1 1 Translin family GMP_synt_C PF00958.17 EFE43911.1 - 0.044 13.4 0.0 0.056 13.1 0.0 1.4 1 1 0 1 1 1 0 GMP synthase C terminal domain Pcc1 PF09341.5 EFE43913.1 - 8.2e-23 80.2 2.2 2.5e-22 78.6 1.5 1.7 1 1 0 1 1 1 1 Transcription factor Pcc1 DSPn PF14671.1 EFE43914.1 - 5.4e-40 136.6 0.0 5.4e-37 126.9 0.0 3.1 3 0 0 3 3 3 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 EFE43914.1 - 9.1e-16 57.6 0.0 2.6e-15 56.1 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFE43914.1 - 2.1e-05 23.9 0.0 3.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase YonK PF09642.5 EFE43914.1 - 0.15 11.7 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 YonK protein DUF4296 PF14129.1 EFE43915.1 - 0.046 13.8 0.0 0.1 12.7 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4296) Pyridoxal_deC PF00282.14 EFE43916.1 - 4e-55 186.7 0.0 6e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DUF917 PF06032.7 EFE43916.1 - 5.2e-42 143.6 0.0 7.8e-42 143.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 EFE43917.1 - 1.4e-54 185.1 6.5 4.4e-53 180.2 1.7 2.8 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EFE43917.1 - 1.2e-27 96.5 7.2 1.3e-26 93.2 0.2 2.8 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region DUF917 PF06032.7 EFE43917.1 - 3.3e-10 39.0 0.0 9.9e-10 37.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF917) MutL PF13941.1 EFE43917.1 - 7.1e-06 24.6 1.8 0.0054 15.1 0.2 2.3 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.15 EFE43917.1 - 0.0042 16.4 1.8 0.24 10.6 0.1 3.0 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family StbA PF06406.6 EFE43917.1 - 0.089 11.7 0.7 3.9 6.3 0.3 2.4 2 0 0 2 2 2 0 StbA protein FtsA PF14450.1 EFE43917.1 - 7.2 6.4 8.2 21 4.9 0.0 3.3 3 2 0 3 3 3 0 Cell division protein FtsA Homeobox PF00046.24 EFE43918.1 - 2e-12 46.4 0.0 5.4e-12 45.1 0.0 1.7 1 0 0 1 1 1 1 Homeobox domain MFS_1 PF07690.11 EFE43919.1 - 7.5e-16 57.7 8.8 8.8e-16 57.5 6.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MscS_TM PF12794.2 EFE43919.1 - 0.00098 17.8 0.3 0.0016 17.1 0.0 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel inner membrane domain 1 OATP PF03137.15 EFE43919.1 - 0.0088 14.1 0.9 0.011 13.8 0.2 1.7 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Fungal_trans_2 PF11951.3 EFE43920.1 - 5.6e-50 170.0 0.1 7.4e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE43920.1 - 9.7e-08 31.7 9.8 9.7e-08 31.7 6.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFE43921.1 - 2.3e-31 108.6 0.1 4.5e-31 107.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE43921.1 - 1.5e-07 31.1 8.0 1.5e-07 31.1 5.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.8 EFE43921.1 - 0.17 11.8 0.3 0.45 10.4 0.2 1.6 1 0 0 1 1 1 0 Gal4-like dimerisation domain Pkinase PF00069.20 EFE43922.1 - 2.3e-18 66.3 0.0 4.8e-10 39.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43922.1 - 0.0066 15.5 0.0 3.6 6.5 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase Atrophin-1 PF03154.10 EFE43924.1 - 0.011 13.9 6.0 0.012 13.8 4.2 1.2 1 0 0 1 1 1 0 Atrophin-1 family Creatininase PF02633.9 EFE43924.1 - 0.2 10.7 1.2 0.24 10.4 0.8 1.1 1 0 0 1 1 1 0 Creatinine amidohydrolase CDC45 PF02724.9 EFE43924.1 - 0.51 8.3 7.0 0.65 7.9 4.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Ycf1 PF05758.7 EFE43924.1 - 0.55 7.8 3.1 0.67 7.5 2.1 1.0 1 0 0 1 1 1 0 Ycf1 RR_TM4-6 PF06459.7 EFE43924.1 - 0.61 9.9 4.6 0.67 9.7 3.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AF-4 PF05110.8 EFE43924.1 - 0.75 7.5 12.2 0.82 7.4 8.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MDFI PF15316.1 EFE43924.1 - 0.8 9.6 4.4 1.1 9.2 3.0 1.1 1 0 0 1 1 1 0 MyoD family inhibitor DUF4551 PF15087.1 EFE43924.1 - 0.86 7.8 3.4 0.98 7.7 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MIP-T3 PF10243.4 EFE43924.1 - 1 7.7 17.0 1.2 7.5 11.8 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Spore_coat_CotO PF14153.1 EFE43924.1 - 2.7 7.3 9.2 3.5 7.0 6.4 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF4544 PF15077.1 EFE43924.1 - 2.7 7.4 8.2 3.5 7.0 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4544) NPR3 PF03666.8 EFE43924.1 - 3.4 6.1 10.7 4.3 5.7 7.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 U79_P34 PF03064.11 EFE43924.1 - 3.5 7.0 11.4 4.4 6.7 7.9 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Rtf2 PF04641.7 EFE43924.1 - 4.6 6.3 13.8 6 5.9 9.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger YqfQ PF14181.1 EFE43924.1 - 5 7.1 8.9 8.4 6.4 6.2 1.3 1 0 0 1 1 1 0 YqfQ-like protein DDHD PF02862.12 EFE43924.1 - 6.7 6.4 7.0 7.9 6.2 4.9 1.1 1 0 0 1 1 1 0 DDHD domain RIC3 PF15361.1 EFE43924.1 - 7.1 6.8 7.4 10 6.3 5.1 1.1 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF1510 PF07423.6 EFE43924.1 - 8.3 5.7 11.3 11 5.2 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF1168 PF06658.7 EFE43928.1 - 9.4 5.7 15.8 10 5.6 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Ank_2 PF12796.2 EFE43929.1 - 9.8e-13 48.2 0.1 3.2e-09 37.0 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFE43929.1 - 1.9e-12 46.3 0.3 4.4e-10 38.8 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 EFE43929.1 - 2.9e-09 36.2 0.1 1.6e-06 27.7 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.1 EFE43929.1 - 6.1e-09 36.1 0.1 2.9e-06 27.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE43929.1 - 7.1e-09 35.6 0.5 1e-05 25.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) KilA-N PF04383.8 EFE43929.1 - 9.7e-05 21.9 0.1 0.001 18.6 0.0 2.3 1 1 0 1 1 1 1 KilA-N domain DUF4391 PF14335.1 EFE43929.1 - 0.15 11.4 2.3 0.26 10.6 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) GCS PF03074.11 EFE43930.1 - 1.1e-153 511.6 0.0 1.8e-152 507.7 0.0 2.0 1 1 0 1 1 1 1 Glutamate-cysteine ligase DUF1560 PF07597.6 EFE43930.1 - 0.012 15.5 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1560) UPF0278 PF08745.6 EFE43930.1 - 0.059 12.6 0.1 0.16 11.1 0.0 1.7 2 0 0 2 2 2 0 UPF0278 family DUF2811 PF10929.3 EFE43930.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) CBS PF00571.23 EFE43931.1 - 3.8e-22 77.8 0.3 0.00017 21.2 0.0 5.4 5 0 0 5 5 5 5 CBS domain S10_plectin PF03501.10 EFE43933.1 - 0.057 13.2 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 Plectin/S10 domain DUF2183 PF09949.4 EFE43935.1 - 6e-30 103.1 0.0 1.8e-29 101.5 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) ADH_zinc_N_2 PF13602.1 EFE43936.1 - 2.7e-21 76.7 0.0 6e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE43936.1 - 0.0015 18.2 0.0 0.003 17.3 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFE43936.1 - 0.0027 17.2 0.0 0.0046 16.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase GPP34 PF05719.6 EFE43937.1 - 1.4e-64 217.9 0.3 1.8e-64 217.5 0.2 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) PP-binding PF00550.20 EFE43938.1 - 9.5e-10 38.5 0.3 1.4e-09 38.0 0.2 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 EFE43938.1 - 0.07 13.1 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Acyl-carrier Fer4 PF00037.22 EFE43939.1 - 1.3e-13 49.8 16.5 5e-08 32.2 2.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 EFE43939.1 - 1.1e-11 44.9 10.4 1.7e-11 44.2 7.2 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.1 EFE43939.1 - 4.6e-10 40.1 7.2 0.0002 22.0 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.1 EFE43939.1 - 2.4e-09 36.8 22.1 8.4e-08 31.8 8.4 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 EFE43939.1 - 2.6e-09 37.2 10.8 4.4e-09 36.4 7.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 EFE43939.1 - 2e-08 33.9 21.9 6.1e-06 26.0 8.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 EFE43939.1 - 1.2e-07 31.2 14.7 0.00041 20.0 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 EFE43939.1 - 1.2e-07 31.6 20.3 2.9e-05 24.0 7.9 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.2 EFE43939.1 - 2.3e-07 30.3 17.1 0.0012 18.6 3.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.2 EFE43939.1 - 4.7e-06 26.4 12.7 0.00055 20.0 2.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 EFE43939.1 - 9.8e-06 25.8 10.0 0.0011 19.2 7.7 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_18 PF13746.1 EFE43939.1 - 6.7e-05 23.2 9.8 0.015 15.7 0.6 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.1 EFE43939.1 - 0.0092 16.3 15.4 0.28 11.5 3.2 2.7 2 1 1 3 3 3 2 4Fe-4S single cluster domain Fer4_15 PF13459.1 EFE43939.1 - 0.017 15.7 13.5 0.2 12.2 1.0 2.8 2 1 0 2 2 2 0 4Fe-4S single cluster domain Fer4_3 PF12798.2 EFE43939.1 - 0.065 13.8 16.9 0.15 12.6 2.4 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.5 EFE43939.1 - 0.14 12.2 4.9 0.29 11.2 0.1 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain PCDO_beta_N PF12391.3 EFE43939.1 - 1.5 8.2 6.0 0.98 8.9 1.0 2.4 2 0 0 2 2 2 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal SURF6 PF04935.7 EFE43940.1 - 1.5e-50 171.4 35.1 1.5e-50 171.4 24.4 4.0 2 1 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.1 EFE43940.1 - 3.7e-05 23.7 5.6 3.7e-05 23.7 3.9 8.7 7 2 0 8 8 8 1 60S ribosome biogenesis protein Rrp14 Rick_17kDa_Anti PF05433.10 EFE43941.1 - 0.0025 17.4 15.8 0.0025 17.4 11.0 2.9 3 1 0 3 3 3 1 Glycine zipper 2TM domain Acyl_transf_3 PF01757.17 EFE43943.1 - 3.4e-39 134.6 32.1 4.4e-39 134.2 22.2 1.1 1 0 0 1 1 1 1 Acyltransferase family Gly_transf_sug PF04488.10 EFE43944.1 - 8.4e-12 45.3 0.2 1.8e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Ribosomal_S2 PF00318.15 EFE43945.1 - 3.2e-49 167.0 0.0 6.8e-49 165.9 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S2 SOBP PF15279.1 EFE43946.1 - 0.00089 19.7 1.7 0.0014 19.0 1.2 1.3 1 0 0 1 1 1 1 Sine oculis-binding protein IMS_C PF11799.3 EFE43946.1 - 0.12 12.3 0.0 0.53 10.2 0.0 2.0 2 0 0 2 2 2 0 impB/mucB/samB family C-terminal domain Zn_clus PF00172.13 EFE43946.1 - 0.33 10.9 5.1 0.13 12.1 1.3 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.22 EFE43947.1 - 2.1e-56 187.6 0.1 2.2e-19 68.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein GTP_EFTU PF00009.22 EFE43948.1 - 4e-37 127.4 4.2 2.8e-36 124.7 2.9 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EFE43948.1 - 3.2e-26 91.3 2.2 5.4e-26 90.6 0.6 2.1 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EFE43948.1 - 7.4e-13 48.4 0.7 3e-06 27.2 0.0 2.8 2 0 0 2 2 2 2 Elongation factor Tu domain 2 IF2_N PF04760.10 EFE43948.1 - 3.1e-09 36.3 0.0 4.7e-08 32.5 0.0 2.7 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.18 EFE43948.1 - 4.7e-08 32.9 0.1 1e-07 31.9 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE43948.1 - 2.1e-06 28.1 0.1 5.9e-06 26.7 0.1 1.8 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE43948.1 - 6.8e-05 22.1 0.0 0.00013 21.2 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFE43948.1 - 0.00011 21.4 0.1 0.00027 20.2 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 EFE43948.1 - 0.0037 17.0 0.2 2.2 8.0 0.0 2.9 1 1 1 2 2 2 2 Dynamin family PduV-EutP PF10662.4 EFE43948.1 - 0.0065 15.9 0.1 0.018 14.5 0.1 1.7 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.17 EFE43948.1 - 0.015 14.7 0.2 0.028 13.8 0.1 1.4 1 0 0 1 1 1 0 Ras family FeoB_N PF02421.13 EFE43948.1 - 0.015 14.5 0.5 0.051 12.8 0.3 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B GTP_EFTU_D4 PF14578.1 EFE43948.1 - 0.088 12.4 4.4 0.58 9.8 0.1 3.3 3 1 0 3 3 3 0 Elongation factor Tu domain 4 HNH PF01844.18 EFE43950.1 - 0.00042 20.1 2.4 0.00078 19.2 1.7 1.5 1 0 0 1 1 1 1 HNH endonuclease DUF1364 PF07102.7 EFE43950.1 - 0.056 13.3 0.2 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1364) Ceramidase_alk PF04734.8 EFE43952.1 - 5.3e-268 890.4 0.0 6.1e-268 890.2 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase BCAS2 PF05700.6 EFE43953.1 - 9.3e-42 142.9 9.8 3.1e-25 88.9 2.4 2.0 1 1 1 2 2 2 2 Breast carcinoma amplified sequence 2 (BCAS2) DUF1206 PF06724.6 EFE43954.1 - 0.24 11.2 2.7 0.28 10.9 0.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) Kelch_5 PF13854.1 EFE43955.1 - 2.2e-19 68.9 10.9 2.3e-09 37.0 0.1 4.7 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.1 EFE43955.1 - 1.8e-12 46.8 12.1 0.0068 16.1 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 EFE43955.1 - 4e-11 42.7 8.1 2e-05 24.5 0.0 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 EFE43955.1 - 2.2e-10 40.2 6.9 0.0013 18.7 0.1 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 EFE43955.1 - 1.5e-06 27.7 1.7 0.13 12.0 0.1 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 EFE43955.1 - 0.0045 16.5 7.0 1.8 8.1 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Snf7 PF03357.16 EFE43956.1 - 6.9e-32 110.1 18.4 6.9e-32 110.1 12.8 2.0 1 1 1 2 2 2 1 Snf7 NuA4 PF09340.5 EFE43956.1 - 1.6 8.4 4.5 0.46 10.1 0.3 2.4 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 Allexi_40kDa PF05549.6 EFE43956.1 - 6 6.0 8.6 8.3 5.6 5.3 1.7 1 1 0 1 1 1 0 Allexivirus 40kDa protein Fork_head PF00250.13 EFE43957.1 - 8.1e-17 61.0 0.1 1.5e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 EFE43957.1 - 0.00051 20.1 0.0 0.00098 19.1 0.0 1.4 1 0 0 1 1 1 1 FHA domain 2OG-FeII_Oxy_3 PF13640.1 EFE43958.1 - 1.5e-10 41.4 0.0 2.4e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 EFE43958.1 - 1.8e-07 30.6 0.0 4.4e-07 29.4 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 EFE43958.1 - 8.9e-05 22.7 0.0 0.00015 22.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily cNMP_binding PF00027.24 EFE43959.1 - 3.2e-41 139.0 0.0 7.5e-20 70.5 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF4629 PF15442.1 EFE43960.1 - 0.29 11.2 5.7 0.36 10.9 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4629) Uds1 PF15456.1 EFE43960.1 - 0.43 10.5 2.8 0.74 9.8 1.9 1.3 1 0 0 1 1 1 0 Up-regulated During Septation CDC45 PF02724.9 EFE43960.1 - 1.7 6.5 8.1 2 6.3 5.6 1.0 1 0 0 1 1 1 0 CDC45-like protein NAM-associated PF14303.1 EFE43960.1 - 3.3 8.0 8.0 2.5 8.4 4.9 1.3 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain GHBP PF12772.2 EFE43962.1 - 0.048 13.0 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Growth hormone receptor binding DUF4058 PF13267.1 EFE43962.1 - 0.079 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) APH PF01636.18 EFE43963.1 - 0.0077 15.9 0.0 0.015 15.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF106 PF01956.11 EFE43964.1 - 0.018 14.5 0.1 0.019 14.4 0.0 1.0 1 0 0 1 1 1 0 Integral membrane protein DUF106 TMEMspv1-c74-12 PF11044.3 EFE43964.1 - 0.025 14.1 0.1 0.041 13.4 0.1 1.4 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF1310 PF07006.6 EFE43964.1 - 0.026 14.0 0.7 0.031 13.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) DUF1183 PF06682.7 EFE43964.1 - 0.044 13.3 0.0 0.053 13.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) SpoIIIAH PF12685.2 EFE43964.1 - 0.046 13.2 0.0 0.048 13.1 0.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF4366 PF14283.1 EFE43964.1 - 0.071 12.5 0.1 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) GRP PF07172.6 EFE43964.1 - 0.073 13.5 0.1 0.092 13.2 0.0 1.2 1 0 0 1 1 1 0 Glycine rich protein family Chordopox_A13L PF05961.6 EFE43964.1 - 0.12 12.2 1.2 0.19 11.7 0.8 1.6 1 1 0 1 1 1 0 Chordopoxvirus A13L protein DUF4307 PF14155.1 EFE43964.1 - 0.15 11.8 6.1 1.7 8.4 1.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) DUF1768 PF08719.6 EFE43965.1 - 1e-50 171.5 0.0 1.2e-50 171.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Pkinase PF00069.20 EFE43966.1 - 2.6e-23 82.5 0.0 3.8e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE43966.1 - 6.6e-10 38.4 0.0 1e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Plasmid_Txe PF06769.8 EFE43966.1 - 0.057 13.2 0.0 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 Plasmid encoded toxin Txe MFS_1 PF07690.11 EFE43967.1 - 8.7e-33 113.4 48.5 2.7e-32 111.8 17.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE43967.1 - 5.2e-31 107.7 25.8 1.1e-29 103.3 17.9 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter PAP2 PF01569.16 EFE43968.1 - 9e-13 48.0 5.6 1.1e-12 47.7 3.9 1.1 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.1 EFE43968.1 - 9.4e-07 28.5 3.9 1.6e-06 27.7 2.7 1.4 1 1 0 1 1 1 1 PAP2 superfamily LCAT PF02450.10 EFE43969.1 - 7.5e-93 311.5 0.0 9.5e-93 311.2 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 EFE43969.1 - 0.00083 19.3 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_2 PF01674.13 EFE43969.1 - 0.0043 16.3 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 2) Abhydrolase_5 PF12695.2 EFE43969.1 - 0.0058 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family HutD PF05962.6 EFE43969.1 - 0.094 12.4 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 HutD AP_endonuc_2 PF01261.19 EFE43969.1 - 0.094 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel PGAP1 PF07819.8 EFE43969.1 - 0.16 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Acetyltransf_1 PF00583.19 EFE43970.1 - 1.7e-18 66.3 0.0 2.5e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE43970.1 - 6.2e-12 45.5 0.0 9.5e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE43970.1 - 2e-11 43.5 0.0 3.1e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EFE43970.1 - 4.4e-11 42.9 0.0 5.5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFE43970.1 - 9.9e-09 35.4 0.0 1.8e-08 34.6 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFE43970.1 - 4.9e-08 32.9 0.0 7.9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE43970.1 - 2.4e-06 27.4 0.1 6.1e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EFE43970.1 - 0.00013 21.9 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFE43970.1 - 0.00095 19.0 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.1 EFE43970.1 - 0.081 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Mis14 PF08641.7 EFE43973.1 - 4.2e-23 81.9 6.5 4.2e-23 81.9 4.5 1.7 2 0 0 2 2 2 1 Kinetochore protein Mis14 like UPF0515 PF15135.1 EFE43973.1 - 0.031 13.3 1.2 0.047 12.7 0.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 Mak16 PF04874.9 EFE43973.1 - 0.041 13.9 9.2 0.11 12.5 6.4 1.8 1 0 0 1 1 1 0 Mak16 protein C-terminal region CDC45 PF02724.9 EFE43973.1 - 0.21 9.5 3.8 0.28 9.1 2.6 1.1 1 0 0 1 1 1 0 CDC45-like protein CRAL_TRIO PF00650.15 EFE43974.1 - 8.8e-39 132.5 0.0 1.2e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFE43974.1 - 2.6e-08 33.8 0.4 2.6e-08 33.8 0.3 3.0 3 0 0 3 3 3 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EFE43974.1 - 3.5e-06 26.9 0.0 7.8e-06 25.8 0.0 1.5 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain BSP_II PF05432.6 EFE43974.1 - 0.02 14.1 10.1 0.029 13.6 7.0 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RR_TM4-6 PF06459.7 EFE43974.1 - 0.2 11.5 6.7 0.29 10.9 4.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.5 EFE43974.1 - 2.8 7.9 12.7 5.5 6.9 8.8 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Daxx PF03344.10 EFE43974.1 - 7.7 4.8 11.1 11 4.3 7.7 1.1 1 0 0 1 1 1 0 Daxx Family RAB3GAP2_N PF14655.1 EFE43975.1 - 0.15 11.0 0.7 0.17 10.8 0.3 1.2 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus CRT10 PF08728.5 EFE43975.1 - 0.9 7.4 4.0 0.95 7.3 2.8 1.0 1 0 0 1 1 1 0 CRT10 RasGAP PF00616.14 EFE43976.1 - 3.2e-54 183.6 0.2 9.6e-54 182.0 0.0 1.9 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.10 EFE43976.1 - 2.3e-32 111.6 5.8 2.3e-32 111.6 4.0 2.4 2 0 0 2 2 2 1 RasGAP C-terminus DUF1647 PF07801.6 EFE43976.1 - 0.3 10.5 3.9 0.12 11.8 0.2 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1647) PHD PF00628.24 EFE43977.1 - 5.3e-11 42.0 8.0 1.2e-10 40.8 5.5 1.7 1 0 0 1 1 1 1 PHD-finger Choline_kinase PF01633.15 EFE43977.1 - 0.078 12.5 0.3 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase Chorismate_synt PF01264.16 EFE43978.1 - 1.6e-117 391.8 0.0 1.8e-117 391.6 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ima1_N PF09779.4 EFE43979.1 - 4.3e-43 146.9 8.2 4.3e-43 146.9 5.7 1.8 2 0 0 2 2 2 1 Ima1 N-terminal domain OrfB_Zn_ribbon PF07282.6 EFE43979.1 - 1.5 8.5 4.1 0.49 10.0 0.6 1.9 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.2 EFE43979.1 - 3.9 7.3 10.9 0.37 10.6 2.8 2.6 3 0 0 3 3 3 0 Transposase zinc-ribbon domain DZR PF12773.2 EFE43979.1 - 7.3 6.4 7.7 19 5.1 0.4 2.7 2 1 0 2 2 2 0 Double zinc ribbon Alg14 PF08660.6 EFE43980.1 - 9.1e-49 165.7 0.0 1.2e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like DUF2207 PF09972.4 EFE43981.1 - 0.0032 16.1 0.3 0.0038 15.8 0.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) GoLoco PF02188.12 EFE43981.1 - 0.17 11.2 1.3 0.38 10.1 0.9 1.6 1 0 0 1 1 1 0 GoLoco motif ABC2_membrane_3 PF12698.2 EFE43981.1 - 1.4 7.8 13.0 2 7.3 9.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Herpes_glycop_D PF01537.12 EFE43982.1 - 0.025 14.5 0.3 0.046 13.6 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus glycoprotein D/GG/GX domain Kelch_4 PF13418.1 EFE43985.1 - 1.9e-05 24.3 8.7 0.021 14.5 0.1 4.9 6 1 0 6 6 6 2 Galactose oxidase, central domain SKG6 PF08693.5 EFE43985.1 - 8.3e-05 21.8 3.7 0.00017 20.8 2.5 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.7 EFE43985.1 - 0.00015 21.2 0.0 0.00036 19.9 0.0 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Kelch_5 PF13854.1 EFE43985.1 - 0.00021 21.1 0.0 0.032 14.1 0.0 3.0 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.1 EFE43985.1 - 0.0003 20.8 0.6 1.2 9.3 0.0 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.1 EFE43985.1 - 0.00036 20.6 1.6 5.7 7.2 0.1 4.4 4 0 0 4 4 4 1 Galactose oxidase, central domain DUF3246 PF11596.3 EFE43985.1 - 0.00058 19.2 0.9 0.0015 17.8 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) Kelch_2 PF07646.10 EFE43985.1 - 0.0055 16.4 3.0 1.9 8.3 0.0 4.1 3 0 0 3 3 3 2 Kelch motif BPL_LplA_LipB PF03099.14 EFE43986.1 - 2.8e-10 40.2 0.0 7.3e-10 38.9 0.0 1.7 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Peptidase_M36 PF02128.10 EFE43987.1 - 2.2e-159 530.3 13.7 3.1e-159 529.8 9.5 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.8 EFE43987.1 - 1.4e-11 43.7 2.9 2.7e-11 42.7 2.0 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.10 EFE43987.1 - 0.00011 22.0 0.0 0.00034 20.4 0.0 1.8 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain AMP-binding PF00501.23 EFE43989.1 - 2.7e-71 240.1 0.0 4.3e-71 239.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE43989.1 - 6.5e-11 43.0 0.2 1.6e-10 41.7 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Lyase_1 PF00206.15 EFE43990.1 - 4.6e-84 282.2 0.0 7.9e-84 281.5 0.0 1.4 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 EFE43990.1 - 1.6e-26 92.1 0.1 4.3e-26 90.7 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal PEX11 PF05648.9 EFE43991.1 - 1.6e-52 177.9 2.5 1.2e-45 155.5 0.0 2.0 1 1 1 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Amidase PF01425.16 EFE43992.1 - 1.6e-66 225.0 0.1 1e-64 219.0 0.1 2.0 1 1 0 1 1 1 1 Amidase ARID PF01388.16 EFE43993.1 - 5.1e-06 26.2 0.0 1.1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain CSF-1 PF05337.6 EFE43993.1 - 0.038 13.3 0.1 0.074 12.3 0.1 1.4 1 0 0 1 1 1 0 Macrophage colony stimulating factor-1 (CSF-1) DUF4066 PF13278.1 EFE43994.1 - 3.9e-11 42.4 0.0 5.8e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 EFE43994.1 - 1.6e-09 37.4 0.0 2.2e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family ArfGap PF01412.13 EFE43995.1 - 7.2e-10 38.6 1.1 7.8e-09 35.3 0.8 2.1 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf SelR PF01641.13 EFE43996.1 - 7.9e-50 167.7 0.1 1.1e-49 167.2 0.1 1.2 1 0 0 1 1 1 1 SelR domain NinF PF05810.7 EFE43996.1 - 0.042 13.6 0.0 0.5 10.2 0.0 2.2 2 0 0 2 2 2 0 NinF protein GFA PF04828.9 EFE43996.1 - 0.093 12.6 0.6 5.1 7.1 0.0 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DUF2296 PF10058.4 EFE43996.1 - 0.1 12.3 0.3 1.8 8.3 0.0 2.4 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) DZR PF12773.2 EFE43996.1 - 0.15 11.9 0.9 14 5.6 0.0 2.3 2 0 0 2 2 2 0 Double zinc ribbon TF_Zn_Ribbon PF08271.7 EFE43996.1 - 0.2 11.0 1.7 0.22 10.8 0.2 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding Yippee-Mis18 PF03226.9 EFE43996.1 - 0.21 11.6 1.5 1.5 8.8 1.1 2.1 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-Mss51 PF13824.1 EFE43996.1 - 2.4 8.0 4.5 8.9 6.2 0.6 2.9 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Smr PF01713.16 EFE43997.1 - 5.8e-11 42.4 0.1 1.9e-10 40.8 0.1 2.0 1 0 0 1 1 1 1 Smr domain DUF1771 PF08590.5 EFE43997.1 - 9.8e-11 41.5 4.1 3.2e-10 39.8 2.8 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CUE PF02845.11 EFE43997.1 - 1.8e-08 33.7 0.3 1.4e-07 30.8 0.0 2.7 4 0 0 4 4 4 1 CUE domain Miro PF08477.8 EFE43998.1 - 9.2e-37 126.1 0.0 3.8e-19 69.3 0.0 2.3 2 0 0 2 2 2 2 Miro-like protein EF_assoc_2 PF08356.7 EFE43998.1 - 9.5e-35 118.2 0.0 1.8e-34 117.3 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.7 EFE43998.1 - 2e-31 107.0 0.2 3.4e-31 106.3 0.2 1.4 1 0 0 1 1 1 1 EF hand associated Ras PF00071.17 EFE43998.1 - 7.4e-24 83.9 0.0 1.1e-13 50.8 0.0 2.2 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.18 EFE43998.1 - 8.2e-10 38.6 0.0 0.00014 21.7 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_7 PF13499.1 EFE43998.1 - 5.8e-08 32.7 0.1 0.0019 18.3 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EFE43998.1 - 5.8e-08 31.9 0.5 0.022 14.6 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 EFE43998.1 - 9.7e-07 27.6 4.0 0.01 15.0 0.1 3.1 3 0 0 3 3 2 2 EF hand AAA_16 PF13191.1 EFE43998.1 - 2.2e-06 27.8 0.6 0.015 15.3 0.0 2.7 3 0 0 3 3 2 2 AAA ATPase domain AAA_29 PF13555.1 EFE43998.1 - 1.1e-05 24.8 0.0 0.01 15.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain Dynamin_N PF00350.18 EFE43998.1 - 1.3e-05 25.1 0.8 0.77 9.5 0.1 3.9 3 1 1 4 4 4 2 Dynamin family EF-hand_10 PF14788.1 EFE43998.1 - 4e-05 23.1 1.0 0.0092 15.6 0.1 2.4 2 0 0 2 2 2 1 EF hand AAA_22 PF13401.1 EFE43998.1 - 0.0001 22.4 0.0 0.78 9.8 0.0 2.6 2 1 0 2 2 2 2 AAA domain EF-hand_8 PF13833.1 EFE43998.1 - 0.00043 19.8 0.3 0.23 11.0 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair MobB PF03205.9 EFE43998.1 - 0.00063 19.4 0.0 0.24 11.1 0.1 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 EFE43998.1 - 0.0019 17.6 0.0 2.1 7.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 EFE43998.1 - 0.002 18.0 0.0 1 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 EFE43998.1 - 0.0024 17.4 0.2 0.09 12.2 0.0 2.7 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NACHT PF05729.7 EFE43998.1 - 0.0039 16.8 0.1 3.4 7.3 0.0 2.7 2 0 0 2 2 2 1 NACHT domain EF-hand_5 PF13202.1 EFE43998.1 - 0.0047 16.2 6.9 0.12 11.7 0.2 3.0 3 0 0 3 3 2 2 EF hand AAA_33 PF13671.1 EFE43998.1 - 0.005 16.7 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 EFE43998.1 - 0.0052 17.0 0.0 5.2 7.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.17 EFE43998.1 - 0.0074 16.4 0.0 0.96 9.6 0.0 2.6 2 0 0 2 2 2 1 RNA helicase GTP_EFTU PF00009.22 EFE43998.1 - 0.0075 15.7 0.0 5.7 6.3 0.0 3.1 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Septin PF00735.13 EFE43998.1 - 0.0087 15.1 0.0 0.39 9.6 0.1 2.2 2 0 0 2 2 2 1 Septin FtsK_SpoIIIE PF01580.13 EFE43998.1 - 0.0091 15.4 0.1 2.3 7.6 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 EFE43998.1 - 0.01 15.3 0.0 1.4 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_17 PF13207.1 EFE43998.1 - 0.012 16.4 0.0 7.5 7.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EFE43998.1 - 0.016 15.4 0.4 8.5 6.6 0.1 2.9 2 2 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EFE43998.1 - 0.023 14.2 0.1 0.2 11.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 EFE43998.1 - 0.023 14.2 1.8 4.6 6.7 0.0 3.3 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF258 PF03193.11 EFE43998.1 - 0.038 13.1 0.1 1.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ArgK PF03308.11 EFE43998.1 - 0.056 12.2 0.4 2.6 6.7 0.0 2.2 2 0 0 2 2 2 0 ArgK protein DUF815 PF05673.8 EFE43998.1 - 0.056 12.3 0.1 1.8 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) SMC_N PF02463.14 EFE43998.1 - 0.057 12.6 0.5 1.8 7.7 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_5 PF07728.9 EFE43998.1 - 0.083 12.6 0.2 21 4.7 0.0 2.9 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.1 EFE43998.1 - 0.084 13.1 0.1 14 5.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain IIGP PF05049.8 EFE43998.1 - 0.11 11.2 0.6 0.33 9.7 0.1 1.8 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA PF00004.24 EFE43998.1 - 0.15 12.2 0.4 12 6.0 0.1 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.14 EFE43998.1 - 0.16 11.3 1.6 1.8 8.0 0.0 3.0 4 1 0 4 4 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.7 EFE43998.1 - 0.21 10.6 0.0 2.6 7.0 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin MCM PF00493.18 EFE43998.1 - 0.23 10.2 0.0 5.9 5.5 0.0 2.2 2 0 0 2 2 2 0 MCM2/3/5 family DUF500 PF04366.7 EFE43999.1 - 4.1e-45 152.2 0.1 2.2e-44 149.9 0.2 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF500) SH3_1 PF00018.23 EFE43999.1 - 2.6e-13 49.1 0.1 1.1e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 EFE43999.1 - 3.5e-13 48.8 0.0 7.4e-13 47.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EFE43999.1 - 1.1e-11 44.0 0.1 1.9e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Zds_C PF08632.5 EFE44000.1 - 1.8e-31 107.3 3.9 1.9e-30 103.9 1.2 2.4 2 0 0 2 2 2 2 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF2422 PF10337.4 EFE44001.1 - 2.6e-25 89.1 0.0 2.6e-25 89.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2422) FUSC_2 PF13515.1 EFE44001.1 - 3.7e-06 26.8 12.0 3.7e-06 26.8 8.3 2.1 2 1 0 2 2 2 1 Fusaric acid resistance protein-like DUF939 PF06081.6 EFE44001.1 - 0.91 9.3 17.1 0.029 14.2 6.5 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF939) DUF2421 PF10334.4 EFE44002.1 - 6.3e-05 22.6 0.0 0.0002 21.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) WD40 PF00400.27 EFE44003.1 - 3.5e-06 26.6 0.0 0.04 13.7 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF1273 PF06908.6 EFE44003.1 - 0.073 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1273) Arf PF00025.16 EFE44004.1 - 2.9e-65 218.7 0.0 2.6e-56 189.5 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFE44004.1 - 5.2e-11 42.1 0.0 7.1e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 EFE44004.1 - 1e-09 37.9 0.0 1.4e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 EFE44004.1 - 2.3e-09 36.4 1.0 8.9e-06 24.6 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 EFE44004.1 - 2e-08 33.7 0.0 2.3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE44004.1 - 0.00015 22.2 0.0 0.00024 21.5 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFE44004.1 - 0.0002 21.2 0.0 0.00034 20.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 EFE44004.1 - 0.042 12.9 0.1 0.062 12.3 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Pyr_redox_3 PF13738.1 EFE44005.1 - 6.1e-23 81.9 0.0 1e-22 81.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFE44005.1 - 7.9e-15 54.0 0.0 8.3e-13 47.3 0.0 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 EFE44005.1 - 3.1e-10 39.5 0.0 4e-07 29.2 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EFE44005.1 - 8.2e-09 35.6 0.0 3.1e-07 30.4 0.0 2.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFE44005.1 - 3.2e-06 26.3 0.1 1.7e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.1 EFE44005.1 - 0.00021 21.1 0.0 0.023 14.4 0.0 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFE44005.1 - 0.00023 21.1 0.3 0.00096 19.1 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.1 EFE44005.1 - 0.00082 19.5 0.0 0.44 10.8 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.7 EFE44005.1 - 0.0045 15.9 0.1 0.16 10.8 0.0 2.8 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox PF00070.22 EFE44005.1 - 0.012 15.9 1.9 0.54 10.7 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE44005.1 - 0.14 10.5 2.4 2 6.8 0.1 2.9 3 0 0 3 3 3 0 HI0933-like protein DUF4147 PF13660.1 EFE44005.1 - 0.18 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) FAD_binding_2 PF00890.19 EFE44005.1 - 0.31 9.8 1.1 14 4.4 0.1 2.4 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.19 EFE44005.1 - 0.34 9.7 2.1 0.49 9.2 0.1 2.3 4 0 0 4 4 4 0 FAD dependent oxidoreductase F-box-like PF12937.2 EFE44006.1 - 9.7e-06 25.2 2.6 4.4e-05 23.1 1.8 2.1 1 1 0 1 1 1 1 F-box-like F-box PF00646.28 EFE44006.1 - 4 7.2 5.2 6.9 6.4 0.4 2.4 2 0 0 2 2 2 0 F-box domain TPR_11 PF13414.1 EFE44008.1 - 6.3e-44 147.4 14.1 7.5e-17 60.7 0.7 5.8 3 2 1 5 5 5 4 TPR repeat TPR_1 PF00515.23 EFE44008.1 - 2e-35 118.9 7.9 2.1e-06 27.0 0.1 7.5 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_2 PF07719.12 EFE44008.1 - 1.6e-33 111.8 9.2 4.3e-06 26.2 0.0 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat DnaJ PF00226.26 EFE44008.1 - 5.1e-27 93.3 5.4 6.3e-27 93.0 0.8 3.2 4 0 0 4 4 4 1 DnaJ domain TPR_19 PF14559.1 EFE44008.1 - 4.3e-24 84.6 9.1 2.6e-06 27.6 0.0 5.7 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.1 EFE44008.1 - 2.5e-23 80.4 10.6 0.00023 21.5 0.0 9.1 3 3 6 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.1 EFE44008.1 - 1e-21 76.9 18.0 4.1e-06 27.2 1.3 6.0 4 2 2 6 6 5 5 Tetratricopeptide repeat TPR_17 PF13431.1 EFE44008.1 - 1.3e-18 65.5 9.0 0.0033 17.5 0.1 7.1 6 0 0 6 6 6 5 Tetratricopeptide repeat Apc3 PF12895.2 EFE44008.1 - 7e-17 61.3 2.5 9.3e-06 25.6 0.1 3.9 2 2 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EFE44008.1 - 3e-15 55.9 13.7 2.1e-05 24.3 0.4 5.5 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 EFE44008.1 - 1.1e-14 53.0 8.0 0.022 14.5 0.0 7.4 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_9 PF13371.1 EFE44008.1 - 9.2e-13 47.8 4.6 0.0057 16.4 0.0 5.0 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFE44008.1 - 1.1e-12 46.7 12.5 0.0068 16.1 0.0 7.7 6 1 2 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.1 EFE44008.1 - 2.3e-09 37.0 12.7 0.0011 19.2 0.0 7.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_15 PF13429.1 EFE44008.1 - 9.4e-08 31.4 3.3 0.037 13.0 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.12 EFE44008.1 - 2.5e-06 27.8 2.5 0.00052 20.3 0.3 3.7 3 1 0 3 3 3 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.1 EFE44008.1 - 9.8e-06 25.3 4.1 1.7 8.6 0.0 4.9 2 1 2 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.5 EFE44008.1 - 0.00025 19.9 0.0 0.12 11.1 0.0 2.6 2 1 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.1 EFE44008.1 - 0.0004 20.4 8.8 4.3 7.5 0.1 5.2 3 2 1 5 5 5 1 Tetratricopeptide repeat Med3 PF11593.3 EFE44008.1 - 0.00088 18.6 7.1 0.00088 18.6 4.9 2.6 2 1 0 3 3 1 1 Mediator complex subunit 3 fungal Coatomer_E PF04733.9 EFE44008.1 - 0.0019 17.4 0.3 3.5 6.7 0.0 3.2 3 0 0 3 3 3 1 Coatomer epsilon subunit TPR_10 PF13374.1 EFE44008.1 - 0.0024 17.7 14.2 0.88 9.5 0.0 6.1 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_4 PF07721.9 EFE44008.1 - 0.016 15.5 10.6 0.36 11.3 0.0 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat MIT PF04212.13 EFE44008.1 - 0.053 13.4 4.0 0.89 9.4 0.1 3.9 2 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.4 EFE44008.1 - 0.16 11.2 2.5 1.1e+02 2.1 0.0 4.5 4 0 0 4 4 4 0 SHNi-TPR RPN7 PF10602.4 EFE44008.1 - 3.3 7.0 6.7 3.6 6.9 0.0 3.8 3 3 1 4 4 4 0 26S proteasome subunit RPN7 DUF3729 PF12526.3 EFE44009.1 - 0.19 13.0 3.6 1.1e+02 4.1 3.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3729) Protoglobin PF11563.3 EFE44012.1 - 2e-50 170.5 0.0 2.4e-50 170.2 0.0 1.1 1 0 0 1 1 1 1 Protoglobin DUF1499 PF07386.6 EFE44012.1 - 0.074 13.2 0.0 0.13 12.4 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1499) CN_hydrolase PF00795.17 EFE44013.1 - 1.4e-25 89.6 0.0 4.1e-25 88.2 0.0 1.7 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.12 EFE44013.1 - 3.9e-25 88.1 0.0 8.1e-25 87.1 0.0 1.5 1 1 0 1 1 1 1 NAD synthase Pkinase PF00069.20 EFE44014.1 - 2.3e-51 174.4 0.0 3.9e-51 173.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44014.1 - 1.6e-30 106.0 0.0 2.7e-30 105.3 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44014.1 - 2.8e-09 36.3 0.0 4.1e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFE44014.1 - 0.16 10.9 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PBP1_TM PF14812.1 EFE44015.1 - 0.036 14.3 2.7 0.036 14.3 1.9 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.9 EFE44015.1 - 0.18 9.7 5.6 0.22 9.4 3.9 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.5 EFE44015.1 - 2.5 8.4 7.1 0.42 10.8 1.7 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TT_ORF2 PF02957.10 EFE44015.1 - 4.4 8.0 10.7 0.85 10.3 0.2 2.3 2 0 0 2 2 2 0 TT viral ORF2 Sec39 PF08314.6 EFE44016.1 - 3.3e-192 640.2 0.0 3.7e-192 640.0 0.0 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 DUF3535 PF12054.3 EFE44017.1 - 1.1e-149 498.8 0.0 1.1e-148 495.4 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 EFE44017.1 - 7.7e-72 241.5 0.0 1.4e-71 240.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.17 EFE44017.1 - 6.7e-17 59.9 11.6 0.0051 16.7 0.1 10.0 11 0 0 11 11 11 4 HEAT repeat Helicase_C PF00271.26 EFE44017.1 - 2.2e-14 53.0 0.0 6.5e-14 51.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_2 PF13646.1 EFE44017.1 - 1.3e-06 28.5 14.1 0.01 16.1 0.0 8.0 8 2 1 9 9 9 1 HEAT repeats HEAT_EZ PF13513.1 EFE44017.1 - 2.5e-06 27.7 5.8 1.5 9.4 0.0 7.6 7 0 0 7 7 7 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFE44017.1 - 3.8e-06 27.2 0.2 0.13 12.6 0.0 4.1 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 EFE44017.1 - 0.00019 20.9 0.0 0.075 12.3 0.0 3.9 3 1 1 4 4 4 1 CLASP N terminal Erythro_esteras PF05139.9 EFE44019.1 - 3.5e-110 368.4 1.1 1.2e-103 347.0 0.1 2.1 1 1 1 2 2 2 2 Erythromycin esterase Scs3p PF10261.4 EFE44021.1 - 1.1e-58 198.1 0.7 1.4e-58 197.7 0.5 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Nexin_C PF08628.7 EFE44022.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Sorting nexin C terminal Med19 PF10278.4 EFE44023.1 - 1.3 8.6 12.6 1.3 8.6 8.7 1.0 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3886 PF13025.1 EFE44023.1 - 1.6 8.7 12.0 1.7 8.6 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) DUF2956 PF11169.3 EFE44023.1 - 7 6.6 8.0 7.6 6.5 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) tRNA-synt_1e PF01406.14 EFE44024.1 - 1.7e-15 56.9 0.0 2e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF368 PF04018.8 EFE44024.1 - 0.061 12.5 0.6 0.096 11.8 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF368) tRNA-synt_1c PF00749.16 EFE44024.1 - 0.16 10.5 0.0 0.27 9.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain RNase_H2_suC PF08615.6 EFE44025.1 - 0.0054 16.5 0.1 0.0063 16.3 0.1 1.2 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DASH_Spc19 PF08287.6 EFE44025.1 - 0.26 10.9 8.4 0.059 12.9 3.2 1.7 2 0 0 2 2 2 0 Spc19 Uds1 PF15456.1 EFE44025.1 - 0.45 10.5 5.9 1.1 9.3 2.5 2.4 2 1 0 2 2 2 0 Up-regulated During Septation APH PF01636.18 EFE44026.1 - 1.6e-08 34.5 0.0 1.3e-07 31.5 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family DASH_Spc19 PF08287.6 EFE44026.1 - 0.033 13.8 1.5 0.071 12.7 1.0 1.5 1 0 0 1 1 1 0 Spc19 HipA_N PF07805.7 EFE44026.1 - 0.043 14.0 0.0 1.3 9.3 0.0 2.5 1 1 1 2 2 2 0 HipA-like N-terminal domain RNase_H2_suC PF08615.6 EFE44026.1 - 0.12 12.2 0.1 0.12 12.2 0.1 1.9 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Glyco_hydro_3 PF00933.16 EFE44027.1 - 4.9e-94 314.6 0.0 6.9e-94 314.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFE44027.1 - 1.4e-58 198.1 0.3 7.3e-58 195.7 0.2 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFE44027.1 - 1.6e-11 43.9 0.0 3.1e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_47 PF01532.15 EFE44028.1 - 2.9e-174 580.0 0.0 3.4e-174 579.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF1680 PF07944.7 EFE44028.1 - 0.0011 17.3 0.0 0.071 11.3 0.0 2.2 2 0 0 2 2 2 2 Putative glycosyl hydrolase of unknown function (DUF1680) SKG6 PF08693.5 EFE44029.1 - 0.00019 20.6 0.1 0.00044 19.4 0.1 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4622 PF15415.1 EFE44029.1 - 0.0098 14.7 0.0 0.014 14.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4622) RNA_polI_A34 PF08208.6 EFE44030.1 - 0.0026 17.4 7.7 0.07 12.7 0.0 2.2 2 0 0 2 2 2 2 DNA-directed RNA polymerase I subunit RPA34.5 DUF3325 PF11804.3 EFE44030.1 - 0.0034 17.2 0.7 0.0054 16.6 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3325) RNA_pol_Rpc4 PF05132.9 EFE44030.1 - 0.035 14.0 1.0 1.2 9.1 0.2 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 GAGA_bind PF06217.7 EFE44030.1 - 0.63 9.9 5.9 1.7 8.5 0.5 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family ATP-synt_E PF05680.7 EFE44030.1 - 1 9.3 8.6 2.1 8.3 2.2 2.2 2 0 0 2 2 2 0 ATP synthase E chain BLVR PF06375.6 EFE44030.1 - 1.1 9.0 12.7 0.91 9.3 2.1 2.1 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) Peptidase_S49_N PF08496.5 EFE44030.1 - 3.6 7.3 9.8 1.8 8.3 0.7 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Tombus_movement PF05318.7 EFE44030.1 - 6.3 7.5 11.4 7.6 7.2 1.7 2.2 2 0 0 2 2 2 0 Tombusvirus movement protein Fungal_trans PF04082.13 EFE44031.1 - 6e-24 84.3 0.0 1.6e-23 82.8 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE44031.1 - 5.4e-09 35.8 10.8 9.6e-09 35.0 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP-synt_8 PF00895.15 EFE44032.1 - 0.48 10.6 2.6 2.1 8.6 0.5 2.2 2 0 0 2 2 2 0 ATP synthase protein 8 CIMR PF00878.13 EFE44033.1 - 6.8e-08 32.3 0.1 0.00032 20.4 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat RNase_H2_suC PF08615.6 EFE44033.1 - 0.062 13.1 1.0 0.12 12.1 0.7 1.6 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Nop14 PF04147.7 EFE44033.1 - 0.2 9.5 3.3 0.2 9.5 2.3 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 EFE44033.1 - 1.4 6.8 6.4 2 6.3 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein ERG4_ERG24 PF01222.12 EFE44034.1 - 3.1e-128 427.9 2.4 3.4e-128 427.8 1.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 EFE44034.1 - 0.00015 21.1 1.5 0.00039 19.7 0.3 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1295) A_deamin PF02137.13 EFE44035.1 - 2.8e-44 151.8 0.0 4.8e-43 147.7 0.0 2.0 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain SF3b10 PF07189.6 EFE44036.1 - 3.5e-33 113.2 0.0 7.8e-33 112.1 0.0 1.6 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) IBR PF01485.16 EFE44038.1 - 5.6e-13 48.5 38.2 1.6e-07 31.0 6.4 3.3 3 0 0 3 3 3 3 IBR domain XPG_I_2 PF12813.2 EFE44039.1 - 3.8e-71 239.4 0.0 5.5e-71 238.9 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing Inositol_P PF00459.20 EFE44040.1 - 6.7e-57 192.8 0.0 8.1e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF676 PF05057.9 EFE44041.1 - 2.6e-37 128.2 0.0 1e-35 123.0 0.0 2.8 1 1 0 1 1 1 1 Putative serine esterase (DUF676) DAGK_cat PF00781.19 EFE44041.1 - 8.7e-12 44.6 0.0 1.9e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Abhydrolase_5 PF12695.2 EFE44041.1 - 0.0023 17.6 0.0 0.0074 16.0 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 EFE44041.1 - 0.0043 16.6 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 Lipase (class 3) PGAP1 PF07819.8 EFE44041.1 - 0.092 12.3 0.0 0.29 10.6 0.0 1.8 1 0 0 1 1 1 0 PGAP1-like protein DUF915 PF06028.6 EFE44041.1 - 0.23 10.4 0.1 0.41 9.6 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) NCA2 PF08637.5 EFE44043.1 - 1.2e-79 267.2 0.0 4.1e-79 265.4 0.0 1.7 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 Ras PF00071.17 EFE44043.1 - 1.6e-63 212.8 0.1 2.8e-63 212.1 0.1 1.4 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE44043.1 - 1e-17 64.6 0.0 2.7e-17 63.3 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE44043.1 - 1.8e-12 46.8 0.1 3.3e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFE44043.1 - 5.6e-06 25.6 0.0 9.6e-06 24.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EFE44043.1 - 2.6e-05 23.7 0.1 6.1e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Dicty_REP PF05086.7 EFE44043.1 - 0.075 10.7 1.8 0.12 10.1 1.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FA_hydroxylase PF04116.8 EFE44045.1 - 2.5e-16 60.1 18.3 3.1e-16 59.7 12.7 1.1 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily AAA PF00004.24 EFE44046.1 - 4.3e-57 191.9 0.0 1.4e-40 138.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFE44046.1 - 6.6e-09 36.0 0.3 0.0014 18.6 0.0 3.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.9 EFE44046.1 - 4.7e-06 26.3 0.5 0.0038 16.9 0.1 3.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFE44046.1 - 8.1e-06 26.0 1.4 0.38 10.9 0.0 3.9 3 1 1 4 4 3 2 AAA domain Bac_DnaA PF00308.13 EFE44046.1 - 3.1e-05 23.7 0.0 0.0074 15.9 0.0 3.2 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_14 PF13173.1 EFE44046.1 - 4.9e-05 23.2 0.0 0.068 13.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.1 EFE44046.1 - 7.2e-05 22.8 0.0 0.27 11.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EFE44046.1 - 9e-05 22.6 0.0 0.2 11.8 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.8 EFE44046.1 - 0.00012 20.9 0.4 0.0017 17.1 0.1 2.2 2 0 0 2 2 2 1 TIP49 C-terminus AAA_17 PF13207.1 EFE44046.1 - 0.00013 22.7 1.6 0.14 12.9 0.0 3.1 3 0 0 3 3 2 1 AAA domain RuvB_N PF05496.7 EFE44046.1 - 0.00016 20.8 0.0 0.029 13.4 0.0 2.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 EFE44046.1 - 0.00033 20.6 0.0 0.0012 18.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.16 EFE44046.1 - 0.0015 17.7 1.7 0.0087 15.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI CDC48_N PF02359.13 EFE44046.1 - 0.0016 18.3 0.0 0.028 14.3 0.0 2.5 1 1 1 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain DUF815 PF05673.8 EFE44046.1 - 0.0016 17.4 0.0 1.1 8.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_25 PF13481.1 EFE44046.1 - 0.0022 17.4 2.7 3.4 7.0 0.1 3.7 2 2 1 3 3 3 2 AAA domain Rad17 PF03215.10 EFE44046.1 - 0.0024 16.6 0.0 0.0073 15.0 0.0 1.8 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein IstB_IS21 PF01695.12 EFE44046.1 - 0.0029 17.0 0.0 0.74 9.2 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein Arch_ATPase PF01637.13 EFE44046.1 - 0.0057 16.3 0.4 2.9 7.5 0.0 3.2 2 1 1 3 3 3 1 Archaeal ATPase NACHT PF05729.7 EFE44046.1 - 0.0098 15.5 1.0 4 7.0 0.1 3.0 3 1 0 3 3 3 1 NACHT domain AAA_30 PF13604.1 EFE44046.1 - 0.015 14.8 1.0 1.7 8.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.20 EFE44046.1 - 0.034 13.6 0.0 1.7 8.1 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Sigma54_activ_2 PF14532.1 EFE44046.1 - 0.07 13.1 0.0 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain MCM PF00493.18 EFE44046.1 - 0.098 11.4 0.0 12 4.6 0.0 2.3 2 0 0 2 2 2 0 MCM2/3/5 family AAA_3 PF07726.6 EFE44046.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 EFE44046.1 - 0.2 11.1 2.9 7.5 6.0 0.5 2.6 2 0 0 2 2 2 0 AAA domain FAT PF02259.18 EFE44047.1 - 2.9e-37 128.4 0.0 1.8e-36 125.8 0.0 2.2 2 0 0 2 2 2 1 FAT domain UME PF08064.8 EFE44047.1 - 2.1e-33 114.4 0.8 1.7e-32 111.5 0.1 3.2 3 0 0 3 3 3 1 UME (NUC010) domain TPR_14 PF13428.1 EFE44047.1 - 0.0018 18.7 0.2 20 6.1 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE44047.1 - 0.064 12.9 3.5 20 4.9 0.0 4.5 4 0 0 4 4 4 0 TPR repeat TPR_19 PF14559.1 EFE44047.1 - 0.19 12.0 1.0 18 5.7 0.0 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat Swi3 PF07962.7 EFE44048.1 - 6.3e-17 60.9 0.0 1e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 RCC1 PF00415.13 EFE44049.1 - 6e-57 189.6 17.3 3.4e-10 39.9 0.1 8.1 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EFE44049.1 - 1.5e-40 135.9 37.5 9.6e-08 31.4 0.9 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RibD_C PF01872.12 EFE44050.1 - 8.5e-29 100.5 0.0 1.6e-28 99.7 0.0 1.5 1 0 0 1 1 1 1 RibD C-terminal domain Nic96 PF04097.9 EFE44051.1 - 3.3e-206 686.1 0.0 6e-187 622.5 0.0 2.0 2 0 0 2 2 2 2 Nup93/Nic96 MFS_1 PF07690.11 EFE44052.1 - 1.9e-26 92.6 81.4 9.5e-16 57.4 32.8 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 EFE44052.1 - 2.8e-07 30.2 2.2 0.00012 21.8 1.6 3.0 2 0 0 2 2 2 2 MFS_1 like family MFS_2 PF13347.1 EFE44052.1 - 0.0043 15.5 31.7 0.011 14.1 11.9 3.1 1 1 2 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.19 EFE44052.1 - 0.0066 15.0 8.3 0.0066 15.0 5.8 4.3 1 1 2 4 4 4 2 Sugar (and other) transporter CRPA PF05745.6 EFE44052.1 - 9.9 5.9 7.0 0.79 9.5 1.2 1.7 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Fungal_trans PF04082.13 EFE44053.1 - 4.5e-10 38.8 1.6 4.7e-10 38.7 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain UPF0561 PF10573.4 EFE44053.1 - 0.17 11.7 0.2 0.41 10.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Peptidase_S10 PF00450.17 EFE44054.1 - 3.8e-27 95.4 0.0 4.6e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.17 EFE44055.1 - 2.6e-46 158.6 0.8 5.3e-46 157.6 0.6 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase Na_Ca_ex PF01699.19 EFE44056.1 - 1.5e-30 105.6 29.1 4.3e-18 65.2 6.9 3.7 5 0 0 5 5 5 2 Sodium/calcium exchanger protein DUF307 PF03733.8 EFE44056.1 - 3.5e-14 52.9 11.3 3.5e-14 52.9 7.9 4.2 5 0 0 5 5 5 1 Domain of unknown function (DUF307) AAA PF00004.24 EFE44057.1 - 1.2e-43 148.4 0.0 1.9e-43 147.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFE44057.1 - 4.6e-08 32.8 0.0 1.1e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFE44057.1 - 9.4e-08 32.1 0.0 1.7e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EFE44057.1 - 4.1e-06 26.8 0.1 1.3e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFE44057.1 - 5.6e-06 26.5 0.1 0.00028 21.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFE44057.1 - 7.2e-05 23.5 0.0 0.00016 22.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFE44057.1 - 8.5e-05 21.6 0.0 0.00015 20.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFE44057.1 - 0.00015 21.4 0.0 0.00032 20.3 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 EFE44057.1 - 0.00038 19.9 0.0 0.00082 18.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 EFE44057.1 - 0.00097 17.9 0.0 0.0018 17.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 EFE44057.1 - 0.0015 18.3 0.0 0.0031 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFE44057.1 - 0.0019 18.1 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFE44057.1 - 0.0026 16.9 0.0 0.0048 16.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_3 PF07726.6 EFE44057.1 - 0.0029 17.2 0.0 0.0081 15.7 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 EFE44057.1 - 0.0042 17.0 0.0 0.0074 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EFE44057.1 - 0.0072 15.5 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI KaiC PF06745.8 EFE44057.1 - 0.0073 15.4 0.0 0.018 14.1 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_18 PF13238.1 EFE44057.1 - 0.0075 16.5 0.0 0.03 14.6 0.0 2.2 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.8 EFE44057.1 - 0.02 13.8 0.0 0.037 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 EFE44057.1 - 0.02 14.3 0.0 0.094 12.1 0.0 2.0 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_25 PF13481.1 EFE44057.1 - 0.022 14.1 0.5 0.082 12.2 0.0 2.1 2 1 1 3 3 2 0 AAA domain PhoH PF02562.11 EFE44057.1 - 0.024 13.8 0.0 0.076 12.2 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.1 EFE44057.1 - 0.024 14.2 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFE44057.1 - 0.032 14.3 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Sigma54_activ_2 PF14532.1 EFE44057.1 - 0.052 13.5 0.0 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 EFE44057.1 - 0.056 12.2 0.0 0.092 11.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.17 EFE44057.1 - 0.087 11.6 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Histone PF00125.19 EFE44057.1 - 0.094 12.8 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 NACHT PF05729.7 EFE44057.1 - 0.12 12.0 0.0 0.59 9.7 0.0 2.0 1 1 0 2 2 2 0 NACHT domain DUF2072 PF09845.4 EFE44057.1 - 0.12 12.3 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Fcf1 PF04900.7 EFE44059.1 - 4.1e-10 39.6 1.0 1e-05 25.5 0.1 2.9 3 0 0 3 3 3 2 Fcf1 WD40 PF00400.27 EFE44060.1 - 3.2e-22 77.5 16.3 1.1e-07 31.3 0.5 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat DUF2098 PF09871.4 EFE44060.1 - 0.22 11.4 9.0 25 4.8 0.0 2.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) RR_TM4-6 PF06459.7 EFE44061.1 - 1.7 8.4 24.3 2.2 8.0 16.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SprA-related PF12118.3 EFE44061.1 - 5.6 6.1 19.0 6.6 5.9 13.2 1.1 1 0 0 1 1 1 0 SprA-related family Peptidase_S64 PF08192.6 EFE44063.1 - 8.8e-06 24.3 0.0 1.8e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 Peptidase family S64 RRN3 PF05327.6 EFE44064.1 - 9.9e-161 535.6 0.0 9.9e-161 535.6 0.0 1.9 1 1 1 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Abhydrolase_3 PF07859.8 EFE44065.1 - 1.3e-40 139.2 0.1 3.6e-31 108.3 0.1 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.23 EFE44065.1 - 6e-11 41.7 0.1 1.2e-10 40.7 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EFE44065.1 - 0.0088 15.8 0.1 0.013 15.2 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 EFE44065.1 - 0.031 13.6 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Chlorophyllase2 PF12740.2 EFE44065.1 - 0.18 10.6 0.0 0.3 9.9 0.0 1.4 1 1 0 1 1 1 0 Chlorophyllase enzyme tRNA-synt_2 PF00152.15 EFE44066.1 - 5.7e-76 255.4 0.0 7.8e-76 255.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.4 EFE44066.1 - 3.2e-19 68.8 0.0 4.8e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2156) tRNA-synt_2d PF01409.15 EFE44066.1 - 0.00035 19.8 0.1 0.65 9.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.20 EFE44066.1 - 0.00044 20.0 0.0 0.00087 19.0 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ank_2 PF12796.2 EFE44067.1 - 9.8e-49 163.6 6.7 5.1e-13 49.1 0.0 5.4 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 EFE44067.1 - 3.5e-27 92.8 7.9 0.0001 21.9 0.0 8.5 7 1 1 8 8 8 6 Ankyrin repeat Ank_3 PF13606.1 EFE44067.1 - 3.2e-22 76.4 1.7 0.0047 17.0 0.0 9.0 9 1 1 10 10 10 4 Ankyrin repeat Ank_4 PF13637.1 EFE44067.1 - 2.5e-18 66.0 4.1 0.00089 19.7 0.0 6.8 3 3 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE44067.1 - 1.9e-14 53.3 5.7 0.00027 21.1 0.0 8.1 4 4 4 8 8 8 4 Ankyrin repeats (many copies) DUF3447 PF11929.3 EFE44067.1 - 0.0042 16.8 0.0 3.3 7.5 0.0 4.3 4 2 1 5 5 5 1 Domain of unknown function (DUF3447) HLH PF00010.21 EFE44069.1 - 4.9e-14 51.7 0.3 4.9e-14 51.7 0.2 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Septin PF00735.13 EFE44070.1 - 4e-08 32.6 0.0 6.7e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Septin HSP90 PF00183.13 EFE44071.1 - 7.9e-255 846.2 32.5 9.6e-255 845.9 22.5 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 EFE44071.1 - 1.9e-11 43.6 0.1 3.4e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EFE44071.1 - 3.3e-10 39.7 0.3 3.3e-10 39.7 0.2 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.4 EFE44071.1 - 0.037 13.8 0.2 0.14 11.9 0.1 2.0 1 0 0 1 1 1 0 Tumour suppressor protein NTF2 PF02136.15 EFE44072.1 - 6e-22 78.2 0.2 9.9e-22 77.5 0.1 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 EFE44072.1 - 2.7e-08 33.3 0.1 4.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE44072.1 - 1.4e-06 28.1 0.0 2.3e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE44072.1 - 2.3e-06 27.3 0.0 4.3e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFE44072.1 - 0.012 15.4 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif ETRAMP PF09716.5 EFE44073.1 - 0.00073 19.4 0.1 1.1 9.2 0.0 2.4 2 0 0 2 2 2 2 Malarial early transcribed membrane protein (ETRAMP) Scs3p PF10261.4 EFE44073.1 - 0.002 17.2 1.4 0.0027 16.7 0.2 1.8 2 1 0 2 2 2 1 Inositol phospholipid synthesis and fat-storage-inducing TM DUF3357 PF11837.3 EFE44073.1 - 0.0039 17.0 0.1 0.087 12.6 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3357) 7tm_1 PF00001.16 EFE44073.1 - 0.0047 16.1 0.9 0.0092 15.1 0.1 2.0 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF2207 PF09972.4 EFE44073.1 - 0.011 14.4 0.1 0.017 13.7 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) UPF0233 PF06781.7 EFE44073.1 - 0.066 12.8 0.4 0.27 10.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0233) Baculo_11_kDa PF06143.6 EFE44073.1 - 0.18 11.1 1.6 1.1 8.6 0.1 2.4 2 0 0 2 2 2 0 Baculovirus 11 kDa family RNA_polI_A34 PF08208.6 EFE44073.1 - 0.42 10.2 18.8 0.028 14.1 6.1 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1183 PF06682.7 EFE44073.1 - 0.45 10.0 2.9 1.4 8.4 2.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1183) Cytochrom_B_N PF00033.14 EFE44073.1 - 0.89 8.8 3.8 4.3 6.6 2.6 2.1 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Ctr PF04145.10 EFE44073.1 - 4.8 7.2 5.1 3.7 7.6 1.2 2.3 1 1 1 2 2 2 0 Ctr copper transporter family GRP PF07172.6 EFE44073.1 - 7.6 7.0 10.9 31 5.1 0.1 3.9 2 1 1 3 3 3 0 Glycine rich protein family TPR_11 PF13414.1 EFE44075.1 - 3.7e-07 29.6 5.2 0.0015 18.1 0.2 4.8 4 1 0 4 4 4 2 TPR repeat TPR_1 PF00515.23 EFE44075.1 - 0.0038 16.7 0.4 0.43 10.2 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFE44075.1 - 0.0044 16.9 3.1 4.7 7.2 0.0 4.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFE44075.1 - 0.006 16.6 3.2 2.1 8.7 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE44075.1 - 0.013 15.3 1.4 0.57 10.2 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFE44075.1 - 0.1 13.2 10.5 7.2 7.5 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat BAF1_ABF1 PF04684.8 EFE44075.1 - 0.22 10.3 10.0 0.052 12.3 4.7 1.5 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor TPR_19 PF14559.1 EFE44075.1 - 0.35 11.2 5.4 26 5.2 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFE44075.1 - 0.4 11.4 13.7 1.2 9.9 0.0 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 EFE44075.1 - 10 6.2 7.2 30 4.7 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Nnf1 PF03980.9 EFE44076.1 - 1.2e-31 108.9 3.6 1.2e-31 108.9 2.5 1.9 2 0 0 2 2 2 1 Nnf1 DUF1887 PF09002.6 EFE44076.1 - 0.0045 15.4 1.0 0.0059 15.0 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1887) NYD-SP28 PF14772.1 EFE44076.1 - 0.0083 16.2 4.1 0.0083 16.2 2.8 2.0 2 0 0 2 2 2 1 Sperm tail Nup54 PF13874.1 EFE44076.1 - 0.0092 15.6 4.9 0.012 15.2 2.4 1.9 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Apolipoprotein PF01442.13 EFE44076.1 - 0.01 15.3 6.3 0.01 15.3 4.3 1.9 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain FliD_C PF07195.7 EFE44076.1 - 0.013 14.8 0.2 0.018 14.3 0.1 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF948 PF06103.6 EFE44076.1 - 0.021 14.6 0.5 0.059 13.2 0.3 1.7 2 0 0 2 2 1 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.7 EFE44076.1 - 0.051 13.3 0.7 0.11 12.2 0.5 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lectin_N PF03954.9 EFE44076.1 - 0.059 12.7 0.9 0.14 11.5 0.4 1.8 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain bZIP_1 PF00170.16 EFE44076.1 - 0.07 13.0 9.0 0.32 10.9 2.7 2.6 2 0 0 2 2 2 0 bZIP transcription factor Ded_cyto PF06920.8 EFE44076.1 - 0.077 12.2 1.2 0.1 11.9 0.3 1.6 2 0 0 2 2 2 0 Dedicator of cytokinesis FlgN PF05130.7 EFE44076.1 - 0.08 13.1 11.0 0.096 12.9 6.9 1.8 1 1 1 2 2 2 0 FlgN protein Mod_r PF07200.8 EFE44076.1 - 0.098 12.5 6.3 0.078 12.9 3.2 1.7 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Kri1 PF05178.7 EFE44076.1 - 0.13 12.5 3.3 1.4 9.2 2.4 2.1 2 0 0 2 2 2 0 KRI1-like family DUF4515 PF14988.1 EFE44076.1 - 0.15 11.6 7.2 0.18 11.4 4.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) Syntaxin-6_N PF09177.6 EFE44076.1 - 0.27 11.6 3.6 0.53 10.7 1.6 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal LUC7 PF03194.10 EFE44076.1 - 0.48 9.9 8.4 0.82 9.1 5.8 1.6 1 1 0 1 1 1 0 LUC7 N_terminus TMPIT PF07851.8 EFE44076.1 - 0.61 9.1 2.5 0.77 8.7 1.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein Syntaxin PF00804.20 EFE44076.1 - 0.75 9.9 7.9 0.97 9.6 4.7 1.9 1 1 1 2 2 2 0 Syntaxin FlaC_arch PF05377.6 EFE44076.1 - 0.77 9.7 5.9 0.92 9.4 1.1 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Microtub_assoc PF07989.6 EFE44076.1 - 0.8 9.5 5.8 0.24 11.2 1.1 2.1 2 0 0 2 2 2 0 Microtubule associated Snapin_Pallidin PF14712.1 EFE44076.1 - 2.2 8.6 7.0 1 9.7 2.8 2.0 2 1 0 2 2 1 0 Snapin/Pallidin Prefoldin_2 PF01920.15 EFE44076.1 - 3.1 7.5 10.8 0.55 10.0 3.4 2.4 2 1 0 3 3 2 0 Prefoldin subunit Pkinase PF00069.20 EFE44077.1 - 8.2e-72 241.4 0.0 1.3e-71 240.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44077.1 - 4.5e-33 114.4 0.0 8.3e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44077.1 - 0.00048 19.1 0.1 0.003 16.5 0.0 2.2 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 EFE44077.1 - 0.022 14.5 2.8 0.049 13.3 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Disulph_isomer PF06491.6 EFE44077.1 - 0.12 12.2 0.1 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Disulphide isomerase Choline_kinase PF01633.15 EFE44077.1 - 0.15 11.6 0.1 0.15 11.6 0.1 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase SelP_N PF04592.9 EFE44077.1 - 0.21 10.9 7.4 0.34 10.2 5.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region BAF1_ABF1 PF04684.8 EFE44077.1 - 0.57 8.9 23.1 0.89 8.3 16.0 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SIR2 PF02146.12 EFE44078.1 - 2.5e-34 118.5 0.0 3.7e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Sir2 family AATase PF07247.7 EFE44079.1 - 3.1e-22 78.7 0.0 6e-22 77.8 0.0 1.5 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 EFE44079.1 - 5.2e-05 22.2 0.0 0.00017 20.5 0.0 1.7 2 0 0 2 2 2 1 Condensation domain Cation_efflux PF01545.16 EFE44080.1 - 2.9e-58 197.2 0.4 3.6e-58 196.8 0.3 1.1 1 0 0 1 1 1 1 Cation efflux family TrkH PF02386.11 EFE44080.1 - 0.029 12.9 0.2 0.047 12.2 0.1 1.2 1 0 0 1 1 1 0 Cation transport protein FGGY_C PF02782.11 EFE44081.1 - 3e-30 105.3 0.0 7.6e-30 104.0 0.0 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFE44081.1 - 1.6e-10 40.7 0.0 0.00012 21.4 0.0 3.6 2 2 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Xpo1 PF08389.7 EFE44082.1 - 9.9e-38 129.3 0.8 9.9e-38 129.3 0.6 2.7 3 0 0 3 3 3 1 Exportin 1-like protein SEO_N PF14576.1 EFE44082.1 - 0.017 14.3 0.1 0.054 12.7 0.1 1.8 1 0 0 1 1 1 0 Sieve element occlusion N-terminus Esterase PF00756.15 EFE44083.1 - 2.7e-53 180.9 0.0 3.3e-53 180.6 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 EFE44083.1 - 2.9e-06 27.0 0.0 3.9e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFE44083.1 - 3.8e-05 23.0 0.1 6e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFE44083.1 - 0.00011 22.1 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 EFE44083.1 - 0.00015 20.7 0.0 0.00024 20.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Esterase_phd PF10503.4 EFE44083.1 - 0.0016 17.7 0.0 0.057 12.6 0.0 2.0 2 0 0 2 2 2 1 Esterase PHB depolymerase PGAP1 PF07819.8 EFE44083.1 - 0.0037 16.8 0.0 0.0047 16.5 0.0 1.1 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 EFE44083.1 - 0.0049 16.4 0.0 0.0071 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.15 EFE44083.1 - 0.0072 15.9 0.0 0.022 14.2 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 EFE44083.1 - 0.019 14.4 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.8 EFE44083.1 - 0.055 13.0 0.0 0.16 11.5 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase PF07224.6 EFE44083.1 - 0.078 11.7 0.0 0.26 10.0 0.0 1.7 2 0 0 2 2 2 0 Chlorophyllase Peptidase_C50 PF03568.12 EFE44084.1 - 1.2e-113 379.6 0.0 2.8e-113 378.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.2 EFE44084.1 - 0.00021 20.5 0.0 0.005 16.0 0.0 2.4 1 1 0 1 1 1 1 CHAT domain TPR_2 PF07719.12 EFE44084.1 - 0.039 13.8 1.3 16 5.6 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Muted PF14942.1 EFE44085.1 - 0.02 14.7 1.8 0.027 14.3 1.2 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Syntaxin PF00804.20 EFE44085.1 - 0.029 14.5 2.2 0.044 13.9 1.5 1.2 1 0 0 1 1 1 0 Syntaxin YtpI PF14007.1 EFE44089.1 - 0.036 13.9 1.3 0.097 12.6 0.9 1.6 1 0 0 1 1 1 0 YtpI-like protein DUF2059 PF09832.4 EFE44090.1 - 0.054 13.5 0.0 0.62 10.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2059) Fungal_trans PF04082.13 EFE44091.1 - 4.5e-21 74.8 0.3 9.1e-21 73.8 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE44091.1 - 7.2e-10 38.6 12.2 1.6e-09 37.4 8.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 EFE44091.1 - 0.59 10.3 7.7 1.2 9.3 5.3 1.5 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region MFS_1 PF07690.11 EFE44092.1 - 4.3e-20 71.7 35.6 2.9e-11 42.6 4.4 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily ATG22 PF11700.3 EFE44092.1 - 3.3e-09 35.7 6.0 6.6e-07 28.1 0.2 2.6 2 1 0 3 3 3 2 Vacuole effluxer Atg22 like MFS_2 PF13347.1 EFE44092.1 - 5.3e-06 25.0 13.8 0.0031 15.9 3.7 3.1 2 1 0 2 2 2 2 MFS/sugar transport protein LacY_symp PF01306.14 EFE44092.1 - 0.0036 15.8 11.3 0.019 13.5 1.2 3.1 3 0 0 3 3 3 2 LacY proton/sugar symporter MFS_1_like PF12832.2 EFE44092.1 - 0.008 15.9 5.4 2.2 8.1 0.0 3.6 4 0 0 4 4 4 2 MFS_1 like family zf-rbx1 PF12678.2 EFE44093.1 - 3.6e-12 46.2 0.6 6.6e-12 45.3 0.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 EFE44093.1 - 2.5e-09 36.7 7.7 2.3e-08 33.7 5.4 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFE44093.1 - 1.8e-07 30.6 0.2 3.9e-07 29.6 0.1 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE44093.1 - 1.8e-07 30.6 3.9 2.1e-06 27.2 1.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFE44093.1 - 1.8e-05 24.6 1.7 1.8e-05 24.6 1.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE44093.1 - 0.0003 20.4 3.9 0.0022 17.6 3.0 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 EFE44093.1 - 0.0033 17.2 5.2 0.056 13.2 3.6 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF329 PF03884.9 EFE44093.1 - 0.0072 15.8 0.4 0.021 14.3 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF329) zf-RING_UBOX PF13445.1 EFE44093.1 - 0.25 11.0 5.7 0.94 9.2 3.9 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 EFE44093.1 - 1.6 8.3 4.5 0.47 10.0 1.0 1.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain CENP-B_dimeris PF09026.5 EFE44093.1 - 9.6 6.5 18.9 1.1e+02 3.0 0.0 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SurE PF01975.12 EFE44094.1 - 4e-36 124.1 0.5 5.1e-36 123.8 0.4 1.1 1 0 0 1 1 1 1 Survival protein SurE DUF3431 PF11913.3 EFE44095.1 - 9.7e-78 260.6 0.0 1.3e-77 260.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DnaJ PF00226.26 EFE44097.1 - 1e-18 66.8 1.3 1e-18 66.8 0.9 2.2 2 0 0 2 2 2 1 DnaJ domain Trypan_PARP PF05887.6 EFE44097.1 - 0.0024 17.7 15.4 0.0024 17.7 10.7 2.7 2 1 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) zf-B_box PF00643.19 EFE44097.1 - 0.0078 16.0 2.4 0.017 15.0 1.7 1.5 1 0 0 1 1 1 1 B-box zinc finger zf-RING_5 PF14634.1 EFE44097.1 - 0.57 9.9 3.6 1.1 9.0 2.5 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Neisseria_TspB PF05616.8 EFE44097.1 - 0.61 8.3 20.5 1.1 7.5 14.2 1.4 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein tRNA-synt_1 PF00133.17 EFE44098.1 - 3e-216 719.0 0.2 1.2e-215 717.1 0.2 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EFE44098.1 - 2.5e-34 118.2 0.4 2.5e-34 118.2 0.3 2.3 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EFE44098.1 - 3.2e-17 62.2 0.7 4.7e-08 32.0 0.0 4.8 3 2 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 EFE44098.1 - 6.4e-09 35.3 3.4 9.3e-06 25.0 0.0 2.9 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.14 EFE44098.1 - 0.0063 15.6 0.0 0.28 10.2 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Herpes_UL56 PF04534.7 EFE44098.1 - 0.059 13.0 3.3 3.4 7.3 0.0 2.9 3 0 0 3 3 3 0 Herpesvirus UL56 protein Pkinase PF00069.20 EFE44099.1 - 3.5e-22 78.8 0.0 4.9e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44099.1 - 2.3e-06 26.8 0.2 0.00038 19.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 EFE44100.1 - 3.9e-08 32.7 0.0 1.1e-07 31.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44100.1 - 7.7e-05 21.8 0.0 0.00011 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 EFE44101.1 - 6e-59 199.3 0.0 7e-59 199.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44101.1 - 3.4e-20 72.1 0.0 4.7e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFE44101.1 - 6.4e-09 35.8 0.1 0.00015 21.5 0.1 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE44101.1 - 0.01 15.3 0.0 0.025 14.1 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.17 EFE44101.1 - 0.015 14.6 0.2 0.026 13.8 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 EFE44101.1 - 0.052 12.6 0.0 0.092 11.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE44101.1 - 0.063 12.2 0.0 0.13 11.1 0.0 1.5 2 0 0 2 2 2 0 Kinase-like Methyltransf_2 PF00891.13 EFE44102.1 - 3.2e-41 141.1 0.0 4.5e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 EFE44102.1 - 0.00023 21.7 0.1 0.00096 19.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE44102.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AMP-binding PF00501.23 EFE44103.1 - 3.6e-52 177.1 0.0 5.1e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Thioesterase PF00975.15 EFE44103.1 - 8.6e-27 94.8 0.0 6.2e-26 92.0 0.0 2.4 2 1 0 2 2 2 1 Thioesterase domain PP-binding PF00550.20 EFE44103.1 - 3.5e-09 36.7 0.0 8.1e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.2 EFE44103.1 - 9.8e-06 25.6 0.1 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE44103.1 - 0.001 18.8 0.0 0.0026 17.5 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Methyltransf_2 PF00891.13 EFE44104.1 - 3.7e-28 98.3 0.0 6.7e-28 97.4 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 EFE44104.1 - 0.0024 17.5 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GD_AH_C PF04295.8 EFE44104.1 - 0.13 10.9 0.0 0.27 9.8 0.0 1.5 1 1 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus p450 PF00067.17 EFE44105.1 - 5.3e-52 176.8 0.0 2.2e-49 168.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 MFS_1 PF07690.11 EFE44107.1 - 5.9e-10 38.3 61.3 5.5e-08 31.9 9.0 4.4 2 2 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE44107.1 - 6.7e-06 24.9 7.8 6.7e-06 24.9 5.4 3.0 4 1 0 4 4 4 1 Sugar (and other) transporter NmrA PF05368.8 EFE44108.1 - 1.5e-28 99.6 0.0 4e-28 98.2 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFE44108.1 - 1.7e-16 60.7 0.0 2.4e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EFE44108.1 - 0.074 12.9 0.2 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 short chain dehydrogenase p450 PF00067.17 EFE44109.1 - 1.4e-10 40.3 0.0 2.5e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 RNase_P_p30 PF01876.11 EFE44110.1 - 1.3e-19 69.9 0.2 2.1e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 RNase P subunit p30 F-box-like PF12937.2 EFE44111.1 - 5.7e-05 22.7 0.0 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE44111.1 - 0.0002 20.9 0.0 0.00044 19.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain DUF3725 PF12523.3 EFE44111.1 - 0.28 11.3 0.0 0.55 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) Abhydrolase_6 PF12697.2 EFE44112.1 - 3.1e-25 89.3 0.0 3.9e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE44112.1 - 4.5e-10 39.4 0.0 9.2e-10 38.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFE44112.1 - 0.0072 15.9 0.6 0.018 14.6 0.2 1.7 2 1 0 2 2 2 1 PGAP1-like protein Abhydrolase_1 PF00561.15 EFE44112.1 - 0.009 15.5 0.0 0.51 9.8 0.0 2.7 2 1 1 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFE44112.1 - 0.021 14.0 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_8 PF06259.7 EFE44112.1 - 0.068 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase DUF2419 PF10343.4 EFE44112.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2419) PE-PPE PF08237.6 EFE44112.1 - 0.19 11.1 0.2 0.55 9.6 0.0 1.7 2 0 0 2 2 2 0 PE-PPE domain A_deaminase PF00962.17 EFE44114.1 - 1.6e-112 375.6 0.0 2.1e-112 375.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF676 PF05057.9 EFE44114.1 - 0.047 12.9 0.7 1.5 8.0 0.0 2.4 1 1 0 2 2 2 0 Putative serine esterase (DUF676) UCH PF00443.24 EFE44116.1 - 6.2e-29 100.9 0.1 8.5e-29 100.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE44116.1 - 1.5e-19 70.5 0.2 2.6e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.1 EFE44116.1 - 9.4e-05 21.8 0.4 0.0075 15.5 0.3 2.3 1 1 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase CpXC PF14353.1 EFE44116.1 - 0.01 15.7 1.4 0.26 11.2 0.0 2.3 2 0 0 2 2 2 0 CpXC protein IL22 PF14565.1 EFE44116.1 - 0.15 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor MitMem_reg PF13012.1 EFE44118.1 - 2.1e-39 134.1 0.2 4e-39 133.2 0.1 1.5 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.16 EFE44118.1 - 8.2e-28 96.4 0.1 2.1e-27 95.1 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ADK PF00406.17 EFE44119.1 - 1.5e-46 157.9 0.8 9.3e-46 155.4 0.1 2.0 2 0 0 2 2 2 1 Adenylate kinase ADK_lid PF05191.9 EFE44119.1 - 2.3e-14 52.7 0.0 5.8e-14 51.4 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.1 EFE44119.1 - 0.057 13.2 0.1 0.18 11.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain Mucin PF01456.12 EFE44120.1 - 0.17 11.6 5.7 0.18 11.5 3.9 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein CTD_bind PF04818.8 EFE44121.1 - 0.00058 20.0 0.0 0.0021 18.2 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. VHS PF00790.14 EFE44121.1 - 0.0019 17.8 0.0 0.0066 16.0 0.0 1.8 2 0 0 2 2 2 1 VHS domain MULE PF10551.4 EFE44121.1 - 0.14 12.3 0.0 13 5.9 0.0 2.3 2 0 0 2 2 2 0 MULE transposase domain HOOK PF05622.7 EFE44122.1 - 3.8e-17 61.3 49.9 3.8e-17 61.3 34.6 2.8 1 1 1 2 2 2 1 HOOK protein Casc1 PF12366.3 EFE44123.1 - 0.0092 15.5 0.7 0.0098 15.4 0.5 1.2 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 USP8_interact PF08941.5 EFE44123.1 - 0.072 12.4 0.3 0.081 12.2 0.2 1.2 1 0 0 1 1 1 0 USP8 interacting Coprogen_oxidas PF01218.13 EFE44124.1 - 3.8e-120 399.9 0.0 8.3e-120 398.8 0.0 1.6 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase Atg8 PF02991.11 EFE44125.1 - 1.1e-50 169.9 0.2 1.9e-50 169.1 0.2 1.4 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 EFE44125.1 - 8.5e-06 25.8 0.0 1.6e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Mito_carr PF00153.22 EFE44127.1 - 2.2e-23 81.7 2.6 9.5e-15 54.0 0.0 3.4 3 1 0 3 3 3 2 Mitochondrial carrier protein Apc15p PF05841.6 EFE44128.1 - 8.4e-23 81.4 0.2 8.4e-23 81.4 0.1 2.9 3 1 0 3 3 3 1 Apc15p protein CHZ PF09649.5 EFE44129.1 - 3.5e-13 48.5 0.3 3.5e-13 48.5 0.2 2.1 2 0 0 2 2 2 1 Histone chaperone domain CHZ HSP70 PF00012.15 EFE44130.1 - 3.3e-271 900.5 6.6 3.8e-271 900.2 4.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFE44130.1 - 3.6e-16 58.6 0.0 1.3e-15 56.8 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 EFE44130.1 - 0.0017 17.5 0.1 0.023 13.7 0.0 2.2 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase FGGY_C PF02782.11 EFE44130.1 - 0.0029 17.2 0.0 0.0079 15.8 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 EFE44130.1 - 0.02 14.6 2.1 3.4 7.5 0.1 3.5 2 2 0 2 2 2 0 Cell division protein FtsA Fungal_trans PF04082.13 EFE44131.1 - 8e-23 80.6 0.5 1.2e-22 80.0 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain PAX PF00292.13 EFE44131.1 - 0.0092 15.6 0.4 0.074 12.7 0.6 2.0 2 0 0 2 2 2 1 'Paired box' domain Zn_clus PF00172.13 EFE44131.1 - 0.011 15.6 13.4 0.02 14.7 9.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DIOX_N PF14226.1 EFE44132.1 - 3.7e-30 104.8 0.1 9e-30 103.5 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFE44132.1 - 3.4e-17 62.5 0.0 5.7e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Nop14 PF04147.7 EFE44133.1 - 0.03 12.2 3.8 0.033 12.1 2.7 1.0 1 0 0 1 1 1 0 Nop14-like family Tim54 PF11711.3 EFE44133.1 - 0.08 11.5 1.5 0.087 11.3 1.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Daxx PF03344.10 EFE44133.1 - 0.1 11.0 5.1 0.1 11.0 3.5 1.0 1 0 0 1 1 1 0 Daxx Family Sporozoite_P67 PF05642.6 EFE44133.1 - 0.11 10.2 0.9 0.12 10.2 0.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PI3K_1B_p101 PF10486.4 EFE44133.1 - 0.15 9.6 1.3 0.15 9.6 0.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit BSP_II PF05432.6 EFE44133.1 - 0.34 10.1 11.1 0.39 9.9 7.7 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Pox_RNA_Pol_19 PF05320.7 EFE44133.1 - 0.63 9.7 4.6 0.71 9.6 3.2 1.1 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit YqfQ PF14181.1 EFE44133.1 - 2.9 7.9 5.2 3.2 7.7 3.6 1.1 1 0 0 1 1 1 0 YqfQ-like protein Myc_N PF01056.13 EFE44133.1 - 3.5 6.6 7.0 3.7 6.6 4.9 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Glu_synthase PF01645.12 EFE44134.1 - 8.6e-158 525.0 0.1 2.8e-157 523.3 0.0 1.8 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.16 EFE44134.1 - 4e-138 460.0 0.0 5.8e-138 459.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 EFE44134.1 - 3.1e-119 397.5 0.0 5e-119 396.8 0.0 1.3 1 0 0 1 1 1 1 Glutamate synthase central domain GXGXG PF01493.14 EFE44134.1 - 1.8e-65 219.7 2.7 3.5e-65 218.7 1.9 1.5 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 EFE44134.1 - 1.8e-22 79.0 0.0 4.9e-22 77.6 0.0 1.7 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 EFE44134.1 - 5.5e-17 62.3 0.0 1.6e-16 60.8 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFE44134.1 - 1.1e-10 41.9 0.8 0.00027 21.0 0.1 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFE44134.1 - 2.6e-09 36.9 0.1 1e-08 35.0 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFE44134.1 - 5.8e-08 33.0 0.0 3.6e-05 24.0 0.0 3.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 EFE44134.1 - 6e-07 28.8 0.7 9.6e-07 28.2 0.1 1.6 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.19 EFE44134.1 - 6.2e-06 25.3 1.0 6.6e-05 21.9 0.3 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFE44134.1 - 4.2e-05 22.5 1.1 0.00033 19.6 0.3 2.4 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 EFE44134.1 - 4.6e-05 22.0 0.2 4.6e-05 22.0 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.2 EFE44134.1 - 6.1e-05 22.2 0.3 0.00013 21.2 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFE44134.1 - 0.00052 19.1 0.0 0.001 18.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain DJ-1_PfpI PF01965.19 EFE44134.1 - 0.0033 16.8 0.0 0.017 14.5 0.0 2.1 2 0 0 2 2 2 1 DJ-1/PfpI family AlaDh_PNT_C PF01262.16 EFE44134.1 - 0.0045 16.5 0.2 0.02 14.4 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 EFE44134.1 - 0.0062 15.6 0.2 0.0062 15.6 0.1 2.2 3 0 0 3 3 3 1 Thi4 family NAD_binding_7 PF13241.1 EFE44134.1 - 0.013 15.7 2.1 0.85 9.9 0.1 2.9 3 0 0 3 3 2 0 Putative NAD(P)-binding GIDA PF01134.17 EFE44134.1 - 0.027 13.3 2.8 0.036 12.9 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_Gly3P_dh_N PF01210.18 EFE44134.1 - 0.039 13.6 0.1 0.12 12.1 0.0 1.8 2 0 0 2 2 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_9 PF13454.1 EFE44134.1 - 0.059 13.1 0.0 0.23 11.2 0.0 2.1 1 0 0 1 1 1 0 FAD-NAD(P)-binding FMO-like PF00743.14 EFE44134.1 - 0.07 11.3 0.1 0.64 8.1 0.0 2.2 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like MADF_DNA_bdg PF10545.4 EFE44134.1 - 0.2 11.8 0.6 0.54 10.4 0.4 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF3128 PF11326.3 EFE44135.1 - 1.9e-30 104.8 3.3 3.7e-30 103.8 2.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) DUF605 PF04652.11 EFE44135.1 - 0.015 14.7 5.9 0.016 14.6 4.1 1.1 1 0 0 1 1 1 0 Vta1 like RNA12 PF10443.4 EFE44136.1 - 3.7e-154 513.3 0.4 5.2e-154 512.8 0.3 1.2 1 0 0 1 1 1 1 RNA12 protein Arch_ATPase PF01637.13 EFE44136.1 - 0.00094 18.9 0.1 0.0067 16.1 0.0 2.1 1 1 0 1 1 1 1 Archaeal ATPase DUF2487 PF10673.4 EFE44136.1 - 0.0015 18.3 0.0 0.0037 17.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2487) RRM_1 PF00076.17 EFE44136.1 - 0.0057 16.2 0.0 0.014 15.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE44136.1 - 0.0076 16.0 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAT1 PF09770.4 EFE44137.1 - 2.5 6.2 26.8 3.3 5.8 18.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RNR_inhib PF08591.5 EFE44137.1 - 6.1 7.8 8.4 14 6.6 0.5 2.9 2 1 0 2 2 2 0 Ribonucleotide reductase inhibitor p450 PF00067.17 EFE44138.1 - 0.00063 18.3 0.0 0.0011 17.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.27 EFE44139.1 - 5e-21 73.7 1.3 9.8e-10 37.9 0.0 6.9 6 1 1 7 7 7 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 EFE44139.1 - 4.8e-07 28.9 0.1 1.4e-06 27.3 0.0 1.6 1 1 1 2 2 2 1 Coatomer WD associated region eIF2A PF08662.6 EFE44139.1 - 1.6e-06 27.9 0.3 1.2e-05 25.1 0.0 2.4 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A DUF3312 PF11768.3 EFE44139.1 - 0.00016 20.0 0.0 0.06 11.5 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3312) IKI3 PF04762.7 EFE44139.1 - 0.0048 14.7 0.6 0.017 13.0 0.3 1.7 1 1 1 2 2 2 2 IKI3 family Apc4_WD40 PF12894.2 EFE44139.1 - 0.076 12.5 0.0 2.3 7.8 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DNA_pol_alpha_N PF12254.3 EFE44139.1 - 0.62 9.9 8.7 0.091 12.5 3.0 1.9 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal MFS_1 PF07690.11 EFE44141.1 - 8.3e-36 123.4 18.4 8.3e-36 123.4 12.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE44141.1 - 2.4e-06 26.4 8.5 2.4e-06 26.4 5.9 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter Sulfate_tra_GLY PF13792.1 EFE44141.1 - 0.012 15.2 2.8 0.012 15.2 1.9 3.3 3 1 0 3 3 3 0 Sulfate transporter N-terminal domain with GLY motif LacY_symp PF01306.14 EFE44141.1 - 0.024 13.2 0.1 0.047 12.2 0.1 1.5 1 0 0 1 1 1 0 LacY proton/sugar symporter COX14 PF14880.1 EFE44141.1 - 0.16 11.5 0.1 0.62 9.7 0.1 1.9 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF4298 PF14131.1 EFE44142.1 - 0.025 14.4 2.0 0.055 13.3 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) DUF2202 PF09968.4 EFE44142.1 - 0.064 12.9 3.1 2.2 7.9 1.9 2.3 2 0 0 2 2 2 0 Uncharacterized protein domain (DUF2202) DUF2347 PF09804.4 EFE44142.1 - 0.099 11.9 3.3 0.17 11.1 2.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) RapA_C PF12137.3 EFE44142.1 - 0.45 9.3 11.0 0.72 8.6 7.6 1.2 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal MerR-DNA-bind PF09278.6 EFE44142.1 - 1.9 8.9 5.6 2.2 8.7 2.1 2.4 1 1 1 2 2 2 0 MerR, DNA binding VTC PF09359.5 EFE44143.1 - 4.8e-83 278.4 0.0 8.3e-83 277.6 0.0 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.14 EFE44143.1 - 8.7e-22 78.1 7.2 1.3e-15 57.9 1.0 3.2 2 1 1 3 3 3 2 SPX domain DUF202 PF02656.10 EFE44143.1 - 4.5e-10 39.6 1.8 4.5e-10 39.6 1.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) RAP1 PF07218.6 EFE44143.1 - 0.096 10.7 0.1 0.15 10.0 0.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) 6PF2K PF01591.13 EFE44144.1 - 5.7e-68 228.3 0.0 5.7e-46 156.3 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EFE44144.1 - 5.7e-25 88.2 0.0 1.3e-24 87.1 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EFE44144.1 - 3.9e-05 23.5 0.0 0.067 13.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EFE44144.1 - 0.0017 19.1 0.0 0.0067 17.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain DUF202 PF02656.10 EFE44145.1 - 0.00025 21.1 3.5 0.0042 17.2 2.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF202) DUF998 PF06197.8 EFE44145.1 - 0.017 14.4 2.3 0.16 11.2 1.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF998) DUF3169 PF11368.3 EFE44145.1 - 0.027 13.6 0.2 0.031 13.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) F-box PF00646.28 EFE44146.1 - 4.8e-06 26.0 0.0 9.7e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE44146.1 - 0.0005 19.7 0.2 0.0013 18.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like RNase_H2-Ydr279 PF09468.5 EFE44146.1 - 0.018 14.2 0.1 0.026 13.7 0.1 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) HemY_N PF07219.8 EFE44146.1 - 0.079 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 HemY protein N-terminus FMN_dh PF01070.13 EFE44147.1 - 3.6e-101 338.5 0.0 4.9e-101 338.1 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EFE44147.1 - 2.9e-17 62.2 0.0 3.6e-08 33.0 0.0 3.0 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.20 EFE44147.1 - 7.3e-07 28.4 0.3 0.0011 17.9 0.1 2.3 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 EFE44147.1 - 4.5e-06 25.8 0.0 7e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 EFE44147.1 - 0.0033 16.6 1.3 0.014 14.5 0.0 2.2 2 1 0 2 2 2 1 Nitronate monooxygenase ATP11 PF06644.6 EFE44147.1 - 0.0057 16.1 0.0 0.0091 15.5 0.0 1.2 1 0 0 1 1 1 1 ATP11 protein His_biosynth PF00977.16 EFE44147.1 - 0.026 13.8 0.0 0.05 12.8 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Cauli_VI PF01693.11 EFE44148.1 - 6.3e-34 115.7 4.8 2.4e-16 59.4 0.2 2.5 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.19 EFE44148.1 - 5.1e-28 98.0 0.0 8.1e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 RNase H ETX_MTX2 PF03318.8 EFE44149.1 - 4.1 6.8 9.6 0.021 14.4 0.8 1.6 2 1 0 2 2 2 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 APH PF01636.18 EFE44150.1 - 2.6e-17 63.3 0.4 1.2e-16 61.1 0.0 2.3 2 2 1 3 3 3 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE44150.1 - 0.055 12.0 0.3 0.095 11.3 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) DUF4597 PF15366.1 EFE44150.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4597) FGGY_C PF02782.11 EFE44151.1 - 1.5e-71 240.1 0.6 3.4e-71 238.9 0.4 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFE44151.1 - 2.4e-53 180.9 0.0 3.9e-53 180.2 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain MIP PF00230.15 EFE44152.1 - 2.5e-54 184.1 0.8 3.2e-54 183.7 0.5 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF2644 PF10841.3 EFE44152.1 - 0.26 11.3 4.4 6.3 6.9 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2644) Peptidase_S8 PF00082.17 EFE44154.1 - 9.7e-41 139.7 0.9 1.6e-40 139.0 0.7 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE44154.1 - 2.4e-12 47.2 0.0 4.2e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 TBPIP_N PF15517.1 EFE44154.1 - 0.036 13.6 0.0 0.075 12.6 0.0 1.5 1 0 0 1 1 1 0 TBP-interacting protein N-terminus Peptidase_S10 PF00450.17 EFE44156.1 - 1.2e-84 284.9 0.0 1.6e-84 284.4 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 EFE44156.1 - 0.0053 16.6 0.0 0.016 15.0 0.0 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF3752 PF12572.3 EFE44157.1 - 2.3e-43 147.9 12.7 2.3e-43 147.9 8.8 2.6 3 1 0 3 3 3 1 Protein of unknown function (DUF3752) DUF1202 PF06717.6 EFE44158.1 - 0.068 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1202) CASP_C PF08172.7 EFE44158.1 - 0.085 11.8 1.3 0.12 11.3 0.9 1.2 1 0 0 1 1 1 0 CASP C terminal DrrA_P4M PF14860.1 EFE44158.1 - 0.087 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain tRNA-synt_2c PF01411.14 EFE44159.1 - 2.1e-181 604.0 1.3 5.8e-179 595.9 0.1 2.2 1 1 0 2 2 2 2 tRNA synthetases class II (A) tRNA_SAD PF07973.9 EFE44159.1 - 4.9e-18 64.7 0.6 1.4e-17 63.2 0.4 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 EFE44159.1 - 1.6e-08 34.1 0.6 4.6e-08 32.6 0.4 1.9 1 0 0 1 1 1 1 DHHA1 domain zf-RING_2 PF13639.1 EFE44161.1 - 1e-13 50.8 6.6 1.7e-13 50.1 4.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFE44161.1 - 2.7e-08 33.3 4.0 4.5e-08 32.6 2.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFE44161.1 - 1.2e-06 28.5 5.8 2.6e-06 27.4 4.0 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EFE44161.1 - 1.6e-06 27.7 3.8 2.6e-06 27.0 2.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFE44161.1 - 5.8e-06 26.2 5.8 9.6e-06 25.5 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFE44161.1 - 3e-05 23.6 2.6 5.1e-05 22.8 1.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFE44161.1 - 0.0021 17.8 3.2 0.0059 16.4 2.2 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 EFE44161.1 - 0.031 13.8 5.7 0.055 13.0 3.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 EFE44161.1 - 0.043 13.5 0.4 0.11 12.2 0.1 1.8 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EFE44161.1 - 0.045 13.6 5.0 0.096 12.5 3.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.24 EFE44161.1 - 0.072 12.7 5.7 0.14 11.8 3.9 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.3 EFE44161.1 - 0.46 10.4 3.9 1.6 8.7 2.7 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 EFE44161.1 - 0.71 9.9 5.7 1.4 8.9 3.9 1.5 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.1 EFE44161.1 - 2 8.2 7.3 0.7 9.6 1.8 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 DUF3844 PF12955.2 EFE44162.1 - 1.8e-39 133.9 4.7 3.5e-39 133.0 3.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Thioredoxin_4 PF13462.1 EFE44164.1 - 2e-07 31.1 0.0 3e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 EFE44164.1 - 0.27 10.7 2.0 1 8.8 0.1 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain CKS PF01111.14 EFE44165.1 - 1.2e-17 63.4 0.9 4e-17 61.7 0.1 2.0 2 1 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit Bromodomain PF00439.20 EFE44166.1 - 2e-18 66.0 1.6 4.2e-10 39.4 0.0 3.2 3 0 0 3 3 3 2 Bromodomain QRPTase_C PF01729.14 EFE44166.1 - 0.025 14.0 0.0 0.06 12.8 0.0 1.6 1 1 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Trypan_PARP PF05887.6 EFE44166.1 - 1.6 8.5 31.3 0.21 11.3 10.5 2.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) HSP70 PF00012.15 EFE44167.1 - 1.6e-232 772.7 8.3 1.8e-232 772.6 5.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFE44167.1 - 5.6e-16 58.0 0.6 3.8e-15 55.3 0.2 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EFE44167.1 - 0.00017 21.2 0.0 0.00032 20.3 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 EFE44167.1 - 0.017 14.0 0.6 0.21 10.4 0.2 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Activator_LAG-3 PF11498.3 EFE44167.1 - 0.17 10.6 0.0 0.49 9.0 0.0 1.6 2 0 0 2 2 2 0 Transcriptional activator LAG-3 RRF PF01765.14 EFE44168.1 - 4.7e-37 126.9 2.1 2.5e-36 124.6 1.5 1.9 1 1 0 1 1 1 1 Ribosome recycling factor Dehalogenase PF13486.1 EFE44169.1 - 0.049 13.0 0.1 0.061 12.7 0.1 1.5 1 1 0 1 1 1 0 Reductive dehalogenase subunit APC_CDC26 PF10471.4 EFE44170.1 - 5.2e-20 71.9 2.8 1.1e-19 70.9 1.9 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit 1 DUF3761 PF12587.3 EFE44170.1 - 0.11 12.6 0.3 0.14 12.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) Fungal_trans PF04082.13 EFE44171.1 - 2.1e-10 39.9 0.1 5.2e-10 38.6 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE44171.1 - 2.1e-05 24.3 7.9 3.7e-05 23.5 5.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF59 PF01883.14 EFE44172.1 - 4.8e-08 32.8 0.1 9.7e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF59 Shisa PF13908.1 EFE44172.1 - 0.13 12.4 0.3 0.47 10.6 0.0 1.9 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator FAM209 PF15206.1 EFE44172.1 - 0.14 11.9 0.5 0.36 10.6 0.0 1.9 2 0 0 2 2 2 0 FAM209 family DUF1294 PF06961.8 EFE44172.1 - 0.36 10.8 0.1 0.36 10.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1294) CAF-1_p150 PF11600.3 EFE44172.1 - 1.2 8.4 24.4 2.3 7.5 16.9 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF1777 PF08648.7 EFE44172.1 - 3 7.5 31.6 0.2 11.3 13.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) adh_short PF00106.20 EFE44174.1 - 8.2e-23 81.1 4.8 8.2e-23 81.1 3.3 2.3 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE44174.1 - 2.5e-21 76.5 0.0 3.9e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EFE44174.1 - 4e-06 26.4 0.2 9.9e-05 21.8 0.0 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 EFE44174.1 - 0.00015 20.9 0.1 0.00023 20.2 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase KR PF08659.5 EFE44174.1 - 0.00024 20.8 1.2 0.00024 20.8 0.8 2.0 2 1 0 2 2 2 1 KR domain TrkA_N PF02254.13 EFE44174.1 - 0.00038 20.4 0.0 0.00088 19.2 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_10 PF13460.1 EFE44174.1 - 0.015 15.2 1.1 0.051 13.5 0.1 2.3 2 1 1 3 3 3 0 NADH(P)-binding Polysacc_synt_2 PF02719.10 EFE44174.1 - 0.018 13.9 0.0 0.03 13.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.12 EFE44174.1 - 0.019 15.3 0.5 0.047 14.1 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.14 EFE44174.1 - 0.029 13.0 0.0 0.044 12.4 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 3HCDH_N PF02737.13 EFE44174.1 - 0.062 12.9 0.3 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Chromate_transp PF02417.10 EFE44175.1 - 1.9e-05 24.3 0.0 2.6e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Chromate transporter Chromate_transp PF02417.10 EFE44176.1 - 1.8e-32 112.2 26.0 7.5e-30 103.7 9.6 2.6 3 0 0 3 3 3 2 Chromate transporter GTP_EFTU PF00009.22 EFE44177.1 - 6.6e-43 146.3 0.0 1e-42 145.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EFE44177.1 - 4.9e-24 84.2 0.0 1.5e-23 82.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 EFE44177.1 - 2e-18 66.0 0.0 6.6e-18 64.3 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFE44177.1 - 1e-09 38.3 0.1 3.1e-09 36.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EFE44177.1 - 4.6e-07 29.5 0.0 1.2e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 EFE44177.1 - 5.4e-06 26.3 0.1 1.2e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE44177.1 - 0.00066 20.1 0.0 0.0019 18.6 0.0 1.9 1 1 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 EFE44177.1 - 0.1 11.8 0.2 1.3 8.2 0.1 2.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Ras PF00071.17 EFE44177.1 - 0.13 11.6 0.0 0.34 10.2 0.0 1.7 1 0 0 1 1 1 0 Ras family ketoacyl-synt PF00109.21 EFE44178.1 - 3.2e-65 220.1 0.4 1.6e-64 217.8 0.0 2.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFE44178.1 - 4.2e-65 220.1 0.0 7.5e-65 219.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 EFE44178.1 - 1.7e-59 200.5 0.0 5.4e-58 195.6 0.0 2.7 2 0 0 2 2 2 1 KR domain NAD_binding_4 PF07993.7 EFE44178.1 - 1e-57 194.9 0.0 2e-57 193.9 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein PS-DH PF14765.1 EFE44178.1 - 2.2e-57 194.4 0.0 3.4e-57 193.8 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 EFE44178.1 - 1.8e-44 151.5 0.0 2.5e-43 147.8 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFE44178.1 - 7.2e-31 106.5 0.5 1.7e-30 105.2 0.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Epimerase PF01370.16 EFE44178.1 - 5.5e-15 55.4 0.0 4.5e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.21 EFE44178.1 - 9.4e-11 41.3 0.0 3.1e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 EFE44178.1 - 2.1e-09 37.7 0.0 5.7e-09 36.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain 3Beta_HSD PF01073.14 EFE44178.1 - 8.8e-09 34.4 0.0 0.00017 20.3 0.0 2.7 3 0 0 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family ADH_N PF08240.7 EFE44178.1 - 3.1e-06 26.9 0.2 9.6e-06 25.3 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_18 PF12847.2 EFE44178.1 - 3.8e-05 24.2 0.0 0.00017 22.1 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.1 EFE44178.1 - 5.6e-05 24.0 0.1 0.27 12.1 0.0 3.1 2 1 1 3 3 2 2 Zinc-binding dehydrogenase Methyltransf_23 PF13489.1 EFE44178.1 - 0.0033 17.1 0.0 0.01 15.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 EFE44178.1 - 0.0076 16.4 0.1 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site PUA_2 PF14306.1 EFE44178.1 - 0.015 14.7 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 PUA-like domain Methyltransf_25 PF13649.1 EFE44178.1 - 0.019 15.2 0.0 0.22 11.9 0.0 2.7 2 0 0 2 2 2 0 Methyltransferase domain Semialdhyde_dh PF01118.19 EFE44178.1 - 0.15 12.4 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Thiolase_N PF00108.18 EFE44179.1 - 1.5e-97 325.7 0.0 2e-97 325.3 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFE44179.1 - 3.1e-44 149.3 1.8 6.2e-44 148.3 0.8 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EFE44179.1 - 2.3e-05 23.9 2.3 5.1e-05 22.8 1.0 2.0 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 EFE44179.1 - 0.13 11.9 1.8 2.5 7.8 0.0 3.0 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Zip PF02535.17 EFE44180.1 - 7.8e-41 140.0 7.1 9.9e-41 139.7 4.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2401 PF10287.4 EFE44181.1 - 2.2e-70 236.8 0.0 3e-70 236.3 0.0 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 EFE44181.1 - 4e-16 58.9 0.1 8.7e-16 57.8 0.0 1.6 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) AA_kinase PF00696.23 EFE44182.1 - 4.2e-31 108.3 0.7 5.6e-31 107.9 0.5 1.1 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 EFE44182.1 - 1.8e-11 43.5 0.0 3.9e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 PUA domain GPI-anchored PF10342.4 EFE44183.1 - 3.4e-07 30.6 1.4 1.6e-06 28.4 0.1 2.4 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family KRE9 PF05390.6 EFE44183.1 - 6.4e-07 29.6 7.1 1.3e-06 28.7 4.9 1.5 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 SRPRB PF09439.5 EFE44184.1 - 1.3e-26 92.9 0.1 3.4e-25 88.2 0.1 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 EFE44184.1 - 1.8e-07 30.5 0.0 0.00072 18.8 0.0 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFE44184.1 - 8.4e-05 22.5 0.0 0.00013 21.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFE44184.1 - 0.0015 19.0 0.1 0.016 15.7 0.1 2.5 1 1 0 1 1 1 1 Miro-like protein SRP54 PF00448.17 EFE44184.1 - 0.025 14.0 0.6 0.23 10.8 0.4 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.4 EFE44184.1 - 0.026 14.0 0.0 0.058 12.8 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 EFE44184.1 - 0.035 14.2 0.1 0.068 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EFE44184.1 - 0.039 13.4 0.4 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.1 EFE44184.1 - 0.059 13.3 0.4 0.098 12.6 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 EFE44184.1 - 0.059 13.0 0.0 0.16 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Gtr1_RagA PF04670.7 EFE44184.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region NACHT PF05729.7 EFE44184.1 - 0.072 12.7 0.0 0.52 9.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.12 EFE44184.1 - 0.082 12.4 0.0 6.9 6.1 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.1 EFE44184.1 - 0.098 12.2 0.2 0.47 9.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFE44184.1 - 0.15 12.3 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain PALP PF00291.20 EFE44185.1 - 6.5e-50 170.0 0.0 8.5e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 EFE44185.1 - 7.7e-07 28.8 0.0 1.2e-05 24.9 0.0 2.6 2 0 0 2 2 2 1 CBS domain Peptidase_M76 PF09768.4 EFE44186.1 - 9.4e-63 210.7 0.7 9.4e-63 210.7 0.5 1.6 2 0 0 2 2 2 1 Peptidase M76 family SprT-like PF10263.4 EFE44186.1 - 0.0021 17.7 0.6 0.0021 17.7 0.4 1.8 2 1 0 2 2 2 1 SprT-like family Tox-MPTase2 PF15638.1 EFE44186.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Pkinase PF00069.20 EFE44187.1 - 3.3e-69 232.9 0.0 4.1e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44187.1 - 9e-43 146.2 0.0 1.2e-42 145.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44187.1 - 1.9e-07 30.3 0.0 1.1e-06 27.8 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EFE44187.1 - 9.1e-05 21.6 0.1 0.00014 20.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 EFE44187.1 - 0.015 14.6 0.0 0.027 13.8 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 EFE44187.1 - 0.054 13.2 0.0 0.13 12.0 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family TIP41 PF04176.8 EFE44188.1 - 2e-73 245.5 0.0 4.5e-73 244.3 0.0 1.5 1 1 0 1 1 1 1 TIP41-like family Peptidase_M24 PF00557.19 EFE44190.1 - 7.5e-56 188.9 0.0 1e-55 188.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EFE44190.1 - 3.7e-23 81.4 0.0 7.8e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Trypan_PARP PF05887.6 EFE44192.1 - 0.046 13.5 6.3 0.045 13.5 4.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3530 PF12048.3 EFE44192.1 - 0.63 8.9 5.4 0.73 8.7 3.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) adh_short PF00106.20 EFE44193.1 - 3.1e-14 53.2 0.0 6.2e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE44193.1 - 1.6e-07 31.1 0.0 2.8e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 KR domain p450 PF00067.17 EFE44194.1 - 1.5e-63 214.9 0.0 1.6e-63 214.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_4 PF07993.7 EFE44195.1 - 2.5e-32 111.7 0.0 4.6e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.23 EFE44195.1 - 2.4e-25 88.8 0.0 7.5e-24 83.8 0.0 2.2 1 1 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.16 EFE44195.1 - 1.1e-13 51.1 0.0 1.7e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFE44195.1 - 0.25 10.1 0.0 0.48 9.2 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PCI PF01399.22 EFE44196.1 - 1.3e-11 44.7 0.0 3.5e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.4 EFE44196.1 - 2.1e-06 27.2 0.0 4.1e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TFIIF_beta PF02270.10 EFE44197.1 - 6.2e-74 249.2 14.9 2.7e-60 204.4 7.0 2.1 1 1 1 2 2 2 2 Transcription initiation factor IIF, beta subunit zf-CCCH PF00642.19 EFE44198.1 - 4.7e-08 32.5 23.4 0.0047 16.5 0.0 5.3 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) bZIP_Maf PF03131.12 EFE44199.1 - 1.1e-05 25.5 15.2 1.1e-05 25.5 10.5 2.9 1 1 1 2 2 2 1 bZIP Maf transcription factor bZIP_2 PF07716.10 EFE44199.1 - 0.00012 21.8 11.9 0.00012 21.8 8.3 3.5 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.16 EFE44199.1 - 0.0022 17.9 14.8 0.0022 17.9 10.3 3.4 1 1 2 3 3 3 1 bZIP transcription factor DUF2205 PF10224.4 EFE44199.1 - 0.48 10.0 15.2 0.63 9.6 7.7 2.5 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) Mnd1 PF03962.10 EFE44199.1 - 2 8.0 18.3 1.4 8.5 11.1 1.8 1 1 0 1 1 1 0 Mnd1 family APG6 PF04111.7 EFE44199.1 - 4.7 6.1 18.4 9.3 5.1 12.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 RNA_pol_I_TF PF04090.7 EFE44200.1 - 5.5e-07 29.0 0.0 0.0003 20.1 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase I specific initiation factor ECM11 PF15463.1 EFE44201.1 - 2.4e-40 138.0 0.0 7.5e-40 136.4 0.0 1.9 1 0 0 1 1 1 1 Extracellular mutant protein 11 zf-RING_2 PF13639.1 EFE44202.1 - 3.3e-08 33.2 3.9 5.6e-08 32.4 2.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFE44202.1 - 0.0036 17.3 1.8 0.007 16.4 1.3 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EFE44202.1 - 0.014 15.0 3.8 0.023 14.4 2.6 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFE44202.1 - 0.065 13.2 3.8 0.11 12.5 2.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE44202.1 - 0.072 12.7 5.0 0.12 12.0 3.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.1 EFE44202.1 - 0.11 12.2 3.9 0.19 11.4 2.7 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 AMP-binding PF00501.23 EFE44203.1 - 3.3e-69 233.2 0.0 4.9e-69 232.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 EFE44203.1 - 4.5e-13 49.2 0.1 1.1e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep PF00132.19 EFE44203.1 - 8.5e-12 44.0 7.5 1.8e-06 27.1 0.1 7.2 7 1 0 7 7 7 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFE44203.1 - 4.9e-08 32.3 12.2 0.025 14.1 0.0 5.5 4 1 1 5 5 5 4 Hexapeptide repeat of succinyl-transferase AMP-binding_C PF13193.1 EFE44203.1 - 0.0024 18.7 0.0 0.03 15.2 0.0 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.11 EFE44204.1 - 4.3e-42 144.1 51.0 1.7e-41 142.1 32.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFE44204.1 - 5.6e-20 71.0 24.7 9.8e-20 70.2 17.1 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFE44204.1 - 1.2e-14 53.7 35.1 2.5e-13 49.4 11.8 3.3 2 1 1 3 3 3 3 Sugar (and other) transporter TMEMspv1-c74-12 PF11044.3 EFE44205.1 - 7.1 6.2 5.9 12 5.5 4.1 1.4 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Fungal_trans_2 PF11951.3 EFE44206.1 - 2.6e-11 42.7 4.5 4.1e-11 42.1 3.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DEAD PF00270.24 EFE44207.1 - 1.3e-23 83.3 0.0 2.2e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE44207.1 - 8.5e-11 41.5 0.2 3e-10 39.8 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1998 PF09369.5 EFE44207.1 - 1.8e-09 37.9 0.1 5.3e-07 30.1 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) SKI PF01202.17 EFE44207.1 - 0.16 11.8 0.0 4.2 7.2 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase APH PF01636.18 EFE44208.1 - 0.0021 17.8 0.0 0.033 13.9 0.0 2.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family PI3_PI4_kinase PF00454.22 EFE44208.1 - 0.038 13.4 0.1 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase R3H-assoc PF13902.1 EFE44208.1 - 0.077 12.9 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 R3H-associated N-terminal domain Ran_BP1 PF00638.13 EFE44209.1 - 6.9e-15 55.1 0.0 1.7e-08 34.5 0.1 2.4 2 0 0 2 2 2 2 RanBP1 domain HSP70 PF00012.15 EFE44210.1 - 9.1e-06 23.8 0.0 0.00083 17.3 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein ADIP PF11559.3 EFE44211.1 - 0.003 17.4 3.0 0.0066 16.3 2.1 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF972 PF06156.8 EFE44211.1 - 0.0064 16.8 0.6 0.045 14.0 0.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF972) bZIP_2 PF07716.10 EFE44211.1 - 0.87 9.4 10.6 1.8 8.4 0.1 3.1 2 1 1 3 3 3 0 Basic region leucine zipper AIG1 PF04548.11 EFE44212.1 - 1.2e-08 34.3 0.0 2.9e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 EFE44212.1 - 4.1e-08 33.1 0.2 4.5e-07 29.8 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFE44212.1 - 9.5e-05 21.6 0.2 0.00032 19.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Septin PF00735.13 EFE44212.1 - 0.00067 18.7 0.0 0.00067 18.7 0.0 2.2 2 1 0 2 2 2 1 Septin FeoB_N PF02421.13 EFE44212.1 - 0.00096 18.4 0.4 0.0024 17.1 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EFE44212.1 - 0.0017 18.2 14.0 0.016 15.0 0.0 3.8 2 2 1 3 3 2 2 Dynamin family SRPRB PF09439.5 EFE44212.1 - 0.0023 17.1 0.1 0.0086 15.3 0.0 1.9 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Viral_helicase1 PF01443.13 EFE44212.1 - 0.0072 15.8 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IIGP PF05049.8 EFE44212.1 - 0.0076 15.1 0.0 0.016 14.0 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Miro PF08477.8 EFE44212.1 - 0.0093 16.4 0.0 0.0093 16.4 0.0 2.4 3 0 0 3 3 2 1 Miro-like protein DUF4407 PF14362.1 EFE44212.1 - 0.012 14.6 11.9 0.017 14.0 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_22 PF13401.1 EFE44212.1 - 0.027 14.5 3.5 0.036 14.2 0.0 2.7 2 2 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EFE44212.1 - 0.035 12.9 0.1 0.035 12.9 0.1 2.4 4 0 0 4 4 4 0 NB-ARC domain ABC_tran PF00005.22 EFE44212.1 - 0.073 13.3 0.0 0.073 13.3 0.0 2.7 2 1 0 2 2 1 0 ABC transporter AAA_29 PF13555.1 EFE44212.1 - 0.11 12.0 1.0 0.2 11.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_33 PF13671.1 EFE44212.1 - 0.2 11.5 2.5 0.31 10.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 EFE44212.1 - 0.32 10.4 0.1 0.32 10.4 0.1 2.3 2 1 0 2 2 1 0 FtsK/SpoIIIE family Gp58 PF07902.6 EFE44212.1 - 0.45 8.6 6.9 0.64 8.1 4.8 1.1 1 0 0 1 1 1 0 gp58-like protein AAA_16 PF13191.1 EFE44212.1 - 0.48 10.3 2.9 5.7 6.8 0.0 2.8 2 1 0 3 3 3 0 AAA ATPase domain GTP_EFTU PF00009.22 EFE44212.1 - 0.49 9.8 5.5 0.32 10.3 0.6 2.7 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 EFE44212.1 - 1 8.8 6.3 3 7.3 1.2 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein SRP54 PF00448.17 EFE44212.1 - 1.8 7.9 5.5 10 5.5 0.0 3.1 2 2 2 4 4 4 0 SRP54-type protein, GTPase domain AAA_17 PF13207.1 EFE44212.1 - 4.2 8.1 9.4 0.57 11.0 0.1 2.7 2 2 0 2 2 2 0 AAA domain V_ATPase_I PF01496.14 EFE44212.1 - 5.6 4.6 10.0 7.5 4.2 6.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fzo_mitofusin PF04799.8 EFE44212.1 - 6 6.2 11.4 0.42 9.9 1.0 2.7 1 1 1 2 2 2 0 fzo-like conserved region Cu-oxidase_2 PF07731.9 EFE44213.1 - 6.1e-40 135.9 9.7 3e-36 123.9 0.0 4.5 4 1 0 4 4 4 3 Multicopper oxidase Cu-oxidase_3 PF07732.10 EFE44213.1 - 7.7e-37 125.6 0.6 6e-35 119.5 1.3 2.6 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.17 EFE44213.1 - 5.7e-26 91.3 0.0 1.9e-25 89.6 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase IBR PF01485.16 EFE44215.1 - 0.00073 19.3 6.3 0.00073 19.3 4.4 4.8 5 1 0 5 5 5 2 IBR domain Dicty_REP PF05086.7 EFE44215.1 - 0.2 9.3 0.6 0.33 8.6 0.4 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein adh_short PF00106.20 EFE44216.1 - 7.3e-56 188.6 5.6 2.5e-27 95.8 0.1 2.3 2 0 0 2 2 2 2 short chain dehydrogenase MaoC_dehydratas PF01575.14 EFE44216.1 - 1.5e-30 105.1 0.0 2.7e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.5 EFE44216.1 - 6.4e-25 87.8 1.8 2.1e-11 43.7 0.0 2.6 2 1 0 2 2 2 2 KR domain adh_short_C2 PF13561.1 EFE44216.1 - 3.7e-16 59.6 0.9 3.2e-08 33.6 0.0 3.0 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase THF_DHG_CYH_C PF02882.14 EFE44216.1 - 9.4e-05 21.5 0.7 0.016 14.3 0.4 2.5 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.16 EFE44216.1 - 0.0015 18.0 0.7 0.91 8.9 0.1 2.7 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 EFE44216.1 - 0.45 10.1 5.0 8 6.0 0.1 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Fungal_trans PF04082.13 EFE44219.1 - 8.1e-36 123.2 0.0 3.5e-34 117.8 0.0 2.6 2 0 0 2 2 2 2 Fungal specific transcription factor domain SAPS PF04499.10 EFE44219.1 - 0.059 11.9 2.8 3.2 6.2 0.0 2.3 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Ax_dynein_light PF10211.4 EFE44220.1 - 1.9 8.3 15.6 2.1 8.1 10.8 1.0 1 0 0 1 1 1 0 Axonemal dynein light chain RNA_pol_Rpc4 PF05132.9 EFE44220.1 - 5.4 7.0 12.3 5.9 6.8 8.6 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 Glyco_hydro_18 PF00704.23 EFE44221.1 - 1e-31 110.6 0.0 1.5e-31 110.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Hce2 PF14856.1 EFE44221.1 - 8e-28 96.2 0.3 2.5e-27 94.6 0.2 1.9 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor LysM PF01476.15 EFE44221.1 - 4.1e-05 23.3 2.9 0.064 13.1 0.1 2.9 3 0 0 3 3 3 2 LysM domain Chitin_bind_1 PF00187.14 EFE44221.1 - 0.00026 20.8 4.3 0.00026 20.8 3.0 2.7 2 0 0 2 2 2 1 Chitin recognition protein PigN PF04987.9 EFE44223.1 - 1.1e-160 535.0 27.4 2.1e-160 534.2 19.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Csm1 PF12539.3 EFE44223.1 - 5.4e-25 87.7 0.2 2.8e-24 85.3 0.1 2.3 3 0 0 3 3 1 1 Chromosome segregation protein Csm1/Pcs1 Phosphodiest PF01663.17 EFE44223.1 - 9.8e-12 44.8 0.4 5.5e-10 39.1 0.0 2.4 1 1 1 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFE44223.1 - 1.5e-08 34.2 0.0 2.5e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Mnd1 PF03962.10 EFE44223.1 - 0.016 14.8 6.5 0.04 13.5 4.5 1.6 1 0 0 1 1 1 0 Mnd1 family V_ATPase_I PF01496.14 EFE44223.1 - 0.038 11.8 6.3 0.062 11.1 4.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2968 PF11180.3 EFE44223.1 - 0.043 13.1 13.8 0.09 12.1 9.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Spc7 PF08317.6 EFE44223.1 - 0.055 12.1 15.1 0.1 11.2 10.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Lge1 PF11488.3 EFE44223.1 - 0.058 13.5 6.4 0.18 12.0 4.4 1.8 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 IncA PF04156.9 EFE44223.1 - 0.071 12.7 13.6 0.22 11.0 9.4 1.9 1 0 0 1 1 1 0 IncA protein Allexi_40kDa PF05549.6 EFE44223.1 - 0.22 10.7 6.6 0.43 9.8 4.6 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein Baculo_PEP_C PF04513.7 EFE44223.1 - 0.41 10.4 6.6 0.88 9.3 4.6 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 EFE44223.1 - 0.45 9.6 6.0 0.75 8.9 4.1 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Spc42p PF11544.3 EFE44223.1 - 0.47 10.4 9.8 0.12 12.3 3.8 2.3 1 1 1 2 2 2 0 Spindle pole body component Spc42p DUF3450 PF11932.3 EFE44223.1 - 0.54 9.4 14.1 1.2 8.3 9.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) COG6 PF06419.6 EFE44223.1 - 0.73 7.8 13.0 1 7.4 9.0 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Cluap1 PF10234.4 EFE44223.1 - 0.81 8.8 13.9 1.5 7.9 9.7 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF3138 PF11336.3 EFE44223.1 - 1.9 6.5 9.1 3.4 5.7 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) APG6 PF04111.7 EFE44223.1 - 3.3 6.6 16.3 7.5 5.4 11.3 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1423 PF07227.6 EFE44223.1 - 3.9 6.0 10.6 7.1 5.1 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) TPR_MLP1_2 PF07926.7 EFE44223.1 - 5 6.8 25.9 0.088 12.5 12.9 1.8 2 0 0 2 2 1 0 TPR/MLP1/MLP2-like protein TEX13 PF15186.1 EFE44223.1 - 5.3 6.6 11.0 12 5.4 7.1 1.9 1 1 1 2 2 2 0 Testis-expressed sequence 13 protein family Med9 PF07544.8 EFE44223.1 - 5.8 6.7 17.2 1.9 8.2 7.9 2.6 2 1 1 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 AAA PF00004.24 EFE44224.1 - 1.4e-37 128.8 0.0 4.3e-37 127.2 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EFE44224.1 - 6.8e-06 25.9 0.0 1.7e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFE44224.1 - 1.3e-05 24.9 0.1 0.00022 20.9 0.0 2.9 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EFE44224.1 - 1.3e-05 25.9 0.3 6.8e-05 23.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFE44224.1 - 2e-05 24.6 0.1 0.00048 20.1 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFE44224.1 - 2.1e-05 24.6 0.3 0.00062 19.9 0.1 2.8 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 EFE44224.1 - 3.8e-05 22.8 0.0 6.7e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 EFE44224.1 - 0.00013 21.9 0.0 0.00033 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.1 EFE44224.1 - 0.00019 20.8 0.1 0.028 13.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EFE44224.1 - 0.00021 20.7 0.0 0.00046 19.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 EFE44224.1 - 0.00034 20.4 0.0 0.0007 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.1 EFE44224.1 - 0.00054 20.0 0.0 0.0018 18.3 0.0 1.8 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.16 EFE44224.1 - 0.00088 18.4 0.1 0.0017 17.5 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EFE44224.1 - 0.0013 18.9 0.0 0.004 17.2 0.0 2.0 1 1 1 2 2 2 1 RNA helicase Zeta_toxin PF06414.7 EFE44224.1 - 0.002 17.2 0.0 0.0043 16.1 0.0 1.7 1 1 0 1 1 1 1 Zeta toxin AAA_19 PF13245.1 EFE44224.1 - 0.0021 17.7 0.0 0.024 14.3 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain NACHT PF05729.7 EFE44224.1 - 0.0027 17.4 0.0 0.01 15.4 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.1 EFE44224.1 - 0.0033 17.3 0.0 0.0073 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.12 EFE44224.1 - 0.0038 16.1 0.0 0.0066 15.3 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_18 PF13238.1 EFE44224.1 - 0.0058 16.9 0.2 0.016 15.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.1 EFE44224.1 - 0.0061 16.1 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 EFE44224.1 - 0.007 15.8 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_11 PF13086.1 EFE44224.1 - 0.0094 15.5 0.2 0.051 13.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 EFE44224.1 - 0.02 15.1 0.3 0.072 13.3 0.0 2.1 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.8 EFE44224.1 - 0.034 13.0 0.0 0.071 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Rad17 PF03215.10 EFE44224.1 - 0.048 12.3 0.0 0.083 11.5 0.0 1.5 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein CPT PF07931.7 EFE44224.1 - 0.052 13.1 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Arch_ATPase PF01637.13 EFE44224.1 - 0.062 12.9 0.3 0.24 11.0 0.0 2.0 2 1 1 3 3 2 0 Archaeal ATPase NB-ARC PF00931.17 EFE44224.1 - 0.074 11.8 0.2 0.19 10.5 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain KaiC PF06745.8 EFE44224.1 - 0.095 11.8 0.0 0.48 9.5 0.0 2.0 1 1 1 2 2 2 0 KaiC UPF0079 PF02367.12 EFE44224.1 - 0.11 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Viral_helicase1 PF01443.13 EFE44224.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Cys_Met_Meta_PP PF01053.15 EFE44225.1 - 3.1e-135 450.4 0.0 4.8e-135 449.7 0.0 1.3 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EFE44225.1 - 0.00012 21.2 0.0 0.00036 19.6 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family SelA PF03841.8 EFE44225.1 - 0.001 17.8 0.1 0.0022 16.7 0.0 1.5 1 1 0 1 1 1 1 L-seryl-tRNA selenium transferase Beta_elim_lyase PF01212.16 EFE44225.1 - 0.0012 18.1 0.0 0.004 16.3 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase MFS_1 PF07690.11 EFE44226.1 - 8e-37 126.7 31.7 3.7e-24 85.1 10.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MTP18 PF10558.4 EFE44228.1 - 7e-66 220.7 0.1 1.1e-65 220.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF2611 PF11022.3 EFE44229.1 - 1.8e-13 50.3 0.2 1.9e-13 50.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) AAT PF03417.11 EFE44230.1 - 3.7e-31 108.3 0.0 4.7e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase ACPS PF01648.15 EFE44231.1 - 5e-18 64.9 0.0 8.7e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily APH PF01636.18 EFE44232.1 - 4.7e-05 23.2 0.0 5.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family APH PF01636.18 EFE44233.1 - 4e-07 30.0 0.0 6.4e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE44233.1 - 0.014 14.0 0.1 0.04 12.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) DUF3515 PF12028.3 EFE44233.1 - 0.034 13.3 0.0 0.085 12.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3515) EcKinase PF02958.15 EFE44233.1 - 0.07 12.2 0.0 0.45 9.6 0.0 2.1 2 0 0 2 2 2 0 Ecdysteroid kinase Choline_kinase PF01633.15 EFE44233.1 - 0.075 12.6 0.0 0.18 11.3 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF505 PF04458.7 EFE44233.1 - 0.098 10.7 0.0 0.13 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) APH PF01636.18 EFE44234.1 - 2e-06 27.7 0.1 0.055 13.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EFE44234.1 - 2.9e-06 26.4 0.0 0.00069 18.7 0.0 2.1 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EFE44234.1 - 0.00063 19.1 0.0 0.00096 18.5 0.0 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 EFE44234.1 - 0.0071 15.5 0.1 0.0096 15.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.15 EFE44234.1 - 0.033 13.7 0.0 3.1 7.3 0.0 2.2 1 1 1 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.20 EFE44234.1 - 0.082 12.0 0.1 0.12 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein kinase domain F-box PF00646.28 EFE44235.1 - 0.029 14.0 0.5 0.029 14.0 0.4 2.3 2 0 0 2 2 2 0 F-box domain PHP PF02811.14 EFE44236.1 - 2.5e-07 30.6 0.0 5.1e-07 29.6 0.0 1.5 1 1 0 1 1 1 1 PHP domain IFP_35_N PF07334.8 EFE44236.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID PF07941.6 EFE44237.1 - 0.05 13.8 0.5 0.072 13.3 0.3 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain AA_permease PF00324.16 EFE44238.1 - 1e-125 419.7 46.5 1.3e-125 419.4 32.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE44238.1 - 3.4e-23 81.8 54.6 4.8e-23 81.3 37.9 1.1 1 0 0 1 1 1 1 Amino acid permease FKBP_C PF00254.23 EFE44240.1 - 5.7e-12 45.5 0.0 7.3e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase F-box PF00646.28 EFE44241.1 - 0.0023 17.5 0.4 0.0063 16.1 0.2 1.7 1 0 0 1 1 1 1 F-box domain DUF4604 PF15377.1 EFE44243.1 - 0.05 13.8 10.5 0.063 13.4 7.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF3027 PF11228.3 EFE44243.1 - 0.066 12.8 0.9 0.072 12.7 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) AAA_13 PF13166.1 EFE44243.1 - 0.12 10.8 4.1 0.13 10.7 2.8 1.0 1 0 0 1 1 1 0 AAA domain Senescence_reg PF04520.8 EFE44243.1 - 0.15 12.5 5.6 0.18 12.2 3.9 1.1 1 0 0 1 1 1 0 Senescence regulator Dicty_REP PF05086.7 EFE44243.1 - 0.27 8.9 4.0 0.3 8.8 2.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Nop53 PF07767.6 EFE44243.1 - 0.39 9.6 17.1 0.46 9.4 11.9 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Mpp10 PF04006.7 EFE44243.1 - 0.42 8.9 13.5 0.47 8.7 9.4 1.0 1 0 0 1 1 1 0 Mpp10 protein Sin_N PF04801.8 EFE44243.1 - 1.7 7.3 8.2 1.9 7.2 5.7 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Spt5_N PF11942.3 EFE44243.1 - 2.5 8.7 9.9 3.4 8.3 6.8 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal RNA_polI_A34 PF08208.6 EFE44243.1 - 4 7.0 15.4 4.9 6.7 10.7 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1168 PF06658.7 EFE44243.1 - 5.7 6.4 21.1 8.2 5.9 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) FLO_LFY PF01698.11 EFE44243.1 - 6.6 5.4 10.4 7.7 5.2 7.2 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein GAGA_bind PF06217.7 EFE44245.1 - 0.04 13.8 5.6 0.042 13.8 3.9 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Med19 PF10278.4 EFE44245.1 - 0.044 13.4 13.4 0.054 13.1 9.3 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 BLVR PF06375.6 EFE44245.1 - 0.1 12.3 15.5 0.13 12.0 10.8 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) SR-25 PF10500.4 EFE44245.1 - 0.18 11.2 15.3 0.21 11.0 10.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNase_H2-Ydr279 PF09468.5 EFE44245.1 - 0.22 10.6 7.6 0.22 10.6 5.3 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Peptidase_S49_N PF08496.5 EFE44245.1 - 0.74 9.5 9.1 0.89 9.3 6.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal POPLD PF08170.7 EFE44245.1 - 0.8 9.5 3.8 1.2 9.0 2.6 1.3 1 0 0 1 1 1 0 POPLD (NUC188) domain DUF3043 PF11241.3 EFE44245.1 - 0.81 9.2 5.5 1 8.9 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) TSGP1 PF07771.6 EFE44245.1 - 1.3 8.9 11.1 1.9 8.3 7.7 1.3 1 0 0 1 1 1 0 Tick salivary peptide group 1 DUF1682 PF07946.9 EFE44245.1 - 1.7 7.4 12.3 2 7.2 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RNA_polI_A34 PF08208.6 EFE44245.1 - 1.7 8.2 19.5 2.2 7.8 13.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RNA_pol_Rpc4 PF05132.9 EFE44245.1 - 2.4 8.1 7.9 3.3 7.6 5.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 NARP1 PF12569.3 EFE44245.1 - 5.5 5.6 12.2 6.2 5.4 8.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 zf-UBR PF02207.15 EFE44248.1 - 1.5e-14 53.4 20.0 1.5e-14 53.4 13.8 2.3 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 EFE44248.1 - 7.1e-05 22.4 0.0 0.00023 20.8 0.0 1.9 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS TPR_12 PF13424.1 EFE44249.1 - 6.4e-11 42.0 0.2 0.001 18.9 0.0 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFE44249.1 - 1.9e-10 39.7 0.3 0.0067 16.1 0.1 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFE44249.1 - 6.9e-10 38.0 0.9 0.079 12.9 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 EFE44249.1 - 1.1e-09 37.7 0.2 0.012 15.1 0.0 3.7 2 1 1 3 3 3 3 TPR repeat TPR_14 PF13428.1 EFE44249.1 - 4e-09 36.3 0.1 0.33 11.7 0.0 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFE44249.1 - 1.6e-08 34.7 0.0 0.04 14.2 0.0 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFE44249.1 - 9e-07 28.2 4.9 0.41 10.5 0.1 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat NB-ARC PF00931.17 EFE44249.1 - 5.7e-05 22.1 0.0 0.0001 21.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 EFE44249.1 - 0.0018 18.4 0.0 0.005 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain TPR_1 PF00515.23 EFE44249.1 - 0.0025 17.3 0.5 0.61 9.7 0.1 3.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE44249.1 - 0.0041 17.7 0.0 34 5.2 0.0 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat PPR PF01535.15 EFE44249.1 - 0.042 13.8 1.2 28 4.9 0.0 4.2 4 0 0 4 4 4 0 PPR repeat TPR_6 PF13174.1 EFE44249.1 - 0.066 13.7 1.3 42 4.8 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFE44249.1 - 0.11 12.4 0.0 57 3.8 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR_3 PF13812.1 EFE44249.1 - 0.12 12.6 0.2 38 4.9 0.0 4.0 4 0 0 4 4 3 0 Pentatricopeptide repeat domain Mur_ligase_M PF08245.7 EFE44250.1 - 0.00028 20.9 1.7 0.0029 17.6 0.1 3.1 3 1 0 3 3 3 1 Mur ligase middle domain CENP-S PF15630.1 EFE44251.1 - 1.8e-10 40.8 0.0 2.1e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Kinetochore component CENP-S PGA2 PF07543.7 EFE44252.1 - 6.7e-34 116.6 1.0 7.9e-34 116.4 0.7 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 CCD PF07860.6 EFE44252.1 - 0.0065 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 WisP family C-Terminal Region Remorin_C PF03763.8 EFE44252.1 - 0.087 12.3 0.4 0.087 12.3 0.3 2.0 2 0 0 2 2 2 0 Remorin, C-terminal region MARVEL PF01284.18 EFE44253.1 - 0.0003 20.6 12.8 0.00062 19.6 8.8 1.6 1 1 1 2 2 2 1 Membrane-associating domain DUF4231 PF14015.1 EFE44253.1 - 0.023 14.6 1.5 0.092 12.7 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) GPI-anchored PF10342.4 EFE44254.1 - 0.053 13.9 0.1 0.23 11.9 0.0 2.0 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF2235 PF09994.4 EFE44255.1 - 8.2e-93 310.7 0.0 1.1e-92 310.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) An_peroxidase PF03098.10 EFE44256.1 - 1.3e-93 314.2 0.0 8e-73 245.6 0.0 2.2 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.17 EFE44257.1 - 6.1e-07 28.3 0.0 2.9e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 Cytochrome P450 Hexapep PF00132.19 EFE44258.1 - 8.1e-06 25.1 10.0 0.00083 18.7 2.5 4.2 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFE44258.1 - 3.3e-05 23.3 2.3 0.0029 17.1 0.4 2.7 1 1 1 2 2 2 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.7 EFE44258.1 - 0.039 12.5 0.2 0.05 12.1 0.1 1.1 1 0 0 1 1 1 0 L-fucokinase Arrestin_C PF02752.17 EFE44259.1 - 8.8e-18 64.7 0.0 3e-17 62.9 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EFE44259.1 - 1.7e-10 40.9 0.0 3.5e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain FCH PF00611.18 EFE44260.1 - 0.0027 17.8 1.3 0.008 16.3 0.0 2.3 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain PH PF00169.24 EFE44260.1 - 0.074 13.2 0.0 0.22 11.7 0.0 1.8 1 1 0 1 1 1 0 PH domain NCD2 PF04905.8 EFE44260.1 - 0.27 11.0 0.1 0.27 11.0 0.1 1.9 2 0 0 2 2 2 0 NAB conserved region 2 (NCD2) Spore_III_AB PF09548.5 EFE44260.1 - 1.2 8.8 4.6 17 5.0 0.2 2.6 3 0 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Glyoxalase PF00903.20 EFE44262.1 - 2.1e-34 118.2 0.0 1.6e-16 60.4 0.0 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EFE44262.1 - 3.7e-31 107.9 0.1 2.6e-15 56.9 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 EFE44262.1 - 4.7e-17 61.9 0.0 4.2e-08 33.1 0.0 3.8 2 2 1 3 3 3 3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 EFE44262.1 - 9.5e-07 28.8 0.0 0.0082 16.0 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase-like domain Kin17_mid PF10357.4 EFE44263.1 - 1.2e-46 157.4 1.5 2.6e-46 156.3 1.0 1.5 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.2 EFE44263.1 - 3e-05 24.0 0.9 7.6e-05 22.7 0.6 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EFE44263.1 - 0.00011 22.2 0.3 0.00011 22.2 0.2 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding MTBP_mid PF14919.1 EFE44263.1 - 0.0013 17.4 0.5 0.0018 17.0 0.4 1.2 1 0 0 1 1 1 1 MDM2-binding zf-C2H2_2 PF12756.2 EFE44263.1 - 0.0094 16.0 3.0 0.014 15.4 0.3 2.2 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Glyco_hydro_2_N PF02837.13 EFE44264.1 - 1.7e-09 37.4 0.0 3.4e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 EFE44264.1 - 2.4e-09 37.6 1.1 2e-08 34.6 0.0 2.8 3 1 0 3 3 3 1 Glycosyl hydrolases family 2 DUF3344 PF11824.3 EFE44264.1 - 0.015 14.6 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3344) DNA_circ_N PF07157.7 EFE44264.1 - 0.018 15.1 0.0 4.2 7.5 0.0 3.0 2 0 0 2 2 2 0 DNA circularisation protein N-terminus Cu-oxidase_3 PF07732.10 EFE44264.1 - 0.062 13.0 0.6 1.5 8.5 0.1 2.7 2 0 0 2 2 2 0 Multicopper oxidase Ank_2 PF12796.2 EFE44265.1 - 2.4e-78 258.5 14.3 2.7e-17 62.8 0.2 7.1 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 EFE44265.1 - 9.5e-76 246.0 19.1 4e-08 32.6 0.0 12.2 12 0 0 12 12 12 12 Ankyrin repeat Ank_4 PF13637.1 EFE44265.1 - 4.3e-63 208.6 15.3 1.2e-10 41.5 0.1 8.4 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE44265.1 - 6.9e-57 183.7 16.2 1.3e-06 28.0 0.0 12.2 12 0 0 12 12 12 11 Ankyrin repeat Ank_5 PF13857.1 EFE44265.1 - 1.2e-51 171.5 15.0 5.8e-08 32.7 0.0 10.0 5 2 5 10 10 10 10 Ankyrin repeats (many copies) Fe-ADH PF00465.14 EFE44266.1 - 1.2e-102 343.3 0.0 1.5e-102 342.9 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 EFE44266.1 - 4.2e-17 62.2 0.0 2e-13 50.2 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.1 EFE44266.1 - 0.00088 18.7 0.1 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein 2-Hacid_dh_C PF02826.14 EFE44267.1 - 1.2e-53 180.9 0.0 1.9e-53 180.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFE44267.1 - 1.1e-35 121.9 0.1 1.8e-35 121.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.1 EFE44267.1 - 0.0085 16.4 0.0 0.025 14.8 0.0 1.8 2 0 0 2 2 2 1 XdhC Rossmann domain AlaDh_PNT_C PF01262.16 EFE44267.1 - 0.018 14.6 2.0 0.56 9.7 0.7 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.10 EFE44267.1 - 0.02 14.7 0.7 0.055 13.3 0.0 2.0 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.20 EFE44267.1 - 0.091 12.2 0.3 0.93 9.0 0.0 2.7 2 0 0 2 2 2 0 ACT domain p450 PF00067.17 EFE44269.1 - 1e-59 202.3 0.0 2.7e-43 148.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Glyco_hydro_20 PF00728.17 EFE44270.1 - 1.6e-79 267.6 0.0 2.1e-79 267.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 EFE44270.1 - 1.3e-24 87.3 0.1 3.1e-24 86.0 0.1 1.7 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.10 EFE44270.1 - 0.00017 22.0 0.0 0.0024 18.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 zf-CCCH_2 PF14608.1 EFE44271.1 - 1e-06 28.5 51.1 4.1e-06 26.5 7.2 5.6 5 1 0 5 5 5 3 Zinc finger C-x8-C-x5-C-x3-H type Nab2 PF11517.3 EFE44271.1 - 0.0074 16.3 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Amino_oxidase PF01593.19 EFE44272.1 - 1e-10 41.3 0.0 2.9e-10 39.8 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Mago-bind PF09282.5 EFE44273.1 - 2.2e-13 49.4 1.9 4.9e-13 48.3 1.3 1.6 1 0 0 1 1 1 1 Mago binding Macoilin PF09726.4 EFE44273.1 - 1.4 7.0 12.1 1.7 6.8 8.4 1.1 1 0 0 1 1 1 0 Transmembrane protein GTP1_OBG PF01018.17 EFE44274.1 - 1.2e-34 119.2 2.8 2.4e-25 88.9 1.9 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.18 EFE44274.1 - 3.7e-21 75.2 0.0 9e-21 73.9 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE44274.1 - 8.5e-08 31.6 0.0 1.7e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B ArgK PF03308.11 EFE44274.1 - 0.0089 14.8 0.1 0.22 10.2 0.0 2.2 2 0 0 2 2 2 1 ArgK protein ABC_tran PF00005.22 EFE44274.1 - 0.081 13.2 2.0 0.12 12.6 0.0 2.2 2 0 0 2 2 2 0 ABC transporter Dynamin_N PF00350.18 EFE44274.1 - 0.16 11.7 0.1 7.2 6.3 0.1 2.6 2 1 1 3 3 3 0 Dynamin family UQ_con PF00179.21 EFE44275.1 - 3.1e-07 29.9 0.4 7.1e-07 28.7 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EFE44275.1 - 0.043 13.7 0.1 0.07 13.0 0.1 1.4 1 0 0 1 1 1 0 RWD domain FH2 PF02181.18 EFE44276.1 - 0.18 10.6 0.0 0.28 10.0 0.0 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain 2OG-FeII_Oxy_2 PF13532.1 EFE44277.1 - 2.5e-20 73.1 0.0 3.8e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CUE PF02845.11 EFE44277.1 - 4.7e-07 29.1 0.0 8.9e-07 28.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain Cupin_8 PF13621.1 EFE44278.1 - 1.4e-34 119.6 0.0 3.2e-34 118.5 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 EFE44278.1 - 4.2e-06 26.2 0.0 0.0016 17.7 0.0 2.5 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.17 EFE44278.1 - 0.073 13.3 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase Homeobox_KN PF05920.6 EFE44279.1 - 3.3e-14 52.3 0.2 9.8e-14 50.7 0.2 1.9 1 0 0 1 1 1 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.11 EFE44279.1 - 6.3e-05 22.7 0.0 0.00029 20.5 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.1 EFE44279.1 - 0.00011 22.3 28.4 0.0012 19.0 1.1 5.5 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFE44279.1 - 0.00026 21.1 22.2 0.013 15.8 1.1 5.2 3 1 0 3 3 3 2 Zinc finger, C2H2 type Homeobox PF00046.24 EFE44279.1 - 0.00032 20.2 0.0 0.00088 18.8 0.0 1.8 1 0 0 1 1 1 1 Homeobox domain HA PF03457.9 EFE44279.1 - 0.0085 16.1 0.4 0.043 13.9 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain zf-H2C2_2 PF13465.1 EFE44279.1 - 1.6 9.1 9.6 2.2 8.7 0.1 3.8 4 0 0 4 4 4 0 Zinc-finger double domain Fungal_trans PF04082.13 EFE44280.1 - 2.8e-29 101.7 0.0 7.8e-29 100.3 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain DnaJ PF00226.26 EFE44281.1 - 1.2e-21 76.1 1.4 2.3e-21 75.2 1.0 1.5 1 0 0 1 1 1 1 DnaJ domain Adenylsucc_synt PF00709.16 EFE44282.1 - 2e-149 497.8 0.1 2.3e-147 491.0 0.0 2.0 2 0 0 2 2 2 2 Adenylosuccinate synthetase DUF3354 PF11834.3 EFE44282.1 - 0.069 12.7 0.0 0.21 11.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3354) Ank_2 PF12796.2 EFE44283.1 - 4.6e-55 183.9 27.2 3.6e-07 30.4 0.1 12.3 3 3 8 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.25 EFE44283.1 - 5.8e-38 126.8 40.6 0.022 14.5 0.0 19.8 21 1 0 21 21 21 13 Ankyrin repeat Ank_4 PF13637.1 EFE44283.1 - 7.4e-24 83.6 19.9 0.05 14.1 0.0 13.8 13 2 0 13 13 13 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFE44283.1 - 1.1e-21 76.4 9.9 0.29 11.4 0.0 13.2 13 1 1 14 14 14 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE44283.1 - 2.3e-16 58.2 20.5 1.2 9.5 0.0 17.9 20 1 1 21 21 21 3 Ankyrin repeat DEAD PF00270.24 EFE44284.1 - 1.2e-40 138.7 0.1 1.8e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE44284.1 - 4e-19 68.2 0.5 8.1e-19 67.2 0.3 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE44284.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Aldolase_II PF00596.16 EFE44285.1 - 2.3e-43 147.9 0.1 3.2e-43 147.4 0.1 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PLAC8 PF04749.12 EFE44286.1 - 3e-12 47.0 2.2 3.7e-12 46.7 1.5 1.1 1 0 0 1 1 1 1 PLAC8 family CCER1 PF15482.1 EFE44286.1 - 5.8 6.4 5.9 0.32 10.6 0.7 1.3 1 1 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 RNase_H PF00075.19 EFE44287.1 - 1.4e-16 61.0 0.3 1.8e-16 60.6 0.2 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 EFE44287.1 - 2.7e-07 30.2 4.2 4.9e-05 23.0 2.9 2.8 1 1 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.19 EFE44288.1 - 5.2e-18 65.6 0.0 6.8e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 EFE44288.1 - 6.8e-09 35.3 0.1 4.6e-07 29.5 0.0 2.2 1 1 0 1 1 1 1 Reverse transcriptase-like TPT PF03151.11 EFE44290.1 - 2.1e-27 95.6 11.6 2.1e-27 95.6 8.0 3.1 3 1 0 3 3 3 1 Triose-phosphate Transporter family UAA PF08449.6 EFE44290.1 - 1.6e-06 27.2 20.7 2.8e-05 23.1 14.3 2.1 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 EFE44290.1 - 0.036 14.1 29.8 0.5 10.4 6.7 3.2 3 1 0 3 3 3 0 EamA-like transporter family RSS_P20 PF11757.3 EFE44291.1 - 0.068 13.3 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like TFIIB PF00382.14 EFE44292.1 - 9.8e-31 105.3 0.5 2.7e-17 62.3 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 EFE44292.1 - 1.5e-24 86.0 0.7 6e-24 84.0 0.0 2.5 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.7 EFE44292.1 - 0.00044 19.5 2.6 0.00094 18.4 1.8 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 EFE44292.1 - 0.00097 18.7 0.1 0.53 9.8 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain RRN7 PF11781.3 EFE44292.1 - 0.033 13.6 0.1 0.069 12.6 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 IBR PF01485.16 EFE44292.1 - 0.49 10.3 2.5 0.93 9.4 1.7 1.4 1 0 0 1 1 1 0 IBR domain E1-E2_ATPase PF00122.15 EFE44293.1 - 4e-39 134.0 0.1 5.2e-38 130.3 0.0 2.5 2 1 0 2 2 2 1 E1-E2 ATPase HMA PF00403.21 EFE44293.1 - 6.7e-35 119.0 2.2 1.4e-08 34.7 0.1 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.21 EFE44293.1 - 2.9e-34 119.3 0.3 5.1e-34 118.5 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFE44293.1 - 3e-18 66.6 0.0 5.9e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE44293.1 - 4.8e-05 23.0 1.8 0.00054 19.6 0.4 2.3 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase ERCC4 PF02732.10 EFE44294.1 - 3.5e-30 104.6 0.1 6.9e-30 103.6 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 EFE44294.1 - 0.00012 22.1 0.1 0.018 15.1 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix domain Ish1 PF10281.4 EFE44294.1 - 0.0095 15.9 0.0 7.8 6.6 0.0 3.4 3 0 0 3 3 3 2 Putative stress-responsive nuclear envelope protein Fungal_trans PF04082.13 EFE44295.1 - 1.2e-07 30.9 0.5 3.2e-07 29.4 0.4 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain PRP3 PF08572.5 EFE44296.1 - 1.9e-71 240.0 2.9 3e-71 239.3 2.0 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 EFE44296.1 - 2.5e-39 133.8 0.4 2.5e-39 133.8 0.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) RNA_pol_Rpb1_5 PF04998.12 EFE44297.1 - 2.8e-86 289.2 0.0 8.8e-86 287.5 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EFE44297.1 - 3.6e-62 209.1 0.1 8.2e-62 208.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 EFE44297.1 - 1.2e-34 119.3 0.0 4.4e-33 114.2 0.0 2.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 EFE44297.1 - 1.6e-17 63.2 0.0 6.4e-17 61.2 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.7 EFE44297.1 - 1.1e-11 44.5 4.1 4.4e-05 22.8 3.6 3.2 2 1 0 2 2 2 2 RNA polymerase Rpb1, domain 1 DUF1227 PF06777.6 EFE44298.1 - 4.1e-61 204.9 0.5 1.2e-60 203.4 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 EFE44298.1 - 5.8e-48 162.5 0.2 1.1e-47 161.6 0.1 1.5 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 EFE44298.1 - 8.8e-45 152.6 0.0 2.2e-44 151.3 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain SNF2_N PF00176.18 EFE44298.1 - 0.00023 20.0 0.0 0.0021 16.9 0.0 2.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 EFE44298.1 - 0.011 15.2 0.0 2.9 7.3 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase ResIII PF04851.10 EFE44298.1 - 0.037 13.8 0.5 0.55 10.0 0.4 2.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit U1snRNP70_N PF12220.3 EFE44298.1 - 0.12 12.7 1.2 0.48 10.7 0.9 2.0 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal AAA_11 PF13086.1 EFE44298.1 - 0.18 11.3 2.6 0.17 11.4 0.2 2.2 2 1 0 2 2 2 0 AAA domain Stomoxyn PF11585.3 EFE44298.1 - 0.19 11.5 0.1 0.84 9.4 0.1 2.0 2 0 0 2 2 2 0 Insect antimicrobial peptide, stomoxyn LCM PF04072.9 EFE44299.1 - 1.3e-21 77.0 0.0 2.7e-21 75.9 0.0 1.5 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase C1_1 PF00130.17 EFE44299.1 - 0.01 15.5 3.0 0.021 14.5 2.1 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.1 EFE44299.1 - 0.04 13.7 2.7 0.093 12.5 1.9 1.6 1 0 0 1 1 1 0 Ring finger domain SUN PF03856.8 EFE44300.1 - 1.4e-77 260.3 13.9 2e-77 259.8 9.6 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF605 PF04652.11 EFE44300.1 - 6.3 6.0 30.6 9.4 5.5 21.2 1.2 1 0 0 1 1 1 0 Vta1 like DUF572 PF04502.8 EFE44300.1 - 7.4 5.6 9.7 11 5.1 6.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Sec3_C PF09763.4 EFE44301.1 - 0.13 10.3 0.0 0.14 10.2 0.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 zf-CCCH PF00642.19 EFE44301.1 - 0.18 11.5 7.3 1.3 8.8 2.2 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 EFE44301.1 - 8.7 6.5 9.5 2.1 8.4 3.5 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type Ist1 PF03398.9 EFE44302.1 - 1.1e-30 106.1 0.4 9.9e-15 54.3 0.9 2.2 2 0 0 2 2 2 2 Regulator of Vps4 activity in the MVB pathway Peptidase_S28 PF05577.7 EFE44305.1 - 2.9e-56 190.8 0.6 4.9e-56 190.1 0.4 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase S28 DAHP_synth_2 PF01474.11 EFE44306.1 - 3.6e-144 480.3 0.0 4.7e-85 285.5 0.0 2.0 2 0 0 2 2 2 2 Class-II DAHP synthetase family AMP-binding PF00501.23 EFE44308.1 - 1.8e-64 217.7 0.0 2.3e-64 217.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE44308.1 - 3.2e-05 24.7 0.0 8.8e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TP_methylase PF00590.15 EFE44310.1 - 1.2e-20 74.0 0.1 1.9e-20 73.4 0.1 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TFIID-18kDa PF02269.11 EFE44311.1 - 3.7e-25 87.5 0.1 4.7e-24 84.0 0.1 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Aminotran_1_2 PF00155.16 EFE44312.1 - 9.4e-63 212.3 0.0 1.1e-62 212.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EFE44312.1 - 0.0057 14.9 0.1 0.013 13.8 0.0 1.5 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EFE44312.1 - 0.074 11.7 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Mmp37 PF09139.6 EFE44314.1 - 7.2e-137 455.8 0.0 8.9e-137 455.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 BIR PF00653.16 EFE44315.1 - 2.5e-40 136.7 8.1 3.7e-20 72.1 0.1 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C2H2_jaz PF12171.3 EFE44316.1 - 1.7e-07 31.1 0.3 3.5e-07 30.1 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFE44316.1 - 2.9e-06 27.2 0.5 7.5e-06 25.9 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 EFE44316.1 - 0.0023 18.1 0.4 0.0046 17.2 0.3 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 EFE44316.1 - 0.093 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) EVC2_like PF12297.3 EFE44316.1 - 0.12 10.9 5.4 0.17 10.4 3.7 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein F-box-like PF12937.2 EFE44317.1 - 0.00095 18.8 0.0 0.0022 17.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFE44317.1 - 0.0047 16.5 0.0 0.012 15.2 0.0 1.7 1 0 0 1 1 1 1 F-box domain AMP-binding PF00501.23 EFE44318.1 - 5.9e-31 107.2 0.0 8.2e-31 106.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE44319.1 - 2.8e-05 24.9 0.0 4.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ribosomal_L7Ae PF01248.21 EFE44321.1 - 4.2e-16 58.2 0.0 5.2e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Formyl_trans_N PF00551.14 EFE44322.1 - 6e-37 126.9 0.0 7.1e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase 2-ph_phosp PF04029.9 EFE44322.1 - 0.019 13.9 0.0 0.073 12.0 0.0 1.7 2 0 0 2 2 2 0 2-phosphosulpholactate phosphatase Afi1 PF07792.7 EFE44323.1 - 1.3e-45 154.9 0.1 3.4e-45 153.6 0.1 1.7 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.5 EFE44323.1 - 4.2e-37 126.2 0.0 6.9e-37 125.6 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 EFE44323.1 - 8e-08 31.1 0.0 0.045 12.2 0.0 3.6 2 1 1 3 3 3 2 Transport protein Avl9 DUF2347 PF09804.4 EFE44323.1 - 0.078 12.2 0.0 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) GSAP-16 PF14959.1 EFE44323.1 - 0.1 12.3 0.3 0.23 11.1 0.2 1.5 1 0 0 1 1 1 0 gamma-Secretase-activating protein C-term Peripla_BP_6 PF13458.1 EFE44323.1 - 0.21 10.9 0.0 0.34 10.1 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein EF-hand_6 PF13405.1 EFE44324.1 - 1.6e-14 52.3 1.4 4.1e-06 26.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 EFE44324.1 - 3.8e-14 52.5 4.1 3.1e-10 40.0 0.5 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 EFE44324.1 - 5.5e-13 47.2 2.6 1.7e-05 23.7 0.1 2.6 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.1 EFE44324.1 - 7.1e-10 37.7 3.7 0.00024 20.3 0.5 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 EFE44324.1 - 1.7e-06 27.5 2.0 0.042 13.4 0.1 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.1 EFE44324.1 - 0.0053 16.6 0.0 3.5 7.6 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain RabGAP-TBC PF00566.13 EFE44325.1 - 5.7e-33 114.1 0.0 5e-32 111.1 0.0 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain SET PF00856.23 EFE44328.1 - 2.4e-07 31.2 0.2 0.004 17.4 0.0 3.3 3 0 0 3 3 3 2 SET domain TPR_11 PF13414.1 EFE44328.1 - 0.0029 17.2 0.1 0.011 15.3 0.0 1.9 2 0 0 2 2 2 1 TPR repeat zf-MYND PF01753.13 EFE44328.1 - 0.036 13.9 5.6 0.11 12.3 3.9 1.9 1 0 0 1 1 1 0 MYND finger WD40 PF00400.27 EFE44329.1 - 6.7e-27 92.3 11.0 4.4e-08 32.7 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Glucosamine_iso PF01182.15 EFE44331.1 - 7.4e-59 198.8 0.0 8.7e-59 198.5 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase F-box PF00646.28 EFE44333.1 - 0.00038 20.0 0.0 0.0013 18.3 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFE44333.1 - 0.0022 17.6 0.0 0.0053 16.4 0.0 1.7 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.1 EFE44333.1 - 0.018 15.0 0.0 4.9 7.5 0.0 3.6 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.2 EFE44333.1 - 0.12 12.0 7.0 0.7 9.5 0.1 4.7 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE44333.1 - 0.22 11.3 4.4 6.1 6.6 0.0 4.4 4 2 1 5 5 5 0 Leucine rich repeat IDO PF01231.13 EFE44334.1 - 3.7e-38 131.0 0.0 3.5e-36 124.5 0.0 2.2 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase bcl-2I13 PF12201.3 EFE44334.1 - 0.11 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Bcl2-interacting killer, BH3-domain containing Glyco_hydro_16 PF00722.16 EFE44335.1 - 1.7e-06 27.4 0.2 2.7e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF4328 PF14219.1 EFE44335.1 - 0.48 9.7 3.0 0.18 11.0 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4328) TPR_2 PF07719.12 EFE44336.1 - 4.9e-11 41.6 7.4 0.0051 16.6 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFE44336.1 - 1.6e-10 40.1 2.4 0.0049 16.4 0.0 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFE44336.1 - 1.3e-09 37.8 7.0 0.00027 20.8 0.0 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFE44336.1 - 1.4e-09 37.0 0.3 0.029 14.1 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE44336.1 - 4e-09 35.9 4.7 9.5e-06 25.1 0.0 3.7 4 1 0 4 4 4 2 TPR repeat TPR_7 PF13176.1 EFE44336.1 - 4.8e-09 35.3 0.3 0.16 11.8 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFE44336.1 - 1.2e-05 25.5 0.4 0.11 12.8 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFE44336.1 - 0.0011 19.4 1.1 50 4.9 0.0 5.2 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFE44336.1 - 0.0096 15.8 0.5 31 4.6 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFE44336.1 - 0.03 14.9 0.8 19 6.0 0.0 3.8 4 1 1 5 5 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFE44336.1 - 0.033 14.6 11.9 0.89 10.1 0.1 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 EFE44336.1 - 0.086 13.0 0.2 1.4 9.3 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat Apc3 PF12895.2 EFE44336.1 - 0.22 11.6 9.9 0.23 11.6 0.5 3.8 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 AAA_16 PF13191.1 EFE44337.1 - 5.9e-05 23.1 0.0 0.00029 20.8 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 EFE44337.1 - 0.0033 17.0 0.0 0.0096 15.5 0.0 1.9 2 0 0 2 2 2 1 NACHT domain CLTH PF10607.4 EFE44338.1 - 2.1e-28 98.8 0.0 4.2e-28 97.8 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.23 EFE44338.1 - 3.1e-19 69.2 0.1 5.3e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.6 EFE44338.1 - 0.004 16.8 0.5 0.011 15.4 0.0 2.0 2 0 0 2 2 2 1 LisH Serglycin PF04360.7 EFE44338.1 - 6.4 6.4 9.5 1.4 8.6 2.3 2.6 2 0 0 2 2 2 0 Serglycin INO80_Ies4 PF08193.6 EFE44339.1 - 7.6e-52 176.4 36.6 7.6e-52 176.4 25.4 1.4 1 1 0 1 1 1 1 INO80 complex subunit Ies4 DUF1510 PF07423.6 EFE44339.1 - 0.18 11.1 16.3 0.065 12.5 8.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Ycf1 PF05758.7 EFE44339.1 - 0.33 8.6 3.9 0.4 8.3 2.7 1.1 1 0 0 1 1 1 0 Ycf1 DDHD PF02862.12 EFE44339.1 - 2.7 7.7 10.6 1.7 8.3 3.6 2.1 2 0 0 2 2 2 0 DDHD domain SRP-alpha_N PF04086.8 EFE44339.1 - 3.1 7.1 18.3 0.15 11.3 6.6 2.3 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DnaJ PF00226.26 EFE44340.1 - 5.8e-16 57.9 0.0 1.2e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain SAPS PF04499.10 EFE44341.1 - 4.1 5.9 15.3 0.29 9.7 0.0 2.3 2 1 0 2 2 2 0 SIT4 phosphatase-associated protein TMCO5 PF14992.1 EFE44342.1 - 0.026 13.6 1.4 0.033 13.3 1.0 1.2 1 0 0 1 1 1 0 TMCO5 family CASP_C PF08172.7 EFE44342.1 - 0.14 11.2 0.0 0.33 9.9 0.0 1.6 2 0 0 2 2 2 0 CASP C terminal MFS_1 PF07690.11 EFE44343.1 - 2.7e-21 75.6 57.4 1.5e-19 69.9 23.0 3.7 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFE44343.1 - 1.1e-09 37.0 7.4 3.4e-06 25.5 1.1 2.3 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sulfate_transp PF00916.15 EFE44344.1 - 4.4e-71 239.1 11.6 4.4e-71 239.1 8.1 1.9 1 1 1 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 EFE44344.1 - 3.2e-31 106.8 3.0 3.2e-31 106.8 2.1 3.2 4 1 1 5 5 5 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EFE44344.1 - 9.4e-07 28.2 0.0 1.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 STAS domain DUF2072 PF09845.4 EFE44344.1 - 0.19 11.6 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) PCDO_beta_N PF12391.3 EFE44345.1 - 0.17 11.3 0.5 0.17 11.3 0.3 1.8 2 0 0 2 2 2 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal DnaJ PF00226.26 EFE44346.1 - 3.6e-24 84.2 3.0 5.9e-24 83.5 2.1 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EFE44346.1 - 2.7e-22 78.4 0.1 7.7e-20 70.5 0.0 2.4 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EFE44346.1 - 5.2e-13 48.8 18.4 1e-12 47.9 12.7 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 EFE44346.1 - 0.28 10.8 10.2 0.4 10.3 1.6 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family URO-D PF01208.12 EFE44347.1 - 3.1e-110 368.3 0.0 3.7e-110 368.0 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) WD40 PF00400.27 EFE44348.1 - 7e-08 32.0 1.2 0.0012 18.6 0.5 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Pyocin_S PF06958.7 EFE44348.1 - 0.36 11.1 2.9 1.9 8.8 0.5 2.5 2 0 0 2 2 2 0 S-type Pyocin Ribosomal_L10 PF00466.15 EFE44349.1 - 1.1e-23 83.0 0.0 2.4e-23 81.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 EFE44349.1 - 1.2e-10 41.6 1.2 3.3e-10 40.2 0.2 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein PDEase_I PF00233.14 EFE44351.1 - 4.6e-38 131.3 0.0 6.8e-38 130.7 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PCI PF01399.22 EFE44353.1 - 4.1e-12 46.3 0.6 1.6e-10 41.1 0.0 3.0 2 0 0 2 2 2 1 PCI domain BAH PF01426.13 EFE44353.1 - 0.0075 16.0 0.1 0.03 14.0 0.1 1.8 1 1 0 1 1 1 1 BAH domain CENP-Q PF13094.1 EFE44355.1 - 2.1 8.3 11.3 1.4 8.9 5.0 2.4 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Acetyltransf_1 PF00583.19 EFE44356.1 - 1.2e-08 34.8 0.0 1.7e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFE44356.1 - 1.6e-05 25.0 0.0 2.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFE44356.1 - 0.0027 17.8 0.0 0.0047 17.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFE44356.1 - 0.016 15.0 0.0 0.021 14.7 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE44356.1 - 0.043 13.6 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFE44356.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein MFS_1 PF07690.11 EFE44357.1 - 7.6e-22 77.4 52.6 2.5e-17 62.6 26.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily APOC4 PF15119.1 EFE44357.1 - 0.084 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein C4 Pkinase PF00069.20 EFE44358.1 - 6.3e-21 74.6 0.0 8.2e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44358.1 - 6e-17 61.5 0.0 7.9e-17 61.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44358.1 - 7.9e-07 28.3 0.0 1.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 EFE44358.1 - 0.0095 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Ribosomal_S10 PF00338.17 EFE44358.1 - 0.02 14.7 0.1 0.065 13.0 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein S10p/S20e APH PF01636.18 EFE44358.1 - 0.028 14.1 0.2 0.067 12.9 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family NICE-3 PF07406.6 EFE44358.1 - 0.086 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 NICE-3 protein RNA_pol_Rpb6 PF01192.17 EFE44359.1 - 4.2e-09 36.0 0.4 1.3e-08 34.4 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb6 zf-C2H2 PF00096.21 EFE44360.1 - 1.2e-24 85.1 55.1 0.0022 18.2 0.5 11.4 11 1 1 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE44360.1 - 1.5e-24 84.4 44.6 0.0028 17.8 0.1 10.8 10 1 1 11 11 11 8 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFE44360.1 - 2.4e-15 55.9 49.1 0.00088 19.4 0.2 11.0 11 0 0 11 11 11 7 Zinc-finger double domain GAGA PF09237.6 EFE44360.1 - 0.00043 19.8 0.6 0.00043 19.8 0.4 2.4 2 0 0 2 2 2 1 GAGA factor zf-C2H2_jaz PF12171.3 EFE44360.1 - 0.00074 19.5 13.7 6.8 6.9 0.0 7.7 8 0 0 8 8 8 2 Zinc-finger double-stranded RNA-binding CHORD PF04968.7 EFE44360.1 - 0.15 12.3 14.6 3 8.1 0.6 4.7 3 1 1 4 4 4 0 CHORD zf-met PF12874.2 EFE44360.1 - 0.54 10.5 15.9 34 4.8 0.0 7.3 7 0 0 7 7 7 0 Zinc-finger of C2H2 type Zn_Tnp_IS1595 PF12760.2 EFE44360.1 - 5.2 6.9 11.2 0.67 9.8 1.3 3.8 3 0 0 3 3 3 0 Transposase zinc-ribbon domain PH PF00169.24 EFE44362.1 - 0.00025 21.2 0.0 0.0017 18.5 0.0 2.3 3 0 0 3 3 3 1 PH domain COPIIcoated_ERV PF07970.7 EFE44363.1 - 3.9e-67 226.1 0.0 1.8e-45 155.2 0.0 2.4 2 1 1 3 3 3 2 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 EFE44363.1 - 1.6e-34 117.7 0.0 4e-34 116.4 0.0 1.7 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) LRR_4 PF12799.2 EFE44364.1 - 4.5e-09 35.7 5.0 1.6e-05 24.3 0.2 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) TAP_C PF03943.8 EFE44364.1 - 2.7e-08 33.0 1.0 6.4e-08 31.8 0.7 1.6 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.1 EFE44364.1 - 0.0016 17.9 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 EFE44364.1 - 0.0018 17.9 0.2 0.0051 16.5 0.2 1.8 1 0 0 1 1 1 1 Leucine rich repeat NTF2 PF02136.15 EFE44364.1 - 0.0038 17.5 0.0 0.019 15.3 0.0 2.2 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_1 PF00560.28 EFE44364.1 - 0.0052 16.6 0.6 0.72 10.1 0.1 3.5 3 0 0 3 3 3 1 Leucine Rich Repeat Vps53_N PF04100.7 EFE44365.1 - 2.5e-105 352.3 8.9 5.1e-105 351.3 6.2 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal DUF2450 PF10475.4 EFE44365.1 - 7.2e-08 31.6 7.7 1.5e-07 30.6 5.3 1.4 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) COG2 PF06148.6 EFE44365.1 - 0.0014 18.5 1.3 0.0058 16.4 0.5 2.4 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.6 EFE44365.1 - 0.084 11.5 9.4 0.12 11.0 5.9 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF2400 PF09674.5 EFE44365.1 - 0.32 10.6 6.8 1.3 8.6 1.8 3.2 4 1 0 4 4 4 0 Protein of unknown function (DUF2400) HHH_5 PF14520.1 EFE44366.1 - 4.5e-05 23.5 0.1 0.00018 21.6 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain DUF4332 PF14229.1 EFE44366.1 - 0.026 14.5 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Asparaginase_II PF06089.7 EFE44366.1 - 0.047 12.3 0.0 0.072 11.7 0.0 1.3 1 0 0 1 1 1 0 L-asparaginase II DNA_pol_lambd_f PF10391.4 EFE44366.1 - 0.083 12.4 0.0 3.1 7.4 0.0 2.6 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda DEAD PF00270.24 EFE44367.1 - 4.1e-15 55.6 0.2 1.5e-14 53.8 0.1 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EFE44367.1 - 6.6e-06 26.0 0.0 2.9e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1524 PF07510.6 EFE44369.1 - 4.2e-14 52.5 0.0 5.4e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) HNH_4 PF13395.1 EFE44369.1 - 0.011 15.3 0.4 0.039 13.5 0.3 1.9 1 1 0 1 1 1 0 HNH endonuclease RrnaAD PF00398.15 EFE44370.1 - 0.0045 16.0 0.0 0.015 14.3 0.0 1.8 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase DUF4604 PF15377.1 EFE44371.1 - 4.3e-26 92.0 16.0 4.9e-26 91.8 11.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Cut8_N PF14482.1 EFE44371.1 - 8.1 6.5 10.9 2.5 8.1 0.3 3.5 3 1 0 3 3 3 0 Cut8 proteasome-binding domain Prp19 PF08606.6 EFE44372.1 - 5.3e-33 112.5 0.8 1e-32 111.6 0.5 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.27 EFE44372.1 - 2.2e-13 49.4 12.9 6.9e-07 28.9 0.0 7.1 8 0 0 8 8 8 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 EFE44372.1 - 1.8e-08 33.6 0.1 0.00046 19.1 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region eIF2A PF08662.6 EFE44372.1 - 3.9e-06 26.7 0.0 0.041 13.5 0.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 EFE44372.1 - 0.00037 18.8 0.0 0.14 10.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain DUF3312 PF11768.3 EFE44372.1 - 0.037 12.2 0.0 0.058 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) DUF3804 PF12707.2 EFE44372.1 - 0.045 13.3 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3804) zf-RING_5 PF14634.1 EFE44373.1 - 0.0005 19.7 1.8 0.00092 18.8 1.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFE44373.1 - 0.0094 15.9 3.2 0.026 14.5 2.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.16 EFE44373.1 - 0.019 14.8 1.3 0.045 13.6 0.9 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-RING_2 PF13639.1 EFE44373.1 - 0.052 13.3 0.9 0.097 12.5 0.6 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.20 EFE44373.1 - 0.27 10.9 2.8 1.8 8.3 2.4 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_L37ae PF01780.14 EFE44373.1 - 0.4 10.5 3.4 17 5.3 1.0 2.3 2 0 0 2 2 2 0 Ribosomal L37ae protein family zf-UBP PF02148.14 EFE44373.1 - 0.44 10.7 2.5 1.2 9.3 1.8 1.8 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein L51_S25_CI-B8 PF05047.11 EFE44374.1 - 1.8e-14 53.2 0.2 2.6e-14 52.6 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain U1snRNP70_N PF12220.3 EFE44375.1 - 2.2e-33 114.4 0.6 4e-33 113.5 0.4 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Ribosomal_L10 PF00466.15 EFE44376.1 - 1.5e-17 63.3 0.0 4e-17 61.9 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 Cyclin_N PF00134.18 EFE44377.1 - 9.5e-36 122.1 0.1 2.2e-35 120.9 0.1 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFE44377.1 - 1.1e-11 44.6 1.5 3.5e-11 43.0 1.0 1.9 1 1 0 1 1 1 1 Cyclin, C-terminal domain Acyl_transf_3 PF01757.17 EFE44378.1 - 6.4e-26 90.9 24.7 1.2e-25 90.0 17.2 1.5 1 1 0 1 1 1 1 Acyltransferase family Caps_synth_CapC PF14102.1 EFE44378.1 - 0.19 11.8 0.1 0.19 11.8 0.0 2.6 3 0 0 3 3 3 0 Capsule biosynthesis CapC Pyr_redox_2 PF07992.9 EFE44379.1 - 3e-13 50.1 0.0 4.2e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFE44379.1 - 0.001 17.6 0.0 0.0084 14.6 0.0 2.3 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.1 EFE44379.1 - 0.0034 17.3 0.1 0.0084 16.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFE44379.1 - 0.012 15.7 0.3 4.1 7.3 0.0 2.6 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFE44379.1 - 0.021 13.7 0.2 0.051 12.4 0.1 1.6 1 1 1 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.17 EFE44379.1 - 0.029 13.2 0.5 4.4 6.0 0.0 2.4 1 1 1 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.1 EFE44379.1 - 0.036 13.8 1.9 0.54 10.0 0.0 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding Thi4 PF01946.12 EFE44379.1 - 0.043 12.9 0.0 0.083 11.9 0.0 1.4 1 0 0 1 1 1 0 Thi4 family FKBP_C PF00254.23 EFE44383.1 - 1.5e-33 114.6 0.0 1.8e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cyt-b5 PF00173.23 EFE44384.1 - 1.4e-16 60.0 0.0 2e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Beta-lactamase PF00144.19 EFE44385.1 - 1.3e-29 103.2 0.1 1.7e-29 102.8 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Zip PF02535.17 EFE44386.1 - 8.7e-59 199.0 7.2 1e-58 198.8 5.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Tom37_C PF11801.3 EFE44387.1 - 5.8e-38 130.3 0.0 1.2e-37 129.3 0.0 1.5 2 0 0 2 2 2 1 Tom37 C-terminal domain WBP-1 PF11669.3 EFE44389.1 - 0.13 12.3 0.1 0.13 12.3 0.1 2.1 2 1 0 2 2 2 0 WW domain-binding protein 1 DUF4512 PF14975.1 EFE44389.1 - 0.77 10.6 2.8 1 10.2 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4512) Cytochrom_B558a PF05038.8 EFE44389.1 - 5.8 6.5 5.8 3.9 7.0 2.7 1.6 1 1 1 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit eIF3_subunit PF08597.5 EFE44391.1 - 0.05 13.1 0.2 0.05 13.1 0.1 2.2 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit NAPRTase PF04095.11 EFE44392.1 - 9.7e-53 178.9 0.1 3.2e-28 98.6 0.1 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF2960 PF11173.3 EFE44392.1 - 0.1 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2960) SNARE PF05739.14 EFE44393.1 - 8.1e-12 44.6 3.5 8.1e-12 44.6 2.4 2.4 2 1 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 EFE44393.1 - 2.3e-09 37.3 0.1 2.3e-09 37.3 0.0 2.9 1 1 2 3 3 3 1 Syntaxin Syntaxin_2 PF14523.1 EFE44393.1 - 2.8e-06 27.2 8.6 3e-06 27.2 0.3 3.0 1 1 2 3 3 3 1 Syntaxin-like protein Use1 PF09753.4 EFE44393.1 - 9.6e-06 25.2 5.5 1.3e-05 24.7 3.8 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Rifin_STEVOR PF02009.11 EFE44393.1 - 0.0026 17.4 3.7 0.0033 17.1 2.1 1.4 1 1 0 1 1 1 1 Rifin/stevor family Spectrin PF00435.16 EFE44393.1 - 0.0028 17.9 8.1 0.38 11.0 0.0 3.3 2 1 0 3 3 3 1 Spectrin repeat COG2 PF06148.6 EFE44393.1 - 0.0034 17.2 4.6 0.0065 16.3 0.1 2.8 1 1 1 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 TBPIP PF07106.8 EFE44393.1 - 0.009 15.5 6.7 0.54 9.7 0.0 2.3 1 1 0 2 2 2 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PTA_PTB PF01515.14 EFE44393.1 - 0.027 13.5 1.6 0.041 12.9 1.1 1.3 1 0 0 1 1 1 0 Phosphate acetyl/butaryl transferase Gp-FAR-1 PF05823.7 EFE44393.1 - 0.027 14.4 3.4 0.046 13.6 0.1 2.3 1 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) NEP PF10167.4 EFE44393.1 - 0.043 13.5 0.6 0.043 13.5 0.4 2.3 2 1 0 2 2 2 0 Uncharacterised conserved protein DUF912 PF06024.7 EFE44393.1 - 0.045 13.7 0.4 0.045 13.7 0.3 1.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MCPsignal PF00015.16 EFE44393.1 - 0.062 12.8 11.8 0.15 11.5 4.7 2.5 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.7 EFE44393.1 - 0.086 12.6 6.3 1.9 8.2 0.4 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) TSC22 PF01166.13 EFE44393.1 - 0.11 12.4 2.7 0.34 10.8 0.2 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family MT0933_antitox PF14013.1 EFE44393.1 - 0.12 12.5 1.0 0.45 10.6 0.1 2.5 2 1 0 2 2 2 0 MT0933-like antitoxin protein ISG65-75 PF11727.3 EFE44393.1 - 0.12 11.3 11.6 0.15 11.0 1.3 2.4 2 1 1 3 3 3 0 Invariant surface glycoprotein PBP1_TM PF14812.1 EFE44393.1 - 0.15 12.3 3.8 0.1 12.9 0.4 2.5 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3753 PF12575.3 EFE44393.1 - 0.16 11.7 3.4 0.38 10.5 2.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Baculo_11_kDa PF06143.6 EFE44393.1 - 0.2 11.0 5.4 0.85 9.0 3.7 2.1 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF3904 PF13044.1 EFE44393.1 - 0.22 9.9 3.2 0.24 9.7 1.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3904) FH2 PF02181.18 EFE44393.1 - 0.29 9.9 5.3 1.6 7.5 0.1 2.2 2 0 0 2 2 2 0 Formin Homology 2 Domain Tweety PF04906.8 EFE44393.1 - 0.3 9.4 3.9 0.16 10.3 0.9 1.8 2 0 0 2 2 2 0 Tweety DUF805 PF05656.9 EFE44393.1 - 0.36 10.6 1.8 0.6 9.9 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) MitMem_reg PF13012.1 EFE44393.1 - 0.44 10.6 4.6 3.2 7.8 2.1 2.5 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function XH PF03469.9 EFE44393.1 - 0.5 10.0 3.7 0.72 9.5 1.3 2.1 2 1 0 2 2 2 0 XH domain DUF607 PF04678.8 EFE44393.1 - 0.66 9.8 7.1 8.2 6.3 4.9 2.4 1 1 0 1 1 1 0 Protein of unknown function, DUF607 SP_C-Propep PF08999.5 EFE44393.1 - 0.85 9.1 4.6 1.5 8.3 3.2 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide 7tm_7 PF08395.7 EFE44393.1 - 2 7.3 9.2 0.79 8.6 0.4 2.7 3 0 0 3 3 3 0 7tm Chemosensory receptor NPV_P10 PF05531.7 EFE44393.1 - 2.2 8.5 5.6 29 4.9 0.2 3.5 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 EFE44393.1 - 2.4 8.2 13.2 6.7 6.8 0.6 3.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family HisKA_3 PF07730.8 EFE44393.1 - 3.8 7.9 10.4 2.8 8.3 0.1 4.2 3 2 3 6 6 5 0 Histidine kinase FliT PF05400.8 EFE44393.1 - 6.9 7.1 15.3 1.2 9.5 3.1 3.0 2 1 1 3 3 3 0 Flagellar protein FliT TMPIT PF07851.8 EFE44393.1 - 9.3 5.2 9.9 4.3 6.2 0.3 2.4 1 1 1 2 2 2 0 TMPIT-like protein AMP-binding PF00501.23 EFE44394.1 - 2.4e-57 194.2 0.0 3.1e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE44394.1 - 1.8e-11 44.8 0.0 3.1e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain IF4E PF01652.13 EFE44395.1 - 2.7e-57 192.8 1.8 3.3e-57 192.5 1.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Mpv17_PMP22 PF04117.7 EFE44396.1 - 2.8e-18 65.3 3.6 5.9e-16 57.8 0.1 2.4 2 0 0 2 2 2 2 Mpv17 / PMP22 family Ribosomal_S5 PF00333.15 EFE44397.1 - 6.8e-29 99.4 3.5 2.4e-28 97.6 1.4 2.4 3 0 0 3 3 3 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 EFE44397.1 - 6.8e-21 73.3 0.0 1.2e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DUF4263 PF14082.1 EFE44397.1 - 0.16 11.9 0.2 7 6.5 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4263) Bac_rhodopsin PF01036.13 EFE44399.1 - 5.2e-30 104.4 7.8 5.7e-30 104.2 5.4 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Glycos_transf_4 PF00953.16 EFE44399.1 - 0.0016 18.2 0.3 0.0016 18.2 0.2 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF1212 PF06738.7 EFE44399.1 - 0.054 12.9 2.3 0.1 12.0 1.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1212) DUF3671 PF12420.3 EFE44399.1 - 0.32 10.9 2.4 2.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function FtsX PF02687.16 EFE44399.1 - 0.47 10.2 11.7 0.21 11.3 0.4 2.2 2 0 0 2 2 2 0 FtsX-like permease family NfeD PF01957.13 EFE44399.1 - 2.1 8.4 6.6 8.7 6.4 3.5 2.2 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding HXXEE PF13787.1 EFE44399.1 - 8 6.8 10.0 5.3 7.4 0.5 2.5 1 1 1 2 2 2 0 Protein of unknown function with HXXEE motif tRNA-synt_1 PF00133.17 EFE44400.1 - 3.7e-163 543.7 0.0 4.9e-163 543.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EFE44400.1 - 2.8e-22 79.1 0.6 5.8e-22 78.0 0.4 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EFE44400.1 - 4.7e-21 74.8 0.1 2.4e-12 46.2 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.9 EFE44400.1 - 0.0018 17.8 3.3 0.0037 16.8 2.3 1.6 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS tRNA-synt_1e PF01406.14 EFE44400.1 - 0.075 12.1 0.0 3.4 6.7 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain UPF0183 PF03676.9 EFE44401.1 - 1.4e-46 158.8 0.0 3.2e-32 111.5 0.0 3.9 3 1 0 3 3 3 3 Uncharacterised protein family (UPF0183) Kinesin PF00225.18 EFE44402.1 - 1.1e-106 356.3 0.2 2.9e-106 354.9 0.2 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bind PF13931.1 EFE44402.1 - 3.2e-06 27.3 0.7 3.2e-06 27.3 0.5 4.9 4 1 1 5 5 5 1 Kinesin-associated microtubule-binding Baculo_PEP_C PF04513.7 EFE44402.1 - 0.17 11.7 0.1 0.17 11.7 0.1 4.8 3 3 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rhodanese PF00581.15 EFE44404.1 - 1.1e-22 80.5 0.0 3.6e-11 43.3 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain PIN_4 PF13638.1 EFE44405.1 - 0.00036 20.6 0.0 0.3 11.2 0.0 2.5 2 1 0 2 2 2 2 PIN domain NYN_YacP PF05991.6 EFE44405.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 YacP-like NYN domain DUF2335 PF10097.4 EFE44406.1 - 0.19 11.3 0.0 0.19 11.3 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2335) DUF2007 PF09413.5 EFE44407.1 - 0.0052 16.5 0.0 0.25 11.1 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF2007) NTP_transf_5 PF14907.1 EFE44407.1 - 0.041 13.2 0.0 0.046 13.0 0.0 1.3 1 1 0 1 1 1 0 Uncharacterised nucleotidyltransferase Metallophos_2 PF12850.2 EFE44408.1 - 1.6e-05 24.7 0.5 5.2e-05 23.1 0.4 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EFE44408.1 - 0.0019 17.6 7.7 0.01 15.2 5.3 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1814 PF08843.6 EFE44409.1 - 0.0017 18.2 0.0 0.0036 17.1 0.0 1.7 1 1 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF1814) RPEL PF02755.10 EFE44410.1 - 1.2e-24 84.9 2.8 1.9e-07 30.1 0.1 3.4 3 0 0 3 3 3 3 RPEL repeat Rotamase_3 PF13616.1 EFE44410.1 - 0.033 14.4 0.7 0.083 13.1 0.2 1.7 1 1 1 2 2 2 0 PPIC-type PPIASE domain Translin PF01997.11 EFE44411.1 - 4.7e-63 212.4 0.3 5.5e-63 212.1 0.2 1.0 1 0 0 1 1 1 1 Translin family LRR_adjacent PF08191.6 EFE44411.1 - 0.12 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 LRR adjacent Mannosyl_trans PF05007.8 EFE44412.1 - 5.3e-69 232.7 9.9 5.3e-69 232.7 6.9 1.6 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 EFE44412.1 - 5.7e-14 51.7 1.3 5.7e-14 51.7 0.9 2.0 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 EFE44412.1 - 3e-07 30.2 1.7 3e-07 30.2 1.2 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF2029) F-box-like PF12937.2 EFE44413.1 - 0.002 17.7 0.0 0.007 16.0 0.0 2.0 1 1 0 1 1 1 1 F-box-like Fungal_trans PF04082.13 EFE44414.1 - 4.2e-14 52.0 0.0 6.8e-14 51.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain SQS_PSY PF00494.14 EFE44415.1 - 6.1e-40 137.1 0.0 2.1e-39 135.4 0.0 1.7 2 0 0 2 2 2 1 Squalene/phytoene synthase Protocadherin PF08374.6 EFE44416.1 - 0.029 14.0 1.8 0.035 13.7 1.2 1.1 1 0 0 1 1 1 0 Protocadherin DUF3800 PF12686.2 EFE44416.1 - 0.1 12.2 0.1 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) FLO_LFY PF01698.11 EFE44416.1 - 1.6 7.4 6.6 2.4 6.8 4.5 1.3 1 1 0 1 1 1 0 Floricaula / Leafy protein Amidohydro_2 PF04909.9 EFE44417.1 - 3.3e-10 39.9 0.3 1.1e-09 38.2 0.2 2.0 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EFE44417.1 - 1.5e-07 31.4 0.3 2.8e-07 30.5 0.2 1.3 1 0 0 1 1 1 1 Amidohydrolase family CoA_binding_2 PF13380.1 EFE44417.1 - 0.0083 16.2 0.2 0.043 13.9 0.1 2.2 2 1 1 3 3 3 1 CoA binding domain DnaJ-X PF14308.1 EFE44418.1 - 1.6e-74 249.6 5.4 1.6e-74 249.6 3.7 3.0 4 0 0 4 4 4 1 X-domain of DnaJ-containing DnaJ PF00226.26 EFE44418.1 - 6.8e-26 89.7 0.3 1.9e-25 88.3 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain Iron_permease PF04120.7 EFE44419.1 - 8.8 5.9 5.6 0.58 9.7 0.3 1.6 2 0 0 2 2 2 0 Low affinity iron permease IMS PF00817.15 EFE44420.1 - 1.8e-41 141.4 1.2 2.9e-41 140.7 0.3 1.9 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.3 EFE44420.1 - 3.4e-13 49.6 0.5 7.2e-13 48.5 0.1 1.7 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 EFE44420.1 - 3.5e-05 23.5 0.0 9.7e-05 22.2 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Moricin PF06451.6 EFE44420.1 - 0.0089 15.5 0.4 3.1 7.3 0.0 3.0 3 0 0 3 3 3 2 Moricin Acetyltransf_10 PF13673.1 EFE44422.1 - 4.5e-07 30.0 0.1 1.1e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE44422.1 - 2.2e-05 24.3 1.2 3e-05 23.9 0.1 1.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFE44422.1 - 4.3e-05 23.5 0.0 9.9e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFE44422.1 - 0.0072 16.1 0.0 0.11 12.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Ferritin_2 PF13668.1 EFE44423.1 - 1.2e-13 51.2 0.2 2.1e-13 50.3 0.2 1.3 1 0 0 1 1 1 1 Ferritin-like domain Sugar_tr PF00083.19 EFE44424.1 - 8e-19 67.5 23.7 8.9e-11 41.0 5.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2838 PF10998.3 EFE44424.1 - 6.7 6.6 9.9 0.53 10.1 2.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2838) Pkinase PF00069.20 EFE44425.1 - 4.3e-31 108.0 0.0 6.1e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44425.1 - 2.7e-11 43.0 0.0 3.6e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.17 EFE44425.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 RIO1 family AMP-binding PF00501.23 EFE44426.1 - 1.2e-75 254.5 0.1 1.4e-75 254.2 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFE44426.1 - 9.7e-11 42.4 0.5 2e-10 41.4 0.3 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.11 EFE44427.1 - 2e-39 135.2 26.7 2e-39 135.2 18.5 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sensor PF13796.1 EFE44427.1 - 0.00011 21.9 6.5 0.00011 21.9 4.5 3.8 2 1 1 3 3 3 1 Putative sensor MerE PF05052.7 EFE44427.1 - 0.013 15.4 2.9 0.054 13.4 2.0 2.1 1 0 0 1 1 1 0 MerE protein Vac7 PF12751.2 EFE44429.1 - 1.7e-147 491.3 2.8 1.7e-147 491.3 2.0 2.6 3 1 1 4 4 4 1 Vacuolar segregation subunit 7 CorA PF01544.13 EFE44430.1 - 4.9e-38 130.8 1.5 1.6e-37 129.1 1.0 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein CHD5 PF04420.9 EFE44431.1 - 5.1 6.7 0.5 23 4.5 0.3 2.1 1 0 0 1 1 1 0 CHD5-like protein Halogen_Hydrol PF10112.4 EFE44431.1 - 6.1 6.1 3.4 2.7 7.3 0.1 2.1 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein adh_short PF00106.20 EFE44432.1 - 1e-23 84.1 2.1 8.1e-23 81.1 2.2 2.0 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFE44432.1 - 1.2e-10 41.4 3.3 1.6e-08 34.4 3.0 3.0 1 1 1 2 2 2 1 KR domain adh_short_C2 PF13561.1 EFE44432.1 - 6.6e-10 39.1 0.0 9.6e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFE44432.1 - 3.9e-06 26.9 0.0 1.2e-05 25.4 0.0 2.0 2 1 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 EFE44432.1 - 0.0021 17.5 0.0 0.0062 15.9 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EFE44432.1 - 0.006 15.5 0.0 0.01 14.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain UPF0146 PF03686.8 EFE44432.1 - 0.039 13.7 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) 3Beta_HSD PF01073.14 EFE44432.1 - 0.12 11.0 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ribosomal_L19e PF01280.15 EFE44437.1 - 2e-61 206.1 8.6 2e-61 206.1 6.0 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e RNase_H2-Ydr279 PF09468.5 EFE44437.1 - 0.031 13.4 1.0 0.032 13.4 0.7 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF4239 PF14023.1 EFE44437.1 - 0.049 12.9 2.0 0.077 12.3 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) DUF3554 PF12074.3 EFE44438.1 - 8.1e-71 239.1 2.8 3e-70 237.3 0.4 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3554) HEAT PF02985.17 EFE44438.1 - 4.6e-32 107.1 37.5 0.052 13.6 0.0 22.4 24 0 0 24 24 24 7 HEAT repeat HEAT_2 PF13646.1 EFE44438.1 - 1.2e-29 102.4 50.2 1.6e-10 41.1 0.0 15.6 10 3 6 17 17 17 7 HEAT repeats HEAT_EZ PF13513.1 EFE44438.1 - 2.6e-22 78.6 56.0 6.7e-06 26.4 0.0 22.6 20 7 8 28 28 26 6 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFE44438.1 - 2e-12 47.3 0.0 1.5 9.2 0.0 8.4 6 1 2 8 8 8 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 EFE44438.1 - 1.1e-08 35.1 1.2 0.6 9.9 0.0 8.1 8 1 1 10 10 10 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 EFE44438.1 - 1.7e-07 30.8 0.0 2.5 7.3 0.0 6.8 5 1 2 7 7 7 3 CLASP N terminal ParcG PF10274.4 EFE44438.1 - 5.2e-07 29.7 6.4 0.15 11.9 0.0 6.7 6 0 0 6 6 6 2 Parkin co-regulated protein UME PF08064.8 EFE44438.1 - 9.2e-07 28.7 0.3 4.6 7.2 0.0 7.1 6 2 2 8 8 8 2 UME (NUC010) domain FANCI_S2 PF14676.1 EFE44438.1 - 0.0011 18.9 0.6 3.3 7.5 0.0 4.3 3 0 0 3 3 3 1 FANCI solenoid 2 DUF3535 PF12054.3 EFE44438.1 - 0.0039 15.8 0.0 0.012 14.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3535) HA2 PF04408.18 EFE44439.1 - 6.3e-18 64.6 0.0 1.6e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE44439.1 - 9.4e-12 44.6 0.1 2.4e-11 43.3 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFE44439.1 - 9.8e-10 38.1 0.0 2.4e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFE44439.1 - 4.8e-09 36.4 0.1 6.9e-07 29.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 EFE44439.1 - 0.0016 17.4 0.0 0.003 16.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 EFE44439.1 - 0.0042 16.5 0.0 0.0094 15.4 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_29 PF13555.1 EFE44439.1 - 0.01 15.3 0.0 0.025 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 EFE44439.1 - 0.019 15.2 0.2 0.19 12.0 0.0 2.7 2 0 0 2 2 2 0 ABC transporter KaiC PF06745.8 EFE44439.1 - 0.023 13.8 0.1 0.14 11.2 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_23 PF13476.1 EFE44439.1 - 0.029 14.7 0.0 0.029 14.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.17 EFE44439.1 - 0.045 12.6 0.1 0.11 11.2 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain Spt5_N PF11942.3 EFE44441.1 - 0.53 10.9 7.0 0.71 10.5 4.9 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Vfa1 PF08432.5 EFE44442.1 - 0.00018 21.5 3.5 0.00026 21.0 2.4 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF4557 PF15101.1 EFE44442.1 - 1.1 9.0 4.7 1.7 8.4 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) RR_TM4-6 PF06459.7 EFE44442.1 - 1.2 8.9 8.4 1.7 8.4 5.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 N-SET PF11764.3 EFE44443.1 - 6.6e-48 162.7 0.5 3.1e-47 160.5 0.3 2.3 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.3 EFE44443.1 - 1.3e-25 88.4 0.3 2.5e-25 87.5 0.2 1.5 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.23 EFE44443.1 - 1.6e-23 83.8 0.3 1.6e-23 83.8 0.2 3.3 3 1 0 3 3 3 1 SET domain RRM_1 PF00076.17 EFE44443.1 - 0.00016 21.2 0.0 0.00034 20.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFE44443.1 - 0.19 11.5 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Trm112p PF03966.11 EFE44444.1 - 6.7e-14 51.9 0.1 8.5e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein TF_Zn_Ribbon PF08271.7 EFE44444.1 - 0.7 9.2 2.9 0.39 10.0 0.3 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding Rad60-SLD PF11976.3 EFE44445.1 - 3.2e-24 84.4 1.5 1.3e-19 69.6 0.8 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EFE44445.1 - 0.00041 19.6 0.4 0.02 14.3 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin family SPT2 PF08243.6 EFE44445.1 - 6.6 7.0 18.1 0.07 13.4 4.8 3.1 3 0 0 3 3 3 0 SPT2 chromatin protein LSM PF01423.17 EFE44446.1 - 2.2e-15 55.9 0.0 2.8e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EFE44446.1 - 0.0063 16.4 0.1 0.0077 16.1 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF1106 PF06523.6 EFE44446.1 - 0.15 11.9 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) SPAN PF02510.9 EFE44446.1 - 0.15 11.0 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Surface presentation of antigens protein IF-2B PF01008.12 EFE44447.1 - 1.1e-69 234.5 0.7 1.4e-69 234.2 0.5 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family SbmA_BacA PF05992.7 EFE44447.1 - 0.014 14.6 0.1 0.029 13.5 0.0 1.5 2 0 0 2 2 2 0 SbmA/BacA-like family Pkinase PF00069.20 EFE44448.1 - 7.1e-13 48.3 0.0 2.2e-12 46.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44448.1 - 2.1e-10 40.1 0.0 5e-10 38.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44448.1 - 4.7e-05 22.4 0.0 6.5e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like GST_C PF00043.20 EFE44449.1 - 1.1e-14 54.1 0.0 2.1e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFE44449.1 - 1.2e-12 47.9 0.0 1.8e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFE44449.1 - 3.1e-10 40.0 0.0 5e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE44449.1 - 3.7e-09 36.4 0.0 1.3e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFE44449.1 - 1.8e-08 34.1 0.1 3.4e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFE44449.1 - 7.5e-06 26.3 0.4 1.1e-05 25.8 0.3 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.5 EFE44449.1 - 0.024 14.9 0.0 0.053 13.9 0.0 1.6 1 1 0 1 1 1 0 MetRS-N binding domain Adaptin_N PF01602.15 EFE44450.1 - 7.3e-75 252.2 0.0 1.5e-74 251.2 0.0 1.5 1 1 0 1 1 1 1 Adaptin N terminal region HEAT PF02985.17 EFE44450.1 - 0.011 15.7 0.3 21 5.5 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat Cnd1 PF12717.2 EFE44450.1 - 0.1 12.4 2.4 0.6 9.9 0.1 2.5 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF4604 PF15377.1 EFE44450.1 - 5.6 7.1 22.8 2.8 8.1 13.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) TPR_14 PF13428.1 EFE44451.1 - 4.3e-08 33.0 0.5 0.051 14.2 0.0 4.6 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFE44451.1 - 1.6e-07 30.8 1.1 0.00015 21.3 0.1 4.0 2 1 3 5 5 5 2 TPR repeat TPR_19 PF14559.1 EFE44451.1 - 1.9e-07 31.2 0.1 0.21 11.9 0.0 4.3 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFE44451.1 - 2.2e-05 24.3 0.0 0.094 12.9 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFE44451.1 - 3.4e-05 23.4 0.0 0.027 14.3 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFE44451.1 - 0.00016 21.2 0.0 0.017 14.8 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE44451.1 - 0.0011 19.6 1.7 2.3 8.9 0.0 4.3 2 1 3 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFE44451.1 - 0.0049 16.7 1.2 3.2 7.7 0.0 3.5 2 2 1 4 4 4 2 Tetratricopeptide repeat PPR_3 PF13812.1 EFE44451.1 - 0.019 15.2 0.0 0.32 11.3 0.0 2.7 3 0 0 3 3 2 0 Pentatricopeptide repeat domain BTAD PF03704.12 EFE44451.1 - 0.035 14.4 0.0 12 6.2 0.0 2.7 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_6 PF13174.1 EFE44451.1 - 0.059 13.8 0.0 55 4.5 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFE44451.1 - 0.073 12.7 0.1 0.41 10.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Nucleoplasmin PF03066.10 EFE44453.1 - 0.011 15.2 4.8 0.029 13.8 3.3 1.6 1 0 0 1 1 1 0 Nucleoplasmin Borrelia_P83 PF05262.6 EFE44453.1 - 0.8 7.8 21.1 1.2 7.3 14.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Uteroglobin PF01099.12 EFE44454.1 - 0.057 13.2 0.2 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Uteroglobin family Bravo_FIGEY PF13882.1 EFE44454.1 - 0.16 12.9 1.5 0.24 12.3 1.0 1.3 1 0 0 1 1 1 0 Bravo-like intracellular region Kinesin PF00225.18 EFE44455.1 - 5.3e-97 324.5 0.1 1e-96 323.5 0.1 1.5 1 0 0 1 1 1 1 Kinesin motor domain MoCF_biosynth PF00994.19 EFE44455.1 - 0.048 13.0 0.0 0.36 10.2 0.0 2.5 3 0 0 3 3 3 0 Probable molybdopterin binding domain DUF3899 PF13038.1 EFE44455.1 - 0.38 10.9 1.4 0.5 10.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Ank_2 PF12796.2 EFE44456.1 - 3.2e-117 383.1 17.4 5e-22 78.0 0.1 5.8 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 EFE44456.1 - 2.5e-74 241.6 13.1 1.9e-08 33.6 0.0 12.3 12 0 0 12 12 12 11 Ankyrin repeat Ank_4 PF13637.1 EFE44456.1 - 2.2e-61 203.1 1.7 1.1e-12 48.1 0.1 8.3 4 3 5 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE44456.1 - 3.3e-56 181.5 9.8 3.8e-06 26.6 0.0 12.2 12 0 0 12 12 12 11 Ankyrin repeat Ank_5 PF13857.1 EFE44456.1 - 4.5e-54 179.2 18.1 1.5e-10 40.9 0.0 8.5 1 1 10 11 11 11 10 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 EFE44456.1 - 0.0011 18.5 0.6 27 4.1 0.0 5.3 3 2 3 6 6 6 0 Shigella flexneri OspC protein F-box-like PF12937.2 EFE44456.1 - 0.022 14.4 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 F-box-like NOGCT PF08155.6 EFE44457.1 - 0.0033 17.0 0.3 0.0081 15.8 0.2 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain DAGAT PF03982.8 EFE44458.1 - 1.5e-91 306.2 0.0 1.7e-91 306.0 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Rer1 PF03248.8 EFE44458.1 - 0.78 9.2 3.1 1.6 8.2 2.1 1.5 1 0 0 1 1 1 0 Rer1 family MIP-T3 PF10243.4 EFE44460.1 - 0.026 13.0 45.9 0.033 12.6 31.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Asp-B-Hydro_N PF05279.6 EFE44460.1 - 0.39 10.5 26.7 0.51 10.1 18.5 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CRT10 PF08728.5 EFE44460.1 - 1.4 6.8 9.7 1.5 6.7 6.7 1.0 1 0 0 1 1 1 0 CRT10 AvrE PF11725.3 EFE44460.1 - 1.7 5.5 18.7 1.9 5.4 13.0 1.0 1 0 0 1 1 1 0 Pathogenicity factor CDC27 PF09507.5 EFE44460.1 - 1.9 7.6 42.6 3.1 6.9 29.5 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pneumovirus_M2 PF06436.6 EFE44461.1 - 0.013 14.7 1.6 0.017 14.3 1.1 1.3 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) DUF4473 PF14747.1 EFE44461.1 - 0.21 11.8 3.3 0.22 11.7 0.4 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4473) DUF2852 PF11014.3 EFE44461.1 - 0.94 9.4 5.5 0.29 11.0 1.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) RRF PF01765.14 EFE44461.1 - 3.5 7.0 12.1 3.7 6.9 0.3 2.1 1 1 1 2 2 2 0 Ribosome recycling factor Syja_N PF02383.13 EFE44462.1 - 2.3e-79 266.4 0.0 3.2e-79 265.9 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 EFE44462.1 - 7.1e-26 91.6 0.2 1.9e-25 90.2 0.0 1.8 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.20 EFE44463.1 - 4e-63 212.9 0.0 4.8e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44463.1 - 7.6e-35 120.2 0.0 1.1e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44463.1 - 0.099 11.5 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like IGR PF09597.5 EFE44464.1 - 2e-19 69.2 0.8 3.8e-19 68.3 0.6 1.5 1 0 0 1 1 1 1 IGR protein motif p450 PF00067.17 EFE44465.1 - 3.7e-70 236.7 0.0 4.8e-70 236.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 K-box PF01486.12 EFE44465.1 - 0.091 12.5 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 K-box region Pkinase PF00069.20 EFE44466.1 - 2.8e-60 203.6 0.1 3.4e-58 196.8 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44466.1 - 3.6e-30 104.8 0.3 4.1e-28 98.1 0.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 EFE44466.1 - 8.9e-16 57.7 0.2 2.6e-15 56.2 0.1 1.9 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.1 EFE44466.1 - 0.00017 20.6 1.4 0.42 9.5 0.0 2.7 2 1 1 3 3 3 2 Kinase-like Pox_ser-thr_kin PF05445.6 EFE44466.1 - 0.0086 14.9 0.1 0.013 14.3 0.1 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kdo PF06293.9 EFE44466.1 - 0.029 13.4 0.0 0.05 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PI3_PI4_kinase PF00454.22 EFE44467.1 - 1.5e-35 122.7 0.0 1e-34 120.0 0.0 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 EFE44467.1 - 1.4e-23 83.0 0.0 3.2e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Pkinase PF00069.20 EFE44468.1 - 2.2e-08 33.5 0.0 5.7e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain ArfGap PF01412.13 EFE44471.1 - 8e-33 112.7 2.6 1e-32 112.3 0.0 2.3 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.24 EFE44471.1 - 3e-09 37.0 0.1 9.5e-09 35.4 0.1 1.9 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.2 EFE44471.1 - 0.05 13.9 0.0 0.32 11.3 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) bact-PGI_C PF10432.4 EFE44471.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal region Ank_4 PF13637.1 EFE44471.1 - 0.2 12.2 0.7 0.72 10.4 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Chromo PF00385.19 EFE44472.1 - 7.1e-05 22.3 0.6 7.1e-05 22.3 0.4 2.0 1 1 1 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Ank_2 PF12796.2 EFE44473.1 - 5.7e-80 263.7 6.0 9.2e-16 57.9 0.0 7.0 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.25 EFE44473.1 - 1.4e-51 169.8 12.4 4.7e-09 35.6 0.0 11.7 11 0 0 11 11 11 10 Ankyrin repeat Ank_4 PF13637.1 EFE44473.1 - 4.1e-50 167.3 6.3 2.7e-09 37.2 0.6 10.9 3 1 9 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE44473.1 - 1.4e-40 133.2 4.0 3.1e-05 23.7 0.0 13.1 13 1 0 13 13 13 8 Ankyrin repeat Ank_5 PF13857.1 EFE44473.1 - 4.5e-37 125.2 12.2 6e-07 29.5 0.0 9.0 5 2 6 11 11 11 8 Ankyrin repeats (many copies) gag-asp_proteas PF13975.1 EFE44473.1 - 0.03 14.1 0.1 3.4 7.5 0.0 3.5 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 EFE44473.1 - 0.031 14.7 0.3 10 6.6 0.0 4.3 4 1 0 4 4 4 0 Aspartyl protease RVP PF00077.15 EFE44473.1 - 0.036 13.9 0.1 17 5.4 0.0 3.8 3 1 1 4 4 4 0 Retroviral aspartyl protease Fungal_trans_2 PF11951.3 EFE44475.1 - 4.9e-26 91.2 0.5 1.2e-25 89.9 0.3 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE44475.1 - 7e-09 35.4 9.0 1.2e-08 34.7 6.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease PF00324.16 EFE44476.1 - 6.9e-138 459.9 37.0 8.5e-138 459.6 25.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFE44476.1 - 3e-34 118.3 37.0 4e-34 117.8 25.7 1.1 1 0 0 1 1 1 1 Amino acid permease APH PF01636.18 EFE44477.1 - 1.9e-09 37.6 0.1 1.2e-06 28.4 0.0 2.9 4 0 0 4 4 4 2 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE44477.1 - 0.00015 20.5 0.1 0.23 10.0 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.9 EFE44477.1 - 0.021 13.7 0.0 1.4 7.8 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase EcKinase PF02958.15 EFE44477.1 - 0.032 13.3 0.0 0.071 12.2 0.0 1.5 2 0 0 2 2 2 0 Ecdysteroid kinase Mac PF12464.3 EFE44478.1 - 0.037 14.0 0.1 0.064 13.2 0.1 1.3 1 0 0 1 1 1 0 Maltose acetyltransferase PLC-beta_C PF08703.5 EFE44478.1 - 0.069 12.8 0.6 0.094 12.4 0.4 1.2 1 0 0 1 1 1 0 PLC-beta C terminal FCH PF00611.18 EFE44479.1 - 5.8e-14 52.0 0.2 3e-13 49.7 0.0 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.22 EFE44479.1 - 6.1e-14 51.8 0.2 2.5e-13 49.9 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.16 EFE44479.1 - 2.3e-08 33.6 0.0 4.6e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) TIP120 PF08623.5 EFE44479.1 - 0.0041 16.7 0.3 0.47 10.0 0.0 2.6 2 0 0 2 2 2 2 TATA-binding protein interacting (TIP20) RTA1 PF04479.8 EFE44480.1 - 9e-07 28.5 4.0 2.9e-06 26.9 2.9 1.7 1 1 0 1 1 1 1 RTA1 like protein Asp-Al_Ex PF06826.7 EFE44480.1 - 0.015 14.8 0.4 0.029 13.8 0.3 1.5 1 0 0 1 1 1 0 Predicted Permease Membrane Region AAA_16 PF13191.1 EFE44481.1 - 2.5e-16 60.1 0.3 1.6e-14 54.2 0.0 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 EFE44481.1 - 4.4e-14 52.8 0.0 1e-13 51.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE44481.1 - 4.4e-14 52.7 0.0 1.3e-13 51.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain Cdc6_C PF09079.6 EFE44481.1 - 2.4e-07 30.3 0.0 6.1e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 CDC6, C terminal TIP49 PF06068.8 EFE44481.1 - 0.00018 20.3 0.0 0.00028 19.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus NTPase_1 PF03266.10 EFE44481.1 - 0.00047 19.9 0.0 0.00089 19.0 0.0 1.5 1 0 0 1 1 1 1 NTPase NB-ARC PF00931.17 EFE44481.1 - 0.0007 18.5 0.0 0.002 17.0 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain Arch_ATPase PF01637.13 EFE44481.1 - 0.00079 19.1 0.0 0.0016 18.1 0.0 1.5 1 1 0 1 1 1 1 Archaeal ATPase PIF1 PF05970.9 EFE44481.1 - 0.0017 17.4 0.0 0.0029 16.6 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_5 PF07728.9 EFE44481.1 - 0.0032 17.2 0.0 0.0072 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) T2SE PF00437.15 EFE44481.1 - 0.0035 16.2 0.0 0.0069 15.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.1 EFE44481.1 - 0.0046 16.8 0.0 0.012 15.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.1 EFE44481.1 - 0.0051 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 EFE44481.1 - 0.0052 17.0 0.0 0.009 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EFE44481.1 - 0.0078 16.3 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_17 PF13207.1 EFE44481.1 - 0.0083 16.9 0.0 0.015 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFE44481.1 - 0.0083 15.1 0.0 0.019 13.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus ABC_tran PF00005.22 EFE44481.1 - 0.013 15.7 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.1 EFE44481.1 - 0.027 14.4 0.0 0.079 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA12 PF10443.4 EFE44481.1 - 0.032 12.7 0.0 0.047 12.1 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein DUF2075 PF09848.4 EFE44481.1 - 0.049 12.6 0.0 0.076 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 EFE44481.1 - 0.049 13.2 0.1 0.17 11.5 0.0 1.9 1 1 0 1 1 1 0 NACHT domain KAP_NTPase PF07693.9 EFE44481.1 - 0.061 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_30 PF13604.1 EFE44481.1 - 0.095 12.2 0.0 0.23 10.9 0.0 1.6 2 0 0 2 2 1 0 AAA domain Herpes_US12 PF05363.7 EFE44481.1 - 0.73 10.3 4.4 22 5.6 0.1 3.4 3 0 0 3 3 3 0 Herpesvirus US12 family UBA_4 PF14555.1 EFE44482.1 - 6.9e-14 51.1 0.1 1.3e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.1 EFE44482.1 - 1.3e-12 47.5 0.0 2.6e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.15 EFE44482.1 - 2e-08 34.1 0.0 1.6e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 UBX domain Pkinase PF00069.20 EFE44484.1 - 3.2e-62 210.0 0.0 4.9e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44484.1 - 3.8e-46 157.2 0.0 5.9e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44484.1 - 0.012 14.6 0.0 0.023 13.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like COesterase PF00135.23 EFE44485.1 - 9.8e-62 209.3 0.0 1.4e-61 208.8 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFE44485.1 - 2e-09 37.3 0.0 3e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFE44485.1 - 0.099 12.3 0.0 0.22 11.2 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Fungal_trans PF04082.13 EFE44486.1 - 1.1e-18 67.0 0.0 4.3e-11 42.1 0.0 2.2 1 1 1 2 2 2 2 Fungal specific transcription factor domain MR_MLE_C PF13378.1 EFE44487.1 - 1.6e-21 76.3 0.0 2.9e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE PF01188.16 EFE44487.1 - 1e-10 41.9 0.0 2.1e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 EFE44487.1 - 0.0032 17.4 0.2 0.011 15.7 0.0 1.8 1 1 1 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Beta-lactamase PF00144.19 EFE44488.1 - 3.7e-28 98.5 0.0 6.6e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase adh_short PF00106.20 EFE44489.1 - 2.9e-16 59.8 0.0 4e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE44489.1 - 1.5e-15 57.6 0.0 2e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE44489.1 - 0.0046 16.6 0.0 0.0068 16.0 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF3431 PF11913.3 EFE44490.1 - 3.4e-83 278.5 0.1 4.2e-83 278.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Amidohydro_2 PF04909.9 EFE44493.1 - 5.9e-11 42.4 0.0 8e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase Spt5-NGN PF03439.8 EFE44493.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section ADH_zinc_N PF00107.21 EFE44494.1 - 1.9e-24 85.6 0.4 3.1e-24 84.9 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE44494.1 - 3.5e-17 62.1 0.8 8.7e-17 60.8 0.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain CmcI PF04989.7 EFE44494.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Cephalosporin hydroxylase CENP-B_dimeris PF09026.5 EFE44495.1 - 1.7 8.8 9.1 1.4 9.2 4.6 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TPR_11 PF13414.1 EFE44496.1 - 8.9e-07 28.4 0.4 2e-06 27.3 0.2 1.5 1 0 0 1 1 1 1 TPR repeat SET PF00856.23 EFE44496.1 - 3.3e-06 27.5 5.8 7.5e-06 26.3 0.2 3.3 3 1 0 3 3 3 1 SET domain TPR_9 PF13371.1 EFE44496.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFE44496.1 - 0.0042 17.7 0.1 0.01 16.4 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFE44496.1 - 0.014 14.9 0.1 0.11 12.1 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat SAP PF02037.22 EFE44496.1 - 0.14 11.7 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 SAP domain Allexi_40kDa PF05549.6 EFE44497.1 - 0.037 13.3 0.0 0.037 13.3 0.0 3.5 3 0 0 3 3 3 0 Allexivirus 40kDa protein zf-H2C2_2 PF13465.1 EFE44499.1 - 1.1e-12 47.5 15.7 5.3e-06 26.4 1.1 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EFE44499.1 - 1.9e-09 37.2 23.1 0.012 15.8 4.5 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE44499.1 - 3e-06 27.1 21.9 0.0086 16.3 4.3 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE44499.1 - 0.0044 17.1 10.0 0.52 10.5 1.9 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 EFE44499.1 - 0.045 13.8 6.3 0.092 12.8 4.3 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.6 EFE44499.1 - 0.14 11.8 6.9 2.8 7.5 1.1 2.9 1 1 1 2 2 2 0 GAGA factor zf-C2H2_6 PF13912.1 EFE44499.1 - 0.34 10.8 13.9 0.38 10.7 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DZR PF12773.2 EFE44499.1 - 1.1 9.1 5.3 10 6.0 3.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.5 EFE44499.1 - 2.3 8.2 8.0 10 6.1 2.5 3.1 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_2 PF12756.2 EFE44499.1 - 3.2 7.9 11.2 3.1 7.9 1.2 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Stk19 PF10494.4 EFE44501.1 - 3.1e-59 200.3 0.0 4.6e-59 199.8 0.0 1.2 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 DUF3074 PF11274.3 EFE44501.1 - 1.4e-05 24.7 0.4 2.6e-05 23.9 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Glyco_transf_20 PF00982.16 EFE44502.1 - 1.1e-156 521.9 0.1 1.9e-156 521.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EFE44502.1 - 1.9e-35 121.8 0.0 5.1e-34 117.2 0.0 2.3 1 1 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.6 EFE44502.1 - 0.02 14.3 0.9 0.066 12.6 0.3 1.9 2 0 0 2 2 2 0 Starch synthase catalytic domain Sporozoite_P67 PF05642.6 EFE44502.1 - 1 7.1 8.4 1.7 6.3 5.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen 4HBT_3 PF13622.1 EFE44503.1 - 1.2e-53 182.4 0.0 1.4e-53 182.2 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.17 EFE44504.1 - 3.9e-06 26.8 0.0 6.4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.14 EFE44504.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 MaoC like domain DUF1690 PF07956.6 EFE44506.1 - 0.0036 17.2 2.1 0.0049 16.8 1.5 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) IFT57 PF10498.4 EFE44506.1 - 0.038 12.7 1.0 0.049 12.3 0.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Peptidase_C65 PF10275.4 EFE44506.1 - 0.069 12.4 0.4 0.094 12.0 0.2 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain PMC2NT PF08066.7 EFE44506.1 - 0.074 13.3 0.4 0.11 12.7 0.3 1.3 1 0 0 1 1 1 0 PMC2NT (NUC016) domain Med14 PF08638.6 EFE44506.1 - 0.074 12.2 0.2 0.09 12.0 0.2 1.3 1 1 0 1 1 1 0 Mediator complex subunit MED14 DUF883 PF05957.8 EFE44506.1 - 0.13 12.6 3.6 0.17 12.2 2.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) CCDC-167 PF15188.1 EFE44506.1 - 0.39 10.6 5.2 0.8 9.6 3.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 APG6 PF04111.7 EFE44506.1 - 0.72 8.8 5.0 0.95 8.4 3.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 bZIP_1 PF00170.16 EFE44507.1 - 2.1e-05 24.3 10.5 0.00015 21.6 7.4 2.0 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFE44507.1 - 5e-05 23.0 10.1 8.4e-05 22.3 7.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper DBP10CT PF08147.7 EFE44508.1 - 0.12 12.2 0.4 0.22 11.3 0.3 1.4 1 0 0 1 1 1 0 DBP10CT (NUC160) domain WD40 PF00400.27 EFE44509.1 - 6.2e-49 162.2 25.5 2.1e-12 46.4 0.0 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EFE44509.1 - 0.0007 19.0 0.0 0.49 9.9 0.0 3.7 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.9 EFE44509.1 - 0.1 11.3 0.3 0.18 10.5 0.2 1.3 1 0 0 1 1 1 0 Coatomer WD associated region Yae1_N PF09811.4 EFE44510.1 - 0.0016 17.9 0.9 0.0028 17.1 0.7 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal tRNA-synt_1g PF09334.6 EFE44511.1 - 3.7e-141 470.3 0.0 5.1e-141 469.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EFE44511.1 - 6.5e-09 34.3 0.0 4.2e-05 21.7 0.0 3.9 3 1 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) BRF1 PF07741.8 EFE44511.1 - 0.078 13.2 8.9 0.16 12.1 6.2 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Elongin_A PF06881.6 EFE44511.1 - 0.54 10.6 8.8 0.19 12.1 4.0 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A BLVR PF06375.6 EFE44511.1 - 1.9 8.3 10.0 3.2 7.5 6.9 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) WD40 PF00400.27 EFE44512.1 - 3.9e-27 93.1 4.7 2.9e-07 30.1 0.0 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat PXA PF02194.10 EFE44514.1 - 3.1e-47 160.5 0.2 1.1e-46 158.6 0.0 2.1 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.7 EFE44514.1 - 1.1e-26 93.1 0.0 3.5e-26 91.5 0.0 2.0 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.19 EFE44514.1 - 8.2e-20 70.6 0.1 3.5e-19 68.6 0.1 2.1 2 0 0 2 2 2 1 PX domain RGS PF00615.14 EFE44514.1 - 1.5e-10 41.1 0.0 3.8e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Tcp11 PF05794.8 EFE44515.1 - 6.6e-49 166.8 0.4 9.8e-48 162.9 0.3 2.1 1 1 0 1 1 1 1 T-complex protein 11 HMA PF00403.21 EFE44516.1 - 0.0003 20.8 0.2 0.00041 20.4 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain AHSP PF09236.5 EFE44516.1 - 0.0034 17.5 0.0 0.0041 17.3 0.0 1.1 1 0 0 1 1 1 1 Alpha-haemoglobin stabilising protein Moricin PF06451.6 EFE44516.1 - 0.17 11.4 0.6 0.24 10.9 0.4 1.2 1 0 0 1 1 1 0 Moricin MHYT PF03707.11 EFE44517.1 - 4.6e-08 33.0 18.1 9e-06 25.7 0.9 3.8 3 0 0 3 3 3 2 Bacterial signalling protein N terminal repeat PVL_ORF50 PF07768.6 EFE44518.1 - 2.5 8.1 6.8 3 7.8 4.7 1.1 1 0 0 1 1 1 0 PVL ORF-50-like family Menin PF05053.8 EFE44518.1 - 3.6 5.6 5.5 3.7 5.5 3.8 1.0 1 0 0 1 1 1 0 Menin DUF2293 PF10056.4 EFE44520.1 - 0.00075 19.4 0.0 0.0027 17.6 0.0 2.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) Rep_fac-A_C PF08646.5 EFE44521.1 - 5.3e-42 142.9 8.5 5.8e-40 136.3 4.1 2.3 2 0 0 2 2 2 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 EFE44521.1 - 5.8e-14 51.6 0.1 1.6e-08 34.2 0.0 3.8 3 1 1 4 4 4 3 OB-fold nucleic acid binding domain DUF223 PF02721.9 EFE44521.1 - 0.17 12.0 0.6 1.1 9.4 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF223 SNARE_assoc PF09335.6 EFE44522.1 - 0.043 14.0 0.3 6.4 6.9 0.0 2.2 2 0 0 2 2 2 0 SNARE associated Golgi protein La PF05383.12 EFE44523.1 - 1e-18 66.8 0.2 1.8e-18 66.0 0.2 1.4 1 0 0 1 1 1 1 La domain Ank_5 PF13857.1 EFE44524.1 - 4.5e-15 55.3 0.4 1.1e-11 44.6 0.4 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFE44524.1 - 1.9e-12 47.3 2.6 1.4e-06 28.4 0.2 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFE44524.1 - 1.5e-11 44.4 0.1 2.1e-08 34.4 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE44524.1 - 1.5e-06 27.8 0.1 0.0016 18.4 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.25 EFE44524.1 - 2.4e-06 27.0 0.2 0.00021 20.9 0.1 2.9 2 1 0 2 2 2 1 Ankyrin repeat YejG PF13989.1 EFE44524.1 - 0.039 14.0 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 YejG-like protein DUF619 PF04768.8 EFE44526.1 - 3.4e-50 169.7 0.1 7.2e-50 168.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Semialdhyde_dh PF01118.19 EFE44526.1 - 3.1e-30 104.9 0.0 1.2e-29 103.0 0.0 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.23 EFE44526.1 - 3.7e-24 85.5 0.0 6.7e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family DapB_N PF01113.15 EFE44526.1 - 0.11 12.4 0.0 0.34 10.8 0.0 2.0 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Synaptobrevin PF00957.16 EFE44527.1 - 8.1e-33 111.8 0.9 1e-32 111.5 0.6 1.0 1 0 0 1 1 1 1 Synaptobrevin Pox_Ag35 PF03286.9 EFE44528.1 - 0.0033 16.9 11.8 0.0033 16.9 8.2 1.1 1 0 0 1 1 1 1 Pox virus Ag35 surface protein Vfa1 PF08432.5 EFE44528.1 - 0.025 14.6 11.7 0.023 14.7 8.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 BUD22 PF09073.5 EFE44528.1 - 0.038 13.0 16.1 0.042 12.9 11.1 1.0 1 0 0 1 1 1 0 BUD22 Spore_coat_CotO PF14153.1 EFE44528.1 - 0.065 12.6 9.5 0.06 12.7 6.6 1.1 1 0 0 1 1 1 0 Spore coat protein CotO CPSF100_C PF13299.1 EFE44528.1 - 0.071 13.3 7.4 0.08 13.1 5.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FancD2 PF14631.1 EFE44528.1 - 0.074 10.1 6.3 0.086 9.9 4.4 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease FLO_LFY PF01698.11 EFE44528.1 - 0.095 11.5 13.7 0.11 11.3 9.5 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein CDC27 PF09507.5 EFE44528.1 - 0.11 11.7 13.3 0.11 11.6 9.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Myc_N PF01056.13 EFE44528.1 - 0.11 11.6 2.7 0.15 11.2 1.9 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Dicty_REP PF05086.7 EFE44528.1 - 0.12 10.0 4.5 0.11 10.2 3.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Afi1 PF07792.7 EFE44528.1 - 0.13 12.2 4.7 0.13 12.2 3.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BTV_NS2 PF04514.7 EFE44528.1 - 0.22 10.3 8.2 0.21 10.4 5.7 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF3464 PF11947.3 EFE44528.1 - 0.22 10.9 11.6 0.29 10.5 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) CDC45 PF02724.9 EFE44528.1 - 0.34 8.9 9.9 0.31 9.0 6.8 1.0 1 0 0 1 1 1 0 CDC45-like protein AUX_IAA PF02309.11 EFE44528.1 - 0.34 10.6 6.1 0.33 10.6 4.2 1.1 1 0 0 1 1 1 0 AUX/IAA family RXT2_N PF08595.6 EFE44528.1 - 0.58 9.9 10.4 0.76 9.5 7.2 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Herpes_UL95 PF03038.9 EFE44528.1 - 0.69 8.7 3.1 0.7 8.7 2.2 1.0 1 0 0 1 1 1 0 UL95 family SAGA-Tad1 PF12767.2 EFE44528.1 - 0.69 9.5 7.4 0.76 9.3 5.1 1.0 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF3306 PF11748.3 EFE44528.1 - 0.76 10.4 8.8 0.86 10.2 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Serinc PF03348.10 EFE44528.1 - 0.86 8.2 2.8 0.85 8.2 2.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Tom22 PF04281.8 EFE44528.1 - 0.89 9.0 5.8 1 8.8 4.0 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 SAPS PF04499.10 EFE44528.1 - 1 7.8 6.1 1 7.9 4.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TRAP_alpha PF03896.11 EFE44528.1 - 1.1 8.1 9.8 1.3 7.9 6.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.17 EFE44528.1 - 1.3 8.0 3.4 1.2 8.1 2.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.1 EFE44528.1 - 1.5 8.5 8.0 1.7 8.3 5.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Rtf2 PF04641.7 EFE44528.1 - 1.8 7.6 15.6 2.1 7.4 10.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF3504 PF12012.3 EFE44528.1 - 2.1 8.0 7.5 2.2 7.9 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) Daxx PF03344.10 EFE44528.1 - 2.3 6.6 16.0 2.6 6.4 11.1 1.0 1 0 0 1 1 1 0 Daxx Family Sec10 PF07393.6 EFE44528.1 - 2.9 5.9 7.5 3.3 5.7 5.2 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec10 DUF3449 PF11931.3 EFE44528.1 - 3.2 7.2 12.8 3.7 7.0 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Paramyxo_ncap PF00973.14 EFE44528.1 - 3.4 6.2 5.4 3.3 6.3 3.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Pap_E4 PF02711.9 EFE44528.1 - 3.6 8.4 7.3 5 8.0 5.1 1.3 1 0 0 1 1 1 0 E4 protein NPR3 PF03666.8 EFE44528.1 - 3.9 5.9 13.8 4.3 5.7 9.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 U79_P34 PF03064.11 EFE44528.1 - 3.9 6.9 13.4 4.1 6.8 9.3 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Ycf1 PF05758.7 EFE44528.1 - 4.1 4.9 9.3 3.6 5.1 6.4 1.0 1 0 0 1 1 1 0 Ycf1 PPP4R2 PF09184.6 EFE44528.1 - 5 6.5 17.9 5.6 6.4 12.4 1.0 1 0 0 1 1 1 0 PPP4R2 Tim54 PF11711.3 EFE44528.1 - 5.3 5.5 11.1 5.6 5.4 7.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1510 PF07423.6 EFE44528.1 - 5.3 6.3 20.4 6 6.1 14.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF2457 PF10446.4 EFE44528.1 - 5.6 5.5 17.2 6.5 5.3 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RR_TM4-6 PF06459.7 EFE44528.1 - 6 6.6 11.8 6.3 6.6 8.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1764 PF08576.5 EFE44528.1 - 6.4 7.6 17.8 8.3 7.2 12.3 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) TLP-20 PF06088.6 EFE44528.1 - 6.4 6.4 11.3 8.1 6.0 7.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Gti1_Pac2 PF09729.4 EFE44528.1 - 6.4 6.6 8.1 7.5 6.3 5.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF1754 PF08555.5 EFE44528.1 - 6.8 7.3 25.3 8.6 7.0 17.5 1.1 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) PBP1_TM PF14812.1 EFE44528.1 - 7.6 6.9 21.1 12 6.3 14.6 1.5 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GAGA_bind PF06217.7 EFE44528.1 - 8 6.3 11.8 8.3 6.2 8.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family AIF_C PF14721.1 EFE44528.1 - 8.9 6.5 9.3 11 6.2 6.4 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Rhabdo_ncap PF00945.13 EFE44528.1 - 9 4.7 6.8 9.3 4.7 4.7 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein NUDIX_2 PF13869.1 EFE44530.1 - 8.6e-82 273.0 0.0 1e-81 272.7 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase DUF4316 PF14195.1 EFE44530.1 - 0.1 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) CoaE PF01121.15 EFE44531.1 - 1.4e-42 145.1 0.0 1.9e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 EFE44531.1 - 0.00013 22.7 0.0 0.00024 21.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFE44531.1 - 0.082 13.2 0.3 0.25 11.6 0.0 2.0 2 1 0 2 2 2 0 AAA domain 2TM PF13239.1 EFE44531.1 - 0.26 11.3 0.2 0.26 11.3 0.1 1.7 2 0 0 2 2 2 0 2TM domain SAPS PF04499.10 EFE44532.1 - 0.012 14.3 0.1 0.014 14.1 0.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ECH PF00378.15 EFE44533.1 - 5.7e-45 153.3 0.0 7.6e-45 152.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 EFE44533.1 - 0.024 14.4 0.0 0.056 13.2 0.0 1.6 2 0 0 2 2 2 0 Peptidase family S49 APH PF01636.18 EFE44535.1 - 1.4e-22 80.5 0.0 2.2e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE44535.1 - 4.9e-08 32.8 0.0 6.6e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 EFE44535.1 - 0.0026 17.1 0.0 0.029 13.7 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Fructosamin_kin PF03881.9 EFE44535.1 - 0.0045 16.0 0.0 0.16 10.9 0.0 2.1 2 0 0 2 2 2 1 Fructosamine kinase EcKinase PF02958.15 EFE44535.1 - 0.0099 15.0 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 EFE44535.1 - 0.016 13.8 0.0 0.027 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase PF00069.20 EFE44535.1 - 0.025 13.7 0.0 0.13 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain FMO-like PF00743.14 EFE44536.1 - 2.6e-18 65.5 0.4 3.2e-16 58.6 0.1 2.8 2 1 1 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFE44536.1 - 2e-16 60.7 0.0 6.4e-16 59.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE44536.1 - 5.6e-06 25.5 0.0 0.00016 20.7 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFE44536.1 - 0.0071 16.3 1.2 0.011 15.7 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFE44536.1 - 0.015 15.1 0.0 1.1 9.0 0.0 2.7 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFE44536.1 - 0.031 14.0 0.0 0.91 9.2 0.0 3.0 3 0 0 3 3 3 0 FAD-NAD(P)-binding Exo_endo_phos PF03372.18 EFE44537.1 - 1.8e-24 87.0 0.0 3.7e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BBS2_Mid PF14783.1 EFE44537.1 - 0.15 11.8 0.1 0.44 10.3 0.0 1.8 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region ERG4_ERG24 PF01222.12 EFE44538.1 - 2.2e-145 484.4 9.9 2.7e-145 484.2 6.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 EFE44538.1 - 5.4e-05 22.6 0.8 0.00012 21.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) Proteasome PF00227.21 EFE44539.1 - 9.2e-39 132.6 0.1 3.5e-38 130.8 0.1 1.7 1 1 0 1 1 1 1 Proteasome subunit Aldo_ket_red PF00248.16 EFE44540.1 - 1e-44 152.5 0.0 2.6e-43 147.8 0.0 2.2 1 1 0 1 1 1 1 Aldo/keto reductase family APH PF01636.18 EFE44540.1 - 3.5e-10 40.0 0.0 8.5e-10 38.7 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family FAD-oxidase_C PF02913.14 EFE44541.1 - 3.7e-53 180.3 0.0 5.7e-53 179.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EFE44541.1 - 1.5e-35 121.6 0.3 3e-35 120.7 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain Pkinase PF00069.20 EFE44542.1 - 3.2e-72 242.7 0.0 4.6e-72 242.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44542.1 - 2.7e-48 164.3 0.0 4.1e-48 163.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE44542.1 - 1.9e-05 23.7 0.0 0.00016 20.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EFE44542.1 - 0.043 13.5 0.0 5.4 6.6 0.0 2.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family RicinB_lectin_2 PF14200.1 EFE44543.1 - 0.11 12.8 0.0 0.32 11.3 0.0 1.7 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like UPF0262 PF06793.7 EFE44545.1 - 0.093 12.4 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) CAP59_mtransfer PF11735.3 EFE44546.1 - 4.4e-65 219.2 1.0 8.3e-50 169.2 0.2 2.2 1 1 1 2 2 2 2 Cryptococcal mannosyltransferase 1 DUF4048 PF13257.1 EFE44547.1 - 2.4e-82 276.4 19.5 2.4e-82 276.4 13.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4048) TMEM247 PF15444.1 EFE44547.1 - 0.9 9.3 2.5 1.1 9.0 0.1 2.1 2 1 0 2 2 2 0 Transmembrane protein 247 Golgin_A5 PF09787.4 EFE44547.1 - 6.8 5.0 16.1 0.019 13.5 0.4 2.4 2 0 0 2 2 2 0 Golgin subfamily A member 5 Tim17 PF02466.14 EFE44548.1 - 2.2e-47 160.2 6.8 2.4e-47 160.1 4.7 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_Omp PF13488.1 EFE44548.1 - 0.0099 15.4 4.9 0.0099 15.4 3.4 2.5 3 0 0 3 3 3 1 Glycine zipper Gly-zipper_OmpA PF13436.1 EFE44548.1 - 3.5 7.3 9.2 3.7 7.2 3.2 2.3 2 1 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Oxidored_molyb PF00174.14 EFE44549.1 - 2.4e-53 179.9 0.0 3.5e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 EFE44549.1 - 9.7e-30 102.8 1.2 2.3e-29 101.6 0.8 1.6 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Big_3_4 PF13754.1 EFE44549.1 - 0.021 15.1 0.1 0.075 13.3 0.1 1.9 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) PALP PF00291.20 EFE44550.1 - 5.8e-53 180.1 0.2 7.6e-53 179.7 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cnd3 PF12719.2 EFE44551.1 - 1.6e-95 319.5 0.0 8.8e-95 317.1 0.0 2.1 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 EFE44551.1 - 4.9e-11 42.7 4.8 1.2e-06 28.7 0.1 4.6 2 2 2 4 4 4 3 HEAT repeats HEAT_EZ PF13513.1 EFE44551.1 - 1.2e-05 25.6 6.4 0.064 13.7 0.1 5.3 5 1 0 5 5 5 2 HEAT-like repeat HEAT PF02985.17 EFE44551.1 - 2.6e-05 23.9 5.1 0.1 12.7 0.0 5.8 7 0 0 7 7 7 1 HEAT repeat RICTOR_N PF14664.1 EFE44551.1 - 0.031 12.8 0.6 0.93 8.0 0.0 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term MMS19_N PF14500.1 EFE44551.1 - 0.033 13.4 0.1 0.18 11.0 0.0 2.3 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II zf-RanBP PF00641.13 EFE44552.1 - 1.1e-19 69.1 8.4 4.8e-10 38.3 1.1 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 EFE44552.1 - 2.1e-07 30.4 0.0 5e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE44552.1 - 4e-05 23.4 0.0 0.00026 20.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) HasA PF06438.7 EFE44552.1 - 0.087 12.2 1.2 0.15 11.4 0.8 1.3 1 0 0 1 1 1 0 Heme-binding protein A (HasA) DZR PF12773.2 EFE44552.1 - 2.2 8.1 9.4 0.65 9.8 0.8 2.4 2 0 0 2 2 2 0 Double zinc ribbon Fungal_trans PF04082.13 EFE44553.1 - 5e-18 64.8 1.3 1.5e-17 63.3 0.9 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE44553.1 - 5.3e-06 26.2 8.2 1e-05 25.3 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SNase PF00565.12 EFE44555.1 - 2.4e-80 265.8 0.2 5.7e-26 90.8 0.0 5.4 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.19 EFE44555.1 - 2.2e-24 85.5 0.0 9e-24 83.6 0.0 2.0 2 0 0 2 2 2 1 Tudor domain SMN PF06003.7 EFE44555.1 - 0.00012 21.3 0.0 0.00021 20.5 0.0 1.3 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) DUF3297 PF11730.3 EFE44555.1 - 0.032 13.9 0.1 0.13 11.9 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) CRAL_TRIO PF00650.15 EFE44556.1 - 1.7e-24 86.0 0.0 2.6e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFE44556.1 - 1.5e-08 34.6 0.0 3.9e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF2208 PF09973.4 EFE44556.1 - 0.2 10.8 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) HMG-CoA_red PF00368.13 EFE44557.1 - 5.5e-152 505.7 5.8 7e-152 505.4 4.0 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.3 EFE44557.1 - 8.5e-12 44.7 6.2 8.5e-12 44.7 4.3 2.6 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation HPIH PF13323.1 EFE44557.1 - 1.1e-11 44.5 0.1 2.5e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Patched PF02460.13 EFE44557.1 - 3.8e-06 25.1 2.3 5.9e-06 24.5 1.6 1.2 1 0 0 1 1 1 1 Patched family DUF3328 PF11807.3 EFE44557.1 - 7.3 6.1 5.1 12 5.4 0.0 3.5 5 0 0 5 5 5 0 Domain of unknown function (DUF3328) CVNH PF08881.5 EFE44558.1 - 5.3e-28 97.3 0.4 6.4e-28 97.0 0.3 1.1 1 0 0 1 1 1 1 CVNH domain PBP1_TM PF14812.1 EFE44559.1 - 7.5e-05 22.9 2.1 0.00016 21.8 1.5 1.6 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal OapA_N PF08525.6 EFE44559.1 - 0.1 12.3 1.0 0.1 12.3 0.7 2.4 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif Caldesmon PF02029.10 EFE44559.1 - 1.8 6.8 10.3 2.2 6.5 7.1 1.0 1 0 0 1 1 1 0 Caldesmon Orbi_VP6 PF01516.11 EFE44559.1 - 2.2 7.2 5.7 2.8 6.9 3.9 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 Daxx PF03344.10 EFE44559.1 - 8.6 4.7 8.2 11 4.3 5.7 1.0 1 0 0 1 1 1 0 Daxx Family GIT_SHD PF08518.6 EFE44560.1 - 3.1e-22 77.6 6.7 8.4e-13 47.4 0.6 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT APG6 PF04111.7 EFE44560.1 - 0.00019 20.5 29.1 0.00069 18.7 2.3 2.6 2 0 0 2 2 2 2 Autophagy protein Apg6 TPR_MLP1_2 PF07926.7 EFE44560.1 - 0.0025 17.5 14.9 0.0025 17.5 10.3 3.9 5 0 0 5 5 5 2 TPR/MLP1/MLP2-like protein DUF3595 PF12166.3 EFE44560.1 - 0.17 10.6 1.0 0.3 9.8 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) IncA PF04156.9 EFE44560.1 - 9.4 5.7 42.9 0.26 10.8 4.9 3.2 2 1 0 3 3 3 0 IncA protein Pro_isomerase PF00160.16 EFE44561.1 - 7.3e-40 136.7 0.8 9.7e-40 136.3 0.2 1.4 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RNase_PH PF01138.16 EFE44562.1 - 4.5e-34 117.6 0.4 1.1e-33 116.2 0.1 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 Coiled PF05710.7 EFE44562.1 - 0.016 15.6 3.4 0.016 15.6 2.3 1.7 2 0 0 2 2 2 0 Coiled coil ProSAAS PF07259.7 EFE44562.1 - 0.09 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 ProSAAS precursor SNF2_N PF00176.18 EFE44563.1 - 8e-56 189.0 0.0 1.2e-55 188.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.1 EFE44563.1 - 2.6e-26 91.2 0.1 6.3e-26 90.0 0.1 1.7 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.26 EFE44563.1 - 6.2e-14 51.6 0.0 2.4e-13 49.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE44563.1 - 8.2e-05 22.5 0.1 0.0013 18.6 0.0 2.9 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Ssu72 PF04722.8 EFE44564.1 - 7.6e-84 279.8 0.0 8.9e-84 279.6 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein zf-CCHC PF00098.18 EFE44565.1 - 0.021 14.7 2.7 0.049 13.5 1.9 1.6 1 0 0 1 1 1 0 Zinc knuckle PyrI_C PF02748.10 EFE44565.1 - 0.03 13.7 0.5 7.4 6.0 0.1 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.10 EFE44565.1 - 0.13 12.0 3.9 6.7 6.5 0.1 2.5 2 0 0 2 2 2 0 BED zinc finger zf-CHCC PF10276.4 EFE44565.1 - 0.18 11.6 4.6 1.3 8.9 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger domain DUF2946 PF11162.3 EFE44565.1 - 2.2 8.4 7.7 0.28 11.3 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2946) Acyl-CoA_dh_1 PF00441.19 EFE44566.1 - 8e-19 68.2 0.3 7.5e-18 65.0 0.0 2.5 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFE44566.1 - 1.1e-05 24.8 0.7 9.1e-05 21.9 0.5 2.5 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Oxysterol_BP PF01237.13 EFE44567.1 - 1.1e-73 247.7 0.0 1.5e-73 247.3 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein DUF536 PF04394.9 EFE44567.1 - 0.34 10.6 1.8 0.62 9.8 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF536 p450 PF00067.17 EFE44568.1 - 9.2e-22 77.1 0.0 1.1e-21 76.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 EFE44569.1 - 2.6e-55 187.7 0.0 6e-53 180.0 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Terpene_synth_C PF03936.11 EFE44570.1 - 0.0087 15.3 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain adh_short PF00106.20 EFE44571.1 - 4.7e-16 59.1 0.0 8.5e-16 58.3 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE44571.1 - 5.5e-05 23.0 0.0 0.00011 22.0 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE44571.1 - 0.00017 21.3 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 EFE44571.1 - 0.00028 20.9 0.0 0.00047 20.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 EFE44571.1 - 0.022 14.7 0.0 0.052 13.5 0.0 1.6 2 0 0 2 2 2 0 NADH(P)-binding Epimerase PF01370.16 EFE44571.1 - 0.031 13.7 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 EFE44571.1 - 0.12 12.8 0.2 0.47 10.9 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent CtIP_N PF10482.4 EFE44573.1 - 0.0087 15.8 1.2 0.015 15.0 0.8 1.4 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain DUF2408 PF10303.4 EFE44573.1 - 0.035 14.2 0.3 0.06 13.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Hat1_N PF10394.4 EFE44574.1 - 8.7e-43 146.1 0.3 1.9e-42 145.0 0.2 1.6 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus ENT PF03735.9 EFE44574.1 - 0.045 13.4 0.2 3.9 7.2 0.1 3.0 3 0 0 3 3 3 0 ENT domain DUF917 PF06032.7 EFE44575.1 - 2.6e-124 414.3 0.1 4.1e-123 410.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 EFE44575.1 - 2.1e-50 171.4 5.4 3.7e-50 170.6 3.7 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase StbA PF06406.6 EFE44575.1 - 0.015 14.2 0.1 1.7 7.4 0.0 2.3 2 0 0 2 2 2 0 StbA protein Hydant_A_N PF05378.8 EFE44575.1 - 0.059 12.8 5.6 5.5 6.4 0.0 3.4 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase N-terminal region Transp_cyt_pur PF02133.10 EFE44577.1 - 2e-99 333.1 37.1 2.4e-99 332.8 25.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Zip PF02535.17 EFE44578.1 - 3.7e-32 111.6 18.9 5.5e-26 91.3 12.6 3.1 2 1 0 2 2 2 2 ZIP Zinc transporter WD40 PF00400.27 EFE44579.1 - 1.7e-51 170.3 20.6 4.2e-09 35.9 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 EFE44579.1 - 1.6e-10 40.5 0.6 3e-10 39.6 0.4 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.3 EFE44579.1 - 9.6e-10 37.2 7.2 0.0029 15.8 0.7 4.9 1 1 4 5 5 5 4 Nucleoporin Nup120/160 F-box PF00646.28 EFE44579.1 - 0.00066 19.2 0.6 0.0016 18.0 0.4 1.7 1 0 0 1 1 1 1 F-box domain Nucleoporin_N PF08801.6 EFE44579.1 - 0.012 14.3 0.9 0.089 11.5 0.1 2.6 1 1 1 2 2 2 0 Nup133 N terminal like PQQ_3 PF13570.1 EFE44579.1 - 0.044 14.0 0.3 42 4.5 0.0 4.4 4 1 1 5 5 5 0 PQQ-like domain PQQ_2 PF13360.1 EFE44579.1 - 0.06 12.7 3.3 1.7 8.0 0.1 3.0 1 1 1 3 3 3 0 PQQ-like domain PyrBI_leader PF08052.6 EFE44579.1 - 0.094 12.5 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 PyrBI operon leader peptide PBP1_TM PF14812.1 EFE44580.1 - 0.069 13.4 1.0 0.069 13.4 0.7 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3245 PF11595.3 EFE44580.1 - 0.13 12.4 2.0 0.15 12.3 1.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Bd3614_N PF14442.1 EFE44580.1 - 0.26 11.2 2.0 0.26 11.2 1.4 1.0 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal MRC1 PF09444.5 EFE44580.1 - 3.2 8.0 6.1 3.2 8.0 4.2 1.0 1 0 0 1 1 1 0 MRC1-like domain Sugar_tr PF00083.19 EFE44583.1 - 1.9e-84 283.8 25.0 1.9e-84 283.8 17.3 1.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFE44583.1 - 1.1e-10 40.7 48.1 1.1e-06 27.6 11.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_S64 PF08192.6 EFE44584.1 - 1.2e-06 27.1 0.0 2e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S64 Trypsin_2 PF13365.1 EFE44584.1 - 0.0021 18.0 0.0 0.0035 17.3 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 EFE44584.1 - 0.0089 15.6 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin DUF883 PF05957.8 EFE44586.1 - 0.25 11.7 5.7 0.53 10.7 3.9 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) FHA PF00498.21 EFE44587.1 - 2.3e-12 46.8 0.0 4.2e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 FHA domain MFS_1 PF07690.11 EFE44588.1 - 3.8e-33 114.6 52.8 5.5e-31 107.5 19.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans_2 PF11951.3 EFE44589.1 - 2.2e-11 42.9 4.1 2.6e-11 42.7 2.8 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3615 PF12274.3 EFE44589.1 - 0.069 13.4 0.3 0.54 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3615) DnaJ PF00226.26 EFE44590.1 - 8.5e-08 31.8 0.1 1.7e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Abhydrolase_3 PF07859.8 EFE44591.1 - 8.4e-25 87.5 0.0 2.4e-11 43.6 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF2424 PF10340.4 EFE44591.1 - 0.0009 17.9 0.5 0.012 14.2 0.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2424) PAT1 PF09770.4 EFE44594.1 - 2.8 6.0 24.2 3.5 5.7 16.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NicO PF03824.11 EFE44596.1 - 0.032 13.5 1.0 0.047 13.0 0.7 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein F-box-like PF12937.2 EFE44597.1 - 0.00048 19.7 0.0 0.00099 18.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like XPG_I_2 PF12813.2 EFE44597.1 - 0.13 11.7 0.1 0.21 11.0 0.1 1.2 1 0 0 1 1 1 0 XPG domain containing Ead_Ea22 PF13935.1 EFE44598.1 - 0.24 11.7 3.8 2.2 8.6 1.1 2.4 1 1 1 2 2 2 0 Ead/Ea22-like protein Mucin PF01456.12 EFE44598.1 - 0.48 10.1 17.9 0.78 9.5 12.4 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein NPR2 PF06218.6 EFE44599.1 - 1.2e-105 353.7 0.0 2.5e-105 352.6 0.0 1.4 2 0 0 2 2 2 1 Nitrogen permease regulator 2 NPR3 PF03666.8 EFE44599.1 - 0.15 10.5 0.0 1.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Ada3 PF10198.4 EFE44600.1 - 1.2e-41 141.5 0.5 2e-41 140.7 0.0 1.7 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 zf-RING_2 PF13639.1 EFE44601.1 - 1.1e-11 44.2 8.6 1.1e-11 44.2 5.9 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFE44601.1 - 3.1e-07 30.3 4.8 7e-07 29.1 3.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE44601.1 - 3e-06 26.7 3.4 5.7e-06 25.8 2.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFE44601.1 - 6.6e-06 25.7 3.1 1.2e-05 24.8 2.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 EFE44601.1 - 5.6e-05 23.1 2.3 0.00013 22.0 1.6 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 EFE44601.1 - 0.00013 21.5 5.0 0.00023 20.7 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFE44601.1 - 0.018 14.8 1.9 0.039 13.7 1.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1049 PF06305.6 EFE44601.1 - 0.2 11.1 1.2 0.47 9.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Prok-RING_4 PF14447.1 EFE44601.1 - 5.6 6.5 8.4 30 4.2 5.8 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 FRG1 PF06229.7 EFE44602.1 - 2.7e-44 150.9 0.4 1e-43 149.0 0.3 1.8 1 1 0 1 1 1 1 FRG1-like family ADH_N PF08240.7 EFE44603.1 - 1.6e-35 121.1 3.6 2.7e-35 120.3 2.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFE44603.1 - 1e-15 57.4 0.0 1.6e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.1 EFE44603.1 - 0.01 16.0 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Gp_dh_N PF00044.19 EFE44603.1 - 0.023 14.6 0.0 0.054 13.4 0.0 1.6 1 1 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Methyltransf_18 PF12847.2 EFE44603.1 - 0.025 15.1 0.0 0.05 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Saccharop_dh PF03435.13 EFE44603.1 - 0.032 13.1 0.0 0.042 12.8 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase FAD_binding_3 PF01494.14 EFE44603.1 - 0.053 12.5 0.6 0.085 11.8 0.4 1.2 1 0 0 1 1 1 0 FAD binding domain DUF2318 PF10080.4 EFE44603.1 - 0.12 12.2 0.4 11 5.8 0.1 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) NADH_4Fe-4S PF10589.4 EFE44603.1 - 0.13 11.4 1.1 0.47 9.6 0.8 1.9 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region THDPS_N_2 PF14805.1 EFE44603.1 - 0.14 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal ThiF PF00899.16 EFE44603.1 - 0.15 11.8 0.5 19 5.0 0.0 2.3 1 1 0 2 2 2 0 ThiF family HECT PF00632.20 EFE44604.1 - 7.1e-66 222.5 0.0 1e-65 222.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ribosomal_L15e PF00827.12 EFE44605.1 - 2.5e-87 291.3 12.9 2.9e-87 291.1 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 DBR1 PF05011.8 EFE44607.1 - 6.3e-46 155.8 0.0 1.5e-45 154.6 0.0 1.6 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 EFE44607.1 - 8.3e-09 35.1 2.9 1.5e-08 34.3 2.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase API5 PF05918.6 EFE44607.1 - 0.085 11.3 1.6 0.12 10.8 1.1 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) GRP PF07172.6 EFE44607.1 - 0.22 12.0 13.8 0.61 10.5 9.6 1.8 1 0 0 1 1 1 0 Glycine rich protein family DUF2435 PF10363.4 EFE44608.1 - 1.2e-23 82.8 0.1 6.5e-23 80.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2435) DUF2411 PF10304.4 EFE44608.1 - 2.9e-09 36.1 0.0 7.7e-09 34.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2411) Polysacc_deac_1 PF01522.16 EFE44609.1 - 1.1e-28 99.3 0.0 1.8e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.14 EFE44609.1 - 2.9e-07 30.3 39.6 4.9e-06 26.4 9.8 2.5 2 0 0 2 2 2 2 Chitin recognition protein U3_snoRNA_assoc PF08297.6 EFE44610.1 - 1.3 9.2 9.7 0.069 13.3 1.3 2.7 2 1 0 2 2 2 0 U3 snoRNA associated NST1 PF13945.1 EFE44610.1 - 5.5 7.0 8.3 3.2 7.7 0.6 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator FAD_binding_3 PF01494.14 EFE44611.1 - 5.6e-23 81.5 0.0 7.2e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFE44611.1 - 2e-09 36.8 2.0 0.00021 20.3 0.5 3.0 1 1 2 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFE44611.1 - 9.8e-05 22.6 0.2 0.0011 19.2 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFE44611.1 - 0.00049 20.0 0.4 0.0011 18.9 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFE44611.1 - 0.002 17.0 0.6 0.0034 16.2 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain SE PF08491.5 EFE44611.1 - 0.023 13.5 0.0 0.035 12.9 0.0 1.4 1 1 0 1 1 1 0 Squalene epoxidase Pyr_redox_2 PF07992.9 EFE44611.1 - 0.026 14.4 0.1 0.085 12.7 0.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFE44611.1 - 0.027 13.0 0.1 4.3 5.8 0.0 2.8 3 0 0 3 3 3 0 Tryptophan halogenase Thi4 PF01946.12 EFE44611.1 - 0.047 12.7 0.1 0.073 12.1 0.1 1.4 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.13 EFE44611.1 - 0.072 12.7 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 EFE44611.1 - 0.16 11.4 0.3 0.35 10.3 0.2 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.17 EFE44611.1 - 0.27 10.0 0.8 0.4 9.4 0.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trypsin_2 PF13365.1 EFE44612.1 - 0.00014 21.7 0.0 0.00032 20.6 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S46 PF10459.4 EFE44612.1 - 0.14 10.5 0.0 0.22 9.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase S46 Clathrin PF00637.15 EFE44613.1 - 3.6e-20 72.0 3.4 2.4e-17 62.8 0.9 2.7 2 0 0 2 2 2 2 Region in Clathrin and VPS VPS11_C PF12451.3 EFE44613.1 - 9.1e-18 63.8 0.0 2.2e-17 62.6 0.0 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-RING_5 PF14634.1 EFE44613.1 - 0.00032 20.3 6.1 0.00072 19.2 4.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 EFE44613.1 - 0.0017 18.1 6.3 0.0034 17.1 4.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFE44613.1 - 0.003 17.5 5.6 0.006 16.5 3.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TPR_11 PF13414.1 EFE44613.1 - 0.0096 15.5 0.0 0.044 13.4 0.0 2.2 1 0 0 1 1 1 1 TPR repeat zf-rbx1 PF12678.2 EFE44613.1 - 0.022 14.8 3.6 0.041 13.9 2.5 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger TPR_14 PF13428.1 EFE44613.1 - 0.022 15.3 0.0 2.5 8.9 0.0 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-C3HC4 PF00097.20 EFE44613.1 - 0.046 13.3 5.5 0.088 12.4 3.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.1 EFE44613.1 - 0.051 13.5 4.3 0.97 9.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFE44613.1 - 0.067 13.1 0.6 0.51 10.3 0.1 2.8 2 0 0 2 2 1 0 Tetratricopeptide repeat zf-RING_6 PF14835.1 EFE44613.1 - 0.11 12.2 1.2 0.25 11.1 0.8 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.1 EFE44613.1 - 0.17 11.5 5.6 0.35 10.5 3.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFE44613.1 - 0.45 10.3 2.3 1.3 8.9 1.6 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_8 PF13181.1 EFE44613.1 - 1 9.2 6.0 0.33 10.8 0.1 3.2 5 0 0 5 5 3 0 Tetratricopeptide repeat adh_short_C2 PF13561.1 EFE44614.1 - 3.6e-29 102.2 0.0 4.2e-29 102.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFE44614.1 - 2.8e-28 98.9 0.1 3.5e-28 98.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFE44614.1 - 4.6e-15 55.7 0.1 6.1e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 KR domain zf-ZPR1 PF03367.8 EFE44615.1 - 1.2e-100 333.3 0.0 2.8e-49 166.3 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zf-ISL3 PF14690.1 EFE44615.1 - 0.015 15.3 8.0 3.1 7.9 0.4 3.4 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 UPF0547 PF10571.4 EFE44615.1 - 0.022 14.4 11.5 0.61 9.8 0.2 3.3 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 HypA PF01155.14 EFE44615.1 - 0.032 13.9 1.8 1.4 8.6 0.0 2.6 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family Cys_rich_KTR PF14205.1 EFE44615.1 - 0.25 10.8 3.0 0.99 8.9 0.1 2.6 3 0 0 3 3 3 0 Cysteine-rich KTR Elf1 PF05129.8 EFE44615.1 - 0.46 10.2 5.3 4.1 7.1 0.0 2.7 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like zinc-ribbons_6 PF07191.7 EFE44615.1 - 0.78 9.5 4.3 2.6 7.9 0.1 2.9 2 1 0 2 2 2 0 zinc-ribbons zf-H2C2_2 PF13465.1 EFE44615.1 - 2.8 8.4 9.6 4.9 7.6 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-ribbon_3 PF13248.1 EFE44615.1 - 7.7 5.8 12.5 1.7 7.9 0.2 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Pro_isomerase PF00160.16 EFE44616.1 - 5.1e-15 56.0 0.0 6.4e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Arrestin_C PF02752.17 EFE44617.1 - 1.5e-15 57.5 0.0 4.2e-15 56.0 0.0 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain tRNA_int_end_N2 PF12928.2 EFE44618.1 - 5e-33 112.3 0.0 7.6e-33 111.8 0.0 1.3 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.9 EFE44618.1 - 0.0039 16.6 0.0 0.0078 15.7 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain dUTPase PF00692.14 EFE44618.1 - 0.15 11.4 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 dUTPase Pkinase PF00069.20 EFE44619.1 - 8.5e-07 28.3 0.0 1.9e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFE44619.1 - 2.4e-06 27.4 1.1 2.3e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE44619.1 - 0.00049 19.2 0.0 0.0013 17.8 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE44619.1 - 0.0014 18.2 0.0 0.019 14.5 0.0 2.6 3 0 0 3 3 3 1 Choline/ethanolamine kinase HSDR_N_2 PF13588.1 EFE44619.1 - 0.0025 17.6 0.2 1.1 9.0 0.0 3.3 3 0 0 3 3 3 1 Type I restriction enzyme R protein N terminus (HSDR_N) SR-25 PF10500.4 EFE44619.1 - 0.017 14.5 12.2 0.012 15.0 3.7 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein adh_short PF00106.20 EFE44620.1 - 1.5e-22 80.2 5.3 2.9e-21 76.0 3.7 2.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE44620.1 - 5.6e-11 42.6 0.2 1.1e-10 41.7 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE44620.1 - 7.3e-08 32.2 3.5 2.3e-06 27.4 2.5 2.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE44620.1 - 2.1e-06 27.3 0.0 3.5e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFE44620.1 - 0.002 17.0 0.0 0.0038 16.1 0.0 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EFE44620.1 - 0.0031 16.4 0.0 0.0041 16.0 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein Shikimate_DH PF01488.15 EFE44620.1 - 0.015 15.4 0.1 1.6 8.7 0.0 3.0 2 1 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.16 EFE44621.1 - 3e-42 143.6 0.0 6.2e-42 142.6 0.0 1.6 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 EFE44621.1 - 5.2e-28 96.4 0.9 1.1e-27 95.4 0.6 1.6 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UAE_UbL PF14732.1 EFE44621.1 - 1.2e-22 79.7 0.4 2.9e-22 78.5 0.3 1.7 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.4 EFE44621.1 - 3.5e-22 77.5 1.6 3.5e-22 77.5 1.1 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.1 EFE44621.1 - 0.00016 21.9 0.0 0.00054 20.1 0.0 1.9 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.15 EFE44621.1 - 0.007 16.4 0.0 0.017 15.2 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.22 EFE44621.1 - 0.056 13.8 0.1 3.5 8.1 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Glt_symporter PF03616.9 EFE44621.1 - 0.19 10.2 0.1 0.28 9.6 0.0 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF2419 PF10343.4 EFE44622.1 - 1.9e-137 457.2 0.1 2.3e-137 457.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2419) ORC6 PF05460.8 EFE44623.1 - 5.7e-37 127.6 0.2 7.8e-37 127.1 0.2 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Senescence_reg PF04520.8 EFE44623.1 - 0.00018 22.0 2.9 0.015 15.7 0.2 2.3 2 0 0 2 2 2 2 Senescence regulator Amidase PF01425.16 EFE44624.1 - 4.8e-81 272.8 0.0 5.8e-81 272.5 0.0 1.1 1 0 0 1 1 1 1 Amidase DNA_pol_delta_4 PF04081.8 EFE44625.1 - 3.1e-12 46.8 5.6 1.4e-11 44.7 3.9 2.1 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 GAGA_bind PF06217.7 EFE44625.1 - 0.54 10.1 8.4 0.72 9.7 5.8 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family APH PF01636.18 EFE44628.1 - 1.7e-14 54.1 0.1 2.8e-14 53.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE44628.1 - 0.0042 16.6 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase CRC_subunit PF08624.5 EFE44629.1 - 4.4e-55 185.4 0.2 6.2e-55 184.9 0.1 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit CAP_GLY PF01302.20 EFE44630.1 - 1.4e-16 59.9 0.3 3.9e-16 58.4 0.2 1.8 1 0 0 1 1 1 1 CAP-Gly domain Spc7 PF08317.6 EFE44630.1 - 0.0014 17.3 17.9 0.095 11.3 5.1 3.1 2 1 2 4 4 4 4 Spc7 kinetochore protein AAA_13 PF13166.1 EFE44630.1 - 0.023 13.1 12.5 0.031 12.7 2.0 2.1 1 1 1 2 2 2 0 AAA domain Myosin_tail_1 PF01576.14 EFE44630.1 - 0.058 11.1 26.5 0.43 8.2 13.9 2.0 2 0 0 2 2 2 0 Myosin tail DUF1664 PF07889.7 EFE44630.1 - 0.57 9.9 12.7 4 7.2 1.8 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) PVL_ORF50 PF07768.6 EFE44630.1 - 1 9.3 5.1 0.19 11.7 0.2 2.2 1 1 1 2 2 2 0 PVL ORF-50-like family IncA PF04156.9 EFE44630.1 - 1.9 8.0 32.4 5.7 6.4 0.3 3.2 2 1 1 3 3 3 0 IncA protein DUF745 PF05335.8 EFE44630.1 - 2.9 7.3 10.6 0.61 9.5 2.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Syntaxin-6_N PF09177.6 EFE44630.1 - 3.1 8.2 10.6 7 7.1 0.0 3.8 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF1423 PF07227.6 EFE44630.1 - 6 5.4 9.0 17 3.8 4.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1423) NPV_P10 PF05531.7 EFE44630.1 - 6.5 7.0 14.0 44 4.4 0.0 4.3 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Sed5p PF11416.3 EFE44630.1 - 9 5.8 7.1 0.78 9.2 0.7 2.2 2 0 0 2 2 2 0 Integral membrane protein Sed5p Pkinase PF00069.20 EFE44631.1 - 1.3e-35 122.8 0.0 2e-21 76.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44631.1 - 1.2e-11 44.2 0.0 6.4e-09 35.2 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFE44631.1 - 0.005 15.8 0.0 1.8 7.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 EFE44631.1 - 0.0061 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3632 PF12311.3 EFE44632.1 - 4.7e-17 62.3 0.0 6.2e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) OPT PF03169.10 EFE44633.1 - 3.5e-69 233.8 44.0 1.1e-63 215.7 26.2 2.1 1 1 1 2 2 2 2 OPT oligopeptide transporter protein PWWP PF00855.12 EFE44634.1 - 2.9e-15 56.2 7.1 6.7e-14 51.8 4.9 3.2 1 1 0 1 1 1 1 PWWP domain PPP4R2 PF09184.6 EFE44634.1 - 0.0094 15.5 15.6 0.0094 15.5 10.8 4.1 3 1 1 4 4 4 1 PPP4R2 ComA PF02679.10 EFE44635.1 - 8.8e-25 87.1 0.0 1.7e-22 79.6 0.0 2.2 1 1 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) SpoIIE PF07228.7 EFE44636.1 - 1.1e-11 44.7 0.1 3.2e-10 40.0 0.1 2.1 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 EFE44636.1 - 8.5e-08 31.8 0.1 1.6e-07 30.9 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 EFE44636.1 - 1.4e-06 27.8 0.0 0.0015 18.0 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C WD40 PF00400.27 EFE44637.1 - 6.1e-45 149.5 24.5 4.6e-10 38.9 0.6 7.5 7 1 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.6 EFE44637.1 - 1.6e-14 52.8 0.8 2.8e-14 52.0 0.6 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Nbas_N PF15492.1 EFE44637.1 - 0.05 12.7 0.0 2.8 6.9 0.0 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.6 EFE44637.1 - 0.14 11.8 0.0 1.7 8.3 0.0 2.7 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A F-box-like PF12937.2 EFE44638.1 - 0.00014 21.5 0.4 0.00014 21.5 0.3 2.2 2 0 0 2 2 2 1 F-box-like ATP-synt_D PF01813.12 EFE44638.1 - 0.0065 16.0 0.1 0.013 15.0 0.1 1.4 1 0 0 1 1 1 1 ATP synthase subunit D F-box PF00646.28 EFE44638.1 - 0.0088 15.6 2.8 0.0091 15.6 0.8 1.9 2 0 0 2 2 2 1 F-box domain 3Beta_HSD PF01073.14 EFE44639.1 - 3.1e-09 35.9 0.6 5e-09 35.2 0.1 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFE44639.1 - 1.1e-06 28.3 0.7 7e-06 25.6 0.5 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFE44639.1 - 4.5e-05 23.5 0.5 0.00063 19.8 0.2 2.5 2 1 0 2 2 2 1 NADH(P)-binding NAD_binding_4 PF07993.7 EFE44639.1 - 0.00036 19.5 0.0 0.0012 17.8 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 EFE44639.1 - 0.027 13.7 0.1 0.18 10.9 0.1 2.0 2 0 0 2 2 2 0 NmrA-like family Polysacc_synt_2 PF02719.10 EFE44639.1 - 0.18 10.6 0.2 0.28 10.0 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HSCB_C PF07743.8 EFE44640.1 - 9.6e-19 67.6 1.1 1.8e-18 66.7 0.2 1.7 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 EFE44640.1 - 1.3e-10 40.8 0.1 1.1e-09 37.8 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain DUF4576 PF15144.1 EFE44641.1 - 1.6 8.3 5.8 0.2 11.3 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) CDC27 PF09507.5 EFE44641.1 - 4.6 6.3 27.4 6.4 5.8 19.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SHD1 PF03983.7 EFE44642.1 - 7.4e-36 121.6 0.1 1.3e-35 120.8 0.1 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.23 EFE44642.1 - 1e-33 114.4 4.0 5.3e-12 44.9 0.1 4.4 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.1 EFE44642.1 - 2.2e-30 103.9 6.2 6.4e-12 44.8 0.1 4.1 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.12 EFE44642.1 - 2.6e-23 81.2 0.2 3.6e-08 32.7 0.0 4.6 4 0 0 4 4 4 4 Variant SH3 domain SH3_3 PF08239.6 EFE44642.1 - 0.016 15.3 0.9 1.5 9.0 0.1 3.3 3 0 0 3 3 3 0 Bacterial SH3 domain SRP-alpha_N PF04086.8 EFE44642.1 - 0.14 11.5 2.9 0.46 9.8 2.0 1.8 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PRKCSH PF07915.8 EFE44643.1 - 1.7e-19 70.3 0.1 1.7e-19 70.3 0.1 3.1 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein STT3 PF02516.9 EFE44644.1 - 5.9e-120 401.4 42.9 2.6e-104 349.8 24.5 3.1 3 0 0 3 3 3 3 Oligosaccharyl transferase STT3 subunit APH PF01636.18 EFE44646.1 - 4.5e-17 62.5 0.0 1.1e-16 61.3 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE44646.1 - 3e-05 23.1 0.0 0.14 11.1 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFE44646.1 - 0.00017 21.2 0.0 0.0003 20.4 0.0 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 EFE44646.1 - 0.037 13.3 0.0 0.18 11.1 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Pkinase PF00069.20 EFE44646.1 - 0.11 11.6 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain APH_6_hur PF04655.9 EFE44646.1 - 0.12 11.5 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Pox_ser-thr_kin PF05445.6 EFE44646.1 - 0.13 11.0 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pirin PF02678.11 EFE44647.1 - 3.8e-32 110.3 0.1 9.8e-32 109.0 0.0 1.7 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 EFE44647.1 - 6.8e-25 87.1 0.0 2.2e-24 85.5 0.0 1.8 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 EFE44647.1 - 8.7e-05 21.9 1.7 0.0019 17.6 0.8 2.5 2 1 0 2 2 2 1 Cupin domain Tmem26 PF09772.4 EFE44647.1 - 0.21 10.8 0.4 0.31 10.2 0.3 1.2 1 0 0 1 1 1 0 Transmembrane protein 26 ATP-synt_8 PF00895.15 EFE44647.1 - 9.4 6.5 8.6 17 5.7 6.0 1.4 1 0 0 1 1 1 0 ATP synthase protein 8 PMT PF02366.13 EFE44648.1 - 8.3e-83 277.4 16.2 1.4e-82 276.7 11.2 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EFE44648.1 - 7.3e-21 74.5 1.0 4.1e-20 72.1 0.3 2.1 1 1 1 2 2 2 2 MIR domain WD40 PF00400.27 EFE44650.1 - 3.6e-17 61.5 7.6 8e-05 22.3 0.1 5.9 7 1 0 7 7 7 4 WD domain, G-beta repeat ATP-synt_E PF05680.7 EFE44651.1 - 9.9e-23 79.9 0.1 1e-22 79.8 0.1 1.1 1 0 0 1 1 1 1 ATP synthase E chain DUF3752 PF12572.3 EFE44651.1 - 0.046 13.8 0.5 0.055 13.5 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) Drf_GBD PF06371.8 EFE44651.1 - 0.13 11.6 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain PCI_Csn8 PF10075.4 EFE44652.1 - 1.2e-15 57.4 0.0 1.9e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 EFE44652.1 - 0.071 12.6 0.0 0.087 12.3 0.0 1.1 1 0 0 1 1 1 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI PF01399.22 EFE44652.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.8 1 1 0 1 1 1 0 PCI domain DUF3453 PF11935.3 EFE44653.1 - 1.5e-46 158.7 0.1 1.6e-40 139.0 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3453) Sds3 PF08598.6 EFE44654.1 - 4e-16 59.1 0.5 4e-16 59.1 0.3 3.5 2 2 0 2 2 2 1 Sds3-like IL13 PF03487.8 EFE44654.1 - 0.32 10.7 1.7 1.9 8.2 0.0 2.9 3 0 0 3 3 3 0 Interleukin-13 CCT PF06203.9 EFE44655.1 - 0.087 12.4 1.1 1.9 8.1 0.1 2.2 2 0 0 2 2 2 0 CCT motif DUF553 PF04473.7 EFE44655.1 - 0.15 11.2 0.7 0.54 9.5 0.5 1.9 1 1 0 1 1 1 0 Transglutaminase-like domain RRM_1 PF00076.17 EFE44656.1 - 7.9e-12 44.6 0.1 3.7e-07 29.6 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE44656.1 - 1.2e-08 34.6 0.0 0.0019 18.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE44656.1 - 4.3e-08 33.0 0.1 4e-05 23.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Daxx PF03344.10 EFE44656.1 - 3.2e-06 25.9 28.5 4.9e-06 25.3 19.7 1.3 1 0 0 1 1 1 1 Daxx Family DUF572 PF04502.8 EFE44656.1 - 0.5 9.5 32.6 1.1 8.4 22.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) GPI-anchored PF10342.4 EFE44657.1 - 9.3e-16 58.0 0.1 9.3e-16 58.0 0.1 2.8 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family NUFIP1 PF10453.4 EFE44658.1 - 6.5e-14 51.1 4.9 6.5e-14 51.1 3.4 4.6 2 1 3 5 5 5 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.19 EFE44658.1 - 1e-06 28.2 5.9 1.6e-06 27.6 4.1 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RNA_pol_Rbc25 PF08292.7 EFE44659.1 - 2.7e-15 56.6 1.5 3.4e-08 33.6 0.0 3.4 3 0 0 3 3 3 3 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 EFE44659.1 - 2.4e-13 49.9 0.1 5.3e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Cys_Met_Meta_PP PF01053.15 EFE44660.1 - 8.3e-67 225.1 0.3 9.3e-67 224.9 0.2 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EFE44660.1 - 4e-06 26.0 0.0 5.3e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EFE44660.1 - 8.3e-05 21.8 0.0 0.00012 21.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EFE44660.1 - 0.00048 18.9 0.1 0.00071 18.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFE44660.1 - 0.0005 19.2 0.7 0.0012 17.9 0.5 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Crinivirus_P26 PF07416.6 EFE44660.1 - 0.056 12.9 0.0 0.08 12.4 0.0 1.2 1 0 0 1 1 1 0 Crinivirus P26 protein AAA_33 PF13671.1 EFE44660.1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF1180 PF06679.7 EFE44661.1 - 3.1 7.6 4.4 3.8 7.3 2.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Peptidase_S8 PF00082.17 EFE44662.1 - 1.2e-48 165.7 10.4 1.8e-48 165.1 7.2 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE44662.1 - 7.2e-17 61.7 0.0 1.8e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 AAT PF03417.11 EFE44663.1 - 5.8e-44 150.2 0.0 7.1e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase NAAA-beta PF15508.1 EFE44663.1 - 0.00097 19.4 0.0 0.0026 18.0 0.0 1.8 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase 2OG-FeII_Oxy PF03171.15 EFE44664.1 - 1.3e-20 73.5 0.0 9.6e-20 70.7 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EFE44664.1 - 1.7e-12 47.8 0.0 2.7e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Glyco_hydro_20 PF00728.17 EFE44664.1 - 0.045 12.9 0.2 0.12 11.5 0.1 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain AMP-binding PF00501.23 EFE44665.1 - 1.7e-266 883.2 0.0 4.4e-98 328.4 0.0 3.3 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.15 EFE44665.1 - 9.2e-202 668.2 13.1 2.1e-76 256.6 0.6 4.4 4 0 0 4 4 4 4 Condensation domain PP-binding PF00550.20 EFE44665.1 - 1.5e-48 162.9 0.5 1.2e-15 57.5 0.0 4.1 3 0 0 3 3 3 3 Phosphopantetheine attachment site Thioesterase PF00975.15 EFE44665.1 - 7.5e-36 124.4 0.0 1.4e-35 123.6 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain AMP-binding_C PF13193.1 EFE44665.1 - 5.1e-34 117.0 0.0 2.3e-12 47.6 0.0 3.8 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain HxxPF_rpt PF13745.1 EFE44665.1 - 1.2e-25 89.6 0.4 8.1e-17 61.3 0.1 4.7 4 0 0 4 4 4 3 HxxPF-repeated domain Abhydrolase_6 PF12697.2 EFE44665.1 - 4.4e-06 26.7 0.1 1.6e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE44665.1 - 0.00081 19.1 0.0 0.0024 17.6 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ank_4 PF13637.1 EFE44667.1 - 0.00014 22.2 0.2 0.00047 20.6 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFE44667.1 - 0.00077 19.7 0.1 0.0027 18.0 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFE44667.1 - 0.0022 18.1 0.1 0.0059 16.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) GST_N_3 PF13417.1 EFE44668.1 - 5.4e-10 39.3 0.0 1.2e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFE44668.1 - 8.1e-10 38.7 0.0 1.5e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFE44668.1 - 3e-07 30.3 0.0 5e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 EFE44668.1 - 0.00025 21.4 0.0 0.0004 20.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFE44668.1 - 0.00053 19.9 0.0 0.00082 19.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFE44668.1 - 0.032 14.1 0.0 0.062 13.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ICL PF00463.16 EFE44671.1 - 6e-282 935.4 0.6 6.9e-282 935.2 0.4 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 EFE44671.1 - 1.9e-12 46.9 0.0 9.4e-12 44.6 0.0 2.0 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Trehalase PF01204.13 EFE44672.1 - 1.2e-194 647.6 0.0 1.5e-194 647.4 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 EFE44672.1 - 3.5e-17 61.4 0.1 5.6e-17 60.7 0.1 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain DUF4024 PF13216.1 EFE44672.1 - 0.03 14.1 0.3 0.054 13.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) RHH_4 PF13467.1 EFE44672.1 - 0.12 12.2 0.0 2.8 7.9 0.0 2.6 3 0 0 3 3 3 0 Ribbon-helix-helix domain adh_short PF00106.20 EFE44673.1 - 1.7e-25 89.8 0.0 2.8e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE44673.1 - 3e-18 66.4 0.0 7.2e-17 61.9 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE44673.1 - 3.1e-06 26.9 0.0 5e-06 26.3 0.0 1.4 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 EFE44673.1 - 0.1 11.6 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain OTU PF02338.14 EFE44674.1 - 4.7e-16 59.4 0.5 2e-15 57.4 0.0 2.2 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 EFE44674.1 - 5.7e-06 25.8 0.4 0.0086 15.4 0.0 2.7 2 1 1 3 3 3 2 Peptidase C65 Otubain DUF3275 PF11679.3 EFE44674.1 - 0.39 10.3 3.9 0.32 10.6 1.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) DUF4407 PF14362.1 EFE44674.1 - 0.62 8.9 12.5 1.1 8.1 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPMT PF05724.6 EFE44675.1 - 2.6e-16 59.7 0.5 2.2e-15 56.7 0.4 1.9 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_18 PF12847.2 EFE44675.1 - 3.4e-06 27.6 0.0 4.7e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE44675.1 - 5.9e-06 25.9 0.1 2.6e-05 23.8 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE44675.1 - 0.00014 22.3 0.0 0.00021 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE44675.1 - 0.00074 19.5 0.0 0.001 19.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE44675.1 - 0.0061 16.8 0.1 0.0087 16.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain N2227 PF07942.7 EFE44675.1 - 0.015 14.3 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 N2227-like protein TehB PF03848.9 EFE44675.1 - 0.036 13.2 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB AdoMet_MTase PF07757.8 EFE44675.1 - 0.077 13.1 0.5 0.16 12.1 0.4 1.8 1 1 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase MFS_1 PF07690.11 EFE44676.1 - 2.6e-46 157.9 42.9 3.2e-38 131.3 17.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE44676.1 - 6.3e-07 28.3 10.7 6.3e-07 28.3 7.4 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.15 EFE44676.1 - 0.016 13.2 10.6 1.1 7.2 0.0 3.6 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family DUF3295 PF11702.3 EFE44678.1 - 1.5e-120 403.6 46.0 1.5e-120 403.6 31.9 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF3295) DUF1752 PF08550.5 EFE44678.1 - 2.8e-06 26.8 5.4 7.2e-06 25.4 3.7 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ParBc PF02195.13 EFE44678.1 - 0.048 13.7 0.3 0.62 10.2 0.1 2.9 2 0 0 2 2 2 0 ParB-like nuclease domain FimP PF09766.4 EFE44678.1 - 0.88 8.5 21.3 1.9 7.4 6.0 3.0 3 0 0 3 3 3 0 Fms-interacting protein Polysacc_deac_1 PF01522.16 EFE44679.1 - 1.4e-22 79.5 0.0 1e-20 73.6 0.0 2.2 1 1 0 1 1 1 1 Polysaccharide deacetylase RWD PF05773.17 EFE44680.1 - 0.0083 16.0 0.1 0.67 9.8 0.0 2.5 2 0 0 2 2 2 1 RWD domain zf-DNA_Pol PF08996.5 EFE44680.1 - 0.046 13.0 6.1 1.5 8.1 0.3 2.3 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger DZR PF12773.2 EFE44680.1 - 6 6.7 7.8 5.3 6.9 1.2 2.6 2 1 0 2 2 2 0 Double zinc ribbon DUF1272 PF06906.6 EFE44680.1 - 7 6.5 7.1 0.37 10.6 0.6 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1272) zf-C3HC PF07967.8 EFE44682.1 - 8e-24 83.9 1.5 1e-20 73.8 0.2 3.3 2 1 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.5 EFE44682.1 - 4.4e-23 80.9 0.0 4.4e-23 80.9 0.0 2.3 2 1 1 3 3 3 1 Rsm1-like Pox_MCEL PF03291.11 EFE44683.1 - 1.6e-56 191.5 0.0 1.1e-52 178.9 0.0 3.8 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.7 EFE44683.1 - 1.4e-09 38.3 0.2 6.1e-08 33.0 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE44683.1 - 1.4e-07 31.8 0.0 0.041 14.3 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFE44683.1 - 3.4e-06 27.5 0.0 8.7e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE44683.1 - 2.2e-05 24.1 0.0 0.062 12.8 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.1 EFE44683.1 - 3.9e-05 23.4 0.0 0.00012 21.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE44683.1 - 0.00015 22.0 0.0 0.00071 19.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 EFE44683.1 - 0.0003 19.8 0.0 0.00054 19.0 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family DUF4551 PF15087.1 EFE44683.1 - 4.7 5.4 11.2 7.6 4.7 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) zf-Nse PF11789.3 EFE44684.1 - 2.6e-21 74.8 2.0 4.4e-21 74.1 1.4 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 EFE44684.1 - 3.9e-05 23.2 1.0 9e-05 22.1 0.2 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 EFE44684.1 - 5e-05 23.0 0.9 8.2e-05 22.3 0.6 1.4 1 0 0 1 1 1 1 Ring finger domain KRAB PF01352.22 EFE44684.1 - 0.027 13.9 0.2 0.05 13.0 0.1 1.4 1 0 0 1 1 1 0 KRAB box zf-MIZ PF02891.15 EFE44684.1 - 0.17 11.4 3.2 0.28 10.7 0.1 2.2 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Mito_carr PF00153.22 EFE44685.1 - 2.2e-53 177.9 3.4 3.6e-18 65.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tir_receptor_N PF07490.6 EFE44685.1 - 0.00027 20.6 1.2 0.00048 19.8 0.8 1.3 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) N-terminus DUF3611 PF12263.3 EFE44685.1 - 0.058 12.7 0.1 0.12 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) Arc_PepC_II PF06847.6 EFE44687.1 - 0.11 12.8 0.3 0.22 11.9 0.2 1.4 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II Copper-fist PF00649.13 EFE44688.1 - 2e-22 78.0 1.5 2e-22 78.0 1.1 2.5 2 1 1 3 3 3 1 Copper fist DNA binding domain Zn_clus PF00172.13 EFE44689.1 - 7.8e-11 41.6 9.6 1.2e-10 41.1 6.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4078 PF13300.1 EFE44689.1 - 0.032 14.3 0.0 0.032 14.3 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4078) Utp21 PF04192.7 EFE44690.1 - 1.5e-77 259.9 0.1 2.5e-77 259.1 0.0 1.4 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 EFE44690.1 - 7.5e-22 76.3 21.7 0.00034 20.3 0.2 9.6 11 0 0 11 11 11 6 WD domain, G-beta repeat Nup160 PF11715.3 EFE44690.1 - 0.011 13.9 0.6 0.49 8.4 0.7 2.6 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 EFE44690.1 - 0.14 10.4 0.0 0.24 9.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain RCR PF12273.3 EFE44691.1 - 0.48 10.9 2.4 1 9.9 1.6 1.9 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF383 PF04063.9 EFE44692.1 - 1.8e-43 148.3 8.5 3.4e-26 91.9 0.0 3.3 3 1 1 4 4 4 2 Domain of unknown function (DUF383) DUF384 PF04064.8 EFE44692.1 - 1.6e-21 75.6 0.9 5.1e-21 73.9 0.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF384) ArgJ PF01960.13 EFE44692.1 - 0.034 12.5 0.2 0.053 11.9 0.1 1.2 1 0 0 1 1 1 0 ArgJ family Rep-A_N PF04057.7 EFE44693.1 - 0.00045 19.9 0.0 0.00095 18.9 0.0 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain TPP1 PF10341.4 EFE44693.1 - 0.039 13.9 0.0 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Shelterin complex subunit, TPP1/ACD PAP_assoc PF03828.14 EFE44694.1 - 2e-08 34.0 0.0 6.4e-08 32.4 0.0 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase TFIIF_alpha PF05793.7 EFE44695.1 - 7.5e-06 24.5 75.2 0.00018 20.0 49.4 3.8 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) His_Phos_2 PF00328.17 EFE44697.1 - 3.5e-114 381.7 0.0 4.4e-114 381.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 EFE44697.1 - 4.7e-05 22.9 0.0 9.8e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Abhydrolase_2 PF02230.11 EFE44698.1 - 1.1e-21 77.3 0.0 5.4e-15 55.4 0.0 2.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EFE44698.1 - 8.9e-08 32.2 0.1 2e-06 27.8 0.1 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE44698.1 - 5.6e-07 29.4 0.0 8.5e-07 28.8 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 EFE44698.1 - 0.0032 16.9 0.0 0.013 14.9 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.16 EFE44698.1 - 0.012 14.8 0.0 0.029 13.5 0.0 1.4 1 1 0 1 1 1 0 Prolyl oligopeptidase family LIP PF03583.9 EFE44698.1 - 0.056 12.6 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 Secretory lipase APH PF01636.18 EFE44700.1 - 5.8e-08 32.7 0.0 1.1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE44700.1 - 0.009 15.5 0.0 0.042 13.4 0.0 1.9 2 0 0 2 2 2 1 Choline/ethanolamine kinase UCH PF00443.24 EFE44702.1 - 3.4e-63 213.2 0.1 5.5e-63 212.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFE44702.1 - 2.1e-33 116.0 0.6 3e-33 115.5 0.1 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RIG-I_C-RD PF11648.3 EFE44702.1 - 1.8 8.4 5.6 2.2 8.1 0.0 3.0 3 0 0 3 3 3 0 C-terminal domain of RIG-I DASH_Dam1 PF08653.5 EFE44703.1 - 1.2e-22 79.4 2.0 1.2e-22 79.4 1.4 1.6 2 0 0 2 2 2 1 DASH complex subunit Dam1 CRAL_TRIO PF00650.15 EFE44704.1 - 2.5e-38 131.0 0.0 6.3e-38 129.7 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFE44704.1 - 3.3e-14 52.7 0.0 1.1e-13 51.0 0.0 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EFE44704.1 - 5.6e-09 36.0 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF3142 PF11340.3 EFE44705.1 - 0.11 12.1 0.0 0.11 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) Peptidase_M20 PF01546.23 EFE44706.1 - 1.4e-21 76.8 0.2 1.9e-21 76.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFE44706.1 - 1.1e-05 25.1 0.0 2.8e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EFE44706.1 - 0.0015 18.2 0.0 0.0033 17.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 S10_plectin PF03501.10 EFE44707.1 - 2.9e-24 84.7 0.3 3.5e-24 84.4 0.2 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Telomere_Sde2 PF13019.1 EFE44708.1 - 2.7e-65 218.9 0.1 2.7e-65 218.9 0.0 1.4 2 0 0 2 2 2 1 Telomere stability and silencing MMR_HSR1 PF01926.18 EFE44709.1 - 4e-05 23.5 0.0 0.00027 20.8 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFE44709.1 - 0.024 13.9 0.1 4.5 6.5 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA PF00004.24 EFE44710.1 - 7.6e-37 126.4 0.0 1.3e-36 125.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 EFE44710.1 - 4.5e-10 39.2 0.1 9.3e-06 25.4 0.0 3.0 3 0 0 3 3 2 2 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 EFE44710.1 - 1.8e-05 24.8 0.1 0.00014 21.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EFE44710.1 - 9.7e-05 22.3 0.0 0.00017 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EFE44710.1 - 0.00013 21.1 0.0 0.00023 20.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EFE44710.1 - 0.00024 21.1 0.4 0.036 14.0 0.1 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EFE44710.1 - 0.0019 17.9 0.0 0.008 15.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 EFE44710.1 - 0.0029 17.0 0.0 0.0068 15.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 EFE44710.1 - 0.0034 16.1 0.0 0.0064 15.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.16 EFE44710.1 - 0.005 16.0 0.1 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 EFE44710.1 - 0.014 15.2 0.0 0.034 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EFE44710.1 - 0.02 14.6 2.0 0.023 14.4 0.0 2.1 3 0 0 3 3 1 0 Part of AAA domain AAA_17 PF13207.1 EFE44710.1 - 0.025 15.4 0.3 0.087 13.6 0.0 2.2 2 1 0 2 2 1 0 AAA domain AAA_25 PF13481.1 EFE44710.1 - 0.029 13.7 0.2 0.49 9.7 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.1 EFE44710.1 - 0.029 14.3 0.0 0.43 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 EFE44710.1 - 0.033 13.1 0.0 0.056 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 EFE44710.1 - 0.094 12.1 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.1 EFE44710.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFE44710.1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EFE44710.1 - 0.22 10.7 0.0 0.44 9.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Ribosomal_S17 PF00366.15 EFE44711.1 - 0.0032 17.4 0.5 0.0055 16.7 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 PNPOx_C PF10590.4 EFE44711.1 - 0.14 11.7 0.2 0.27 10.7 0.2 1.5 1 0 0 1 1 1 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region A_deaminase PF00962.17 EFE44712.1 - 1.4e-38 132.6 0.0 3.8e-37 127.9 0.0 2.5 3 0 0 3 3 3 1 Adenosine/AMP deaminase ATG2_CAD PF13329.1 EFE44713.1 - 1.1e-47 161.4 0.0 2.5e-47 160.3 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.6 EFE44713.1 - 8.1e-23 80.4 0.1 2.2e-22 79.0 0.1 1.8 1 0 0 1 1 1 1 ATG C terminal domain ketoacyl-synt PF00109.21 EFE44717.1 - 4.4e-72 242.5 0.0 9.3e-72 241.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.23 EFE44717.1 - 9.9e-68 228.4 0.0 7.8e-67 225.4 0.0 2.1 1 1 0 1 1 1 1 AMP-binding enzyme Acyl_transf_1 PF00698.16 EFE44717.1 - 4.3e-63 213.5 0.0 7.2e-63 212.8 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 EFE44717.1 - 7e-58 195.2 0.0 2.4e-57 193.5 0.0 2.0 1 0 0 1 1 1 1 KR domain PS-DH PF14765.1 EFE44717.1 - 3.6e-55 187.2 0.0 6e-55 186.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Condensation PF00668.15 EFE44717.1 - 2.7e-53 180.7 0.0 4.6e-53 180.0 0.0 1.4 1 0 0 1 1 1 1 Condensation domain adh_short PF00106.20 EFE44717.1 - 1.6e-46 158.2 0.5 5.2e-46 156.6 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFE44717.1 - 1.8e-40 137.5 0.2 1e-39 135.0 0.1 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.7 EFE44717.1 - 3.4e-36 124.4 0.0 8.5e-36 123.1 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein ADH_zinc_N PF00107.21 EFE44717.1 - 4.6e-21 74.7 0.0 1.6e-20 72.9 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 EFE44717.1 - 1e-20 73.7 0.3 8.7e-11 41.9 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.1 EFE44717.1 - 4.8e-12 46.8 0.0 9.5e-11 42.6 0.0 3.2 3 0 0 3 3 3 1 Zinc-binding dehydrogenase HxxPF_rpt PF13745.1 EFE44717.1 - 2.6e-11 43.6 0.0 8.8e-11 41.9 0.0 2.0 1 0 0 1 1 1 1 HxxPF-repeated domain Thiolase_N PF00108.18 EFE44717.1 - 0.007 15.3 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain DUF1233 PF06806.7 EFE44717.1 - 0.16 11.5 0.0 0.4 10.2 0.0 1.6 1 0 0 1 1 1 0 Putative excisionase (DUF1233) p450 PF00067.17 EFE44718.1 - 7.8e-52 176.3 0.0 1.3e-51 175.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 DUF2953 PF11167.3 EFE44718.1 - 0.11 12.4 0.1 0.31 10.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) Asp PF00026.18 EFE44719.1 - 2.6e-12 46.6 0.4 1.6e-08 34.2 0.0 2.2 2 1 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.1 EFE44719.1 - 0.0028 17.2 0.0 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Thioesterase PF00975.15 EFE44720.1 - 1.2e-20 74.7 0.1 1.8e-20 74.1 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 EFE44720.1 - 2.7e-08 33.9 0.0 3.6e-08 33.5 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE44720.1 - 2.2e-05 24.2 0.0 5.7e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE44720.1 - 0.002 17.7 0.0 0.003 17.1 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.8 EFE44720.1 - 0.038 13.5 0.0 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 PGAP1-like protein Pyr_redox PF00070.22 EFE44720.1 - 0.16 12.3 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFE44721.1 - 3.7e-20 72.2 0.1 7.4e-19 68.0 0.1 2.1 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.9 EFE44721.1 - 1.6e-07 30.3 1.2 2.3e-05 23.2 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.7 EFE44721.1 - 6.5e-06 25.3 0.0 1.1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 EFE44721.1 - 7.4e-06 26.1 0.0 2.8e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFE44721.1 - 0.00032 19.7 0.2 0.088 11.6 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE44721.1 - 0.0027 17.6 0.5 0.0085 16.1 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFE44721.1 - 0.02 15.2 0.0 0.06 13.7 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFE44721.1 - 0.025 14.4 0.3 0.055 13.3 0.2 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.13 EFE44722.1 - 8.9e-10 37.8 2.9 1.5e-09 37.1 2.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain CN_hydrolase PF00795.17 EFE44723.1 - 6.7e-30 103.8 0.0 9.7e-30 103.2 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Ribosomal_L31e PF01198.14 EFE44724.1 - 4.2e-31 106.4 1.5 5.3e-31 106.1 0.8 1.4 1 1 0 1 1 1 1 Ribosomal protein L31e Ran_BP1 PF00638.13 EFE44725.1 - 3.1e-13 49.8 0.0 7.3e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.1 EFE44725.1 - 0.0042 17.3 33.4 0.0042 17.3 23.2 10.3 3 3 5 8 8 8 3 Nucleoporin FG repeat region DUF3391 PF11871.3 EFE44725.1 - 0.21 11.8 1.2 0.79 9.9 0.9 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) SCP2 PF02036.12 EFE44726.1 - 3.3e-24 85.1 0.1 4.5e-24 84.6 0.1 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.1 EFE44726.1 - 0.0001 22.2 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.1 EFE44726.1 - 0.024 14.0 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 Sterol carrier protein domain F-box-like PF12937.2 EFE44727.1 - 0.0044 16.7 0.1 0.89 9.3 0.0 2.5 2 0 0 2 2 2 2 F-box-like SNF2_N PF00176.18 EFE44728.1 - 9.9e-70 234.6 0.5 1.7e-69 233.8 0.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFE44728.1 - 9.1e-11 41.4 0.0 2.6e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.1 EFE44728.1 - 6.5e-09 35.3 3.1 1.3e-08 34.3 2.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.24 EFE44728.1 - 2.9e-07 30.1 0.0 8.2e-07 28.6 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.1 EFE44728.1 - 1.4e-06 28.2 4.9 2.8e-06 27.2 3.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFE44728.1 - 5.3e-06 25.9 3.9 1.1e-05 24.9 2.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFE44728.1 - 7.1e-06 25.7 3.9 1.4e-05 24.7 2.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EFE44728.1 - 7.2e-05 22.4 3.8 0.00016 21.3 2.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.1 EFE44728.1 - 0.0016 17.9 3.0 0.0041 16.6 2.1 1.8 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 EFE44728.1 - 0.0037 17.1 5.8 0.008 16.0 4.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFE44728.1 - 0.036 13.7 1.1 0.081 12.6 0.7 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Arginosuc_synth PF00764.14 EFE44729.1 - 2.1e-80 270.6 0.0 1.2e-45 156.2 0.0 2.0 2 0 0 2 2 2 2 Arginosuccinate synthase MAD PF05557.8 EFE44730.1 - 3.8e-53 180.6 69.1 2e-43 148.5 47.9 2.2 2 0 0 2 2 2 2 Mitotic checkpoint protein Mto2_bdg PF12808.2 EFE44730.1 - 0.0051 16.9 4.6 0.0051 16.9 3.2 8.2 8 3 3 11 11 11 1 Micro-tubular organiser Mto1 C-term Mto2-binding region Bacillus_HBL PF05791.6 EFE44730.1 - 0.0072 15.7 5.6 0.0072 15.7 3.9 6.0 5 2 0 7 7 7 1 Bacillus haemolytic enterotoxin (HBL) Peptidase_M20 PF01546.23 EFE44731.1 - 6.8e-28 97.4 0.0 1.1e-27 96.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFE44731.1 - 2.9e-17 62.4 0.0 8.1e-17 60.9 0.0 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain muHD PF10291.4 EFE44732.1 - 8.5e-70 234.8 0.0 1.3e-69 234.3 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Laminin_II PF06009.7 EFE44732.1 - 0.0078 15.9 2.5 0.024 14.3 1.7 1.9 1 0 0 1 1 1 1 Laminin Domain II Muted PF14942.1 EFE44732.1 - 0.078 12.8 1.9 0.17 11.7 1.3 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Myosin_tail_1 PF01576.14 EFE44732.1 - 0.13 9.9 5.4 0.19 9.3 3.7 1.1 1 0 0 1 1 1 0 Myosin tail Spc7 PF08317.6 EFE44732.1 - 0.2 10.2 1.7 0.38 9.3 1.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIVA PF05103.8 EFE44732.1 - 0.27 11.2 3.9 0.74 9.8 2.7 1.7 1 0 0 1 1 1 0 DivIVA protein SH3_9 PF14604.1 EFE44733.1 - 7.6e-08 31.8 0.0 1.2e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFE44733.1 - 4.4e-06 25.9 0.0 6.8e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EFE44733.1 - 1.7e-05 24.2 0.0 2.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain IncA PF04156.9 EFE44733.1 - 0.013 15.0 0.3 0.043 13.4 0.0 1.8 2 0 0 2 2 2 0 IncA protein OPT PF03169.10 EFE44734.1 - 4.9e-158 527.3 20.6 5.7e-158 527.1 14.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4212 PF13937.1 EFE44734.1 - 0.029 14.3 10.1 0.79 9.7 0.2 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4212) Rav1p_C PF12234.3 EFE44735.1 - 1.1e-252 839.8 1.6 7.7e-241 800.6 0.6 2.2 1 1 1 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.27 EFE44735.1 - 0.00051 19.8 11.0 0.11 12.4 0.2 5.1 7 0 0 7 7 7 2 WD domain, G-beta repeat Ferritin_2 PF13668.1 EFE44736.1 - 1.7e-18 66.9 0.1 2.6e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain PilN PF05137.8 EFE44736.1 - 0.041 13.7 0.1 2.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Fimbrial assembly protein (PilN) Fungal_trans PF04082.13 EFE44737.1 - 1.8e-18 66.3 0.2 5.5e-18 64.7 0.2 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Spore_YpjB PF09577.5 EFE44737.1 - 0.029 13.9 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) SR-25 PF10500.4 EFE44738.1 - 0.17 11.3 3.5 0.21 11.0 2.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NST1 PF13945.1 EFE44738.1 - 0.23 11.5 2.7 0.23 11.4 1.9 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Arginosuc_synth PF00764.14 EFE44739.1 - 3.9e-25 88.6 0.1 4.5e-25 88.5 0.1 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 EFE44739.1 - 8.2e-06 25.5 0.0 9.3e-06 25.3 0.0 1.0 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 EFE44739.1 - 0.00017 20.9 0.0 0.00018 20.8 0.0 1.1 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 EFE44739.1 - 0.001 17.6 0.0 0.0012 17.4 0.0 1.3 1 1 0 1 1 1 1 tRNA methyl transferase DNA_pol3_gamma3 PF12169.3 EFE44739.1 - 0.0085 15.8 0.0 0.0089 15.7 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase III subunits gamma and tau domain III ATP_bind_3 PF01171.15 EFE44739.1 - 0.046 13.2 0.0 0.051 13.0 0.0 1.3 1 1 0 1 1 1 0 PP-loop family RasGEF PF00617.14 EFE44740.1 - 8.4e-39 133.2 0.2 1.3e-38 132.6 0.2 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EFE44740.1 - 6e-14 52.0 0.1 1.3e-13 50.9 0.1 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif Rotavirus_VP3 PF06929.6 EFE44740.1 - 0.49 8.2 0.0 0.82 7.4 0.0 1.2 1 0 0 1 1 1 0 Rotavirus VP3 protein NOA36 PF06524.7 EFE44740.1 - 6.7 5.8 4.3 11 5.1 3.0 1.2 1 0 0 1 1 1 0 NOA36 protein DIL PF01843.14 EFE44741.1 - 3e-18 65.6 3.9 1.4e-11 44.1 0.1 2.8 3 0 0 3 3 3 2 DIL domain Ank_2 PF12796.2 EFE44741.1 - 6.4e-18 64.8 0.3 3.7e-17 62.4 0.0 2.4 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFE44741.1 - 6.9e-15 54.0 0.1 1.1e-05 24.9 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 EFE44741.1 - 2.9e-11 43.2 0.1 5.5e-06 26.4 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE44741.1 - 1e-09 38.6 0.4 0.011 16.2 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE44741.1 - 1.6e-07 30.8 1.3 0.015 15.4 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat CDK2AP PF09806.4 EFE44742.1 - 0.7 10.0 7.5 0.73 10.0 5.2 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Gtr1_RagA PF04670.7 EFE44744.1 - 2.6e-71 239.4 1.0 3.4e-71 239.0 0.3 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Arf PF00025.16 EFE44744.1 - 4.5e-05 22.7 0.0 7.9e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 EFE44744.1 - 0.0011 19.4 0.0 0.0027 18.1 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 EFE44744.1 - 0.0014 17.8 0.0 0.0035 16.5 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Pkinase PF00069.20 EFE44745.1 - 1.9e-20 73.1 0.0 5.7e-20 71.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44745.1 - 0.058 12.4 0.0 0.093 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase His_Phos_2 PF00328.17 EFE44746.1 - 2.5e-21 76.3 0.0 1.3e-20 74.0 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Lactamase_B_2 PF12706.2 EFE44747.1 - 7.2e-31 107.2 0.1 1.4e-30 106.2 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 EFE44747.1 - 9.8e-26 89.0 0.2 9.9e-25 85.8 0.0 2.6 3 0 0 3 3 3 1 tRNase Z endonuclease Lactamase_B PF00753.22 EFE44747.1 - 4.2e-08 33.0 0.1 9.3e-08 31.9 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily NAD_binding_10 PF13460.1 EFE44748.1 - 4.7e-17 62.5 0.1 1.1e-16 61.3 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFE44748.1 - 0.00054 19.4 0.0 0.00087 18.7 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family LAM_C PF12544.3 EFE44748.1 - 0.054 13.5 0.1 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 Lysine-2,3-aminomutase Methyltransf_23 PF13489.1 EFE44749.1 - 2.7e-17 62.9 0.0 6.1e-15 55.3 0.0 2.8 1 1 2 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE44749.1 - 7.9e-17 61.2 0.0 8.9e-14 51.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFE44749.1 - 1.2e-15 58.0 0.0 7.3e-15 55.5 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE44749.1 - 1.4e-15 57.5 0.0 6.2e-14 52.2 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE44749.1 - 4.4e-14 52.6 0.1 1.4e-13 51.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE44749.1 - 1.5e-13 51.0 0.0 1.4e-09 38.2 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_26 PF13659.1 EFE44749.1 - 8.5e-09 35.4 0.0 3.4e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 EFE44749.1 - 1e-08 34.6 0.0 1.7e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.6 EFE44749.1 - 5e-06 26.0 0.0 0.00051 19.4 0.0 2.5 3 0 0 3 3 3 1 Nodulation protein S (NodS) MTS PF05175.9 EFE44749.1 - 2.8e-05 23.5 0.0 8.9e-05 21.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain MetW PF07021.7 EFE44749.1 - 0.00019 20.8 0.0 0.0022 17.4 0.0 2.0 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW TehB PF03848.9 EFE44749.1 - 0.00027 20.1 0.0 0.00046 19.4 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Pox_MCEL PF03291.11 EFE44749.1 - 0.00045 19.2 0.0 0.009 14.9 0.0 2.2 1 1 1 2 2 2 1 mRNA capping enzyme CheR PF01739.13 EFE44749.1 - 0.00072 18.8 0.1 0.83 8.9 0.0 2.5 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain TPMT PF05724.6 EFE44749.1 - 0.00088 18.7 0.0 0.0022 17.4 0.0 1.8 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_2 PF00891.13 EFE44749.1 - 0.0038 16.4 0.0 0.012 14.8 0.0 1.7 2 0 0 2 2 2 1 O-methyltransferase Ubie_methyltran PF01209.13 EFE44749.1 - 0.0053 15.8 0.0 0.025 13.7 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 EFE44749.1 - 0.0065 15.2 0.0 0.011 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.14 EFE44749.1 - 0.013 15.0 0.0 0.034 13.6 0.0 1.7 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0146 PF03686.8 EFE44749.1 - 0.027 14.3 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) FmrO PF07091.6 EFE44749.1 - 0.032 13.2 0.0 0.049 12.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_32 PF13679.1 EFE44749.1 - 0.047 13.3 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain bZIP_1 PF00170.16 EFE44751.1 - 3.8e-10 39.5 9.3 3.8e-10 39.5 6.4 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 EFE44751.1 - 4.2e-05 23.2 10.9 4.2e-05 23.2 7.6 2.7 2 0 0 2 2 2 1 Basic region leucine zipper Dus PF01207.12 EFE44752.1 - 2.8e-58 197.1 0.0 6.6e-58 195.9 0.0 1.5 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 EFE44752.1 - 0.097 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase APH PF01636.18 EFE44753.1 - 1.6e-07 31.3 0.1 5.6e-07 29.5 0.0 1.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE44753.1 - 0.00095 17.9 0.0 0.053 12.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.15 EFE44753.1 - 0.0067 15.6 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.15 EFE44753.1 - 0.13 11.8 0.1 0.31 10.5 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase CENP-X PF09415.5 EFE44755.1 - 1.5e-13 50.3 0.6 3.2e-13 49.2 0.4 1.6 1 0 0 1 1 1 1 CENP-S associating Centromere protein X Paramyxo_ncap PF00973.14 EFE44755.1 - 1 8.0 5.0 1.3 7.6 3.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Mis12 PF05859.7 EFE44756.1 - 9.3e-45 151.9 0.0 1.5e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Mis12 protein Trans_reg_C PF00486.23 EFE44757.1 - 0.024 14.5 0.6 0.087 12.7 0.2 2.0 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal DUF373 PF04123.8 EFE44758.1 - 0.099 11.6 0.6 0.12 11.3 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF2484 PF10658.4 EFE44758.1 - 0.22 11.6 2.5 2.6 8.2 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2484) Claudin_2 PF13903.1 EFE44758.1 - 0.34 10.5 10.7 0.068 12.8 3.4 2.4 1 1 2 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction TctB PF07331.6 EFE44758.1 - 1.1 8.8 6.4 0.31 10.6 0.7 2.4 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family BCNT PF07572.7 EFE44759.1 - 9.5e-29 99.1 1.7 2.8e-28 97.6 1.1 1.9 1 0 0 1 1 1 1 Bucentaur or craniofacial development Acetyltransf_3 PF13302.1 EFE44760.1 - 2.8e-33 115.0 0.0 3.3e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFE44760.1 - 0.0011 18.8 0.1 0.051 13.4 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFE44760.1 - 0.039 13.9 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Methyltransf_3 PF01596.12 EFE44761.1 - 1.2e-34 119.1 0.0 1.8e-34 118.5 0.0 1.3 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 EFE44761.1 - 7.2e-11 42.8 0.0 1.8e-10 41.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EFE44761.1 - 1.5e-10 41.0 0.0 2.1e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 EFE44761.1 - 4.7e-09 36.8 0.0 7.8e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE44761.1 - 8.5e-09 35.1 0.0 1.3e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE44761.1 - 2.2e-05 24.4 0.0 3.3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFE44761.1 - 0.00049 19.2 0.0 0.00066 18.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFE44761.1 - 0.0079 16.6 0.0 0.018 15.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE44761.1 - 0.011 16.2 0.0 0.061 13.8 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 EFE44761.1 - 0.011 14.7 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_25 PF13649.1 EFE44761.1 - 0.018 15.4 0.0 0.027 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.5 EFE44761.1 - 0.029 13.8 0.0 0.038 13.4 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_15 PF09445.5 EFE44761.1 - 0.083 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MTS PF05175.9 EFE44761.1 - 0.17 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Spt20 PF12090.3 EFE44762.1 - 7.9e-47 158.9 0.1 7.9e-47 158.9 0.0 5.3 3 2 0 3 3 3 1 Spt20 family Lipase_GDSL_2 PF13472.1 EFE44763.1 - 1.6e-10 41.4 0.0 1.4e-08 35.1 0.0 2.3 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFE44763.1 - 1.1e-05 25.4 0.0 0.00034 20.5 0.0 3.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF1743 PF08489.6 EFE44763.1 - 0.065 12.9 0.0 0.2 11.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1743) Reprolysin_4 PF13583.1 EFE44764.1 - 0.011 15.3 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.19 EFE44764.1 - 0.012 15.0 1.2 0.18 11.1 0.2 2.6 3 0 0 3 3 3 0 Astacin (Peptidase family M12A) Reprolysin_2 PF13574.1 EFE44764.1 - 0.017 15.2 0.0 0.031 14.3 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 EFE44764.1 - 0.083 13.4 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 EFE44764.1 - 0.16 11.7 2.4 0.21 11.3 0.9 2.0 2 1 0 2 2 2 0 Matrixin Reprolysin_5 PF13688.1 EFE44764.1 - 0.2 11.5 0.6 0.37 10.6 0.4 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Glyco_hydro_18 PF00704.23 EFE44765.1 - 4.8e-58 197.2 0.0 6.2e-58 196.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.8 EFE44765.1 - 0.038 13.1 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 LysM PF01476.15 EFE44766.1 - 1.8e-09 37.3 0.0 1e-05 25.2 0.0 2.4 2 0 0 2 2 2 2 LysM domain CheB_methylest PF01339.12 EFE44767.1 - 0.046 13.1 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 CheB methylesterase Hexapep PF00132.19 EFE44769.1 - 4.9e-07 28.9 2.7 0.0019 17.6 0.1 3.4 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.18 EFE44769.1 - 0.00086 18.6 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 EFE44769.1 - 0.043 13.8 0.0 0.091 12.8 0.0 1.6 1 0 0 1 1 1 0 MobA-like NTP transferase domain Fucokinase PF07959.7 EFE44769.1 - 0.095 11.2 0.1 0.15 10.6 0.1 1.2 1 0 0 1 1 1 0 L-fucokinase DUF3530 PF12048.3 EFE44771.1 - 4.5 6.1 7.3 5 6.0 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Serglycin PF04360.7 EFE44772.1 - 1.1 9.0 9.1 0.043 13.5 1.1 2.5 3 0 0 3 3 3 0 Serglycin Peptidase_S64 PF08192.6 EFE44773.1 - 0.0031 15.9 0.0 0.0064 14.8 0.0 1.4 2 0 0 2 2 2 1 Peptidase family S64 Ribosomal_L11_N PF03946.9 EFE44775.1 - 0.0035 16.7 0.5 0.011 15.2 0.4 1.8 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain ELO PF01151.13 EFE44776.1 - 1.1e-84 283.6 3.8 1.6e-84 283.0 2.7 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Ycf1 PF05758.7 EFE44776.1 - 0.001 16.9 0.8 0.001 16.9 0.6 2.4 2 0 0 2 2 2 1 Ycf1 CDC45 PF02724.9 EFE44776.1 - 0.0024 16.0 2.2 0.0024 16.0 1.5 2.0 2 0 0 2 2 2 1 CDC45-like protein TRAP_alpha PF03896.11 EFE44776.1 - 1.5 7.7 10.4 0.14 11.1 0.2 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PBP1_TM PF14812.1 EFE44776.1 - 6.6 7.1 19.7 2.8 8.3 10.5 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2413 PF10310.4 EFE44777.1 - 0.14 10.9 1.5 0.18 10.5 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Fungal_trans_2 PF11951.3 EFE44778.1 - 1e-05 24.3 7.3 1.7e-05 23.6 5.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain APH PF01636.18 EFE44781.1 - 8.4e-17 61.6 0.2 1.5e-16 60.8 0.1 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE44781.1 - 4.2e-05 23.2 0.1 8.3e-05 22.2 0.1 1.4 2 0 0 2 2 2 1 Choline/ethanolamine kinase NADHdh_A3 PF14987.1 EFE44782.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 BNR PF02012.15 EFE44783.1 - 0.089 12.6 0.2 0.089 12.6 0.1 2.9 3 0 0 3 3 3 0 BNR/Asp-box repeat TruD PF01142.13 EFE44784.1 - 1.5e-50 171.9 0.0 6.2e-46 156.7 0.0 4.4 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Cupin_1 PF00190.17 EFE44785.1 - 1.1e-26 93.0 0.0 4.8e-12 45.5 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.6 EFE44785.1 - 1.7e-20 72.3 1.1 1.5e-09 37.2 0.0 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 EFE44785.1 - 7.6e-07 28.4 0.1 0.0028 17.0 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.14 EFE44785.1 - 0.00018 21.1 1.2 0.013 15.1 0.2 2.4 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_6 PF12852.2 EFE44785.1 - 0.039 13.5 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 0 Cupin 3-HAO PF06052.7 EFE44785.1 - 0.094 12.1 0.0 0.45 9.9 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase RPE65 PF03055.10 EFE44788.1 - 3.6e-119 398.5 0.0 4.1e-119 398.3 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF2293 PF10056.4 EFE44789.1 - 2.2e-29 101.2 0.2 4.6e-29 100.2 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) DUF3887 PF13026.1 EFE44789.1 - 0.09 13.0 0.2 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3887) DUF2823 PF11034.3 EFE44789.1 - 0.33 11.0 3.2 1.2 9.3 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2823) Mtc PF03820.12 EFE44791.1 - 1.6e-99 332.4 0.4 6.5e-96 320.6 0.3 3.0 1 1 0 1 1 1 1 Tricarboxylate carrier TFIIA PF03153.8 EFE44792.1 - 0.00029 20.8 1.9 0.00033 20.6 1.3 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Afi1 PF07792.7 EFE44792.1 - 0.56 10.2 4.6 0.57 10.1 0.6 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF3449 PF11931.3 EFE44792.1 - 0.56 9.6 7.0 1.1 8.7 4.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3449) CENP-B_dimeris PF09026.5 EFE44792.1 - 0.73 10.1 13.0 1.3 9.3 9.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.1 EFE44792.1 - 0.89 9.2 7.3 1.3 8.7 2.2 2.1 2 0 0 2 2 2 0 FAM176 family RNA_pol_3_Rpc31 PF11705.3 EFE44792.1 - 6 6.7 14.7 0.12 12.2 4.5 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Pkinase PF00069.20 EFE44793.1 - 4.5e-55 186.5 0.0 9.2e-55 185.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44793.1 - 7.4e-20 71.1 0.0 2.7e-19 69.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase BBE PF08031.7 EFE44794.1 - 7.7e-15 54.5 0.1 2.4e-14 52.9 0.0 1.9 2 0 0 2 2 2 1 Berberine and berberine like FAD_binding_4 PF01565.18 EFE44794.1 - 7.7e-12 44.8 0.1 2e-11 43.4 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain CPSF73-100_C PF11718.3 EFE44795.1 - 2.8e-62 209.8 0.0 6.5e-60 202.1 0.0 2.7 2 1 0 2 2 2 2 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 EFE44795.1 - 5.8e-33 113.5 0.0 1.4e-32 112.3 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 EFE44795.1 - 4.7e-07 29.6 0.0 8.6e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.7 EFE44795.1 - 8e-07 28.7 0.2 1.6e-06 27.8 0.2 1.5 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_2 PF12706.2 EFE44795.1 - 2.7e-05 23.8 1.4 3.9e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain TAF4 PF05236.9 EFE44796.1 - 7.9e-15 54.8 8.1 1e-08 34.7 6.0 3.4 2 1 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family Kdo PF06293.9 EFE44797.1 - 1.8e-07 30.4 0.1 4.3e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MAP7 PF05672.6 EFE44797.1 - 0.00021 20.7 33.1 0.00041 19.7 22.9 1.4 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family APH PF01636.18 EFE44797.1 - 0.023 14.4 0.1 0.023 14.4 0.1 3.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family ARGLU PF15346.1 EFE44797.1 - 0.054 13.2 34.4 0.13 12.0 23.8 1.5 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Spore_coat_CotO PF14153.1 EFE44797.1 - 0.7 9.3 10.8 1.4 8.3 7.5 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Ycf1 PF05758.7 EFE44797.1 - 0.92 7.1 5.3 1.3 6.6 3.7 1.1 1 0 0 1 1 1 0 Ycf1 Asp-B-Hydro_N PF05279.6 EFE44797.1 - 5.5 6.7 14.5 11 5.7 10.0 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BTV_NS2 PF04514.7 EFE44797.1 - 6.6 5.5 9.9 12 4.6 6.9 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Peptidase_S41 PF03572.13 EFE44798.1 - 4.2e-06 26.2 0.0 2e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Peptidase family S41 Transferase PF02458.10 EFE44799.1 - 1.8e-30 105.7 0.0 3e-13 49.0 0.0 3.1 3 0 0 3 3 3 3 Transferase family PGG PF13962.1 EFE44802.1 - 0.013 15.1 0.1 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function Cyclin_N PF00134.18 EFE44803.1 - 1.1e-15 57.2 0.1 2.2e-15 56.3 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFE44803.1 - 1.1e-06 28.6 0.1 0.0001 22.2 0.0 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.14 EFE44803.1 - 0.0047 16.7 2.0 0.085 12.6 0.0 2.4 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Prothymosin PF03247.9 EFE44803.1 - 7.1 6.8 22.2 3.1 7.9 9.1 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family EAF PF09816.4 EFE44804.1 - 2.6e-18 65.9 1.4 5.9e-18 64.8 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor SSP160 PF06933.6 EFE44804.1 - 2.9 5.7 15.3 5.4 4.8 10.6 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dor1 PF04124.7 EFE44805.1 - 7.5e-54 182.4 3.8 6.3e-45 153.0 1.2 2.5 1 1 1 2 2 2 2 Dor1-like family Vps51 PF08700.6 EFE44805.1 - 0.022 14.5 2.1 0.05 13.4 0.2 2.4 2 0 0 2 2 2 0 Vps51/Vps67 RIC1 PF07064.8 EFE44805.1 - 0.03 13.7 0.1 0.067 12.6 0.1 1.6 1 0 0 1 1 1 0 RIC1 Snf7 PF03357.16 EFE44805.1 - 0.062 12.6 0.7 0.18 11.1 0.5 1.8 1 0 0 1 1 1 0 Snf7 ApoLp-III PF07464.6 EFE44805.1 - 0.097 12.6 0.5 4.1 7.4 0.2 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Sec8_exocyst PF04048.9 EFE44805.1 - 0.1 12.2 2.1 0.16 11.5 0.6 2.0 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain COG5 PF10392.4 EFE44805.1 - 1.1 9.2 10.7 12 5.8 3.3 3.8 3 1 0 3 3 3 0 Golgi transport complex subunit 5 His_Phos_1 PF00300.17 EFE44806.1 - 1.2e-27 96.9 0.0 2.8e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 EFE44806.1 - 1.2e-05 24.8 0.0 2.2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Nucleoplasmin PF03066.10 EFE44806.1 - 5.3 6.5 11.9 8.4 5.8 1.3 2.2 2 0 0 2 2 2 0 Nucleoplasmin Abhydrolase_6 PF12697.2 EFE44808.1 - 5.7e-13 49.2 0.0 9.2e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE44808.1 - 2.1e-07 30.8 0.0 3.2e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFE44808.1 - 0.00062 19.3 0.1 0.0034 16.9 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFE44808.1 - 0.013 14.7 0.2 3.3 6.8 0.0 2.5 2 1 0 2 2 2 0 Prolyl oligopeptidase family Pex14_N PF04695.8 EFE44809.1 - 2.6 8.0 8.6 0.17 11.8 1.0 2.3 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cyclin PF08613.6 EFE44811.1 - 1.5e-13 51.4 0.0 2.5e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin DUF4557 PF15101.1 EFE44811.1 - 0.27 11.0 8.4 0.5 10.1 5.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Caps_synth_GfcC PF06251.6 EFE44811.1 - 0.35 9.9 8.5 0.6 9.2 5.9 1.3 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Suf PF05843.9 EFE44811.1 - 0.48 10.0 5.4 0.17 11.5 1.9 1.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Peptidase_S49_N PF08496.5 EFE44811.1 - 0.62 9.8 4.8 1 9.1 3.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FUSC PF04632.7 EFE44811.1 - 0.78 8.1 5.9 0.035 12.5 0.4 1.3 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF4175 PF13779.1 EFE44811.1 - 1.2 6.7 15.8 1.9 6.0 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4449 PF14613.1 EFE44812.1 - 0.77 9.6 12.1 0.89 9.4 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) FLO_LFY PF01698.11 EFE44812.1 - 0.94 8.2 16.2 1.1 8.0 11.2 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF1510 PF07423.6 EFE44812.1 - 1.3 8.3 21.3 1.6 8.0 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RNA_polI_A34 PF08208.6 EFE44812.1 - 1.3 8.6 35.7 1.7 8.2 24.7 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Spt5_N PF11942.3 EFE44812.1 - 1.3 9.6 20.4 2.2 8.9 14.2 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal GAGA_bind PF06217.7 EFE44812.1 - 2.1 8.2 16.2 2.3 8.1 11.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF1168 PF06658.7 EFE44812.1 - 2.3 7.7 32.3 3 7.3 22.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) PRP38_assoc PF12871.2 EFE44812.1 - 2.3 8.7 24.3 3.1 8.4 16.9 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3807 PF12720.2 EFE44812.1 - 2.6 8.1 18.7 3 7.9 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) GKAP PF03359.8 EFE44812.1 - 2.8 7.4 19.4 3.2 7.2 13.5 1.0 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein Nop53 PF07767.6 EFE44812.1 - 2.8 6.8 29.1 3.7 6.4 20.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.9 EFE44812.1 - 3.1 5.7 20.6 3.4 5.6 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.8 EFE44812.1 - 3.1 6.4 22.3 3.4 6.2 15.4 1.0 1 0 0 1 1 1 0 Paf1 MIP-T3 PF10243.4 EFE44812.1 - 3.4 6.0 33.4 3.8 5.8 23.1 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 eIF3_subunit PF08597.5 EFE44812.1 - 5.1 6.5 25.8 6.3 6.2 17.9 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Apt1 PF10351.4 EFE44812.1 - 7.6 5.2 12.2 8.4 5.1 8.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Daxx PF03344.10 EFE44812.1 - 7.7 4.8 18.3 8.8 4.6 12.7 1.0 1 0 0 1 1 1 0 Daxx Family ISG65-75 PF11727.3 EFE44812.1 - 8.1 5.4 18.0 9.2 5.2 12.5 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein TEX19 PF15553.1 EFE44812.1 - 8.3 6.2 7.1 9.6 6.0 4.9 1.1 1 0 0 1 1 1 0 Testis-expressed protein 19 Rtf2 PF04641.7 EFE44812.1 - 9.1 5.3 20.3 14 4.7 14.1 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger TATR PF03430.8 EFE44812.1 - 9.6 4.7 15.9 10 4.6 11.0 1.0 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Mem_trans PF03547.13 EFE44812.1 - 9.8 4.3 6.1 11 4.2 4.2 1.0 1 0 0 1 1 1 0 Membrane transport protein Vfa1 PF08432.5 EFE44812.1 - 9.8 6.1 23.4 14 5.6 16.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CRC_subunit PF08624.5 EFE44813.1 - 7e-57 191.2 0.1 1e-56 190.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit APH PF01636.18 EFE44815.1 - 8.2e-05 22.4 0.3 0.0005 19.8 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFE44815.1 - 0.12 11.0 0.0 0.39 9.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Beta-lactamase PF00144.19 EFE44816.1 - 3e-22 79.0 0.1 4.3e-22 78.5 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S58 PF03576.9 EFE44818.1 - 2.9e-86 289.6 4.6 3e-68 230.4 0.5 2.0 1 1 1 2 2 2 2 Peptidase family S58 Pkinase PF00069.20 EFE44819.1 - 4.2e-29 101.4 0.0 1e-28 100.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44819.1 - 7.3e-15 54.7 0.0 1.7e-14 53.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase PrgH PF09480.5 EFE44819.1 - 0.05 12.4 0.3 0.069 11.9 0.2 1.2 1 0 0 1 1 1 0 Type III secretion system protein PrgH-EprH (PrgH) Connexin43 PF03508.8 EFE44819.1 - 2.9 7.2 3.9 5.4 6.3 2.7 1.3 1 0 0 1 1 1 0 Gap junction alpha-1 protein (Cx43) DUF1344 PF07076.6 EFE44820.1 - 0.05 13.1 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) FecR PF04773.8 EFE44820.1 - 0.08 13.1 0.6 0.48 10.6 0.1 2.6 2 1 0 2 2 2 0 FecR protein FAD_binding_4 PF01565.18 EFE44821.1 - 5.2e-21 74.5 0.0 9.6e-21 73.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain p450 PF00067.17 EFE44822.1 - 3.1e-44 151.2 0.0 4.6e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Terpene_synth_C PF03936.11 EFE44823.1 - 1.3e-08 34.3 0.6 2.2e-05 23.8 0.2 2.7 2 1 0 2 2 2 2 Terpene synthase family, metal binding domain Prenyltrans_1 PF13243.1 EFE44823.1 - 6.7e-08 32.5 0.0 0.0073 16.3 0.0 3.3 2 1 1 3 3 3 3 Prenyltransferase-like Prenyltrans_2 PF13249.1 EFE44823.1 - 1.5e-07 31.8 0.1 0.017 15.4 0.0 4.1 2 1 2 4 4 4 2 Prenyltransferase-like Prenyltrans PF00432.16 EFE44823.1 - 0.024 14.2 0.0 6 6.5 0.0 3.0 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat p450 PF00067.17 EFE44824.1 - 2e-32 112.3 0.0 3.4e-16 58.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.17 EFE44825.1 - 1.5e-40 139.1 0.0 2.1e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Na_Ca_ex PF01699.19 EFE44826.1 - 4.8e-27 94.2 30.3 1.8e-13 50.3 10.4 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein TM_helix PF05552.7 EFE44826.1 - 0.45 10.2 5.4 2 8.1 3.8 2.1 1 0 0 1 1 1 0 Conserved TM helix IncA PF04156.9 EFE44826.1 - 0.81 9.2 0.0 0.81 9.2 0.0 2.4 3 0 0 3 3 3 0 IncA protein p450 PF00067.17 EFE44827.1 - 1e-26 93.5 0.0 1.6e-18 66.4 0.0 3.0 1 1 2 3 3 3 3 Cytochrome P450 ADH_zinc_N_2 PF13602.1 EFE44829.1 - 1.2e-12 48.8 0.0 4.3e-12 47.0 0.0 1.9 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFE44829.1 - 7.6e-10 38.5 0.0 1.3e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFE44829.1 - 3.3e-06 26.6 0.0 9.3e-06 25.2 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase YjeF_N PF03853.10 EFE44829.1 - 0.062 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus DIOX_N PF14226.1 EFE44830.1 - 3.5e-23 82.3 0.0 7.6e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFE44830.1 - 1.2e-11 44.8 0.1 2.6e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Asp_Glu_race PF01177.17 EFE44831.1 - 3.8e-23 82.5 0.7 4.6e-23 82.2 0.5 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase AroM PF07302.6 EFE44831.1 - 0.0031 16.8 0.0 0.57 9.4 0.0 2.3 1 1 1 2 2 2 2 AroM protein Pantoate_transf PF02548.10 EFE44831.1 - 0.05 12.7 0.4 1.4 7.9 0.0 2.1 1 1 1 2 2 2 0 Ketopantoate hydroxymethyltransferase MFS_1 PF07690.11 EFE44832.1 - 1.4e-38 132.5 24.7 2.1e-33 115.5 12.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 EFE44832.1 - 0.014 13.5 3.0 0.2 9.6 0.1 2.4 1 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DIOX_N PF14226.1 EFE44834.1 - 5.8e-20 71.9 0.0 9.9e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFE44834.1 - 1.2e-13 51.1 0.0 2.3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ketoacyl-synt PF00109.21 EFE44835.1 - 5.2e-74 248.9 0.0 1e-73 247.9 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFE44835.1 - 3.4e-41 141.6 0.5 2.9e-40 138.5 0.0 2.6 2 1 1 3 3 3 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 EFE44835.1 - 2.2e-32 111.3 0.6 2.2e-32 111.3 0.4 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFE44835.1 - 2.3e-13 50.1 0.1 6.5e-13 48.7 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 EFE44835.1 - 6.6e-05 22.0 0.0 0.00013 21.0 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Trp_DMAT PF11991.3 EFE44836.1 - 6.1e-78 262.5 0.0 7.4e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Orexin PF02072.10 EFE44836.1 - 0.0032 17.2 0.0 0.0057 16.4 0.0 1.3 1 0 0 1 1 1 1 Prepro-orexin DUF4060 PF13269.1 EFE44836.1 - 0.14 12.0 0.1 6.5 6.7 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4060) FAD_binding_3 PF01494.14 EFE44837.1 - 6.6e-12 45.1 1.8 7e-06 25.3 0.2 2.9 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.19 EFE44837.1 - 0.0052 15.7 0.1 0.022 13.6 0.0 1.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFE44837.1 - 0.0068 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EFE44837.1 - 0.022 13.8 0.0 2.8 6.8 0.0 2.3 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Thi4 PF01946.12 EFE44837.1 - 0.053 12.6 0.0 0.092 11.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DUF871 PF05913.6 EFE44837.1 - 0.094 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF871) Pyr_redox_2 PF07992.9 EFE44837.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lactamase_B PF00753.22 EFE44838.1 - 4.6e-19 68.8 0.5 1.3e-18 67.3 0.3 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFE44838.1 - 9.7e-05 21.9 0.1 0.00018 21.1 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EFE44838.1 - 0.033 13.9 0.0 0.087 12.5 0.0 1.6 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Fungal_trans PF04082.13 EFE44839.1 - 3.1e-10 39.3 0.1 4.7e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFE44839.1 - 1.1e-07 31.6 7.1 2.1e-07 30.7 4.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Metallophos PF00149.23 EFE44840.1 - 9.6e-10 38.1 1.8 6.3e-07 28.9 0.3 3.0 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase Tyrosinase PF00264.15 EFE44841.1 - 1.8e-51 175.4 6.8 1.9e-51 175.3 2.3 2.1 2 0 0 2 2 2 1 Common central domain of tyrosinase Fungal_trans PF04082.13 EFE44842.1 - 2.9e-23 82.0 1.5 4.3e-23 81.5 1.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_S8e PF01201.17 EFE44843.1 - 4.6e-28 97.9 1.6 8.7e-28 97.0 1.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e RIB43A PF05914.7 EFE44844.1 - 0.006 15.2 0.9 0.0095 14.6 0.6 1.2 1 0 0 1 1 1 1 RIB43A Pkinase PF00069.20 EFE44845.1 - 1.2e-48 165.4 0.0 1.8e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44845.1 - 6.4e-18 64.7 0.0 1e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 EFE44845.1 - 0.00014 21.2 0.2 0.00039 19.8 0.1 1.8 1 1 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 EFE44845.1 - 0.00041 19.4 0.0 0.00064 18.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFE44845.1 - 0.0023 17.7 0.0 0.34 10.5 0.0 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFE44845.1 - 0.072 12.1 0.1 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PWI PF01480.12 EFE44846.1 - 4.1e-24 84.4 0.1 7.5e-24 83.6 0.0 1.5 1 0 0 1 1 1 1 PWI domain PepSY_TM_3 PF13706.1 EFE44847.1 - 0.0022 17.3 0.5 0.0042 16.4 0.3 1.4 1 0 0 1 1 1 1 PepSY-associated TM helix DUF3042 PF11240.3 EFE44847.1 - 0.15 11.9 1.4 0.96 9.2 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) CFEM PF05730.6 EFE44847.1 - 0.71 9.7 7.5 0.23 11.3 3.0 1.8 2 0 0 2 2 2 0 CFEM domain FAA_hydrolase PF01557.13 EFE44848.1 - 4.8e-52 176.5 0.0 7e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family HTH_1 PF00126.22 EFE44849.1 - 0.017 14.8 0.4 0.1 12.3 0.2 2.3 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Baculo_PEP_C PF04513.7 EFE44849.1 - 0.06 13.1 1.6 0.15 11.9 0.9 1.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF883 PF05957.8 EFE44849.1 - 0.43 10.9 4.1 1.6 9.1 2.8 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DEAD PF00270.24 EFE44850.1 - 3e-43 147.2 1.9 4e-43 146.8 0.7 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE44850.1 - 1.6e-27 95.1 0.2 4.7e-27 93.6 0.2 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFE44850.1 - 0.00078 19.3 0.1 0.002 17.9 0.1 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EFE44850.1 - 0.0025 17.4 0.5 0.0067 16.0 0.2 1.8 2 1 0 2 2 2 1 AAA domain CMS1 PF14617.1 EFE44850.1 - 0.012 14.7 0.0 0.026 13.5 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.1 EFE44850.1 - 0.018 14.7 0.1 0.05 13.3 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 EFE44850.1 - 0.026 14.6 0.1 0.087 12.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.9 EFE44850.1 - 0.036 13.6 0.1 0.25 10.9 0.0 2.1 2 0 0 2 2 2 0 Helicase SNF2_N PF00176.18 EFE44850.1 - 0.075 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain Pkinase PF00069.20 EFE44851.1 - 5e-63 212.6 0.0 7.3e-63 212.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44851.1 - 3.9e-26 91.6 0.0 5.6e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFE44851.1 - 0.02 13.9 0.0 0.041 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFE44851.1 - 0.026 13.4 0.0 0.11 11.4 0.0 1.6 1 1 0 2 2 2 0 Kinase-like Pkinase PF00069.20 EFE44852.1 - 3.8e-59 199.9 0.0 6.9e-59 199.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44852.1 - 7.8e-35 120.1 0.0 8e-33 113.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFE44852.1 - 1.1e-09 37.7 0.0 7.3e-08 31.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 EFE44852.1 - 0.0047 16.6 0.1 0.01 15.5 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF2263 PF10021.4 EFE44853.1 - 2.9e-05 24.1 0.0 0.00011 22.2 0.0 1.9 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Methyltransf_23 PF13489.1 EFE44854.1 - 6.2e-14 52.0 0.0 4.9e-13 49.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE44854.1 - 2.6e-09 37.6 0.0 1.1e-08 35.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE44854.1 - 2.9e-08 33.4 0.0 4.9e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE44854.1 - 1.7e-05 25.1 0.0 5.9e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE44854.1 - 0.0007 20.0 0.0 0.0015 18.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFE44854.1 - 0.0014 18.6 0.0 0.027 14.4 0.0 2.2 2 0 0 2 2 2 1 FtsJ-like methyltransferase MTS PF05175.9 EFE44854.1 - 0.0045 16.3 0.0 0.031 13.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 EFE44854.1 - 0.0069 15.4 0.0 0.016 14.3 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_25 PF13649.1 EFE44854.1 - 0.032 14.6 0.0 0.1 12.9 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.7 EFE44854.1 - 0.056 12.9 0.0 0.088 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) NADHdh-2_N PF12155.3 EFE44854.1 - 0.13 12.3 0.2 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 N-terminal Scramblase PF03803.10 EFE44855.1 - 7.9e-50 168.9 0.0 1.9e-46 157.9 0.0 3.6 2 1 0 2 2 2 2 Scramblase Ribosomal_L27 PF01016.14 EFE44856.1 - 2.9e-31 107.0 0.9 5.2e-31 106.2 0.6 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein Rad9_Rad53_bind PF08605.5 EFE44857.1 - 1.8e-17 63.3 0.0 3.2e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.21 EFE44857.1 - 1.6e-07 31.3 0.0 1.2e-06 28.5 0.0 2.5 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain tRNA_int_endo PF01974.12 EFE44858.1 - 2.9e-19 68.6 0.1 5.6e-19 67.7 0.1 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 EFE44858.1 - 2e-05 24.0 0.0 0.00059 19.3 0.0 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain NOB1_Zn_bind PF08772.6 EFE44859.1 - 1.8e-32 110.9 2.9 3.7e-32 109.9 2.0 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.6 EFE44859.1 - 0.026 14.0 0.3 0.026 14.0 0.2 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain HypA PF01155.14 EFE44859.1 - 0.051 13.2 0.3 1.8 8.2 0.2 2.4 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 EFE44859.1 - 0.96 9.4 5.5 0.25 11.3 1.0 2.0 2 0 0 2 2 2 0 Zinc ribbon domain YqfQ PF14181.1 EFE44859.1 - 4.8 7.1 7.7 1.6 8.7 0.0 2.7 2 0 0 2 2 2 0 YqfQ-like protein AF1Q PF15017.1 EFE44859.1 - 8 6.4 19.8 9.3 6.2 11.2 3.0 2 1 0 2 2 2 0 Drug resistance and apoptosis regulator Peptidase_M18 PF02127.10 EFE44860.1 - 6.3e-131 436.8 0.0 7.2e-131 436.6 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) HTH_38 PF13936.1 EFE44860.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain ABC_tran PF00005.22 EFE44861.1 - 8.5e-51 171.8 0.0 1.1e-25 90.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 EFE44861.1 - 2.2e-24 86.1 47.1 2.7e-16 59.5 18.0 2.6 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.1 EFE44861.1 - 3e-22 79.9 0.0 0.00012 22.2 0.0 4.4 4 0 0 4 4 4 4 AAA domain AAA_29 PF13555.1 EFE44861.1 - 5.2e-10 38.6 7.8 1.6e-05 24.3 0.3 3.4 4 0 0 4 4 4 2 P-loop containing region of AAA domain SMC_N PF02463.14 EFE44861.1 - 7e-10 38.5 1.1 0.0002 20.6 0.1 3.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFE44861.1 - 7.1e-10 39.5 1.6 0.001 19.4 0.1 2.5 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFE44861.1 - 7.8e-06 25.1 0.2 0.028 13.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 EFE44861.1 - 0.00019 21.4 0.1 0.73 9.7 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.1 EFE44861.1 - 0.00027 20.1 0.0 0.18 10.8 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.1 EFE44861.1 - 0.0018 18.1 0.3 8.7 6.3 0.1 4.2 3 2 0 3 3 3 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 EFE44861.1 - 0.0025 17.2 0.0 2.9 7.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.1 EFE44861.1 - 0.0031 17.1 0.7 0.65 9.5 0.1 3.0 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.1 EFE44861.1 - 0.008 16.1 0.1 0.82 9.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EFE44861.1 - 0.017 14.2 0.5 2.9 6.9 0.0 3.0 3 0 0 3 3 3 0 Zeta toxin DUF4162 PF13732.1 EFE44861.1 - 0.017 15.6 0.0 0.074 13.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) MMR_HSR1 PF01926.18 EFE44861.1 - 0.026 14.4 0.1 11 6.0 0.0 2.9 3 0 0 3 3 3 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 EFE44861.1 - 0.035 13.5 0.1 0.19 11.1 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_13 PF13166.1 EFE44861.1 - 0.036 12.5 0.0 0.86 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 EFE44861.1 - 0.04 13.3 0.4 7.3 5.9 0.1 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_19 PF13245.1 EFE44861.1 - 0.051 13.3 1.1 12 5.7 0.1 3.1 2 0 0 2 2 2 0 Part of AAA domain AAA_22 PF13401.1 EFE44861.1 - 0.058 13.5 0.3 11 6.1 0.1 2.8 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EFE44861.1 - 0.068 12.6 0.1 9.3 5.5 0.2 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_33 PF13671.1 EFE44861.1 - 0.45 10.3 1.2 29 4.5 0.2 2.6 2 0 0 2 2 2 0 AAA domain MFS_1 PF07690.11 EFE44862.1 - 1.8e-19 69.6 3.6 3.2e-19 68.8 2.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily NdhL PF10716.4 EFE44862.1 - 0.089 12.5 0.5 0.24 11.2 0.0 1.9 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit ABC2_membrane PF01061.19 EFE44863.1 - 2e-83 278.7 50.4 3.3e-44 150.5 9.8 3.4 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.22 EFE44863.1 - 2.2e-34 118.6 0.0 8.6e-17 61.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 EFE44863.1 - 2e-25 88.3 0.1 5.2e-21 74.2 0.0 2.9 2 0 0 2 2 2 2 CDR ABC transporter AAA_21 PF13304.1 EFE44863.1 - 4.8e-06 26.7 0.6 0.091 12.7 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA_33 PF13671.1 EFE44863.1 - 8.7e-06 25.6 0.1 0.00051 19.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFE44863.1 - 0.00031 20.1 0.1 0.011 15.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain ABC2_membrane_3 PF12698.2 EFE44863.1 - 0.00075 18.6 8.3 0.00075 18.6 5.7 4.6 3 1 1 4 4 4 2 ABC-2 family transporter protein AAA_29 PF13555.1 EFE44863.1 - 0.00076 18.9 0.6 0.0046 16.4 0.1 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.11 EFE44863.1 - 0.00089 18.4 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 cobW PF02492.14 EFE44863.1 - 0.0019 17.7 0.5 0.0044 16.4 0.3 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 EFE44863.1 - 0.0023 17.8 0.1 0.04 13.8 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFE44863.1 - 0.0026 18.5 0.0 0.044 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFE44863.1 - 0.0041 17.1 0.2 0.068 13.1 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain UPF0079 PF02367.12 EFE44863.1 - 0.0077 15.8 0.8 0.91 9.1 0.1 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 EFE44863.1 - 0.011 15.8 0.4 0.085 12.9 0.0 2.6 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.14 EFE44863.1 - 0.015 14.5 0.1 0.75 8.9 0.0 2.6 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 EFE44863.1 - 0.02 15.2 0.1 0.23 11.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 EFE44863.1 - 0.027 14.1 0.1 4.4 7.1 0.1 2.6 2 0 0 2 2 2 0 Part of AAA domain Arch_ATPase PF01637.13 EFE44863.1 - 0.067 12.8 0.5 16 5.1 0.0 2.8 3 0 0 3 3 3 0 Archaeal ATPase PduV-EutP PF10662.4 EFE44863.1 - 0.098 12.1 0.4 1.9 7.9 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Adap_comp_sub PF00928.16 EFE44864.1 - 9.2e-82 274.0 0.0 1.4e-81 273.4 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EFE44864.1 - 8.5e-08 32.0 0.3 1.4e-07 31.3 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribonucleas_3_3 PF14622.1 EFE44865.1 - 1.8e-15 57.0 0.0 2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 EFE44865.1 - 0.019 15.3 0.0 0.025 15.0 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease III domain Sdh_cyt PF01127.17 EFE44867.1 - 3.2e-24 85.0 4.1 4.2e-24 84.6 2.8 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit CybS PF05328.7 EFE44867.1 - 0.12 12.0 0.3 0.21 11.2 0.2 1.4 1 0 0 1 1 1 0 CybS NMO PF03060.10 EFE44868.1 - 7.4e-43 146.9 0.0 9.3e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFE44868.1 - 0.00037 19.5 1.9 0.00043 19.2 0.5 1.6 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EFE44868.1 - 0.0044 15.9 0.2 0.0067 15.3 0.2 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.9 EFE44868.1 - 0.0087 15.0 0.1 0.027 13.4 0.0 1.8 1 1 1 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase Hydrophobin PF01185.13 EFE44870.1 - 6.5e-09 36.1 11.6 8.7e-09 35.7 8.0 1.2 1 0 0 1 1 1 1 Fungal hydrophobin WW PF00397.21 EFE44871.1 - 1.6e-08 34.2 1.9 3.9e-08 33.0 1.3 1.6 1 0 0 1 1 1 1 WW domain Ank_2 PF12796.2 EFE44872.1 - 4.2e-15 55.8 1.0 1.6e-14 53.9 0.5 2.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFE44872.1 - 8.6e-14 50.5 0.5 1.5e-10 40.3 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 EFE44872.1 - 5.2e-13 48.7 1.6 4e-08 33.2 0.5 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFE44872.1 - 7.8e-13 48.5 1.0 5.3e-08 33.1 0.2 2.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFE44872.1 - 6e-12 44.5 0.8 1.5e-07 30.9 0.1 3.3 4 0 0 4 4 4 2 Ankyrin repeat UPF0128 PF03673.8 EFE44872.1 - 0.055 12.7 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Glyco_transf_21 PF13506.1 EFE44873.1 - 3.4e-12 46.0 0.0 3.8e-06 26.2 0.0 3.3 1 1 1 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.1 EFE44873.1 - 2e-11 44.1 0.0 4.1e-11 43.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 AbfB PF05270.8 EFE44873.1 - 0.093 12.4 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase B (ABFB) E1-E2_ATPase PF00122.15 EFE44874.1 - 4.1e-50 169.9 1.0 8e-50 169.0 0.7 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFE44874.1 - 5.3e-30 104.3 4.6 5.3e-30 104.3 3.2 3.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFE44874.1 - 9.2e-22 78.5 0.0 5.6e-21 75.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFE44874.1 - 1.4e-12 46.9 0.0 4.2e-12 45.3 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 EFE44874.1 - 4.9e-12 45.6 0.0 1.2e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFE44874.1 - 4.5e-11 43.2 0.0 2e-10 41.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE44874.1 - 1.4e-05 24.8 0.1 2.9e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1625 PF07787.7 EFE44874.1 - 0.0055 15.9 2.3 1.1 8.4 0.5 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1625) DUF2207 PF09972.4 EFE44874.1 - 1.1 7.7 6.4 2 6.9 0.1 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) PGG PF13962.1 EFE44874.1 - 3.1 7.4 8.4 1.5 8.4 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function KAT11 PF08214.6 EFE44875.1 - 1.7e-90 303.6 0.0 2.1e-90 303.3 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein Cupin_2 PF07883.6 EFE44876.1 - 3.6e-07 29.5 0.1 5.8e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cathelicidins PF00666.12 EFE44876.1 - 0.083 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Cathelicidin Hid1 PF12722.2 EFE44878.1 - 1.7e-273 909.5 0.0 3e-273 908.7 0.0 1.4 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 EFE44878.1 - 1.2e-69 235.2 0.0 5e-69 233.1 0.0 1.8 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Vps54 PF07928.7 EFE44882.1 - 8.6e-46 155.4 0.0 2.5e-45 153.8 0.0 1.9 1 0 0 1 1 1 1 Vps54-like protein DUF2450 PF10475.4 EFE44882.1 - 1.5e-05 24.0 0.3 4.9e-05 22.3 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 EFE44882.1 - 0.0015 18.3 0.5 0.0034 17.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Cytochrom_B562 PF07361.6 EFE44882.1 - 0.087 13.2 0.2 0.5 10.7 0.2 2.3 2 0 0 2 2 2 0 Cytochrome b562 Pkinase PF00069.20 EFE44883.1 - 1.2e-23 83.6 0.0 1.6e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE44883.1 - 1.3e-08 34.2 0.0 0.0022 17.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 EFE44883.1 - 0.068 12.8 0.1 0.15 11.7 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family rve PF00665.21 EFE44884.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain U3_snoRNA_assoc PF08297.6 EFE44885.1 - 1.4e-07 31.5 0.0 1.4e-07 31.5 0.0 4.2 3 2 0 3 3 3 1 U3 snoRNA associated DUF4604 PF15377.1 EFE44885.1 - 3.4 7.8 34.1 0.24 11.6 14.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) LMBR1 PF04791.11 EFE44885.1 - 8 4.9 5.9 12 4.3 4.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CTK3 PF12243.3 EFE44886.1 - 8.7e-57 190.6 0.2 1.3e-56 190.1 0.2 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.3 EFE44886.1 - 8.6e-21 73.7 9.9 2.5e-20 72.2 6.9 1.8 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus P5CR_dimer PF14748.1 EFE44887.1 - 3.1e-30 104.3 2.4 5.4e-30 103.5 1.7 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 EFE44887.1 - 3e-08 33.9 0.0 1.7e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Voltage_CLC PF00654.15 EFE44888.1 - 1.4e-74 251.2 28.4 2.4e-68 230.7 13.2 2.5 2 1 1 3 3 3 2 Voltage gated chloride channel CBS PF00571.23 EFE44888.1 - 0.00046 19.9 0.1 0.0089 15.7 0.0 2.7 2 1 0 2 2 2 1 CBS domain SSDP PF04503.8 EFE44888.1 - 0.041 13.6 4.2 0.065 12.9 2.9 1.2 1 0 0 1 1 1 0 Single-stranded DNA binding protein, SSDP AAA_5 PF07728.9 EFE44889.1 - 4.2e-138 454.2 0.0 2.1e-24 85.8 0.0 10.1 10 1 0 10 10 9 9 AAA domain (dynein-related subfamily) AAA PF00004.24 EFE44889.1 - 5.1e-33 114.0 0.0 4e-05 23.8 0.0 6.7 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.6 EFE44889.1 - 1.8e-31 108.4 0.0 1.1e-10 41.1 0.0 7.4 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFE44889.1 - 2e-25 89.8 13.8 4.2e-05 23.6 0.1 7.4 7 1 0 7 7 6 6 AAA ATPase domain AAA_22 PF13401.1 EFE44889.1 - 8.3e-23 80.9 2.1 0.026 14.6 0.0 8.6 7 2 0 7 7 6 6 AAA domain AAA_17 PF13207.1 EFE44889.1 - 9.7e-22 78.0 0.0 0.0016 19.2 0.0 6.8 6 0 0 6 6 6 4 AAA domain AAA_33 PF13671.1 EFE44889.1 - 8.1e-21 74.4 0.0 0.014 15.3 0.0 7.7 6 2 0 6 6 6 4 AAA domain Sigma54_activat PF00158.21 EFE44889.1 - 1.1e-20 73.7 0.0 0.0078 15.6 0.0 6.6 6 0 0 6 6 6 5 Sigma-54 interaction domain AAA_14 PF13173.1 EFE44889.1 - 2.7e-19 69.3 0.0 2.8e-05 24.0 0.0 7.9 7 0 0 7 7 7 2 AAA domain AAA_18 PF13238.1 EFE44889.1 - 1.4e-18 67.3 0.4 0.037 14.3 0.0 6.9 7 0 0 7 7 6 3 AAA domain Sigma54_activ_2 PF14532.1 EFE44889.1 - 4.3e-18 65.6 0.6 0.0019 18.2 0.0 7.5 7 0 0 7 7 6 2 Sigma-54 interaction domain Mg_chelatase PF01078.16 EFE44889.1 - 1e-16 60.7 7.3 0.26 10.4 0.0 9.4 8 2 1 9 9 9 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EFE44889.1 - 1.7e-16 59.7 2.3 0.053 13.2 0.1 6.7 6 0 0 6 6 6 3 Part of AAA domain ABC_tran PF00005.22 EFE44889.1 - 8.5e-16 58.4 1.9 0.011 16.0 0.0 6.5 6 0 0 6 6 6 3 ABC transporter UPF0079 PF02367.12 EFE44889.1 - 1.5e-15 56.9 3.1 0.078 12.6 0.0 6.2 6 0 0 6 6 6 4 Uncharacterised P-loop hydrolase UPF0079 Zeta_toxin PF06414.7 EFE44889.1 - 6.1e-15 54.8 6.8 0.0026 16.8 0.0 7.9 8 0 0 8 8 8 3 Zeta toxin NACHT PF05729.7 EFE44889.1 - 3.8e-13 49.4 8.0 0.069 12.8 0.1 7.4 7 0 0 7 7 7 2 NACHT domain AAA_30 PF13604.1 EFE44889.1 - 4.6e-13 49.1 0.4 1.2 8.6 0.0 7.5 7 1 0 7 7 6 2 AAA domain RNA_helicase PF00910.17 EFE44889.1 - 7.9e-13 48.5 0.5 0.63 10.2 0.0 6.5 6 0 0 6 6 6 1 RNA helicase RuvB_N PF05496.7 EFE44889.1 - 8.6e-13 47.8 2.2 0.14 11.1 0.0 6.3 7 0 0 7 7 6 4 Holliday junction DNA helicase ruvB N-terminus Miro PF08477.8 EFE44889.1 - 1.7e-12 47.8 1.4 0.59 10.6 0.0 6.5 6 0 0 6 6 6 1 Miro-like protein DUF815 PF05673.8 EFE44889.1 - 3.9e-12 45.6 1.7 0.32 9.9 0.1 6.2 6 0 0 6 6 6 2 Protein of unknown function (DUF815) T2SE PF00437.15 EFE44889.1 - 4.2e-12 45.5 0.4 0.04 12.8 0.0 5.6 6 0 0 6 6 5 2 Type II/IV secretion system protein AAA_29 PF13555.1 EFE44889.1 - 5.4e-12 45.0 0.4 0.17 11.4 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EFE44889.1 - 2.7e-11 43.2 0.5 0.32 10.3 0.0 6.1 6 0 0 6 6 5 2 AAA domain AAA_2 PF07724.9 EFE44889.1 - 4.6e-11 42.9 0.0 0.25 11.2 0.0 6.3 6 0 0 6 6 6 2 AAA domain (Cdc48 subfamily) Arch_ATPase PF01637.13 EFE44889.1 - 6.9e-11 42.2 0.0 3.4 7.2 0.0 6.2 6 0 0 6 6 6 0 Archaeal ATPase SRP54 PF00448.17 EFE44889.1 - 8.5e-11 41.6 2.2 0.46 9.8 0.0 6.0 6 0 0 6 6 6 2 SRP54-type protein, GTPase domain PduV-EutP PF10662.4 EFE44889.1 - 1e-10 41.2 1.3 0.13 11.7 0.0 6.3 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.12 EFE44889.1 - 2.3e-10 40.1 0.1 1.2 8.4 0.0 6.3 6 0 0 6 6 6 2 IstB-like ATP binding protein AAA_28 PF13521.1 EFE44889.1 - 4.6e-10 39.6 7.1 0.1 12.5 0.0 6.2 6 0 0 6 6 6 3 AAA domain DUF258 PF03193.11 EFE44889.1 - 2.9e-09 36.2 5.6 0.23 10.6 0.2 6.1 6 0 0 6 6 6 1 Protein of unknown function, DUF258 MobB PF03205.9 EFE44889.1 - 1.3e-08 34.6 0.7 5 6.8 0.0 6.3 6 0 0 6 6 6 0 Molybdopterin guanine dinucleotide synthesis protein B ResIII PF04851.10 EFE44889.1 - 8.1e-08 32.3 0.1 0.12 12.2 0.0 5.2 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit TIP49 PF06068.8 EFE44889.1 - 9.7e-08 31.1 2.3 0.48 9.0 0.0 5.2 5 0 0 5 5 5 1 TIP49 C-terminus AAA_23 PF13476.1 EFE44889.1 - 2.6e-07 31.1 0.0 1.6 8.9 0.0 6.4 6 0 0 6 6 6 1 AAA domain AAA_7 PF12775.2 EFE44889.1 - 8.3e-07 28.3 0.7 1.3 8.0 0.0 5.3 5 0 0 5 5 5 1 P-loop containing dynein motor region D3 Rad17 PF03215.10 EFE44889.1 - 8.9e-07 27.9 1.5 0.082 11.5 0.0 5.2 6 0 0 6 6 5 1 Rad17 cell cycle checkpoint protein Bac_DnaA PF00308.13 EFE44889.1 - 3.8e-06 26.7 0.0 1.4 8.4 0.0 4.8 5 0 0 5 5 4 1 Bacterial dnaA protein NTPase_1 PF03266.10 EFE44889.1 - 4e-06 26.6 5.3 0.99 9.0 0.0 6.3 7 0 0 7 7 5 1 NTPase AAA_11 PF13086.1 EFE44889.1 - 6.3e-06 25.9 0.0 0.65 9.5 0.0 5.1 6 0 0 6 6 5 1 AAA domain AAA_24 PF13479.1 EFE44889.1 - 7.1e-06 25.7 0.1 5.9 6.4 0.0 5.4 6 0 0 6 6 5 0 AAA domain SRPRB PF09439.5 EFE44889.1 - 5.5e-05 22.4 1.3 8.1 5.6 0.1 5.7 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit MCM PF00493.18 EFE44889.1 - 8.2e-05 21.5 0.0 13 4.4 0.0 4.6 4 0 0 4 4 4 0 MCM2/3/5 family KaiC PF06745.8 EFE44889.1 - 0.00011 21.4 0.7 5.6 6.0 0.0 4.8 6 0 0 6 6 4 0 KaiC AAA_6 PF12774.2 EFE44889.1 - 0.00011 21.8 0.0 19 4.6 0.0 6.9 7 2 0 7 7 6 0 Hydrolytic ATP binding site of dynein motor region D1 Dynein_heavy PF03028.10 EFE44889.1 - 0.00011 20.3 0.1 0.47 8.4 0.0 5.1 6 0 0 6 6 6 1 Dynein heavy chain and region D6 of dynein motor CPT PF07931.7 EFE44889.1 - 0.00017 21.2 4.5 0.57 9.7 0.0 6.1 7 1 0 7 7 4 1 Chloramphenicol phosphotransferase-like protein Viral_helicase1 PF01443.13 EFE44889.1 - 0.00017 21.1 0.5 5.1 6.5 0.0 5.4 6 0 0 6 6 5 0 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.18 EFE44889.1 - 0.00029 20.7 2.1 25 4.8 0.0 6.0 6 0 0 6 6 6 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 EFE44889.1 - 0.00033 20.2 5.9 7.7 5.9 0.0 5.7 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein PhoH PF02562.11 EFE44889.1 - 0.00033 19.9 0.3 5.9 6.0 0.0 4.9 5 0 0 5 5 5 0 PhoH-like protein cobW PF02492.14 EFE44889.1 - 0.00034 20.1 7.2 3.7 6.9 0.1 5.6 6 0 0 6 6 6 0 CobW/HypB/UreG, nucleotide-binding domain DEAD PF00270.24 EFE44889.1 - 0.00047 19.7 0.2 12 5.3 0.0 5.0 6 0 0 6 6 4 0 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.13 EFE44889.1 - 0.0012 18.3 0.3 24 4.2 0.0 4.9 5 0 0 5 5 4 0 FtsK/SpoIIIE family ATP-synt_ab PF00006.20 EFE44889.1 - 0.0014 18.1 0.0 7.8 5.9 0.0 4.5 5 0 0 5 5 5 0 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.17 EFE44889.1 - 0.0037 16.1 0.3 30 3.3 0.0 4.5 5 0 0 5 5 5 0 NB-ARC domain PRK PF00485.13 EFE44889.1 - 0.0062 16.1 0.0 16 4.9 0.0 4.6 5 0 0 5 5 4 0 Phosphoribulokinase / Uridine kinase family KTI12 PF08433.5 EFE44889.1 - 0.0096 15.1 0.9 13 4.8 0.0 4.3 4 0 0 4 4 4 0 Chromatin associated protein KTI12 DnaB_C PF03796.10 EFE44889.1 - 0.014 14.3 1.1 3.1 6.6 0.0 3.2 3 0 0 3 3 3 0 DnaB-like helicase C terminal domain G-alpha PF00503.15 EFE44889.1 - 0.024 13.3 1.5 8.9 4.8 0.0 3.8 5 0 0 5 5 3 0 G-protein alpha subunit Ras PF00071.17 EFE44889.1 - 0.043 13.2 3.0 27 4.1 0.0 4.8 5 0 0 5 5 5 0 Ras family AAA_15 PF13175.1 EFE44889.1 - 0.064 12.2 0.0 11 4.9 0.0 3.3 4 0 0 4 4 3 0 AAA ATPase domain Gtr1_RagA PF04670.7 EFE44889.1 - 0.071 12.2 3.2 34 3.4 0.0 4.7 5 0 0 5 5 4 0 Gtr1/RagA G protein conserved region IPT PF01745.11 EFE44889.1 - 0.082 12.0 1.4 38 3.3 0.0 4.4 5 0 0 5 5 4 0 Isopentenyl transferase CbiA PF01656.18 EFE44889.1 - 0.086 12.2 3.1 3.8 6.8 0.0 3.9 5 0 0 5 5 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Thymidylate_kin PF02223.12 EFE44889.1 - 0.096 12.0 0.5 1e+02 2.1 0.0 4.9 4 0 0 4 4 4 0 Thymidylate kinase AAA_10 PF12846.2 EFE44889.1 - 0.12 11.8 1.8 44 3.3 0.0 4.9 5 0 0 5 5 4 0 AAA-like domain Parvo_NS1 PF01057.12 EFE44889.1 - 0.13 11.0 0.0 15 4.3 0.0 3.4 4 0 0 4 4 4 0 Parvovirus non-structural protein NS1 PIF1 PF05970.9 EFE44889.1 - 0.19 10.6 1.0 58 2.4 0.0 4.7 7 0 0 7 7 5 0 PIF1-like helicase SMC_N PF02463.14 EFE44889.1 - 0.28 10.3 0.0 11 5.2 0.0 3.5 6 0 0 6 6 2 0 RecF/RecN/SMC N terminal domain Y_phosphatase PF00102.22 EFE44889.1 - 0.42 9.9 0.1 43 3.3 0.0 3.0 3 0 0 3 3 3 0 Protein-tyrosine phosphatase tRNA_lig_kinase PF08303.6 EFE44889.1 - 0.42 10.4 0.8 4.1 7.2 0.0 2.9 4 0 0 4 4 2 0 tRNA ligase kinase domain FeoB_N PF02421.13 EFE44889.1 - 0.5 9.6 4.3 67 2.7 0.0 4.7 6 0 0 6 6 4 0 Ferrous iron transport protein B DUF2075 PF09848.4 EFE44889.1 - 0.54 9.1 0.4 23 3.8 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Septin PF00735.13 EFE44889.1 - 2.4 7.0 3.7 17 4.3 0.0 3.8 6 0 0 6 6 5 0 Septin AAA_PrkA PF08298.6 EFE44889.1 - 3.7 6.1 5.1 29 3.2 0.0 3.5 5 0 0 5 5 3 0 PrkA AAA domain Ala_racemase_N PF01168.15 EFE44891.1 - 8.9e-41 139.8 0.0 1.3e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Adaptin_N PF01602.15 EFE44892.1 - 6.8e-124 414.0 4.8 8.9e-124 413.6 3.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.11 EFE44892.1 - 4.7e-40 136.0 0.0 1.2e-39 134.7 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.15 EFE44892.1 - 7.6e-18 64.9 0.1 3e-17 62.9 0.0 2.1 3 0 0 3 3 3 1 Adaptin C-terminal domain efThoc1 PF11957.3 EFE44896.1 - 4.9e-157 523.3 3.5 6.4e-157 522.9 2.4 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor AAA_12 PF13087.1 EFE44897.1 - 2.5e-25 89.0 0.0 4.4e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EFE44897.1 - 1.1e-24 87.2 0.0 1.9e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE44897.1 - 1.3e-09 37.6 0.0 6.9e-09 35.3 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 EFE44897.1 - 2.7e-06 27.1 0.0 0.00047 19.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 EFE44897.1 - 0.0002 21.2 0.0 0.00044 20.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.13 EFE44897.1 - 0.00023 20.7 0.1 0.26 10.7 0.0 3.0 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 EFE44897.1 - 0.0013 18.1 0.5 0.0045 16.3 0.0 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DEAD PF00270.24 EFE44897.1 - 0.0017 17.8 0.1 0.027 13.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA PF00004.24 EFE44897.1 - 0.0026 17.9 0.0 0.01 16.0 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFE44897.1 - 0.0027 17.8 0.0 0.019 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFE44897.1 - 0.0045 16.4 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.9 EFE44897.1 - 0.0057 15.6 0.0 0.61 8.9 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase AAA_16 PF13191.1 EFE44897.1 - 0.0074 16.2 0.0 0.029 14.3 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 EFE44897.1 - 0.018 14.7 0.0 0.039 13.6 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase Zeta_toxin PF06414.7 EFE44897.1 - 0.023 13.7 0.0 0.048 12.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin DnaB_C PF03796.10 EFE44897.1 - 0.035 12.9 0.0 0.071 11.9 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_5 PF07728.9 EFE44897.1 - 0.035 13.8 0.0 0.16 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 EFE44897.1 - 0.046 12.6 0.7 0.085 11.8 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 EFE44897.1 - 0.06 13.2 0.0 0.41 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EFE44897.1 - 0.083 11.7 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_17 PF13207.1 EFE44897.1 - 0.088 13.6 0.4 4.8 8.0 0.1 3.6 3 1 0 3 3 2 0 AAA domain cobW PF02492.14 EFE44897.1 - 0.14 11.5 0.1 0.48 9.8 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Transp_cyt_pur PF02133.10 EFE44898.1 - 2.6e-87 293.1 35.3 3.8e-87 292.6 24.5 1.2 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Tfb2 PF03849.9 EFE44899.1 - 4.7e-108 361.1 0.0 8.6e-108 360.2 0.0 1.4 2 0 0 2 2 2 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 EFE44899.1 - 4e-06 26.5 0.0 4.2e-05 23.3 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SinI PF08671.5 EFE44899.1 - 0.013 14.8 0.0 0.035 13.5 0.0 1.7 1 0 0 1 1 1 0 Anti-repressor SinI PhzC-PhzF PF02567.11 EFE44901.1 - 1.2e-42 146.1 0.3 3e-42 144.7 0.2 1.6 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein TIMELESS PF04821.9 EFE44902.1 - 4.7e-54 183.4 0.0 4.7e-54 183.4 0.0 2.3 3 0 0 3 3 3 1 Timeless protein TIMELESS_C PF05029.8 EFE44902.1 - 1.3e-40 139.9 23.9 8.6e-38 130.6 11.0 4.1 2 1 0 2 2 2 2 Timeless protein C terminal region 3HCDH_N PF02737.13 EFE44903.1 - 2e-52 177.4 1.0 2.6e-52 177.0 0.7 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 EFE44903.1 - 1.9e-34 117.9 0.0 4.4e-34 116.7 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 EFE44903.1 - 3.9e-05 23.5 0.5 0.0001 22.1 0.3 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 EFE44903.1 - 0.00027 20.6 0.1 0.00042 20.0 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 EFE44903.1 - 0.0003 20.2 0.1 0.014 14.8 0.0 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Saccharop_dh PF03435.13 EFE44903.1 - 0.0055 15.7 0.1 0.0068 15.4 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase DAO PF01266.19 EFE44903.1 - 0.0071 15.2 0.0 0.011 14.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFE44903.1 - 0.017 15.4 0.2 0.04 14.3 0.0 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EFE44903.1 - 0.02 14.2 0.0 0.039 13.3 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.14 EFE44903.1 - 0.05 12.7 1.0 0.51 9.4 0.7 2.1 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EFE44903.1 - 0.056 13.8 1.9 0.24 11.8 1.3 2.2 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.9 EFE44903.1 - 0.082 12.7 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 EFE44903.1 - 0.087 12.8 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain IBR PF01485.16 EFE44904.1 - 2.8e-07 30.3 13.4 8.3e-06 25.5 5.6 2.5 2 0 0 2 2 2 2 IBR domain Actin PF00022.14 EFE44905.1 - 1.5e-83 280.3 0.0 1.8e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 Actin GCIP PF13324.1 EFE44906.1 - 3.5e-09 36.2 1.9 5.5e-09 35.6 1.3 1.4 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Sigma70_ner PF04546.8 EFE44906.1 - 0.0025 17.4 1.4 0.0042 16.7 1.0 1.3 1 0 0 1 1 1 1 Sigma-70, non-essential region Nucleopor_Nup85 PF07575.8 EFE44906.1 - 0.079 11.1 0.0 0.14 10.3 0.0 1.4 1 0 0 1 1 1 0 Nup85 Nucleoporin LRR_4 PF12799.2 EFE44907.1 - 3.8e-35 118.9 49.0 4.3e-09 35.7 0.6 11.3 8 2 5 13 13 13 11 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFE44907.1 - 1.5e-31 107.8 41.6 5.9e-08 32.3 1.4 8.4 7 1 1 8 8 8 7 Leucine rich repeat LRR_1 PF00560.28 EFE44907.1 - 5.6e-17 59.1 38.4 0.1 12.6 0.0 16.5 15 2 1 16 16 16 5 Leucine Rich Repeat LRR_7 PF13504.1 EFE44907.1 - 2.6e-14 50.8 38.4 0.27 11.5 0.1 15.6 16 0 0 16 16 16 5 Leucine rich repeat LRR_6 PF13516.1 EFE44907.1 - 1.5e-06 27.6 36.1 0.84 9.9 0.1 12.8 15 0 0 15 15 15 2 Leucine Rich repeat LRR_9 PF14580.1 EFE44907.1 - 0.00012 21.7 11.9 0.069 12.6 0.4 3.7 2 1 0 3 3 3 3 Leucine-rich repeat TMF_TATA_bd PF12325.3 EFE44909.1 - 0.011 15.4 8.6 0.021 14.5 6.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Mto2_bdg PF12808.2 EFE44909.1 - 0.14 12.2 5.2 0.16 12.0 0.8 2.6 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region GrpE PF01025.14 EFE44909.1 - 0.54 9.7 7.5 5.5 6.4 0.3 2.3 2 0 0 2 2 2 0 GrpE Atg14 PF10186.4 EFE44909.1 - 1.4 7.7 11.2 2.6 6.9 7.8 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 EFE44909.1 - 3.4 7.2 11.1 9.7 5.7 7.7 1.6 1 1 0 1 1 1 0 IncA protein Ribosomal_L13e PF01294.13 EFE44910.1 - 1e-64 217.3 4.5 1.4e-64 216.8 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e DUF4404 PF14357.1 EFE44911.1 - 0.2 12.0 4.0 5.8 7.4 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Asp-B-Hydro_N PF05279.6 EFE44911.1 - 0.43 10.3 3.8 0.95 9.2 2.6 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Siah-Interact_N PF09032.6 EFE44911.1 - 1.9 8.6 9.3 8.7 6.4 2.6 2.7 2 0 0 2 2 2 0 Siah interacting protein, N terminal Oxidored-like PF09791.4 EFE44912.1 - 5.8e-26 89.6 4.5 5.8e-26 89.6 3.1 2.3 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal KAP PF05804.7 EFE44913.1 - 0.0024 15.8 0.1 0.0053 14.7 0.0 1.5 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) Pribosyltran PF00156.22 EFE44915.1 - 4.6e-08 32.8 0.3 9e-07 28.6 0.2 2.1 1 1 0 1 1 1 1 Phosphoribosyl transferase domain RNase_H2-Ydr279 PF09468.5 EFE44916.1 - 0.0087 15.2 8.7 0.0085 15.3 6.0 1.1 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) GAPT PF11770.3 EFE44916.1 - 0.034 13.8 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) DUF3767 PF12597.3 EFE44916.1 - 0.037 13.6 3.2 0.057 13.0 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) FLO_LFY PF01698.11 EFE44916.1 - 0.29 9.9 11.0 0.34 9.6 7.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DDHD PF02862.12 EFE44916.1 - 0.32 10.7 6.7 0.38 10.4 4.6 1.0 1 0 0 1 1 1 0 DDHD domain SHR3_chaperone PF08229.6 EFE44916.1 - 2.4 7.0 7.9 0.6 9.0 3.6 1.4 1 1 1 2 2 2 0 ER membrane protein SH3 Pup PF05639.6 EFE44916.1 - 3.5 8.1 11.9 5 7.6 1.3 2.3 2 1 0 2 2 2 0 Pup-like protein Conotoxin PF02950.12 EFE44916.1 - 8.1 7.3 6.7 2.7 8.8 0.7 2.2 2 0 0 2 2 2 0 Conotoxin HSF_DNA-bind PF00447.12 EFE44917.1 - 4e-36 123.3 0.7 9.1e-36 122.1 0.2 1.8 2 0 0 2 2 2 1 HSF-type DNA-binding Gti1_Pac2 PF09729.4 EFE44917.1 - 0.057 13.2 0.1 0.58 10.0 0.6 2.0 2 0 0 2 2 2 0 Gti1/Pac2 family Menin PF05053.8 EFE44917.1 - 1.7 6.7 7.9 2.4 6.1 5.5 1.1 1 0 0 1 1 1 0 Menin Plasmodium_Vir PF05795.6 EFE44918.1 - 3.5 6.7 7.0 2.6 7.1 1.0 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF3245 PF11595.3 EFE44919.1 - 2e-40 138.5 4.7 2.6e-40 138.1 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3245) PTRF_SDPR PF15237.1 EFE44919.1 - 0.02 14.2 0.6 0.025 13.9 0.4 1.2 1 0 0 1 1 1 0 PTRF/SDPR family Ribosomal_60s PF00428.14 EFE44919.1 - 0.13 12.6 2.5 8.3 6.8 0.2 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein ATP-grasp_2 PF08442.5 EFE44920.1 - 3.9e-79 264.7 0.2 6.3e-79 264.0 0.2 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 EFE44920.1 - 5.1e-25 87.8 0.8 1.6e-24 86.2 0.2 2.0 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.1 EFE44920.1 - 3.9e-09 36.0 0.3 8.7e-09 34.9 0.1 1.7 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.14 EFE44920.1 - 8.1e-05 22.2 0.8 0.022 14.3 0.0 2.6 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Succ_CoA_lig PF13607.1 EFE44920.1 - 0.0041 16.7 0.3 1.3 8.6 0.0 2.7 1 1 1 2 2 2 2 Succinyl-CoA ligase like flavodoxin domain ATP-grasp_4 PF13535.1 EFE44920.1 - 0.017 14.8 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain Spore-coat_CotZ PF10612.4 EFE44920.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Spore coat protein Z adh_short PF00106.20 EFE44921.1 - 0.00063 19.6 0.0 0.00074 19.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EFE44921.1 - 0.0029 17.6 0.0 0.0032 17.5 0.0 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFE44921.1 - 0.017 14.3 0.0 0.02 14.1 0.0 1.0 1 0 0 1 1 1 0 NmrA-like family adh_short_C2 PF13561.1 EFE44921.1 - 0.056 13.1 0.0 0.061 13.0 0.0 1.0 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase PAE PF03283.8 EFE44921.1 - 0.082 11.5 0.0 0.082 11.5 0.0 1.2 1 0 0 1 1 1 0 Pectinacetylesterase Beta-lactamase PF00144.19 EFE44922.1 - 5e-33 114.5 0.0 1e-31 110.2 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.15 EFE44922.1 - 0.17 11.1 0.0 0.35 10.0 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Peptidase_S8 PF00082.17 EFE44923.1 - 6.6e-42 143.6 13.1 8.9e-42 143.1 9.1 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE44923.1 - 2.8e-18 66.2 0.0 4.6e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 SLAC1 PF03595.12 EFE44924.1 - 2.6e-77 259.7 51.8 3e-77 259.4 35.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel TraP PF07296.6 EFE44924.1 - 0.28 10.1 1.7 0.4 9.6 0.2 1.8 2 0 0 2 2 2 0 TraP protein ABC1 PF03109.11 EFE44925.1 - 1.1e-22 80.1 0.0 3.1e-13 49.7 0.0 2.5 2 0 0 2 2 2 2 ABC1 family APH PF01636.18 EFE44925.1 - 0.052 13.2 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 EFE44925.1 - 0.074 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family DUF2238 PF09997.4 EFE44925.1 - 0.097 12.0 0.1 0.64 9.4 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2238) HA2 PF04408.18 EFE44926.1 - 4.2e-15 55.6 0.0 6.7e-14 51.7 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFE44926.1 - 3.1e-06 26.9 0.0 7.2e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 EFE44926.1 - 0.0057 16.4 0.0 0.037 13.8 0.0 2.5 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 EFE44926.1 - 0.0076 15.7 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFE44926.1 - 0.018 15.1 0.0 0.061 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 EFE44926.1 - 0.018 15.5 0.0 0.066 13.7 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein T2SE PF00437.15 EFE44926.1 - 0.049 12.5 0.0 0.09 11.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.1 EFE44926.1 - 0.087 12.5 0.1 0.51 10.1 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain DUF258 PF03193.11 EFE44926.1 - 0.14 11.3 0.1 0.27 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SSB PF00436.20 EFE44927.1 - 8.7e-14 51.2 0.0 1.3e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family STE3 PF02076.10 EFE44928.1 - 1.4e-83 280.2 10.6 1.7e-83 280.0 7.4 1.1 1 0 0 1 1 1 1 Pheromone A receptor Pex24p PF06398.6 EFE44928.1 - 0.013 14.2 2.5 0.021 13.6 1.7 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF4131 PF13567.1 EFE44928.1 - 1.6 8.1 7.3 0.19 11.1 1.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF3543 PF12063.3 EFE44929.1 - 0.011 15.0 0.5 0.025 13.8 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) IncA PF04156.9 EFE44929.1 - 0.033 13.7 3.9 0.075 12.6 2.5 1.8 1 1 0 1 1 1 0 IncA protein Imm10 PF15562.1 EFE44929.1 - 0.062 13.0 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 10 CCDC-167 PF15188.1 EFE44929.1 - 0.068 13.1 2.1 0.34 10.8 1.4 2.2 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Exo_endo_phos PF03372.18 EFE44930.1 - 1.2e-19 71.2 0.1 2e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DCP1 PF06058.8 EFE44931.1 - 1.1e-15 57.6 0.0 8.8e-15 54.8 0.0 2.0 2 0 0 2 2 2 1 Dcp1-like decapping family DUF1299 PF06975.6 EFE44931.1 - 0.0073 16.1 0.7 0.015 15.1 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1299) DUF2305 PF10230.4 EFE44932.1 - 1.2e-35 123.1 0.0 1.6e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_5 PF12695.2 EFE44932.1 - 5.1e-05 23.0 0.4 0.00025 20.8 0.3 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFE44932.1 - 0.0016 18.3 0.0 0.0019 18.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EFE44932.1 - 0.0065 16.7 0.1 0.015 15.5 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain Abhydrolase_3 PF07859.8 EFE44932.1 - 0.011 15.2 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3089 PF11288.3 EFE44932.1 - 0.021 13.9 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PGAP1 PF07819.8 EFE44932.1 - 0.023 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.20 EFE44932.1 - 0.025 14.1 0.0 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 3) SMK-1 PF04802.10 EFE44933.1 - 1.4e-73 246.5 0.4 2.6e-73 245.6 0.2 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Utp14 PF04615.8 EFE44933.1 - 0.58 8.2 17.6 0.84 7.7 12.2 1.1 1 0 0 1 1 1 0 Utp14 protein Daxx PF03344.10 EFE44933.1 - 4.7 5.5 21.5 7.3 4.9 14.9 1.2 1 0 0 1 1 1 0 Daxx Family Borrelia_lipo_1 PF05714.6 EFE44934.1 - 0.054 12.5 3.4 0.073 12.1 2.4 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Plasmodium_Vir PF05795.6 EFE44934.1 - 0.054 12.6 0.2 0.054 12.6 0.2 2.3 2 1 0 2 2 2 0 Plasmodium vivax Vir protein NPR3 PF03666.8 EFE44934.1 - 0.49 8.8 5.2 0.66 8.4 3.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spore_coat_CotO PF14153.1 EFE44934.1 - 2.7 7.3 15.9 59 3.0 13.3 1.3 1 1 0 1 1 1 0 Spore coat protein CotO CoA_binding_3 PF13727.1 EFE44934.1 - 2.8 7.7 12.1 28 4.4 0.0 2.2 2 0 0 2 2 2 0 CoA-binding domain DUF914 PF06027.7 EFE44935.1 - 7.1e-102 340.6 20.8 9.1e-102 340.3 14.4 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 EFE44935.1 - 3.8e-05 23.7 11.4 3.8e-05 23.7 7.9 2.5 2 1 1 3 3 3 2 EamA-like transporter family TPT PF03151.11 EFE44935.1 - 0.12 12.0 26.6 0.22 11.1 7.6 2.6 2 1 0 3 3 3 0 Triose-phosphate Transporter family BEX PF04538.7 EFE44936.1 - 0.087 13.0 1.2 0.13 12.4 0.8 1.3 1 0 0 1 1 1 0 Brain expressed X-linked like family UPF0561 PF10573.4 EFE44936.1 - 0.92 9.3 4.5 1.1 9.0 3.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 PAT1 PF09770.4 EFE44937.1 - 0.69 8.0 27.6 1 7.5 19.1 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cytochrom_C PF00034.16 EFE44937.1 - 3.2 8.6 11.2 5.2 7.9 0.2 3.2 3 0 0 3 3 3 0 Cytochrome c Rb_C PF08934.5 EFE44938.1 - 2.1 7.9 7.7 0.62 9.6 3.6 1.5 1 1 0 1 1 1 0 Rb C-terminal domain FLO_LFY PF01698.11 EFE44938.1 - 8.2 5.1 17.7 11 4.7 12.3 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein SprA-related PF12118.3 EFE44938.1 - 9.1 5.5 20.1 12 5.0 13.9 1.2 1 0 0 1 1 1 0 SprA-related family PAP_assoc PF03828.14 EFE44940.1 - 9.1e-18 63.9 0.1 2.1e-17 62.8 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 EFE44940.1 - 0.0064 16.8 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain SE PF08491.5 EFE44941.1 - 3.8e-73 245.7 0.0 4.8e-73 245.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 EFE44941.1 - 1.4e-10 40.7 0.3 2.7e-09 36.5 0.1 2.3 2 1 0 2 2 2 1 FAD binding domain DAO PF01266.19 EFE44941.1 - 1.6e-10 40.4 0.1 7.1e-07 28.4 0.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFE44941.1 - 1.2e-07 30.9 1.3 2.1e-05 23.5 1.1 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 EFE44941.1 - 2.6e-05 24.1 0.0 4.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFE44941.1 - 0.0002 20.5 0.0 0.00035 19.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.17 EFE44941.1 - 0.00029 19.8 0.2 0.0011 17.9 0.1 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 EFE44941.1 - 0.0003 20.7 0.5 0.0007 19.5 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFE44941.1 - 0.00084 17.9 0.8 0.002 16.7 0.1 1.9 3 0 0 3 3 3 1 HI0933-like protein Shikimate_DH PF01488.15 EFE44941.1 - 0.00091 19.3 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.22 EFE44941.1 - 0.00091 19.5 0.2 0.0044 17.3 0.1 2.1 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EFE44941.1 - 0.0012 18.0 1.8 0.0017 17.5 1.3 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase ApbA PF02558.11 EFE44941.1 - 0.0029 17.0 0.3 0.012 15.0 0.1 1.9 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.7 EFE44941.1 - 0.0031 16.5 0.4 0.006 15.5 0.3 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.9 EFE44941.1 - 0.0089 14.6 0.2 0.081 11.5 0.1 2.0 2 0 0 2 2 2 1 Tryptophan halogenase GMC_oxred_N PF00732.14 EFE44941.1 - 0.047 12.8 0.2 7.5 5.6 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase NAD_Gly3P_dh_N PF01210.18 EFE44941.1 - 0.052 13.2 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GDI PF00996.13 EFE44941.1 - 0.052 11.8 0.1 0.092 11.0 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor 3HCDH_N PF02737.13 EFE44941.1 - 0.16 11.6 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Mqo PF06039.10 EFE44941.1 - 0.24 9.5 0.1 0.42 8.7 0.0 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) PPR PF01535.15 EFE44942.1 - 4.1e-07 29.5 0.8 0.043 13.7 0.0 5.6 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.1 EFE44942.1 - 9.1e-07 28.6 0.9 0.0022 18.1 0.0 5.6 6 0 0 6 6 6 1 Pentatricopeptide repeat domain PPR_2 PF13041.1 EFE44942.1 - 0.00038 20.3 0.2 0.79 9.7 0.0 4.6 5 0 0 5 5 5 1 PPR repeat family PPR_1 PF12854.2 EFE44942.1 - 0.00097 18.5 0.0 2.2 7.8 0.0 3.6 4 0 0 4 4 4 2 PPR repeat TPR_19 PF14559.1 EFE44942.1 - 0.0025 18.1 0.1 1.3 9.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFE44942.1 - 0.029 14.9 0.1 10 7.0 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat YwhD PF08741.5 EFE44942.1 - 0.11 11.9 0.1 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 YwhD family MFS_1 PF07690.11 EFE44943.1 - 2.5e-26 92.2 15.3 2.4e-18 65.9 4.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF2269 PF10027.4 EFE44943.1 - 0.017 14.8 7.4 0.021 14.6 1.6 2.6 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) SPC12 PF06645.8 EFE44943.1 - 0.76 9.6 5.4 0.61 9.9 0.7 2.9 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Ferrochelatase PF00762.14 EFE44944.1 - 2.7e-67 226.9 0.0 3.1e-67 226.8 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Ku PF02735.11 EFE44945.1 - 7.2e-38 130.0 0.0 1.5e-37 128.9 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 EFE44945.1 - 1.6e-29 102.9 0.0 2.4e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain SAP PF02037.22 EFE44945.1 - 9.1e-14 50.5 0.0 2e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 SAP domain Ku_C PF03730.9 EFE44945.1 - 1.2e-13 51.3 3.6 4.6e-13 49.5 2.5 2.0 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm HeH PF12949.2 EFE44945.1 - 0.00065 19.1 0.2 0.0016 17.9 0.1 1.7 1 0 0 1 1 1 1 HeH/LEM domain Adap_comp_sub PF00928.16 EFE44946.1 - 3.9e-84 281.8 0.0 5.2e-84 281.4 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EFE44946.1 - 0.00022 20.9 0.2 0.00038 20.2 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Erf4 PF10256.4 EFE44947.1 - 7.4e-34 116.1 0.0 1.1e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family zf-C2H2 PF00096.21 EFE44949.1 - 2.6e-05 24.2 9.4 0.035 14.4 0.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE44949.1 - 0.0011 19.1 8.7 0.11 12.9 2.6 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger Ogr_Delta PF04606.7 EFE44949.1 - 0.0012 18.4 0.5 0.0023 17.5 0.3 1.5 1 0 0 1 1 1 1 Ogr/Delta-like zinc finger zf-H2C2_2 PF13465.1 EFE44949.1 - 0.0021 18.2 4.1 0.029 14.6 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_2 PF12756.2 EFE44949.1 - 0.0022 18.0 2.4 0.042 13.9 0.5 2.1 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-4CXXC_R1 PF10497.4 EFE44949.1 - 0.041 14.0 0.8 0.048 13.7 0.5 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C2H2_jaz PF12171.3 EFE44949.1 - 0.068 13.3 2.1 0.29 11.3 0.8 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFE44949.1 - 0.26 11.5 4.7 0.15 12.2 1.5 2.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Cyto_heme_lyase PF01265.12 EFE44950.1 - 4.3e-77 259.2 0.0 5.6e-77 258.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase APH PF01636.18 EFE44951.1 - 0.00018 21.3 0.1 0.00037 20.2 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family RNase_PH PF01138.16 EFE44952.1 - 2.5e-24 86.0 0.0 4.6e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Lactamase_B PF00753.22 EFE44953.1 - 1.5e-10 41.1 0.0 3.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFE44953.1 - 8e-05 22.2 0.0 0.00014 21.4 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain MFS_1 PF07690.11 EFE44955.1 - 9.3e-31 106.8 33.3 4e-29 101.4 20.0 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily tRNA-synt_2b PF00587.20 EFE44956.1 - 4.8e-21 75.1 0.1 7.5e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ProRS-C_1 PF09180.6 EFE44956.1 - 5e-18 64.7 4.7 1.2e-17 63.5 3.3 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.15 EFE44956.1 - 2.4e-12 46.6 0.0 8.4e-12 44.8 0.0 1.9 2 0 0 2 2 2 1 Anticodon binding domain Cpn60_TCP1 PF00118.19 EFE44957.1 - 3e-132 441.7 14.4 3.4e-132 441.5 10.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.27 EFE44958.1 - 5.1e-22 76.8 11.8 1.1e-06 28.2 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 EFE44958.1 - 0.00011 20.4 0.4 0.00028 19.1 0.3 1.6 1 1 0 1 1 1 1 Nucleoporin Nup120/160 S1 PF00575.18 EFE44959.1 - 2.1e-79 261.5 40.7 9.1e-17 60.9 0.2 11.6 11 0 0 11 11 11 10 S1 RNA binding domain TPR_16 PF13432.1 EFE44959.1 - 4.5e-05 24.0 0.0 3.7 8.3 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFE44959.1 - 6.7e-05 23.1 0.2 0.051 13.9 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFE44959.1 - 0.00066 20.0 0.0 0.87 10.4 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Suf PF05843.9 EFE44959.1 - 0.03 14.0 16.8 0.053 13.2 0.0 4.9 2 2 1 4 4 4 0 Suppressor of forked protein (Suf) PPR PF01535.15 EFE44959.1 - 0.12 12.4 0.0 32 4.7 0.0 3.2 2 1 0 2 2 2 0 PPR repeat SNAP-25 PF00835.14 EFE44959.1 - 1.2 9.9 11.6 1.2 9.9 1.7 3.6 3 0 0 3 3 3 0 SNAP-25 family Phage_lysozyme PF00959.14 EFE44961.1 - 1.4e-11 44.5 0.0 2.6e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme UreD PF01774.12 EFE44962.1 - 9.7e-52 175.4 0.0 1.9e-51 174.5 0.0 1.5 1 1 0 1 1 1 1 UreD urease accessory protein STAG PF08514.6 EFE44963.1 - 6.6e-38 129.0 0.3 2.9e-37 126.9 0.2 2.2 1 0 0 1 1 1 1 STAG domain HEAT_2 PF13646.1 EFE44963.1 - 0.0029 17.8 0.0 0.57 10.5 0.0 3.6 3 0 0 3 3 3 1 HEAT repeats DUF3573 PF12097.3 EFE44963.1 - 0.12 10.9 0.1 0.27 9.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF422 PF04240.7 EFE44963.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF422) GFA PF04828.9 EFE44964.1 - 7.1e-12 45.1 0.1 1.1e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_2 PF13240.1 EFE44964.1 - 3.9 7.0 5.9 0.68 9.4 0.6 2.3 3 0 0 3 3 3 0 zinc-ribbon domain Acatn PF13000.2 EFE44965.1 - 2.8e-147 491.5 23.2 9.4e-80 268.6 6.7 3.0 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 CENP-O PF09496.5 EFE44966.1 - 5.1e-25 87.5 0.0 8.4e-25 86.8 0.0 1.4 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component UBA_e1_thiolCys PF10585.4 EFE44969.1 - 0.082 12.3 0.1 0.16 11.4 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site DFP PF04127.10 EFE44970.1 - 5.5e-13 48.9 0.0 0.00023 20.8 0.0 3.2 2 1 1 3 3 3 3 DNA / pantothenate metabolism flavoprotein Polysacc_deac_1 PF01522.16 EFE44971.1 - 2.6e-13 49.6 0.0 4.6e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.4 EFE44971.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) DEAD PF00270.24 EFE44972.1 - 3.2e-41 140.6 0.0 5.2e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFE44972.1 - 1.9e-21 75.7 0.1 3.8e-21 74.7 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFE44972.1 - 2.7e-05 23.0 0.0 4.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1253 PF06862.7 EFE44972.1 - 0.027 12.9 0.0 1.4 7.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) ResIII PF04851.10 EFE44972.1 - 0.036 13.8 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit GDA1_CD39 PF01150.12 EFE44972.1 - 0.15 10.4 0.0 0.26 9.7 0.0 1.2 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family Glyoxal_oxid_N PF07250.6 EFE44973.1 - 1.7e-40 138.6 0.0 4.4e-39 134.0 0.0 2.4 2 0 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 EFE44973.1 - 1.2e-22 79.8 0.2 2.2e-22 78.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Chitin_bind_1 PF00187.14 EFE44973.1 - 0.00016 21.5 21.1 0.00016 21.5 14.6 2.3 2 0 0 2 2 2 1 Chitin recognition protein Fumble PF03630.9 EFE44974.1 - 1.8e-134 447.9 2.2 2e-133 444.4 1.5 1.9 1 1 0 1 1 1 1 Fumble GPI2 PF06432.6 EFE44975.1 - 2.7e-115 384.5 6.3 3.4e-115 384.2 4.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Miff PF05644.6 EFE44976.1 - 0.0039 16.8 5.5 0.0039 16.8 3.8 1.7 1 1 1 2 2 2 1 Mitochondrial and peroxisomal fission factor Mff eIF-3c_N PF05470.7 EFE44976.1 - 0.095 10.7 7.4 0.12 10.4 5.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF1618 PF07762.9 EFE44976.1 - 0.12 12.6 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1618) ORC6 PF05460.8 EFE44976.1 - 0.27 10.3 11.1 0.32 10.0 7.7 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF1510 PF07423.6 EFE44976.1 - 0.66 9.3 12.9 3.1 7.1 6.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Ycf1 PF05758.7 EFE44976.1 - 1.2 6.7 9.9 1.5 6.4 6.9 1.1 1 0 0 1 1 1 0 Ycf1 Pox_Ag35 PF03286.9 EFE44976.1 - 3.2 7.2 18.8 0.54 9.7 9.4 1.9 1 1 1 2 2 2 0 Pox virus Ag35 surface protein AIF_C PF14721.1 EFE44976.1 - 4.1 7.6 8.9 54 4.0 4.7 2.4 2 1 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Red1 PF07964.6 EFE44976.1 - 6.1 4.8 13.6 4.7 5.2 8.6 1.3 1 1 0 1 1 1 0 Rec10 / Red1 Hid1 PF12722.2 EFE44976.1 - 6.4 4.3 8.8 7.5 4.0 6.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Glyco_hydro_18 PF00704.23 EFE44978.1 - 5.1e-19 68.9 1.2 4.3e-18 65.8 0.0 2.2 1 1 1 2 2 2 1 Glycosyl hydrolases family 18 AA_permease_2 PF13520.1 EFE44980.1 - 6.8e-37 127.0 58.0 7e-36 123.6 40.2 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE44980.1 - 1.6e-17 63.0 52.2 1.4e-15 56.5 36.2 2.0 1 1 0 1 1 1 1 Amino acid permease NPCC PF08058.6 EFE44981.1 - 0.16 11.8 0.1 0.23 11.3 0.1 1.2 1 0 0 1 1 1 0 Nuclear pore complex component AA_permease_2 PF13520.1 EFE44982.1 - 1.6e-42 145.5 47.1 1.9e-42 145.2 32.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE44982.1 - 7.2e-29 100.4 43.2 9.9e-29 99.9 29.9 1.0 1 0 0 1 1 1 1 Amino acid permease Dynamin_N PF00350.18 EFE44983.1 - 5.6e-25 88.0 0.0 1.5e-24 86.7 0.0 1.8 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFE44983.1 - 4.4e-05 22.3 0.4 0.1 11.3 0.1 2.8 3 1 0 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.18 EFE44983.1 - 0.0018 18.2 0.0 0.007 16.3 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.13 EFE44983.1 - 0.024 14.5 3.9 0.49 10.3 0.1 4.1 4 1 0 4 4 4 0 Dynamin GTPase effector domain Miro PF08477.8 EFE44983.1 - 0.079 13.4 0.0 0.25 11.8 0.0 2.0 1 0 0 1 1 1 0 Miro-like protein Syntaxin_2 PF14523.1 EFE44983.1 - 0.57 10.2 3.6 0.49 10.4 0.1 2.6 3 0 0 3 3 3 0 Syntaxin-like protein 5_nucleotid_C PF02872.13 EFE44987.1 - 3.6e-31 108.2 0.0 7.5e-30 103.9 0.0 2.4 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 EFE44987.1 - 0.00013 21.4 0.2 0.00026 20.4 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FG-GAP PF01839.18 EFE44987.1 - 0.39 10.4 3.9 1.3 8.7 2.7 1.9 1 0 0 1 1 1 0 FG-GAP repeat TMEM154 PF15102.1 EFE44988.1 - 0.056 13.1 0.0 0.063 12.9 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family Protocadherin PF08374.6 EFE44988.1 - 0.08 12.5 0.0 0.092 12.3 0.0 1.1 1 0 0 1 1 1 0 Protocadherin Kinetochor_Ybp2 PF08568.5 EFE44988.1 - 0.092 10.9 0.0 0.098 10.8 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin DUF1049 PF06305.6 EFE44988.1 - 0.12 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Aldedh PF00171.17 EFE44989.1 - 2.9e-146 487.4 0.1 3.2e-146 487.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DMRL_synthase PF00885.14 EFE44989.1 - 0.11 12.2 0.0 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 6,7-dimethyl-8-ribityllumazine synthase DUF3008 PF11450.3 EFE44991.1 - 0.18 11.9 0.1 0.33 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknwon function (DUF3008) MIP-T3 PF10243.4 EFE44992.1 - 0.36 9.2 9.8 0.46 8.8 6.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Gln-synt_C PF00120.19 EFE44994.1 - 1.1e-42 146.0 0.0 2.1e-42 145.0 0.0 1.5 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.9 EFE44994.1 - 4.4e-27 95.3 0.0 8.5e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.11 EFE44995.1 - 7.7e-35 120.2 24.5 7.7e-35 120.2 17.0 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFE44995.1 - 2.1e-12 46.3 12.5 2.1e-12 46.3 8.7 2.7 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 EFE44995.1 - 0.0011 17.2 3.7 0.0018 16.5 2.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UPF0016 PF01169.14 EFE44998.1 - 1.1e-39 134.4 25.4 1.7e-21 76.1 5.1 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF2208 PF09973.4 EFE44998.1 - 0.0019 17.4 0.1 0.0035 16.6 0.1 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2208) DUF4614 PF15391.1 EFE44998.1 - 0.67 9.7 0.0 0.67 9.7 0.0 2.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4614) APH PF01636.18 EFE44999.1 - 1e-13 51.6 0.1 3.8e-13 49.7 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE44999.1 - 0.00053 19.6 0.0 0.00091 18.8 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 EFE44999.1 - 0.0053 16.1 0.0 0.16 11.2 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Myb_DNA-binding PF00249.26 EFE45000.1 - 0.00077 19.4 0.1 0.0019 18.2 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Annexin PF00191.15 EFE45001.1 - 1.1e-13 50.9 6.6 0.0017 18.2 0.1 4.6 4 1 0 4 4 4 4 Annexin Ribosomal_L21e PF01157.13 EFE45002.1 - 2.4e-26 91.3 3.7 2.4e-26 91.3 2.5 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e Ter PF05472.6 EFE45002.1 - 0.0085 15.2 0.5 0.01 14.9 0.4 1.1 1 0 0 1 1 1 1 DNA replication terminus site-binding protein (Ter protein) Nexin_C PF08628.7 EFE45002.1 - 0.12 12.4 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Sorting nexin C terminal Ribosomal_S4 PF00163.14 EFE45003.1 - 2.6e-22 78.9 1.0 6.3e-22 77.7 0.7 1.6 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 EFE45003.1 - 1.4e-12 46.7 1.5 1.4e-12 46.7 1.1 2.3 3 0 0 3 3 3 1 S4 domain Bacillus_HBL PF05791.6 EFE45004.1 - 0.035 13.4 4.2 0.051 12.9 0.2 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF4618 PF15397.1 EFE45004.1 - 0.058 12.7 10.9 0.091 12.0 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) zf-ZPR1 PF03367.8 EFE45004.1 - 0.12 11.5 1.5 0.24 10.5 1.0 1.5 1 0 0 1 1 1 0 ZPR1 zinc-finger domain DUF1216 PF06746.6 EFE45004.1 - 0.33 10.7 2.9 0.17 11.6 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) Atg14 PF10186.4 EFE45004.1 - 0.56 9.0 13.7 0.085 11.7 3.5 2.1 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 BLOC1_2 PF10046.4 EFE45004.1 - 0.78 9.9 7.8 0.32 11.1 0.6 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Exonuc_VII_L PF02601.10 EFE45004.1 - 0.92 8.6 12.7 1.4 8.0 8.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DivIC PF04977.10 EFE45004.1 - 1 8.9 17.6 3.3 7.2 0.1 3.9 4 0 0 4 4 4 0 Septum formation initiator AAA_13 PF13166.1 EFE45004.1 - 1.5 7.1 10.9 2.7 6.3 7.3 1.5 1 1 0 1 1 1 0 AAA domain Prefoldin PF02996.12 EFE45004.1 - 2.6 7.7 13.8 2.7 7.6 0.2 3.7 2 1 1 4 4 4 0 Prefoldin subunit ORF6C PF10552.4 EFE45004.1 - 3.4 7.4 7.9 7 6.4 0.1 2.7 3 0 0 3 3 3 0 ORF6C domain FlaC_arch PF05377.6 EFE45004.1 - 4.4 7.2 9.2 7.1 6.6 0.0 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Fmp27_WPPW PF10359.4 EFE45004.1 - 4.5 5.5 10.8 0.25 9.7 2.4 1.9 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF4407 PF14362.1 EFE45004.1 - 4.5 6.1 12.8 11 4.8 8.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.6 EFE45004.1 - 5.2 5.6 19.2 0.41 9.2 6.5 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.7 EFE45004.1 - 7.2 6.4 8.7 2.6e+02 1.3 6.1 2.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Microtub_assoc PF07989.6 EFE45004.1 - 9.2 6.1 12.2 0.75 9.6 2.1 3.7 3 2 1 4 4 4 0 Microtubule associated FliT PF05400.8 EFE45004.1 - 10 6.6 18.8 8.3 6.9 1.0 4.1 4 0 0 4 4 4 0 Flagellar protein FliT Amidoligase_2 PF12224.3 EFE45006.1 - 1e-08 35.1 0.0 0.002 17.8 0.0 2.8 3 0 0 3 3 3 2 Putative amidoligase enzyme Peptidase_C12 PF01088.16 EFE45007.1 - 0.24 10.5 1.1 0.25 10.4 0.8 1.0 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF946 PF06101.6 EFE45008.1 - 0.056 11.4 0.2 6.2 4.6 0.1 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF946) Nucleoplasmin PF03066.10 EFE45009.1 - 0.071 12.6 13.7 0.075 12.5 9.5 1.1 1 0 0 1 1 1 0 Nucleoplasmin BSP_II PF05432.6 EFE45009.1 - 0.13 11.5 17.7 0.13 11.4 12.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RXT2_N PF08595.6 EFE45009.1 - 0.16 11.7 6.4 0.17 11.7 4.4 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal Pox_Ag35 PF03286.9 EFE45009.1 - 0.24 10.8 11.4 0.28 10.6 7.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RNA_pol_3_Rpc31 PF11705.3 EFE45009.1 - 0.29 11.0 15.2 0.31 10.9 10.6 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RecT PF03837.9 EFE45009.1 - 0.3 10.3 2.9 0.34 10.1 2.0 1.1 1 0 0 1 1 1 0 RecT family NOA36 PF06524.7 EFE45009.1 - 0.47 9.6 5.9 0.5 9.5 4.1 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.4 EFE45009.1 - 0.61 8.7 15.1 0.7 8.5 10.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CobT PF06213.7 EFE45009.1 - 0.67 9.0 12.6 0.69 9.0 8.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Daxx PF03344.10 EFE45009.1 - 0.75 8.2 16.2 0.82 8.0 11.2 1.0 1 0 0 1 1 1 0 Daxx Family Sporozoite_P67 PF05642.6 EFE45009.1 - 0.8 7.4 8.7 0.82 7.4 6.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Sigma70_ner PF04546.8 EFE45009.1 - 0.84 9.2 11.3 0.83 9.2 7.8 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4366 PF14283.1 EFE45009.1 - 0.85 9.0 8.1 0.92 8.8 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Retinal PF15449.1 EFE45009.1 - 1 6.9 7.8 0.94 7.0 5.4 1.0 1 0 0 1 1 1 0 Retinal protein Nop14 PF04147.7 EFE45009.1 - 1.3 6.8 14.3 1.3 6.8 9.9 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2890 PF11081.3 EFE45009.1 - 1.5 8.8 12.5 1.5 8.8 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) TRAP_alpha PF03896.11 EFE45009.1 - 1.7 7.6 9.0 1.7 7.5 6.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Voldacs PF03517.8 EFE45009.1 - 1.7 8.4 5.6 1.7 8.5 3.9 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling CDC45 PF02724.9 EFE45009.1 - 2 6.3 11.5 1.9 6.4 7.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Myc_N PF01056.13 EFE45009.1 - 2.3 7.2 10.7 2.7 7.0 7.4 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Vfa1 PF08432.5 EFE45009.1 - 2.8 7.9 11.0 3 7.8 7.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 VID27 PF08553.5 EFE45009.1 - 4 5.5 10.5 3.8 5.6 7.3 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein RNA_pol_Rpc4 PF05132.9 EFE45009.1 - 4 7.4 7.4 4.6 7.2 5.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF1510 PF07423.6 EFE45009.1 - 5.2 6.3 14.9 5.7 6.2 10.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PPP4R2 PF09184.6 EFE45009.1 - 5.6 6.4 13.9 5.7 6.4 9.6 1.1 1 0 0 1 1 1 0 PPP4R2 RNase_H2-Ydr279 PF09468.5 EFE45009.1 - 8.3 5.5 7.2 8.2 5.5 5.0 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Nucleo_P87 PF07267.6 EFE45009.1 - 8.9 4.8 10.2 9.7 4.7 7.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Spore_coat_CotO PF14153.1 EFE45009.1 - 9 5.6 15.2 9.7 5.5 10.5 1.0 1 0 0 1 1 1 0 Spore coat protein CotO Septin PF00735.13 EFE45010.1 - 3.2e-33 114.9 0.0 9.4e-14 51.0 0.0 3.2 3 0 0 3 3 3 3 Septin Miro PF08477.8 EFE45010.1 - 0.021 15.3 0.0 0.065 13.7 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein AAA_23 PF13476.1 EFE45010.1 - 0.05 13.9 0.3 0.2 11.9 0.0 2.0 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 EFE45010.1 - 0.072 12.9 0.8 0.59 9.9 0.0 2.7 2 0 0 2 2 2 0 Dynamin family Asp-B-Hydro_N PF05279.6 EFE45012.1 - 0.084 12.7 8.8 0.093 12.5 6.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region OATP PF03137.15 EFE45012.1 - 0.14 10.1 0.5 0.2 9.6 0.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3584 PF12128.3 EFE45012.1 - 0.36 8.1 7.7 0.44 7.8 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Sigma70_ner PF04546.8 EFE45012.1 - 1.5 8.4 8.8 0.063 12.8 1.8 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region P5-ATPase PF12409.3 EFE45013.1 - 4.6e-40 136.1 0.0 9.7e-40 135.1 0.0 1.5 1 0 0 1 1 1 1 P5-type ATPase cation transporter Cation_ATPase_N PF00690.21 EFE45013.1 - 0.053 12.9 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus HAD PF12710.2 EFE45014.1 - 3.5e-19 69.7 0.0 6.4e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFE45014.1 - 2e-12 47.9 0.1 9.8e-11 42.4 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFE45014.1 - 0.00076 19.3 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 EFE45014.1 - 0.083 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 E1-E2 ATPase HAD PF12710.2 EFE45015.1 - 5.4e-08 33.2 0.0 8.6e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFE45015.1 - 0.0002 21.8 0.1 0.00029 21.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFE45015.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase G_glu_transpept PF01019.16 EFE45016.1 - 1.2e-104 350.6 0.0 3.9e-104 348.9 0.0 1.7 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase UPF0181 PF03701.9 EFE45016.1 - 0.17 11.2 0.2 17 4.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) Pkinase PF00069.20 EFE45017.1 - 7.8e-13 48.1 0.0 2.4e-05 23.5 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Totivirus_coat PF05518.6 EFE45017.1 - 0.67 7.7 2.3 0.8 7.4 1.6 1.2 1 0 0 1 1 1 0 Totivirus coat protein YkyA PF10368.4 EFE45018.1 - 0.67 9.2 7.5 0.96 8.7 5.2 1.3 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein IncA PF04156.9 EFE45018.1 - 2 7.9 9.6 2.8 7.4 6.7 1.3 1 0 0 1 1 1 0 IncA protein DUF2422 PF10337.4 EFE45018.1 - 3.5 6.3 9.4 1.1 7.9 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2422) 2-Hacid_dh_C PF02826.14 EFE45019.1 - 2e-48 163.8 0.0 3.2e-48 163.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFE45019.1 - 9e-34 115.8 0.0 1.5e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFE45019.1 - 8.5e-05 22.4 0.3 0.00023 21.0 0.2 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.20 EFE45019.1 - 0.00023 20.5 0.2 0.00067 19.0 0.0 1.9 2 0 0 2 2 2 1 ACT domain AdoHcyase_NAD PF00670.16 EFE45019.1 - 0.0067 16.2 0.1 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.7 EFE45019.1 - 0.016 14.5 0.2 0.038 13.3 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain 3HCDH_N PF02737.13 EFE45019.1 - 0.12 12.0 1.4 1.2 8.7 0.3 2.6 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain tRNA-synt_2b PF00587.20 EFE45020.1 - 2.6e-24 85.7 0.0 4.3e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EFE45020.1 - 3.4e-19 68.8 4.3 3.4e-19 68.8 3.0 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Mnd1 PF03962.10 EFE45020.1 - 0.015 14.9 2.1 0.035 13.7 1.5 1.6 1 0 0 1 1 1 0 Mnd1 family DUF4337 PF14235.1 EFE45020.1 - 0.94 9.3 3.6 1.9 8.3 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Ras PF00071.17 EFE45022.1 - 1e-42 145.3 0.1 1.1e-42 145.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFE45022.1 - 2.9e-13 50.3 0.0 4.1e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFE45022.1 - 7.6e-06 25.2 0.0 8.4e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFE45022.1 - 5.1e-05 22.7 0.1 0.0001 21.8 0.0 1.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EFE45022.1 - 0.0031 17.4 0.1 0.005 16.7 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase SP_C-Propep PF08999.5 EFE45024.1 - 0.028 13.9 5.7 0.028 13.8 4.0 1.1 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Shisa PF13908.1 EFE45024.1 - 0.059 13.5 4.0 0.06 13.5 2.7 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Baculo_11_kDa PF06143.6 EFE45024.1 - 0.16 11.3 1.8 0.16 11.3 1.2 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family EphA2_TM PF14575.1 EFE45024.1 - 0.32 11.4 5.3 0.39 11.1 3.7 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3165 PF11364.3 EFE45024.1 - 0.39 10.8 4.7 0.48 10.5 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3165) m04gp34like PF12216.3 EFE45024.1 - 0.43 9.8 2.6 0.39 10.0 1.8 1.0 1 0 0 1 1 1 0 Immune evasion protein DUF4342 PF14242.1 EFE45024.1 - 0.76 9.5 9.7 0.88 9.3 6.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) Endomucin PF07010.7 EFE45024.1 - 1.4 8.1 3.6 1.5 8.0 2.5 1.0 1 0 0 1 1 1 0 Endomucin IncA PF04156.9 EFE45024.1 - 1.9 8.0 3.8 2.1 7.8 2.6 1.0 1 0 0 1 1 1 0 IncA protein HemY_N PF07219.8 EFE45024.1 - 2.5 7.6 4.8 2.8 7.5 3.3 1.1 1 0 0 1 1 1 0 HemY protein N-terminus Baculo_PEP_C PF04513.7 EFE45026.1 - 0.00015 21.5 12.3 0.0014 18.5 2.6 2.1 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Transcrip_act PF04949.8 EFE45026.1 - 0.00041 20.0 2.3 0.27 10.8 0.0 2.2 1 1 1 2 2 2 2 Transcriptional activator Reo_sigmaC PF04582.7 EFE45026.1 - 0.00076 18.7 2.0 0.039 13.1 1.0 2.0 1 1 1 2 2 2 1 Reovirus sigma C capsid protein GAS PF13851.1 EFE45026.1 - 0.00076 18.7 2.1 0.0011 18.2 1.4 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.7 EFE45026.1 - 0.0012 18.6 1.9 0.0023 17.6 1.3 1.5 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.7 EFE45026.1 - 0.0016 18.6 5.2 0.012 15.8 1.9 2.9 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein EzrA PF06160.7 EFE45026.1 - 0.0027 15.9 3.2 0.0027 15.9 0.9 1.8 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA AAA_13 PF13166.1 EFE45026.1 - 0.0031 16.0 3.8 0.004 15.7 2.6 1.2 1 0 0 1 1 1 1 AAA domain P4Ha_N PF08336.6 EFE45026.1 - 0.0038 17.0 1.8 0.82 9.4 0.1 3.3 2 1 2 4 4 3 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region COG6 PF06419.6 EFE45026.1 - 0.0043 15.2 1.7 0.0065 14.6 1.2 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 FlaC_arch PF05377.6 EFE45026.1 - 0.0058 16.4 5.3 0.38 10.6 0.7 3.3 1 1 2 3 3 3 1 Flagella accessory protein C (FlaC) WEMBL PF05701.6 EFE45026.1 - 0.0065 14.9 0.7 0.0086 14.5 0.5 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light Lectin_N PF03954.9 EFE45026.1 - 0.0078 15.6 2.4 0.047 13.0 0.6 2.3 1 1 2 3 3 3 2 Hepatic lectin, N-terminal domain Filament PF00038.16 EFE45026.1 - 0.0096 15.4 2.2 0.012 15.0 0.9 1.4 1 1 0 1 1 1 1 Intermediate filament protein MscS_porin PF12795.2 EFE45026.1 - 0.0099 15.2 1.9 0.015 14.5 1.3 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Syntaxin PF00804.20 EFE45026.1 - 0.016 15.3 6.7 0.043 13.9 3.4 2.2 1 1 1 2 2 2 0 Syntaxin DUF677 PF05055.7 EFE45026.1 - 0.016 13.9 2.6 0.035 12.7 1.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF677) DUF3584 PF12128.3 EFE45026.1 - 0.016 12.5 2.3 0.021 12.2 1.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ISG65-75 PF11727.3 EFE45026.1 - 0.017 14.1 3.8 0.02 13.9 1.7 1.6 1 1 1 2 2 2 0 Invariant surface glycoprotein TACC PF05010.9 EFE45026.1 - 0.018 14.7 1.6 0.069 12.9 1.1 1.8 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) Atg14 PF10186.4 EFE45026.1 - 0.022 13.7 1.9 0.037 12.9 1.3 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Nup54 PF13874.1 EFE45026.1 - 0.026 14.1 1.1 0.17 11.5 0.8 2.1 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 PspA_IM30 PF04012.7 EFE45026.1 - 0.028 13.7 1.4 1.5 8.1 0.2 2.0 1 1 1 2 2 2 0 PspA/IM30 family DUF1411 PF07199.6 EFE45026.1 - 0.03 13.7 0.4 0.043 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) Transposase_22 PF02994.9 EFE45026.1 - 0.033 12.6 2.1 0.048 12.1 1.5 1.3 1 0 0 1 1 1 0 L1 transposable element Spc7 PF08317.6 EFE45026.1 - 0.04 12.5 4.4 0.042 12.5 1.7 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein RmuC PF02646.11 EFE45026.1 - 0.041 12.7 3.0 0.76 8.5 0.5 2.7 1 1 2 3 3 3 0 RmuC family LXG PF04740.7 EFE45026.1 - 0.043 13.6 5.2 1.8 8.2 0.0 2.2 1 1 1 2 2 2 0 LXG domain of WXG superfamily CENP-F_leu_zip PF10473.4 EFE45026.1 - 0.044 13.6 2.8 0.069 13.0 2.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.7 EFE45026.1 - 0.049 13.3 6.0 0.16 11.7 1.5 2.2 1 1 2 3 3 3 0 Laminin Domain II IncA PF04156.9 EFE45026.1 - 0.049 13.2 3.7 0.13 11.8 2.5 1.9 1 1 0 1 1 1 0 IncA protein Tropomyosin_1 PF12718.2 EFE45026.1 - 0.055 13.3 2.7 1.7 8.4 0.0 2.1 1 1 1 2 2 2 0 Tropomyosin like Fib_alpha PF08702.5 EFE45026.1 - 0.059 13.4 6.2 0.17 11.9 3.5 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family APG17 PF04108.7 EFE45026.1 - 0.06 12.1 2.7 0.075 11.8 1.5 1.3 1 1 0 1 1 1 0 Autophagy protein Apg17 Med9 PF07544.8 EFE45026.1 - 0.061 13.0 3.4 1.3 8.8 0.3 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 UPF0184 PF03670.8 EFE45026.1 - 0.064 13.4 0.8 1.3 9.2 0.1 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0184) Spectrin PF00435.16 EFE45026.1 - 0.07 13.4 2.1 4.9 7.5 0.4 2.9 1 1 0 2 2 2 0 Spectrin repeat Myosin_tail_1 PF01576.14 EFE45026.1 - 0.07 10.8 2.6 0.087 10.5 1.8 1.0 1 0 0 1 1 1 0 Myosin tail MCPsignal PF00015.16 EFE45026.1 - 0.077 12.5 3.4 0.12 11.9 1.6 1.7 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.7 EFE45026.1 - 0.079 12.7 5.3 0.36 10.6 1.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cortex-I_coil PF09304.5 EFE45026.1 - 0.087 12.8 3.3 1.8 8.6 0.5 2.4 1 1 1 2 2 2 0 Cortexillin I, coiled coil TelA PF05816.6 EFE45026.1 - 0.093 11.4 2.5 5.8 5.5 0.6 2.5 1 1 1 3 3 3 0 Toxic anion resistance protein (TelA) bZIP_1 PF00170.16 EFE45026.1 - 0.094 12.6 0.4 1.6 8.7 0.0 2.6 2 1 0 2 2 2 0 bZIP transcription factor ADIP PF11559.3 EFE45026.1 - 0.097 12.5 3.4 0.6 9.9 2.4 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4254 PF14063.1 EFE45026.1 - 0.11 12.1 0.5 2.6 7.6 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4254) Lebercilin PF15619.1 EFE45026.1 - 0.13 11.6 1.1 0.26 10.7 0.7 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease PUB PF09409.5 EFE45026.1 - 0.14 11.9 0.7 0.56 10.0 0.3 2.1 1 1 1 2 2 2 0 PUB domain Prefoldin_2 PF01920.15 EFE45026.1 - 0.14 11.8 3.5 4.6 7.0 1.3 3.0 2 1 0 2 2 2 0 Prefoldin subunit DUF2317 PF10079.4 EFE45026.1 - 0.15 10.6 0.6 0.21 10.1 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) Allexi_40kDa PF05549.6 EFE45026.1 - 0.16 11.2 3.1 0.32 10.2 1.9 1.6 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF4164 PF13747.1 EFE45026.1 - 0.17 12.0 1.9 0.91 9.7 1.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) DUF4407 PF14362.1 EFE45026.1 - 0.18 10.7 0.9 0.28 10.0 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FliJ PF02050.11 EFE45026.1 - 0.21 11.6 0.8 2.2 8.3 0.3 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein Phasin PF05597.6 EFE45026.1 - 0.24 11.1 3.8 3.4 7.4 1.1 2.4 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) ATG16 PF08614.6 EFE45026.1 - 0.27 11.0 4.0 0.27 11.0 1.8 1.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF948 PF06103.6 EFE45026.1 - 0.28 11.0 4.2 0.6 9.9 1.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Mer2 PF09074.5 EFE45026.1 - 0.31 10.9 5.8 1.8 8.4 0.4 2.3 1 1 1 2 2 2 0 Mer2 DUF3450 PF11932.3 EFE45026.1 - 0.31 10.2 2.5 1.6 7.9 0.6 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin_2 PF14523.1 EFE45026.1 - 0.32 11.0 4.5 0.28 11.2 1.8 1.9 2 0 0 2 2 1 0 Syntaxin-like protein BLOC1_2 PF10046.4 EFE45026.1 - 0.42 10.7 5.4 11 6.2 0.1 2.7 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF812 PF05667.6 EFE45026.1 - 0.43 9.0 5.4 0.31 9.5 2.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) HsbA PF12296.3 EFE45026.1 - 0.6 9.9 3.8 9.1 6.1 2.6 2.7 1 1 0 1 1 1 0 Hydrophobic surface binding protein A GP41 PF00517.12 EFE45026.1 - 1.3 8.5 5.8 16 4.9 0.0 2.8 1 1 2 3 3 3 0 Retroviral envelope protein Vps51 PF08700.6 EFE45026.1 - 1.6 8.6 4.3 7.8 6.4 0.2 2.6 2 1 1 3 3 2 0 Vps51/Vps67 DUF16 PF01519.11 EFE45026.1 - 2.9 8.1 7.2 0.9 9.7 1.2 2.3 1 1 0 2 2 2 0 Protein of unknown function DUF16 SBF PF01758.11 EFE45028.1 - 0.016 14.5 0.7 0.018 14.4 0.5 1.0 1 0 0 1 1 1 0 Sodium Bile acid symporter family VIT1 PF01988.14 EFE45028.1 - 0.072 12.5 3.5 0.09 12.2 2.5 1.1 1 0 0 1 1 1 0 VIT family DUF2207 PF09972.4 EFE45028.1 - 1 7.8 4.6 1.1 7.8 3.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HORMA PF02301.13 EFE45029.1 - 6.8e-29 100.8 0.0 7.6e-29 100.6 0.0 1.0 1 0 0 1 1 1 1 HORMA domain FlaG PF03646.10 EFE45029.1 - 0.52 10.4 3.1 5.9 7.0 0.7 2.2 2 0 0 2 2 2 0 FlaG protein GTP_EFTU PF00009.22 EFE45030.1 - 4.5e-49 166.4 0.0 7.1e-49 165.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 EFE45030.1 - 4.4e-40 135.9 3.9 6.9e-40 135.3 2.7 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 EFE45030.1 - 5.9e-20 70.9 0.0 1.1e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus Ras PF00071.17 EFE45030.1 - 7e-06 25.5 0.0 5.1e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.18 EFE45030.1 - 5.5e-05 23.0 0.1 0.00016 21.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 EFE45030.1 - 0.00014 21.8 0.8 0.00028 20.9 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EFE45030.1 - 0.00058 19.6 0.0 0.0015 18.3 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.5 EFE45030.1 - 0.0051 16.0 0.0 0.013 14.7 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit p450 PF00067.17 EFE45031.1 - 6.3e-31 107.3 0.0 1.1e-30 106.5 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_11 PF08241.7 EFE45032.1 - 6.5e-10 39.3 0.0 1e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE45032.1 - 1.6e-08 35.1 0.0 3.3e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE45032.1 - 1.6e-08 34.9 0.0 2.7e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE45032.1 - 5e-08 33.2 0.0 8.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE45032.1 - 3e-06 26.9 0.0 7.5e-06 25.6 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFE45032.1 - 3.5e-05 23.5 0.1 6.9e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFE45032.1 - 0.0011 19.0 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.7 EFE45032.1 - 0.039 13.2 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase MTS PF05175.9 EFE45032.1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DUF3040 PF11239.3 EFE45033.1 - 0.0086 16.1 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3040) FAD_binding_4 PF01565.18 EFE45035.1 - 1.6e-24 85.9 3.5 2.4e-24 85.3 2.4 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFE45035.1 - 1.2e-09 37.8 0.0 2.4e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Peptidase_S64 PF08192.6 EFE45036.1 - 1.7e-05 23.3 0.6 0.0035 15.7 0.1 2.1 2 0 0 2 2 2 2 Peptidase family S64 Trypsin_2 PF13365.1 EFE45036.1 - 9e-05 22.4 0.0 0.00019 21.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.10 EFE45036.1 - 0.003 17.0 0.0 0.0063 16.0 0.0 1.5 1 0 0 1 1 1 1 Hepatitis C virus NS3 protease ECH PF00378.15 EFE45037.1 - 2.1e-39 135.1 0.2 3.1e-39 134.5 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family 2OG-FeII_Oxy_2 PF13532.1 EFE45038.1 - 9.3e-25 87.5 0.0 1.7e-24 86.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.15 EFE45038.1 - 2.3e-21 76.4 0.0 9e-15 55.0 0.0 2.3 2 0 0 2 2 2 2 Isochorismatase family GST_N_3 PF13417.1 EFE45038.1 - 0.00023 21.3 0.0 0.0013 18.9 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFE45038.1 - 0.0013 18.8 0.0 0.011 15.8 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.8 EFE45038.1 - 0.017 14.6 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_N_2 PF13409.1 EFE45038.1 - 0.036 14.0 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain DUF4175 PF13779.1 EFE45038.1 - 0.1 10.2 0.0 0.16 9.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) IlvN PF07991.7 EFE45039.1 - 1.7e-44 151.1 0.0 2.4e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvC PF01450.14 EFE45039.1 - 1.6e-42 144.8 0.0 2.6e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.10 EFE45039.1 - 0.018 14.8 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Amidoligase_2 PF12224.3 EFE45040.1 - 3.3e-17 62.9 0.0 4.1e-16 59.3 0.0 2.0 1 1 0 1 1 1 1 Putative amidoligase enzyme AIG2 PF06094.7 EFE45040.1 - 0.0001 22.7 0.0 0.00021 21.7 0.0 1.5 1 0 0 1 1 1 1 AIG2-like family PALP PF00291.20 EFE45041.1 - 9e-59 199.1 0.1 1.3e-58 198.7 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme tify PF06200.9 EFE45041.1 - 0.04 13.1 0.3 0.59 9.4 0.0 2.3 2 0 0 2 2 2 0 tify domain Hexose_dehydrat PF03559.9 EFE45042.1 - 0.039 12.9 0.0 0.079 11.9 0.0 1.4 2 0 0 2 2 2 0 NDP-hexose 2,3-dehydratase Rad51 PF08423.6 EFE45042.1 - 0.15 10.9 0.0 0.29 10.0 0.0 1.4 1 0 0 1 1 1 0 Rad51 TAF8_C PF10406.4 EFE45043.1 - 2.7e-18 65.7 0.6 6.1e-18 64.6 0.4 1.6 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term DUF2695 PF10905.3 EFE45043.1 - 0.0054 16.4 0.0 0.014 15.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2695) Bromo_TP PF07524.8 EFE45043.1 - 0.02 14.6 0.1 0.052 13.2 0.0 1.7 2 0 0 2 2 2 0 Bromodomain associated UQ_con PF00179.21 EFE45044.1 - 4.9e-35 120.0 0.0 6.3e-35 119.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFE45044.1 - 0.046 13.4 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Chitin_synth_1 PF01644.12 EFE45045.1 - 1.4e-68 229.8 0.0 2e-68 229.3 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EFE45045.1 - 7.3e-28 96.0 0.0 1.3e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EFE45045.1 - 9.5e-24 83.6 0.0 9.7e-19 67.1 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 EFE45045.1 - 1.6e-11 44.3 0.1 1.6e-11 44.3 0.1 3.4 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFE45045.1 - 7.6e-07 29.1 0.0 2.8e-06 27.3 0.0 1.9 3 0 0 3 3 3 1 Glycosyltransferase like family 2 AMP-binding PF00501.23 EFE45046.1 - 1.4e-49 168.6 0.0 2e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Opy2 PF09463.5 EFE45047.1 - 1.8e-08 34.3 20.0 3.2e-08 33.5 13.9 1.4 1 0 0 1 1 1 1 Opy2 protein SKG6 PF08693.5 EFE45047.1 - 0.0006 19.0 0.1 0.0006 19.0 0.1 2.3 2 0 0 2 2 2 1 Transmembrane alpha-helix domain MAPEG PF01124.13 EFE45047.1 - 0.088 12.4 0.1 0.22 11.1 0.0 1.6 2 0 0 2 2 2 0 MAPEG family Methyltransf_23 PF13489.1 EFE45048.1 - 0.00011 21.9 0.0 0.00018 21.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFE45048.1 - 0.0023 18.3 0.0 0.0054 17.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFE45048.1 - 0.023 14.3 0.0 1.9 8.0 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain CheR PF01739.13 EFE45048.1 - 0.026 13.7 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain TehB PF03848.9 EFE45048.1 - 0.067 12.3 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB HET PF06985.6 EFE45049.1 - 3.1e-22 79.2 9.0 1.1e-19 71.0 1.9 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Pox_Ag35 PF03286.9 EFE45051.1 - 0.00065 19.2 11.6 0.00068 19.2 8.0 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein DUF1510 PF07423.6 EFE45051.1 - 0.018 14.3 13.6 0.02 14.2 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Paf1 PF03985.8 EFE45051.1 - 0.019 13.6 22.0 0.023 13.4 15.3 1.0 1 0 0 1 1 1 0 Paf1 CAF-1_p150 PF11600.3 EFE45051.1 - 0.026 13.9 29.6 0.028 13.8 20.5 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CobT PF06213.7 EFE45051.1 - 0.033 13.3 10.6 0.036 13.1 7.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.7 EFE45051.1 - 0.035 12.0 11.4 0.034 12.1 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 EFE45051.1 - 0.043 12.3 13.8 0.042 12.3 9.6 1.1 1 0 0 1 1 1 0 Daxx Family RNA_pol_3_Rpc31 PF11705.3 EFE45051.1 - 0.078 12.9 13.5 0.088 12.7 9.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2457 PF10446.4 EFE45051.1 - 0.092 11.4 14.6 0.11 11.2 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) U79_P34 PF03064.11 EFE45051.1 - 0.1 12.1 12.6 0.11 11.9 8.8 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Vfa1 PF08432.5 EFE45051.1 - 0.1 12.5 15.6 0.16 11.9 10.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NARP1 PF12569.3 EFE45051.1 - 0.18 10.4 17.3 0.2 10.3 12.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Spore_coat_CotO PF14153.1 EFE45051.1 - 0.23 10.8 15.9 0.26 10.6 11.0 1.1 1 0 0 1 1 1 0 Spore coat protein CotO FLO_LFY PF01698.11 EFE45051.1 - 0.27 10.0 10.4 0.3 9.9 7.2 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Pap_E4 PF02711.9 EFE45051.1 - 0.34 11.7 5.9 0.48 11.2 4.1 1.2 1 0 0 1 1 1 0 E4 protein DUF1682 PF07946.9 EFE45051.1 - 0.38 9.5 17.4 0.48 9.2 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) BTV_NS2 PF04514.7 EFE45051.1 - 0.44 9.3 10.2 0.46 9.3 7.1 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF2413 PF10310.4 EFE45051.1 - 0.59 8.8 16.4 0.69 8.6 11.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) XRN_N PF03159.13 EFE45051.1 - 0.71 9.2 7.3 0.87 8.9 5.1 1.1 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus DUF1168 PF06658.7 EFE45051.1 - 0.9 9.0 27.0 1.5 8.3 18.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Zip PF02535.17 EFE45051.1 - 0.94 8.4 4.9 0.94 8.4 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GAGA_bind PF06217.7 EFE45051.1 - 1.2 9.0 7.5 1.2 9.0 5.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Cas_Csy4 PF09618.5 EFE45051.1 - 1.3 8.8 3.7 1.4 8.6 2.6 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) Rtf2 PF04641.7 EFE45051.1 - 1.4 8.1 15.1 2.1 7.4 10.5 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Neur_chan_memb PF02932.11 EFE45051.1 - 1.5 8.6 4.1 1.6 8.5 2.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Adeno_terminal PF02459.10 EFE45051.1 - 1.5 6.8 8.2 1.5 6.8 5.7 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Raftlin PF15250.1 EFE45051.1 - 1.6 7.1 5.7 1.5 7.2 3.9 1.1 1 0 0 1 1 1 0 Raftlin Gag_spuma PF03276.9 EFE45051.1 - 1.6 6.9 5.6 1.5 7.0 3.9 1.1 1 0 0 1 1 1 0 Spumavirus gag protein DDHD PF02862.12 EFE45051.1 - 1.7 8.3 8.2 1.9 8.2 5.7 1.1 1 0 0 1 1 1 0 DDHD domain PI3K_1B_p101 PF10486.4 EFE45051.1 - 2.3 5.7 8.2 2.7 5.4 5.7 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pilt PF15453.1 EFE45051.1 - 2.9 7.4 11.7 3.1 7.4 8.1 1.0 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions APG6 PF04111.7 EFE45051.1 - 4.9 6.1 9.4 5.3 5.9 6.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 PPP4R2 PF09184.6 EFE45051.1 - 5.5 6.4 17.2 7.5 6.0 11.9 1.1 1 0 0 1 1 1 0 PPP4R2 RR_TM4-6 PF06459.7 EFE45051.1 - 5.7 6.7 17.6 6.3 6.5 12.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NAM-associated PF14303.1 EFE45051.1 - 6.2 7.1 22.1 8.4 6.6 15.3 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain SAPS PF04499.10 EFE45051.1 - 7.8 5.0 8.7 9.7 4.6 6.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.9 EFE45051.1 - 8 4.3 15.3 10 4.0 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.11 EFE45051.1 - 8.1 5.3 10.9 10 5.0 7.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PAT1 PF09770.4 EFE45052.1 - 0.00065 18.0 30.1 0.00065 18.0 20.9 2.1 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 Sec1 PF00995.18 EFE45054.1 - 7.2e-152 506.9 0.0 8.3e-152 506.7 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Ribosomal_L28e PF01778.12 EFE45055.1 - 2e-34 118.4 0.1 2.8e-34 118.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family RRM_1 PF00076.17 EFE45056.1 - 1.1e-34 117.8 0.0 2.3e-16 59.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE45056.1 - 9.8e-18 63.9 0.0 1.1e-07 31.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE45056.1 - 7.7e-15 54.4 0.0 5.4e-07 29.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EFE45056.1 - 0.0068 16.1 0.3 0.51 10.1 0.1 2.2 2 0 0 2 2 2 1 Limkain b1 Cas_Cas2CT1978 PF09707.5 EFE45056.1 - 0.066 13.1 0.0 4.6 7.2 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) OB_RNB PF08206.6 EFE45056.1 - 0.15 11.5 0.1 9.5 5.8 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain Mito_carr PF00153.22 EFE45057.1 - 2.1e-69 229.2 3.3 2.6e-22 78.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-H2C2_2 PF13465.1 EFE45058.1 - 7.5e-15 54.3 18.8 1.3e-06 28.4 1.3 4.9 4 1 1 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.21 EFE45058.1 - 8.7e-15 54.0 16.7 3.9e-05 23.7 0.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFE45058.1 - 7.5e-12 44.7 13.3 0.0012 19.0 0.6 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.2 EFE45058.1 - 2.4e-05 24.3 4.7 0.25 11.5 0.1 3.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.5 EFE45058.1 - 0.31 11.0 5.3 13 5.8 0.1 3.4 3 0 0 3 3 3 0 Zinc ribbon domain Ogr_Delta PF04606.7 EFE45058.1 - 0.34 10.5 5.3 2 8.1 0.1 3.4 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger zf-LYAR PF08790.6 EFE45058.1 - 0.84 9.4 7.2 19 5.0 0.2 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-CHY PF05495.7 EFE45058.1 - 1.9 8.6 6.9 0.41 10.8 1.9 2.0 2 0 0 2 2 2 0 CHY zinc finger zf-C2H2_6 PF13912.1 EFE45058.1 - 2.7 8.0 9.4 1.6 8.7 0.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFE45058.1 - 8.8 6.6 7.7 5.7 7.2 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF2333 PF10095.4 EFE45059.1 - 0.11 11.0 0.1 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) Ldh_1_C PF02866.13 EFE45060.1 - 1.1e-39 135.8 0.0 1.5e-39 135.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 EFE45060.1 - 1.9e-27 95.8 1.2 6.7e-19 68.1 0.0 2.6 2 1 0 2 2 2 2 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.11 EFE45060.1 - 0.054 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase TRAPP PF04051.11 EFE45061.1 - 6.7e-05 22.4 0.0 7.9e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DOR PF14839.1 EFE45061.1 - 0.042 13.6 0.0 0.054 13.2 0.0 1.1 1 0 0 1 1 1 0 DOR family Glyco_transf_90 PF05686.7 EFE45062.1 - 3.6e-18 65.4 6.9 1.3e-13 50.4 3.0 3.7 2 1 0 2 2 2 2 Glycosyl transferase family 90 PINIT PF14324.1 EFE45063.1 - 2.3e-28 99.0 0.0 3.1e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 PINIT domain XPC-binding PF09280.6 EFE45064.1 - 3.3e-23 80.9 15.3 3.3e-23 80.9 10.6 1.8 2 0 0 2 2 2 1 XPC-binding domain ubiquitin PF00240.18 EFE45064.1 - 4e-22 77.3 0.2 6.3e-22 76.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.26 EFE45064.1 - 1.7e-17 62.6 0.6 1.4e-08 34.3 0.1 2.6 2 0 0 2 2 2 2 UBA/TS-N domain Rad60-SLD PF11976.3 EFE45064.1 - 1.1e-09 37.8 0.3 2e-09 36.9 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.5 EFE45064.1 - 0.0063 16.0 0.0 1.9 8.1 0.0 2.5 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain MCM_N PF14551.1 EFE45064.1 - 0.011 16.2 0.0 0.022 15.2 0.0 1.5 1 0 0 1 1 1 0 MCM N-terminal domain Rad60-SLD_2 PF13881.1 EFE45064.1 - 0.021 14.7 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rap1_C PF11626.3 EFE45064.1 - 0.045 13.6 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF2407 PF10302.4 EFE45064.1 - 0.11 12.7 0.0 0.3 11.2 0.0 1.8 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.1 EFE45064.1 - 0.12 12.6 0.1 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-like domain MSA-2c PF12238.3 EFE45064.1 - 3.8 7.1 11.7 1.2 8.8 3.9 2.4 2 0 0 2 2 2 0 Merozoite surface antigen 2c Pheromone PF08015.6 EFE45064.1 - 6.4 7.6 10.0 5.5 7.8 3.0 2.8 2 0 0 2 2 2 0 Fungal mating-type pheromone DUF3431 PF11913.3 EFE45065.1 - 3.5e-71 239.2 2.8 3.5e-71 239.2 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3431) Aminotran_1_2 PF00155.16 EFE45067.1 - 1.7e-31 109.4 0.0 1.1e-30 106.8 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFE45067.1 - 5.4e-09 35.2 0.0 7.4e-09 34.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EFE45067.1 - 9.5e-05 20.8 0.0 0.00012 20.5 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 EFE45067.1 - 9.7e-05 21.6 0.0 0.00013 21.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EFE45067.1 - 0.035 13.1 0.0 0.06 12.3 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.6 EFE45067.1 - 0.04 12.2 0.0 0.056 11.7 0.0 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase PHO4 PF01384.15 EFE45068.1 - 5.5e-121 403.1 15.9 6.4e-121 402.9 11.0 1.0 1 0 0 1 1 1 1 Phosphate transporter family Pkinase_Tyr PF07714.12 EFE45069.1 - 7.4e-13 48.1 0.0 1e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 EFE45069.1 - 3e-10 39.7 0.0 6.4e-10 38.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFE45069.1 - 0.009 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFE45069.1 - 0.044 13.3 0.0 0.067 12.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF3767 PF12597.3 EFE45069.1 - 0.048 13.3 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) TauD PF02668.11 EFE45070.1 - 7.4e-44 150.3 0.0 9e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family COesterase PF00135.23 EFE45071.1 - 0.11 11.2 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family SRR1 PF07985.7 EFE45072.1 - 2.8e-05 23.9 0.0 7.1e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 SRR1 eIF-6 PF01912.13 EFE45073.1 - 1.2e-79 265.9 0.9 1.7e-79 265.5 0.6 1.1 1 0 0 1 1 1 1 eIF-6 family dUTPase PF00692.14 EFE45074.1 - 1e-08 34.6 0.0 1.7e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 dUTPase RXT2_N PF08595.6 EFE45074.1 - 0.0093 15.7 0.2 0.011 15.4 0.1 1.2 1 0 0 1 1 1 1 RXT2-like, N-terminal PBP1_TM PF14812.1 EFE45074.1 - 0.015 15.5 9.4 0.023 14.9 6.5 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.7 EFE45074.1 - 0.05 13.2 6.6 0.063 12.9 4.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.1 EFE45074.1 - 0.061 13.0 1.2 0.085 12.5 0.8 1.2 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.5 EFE45074.1 - 0.082 13.1 5.7 0.12 12.5 4.0 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 EFE45074.1 - 0.21 11.2 2.2 0.27 10.8 1.5 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Myc_N PF01056.13 EFE45074.1 - 0.21 10.7 4.1 0.29 10.2 2.8 1.1 1 0 0 1 1 1 0 Myc amino-terminal region LAT PF15234.1 EFE45074.1 - 0.36 10.2 3.9 0.5 9.8 2.7 1.1 1 0 0 1 1 1 0 Linker for activation of T-cells Nucleoplasmin PF03066.10 EFE45074.1 - 0.39 10.2 5.0 0.56 9.7 3.5 1.2 1 0 0 1 1 1 0 Nucleoplasmin tRNA-synt_His PF13393.1 EFE45075.1 - 2.9e-38 131.6 0.0 3.6e-32 111.6 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 EFE45075.1 - 5e-18 65.2 0.0 1.2e-17 64.0 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFE45075.1 - 2.3e-13 49.9 0.0 4.2e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 EFE45075.1 - 0.0054 15.5 0.1 0.18 10.5 0.0 2.6 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) FAD_binding_3 PF01494.14 EFE45076.1 - 2.1e-22 79.7 0.0 4.3e-20 72.0 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFE45076.1 - 0.00053 18.9 0.0 0.017 14.0 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFE45076.1 - 0.0012 17.8 0.0 0.006 15.5 0.0 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 EFE45076.1 - 0.0057 16.4 0.0 0.0097 15.6 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding SE PF08491.5 EFE45076.1 - 0.016 14.0 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase Pyr_redox_2 PF07992.9 EFE45076.1 - 0.03 14.2 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFE45076.1 - 0.061 12.2 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 EFE45076.1 - 0.065 13.2 0.0 0.25 11.3 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFE45076.1 - 0.081 12.9 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain PX PF00787.19 EFE45077.1 - 1.3e-18 66.8 0.4 3.2e-18 65.5 0.3 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 EFE45077.1 - 2.9e-13 49.6 4.1 6.6e-06 25.5 0.1 2.1 2 0 0 2 2 2 2 Vps5 C terminal like TMF_DNA_bd PF12329.3 EFE45077.1 - 0.099 12.4 5.3 10 6.0 0.3 3.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.7 EFE45077.1 - 0.13 12.0 2.0 3.4 7.4 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BAR PF03114.13 EFE45077.1 - 1.1 8.7 6.3 8.5 5.8 4.4 2.1 1 1 0 1 1 1 0 BAR domain V_ATPase_I PF01496.14 EFE45077.1 - 9.8 3.8 6.1 35 2.0 4.2 1.7 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Metallophos PF00149.23 EFE45078.1 - 6.5e-08 32.2 1.3 0.0037 16.6 0.0 2.8 3 0 0 3 3 3 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFE45078.1 - 1e-05 25.4 0.0 2e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ABC_membrane PF00664.18 EFE45080.1 - 8.4e-77 258.2 30.4 1.1e-39 136.5 7.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE45080.1 - 3.1e-60 202.4 0.0 4.1e-29 101.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE45080.1 - 2.6e-15 56.2 6.8 1.1e-05 24.8 0.4 4.4 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EFE45080.1 - 4.7e-10 40.3 0.2 0.00091 20.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFE45080.1 - 1.1e-09 37.7 1.2 0.00058 19.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 EFE45080.1 - 2.8e-09 37.2 0.2 0.0012 19.0 0.0 3.7 2 2 0 2 2 2 2 AAA domain AAA_21 PF13304.1 EFE45080.1 - 7e-09 36.0 4.8 0.03 14.2 0.2 4.4 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.1 EFE45080.1 - 8.4e-07 29.1 0.3 0.0061 16.5 0.1 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.1 EFE45080.1 - 1.3e-06 28.7 0.2 0.11 12.8 0.1 3.1 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.1 EFE45080.1 - 1.4e-06 27.8 0.1 0.016 14.5 0.0 3.1 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 EFE45080.1 - 2.1e-06 26.9 0.2 0.088 11.9 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 EFE45080.1 - 1.3e-05 25.6 0.9 0.0036 17.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EFE45080.1 - 1.6e-05 24.4 4.2 0.2 11.0 0.1 3.9 4 0 0 4 4 4 2 AAA-like domain ABC_ATPase PF09818.4 EFE45080.1 - 0.0001 21.0 1.5 0.089 11.3 0.6 3.3 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA_33 PF13671.1 EFE45080.1 - 0.0005 19.9 0.0 0.68 9.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.13 EFE45080.1 - 0.0018 17.7 0.0 1.4 8.3 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family SbcCD_C PF13558.1 EFE45080.1 - 0.0025 17.6 0.1 1 9.3 0.0 3.3 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF3987 PF13148.1 EFE45080.1 - 0.0026 16.4 0.2 1.7 7.1 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) KaiC PF06745.8 EFE45080.1 - 0.006 15.7 0.2 2.9 6.9 0.0 2.7 2 0 0 2 2 2 1 KaiC MobB PF03205.9 EFE45080.1 - 0.0067 16.1 0.6 2.8 7.6 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.9 EFE45080.1 - 0.007 16.1 0.0 0.8 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF87 PF01935.12 EFE45080.1 - 0.0088 15.8 2.1 0.6 9.8 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function DUF87 APS_kinase PF01583.15 EFE45080.1 - 0.011 15.3 0.1 5 6.7 0.0 2.8 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA PF00004.24 EFE45080.1 - 0.013 15.6 0.0 0.87 9.7 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 EFE45080.1 - 0.016 15.3 0.0 11 6.2 0.0 2.8 3 0 0 3 3 2 0 RNA helicase IstB_IS21 PF01695.12 EFE45080.1 - 0.023 14.1 1.7 3.9 6.8 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_19 PF13245.1 EFE45080.1 - 0.025 14.3 4.1 0.44 10.3 0.2 3.9 4 0 0 4 4 3 0 Part of AAA domain AAA_14 PF13173.1 EFE45080.1 - 0.038 13.8 0.4 12 5.8 0.0 3.8 4 0 0 4 4 3 0 AAA domain NACHT PF05729.7 EFE45080.1 - 0.04 13.5 0.2 22 4.6 0.0 3.3 3 0 0 3 3 3 0 NACHT domain MMR_HSR1 PF01926.18 EFE45080.1 - 0.075 12.9 3.3 3.5 7.5 0.1 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase Guanylate_kin PF00625.16 EFE45080.1 - 0.086 12.2 0.1 4 6.8 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase AAA_30 PF13604.1 EFE45080.1 - 0.11 12.0 0.0 7.5 6.0 0.0 2.9 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 EFE45080.1 - 0.15 11.2 0.1 2 7.5 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 EFE45080.1 - 0.22 10.5 0.4 21 4.1 0.1 2.8 3 0 0 3 3 3 0 Zeta toxin CbiA PF01656.18 EFE45080.1 - 2.9 7.2 4.8 27 4.1 0.1 3.1 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain MFS_1 PF07690.11 EFE45081.1 - 1.3e-30 106.3 45.0 1.3e-30 106.3 31.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily p450 PF00067.17 EFE45082.1 - 8.4e-44 149.8 0.2 1e-43 149.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ric8 PF10165.4 EFE45083.1 - 2.3e-126 422.2 0.0 3.1e-126 421.7 0.0 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Polysacc_synt_4 PF04669.8 EFE45084.1 - 1.1e-16 60.7 0.8 6.5e-16 58.2 0.5 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis Sugar_tr PF00083.19 EFE45085.1 - 2.6e-133 444.9 18.8 9.7e-96 321.0 8.2 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE45085.1 - 3.4e-22 78.6 27.8 3e-18 65.6 9.0 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_A14 PF05767.7 EFE45085.1 - 0.21 11.5 0.0 0.21 11.5 0.0 2.6 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 Glyco_hydro_25 PF01183.15 EFE45086.1 - 2e-39 135.2 0.1 2.4e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 PsbR PF04725.7 EFE45086.1 - 0.041 13.9 0.3 0.11 12.5 0.2 1.8 1 1 0 1 1 1 0 Photosystem II 10 kDa polypeptide PsbR Rif1_N PF12231.3 EFE45087.1 - 7.9e-129 429.8 0.7 1.1e-128 429.3 0.1 1.6 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal Aldose_epim PF01263.15 EFE45089.1 - 8.3e-36 123.6 0.0 9.9e-36 123.3 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase MFS_1 PF07690.11 EFE45090.1 - 7.9e-25 87.3 26.0 7.9e-25 87.3 18.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DAHP_synth_2 PF01474.11 EFE45092.1 - 6.4e-138 459.7 0.0 7.2e-138 459.6 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family PLA2_B PF01735.13 EFE45094.1 - 1.4e-188 627.1 0.5 1.6e-188 626.8 0.4 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain adh_short PF00106.20 EFE45096.1 - 3e-30 105.3 1.1 3.8e-30 104.9 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE45096.1 - 1e-29 104.0 0.0 1.2e-29 103.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE45096.1 - 4.9e-18 65.4 0.4 7.1e-18 64.8 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFE45096.1 - 0.0047 16.3 0.1 0.0068 15.8 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1537 PF07005.6 EFE45096.1 - 0.013 15.1 0.6 1.5 8.4 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function, DUF1537 3H PF02829.9 EFE45096.1 - 0.096 12.7 0.1 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 3H domain Ribosomal_L18p PF00861.17 EFE45096.1 - 0.17 12.0 1.7 1.5 9.0 0.0 2.8 1 1 3 4 4 4 0 Ribosomal L18p/L5e family AIG2 PF06094.7 EFE45097.1 - 7.2e-11 42.4 0.2 9.7e-11 42.0 0.1 1.2 1 0 0 1 1 1 1 AIG2-like family Piwi PF02171.12 EFE45098.1 - 1.2e-71 241.2 0.0 1.8e-71 240.6 0.0 1.3 1 0 0 1 1 1 1 Piwi domain DUF1785 PF08699.5 EFE45098.1 - 2e-12 46.2 0.1 4.4e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) PAZ PF02170.17 EFE45098.1 - 5e-09 35.5 0.0 1.2e-08 34.3 0.0 1.6 1 1 0 1 1 1 1 PAZ domain DUF663 PF04950.7 EFE45098.1 - 0.12 11.2 0.2 0.18 10.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF663) TFIIA PF03153.8 EFE45099.1 - 0.86 9.4 3.7 0.92 9.3 2.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF566 PF04484.7 EFE45099.1 - 7.7 5.9 9.5 10 5.5 6.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) Ribophorin_II PF05817.9 EFE45100.1 - 5.6e-18 64.5 0.1 8.1e-18 63.9 0.1 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF4622 PF15415.1 EFE45100.1 - 0.0053 15.5 0.0 0.0082 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4622) PufQ PF05398.6 EFE45100.1 - 0.33 11.0 1.4 2.3 8.3 0.0 2.4 3 0 0 3 3 3 0 PufQ cytochrome subunit DUF1049 PF06305.6 EFE45100.1 - 0.84 9.1 5.3 2.7 7.5 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1049) DUF566 PF04484.7 EFE45101.1 - 2 7.8 5.7 2.5 7.5 3.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) EVE PF01878.13 EFE45102.1 - 2.9e-46 157.0 0.1 2.9e-46 157.0 0.0 1.9 2 0 0 2 2 2 1 EVE domain Glycolipid_bind PF06475.6 EFE45102.1 - 0.089 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative glycolipid-binding Methyltransf_PK PF05891.7 EFE45103.1 - 6.4e-66 221.7 0.0 1e-65 221.0 0.0 1.3 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.13 EFE45103.1 - 2.2e-07 30.3 0.0 3e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 EFE45103.1 - 0.00013 21.7 0.0 0.00018 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFE45103.1 - 0.00068 20.2 0.1 0.002 18.6 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFE45103.1 - 0.0093 16.4 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE45103.1 - 0.11 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.13 EFE45103.1 - 0.14 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Aldedh PF00171.17 EFE45104.1 - 9.1e-182 604.4 3.4 1e-181 604.3 2.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 EFE45104.1 - 0.0018 17.5 0.0 0.0074 15.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) UQ_con PF00179.21 EFE45108.1 - 0.0039 16.6 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Bac_surface_Ag PF01103.18 EFE45109.1 - 2.7e-39 135.5 0.0 3.9e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Surface antigen TSKS PF15358.1 EFE45109.1 - 0.14 10.2 0.3 0.21 9.7 0.2 1.1 1 0 0 1 1 1 0 Testis-specific serine kinase substrate Yip1 PF04893.12 EFE45110.1 - 5.9e-07 29.1 11.9 9.1e-05 22.0 5.6 2.4 2 0 0 2 2 2 2 Yip1 domain TFIIA PF03153.8 EFE45111.1 - 2.3 8.0 27.8 2.8 7.7 19.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.4 EFE45111.1 - 2.9 6.0 22.0 3.1 5.9 15.3 1.0 1 0 0 1 1 1 0 Transmembrane protein UFD1 PF03152.9 EFE45113.1 - 1.2e-26 92.9 0.0 3e-24 85.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 HD_2 PF12917.2 EFE45113.1 - 0.12 12.1 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme DPPIV_N PF00930.16 EFE45114.1 - 8.1e-110 366.7 6.1 1.4e-109 365.9 4.2 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 EFE45114.1 - 2.3e-29 102.1 1.5 1.7e-24 86.2 0.1 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFE45114.1 - 0.0012 18.7 0.0 0.0027 17.5 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFE45114.1 - 0.0013 18.4 0.0 0.0033 17.1 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S8 PF00082.17 EFE45115.1 - 2.3e-38 131.9 12.5 3.4e-38 131.4 8.6 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFE45115.1 - 9.6e-14 51.7 0.1 1.9e-13 50.7 0.1 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 MAPEG PF01124.13 EFE45116.1 - 1.5e-09 37.5 3.6 2e-09 37.1 2.4 1.4 1 1 0 1 1 1 1 MAPEG family MARVEL PF01284.18 EFE45117.1 - 7.9e-08 32.2 4.6 9.3e-08 32.0 3.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain ABC2_membrane_5 PF13346.1 EFE45117.1 - 0.43 9.8 8.8 0.62 9.3 6.1 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF1129 PF06570.6 EFE45117.1 - 1.5 8.0 4.1 2.2 7.5 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) CytB6-F_Fe-S PF08802.5 EFE45117.1 - 2.4 8.2 7.3 0.19 11.7 1.1 2.1 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit RNB PF00773.14 EFE45118.1 - 3.5e-57 194.1 0.0 7.7e-56 189.7 0.0 2.2 1 1 0 1 1 1 1 RNB domain DUF3148 PF11347.3 EFE45118.1 - 0.077 12.6 0.0 1 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3148) CTNNBL PF08216.6 EFE45119.1 - 1.6e-18 66.2 0.9 9.5e-18 63.7 0.0 2.6 3 0 0 3 3 3 1 Catenin-beta-like, Arm-motif containing nuclear Drf_GBD PF06371.8 EFE45119.1 - 0.0091 15.3 0.9 0.33 10.2 0.0 3.5 4 1 0 4 4 4 1 Diaphanous GTPase-binding Domain DUF4363 PF14276.1 EFE45119.1 - 0.085 12.5 0.7 1 9.0 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) RNA_pol_Rpb2_6 PF00562.23 EFE45120.1 - 1.4e-123 412.4 0.2 3.4e-123 411.2 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EFE45120.1 - 1.3e-60 203.8 0.0 2e-60 203.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 EFE45120.1 - 2.4e-47 160.8 0.0 4.1e-47 160.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.8 EFE45120.1 - 2.9e-24 84.6 0.4 6.6e-24 83.4 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.12 EFE45120.1 - 6.5e-24 83.6 0.3 1.8e-23 82.2 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_3 PF04565.11 EFE45120.1 - 1.2e-22 79.3 1.1 1.7e-22 78.9 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.15 EFE45120.1 - 2.4e-18 66.1 0.0 5.3e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 DUF2306 PF10067.4 EFE45122.1 - 3.2e-12 46.4 3.3 3.2e-12 46.4 2.3 2.2 2 1 0 2 2 2 1 Predicted membrane protein (DUF2306) DUF420 PF04238.7 EFE45122.1 - 0.0041 17.0 0.2 0.0041 17.0 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF420) RDD PF06271.7 EFE45122.1 - 1.6 8.6 11.8 0.18 11.6 3.0 2.4 1 1 1 2 2 2 0 RDD family Sugar_tr PF00083.19 EFE45123.1 - 2e-63 214.5 25.2 3e-50 171.1 9.3 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFE45123.1 - 1.6e-23 82.9 34.6 3.1e-11 42.5 8.3 3.1 1 1 1 3 3 3 3 Major Facilitator Superfamily DUF1761 PF08570.5 EFE45123.1 - 3.8 7.5 19.8 0.042 13.8 3.0 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1761) Zn_clus PF00172.13 EFE45124.1 - 0.0098 15.7 0.6 0.028 14.3 0.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_membrane PF00664.18 EFE45125.1 - 3.6e-88 295.5 39.5 6.9e-47 160.1 8.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFE45125.1 - 7.4e-67 223.8 0.0 8.6e-33 113.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFE45125.1 - 4.5e-14 52.2 0.0 6.5e-05 22.2 0.0 3.4 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFE45125.1 - 7.2e-12 45.8 3.2 0.0052 16.7 0.1 4.3 2 2 1 3 3 3 3 AAA domain AAA_29 PF13555.1 EFE45125.1 - 7.8e-08 31.7 0.8 0.00051 19.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 EFE45125.1 - 1.8e-07 30.1 1.2 0.012 14.1 0.0 2.8 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_17 PF13207.1 EFE45125.1 - 5.8e-07 30.3 0.0 0.041 14.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFE45125.1 - 3.4e-06 26.3 0.0 0.14 11.3 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 EFE45125.1 - 6.6e-06 26.2 1.5 0.032 14.2 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 EFE45125.1 - 2e-05 24.0 0.1 0.24 10.7 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA_22 PF13401.1 EFE45125.1 - 0.00028 21.0 2.4 1.1 9.4 0.1 3.8 2 2 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 EFE45125.1 - 0.00067 19.5 2.7 0.64 9.9 0.3 3.5 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.1 EFE45125.1 - 0.0017 18.6 0.0 3.6 7.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 EFE45125.1 - 0.0018 18.1 0.1 2 8.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 EFE45125.1 - 0.0022 17.8 0.0 8.2 6.3 0.0 3.9 4 0 0 4 4 4 0 AAA domain AAA_10 PF12846.2 EFE45125.1 - 0.0049 16.3 3.0 4 6.7 0.2 4.1 4 0 0 4 4 4 1 AAA-like domain AAA_23 PF13476.1 EFE45125.1 - 0.0058 16.9 0.0 0.63 10.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.15 EFE45125.1 - 0.0061 15.2 0.2 2.9 6.4 0.0 2.6 3 0 0 3 3 3 2 G-protein alpha subunit AAA_28 PF13521.1 EFE45125.1 - 0.0075 16.2 0.4 1 9.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 EFE45125.1 - 0.008 15.2 0.0 2.2 7.2 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EFE45125.1 - 0.0097 15.6 0.0 3.5 7.3 0.0 3.5 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) DUF87 PF01935.12 EFE45125.1 - 0.036 13.8 0.8 0.59 9.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 RNA_helicase PF00910.17 EFE45125.1 - 0.083 13.0 0.4 7 6.8 0.0 3.1 3 0 0 3 3 2 0 RNA helicase MobB PF03205.9 EFE45125.1 - 0.12 12.0 1.0 15 5.2 0.0 3.2 4 0 0 4 4 2 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 EFE45125.1 - 0.15 11.9 0.2 12 5.8 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Transferase PF02458.10 EFE45126.1 - 1.5e-13 49.9 0.0 2e-11 42.9 0.0 2.8 2 1 0 2 2 2 2 Transferase family FSH1 PF03959.8 EFE45127.1 - 6.7e-21 74.7 0.1 2.4e-12 46.7 0.0 3.4 1 1 2 3 3 3 3 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 EFE45127.1 - 5.4e-07 29.7 0.0 7.7e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFE45127.1 - 0.0038 16.7 0.1 0.53 9.6 0.1 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase DSPc PF00782.15 EFE45127.1 - 0.097 12.2 0.0 0.65 9.5 0.0 2.1 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain p450 PF00067.17 EFE45128.1 - 2.7e-29 101.9 0.0 3.3e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.7 EFE45129.1 - 3.3e-18 65.4 2.0 6.6e-18 64.4 1.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFE45129.1 - 2.8e-13 49.5 0.1 4.9e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EFE45129.1 - 0.00029 20.0 0.1 0.00045 19.4 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.16 EFE45129.1 - 0.0014 18.2 0.1 0.0022 17.6 0.1 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Mito_carr PF00153.22 EFE45130.1 - 1.2e-42 143.4 9.5 7.5e-17 60.8 0.3 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein NAD_binding_6 PF08030.7 EFE45131.1 - 6.6e-14 52.0 0.0 8.6e-14 51.7 0.0 1.1 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EFE45131.1 - 0.0061 17.1 0.0 1.3 9.5 0.0 2.2 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain Host_attach PF10116.4 EFE45131.1 - 0.0099 16.1 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein required for attachment to host cells FAD_binding_8 PF08022.7 EFE45131.1 - 0.011 15.6 0.0 0.025 14.4 0.0 1.6 2 0 0 2 2 2 0 FAD-binding domain ABC1 PF03109.11 EFE45132.1 - 9.9e-22 77.1 0.2 2.8e-21 75.6 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 EFE45132.1 - 0.0045 16.7 0.5 0.037 13.7 0.1 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family IMS PF00817.15 EFE45133.1 - 1.9e-36 125.1 0.0 2.6e-35 121.4 0.0 2.2 1 1 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EFE45133.1 - 1.1e-12 47.9 0.0 1.8e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DAO PF01266.19 EFE45133.1 - 0.16 10.8 0.1 0.46 9.3 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase IMS_HHH PF11798.3 EFE45133.1 - 0.16 12.0 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif WSC PF01822.14 EFE45135.1 - 3.1e-09 36.6 10.0 3.1e-09 36.6 6.9 3.1 2 1 0 3 3 3 1 WSC domain FixQ PF05545.6 EFE45135.1 - 1.7e-05 24.3 0.1 4.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF966 PF06136.8 EFE45135.1 - 0.031 13.7 13.9 0.041 13.3 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Rifin_STEVOR PF02009.11 EFE45135.1 - 0.11 12.1 0.1 0.32 10.5 0.0 1.7 1 1 1 2 2 2 0 Rifin/stevor family TMEM154 PF15102.1 EFE45135.1 - 2.7 7.6 27.3 1.5e+04 -4.5 18.9 3.2 1 1 0 1 1 1 0 TMEM154 protein family Transp_cyt_pur PF02133.10 EFE45136.1 - 3e-25 88.6 32.7 3e-25 88.6 22.7 1.5 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin PRP38 PF03371.10 EFE45137.1 - 1.1e-66 223.7 0.0 1.3e-66 223.4 0.0 1.1 1 0 0 1 1 1 1 PRP38 family WD40 PF00400.27 EFE45139.1 - 2.6e-21 74.6 6.6 0.0015 18.2 0.0 7.2 8 0 0 8 8 8 5 WD domain, G-beta repeat Trypan_PARP PF05887.6 EFE45139.1 - 0.014 15.1 3.3 0.014 15.1 2.3 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) AAA_12 PF13087.1 EFE45140.1 - 7.2e-38 129.9 0.0 1.1e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EFE45140.1 - 1.1e-24 87.3 0.0 3.6e-24 85.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFE45140.1 - 3.3e-10 39.5 0.0 7.4e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EFE45140.1 - 9.6e-10 38.3 0.0 1.2e-07 31.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 EFE45140.1 - 3.2e-07 30.1 0.1 0.00028 20.5 0.0 3.3 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.10 EFE45140.1 - 0.00078 19.3 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.11 EFE45140.1 - 0.0011 18.2 0.0 0.0026 17.0 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.4 EFE45140.1 - 0.0042 16.1 0.2 0.15 11.0 0.0 2.6 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.24 EFE45140.1 - 0.0085 15.5 0.0 0.019 14.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD_C_2 PF13538.1 EFE45140.1 - 0.064 13.3 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 EFE45140.1 - 0.12 11.6 0.1 0.34 10.1 0.0 1.7 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain ABC_tran PF00005.22 EFE45142.1 - 2.1e-56 190.0 0.2 7.2e-31 107.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFE45142.1 - 1.4e-43 149.2 25.7 4.2e-25 88.6 8.0 3.4 3 0 0 3 3 3 3 ABC transporter transmembrane region AAA_21 PF13304.1 EFE45142.1 - 1e-08 35.5 3.2 0.0052 16.7 0.0 4.2 4 1 0 4 4 4 2 AAA domain AAA_25 PF13481.1 EFE45142.1 - 1.5e-07 31.0 0.1 0.013 14.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 EFE45142.1 - 2.9e-07 29.9 9.2 0.0066 15.6 0.2 4.6 3 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFE45142.1 - 1.1e-06 29.1 4.9 0.00014 22.2 0.1 2.9 3 0 0 3 3 2 2 AAA domain AAA_10 PF12846.2 EFE45142.1 - 3.8e-06 26.5 0.4 0.43 9.9 0.0 3.4 3 0 0 3 3 3 2 AAA-like domain DUF258 PF03193.11 EFE45142.1 - 1.9e-05 23.8 0.1 0.21 10.7 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EFE45142.1 - 5.2e-05 23.1 0.1 0.098 12.6 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.1 EFE45142.1 - 5.3e-05 22.6 0.2 0.33 10.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.7 EFE45142.1 - 0.00029 19.9 0.7 0.11 11.5 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin T2SE PF00437.15 EFE45142.1 - 0.00037 19.5 0.1 0.015 14.2 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.1 EFE45142.1 - 0.00047 20.1 1.2 1.1 9.2 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.12 EFE45142.1 - 0.00054 19.8 1.2 0.021 14.6 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_17 PF13207.1 EFE45142.1 - 0.0011 19.7 0.1 3.3 8.5 0.0 3.1 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 EFE45142.1 - 0.0012 19.2 0.1 2.9 8.4 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein FtsK_SpoIIIE PF01580.13 EFE45142.1 - 0.002 17.6 0.0 0.62 9.5 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.1 EFE45142.1 - 0.0023 18.0 1.2 4.8 7.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 EFE45142.1 - 0.0042 17.3 1.7 2.6 8.3 0.0 3.3 3 0 0 3 3 2 1 AAA domain MobB PF03205.9 EFE45142.1 - 0.0059 16.3 0.2 8.3 6.1 0.0 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 EFE45142.1 - 0.0092 15.4 1.2 2.1 7.6 0.0 3.0 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA PF00004.24 EFE45142.1 - 0.013 15.6 0.3 2.4 8.3 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.20 EFE45142.1 - 0.042 13.3 0.3 4.1 6.8 0.0 2.8 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.18 EFE45142.1 - 0.075 12.8 1.7 3.9 7.2 0.0 3.0 3 0 0 3 3 3 0 Dynamin family TrwB_AAD_bind PF10412.4 EFE45142.1 - 0.12 11.0 0.8 4.8 5.6 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_33 PF13671.1 EFE45142.1 - 0.13 12.1 0.0 13 5.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 EFE45142.1 - 0.14 11.9 0.0 12 5.6 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit NACHT PF05729.7 EFE45142.1 - 0.44 10.1 3.1 3.5 7.2 0.2 2.5 2 0 0 2 2 2 0 NACHT domain UPF0079 PF02367.12 EFE45142.1 - 0.68 9.5 3.9 10 5.7 0.1 2.9 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 Peptidase_M36 PF02128.10 EFE45143.1 - 7.9e-160 531.7 0.5 1e-159 531.3 0.4 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.8 EFE45143.1 - 1.6e-12 46.6 4.5 2.6e-12 45.9 1.6 2.5 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.10 EFE45143.1 - 3.7e-06 26.7 0.0 9.3e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain Colicin_M PF14859.1 EFE45143.1 - 0.05 12.4 0.0 0.082 11.7 0.0 1.3 1 0 0 1 1 1 0 Colicin M Peptidase_MA_2 PF13485.1 EFE45143.1 - 0.079 13.0 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 Peptidase MA superfamily UQ_con PF00179.21 EFE45144.1 - 5e-40 136.1 0.0 6.3e-40 135.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFE45144.1 - 0.0048 16.6 0.0 0.02 14.6 0.0 1.8 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFE45144.1 - 0.01 15.7 0.2 0.022 14.6 0.1 1.8 1 1 0 1 1 1 0 RWD domain Bax1-I PF01027.15 EFE45145.1 - 5.3e-53 179.6 28.5 6.2e-53 179.4 19.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.2 EFE45145.1 - 0.00039 19.6 12.4 0.00062 19.0 8.6 1.4 1 1 0 1 1 1 1 Bax inhibitor 1 like Orbi_NS3 PF01616.11 EFE45145.1 - 0.16 10.9 2.4 0.61 9.0 0.3 2.1 2 0 0 2 2 2 0 Orbivirus NS3 Myc_target_1 PF15179.1 EFE45145.1 - 0.28 10.7 0.1 0.28 10.7 0.1 1.7 2 0 0 2 2 2 0 Myc target protein 1 7TMR-DISM_7TM PF07695.6 EFE45145.1 - 0.42 10.2 27.2 1.5 8.4 3.3 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling Lysis_S PF04971.7 EFE45145.1 - 1.2 8.8 5.4 0.36 10.5 1.3 2.0 2 0 0 2 2 2 0 Lysis protein S Aa_trans PF01490.13 EFE45146.1 - 9e-70 235.1 25.4 3.3e-39 134.5 1.9 3.2 2 1 1 3 3 3 3 Transmembrane amino acid transporter protein Glyco_hydro_75 PF07335.6 EFE45147.1 - 3.7e-42 143.8 0.1 4.5e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 DUF1620 PF07774.8 EFE45148.1 - 2e-70 236.4 0.0 5.7e-70 234.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 EFE45148.1 - 3.4e-15 56.1 7.7 6e-13 48.8 1.4 2.8 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.16 EFE45148.1 - 6.6e-06 25.4 4.0 1.1 8.8 0.0 5.7 5 0 0 5 5 5 2 PQQ enzyme repeat AT_hook PF02178.14 EFE45149.1 - 2.6e-07 29.5 66.8 0.019 14.5 1.3 6.7 6 0 0 6 6 6 6 AT hook motif DENN PF02141.16 EFE45150.1 - 6.5e-55 185.7 0.1 1.2e-54 184.8 0.1 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.14 EFE45150.1 - 7.7e-20 70.7 0.3 1.6e-19 69.6 0.2 1.6 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.13 EFE45150.1 - 1.4e-18 66.5 0.0 3.8e-18 65.2 0.0 1.8 1 0 0 1 1 1 1 uDENN domain C1_1 PF00130.17 EFE45150.1 - 0.002 17.7 4.7 0.0041 16.8 3.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_3 PF07649.7 EFE45150.1 - 0.0089 16.0 4.8 0.0089 16.0 3.4 1.8 2 0 0 2 2 2 1 C1-like domain Vps39_2 PF10367.4 EFE45150.1 - 0.12 12.5 1.0 0.27 11.4 0.7 1.5 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 C1_2 PF03107.11 EFE45150.1 - 2.4 8.3 6.3 5 7.3 4.4 1.6 1 0 0 1 1 1 0 C1 domain PHD PF00628.24 EFE45150.1 - 2.7 7.7 8.6 2.3 7.9 4.5 2.0 1 1 1 2 2 2 0 PHD-finger Kri1 PF05178.7 EFE45151.1 - 2.8 8.2 9.0 2.9 8.2 6.2 1.0 1 0 0 1 1 1 0 KRI1-like family DUF974 PF06159.8 EFE45153.1 - 3.8e-53 180.4 0.0 4.5e-53 180.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) CENP-N PF05238.8 EFE45154.1 - 1.7e-116 389.5 0.2 2e-116 389.3 0.1 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like bZIP_2 PF07716.10 EFE45155.1 - 3.4e-12 45.9 11.9 3.4e-12 45.9 8.3 2.4 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.16 EFE45155.1 - 2.1e-06 27.5 11.1 2.1e-06 27.5 7.7 1.9 2 0 0 2 2 2 1 bZIP transcription factor V_ATPase_I PF01496.14 EFE45155.1 - 2.7 5.7 3.9 4 5.1 2.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BRO1 PF03097.13 EFE45156.1 - 7e-95 317.9 0.0 2.8e-83 279.7 0.0 3.4 2 1 1 3 3 3 2 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 EFE45156.1 - 1.9e-86 289.7 13.2 1.9e-86 289.7 9.2 2.0 3 0 0 3 3 3 1 ALIX V-shaped domain binding to HIV zf-C4H2 PF10146.4 EFE45156.1 - 0.6 10.0 7.6 0.1 12.6 1.0 2.7 1 1 2 3 3 3 0 Zinc finger-containing protein Mito_carr PF00153.22 EFE45157.1 - 5.4e-26 90.1 4.1 1e-15 57.2 0.3 3.6 3 1 0 3 3 3 2 Mitochondrial carrier protein Thiolase_C PF02803.13 EFE45159.1 - 8e-12 44.6 3.1 6.1e-11 41.8 0.0 2.7 2 1 1 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III PF08545.5 EFE45159.1 - 4e-08 32.7 0.1 3.7e-06 26.5 0.0 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.18 EFE45159.1 - 8.5e-06 24.9 0.3 1.9e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 EFE45159.1 - 0.0053 16.2 0.0 0.0099 15.3 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.6 EFE45159.1 - 0.01 14.3 0.4 0.034 12.6 0.1 1.9 2 0 0 2 2 2 1 Stage V sporulation protein AD (SpoVAD) DUF3208 PF11482.3 EFE45159.1 - 0.072 13.2 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3208) AIF-MLS PF14962.1 EFE45160.1 - 0.096 12.3 10.9 0.12 12.0 7.6 1.2 1 0 0 1 1 1 0 Mitochondria Localisation Sequence RRM_1 PF00076.17 EFE45161.1 - 2.6e-15 55.7 0.0 7e-15 54.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFE45161.1 - 3.4e-10 39.7 0.0 6.5e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFE45161.1 - 6.8e-07 29.0 0.1 1.2e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAM_LAG1_CLN8 PF03798.11 EFE45162.1 - 6.6e-38 130.2 22.3 6.6e-38 130.2 15.5 1.8 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.6 EFE45162.1 - 3.6e-14 51.9 0.1 3.6e-14 51.9 0.0 2.1 2 0 0 2 2 2 1 TRAM1-like protein Spt5_N PF11942.3 EFE45163.1 - 0.085 13.4 6.2 0.095 13.3 4.3 1.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal CENP-B_dimeris PF09026.5 EFE45163.1 - 0.13 12.5 3.2 0.13 12.5 2.2 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.1 EFE45163.1 - 0.38 10.4 2.2 0.37 10.4 1.5 1.0 1 0 0 1 1 1 0 FAM176 family Nucleoplasmin PF03066.10 EFE45163.1 - 0.4 10.1 7.3 0.38 10.2 5.0 1.1 1 0 0 1 1 1 0 Nucleoplasmin DUF2897 PF11446.3 EFE45163.1 - 0.54 10.1 3.1 0.7 9.7 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) S-antigen PF05756.6 EFE45163.1 - 0.7 9.9 5.3 0.73 9.8 3.6 1.0 1 0 0 1 1 1 0 S-antigen protein PBP1_TM PF14812.1 EFE45163.1 - 1.1 9.6 3.9 1.1 9.6 2.7 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BSP_II PF05432.6 EFE45163.1 - 1.1 8.4 8.5 1.2 8.3 5.9 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Myc_N PF01056.13 EFE45163.1 - 1.3 8.0 4.1 1.1 8.3 2.8 1.0 1 0 0 1 1 1 0 Myc amino-terminal region DUF2951 PF11166.3 EFE45163.1 - 3 7.7 5.6 3.4 7.5 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF3682 PF12446.3 EFE45163.1 - 4.5 7.5 7.0 4.8 7.4 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Radial_spoke PF04712.7 EFE45163.1 - 5.1 5.7 6.7 5.5 5.6 4.6 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein AA_permease_2 PF13520.1 EFE45164.1 - 2.4e-42 144.9 56.2 3e-42 144.6 38.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE45164.1 - 1.3e-22 79.8 50.1 1.4e-21 76.4 34.7 2.3 1 1 0 1 1 1 1 Amino acid permease CD20 PF04103.10 EFE45166.1 - 2.1 8.2 10.6 0.086 12.7 0.8 2.7 2 1 1 3 3 3 0 CD20-like family PPTA PF01239.17 EFE45168.1 - 0.00012 21.2 4.5 0.44 9.9 0.5 3.3 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat CR6_interact PF10147.4 EFE45169.1 - 0.83 8.9 6.6 0.75 9.0 4.6 1.0 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 YqzE PF14038.1 EFE45169.1 - 3.8 7.3 5.6 3.5 7.4 3.9 1.1 1 0 0 1 1 1 0 YqzE-like protein Velvet PF11754.3 EFE45170.1 - 1.3e-62 211.0 0.0 3e-62 209.8 0.0 1.6 1 0 0 1 1 1 1 Velvet factor DUF3899 PF13038.1 EFE45171.1 - 5.5 7.2 7.1 8.9 6.5 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) TBPIP PF07106.8 EFE45172.1 - 0.037 13.5 1.1 0.064 12.7 0.8 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) D-ser_dehydrat PF14031.1 EFE45173.1 - 4.3e-29 100.5 0.0 4.2e-28 97.3 0.0 2.2 2 0 0 2 2 2 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 EFE45173.1 - 4e-13 49.4 0.0 6e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ribonuc_L-PSP PF01042.16 EFE45174.1 - 3.3e-34 117.2 0.1 2.4e-28 98.3 0.0 2.1 2 0 0 2 2 2 2 Endoribonuclease L-PSP NESP55 PF06390.7 EFE45175.1 - 0.037 13.4 8.2 0.038 13.3 5.7 1.0 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Rrp15p PF07890.7 EFE45175.1 - 0.17 11.9 6.7 0.19 11.8 4.7 1.0 1 0 0 1 1 1 0 Rrp15p BRF1 PF07741.8 EFE45175.1 - 0.19 11.9 6.8 0.18 12.0 4.7 1.0 1 0 0 1 1 1 0 Brf1-like TBP-binding domain BLVR PF06375.6 EFE45175.1 - 0.27 11.0 7.1 0.28 11.0 4.9 1.0 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Med19 PF10278.4 EFE45175.1 - 0.44 10.2 11.7 0.47 10.1 8.1 1.0 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RNA_polI_A34 PF08208.6 EFE45175.1 - 0.61 9.7 11.4 0.65 9.6 7.9 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Peptidase_S49_N PF08496.5 EFE45175.1 - 1.2 8.9 6.2 1.2 8.9 4.3 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF809 PF05663.6 EFE45175.1 - 4.9 7.0 6.9 5 7.0 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF809) NARP1 PF12569.3 EFE45175.1 - 5.1 5.7 7.0 4.7 5.8 4.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DHDPS PF00701.17 EFE45176.1 - 2.9e-36 124.5 0.0 1.6e-35 122.1 0.0 1.8 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family MFS_1 PF07690.11 EFE45177.1 - 2.1e-30 105.6 24.3 3e-30 105.1 16.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PEP_mutase PF13714.1 EFE45178.1 - 2.4e-63 213.5 0.0 2.9e-63 213.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase MinE PF03776.9 EFE45178.1 - 0.056 12.9 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE Cyclase PF04199.8 EFE45179.1 - 2.5e-15 56.5 0.0 4.1e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Putative cyclase AA_permease_2 PF13520.1 EFE45181.1 - 4.4e-53 180.3 35.2 5.7e-53 179.9 24.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFE45181.1 - 6e-27 94.1 33.7 7.2e-27 93.8 23.4 1.0 1 0 0 1 1 1 1 Amino acid permease Orai-1 PF07856.7 EFE45181.1 - 5.7 6.4 11.2 0.16 11.5 0.3 2.9 3 0 0 3 3 3 0 Mediator of CRAC channel activity UQ_con PF00179.21 EFE45182.1 - 1.9e-11 43.5 0.0 1.6e-07 30.8 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme JmjC PF02373.17 EFE45183.1 - 9.7e-38 128.9 1.2 1.7e-37 128.1 0.3 1.8 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.1 EFE45183.1 - 8.2e-19 67.6 2.4 1.4e-18 66.8 1.7 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFE45183.1 - 1.4e-18 66.8 2.6 2.6e-18 65.9 1.8 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain JmjN PF02375.12 EFE45183.1 - 2.3e-14 52.5 0.4 5.7e-14 51.3 0.3 1.7 1 0 0 1 1 1 1 jmjN domain Carn_acyltransf PF00755.15 EFE45184.1 - 1.6e-159 531.7 0.0 8.4e-159 529.3 0.0 1.8 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase MFS_1_like PF12832.2 EFE45185.1 - 0.19 11.5 3.4 0.22 11.3 1.5 1.7 2 0 0 2 2 2 0 MFS_1 like family RhoGAP PF00620.22 EFE45186.1 - 5.2e-46 156.0 0.1 1.6e-45 154.4 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.17 EFE45186.1 - 3.8e-14 52.4 18.7 1.8e-09 37.5 2.0 2.4 2 0 0 2 2 2 2 LIM domain zinc_ribbon_2 PF13240.1 EFE45186.1 - 0.88 9.1 0.0 0.88 9.1 0.0 4.1 3 1 2 5 5 5 0 zinc-ribbon domain DUF948 PF06103.6 EFE45186.1 - 6.5 6.6 5.7 12 5.8 0.4 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TFR_dimer PF04253.10 EFE45188.1 - 9.2e-18 64.0 0.0 1.6e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 EFE45188.1 - 2.2e-15 56.8 0.0 5.7e-15 55.4 0.0 1.7 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EFE45188.1 - 1.7e-06 27.6 0.0 3.5e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.23 EFE45188.1 - 0.00043 19.8 0.0 0.00078 18.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 YHS PF04945.8 EFE45188.1 - 0.12 12.2 1.0 0.26 11.1 0.7 1.5 1 0 0 1 1 1 0 YHS domain zf-C2H2_4 PF13894.1 EFE45190.1 - 0.056 13.7 1.1 1.3 9.5 0.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger CMD PF02627.15 EFE45192.1 - 2.1e-09 37.0 0.1 6e-08 32.4 0.0 2.3 2 1 0 2 2 2 2 Carboxymuconolactone decarboxylase family CBFD_NFYB_HMF PF00808.18 EFE45193.1 - 2.9e-21 75.2 1.0 3.7e-21 74.9 0.7 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFE45193.1 - 0.00014 21.8 0.0 0.00022 21.2 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 EFE45193.1 - 0.0024 17.5 0.0 0.0036 17.0 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-18kDa PF02269.11 EFE45193.1 - 0.0042 16.8 0.0 0.0063 16.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TFIID_20kDa PF03847.8 EFE45193.1 - 0.1 12.9 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A DDHD PF02862.12 EFE45195.1 - 0.27 10.9 2.9 0.29 10.8 2.0 1.0 1 0 0 1 1 1 0 DDHD domain DUF2201_N PF13203.1 EFE45195.1 - 2.2 7.3 8.6 2.6 7.1 6.0 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Prefoldin_2 PF01920.15 EFE45196.1 - 3.8e-16 58.7 0.2 5.2e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Borrelia_lipo_1 PF05714.6 EFE45196.1 - 0.017 14.2 0.3 0.022 13.8 0.2 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Prefoldin PF02996.12 EFE45196.1 - 0.022 14.3 0.1 0.034 13.8 0.1 1.2 1 0 0 1 1 1 0 Prefoldin subunit hGDE_central PF14702.1 EFE45196.1 - 0.022 13.9 0.2 0.025 13.7 0.1 1.1 1 0 0 1 1 1 0 central domain of human glycogen debranching enzyme SMK-1 PF04802.10 EFE45196.1 - 0.096 12.2 0.5 0.24 10.8 0.1 1.7 2 0 0 2 2 2 0 Component of IIS longevity pathway SMK-1 PAP_central PF04928.12 EFE45196.1 - 0.1 11.3 0.4 0.29 9.9 0.2 1.8 1 1 0 1 1 1 0 Poly(A) polymerase central domain FUSC PF04632.7 EFE45196.1 - 0.13 10.6 0.2 0.13 10.6 0.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fungal_trans PF04082.13 EFE45197.1 - 3.6e-23 81.7 0.0 6.9e-23 80.8 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain TF_Zn_Ribbon PF08271.7 EFE45197.1 - 0.084 12.2 0.1 0.084 12.2 0.1 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding TFIIA PF03153.8 EFE45197.1 - 7.3 6.3 27.4 1.5 8.6 4.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit G-alpha PF00503.15 EFE45197.1 - 9.5 4.7 17.1 0.034 12.8 4.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Aminotran_1_2 PF00155.16 EFE45198.1 - 1.8e-19 69.9 0.0 2.5e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EFE45198.1 - 0.0046 16.1 0.0 0.0074 15.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.2 EFE45198.1 - 0.055 12.0 0.0 0.22 10.0 0.0 1.8 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.12 EFE45198.1 - 0.14 11.1 0.1 0.83 8.6 0.0 1.9 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Pkinase PF00069.20 EFE45199.1 - 1.9e-53 181.2 0.0 2.6e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE45199.1 - 1.2e-39 135.9 0.0 1.9e-39 135.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE45199.1 - 0.00087 18.3 0.0 0.0014 17.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFE45199.1 - 0.002 17.2 0.1 0.0065 15.5 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EFE45201.1 - 1.9e-70 237.0 0.0 3e-70 236.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFE45201.1 - 8.7e-35 120.0 0.1 2e-34 118.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFE45201.1 - 0.00015 20.8 0.0 0.00023 20.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 EFE45201.1 - 0.004 16.5 0.0 0.014 14.7 0.0 1.9 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.9 EFE45201.1 - 0.0083 15.2 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFE45201.1 - 0.084 12.5 0.1 0.27 10.9 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Methyltransf_8 PF05148.10 EFE45202.1 - 5.3e-58 196.2 0.4 2.5e-54 184.2 0.0 2.8 3 0 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_11 PF08241.7 EFE45202.1 - 7.3e-07 29.6 0.0 2.4e-06 27.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFE45202.1 - 0.012 16.0 0.0 0.62 10.4 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 EFE45202.1 - 0.025 14.2 0.0 0.063 12.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF2924 PF11149.3 EFE45202.1 - 0.077 13.0 0.3 0.22 11.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) Proteasome PF00227.21 EFE45203.1 - 4.7e-57 192.3 0.1 6.3e-57 191.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFE45203.1 - 3.6e-10 38.9 1.4 6.1e-10 38.2 0.3 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF3137 PF11335.3 EFE45203.1 - 0.019 14.6 0.1 0.68 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3137) Spc97_Spc98 PF04130.8 EFE45204.1 - 3.2e-134 448.2 0.1 3.9e-134 447.9 0.1 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family DUF3346 PF11826.3 EFE45204.1 - 0.0085 15.8 1.1 0.016 14.9 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3346) KH_1 PF00013.24 EFE45205.1 - 0.011 15.3 0.8 0.23 11.1 0.0 3.0 3 0 0 3 3 3 0 KH domain KH_3 PF13014.1 EFE45205.1 - 0.02 14.5 0.1 0.25 11.0 0.0 2.7 3 0 0 3 3 3 0 KH domain adh_short PF00106.20 EFE45207.1 - 1.6e-23 83.4 0.0 2.2e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFE45207.1 - 1.1e-10 41.6 0.0 1.7e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFE45207.1 - 3.6e-07 30.0 0.0 5.3e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFE45207.1 - 0.00046 20.2 0.0 0.00079 19.4 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 EFE45207.1 - 0.0011 17.9 0.0 0.0018 17.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EFE45207.1 - 0.0031 16.9 0.0 0.0046 16.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EFE45207.1 - 0.059 12.6 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family 3HCDH_N PF02737.13 EFE45207.1 - 0.075 12.6 0.1 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GalP_UDP_tr_C PF02744.12 EFE45208.1 - 3.6e-38 130.7 2.9 6.5e-36 123.3 1.5 2.5 1 1 1 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.17 EFE45208.1 - 1.5e-34 119.7 0.0 1e-32 113.6 0.0 2.7 2 1 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain