# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- OrsD PF12013.8 EEA18456.1 - 2.9e-12 47.0 9.6 2.9e-12 47.0 9.6 2.4 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA18456.1 - 3.4e-11 43.2 0.0 1.1e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA18456.1 - 0.00054 20.0 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_S8 PF00082.22 EEA18456.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Subtilase family zf-C2H2_12 PF18658.1 EEA18456.1 - 1.8 8.2 8.7 0.14 11.8 3.0 2.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type OrsD PF12013.8 EEA18457.1 - 2.9e-12 47.0 9.6 2.9e-12 47.0 9.6 2.4 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA18457.1 - 3.3e-11 43.2 0.0 1.1e-10 41.5 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA18457.1 - 0.00053 20.0 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_S8 PF00082.22 EEA18457.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Subtilase family zf-C2H2_12 PF18658.1 EEA18457.1 - 1.8 8.2 8.7 0.14 11.8 3.0 2.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type OrsD PF12013.8 EEA18458.1 - 2.8e-12 47.1 12.4 2.9e-12 47.0 9.6 2.5 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA18458.1 - 3.4e-11 43.2 0.0 1.1e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA18458.1 - 0.00053 20.0 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_S8 PF00082.22 EEA18458.1 - 0.094 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Subtilase family zf-C2H2_12 PF18658.1 EEA18458.1 - 1.7 8.2 8.7 0.14 11.8 3.0 2.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type Asp PF00026.23 EEA18459.1 - 2.6e-40 138.8 0.2 3e-40 138.6 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA18459.1 - 1.5e-05 25.3 0.0 0.0058 16.9 0.0 3.0 2 1 1 3 3 3 1 Xylanase inhibitor N-terminal Dus PF01207.17 EEA18459.1 - 0.16 11.0 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) HsbA PF12296.8 EEA18460.1 - 1.1e-13 51.6 0.0 1.8e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A OrsD PF12013.8 EEA18461.1 - 3.9e-12 46.6 12.4 4.2e-12 46.5 9.6 2.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D Helicase_C PF00271.31 EEA18461.1 - 8.2e-12 45.5 0.0 1e-10 41.9 0.0 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA18461.1 - 4.6e-11 42.8 0.0 1.7e-10 41.0 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA18461.1 - 0.00085 19.4 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EEA18461.1 - 0.0091 16.7 0.1 0.032 14.9 0.1 2.0 1 0 0 1 1 1 1 RecQ zinc-binding zf-C2H2_12 PF18658.1 EEA18461.1 - 0.035 13.7 3.0 0.19 11.3 3.0 2.3 1 0 0 1 1 1 0 Zinc-finger C2H2-type Peptidase_S8 PF00082.22 EEA18461.1 - 0.13 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Subtilase family LA-virus_coat PF09220.10 EEA18462.1 - 1.3e-207 689.8 2.0 1.6e-207 689.5 2.0 1.1 1 0 0 1 1 1 1 L-A virus, major coat protein Herpes_HEPA PF03324.14 EEA18462.1 - 0.0055 17.1 0.2 0.011 16.1 0.2 1.5 1 0 0 1 1 1 1 Herpesvirus DNA helicase/primase complex associated protein OrsD PF12013.8 EEA18464.1 - 4.9e-10 39.9 1.3 9.8e-10 38.9 0.2 2.0 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_12 PF18658.1 EEA18464.1 - 0.0023 17.4 0.1 0.06 12.9 0.0 2.7 3 0 0 3 3 3 1 Zinc-finger C2H2-type zf-BED PF02892.15 EEA18464.1 - 0.032 14.3 0.9 0.032 14.3 0.9 2.7 3 0 0 3 3 3 0 BED zinc finger ITAM PF02189.15 EEA18464.1 - 1.2 9.8 3.9 20 5.9 0.2 3.7 3 1 1 4 4 4 0 Immunoreceptor tyrosine-based activation motif HTH_32 PF13565.6 EEA18465.1 - 4e-05 24.1 1.2 0.049 14.2 0.3 2.2 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 EEA18465.1 - 0.00069 19.3 0.2 0.0011 18.7 0.2 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.6 EEA18465.1 - 0.0022 17.7 0.1 0.0045 16.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.15 EEA18465.1 - 0.0059 16.7 0.0 1.6 8.9 0.0 2.2 2 0 0 2 2 2 2 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA18465.1 - 0.041 14.1 0.0 0.062 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Cytochrom_C PF00034.21 EEA18465.1 - 0.056 14.6 0.0 0.11 13.7 0.0 1.6 1 1 0 1 1 1 0 Cytochrome c Sigma70_r4_2 PF08281.12 EEA18465.1 - 0.07 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 DUF4192 PF13830.6 EEA18466.1 - 1.5 8.9 3.4 0.79 9.7 0.6 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4192) Exo_endo_phos_2 PF14529.6 EEA18467.1 - 1.1e-07 31.7 0.1 2.4e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 EEA18467.1 - 1.8e-06 27.6 0.0 3.4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EEA18467.1 - 5.1e-06 26.7 0.0 9.7e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 RNase H Toxin_trans PF07952.12 EEA18467.1 - 0.12 11.4 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain Bys1 PF04681.12 EEA18469.1 - 7.3e-05 22.8 0.0 9e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein SH3_17 PF18350.1 EEA18473.1 - 0.041 13.8 0.1 0.066 13.1 0.1 1.3 1 0 0 1 1 1 0 Restriction endonuclease SH3 domain Myb_DNA-bind_6 PF13921.6 EEA18474.1 - 1.2e-07 31.8 0.2 2.7e-07 30.8 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA18474.1 - 4.1e-05 23.7 0.2 7.4e-05 22.9 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain APH PF01636.23 EEA18475.1 - 2.7e-11 43.9 0.0 4.9e-11 43.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Casc1_N PF15927.5 EEA18476.1 - 0.67 9.6 16.8 0.78 9.4 16.8 1.0 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus U79_P34 PF03064.16 EEA18476.1 - 0.69 9.2 9.2 0.74 9.1 9.2 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF3043 PF11241.8 EEA18476.1 - 2.2 8.3 9.8 2.5 8.1 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF4574 PF15141.6 EEA18476.1 - 2.6 8.0 8.9 6.6 6.7 8.9 1.6 1 1 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 UvrB PF12344.8 EEA18476.1 - 4.9 7.1 12.2 4.2 7.3 1.9 2.3 2 0 0 2 2 2 0 Ultra-violet resistance protein B Connexin PF00029.19 EEA18476.1 - 8.1 6.1 5.4 8.3 6.1 5.4 1.0 1 0 0 1 1 1 0 Connexin Pkinase PF00069.25 EEA18477.1 - 3e-18 66.1 0.0 4e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA18477.1 - 5.8e-17 61.8 0.0 2.1e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA18477.1 - 0.0037 16.6 0.0 0.0075 15.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA18477.1 - 0.0062 15.9 0.0 0.018 14.4 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family LCIB_C_CA PF18599.1 EEA18479.1 - 0.1 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases BCS1_N PF08740.11 EEA18483.1 - 8.4e-27 94.4 0.3 1.6e-26 93.4 0.3 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EEA18483.1 - 4.2e-17 62.8 0.0 7.5e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EEA18483.1 - 0.035 14.6 0.8 0.15 12.6 0.3 2.4 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EEA18483.1 - 0.089 13.2 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase RuvB_N PF05496.12 EEA18483.1 - 0.097 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain PPV_E1_C PF00519.17 EEA18483.1 - 0.11 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 EEA18483.1 - 0.13 12.3 0.1 0.54 10.2 0.1 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) zf-C2H2_4 PF13894.6 EEA18485.1 - 0.0096 16.7 0.9 0.0096 16.7 0.9 4.0 5 0 0 5 5 5 1 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EEA18485.1 - 0.034 14.1 0.5 0.1 12.6 0.5 1.9 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-Di19 PF05605.12 EEA18485.1 - 0.044 14.1 0.0 0.044 14.1 0.0 2.7 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EEA18485.1 - 0.076 13.5 1.3 0.076 13.5 1.3 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type APH PF01636.23 EEA18486.1 - 2.1e-05 24.6 0.0 2.1e-05 24.6 0.0 2.9 3 0 0 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA18486.1 - 0.00011 21.9 1.4 0.00039 20.1 0.0 2.3 3 0 0 3 3 3 1 Choline/ethanolamine kinase Otopetrin PF03189.13 EEA18486.1 - 0.0011 17.9 0.0 0.013 14.4 0.0 2.1 1 1 0 1 1 1 1 Otopetrin HSDR_N_2 PF13588.6 EEA18486.1 - 0.017 15.1 0.0 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase PF00069.25 EEA18486.1 - 0.02 14.3 0.0 0.042 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain WaaY PF06176.11 EEA18486.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) eIF3_subunit PF08597.10 EEA18486.1 - 0.87 9.4 17.4 0.7 9.8 11.6 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit V_ATPase_I PF01496.19 EEA18486.1 - 2.6 5.9 5.4 3.6 5.4 5.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CPSF100_C PF13299.6 EEA18486.1 - 5.2 7.2 8.1 7.5 6.7 5.5 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal GBP_C PF02841.14 EEA18486.1 - 6.7 6.0 14.9 14 5.0 14.9 1.5 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain RNA_pol_Rpc4 PF05132.14 EEA18486.1 - 9.1 6.7 6.7 62 4.0 0.1 2.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 APH PF01636.23 EEA18487.1 - 7.4e-13 49.0 0.0 1.6e-12 47.9 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA18487.1 - 7.2e-10 38.8 0.0 1.8e-09 37.5 0.0 1.7 1 1 0 1 1 1 1 Choline/ethanolamine kinase HEAT_2 PF13646.6 EEA18488.1 - 7e-82 269.9 33.2 9.9e-17 61.1 1.0 6.8 5 1 1 6 6 6 6 HEAT repeats HEAT PF02985.22 EEA18488.1 - 3.2e-55 179.4 12.6 0.012 15.8 0.0 15.8 15 0 0 15 15 15 12 HEAT repeat HEAT_EZ PF13513.6 EEA18488.1 - 3.2e-33 113.7 19.5 0.012 16.0 0.5 14.5 8 4 8 16 16 15 9 HEAT-like repeat DUF3385 PF11865.8 EEA18488.1 - 7.6e-17 61.7 0.0 3.7 7.4 0.0 12.3 13 1 0 13 13 13 2 Domain of unknown function (DUF3385) Cohesin_HEAT PF12765.7 EEA18488.1 - 1.8e-16 60.1 25.2 0.58 10.5 0.0 12.8 13 0 0 13 13 13 4 HEAT repeat associated with sister chromatid cohesion HEAT_PBS PF03130.16 EEA18488.1 - 7.4e-15 54.1 44.1 3.3 8.7 0.1 15.4 15 0 0 15 15 15 1 PBS lyase HEAT-like repeat NACHT PF05729.12 EEA18488.1 - 1.5e-13 51.0 0.1 2.9e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Adaptin_N PF01602.20 EEA18488.1 - 2.8e-10 39.4 0.0 1.1e-06 27.5 0.0 3.8 1 1 1 2 2 2 1 Adaptin N terminal region PNP_UDP_1 PF01048.20 EEA18488.1 - 4.6e-08 32.6 0.0 7.9e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily NLRC4_HD2 PF17776.1 EEA18488.1 - 9.2e-08 32.7 0.1 3.2e-07 30.9 0.1 2.0 1 0 0 1 1 1 1 NLRC4 helical domain HD2 NB-ARC PF00931.22 EEA18488.1 - 9.3e-08 31.6 0.0 2.4e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain CO_deh_flav_C PF03450.17 EEA18488.1 - 1.1e-06 28.7 2.7 45 4.3 0.0 9.0 3 1 5 10 10 10 0 CO dehydrogenase flavoprotein C-terminal domain Vac14_Fab1_bd PF12755.7 EEA18488.1 - 6.7e-06 26.6 1.3 12 6.6 0.0 7.9 4 3 2 7 7 7 0 Vacuolar 14 Fab1-binding region AAA_16 PF13191.6 EEA18488.1 - 0.00015 22.2 5.7 0.022 15.1 0.0 5.6 3 1 1 4 4 4 1 AAA ATPase domain EPL1 PF10513.9 EEA18488.1 - 0.00019 21.9 0.0 6.9 7.0 0.0 7.1 6 5 0 6 6 6 0 Enhancer of polycomb-like DNA_alkylation PF08713.11 EEA18488.1 - 0.00023 21.0 9.6 0.024 14.4 1.7 3.8 2 1 1 3 3 3 2 DNA alkylation repair enzyme Arm PF00514.23 EEA18488.1 - 0.00035 20.5 0.0 2e+02 2.2 0.0 7.5 9 0 0 9 9 8 0 Armadillo/beta-catenin-like repeat AAA_22 PF13401.6 EEA18488.1 - 0.00062 20.0 0.0 0.0027 18.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain Nore1-SARAH PF16517.5 EEA18488.1 - 0.0012 18.7 0.0 17 5.4 0.0 6.5 8 0 0 8 8 7 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Cnd3 PF12719.7 EEA18488.1 - 0.0033 16.7 0.2 39 3.3 0.0 6.1 3 3 2 5 5 5 0 Nuclear condensing complex subunits, C-term domain AAA PF00004.29 EEA18488.1 - 0.021 15.3 0.0 0.075 13.5 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EEA18488.1 - 0.043 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 EEA18488.1 - 0.054 14.1 0.0 0.23 12.0 0.0 2.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA18488.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EEA18488.1 - 0.17 11.9 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA18488.1 - 0.19 11.6 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EEA18488.1 - 0.19 12.1 0.7 2.9 8.3 0.1 3.3 3 1 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EEA18488.1 - 0.23 11.2 0.0 0.43 10.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation HEAT_2 PF13646.6 EEA18489.1 - 6.7e-82 270.0 33.2 9.8e-17 61.1 1.0 6.8 5 1 1 6 6 6 6 HEAT repeats HEAT PF02985.22 EEA18489.1 - 2.9e-55 179.5 12.6 0.012 15.8 0.0 15.8 15 0 0 15 15 15 12 HEAT repeat HEAT_EZ PF13513.6 EEA18489.1 - 3e-33 113.8 19.5 0.012 16.1 0.5 14.5 8 4 8 16 16 15 9 HEAT-like repeat DUF3385 PF11865.8 EEA18489.1 - 7.1e-17 61.8 0.0 3.6 7.5 0.0 12.4 13 1 0 13 13 13 2 Domain of unknown function (DUF3385) Cohesin_HEAT PF12765.7 EEA18489.1 - 1.7e-16 60.2 25.2 0.58 10.5 0.0 12.8 13 0 0 13 13 13 4 HEAT repeat associated with sister chromatid cohesion HEAT_PBS PF03130.16 EEA18489.1 - 6.7e-15 54.2 44.1 3.3 8.7 0.1 15.4 15 0 0 15 15 15 1 PBS lyase HEAT-like repeat NACHT PF05729.12 EEA18489.1 - 1.5e-13 51.0 0.1 2.8e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Adaptin_N PF01602.20 EEA18489.1 - 2.7e-10 39.4 0.0 1.1e-06 27.5 0.0 3.8 1 1 1 2 2 2 1 Adaptin N terminal region PNP_UDP_1 PF01048.20 EEA18489.1 - 4.5e-08 32.6 0.0 7.8e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily NLRC4_HD2 PF17776.1 EEA18489.1 - 9.1e-08 32.7 0.1 3.2e-07 31.0 0.1 2.0 1 0 0 1 1 1 1 NLRC4 helical domain HD2 NB-ARC PF00931.22 EEA18489.1 - 9.2e-08 31.6 0.0 2.4e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain CO_deh_flav_C PF03450.17 EEA18489.1 - 1.1e-06 28.8 2.7 44 4.3 0.0 9.0 3 1 5 10 10 10 0 CO dehydrogenase flavoprotein C-terminal domain Vac14_Fab1_bd PF12755.7 EEA18489.1 - 6.5e-06 26.7 1.3 12 6.6 0.0 7.9 4 3 3 8 8 6 0 Vacuolar 14 Fab1-binding region AAA_16 PF13191.6 EEA18489.1 - 0.00013 22.4 5.6 0.022 15.1 0.0 5.6 3 1 0 3 3 3 1 AAA ATPase domain EPL1 PF10513.9 EEA18489.1 - 0.00018 21.9 0.0 6.9 7.0 0.0 7.1 6 5 0 6 6 6 0 Enhancer of polycomb-like DNA_alkylation PF08713.11 EEA18489.1 - 0.00024 20.9 9.7 0.024 14.4 1.7 3.8 2 1 1 3 3 3 2 DNA alkylation repair enzyme Arm PF00514.23 EEA18489.1 - 0.00033 20.6 0.0 2e+02 2.2 0.0 7.5 9 0 0 9 9 8 0 Armadillo/beta-catenin-like repeat AAA_22 PF13401.6 EEA18489.1 - 0.00061 20.1 0.0 0.0026 18.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain Nore1-SARAH PF16517.5 EEA18489.1 - 0.0012 18.7 0.0 17 5.4 0.0 6.5 8 0 0 8 8 7 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Cnd3 PF12719.7 EEA18489.1 - 0.0032 16.7 0.2 38 3.3 0.0 6.1 3 3 2 5 5 5 0 Nuclear condensing complex subunits, C-term domain AAA PF00004.29 EEA18489.1 - 0.02 15.3 0.0 0.075 13.5 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EEA18489.1 - 0.043 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 EEA18489.1 - 0.053 14.1 0.0 0.23 12.0 0.0 2.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA18489.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EEA18489.1 - 0.17 11.9 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA18489.1 - 0.19 11.6 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EEA18489.1 - 0.19 12.1 0.7 2.9 8.3 0.1 3.3 3 1 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EEA18489.1 - 0.22 11.2 0.0 0.43 10.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation API5 PF05918.11 EEA18489.1 - 4.1 6.1 4.3 57 2.3 0.1 4.0 4 2 0 4 4 4 0 Apoptosis inhibitory protein 5 (API5) RVT_1 PF00078.27 EEA18490.1 - 3.5e-36 124.8 0.0 7e-36 123.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA18490.1 - 6.5e-25 87.3 0.0 2.2e-24 85.6 0.0 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-CCHC PF00098.23 EEA18490.1 - 0.00024 21.0 2.6 0.00024 21.0 2.6 2.6 2 0 0 2 2 2 1 Zinc knuckle Spc7 PF08317.11 EEA18490.1 - 0.051 12.5 4.8 0.097 11.5 4.1 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein DBINO PF13892.6 EEA18490.1 - 0.12 12.7 4.5 2.2 8.6 1.0 3.0 2 0 0 2 2 2 0 DNA-binding domain zf-RVT PF13966.6 EEA18490.1 - 0.24 12.2 0.1 0.24 12.2 0.1 3.0 3 0 0 3 3 3 0 zinc-binding in reverse transcriptase WD40 PF00400.32 EEA18492.1 - 3.5e-139 448.5 39.5 1.3e-10 41.7 0.0 14.8 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18492.1 - 1.2e-48 163.3 4.1 0.00079 19.7 0.0 12.9 1 1 11 12 12 12 11 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA18492.1 - 4.8e-20 72.3 0.0 1.2e-06 28.5 0.0 5.3 1 1 5 6 6 6 6 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA18492.1 - 9e-18 64.3 8.8 0.92 8.4 0.0 11.8 1 1 11 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EEA18492.1 - 3.5e-14 52.8 0.0 0.0057 16.0 0.0 6.8 4 2 3 7 7 7 4 WD40-like domain Proteasome_A_N PF10584.9 EEA18492.1 - 1.9e-13 49.8 0.0 7.5 6.3 0.0 10.0 9 0 0 9 9 8 0 Proteasome subunit A N-terminal signature PD40 PF07676.12 EEA18492.1 - 3.7e-12 45.8 1.1 13 5.9 0.0 10.4 11 0 0 11 11 10 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 EEA18492.1 - 1.4e-09 38.1 0.0 3.2e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 EEA18492.1 - 2.9e-09 36.5 0.2 1.2e-08 34.6 0.2 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily Ret2_MD PF18528.1 EEA18492.1 - 3e-09 37.1 0.0 8.6 6.8 0.0 9.3 7 2 4 11 11 10 0 RNA editing 3' terminal uridylyl transferase 2 middle domain AAA_16 PF13191.6 EEA18492.1 - 1.2e-08 35.5 0.0 5.4e-08 33.4 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain DUF4784 PF16023.5 EEA18492.1 - 3.1e-08 33.0 0.2 9.3 5.1 0.0 7.2 4 2 3 8 8 8 0 Domain of unknown function (DUF4784) IKI3 PF04762.12 EEA18492.1 - 6.4e-07 27.8 2.4 0.14 10.1 0.4 4.9 2 2 1 4 4 4 2 IKI3 family Cytochrom_D1 PF02239.16 EEA18492.1 - 6.6e-07 28.2 0.2 0.16 10.5 0.0 4.7 1 1 4 6 6 6 3 Cytochrome D1 heme domain DUF5122 PF17164.4 EEA18492.1 - 2.3e-06 27.8 12.2 12 6.3 0.0 9.1 9 0 0 9 9 9 0 Domain of unknown function (DUF5122) beta-propeller DUF5046 PF16465.5 EEA18492.1 - 4.9e-05 22.9 0.1 0.3 10.5 0.0 4.1 1 1 4 5 5 5 2 Domain of unknown function (DUF5046) DUF1513 PF07433.11 EEA18492.1 - 0.00014 21.0 3.9 6.3 5.8 0.0 5.4 1 1 4 6 6 6 1 Protein of unknown function (DUF1513) AAA PF00004.29 EEA18492.1 - 0.003 18.0 0.0 0.01 16.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MORN_2 PF07661.13 EEA18492.1 - 0.0046 17.0 0.0 27 5.4 0.0 6.3 8 0 0 8 8 5 0 MORN repeat variant Stimulus_sens_1 PF13756.6 EEA18492.1 - 0.021 15.4 0.0 92 3.7 0.0 5.1 6 0 0 6 6 4 0 Stimulus-sensing domain Lactonase PF10282.9 EEA18492.1 - 0.041 13.1 0.1 2.9 7.1 0.0 3.3 2 2 1 4 4 4 0 Lactonase, 7-bladed beta-propeller AAA_30 PF13604.6 EEA18492.1 - 0.049 13.4 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA18492.1 - 0.056 14.0 0.0 0.17 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EEA18492.1 - 0.056 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase NB-ARC PF00931.22 EEA18492.1 - 0.081 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain PIF1 PF05970.14 EEA18492.1 - 0.14 11.3 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase RXT2_N PF08595.11 EEA18493.1 - 0.025 14.6 0.3 0.037 14.0 0.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4611 PF15387.6 EEA18493.1 - 0.18 12.0 2.5 0.48 10.7 2.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Cwf_Cwc_15 PF04889.12 EEA18493.1 - 0.74 9.5 7.4 1.2 8.9 7.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 EEA18493.1 - 1.6 7.8 11.4 2.8 7.0 11.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.10 EEA18493.1 - 2 8.9 15.0 0.17 12.3 9.9 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF2076 PF09849.9 EEA18493.1 - 6.6 6.7 5.8 11 6.0 5.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RXT2_N PF08595.11 EEA18494.1 - 0.027 14.5 0.4 0.042 13.9 0.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4611 PF15387.6 EEA18494.1 - 0.18 12.0 2.5 0.47 10.7 2.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF2457 PF10446.9 EEA18494.1 - 1.5 7.8 11.3 2.6 7.1 11.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.10 EEA18494.1 - 1.9 8.9 15.0 0.16 12.4 9.9 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EEA18494.1 - 2.3 7.9 9.0 3.8 7.2 9.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EEA18494.1 - 9.9 5.4 12.4 17 4.7 12.4 1.2 1 0 0 1 1 1 0 NOA36 protein BTB PF00651.31 EEA18495.1 - 0.0079 16.4 0.0 0.021 15.1 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain Piwi PF02171.17 EEA18496.1 - 8.7e-72 241.9 0.0 1.4e-71 241.3 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EEA18496.1 - 6.4e-16 59.2 0.1 1.4e-15 58.1 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EEA18496.1 - 8.9e-16 57.3 0.3 3e-15 55.6 0.3 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EEA18496.1 - 7.5e-11 42.2 0.0 2.5e-09 37.3 0.0 2.9 2 0 0 2 2 2 1 Argonaute linker 2 domain PAZ PF02170.22 EEA18496.1 - 1.6e-08 34.4 0.0 3.5e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 PAZ domain Prefoldin_3 PF13758.6 EEA18497.1 - 0.14 12.3 1.7 10 6.3 0.1 2.9 3 0 0 3 3 3 0 Prefoldin subunit TBCC_N PF16752.5 EEA18497.1 - 2.2 8.8 10.0 0.15 12.5 1.4 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain IBR PF01485.21 EEA18498.1 - 1.8e-16 60.1 37.5 3.8e-09 36.6 8.6 3.6 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain CCDC50_N PF15295.6 EEA18498.1 - 0.51 10.5 0.1 0.51 10.5 0.1 2.7 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 50 N-terminus IBR PF01485.21 EEA18499.1 - 3e-14 53.0 56.3 3.6e-09 36.7 8.6 4.5 4 1 0 4 4 4 3 IBR domain, a half RING-finger domain CCDC50_N PF15295.6 EEA18499.1 - 0.48 10.6 0.1 0.48 10.6 0.1 2.7 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 50 N-terminus TadE PF07811.12 EEA18501.1 - 6.4 7.1 11.9 0.17 12.2 1.8 2.2 2 0 0 2 2 2 0 TadE-like protein zf-C3HC4_3 PF13920.6 EEA18504.1 - 4.5e-06 26.4 6.0 6.8e-06 25.8 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA18504.1 - 1.3e-05 25.1 5.3 3e-05 24.0 5.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger APG6_N PF17675.1 EEA18504.1 - 0.00013 22.6 16.7 0.0002 21.9 16.7 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region Tho2 PF11262.8 EEA18504.1 - 0.0002 20.7 7.3 0.00026 20.3 7.3 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Exonuc_VII_L PF02601.15 EEA18504.1 - 0.00039 20.1 8.4 0.00047 19.8 8.4 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit zf-C3HC4 PF00097.25 EEA18504.1 - 0.00041 20.2 5.1 0.0008 19.2 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA18504.1 - 0.0015 18.3 3.2 0.0032 17.3 3.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA18504.1 - 0.0017 18.3 6.6 0.0029 17.5 6.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Spc7 PF08317.11 EEA18504.1 - 0.0018 17.2 18.3 0.0028 16.6 18.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein KASH_CCD PF14662.6 EEA18504.1 - 0.0027 17.6 18.1 0.0038 17.1 18.1 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Prok-RING_4 PF14447.6 EEA18504.1 - 0.004 17.0 3.4 0.012 15.5 3.5 1.8 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EEA18504.1 - 0.0047 17.2 5.8 0.0081 16.5 5.8 1.4 1 0 0 1 1 1 1 Ring finger domain ERM PF00769.19 EEA18504.1 - 0.0073 16.1 16.1 0.011 15.6 16.1 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family zf-C3HC4_4 PF15227.6 EEA18504.1 - 0.0078 16.3 5.0 0.033 14.3 5.3 2.0 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING GAS PF13851.6 EEA18504.1 - 0.0092 15.4 21.2 0.013 14.9 21.2 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding zf-C3HC4_5 PF17121.5 EEA18504.1 - 0.011 15.6 4.4 0.019 14.8 4.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ax_dynein_light PF10211.9 EEA18504.1 - 0.015 15.2 15.5 0.023 14.6 15.5 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain DUF3450 PF11932.8 EEA18504.1 - 0.017 14.4 17.1 0.024 14.0 17.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1351 PF07083.11 EEA18504.1 - 0.021 14.6 11.0 0.029 14.1 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) UPF0242 PF06785.11 EEA18504.1 - 0.025 14.7 20.5 0.034 14.3 20.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-RING_6 PF14835.6 EEA18504.1 - 0.032 14.1 2.3 0.06 13.2 2.3 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Golgin_A5 PF09787.9 EEA18504.1 - 0.041 13.3 17.2 0.058 12.9 17.2 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF3584 PF12128.8 EEA18504.1 - 0.054 11.0 15.1 0.068 10.7 15.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_23 PF13476.6 EEA18504.1 - 0.063 13.8 12.8 0.094 13.2 12.8 1.3 1 0 0 1 1 1 0 AAA domain COG5 PF10392.9 EEA18504.1 - 0.08 13.1 8.6 0.24 11.6 0.1 2.2 1 1 0 2 2 2 0 Golgi transport complex subunit 5 ADIP PF11559.8 EEA18504.1 - 0.094 12.8 20.3 0.14 12.3 20.3 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding V_ATPase_I PF01496.19 EEA18504.1 - 0.1 10.5 8.8 0.13 10.2 8.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-C4H2 PF10146.9 EEA18504.1 - 0.13 12.5 11.6 0.23 11.7 11.6 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein FapA PF03961.13 EEA18504.1 - 0.14 10.7 12.4 0.18 10.4 12.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A JIP_LZII PF16471.5 EEA18504.1 - 0.14 12.3 12.8 0.28 11.4 12.8 1.5 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II FTO_NTD PF12933.7 EEA18504.1 - 0.18 11.0 3.5 0.24 10.6 3.5 1.1 1 0 0 1 1 1 0 FTO catalytic domain Jnk-SapK_ap_N PF09744.9 EEA18504.1 - 0.25 11.5 18.2 0.49 10.6 18.2 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Prominin PF05478.11 EEA18504.1 - 0.25 9.2 5.2 0.32 8.9 5.2 1.1 1 0 0 1 1 1 0 Prominin Macoilin PF09726.9 EEA18504.1 - 0.38 9.2 11.7 0.45 9.0 11.7 1.0 1 0 0 1 1 1 0 Macoilin family 5_nucleotid PF05761.14 EEA18504.1 - 0.49 9.2 9.7 0.69 8.7 9.7 1.2 1 0 0 1 1 1 0 5' nucleotidase family HALZ PF02183.18 EEA18504.1 - 0.67 10.2 27.0 1.1 9.6 3.9 2.9 1 1 2 3 3 3 0 Homeobox associated leucine zipper CENP-H PF05837.12 EEA18504.1 - 1 9.8 14.4 1.7 9.1 14.4 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Dor1 PF04124.12 EEA18504.1 - 1.1 7.9 16.1 1.6 7.4 5.9 2.8 1 1 2 3 3 3 0 Dor1-like family HemX PF04375.14 EEA18504.1 - 1.3 8.2 16.0 1.8 7.8 16.0 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase FemAB PF02388.16 EEA18504.1 - 1.4 7.8 9.9 1.8 7.4 9.9 1.1 1 0 0 1 1 1 0 FemAB family DUF4795 PF16043.5 EEA18504.1 - 1.4 8.5 19.1 0.46 10.1 11.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) TMPIT PF07851.13 EEA18504.1 - 1.7 7.8 13.1 2.3 7.4 13.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 EEA18504.1 - 1.8 8.6 11.6 3.7 7.6 11.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) NRBF2 PF08961.10 EEA18504.1 - 2 8.0 17.9 0.41 10.2 7.0 2.5 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator DivIVA PF05103.13 EEA18504.1 - 2.2 8.3 17.6 0.19 11.8 6.1 2.2 1 1 1 2 2 2 0 DivIVA protein AAA_11 PF13086.6 EEA18504.1 - 2.3 7.9 12.1 3 7.5 12.1 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 EEA18504.1 - 2.4 6.8 3.9 2.6 6.7 3.9 1.1 1 0 0 1 1 1 0 Presenilin DUF3552 PF12072.8 EEA18504.1 - 3.2 7.1 22.9 4.5 6.6 22.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) YabA PF06156.13 EEA18504.1 - 3.8 8.2 17.6 7 7.4 5.0 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Prefoldin_2 PF01920.20 EEA18504.1 - 5.3 7.0 27.4 4.1 7.4 11.3 2.3 1 1 1 2 2 2 0 Prefoldin subunit DUF1943 PF09172.11 EEA18504.1 - 5.5 6.1 10.1 9.4 5.4 10.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1943) Seryl_tRNA_N PF02403.22 EEA18504.1 - 6.3 7.1 19.5 10 6.4 19.5 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain UPF0449 PF15136.6 EEA18504.1 - 6.4 7.3 20.7 20 5.7 10.1 2.8 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Neur_chan_memb PF02932.16 EEA18504.1 - 6.7 6.7 5.3 8.8 6.3 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 EEA18504.1 - 7.1 5.9 11.9 9.9 5.4 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 EEA18504.1 - 7.9 5.3 6.3 9.5 5.0 6.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SseC PF04888.12 EEA18504.1 - 8 6.0 8.3 11 5.5 8.3 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF2968 PF11180.8 EEA18504.1 - 8.4 6.0 24.2 13 5.3 24.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) DUF3435 PF11917.8 EEA18505.1 - 7.5e-152 506.1 2.1 7.5e-152 506.1 2.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) CDC45 PF02724.14 EEA18505.1 - 1.4 7.1 9.3 0.036 12.4 2.2 1.8 2 0 0 2 2 2 0 CDC45-like protein Bys1 PF04681.12 EEA18506.1 - 1.4e-07 31.6 0.0 1.9e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein zf-C2H2_10 PF16588.5 EEA18507.1 - 0.0047 16.6 1.2 0.0084 15.8 1.2 1.3 1 0 0 1 1 1 1 C2H2 zinc-finger GlnD_UR_UTase PF08335.11 EEA18507.1 - 0.011 15.8 0.7 0.015 15.4 0.7 1.1 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase zf-CCHC_4 PF14392.6 EEA18507.1 - 0.036 13.8 0.1 0.053 13.3 0.1 1.2 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EEA18507.1 - 0.087 12.9 2.1 0.14 12.3 2.1 1.3 1 0 0 1 1 1 0 Zinc knuckle DDE_1 PF03184.19 EEA18508.1 - 1.4e-15 57.4 0.0 1.9e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA18508.1 - 0.0003 20.7 0.3 0.00078 19.4 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EEA18508.1 - 0.1 12.4 0.0 0.38 10.5 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease DUF4939 PF16297.5 EEA18509.1 - 1.2e-07 31.6 0.0 2.5e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC PF00098.23 EEA18509.1 - 8.6e-05 22.4 4.1 0.00014 21.8 4.1 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EEA18509.1 - 0.0068 16.3 3.4 0.016 15.2 3.4 1.7 1 0 0 1 1 1 1 Zinc knuckle DUF1489 PF07370.11 EEA18509.1 - 0.051 13.3 0.3 0.095 12.4 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) zf-CCHC_5 PF14787.6 EEA18509.1 - 0.087 12.6 1.5 0.18 11.5 1.1 1.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 EEA18509.1 - 0.12 12.2 2.1 0.19 11.6 2.1 1.3 1 0 0 1 1 1 0 Zinc knuckle Pox_A_type_inc PF04508.12 EEA18509.1 - 0.96 9.4 0.0 0.96 9.4 0.0 2.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Helicase_C PF00271.31 EEA18510.1 - 1.1e-11 45.0 0.0 9.7e-11 42.0 0.0 2.4 1 1 1 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA18510.1 - 7.7e-09 35.6 0.0 3e-08 33.7 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 EEA18510.1 - 0.0014 19.0 3.4 0.0027 18.1 1.3 2.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 EEA18510.1 - 0.02 14.9 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EEA18510.1 - 0.045 14.5 0.2 0.16 12.7 0.2 2.0 1 0 0 1 1 1 0 RecQ zinc-binding Peptidase_S8 PF00082.22 EEA18510.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Subtilase family DEAD PF00270.29 EEA18511.1 - 1.4e-13 51.0 1.0 1.9e-13 50.6 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA18511.1 - 2.8e-12 46.9 0.1 6.4e-12 45.8 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA18511.1 - 1e-05 25.6 0.0 4.3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EEA18511.1 - 0.005 16.6 0.8 2.1 8.0 0.1 3.1 3 0 0 3 3 3 2 AAA domain Abhydrolase_6 PF12697.7 EEA18512.1 - 0.00071 20.2 0.9 0.00074 20.2 0.1 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF676 PF05057.14 EEA18512.1 - 0.0017 17.9 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EEA18512.1 - 0.043 13.1 0.0 0.39 10.0 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA18512.1 - 0.045 13.4 0.1 0.12 12.0 0.1 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA18512.1 - 0.049 13.3 0.0 0.086 12.6 0.0 1.5 1 1 0 1 1 1 0 PGAP1-like protein Palm_thioest PF02089.15 EEA18512.1 - 0.086 12.7 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF900 PF05990.12 EEA18512.1 - 0.19 11.2 0.0 0.26 10.8 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) APH PF01636.23 EEA18513.1 - 3.9e-12 46.6 0.0 1.6e-11 44.6 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA18513.1 - 3.2e-06 26.9 0.0 6.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EEA18513.1 - 0.00023 20.2 0.0 0.35 9.7 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.14 EEA18513.1 - 0.00073 18.8 0.0 0.068 12.4 0.0 2.1 2 0 0 2 2 2 2 Fructosamine kinase Pkinase PF00069.25 EEA18513.1 - 0.0017 17.8 0.0 0.99 8.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain EcKinase PF02958.20 EEA18513.1 - 0.0018 17.6 0.0 0.0037 16.6 0.0 1.5 1 1 1 2 2 2 1 Ecdysteroid kinase Pkinase_Tyr PF07714.17 EEA18513.1 - 0.19 11.0 0.0 0.41 9.9 0.0 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase Ank_4 PF13637.6 EEA18514.1 - 0.00021 21.8 0.2 0.049 14.2 0.0 3.1 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA18514.1 - 0.00062 20.3 0.0 0.0066 17.0 0.0 2.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA18514.1 - 0.0075 16.7 0.3 0.43 11.1 0.2 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EEA18514.1 - 0.11 13.1 0.1 2.9 8.8 0.1 2.8 2 0 0 2 2 2 0 Ankyrin repeat RVT_1 PF00078.27 EEA18516.1 - 0.0044 16.5 0.0 0.0093 15.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 EEA18516.1 - 0.0096 16.6 0.1 0.033 14.9 0.1 1.9 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase Pectate_lyase_3 PF12708.7 EEA18517.1 - 2.3e-84 282.6 19.4 1.9e-75 253.4 8.1 2.9 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EEA18517.1 - 0.032 13.9 1.0 0.38 10.5 0.3 2.6 2 0 0 2 2 2 0 N terminal extension of bacteriophage endosialidase zf-RING_UBOX PF13445.6 EEA18519.1 - 7.6e-06 25.9 5.4 7.7e-06 25.8 3.6 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EEA18519.1 - 1.9e-05 24.4 8.7 3e-05 23.8 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA18519.1 - 8.9e-05 22.3 5.4 0.00011 21.9 4.5 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA18519.1 - 0.0034 17.3 9.5 0.007 16.3 9.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA18519.1 - 0.0037 17.1 6.3 0.012 15.4 6.3 1.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 DUF4482 PF14818.6 EEA18519.1 - 0.0042 17.9 4.1 0.0085 17.0 4.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4482) zf-C3HC4_4 PF15227.6 EEA18519.1 - 0.0045 17.1 6.1 0.0069 16.5 5.0 2.0 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EEA18519.1 - 0.0064 16.8 8.7 0.015 15.7 8.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 EEA18519.1 - 0.0085 16.0 1.9 0.015 15.2 1.9 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein KASH_CCD PF14662.6 EEA18519.1 - 0.028 14.2 2.1 0.041 13.7 2.1 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH zf-C3HC4_5 PF17121.5 EEA18519.1 - 0.028 14.3 5.8 0.028 14.3 5.8 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA18519.1 - 0.03 14.1 6.3 0.03 14.1 6.3 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FlxA PF14282.6 EEA18519.1 - 0.031 14.2 1.1 0.051 13.6 1.1 1.3 1 0 0 1 1 1 0 FlxA-like protein LdpA_C PF12617.8 EEA18519.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Iron-Sulfur binding protein C terminal FAD_binding_8 PF08022.12 EEA18522.1 - 2.2e-09 37.3 0.0 6.9e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.12 EEA18522.1 - 1.8e-07 31.4 0.1 3.5e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EEA18522.1 - 6.4e-06 26.3 9.7 6.4e-06 26.3 9.7 3.3 4 0 0 4 4 4 1 Ferric reductase like transmembrane component TEP1_N PF05386.11 EEA18522.1 - 0.061 12.9 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 TEP1 N-terminal domain FtsJ PF01728.19 EEA18523.1 - 0.0013 18.9 0.0 0.0025 18.0 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase zf-CCHC PF00098.23 EEA18524.1 - 0.0006 19.8 1.5 0.0006 19.8 1.5 2.8 2 0 0 2 2 2 1 Zinc knuckle ArfGap PF01412.18 EEA18524.1 - 0.0049 16.9 3.6 0.0049 16.9 3.6 2.4 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf FAM76 PF16046.5 EEA18524.1 - 0.0057 16.0 10.9 0.0057 16.0 10.9 3.0 3 0 0 3 3 3 1 FAM76 protein SlyX PF04102.12 EEA18524.1 - 0.46 11.1 11.9 0.093 13.4 7.2 2.3 2 1 0 2 2 2 0 SlyX PKcGMP_CC PF16808.5 EEA18524.1 - 1.1 9.1 7.5 0.79 9.6 1.7 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase YjcZ PF13990.6 EEA18524.1 - 1.5 8.2 6.4 1.8 7.9 3.4 2.0 2 0 0 2 2 2 0 YjcZ-like protein Exonuc_VII_L PF02601.15 EEA18524.1 - 2.6 7.5 9.7 1.4 8.4 6.0 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4972 PF16342.5 EEA18524.1 - 5.4 6.7 9.6 0.35 10.6 3.1 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4972) SSF PF00474.17 EEA18525.1 - 3.7e-18 65.6 30.9 8e-18 64.5 30.7 1.7 1 1 0 1 1 1 1 Sodium:solute symporter family Bac_luciferase PF00296.20 EEA18526.1 - 1.3e-54 185.8 0.6 1.6e-54 185.4 0.6 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase LysM PF01476.20 EEA18527.1 - 0.0045 17.0 0.0 0.0063 16.6 0.0 1.3 1 0 0 1 1 1 1 LysM domain RT_RNaseH_2 PF17919.1 EEA18528.1 - 1.6e-33 114.7 0.0 3.5e-33 113.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EEA18528.1 - 3.9e-33 113.9 0.0 7.5e-33 113.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EEA18528.1 - 5.5e-30 104.5 0.2 9.6e-30 103.8 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Herpes_IE2_3 PF03361.14 EEA18528.1 - 0.19 11.6 0.0 1.2 8.9 0.0 2.0 2 0 0 2 2 2 0 Herpes virus intermediate/early protein 2/3 zf-CCHC PF00098.23 EEA18529.1 - 0.00014 21.8 0.7 0.00023 21.1 0.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 EEA18529.1 - 0.034 13.9 0.1 0.076 12.8 0.1 1.6 1 0 0 1 1 1 0 Zinc knuckle Cytochrome_C554 PF13435.6 EEA18529.1 - 0.13 13.2 3.6 0.73 10.8 2.7 2.3 1 1 1 2 2 2 0 Cytochrome c554 and c-prime Retrotrans_gag PF03732.17 EEA18530.1 - 0.011 16.0 0.1 0.032 14.5 0.1 1.8 1 0 0 1 1 1 0 Retrotransposon gag protein DDE_Tnp_1_7 PF13843.6 EEA18532.1 - 5.6e-15 55.5 0.1 6.8e-15 55.2 0.1 1.1 1 0 0 1 1 1 1 Transposase IS4 RVT_2 PF07727.14 EEA18533.1 - 3.6e-11 43.2 0.0 6.1e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA18533.1 - 9.8e-07 29.0 0.0 2.3e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Arteri_Gl PF00951.18 EEA18533.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein PAC4 PF16093.5 EEA18534.1 - 0.057 13.6 0.6 0.3 11.3 0.0 2.5 3 0 0 3 3 3 0 Proteasome assembly chaperone 4 DDE_Tnp_1_7 PF13843.6 EEA18535.1 - 8.2e-28 97.7 0.0 1.9e-27 96.5 0.0 1.6 1 1 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA18535.1 - 2.7e-12 47.2 9.4 7.3e-12 45.9 9.4 1.8 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon Asp PF00026.23 EEA18536.1 - 4.5e-53 180.7 0.0 5.3e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA18536.1 - 2.3e-06 28.1 0.0 0.0078 16.8 0.0 2.7 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 EEA18536.1 - 0.0014 18.9 0.0 3.1 8.0 0.0 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Pox_P4B PF03292.14 EEA18536.1 - 0.034 12.4 0.0 0.061 11.6 0.0 1.3 1 0 0 1 1 1 0 Poxvirus P4B major core protein RVT_2 PF07727.14 EEA18537.1 - 2.7e-39 135.3 0.0 4.8e-39 134.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA18537.1 - 3.9e-06 27.0 0.1 1.6e-05 25.0 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EEA18537.1 - 0.00026 20.8 0.1 0.00058 19.7 0.1 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain Asp PF00026.23 EEA18538.1 - 1.4e-55 189.0 0.2 1.6e-55 188.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA18538.1 - 1.9e-05 25.2 0.2 0.0035 18.0 0.0 2.8 2 1 0 2 2 2 1 Aspartyl protease TAXi_N PF14543.6 EEA18538.1 - 8.8e-05 22.8 0.0 0.53 10.5 0.0 3.2 3 1 1 4 4 4 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EEA18538.1 - 0.083 13.5 0.0 3.8 8.1 0.0 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease RVT_2 PF07727.14 EEA18539.1 - 1.3e-29 103.5 0.4 2.6e-29 102.6 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EEA18539.1 - 0.0094 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA18539.1 - 0.02 14.8 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK gag_pre-integrs PF13976.6 EEA18540.1 - 5.1e-07 29.5 0.0 1.3e-06 28.1 0.0 1.7 2 0 0 2 2 2 1 GAG-pre-integrase domain rve PF00665.26 EEA18540.1 - 0.0016 18.7 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Orthopox_F14 PF06076.12 EEA18540.1 - 0.035 14.4 2.1 0.073 13.4 2.1 1.5 1 0 0 1 1 1 0 Orthopoxvirus F14 protein REV1_C PF16727.5 EEA18541.1 - 0.21 12.0 3.2 11 6.5 0.2 2.5 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain WXG100 PF06013.12 EEA18546.1 - 0.023 14.9 0.3 0.69 10.2 0.1 2.1 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DDE_1 PF03184.19 EEA18548.1 - 5e-31 107.7 0.0 7.6e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA18548.1 - 7e-06 26.0 0.0 1.5e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EEA18548.1 - 0.00013 21.7 0.0 0.00053 19.8 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease NmrA PF05368.13 EEA18549.1 - 5.6e-27 94.8 0.6 7.3e-27 94.4 0.6 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA18549.1 - 2.2e-17 63.5 0.1 1.6e-16 60.7 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EEA18549.1 - 0.00043 20.7 0.3 0.00079 19.9 0.1 1.6 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 EEA18549.1 - 0.02 14.3 0.1 0.13 11.7 0.1 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EEA18549.1 - 0.1 12.7 0.7 0.2 11.8 0.1 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DUF4192 PF13830.6 EEA18550.1 - 1.5 8.9 3.4 0.79 9.7 0.6 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4192) COesterase PF00135.28 EEA18551.1 - 3.4e-57 194.5 0.1 8.3e-53 180.0 0.0 2.2 1 1 1 2 2 2 2 Carboxylesterase family Fungal_trans PF04082.18 EEA18551.1 - 1.8e-11 43.6 0.1 2.7e-11 43.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA18551.1 - 4.4e-06 26.7 8.5 1.7e-05 24.9 8.5 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_3 PF07859.13 EEA18551.1 - 5.2e-06 26.5 0.2 2.5e-05 24.3 0.1 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold Tnp_22_trimer PF17489.2 EEA18551.1 - 0.023 14.7 0.8 0.064 13.2 0.8 1.8 1 0 0 1 1 1 0 L1 transposable element trimerization domain Peptidase_S9 PF00326.21 EEA18551.1 - 0.04 13.4 0.0 0.079 12.4 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family XhlA PF10779.9 EEA18551.1 - 0.12 12.6 0.4 0.49 10.6 0.4 2.1 1 0 0 1 1 1 0 Haemolysin XhlA MFS_1 PF07690.16 EEA18552.1 - 5.5e-27 94.6 57.4 1.9e-18 66.6 25.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA18552.1 - 0.0016 17.4 23.1 0.035 12.9 23.0 2.1 1 1 0 1 1 1 1 MFS_1 like family AMP-binding PF00501.28 EEA18553.1 - 2e-29 102.5 0.0 3.2e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EEA18553.1 - 3e-27 95.4 0.0 4.5e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EEA18553.1 - 4.1e-12 46.1 0.0 6.7e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA18553.1 - 0.0012 19.1 0.0 0.003 17.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EEA18553.1 - 0.019 14.0 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 EEA18553.1 - 0.025 14.5 0.0 0.062 13.2 0.0 1.7 1 1 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 EEA18553.1 - 0.051 13.0 0.0 0.13 11.6 0.0 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase VirE1 PF12189.8 EEA18553.1 - 0.46 10.6 1.4 5.7 7.1 0.0 2.7 3 0 0 3 3 3 0 Single-strand DNA-binding protein 2OG-FeII_Oxy PF03171.20 EEA18554.1 - 5.4e-13 49.3 0.0 1.6e-12 47.8 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EEA18554.1 - 0.00033 21.4 0.0 0.00058 20.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DAHP_synth_1 PF00793.20 EEA18555.1 - 3.2e-80 268.9 0.0 4.2e-80 268.5 0.0 1.1 1 0 0 1 1 1 1 DAHP synthetase I family Cu-oxidase_3 PF07732.15 EEA18556.1 - 5.7e-41 139.3 0.1 5.7e-41 139.3 0.1 2.6 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA18556.1 - 4e-37 127.0 9.7 3.3e-30 104.6 2.4 3.7 2 2 1 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EEA18556.1 - 1.1e-24 87.4 0.0 3.3e-24 85.8 0.0 1.9 2 0 0 2 2 2 1 Multicopper oxidase Epimerase PF01370.21 EEA18557.1 - 7.3e-18 64.9 0.0 1.2e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA18557.1 - 7.5e-14 51.4 0.0 1.5e-13 50.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA18557.1 - 7.2e-10 38.8 0.0 1.3e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EEA18557.1 - 9.4e-10 38.1 0.0 2.9e-08 33.2 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EEA18557.1 - 1.1e-08 35.2 0.0 3.4e-08 33.6 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EEA18557.1 - 5.5e-05 22.4 0.0 7.7e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EEA18557.1 - 0.00012 21.6 0.0 0.00026 20.5 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA18557.1 - 0.0011 18.9 0.1 0.0025 17.8 0.1 1.5 1 1 0 1 1 1 1 KR domain F420_oxidored PF03807.17 EEA18557.1 - 0.013 16.0 0.0 0.028 15.0 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Retro_M PF02813.14 EEA18557.1 - 0.026 14.9 0.0 0.05 14.0 0.0 1.4 1 0 0 1 1 1 0 Retroviral M domain adh_short_C2 PF13561.6 EEA18557.1 - 0.033 13.7 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.17 EEA18557.1 - 0.054 12.6 0.0 0.081 12.0 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.13 EEA18557.1 - 0.11 12.1 0.0 0.31 10.6 0.0 1.8 2 0 0 2 2 2 0 NmrA-like family Chorismate_synt PF01264.21 EEA18558.1 - 6.7e-140 465.4 0.0 7.6e-140 465.2 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase FAD_binding_3 PF01494.19 EEA18559.1 - 7.5e-10 38.6 0.0 2.6e-09 36.8 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA18559.1 - 6e-05 22.4 0.8 0.0003 20.1 0.5 1.9 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA18559.1 - 0.0003 21.0 2.1 0.0004 20.6 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA18559.1 - 0.0014 17.4 0.5 0.0031 16.3 0.4 1.6 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EEA18559.1 - 0.0017 18.0 2.0 0.0029 17.2 2.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EEA18559.1 - 0.0018 17.2 0.2 0.046 12.6 0.3 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Thi4 PF01946.17 EEA18559.1 - 0.0024 17.2 0.2 0.0038 16.5 0.2 1.2 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EEA18559.1 - 0.0076 16.3 0.5 0.035 14.1 0.3 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EEA18559.1 - 0.0089 15.3 0.3 0.015 14.6 0.3 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA18559.1 - 0.01 15.1 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EEA18559.1 - 0.016 14.3 0.2 0.11 11.5 0.2 2.0 1 1 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EEA18559.1 - 0.094 11.8 1.1 0.17 10.9 1.1 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EEA18559.1 - 0.1 13.2 0.6 0.37 11.4 0.2 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA18559.1 - 0.35 9.9 0.6 0.5 9.4 0.6 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A EPSP_synthase PF00275.20 EEA18560.1 - 1.1e-122 409.8 0.0 1.6e-122 409.2 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EEA18560.1 - 4.4e-100 334.2 0.1 6.8e-100 333.6 0.1 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EEA18560.1 - 8.8e-57 193.0 0.0 1.8e-56 192.0 0.0 1.6 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EEA18560.1 - 7.4e-39 133.4 0.0 9.4e-37 126.6 0.0 2.7 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 EEA18560.1 - 2.4e-23 82.2 0.0 7.2e-23 80.6 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EEA18560.1 - 8.2e-09 35.1 0.3 3e-08 33.3 0.1 2.1 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 EEA18560.1 - 2.1e-08 34.2 0.0 6.2e-08 32.7 0.0 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.20 EEA18560.1 - 6.9e-05 22.9 0.0 0.0002 21.4 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_16 PF13191.6 EEA18560.1 - 0.0072 16.7 1.0 1.9 8.8 0.0 3.9 5 0 0 5 5 4 1 AAA ATPase domain AAA_18 PF13238.6 EEA18560.1 - 0.013 16.0 0.0 0.041 14.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA18560.1 - 0.043 14.1 0.0 0.25 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EEA18560.1 - 0.049 13.7 0.0 0.22 11.6 0.0 2.1 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 EEA18560.1 - 0.052 13.3 0.1 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Sacchrp_dh_NADP PF03435.18 EEA18560.1 - 0.054 13.8 0.0 0.3 11.3 0.0 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DDE_Tnp_1_7 PF13843.6 EEA18561.1 - 5.2e-58 197.0 0.3 1e-57 196.1 0.3 1.5 1 1 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA18561.1 - 6.8e-12 46.0 9.4 1.5e-11 44.9 9.4 1.7 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon F-box_4 PF15966.5 EEA18563.1 - 0.00022 21.1 0.8 0.00048 20.0 0.1 1.9 2 0 0 2 2 2 1 F-box F-box PF00646.33 EEA18563.1 - 0.0061 16.4 2.3 0.02 14.8 0.2 3.0 3 0 0 3 3 3 1 F-box domain GFA PF04828.14 EEA18564.1 - 6.1e-13 48.9 14.3 2.6e-08 34.1 2.8 2.7 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme RVT_2 PF07727.14 EEA18565.1 - 2.1e-38 132.3 0.2 3.5e-38 131.6 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EEA18565.1 - 0.017 14.7 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Orthopox_F14 PF06076.12 EEA18565.1 - 0.053 13.8 2.8 0.15 12.4 2.8 1.8 1 0 0 1 1 1 0 Orthopoxvirus F14 protein Flg_hook PF02120.16 EEA18565.1 - 0.054 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK gag_pre-integrs PF13976.6 EEA18566.1 - 1e-05 25.3 1.3 2.5e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 GAG-pre-integrase domain REV1_C PF16727.5 EEA18566.1 - 0.27 11.7 4.0 6.3 7.3 0.3 2.6 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA18566.1 - 4.7 7.0 5.8 1 9.1 0.2 2.5 3 0 0 3 3 3 0 Sulfotransferase domain Helicase_C PF00271.31 EEA18567.1 - 2.1e-13 50.6 0.0 4.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA18567.1 - 3.5e-11 43.2 1.1 3.8e-05 23.5 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 EEA18567.1 - 0.00024 21.1 0.2 0.42 10.6 0.0 2.7 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA18567.1 - 0.016 14.5 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CTU2 PF10288.9 EEA18567.1 - 0.051 13.8 1.8 0.71 10.1 0.0 2.8 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 TK PF00265.18 EEA18567.1 - 0.078 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Thymidine kinase AF-4 PF05110.13 EEA18567.1 - 1.9 6.5 25.5 2.5 6.1 25.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein OrsD PF12013.8 EEA18568.1 - 8.9e-20 71.2 0.0 2.4e-19 69.9 0.0 1.8 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D HsbA PF12296.8 EEA18569.1 - 3.9e-17 62.8 0.0 7.8e-17 61.8 0.0 1.4 2 0 0 2 2 2 1 Hydrophobic surface binding protein A gag_pre-integrs PF13976.6 EEA18570.1 - 5.3e-07 29.4 0.0 1.2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA18570.1 - 1.4e-05 25.3 0.2 3.2e-05 24.1 0.2 1.6 1 0 0 1 1 1 1 Integrase core domain QIL1 PF15884.5 EEA18570.1 - 0.078 13.6 0.0 0.89 10.2 0.0 2.4 2 0 0 2 2 2 0 MICOS complex subunit MIC13, QIL1 GXWXG PF14231.6 EEA18570.1 - 0.12 12.5 0.1 0.26 11.4 0.1 1.5 1 0 0 1 1 1 0 GXWXG protein RVT_2 PF07727.14 EEA18571.1 - 4.1e-09 36.4 0.0 5.8e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FrhB_FdhB_C PF04432.13 EEA18571.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus RVT_2 PF07727.14 EEA18572.1 - 1.7e-06 27.9 0.1 2.6e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA18572.1 - 0.03 14.2 0.0 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Pro_CA PF00484.19 EEA18573.1 - 3.5e-09 37.1 0.2 1.4e-08 35.2 0.2 1.9 1 1 0 1 1 1 1 Carbonic anhydrase FAD_binding_3 PF01494.19 EEA18574.1 - 1.8e-24 86.7 0.0 2.5e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EEA18574.1 - 3.4e-06 26.5 0.3 8.2e-06 25.3 0.2 1.7 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA18574.1 - 0.00015 21.1 3.9 0.0077 15.5 1.4 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA18574.1 - 0.0002 21.5 1.1 0.00064 19.9 1.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA18574.1 - 0.00031 20.4 0.0 0.00047 19.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA18574.1 - 0.00039 19.6 3.6 0.00039 19.6 3.6 1.7 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EEA18574.1 - 0.062 12.5 0.3 0.11 11.7 0.3 1.3 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 EEA18574.1 - 0.084 12.2 2.6 0.12 11.6 2.6 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EEA18574.1 - 0.087 11.8 1.0 0.69 8.9 1.0 2.0 1 1 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 EEA18574.1 - 0.13 10.9 0.9 0.26 10.0 0.9 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EEA18574.1 - 0.13 12.8 3.5 0.27 11.8 1.3 2.4 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase CH_2 PF06294.11 EEA18574.1 - 0.15 12.2 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 CH-like domain in sperm protein GIDA PF01134.22 EEA18574.1 - 0.43 9.6 4.5 0.43 9.6 3.2 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF3237 PF11578.8 EEA18575.1 - 6.9e-29 100.6 0.1 7.7e-29 100.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) adh_short_C2 PF13561.6 EEA18576.1 - 5.5e-52 176.6 0.6 8.9e-52 176.0 0.6 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA18576.1 - 2.4e-48 164.2 0.2 3.9e-48 163.5 0.2 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA18576.1 - 1.6e-07 31.5 0.2 3e-07 30.5 0.2 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA18576.1 - 1.7e-05 24.4 0.1 0.08 12.4 0.0 3.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family Pyr_redox_3 PF13738.6 EEA18577.1 - 3.2e-15 56.2 0.0 1.8e-14 53.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EEA18577.1 - 4e-14 51.9 0.0 5.9e-06 25.0 0.0 3.2 3 1 0 3 3 3 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EEA18577.1 - 1.2e-07 31.2 0.0 1.1e-06 28.1 0.0 2.4 4 0 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EEA18577.1 - 1e-05 24.9 0.0 9.8e-05 21.7 0.0 2.1 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EEA18577.1 - 1.2e-05 25.5 0.0 2.9e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA18577.1 - 0.00017 20.9 0.0 0.00089 18.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA18577.1 - 0.00026 21.0 0.1 0.054 13.5 0.1 3.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EEA18577.1 - 0.00065 20.2 0.2 15 6.3 0.0 3.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase ketoacyl-synt PF00109.26 EEA18579.1 - 2.3e-70 237.1 0.0 3.9e-70 236.3 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EEA18579.1 - 3e-60 204.0 0.1 4.8e-60 203.3 0.1 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EEA18579.1 - 8.8e-57 191.9 0.1 7e-56 189.0 0.0 2.5 3 0 0 3 3 3 1 KR domain Acyl_transf_1 PF00698.21 EEA18579.1 - 4.9e-51 174.1 0.0 1e-50 173.1 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA18579.1 - 1.5e-34 118.5 0.2 5.9e-34 116.6 0.4 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EEA18579.1 - 1.3e-18 67.5 0.0 4.2e-18 65.8 0.0 1.9 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EEA18579.1 - 3.9e-08 33.0 0.1 9.1e-08 31.8 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Thiolase_N PF00108.23 EEA18579.1 - 8e-06 25.4 0.1 7.9e-05 22.1 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain PP-binding PF00550.25 EEA18579.1 - 0.011 16.0 0.0 0.03 14.7 0.0 1.8 1 0 0 1 1 1 0 Phosphopantetheine attachment site MFS_1 PF07690.16 EEA18580.1 - 5.5e-30 104.5 49.4 1.5e-29 103.0 44.6 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA18580.1 - 4.5e-11 42.3 13.0 4.5e-11 42.3 13.0 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter Zn_clus PF00172.18 EEA18581.1 - 0.00039 20.5 8.2 0.0013 18.8 8.2 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_jaz PF12171.8 EEA18581.1 - 0.052 13.9 0.3 0.11 12.8 0.3 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Fungal_trans PF04082.18 EEA18582.1 - 8.5e-16 57.8 0.0 1.6e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain KNTase_C PF07827.11 EEA18582.1 - 0.054 13.3 0.1 5.6 6.8 0.0 2.7 2 1 1 3 3 3 0 KNTase C-terminal domain HTH_Tnp_Tc5 PF03221.16 EEA18583.1 - 5.2e-10 39.2 0.4 1.4e-09 37.8 0.4 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Spore_YpjB PF09577.10 EEA18583.1 - 1.3 8.8 13.7 2.1 8.1 13.7 1.3 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) RR_TM4-6 PF06459.12 EEA18583.1 - 4.5 7.0 15.8 7 6.4 15.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Glyco_hydro_7 PF00840.20 EEA18584.1 - 2.5e-143 477.9 13.4 2.5e-143 477.9 13.4 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 7 CBM_1 PF00734.18 EEA18584.1 - 1.6e-12 47.1 12.0 1.6e-12 47.1 12.0 4.8 4 0 0 4 4 4 1 Fungal cellulose binding domain IF-2B PF01008.17 EEA18587.1 - 5.7e-18 65.1 0.0 5.3e-17 61.9 0.0 2.1 2 1 0 2 2 2 1 Initiation factor 2 subunit family NUDIX PF00293.28 EEA18587.1 - 4.8e-07 29.9 0.0 1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain rve PF00665.26 EEA18591.1 - 1.8e-05 24.9 0.0 7.9e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Clr5 PF14420.6 EEA18591.1 - 0.00072 19.7 0.2 0.015 15.6 0.0 2.8 2 0 0 2 2 2 1 Clr5 domain HTH_Tnp_Tc3_2 PF01498.18 EEA18591.1 - 0.0021 18.2 3.1 0.077 13.3 0.3 2.5 2 0 0 2 2 2 1 Transposase Arg_repressor PF01316.21 EEA18591.1 - 0.015 15.1 0.9 0.12 12.1 0.3 2.8 1 1 1 2 2 2 0 Arginine repressor, DNA binding domain HTH_33 PF13592.6 EEA18591.1 - 0.051 13.2 0.5 0.44 10.2 0.1 2.4 2 0 0 2 2 2 0 Winged helix-turn helix HMMR_N PF15905.5 EEA18591.1 - 0.078 12.4 1.2 0.14 11.6 1.2 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal HU-DNA_bdg PF14848.6 EEA18591.1 - 0.17 11.9 0.2 7.7 6.5 0.1 2.8 2 1 1 3 3 3 0 DNA-binding domain Mur_ligase PF01225.25 EEA18592.1 - 0.054 13.8 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Mur ligase family, catalytic domain Histone PF00125.24 EEA18593.1 - 1.3e-35 122.6 0.4 1.6e-35 122.3 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EEA18593.1 - 0.00058 20.0 0.2 0.00086 19.4 0.2 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EEA18593.1 - 0.0058 17.0 0.6 0.0095 16.3 0.6 1.3 1 0 0 1 1 1 1 CENP-S protein Aminotran_4 PF01063.19 EEA18594.1 - 1.3e-25 90.6 0.0 1.6e-25 90.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Ribosomal_L9_C PF03948.14 EEA18594.1 - 0.1 13.1 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L9, C-terminal domain Ribonuc_2-5A PF06479.12 EEA18595.1 - 1.3e-39 135.3 0.1 2.4e-39 134.4 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 EEA18595.1 - 3.7e-39 134.7 0.0 3.7e-28 98.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA18595.1 - 7.3e-20 71.3 0.0 9.3e-19 67.7 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 EEA18595.1 - 3.2e-05 23.6 0.0 0.12 12.3 0.0 3.0 2 0 0 2 2 2 2 PQQ enzyme repeat PQQ_2 PF13360.6 EEA18595.1 - 0.0048 16.5 0.1 0.027 14.1 0.1 2.1 1 1 1 2 2 2 1 PQQ-like domain Kdo PF06293.14 EEA18595.1 - 0.012 15.0 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA18595.1 - 0.048 12.4 0.0 0.11 11.2 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase Pcc1 PF09341.10 EEA18595.1 - 0.16 12.1 0.0 0.44 10.7 0.0 1.7 1 0 0 1 1 1 0 Transcription factor Pcc1 ELYS PF13934.6 EEA18597.1 - 5.8e-64 216.1 2.2 7.1e-64 215.8 2.2 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly SMC_N PF02463.19 EEA18598.1 - 1.2e-63 214.5 47.0 8.7e-63 211.7 47.0 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA18598.1 - 4e-25 88.4 0.1 2.5e-24 85.8 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EEA18598.1 - 3.1e-11 43.6 4.5 5e-05 23.2 0.0 3.6 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EEA18598.1 - 2.2e-07 30.9 6.3 2.2e-07 30.9 6.3 4.4 3 2 1 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 EEA18598.1 - 7.3e-05 22.4 0.0 0.0019 17.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Tropomyosin_1 PF12718.7 EEA18598.1 - 0.0003 21.0 5.5 0.0003 21.0 5.5 7.8 4 2 4 8 8 8 3 Tropomyosin like AAA_13 PF13166.6 EEA18598.1 - 0.00069 18.4 30.6 0.00069 18.4 30.6 6.0 4 2 3 7 7 7 3 AAA domain Ribosomal_S10 PF00338.22 EEA18599.1 - 2.3e-26 91.9 0.5 2.7e-26 91.6 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e CUE PF02845.16 EEA18600.1 - 9.7e-09 34.8 0.0 2.3e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 CUE domain Mso1_Sec1_bdg PF14475.6 EEA18600.1 - 0.01 15.4 0.2 0.15 11.7 0.0 2.5 2 0 0 2 2 2 0 Sec1-binding region of Mso1 ORC5_C PF14630.6 EEA18600.1 - 3.8 6.9 6.1 1.5 8.2 0.8 2.5 2 1 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus Glyco_hydro_92 PF07971.12 EEA18601.1 - 2.8e-108 362.8 1.4 4e-108 362.3 1.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 DNA_binding_1 PF01035.20 EEA18601.1 - 1.9e-24 85.6 0.0 3.5e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain zf-C2H2 PF00096.26 EEA18602.1 - 1.3e-05 25.4 7.3 0.0018 18.6 0.4 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA18602.1 - 0.0018 18.9 3.7 0.015 16.1 0.5 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EEA18602.1 - 0.019 15.0 0.5 0.039 14.1 0.5 1.4 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 EEA18602.1 - 0.08 13.0 4.2 0.092 12.8 0.5 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.15 EEA18602.1 - 0.35 10.9 2.8 7.3 6.7 0.2 2.4 2 0 0 2 2 2 0 BED zinc finger RRN9 PF10680.9 EEA18603.1 - 0.007 16.6 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor Transp_cyt_pur PF02133.15 EEA18604.1 - 1.5e-20 73.5 36.6 3e-20 72.4 36.6 1.5 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin LptF_LptG PF03739.14 EEA18604.1 - 0.014 14.2 15.5 0.42 9.4 0.7 3.2 3 0 0 3 3 3 0 Lipopolysaccharide export system permease LptF/LptG UPF0139 PF03669.13 EEA18604.1 - 0.075 12.9 0.2 0.3 11.0 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) Peptidase_S28 PF05577.12 EEA18605.1 - 5.8e-40 137.4 4.5 6.1e-30 104.4 0.1 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 ATP_bind_2 PF03668.15 EEA18606.1 - 0.0034 16.7 0.1 0.12 11.6 0.0 2.1 2 0 0 2 2 2 1 P-loop ATPase protein family DUF1948 PF09185.10 EEA18606.1 - 0.0085 16.0 0.1 0.015 15.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1948) DUF5097 PF17020.5 EEA18606.1 - 0.045 14.1 0.1 0.069 13.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) DnaI_N PF07319.11 EEA18606.1 - 0.052 14.2 0.1 0.1 13.3 0.1 1.5 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus GldM_C PF12080.8 EEA18606.1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 GldM C-terminal domain Fungal_trans_2 PF11951.8 EEA18607.1 - 4.3e-11 42.2 0.5 4.1e-10 39.0 0.1 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA18607.1 - 9.1e-08 32.1 11.0 2e-07 31.0 11.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SIR2_2 PF13289.6 EEA18607.1 - 0.011 15.9 0.0 0.4 10.8 0.0 2.3 2 0 0 2 2 2 0 SIR2-like domain ADH_N PF08240.12 EEA18608.1 - 4.5e-28 97.3 1.4 9.2e-28 96.3 1.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA18608.1 - 3e-10 40.2 0.0 7.4e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA18608.1 - 0.029 13.8 0.0 0.056 12.8 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pectate_lyase_3 PF12708.7 EEA18609.1 - 9e-91 303.5 17.7 8.7e-82 274.1 5.9 2.9 4 0 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EEA18609.1 - 5.8e-07 29.1 1.3 0.031 14.0 0.1 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase DDE_2 PF02914.15 EEA18612.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Mu transposase MFS_1 PF07690.16 EEA18614.1 - 9.2e-36 123.5 36.6 9.2e-36 123.5 36.6 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA18614.1 - 5.4e-12 44.9 10.0 7.6e-12 44.4 10.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EEA18614.1 - 0.0031 16.4 4.3 0.0031 16.4 4.3 2.5 2 2 1 3 3 3 1 MFS_1 like family OATP PF03137.20 EEA18614.1 - 0.0081 14.5 0.5 0.0081 14.5 0.5 2.0 2 2 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family PA PF02225.22 EEA18614.1 - 0.1 12.6 0.0 6.2 6.9 0.0 2.4 2 0 0 2 2 2 0 PA domain Glyco_tranf_2_3 PF13641.6 EEA18615.1 - 1.4e-16 61.1 0.0 2e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EEA18615.1 - 3.3e-05 23.4 0.0 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EEA18615.1 - 0.00072 19.4 0.0 0.0018 18.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 adh_short_C2 PF13561.6 EEA18616.1 - 1.5e-53 181.8 0.1 2e-53 181.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA18616.1 - 1.2e-44 152.1 0.0 1.8e-44 151.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase T5orf172 PF10544.9 EEA18616.1 - 1e-15 58.1 0.4 3.6e-15 56.3 0.4 2.0 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 EEA18616.1 - 3.4e-10 40.5 0.2 9.4e-10 39.0 0.2 1.8 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 KR PF08659.10 EEA18616.1 - 3.4e-05 23.8 0.0 6.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EEA18616.1 - 0.00014 21.3 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EEA18616.1 - 0.00026 20.6 0.1 0.00053 19.5 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EEA18616.1 - 0.00032 20.1 0.0 0.00056 19.4 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_N PF08240.12 EEA18617.1 - 7.3e-29 99.8 0.3 1.3e-28 99.0 0.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA18617.1 - 5.9e-24 84.5 1.1 9.6e-24 83.8 1.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA18617.1 - 4.4e-07 31.0 0.1 7.3e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA18617.1 - 0.0097 15.3 0.3 0.017 14.5 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EEA18617.1 - 0.025 13.9 1.1 0.041 13.2 1.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain bZIP_1 PF00170.21 EEA18618.1 - 0.023 14.8 6.3 0.049 13.7 6.3 1.4 1 0 0 1 1 1 0 bZIP transcription factor AcetylCoA_hydro PF02550.15 EEA18619.1 - 2.3e-50 171.3 0.0 3.5e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EEA18619.1 - 2.3e-43 147.8 0.0 3.4e-43 147.2 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Ank_2 PF12796.7 EEA18620.1 - 8e-21 74.4 0.2 1.5e-06 28.7 0.0 5.9 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA18620.1 - 2.2e-19 67.5 4.2 0.052 14.1 0.0 10.1 10 0 0 10 10 10 3 Ankyrin repeat Ank_4 PF13637.6 EEA18620.1 - 2.2e-17 63.2 2.2 0.011 16.3 0.0 7.8 4 2 4 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EEA18620.1 - 8.9e-14 51.2 4.0 0.041 14.3 0.0 8.7 8 2 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EEA18620.1 - 1.2e-09 38.2 3.2 0.0044 17.3 0.0 6.5 5 2 2 7 7 7 3 Ankyrin repeats (many copies) F-box-like PF12937.7 EEA18620.1 - 0.0012 18.7 0.8 0.003 17.4 0.8 1.7 1 0 0 1 1 1 1 F-box-like Sin3a_C PF16879.5 EEA18621.1 - 4.4e-80 269.5 8.6 4.4e-80 269.5 8.6 2.8 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 EEA18621.1 - 6.4e-47 157.5 2.4 1.1e-17 63.8 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EEA18621.1 - 1.2e-38 131.1 0.1 3.9e-38 129.5 0.1 2.0 1 0 0 1 1 1 1 Sin3 family co-repressor TSP_NTD PF17804.1 EEA18621.1 - 0.012 15.9 1.6 0.012 15.9 1.6 3.4 3 1 0 3 3 3 0 Tail specific protease N-terminal domain WD40 PF00400.32 EEA18622.1 - 6e-13 49.1 3.0 0.12 13.3 0.3 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18622.1 - 0.01 16.1 0.2 2.9 8.2 0.0 3.7 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA18623.1 - 1.3e-12 48.0 3.0 0.14 13.1 0.3 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18623.1 - 0.0099 16.2 0.2 3.3 8.1 0.0 3.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Cactin_mid PF10312.9 EEA18624.1 - 0.056 13.2 1.5 0.093 12.4 1.5 1.3 1 0 0 1 1 1 0 Conserved mid region of cactin FAD_binding_2 PF00890.24 EEA18625.1 - 1.2e-83 281.5 0.2 1.5e-83 281.2 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EEA18625.1 - 3.7e-22 78.3 0.1 3.2e-20 72.0 0.0 3.2 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EEA18625.1 - 1.8e-13 50.8 0.1 3.3e-13 50.0 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EEA18625.1 - 2.7e-09 36.9 1.7 1.2e-08 34.8 1.7 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA18625.1 - 3.9e-08 33.4 1.8 1e-07 32.0 0.2 2.5 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA18625.1 - 8e-08 31.9 0.2 7.9e-07 28.6 0.2 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA18625.1 - 1.1e-06 28.2 0.1 0.013 14.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA18625.1 - 2.1e-06 26.7 4.1 8.6e-05 21.4 1.4 3.0 2 1 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 EEA18625.1 - 0.00012 21.4 0.1 0.00021 20.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EEA18625.1 - 0.00019 20.8 0.6 0.03 13.6 0.1 2.3 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 EEA18625.1 - 0.00051 19.2 2.3 0.18 10.9 0.5 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Amino_oxidase PF01593.24 EEA18625.1 - 0.0057 16.0 1.4 2 7.6 0.0 3.0 2 1 1 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EEA18625.1 - 0.0074 16.3 2.0 0.18 11.8 2.0 2.6 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EEA18625.1 - 0.021 15.4 2.4 5.2 7.7 0.2 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EEA18625.1 - 0.054 12.8 0.2 0.11 11.8 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PCI PF01399.27 EEA18626.1 - 5.7e-12 46.1 0.0 1.4e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 EEA18626.1 - 1.7e-05 24.6 0.1 3.9e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_8 PF13181.6 EEA18626.1 - 0.087 13.1 0.6 0.77 10.1 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat FAM47 PF14642.6 EEA18626.1 - 0.2 11.2 0.1 0.36 10.3 0.1 1.3 1 0 0 1 1 1 0 FAM47 family TPR_19 PF14559.6 EEA18626.1 - 0.6 10.7 5.7 7.2 7.2 0.2 3.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TFIIF_beta_N PF17683.1 EEA18627.1 - 1.4e-32 113.2 0.4 2.8e-32 112.2 0.4 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 EEA18627.1 - 1.5e-25 89.1 0.3 3.1e-25 88.1 0.3 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 EEA18627.1 - 0.0061 17.4 1.7 0.032 15.0 1.7 2.0 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain zf-CCCH PF00642.24 EEA18628.1 - 3.6e-12 45.9 27.6 5.7e-06 26.1 1.4 5.4 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EEA18628.1 - 3.1e-08 33.4 30.5 0.0051 16.8 1.5 5.9 5 1 0 5 5 5 4 Zinc finger domain zf-CCCH_3 PF15663.5 EEA18628.1 - 4.8e-05 23.5 1.1 4.8e-05 23.5 1.1 3.5 1 1 2 3 3 3 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 EEA18628.1 - 0.0006 19.6 0.1 0.0006 19.6 0.1 5.1 5 1 0 5 5 5 2 CCCH-type zinc finger Torus PF16131.5 EEA18628.1 - 0.024 15.3 24.6 0.031 15.0 0.4 5.0 2 1 3 5 5 5 0 Torus domain zf-CCCH_2 PF14608.6 EEA18628.1 - 0.041 14.4 31.8 0.083 13.4 1.9 4.8 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger zf-C3H1 PF10650.9 EEA18628.1 - 0.29 10.9 12.4 0.39 10.5 0.0 4.6 5 0 0 5 5 5 0 Putative zinc-finger domain bZIP_1 PF00170.21 EEA18629.1 - 5.4e-08 32.8 8.9 5.4e-08 32.8 8.9 2.6 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EEA18629.1 - 2.4e-06 27.5 5.7 2.4e-06 27.5 5.7 2.7 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 EEA18629.1 - 2.2e-05 24.9 10.7 2.2e-05 24.9 10.7 3.6 2 1 2 4 4 4 1 bZIP Maf transcription factor DUF4854 PF16146.5 EEA18629.1 - 0.064 13.6 3.7 3.2 8.1 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4854) RCC1 PF00415.18 EEA18630.1 - 8e-56 186.5 2.4 4.4e-12 46.4 0.1 7.4 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA18630.1 - 8.6e-43 143.3 21.1 6.9e-11 41.7 0.7 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Presenilin PF01080.17 EEA18630.1 - 7.4 5.2 5.2 10 4.8 5.2 1.1 1 0 0 1 1 1 0 Presenilin FmdA_AmdA PF03069.15 EEA18631.1 - 4.2e-174 578.7 0.0 4.8e-174 578.5 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family Sel1 PF08238.12 EEA18632.1 - 9.7e-14 51.5 6.1 3.1e-05 24.5 0.1 3.7 3 0 0 3 3 3 3 Sel1 repeat NUDE_C PF04880.13 EEA18632.1 - 0.62 10.5 8.3 1.2 9.6 8.3 1.4 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF908 PF06012.12 EEA18632.1 - 1 8.7 4.7 1.7 8.0 4.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Mt_ATP-synt_B PF05405.14 EEA18633.1 - 1.3e-52 177.7 5.4 1.7e-52 177.3 5.4 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Virul_Fac PF10139.9 EEA18633.1 - 0.008 14.5 2.7 0.0098 14.2 2.7 1.1 1 0 0 1 1 1 1 Putative bacterial virulence factor DUF1539 PF07560.11 EEA18633.1 - 0.042 13.9 0.5 0.077 13.1 0.5 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) CBF PF03914.17 EEA18634.1 - 2.8e-38 131.6 1.1 6.8e-38 130.4 1.1 1.7 1 0 0 1 1 1 1 CBF/Mak21 family ATP11 PF06644.11 EEA18634.1 - 3.5 7.3 6.8 7.3 6.3 6.8 1.5 1 0 0 1 1 1 0 ATP11 protein GPI-anchored PF10342.9 EEA18635.1 - 1.5e-11 44.9 0.0 1.5e-11 44.9 0.0 2.9 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF3301 PF11743.8 EEA18635.1 - 0.0011 18.6 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3301) SHE3 PF17078.5 EEA18636.1 - 7.8e-05 22.5 28.3 0.05 13.3 19.3 2.2 1 1 1 2 2 2 2 SWI5-dependent HO expression protein 3 TolA_bind_tri PF16331.5 EEA18636.1 - 0.021 14.9 1.6 0.021 14.9 1.6 3.5 3 1 1 4 4 4 0 TolA binding protein trimerisation Jnk-SapK_ap_N PF09744.9 EEA18636.1 - 0.04 14.1 31.4 0.61 10.3 17.5 2.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 ZapB PF06005.12 EEA18636.1 - 0.04 14.4 4.0 0.04 14.4 4.0 4.2 2 1 0 2 2 2 0 Cell division protein ZapB Spc7 PF08317.11 EEA18636.1 - 0.062 12.2 35.1 0.098 11.5 15.0 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Vip3A_N PF12495.8 EEA18636.1 - 0.16 11.8 0.4 0.39 10.6 0.1 1.7 2 0 0 2 2 2 0 Vegetative insecticide protein 3A N terminal FlxA PF14282.6 EEA18636.1 - 0.52 10.3 25.9 0.042 13.8 4.8 3.5 2 1 2 4 4 4 0 FlxA-like protein HrpB7 PF09486.10 EEA18636.1 - 2.5 8.5 31.1 12 6.3 20.6 3.4 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) ADIP PF11559.8 EEA18636.1 - 3.2 7.8 36.6 0.87 9.7 12.4 3.3 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Lebercilin PF15619.6 EEA18636.1 - 5.9 6.5 39.5 6.9 6.3 12.1 2.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Hid1 PF12722.7 EEA18637.1 - 1.2 7.2 4.7 1.6 6.7 4.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MMS19_C PF12460.8 EEA18638.1 - 8.7e-124 413.9 24.0 2.6e-123 412.3 15.2 3.6 3 1 0 4 4 4 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EEA18638.1 - 6.2e-94 314.4 2.6 4.9e-93 311.5 0.1 3.1 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II 7TMR-HDED PF07697.11 EEA18638.1 - 0.013 15.7 0.0 0.18 11.9 0.0 2.8 2 2 0 2 2 2 0 7TM-HD extracellular HEAT_2 PF13646.6 EEA18638.1 - 0.021 15.2 9.2 6.3 7.3 0.1 6.2 6 0 0 6 6 6 0 HEAT repeats Cnd1 PF12717.7 EEA18638.1 - 0.082 12.9 3.9 0.23 11.5 0.1 3.5 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF1912 PF08930.10 EEA18638.1 - 0.13 12.4 0.0 18 5.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1912) CLASP_N PF12348.8 EEA18638.1 - 0.24 10.9 2.1 18 4.8 0.1 3.6 3 1 0 3 3 3 0 CLASP N terminal DegS PF05384.11 EEA18638.1 - 0.4 10.2 2.1 1.9 8.0 0.1 2.5 2 0 0 2 2 2 0 Sensor protein DegS HEAT PF02985.22 EEA18638.1 - 0.56 10.6 11.5 17 6.0 0.1 6.1 7 0 0 7 7 7 0 HEAT repeat HEAT_EZ PF13513.6 EEA18638.1 - 2.8 8.6 16.4 25 5.5 0.3 6.4 6 1 0 6 6 6 0 HEAT-like repeat Fasciclin PF02469.22 EEA18639.1 - 2.8e-05 24.4 0.0 4.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain EMC3_TMCO1 PF01956.16 EEA18640.1 - 4.5e-53 179.5 0.5 5.9e-53 179.1 0.5 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like SPC25 PF06703.11 EEA18641.1 - 3.9e-48 163.3 0.1 4.6e-48 163.1 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) SCAB-Ig PF16709.5 EEA18641.1 - 0.056 13.5 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Ig domain of plant-specific actin-binding protein THF_DHG_CYH PF00763.23 EEA18642.1 - 2.6e-26 92.2 0.0 3.8e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EEA18642.1 - 1e-12 47.6 0.3 2.3e-09 36.8 0.0 2.6 2 2 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ATP-synt_ab PF00006.25 EEA18643.1 - 2.7e-72 242.9 0.0 4e-72 242.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EEA18643.1 - 2.2e-49 167.0 0.7 3.8e-49 166.2 0.7 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EEA18643.1 - 2.7e-15 56.6 3.4 7.1e-15 55.3 3.4 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab PF00006.25 EEA18644.1 - 2.7e-72 242.9 0.0 4e-72 242.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EEA18644.1 - 2.2e-49 167.0 0.7 3.8e-49 166.2 0.7 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EEA18644.1 - 2.7e-15 56.6 3.4 7.1e-15 55.3 3.4 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Zn_clus PF00172.18 EEA18645.1 - 5e-06 26.5 9.0 1e-05 25.5 9.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA18646.1 - 1.3e-41 142.7 42.3 1.9e-38 132.3 24.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA18646.1 - 1.4e-09 37.3 13.6 1.4e-09 37.3 13.6 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter Wzz PF02706.15 EEA18646.1 - 2.5 8.5 5.7 29 5.1 0.4 3.6 3 0 0 3 3 3 0 Chain length determinant protein Tad PF13400.6 EEA18646.1 - 7.6 6.9 0.0 7.6 6.9 0.0 4.9 7 0 0 7 7 7 0 Putative Flp pilus-assembly TadE/G-like FAD_binding_4 PF01565.23 EEA18648.1 - 4.1e-15 55.7 2.6 7.2e-15 54.9 2.6 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA18648.1 - 1.5e-09 37.8 0.1 1.5e-09 37.8 0.1 2.0 2 0 0 2 2 2 1 Berberine and berberine like FAD_binding_4 PF01565.23 EEA18649.1 - 1.3e-27 96.3 0.9 2.3e-27 95.5 0.9 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA18649.1 - 0.0025 17.9 0.0 0.0054 16.8 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like ketoacyl-synt PF00109.26 EEA18650.1 - 1.7e-66 224.4 3.4 2.9e-66 223.6 0.1 2.7 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA18650.1 - 4.9e-62 209.0 0.2 1.6e-61 207.4 0.1 2.0 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EEA18650.1 - 4.5e-45 154.5 0.0 7.5e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EEA18650.1 - 4.7e-38 131.1 0.0 8e-38 130.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EEA18650.1 - 9.8e-33 112.7 0.7 2.1e-32 111.6 0.7 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 EEA18650.1 - 1.2e-20 74.9 0.0 2.9e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EEA18650.1 - 7.8e-19 67.9 0.1 5e-18 65.3 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EEA18650.1 - 7.8e-15 55.3 0.1 2.4e-09 37.7 0.0 2.9 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EEA18650.1 - 3.3e-09 37.0 0.1 8.1e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 EEA18650.1 - 3.5e-08 33.1 0.1 1.3e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase ADH_N PF08240.12 EEA18650.1 - 2.5e-06 27.3 0.2 9.1e-06 25.5 0.2 2.0 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EEA18650.1 - 0.0014 18.1 0.2 0.059 12.7 0.0 2.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain SAT PF16073.5 EEA18650.1 - 0.11 12.2 0.0 4 7.1 0.0 2.5 1 1 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis AATase PF07247.12 EEA18651.1 - 2.2e-10 39.7 0.0 3.1e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 Alcohol acetyltransferase ketoacyl-synt PF00109.26 EEA18652.1 - 3.6e-73 246.3 0.0 1.2e-72 244.6 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA18652.1 - 9.3e-52 175.5 0.1 4.8e-50 170.0 0.1 2.7 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EEA18652.1 - 2.1e-43 148.7 0.1 4.3e-43 147.6 0.1 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EEA18652.1 - 3e-42 145.3 0.1 5.3e-42 144.4 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain NAD_binding_4 PF07993.12 EEA18652.1 - 4.7e-29 101.3 0.0 8.4e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 EEA18652.1 - 2.3e-28 98.6 0.0 5.5e-28 97.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EEA18652.1 - 1.5e-19 70.6 0.0 5.1e-19 68.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EEA18652.1 - 3e-14 53.4 0.0 1.2e-13 51.5 0.0 2.1 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 EEA18652.1 - 8.2e-14 51.8 0.0 7.6e-13 48.6 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 EEA18652.1 - 9e-14 51.4 0.0 1.3e-12 47.6 0.2 2.7 3 0 0 3 3 3 1 short chain dehydrogenase Methyltransf_25 PF13649.6 EEA18652.1 - 8.3e-13 48.9 0.0 4e-12 46.7 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA18652.1 - 1.8e-11 44.6 0.0 9.2e-11 42.2 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Epimerase PF01370.21 EEA18652.1 - 1.5e-10 41.0 0.0 5.1e-08 32.7 0.0 2.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Methyltransf_31 PF13847.6 EEA18652.1 - 6.3e-09 35.8 0.0 1.8e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA18652.1 - 3.7e-08 33.0 0.0 8.3e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 EEA18652.1 - 3.7e-05 23.4 2.0 4.1e-05 23.3 0.2 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase 3Beta_HSD PF01073.19 EEA18652.1 - 4.6e-05 22.6 0.0 0.00049 19.2 0.0 2.2 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 EEA18652.1 - 6.6e-05 22.4 0.1 0.00015 21.2 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain PP-binding PF00550.25 EEA18652.1 - 0.013 15.8 0.1 0.093 13.1 0.1 2.4 2 0 0 2 2 2 0 Phosphopantetheine attachment site NNMT_PNMT_TEMT PF01234.17 EEA18652.1 - 0.014 14.6 0.0 0.99 8.5 0.0 2.5 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Secretin_N PF03958.17 EEA18652.1 - 0.042 14.3 0.0 0.38 11.2 0.0 2.5 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain ACP_syn_III PF08545.10 EEA18652.1 - 0.18 11.7 0.5 1 9.2 0.3 2.3 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.16 EEA18653.1 - 3.5e-41 141.3 49.4 6.3e-41 140.5 47.8 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily ADH_zinc_N PF00107.26 EEA18654.1 - 4.3e-11 42.9 0.3 7.9e-11 42.0 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA18654.1 - 0.00094 19.0 0.0 0.0071 16.2 0.0 2.4 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EEA18654.1 - 0.0014 19.7 0.0 0.003 18.6 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EEA18655.1 - 3.9e-19 68.9 0.0 2e-17 63.3 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA18655.1 - 1.1e-12 48.0 0.1 6.5e-12 45.5 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA18655.1 - 1.4e-07 31.6 0.1 2e-07 31.1 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA18655.1 - 8.1e-05 22.2 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA18655.1 - 0.0016 17.9 0.0 0.0042 16.5 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF1601 PF07671.11 EEA18655.1 - 0.13 12.1 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1601) p450 PF00067.22 EEA18656.1 - 2.7e-30 105.5 0.1 3.5e-29 101.9 0.1 2.0 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EEA18657.1 - 1.4e-62 212.0 0.0 1.7e-62 211.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EEA18658.1 - 1.1e-68 232.1 0.0 2.6e-68 230.9 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 DUF962 PF06127.11 EEA18659.1 - 3.5e-26 91.1 0.0 6.6e-26 90.2 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF962 PF06127.11 EEA18660.1 - 6.2e-10 39.0 0.5 1.9e-09 37.5 0.5 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF962 PF06127.11 EEA18661.1 - 3.5e-26 91.1 0.0 6.6e-26 90.2 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF962 PF06127.11 EEA18662.1 - 1.7e-15 56.9 0.0 3e-15 56.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF962) SHS2_Rpb7-N PF03876.17 EEA18663.1 - 2.2e-15 56.8 0.0 4.3e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EEA18663.1 - 2.4e-09 37.4 0.0 3.7e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain Piwi PF02171.17 EEA18665.1 - 3.1e-70 236.8 0.0 4.6e-70 236.2 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EEA18665.1 - 4.1e-19 69.6 0.1 2.8e-18 66.9 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EEA18665.1 - 3.7e-11 42.5 0.0 1e-10 41.1 0.0 1.8 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EEA18665.1 - 4.6e-08 33.3 0.0 2e-07 31.2 0.0 2.1 2 0 0 2 2 2 1 Argonaute linker 2 domain DUF4141 PF13605.6 EEA18665.1 - 0.12 11.6 0.2 0.23 10.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) Fungal_trans PF04082.18 EEA18666.1 - 2.2e-12 46.6 0.0 5e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA18666.1 - 8.1e-08 32.3 12.4 1.3e-07 31.6 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HSBP1 PF06825.12 EEA18666.1 - 0.016 15.1 0.2 0.035 14.0 0.2 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 RRM_1 PF00076.22 EEA18667.1 - 1.1e-34 118.0 0.1 1.5e-18 66.4 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA18667.1 - 0.0013 18.8 0.1 0.38 10.9 0.1 3.1 3 1 0 3 3 3 2 RNA recognition motif SET_assoc PF11767.8 EEA18667.1 - 0.045 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated TPR_1 PF00515.28 EEA18668.1 - 1.9e-23 81.3 5.4 2.8e-09 36.4 0.0 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EEA18668.1 - 1.2e-22 78.1 5.7 1.5e-07 31.0 0.0 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EEA18668.1 - 3.4e-17 61.8 5.9 1.9e-08 33.8 0.1 4.8 4 2 1 5 5 5 3 TPR repeat TPR_16 PF13432.6 EEA18668.1 - 5.3e-17 62.2 3.6 1.1e-05 26.0 0.0 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA18668.1 - 1.9e-15 56.2 6.6 3.5e-05 24.3 0.0 6.5 5 1 2 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EEA18668.1 - 9.6e-15 53.8 3.1 0.0028 17.9 0.1 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 EEA18668.1 - 2.2e-13 49.3 3.9 7.5e-07 28.9 0.0 4.1 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA18668.1 - 7.6e-13 48.8 4.8 0.00023 21.6 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 EEA18668.1 - 4.3e-10 39.8 0.8 0.0055 17.0 0.1 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EEA18668.1 - 1.1e-09 37.6 0.2 0.0072 16.3 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA18668.1 - 1.8e-09 37.8 5.4 0.00012 22.3 0.2 4.5 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 EEA18668.1 - 1.3e-08 34.9 5.2 0.0042 17.2 0.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA18668.1 - 2.2e-05 24.6 1.9 0.011 15.9 0.2 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EEA18668.1 - 5.9e-05 23.5 4.0 2.3 9.0 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EEA18668.1 - 0.00046 19.5 3.2 0.13 11.4 0.5 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 EEA18668.1 - 0.0067 16.5 0.2 10 6.2 0.1 4.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain DUF1641 PF07849.11 EEA18668.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TPR_10 PF13374.6 EEA18668.1 - 0.019 14.8 5.7 0.086 12.7 0.3 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EEA18668.1 - 0.1 12.6 0.4 4.4 7.4 0.0 3.0 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF533 PF04391.12 EEA18668.1 - 0.2 11.2 5.2 2.7 7.5 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF533) DUF4192 PF13830.6 EEA18668.1 - 0.76 9.8 11.6 1.9 8.5 8.8 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4192) Glyco_hydro_20 PF00728.22 EEA18669.1 - 2.9e-97 326.3 0.4 3.9e-97 325.8 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EEA18669.1 - 4.2e-26 92.2 0.1 8.5e-26 91.2 0.1 1.5 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EEA18669.1 - 0.00023 21.9 0.1 0.00054 20.7 0.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DUF2247 PF10004.9 EEA18669.1 - 0.18 11.6 0.9 0.5 10.1 0.4 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2247) Chordopox_A13L PF05961.11 EEA18670.1 - 0.15 12.3 0.6 0.31 11.3 0.6 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF2070 PF09843.9 EEA18670.1 - 1.2 7.4 5.0 1.8 6.8 5.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Cu_amine_oxid PF01179.20 EEA18671.1 - 5.7e-156 519.5 0.0 7e-156 519.2 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EEA18671.1 - 5.6e-07 29.9 0.0 5.5e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EEA18671.1 - 2.3e-06 27.7 0.1 5.6e-06 26.5 0.1 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain FSAP_sig_propep PF03032.15 EEA18671.1 - 0.18 11.8 0.1 0.32 11.1 0.1 1.4 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide ThrE PF06738.12 EEA18672.1 - 2e-68 230.3 12.6 4e-64 216.3 3.3 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EEA18672.1 - 1.4e-11 44.6 5.5 1.4e-11 44.6 5.5 3.3 2 1 0 3 3 3 1 Threonine/Serine exporter, ThrE Peptidase_S58 PF03576.14 EEA18673.1 - 1.5e-112 376.0 1.1 1.9e-112 375.7 1.1 1.0 1 0 0 1 1 1 1 Peptidase family S58 RVT_2 PF07727.14 EEA18674.1 - 3.3e-38 131.7 0.2 5.9e-38 130.9 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA18674.1 - 1.8e-07 30.9 0.7 4.8e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 GAG-pre-integrase domain rve PF00665.26 EEA18674.1 - 0.00055 20.1 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA18674.1 - 0.026 14.1 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA18674.1 - 0.076 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA18674.1 - 0.12 12.6 3.2 0.31 11.3 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein Transformer PF06495.11 EEA18674.1 - 9.5 6.3 13.2 20 5.2 5.3 2.7 2 0 0 2 2 2 0 Fruit fly transformer protein REV1_C PF16727.5 EEA18675.1 - 0.078 13.4 4.0 5 7.6 0.5 2.4 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain IL32 PF15225.6 EEA18675.1 - 0.26 11.7 1.4 3.4 8.1 0.3 2.6 1 1 1 2 2 2 0 Interleukin 32 Pkinase PF00069.25 EEA18676.1 - 1.6e-17 63.7 0.0 2.9e-17 62.9 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA18676.1 - 4.5e-07 29.4 0.1 3.5e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase p450 PF00067.22 EEA18679.1 - 1.4e-22 80.1 0.1 1.4e-13 50.4 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 AA_permease_2 PF13520.6 EEA18680.1 - 3.8e-46 157.8 49.3 9.4e-44 149.9 41.4 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 EEA18680.1 - 1.9e-22 79.5 32.1 1.9e-22 79.5 32.1 1.6 2 0 0 2 2 2 1 Amino acid permease Aminotran_1_2 PF00155.21 EEA18681.1 - 1.4e-60 205.4 0.0 1.9e-60 205.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Dicty_REP PF05086.12 EEA18681.1 - 0.49 8.3 2.0 0.7 7.8 2.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF5427 PF10310.9 EEA18681.1 - 8.7 5.2 6.1 13 4.6 6.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Pro_racemase PF05544.11 EEA18682.1 - 1e-127 425.7 0.4 1.2e-127 425.5 0.4 1.0 1 0 0 1 1 1 1 Proline racemase AAA PF00004.29 EEA18683.1 - 3.9e-17 62.9 0.0 6.8e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA18683.1 - 0.00066 20.0 0.6 0.0027 18.0 0.1 2.1 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA18683.1 - 0.00089 19.3 0.1 0.0034 17.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA18683.1 - 0.0028 18.0 0.1 0.011 16.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EEA18683.1 - 0.0082 16.5 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain Torsin PF06309.11 EEA18683.1 - 0.015 15.4 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 Torsin AAA_30 PF13604.6 EEA18683.1 - 0.016 14.9 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EEA18683.1 - 0.053 13.2 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PNP_UDP_1 PF01048.20 EEA18685.1 - 1.2e-09 37.8 0.1 3.6e-09 36.2 0.1 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily ExoD PF06055.12 EEA18685.1 - 0.077 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Exopolysaccharide synthesis, ExoD SAS4 PF15460.6 EEA18686.1 - 8.5e-34 115.6 7.8 8.5e-34 115.6 7.8 2.3 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 PEHE PF15275.6 EEA18686.1 - 0.0066 17.1 1.5 0.0066 17.1 1.5 5.7 4 2 0 4 4 4 1 PEHE domain TetR_C_31 PF17940.1 EEA18687.1 - 0.012 15.8 0.6 0.033 14.4 0.1 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain APH PF01636.23 EEA18688.1 - 3.5e-08 33.7 0.3 6.7e-08 32.7 0.2 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA18688.1 - 1.6e-05 24.6 0.0 2.4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase TPR_10 PF13374.6 EEA18689.1 - 1.6e-88 288.5 14.3 8.9e-13 47.7 0.1 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.6 EEA18689.1 - 1.4e-67 223.9 11.8 5.2e-16 58.7 0.0 7.5 2 1 5 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 EEA18689.1 - 2.1e-30 102.5 7.8 0.004 17.1 0.0 9.1 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 EEA18689.1 - 6.2e-19 67.0 8.0 0.072 12.9 0.0 8.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 EEA18689.1 - 6.2e-18 63.4 7.6 0.12 12.5 0.0 8.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 EEA18689.1 - 4.6e-14 52.7 1.6 0.79 10.3 0.0 8.2 3 2 5 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 EEA18689.1 - 5.1e-13 48.1 13.2 0.38 11.1 0.1 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 EEA18689.1 - 7.3e-12 45.0 0.0 1.6e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily TPR_MalT PF17874.1 EEA18689.1 - 5.2e-09 35.9 20.5 3.1e-05 23.5 3.5 3.8 2 1 0 3 3 3 2 MalT-like TPR region NB-ARC PF00931.22 EEA18689.1 - 1.7e-08 34.0 0.0 4.8e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain TPR_4 PF07721.14 EEA18689.1 - 9.5e-08 32.0 0.0 30 5.6 0.0 7.1 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 EEA18689.1 - 1.8e-07 31.0 0.1 0.24 11.4 0.0 6.0 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA18689.1 - 2.3e-07 30.7 13.8 8.2 7.1 0.0 8.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA18689.1 - 5.3e-07 30.2 4.1 6.2 7.6 0.0 7.6 6 2 1 7 7 6 1 Tetratricopeptide repeat AAA_16 PF13191.6 EEA18689.1 - 3.2e-06 27.7 0.1 3.8e-05 24.1 0.0 2.7 2 1 0 2 2 1 1 AAA ATPase domain NACHT PF05729.12 EEA18689.1 - 1.3e-05 25.2 0.0 3.3e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain TPR_14 PF13428.6 EEA18689.1 - 0.00026 21.6 4.2 74 4.6 0.0 7.4 6 1 1 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA18689.1 - 0.0011 19.2 5.9 4.6 7.5 0.0 5.4 3 2 3 6 6 5 1 Anaphase-promoting complex, cyclosome, subunit 3 ATPase_2 PF01637.18 EEA18689.1 - 0.0047 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EEA18689.1 - 0.0063 16.8 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF4074 PF13293.6 EEA18689.1 - 0.0097 16.2 1.9 51 4.3 0.0 5.7 7 0 0 7 7 6 0 Domain of unknown function (DUF4074) SRP54 PF00448.22 EEA18689.1 - 0.016 14.9 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ParA PF10609.9 EEA18689.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase KdpD PF02702.17 EEA18689.1 - 0.12 11.8 0.1 5.7 6.4 0.0 2.9 2 1 0 2 2 2 0 Osmosensitive K+ channel His kinase sensor domain AAA_18 PF13238.6 EEA18689.1 - 0.12 12.9 0.0 0.37 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain RPN6_N PF18055.1 EEA18689.1 - 0.31 11.4 3.7 3.6 8.0 0.0 3.6 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain DUF1897 PF09005.10 EEA18689.1 - 0.52 9.8 8.7 6.3 6.4 0.4 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF1897) CutA1 PF03091.15 EEA18689.1 - 2.1 8.3 7.0 13 5.7 0.1 4.6 2 2 4 6 6 6 0 CutA1 divalent ion tolerance protein Pollen_allerg_1 PF01357.21 EEA18690.1 - 2.4e-09 37.1 0.0 4e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Pollen allergen DPBB_1 PF03330.18 EEA18690.1 - 0.0029 17.8 0.1 0.008 16.4 0.1 1.8 1 1 0 1 1 1 1 Lytic transglycolase Sugar_tr PF00083.24 EEA18691.1 - 3.1e-38 131.8 11.8 4e-38 131.4 11.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA18691.1 - 7.4e-30 104.1 20.1 7.4e-30 104.1 20.1 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA18691.1 - 2.7e-06 27.0 0.4 4.8e-06 26.1 0.4 1.3 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB ATG22 PF11700.8 EEA18691.1 - 7.6e-05 21.5 0.8 7.6e-05 21.5 0.8 2.0 2 0 0 2 2 2 1 Vacuole effluxer Atg22 like MFS_1_like PF12832.7 EEA18691.1 - 0.0028 16.6 3.0 0.068 12.0 0.4 2.8 3 0 0 3 3 3 2 MFS_1 like family MFS_1 PF07690.16 EEA18692.1 - 8e-33 113.8 53.1 1.2e-31 110.0 40.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA18692.1 - 2.2e-08 33.4 30.7 1.4e-05 24.2 9.7 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter AT_hook PF02178.19 EEA18693.1 - 4.6e-08 32.0 28.0 0.023 14.5 1.3 5.0 3 1 1 4 4 4 4 AT hook motif Macro PF01661.21 EEA18694.1 - 2.1e-11 43.9 0.0 1.5e-09 37.9 0.0 2.3 1 1 0 1 1 1 1 Macro domain DHDPS PF00701.22 EEA18695.1 - 2.1e-48 164.5 0.1 2.5e-48 164.3 0.1 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family MR_MLE_C PF13378.6 EEA18696.1 - 1.1e-53 182.0 0.1 1.5e-53 181.6 0.1 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EEA18696.1 - 2.7e-19 69.5 0.0 5.1e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain adh_short PF00106.25 EEA18697.1 - 3.2e-50 170.3 0.0 4.3e-50 169.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA18697.1 - 2.8e-49 167.8 0.2 5.7e-49 166.8 0.2 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA18697.1 - 6e-13 49.1 1.0 1.1e-12 48.2 0.1 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EEA18697.1 - 1.8e-05 24.3 0.1 2.5e-05 23.9 0.1 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_5 PF08323.11 EEA18697.1 - 0.00064 19.5 0.0 0.062 13.0 0.0 2.8 2 1 1 3 3 3 1 Starch synthase catalytic domain GDP_Man_Dehyd PF16363.5 EEA18697.1 - 0.014 14.8 0.1 0.021 14.3 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Glyco_transf_4 PF13439.6 EEA18697.1 - 0.034 14.1 0.0 4 7.4 0.0 2.9 3 0 0 3 3 3 0 Glycosyltransferase Family 4 NAD_binding_7 PF13241.6 EEA18697.1 - 0.044 14.2 0.0 0.092 13.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding PALP PF00291.25 EEA18697.1 - 0.05 13.0 0.1 0.076 12.4 0.1 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme NmrA PF05368.13 EEA18697.1 - 0.093 12.3 0.9 0.16 11.5 0.9 1.4 1 1 0 1 1 1 0 NmrA-like family ApbA PF02558.16 EEA18697.1 - 0.1 12.2 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Fungal_trans_2 PF11951.8 EEA18698.1 - 3.2e-16 59.1 2.7 1.2e-15 57.2 2.7 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain HsbA PF12296.8 EEA18699.1 - 3.5e-46 156.5 5.6 2.4e-22 79.6 0.0 3.7 3 1 1 4 4 4 2 Hydrophobic surface binding protein A ThylakoidFormat PF11264.8 EEA18699.1 - 0.1 12.2 0.6 4 7.1 0.0 2.9 3 0 0 3 3 3 0 Thylakoid formation protein AAA_lid_10 PF17872.1 EEA18699.1 - 0.15 12.2 1.2 0.62 10.2 0.6 2.0 2 0 0 2 2 2 0 AAA lid domain Flagellin_N PF00669.20 EEA18699.1 - 0.26 11.4 2.4 0.58 10.3 0.6 2.2 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region DUF1664 PF07889.12 EEA18699.1 - 0.85 9.7 4.2 2.6 8.1 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Fungal_trans PF04082.18 EEA18700.1 - 6.1e-19 68.1 0.0 1.2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA18700.1 - 4.4e-09 36.3 10.1 1e-08 35.1 10.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S28e PF01200.18 EEA18701.1 - 3e-31 107.2 2.3 3.4e-31 107.0 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e TusA PF01206.17 EEA18702.1 - 0.014 15.2 0.3 0.033 14.0 0.3 1.6 1 0 0 1 1 1 0 Sulfurtransferase TusA CAP_N PF01213.19 EEA18702.1 - 2.2 7.7 11.9 0.64 9.4 7.4 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal HsbA PF12296.8 EEA18703.1 - 4.9e-34 117.3 25.8 3.7e-19 69.3 1.5 5.3 4 2 1 5 5 5 2 Hydrophobic surface binding protein A Senescence PF06911.12 EEA18703.1 - 0.00062 20.1 1.6 1.5 9.1 0.0 3.2 2 0 0 2 2 2 2 Senescence-associated protein ThylakoidFormat PF11264.8 EEA18703.1 - 0.05 13.3 0.3 0.36 10.5 0.1 2.1 1 1 1 2 2 2 0 Thylakoid formation protein POTRA_3 PF17287.2 EEA18703.1 - 0.11 12.0 0.2 17 5.0 0.0 2.5 2 0 0 2 2 2 0 POTRA domain FliJ PF02050.16 EEA18703.1 - 0.13 12.5 0.2 10 6.4 0.3 2.6 2 0 0 2 2 2 0 Flagellar FliJ protein DUF5082 PF16888.5 EEA18703.1 - 0.18 12.1 0.7 31 4.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) F-box PF00646.33 EEA18704.1 - 0.75 9.7 0.0 0.75 9.7 0.0 2.8 3 0 0 3 3 3 0 F-box domain Hexokinase_1 PF00349.21 EEA18705.1 - 1e-41 143.0 0.0 1.7e-41 142.4 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EEA18705.1 - 5.7e-36 124.2 0.0 9e-36 123.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase SPT6_acidic PF14632.6 EEA18705.1 - 0.58 10.8 9.8 1.6 9.4 9.8 1.7 1 0 0 1 1 1 0 Acidic N-terminal SPT6 ABC2_membrane PF01061.24 EEA18707.1 - 2.5e-80 268.8 56.5 2e-45 154.8 24.2 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EEA18707.1 - 1.8e-36 125.7 0.0 5.3e-17 62.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EEA18707.1 - 8.6e-31 105.7 14.5 5.5e-29 99.9 0.0 3.6 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EEA18707.1 - 2.9e-17 63.0 0.0 7.2e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EEA18707.1 - 2e-07 31.5 0.2 0.00023 21.6 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA18707.1 - 4.1e-06 26.8 0.2 0.00034 20.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EEA18707.1 - 4.1e-05 23.2 0.4 0.00053 19.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 EEA18707.1 - 6.4e-05 22.9 0.1 1.5 8.5 0.1 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EEA18707.1 - 0.00063 19.5 0.3 0.2 11.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA18707.1 - 0.00099 19.3 0.1 0.12 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EEA18707.1 - 0.0013 18.4 0.4 0.42 10.2 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EEA18707.1 - 0.0016 18.2 1.3 0.027 14.2 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EEA18707.1 - 0.0023 18.5 0.1 0.17 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA18707.1 - 0.0024 18.2 0.2 1.1 9.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EEA18707.1 - 0.0063 16.5 3.0 4 7.3 0.2 3.3 3 0 0 3 3 3 2 NACHT domain DUF4209 PF13910.6 EEA18707.1 - 0.01 16.1 0.0 0.086 13.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4209) SMC_N PF02463.19 EEA18707.1 - 0.012 15.0 0.0 1.7 8.0 0.0 3.2 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA PF00004.29 EEA18707.1 - 0.019 15.4 0.2 3.6 8.0 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EEA18707.1 - 0.022 15.2 0.2 1.9 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EEA18707.1 - 0.024 15.0 0.5 1.9 8.8 0.1 3.0 3 0 0 3 3 3 0 AAA domain dNK PF01712.19 EEA18707.1 - 0.031 14.1 0.1 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_28 PF13521.6 EEA18707.1 - 0.038 14.3 0.1 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EEA18707.1 - 0.083 12.6 0.2 17 5.1 0.1 3.2 3 1 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 EEA18707.1 - 0.087 12.5 0.0 7.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 EEA18707.1 - 0.12 12.1 0.1 2.7 7.7 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 EEA18707.1 - 0.16 11.2 0.2 10 5.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin ABC2_membrane_3 PF12698.7 EEA18707.1 - 0.27 10.3 39.6 0.02 14.0 21.5 2.5 2 1 0 2 2 2 0 ABC-2 family transporter protein NTPase_1 PF03266.15 EEA18707.1 - 0.28 11.1 0.5 24 4.8 0.0 2.7 3 0 0 3 3 3 0 NTPase NifU_N PF01592.16 EEA18708.1 - 1.3e-35 122.4 0.0 1.7e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Aldo_ket_red PF00248.21 EEA18709.1 - 5.5e-59 199.8 0.0 6.2e-59 199.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Fungal_trans_2 PF11951.8 EEA18710.1 - 0.02 13.7 0.2 0.034 12.9 0.2 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain CENP-S PF15630.6 EEA18711.1 - 9.7e-36 122.0 0.0 1.4e-35 121.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EEA18711.1 - 7.5e-10 38.9 0.0 1e-09 38.5 0.0 1.4 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EEA18711.1 - 0.00066 19.6 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 EEA18711.1 - 0.013 15.9 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EEA18711.1 - 0.053 13.6 0.0 0.062 13.4 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DUF3433 PF11915.8 EEA18711.1 - 0.19 12.2 0.0 0.25 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3433) SLT PF01464.20 EEA18712.1 - 0.066 12.9 0.2 0.38 10.4 0.0 2.1 2 0 0 2 2 2 0 Transglycosylase SLT domain Pectate_lyase_3 PF12708.7 EEA18713.1 - 7.7e-68 228.5 24.3 2.7e-57 194.1 9.5 3.0 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EEA18713.1 - 0.0024 17.5 0.9 0.059 13.1 0.0 2.7 2 0 0 2 2 2 1 N terminal extension of bacteriophage endosialidase TMEM71 PF15121.6 EEA18713.1 - 0.03 14.0 0.2 0.061 13.0 0.2 1.4 1 0 0 1 1 1 0 TMEM71 protein family DUF1833 PF08875.11 EEA18713.1 - 0.067 12.7 0.1 1.3 8.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1833) tRNA-synt_1g PF09334.11 EEA18715.1 - 3.7e-140 467.1 0.1 1.1e-137 458.9 0.1 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EEA18715.1 - 7.6e-07 27.8 6.9 0.00015 20.2 0.0 3.6 3 1 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EEA18715.1 - 0.00011 22.2 0.4 0.00022 21.2 0.4 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA DUF1108 PF06531.11 EEA18715.1 - 0.19 12.0 0.0 0.5 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) BNR_2 PF13088.6 EEA18716.1 - 3.4e-08 33.1 0.0 1e-06 28.3 0.0 2.3 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.20 EEA18716.1 - 3.9e-07 29.1 9.3 1.8 8.9 0.5 5.3 4 0 0 4 4 4 4 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 EEA18716.1 - 0.0066 15.3 1.2 0.69 8.6 0.2 3.1 2 1 0 3 3 3 2 Sortilin, neurotensin receptor 3, Mo-co_dimer PF03404.16 EEA18716.1 - 0.021 14.9 0.2 9.5 6.2 0.0 3.4 4 0 0 4 4 4 0 Mo-co oxidoreductase dimerisation domain PGA2 PF07543.12 EEA18717.1 - 4.3e-20 72.1 25.8 2.9e-15 56.5 9.7 2.1 1 1 1 2 2 2 2 Protein trafficking PGA2 DUF4271 PF14093.6 EEA18717.1 - 0.057 13.3 0.0 0.082 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) SieB PF14163.6 EEA18717.1 - 0.23 11.0 0.8 0.8 9.2 0.0 2.1 2 0 0 2 2 2 0 Super-infection exclusion protein B SpoIIIAH PF12685.7 EEA18717.1 - 0.36 10.6 20.6 0.98 9.2 20.6 1.6 1 1 0 1 1 1 0 SpoIIIAH-like protein SLC12 PF03522.15 EEA18717.1 - 0.42 9.6 15.0 0.59 9.1 15.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 XRN_M PF17846.1 EEA18717.1 - 1.4 7.8 11.8 1.7 7.5 11.8 1.3 1 0 0 1 1 1 0 Xrn1 helical domain Neur_chan_memb PF02932.16 EEA18717.1 - 2.3 8.2 10.7 3.2 7.7 10.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LAP1C PF05609.12 EEA18717.1 - 3.1 6.8 23.9 4.2 6.3 23.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Membralin PF09746.9 EEA18717.1 - 10 5.1 8.9 14 4.6 8.9 1.3 1 0 0 1 1 1 0 Tumour-associated protein Glyco_hydro_61 PF03443.14 EEA18718.1 - 0.0036 17.3 1.6 0.017 15.1 0.0 2.7 2 1 0 2 2 2 1 Glycosyl hydrolase family 61 LPMO_10 PF03067.15 EEA18718.1 - 0.054 14.1 0.6 0.18 12.4 0.0 2.0 2 1 0 2 2 2 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading UvdE PF03851.14 EEA18719.1 - 4.5e-112 373.8 0.0 6.5e-112 373.3 0.0 1.2 1 0 0 1 1 1 1 UV-endonuclease UvdE Shugoshin_C PF07557.11 EEA18719.1 - 5 7.0 10.0 0.16 11.8 2.7 2.5 2 0 0 2 2 2 0 Shugoshin C terminus MFS_1 PF07690.16 EEA18720.1 - 1.3e-34 119.7 32.1 1.3e-34 119.7 32.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA18720.1 - 1.1e-13 50.8 2.8 1.1e-13 50.8 2.8 2.9 2 1 0 3 3 3 1 Sugar (and other) transporter DUF4112 PF13430.6 EEA18720.1 - 0.43 10.9 3.1 0.45 10.8 0.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4112) DUF423 PF04241.15 EEA18720.1 - 2.1 8.6 7.1 0.35 11.1 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF423) Zn_clus PF00172.18 EEA18721.1 - 9.1e-09 35.3 2.5 9.1e-09 35.3 2.5 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2183 PF09949.9 EEA18723.1 - 9e-34 115.8 0.0 2.4e-33 114.4 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) DUF4611 PF15387.6 EEA18725.1 - 0.026 14.7 2.9 0.026 14.7 2.9 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.11 EEA18725.1 - 0.53 8.3 4.3 0.7 7.9 4.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MARVEL PF01284.23 EEA18726.1 - 8e-06 25.9 10.8 1.2e-05 25.4 10.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain FMO-like PF00743.19 EEA18727.1 - 3e-16 59.0 0.0 6.6e-16 57.8 0.0 1.5 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA18727.1 - 1.4e-12 47.5 0.0 3.6e-11 42.9 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA18727.1 - 3e-12 46.3 0.0 3.3e-10 39.6 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EEA18727.1 - 5.4e-09 36.2 0.0 1.5e-07 31.5 0.0 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EEA18727.1 - 2.6e-06 27.3 0.1 0.0073 15.9 0.3 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA18727.1 - 5.7e-06 25.8 0.0 0.00012 21.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA18727.1 - 1.1e-05 25.5 0.0 4.1e-05 23.7 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA18727.1 - 0.00064 19.0 0.1 0.0023 17.2 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EEA18727.1 - 0.019 14.0 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EEA18727.1 - 0.027 13.8 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NIR_SIR PF01077.22 EEA18727.1 - 0.033 13.7 0.1 0.1 12.1 0.1 1.8 2 0 0 2 2 2 0 Nitrite and sulphite reductase 4Fe-4S domain FAD_binding_2 PF00890.24 EEA18727.1 - 0.053 12.6 0.4 6.4 5.7 0.4 2.2 1 1 1 2 2 2 0 FAD binding domain HI0933_like PF03486.14 EEA18727.1 - 0.098 11.3 0.4 11 4.5 0.0 2.5 3 0 0 3 3 3 0 HI0933-like protein Mqo PF06039.15 EEA18727.1 - 0.12 10.9 0.1 1.5 7.3 0.0 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Ribosomal_L19e PF01280.20 EEA18728.1 - 0.39 10.8 7.2 0.34 11.0 5.3 1.8 1 1 1 2 2 2 0 Ribosomal protein L19e DUF1481 PF07356.12 EEA18728.1 - 0.51 10.1 6.6 0.31 10.8 1.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1481) Sec1 PF00995.23 EEA18729.1 - 1.2e-115 387.9 0.0 1.4e-115 387.7 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Pkinase PF00069.25 EEA18730.1 - 1.9e-69 234.0 0.0 2.6e-69 233.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA18730.1 - 1.5e-34 119.5 0.0 2.1e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA18730.1 - 7.3e-06 25.5 0.0 1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA18730.1 - 0.0018 17.7 0.1 0.0035 16.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EEA18730.1 - 0.0081 15.7 0.1 0.048 13.2 0.0 2.1 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL DUF1757 PF08560.10 EEA18731.1 - 0.016 15.3 0.0 0.031 14.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1757) DUF3493 PF11998.8 EEA18731.1 - 0.047 13.9 0.5 3 8.1 0.0 2.5 1 1 1 2 2 2 0 Low psii accumulation1 / Rep27 Lipase PF00151.19 EEA18731.1 - 0.21 10.8 0.0 0.29 10.4 0.0 1.1 1 0 0 1 1 1 0 Lipase EF-hand_1 PF00036.32 EEA18733.1 - 6e-25 84.9 10.8 3.6e-08 32.4 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EEA18733.1 - 8.7e-25 87.0 5.7 1.9e-15 57.1 0.7 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EEA18733.1 - 9.5e-24 81.3 4.9 1e-06 28.2 0.1 5.2 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EEA18733.1 - 8.7e-17 59.8 11.6 5e-05 22.6 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 EEA18733.1 - 3.3e-13 49.3 10.8 0.00041 20.1 0.2 4.8 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_4 PF12763.7 EEA18733.1 - 4.4e-10 39.4 4.7 0.0025 17.7 0.2 4.0 2 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EEA18733.1 - 0.00015 22.0 0.6 0.011 16.0 0.1 3.1 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EEA18733.1 - 0.0087 16.4 1.9 1.1 9.6 0.3 3.2 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EEA18733.1 - 0.027 14.3 1.5 5.9 6.8 0.1 3.6 4 0 0 4 4 4 0 EF hand DUF1679 PF07914.11 EEA18733.1 - 0.11 11.3 0.4 8.9 5.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) NAD_binding_10 PF13460.6 EEA18734.1 - 5.3e-08 33.0 0.0 5.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA18734.1 - 2.1e-07 30.3 0.0 1.3e-06 27.7 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA18734.1 - 1.3e-05 24.8 0.0 2.5e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA18734.1 - 0.00058 19.1 0.0 0.021 14.0 0.0 2.4 3 0 0 3 3 3 1 Male sterility protein DapB_N PF01113.20 EEA18734.1 - 0.00095 19.3 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EEA18734.1 - 0.0044 17.4 0.0 0.0073 16.7 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EEA18734.1 - 0.086 11.9 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain EMP70 PF02990.16 EEA18735.1 - 2.2e-200 666.7 5.2 3.1e-200 666.3 5.2 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 HSP9_HSP12 PF04119.12 EEA18736.1 - 0.11 12.9 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 Heat shock protein 9/12 Sas10_Utp3 PF04000.15 EEA18737.1 - 1.6e-18 67.1 0.2 1.6e-18 67.1 0.2 1.9 2 0 0 2 2 2 1 Sas10/Utp3/C1D family GCP5-Mod21 PF14609.6 EEA18737.1 - 0.68 8.2 3.0 0.89 7.8 3.0 1.1 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 Striatin PF08232.12 EEA18737.1 - 1.1 9.9 9.1 8.3 7.0 9.2 2.4 1 1 0 1 1 1 0 Striatin family CENP-B_dimeris PF09026.10 EEA18737.1 - 3.7 8.0 11.0 8 6.9 11.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EEA18737.1 - 5.1 6.3 11.7 9.6 5.4 11.7 1.4 1 0 0 1 1 1 0 NOA36 protein Cerato-platanin PF07249.12 EEA18738.1 - 2.7e-36 124.3 1.4 3.2e-36 124.0 1.4 1.1 1 0 0 1 1 1 1 Cerato-platanin DUF5127 PF17168.4 EEA18739.1 - 2.9e-76 256.2 6.0 4.9e-76 255.5 6.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 EEA18739.1 - 2.8e-74 248.5 0.6 5.5e-74 247.6 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 EEA18739.1 - 3.1e-66 222.9 1.1 3.1e-66 222.9 1.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 EEA18739.1 - 9.3e-08 31.5 0.2 4.9e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4964) Phage_T4_gp36 PF03903.13 EEA18739.1 - 0.0064 16.5 1.5 0.018 15.0 0.9 2.1 2 0 0 2 2 2 1 Phage T4 tail fibre DUF5127 PF17168.4 EEA18740.1 - 1.6e-76 257.1 6.0 2.5e-76 256.5 6.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 EEA18740.1 - 8.4e-71 237.2 0.3 1.5e-70 236.4 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF4964 PF16334.5 EEA18740.1 - 6.9e-08 31.9 0.2 3.1e-07 29.8 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4964) Pro-kuma_activ PF09286.11 EEA18741.1 - 7.3e-47 159.2 0.2 2.3e-46 157.6 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EEA18741.1 - 0.00017 21.0 3.0 0.00033 20.0 3.0 1.4 1 0 0 1 1 1 1 Subtilase family DJ-1_PfpI PF01965.24 EEA18742.1 - 6.1e-09 35.9 0.0 1.4e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EEA18742.1 - 0.043 13.5 0.0 0.14 11.8 0.0 1.9 1 1 0 1 1 1 0 ThiJ/PfpI family-like Ntox1 PF15500.6 EEA18742.1 - 0.079 13.3 0.0 0.88 10.0 0.0 2.1 2 0 0 2 2 2 0 Putative RNase-like toxin, toxin_1 PASTA PF03793.19 EEA18742.1 - 0.16 11.9 0.0 0.49 10.3 0.0 1.8 2 0 0 2 2 2 0 PASTA domain Fungal_trans PF04082.18 EEA18743.1 - 1.2e-21 76.9 1.5 1.9e-21 76.3 1.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA18743.1 - 1.1e-07 31.8 11.2 1.8e-07 31.1 11.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCD48 PF15799.5 EEA18743.1 - 0.021 13.2 1.2 0.26 9.6 0.8 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 48 Not3 PF04065.15 EEA18743.1 - 0.029 13.8 0.1 0.062 12.7 0.1 1.5 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component CCCAP PF15964.5 EEA18743.1 - 0.08 11.2 0.6 0.12 10.7 0.6 1.2 1 0 0 1 1 1 0 Centrosomal colon cancer autoantigen protein family Csm1_N PF18504.1 EEA18743.1 - 0.12 12.8 0.3 2.7 8.4 0.4 2.6 2 0 0 2 2 2 0 Csm1 N-terminal domain p450 PF00067.22 EEA18744.1 - 1.2e-72 245.2 0.0 1.5e-72 244.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mito_carr PF00153.27 EEA18745.1 - 1.1e-58 195.2 5.4 1.6e-19 69.6 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein TRP PF06011.12 EEA18746.1 - 7.9e-40 136.9 26.5 1.4e-33 116.3 20.9 2.3 2 0 0 2 2 2 2 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EEA18746.1 - 1.1e-21 77.7 0.0 1.6e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 ML-like domain Methyltransf_23 PF13489.6 EEA18748.1 - 4.9e-13 49.2 0.2 8.9e-13 48.4 0.2 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA18748.1 - 3.9e-08 33.9 0.0 1e-07 32.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA18748.1 - 1e-06 29.4 0.0 2.3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA18748.1 - 0.00022 21.8 0.0 0.00067 20.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA18748.1 - 0.045 13.5 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EEA18748.1 - 0.051 13.0 0.0 0.093 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.18 EEA18748.1 - 0.055 12.8 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain MTS PF05175.14 EEA18748.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain ThiS PF02597.20 EEA18749.1 - 8.7e-05 23.1 0.0 0.00076 20.1 0.0 1.9 1 1 0 1 1 1 1 ThiS family Cys_Met_Meta_PP PF01053.20 EEA18750.1 - 3.3e-60 203.7 0.0 9e-60 202.2 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EEA18750.1 - 0.0054 15.7 0.0 0.0072 15.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EEA18750.1 - 0.0066 15.7 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II RNB PF00773.19 EEA18752.1 - 6.9e-45 153.8 0.0 1.3e-30 106.9 0.0 2.6 2 1 1 3 3 3 2 RNB domain Tom6 PF17112.5 EEA18753.1 - 0.0027 17.2 0.9 0.0038 16.7 0.1 1.7 2 0 0 2 2 2 1 Mitochondrial import receptor subunit Tom6, fungal CTNNBL PF08216.11 EEA18754.1 - 3.1e-40 136.5 1.5 9.2e-40 135.0 0.2 2.4 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 EEA18754.1 - 3.5e-05 23.7 0.1 0.12 12.4 0.0 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Neurochondrin PF05536.11 EEA18754.1 - 0.0012 17.3 0.2 0.0032 15.9 0.0 1.8 2 0 0 2 2 2 1 Neurochondrin MMS19_C PF12460.8 EEA18754.1 - 0.0014 17.8 3.5 0.048 12.8 0.4 2.3 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal Mo25 PF08569.11 EEA18754.1 - 0.029 13.8 2.3 0.1 11.9 1.8 2.2 1 1 2 3 3 3 0 Mo25-like V-ATPase_H_C PF11698.8 EEA18754.1 - 0.03 14.5 0.3 1.1 9.3 0.0 3.5 4 0 0 4 4 4 0 V-ATPase subunit H Drf_GBD PF06371.13 EEA18754.1 - 0.031 13.8 1.1 0.084 12.4 0.1 2.2 2 1 0 2 2 2 0 Diaphanous GTPase-binding Domain PHTB1_C PF14728.6 EEA18754.1 - 0.043 12.9 0.8 0.09 11.9 0.8 1.5 1 0 0 1 1 1 0 PTHB1 C-terminus HEAT_2 PF13646.6 EEA18754.1 - 0.053 13.9 0.8 0.51 10.8 0.3 2.8 1 1 1 2 2 2 0 HEAT repeats CTNNBL PF08216.11 EEA18755.1 - 1.9e-40 137.2 1.5 7.1e-40 135.4 0.2 2.5 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 EEA18755.1 - 2e-05 24.5 0.1 0.1 12.7 0.0 3.3 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 EEA18755.1 - 0.0011 18.2 3.8 0.039 13.1 0.4 2.3 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal Neurochondrin PF05536.11 EEA18755.1 - 0.0022 16.5 0.0 0.0022 16.5 0.0 1.9 3 0 0 3 3 3 1 Neurochondrin V-ATPase_H_C PF11698.8 EEA18755.1 - 0.015 15.4 0.3 0.9 9.7 0.0 3.6 4 0 0 4 4 4 0 V-ATPase subunit H Mo25 PF08569.11 EEA18755.1 - 0.016 14.6 2.2 0.074 12.4 1.6 2.3 1 1 1 2 2 2 0 Mo25-like Drf_GBD PF06371.13 EEA18755.1 - 0.025 14.1 1.5 0.065 12.8 0.1 2.4 2 1 0 3 3 3 0 Diaphanous GTPase-binding Domain PHTB1_C PF14728.6 EEA18755.1 - 0.032 13.4 0.8 0.071 12.2 0.8 1.5 1 0 0 1 1 1 0 PTHB1 C-terminus HEAT_2 PF13646.6 EEA18755.1 - 0.034 14.5 0.9 0.4 11.1 0.3 3.0 1 1 1 2 2 2 0 HEAT repeats RNA_pol_Rpb2_6 PF00562.28 EEA18756.1 - 1.2e-123 413.1 0.0 1.8e-123 412.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EEA18756.1 - 1.8e-57 194.1 0.0 3.5e-57 193.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EEA18756.1 - 1.9e-46 158.1 0.0 3.2e-46 157.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EEA18756.1 - 6.9e-33 112.9 0.0 1.5e-32 111.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EEA18756.1 - 1.4e-25 89.3 0.5 3.2e-25 88.1 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EEA18756.1 - 1.4e-24 86.2 0.8 4.7e-24 84.5 0.8 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EEA18756.1 - 3.1e-21 75.7 0.2 9.6e-21 74.1 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 AMPK1_CBM PF16561.5 EEA18757.1 - 6.8e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase SPX PF03105.19 EEA18757.1 - 2.4 8.0 8.3 3.1 7.6 8.3 1.1 1 0 0 1 1 1 0 SPX domain Beta-lactamase PF00144.24 EEA18758.1 - 9.6e-47 159.8 0.0 1.4e-46 159.3 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EEA18758.1 - 2.6e-12 47.1 0.0 4.6e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Nucleopor_Nup85 PF07575.13 EEA18759.1 - 3.8e-25 88.5 0.0 2.9e-18 65.8 0.0 2.3 2 0 0 2 2 2 2 Nup85 Nucleoporin FYDLN_acid PF09538.10 EEA18759.1 - 0.17 12.6 15.0 9.4 7.0 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Nop14 PF04147.12 EEA18759.1 - 0.25 9.5 14.3 0.37 8.9 14.3 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EEA18759.1 - 1.1 8.7 15.3 1.7 8.0 15.3 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EEA18759.1 - 6.9 4.8 10.3 10 4.2 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_A_exo1 PF01612.20 EEA18760.1 - 1.8e-15 57.1 0.0 2.3e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease IDO PF01231.18 EEA18761.1 - 1.5e-37 129.4 0.0 2e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase F-box PF00646.33 EEA18762.1 - 1.2e-11 44.1 1.2 2.9e-11 42.9 1.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EEA18762.1 - 6.2e-09 35.6 0.9 1.4e-08 34.5 0.9 1.5 1 0 0 1 1 1 1 F-box-like TPR_12 PF13424.6 EEA18762.1 - 0.00012 22.3 3.1 0.0015 18.8 0.3 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA18762.1 - 0.00014 21.7 8.0 0.1 12.7 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA18762.1 - 0.011 15.7 2.4 3.1 8.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_8 PF13855.6 EEA18762.1 - 0.017 14.9 7.6 0.065 13.0 0.0 4.7 4 2 1 5 5 4 0 Leucine rich repeat PPR PF01535.20 EEA18762.1 - 0.018 15.2 1.2 7.4 7.1 0.1 3.3 3 0 0 3 3 3 0 PPR repeat TPR_1 PF00515.28 EEA18762.1 - 0.027 14.3 8.1 1.9 8.5 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EEA18762.1 - 0.028 14.1 0.1 0.11 12.2 0.1 2.0 2 0 0 2 2 2 0 TPR repeat NARP1 PF12569.8 EEA18762.1 - 0.034 13.1 1.9 0.049 12.5 1.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 EEA18762.1 - 0.036 14.6 2.8 4.7 7.8 1.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_4 PF12799.7 EEA18762.1 - 0.087 13.3 20.2 42 4.8 2.2 7.4 5 3 3 8 8 8 0 Leucine Rich repeats (2 copies) TPR_16 PF13432.6 EEA18762.1 - 0.097 13.3 3.2 1.2 9.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 EEA18762.1 - 0.12 12.2 0.5 2.1 8.1 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) TPR_14 PF13428.6 EEA18762.1 - 0.13 13.2 1.3 14 6.9 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 EEA18762.1 - 0.15 12.5 3.3 2.6 8.5 0.9 2.4 1 1 1 2 2 2 0 Bacterial transcriptional activator domain ANAPC3 PF12895.7 EEA18762.1 - 0.18 12.1 3.0 5.1 7.4 0.2 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EEA18762.1 - 5.4 7.5 5.5 2 8.9 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ADIP PF11559.8 EEA18763.1 - 4.8e-41 140.4 17.0 4.8e-41 140.4 17.0 2.0 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 EEA18763.1 - 0.0034 16.9 15.7 0.0034 16.9 15.7 2.2 2 0 0 2 2 2 1 Golgin subfamily A member 5 SOGA PF11365.8 EEA18763.1 - 0.013 16.6 5.5 0.013 16.6 5.5 3.6 4 0 0 4 4 4 0 Protein SOGA RepA_C PF04796.12 EEA18763.1 - 0.047 13.7 0.7 0.13 12.2 0.7 1.8 1 0 0 1 1 1 0 Plasmid encoded RepA protein sCache_2 PF17200.4 EEA18763.1 - 0.21 11.4 1.5 0.71 9.7 1.5 2.0 1 0 0 1 1 1 0 Single Cache domain 2 TMPIT PF07851.13 EEA18763.1 - 0.23 10.7 6.4 0.46 9.7 6.4 1.6 1 0 0 1 1 1 0 TMPIT-like protein Rx_N PF18052.1 EEA18763.1 - 0.28 11.5 9.8 0.6 10.4 2.1 3.5 2 1 1 3 3 3 0 Rx N-terminal domain HU-CCDC81_bac_2 PF18175.1 EEA18763.1 - 0.37 10.7 3.2 17 5.4 0.1 2.7 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 FAP206 PF12018.8 EEA18763.1 - 0.48 9.9 6.8 1.2 8.5 6.8 1.7 1 0 0 1 1 1 0 Domain of unknown function KxDL PF10241.9 EEA18763.1 - 1.3 9.4 11.1 1.7 9.0 7.6 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein Nup88 PF10168.9 EEA18763.1 - 1.7 6.4 15.5 0.21 9.4 9.6 1.9 1 1 0 1 1 1 0 Nuclear pore component Spc7 PF08317.11 EEA18763.1 - 5.3 5.8 22.9 0.08 11.8 14.9 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 EEA18763.1 - 6 7.2 12.3 38 4.6 0.1 3.7 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) PET117 PF15786.5 EEA18764.1 - 6e-26 90.5 1.8 6.9e-26 90.3 1.8 1.0 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial PAP_PilO PF06864.12 EEA18764.1 - 0.1 11.4 0.2 0.13 11.1 0.2 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) V-ATPase_G PF03179.15 EEA18765.1 - 1.4e-32 112.4 18.2 1.6e-32 112.2 18.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 EEA18765.1 - 0.0042 16.5 13.1 0.0042 16.5 13.1 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) ATP-synt_B PF00430.18 EEA18765.1 - 0.0075 16.3 19.7 0.015 15.4 11.1 2.1 1 1 1 2 2 2 2 ATP synthase B/B' CF(0) S_layer_C PF05124.12 EEA18765.1 - 0.053 13.5 3.7 0.059 13.4 3.7 1.0 1 0 0 1 1 1 0 S-layer like family, C-terminal region YusW PF14039.6 EEA18765.1 - 0.073 13.6 5.9 0.06 13.9 4.7 1.5 1 1 0 1 1 1 0 YusW-like protein V-ATPase_G_2 PF16999.5 EEA18765.1 - 0.2 12.1 16.5 0.3 11.5 16.5 1.3 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit ATP11 PF06644.11 EEA18765.1 - 1.3 8.7 9.7 1.4 8.6 9.7 1.0 1 0 0 1 1 1 0 ATP11 protein V_ATPase_I PF01496.19 EEA18765.1 - 8.8 4.1 7.8 10 3.9 7.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Arrestin_N PF00339.29 EEA18767.1 - 7.9e-15 55.2 0.4 2.9e-13 50.1 0.1 2.8 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 EEA18767.1 - 0.12 11.8 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Bul1 C terminus Pyr_redox_2 PF07992.14 EEA18769.1 - 3.4e-49 167.7 0.1 4.3e-49 167.3 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA18769.1 - 4.6e-15 55.9 0.4 3.9e-13 49.8 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EEA18769.1 - 1.1e-14 54.1 0.0 3.5e-14 52.5 0.0 1.8 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Pyr_redox_3 PF13738.6 EEA18769.1 - 9.3e-08 31.7 0.0 0.0017 17.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 EEA18769.1 - 3.4e-06 26.9 0.0 1.7e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Reductase_C PF14759.6 EEA18769.1 - 1.4e-05 25.5 0.0 5.4e-05 23.7 0.0 2.0 2 0 0 2 2 1 1 Reductase C-terminal NAD_binding_9 PF13454.6 EEA18769.1 - 0.00024 21.1 0.1 0.6 10.1 0.0 2.6 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 EEA18769.1 - 0.0055 15.9 0.0 2 7.5 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Kelch_1 PF01344.25 EEA18769.1 - 0.022 14.3 0.3 0.59 9.8 0.1 2.5 2 0 0 2 2 2 0 Kelch motif DUF1188 PF06690.11 EEA18769.1 - 0.024 14.2 0.1 0.041 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) HI0933_like PF03486.14 EEA18769.1 - 0.036 12.8 0.1 7.8 5.1 0.0 2.8 3 0 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 EEA18769.1 - 0.053 12.6 0.1 1.1 8.3 0.0 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A TrkA_N PF02254.18 EEA18769.1 - 0.065 13.5 0.3 1.9 8.8 0.1 2.6 2 0 0 2 2 2 0 TrkA-N domain Amino_oxidase PF01593.24 EEA18769.1 - 0.13 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Phage_GP20 PF06810.11 EEA18770.1 - 0.012 15.5 4.6 0.012 15.5 4.6 3.1 2 1 2 4 4 4 0 Phage minor structural protein GP20 Bap31_Bap29_C PF18035.1 EEA18770.1 - 0.088 12.8 2.3 0.73 9.9 0.1 3.0 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF1639 PF07797.14 EEA18770.1 - 4.1 7.5 6.3 16 5.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) CLTH PF10607.9 EEA18771.1 - 4.6e-29 101.2 0.0 9.4e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EEA18771.1 - 1.2e-20 73.9 0.1 2e-20 73.1 0.1 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EEA18771.1 - 0.00015 21.6 0.3 0.0005 19.9 0.3 2.0 1 0 0 1 1 1 1 LisH CLTH PF10607.9 EEA18772.1 - 7.5e-25 87.6 0.0 1.6e-24 86.5 0.0 1.6 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EEA18772.1 - 1.1e-20 73.9 0.1 1.9e-20 73.1 0.1 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EEA18772.1 - 0.00032 20.5 1.4 0.00049 20.0 0.3 2.0 2 0 0 2 2 2 1 LisH ADH_zinc_N PF00107.26 EEA18773.1 - 8.7e-18 64.6 0.0 1.3e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EEA18773.1 - 3.1e-10 39.9 0.0 8.6e-10 38.5 0.0 1.7 1 1 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EEA18773.1 - 1.4e-07 32.7 0.0 2.4e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2534 PF10749.9 EEA18773.1 - 0.12 12.6 0.0 13 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) INO80_Ies4 PF08193.11 EEA18774.1 - 3.4e-53 181.1 18.6 3.4e-53 181.1 18.6 1.5 1 1 1 2 2 2 1 INO80 complex subunit Ies4 DnaJ PF00226.31 EEA18775.1 - 4.3e-14 52.4 0.1 7.2e-14 51.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain RPA43_OB PF17875.1 EEA18776.1 - 9.7e-41 139.3 0.1 9.7e-41 139.3 0.1 2.9 3 0 0 3 3 3 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EEA18776.1 - 0.00054 20.3 0.0 0.0016 18.8 0.0 1.9 2 1 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 FSA_C PF10479.9 EEA18776.1 - 1.2 7.2 6.3 1.8 6.6 6.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF4805 PF16063.5 EEA18776.1 - 5.1 6.4 10.9 0.98 8.7 7.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) Methyltransf_16 PF10294.9 EEA18777.1 - 2.9e-19 69.5 0.0 5e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EEA18777.1 - 0.0068 16.0 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EEA18777.1 - 0.14 12.9 0.0 0.25 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_S24e PF01282.19 EEA18778.1 - 2.5e-35 120.3 0.1 4.6e-35 119.4 0.0 1.5 1 1 1 2 2 2 1 Ribosomal protein S24e RRXRR PF14239.6 EEA18778.1 - 0.0037 17.1 2.2 0.0043 16.9 2.1 1.2 1 1 0 1 1 1 1 RRXRR protein FAD_binding_4 PF01565.23 EEA18778.1 - 0.043 13.6 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Ribosomal_S24e PF01282.19 EEA18779.1 - 9.9e-35 118.4 0.0 1.6e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e ArAE_2_N PF10337.9 EEA18780.1 - 5.3e-97 325.8 4.7 3e-94 316.7 0.9 2.2 2 0 0 2 2 2 2 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 EEA18780.1 - 9.3e-53 179.4 0.4 3.9e-51 174.1 0.2 2.3 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 EEA18780.1 - 1.8e-11 44.3 14.6 1.8e-11 44.3 14.6 3.9 4 1 0 4 4 4 1 Fusaric acid resistance protein-like Nup54_57_C PF18570.1 EEA18780.1 - 0.56 9.8 3.7 1.4 8.6 3.7 1.6 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain ALMT PF11744.8 EEA18780.1 - 2.6 6.8 15.1 0.048 12.5 7.5 1.8 2 0 0 2 2 2 0 Aluminium activated malate transporter Amidohydro_2 PF04909.14 EEA18781.1 - 2.5e-39 135.8 0.1 3e-39 135.6 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase DUF2678 PF10856.8 EEA18782.1 - 0.023 14.6 1.2 0.04 13.8 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) EMP70 PF02990.16 EEA18782.1 - 0.031 12.9 1.7 0.044 12.5 1.7 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 WD40 PF00400.32 EEA18783.1 - 4.3e-44 147.6 10.4 1.1e-05 26.1 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18783.1 - 9e-13 48.4 0.2 0.00079 19.7 0.0 5.0 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA18783.1 - 0.0052 16.1 0.0 8.5 5.6 0.1 3.3 2 1 2 4 4 4 2 WD40-like domain Nup160 PF11715.8 EEA18783.1 - 0.018 13.7 0.2 1.3 7.6 0.0 2.5 2 1 0 2 2 2 0 Nucleoporin Nup120/160 PQQ_2 PF13360.6 EEA18783.1 - 0.057 13.0 0.3 6 6.4 0.0 2.5 2 1 0 2 2 2 0 PQQ-like domain Nucleoporin_N PF08801.11 EEA18783.1 - 0.19 10.4 0.6 3.7 6.2 0.1 2.5 1 1 0 2 2 2 0 Nup133 N terminal like TRAPP PF04051.16 EEA18784.1 - 2.9e-36 124.4 0.0 3.6e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component RRM_1 PF00076.22 EEA18788.1 - 3.4e-45 151.7 0.0 7.2e-17 61.0 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EEA18788.1 - 5.6e-05 23.1 0.0 0.0012 18.9 0.0 2.6 3 0 0 3 3 3 1 RNA binding motif RRM_occluded PF16842.5 EEA18788.1 - 7.7e-05 22.5 0.0 0.054 13.4 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EEA18788.1 - 0.0002 21.3 0.1 0.0015 18.5 0.0 2.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EEA18788.1 - 0.00061 19.8 0.3 0.049 13.8 0.0 2.8 3 1 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.6 EEA18788.1 - 0.0078 15.8 0.0 0.054 13.1 0.0 2.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Statherin PF03875.13 EEA18788.1 - 2.8 8.1 7.2 9.5 6.4 7.2 2.0 1 0 0 1 1 1 0 Statherin TFB6 PF17110.5 EEA18789.1 - 1.1e-55 188.0 0.7 1.5e-55 187.5 0.0 1.5 2 0 0 2 2 2 1 Subunit 11 of the general transcription factor TFIIH PBP1_TM PF14812.6 EEA18789.1 - 1.2 9.5 8.1 5.1 7.5 1.2 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal His_Phos_1 PF00300.22 EEA18790.1 - 8.9e-15 54.9 1.0 1.4e-14 54.2 1.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RRM_Rrp7 PF17799.1 EEA18791.1 - 1.8e-30 105.9 0.0 2.6e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 EEA18791.1 - 2.1e-29 102.0 4.3 2.1e-29 102.0 4.3 1.8 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Rad51 PF08423.11 EEA18792.1 - 8.2e-112 372.6 0.0 1.1e-111 372.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EEA18792.1 - 3.7e-11 43.0 0.0 4.9e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 EEA18792.1 - 3.3e-08 34.0 1.1 6.4e-08 33.1 0.3 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 EEA18792.1 - 7.4e-07 28.8 0.0 1.6e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EEA18792.1 - 1.2e-05 24.9 0.0 3.1e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EEA18792.1 - 0.0035 17.1 0.0 0.015 15.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EEA18792.1 - 0.023 14.0 0.1 0.77 9.0 0.1 2.2 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain PAXNEB PF05625.11 EEA18792.1 - 0.1 11.7 0.0 1.3 8.0 0.0 2.1 2 0 0 2 2 2 0 PAXNEB protein Phage_HK97_TLTM PF06120.11 EEA18792.1 - 0.12 11.6 0.0 11 5.1 0.0 2.2 2 0 0 2 2 2 0 Tail length tape measure protein zf-CCHC PF00098.23 EEA18793.1 - 2.7e-43 144.2 57.6 2.3e-07 30.6 0.9 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EEA18793.1 - 1.6e-09 37.3 41.7 0.18 11.6 1.1 7.1 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_2 PF13696.6 EEA18793.1 - 0.0014 18.4 1.0 0.0014 18.4 1.0 7.1 7 0 0 7 7 7 3 Zinc knuckle zf-CCHC_3 PF13917.6 EEA18793.1 - 0.0016 18.4 46.5 0.012 15.5 0.5 6.9 3 2 2 5 5 5 4 Zinc knuckle zf-CCHC_5 PF14787.6 EEA18793.1 - 0.013 15.2 44.7 0.02 14.6 0.9 7.1 4 2 3 7 7 7 0 GAG-polyprotein viral zinc-finger UDPGP PF01704.18 EEA18794.1 - 3.1e-60 204.0 0.0 4.5e-60 203.4 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase MMS22L_C PF14911.6 EEA18794.1 - 0.23 10.5 0.4 0.44 9.6 0.1 1.6 2 0 0 2 2 2 0 S-phase genomic integrity recombination mediator, C-terminal Pro_isomerase PF00160.21 EEA18795.1 - 3.4e-34 118.4 0.0 5e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EEA18795.1 - 1.9e-15 56.4 0.6 5.1e-15 55.0 0.0 2.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EEA18796.1 - 1.3e-15 56.9 0.8 3.7e-15 55.5 0.0 2.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.21 EEA18796.1 - 1.3e-15 58.0 0.0 2.2e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Nup35_RRM_2 PF14605.6 EEA18796.1 - 0.18 11.8 0.0 0.41 10.7 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF5349 PF17298.2 EEA18797.1 - 0.9 9.2 6.9 2.7 7.7 3.3 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5349) DDE_1 PF03184.19 EEA18798.1 - 4.5e-24 85.0 0.0 9.1e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA18798.1 - 9e-09 35.2 0.3 3.1e-08 33.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Amidase PF01425.21 EEA18798.1 - 0.055 12.4 1.6 0.083 11.8 1.6 1.2 1 0 0 1 1 1 0 Amidase Glyco_hydro_47 PF01532.20 EEA18799.1 - 1.1e-117 393.8 0.0 1.5e-117 393.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Abhydrolase_1 PF00561.20 EEA18800.1 - 1.1e-12 48.2 0.1 2.6e-12 46.9 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA18800.1 - 1.3e-09 37.7 0.1 1.1e-08 34.7 0.1 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EEA18800.1 - 0.044 13.2 0.1 1 8.8 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 EEA18800.1 - 0.15 12.1 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Amidase PF01425.21 EEA18801.1 - 2.1e-52 178.6 0.5 6.6e-51 173.7 0.5 2.6 1 1 0 1 1 1 1 Amidase GGACT PF06094.12 EEA18802.1 - 0.00019 22.0 0.0 0.00046 20.8 0.0 1.7 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 EEA18802.1 - 0.00041 20.7 0.1 0.021 15.2 0.1 2.4 1 1 0 1 1 1 1 AIG2-like family GspH PF12019.8 EEA18802.1 - 0.0068 16.8 0.5 0.016 15.6 0.2 1.8 2 1 0 2 2 2 1 Type II transport protein GspH DNA_RNApol_7kD PF03604.13 EEA18803.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Pribosyltran PF00156.27 EEA18804.1 - 3.8e-17 62.3 0.0 5.2e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EEA18804.1 - 0.016 14.6 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Ribonuc_L-PSP PF01042.21 EEA18806.1 - 1.7e-37 128.1 0.1 2e-37 127.9 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP ADH_N PF08240.12 EEA18807.1 - 2.2e-22 79.0 4.7 3.3e-22 78.4 4.7 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA18807.1 - 3.1e-21 75.7 0.0 5.4e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA18807.1 - 1.4e-09 39.1 0.0 2.5e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA18807.1 - 0.0027 17.1 0.1 0.0044 16.4 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EEA18807.1 - 0.0053 16.1 0.0 0.0079 15.5 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF268 PF03269.14 EEA18807.1 - 0.18 11.6 0.0 0.43 10.4 0.0 1.6 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF268 Cupin_2 PF07883.11 EEA18808.1 - 1.1e-10 41.0 0.5 1.9e-10 40.3 0.5 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EEA18808.1 - 5.5e-06 26.1 0.0 7.6e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EEA18808.1 - 9.3e-05 22.4 0.2 0.00015 21.7 0.2 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.7 EEA18808.1 - 0.00022 21.0 0.4 0.00028 20.7 0.4 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EEA18808.1 - 0.00069 19.3 0.1 0.0011 18.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_7 PF12973.7 EEA18808.1 - 0.00074 19.4 0.1 0.0012 18.8 0.1 1.3 1 0 0 1 1 1 1 ChrR Cupin-like domain ADH_zinc_N PF00107.26 EEA18809.1 - 4.8e-30 104.2 0.6 8.4e-30 103.4 0.6 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA18809.1 - 1.4e-10 42.3 0.0 2.4e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA18809.1 - 1.1e-05 25.3 0.0 6.2e-05 22.8 0.0 2.3 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EEA18809.1 - 0.0022 17.5 0.4 0.0032 16.9 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase AlaDh_PNT_C PF01262.21 EEA18809.1 - 0.0046 16.3 0.8 0.0075 15.6 0.8 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EEA18809.1 - 0.0089 16.3 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain adh_short_C2 PF13561.6 EEA18809.1 - 0.01 15.4 0.6 0.015 14.9 0.6 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Acyl-CoA_dh_N PF02771.16 EEA18809.1 - 0.049 14.3 0.1 0.089 13.5 0.1 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain Clr5 PF14420.6 EEA18810.1 - 6.6e-13 48.7 1.4 1.6e-12 47.4 1.4 1.7 1 0 0 1 1 1 1 Clr5 domain Fungal_trans_2 PF11951.8 EEA18811.1 - 2.2e-05 23.5 0.7 4.1e-05 22.6 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 EEA18812.1 - 4.4e-50 170.4 0.0 5.4e-50 170.1 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA18812.1 - 3e-12 46.8 0.0 4e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA18812.1 - 2.6e-05 23.4 0.0 3.5e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DXP_reductoisom PF02670.16 EEA18812.1 - 0.052 14.3 0.0 0.089 13.5 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Fer2_4 PF13510.6 EEA18812.1 - 0.084 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Semialdhyde_dh PF01118.24 EEA18812.1 - 0.15 12.5 0.1 0.51 10.8 0.0 1.9 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain SNF2_N PF00176.23 EEA18813.1 - 7.2e-66 222.3 0.7 1.4e-65 221.4 0.7 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA18813.1 - 4.9e-20 71.9 0.0 1.8e-19 70.1 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA18813.1 - 2.1e-09 37.6 0.0 5.5e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HSA PF07529.13 EEA18813.1 - 4.6e-08 33.3 10.1 4.6e-08 33.3 10.1 3.0 3 0 0 3 3 3 1 HSA DEAD PF00270.29 EEA18813.1 - 0.00046 20.0 0.0 0.0016 18.2 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase SMAP PF15477.6 EEA18813.1 - 1.1 10.3 3.8 33 5.5 0.1 3.2 2 0 0 2 2 2 0 Small acidic protein family NDUF_B8 PF05821.11 EEA18814.1 - 5.2e-10 39.5 0.0 5.8e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Membr_traf_MHD PF10540.9 EEA18815.1 - 1.3e-19 70.8 0.6 7.2e-10 39.2 0.4 2.9 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EEA18815.1 - 5.8e-13 49.0 0.0 1.2e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 EEA18815.1 - 3.9e-08 32.3 1.0 2.1e-06 26.6 0.2 2.7 3 0 0 3 3 3 2 Plant family of unknown function (DUF810) ATP12 PF07542.11 EEA18816.1 - 6.7e-43 145.9 2.4 7.2e-43 145.7 1.3 1.6 2 0 0 2 2 2 1 ATP12 chaperone protein Pkinase_Tyr PF07714.17 EEA18818.1 - 2.1e-13 50.2 0.0 4.7e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EEA18818.1 - 6.9e-12 45.8 0.0 3.1e-06 27.7 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 EEA18818.1 - 8.2e-12 45.0 0.0 9.4e-11 41.6 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain Ank_3 PF13606.6 EEA18818.1 - 7.5e-09 35.1 1.0 0.0031 17.9 0.1 5.1 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EEA18818.1 - 1.9e-08 34.4 0.1 0.00034 20.9 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA18818.1 - 3.6e-08 33.8 0.3 0.00047 20.7 0.1 4.3 3 1 3 6 6 6 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA18818.1 - 0.00056 20.2 9.7 0.015 15.7 0.2 5.5 5 1 0 5 5 5 1 Ankyrin repeat Kdo PF06293.14 EEA18818.1 - 0.0013 18.2 0.0 0.0032 16.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Noc2 PF03715.13 EEA18818.1 - 0.045 13.0 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Noc2p family Glyco_tranf_2_3 PF13641.6 EEA18819.1 - 5.4e-32 111.5 0.1 7.1e-32 111.1 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EEA18819.1 - 1.1e-08 35.0 0.0 2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EEA18819.1 - 1.6e-06 27.8 0.0 2.5e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 EEA18819.1 - 0.004 17.1 4.2 0.009 15.9 4.2 1.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Phage_GPA PF05840.13 EEA18819.1 - 0.1 11.7 0.1 0.22 10.6 0.1 1.5 1 0 0 1 1 1 0 Bacteriophage replication gene A protein (GPA) Oxysterol_BP PF01237.18 EEA18820.1 - 7.7e-134 446.2 0.1 2.2e-133 444.7 0.0 1.8 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_5 PF13857.6 EEA18820.1 - 1.9e-14 53.5 0.2 1.5e-09 37.9 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA18820.1 - 5.9e-12 46.0 0.0 1.1e-07 32.4 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EEA18820.1 - 1.4e-11 44.3 0.1 0.0057 17.0 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EEA18820.1 - 1.9e-11 44.2 0.1 1.5e-05 25.5 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) PH PF00169.29 EEA18820.1 - 1.2e-10 41.8 0.4 2.7e-10 40.7 0.4 1.6 1 0 0 1 1 1 1 PH domain Ank_3 PF13606.6 EEA18820.1 - 1.3e-09 37.4 0.0 0.017 15.6 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat PH_8 PF15409.6 EEA18820.1 - 7.7e-07 29.3 0.6 2.1e-06 27.9 0.6 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EEA18820.1 - 0.00031 21.1 2.0 0.00031 21.1 2.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain LLC1 PF14945.6 EEA18820.1 - 0.7 10.5 5.7 0.14 12.7 1.4 2.0 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein zf-Mss51 PF13824.6 EEA18821.1 - 8e-29 99.5 5.1 8e-29 99.5 5.1 1.8 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EEA18821.1 - 0.0008 19.5 3.6 0.0015 18.5 0.4 2.3 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EEA18821.1 - 0.015 15.2 2.0 1.3 9.0 0.2 2.4 2 0 0 2 2 2 0 HIT zinc finger zf_UBZ PF18439.1 EEA18821.1 - 1.1 8.9 3.8 4.6 6.9 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Malic_M PF03949.15 EEA18824.1 - 2.7e-93 311.9 0.0 3.7e-93 311.5 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EEA18824.1 - 9.3e-67 224.3 0.0 1.6e-66 223.6 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain GCHY-1 PF02649.14 EEA18824.1 - 0.18 11.3 0.0 0.31 10.5 0.0 1.2 1 0 0 1 1 1 0 Type I GTP cyclohydrolase folE2 bZIP_1 PF00170.21 EEA18825.1 - 0.00012 22.1 2.4 0.00012 22.1 2.4 1.8 2 0 0 2 2 2 1 bZIP transcription factor ATG16 PF08614.11 EEA18825.1 - 0.29 11.4 9.9 0.061 13.5 5.2 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Na_Ca_ex PF01699.24 EEA18827.1 - 2e-38 131.7 47.3 2.1e-22 79.7 20.1 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Ras PF00071.22 EEA18829.1 - 1.3e-39 135.5 0.0 7.2e-39 133.0 0.0 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EEA18829.1 - 1.4e-28 99.5 0.0 2.4e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA18829.1 - 1.2e-10 41.1 0.0 5.7e-10 38.9 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA18829.1 - 2.5e-06 27.0 0.0 4.1e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA18829.1 - 4.6e-06 26.3 0.0 2.6e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EEA18829.1 - 0.00021 21.3 0.0 0.00038 20.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA18829.1 - 0.00058 19.8 0.0 0.038 13.9 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EEA18829.1 - 0.0018 17.8 0.0 0.0042 16.6 0.0 1.6 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 EEA18829.1 - 0.0034 17.2 0.1 0.019 14.7 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 EEA18829.1 - 0.013 15.7 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA18829.1 - 0.013 15.4 0.0 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 EEA18829.1 - 0.017 14.6 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EEA18829.1 - 0.019 15.2 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA18829.1 - 0.028 14.8 0.1 0.065 13.6 0.0 1.7 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EEA18829.1 - 0.033 14.5 0.1 0.088 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EEA18829.1 - 0.052 13.6 0.0 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EEA18829.1 - 0.06 13.9 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 EEA18829.1 - 0.077 12.7 0.0 0.45 10.2 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EEA18829.1 - 0.14 12.6 0.0 0.57 10.6 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EEA18829.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 EEA18829.1 - 0.17 11.6 0.6 0.7 9.6 0.0 2.1 3 0 0 3 3 3 0 AAA domain ADH_N PF08240.12 EEA18830.1 - 2e-33 114.5 0.1 4.1e-33 113.5 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA18830.1 - 8.2e-24 84.0 0.2 1.3e-23 83.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA18830.1 - 2.4e-09 37.0 0.5 6.9e-09 35.5 0.3 1.8 2 1 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EEA18830.1 - 0.00012 23.1 0.1 0.00027 22.0 0.1 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EEA18830.1 - 0.00035 19.9 0.8 0.00056 19.3 0.8 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EEA18830.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 EEA18830.1 - 0.023 13.9 0.3 0.07 12.4 0.4 1.8 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_25 PF13649.6 EEA18830.1 - 0.031 15.0 0.1 0.056 14.2 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain 2-Hacid_dh_C PF02826.19 EEA18830.1 - 0.039 13.3 0.0 0.077 12.3 0.0 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.14 EEA18830.1 - 0.078 11.7 0.1 0.11 11.1 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein AdoHcyase_NAD PF00670.21 EEA18830.1 - 0.16 12.1 0.8 0.33 11.0 0.5 1.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FAD-oxidase_C PF02913.19 EEA18831.1 - 1.5e-61 208.2 0.0 2.1e-61 207.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EEA18831.1 - 1.9e-37 128.1 0.0 3.2e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Clr5 PF14420.6 EEA18833.1 - 4.7e-19 68.4 0.8 2e-18 66.3 0.8 2.2 1 0 0 1 1 1 1 Clr5 domain Arabino_trans_C PF14896.6 EEA18833.1 - 0.075 12.0 1.4 0.18 10.8 0.7 1.8 1 1 1 2 2 2 0 EmbC C-terminal domain RNA_pol_N PF01194.17 EEA18834.1 - 3.9e-31 107.1 1.3 4.7e-31 106.9 1.3 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit WD40 PF00400.32 EEA18835.1 - 1.5e-05 25.6 4.5 0.14 13.1 0.1 5.9 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18835.1 - 0.00014 22.1 0.4 1.1 9.6 0.0 4.5 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF2396 PF09654.10 EEA18835.1 - 0.093 12.8 0.1 0.28 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2396) PP2C PF00481.21 EEA18836.1 - 3.4e-07 30.1 0.0 6.3e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Sugar_tr PF00083.24 EEA18837.1 - 2.2e-101 340.0 26.9 2.5e-101 339.8 26.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA18837.1 - 3.7e-23 82.0 33.5 4.4e-13 48.9 12.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA18837.1 - 0.00078 18.1 4.2 0.00078 18.1 4.2 3.1 2 2 1 3 3 3 2 MFS/sugar transport protein OATP PF03137.20 EEA18837.1 - 3 6.0 13.6 0.064 11.5 0.9 2.9 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DDE_1 PF03184.19 EEA18842.1 - 3.7e-31 108.1 0.0 7.4e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 EEA18842.1 - 8.4e-06 25.4 0.0 1.8e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain UPF0052 PF01933.18 EEA18842.1 - 0.14 11.4 1.3 9.6 5.3 0.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0052 zf-CCHC_2 PF13696.6 EEA18842.1 - 0.17 11.8 2.7 0.3 11.0 2.7 1.4 1 0 0 1 1 1 0 Zinc knuckle Mrpl_C PF18502.1 EEA18842.1 - 0.68 10.2 5.2 3.3 8.0 0.1 2.5 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain CENP-H PF05837.12 EEA18842.1 - 9.9 6.6 10.2 2.7 8.4 6.4 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) HTH_Tnp_Tc5 PF03221.16 EEA18843.1 - 3.6e-10 39.7 0.1 1e-09 38.3 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA18843.1 - 0.00011 21.8 0.0 0.0002 21.1 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_DeoR PF08220.12 EEA18843.1 - 0.034 13.9 0.1 0.061 13.1 0.1 1.4 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain SpoIIID PF12116.8 EEA18843.1 - 0.061 13.4 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_Tnp_ISL3 PF13542.6 EEA18843.1 - 0.084 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 EEA18843.1 - 0.085 12.7 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_28 PF13518.6 EEA18843.1 - 0.09 12.9 0.1 0.26 11.5 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 EEA18843.1 - 0.12 12.1 0.0 0.35 10.6 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 MerR PF00376.23 EEA18843.1 - 0.15 11.9 0.6 0.6 9.9 0.0 2.2 2 0 0 2 2 2 0 MerR family regulatory protein DDE_1 PF03184.19 EEA18844.1 - 6.9e-20 71.4 0.0 3.7e-19 69.0 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA18844.1 - 6.7e-15 54.9 1.0 7.5e-14 51.5 0.0 2.8 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain Med9 PF07544.13 EEA18844.1 - 0.025 14.7 1.3 0.21 11.7 0.6 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HTH_24 PF13412.6 EEA18844.1 - 0.059 12.9 0.0 0.19 11.3 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 EEA18844.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 LexA DNA binding domain Methyltransf_31 PF13847.6 EEA18845.1 - 1e-06 28.7 0.0 1.8e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA18845.1 - 4.4e-06 26.3 0.2 0.00082 19.0 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase small domain N6_Mtase PF02384.16 EEA18845.1 - 0.00011 21.6 0.0 0.00048 19.5 0.0 1.8 1 1 0 1 1 1 1 N-6 DNA Methylase PrmA PF06325.13 EEA18845.1 - 0.00046 19.7 0.0 0.00069 19.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EEA18845.1 - 0.0096 16.6 0.0 0.022 15.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 EEA18845.1 - 0.014 14.9 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_10 PF05971.12 EEA18845.1 - 0.017 14.5 0.0 0.075 12.3 0.0 1.9 1 1 0 1 1 1 0 RNA methyltransferase PrmC_N PF17827.1 EEA18845.1 - 0.027 15.1 0.4 0.11 13.1 0.2 2.1 2 1 0 2 2 2 0 PrmC N-terminal domain Methyltransf_12 PF08242.12 EEA18845.1 - 0.038 14.7 0.0 0.1 13.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 EEA18846.1 - 2.5e-06 26.7 34.0 2.5e-06 26.7 34.0 4.2 2 2 2 4 4 4 3 Major Facilitator Superfamily MRAP PF15183.6 EEA18846.1 - 0.13 12.2 3.4 3.8 7.5 0.1 3.9 3 0 0 3 3 3 0 Melanocortin-2 receptor accessory protein family Asp PF00026.23 EEA18847.1 - 5.3e-70 236.3 5.3 7.3e-70 235.9 5.3 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA18847.1 - 1.1e-11 45.3 7.0 1.1e-10 42.0 7.0 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA18847.1 - 0.0014 19.2 0.2 9.1 7.0 0.0 3.5 3 0 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 EEA18847.1 - 0.1 12.4 0.0 1.6 8.5 0.0 2.4 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal tRNA-synt_1b PF00579.25 EEA18848.1 - 1.2e-76 257.8 0.0 1.7e-76 257.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) HTH_20 PF12840.7 EEA18848.1 - 0.039 14.0 0.1 0.22 11.6 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Ribosomal_S10 PF00338.22 EEA18849.1 - 9.5e-29 99.5 0.0 1.9e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PNP_UDP_1 PF01048.20 EEA18850.1 - 2e-45 154.8 0.0 2.8e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily PNP_UDP_1 PF01048.20 EEA18851.1 - 2e-45 154.8 0.0 2.8e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Fcf2 PF08698.11 EEA18852.1 - 2.5e-36 124.0 0.1 5.2e-36 122.9 0.1 1.5 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing DUF4640 PF15480.6 EEA18852.1 - 0.017 14.9 1.2 0.024 14.4 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) CBFD_NFYB_HMF PF00808.23 EEA18853.1 - 7e-19 67.9 0.6 1.1e-18 67.2 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA18853.1 - 1.1e-15 58.2 0.2 1.8e-15 57.5 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EEA18853.1 - 0.039 14.3 0.0 0.085 13.2 0.0 1.6 1 1 0 1 1 1 0 CENP-S associating Centromere protein X G_path_suppress PF15991.5 EEA18853.1 - 1.4 9.0 5.2 0.67 10.0 0.6 2.0 2 0 0 2 2 2 0 G-protein pathway suppressor Sec15 PF04091.12 EEA18854.1 - 1e-111 373.4 1.8 1e-111 373.4 1.8 2.4 2 1 0 2 2 2 1 Exocyst complex subunit Sec15-like Sec8_exocyst PF04048.14 EEA18854.1 - 4.7e-05 23.3 4.5 4.7e-05 23.3 4.5 2.6 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain COG5 PF10392.9 EEA18854.1 - 0.00061 20.0 9.8 0.011 15.9 6.8 3.4 2 1 1 3 3 3 1 Golgi transport complex subunit 5 COG2 PF06148.11 EEA18854.1 - 0.0026 17.8 5.9 0.0026 17.8 5.9 2.7 2 1 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Sec5 PF15469.6 EEA18854.1 - 0.0053 16.6 10.8 0.038 13.8 3.9 3.1 2 1 1 3 3 3 2 Exocyst complex component Sec5 Vps51 PF08700.11 EEA18854.1 - 0.036 14.2 5.0 0.096 12.8 1.9 3.2 2 0 0 2 2 2 0 Vps51/Vps67 Mre11_DNA_bind PF04152.14 EEA18854.1 - 0.052 13.9 1.3 0.33 11.2 0.0 2.9 3 0 0 3 3 3 0 Mre11 DNA-binding presumed domain PUB PF09409.10 EEA18854.1 - 0.08 12.9 0.1 1.9 8.5 0.0 2.9 2 0 0 2 2 2 0 PUB domain KELK PF15796.5 EEA18854.1 - 0.14 12.6 2.5 0.81 10.2 1.0 2.9 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Vps54_N PF10475.9 EEA18854.1 - 0.15 11.3 11.8 0.05 12.9 7.8 2.0 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex DUF3510 PF12022.8 EEA18854.1 - 0.67 10.3 7.2 16 5.9 0.0 3.9 2 2 2 4 4 4 0 Domain of unknown function (DUF3510) MitMem_reg PF13012.6 EEA18854.1 - 2.1 8.8 10.2 13 6.2 5.1 3.9 3 1 0 3 3 3 0 Maintenance of mitochondrial structure and function RRM_2 PF04059.12 EEA18855.1 - 9.5e-32 109.1 0.4 1.7e-31 108.3 0.4 1.4 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EEA18855.1 - 8.5e-10 38.3 0.6 0.038 13.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4926 PF16277.5 EEA18855.1 - 0.15 11.4 0.0 3.9 6.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4926) adh_short PF00106.25 EEA18856.1 - 5.2e-19 68.5 0.1 1.3e-18 67.2 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA18856.1 - 2.5e-08 33.8 0.1 2.1e-07 30.8 0.1 2.1 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA18856.1 - 4.7e-06 26.6 1.4 0.00011 22.2 1.4 2.2 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA18856.1 - 0.028 13.5 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA18856.1 - 0.17 11.3 0.1 0.47 9.9 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Phosphodiest PF01663.22 EEA18857.1 - 8.4e-14 51.9 2.0 9.4e-09 35.3 0.1 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EEA18857.1 - 0.00041 19.9 0.1 0.011 15.1 0.0 2.1 2 0 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 EEA18857.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Inhibitor_G39P PF11417.8 EEA18857.1 - 0.13 12.8 0.1 0.52 10.9 0.1 2.0 2 0 0 2 2 2 0 Loader and inhibitor of phage G40P DUF229 PF02995.17 EEA18857.1 - 0.17 10.4 0.1 0.24 10.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Phosphodiest PF01663.22 EEA18858.1 - 8.4e-14 51.9 2.0 9.4e-09 35.3 0.1 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EEA18858.1 - 0.0004 19.9 0.1 0.011 15.1 0.0 2.1 2 0 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 EEA18858.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Inhibitor_G39P PF11417.8 EEA18858.1 - 0.13 12.8 0.1 0.52 10.9 0.1 2.0 2 0 0 2 2 2 0 Loader and inhibitor of phage G40P DUF229 PF02995.17 EEA18858.1 - 0.17 10.4 0.1 0.24 10.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF2423 PF10338.9 EEA18859.1 - 3.5e-22 78.4 1.0 3.5e-22 78.4 1.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) Peroxin-3 PF04882.12 EEA18859.1 - 0.15 11.0 10.8 0.18 10.8 10.8 1.0 1 0 0 1 1 1 0 Peroxin-3 TRAP_alpha PF03896.16 EEA18859.1 - 0.68 9.1 4.5 0.94 8.6 4.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PINIT PF14324.6 EEA18860.1 - 3e-42 144.4 0.1 5.6e-42 143.5 0.1 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EEA18860.1 - 5.5e-23 80.4 6.8 9.7e-23 79.7 6.8 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 EEA18860.1 - 5.6e-08 32.4 0.6 1.4e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 SAP domain zf-Nse PF11789.8 EEA18860.1 - 1e-06 28.4 3.1 2.3e-06 27.3 3.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-Sec23_Sec24 PF04810.15 EEA18860.1 - 0.092 12.8 2.8 0.26 11.4 2.8 1.8 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger zf-C3HC4_4 PF15227.6 EEA18860.1 - 1.2 9.3 5.8 2.4 8.4 5.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FA_hydroxylase PF04116.13 EEA18861.1 - 1.3e-25 90.3 16.7 1.3e-25 90.3 16.7 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily adh_short PF00106.25 EEA18862.1 - 6.9e-42 143.1 0.5 8.7e-42 142.8 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA18862.1 - 3.3e-30 105.4 0.1 4.1e-30 105.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EEA18862.1 - 3e-11 43.2 0.0 2.5e-09 36.9 0.0 2.5 2 1 0 2 2 2 1 Fungal family of unknown function (DUF1776) KR PF08659.10 EEA18862.1 - 1e-09 38.5 0.9 1.4e-09 38.1 0.3 1.4 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 EEA18862.1 - 6.4e-06 26.2 0.1 8.8e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA18862.1 - 7.4e-05 22.3 0.2 0.00034 20.2 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EEA18862.1 - 0.0018 17.8 0.3 0.0027 17.3 0.3 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EEA18862.1 - 0.0078 16.5 0.1 0.011 15.9 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 EEA18862.1 - 0.012 16.2 0.0 0.024 15.2 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EEA18862.1 - 0.014 14.8 0.4 0.065 12.6 0.2 2.1 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_Gly3P_dh_N PF01210.23 EEA18862.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 EEA18862.1 - 0.046 13.6 0.4 0.13 12.1 0.4 1.8 1 0 0 1 1 1 0 Rossmann-like domain ApbA PF02558.16 EEA18862.1 - 0.11 12.2 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EEA18862.1 - 0.13 12.2 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain WD40 PF00400.32 EEA18863.1 - 3.4e-61 201.8 14.1 1.4e-09 38.4 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18863.1 - 8.4e-20 70.9 0.1 0.00027 21.2 0.0 6.6 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Tup_N PF08581.10 EEA18863.1 - 1.2e-17 63.9 9.6 2.1e-17 63.2 9.6 1.4 1 0 0 1 1 1 1 Tup N-terminal WD40_like PF17005.5 EEA18863.1 - 9.9e-09 34.9 0.0 0.049 13.0 0.0 5.2 4 1 2 6 6 6 3 WD40-like domain Nup160 PF11715.8 EEA18863.1 - 4.6e-06 25.6 0.1 0.27 9.8 0.0 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EEA18863.1 - 1.7e-05 24.0 0.1 0.57 9.1 0.0 4.5 1 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EEA18863.1 - 5.4e-05 21.9 0.6 0.00045 18.9 0.2 2.5 1 1 1 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 EEA18863.1 - 0.00081 19.3 0.0 0.059 13.2 0.0 3.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EEA18863.1 - 0.034 13.5 0.1 7.1 5.9 0.0 2.8 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal TPX2 PF06886.11 EEA18863.1 - 1.2 9.5 5.0 2.5 8.4 5.0 1.5 1 1 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) UPF0242 PF06785.11 EEA18863.1 - 1.5 8.9 5.7 2.1 8.4 5.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2 PF00096.26 EEA18864.1 - 4.3e-14 52.1 37.1 5.7e-05 23.3 1.5 5.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA18864.1 - 1.7e-11 44.0 27.6 1.1e-07 32.0 2.2 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA18864.1 - 1.3e-05 25.6 33.7 0.0022 18.7 1.3 6.0 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EEA18864.1 - 0.25 11.5 5.8 14 5.8 0.2 3.7 1 1 1 3 3 3 0 Aberrant zinc-finger zf-C2H2_11 PF16622.5 EEA18864.1 - 0.65 9.8 10.4 0.19 11.5 0.5 3.6 3 0 0 3 3 3 0 zinc-finger C2H2-type Mito_carr PF00153.27 EEA18865.1 - 6.3e-68 224.8 5.0 9.2e-23 80.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA18865.1 - 0.00032 19.9 1.8 1.2 8.3 0.0 3.2 3 0 0 3 3 3 3 Gammaproteobacterial serine protease Tom7 PF08038.12 EEA18866.1 - 2.9e-22 78.1 0.6 3.3e-22 77.9 0.6 1.1 1 0 0 1 1 1 1 TOM7 family DUF4534 PF15049.6 EEA18866.1 - 0.033 13.9 0.0 0.033 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4534) RRM_1 PF00076.22 EEA18867.1 - 1.4e-33 114.5 0.0 1.7e-15 56.5 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA18867.1 - 0.0024 17.5 0.1 0.073 12.7 0.0 2.2 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA18867.1 - 0.0086 16.2 0.0 0.085 13.0 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif OB_RNB PF08206.11 EEA18867.1 - 0.01 15.5 0.5 1.1 9.0 0.1 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Cas_Cas2CT1978 PF09707.10 EEA18867.1 - 0.023 14.8 0.0 4.3 7.5 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) DUF2015 PF09435.10 EEA18868.1 - 4.6e-47 158.5 0.0 5.2e-47 158.3 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Ribosomal_L28e PF01778.17 EEA18869.1 - 9.9e-34 116.5 0.8 1.2e-33 116.2 0.8 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family Ldh_1_N PF00056.23 EEA18870.1 - 2.9e-44 150.6 0.0 4.2e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EEA18870.1 - 1e-43 149.2 0.0 1.4e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EEA18870.1 - 0.00028 20.0 0.0 0.00044 19.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EEA18870.1 - 0.02 14.4 0.1 1.9 8.0 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase THF_DHG_CYH_C PF02882.19 EEA18870.1 - 0.063 12.6 0.1 0.67 9.3 0.1 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_N PF00056.23 EEA18871.1 - 2.9e-44 150.6 0.0 4.2e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EEA18871.1 - 1e-43 149.2 0.0 1.4e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EEA18871.1 - 0.00028 20.0 0.0 0.00043 19.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EEA18871.1 - 0.02 14.5 0.1 1.9 8.0 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase THF_DHG_CYH_C PF02882.19 EEA18871.1 - 0.063 12.6 0.1 0.67 9.3 0.1 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_N PF00056.23 EEA18872.1 - 2.9e-44 150.6 0.0 4.2e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EEA18872.1 - 1e-43 149.2 0.0 1.4e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EEA18872.1 - 0.00028 20.0 0.0 0.00043 19.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EEA18872.1 - 0.02 14.5 0.1 1.9 8.0 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase THF_DHG_CYH_C PF02882.19 EEA18872.1 - 0.063 12.6 0.1 0.67 9.3 0.1 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_N PF00056.23 EEA18873.1 - 2.9e-44 150.6 0.0 4.2e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EEA18873.1 - 1e-43 149.2 0.0 1.4e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EEA18873.1 - 0.00028 20.0 0.0 0.00043 19.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EEA18873.1 - 0.02 14.5 0.1 1.9 8.0 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase THF_DHG_CYH_C PF02882.19 EEA18873.1 - 0.063 12.6 0.1 0.67 9.3 0.1 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_N PF00056.23 EEA18874.1 - 2.9e-44 150.6 0.0 4.2e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EEA18874.1 - 1e-43 149.2 0.0 1.4e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EEA18874.1 - 0.00028 20.0 0.0 0.00043 19.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EEA18874.1 - 0.02 14.5 0.1 1.9 8.0 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase THF_DHG_CYH_C PF02882.19 EEA18874.1 - 0.063 12.6 0.1 0.67 9.3 0.1 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TRAPP PF04051.16 EEA18875.1 - 1.1e-45 154.9 0.0 1.3e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component MIF4G_like PF09088.11 EEA18876.1 - 2.3e-89 298.2 0.1 4e-89 297.4 0.1 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EEA18876.1 - 6.6e-74 248.7 0.0 1.2e-73 247.9 0.0 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 EEA18876.1 - 0.22 11.1 0.3 1 9.0 0.0 2.2 3 0 0 3 3 3 0 MIF4G domain Pkinase PF00069.25 EEA18877.1 - 6.9e-66 222.3 0.0 8.1e-66 222.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA18877.1 - 1.4e-25 90.0 0.0 1.9e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA18877.1 - 1.3e-06 27.9 0.0 1.3e-05 24.7 0.0 2.0 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 EEA18877.1 - 0.0017 18.3 0.9 0.012 15.6 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA18877.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EEA18877.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Porin_3 PF01459.22 EEA18878.1 - 1.6e-83 280.3 0.1 1.9e-83 280.1 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin Zds_C PF08632.10 EEA18878.1 - 0.01 15.6 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term 6PF2K PF01591.18 EEA18879.1 - 1.8e-62 210.6 0.0 2.7e-62 210.0 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EEA18879.1 - 1.6e-20 73.6 0.6 9.4e-20 71.1 0.6 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.10 EEA18879.1 - 0.036 13.5 0.0 0.076 12.4 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 APS_kinase PF01583.20 EEA18879.1 - 0.04 13.8 0.1 0.43 10.5 0.1 2.2 1 1 0 1 1 1 0 Adenylylsulphate kinase AAA_33 PF13671.6 EEA18879.1 - 0.12 12.6 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Urm1 PF09138.11 EEA18880.1 - 4e-34 116.9 0.0 4.7e-34 116.6 0.0 1.1 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EEA18880.1 - 0.031 14.9 0.0 0.039 14.6 0.0 1.2 1 0 0 1 1 1 0 ThiS family WD40 PF00400.32 EEA18881.1 - 4.3e-34 116.0 29.8 1.6e-06 28.8 0.2 11.7 12 0 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18881.1 - 3.3e-14 52.9 1.8 0.028 14.7 0.0 6.5 5 2 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain ABC_tran PF00005.27 EEA18882.1 - 6.8e-16 59.0 0.4 3.1e-15 56.9 0.4 2.0 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EEA18882.1 - 2.3e-10 40.8 3.6 8.4e-05 22.5 0.8 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA18882.1 - 0.001 18.8 1.5 0.0024 17.6 1.5 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EEA18882.1 - 0.0019 17.7 0.0 0.79 9.1 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain PduV-EutP PF10662.9 EEA18882.1 - 0.0019 18.0 0.0 0.0027 17.5 0.0 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation DUF3584 PF12128.8 EEA18882.1 - 0.0022 15.6 0.5 0.0031 15.1 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_23 PF13476.6 EEA18882.1 - 0.0092 16.5 0.4 0.015 15.8 0.4 1.2 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 EEA18882.1 - 0.026 14.2 0.2 0.037 13.7 0.2 1.2 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EEA18882.1 - 0.028 14.3 0.3 0.044 13.7 0.3 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EEA18882.1 - 0.037 13.6 0.3 0.066 12.8 0.3 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EEA18882.1 - 0.044 14.0 0.8 0.081 13.2 0.8 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA18882.1 - 0.06 13.7 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain DLIC PF05783.11 EEA18882.1 - 0.099 11.4 0.2 0.16 10.8 0.2 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_13 PF13166.6 EEA18882.1 - 0.12 11.0 0.1 0.16 10.6 0.1 1.1 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 EEA18882.1 - 0.13 11.7 0.1 0.24 10.8 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_22 PF13401.6 EEA18882.1 - 0.13 12.5 0.1 0.36 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EEA18882.1 - 0.16 12.0 0.4 0.87 9.6 0.1 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EEA18882.1 - 0.17 12.3 0.2 0.83 10.1 0.2 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EEA18882.1 - 0.17 12.0 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Roc PF08477.13 EEA18882.1 - 0.17 12.1 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EEA18882.1 - 0.26 11.0 0.1 0.43 10.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EEA18882.1 - 0.28 10.8 0.1 0.44 10.2 0.1 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain IPPT PF01715.17 EEA18883.1 - 9.5e-64 215.3 0.3 1.4e-63 214.8 0.3 1.2 1 0 0 1 1 1 1 IPP transferase AAA_33 PF13671.6 EEA18883.1 - 6.9e-05 23.0 0.6 0.014 15.6 0.1 3.5 2 1 0 2 2 2 1 AAA domain zf-met PF12874.7 EEA18883.1 - 0.00023 21.4 0.3 0.0005 20.4 0.3 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type IPT PF01745.16 EEA18883.1 - 0.00073 19.0 0.0 0.0018 17.7 0.0 1.6 1 0 0 1 1 1 1 Isopentenyl transferase AAA_16 PF13191.6 EEA18883.1 - 0.0015 19.0 0.0 0.0062 16.9 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EEA18883.1 - 0.0028 18.2 0.4 0.83 10.2 0.0 2.9 2 1 0 2 2 2 1 AAA domain zf-C2H2_jaz PF12171.8 EEA18883.1 - 0.016 15.5 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EEA18883.1 - 0.016 15.5 0.2 0.031 14.6 0.2 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) AAA_22 PF13401.6 EEA18883.1 - 0.028 14.7 0.1 0.26 11.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF3449 PF11931.8 EEA18883.1 - 0.046 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Cytidylate_kin PF02224.18 EEA18883.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 EEA18883.1 - 0.18 12.3 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RAI1 PF08652.11 EEA18884.1 - 9.3e-27 93.0 0.0 1.8e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease DUF410 PF04190.13 EEA18885.1 - 2e-87 293.2 0.0 2.5e-87 292.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) His_Phos_2 PF00328.22 EEA18887.1 - 2.6e-06 27.0 0.0 0.0055 16.1 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Rep_fac_C PF08542.11 EEA18888.1 - 5.4e-24 84.4 0.0 1.5e-23 83.0 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EEA18888.1 - 3.1e-12 46.6 0.0 9e-09 35.3 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EEA18888.1 - 6.4e-11 42.8 0.0 1.1e-10 42.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EEA18888.1 - 8.1e-07 29.1 0.0 1.4e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA18888.1 - 1.6e-05 25.4 0.0 0.00055 20.4 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EEA18888.1 - 2.6e-05 24.1 0.0 4.1e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 EEA18888.1 - 3.9e-05 23.4 0.0 9.8e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 EEA18888.1 - 4e-05 23.5 0.0 8.3e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EEA18888.1 - 0.00014 21.7 0.0 0.00022 21.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EEA18888.1 - 0.00031 21.0 0.0 0.47 10.7 0.1 2.4 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 EEA18888.1 - 0.004 17.1 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EEA18888.1 - 0.0057 16.1 0.1 0.056 12.8 0.0 2.0 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EEA18888.1 - 0.0081 15.9 0.0 0.32 10.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EEA18888.1 - 0.011 14.8 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_assoc_2 PF16193.5 EEA18888.1 - 0.015 15.6 0.0 0.043 14.2 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain AAA_11 PF13086.6 EEA18888.1 - 0.017 15.0 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA18888.1 - 0.017 15.4 0.1 0.062 13.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA18888.1 - 0.052 13.5 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 NTPase TniB PF05621.11 EEA18888.1 - 0.057 12.8 0.0 2.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 EEA18888.1 - 0.078 12.5 0.0 0.36 10.4 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.6 EEA18888.1 - 0.1 12.3 0.0 0.3 10.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 EEA18888.1 - 0.11 11.9 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DEAD PF00270.29 EEA18888.1 - 0.13 12.1 0.1 5 6.9 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase Suc_Fer-like PF06999.12 EEA18889.1 - 2.1e-58 197.4 0.0 2.4e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like CPBP PF02517.16 EEA18890.1 - 6.2e-17 61.8 6.0 6.2e-17 61.8 6.0 2.9 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease FH2 PF02181.23 EEA18892.1 - 5.6e-87 292.3 7.1 5.6e-87 292.3 7.1 2.6 2 1 2 4 4 4 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EEA18892.1 - 1.3e-66 223.8 1.1 2.7e-66 222.7 0.0 2.2 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EEA18892.1 - 1.7e-51 174.6 3.9 3e-50 170.6 0.0 3.0 2 1 1 3 3 3 2 Diaphanous FH3 Domain TssO PF17561.2 EEA18892.1 - 1.2 9.2 9.3 0.071 13.2 1.3 2.8 2 0 0 2 2 2 0 Type VI secretion system, TssO Myb_DNA-binding PF00249.31 EEA18894.1 - 1.9e-32 111.2 6.2 7.6e-12 45.2 0.1 3.3 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA18894.1 - 1.7e-30 105.1 1.6 1.6e-12 47.5 0.1 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA18894.1 - 0.00043 20.1 0.2 0.023 14.6 0.1 2.9 2 1 1 3 3 3 1 Myb DNA-binding like SLIDE PF09111.10 EEA18894.1 - 0.051 13.6 0.5 3.9 7.5 0.0 3.4 3 1 1 4 4 4 0 SLIDE SANT_DAMP1_like PF16282.5 EEA18894.1 - 0.052 13.8 0.6 0.42 10.8 0.1 2.2 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 MADF_DNA_bdg PF10545.9 EEA18894.1 - 0.15 12.4 3.6 16 5.9 0.1 3.1 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Aconitase PF00330.20 EEA18895.1 - 6.5e-112 374.9 0.4 6.5e-111 371.6 0.4 2.2 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EEA18895.1 - 1.6e-25 89.9 0.0 2.9e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain MCM PF00493.23 EEA18895.1 - 0.23 10.5 0.4 0.38 9.8 0.4 1.3 1 0 0 1 1 1 0 MCM P-loop domain FAD_binding_6 PF00970.24 EEA18896.1 - 2.8e-08 34.0 0.0 7e-08 32.7 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EEA18896.1 - 3.4e-07 30.9 0.0 0.00068 20.3 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EEA18896.1 - 0.0093 16.1 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain AA_permease_2 PF13520.6 EEA18897.1 - 2e-61 208.1 45.7 2.6e-61 207.8 45.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA18897.1 - 2.4e-24 85.8 28.1 2.4e-24 85.8 28.1 2.1 2 0 0 2 2 2 1 Amino acid permease tRNA-synt_1 PF00133.22 EEA18898.1 - 1.2e-54 185.7 0.0 4.6e-35 121.0 0.0 6.2 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EEA18898.1 - 3.5e-41 140.8 0.0 5.3e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EEA18898.1 - 1.4e-28 99.8 0.2 2.5e-21 75.9 0.0 4.5 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EEA18898.1 - 5.4e-12 45.9 0.0 1.1e-11 44.9 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1d PF00750.19 EEA18898.1 - 0.0084 15.1 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) tRNA-synt_1e PF01406.19 EEA18898.1 - 0.049 13.0 0.0 2.5 7.3 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Glyco_hydro_11 PF00457.17 EEA18899.1 - 1.1e-63 214.0 16.9 1.4e-63 213.7 16.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 BetaGal_dom4_5 PF13364.6 EEA18900.1 - 0.033 14.8 0.0 0.047 14.2 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain MnmE_helical PF12631.7 EEA18901.1 - 3.1e-33 115.7 1.8 1.7e-24 87.1 1.0 2.4 2 0 0 2 2 2 2 MnmE helical domain TrmE_N PF10396.9 EEA18901.1 - 2.3e-21 76.3 0.0 6e-21 74.9 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EEA18901.1 - 1.5e-17 63.7 0.0 2.9e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA18901.1 - 1.3e-07 31.4 0.1 1.5e-05 24.7 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Glyco_hydro_3_C PF01915.22 EEA18901.1 - 2.7e-05 24.2 0.8 0.0001 22.4 0.2 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain FeoB_N PF02421.18 EEA18901.1 - 3e-05 23.6 0.1 0.00016 21.3 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA18901.1 - 4.9e-05 23.4 0.2 0.00019 21.5 0.0 2.1 2 0 0 2 2 2 1 Dynamin family AAA_24 PF13479.6 EEA18901.1 - 0.00034 20.4 0.0 0.0028 17.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain Colicin PF01024.19 EEA18901.1 - 0.043 13.7 0.0 0.14 12.0 0.0 1.7 2 0 0 2 2 2 0 Colicin pore forming domain Roc PF08477.13 EEA18901.1 - 0.047 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EEA18901.1 - 0.095 12.0 0.0 0.21 10.9 0.0 1.7 1 0 0 1 1 1 0 AIG1 family RsgA_GTPase PF03193.16 EEA18901.1 - 0.1 12.5 0.1 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase 2-Hacid_dh_C PF02826.19 EEA18902.1 - 1e-49 168.3 0.0 1.6e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA18902.1 - 1.4e-15 57.1 0.0 2.1e-15 56.5 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA18902.1 - 0.0026 17.9 0.0 0.0074 16.5 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EEA18902.1 - 0.031 13.6 0.2 0.55 9.5 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PROCN PF08083.11 EEA18902.1 - 0.033 12.9 0.0 0.047 12.4 0.0 1.1 1 0 0 1 1 1 0 PROCN (NUC071) domain 2-Hacid_dh_C PF02826.19 EEA18903.1 - 7.7e-50 168.7 0.0 1.2e-49 168.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA18903.1 - 1e-15 57.6 0.0 1.4e-15 57.1 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA18903.1 - 0.002 18.3 0.0 0.006 16.8 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EEA18903.1 - 0.023 14.0 0.2 0.45 9.8 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PROCN PF08083.11 EEA18903.1 - 0.027 13.2 0.0 0.038 12.7 0.0 1.1 1 0 0 1 1 1 0 PROCN (NUC071) domain SET PF00856.28 EEA18904.1 - 5.8e-12 46.3 0.1 1.8e-11 44.7 0.1 1.8 1 1 0 1 1 1 1 SET domain TPR_12 PF13424.6 EEA18904.1 - 0.12 12.7 0.4 0.7 10.2 0.1 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat OmdA PF13376.6 EEA18904.1 - 0.13 12.2 0.0 0.46 10.5 0.0 1.9 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated DoxX_3 PF13781.6 EEA18905.1 - 0.021 15.4 0.9 0.021 15.4 0.9 2.8 2 1 1 3 3 3 0 DoxX-like family PIRT PF15099.6 EEA18905.1 - 0.43 10.2 4.1 0.22 11.1 1.0 2.2 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family DUF3262 PF11660.8 EEA18905.1 - 4 7.9 10.4 5 7.6 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) MBOAT PF03062.19 EEA18906.1 - 5.1e-53 180.6 5.6 5.1e-53 180.6 5.6 1.8 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF983 PF06170.12 EEA18906.1 - 0.045 14.2 0.9 0.045 14.2 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF983) MBOAT PF03062.19 EEA18907.1 - 1.5e-53 182.4 5.7 3.4e-53 181.2 5.7 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF983 PF06170.12 EEA18907.1 - 0.034 14.5 0.9 0.034 14.5 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Sec1 PF00995.23 EEA18908.1 - 1.5e-135 453.7 0.1 1.8e-135 453.4 0.1 1.0 1 0 0 1 1 1 1 Sec1 family Glyco_hydro_18 PF00704.28 EEA18909.1 - 2.3e-16 60.5 0.0 3.1e-15 56.7 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 EEA18909.1 - 2.8e-10 40.0 10.5 2.8e-10 40.0 10.5 2.6 2 1 0 2 2 2 1 Carbohydrate binding domain (family 19) Mucin PF01456.17 EEA18909.1 - 3.2 7.7 35.6 6.1 6.8 35.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Gti1_Pac2 PF09729.9 EEA18910.1 - 1.4e-63 214.3 0.0 2.5e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 Gti1/Pac2 family adh_short PF00106.25 EEA18911.1 - 1e-32 113.2 0.0 1.3e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA18911.1 - 7e-23 81.4 0.0 9e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA18911.1 - 3.3e-10 40.2 0.0 5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA18911.1 - 1.1e-05 25.0 0.1 2.1e-05 24.1 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA18911.1 - 0.0073 15.5 0.0 0.0091 15.2 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA18911.1 - 0.024 13.7 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain DapB_N PF01113.20 EEA18911.1 - 0.049 13.7 0.0 0.091 12.9 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.13 EEA18911.1 - 0.17 11.4 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family GIDA PF01134.22 EEA18912.1 - 1.1e-156 521.8 0.0 1.4e-156 521.5 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EEA18912.1 - 4.9e-68 229.4 0.1 7.9e-68 228.8 0.1 1.3 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 EEA18912.1 - 6.3e-05 22.3 2.1 0.00022 20.6 2.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA18912.1 - 8.9e-05 22.0 6.5 9.7e-05 21.9 5.8 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA18912.1 - 0.00068 19.0 0.4 0.0036 16.6 0.2 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EEA18912.1 - 0.0011 18.1 3.9 0.0014 17.7 2.5 1.9 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EEA18912.1 - 0.011 14.8 0.1 0.023 13.7 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein K_oxygenase PF13434.6 EEA18912.1 - 0.11 11.6 0.1 0.53 9.4 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EEA18912.1 - 0.12 11.0 2.0 0.41 9.3 0.8 2.3 3 0 0 3 3 3 0 HI0933-like protein NAD_binding_9 PF13454.6 EEA18912.1 - 0.15 12.1 0.2 0.72 9.8 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 EEA18912.1 - 0.51 9.9 3.5 11 5.5 0.0 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase ARD PF03079.14 EEA18913.1 - 2.1e-45 154.7 0.2 2.5e-45 154.5 0.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EEA18913.1 - 6.5e-09 35.4 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EEA18913.1 - 0.00012 22.0 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain ARD PF03079.14 EEA18914.1 - 2.1e-45 154.7 0.2 2.5e-45 154.5 0.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EEA18914.1 - 6.5e-09 35.4 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EEA18914.1 - 0.00012 22.0 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Tyr-DNA_phospho PF06087.12 EEA18915.1 - 9.2e-102 341.1 0.0 1.2e-101 340.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EEA18915.1 - 0.0001 22.2 0.0 0.0029 17.5 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain UIM PF02809.20 EEA18915.1 - 0.00034 20.3 2.1 0.00034 20.3 2.1 3.1 3 0 0 3 3 3 1 Ubiquitin interaction motif RAP80_UIM PF18282.1 EEA18915.1 - 0.076 12.8 0.1 1.9 8.3 0.1 2.6 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif QWRF PF04484.12 EEA18915.1 - 0.36 10.5 3.6 0.66 9.7 3.6 1.4 1 0 0 1 1 1 0 QWRF family Tyr-DNA_phospho PF06087.12 EEA18916.1 - 2.8e-88 296.7 0.0 3.4e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase UIM PF02809.20 EEA18916.1 - 0.00029 20.5 2.1 0.00029 20.5 2.1 3.2 3 0 0 3 3 3 1 Ubiquitin interaction motif PLDc_2 PF13091.6 EEA18916.1 - 0.00031 20.6 0.0 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain QWRF PF04484.12 EEA18916.1 - 0.31 10.7 3.7 0.57 9.9 3.7 1.4 1 0 0 1 1 1 0 QWRF family RAP80_UIM PF18282.1 EEA18916.1 - 0.46 10.3 3.1 1.6 8.5 0.1 2.6 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif CDP-OH_P_transf PF01066.21 EEA18917.1 - 1.7e-14 54.3 0.7 1.7e-14 54.3 0.7 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ABC2_membrane PF01061.24 EEA18918.1 - 3.8e-81 271.5 55.0 4.4e-42 143.9 17.9 3.4 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 EEA18918.1 - 4e-36 124.5 0.1 2.9e-18 66.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EEA18918.1 - 2.1e-28 98.0 3.1 2.3e-24 85.1 0.0 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EEA18918.1 - 9e-15 55.1 0.4 2.4e-14 53.7 0.4 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EEA18918.1 - 1.6e-05 24.9 0.1 0.0011 18.9 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EEA18918.1 - 2.9e-05 24.6 0.0 0.00054 20.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA18918.1 - 3.7e-05 24.2 0.1 0.0087 16.5 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.19 EEA18918.1 - 7.9e-05 22.3 0.1 0.0036 16.9 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 EEA18918.1 - 9.2e-05 22.4 0.1 0.042 13.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 EEA18918.1 - 0.00012 22.2 0.0 0.0035 17.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EEA18918.1 - 0.0002 21.4 0.1 0.099 12.7 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EEA18918.1 - 0.00028 21.2 0.2 0.067 13.5 0.0 3.5 4 1 0 4 4 3 1 AAA domain AAA_24 PF13479.6 EEA18918.1 - 0.001 18.8 0.0 0.16 11.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EEA18918.1 - 0.0013 19.0 0.2 0.0036 17.6 0.1 1.8 2 0 0 2 2 1 1 AAA domain AAA_29 PF13555.6 EEA18918.1 - 0.0027 17.4 0.7 0.53 10.1 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EEA18918.1 - 0.0042 17.0 0.2 0.26 11.2 0.2 2.5 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 EEA18918.1 - 0.0077 15.8 1.5 0.47 10.0 0.2 3.2 4 0 0 4 4 3 1 AAA domain AAA PF00004.29 EEA18918.1 - 0.019 15.4 0.1 12 6.4 0.1 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 EEA18918.1 - 0.02 14.3 0.5 0.16 11.4 0.1 2.5 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_17 PF13207.6 EEA18918.1 - 0.039 14.4 1.8 0.87 10.0 0.1 2.9 3 0 0 3 3 2 0 AAA domain Septin PF00735.18 EEA18918.1 - 0.041 13.2 0.1 0.54 9.5 0.1 2.2 2 0 0 2 2 2 0 Septin TsaE PF02367.17 EEA18918.1 - 0.061 13.3 0.4 0.66 10.0 0.3 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EEA18918.1 - 0.11 11.6 1.7 4 6.5 0.2 3.0 4 0 0 4 4 4 0 NB-ARC domain AAA_30 PF13604.6 EEA18918.1 - 0.15 11.7 2.3 3.5 7.3 0.5 2.6 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EEA18918.1 - 0.17 11.2 0.7 6.9 5.9 0.2 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EEA18918.1 - 0.25 10.6 0.8 1.2 8.3 0.5 2.1 2 0 0 2 2 2 0 Zeta toxin MMM1 PF10296.9 EEA18919.1 - 6.5e-136 452.7 0.0 7.7e-136 452.5 0.0 1.0 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 SARAF PF06682.12 EEA18920.1 - 4.6e-96 322.3 0.1 6.3e-96 321.9 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis RCR PF12273.8 EEA18920.1 - 0.0038 17.9 1.2 0.0088 16.7 1.2 1.6 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF4719 PF15843.5 EEA18920.1 - 0.24 11.5 3.9 0.23 11.6 3.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4719) CYSTM PF12734.7 EEA18920.1 - 2.2 8.6 5.3 0.9 9.9 2.1 2.0 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance Fungus-induced PF10917.8 EEA18920.1 - 9.2 6.7 16.4 46 4.4 16.4 2.2 1 1 0 1 1 1 0 Fungus-induced protein Myb_DNA-bind_7 PF15963.5 EEA18921.1 - 6.7e-29 99.6 0.1 6.7e-29 99.6 0.1 2.1 3 0 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EEA18921.1 - 1.7e-08 34.5 0.0 3.7e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA18921.1 - 0.019 15.2 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain BRE1 PF08647.11 EEA18922.1 - 5.9e-27 93.6 13.4 5.9e-27 93.6 13.4 6.9 5 1 2 7 7 6 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EEA18922.1 - 3e-09 36.6 8.2 5.5e-09 35.8 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA18922.1 - 1.4e-08 34.4 7.4 2.7e-08 33.6 7.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EEA18922.1 - 3.2e-08 33.3 8.4 5.7e-08 32.5 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA18922.1 - 5.4e-08 32.7 5.8 1.2e-07 31.6 5.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA18922.1 - 2.6e-07 30.4 10.3 4.8e-07 29.5 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA18922.1 - 1.7e-06 28.2 8.9 3e-06 27.4 8.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EEA18922.1 - 4.2e-06 26.6 11.3 7.4e-06 25.8 11.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain DUF2935 PF11155.8 EEA18922.1 - 0.00037 20.8 0.1 1.1 9.6 0.0 4.4 1 1 1 2 2 2 1 Domain of unknown function (DUF2935) zf-C3HC4_4 PF15227.6 EEA18922.1 - 0.0028 17.8 6.6 0.0053 16.9 6.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING HALZ PF02183.18 EEA18922.1 - 0.027 14.7 22.8 3.1 8.1 0.4 7.5 7 0 0 7 7 7 0 Homeobox associated leucine zipper Trimer_CC PF08954.11 EEA18922.1 - 0.03 13.9 0.2 0.03 13.9 0.2 3.8 3 0 0 3 3 3 0 Trimerisation motif zf-rbx1 PF12678.7 EEA18922.1 - 0.044 14.1 7.5 0.09 13.1 5.9 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain DUF1272 PF06906.11 EEA18922.1 - 0.069 13.3 5.7 0.15 12.2 5.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_4 PF14570.6 EEA18922.1 - 0.19 11.6 8.1 1.5 8.7 8.8 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-H2C2_2 PF13465.6 EEA18922.1 - 0.43 11.1 1.9 3.9 8.1 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double domain zf-UDP PF14569.6 EEA18922.1 - 0.52 10.5 5.1 1.3 9.2 5.1 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_10 PF16685.5 EEA18922.1 - 0.54 10.4 9.8 0.38 10.9 7.0 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-C2H2_jaz PF12171.8 EEA18922.1 - 0.76 10.1 9.7 15 6.0 0.3 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FYVE PF01363.21 EEA18922.1 - 1.6 8.9 12.4 45 4.3 12.1 2.7 1 1 1 2 2 2 0 FYVE zinc finger DUF4407 PF14362.6 EEA18922.1 - 9.1 5.5 66.6 0.33 10.2 10.1 4.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) UreF PF01730.16 EEA18923.1 - 2.8e-24 86.2 0.6 7.6e-24 84.8 0.6 1.6 1 1 0 1 1 1 1 UreF Med9 PF07544.13 EEA18923.1 - 0.14 12.2 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF826 PF05696.11 EEA18923.1 - 0.16 12.1 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF826) ABC1 PF03109.16 EEA18924.1 - 8.9e-35 119.4 0.0 2.8e-34 117.8 0.0 1.9 2 0 0 2 2 2 1 ABC1 family Pkinase PF00069.25 EEA18924.1 - 0.042 13.2 0.0 0.32 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain AMPK1_CBM PF16561.5 EEA18925.1 - 3.9e-29 100.7 0.2 6.9e-29 99.9 0.2 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EEA18925.1 - 1.1e-24 86.4 1.0 4.1e-24 84.6 1.0 2.0 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain UIM PF02809.20 EEA18925.1 - 1.9 8.6 5.6 5.6 7.1 0.1 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif Peptidase_M22 PF00814.25 EEA18927.1 - 7.1e-83 278.4 0.0 1.1e-82 277.8 0.0 1.3 1 1 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EEA18927.1 - 0.097 12.3 0.1 0.77 9.3 0.0 2.0 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus SET PF00856.28 EEA18928.1 - 1.6e-21 77.4 0.0 4.1e-21 76.1 0.0 1.7 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EEA18928.1 - 8.3e-15 55.6 3.4 2.1e-14 54.4 1.6 2.2 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding EPL1 PF10513.9 EEA18929.1 - 1.6e-21 77.3 0.3 1.6e-21 77.3 0.3 3.0 2 1 1 3 3 3 1 Enhancer of polycomb-like Med15 PF09606.10 EEA18929.1 - 3.2 6.3 16.5 6.4 5.3 16.5 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal EF-hand_1 PF00036.32 EEA18930.1 - 7.9e-28 93.9 11.2 2.7e-08 32.8 0.9 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA18930.1 - 8.2e-23 80.6 6.0 1.2e-13 51.3 1.7 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA18930.1 - 6.2e-21 72.5 5.9 0.00012 21.8 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EEA18930.1 - 6.2e-19 66.6 9.7 5.6e-07 28.8 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EEA18930.1 - 3.3e-13 49.3 11.3 9.8e-05 22.1 0.5 4.4 3 1 2 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EEA18930.1 - 2.1e-06 28.0 0.0 0.0028 17.9 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EEA18930.1 - 0.00011 22.1 8.6 0.15 12.0 0.5 4.0 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EEA18930.1 - 0.049 14.0 0.1 0.84 10.0 0.1 2.6 2 1 1 3 3 3 0 EF-hand domain Glyco_hydro_cc PF11790.8 EEA18931.1 - 1.6e-62 211.2 0.3 2.2e-62 210.8 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF4667 PF15700.5 EEA18931.1 - 0.00036 20.7 6.6 0.0005 20.2 6.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) DUF4050 PF13259.6 EEA18931.1 - 0.016 15.5 3.3 0.026 14.8 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Apt1 PF10351.9 EEA18931.1 - 0.024 13.5 4.8 0.031 13.2 4.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 EEA18931.1 - 0.042 13.8 3.8 0.05 13.5 3.8 1.2 1 0 0 1 1 1 0 SPX domain CCDC24 PF15669.5 EEA18931.1 - 0.33 10.8 7.8 0.65 9.8 7.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family BUD22 PF09073.10 EEA18931.1 - 0.35 10.1 4.3 0.47 9.7 4.3 1.1 1 0 0 1 1 1 0 BUD22 DUF4614 PF15391.6 EEA18931.1 - 0.87 9.6 20.5 1.5 8.8 20.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Secretin_N_2 PF07655.13 EEA18931.1 - 0.92 10.1 25.9 3.2 8.4 25.9 1.9 1 0 0 1 1 1 0 Secretin N-terminal domain AF-4 PF05110.13 EEA18931.1 - 1 7.4 26.1 1.3 7.0 26.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RAP1 PF07218.11 EEA18931.1 - 2.3 6.4 17.6 2.8 6.1 17.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1635 PF07795.11 EEA18931.1 - 4.1 7.2 8.1 7 6.4 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Macoilin PF09726.9 EEA18931.1 - 4.6 5.7 12.3 6 5.3 12.3 1.1 1 0 0 1 1 1 0 Macoilin family Fungal_trans PF04082.18 EEA18932.1 - 3.1e-10 39.6 0.3 4.8e-10 38.9 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA18932.1 - 5.5e-10 39.2 8.0 1.1e-09 38.2 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phage_Cox PF10743.9 EEA18932.1 - 0.18 11.9 0.0 0.44 10.7 0.0 1.6 1 0 0 1 1 1 0 Regulatory phage protein cox ADH_zinc_N_2 PF13602.6 EEA18933.1 - 1.2e-17 65.2 0.0 2.3e-17 64.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EEA18933.1 - 2.3e-11 43.8 0.0 5.1e-10 39.4 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA18933.1 - 1.4e-06 28.2 0.0 3.9e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DapB_N PF01113.20 EEA18933.1 - 0.0028 17.8 0.0 0.0068 16.5 0.0 1.6 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 EEA18933.1 - 0.072 13.0 0.2 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 EEA18933.1 - 0.093 12.2 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase AlaDh_PNT_C PF01262.21 EEA18933.1 - 0.1 11.9 0.4 0.2 10.9 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RmlD_sub_bind PF04321.17 EEA18933.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain KR PF08659.10 EEA18933.1 - 0.11 12.3 0.6 0.19 11.6 0.1 1.6 2 0 0 2 2 2 0 KR domain Epimerase PF01370.21 EEA18933.1 - 0.12 11.9 0.2 0.17 11.3 0.2 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Leucyl-specific PF14795.6 EEA18934.1 - 0.076 13.1 0.0 0.42 10.7 0.0 2.0 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain Ribosomal_S9 PF00380.19 EEA18935.1 - 4.7e-40 136.9 0.2 8.8e-40 136.0 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 EF1G PF00647.19 EEA18936.1 - 2e-44 150.0 0.1 3.9e-44 149.1 0.1 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EEA18936.1 - 1.1e-14 54.4 0.0 3.1e-14 53.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA18936.1 - 1.2e-09 38.4 0.0 3.7e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA18936.1 - 9.2e-07 28.8 0.4 2.8e-06 27.3 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA18936.1 - 0.0003 21.1 0.0 0.0008 19.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA18936.1 - 0.0013 18.9 0.0 0.0028 17.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain NIF PF03031.18 EEA18937.1 - 2.1e-24 86.1 5.4 2.5e-24 85.8 2.2 2.6 2 1 0 2 2 2 1 NLI interacting factor-like phosphatase DUF705 PF05152.12 EEA18937.1 - 0.011 15.2 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF705) HAD_SAK_2 PF18143.1 EEA18937.1 - 0.029 14.7 0.8 0.1 12.9 0.2 2.3 2 1 0 2 2 2 0 HAD domain in Swiss Army Knife RNA repair proteins RRP36 PF06102.12 EEA18938.1 - 2.3e-49 167.6 32.5 2.3e-49 167.6 32.5 2.9 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 DUF2229 PF09989.9 EEA18938.1 - 0.015 15.0 2.6 0.031 13.9 2.6 1.6 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF659 PF04937.15 EEA18939.1 - 5e-10 39.4 0.5 9.7e-10 38.5 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Dimer_Tnp_hAT PF05699.14 EEA18939.1 - 5.2e-06 26.2 0.4 2.2e-05 24.1 0.1 2.2 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF2110 PF09883.9 EEA18939.1 - 0.15 11.6 0.1 0.26 10.8 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) APG6_N PF17675.1 EEA18939.1 - 0.38 11.3 6.2 1.2 9.7 6.2 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region RNA_pol_L_2 PF13656.6 EEA18940.1 - 1.1e-33 114.8 0.0 1.5e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EEA18940.1 - 1.4e-14 53.3 0.0 1.9e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF859 PF05895.12 EEA18940.1 - 0.062 11.8 0.0 0.065 11.7 0.0 1.1 1 0 0 1 1 1 0 Siphovirus protein of unknown function (DUF859) RNA_pol_L_2 PF13656.6 EEA18941.1 - 4.8e-25 87.1 0.0 7e-25 86.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EEA18941.1 - 6.1e-10 38.4 0.0 8.4e-10 38.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_LYR_2 PF13233.6 EEA18942.1 - 1.5e-05 25.6 0.6 2.1e-05 25.2 0.6 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EEA18942.1 - 0.00021 21.3 0.4 0.00045 20.2 0.4 1.6 1 1 0 1 1 1 1 Complex 1 protein (LYR family) RRM_Rrp7 PF17799.1 EEA18942.1 - 0.033 14.0 0.0 0.039 13.7 0.0 1.1 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain IKKbetaNEMObind PF12179.8 EEA18942.1 - 0.11 12.6 0.0 0.58 10.2 0.0 2.0 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain Abhydrolase_1 PF00561.20 EEA18944.1 - 4.9e-10 39.5 0.1 1.1e-09 38.3 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA18944.1 - 5.3e-05 22.6 0.0 0.00018 20.9 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 MNHE PF01899.16 EEA18947.1 - 0.0094 15.7 7.3 0.013 15.2 7.3 1.4 1 1 0 1 1 1 1 Na+/H+ ion antiporter subunit Cas_Cas2CT1978 PF09707.10 EEA18947.1 - 0.013 15.6 0.8 0.033 14.3 0.8 1.7 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) ARL6IP6 PF15062.6 EEA18947.1 - 0.19 11.9 0.1 0.41 10.8 0.1 1.6 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix Cohesin_load PF10345.9 EEA18948.1 - 1.9e-165 551.7 7.7 2.4e-165 551.4 7.7 1.0 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.6 EEA18948.1 - 1.7 9.0 9.4 27 5.1 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Histone PF00125.24 EEA18949.1 - 4e-42 143.7 0.2 4e-42 143.7 0.2 2.1 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EEA18949.1 - 0.00035 20.6 0.0 0.00075 19.6 0.0 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EEA18949.1 - 0.0016 18.8 0.1 0.003 17.9 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EEA18949.1 - 0.06 13.6 0.5 0.14 12.4 0.5 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone adh_short PF00106.25 EEA18950.1 - 7.5e-37 126.7 0.1 8.8e-37 126.5 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA18950.1 - 1.8e-27 96.4 0.1 2.5e-27 96.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA18950.1 - 2e-12 47.4 0.0 2.6e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA18950.1 - 0.0017 17.9 0.1 0.016 14.7 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family QRPTase_C PF01729.19 EEA18950.1 - 0.17 11.6 0.3 0.66 9.7 0.3 1.9 1 1 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain LRR_6 PF13516.6 EEA18952.1 - 0.011 15.7 4.7 31 5.0 0.0 6.7 8 0 0 8 8 8 0 Leucine Rich repeat LRR_1 PF00560.33 EEA18952.1 - 0.028 14.9 0.8 2.2e+02 3.1 0.0 6.6 6 0 0 6 6 6 0 Leucine Rich Repeat IGPD PF00475.18 EEA18954.1 - 3.5e-56 189.5 0.4 5.9e-56 188.8 0.5 1.4 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase Arena_RNA_pol PF06317.11 EEA18954.1 - 0.2 8.8 0.0 0.25 8.5 0.0 1.0 1 0 0 1 1 1 0 Arenavirus RNA polymerase Gly_transf_sug PF04488.15 EEA18956.1 - 4.8e-22 78.4 0.0 9.1e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif SCIMP PF15050.6 EEA18956.1 - 0.13 12.7 2.4 0.25 11.8 2.4 1.4 1 0 0 1 1 1 0 SCIMP protein TcdA_TcdB PF12919.7 EEA18956.1 - 0.37 10.0 1.6 0.7 9.1 0.3 1.8 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain DER1 PF04511.15 EEA18957.1 - 4.9e-49 166.9 2.8 5.8e-49 166.6 2.8 1.0 1 0 0 1 1 1 1 Der1-like family Pet127 PF08634.10 EEA18958.1 - 5.9e-122 406.4 0.9 9.4e-122 405.7 0.9 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 GARS_A PF01071.19 EEA18959.1 - 9.9e-84 279.9 0.0 2.4e-83 278.7 0.0 1.6 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EEA18959.1 - 6.8e-35 119.7 0.0 2.3e-34 118.0 0.0 2.0 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EEA18959.1 - 1e-29 103.6 0.0 3.2e-29 102.1 0.0 1.8 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EEA18959.1 - 3.1e-26 91.5 0.4 8.5e-26 90.1 0.4 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EEA18959.1 - 2.7e-14 53.6 3.2 6.7e-14 52.3 2.5 2.1 2 0 0 2 2 1 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 EEA18959.1 - 0.00015 21.4 0.0 0.00025 20.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EEA18959.1 - 0.00047 20.2 0.0 0.0017 18.4 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EEA18959.1 - 0.00062 19.3 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 EEA18959.1 - 0.018 14.6 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_ST PF14397.6 EEA18959.1 - 0.1 11.8 0.0 0.4 9.9 0.0 1.8 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATP-grasp_2 PF08442.10 EEA18959.1 - 0.15 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Actin PF00022.19 EEA18960.1 - 1.7e-150 501.2 0.0 6.1e-150 499.3 0.0 1.7 1 1 0 1 1 1 1 Actin Actin PF00022.19 EEA18961.1 - 1.7e-150 501.2 0.0 6.1e-150 499.3 0.0 1.7 1 1 0 1 1 1 1 Actin Fes1 PF08609.10 EEA18963.1 - 1.8e-29 102.4 4.0 3.3e-29 101.6 3.0 1.9 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_EZ PF13513.6 EEA18963.1 - 4.1e-09 36.7 0.5 7.9e-08 32.6 0.1 2.5 2 0 0 2 2 2 1 HEAT-like repeat HEAT PF02985.22 EEA18963.1 - 2.1e-08 33.7 0.1 0.0011 19.0 0.0 3.0 3 0 0 3 3 3 2 HEAT repeat Arm PF00514.23 EEA18963.1 - 2.1e-07 30.7 0.1 0.0097 15.9 0.0 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EEA18963.1 - 4.7e-07 30.1 0.2 1.3e-06 28.7 0.0 1.9 2 0 0 2 2 2 1 HEAT repeats V-ATPase_H_C PF11698.8 EEA18963.1 - 0.024 14.7 0.0 0.77 9.9 0.0 1.9 1 1 1 2 2 2 0 V-ATPase subunit H V-ATPase_H_N PF03224.14 EEA18963.1 - 0.071 12.4 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit H AIRC PF00731.20 EEA18963.1 - 0.12 12.0 0.0 0.55 9.8 0.0 2.0 1 1 0 1 1 1 0 AIR carboxylase Tospo_nucleocap PF01533.16 EEA18963.1 - 0.14 11.6 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein UPF0220 PF05255.11 EEA18964.1 - 5.6e-72 240.7 2.7 6.3e-72 240.5 2.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) ATP1G1_PLM_MAT8 PF02038.16 EEA18964.1 - 0.17 11.4 0.5 0.48 9.9 0.0 2.0 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Proteasome PF00227.26 EEA18965.1 - 1.5e-48 164.8 0.1 2e-48 164.4 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA18965.1 - 3e-12 46.0 0.3 5e-12 45.3 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Proteasome PF00227.26 EEA18966.1 - 3.5e-37 127.7 0.0 4.7e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Lysine_decarbox PF03641.14 EEA18967.1 - 6.4e-27 94.2 0.1 1.5e-26 93.1 0.1 1.6 1 1 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EEA18967.1 - 0.0055 16.3 1.0 0.051 13.2 0.1 2.2 2 0 0 2 2 2 1 SLOG cluster4 family DAGK_cat PF00781.24 EEA18967.1 - 0.21 11.2 1.7 2.9 7.5 0.2 2.4 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain Med6 PF04934.14 EEA18968.1 - 3.5e-38 130.4 0.1 5.8e-38 129.7 0.1 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component Vps55 PF04133.14 EEA18969.1 - 1.1e-43 147.9 7.3 1.2e-43 147.7 7.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Sld7_C PF18596.1 EEA18970.1 - 4.2e-14 52.4 0.0 8.4e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 Sld7 C-terminal domain Glyco_hydro_43 PF04616.14 EEA18971.1 - 4.2e-16 59.1 0.0 5.5e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Cellulase PF00150.18 EEA18972.1 - 2.4e-16 60.0 0.5 3.6e-16 59.4 0.5 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 EEA18972.1 - 1.4e-11 44.1 5.8 1.4e-11 44.1 5.8 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain DUF4038 PF13204.6 EEA18972.1 - 1.2e-06 28.4 0.3 2.2e-06 27.5 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Glyco_hydro_2_C PF02836.17 EEA18972.1 - 0.00016 20.9 0.1 0.0008 18.6 0.0 2.2 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 EEA18972.1 - 0.009 15.4 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 1 Beta-galactosidase MFS_1 PF07690.16 EEA18973.1 - 2.2e-31 109.1 28.1 2.2e-31 109.1 28.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily T2SSI PF02501.17 EEA18974.1 - 0.0001 22.4 0.0 30 4.8 0.0 6.1 2 2 4 6 6 6 1 Type II secretion system (T2SS), protein I HAD_SAK_1 PF10307.9 EEA18975.1 - 9.1e-79 264.0 0.0 1.5e-78 263.3 0.0 1.3 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins UDPGP PF01704.18 EEA18975.1 - 0.13 10.9 0.1 0.19 10.3 0.1 1.2 1 0 0 1 1 1 0 UTP--glucose-1-phosphate uridylyltransferase Ins_allergen_rp PF06757.13 EEA18975.1 - 0.14 12.1 0.3 0.5 10.3 0.2 1.8 1 1 1 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification zf-RING_2 PF13639.6 EEA18976.1 - 2.5e-09 37.3 4.4 4.1e-09 36.6 4.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA18976.1 - 4.5e-07 29.6 4.6 7e-07 29.0 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA18976.1 - 4.9e-07 29.5 2.9 7.6e-07 28.9 2.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA18976.1 - 7e-07 29.0 1.8 1e-06 28.5 1.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA18976.1 - 1.7e-06 28.2 2.5 4.1e-06 27.0 2.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EEA18976.1 - 0.02 14.7 3.3 0.036 13.9 3.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EEA18976.1 - 0.15 11.8 1.8 0.32 10.8 1.8 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 EEA18976.1 - 0.16 12.1 0.3 0.4 10.8 0.2 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EEA18976.1 - 0.18 11.8 1.4 0.38 10.8 1.4 1.6 1 1 0 1 1 1 0 zinc-RING finger domain MAM33 PF02330.16 EEA18977.1 - 1.6e-71 240.7 1.3 1.9e-71 240.4 1.3 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein Thymosin PF01290.20 EEA18977.1 - 0.062 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Thymosin beta-4 family Tma16 PF11176.8 EEA18978.1 - 2.4e-49 166.9 6.1 3e-49 166.6 6.1 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 MmgE_PrpD PF03972.14 EEA18978.1 - 0.0031 16.1 0.4 0.0041 15.7 0.4 1.1 1 0 0 1 1 1 1 MmgE/PrpD family HTH_32 PF13565.6 EEA18978.1 - 0.041 14.5 1.9 0.041 14.5 1.9 2.1 2 0 0 2 2 2 0 Homeodomain-like domain FBA_2 PF07735.17 EEA18978.1 - 0.082 13.0 0.0 0.68 10.1 0.0 2.1 2 0 0 2 2 2 0 F-box associated XPG_I PF00867.18 EEA18979.1 - 6e-23 81.0 0.0 1.4e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EEA18979.1 - 7e-23 81.0 0.0 1.7e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EEA18979.1 - 0.00077 19.0 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing Fig1 PF12351.8 EEA18980.1 - 9.5e-57 192.0 5.2 9.5e-57 192.0 5.2 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 EEA18980.1 - 1.3e-06 28.2 6.9 1.8e-06 27.8 6.9 1.2 1 0 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.13 EEA18980.1 - 0.0014 17.7 3.4 0.0014 17.7 3.4 1.8 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF898) SAM_adeno_trans PF01887.16 EEA18980.1 - 0.041 13.3 0.1 0.057 12.9 0.1 1.1 1 0 0 1 1 1 0 S-adenosyl-l-methionine hydroxide adenosyltransferase DUF751 PF05421.11 EEA18980.1 - 0.98 10.2 0.0 0.98 10.2 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF751) DNA_primase_S PF01896.19 EEA18981.1 - 3.5e-59 199.8 0.3 5.6e-59 199.2 0.3 1.2 1 0 0 1 1 1 1 DNA primase small subunit Mucin-like PF16058.5 EEA18982.1 - 6.7e-07 29.3 44.3 6.7e-07 29.3 44.3 3.0 2 1 1 3 3 3 1 Mucin-like Thr_synth_N PF14821.6 EEA18983.1 - 2e-29 101.6 0.0 5.8e-29 100.1 0.0 1.9 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EEA18983.1 - 1.3e-17 64.2 0.0 4.4e-17 62.4 0.0 1.8 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme BCS1_N PF08740.11 EEA18984.1 - 9.8e-33 113.7 2.2 1.1e-32 113.6 0.8 1.7 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EEA18984.1 - 7e-16 58.8 0.0 1.8e-07 31.7 0.0 2.7 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EEA18984.1 - 0.0082 16.4 0.1 0.025 14.8 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EEA18984.1 - 0.036 13.6 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA18984.1 - 0.059 13.8 0.2 0.14 12.5 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EEA18984.1 - 0.07 13.1 0.0 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EEA18984.1 - 0.1 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 KaiC TraV PF09676.10 EEA18985.1 - 0.28 12.2 0.1 0.28 12.2 0.1 2.7 1 1 1 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) LegC3_N PF18654.1 EEA18985.1 - 0.3 10.3 11.7 0.052 12.8 8.0 1.6 2 0 0 2 2 2 0 LegC3 N-terminal coiled-coil domain Zip PF02535.22 EEA18985.1 - 3.2 6.9 4.6 5.2 6.2 4.6 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Coatomer_WDAD PF04053.14 EEA18987.1 - 1.8e-143 478.8 0.2 1.2e-142 476.1 0.0 2.0 2 0 0 2 2 2 1 Coatomer WD associated region COPI_C PF06957.11 EEA18987.1 - 1.7e-106 356.4 0.1 2.5e-106 355.8 0.1 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EEA18987.1 - 1.8e-37 126.7 16.8 3.7e-07 30.7 0.3 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA18987.1 - 1e-08 35.4 0.8 0.18 12.1 0.0 5.5 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA18987.1 - 0.0034 16.1 5.7 0.62 8.6 0.1 3.5 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Clathrin PF00637.20 EEA18987.1 - 0.041 13.7 1.8 0.19 11.6 0.0 2.8 3 1 0 3 3 3 0 Region in Clathrin and VPS Evr1_Alr PF04777.13 EEA18988.1 - 6.5e-29 100.4 3.1 6.5e-29 100.4 3.1 1.5 2 0 0 2 2 2 1 Erv1 / Alr family CAP_N PF01213.19 EEA18988.1 - 0.29 10.6 1.2 0.33 10.4 1.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DEK_C PF08766.11 EEA18989.1 - 0.002 18.0 0.1 0.0073 16.2 0.1 2.0 1 0 0 1 1 1 1 DEK C terminal domain Glyco_transf_54 PF04666.13 EEA18990.1 - 2.1e-13 49.8 0.1 1.1e-10 40.9 0.0 2.8 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.17 EEA18990.1 - 0.076 12.9 0.0 0.45 10.4 0.0 2.0 2 0 0 2 2 2 0 Glycosyltransferase family 25 (LPS biosynthesis protein) CReP_N PF10472.9 EEA18990.1 - 0.18 10.6 0.0 0.28 10.0 0.0 1.2 1 0 0 1 1 1 0 eIF2-alpha phosphatase phosphorylation constitutive repressor Adaptin_N PF01602.20 EEA18991.1 - 3.9e-138 461.3 6.6 5e-138 460.9 6.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EEA18991.1 - 5.3e-64 215.1 3.6 2.3e-60 203.3 0.7 2.7 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA18991.1 - 2e-18 66.5 5.0 1e-08 35.4 0.0 6.2 2 1 5 7 7 7 5 HEAT repeats HEAT PF02985.22 EEA18991.1 - 7.5e-14 50.7 2.9 0.0047 17.1 0.0 6.6 6 0 0 6 6 6 3 HEAT repeat Arm PF00514.23 EEA18991.1 - 8.5e-05 22.5 1.3 0.43 10.7 0.0 5.3 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EEA18991.1 - 0.0019 17.8 0.0 9.4 5.7 0.0 3.7 2 1 1 3 3 3 1 CLASP N terminal HEAT_EZ PF13513.6 EEA18991.1 - 0.002 18.6 6.2 0.77 10.3 0.0 5.8 5 1 1 6 6 6 1 HEAT-like repeat RTP1_C1 PF10363.9 EEA18991.1 - 0.0054 16.9 0.3 1.1 9.4 0.0 3.8 3 2 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF2817 PF10994.8 EEA18991.1 - 0.043 13.2 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Sec7_N PF12783.7 EEA18991.1 - 0.31 10.9 2.4 1.4 8.8 0.7 3.0 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal TBCC PF07986.12 EEA18992.1 - 8.9e-34 115.8 1.5 1.4e-33 115.2 1.5 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EEA18992.1 - 3.9e-09 37.0 0.1 7e-09 36.1 0.1 1.4 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain CENP-L PF13092.6 EEA18992.1 - 0.044 14.0 0.0 0.065 13.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 F_actin_bind PF08919.10 EEA18992.1 - 0.057 13.5 0.3 0.64 10.1 0.0 2.3 1 1 1 2 2 2 0 F-actin binding Pro-kuma_activ PF09286.11 EEA18993.1 - 8.9e-35 120.1 0.1 6.2e-34 117.3 0.1 2.3 2 1 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EEA18993.1 - 5.8e-08 32.3 0.1 1e-07 31.6 0.1 1.3 1 0 0 1 1 1 1 Subtilase family Cupin_2 PF07883.11 EEA18994.1 - 8.1e-07 28.7 0.0 1.6e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EEA18994.1 - 0.00011 21.8 0.0 0.00018 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) adh_short_C2 PF13561.6 EEA18995.1 - 0.0038 16.8 0.0 0.0097 15.5 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA18995.1 - 0.0064 16.0 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase PARP PF00644.20 EEA18995.1 - 0.027 14.1 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain CSN8_PSD8_EIF3K PF10075.9 EEA18996.1 - 1.8e-18 66.9 0.0 3.4e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EEA18996.1 - 0.00019 21.0 0.0 0.00026 20.5 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP family WD40 PF00400.32 EEA18997.1 - 0.014 16.3 0.3 24 6.0 0.0 3.8 3 0 0 3 3 3 0 WD domain, G-beta repeat Vps51 PF08700.11 EEA18998.1 - 5.2e-26 90.5 0.0 1.3e-25 89.3 0.0 1.7 1 0 0 1 1 1 1 Vps51/Vps67 COG5 PF10392.9 EEA18998.1 - 0.059 13.5 0.0 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Dor1 PF04124.12 EEA18998.1 - 0.074 11.7 0.0 0.12 11.0 0.0 1.4 1 1 0 1 1 1 0 Dor1-like family RMI1_N PF08585.12 EEA18999.1 - 6.8e-65 218.9 0.1 8e-65 218.6 0.1 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein NuiA PF07924.11 EEA18999.1 - 0.049 14.0 0.1 0.094 13.1 0.1 1.4 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein TPR_2 PF07719.17 EEA19000.1 - 2.2e-27 92.9 44.7 0.021 14.9 0.1 16.0 17 0 0 17 17 16 8 Tetratricopeptide repeat TPR_19 PF14559.6 EEA19000.1 - 8.9e-25 87.0 16.9 9.8e-06 26.0 0.2 11.9 10 2 2 12 12 12 4 Tetratricopeptide repeat TPR_1 PF00515.28 EEA19000.1 - 2e-24 84.4 31.4 0.013 15.3 0.0 15.3 15 1 0 15 15 15 6 Tetratricopeptide repeat TPR_8 PF13181.6 EEA19000.1 - 3.2e-23 80.0 25.6 0.056 13.7 0.1 13.9 14 0 0 14 14 13 7 Tetratricopeptide repeat TPR_14 PF13428.6 EEA19000.1 - 5.7e-23 79.7 30.9 0.0042 17.8 0.0 16.5 13 5 5 18 18 15 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA19000.1 - 3.5e-21 75.5 48.9 4.2e-05 24.1 0.2 13.3 15 1 1 16 16 15 6 Tetratricopeptide repeat TPR_17 PF13431.6 EEA19000.1 - 1.3e-20 72.2 17.5 0.16 12.4 0.0 15.2 17 0 0 17 17 15 4 Tetratricopeptide repeat TPR_12 PF13424.6 EEA19000.1 - 1.8e-13 50.5 44.2 1.7e-05 25.0 0.2 13.6 11 2 6 17 17 16 6 Tetratricopeptide repeat TPR_7 PF13176.6 EEA19000.1 - 2.3e-13 49.2 18.1 0.0061 16.5 0.0 11.7 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA19000.1 - 3.7e-13 48.9 19.6 0.0021 17.7 0.0 8.6 9 0 0 9 9 8 4 TPR repeat ANAPC3 PF12895.7 EEA19000.1 - 5.8e-09 36.1 7.0 1.2 9.4 0.0 7.5 6 1 1 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EEA19000.1 - 9.2e-06 26.0 25.4 0.67 10.7 0.0 12.3 16 0 0 16 16 13 1 Tetratricopeptide repeat TPR_4 PF07721.14 EEA19000.1 - 1.3e-05 25.3 5.5 3.9 8.4 0.2 7.9 9 0 0 9 9 6 2 Tetratricopeptide repeat DUF2989 PF11207.8 EEA19000.1 - 0.00048 19.9 1.1 1.6 8.4 0.2 4.4 3 1 1 4 4 4 1 Protein of unknown function (DUF2989) TPR_9 PF13371.6 EEA19000.1 - 0.0019 18.3 6.3 6.3 7.0 0.0 5.9 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_22 PF18833.1 EEA19000.1 - 0.012 15.7 0.0 0.047 13.8 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EEA19000.1 - 0.017 14.7 0.5 4.9 6.8 0.0 3.1 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) Sel1 PF08238.12 EEA19000.1 - 0.022 15.4 1.6 7.3 7.4 0.3 4.1 4 0 0 4 4 2 0 Sel1 repeat TPR_10 PF13374.6 EEA19000.1 - 0.046 13.6 14.1 0.66 9.9 0.0 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF3856 PF12968.7 EEA19000.1 - 0.11 12.6 4.0 8.9 6.4 0.0 5.0 6 1 0 6 6 4 0 Domain of Unknown Function (DUF3856) TPR_20 PF14561.6 EEA19000.1 - 0.22 11.9 15.4 1 9.7 0.1 5.4 6 1 0 6 6 4 0 Tetratricopeptide repeat TerB PF05099.13 EEA19000.1 - 0.64 10.0 9.2 1.2 9.1 0.1 3.9 4 0 0 4 4 3 0 Tellurite resistance protein TerB DUF2225 PF09986.9 EEA19000.1 - 1.4 8.6 4.7 3.1 7.5 0.1 3.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Glyco_hydro_5_C PF18564.1 EEA19001.1 - 2.9e-22 79.0 0.0 8.2e-22 77.6 0.0 1.8 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EEA19001.1 - 9.7e-09 35.0 6.8 3.8e-07 29.8 4.4 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) EKLF_TAD1 PF16832.5 EEA19001.1 - 0.044 13.7 0.3 0.1 12.5 0.3 1.6 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 Fungal_trans PF04082.18 EEA19002.1 - 1.1e-06 27.9 0.3 4.9e-06 25.8 0.0 2.2 1 1 1 2 2 2 1 Fungal specific transcription factor domain T3SS_ExsE PF18286.1 EEA19002.1 - 0.091 12.7 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 Type III secretion system ExsE adh_short PF00106.25 EEA19003.1 - 3.8e-21 75.4 0.0 1.1e-16 60.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19003.1 - 1.5e-15 57.4 0.2 1.7e-14 54.0 0.2 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19003.1 - 0.032 14.1 0.1 0.068 13.1 0.0 1.6 2 0 0 2 2 2 0 KR domain Xpo1 PF08389.12 EEA19004.1 - 2.8e-11 43.7 6.0 3.3e-10 40.2 1.6 4.2 4 1 0 4 4 4 1 Exportin 1-like protein GRIM-19 PF06212.12 EEA19005.1 - 1.9e-22 79.6 0.2 4.4e-22 78.5 0.2 1.6 1 1 0 1 1 1 1 GRIM-19 protein tRNA_m1G_MT PF01746.21 EEA19006.1 - 4.7e-23 81.9 0.0 5.5e-22 78.4 0.0 2.3 1 1 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DUF5598 PF18127.1 EEA19006.1 - 0.2 12.1 0.5 0.54 10.7 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5598) Ndc1_Nup PF09531.10 EEA19006.1 - 1.4 7.5 5.0 1.9 7.1 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NARP1 PF12569.8 EEA19006.1 - 4.5 6.1 14.2 14 4.5 11.5 2.3 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Fungal_trans PF04082.18 EEA19007.1 - 2.9e-27 95.4 0.9 2.9e-27 95.4 0.9 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19007.1 - 5.2e-08 32.9 10.6 5.2e-08 32.9 10.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldolase_II PF00596.21 EEA19008.1 - 1.2e-46 159.1 0.0 1.4e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain 2-Hacid_dh_C PF02826.19 EEA19009.1 - 9.7e-56 187.9 0.0 1.5e-55 187.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA19009.1 - 1.3e-17 63.7 0.0 1.7e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA19009.1 - 1.4e-07 31.8 0.0 4e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EEA19009.1 - 0.017 14.7 0.0 0.039 13.5 0.0 1.6 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 EEA19009.1 - 0.019 15.6 0.0 0.038 14.6 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EEA19009.1 - 0.18 11.4 0.0 0.57 9.8 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DAO PF01266.24 EEA19010.1 - 1.2e-31 110.6 0.0 1.4e-31 110.4 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA19010.1 - 1.6e-06 28.3 0.0 3.7e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EEA19010.1 - 5.4e-05 22.6 0.0 0.00016 21.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA19010.1 - 0.00011 22.2 0.0 0.11 12.4 0.0 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EEA19010.1 - 0.00025 20.3 0.0 0.017 14.2 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain Glu_dehyd_C PF16912.5 EEA19010.1 - 0.0052 16.3 0.0 0.071 12.6 0.0 2.5 3 0 0 3 3 3 1 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 EEA19010.1 - 0.0085 15.4 0.0 0.18 11.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA19010.1 - 0.013 14.2 0.0 0.18 10.5 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 EEA19010.1 - 0.026 13.6 0.0 2.1 7.4 0.0 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EEA19010.1 - 0.047 12.9 0.0 0.077 12.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EEA19010.1 - 0.08 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 EEA19010.1 - 0.081 13.0 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 EEA19010.1 - 0.13 11.5 0.0 0.28 10.4 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Sugar_tr PF00083.24 EEA19011.1 - 1.3e-77 261.6 25.5 1.5e-77 261.4 25.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19011.1 - 3.8e-21 75.4 44.3 2.3e-17 63.0 23.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1338 PF07063.13 EEA19013.1 - 1.8e-110 369.1 0.2 2.1e-110 368.9 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) VID27 PF08553.10 EEA19014.1 - 1.9e-195 648.9 0.0 2.7e-195 648.4 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EEA19014.1 - 4.7e-78 261.0 0.3 4.7e-78 261.0 0.3 3.4 3 1 1 4 4 4 1 VID27 N-terminal region VID27_PH PF17747.1 EEA19014.1 - 1.1e-47 160.8 2.0 2.9e-47 159.5 0.8 2.1 2 0 0 2 2 2 1 VID27 PH-like domain UPF0149 PF03695.13 EEA19014.1 - 0.0033 17.8 6.4 0.013 15.8 3.8 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0149) DUF3801 PF12687.7 EEA19014.1 - 0.33 11.0 4.2 1.5 8.8 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) TLD PF07534.16 EEA19015.1 - 2.5e-26 92.6 0.1 9.3e-16 58.3 0.1 2.5 2 0 0 2 2 2 2 TLD AIM3 PF17096.5 EEA19015.1 - 0.41 11.6 15.4 0.12 13.3 4.2 2.5 2 1 0 2 2 2 0 Altered inheritance of mitochondria protein 3 JAB PF01398.21 EEA19016.1 - 4.5e-16 58.9 0.0 1.1e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 EEA19016.1 - 3e-11 43.5 0.1 5.8e-11 42.6 0.1 1.4 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 EEA19016.1 - 4.8e-05 23.1 0.1 0.00018 21.3 0.0 1.9 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain SurA_N_3 PF13624.6 EEA19016.1 - 0.51 10.1 3.3 0.46 10.3 0.5 2.0 2 0 0 2 2 2 0 SurA N-terminal domain RrnaAD PF00398.20 EEA19017.1 - 0.00035 19.7 0.0 0.00073 18.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Fez1 PF06818.15 EEA19017.1 - 0.0028 18.1 6.5 0.0035 17.8 5.6 1.6 1 1 0 1 1 1 1 Fez1 DUF5105 PF17118.5 EEA19017.1 - 0.062 13.1 1.6 1.3 8.7 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5105) TAL_effector PF03377.13 EEA19017.1 - 0.27 11.6 2.4 21 5.5 0.2 3.2 4 0 0 4 4 4 0 TAL effector repeat PAM2 PF07145.15 EEA19018.1 - 0.075 12.7 0.1 0.21 11.4 0.1 1.8 1 0 0 1 1 1 0 Ataxin-2 C-terminal region PEX-2N PF09263.10 EEA19018.1 - 0.15 12.4 0.1 0.3 11.4 0.1 1.4 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal Aldedh PF00171.22 EEA19019.1 - 2e-122 409.0 0.0 2.5e-122 408.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OmdA PF13376.6 EEA19019.1 - 0.12 12.4 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated LuxC PF05893.14 EEA19019.1 - 0.2 10.7 0.1 0.64 9.0 0.1 1.7 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) adh_short PF00106.25 EEA19020.1 - 1.1e-09 38.0 0.1 6.7e-09 35.5 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA19020.1 - 0.00015 21.7 0.0 0.00025 21.0 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EEA19020.1 - 0.0091 15.6 0.0 0.013 15.1 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Pec_lyase_C PF00544.19 EEA19021.1 - 1.5e-15 57.4 10.6 4.3e-14 52.6 10.6 2.2 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EEA19021.1 - 0.0012 18.7 14.4 0.0037 17.1 5.1 2.4 1 1 1 2 2 2 2 Right handed beta helix region Latrotoxin_C PF15658.6 EEA19021.1 - 0.088 12.6 0.1 0.23 11.2 0.1 1.8 1 0 0 1 1 1 0 Latrotoxin C-terminal domain Pkinase PF00069.25 EEA19022.1 - 2.6e-15 56.5 0.0 9.7e-15 54.6 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19022.1 - 0.0076 15.6 0.0 0.037 13.3 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA19022.1 - 0.012 14.5 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EEA19022.1 - 0.022 14.7 0.1 0.037 14.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EEA19022.1 - 0.063 12.9 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Iso_dh PF00180.20 EEA19023.1 - 2.1e-70 237.6 0.0 2.7e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HAD_2 PF13419.6 EEA19023.1 - 7.8e-17 61.9 0.0 1.3e-15 58.0 0.0 2.6 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA19023.1 - 6.6e-09 36.4 0.0 1.5e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA19023.1 - 0.0021 18.1 0.0 0.0046 17.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like FTHFS PF01268.19 EEA19024.1 - 1.4e-255 848.7 0.1 2.2e-255 848.1 0.1 1.3 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EEA19024.1 - 7.9e-67 223.6 1.4 7.9e-67 223.6 1.4 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EEA19024.1 - 5.3e-38 129.9 0.8 1.4e-37 128.5 0.6 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GTP_EFTU PF00009.27 EEA19024.1 - 0.015 14.9 0.1 0.054 13.0 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain WD40 PF00400.32 EEA19025.1 - 8.7e-27 92.8 0.3 4.9e-08 33.5 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19025.1 - 1.3e-12 47.8 0.1 0.043 14.1 0.0 5.6 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA19025.1 - 0.0015 17.3 0.0 0.03 13.0 0.0 2.0 2 0 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 EEA19025.1 - 0.014 14.7 0.0 1.4 8.2 0.0 2.7 2 1 0 2 2 2 0 WD40-like domain PALB2_WD40 PF16756.5 EEA19025.1 - 0.13 11.2 0.1 8.2 5.2 0.1 2.2 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain MBF1 PF08523.10 EEA19026.1 - 1.2e-25 89.7 1.5 1.2e-25 89.7 1.5 1.8 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EEA19026.1 - 1.2e-10 41.3 0.1 2e-10 40.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EEA19026.1 - 7.5e-05 23.0 0.1 0.00026 21.3 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain GATase_7 PF13537.6 EEA19027.1 - 2.1e-15 56.7 0.0 3.8e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EEA19027.1 - 5.1e-15 55.8 0.0 1.1e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EEA19027.1 - 9.1e-09 35.0 0.0 2.4e-08 33.6 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EEA19027.1 - 3.8e-05 22.7 0.0 7.3e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PA PF02225.22 EEA19027.1 - 0.041 13.9 0.2 0.19 11.8 0.2 2.1 1 1 0 1 1 1 0 PA domain SH3_1 PF00018.28 EEA19028.1 - 9.9e-16 57.1 0.0 1.5e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EEA19028.1 - 1.5e-13 50.4 0.0 4.9e-13 48.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EEA19028.1 - 1.7e-08 34.0 0.0 2.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EEA19029.1 - 9e-16 57.2 0.0 1.5e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EEA19029.1 - 1.3e-13 50.5 0.0 4.7e-13 48.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EEA19029.1 - 1.5e-08 34.1 0.0 2.5e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Ank_2 PF12796.7 EEA19030.1 - 5.7e-25 87.7 3.9 2.1e-16 60.3 0.4 4.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19030.1 - 8.3e-21 74.1 1.6 2.3e-06 28.1 0.1 5.4 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA19030.1 - 1.9e-14 53.4 2.3 0.017 15.6 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EEA19030.1 - 2e-14 53.5 1.6 3.6e-06 27.1 0.3 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19030.1 - 1.2e-13 49.8 5.9 0.2 12.3 0.0 7.0 8 0 0 8 8 8 4 Ankyrin repeat IRK PF01007.20 EEA19030.1 - 0.00066 19.5 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ank_2 PF12796.7 EEA19031.1 - 5.5e-25 87.8 3.9 2e-16 60.3 0.4 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19031.1 - 8.1e-21 74.1 1.6 2.2e-06 28.1 0.1 5.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA19031.1 - 2e-14 53.3 2.3 0.017 15.6 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EEA19031.1 - 2e-14 53.4 1.6 3.5e-06 27.2 0.3 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19031.1 - 9.9e-14 50.1 5.6 0.19 12.4 0.0 6.9 8 0 0 8 8 8 4 Ankyrin repeat IRK PF01007.20 EEA19031.1 - 0.00066 19.5 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain AIM24 PF01987.17 EEA19032.1 - 7e-49 166.4 0.1 1e-48 165.9 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 eIF-5_eIF-2B PF01873.17 EEA19033.1 - 8.5e-41 138.5 0.1 1.4e-40 137.8 0.1 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 EEA19033.1 - 0.22 11.1 1.8 0.51 9.9 1.8 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding GET2 PF08690.10 EEA19033.1 - 0.23 11.1 4.6 0.3 10.7 4.6 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Peptidase_M13 PF01431.21 EEA19033.1 - 0.26 10.8 2.4 0.48 10.0 2.4 1.3 1 0 0 1 1 1 0 Peptidase family M13 Arc_trans_TRASH PF08394.10 EEA19033.1 - 1.6 9.1 7.6 1.2 9.5 0.4 2.6 1 1 1 2 2 2 0 Archaeal TRASH domain zf-HYPF PF07503.12 EEA19033.1 - 4.6 7.1 6.9 23 4.8 4.0 2.7 2 1 1 3 3 3 0 HypF finger LAT2 PF15703.5 EEA19034.1 - 0.021 14.7 0.2 0.027 14.4 0.2 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells family member 2 Zn_clus PF00172.18 EEA19035.1 - 0.07 13.3 6.8 0.11 12.6 6.8 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2149 PF09919.9 EEA19036.1 - 0.68 10.2 2.6 2.2 8.6 0.3 2.2 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) RRM_1 PF00076.22 EEA19038.1 - 1.7e-21 75.8 0.0 2.2e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA19038.1 - 0.0038 17.3 0.0 0.0055 16.8 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif GRP PF07172.11 EEA19038.1 - 0.082 13.6 25.0 0.12 13.1 25.0 1.4 1 0 0 1 1 1 0 Glycine rich protein family ChaC PF04752.12 EEA19039.1 - 1.1e-52 178.7 0.0 1.4e-52 178.4 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein adh_short PF00106.25 EEA19040.1 - 1.5e-21 76.7 0.2 9.8e-20 70.8 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19040.1 - 5.7e-14 52.2 0.1 4.8e-12 45.9 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19040.1 - 1e-08 35.3 0.2 1.7e-08 34.6 0.2 1.4 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA19040.1 - 0.033 13.3 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein EF-hand_6 PF13405.6 EEA19041.1 - 5.6e-20 69.5 3.7 1.6e-06 27.6 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EEA19041.1 - 8.1e-19 65.7 10.5 1.3e-06 27.5 0.2 4.4 4 1 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EEA19041.1 - 5.2e-18 64.6 5.5 2.4e-08 33.7 0.0 4.1 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_7 PF13499.6 EEA19041.1 - 8.3e-18 64.6 2.8 3.2e-07 30.7 0.0 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA19041.1 - 2.3e-13 48.9 8.8 8.9e-06 25.0 0.5 3.9 3 1 0 3 3 3 3 EF hand DDT PF02791.17 EEA19041.1 - 0.056 13.8 0.0 0.53 10.6 0.1 2.2 1 1 1 2 2 2 0 DDT domain Caleosin PF05042.13 EEA19041.1 - 0.14 12.1 1.4 21 5.0 0.1 3.0 2 1 1 3 3 3 0 Caleosin related protein MFS_1 PF07690.16 EEA19042.1 - 4.3e-49 167.3 67.4 8.7e-47 159.7 46.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA19042.1 - 1.9e-21 76.1 16.4 1.9e-21 76.1 16.4 2.0 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA19042.1 - 1.5e-13 50.4 13.3 1.5e-13 50.4 13.3 3.3 2 1 0 3 3 3 1 Sugar (and other) transporter p450 PF00067.22 EEA19044.1 - 3.6e-68 230.4 0.0 4.1e-68 230.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EEA19045.1 - 2.4e-18 66.1 0.9 2.4e-18 66.1 0.9 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19045.1 - 5.2e-09 36.1 9.2 8.8e-09 35.4 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MAGP PF05507.11 EEA19045.1 - 0.12 12.7 1.2 0.3 11.5 1.2 1.6 1 0 0 1 1 1 0 Microfibril-associated glycoprotein (MAGP) Acyl_transf_1 PF00698.21 EEA19046.1 - 0.0049 16.4 0.0 0.0061 16.1 0.0 1.0 1 0 0 1 1 1 1 Acyl transferase domain SRF-TF PF00319.18 EEA19047.1 - 3.5e-24 84.0 0.2 5.6e-24 83.4 0.2 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF1708 PF08101.11 EEA19048.1 - 1.1e-178 594.9 0.0 2.1e-178 593.9 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1708) DUF2406 PF10295.9 EEA19049.1 - 7.2e-27 93.9 0.1 7.2e-27 93.9 0.1 2.4 2 1 0 2 2 2 1 Uncharacterised protein (DUF2406) Caskin-Pro-rich PF16907.5 EEA19049.1 - 0.039 14.5 0.4 0.039 14.5 0.4 2.9 2 0 0 2 2 2 0 Proline rich region of Caskin proteins DUF3602 PF12223.8 EEA19050.1 - 3.3e-22 78.9 11.3 3.6e-21 75.5 5.3 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) Mito_carr PF00153.27 EEA19051.1 - 1.9e-46 156.0 6.7 9.4e-18 63.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 EEA19052.1 - 9.8e-45 150.4 5.8 2.4e-15 56.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CBS PF00571.28 EEA19053.1 - 7.9e-08 32.6 0.2 0.17 12.3 0.0 3.7 2 1 1 3 3 3 3 CBS domain VMA21 PF09446.10 EEA19054.1 - 4.5e-13 49.1 5.5 6.6e-13 48.6 5.5 1.3 1 0 0 1 1 1 1 VMA21-like domain TMEM100 PF16311.5 EEA19054.1 - 0.015 14.9 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 100 Ribosomal_L35Ae PF01247.18 EEA19055.1 - 3.3e-44 149.0 0.4 3.7e-44 148.8 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EEA19055.1 - 0.0002 21.5 0.0 0.17 12.1 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain DUF2080 PF09853.9 EEA19055.1 - 0.23 11.2 1.2 1.8 8.4 0.2 2.2 1 1 1 2 2 2 0 Putative transposon-encoded protein (DUF2080) Ribosomal_L35Ae PF01247.18 EEA19056.1 - 5.6e-30 103.4 0.3 6.4e-30 103.2 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EEA19056.1 - 0.012 15.8 0.1 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 RimM N-terminal domain G6PD_C PF02781.16 EEA19057.1 - 4.9e-114 380.4 0.0 9.3e-114 379.5 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EEA19057.1 - 2e-61 207.7 0.1 3.5e-61 206.9 0.1 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain G6PD_C PF02781.16 EEA19058.1 - 4.6e-114 380.5 0.0 8.9e-114 379.6 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EEA19058.1 - 1.9e-61 207.8 0.1 3.4e-61 206.9 0.1 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain MFS_2 PF13347.6 EEA19059.1 - 9.3e-12 44.2 11.5 9.3e-12 44.2 11.5 2.3 2 1 1 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 EEA19059.1 - 0.0014 17.5 1.8 0.0029 16.5 1.8 1.6 1 1 0 1 1 1 1 MFS_1 like family Tail_P2_I PF09684.10 EEA19059.1 - 0.05 13.5 0.1 0.19 11.7 0.1 1.9 1 1 0 1 1 1 0 Phage tail protein (Tail_P2_I) DJ-1_PfpI PF01965.24 EEA19061.1 - 2.5e-13 50.2 0.0 5.8e-13 49.0 0.0 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EEA19061.1 - 2.1e-09 37.4 0.0 1.8e-08 34.3 0.0 2.0 1 1 0 1 1 1 1 ThiJ/PfpI family-like SNF2_N PF00176.23 EEA19062.1 - 1.4e-52 178.6 0.2 2.4e-52 177.8 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA19062.1 - 1.1e-19 70.9 0.1 7.9e-19 68.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA19062.1 - 8.2e-10 38.9 0.1 3.9e-09 36.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA19062.1 - 3.9e-05 23.0 0.1 3.9e-05 23.0 0.1 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase HIGH_NTase1_ass PF16581.5 EEA19062.1 - 0.056 13.4 0.2 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Cytidyltransferase-related C-terminal region FGAR-AT_N PF18076.1 EEA19062.1 - 0.062 13.3 1.8 2.6 8.0 0.0 3.1 2 1 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase N-terminal HHH_3 PF12836.7 EEA19062.1 - 0.064 13.5 0.3 0.32 11.3 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif Dus PF01207.17 EEA19064.1 - 4.7e-44 150.7 0.0 9.9e-44 149.7 0.0 1.5 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) PAN_1 PF00024.26 EEA19065.1 - 2.2e-13 50.0 15.0 0.00023 21.0 1.6 3.3 3 0 0 3 3 3 3 PAN domain MANEC PF07502.14 EEA19065.1 - 0.0049 17.1 7.0 0.16 12.2 0.4 3.3 3 0 0 3 3 3 2 MANEC domain TrbC PF04956.13 EEA19065.1 - 0.012 15.8 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family G6B PF15096.6 EEA19065.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 G6B family Pyrophosphatase PF00719.19 EEA19066.1 - 1.5e-57 193.9 0.1 2e-57 193.5 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase MRP_L53 PF10780.9 EEA19067.1 - 5.5e-15 55.3 0.1 1.3e-14 54.1 0.1 1.7 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Sec20 PF03908.13 EEA19068.1 - 3.8e-17 62.0 6.4 8.6e-17 60.8 1.5 2.8 3 0 0 3 3 3 1 Sec20 DUF3510 PF12022.8 EEA19068.1 - 0.017 15.5 1.9 0.047 14.1 1.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) V-SNARE PF05008.15 EEA19068.1 - 0.14 12.6 3.3 1 9.8 0.2 3.2 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus CorA PF01544.18 EEA19068.1 - 0.85 8.9 5.0 3.5 6.9 0.3 2.5 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein CUT PF02376.15 EEA19068.1 - 0.87 9.8 4.4 10 6.3 4.4 2.4 1 1 0 1 1 1 0 CUT domain Rep_fac_C PF08542.11 EEA19069.1 - 1.1e-21 77.1 0.1 2.8e-21 75.7 0.1 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EEA19069.1 - 4.1e-15 56.4 0.0 1.6e-14 54.5 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EEA19069.1 - 8.7e-13 48.4 0.0 1.5e-11 44.3 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EEA19069.1 - 7.9e-09 35.7 0.0 2.4e-08 34.1 0.0 1.9 2 1 0 2 2 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EEA19069.1 - 1.4e-05 25.6 0.3 0.00084 19.8 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EEA19069.1 - 1.7e-05 24.7 0.1 0.0001 22.1 0.0 2.2 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 EEA19069.1 - 2.2e-05 24.7 0.1 8.1e-05 22.9 0.1 2.1 1 0 0 1 1 1 1 AAA C-terminal domain AAA_22 PF13401.6 EEA19069.1 - 9.1e-05 22.8 0.0 0.00034 20.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EEA19069.1 - 0.00022 20.7 0.0 0.015 14.7 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 EEA19069.1 - 0.00026 20.4 0.0 0.00046 19.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 EEA19069.1 - 0.00031 20.6 0.0 0.00031 20.6 0.0 1.9 2 1 0 3 3 2 1 AAA domain AAA_24 PF13479.6 EEA19069.1 - 0.00055 19.7 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EEA19069.1 - 0.0011 18.9 0.0 0.0061 16.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EEA19069.1 - 0.0014 18.6 0.0 0.0033 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA19069.1 - 0.0043 17.4 0.0 0.031 14.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EEA19069.1 - 0.0069 15.6 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DNA_pol3_delta PF06144.13 EEA19069.1 - 0.0084 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_7 PF12775.7 EEA19069.1 - 0.0085 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region DEAD PF00270.29 EEA19069.1 - 0.018 14.8 0.0 0.13 12.0 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_18 PF13238.6 EEA19069.1 - 0.024 15.2 0.0 0.094 13.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EEA19069.1 - 0.024 14.3 0.0 0.088 12.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EEA19069.1 - 0.028 14.3 0.2 0.4 10.6 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EEA19069.1 - 0.03 14.6 0.0 0.067 13.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 EEA19069.1 - 0.042 13.9 0.0 0.47 10.4 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.17 EEA19069.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_23 PF13476.6 EEA19069.1 - 0.15 12.6 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ank_3 PF13606.6 EEA19071.1 - 0.00027 21.1 0.2 18 6.3 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_2 PF12796.7 EEA19071.1 - 0.0005 20.6 0.0 0.01 16.4 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19071.1 - 0.00081 19.9 0.1 7.1 7.3 0.0 3.8 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA19071.1 - 0.0021 18.3 0.0 0.035 14.4 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EEA19071.1 - 0.0089 16.4 0.2 5.8 7.5 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat Myco_19_kDa PF05481.12 EEA19071.1 - 0.076 13.3 0.2 0.17 12.2 0.2 1.5 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen Gly-zipper_Omp PF13488.6 EEA19072.1 - 0.029 14.4 7.5 0.055 13.5 7.5 1.4 1 0 0 1 1 1 0 Glycine zipper Gly-zipper_YMGG PF13441.6 EEA19072.1 - 0.07 12.9 5.7 0.12 12.1 5.7 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Srg PF02118.21 EEA19072.1 - 0.34 10.5 1.8 0.51 10.0 1.8 1.1 1 0 0 1 1 1 0 Srg family chemoreceptor DUF2273 PF10031.9 EEA19072.1 - 0.64 10.1 7.6 1.2 9.2 7.6 1.3 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) Yip1 PF04893.17 EEA19072.1 - 0.65 9.7 4.4 1.1 9.0 4.4 1.3 1 1 0 1 1 1 0 Yip1 domain FAD_binding_2 PF00890.24 EEA19073.1 - 4.8e-126 421.2 3.5 6.2e-126 420.8 3.5 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EEA19073.1 - 1.6e-44 151.0 1.3 2.4e-44 150.4 1.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EEA19073.1 - 2.4e-06 27.0 0.2 0.00091 18.5 0.1 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA19073.1 - 2.8e-05 23.4 1.1 0.024 13.7 1.9 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EEA19073.1 - 0.00025 20.3 0.2 0.049 12.9 0.1 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EEA19073.1 - 0.0037 16.6 0.2 0.0075 15.6 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA19073.1 - 0.0065 16.1 0.9 0.02 14.5 0.9 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA19073.1 - 0.21 10.3 1.5 0.93 8.1 0.8 2.3 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.6 EEA19073.1 - 2.6 7.2 3.8 4.3 6.5 0.8 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase AAA PF00004.29 EEA19074.1 - 5.9e-41 140.0 0.0 1.1e-40 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA19074.1 - 7.8e-06 25.6 0.1 2e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EEA19074.1 - 7e-05 23.1 0.0 0.0059 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA19074.1 - 0.00011 22.2 0.0 0.00043 20.3 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA19074.1 - 0.00023 21.3 0.0 0.00069 19.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA19074.1 - 0.00032 21.1 0.1 0.008 16.6 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EEA19074.1 - 0.0019 17.4 0.0 0.0035 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EEA19074.1 - 0.0082 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EEA19074.1 - 0.02 15.1 0.1 0.063 13.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EEA19074.1 - 0.029 13.9 0.0 0.097 12.2 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EEA19074.1 - 0.049 13.8 0.0 0.094 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA19074.1 - 0.058 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EEA19074.1 - 0.082 12.6 0.1 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EEA19074.1 - 0.084 12.7 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF4164 PF13747.6 EEA19074.1 - 0.096 13.0 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) AAA_24 PF13479.6 EEA19074.1 - 0.097 12.4 0.0 0.24 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA19074.1 - 0.14 12.7 0.0 0.48 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EEA19074.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EEA19074.1 - 0.16 11.3 0.0 0.36 10.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 EEA19075.1 - 4.1e-41 140.5 0.0 6.6e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA19075.1 - 6.7e-06 25.8 0.1 1.5e-05 24.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EEA19075.1 - 4e-05 23.9 0.0 0.0044 17.3 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA19075.1 - 6.6e-05 22.9 0.1 0.00029 20.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA19075.1 - 0.00021 21.4 0.0 0.00046 20.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA19075.1 - 0.00023 21.6 0.1 0.005 17.2 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EEA19075.1 - 0.0013 17.9 0.0 0.0023 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EEA19075.1 - 0.0057 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EEA19075.1 - 0.019 14.5 0.0 0.063 12.8 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EEA19075.1 - 0.026 14.8 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EEA19075.1 - 0.039 14.1 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA19075.1 - 0.051 14.0 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EEA19075.1 - 0.062 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EEA19075.1 - 0.072 12.8 0.1 0.21 11.3 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA19075.1 - 0.099 13.2 0.0 0.34 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EEA19075.1 - 0.12 12.3 0.0 7.6 6.4 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EEA19075.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EEA19075.1 - 0.14 11.6 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cpn60_TCP1 PF00118.24 EEA19076.1 - 7.9e-150 499.7 13.7 8.9e-150 499.5 13.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RNA_Me_trans PF04252.13 EEA19076.1 - 0.11 12.1 0.1 0.75 9.3 0.0 2.3 2 0 0 2 2 2 0 Predicted SAM-dependent RNA methyltransferase DPPIV_N PF00930.21 EEA19077.1 - 5.8e-113 377.2 0.5 9.2e-113 376.6 0.5 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EEA19077.1 - 1.4e-57 194.6 7.4 1.9e-57 194.1 4.4 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EEA19077.1 - 4.6e-06 26.4 6.4 0.00015 21.4 3.6 2.8 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EEA19077.1 - 4.1e-05 23.4 0.6 0.00013 21.7 0.6 1.8 1 1 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 EEA19077.1 - 0.00022 21.0 0.5 0.00058 19.6 0.2 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 EEA19077.1 - 0.00026 20.6 0.0 0.0017 17.9 0.0 2.2 2 1 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S10 PF00450.22 EEA19077.1 - 0.00065 19.2 0.1 0.22 10.9 0.0 2.7 3 0 0 3 3 3 2 Serine carboxypeptidase COesterase PF00135.28 EEA19077.1 - 0.0025 16.8 0.0 0.0039 16.1 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 EEA19077.1 - 0.0048 16.7 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase PAF-AH_p_II PF03403.13 EEA19077.1 - 0.012 14.2 0.0 1.8 7.0 0.0 2.2 1 1 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II BAAT_C PF08840.11 EEA19077.1 - 0.025 14.5 0.1 4.7 7.1 0.2 2.4 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Questin_oxidase PF14027.6 EEA19078.1 - 8.2e-66 222.9 0.8 9.8e-66 222.6 0.8 1.1 1 0 0 1 1 1 1 Questin oxidase-like HECT_2 PF09814.9 EEA19079.1 - 1.7e-110 369.4 0.0 2e-110 369.2 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Rtt102p PF09510.10 EEA19080.1 - 0.012 15.8 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein TauD PF02668.16 EEA19081.1 - 5.2e-60 203.5 2.2 6.5e-60 203.2 2.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EEA19082.1 - 4e-22 78.6 19.6 4e-22 78.6 19.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2070 PF09843.9 EEA19082.1 - 9 4.4 13.7 0.025 12.9 4.0 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) F-box-like PF12937.7 EEA19083.1 - 1.5e-05 24.7 0.4 3.4e-05 23.7 0.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA19083.1 - 0.0043 16.9 0.3 0.01 15.7 0.3 1.7 1 0 0 1 1 1 1 F-box domain Cwf_Cwc_15 PF04889.12 EEA19084.1 - 0.15 11.8 13.0 0.2 11.3 13.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein GST_N_3 PF13417.6 EEA19085.1 - 4.2e-08 33.5 0.0 1.3e-07 31.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA19085.1 - 1.2e-06 28.4 0.0 3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA19085.1 - 6.8e-05 23.0 0.0 0.00012 22.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA19085.1 - 0.00024 21.3 0.0 0.00053 20.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA19085.1 - 0.039 14.2 0.0 0.081 13.1 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ribosomal_L37 PF08561.10 EEA19086.1 - 5.1e-43 146.4 0.2 7.6e-43 145.9 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 adh_short PF00106.25 EEA19087.1 - 1.2e-23 83.6 0.2 4.1e-20 72.1 0.2 2.7 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19087.1 - 5.6e-11 42.4 0.2 9.3e-09 35.2 0.1 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19087.1 - 0.00029 20.8 0.0 0.00067 19.6 0.0 1.5 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 EEA19087.1 - 0.0095 15.3 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) AA_permease_2 PF13520.6 EEA19088.1 - 3e-50 171.3 44.2 4e-50 170.9 44.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA19088.1 - 1.7e-20 73.1 37.1 2.3e-20 72.6 37.1 1.1 1 0 0 1 1 1 1 Amino acid permease AAA PF00004.29 EEA19089.1 - 1.7e-51 174.1 0.0 2.6e-43 147.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA19089.1 - 1.5e-08 34.3 8.0 9.5e-05 22.1 0.2 3.0 3 0 0 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 EEA19089.1 - 5.8e-05 23.5 0.0 0.023 15.1 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EEA19089.1 - 7.9e-05 22.5 0.0 0.00042 20.1 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 EEA19089.1 - 0.00058 19.0 0.0 0.00096 18.3 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 EEA19089.1 - 0.0012 19.2 0.1 0.016 15.6 0.0 2.7 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.14 EEA19089.1 - 0.0031 17.7 0.0 0.0085 16.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EEA19089.1 - 0.0032 17.6 0.0 0.45 10.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EEA19089.1 - 0.0035 16.9 0.1 0.043 13.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA19089.1 - 0.0044 17.3 0.0 0.046 14.0 0.0 2.8 2 1 1 3 3 2 1 AAA domain TIP49 PF06068.13 EEA19089.1 - 0.0067 15.7 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EEA19089.1 - 0.0087 15.8 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EEA19089.1 - 0.017 15.7 0.0 0.12 12.9 0.0 2.4 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.21 EEA19089.1 - 0.023 14.1 0.1 0.051 12.9 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EEA19089.1 - 0.026 14.5 0.1 0.16 12.0 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EEA19089.1 - 0.032 14.2 0.0 0.13 12.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EEA19089.1 - 0.037 13.4 0.0 0.082 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 EEA19089.1 - 0.043 13.3 0.0 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EEA19089.1 - 0.08 13.0 0.0 1.9 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EEA19089.1 - 0.09 12.2 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EEA19089.1 - 0.094 13.0 0.0 0.31 11.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 EEA19089.1 - 0.1 12.3 0.1 0.96 9.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EEA19089.1 - 0.12 11.5 0.0 3.1 6.9 0.0 2.5 3 0 0 3 3 3 0 NB-ARC domain MAGE_N PF12440.8 EEA19089.1 - 0.36 11.5 2.1 1.5 9.5 2.1 2.1 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal MFS_1 PF07690.16 EEA19090.1 - 6.7e-33 114.1 57.6 3.7e-31 108.3 57.3 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA19090.1 - 8.1e-23 80.7 20.4 1e-22 80.3 20.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA19090.1 - 2.2e-14 53.2 2.6 2.2e-14 53.2 2.6 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EEA19090.1 - 2.2 6.4 15.1 0.18 10.1 5.6 3.0 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family zf-C2H2 PF00096.26 EEA19091.1 - 0.00015 22.1 19.7 0.00055 20.3 5.1 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 EEA19091.1 - 0.0012 18.5 0.2 0.0012 18.5 0.2 2.8 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 EEA19091.1 - 0.0055 17.4 4.4 0.0055 17.4 4.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA19091.1 - 0.35 11.2 8.1 0.82 10.0 5.4 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EEA19091.1 - 0.63 10.1 6.0 3.1 7.9 0.5 2.7 2 0 0 2 2 2 0 BED zinc finger AA_permease_2 PF13520.6 EEA19092.1 - 5.9e-55 186.8 43.7 7.2e-55 186.5 43.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA19092.1 - 6.3e-23 81.1 35.2 8.6e-23 80.7 35.2 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3493 PF11998.8 EEA19092.1 - 0.3 11.3 2.9 0.29 11.3 0.4 2.4 2 1 0 2 2 2 0 Low psii accumulation1 / Rep27 Cu_amine_oxid PF01179.20 EEA19093.1 - 9.6e-154 512.2 0.0 1.1e-153 512.0 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EEA19093.1 - 6.5e-18 65.0 0.0 1.6e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EEA19093.1 - 4e-08 33.4 0.0 7.5e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Aldedh PF00171.22 EEA19094.1 - 7.2e-185 614.9 0.0 8.1e-185 614.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA19094.1 - 0.2 11.1 0.0 4.5 6.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) SVS_QK PF10578.9 EEA19094.1 - 0.81 10.4 2.6 45 5.0 0.1 2.9 3 0 0 3 3 3 0 Seminal vesicle protein repeat DUF3818 PF12825.7 EEA19095.1 - 1.8e-133 444.8 3.0 1.8e-133 444.8 3.0 2.0 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EEA19095.1 - 4.9e-39 133.3 0.6 9e-39 132.4 0.6 1.5 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EEA19095.1 - 9.4e-11 41.7 1.1 2.8e-10 40.2 0.0 2.4 3 0 0 3 3 3 1 PX domain MFS_1 PF07690.16 EEA19096.1 - 3.8e-23 82.0 41.7 7.2e-23 81.1 37.9 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19096.1 - 2.9e-08 33.0 19.0 7.5e-05 21.8 11.1 2.4 1 1 0 2 2 2 2 Sugar (and other) transporter zf-GRF PF06839.12 EEA19097.1 - 4.1e-07 30.0 5.1 6.7e-07 29.3 5.1 1.4 1 0 0 1 1 1 1 GRF zinc finger SLD3 PF08639.10 EEA19097.1 - 0.015 14.1 4.1 0.024 13.4 4.1 1.4 1 1 0 1 1 1 0 DNA replication regulator SLD3 Met_10 PF02475.16 EEA19098.1 - 2.7e-67 226.4 0.0 4.7e-67 225.6 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EEA19098.1 - 0.065 12.4 0.0 0.13 11.4 0.0 1.4 2 0 0 2 2 2 0 N2,N2-dimethylguanosine tRNA methyltransferase RNA_pol_Rpb4 PF03874.16 EEA19099.1 - 1.7e-25 89.7 4.9 2.7e-25 89.1 4.9 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb4 Cut8 PF08559.10 EEA19099.1 - 0.0006 19.5 1.6 0.00074 19.2 1.6 1.2 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein TROVE PF05731.11 EEA19099.1 - 0.038 13.0 0.2 0.042 12.9 0.2 1.1 1 0 0 1 1 1 0 TROVE domain Fungal_trans PF04082.18 EEA19100.1 - 1e-18 67.3 0.0 2.1e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19100.1 - 0.0019 18.3 5.0 0.0033 17.5 5.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ashwin PF15323.6 EEA19100.1 - 7.6 6.5 14.7 6.5 6.7 1.0 2.3 2 0 0 2 2 2 0 Developmental protein Ribosomal_S8e PF01201.22 EEA19101.1 - 1.6e-43 148.2 1.7 2.7e-43 147.4 1.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e PfkB PF00294.24 EEA19101.1 - 1.7e-12 47.2 0.0 2.8e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Ribosomal_L21p PF00829.21 EEA19102.1 - 2.6e-08 34.0 0.0 4.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Peptidase_M18 PF02127.15 EEA19103.1 - 6.3e-169 562.3 0.0 7.3e-169 562.1 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) WD40 PF00400.32 EEA19104.1 - 9.7e-25 86.4 11.5 2.5e-05 24.9 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19104.1 - 1.3e-14 54.2 5.8 0.00022 21.5 0.3 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA19104.1 - 7.3e-08 32.5 0.1 0.055 13.3 0.0 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA19104.1 - 0.02 13.9 0.0 0.062 12.2 0.0 1.8 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 EEA19104.1 - 0.18 10.7 1.1 1 8.2 0.1 2.2 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain WD40 PF00400.32 EEA19105.1 - 9.4e-25 86.4 11.5 2.5e-05 24.9 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19105.1 - 1.3e-14 54.2 5.8 0.00022 21.5 0.3 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA19105.1 - 7.2e-08 32.5 0.1 0.055 13.3 0.0 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA19105.1 - 0.02 13.9 0.0 0.062 12.3 0.0 1.8 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 EEA19105.1 - 0.17 10.7 1.1 1 8.2 0.1 2.2 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain E3_binding PF02817.17 EEA19106.1 - 5e-07 29.9 0.0 1.4e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 e3 binding domain CcmD PF04995.14 EEA19107.1 - 0.00067 19.7 0.1 0.0018 18.3 0.1 1.8 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) CcmD PF04995.14 EEA19108.1 - 0.00067 19.7 0.1 0.0018 18.3 0.1 1.8 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) SMC_N PF02463.19 EEA19109.1 - 3.8e-59 199.8 0.1 1e-57 195.2 0.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA19109.1 - 5.1e-31 107.4 0.0 2e-30 105.5 0.0 2.1 2 0 0 2 2 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EEA19109.1 - 9.8e-11 42.0 15.3 2.7e-05 24.1 0.0 4.3 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA19109.1 - 5.6e-09 36.8 23.5 5.6e-09 36.8 23.5 6.4 4 1 1 5 5 4 2 AAA domain AAA_29 PF13555.6 EEA19109.1 - 3.9e-08 32.9 0.0 9.6e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain GFD1 PF17331.2 EEA19109.1 - 0.0023 18.1 7.1 0.01 16.0 7.1 2.3 1 0 0 1 1 1 1 GFD1 mRNA transport factor SbcCD_C PF13558.6 EEA19109.1 - 0.0029 17.8 0.0 0.018 15.2 0.0 2.5 2 0 0 2 2 1 1 Putative exonuclease SbcCD, C subunit TMP_2 PF06791.13 EEA19109.1 - 0.011 15.5 2.5 0.013 15.2 0.7 2.1 2 0 0 2 2 2 0 Prophage tail length tape measure protein ABC_tran PF00005.27 EEA19109.1 - 0.96 10.0 0.0 0.96 10.0 0.0 6.4 4 3 1 5 5 4 0 ABC transporter DUF1664 PF07889.12 EEA19109.1 - 1.8 8.6 60.4 0.047 13.7 5.3 8.4 4 3 4 9 9 9 0 Protein of unknown function (DUF1664) DUF2939 PF11159.8 EEA19109.1 - 2.4 8.6 4.7 13 6.3 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2939) FPP PF05911.11 EEA19109.1 - 4.1 5.5 89.9 0.01 14.1 6.8 4.1 3 1 0 4 4 4 0 Filament-like plant protein, long coiled-coil AAA_15 PF13175.6 EEA19109.1 - 8.8 5.9 68.8 34 4.0 0.6 4.8 3 1 0 3 3 3 0 AAA ATPase domain Filament PF00038.21 EEA19109.1 - 9.1 5.8 99.0 0.18 11.4 3.1 7.0 4 1 2 6 6 6 0 Intermediate filament protein DUF2841 PF11001.8 EEA19110.1 - 6.4e-51 171.6 0.1 8.7e-51 171.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) DUF2838 PF10998.8 EEA19111.1 - 1.7e-42 144.1 8.4 1.7e-42 144.1 8.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2838) LETM1 PF07766.13 EEA19112.1 - 3.6e-104 347.8 0.1 3.6e-104 347.8 0.1 1.4 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 EEA19112.1 - 0.00017 21.2 0.1 0.01 15.5 0.0 3.0 3 0 0 3 3 3 1 SAP domain BPL_N PF09825.9 EEA19112.1 - 2.4 7.2 12.1 1.6 7.7 0.1 2.3 2 1 0 2 2 2 0 Biotin-protein ligase, N terminal NUDIX PF00293.28 EEA19113.1 - 6.4e-09 35.9 0.1 2.9e-08 33.8 0.0 2.0 1 1 1 2 2 2 1 NUDIX domain DUF5524 PF17662.1 EEA19114.1 - 0.0012 18.3 0.7 0.002 17.5 0.0 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5524) LPD7 PF18821.1 EEA19116.1 - 0.044 13.9 0.1 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 7 Glyco_hydro_38N PF01074.22 EEA19117.1 - 2.5e-88 296.2 0.6 5.3e-88 295.1 0.6 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EEA19117.1 - 2e-57 194.7 0.1 2.7e-56 191.0 0.1 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EEA19117.1 - 1.3e-27 95.8 0.0 3e-27 94.6 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EEA19117.1 - 1.1e-12 47.9 0.0 4.2e-12 46.0 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 EEA19117.1 - 0.045 12.9 0.0 0.17 11.0 0.0 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 57 NuA4 PF09340.10 EEA19118.1 - 3e-27 94.3 0.5 9.9e-27 92.6 0.5 1.9 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Ctr PF04145.15 EEA19119.1 - 6.4e-30 104.7 2.2 8e-30 104.4 2.2 1.1 1 0 0 1 1 1 1 Ctr copper transporter family T2SSF PF00482.23 EEA19119.1 - 0.061 13.3 0.2 0.085 12.8 0.2 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Ctr PF04145.15 EEA19120.1 - 3.8e-25 89.2 14.1 1.5e-24 87.3 14.1 1.7 1 1 0 1 1 1 1 Ctr copper transporter family Ctr PF04145.15 EEA19121.1 - 7.8e-14 52.5 0.1 9.8e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Cupin_8 PF13621.6 EEA19122.1 - 5.1e-16 59.1 0.1 2.1e-11 44.0 0.0 2.2 1 1 1 2 2 2 2 Cupin-like domain JmjC PF02373.22 EEA19122.1 - 1.2e-09 38.6 0.2 0.0019 18.6 0.1 2.5 2 0 0 2 2 2 2 JmjC domain, hydroxylase F-box-like PF12937.7 EEA19122.1 - 8.8e-07 28.7 0.5 2e-06 27.6 0.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA19122.1 - 1.1e-06 28.4 0.1 2.4e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 F-box domain Cupin_4 PF08007.12 EEA19122.1 - 0.055 12.9 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein DEAD PF00270.29 EEA19123.1 - 1.2e-44 152.2 1.1 2.1e-44 151.4 1.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA19123.1 - 3.6e-32 111.0 0.2 5e-31 107.3 0.1 2.5 2 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA19123.1 - 8.3e-07 29.2 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EEA19123.1 - 0.00012 21.9 0.2 0.00022 21.0 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA19123.1 - 0.00047 20.5 0.2 0.0032 17.8 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA19123.1 - 0.0081 16.4 1.2 0.054 13.8 1.2 2.3 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 EEA19123.1 - 0.0098 15.3 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit fragilysinNterm PF16376.5 EEA19123.1 - 0.075 12.8 0.1 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 N-terminal domain of fragilysin Flavi_DEAD PF07652.14 EEA19123.1 - 0.081 12.9 0.0 0.81 9.7 0.0 2.3 1 1 0 1 1 1 0 Flavivirus DEAD domain DUF1664 PF07889.12 EEA19124.1 - 0.00031 20.8 1.5 0.098 12.7 0.1 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) CLZ PF16526.5 EEA19124.1 - 0.022 15.1 1.6 0.083 13.3 0.4 2.4 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADIP PF11559.8 EEA19124.1 - 0.025 14.7 0.8 0.054 13.6 0.8 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Cnn_1N PF07989.11 EEA19124.1 - 0.026 14.7 0.3 0.19 11.9 0.1 2.3 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 FlaC_arch PF05377.11 EEA19124.1 - 0.031 14.7 1.9 2.2 8.7 0.1 3.2 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) YabA PF06156.13 EEA19124.1 - 0.066 13.9 1.3 1.3 9.7 0.4 2.5 1 1 0 2 2 2 0 Initiation control protein YabA Taxilin PF09728.9 EEA19124.1 - 0.071 12.3 0.1 0.14 11.3 0.1 1.5 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Retrotrans_gag PF03732.17 EEA19124.1 - 0.077 13.3 0.2 1.9 8.8 0.0 2.4 2 0 0 2 2 2 0 Retrotransposon gag protein SOGA PF11365.8 EEA19124.1 - 0.14 13.3 1.5 2.1 9.5 0.2 2.5 1 1 1 2 2 2 0 Protein SOGA JIP_LZII PF16471.5 EEA19124.1 - 0.19 11.9 1.2 6.2 7.1 0.2 2.8 1 1 2 3 3 3 0 JNK-interacting protein leucine zipper II ATG16 PF08614.11 EEA19124.1 - 0.19 11.9 2.4 0.39 10.9 2.4 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 EEA19124.1 - 0.27 11.4 1.3 0.53 10.5 0.8 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FAA_hydrolase PF01557.18 EEA19125.1 - 7.2e-53 179.5 0.0 9e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Pkinase PF00069.25 EEA19126.1 - 8.3e-48 163.0 0.0 1.4e-47 162.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19126.1 - 2.5e-18 66.3 0.0 3.8e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EEA19126.1 - 0.00063 19.4 0.2 0.0012 18.5 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EEA19126.1 - 0.012 14.9 0.1 0.022 14.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA19126.1 - 0.013 15.4 0.1 0.087 12.7 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EEA19126.1 - 0.077 11.8 0.1 0.077 11.8 0.1 2.2 3 0 0 3 3 3 0 Fungal protein kinase Kinase-like PF14531.6 EEA19126.1 - 0.15 11.4 0.0 0.41 9.9 0.0 1.7 2 0 0 2 2 2 0 Kinase-like DUF4728 PF15860.5 EEA19127.1 - 0.099 13.3 5.0 0.8 10.4 1.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) PWI PF01480.17 EEA19128.1 - 1.7e-29 101.9 0.0 3.1e-29 101.1 0.0 1.4 1 0 0 1 1 1 1 PWI domain Zn_clus PF00172.18 EEA19130.1 - 2e-08 34.2 9.2 3.5e-08 33.4 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EEA19131.1 - 6.1e-35 120.4 0.0 8.2e-35 120.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19131.1 - 6.8e-19 68.4 0.0 8.4e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19131.1 - 8.5e-08 32.3 0.1 1.1e-07 31.9 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA19131.1 - 0.00025 21.0 0.0 0.00037 20.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 EEA19131.1 - 0.00032 20.8 0.0 0.00051 20.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EEA19131.1 - 0.00041 20.0 0.1 0.00074 19.2 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 EEA19131.1 - 0.0008 19.7 0.1 0.0014 18.9 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EEA19131.1 - 0.0014 18.1 0.0 0.006 16.1 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 EEA19131.1 - 0.079 13.1 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Hydrolase_6 PF13344.6 EEA19132.1 - 4.7e-29 100.5 0.0 8.7e-29 99.6 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA19132.1 - 8.9e-15 54.5 0.0 6.8e-14 51.7 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EEA19132.1 - 7.4e-11 42.7 0.0 0.00017 21.9 0.0 3.1 1 1 2 3 3 3 3 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA19132.1 - 0.00011 22.3 0.1 0.062 13.4 0.0 2.5 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase RRG8 PF17068.5 EEA19133.1 - 0.00094 18.7 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial FeoC PF09012.10 EEA19133.1 - 0.15 12.2 0.0 0.43 10.7 0.0 1.7 1 0 0 1 1 1 0 FeoC like transcriptional regulator CLP_protease PF00574.23 EEA19134.1 - 8e-76 254.0 0.0 9.8e-76 253.7 0.0 1.0 1 0 0 1 1 1 1 Clp protease Tugs PF17840.1 EEA19134.1 - 0.095 12.9 1.1 0.18 12.0 1.1 1.4 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain RRM_1 PF00076.22 EEA19135.1 - 5.1e-41 138.3 0.0 4.5e-19 68.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA19135.1 - 0.00038 20.5 0.0 0.11 12.6 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EEA19135.1 - 0.0066 16.4 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Sperm_Ag_HE2 PF05324.13 EEA19136.1 - 5 7.7 6.3 3.3 8.2 0.4 2.9 3 0 0 3 3 3 0 Sperm antigen HE2 MFS_1 PF07690.16 EEA19137.1 - 2.5e-33 115.5 60.6 2.9e-25 88.9 29.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3285 PF11688.8 EEA19137.1 - 0.034 14.1 0.8 0.12 12.2 0.8 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) Sugar_tr PF00083.24 EEA19138.1 - 4.4e-109 365.3 27.1 5.5e-109 365.0 27.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19138.1 - 1.4e-26 93.3 24.2 1.4e-26 93.3 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 EEA19138.1 - 0.022 14.5 1.3 0.022 14.5 1.3 3.4 4 0 0 4 4 4 0 Ion channel regulatory protein UNC-93 Aa_trans PF01490.18 EEA19140.1 - 4.8e-18 65.1 27.0 1.3e-17 63.6 27.0 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Acetyltransf_3 PF13302.7 EEA19141.1 - 5e-05 24.0 0.0 0.0002 22.0 0.0 2.0 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA19141.1 - 0.00023 21.4 0.1 0.001 19.3 0.1 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EEA19141.1 - 0.00087 19.2 0.1 0.0089 16.0 0.1 2.3 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EEA19141.1 - 0.03 14.7 0.0 0.062 13.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA19141.1 - 0.067 13.3 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Cys_Met_Meta_PP PF01053.20 EEA19142.1 - 1.1e-127 425.8 0.0 1.2e-127 425.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EEA19142.1 - 9.1e-09 34.7 0.1 1.3e-08 34.3 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA19142.1 - 7.6e-08 32.0 0.0 1.6e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EEA19142.1 - 6.1e-06 25.8 1.0 1.3e-05 24.7 1.0 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GDC-P PF02347.16 EEA19142.1 - 0.0022 16.9 0.0 0.0031 16.4 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.11 EEA19142.1 - 0.075 11.5 0.1 0.17 10.4 0.1 1.6 1 1 0 1 1 1 0 Methionine gamma-lyase BRK PF07533.16 EEA19142.1 - 0.26 10.9 1.3 0.48 10.1 0.2 2.1 2 0 0 2 2 2 0 BRK domain rve PF00665.26 EEA19143.1 - 1.5e-07 31.6 0.3 5.6e-06 26.5 0.0 2.9 3 0 0 3 3 3 1 Integrase core domain RVT_2 PF07727.14 EEA19143.1 - 4.8e-07 29.7 0.0 9.2e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA19143.1 - 0.00022 21.0 0.2 0.00073 19.3 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Integrase_H2C2 PF17921.1 EEA19143.1 - 0.032 14.3 1.4 0.46 10.6 0.1 2.8 2 0 0 2 2 2 0 Integrase zinc binding domain PAC4 PF16093.5 EEA19143.1 - 0.14 12.4 0.0 0.74 10.0 0.0 2.3 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Fungal_trans PF04082.18 EEA19144.1 - 0.033 13.2 0.2 0.049 12.7 0.2 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF4185 PF13810.6 EEA19144.1 - 0.19 10.9 0.0 0.37 10.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4185) Fungal_trans PF04082.18 EEA19145.1 - 0.031 13.3 0.2 0.046 12.8 0.2 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF4185 PF13810.6 EEA19145.1 - 0.18 11.0 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4185) ABC_tran PF00005.27 EEA19146.1 - 6.3e-50 169.2 0.3 3.4e-27 95.6 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EEA19146.1 - 7.5e-44 150.4 40.9 1.5e-25 90.4 15.8 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_16 PF13191.6 EEA19146.1 - 3.4e-06 27.5 1.0 0.014 15.7 0.1 3.1 2 2 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EEA19146.1 - 6.7e-06 26.2 4.7 0.03 14.4 0.1 3.3 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EEA19146.1 - 2.6e-05 24.2 7.0 0.21 11.4 0.5 4.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 EEA19146.1 - 2.8e-05 23.5 0.1 0.011 15.0 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin AAA_23 PF13476.6 EEA19146.1 - 0.00025 21.6 1.0 0.59 10.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EEA19146.1 - 0.00058 19.8 2.7 0.57 10.1 0.3 2.5 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 EEA19146.1 - 0.00065 19.2 8.3 0.51 9.7 0.4 4.3 3 2 1 4 4 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA19146.1 - 0.001 18.8 2.1 0.56 10.0 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EEA19146.1 - 0.0014 18.4 3.4 0.13 12.0 0.5 3.1 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 EEA19146.1 - 0.0025 16.8 2.0 0.46 9.4 0.1 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP-synt_ab PF00006.25 EEA19146.1 - 0.0028 17.3 0.3 0.96 9.1 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.19 EEA19146.1 - 0.0058 16.2 0.9 0.12 11.9 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 EEA19146.1 - 0.0068 16.6 0.3 4.8 7.4 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 EEA19146.1 - 0.04 13.3 0.7 7.5 5.8 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 EEA19146.1 - 0.047 12.6 3.8 0.3 10.0 0.3 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.6 EEA19146.1 - 0.067 13.5 3.5 12 6.2 0.4 3.2 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EEA19146.1 - 0.071 12.2 1.8 0.49 9.4 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 EEA19146.1 - 0.083 12.4 1.4 8.4 5.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region DEAD PF00270.29 EEA19146.1 - 0.09 12.5 0.4 8.5 6.1 0.0 3.2 3 0 0 3 3 3 0 DEAD/DEAH box helicase NACHT PF05729.12 EEA19146.1 - 0.11 12.4 1.5 0.58 10.0 0.2 2.3 2 0 0 2 2 2 0 NACHT domain MobB PF03205.14 EEA19146.1 - 0.11 12.3 1.8 0.96 9.4 0.2 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF87 PF01935.17 EEA19146.1 - 0.13 12.4 6.4 0.69 10.0 0.3 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_15 PF13175.6 EEA19146.1 - 0.15 11.7 0.5 16 5.0 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 EEA19146.1 - 0.2 11.2 0.3 3 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EEA19146.1 - 0.3 10.2 4.5 2.9 7.0 0.5 2.6 2 0 0 2 2 2 0 NB-ARC domain Dynamin_N PF00350.23 EEA19146.1 - 0.52 10.4 10.6 0.29 11.2 0.8 2.8 3 0 0 3 3 2 0 Dynamin family PgaD PF13994.6 EEA19146.1 - 0.64 10.1 5.6 2.9 7.9 0.6 2.8 2 0 0 2 2 2 0 PgaD-like protein ATPgrasp_N PF18130.1 EEA19147.1 - 8.4e-10 39.1 0.0 2.9e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp N-terminal domain ATP-grasp_4 PF13535.6 EEA19147.1 - 1.6e-09 37.5 0.1 7.9e-09 35.3 0.1 2.1 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EEA19147.1 - 3.7e-08 33.1 0.0 1.9e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EEA19147.1 - 0.00093 19.3 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain GSH-S_ATP PF02955.16 EEA19147.1 - 0.0041 16.5 0.0 0.0073 15.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain RimK PF08443.11 EEA19147.1 - 0.17 11.4 0.0 0.84 9.2 0.0 2.0 3 0 0 3 3 3 0 RimK-like ATP-grasp domain NAS PF03059.16 EEA19148.1 - 5.1e-28 98.2 0.0 6.4e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Nicotianamine synthase protein AMP-binding PF00501.28 EEA19149.1 - 4.1e-76 256.3 0.0 5.7e-76 255.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EEA19149.1 - 4.3e-50 170.7 5.4 2.8e-24 85.6 0.8 3.8 2 2 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EEA19149.1 - 7.5e-08 32.6 0.1 2.4e-07 31.0 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site MFS_1 PF07690.16 EEA19150.1 - 5.4e-15 55.2 17.6 5.4e-15 55.2 17.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EEA19150.1 - 0.017 13.4 1.3 0.038 12.3 1.3 1.7 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family AA_permease_2 PF13520.6 EEA19151.1 - 5.1e-58 196.9 47.5 6.3e-58 196.6 47.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA19151.1 - 3.7e-27 95.0 41.8 4.7e-27 94.7 41.8 1.0 1 0 0 1 1 1 1 Amino acid permease LysM PF01476.20 EEA19153.1 - 4.4e-13 49.1 0.5 0.00028 20.9 0.0 4.0 4 0 0 4 4 4 3 LysM domain Glyco_hydro_18 PF00704.28 EEA19154.1 - 5.2e-47 161.1 2.0 1.5e-46 159.6 1.9 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EEA19154.1 - 6.7e-11 42.5 17.0 6.7e-11 42.5 17.0 5.0 4 0 0 4 4 4 1 Chitin recognition protein DNase_NucA_NucB PF14040.6 EEA19154.1 - 2e-06 28.2 0.5 1.1e-05 25.8 0.2 2.4 2 1 0 2 2 2 1 Deoxyribonuclease NucA/NucB Glyco_hydro_114 PF03537.13 EEA19154.1 - 0.028 13.7 0.2 0.12 11.7 0.1 2.0 2 0 0 2 2 2 0 Glycoside-hydrolase family GH114 AJAP1_PANP_C PF15298.6 EEA19155.1 - 0.015 15.6 7.8 0.022 15.0 7.8 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus FSA_C PF10479.9 EEA19155.1 - 0.022 12.9 6.4 0.03 12.5 6.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PRR18 PF15671.5 EEA19155.1 - 0.033 14.1 4.4 0.044 13.7 4.4 1.1 1 0 0 1 1 1 0 Proline-rich protein family 18 Med12-LCEWAV PF12145.8 EEA19155.1 - 0.095 11.5 0.2 0.13 11.1 0.2 1.1 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain Mucin PF01456.17 EEA19155.1 - 0.87 9.6 30.1 0.49 10.4 27.6 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein SSP160 PF06933.11 EEA19155.1 - 6.8 4.7 24.6 9.8 4.2 24.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 EEA19155.1 - 8.3 4.2 11.9 11 3.8 11.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Lyase_1 PF00206.20 EEA19157.1 - 2.2e-86 290.1 0.0 3.2e-86 289.6 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EEA19157.1 - 1.1e-23 83.7 0.0 7.5e-23 81.1 0.0 2.3 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal MFS_1 PF07690.16 EEA19159.1 - 3.2e-20 72.4 46.8 2.1e-17 63.1 34.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19159.1 - 1.4e-09 37.4 19.5 9.8e-08 31.3 7.2 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter COX7C PF02935.16 EEA19159.1 - 0.26 11.6 0.1 0.26 11.6 0.1 4.1 4 0 0 4 4 4 0 Cytochrome c oxidase subunit VIIc DUF2393 PF09624.10 EEA19159.1 - 3.4 7.7 6.8 4.3 7.3 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2393) Methyltransf_25 PF13649.6 EEA19160.1 - 1.1e-05 26.1 0.0 1.8e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19160.1 - 0.00067 20.2 0.0 0.0012 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19160.1 - 0.0065 16.3 0.0 0.0087 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain SBF PF01758.16 EEA19161.1 - 8.4e-54 182.2 6.1 8.4e-54 182.2 6.1 1.9 2 1 0 2 2 2 1 Sodium Bile acid symporter family FA_hydroxylase PF04116.13 EEA19161.1 - 3.5 8.0 5.3 2.4 8.5 0.1 2.7 2 1 0 2 2 2 0 Fatty acid hydroxylase superfamily LMWPc PF01451.21 EEA19162.1 - 4e-21 75.9 0.0 5.4e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase FMN_red PF03358.15 EEA19163.1 - 8.4e-23 80.8 0.0 1.2e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Methyltransf_31 PF13847.6 EEA19164.1 - 3.4e-29 101.6 0.0 5.8e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19164.1 - 5.4e-21 75.1 0.0 9.3e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19164.1 - 3.2e-20 72.6 0.0 5.9e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA19164.1 - 4.9e-15 55.5 0.0 2.1e-14 53.4 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EEA19164.1 - 1.4e-10 41.8 0.0 2.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA19164.1 - 1.8e-10 40.9 0.0 2.8e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA19164.1 - 1.5e-09 37.7 0.1 2.3e-09 37.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EEA19164.1 - 2.3e-06 27.3 0.0 3.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EEA19164.1 - 2.7e-06 27.3 0.0 4.7e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 EEA19164.1 - 6.6e-05 22.9 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase CMAS PF02353.20 EEA19164.1 - 0.00019 20.8 0.0 0.00029 20.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase UPF0020 PF01170.18 EEA19164.1 - 0.00034 20.4 0.0 0.00073 19.3 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 DOT1 PF08123.13 EEA19164.1 - 0.0054 16.3 0.0 0.0097 15.5 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 U71 PF17474.2 EEA19164.1 - 0.014 15.3 0.2 0.066 13.1 0.1 2.1 2 0 0 2 2 2 0 Tegument protein UL11 homolog Methyltransf_32 PF13679.6 EEA19164.1 - 0.021 14.8 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EEA19164.1 - 0.11 11.7 0.0 6 6.0 0.0 2.1 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family GidB PF02527.15 EEA19164.1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G HSP70 PF00012.20 EEA19166.1 - 1.7e-09 36.4 0.0 2.6e-08 32.5 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EEA19166.1 - 3.1e-06 26.3 0.0 6e-05 22.0 0.0 2.2 1 1 0 1 1 1 1 MreB/Mbl protein PRELI PF04707.14 EEA19167.1 - 2.7e-25 89.0 0.0 2.3e-22 79.5 0.0 2.1 2 0 0 2 2 2 2 PRELI-like family DUF3896 PF13035.6 EEA19167.1 - 0.19 11.9 0.1 0.62 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Put_DNA-bind_N PF06971.13 EEA19168.1 - 0.026 14.6 0.0 0.51 10.4 0.0 2.6 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus Aminotran_4 PF01063.19 EEA19169.1 - 1.8e-30 106.5 0.0 2.5e-30 106.0 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Fungal_trans_2 PF11951.8 EEA19170.1 - 3.9e-14 52.3 5.1 2.7e-07 29.7 0.8 2.0 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19170.1 - 9.7e-07 28.8 11.3 1.8e-06 27.9 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EEA19171.1 - 8.8e-14 51.5 2.2 0.00019 20.8 0.0 3.3 3 1 0 3 3 3 3 FAD binding domain DAO PF01266.24 EEA19171.1 - 4.1e-11 43.0 0.0 0.00018 21.2 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA19171.1 - 4.7e-10 39.2 0.2 0.00086 18.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA19171.1 - 7.9e-07 28.5 0.3 1.4e-05 24.4 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EEA19171.1 - 4.6e-06 26.8 0.1 3.9e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA19171.1 - 3.4e-05 24.3 0.0 0.016 15.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA19171.1 - 7.2e-05 22.3 0.2 0.00024 20.6 0.2 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA19171.1 - 0.0001 21.2 0.0 0.078 11.7 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.12 EEA19171.1 - 0.00073 18.7 0.2 0.83 8.6 0.0 2.6 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EEA19171.1 - 0.0026 17.1 0.0 0.0087 15.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA19171.1 - 0.015 14.4 0.1 0.88 8.6 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EEA19171.1 - 0.023 14.7 0.3 2.4 8.1 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EEA19171.1 - 0.063 12.1 0.0 7.2 5.3 0.0 2.3 2 0 0 2 2 2 0 Tryptophan halogenase FHA PF00498.26 EEA19172.1 - 4.9e-13 49.2 0.1 9.8e-13 48.3 0.1 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EEA19172.1 - 0.019 15.3 0.0 0.051 13.9 0.0 1.7 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain TAT_signal PF10518.9 EEA19172.1 - 0.38 10.7 1.8 0.76 9.7 1.8 1.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence TPR_1 PF00515.28 EEA19173.1 - 1.2e-37 126.1 26.3 4.3e-08 32.6 0.0 11.8 10 2 1 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 EEA19173.1 - 5.9e-37 122.8 26.3 9.3e-07 28.5 0.0 11.0 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 EEA19173.1 - 1.4e-24 86.5 10.8 1.6e-06 28.6 0.0 7.2 7 1 2 9 9 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 EEA19173.1 - 8e-22 75.6 19.0 4.3e-05 23.4 0.0 10.8 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_17 PF13431.6 EEA19173.1 - 1.5e-20 72.0 9.3 0.0054 17.0 0.0 8.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 EEA19173.1 - 4.4e-20 71.1 24.4 9.4e-08 31.6 0.1 8.3 7 1 1 8 8 8 5 TPR repeat TPR_12 PF13424.6 EEA19173.1 - 6.4e-16 58.4 27.4 0.0031 17.8 1.3 8.3 4 2 3 8 8 8 6 Tetratricopeptide repeat TPR_9 PF13371.6 EEA19173.1 - 9.3e-15 54.5 7.9 7.8e-05 22.7 0.1 6.2 4 1 3 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 EEA19173.1 - 1.5e-14 54.3 20.7 0.00013 22.4 0.4 8.4 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 EEA19173.1 - 2.7e-13 49.5 16.6 0.037 14.8 0.0 9.7 5 2 5 10 10 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 EEA19173.1 - 3.9e-13 48.4 10.6 0.031 14.3 0.1 8.7 9 1 0 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA19173.1 - 3.2e-10 40.1 7.2 0.0056 16.9 0.0 5.5 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EEA19173.1 - 1.8e-05 24.4 20.3 0.76 9.7 0.2 8.8 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA19173.1 - 6.3e-05 22.5 0.3 0.00051 19.5 0.6 3.4 3 2 1 4 4 4 2 MalT-like TPR region SHNi-TPR PF10516.9 EEA19173.1 - 0.00012 21.5 7.9 1.8 8.1 0.1 6.2 6 0 0 6 6 6 1 SHNi-TPR IPPT PF01715.17 EEA19173.1 - 0.0033 17.3 3.2 0.051 13.4 0.3 3.0 2 1 0 3 3 3 1 IPP transferase DUF2397 PF09660.10 EEA19173.1 - 0.0052 15.7 1.3 0.0052 15.7 1.3 1.9 3 0 0 3 3 3 1 Protein of unknown function (DUF2397) MAS20 PF02064.15 EEA19173.1 - 0.0056 16.8 10.9 0.13 12.4 1.9 4.1 4 1 0 4 4 4 1 MAS20 protein import receptor AP3D1 PF06375.11 EEA19173.1 - 0.0076 16.5 4.7 0.018 15.3 4.7 1.6 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 DUF2681 PF10883.8 EEA19173.1 - 0.0095 16.3 0.8 0.031 14.7 0.8 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) TSGP1 PF07771.11 EEA19173.1 - 0.022 14.9 0.2 0.048 13.8 0.2 1.5 1 0 0 1 1 1 0 Tick salivary peptide group 1 TPR_4 PF07721.14 EEA19173.1 - 0.026 15.1 3.1 28 5.7 0.2 4.8 5 0 0 5 5 3 0 Tetratricopeptide repeat DUF2561 PF10812.8 EEA19173.1 - 0.11 12.5 0.6 0.21 11.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) BCIP PF13862.6 EEA19173.1 - 0.11 12.2 1.4 13 5.5 0.0 2.5 2 0 0 2 2 2 0 p21-C-terminal region-binding protein U1snRNP70_N PF12220.8 EEA19173.1 - 0.81 10.4 7.7 0.11 13.1 2.0 2.6 3 0 0 3 3 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3856 PF12968.7 EEA19173.1 - 0.9 9.6 9.3 4 7.5 0.0 5.1 5 1 1 6 6 6 0 Domain of Unknown Function (DUF3856) Usp PF00582.26 EEA19173.1 - 1.3 9.6 8.6 1.9 9.0 3.1 3.4 3 1 0 3 3 3 0 Universal stress protein family Sel1 PF08238.12 EEA19173.1 - 3.1 8.6 8.7 13 6.6 0.2 4.0 4 0 0 4 4 2 0 Sel1 repeat NARP1 PF12569.8 EEA19173.1 - 6.9 5.5 26.8 9.9 4.9 0.1 4.9 3 1 2 5 5 5 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 EEA19173.1 - 8.7 7.2 32.8 40 5.1 0.7 9.2 10 0 0 10 10 9 0 Tetratricopeptide repeat Abhydrolase_2 PF02230.16 EEA19174.1 - 1.3e-21 77.4 0.8 1.2e-09 38.3 0.0 4.0 3 1 0 4 4 4 4 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EEA19174.1 - 0.075 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA19174.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA19175.1 - 1.3e-21 77.4 0.8 1.2e-09 38.3 0.0 4.0 3 1 0 4 4 4 4 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EEA19175.1 - 0.075 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA19175.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA19176.1 - 1.3e-21 77.4 0.8 1.2e-09 38.3 0.0 4.0 3 1 0 4 4 4 4 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EEA19176.1 - 0.075 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA19176.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 FA_desaturase PF00487.24 EEA19177.1 - 3.3e-16 59.9 22.4 3.3e-16 59.9 22.4 1.7 1 1 1 2 2 2 1 Fatty acid desaturase Sec1 PF00995.23 EEA19178.1 - 1.2e-126 424.3 0.0 1.4e-126 424.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family HCV_core PF01542.18 EEA19178.1 - 0.083 13.3 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus core protein DUF1043 PF06295.12 EEA19178.1 - 0.3 11.1 1.7 0.52 10.3 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) zf_CCCH_4 PF18345.1 EEA19179.1 - 6.4e-06 26.0 3.7 1.1e-05 25.3 3.7 1.4 1 0 0 1 1 1 1 Zinc finger domain 14-3-3 PF00244.20 EEA19179.1 - 0.0084 15.6 0.4 0.016 14.7 0.4 1.4 1 0 0 1 1 1 1 14-3-3 protein Torus PF16131.5 EEA19179.1 - 0.01 16.5 0.1 0.041 14.6 0.1 2.0 1 0 0 1 1 1 0 Torus domain zf-CCCH_4 PF18044.1 EEA19179.1 - 0.011 15.5 1.9 0.017 14.9 1.9 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EEA19179.1 - 0.019 15.2 0.2 0.059 13.6 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger containing family zf-CCCH PF00642.24 EEA19179.1 - 0.035 14.0 1.1 0.055 13.4 1.1 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EEA19179.1 - 0.13 12.7 1.3 0.23 12.0 1.3 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger CedA PF10729.9 EEA19179.1 - 0.5 10.3 3.5 0.24 11.3 0.1 2.3 2 0 0 2 2 2 0 Cell division activator CedA AT_hook PF02178.19 EEA19179.1 - 0.54 10.3 6.2 2.3 8.4 6.2 2.2 1 0 0 1 1 1 0 AT hook motif DUF218 PF02698.17 EEA19180.1 - 8.8e-06 25.8 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 DUF218 domain HORMA PF02301.18 EEA19181.1 - 1.3e-33 116.4 0.0 1.5e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 HORMA domain DUF3530 PF12048.8 EEA19181.1 - 0.018 14.5 1.9 0.031 13.7 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Peptidase_C13 PF01650.18 EEA19181.1 - 0.022 14.3 0.1 0.031 13.8 0.1 1.2 1 0 0 1 1 1 0 Peptidase C13 family DUF2660 PF10859.8 EEA19181.1 - 0.045 14.2 0.0 0.15 12.5 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) Arcadin_1 PF18653.1 EEA19181.1 - 0.081 13.0 0.0 11 6.2 0.0 2.2 2 0 0 2 2 2 0 Arcadin 1 GTP_EFTU PF00009.27 EEA19182.1 - 7.6e-50 169.2 0.0 1.2e-49 168.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EEA19182.1 - 1.3e-42 144.3 4.0 2.4e-42 143.4 4.0 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EEA19182.1 - 4.9e-17 61.7 0.0 8.9e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EEA19182.1 - 3.1e-06 27.5 0.0 7e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 EEA19182.1 - 1.6e-05 24.6 0.0 0.00027 20.6 0.0 2.3 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 EEA19182.1 - 4e-05 23.7 0.0 0.0001 22.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EEA19182.1 - 0.0077 16.3 0.0 0.017 15.2 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.10 EEA19182.1 - 0.0093 15.4 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RF3_C PF16658.5 EEA19182.1 - 0.016 15.1 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Opy2 PF09463.10 EEA19184.1 - 5.2e-05 23.5 24.1 8.4e-05 22.8 24.1 1.4 1 0 0 1 1 1 1 Opy2 protein LapA_dom PF06305.11 EEA19184.1 - 0.29 11.0 2.5 0.64 9.9 2.5 1.5 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Rad51 PF08423.11 EEA19185.1 - 0.00098 18.4 0.0 0.0025 17.1 0.0 1.7 1 1 0 1 1 1 1 Rad51 Lactamase_B PF00753.27 EEA19186.1 - 8.7e-17 61.8 0.3 1.1e-16 61.4 0.3 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA19186.1 - 0.0085 15.6 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain NmrA PF05368.13 EEA19187.1 - 1.9e-26 93.1 0.3 2.3e-26 92.8 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA19187.1 - 8.7e-18 64.9 0.0 1.7e-17 63.9 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EEA19187.1 - 1.6e-06 27.8 0.3 4.9e-06 26.2 0.1 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EEA19187.1 - 0.00059 20.1 0.1 0.0022 18.3 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 EEA19187.1 - 0.0018 17.8 0.1 0.0038 16.7 0.1 1.6 1 0 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.20 EEA19187.1 - 0.01 15.9 0.2 0.022 14.9 0.2 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_7 PF13241.6 EEA19187.1 - 0.01 16.2 0.1 0.023 15.1 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 EEA19187.1 - 0.016 15.1 0.3 0.027 14.4 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 EEA19187.1 - 0.023 15.1 0.2 0.056 13.9 0.2 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EEA19187.1 - 0.024 13.8 0.0 0.04 13.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain THF_DHG_CYH_C PF02882.19 EEA19187.1 - 0.024 14.0 0.5 0.066 12.5 0.4 1.9 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DXP_reductoisom PF02670.16 EEA19187.1 - 0.031 15.0 1.0 0.11 13.2 0.2 2.3 3 0 0 3 3 3 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase GDP_Man_Dehyd PF16363.5 EEA19187.1 - 0.061 12.7 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 EEA19187.1 - 0.17 11.2 0.1 0.4 10.0 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Abhydrolase_6 PF12697.7 EEA19188.1 - 3.1e-20 73.7 1.6 3.7e-20 73.5 1.6 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19188.1 - 0.0079 15.5 0.1 0.022 14.0 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA19188.1 - 0.036 13.7 0.1 0.071 12.7 0.1 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA19188.1 - 0.075 12.7 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF3224 PF11528.8 EEA19189.1 - 1.1e-28 99.6 0.0 1.3e-28 99.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3224) Mitochondr_Som1 PF11093.8 EEA19190.1 - 4.4e-24 84.3 0.0 5.6e-24 84.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial export protein Som1 TAF8_C PF10406.9 EEA19191.1 - 3.6e-21 75.5 0.5 9.4e-21 74.1 0.5 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EEA19191.1 - 2.1e-11 43.7 0.0 3.7e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated COX6C PF02937.15 EEA19192.1 - 0.0075 16.4 0.0 0.0085 16.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc DUF4233 PF14017.6 EEA19192.1 - 0.12 12.7 0.0 0.13 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4233) UQ_con PF00179.26 EEA19193.1 - 2.3e-38 131.0 0.0 3e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA19193.1 - 0.041 13.6 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Chitin_synth_1 PF01644.17 EEA19194.1 - 8.9e-71 237.1 0.0 3.4e-70 235.2 0.0 1.8 2 0 0 2 2 2 1 Chitin synthase Chitin_synth_1N PF08407.11 EEA19194.1 - 2.3e-28 97.9 0.0 4.5e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EEA19194.1 - 2.3e-25 89.2 0.1 1.7e-20 73.2 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EEA19194.1 - 2.6e-09 37.3 0.1 2.6e-09 37.3 0.1 2.6 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EEA19194.1 - 0.00018 21.5 0.0 0.00045 20.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PALP PF00291.25 EEA19195.1 - 1.9e-69 234.4 0.1 2.3e-69 234.0 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 EEA19195.1 - 0.0021 18.0 0.1 2.5 8.1 0.0 2.4 2 0 0 2 2 2 2 Zinc-binding dehydrogenase DegT_DnrJ_EryC1 PF01041.17 EEA19195.1 - 0.1 11.9 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family IlvN PF07991.12 EEA19196.1 - 9.9e-46 155.3 0.0 1.5e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EEA19196.1 - 2.7e-40 138.0 0.0 4e-40 137.4 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 EEA19196.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EEA19196.1 - 0.16 12.6 0.0 0.34 11.5 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2OG-FeII_Oxy_2 PF13532.6 EEA19197.1 - 8.3e-27 94.7 0.0 1.5e-26 93.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 EEA19197.1 - 2.2e-20 73.5 0.0 7e-20 71.9 0.0 1.8 1 1 0 1 1 1 1 Isochorismatase family GST_C PF00043.25 EEA19197.1 - 2.9e-05 24.2 0.0 8e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA19197.1 - 7.2e-05 22.9 0.0 0.00016 21.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA19197.1 - 0.0009 19.2 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ECH_1 PF00378.20 EEA19198.1 - 1.9e-36 125.7 0.0 9.7e-36 123.3 0.0 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA19198.1 - 1.1e-29 104.0 0.0 6.5e-28 98.2 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DNA_pol3_theta PF06440.11 EEA19198.1 - 0.13 11.9 0.0 0.82 9.4 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III, theta subunit Tfb5 PF06331.12 EEA19199.1 - 1.4e-24 85.8 0.7 1.6e-24 85.7 0.7 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 HSP20 PF00011.21 EEA19200.1 - 1.2e-19 70.3 0.2 3.7e-14 52.7 0.1 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EEA19200.1 - 4e-08 32.7 0.0 0.0038 16.8 0.0 2.5 2 0 0 2 2 2 2 HSP20-like domain found in ArsA MFS_1 PF07690.16 EEA19201.1 - 1.5e-42 145.8 43.1 1.5e-42 145.8 43.1 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19201.1 - 6.4e-11 41.8 11.3 6.4e-11 41.8 11.3 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EEA19201.1 - 3.2e-09 36.6 3.6 3.2e-09 36.6 3.6 2.7 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB PUCC PF03209.15 EEA19201.1 - 3.2e-05 23.1 21.0 0.00017 20.7 3.8 2.8 2 1 0 2 2 2 2 PUCC protein OATP PF03137.20 EEA19201.1 - 0.00064 18.1 10.7 0.0026 16.1 1.7 2.5 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Glyco_hydro_53 PF07745.13 EEA19202.1 - 3.8e-102 341.8 0.0 4.3e-102 341.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 SLC35F PF06027.12 EEA19203.1 - 4e-91 305.7 29.0 4.6e-91 305.4 29.0 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EEA19203.1 - 8.1e-09 34.9 6.1 1.7e-08 33.8 6.1 1.6 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EEA19203.1 - 0.0027 17.9 40.7 0.0069 16.6 14.5 2.3 2 0 0 2 2 2 2 EamA-like transporter family Ank_2 PF12796.7 EEA19204.1 - 5e-24 84.7 2.3 3.9e-12 46.6 0.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA19204.1 - 5.8e-16 57.0 1.3 8.7e-05 22.6 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EEA19204.1 - 1.7e-14 53.9 1.1 6.5e-10 39.3 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA19204.1 - 3.3e-11 43.2 1.1 4.5e-06 26.8 0.1 3.8 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA19204.1 - 1.7e-10 40.9 0.5 0.00052 20.3 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeat F-box PF00646.33 EEA19204.1 - 0.013 15.4 2.0 0.15 12.0 0.4 2.4 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EEA19204.1 - 0.15 12.0 1.1 0.81 9.6 0.4 2.2 2 0 0 2 2 2 0 F-box-like Acetyltransf_1 PF00583.25 EEA19205.1 - 2.6e-09 37.3 0.0 4.5e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA19205.1 - 1.2e-08 34.9 0.0 7.1e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA19205.1 - 1.1e-07 32.2 0.0 9e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA19205.1 - 0.00055 20.0 0.0 0.02 15.0 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EEA19206.1 - 6.4e-41 140.5 0.0 9.8e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19206.1 - 4.4e-22 78.6 0.0 6.8e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA19206.1 - 0.01 15.1 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 0 Kinase-like CMD PF02627.20 EEA19207.1 - 2e-06 27.7 0.0 4.7e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Lactonase PF10282.9 EEA19208.1 - 2.1e-22 79.9 0.0 2.8e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Frag1 PF10277.9 EEA19209.1 - 6.7e-24 84.6 15.2 8e-24 84.4 15.2 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Phage_C PF12025.8 EEA19209.1 - 0.12 12.2 0.0 0.38 10.6 0.0 1.8 2 0 0 2 2 2 0 Phage protein C Acetyltransf_10 PF13673.7 EEA19211.1 - 9.7e-07 28.8 0.0 5e-06 26.5 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA19211.1 - 5.5e-06 26.6 0.0 1e-05 25.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EEA19211.1 - 0.0001 22.2 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EEA19211.1 - 0.00012 22.5 0.0 0.00023 21.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain p450 PF00067.22 EEA19212.1 - 2e-52 178.5 0.0 2.5e-52 178.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_3_C PF01915.22 EEA19214.1 - 1e-49 169.3 0.1 1.8e-49 168.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA19214.1 - 9.3e-36 123.8 0.0 1.9e-35 122.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA19214.1 - 5e-21 74.6 0.0 1.1e-20 73.5 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF4504 PF14953.6 EEA19215.1 - 0.046 13.1 0.1 0.059 12.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) Catalase PF00199.19 EEA19216.1 - 2.4e-163 543.7 0.0 3e-163 543.4 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase_C PF18011.1 EEA19216.1 - 1.1e-47 161.5 1.6 1.8e-47 160.8 1.6 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 EEA19216.1 - 4e-14 52.6 0.0 7.4e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive DUF3727 PF12527.8 EEA19216.1 - 0.2 11.9 0.0 15 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3727) MFS_1 PF07690.16 EEA19217.1 - 2.2e-09 36.7 33.0 2.2e-09 36.7 33.0 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EEA19217.1 - 1.7e-05 24.6 5.2 1.7e-05 24.6 5.2 2.6 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EEA19218.1 - 5.3e-97 325.5 27.1 6.1e-97 325.3 27.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19218.1 - 1.4e-23 83.4 27.8 1.4e-23 83.4 27.8 2.3 2 1 1 3 3 3 1 Major Facilitator Superfamily Transferase PF02458.15 EEA19219.1 - 4.2e-05 22.4 0.1 0.013 14.2 0.0 3.0 3 1 0 3 3 3 2 Transferase family ZapB PF06005.12 EEA19220.1 - 0.00016 22.1 10.3 0.006 17.0 10.3 2.3 1 1 0 1 1 1 1 Cell division protein ZapB GAS PF13851.6 EEA19220.1 - 0.00023 20.6 6.6 0.00035 20.0 6.6 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 EEA19220.1 - 0.00082 18.8 0.6 0.0014 18.0 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) HemX PF04375.14 EEA19220.1 - 0.0071 15.7 2.2 0.01 15.1 2.2 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase KASH_CCD PF14662.6 EEA19220.1 - 0.012 15.4 6.5 0.019 14.8 6.5 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TMF_TATA_bd PF12325.8 EEA19220.1 - 0.014 15.6 4.6 0.026 14.7 4.6 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 EEA19220.1 - 0.014 15.1 6.5 0.36 10.6 1.4 2.3 1 1 1 2 2 2 0 Septum formation initiator Spc7 PF08317.11 EEA19220.1 - 0.014 14.3 3.3 0.028 13.3 3.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 EEA19220.1 - 0.016 15.5 2.6 0.06 13.7 2.8 1.8 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 EEA19220.1 - 0.024 14.6 1.5 0.046 13.7 1.5 1.4 1 0 0 1 1 1 0 Laminin Domain II Rubredoxin PF00301.20 EEA19220.1 - 0.081 13.0 1.2 0.18 11.8 1.2 1.6 1 0 0 1 1 1 0 Rubredoxin DUF1664 PF07889.12 EEA19220.1 - 0.1 12.6 0.4 0.18 11.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 EEA19220.1 - 0.12 12.5 7.9 1.3 9.2 2.3 2.5 1 1 1 2 2 2 0 bZIP transcription factor APG6_N PF17675.1 EEA19220.1 - 0.16 12.5 8.9 0.26 11.8 8.9 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region ATG16 PF08614.11 EEA19220.1 - 0.17 12.1 15.9 0.044 14.0 12.9 1.4 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Phage_GP20 PF06810.11 EEA19220.1 - 0.18 11.6 5.0 0.85 9.4 3.2 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 Occludin_ELL PF07303.13 EEA19220.1 - 0.22 12.2 1.8 0.49 11.2 1.8 1.6 1 0 0 1 1 1 0 Occludin homology domain HALZ PF02183.18 EEA19220.1 - 0.32 11.2 10.0 0.45 10.8 2.6 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper TMF_DNA_bd PF12329.8 EEA19220.1 - 0.36 10.8 8.8 1.2 9.2 8.5 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Cnn_1N PF07989.11 EEA19220.1 - 0.5 10.6 5.9 1.5 9.1 5.6 2.0 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 bZIP_2 PF07716.15 EEA19220.1 - 0.55 10.4 8.6 1.6 8.8 3.1 2.4 1 1 1 2 2 2 0 Basic region leucine zipper GIT_CC PF16559.5 EEA19220.1 - 0.69 9.8 3.8 1.2 9.0 0.3 2.5 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Syntaxin-6_N PF09177.11 EEA19220.1 - 0.8 10.3 6.0 14 6.3 2.3 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CENP-H PF05837.12 EEA19220.1 - 2.2 8.7 8.6 0.13 12.7 2.6 2.0 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Atg14 PF10186.9 EEA19220.1 - 3.6 6.6 11.7 0.12 11.4 5.0 1.8 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5595 PF18077.1 EEA19220.1 - 4.1 7.6 6.0 2.5 8.2 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) WD40_alt PF14077.6 EEA19220.1 - 4.7 7.2 6.1 4.4 7.3 0.5 2.4 2 0 0 2 2 2 0 Alternative WD40 repeat motif MnhB PF04039.13 EEA19221.1 - 1.8 8.9 11.6 1.2 9.5 0.3 2.8 2 1 1 3 3 3 0 Domain related to MnhB subunit of Na+/H+ antiporter FAD_binding_4 PF01565.23 EEA19222.1 - 7.1e-20 71.2 0.3 1.4e-19 70.2 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA19222.1 - 0.0011 19.0 1.5 0.0017 18.4 0.2 2.1 2 0 0 2 2 2 1 Berberine and berberine like p450 PF00067.22 EEA19223.1 - 3.6e-56 190.9 0.0 4.2e-56 190.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2_assoc2 PF16624.5 EEA19226.1 - 0.59 11.2 7.2 1.3 10.0 7.2 1.5 1 0 0 1 1 1 0 Unstructured region upstream of a zinc-finger ORC6 PF05460.13 EEA19226.1 - 0.63 9.2 8.1 3.9 6.7 3.5 2.1 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) DUF908 PF06012.12 EEA19226.1 - 1.1 8.5 5.3 1.6 8.0 5.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) MFS_1 PF07690.16 EEA19227.1 - 4.6e-34 117.9 27.0 4.6e-34 117.9 27.0 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily CoA_trans PF01144.23 EEA19228.1 - 5.5e-103 343.0 1.4 2.5e-62 210.1 0.1 2.1 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 EEA19228.1 - 0.00015 21.7 0.0 0.0004 20.3 0.0 1.7 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Mannitol_dh_C PF08125.13 EEA19228.1 - 0.11 11.9 0.1 0.63 9.5 0.0 2.0 2 0 0 2 2 2 0 Mannitol dehydrogenase C-terminal domain Zn_clus PF00172.18 EEA19229.1 - 7.2e-05 22.8 7.1 0.00016 21.7 7.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vir_act_alpha_C PF10400.9 EEA19229.1 - 0.13 13.0 0.1 1.2 9.8 0.0 2.4 2 0 0 2 2 2 0 Virulence activator alpha C-term Lactamase_B PF00753.27 EEA19230.1 - 4.3e-17 62.8 0.9 7.2e-17 62.0 0.9 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA19230.1 - 0.00022 20.8 0.1 0.0004 20.0 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Pyr_redox_2 PF07992.14 EEA19231.1 - 2.6e-12 46.6 0.0 2.7e-09 36.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA19231.1 - 0.002 18.2 0.0 0.013 15.5 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EEA19231.1 - 0.0029 17.3 0.3 0.005 16.5 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA19231.1 - 0.037 13.1 0.2 0.086 11.9 0.2 1.6 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 EEA19231.1 - 0.094 11.8 0.0 0.19 10.8 0.0 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EEA19231.1 - 0.096 11.9 0.1 0.8 8.9 0.0 2.2 2 1 1 3 3 3 0 FAD binding domain NAD_binding_8 PF13450.6 EEA19231.1 - 0.11 12.7 0.1 0.25 11.6 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain cobW PF02492.19 EEA19232.1 - 4.3e-49 166.5 8.9 1.4e-36 125.8 0.2 2.6 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EEA19232.1 - 3.2e-20 71.8 0.1 2.1e-15 56.4 0.0 2.6 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain GTP_EFTU PF00009.27 EEA19232.1 - 0.00067 19.2 0.1 0.081 12.5 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EEA19232.1 - 0.0078 16.6 0.4 0.041 14.3 0.4 2.3 1 1 0 1 1 1 1 AAA ATPase domain MobB PF03205.14 EEA19232.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 EEA19232.1 - 0.03 13.3 5.9 1.7 7.6 0.0 3.5 3 1 1 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EEA19232.1 - 0.043 14.3 1.4 0.23 12.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 EEA19232.1 - 0.056 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Serine_rich PF08824.10 EEA19232.1 - 0.063 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Serine rich protein interaction domain T2SSE PF00437.20 EEA19232.1 - 0.084 11.9 0.7 0.19 10.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_33 PF13671.6 EEA19232.1 - 0.086 13.0 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EEA19232.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 EEA19232.1 - 0.16 11.8 0.1 0.4 10.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA19232.1 - 0.37 11.3 2.5 1.4 9.4 0.1 2.6 3 0 0 3 3 3 0 AAA domain TauD PF02668.16 EEA19233.1 - 2.2e-51 175.2 0.0 2.5e-51 175.0 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans PF04082.18 EEA19234.1 - 1e-13 50.9 0.1 1.7e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19234.1 - 5.6e-08 32.8 11.5 1.2e-07 31.8 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA19235.1 - 4.9e-29 101.4 51.4 3.3e-22 78.9 22.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SURF4 PF02077.15 EEA19235.1 - 0.0085 15.7 0.1 0.0085 15.7 0.1 2.1 3 0 0 3 3 3 1 SURF4 family PBP PF01161.20 EEA19236.1 - 7.2e-07 29.6 0.2 1.1e-06 29.0 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein CMAS PF02353.20 EEA19237.1 - 1.2e-77 260.9 0.0 1.8e-77 260.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EEA19237.1 - 1.1e-14 54.8 0.0 2.5e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19237.1 - 1.3e-13 51.4 0.0 3.4e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA19237.1 - 6.1e-12 45.7 0.0 1.3e-11 44.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19237.1 - 8.7e-08 32.1 0.0 1.8e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA19237.1 - 1e-07 32.6 0.0 2.8e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EEA19237.1 - 1.5e-05 24.6 0.0 2.9e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 EEA19237.1 - 7.8e-05 22.3 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EEA19237.1 - 0.00074 19.3 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 EEA19237.1 - 0.003 17.5 0.0 0.0054 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EEA19237.1 - 0.063 12.6 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_9 PF08003.11 EEA19237.1 - 0.074 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_4 PF02390.17 EEA19237.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase SUR7 PF06687.12 EEA19238.1 - 7.6e-42 143.3 10.0 9e-42 143.1 10.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family Phage_tail_3 PF08813.11 EEA19238.1 - 0.028 14.0 0.3 0.079 12.6 0.2 1.8 2 0 0 2 2 2 0 Phage tail tube protein, TTP Sigma_reg_N PF13800.6 EEA19238.1 - 0.37 11.1 0.0 0.37 11.1 0.0 2.7 2 1 1 3 3 3 0 Sigma factor regulator N-terminal Peptidase_S41 PF03572.18 EEA19239.1 - 1.4e-06 28.0 0.0 5.7e-06 26.0 0.0 2.1 2 1 0 2 2 2 1 Peptidase family S41 MFS_1 PF07690.16 EEA19240.1 - 1.3e-40 139.4 62.9 1.3e-39 136.1 62.6 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF1422 PF07226.11 EEA19240.1 - 0.082 12.9 5.0 0.39 10.7 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1422) UcrQ PF02939.16 EEA19241.1 - 1.9e-33 114.2 0.2 2.2e-33 114.0 0.2 1.0 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 EEA19241.1 - 0.0068 16.8 0.0 0.0088 16.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 UcrQ PF02939.16 EEA19242.1 - 4.8e-33 112.9 0.2 6.5e-33 112.5 0.2 1.2 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 EEA19242.1 - 0.011 16.2 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 UcrQ PF02939.16 EEA19243.1 - 1.7e-26 91.9 0.6 2e-26 91.7 0.6 1.0 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 EEA19243.1 - 0.007 16.7 0.0 0.0091 16.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 adh_short PF00106.25 EEA19244.1 - 9.1e-23 80.7 0.0 4.9e-22 78.3 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19244.1 - 1.1e-11 44.8 0.0 2.2e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19244.1 - 1.9e-09 37.7 0.0 2.5e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA19244.1 - 1.1e-06 28.3 0.0 1.8e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA19244.1 - 0.00041 19.9 0.0 0.002 17.6 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Methyltransf_2 PF00891.18 EEA19244.1 - 0.068 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain DUF3425 PF11905.8 EEA19245.1 - 6.1e-18 65.0 0.3 6.1e-18 65.0 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) HTH_15 PF12324.8 EEA19245.1 - 0.13 12.3 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase FMN_red PF03358.15 EEA19246.1 - 2.6e-25 88.9 0.0 3.4e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EEA19246.1 - 9.5e-05 22.2 0.1 0.00016 21.4 0.1 1.3 1 1 0 1 1 1 1 Flavodoxin-like fold Rz1 PF06085.11 EEA19246.1 - 0.043 13.6 0.1 0.079 12.7 0.1 1.4 1 0 0 1 1 1 0 Lipoprotein Rz1 precursor EP400_N PF15790.5 EEA19246.1 - 0.055 12.3 0.0 0.5 9.1 0.0 1.9 2 0 0 2 2 2 0 E1A-binding protein p400, N-terminal Fungal_trans PF04082.18 EEA19247.1 - 2.6e-19 69.3 2.4 4.6e-19 68.5 2.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19247.1 - 1.3e-09 38.0 9.2 2.8e-09 37.0 9.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1280 PF06918.14 EEA19247.1 - 0.02 14.5 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) Phosphoesterase PF04185.14 EEA19248.1 - 1.5e-31 109.9 3.7 1.4e-30 106.7 3.6 2.0 1 1 0 1 1 1 1 Phosphoesterase family MBOAT_2 PF13813.6 EEA19248.1 - 3e-19 69.1 4.7 8.9e-19 67.6 4.7 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Sulfatase PF00884.23 EEA19248.1 - 0.0088 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Transp_cyt_pur PF02133.15 EEA19250.1 - 6.5e-19 68.0 39.0 6.4e-18 64.8 38.9 2.4 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Fzo_mitofusin PF04799.13 EEA19250.1 - 1.1 8.8 2.1 1.8 8.1 2.1 1.3 1 0 0 1 1 1 0 fzo-like conserved region 2OG-FeII_Oxy_3 PF13640.6 EEA19251.1 - 5.3e-10 40.1 0.1 1e-09 39.2 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Thioredoxin_6 PF13848.6 EEA19252.1 - 2.3e-17 63.5 0.0 3.5e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.20 EEA19252.1 - 4e-09 36.4 0.0 2.3e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin DUF727 PF05303.12 EEA19252.1 - 0.11 12.6 0.0 6.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF727) Transferase PF02458.15 EEA19254.1 - 3.5e-26 91.8 0.0 5.9e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Transferase family DUF3475 PF11961.8 EEA19254.1 - 0.054 13.6 0.0 0.53 10.4 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3475) NmrA PF05368.13 EEA19255.1 - 1.1e-22 80.8 0.1 2.6e-22 79.6 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA19255.1 - 1.6e-18 67.3 0.0 4.5e-18 65.8 0.0 1.7 1 1 1 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EEA19255.1 - 4.4e-07 30.2 0.1 2e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EEA19255.1 - 3.7e-05 24.2 0.1 0.00027 21.4 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EEA19255.1 - 0.0029 16.9 0.7 0.05 12.9 0.7 2.2 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DapB_N PF01113.20 EEA19255.1 - 0.0039 17.3 0.6 0.017 15.3 0.1 2.2 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EEA19255.1 - 0.0051 16.3 0.0 0.039 13.4 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EEA19255.1 - 0.0092 16.0 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 EEA19255.1 - 0.13 11.4 0.1 0.42 9.7 0.0 1.9 3 0 0 3 3 3 0 Male sterility protein Fungal_trans PF04082.18 EEA19256.1 - 2.5e-12 46.4 0.0 3.8e-12 45.8 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain RPA_interact_N PF14766.6 EEA19256.1 - 0.0089 15.6 0.6 0.02 14.5 0.6 1.6 1 0 0 1 1 1 1 Replication protein A interacting N-terminal Glyco_trans_2_3 PF13632.6 EEA19257.1 - 6.3e-39 133.9 1.4 1.1e-38 133.1 1.4 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Ank_2 PF12796.7 EEA19259.1 - 1.5e-45 153.7 7.0 2.1e-10 41.0 0.5 5.9 3 2 0 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19259.1 - 1.4e-43 146.7 14.1 2.7e-06 27.8 0.0 12.1 3 3 9 13 13 13 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19259.1 - 3.5e-34 113.0 15.2 0.00027 21.1 0.0 14.2 15 0 0 15 15 15 6 Ankyrin repeat Ank_5 PF13857.6 EEA19259.1 - 8.6e-33 112.0 15.0 9.6e-05 22.6 0.0 9.9 6 2 5 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 EEA19259.1 - 2.9e-22 78.0 20.5 0.013 15.9 0.0 13.1 13 1 0 13 13 13 5 Ankyrin repeat DUF2773 PF10971.8 EEA19259.1 - 0.034 14.3 0.6 16 5.7 0.0 3.8 4 1 1 5 5 5 0 Protein of unknown function (DUF2773) RVT_2 PF07727.14 EEA19261.1 - 2.4e-10 40.5 0.0 4.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA19261.1 - 3.7e-09 36.8 0.4 1.6e-08 34.8 0.1 2.4 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EEA19261.1 - 5.1e-06 26.3 1.1 1.7e-05 24.6 1.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Peptidase_S8 PF00082.22 EEA19263.1 - 6.8e-08 32.1 0.0 0.0056 16.0 0.0 2.7 2 1 1 3 3 3 2 Subtilase family Ank_2 PF12796.7 EEA19263.1 - 0.00013 22.5 0.0 1.7 9.3 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EEA19263.1 - 0.0062 16.9 0.0 2.9 8.5 0.0 3.7 3 1 0 3 3 3 1 Ankyrin repeat Gemini_AL1_M PF08283.11 EEA19263.1 - 0.0078 16.3 0.0 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 Geminivirus rep protein central domain Ank_4 PF13637.6 EEA19263.1 - 0.037 14.6 0.0 2.2 9.0 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Tfb2_C PF18307.1 EEA19263.1 - 0.051 14.0 0.0 4.6 7.7 0.0 2.7 2 0 0 2 2 2 0 Transcription factor Tfb2 (p52) C-terminal domain Ank_3 PF13606.6 EEA19263.1 - 0.1 13.2 0.0 33 5.5 0.0 4.2 4 0 0 4 4 4 0 Ankyrin repeat adh_short PF00106.25 EEA19264.1 - 3.4e-26 91.9 0.0 4.6e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19264.1 - 7.5e-18 64.9 0.0 9.4e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19264.1 - 5.6e-06 26.4 0.0 7.6e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Semialdhyde_dh PF01118.24 EEA19264.1 - 0.075 13.5 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EEA19264.1 - 0.086 12.2 0.0 0.85 9.0 0.0 2.4 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EEA19264.1 - 0.096 12.1 0.0 0.27 10.7 0.0 1.8 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family ABC_tran PF00005.27 EEA19265.1 - 3.1e-30 105.5 0.0 4.7e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EEA19265.1 - 0.00013 21.9 0.8 0.24 11.2 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA19265.1 - 0.00067 19.2 3.4 0.014 14.8 3.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA19265.1 - 0.011 16.0 0.2 0.039 14.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 EEA19265.1 - 0.016 15.3 0.4 0.053 13.6 0.1 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_29 PF13555.6 EEA19265.1 - 0.032 14.0 0.1 0.065 13.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EEA19265.1 - 0.033 13.0 0.2 0.033 13.0 0.2 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class MMR_HSR1 PF01926.23 EEA19265.1 - 0.04 14.0 0.0 0.093 12.8 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase MeaB PF03308.16 EEA19265.1 - 0.14 11.1 0.1 0.22 10.5 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EEA19265.1 - 0.14 12.1 0.4 0.3 11.0 0.1 1.6 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 EEA19265.1 - 0.15 12.6 0.0 4.2 7.9 0.0 2.5 1 1 1 2 2 2 0 AAA domain AAA_23 PF13476.6 EEA19265.1 - 0.19 12.2 2.4 0.47 10.9 2.4 1.8 1 1 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 EEA19266.1 - 8.9e-26 91.1 25.6 3.4e-18 66.3 7.9 3.1 2 1 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA19266.1 - 4.8e-17 62.8 0.0 1.2e-16 61.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EEA19266.1 - 1.5e-05 24.5 0.0 0.014 14.9 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA19266.1 - 3.8e-05 23.3 0.1 0.00014 21.5 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EEA19266.1 - 0.00069 19.5 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 EEA19266.1 - 0.0031 16.6 0.2 0.0065 15.6 0.2 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EEA19266.1 - 0.0035 17.6 0.1 0.014 15.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 EEA19266.1 - 0.0049 15.7 0.5 1.2 7.9 0.1 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 EEA19266.1 - 0.025 15.1 0.1 0.049 14.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA19266.1 - 0.027 14.8 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EEA19266.1 - 0.032 14.1 0.1 0.064 13.2 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase Dynamin_N PF00350.23 EEA19266.1 - 0.06 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Dynamin family cobW PF02492.19 EEA19266.1 - 0.089 12.4 0.2 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EEA19266.1 - 0.13 11.8 0.1 0.34 10.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EEA19266.1 - 0.16 11.6 0.1 0.29 10.8 0.1 1.3 1 0 0 1 1 1 0 AAA ATPase domain Retrotran_gag_2 PF14223.6 EEA19267.1 - 7.6e-16 58.0 0.2 1.2e-15 57.4 0.2 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EEA19267.1 - 2.2e-10 39.9 0.2 4.9e-10 38.8 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) zf-CCHC PF00098.23 EEA19267.1 - 3.9e-06 26.7 1.7 3.9e-06 26.7 1.7 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_6 PF15288.6 EEA19267.1 - 0.025 14.4 1.3 0.055 13.3 1.3 1.5 1 0 0 1 1 1 0 Zinc knuckle CAF1A PF12253.8 EEA19267.1 - 0.032 14.4 1.2 0.074 13.2 0.3 2.1 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A zf-CCHC_4 PF14392.6 EEA19267.1 - 0.15 11.9 1.9 1.1 9.0 0.3 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-C2HE PF16278.5 EEA19267.1 - 0.15 12.5 0.0 0.59 10.6 0.0 2.0 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger ADH_N_assoc PF13823.6 EEA19267.1 - 0.41 10.6 4.1 50 3.9 0.1 3.6 3 0 0 3 3 3 0 Alcohol dehydrogenase GroES-associated HscB_4_cys PF18256.1 EEA19267.1 - 0.62 9.9 2.7 1.5 8.7 2.7 1.6 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif DUF3035 PF11233.8 EEA19267.1 - 5.4 7.3 8.3 2 8.7 0.4 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3035) zf-CCHC_2 PF13696.6 EEA19267.1 - 9.6 6.1 7.4 0.29 11.0 1.2 1.7 2 0 0 2 2 2 0 Zinc knuckle RVT_2 PF07727.14 EEA19268.1 - 2.3e-38 132.2 0.1 2.2e-19 70.0 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EEA19268.1 - 0.013 15.0 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) YL1 PF05764.13 EEA19268.1 - 0.018 15.2 2.0 0.028 14.5 2.0 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Crr6 PF08847.11 EEA19268.1 - 0.033 13.8 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 Chlororespiratory reduction 6 OrsD PF12013.8 EEA19269.1 - 2.9e-12 47.0 9.6 2.9e-12 47.0 9.6 2.4 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA19269.1 - 3.4e-11 43.2 0.0 1.1e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA19269.1 - 0.00054 20.0 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_S8 PF00082.22 EEA19269.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Subtilase family zf-C2H2_12 PF18658.1 EEA19269.1 - 1.8 8.2 8.7 0.14 11.8 3.0 2.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type Helicase_C PF00271.31 EEA19270.1 - 3.2e-14 53.2 0.1 4.6e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EEA19270.1 - 0.004 16.4 0.0 0.0054 16.0 0.0 1.1 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 EEA19271.1 - 2.4e-11 43.7 0.1 6.6e-11 42.3 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA19271.1 - 3e-05 24.1 0.0 7.7e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit OrsD PF12013.8 EEA19273.1 - 6.2e-22 78.2 1.7 7.7e-22 77.9 0.1 2.0 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DUF3974 PF13120.6 EEA19274.1 - 0.021 14.9 0.1 0.092 12.9 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3974) RVT_2 PF07727.14 EEA19275.1 - 1.1e-11 44.9 0.0 2.7e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA19275.1 - 6.7e-07 29.5 0.1 3e-06 27.4 0.1 2.1 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EEA19275.1 - 6.3e-05 22.8 0.9 6.3e-05 22.8 0.9 1.8 2 0 0 2 2 2 1 GAG-pre-integrase domain OrsD PF12013.8 EEA19276.1 - 2.7e-28 98.7 1.3 7.1e-28 97.3 1.3 1.8 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EEA19276.1 - 0.016 14.9 0.9 0.16 11.8 0.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF4729 PF15866.5 EEA19276.1 - 0.032 13.6 0.9 0.08 12.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4729) Myb_DNA-binding PF00249.31 EEA19277.1 - 0.00059 20.0 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA19277.1 - 0.0064 16.7 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain APH PF01636.23 EEA19278.1 - 1.2e-11 45.0 0.0 3.7e-11 43.4 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Uds1 PF15456.6 EEA19283.1 - 0.016 15.4 0.2 0.03 14.5 0.1 1.5 1 1 0 1 1 1 0 Up-regulated During Septation Cob_adeno_trans PF01923.18 EEA19283.1 - 0.055 13.6 0.1 0.062 13.4 0.1 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Laminin_II PF06009.12 EEA19283.1 - 0.057 13.4 0.2 0.07 13.1 0.2 1.1 1 0 0 1 1 1 0 Laminin Domain II Med11 PF10280.9 EEA19284.1 - 0.063 13.7 0.0 0.079 13.4 0.0 1.2 1 0 0 1 1 1 0 Mediator complex protein DUF4600 PF15372.6 EEA19284.1 - 0.1 13.1 0.3 0.14 12.6 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) MCRA PF06100.11 EEA19288.1 - 4.4e-148 494.2 0.0 7.6e-111 371.3 0.0 2.0 1 1 1 2 2 2 2 MCRA family DAO PF01266.24 EEA19288.1 - 0.0013 18.4 0.0 0.0033 17.1 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Peptidase_C48 PF02902.19 EEA19289.1 - 0.00053 19.9 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF3435 PF11917.8 EEA19290.1 - 6.6e-124 414.0 0.1 4.1e-123 411.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) EarP PF10093.9 EEA19290.1 - 0.028 13.5 0.0 0.068 12.3 0.0 1.6 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP DZR PF12773.7 EEA19290.1 - 0.24 11.5 4.4 0.59 10.2 4.4 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-C2H2_11 PF16622.5 EEA19290.1 - 1.3 8.9 5.5 0.27 11.0 1.4 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EEA19290.1 - 1.3 10.0 10.7 0.21 12.5 1.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger HsbA PF12296.8 EEA19291.1 - 1.6e-15 57.6 0.1 1.3e-14 54.7 0.0 2.0 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Phosphoesterase PF04185.14 EEA19292.1 - 8.2e-11 41.7 3.6 1.2e-10 41.2 3.6 1.3 1 0 0 1 1 1 1 Phosphoesterase family Bys1 PF04681.12 EEA19293.1 - 1e-09 38.5 0.0 1.5e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein AdoMetDC_leader PF08132.11 EEA19293.1 - 0.038 13.9 0.1 0.13 12.3 0.1 1.8 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide Carb_anhydrase PF00194.21 EEA19294.1 - 4e-31 108.5 0.2 6.3e-31 107.8 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase MFS_1 PF07690.16 EEA19295.1 - 7.3e-26 90.9 25.6 7.3e-26 90.9 25.6 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily ABC_tran PF00005.27 EEA19296.1 - 5.9e-19 68.9 0.1 1.5e-18 67.7 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SbcCD_C PF13558.6 EEA19296.1 - 0.011 15.9 0.0 0.096 12.9 0.0 2.3 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EEA19296.1 - 0.033 14.1 0.3 0.072 13.0 0.3 1.5 1 0 0 1 1 1 0 RsgA GTPase DUF3046 PF11248.8 EEA19296.1 - 0.048 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3046) DIOX_N PF14226.6 EEA19297.1 - 3.8e-12 47.0 0.0 4.1e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal CvfB_WH PF17783.1 EEA19297.1 - 0.04 13.7 0.0 0.071 12.9 0.0 1.5 1 0 0 1 1 1 0 CvfB-like winged helix domain DUF768 PF05589.11 EEA19297.1 - 0.2 11.7 0.6 0.51 10.4 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF768) DDE_3 PF13358.6 EEA19298.1 - 5.3e-08 32.7 0.0 1.3e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 EEA19298.1 - 4.2e-06 26.4 0.2 1.6e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 EEA19298.1 - 8.6e-05 23.1 5.4 0.0003 21.3 0.0 3.5 3 1 1 4 4 4 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EEA19298.1 - 0.01 15.5 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_28 PF13518.6 EEA19298.1 - 0.018 15.2 0.4 0.059 13.5 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 EEA19298.1 - 0.045 13.6 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB AMP-binding PF00501.28 EEA19299.1 - 0 1723.4 1.5 1.2e-80 271.2 0.0 7.2 7 0 0 7 7 7 7 AMP-binding enzyme Condensation PF00668.20 EEA19299.1 - 0 1481.7 26.7 1.9e-56 191.7 0.0 14.0 13 1 0 13 13 13 13 Condensation domain PP-binding PF00550.25 EEA19299.1 - 8e-87 285.6 6.8 1.1e-10 41.8 0.0 9.1 8 0 0 8 8 8 8 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA19299.1 - 1.5e-12 48.3 0.0 0.49 11.4 0.0 7.9 7 0 0 7 7 7 2 AMP-binding enzyme C-terminal domain Ribonuclease PF00545.20 EEA19300.1 - 2.7e-08 34.5 0.1 3.6e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 ribonuclease Metallophos PF00149.28 EEA19301.1 - 8.9e-09 36.1 0.2 1.1e-08 35.8 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA19301.1 - 0.025 14.8 0.0 0.048 13.8 0.0 1.5 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Elicitin PF00964.17 EEA19301.1 - 0.4 10.8 3.5 4.5 7.4 0.2 2.5 2 0 0 2 2 2 0 Elicitin DUF1772 PF08592.11 EEA19302.1 - 0.00018 21.8 3.9 0.00034 20.9 3.8 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) Hemopexin PF00045.19 EEA19302.1 - 0.042 13.8 0.1 0.23 11.4 0.1 2.1 2 0 0 2 2 2 0 Hemopexin Gly_transf_sug PF04488.15 EEA19303.1 - 7.2e-10 39.4 0.0 1.7e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Tweety PF04906.13 EEA19303.1 - 0.031 12.9 0.1 6 5.4 0.0 2.1 2 0 0 2 2 2 0 Tweety PIG-L PF02585.17 EEA19304.1 - 5.4e-23 82.1 0.0 7.2e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DAO PF01266.24 EEA19305.1 - 0.0025 17.5 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase AATase PF07247.12 EEA19306.1 - 1.4e-20 73.3 0.0 2.1e-19 69.5 0.0 2.2 1 1 0 1 1 1 1 Alcohol acetyltransferase WES_acyltransf PF03007.16 EEA19306.1 - 0.0039 17.0 0.0 0.0059 16.4 0.0 1.3 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain p450 PF00067.22 EEA19307.1 - 8.1e-36 123.7 0.1 1.2e-35 123.2 0.1 1.2 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 EEA19308.1 - 3.3e-70 236.6 0.0 6.2e-70 235.7 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA19308.1 - 6.1e-62 208.7 0.1 2e-61 207.0 0.1 2.0 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EEA19308.1 - 1.1e-51 175.8 0.0 1.9e-51 175.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EEA19308.1 - 5e-49 167.5 0.0 8.5e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA19308.1 - 1.8e-38 131.2 0.0 4.7e-38 129.8 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EEA19308.1 - 2.1e-19 70.1 0.0 8.2e-19 68.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EEA19308.1 - 3.7e-19 70.1 0.0 2.3e-17 64.3 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EEA19308.1 - 1.1e-18 67.5 0.1 7.4e-18 64.8 0.1 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EEA19308.1 - 1.2e-15 57.5 0.2 3.3e-15 56.1 0.2 1.7 1 0 0 1 1 1 1 short chain dehydrogenase KAsynt_C_assoc PF16197.5 EEA19308.1 - 5.7e-13 49.3 0.0 1.7e-12 47.8 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EEA19308.1 - 3.7e-11 43.6 0.0 2.5e-10 40.9 0.0 2.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EEA19308.1 - 1.2e-09 38.0 0.0 3.5e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_11 PF08241.12 EEA19308.1 - 5.5e-09 36.6 0.0 7.3e-08 33.0 0.0 3.0 3 0 0 3 3 2 1 Methyltransferase domain PP-binding PF00550.25 EEA19308.1 - 1.2e-08 35.2 0.0 3.1e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_23 PF13489.6 EEA19308.1 - 4.5e-08 33.1 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA19308.1 - 5.7e-08 32.4 0.0 3.3e-06 26.6 0.0 3.1 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EEA19308.1 - 7.8e-06 25.8 0.0 2.5e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EEA19308.1 - 0.00025 20.9 0.0 0.0015 18.3 0.0 2.1 2 0 0 2 2 2 1 Lysine methyltransferase 3Beta_HSD PF01073.19 EEA19308.1 - 0.0013 17.8 0.0 0.0029 16.7 0.0 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 EEA19308.1 - 0.048 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain AlaDh_PNT_C PF01262.21 EEA19308.1 - 0.081 12.2 0.2 0.39 10.0 0.1 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DREV PF05219.12 EEA19308.1 - 0.098 11.7 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase AMP-binding PF00501.28 EEA19309.1 - 3.3e-64 217.0 0.0 4.4e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA19309.1 - 2.7e-17 63.5 0.3 6.1e-17 62.4 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Thioesterase PF00975.20 EEA19310.1 - 7.3e-18 65.5 0.0 9.4e-18 65.2 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EEA19310.1 - 0.00037 21.2 0.0 0.0005 20.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19310.1 - 0.00064 19.0 0.1 0.41 9.9 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EEA19310.1 - 0.0057 16.5 0.0 0.0075 16.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EEA19310.1 - 0.013 15.3 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Cellulase PF00150.18 EEA19310.1 - 0.047 13.1 0.0 0.07 12.6 0.0 1.2 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) HpaB PF03241.13 EEA19310.1 - 0.048 12.7 0.0 0.088 11.9 0.0 1.4 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal CBP4 PF07960.11 EEA19310.1 - 0.15 11.9 0.1 0.32 10.9 0.0 1.5 2 0 0 2 2 2 0 CBP4 Abhydrolase_1 PF00561.20 EEA19310.1 - 0.17 11.5 0.0 0.35 10.5 0.1 1.7 2 1 0 2 2 2 0 alpha/beta hydrolase fold DUF2974 PF11187.8 EEA19310.1 - 0.18 11.3 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) AMP-binding PF00501.28 EEA19311.1 - 2.8e-219 727.9 0.0 2.8e-75 253.5 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EEA19311.1 - 1e-154 515.6 0.0 6.7e-41 140.4 0.0 4.4 4 0 0 4 4 4 4 Condensation domain PP-binding PF00550.25 EEA19311.1 - 1.6e-52 175.8 11.0 3.6e-11 43.3 0.0 5.9 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA19311.1 - 1.3e-06 29.3 0.0 1.3 10.1 0.0 4.0 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain AATase PF07247.12 EEA19311.1 - 0.085 11.4 0.4 5.1 5.5 0.0 3.3 4 0 0 4 4 4 0 Alcohol acetyltransferase Tim17 PF02466.19 EEA19313.1 - 9.5e-31 106.5 7.5 1.2e-30 106.2 7.5 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HATPase_c_4 PF13749.6 EEA19313.1 - 0.076 13.2 0.0 0.13 12.5 0.0 1.5 1 1 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal ABC_tran PF00005.27 EEA19314.1 - 2.4e-42 144.7 0.0 6.3e-25 88.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA19314.1 - 6.8e-28 98.1 9.1 6.8e-28 98.1 9.1 3.1 3 2 0 3 3 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA19314.1 - 3.1e-14 53.0 0.8 2e-05 24.1 0.0 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA19314.1 - 3.2e-09 37.0 0.2 0.093 12.5 0.0 5.0 4 1 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA19314.1 - 5.7e-09 35.6 1.3 0.00079 19.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA19314.1 - 2.1e-06 28.4 0.3 0.048 14.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EEA19314.1 - 6.1e-06 26.7 0.1 0.093 13.1 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EEA19314.1 - 2.9e-05 24.1 0.6 0.43 10.7 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EEA19314.1 - 0.00055 20.2 0.1 1.1 9.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EEA19314.1 - 0.00076 19.6 0.2 1.5 8.8 0.1 2.6 2 0 0 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 EEA19314.1 - 0.0013 18.6 0.3 0.93 9.4 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase FtsK_SpoIIIE PF01580.18 EEA19314.1 - 0.0016 17.8 0.3 0.99 8.7 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family T2SSE PF00437.20 EEA19314.1 - 0.0017 17.5 0.7 0.57 9.2 0.1 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_15 PF13175.6 EEA19314.1 - 0.0019 18.0 1.8 0.27 10.9 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 EEA19314.1 - 0.0026 18.3 0.0 0.32 11.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EEA19314.1 - 0.0075 16.1 0.7 0.49 10.1 0.1 3.0 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein DUF87 PF01935.17 EEA19314.1 - 0.0076 16.4 0.7 0.73 9.9 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain ATP-synt_ab PF00006.25 EEA19314.1 - 0.0099 15.6 1.3 1.7 8.2 0.1 2.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.12 EEA19314.1 - 0.014 14.7 0.1 0.43 9.8 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 EEA19314.1 - 0.018 15.4 0.3 8.9 6.8 0.1 3.4 3 0 0 3 3 3 0 RNA helicase AAA_30 PF13604.6 EEA19314.1 - 0.025 14.3 0.2 4.1 7.1 0.0 2.7 3 0 0 3 3 2 0 AAA domain ABC_ATPase PF09818.9 EEA19314.1 - 0.056 12.2 0.7 0.25 10.1 0.1 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class MeaB PF03308.16 EEA19314.1 - 0.071 12.1 0.2 0.24 10.3 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 EEA19314.1 - 0.22 11.0 0.7 12 5.4 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Cupin_2 PF07883.11 EEA19315.1 - 1.4e-08 34.3 0.0 2.2e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain MFS_1 PF07690.16 EEA19316.1 - 5.7e-41 140.6 38.2 5.7e-41 140.6 38.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19316.1 - 3.3e-13 49.3 8.5 3.3e-13 49.3 8.5 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 EEA19316.1 - 0.03 12.6 9.8 0.21 9.9 3.8 2.6 1 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TMPIT PF07851.13 EEA19316.1 - 0.99 8.6 7.1 0.064 12.5 1.8 1.7 2 0 0 2 2 2 0 TMPIT-like protein MFS_1 PF07690.16 EEA19317.1 - 4.2e-24 85.1 50.8 1.3e-23 83.6 48.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EEA19318.1 - 1.6e-17 63.5 41.4 6e-17 61.6 39.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EEA19319.1 - 1.6e-17 63.5 41.4 6e-17 61.6 39.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19320.1 - 3.1e-111 372.5 19.2 3.5e-111 372.3 19.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19320.1 - 8.5e-23 80.8 32.3 9.2e-18 64.3 3.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19321.1 - 1.5e-121 406.5 31.8 1.7e-121 406.3 31.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19321.1 - 1.6e-27 96.4 69.8 2.9e-24 85.6 38.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short_C2 PF13561.6 EEA19322.1 - 1.7e-62 211.0 0.0 2e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA19322.1 - 2.8e-46 157.4 0.0 3.4e-46 157.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA19322.1 - 9.3e-12 45.2 0.1 1.5e-11 44.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA19322.1 - 2.6e-06 27.1 0.0 0.0001 21.8 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA19322.1 - 1.7e-05 24.1 0.0 2.4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EEA19322.1 - 5.6e-05 22.7 0.0 8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 EEA19322.1 - 0.0023 17.9 0.0 0.0036 17.2 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EEA19322.1 - 0.0069 16.8 0.0 0.012 16.0 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_2 PF03446.15 EEA19322.1 - 0.023 14.9 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_31 PF13847.6 EEA19322.1 - 0.023 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TrkA_N PF02254.18 EEA19322.1 - 0.12 12.6 0.0 0.51 10.6 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain Ldh_1_N PF00056.23 EEA19322.1 - 0.14 12.2 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EEA19322.1 - 0.16 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AP_endonuc_2 PF01261.24 EEA19323.1 - 1.3e-28 99.9 0.0 2.2e-28 99.1 0.0 1.4 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel DIOX_N PF14226.6 EEA19324.1 - 9.3e-17 61.9 0.0 1.2e-15 58.2 0.0 2.2 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA19324.1 - 2.6e-16 60.0 0.0 4.4e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 EEA19325.1 - 7.5e-07 29.2 11.0 1.6e-06 28.1 11.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA19325.1 - 0.0029 16.7 1.3 0.0064 15.5 1.3 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cep3 PF16846.5 EEA19325.1 - 0.0077 14.8 0.5 0.015 13.8 0.0 1.6 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit B Xan_ur_permease PF00860.20 EEA19326.1 - 1.4e-51 175.5 31.3 6.5e-51 173.2 31.3 1.8 1 1 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 EEA19326.1 - 0.00028 21.3 5.6 0.00028 21.3 5.6 3.8 4 0 0 4 4 4 1 Molybdate transporter of MFS superfamily Amidohydro_1 PF01979.20 EEA19327.1 - 1.2e-53 182.6 0.2 1.7e-53 182.1 0.2 1.2 1 0 0 1 1 1 1 Amidohydrolase family Fungal_trans PF04082.18 EEA19327.1 - 5.9e-20 71.4 0.0 9e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_3 PF07969.11 EEA19327.1 - 7.9e-20 71.8 0.8 5.1e-15 55.9 0.1 2.7 2 1 1 3 3 3 2 Amidohydrolase family Zn_clus PF00172.18 EEA19327.1 - 3.9e-05 23.7 6.1 7.8e-05 22.7 6.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain A_deaminase PF00962.22 EEA19327.1 - 0.014 14.8 0.2 0.085 12.2 0.0 2.0 2 0 0 2 2 2 0 Adenosine/AMP deaminase MFS_1 PF07690.16 EEA19328.1 - 4.6e-32 111.3 40.3 5.6e-32 111.0 40.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA19328.1 - 3.7e-07 29.8 23.2 7.6e-07 28.7 9.2 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF4064 PF13273.6 EEA19328.1 - 0.026 14.8 0.9 0.026 14.8 0.9 3.9 3 2 0 3 3 3 0 Protein of unknown function (DUF4064) COesterase PF00135.28 EEA19329.1 - 4.4e-101 339.3 0.0 4.9e-101 339.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA19329.1 - 5.4e-07 29.7 0.4 4.1e-06 26.8 0.4 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold PALP PF00291.25 EEA19330.1 - 1.5e-42 146.0 0.1 1.7e-42 145.8 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme LYTB PF02401.18 EEA19330.1 - 0.057 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 LytB protein tRNA-synt_1d PF00750.19 EEA19333.1 - 4.3e-63 213.4 0.1 6.1e-63 212.9 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EEA19333.1 - 1.9e-17 63.5 0.1 4.1e-17 62.4 0.1 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain Abhydrolase_3 PF07859.13 EEA19334.1 - 9.8e-45 153.0 0.0 1.3e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA19334.1 - 6.2e-05 22.1 0.1 0.00043 19.3 0.1 1.9 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EEA19334.1 - 0.021 14.3 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Glyco_hydro_18 PF00704.28 EEA19335.1 - 1.6e-22 80.7 1.4 4e-22 79.3 1.4 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_1 PF00734.18 EEA19335.1 - 5.3e-09 35.9 12.5 5.3e-09 35.9 12.5 3.1 2 0 0 2 2 2 1 Fungal cellulose binding domain MFS_1 PF07690.16 EEA19336.1 - 2.5e-32 112.2 35.5 1.3e-31 109.8 34.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4044 PF13253.6 EEA19337.1 - 3.2 7.4 5.8 0.76 9.3 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) Cytochrom_B_C PF00032.17 EEA19337.1 - 7.4 6.9 6.7 17 5.7 0.2 2.7 3 0 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD DUF4044 PF13253.6 EEA19338.1 - 3.1 7.4 5.8 0.75 9.4 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) Cytochrom_B_C PF00032.17 EEA19338.1 - 8.1 6.8 6.8 17 5.8 0.2 2.8 3 1 1 4 4 4 0 Cytochrome b(C-terminal)/b6/petD DUF4044 PF13253.6 EEA19339.1 - 0.12 11.9 1.6 0.51 9.9 1.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) Cytochrom_B_C PF00032.17 EEA19339.1 - 1.4 9.2 5.4 10 6.5 0.2 2.7 3 0 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD FAD_binding_3 PF01494.19 EEA19340.1 - 1.3e-16 60.9 0.0 1.7e-15 57.1 0.0 2.3 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA19340.1 - 3.6e-06 27.1 0.1 8.7e-06 25.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA19340.1 - 0.00042 20.0 0.1 0.00091 18.9 0.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA19340.1 - 0.0063 15.8 0.0 0.017 14.4 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA19340.1 - 0.0086 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EEA19340.1 - 0.014 16.0 0.0 0.1 13.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EEA19340.1 - 0.036 14.3 0.0 0.092 13.0 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 EEA19340.1 - 0.18 11.7 0.0 2 8.3 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.16 EEA19342.1 - 8.3e-19 67.7 32.4 1.2e-18 67.2 32.4 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.6 EEA19342.1 - 0.037 13.7 5.5 5.5 6.6 0.8 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) HbrB PF08539.11 EEA19342.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 HbrB-like SCIMP PF15050.6 EEA19343.1 - 0.048 14.1 1.0 0.11 13.0 1.0 1.6 1 0 0 1 1 1 0 SCIMP protein DUF5337 PF17272.2 EEA19343.1 - 0.66 9.8 5.0 2 8.3 0.3 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5337) SCIMP PF15050.6 EEA19344.1 - 0.044 14.3 1.0 0.12 12.9 1.0 1.8 1 0 0 1 1 1 0 SCIMP protein DUF5337 PF17272.2 EEA19344.1 - 0.53 10.2 4.6 2.2 8.2 0.3 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5337) adh_short PF00106.25 EEA19345.1 - 0.0049 16.3 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase DUF1658 PF07871.11 EEA19345.1 - 1.2 9.2 4.2 1.7 8.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1658) Zn_clus PF00172.18 EEA19346.1 - 6.5e-06 26.2 10.7 1.3e-05 25.2 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA19348.1 - 1.9e-10 40.1 2.6 3.9e-10 39.1 0.5 2.0 1 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19348.1 - 0.00059 19.9 2.3 0.0015 18.6 2.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain efb-c PF12199.8 EEA19348.1 - 0.017 15.1 1.1 0.097 12.7 0.1 2.4 2 0 0 2 2 2 0 Extracellular fibrinogen binding protein C terminal Zn_clus PF00172.18 EEA19349.1 - 4.3e-05 23.5 13.6 7.5e-05 22.8 13.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA19349.1 - 0.016 14.1 0.1 0.039 12.8 0.0 1.7 2 0 0 2 2 2 0 Fungal specific transcription factor domain Vps51 PF08700.11 EEA19349.1 - 0.24 11.5 0.7 0.49 10.5 0.0 1.8 2 0 0 2 2 2 0 Vps51/Vps67 PBP PF01161.20 EEA19351.1 - 1.1e-10 41.9 0.6 1.4e-10 41.5 0.6 1.3 1 1 0 1 1 1 1 Phosphatidylethanolamine-binding protein LUD_dom PF02589.15 EEA19352.1 - 0.91 9.2 6.0 0.67 9.6 2.4 2.3 1 1 0 2 2 2 0 LUD domain Zn_clus PF00172.18 EEA19353.1 - 0.037 14.2 1.0 0.071 13.2 1.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribul_P_3_epim PF00834.19 EEA19354.1 - 3.4e-61 206.1 0.0 4.5e-60 202.4 0.0 2.0 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.24 EEA19354.1 - 0.043 13.4 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family ThiG PF05690.14 EEA19354.1 - 0.052 12.8 0.1 0.072 12.4 0.1 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG SH3BGR PF04908.15 EEA19355.1 - 9.2e-05 22.5 1.3 0.00026 21.1 0.0 2.5 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein CYSTM PF12734.7 EEA19356.1 - 5.1e-09 36.3 24.4 5.1e-09 36.3 24.4 5.3 2 2 2 4 4 4 1 Cysteine-rich TM module stress tolerance zf-BED PF02892.15 EEA19357.1 - 0.019 15.0 3.5 0.73 9.9 0.1 2.6 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_4 PF13894.6 EEA19357.1 - 9.7 7.3 6.6 5.4 8.1 2.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA19358.1 - 4e-06 27.0 20.1 0.16 12.5 2.5 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA19358.1 - 1.2e-05 25.7 22.1 0.00078 20.1 2.4 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger Homeodomain PF00046.29 EEA19358.1 - 0.00065 19.5 0.6 0.0024 17.7 0.6 2.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EEA19358.1 - 0.0019 18.1 1.3 0.0034 17.3 0.6 1.9 2 0 0 2 2 2 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.16 EEA19358.1 - 0.0041 17.1 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Homez PF11569.8 EEA19358.1 - 0.038 13.5 0.4 0.19 11.2 0.4 2.1 1 1 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HA PF03457.14 EEA19358.1 - 0.06 13.7 0.4 0.27 11.6 0.1 2.2 2 0 0 2 2 2 0 Helicase associated domain zf-met PF12874.7 EEA19358.1 - 2.7 8.5 5.6 3.4 8.2 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EEA19358.1 - 3.9 7.9 9.2 26 5.2 0.0 4.2 3 1 0 4 4 4 0 C2H2 type zinc-finger (2 copies) TPT PF03151.16 EEA19359.1 - 1.2e-19 70.8 16.8 1.5e-19 70.4 16.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA19359.1 - 2.8e-05 24.3 32.3 0.0049 17.1 12.4 2.6 2 2 0 2 2 2 2 EamA-like transporter family RNase_H PF00075.24 EEA19360.1 - 1.3e-09 38.3 0.0 1.8e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 RNase H MFS_1 PF07690.16 EEA19362.1 - 7.5e-22 77.7 44.3 7.5e-22 77.7 44.3 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA19362.1 - 5.9e-16 58.0 23.9 8.1e-16 57.6 23.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ArAE_2_N PF10337.9 EEA19362.1 - 0.078 12.0 6.1 0.017 14.2 2.2 1.8 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal Ank_2 PF12796.7 EEA19364.1 - 1.5e-48 163.3 0.0 4.7e-13 49.5 0.0 2.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19364.1 - 2.6e-28 98.0 0.0 9.7e-08 32.4 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA19364.1 - 5.2e-19 67.8 0.3 2e-05 24.8 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EEA19364.1 - 4.2e-18 63.6 0.0 0.0002 21.5 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EEA19364.1 - 1.1e-15 57.5 0.0 2.1e-05 24.7 0.4 4.7 2 1 4 6 6 6 4 Ankyrin repeats (many copies) PilZ_2 PF16823.5 EEA19364.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.7 2 0 0 2 2 2 0 Atypical PilZ domain, cyclic di-GMP receptor DUF3029 PF11230.8 EEA19364.1 - 0.14 10.5 0.0 0.19 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) PGM_PMM_I PF02878.16 EEA19365.1 - 3.1e-14 52.8 0.0 7.7e-14 51.6 0.0 1.7 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EEA19365.1 - 5.7e-07 29.7 0.0 9.7e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EEA19365.1 - 2.2e-06 28.2 0.0 4.5e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EEA19365.1 - 2.9e-05 24.1 0.0 9.4e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ADH_zinc_N PF00107.26 EEA19366.1 - 4.8e-09 36.3 0.0 8.8e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA19366.1 - 0.00028 20.7 0.0 0.0011 18.8 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_11 PF08241.12 EEA19367.1 - 9.9e-07 29.3 0.0 2.2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19367.1 - 0.016 15.9 0.0 0.043 14.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain LSM PF01423.22 EEA19368.1 - 2.6e-18 65.4 0.8 3.4e-18 65.1 0.8 1.2 1 0 0 1 1 1 1 LSM domain LRR_9 PF14580.6 EEA19368.1 - 0.0051 16.3 0.1 0.0058 16.1 0.1 1.1 1 0 0 1 1 1 1 Leucine-rich repeat Hfq PF17209.3 EEA19368.1 - 0.041 13.5 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 Hfq protein SM-ATX PF14438.6 EEA19368.1 - 0.15 12.3 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Glyco_hydro_114 PF03537.13 EEA19369.1 - 2.4e-89 298.6 2.5 3e-89 298.3 2.5 1.1 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 ETRAMP PF09716.10 EEA19369.1 - 0.024 14.7 1.0 0.4 10.8 0.5 2.4 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) RuBisCO_large_N PF02788.16 EEA19369.1 - 0.12 12.6 0.2 0.27 11.4 0.2 1.6 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain DRMBL PF07522.14 EEA19370.1 - 1.8e-34 118.3 0.0 3.8e-34 117.2 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EEA19370.1 - 2.8e-06 27.0 0.0 5.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EEA19370.1 - 0.023 14.7 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily p450 PF00067.22 EEA19371.1 - 1.3e-96 324.2 0.0 1.5e-96 324.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SMP PF04927.12 EEA19372.1 - 2e-15 57.0 14.1 1.4e-05 25.4 1.6 3.1 2 1 1 3 3 3 3 Seed maturation protein Ifi-6-16 PF06140.13 EEA19372.1 - 0.0025 17.7 0.4 0.0025 17.7 0.4 2.4 3 0 0 3 3 3 1 Interferon-induced 6-16 family DUF3435 PF11917.8 EEA19374.1 - 5.7e-14 51.9 0.0 7.8e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) DUF3435 PF11917.8 EEA19375.1 - 2.1e-22 79.7 0.0 2.2e-22 79.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) DUF3435 PF11917.8 EEA19376.1 - 1.9e-07 30.4 0.0 2.7e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) APH PF01636.23 EEA19377.1 - 1.6e-16 61.0 0.0 3.4e-16 59.9 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EEA19377.1 - 0.04 13.1 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase Phycobilisome PF00502.19 EEA19378.1 - 0.077 12.9 0.8 0.12 12.3 0.8 1.2 1 0 0 1 1 1 0 Phycobilisome protein Atthog PF18800.1 EEA19379.1 - 0.0016 18.4 1.2 0.0016 18.4 1.2 2.4 2 1 0 2 2 2 1 Attenuator of Hedgehog DUF2678 PF10856.8 EEA19379.1 - 2 8.4 10.0 0.067 13.1 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) WD40 PF00400.32 EEA19380.1 - 5.9e-25 87.0 0.3 8.5e-11 42.2 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19380.1 - 2.1e-08 34.4 0.0 4.8e-06 26.8 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA19380.1 - 0.00016 21.1 0.0 0.00027 20.3 0.0 1.3 1 0 0 1 1 1 1 WD40-like domain PALB2_WD40 PF16756.5 EEA19380.1 - 0.036 13.0 0.2 0.87 8.4 0.0 2.0 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 EEA19380.1 - 0.08 11.9 0.0 0.98 8.3 0.0 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 EEA19380.1 - 0.13 11.9 0.1 0.24 10.9 0.1 1.4 1 1 0 1 1 1 0 PQQ-like domain Cytochrom_D1 PF02239.16 EEA19380.1 - 0.21 10.1 0.0 0.35 9.4 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain DIOX_N PF14226.6 EEA19382.1 - 6.3e-20 72.1 0.0 9.1e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA19382.1 - 1.9e-17 63.6 0.0 6.7e-17 61.8 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Lactamase_B_2 PF12706.7 EEA19383.1 - 1.2e-30 106.6 0.0 1e-29 103.5 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EEA19383.1 - 9.4e-12 45.1 0.0 6.8e-11 42.3 0.0 2.2 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EEA19383.1 - 0.03 14.3 0.3 1.8 8.5 0.0 2.8 3 1 1 4 4 4 0 Metallo-beta-lactamase superfamily Zn_clus PF00172.18 EEA19384.1 - 6.6e-10 39.0 9.4 1.4e-09 37.9 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OPT PF03169.15 EEA19385.1 - 1.5e-184 615.1 52.7 1.8e-184 614.9 52.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Pkinase PF00069.25 EEA19386.1 - 1.7e-25 89.9 0.0 1.5e-24 86.8 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19386.1 - 6.9e-10 38.6 0.1 5.5e-05 22.6 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase ApbA PF02558.16 EEA19388.1 - 7.3e-33 113.4 0.0 9.5e-33 113.0 0.0 1.1 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EEA19388.1 - 4.3e-27 94.8 0.0 6.7e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal FMN_dh PF01070.18 EEA19389.1 - 9.5e-111 370.2 0.6 1.2e-110 369.9 0.6 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EEA19389.1 - 2.4e-22 78.9 0.0 1.5e-21 76.3 0.0 2.2 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EEA19389.1 - 1.9e-06 27.3 0.1 3.3e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EEA19389.1 - 1.5e-05 24.2 1.3 6e-05 22.2 0.5 2.0 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EEA19389.1 - 0.00081 18.9 1.0 0.0012 18.3 1.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 EEA19389.1 - 0.063 12.6 0.1 1.2 8.4 0.0 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Beta_helix PF13229.6 EEA19390.1 - 9.3e-12 45.1 16.4 9.3e-12 45.1 16.4 3.8 2 1 1 3 3 3 3 Right handed beta helix region Abhydrolase_6 PF12697.7 EEA19391.1 - 1e-14 55.7 0.0 1.5e-14 55.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19391.1 - 7.5e-06 25.4 0.0 1.5e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA19391.1 - 2.7e-05 23.9 0.0 9.8e-05 22.1 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.14 EEA19391.1 - 0.017 13.9 0.0 0.023 13.4 0.0 1.2 1 0 0 1 1 1 0 Ndr family Glyco_hydro_18 PF00704.28 EEA19392.1 - 6.4e-52 177.2 0.0 1e-51 176.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EEA19392.1 - 6.6e-13 48.9 32.5 2.4e-10 40.7 11.5 2.5 2 0 0 2 2 2 2 Chitin recognition protein Ciart PF15673.5 EEA19392.1 - 0.35 10.2 3.3 0.6 9.5 3.3 1.3 1 0 0 1 1 1 0 Circadian-associated transcriptional repressor LysM PF01476.20 EEA19393.1 - 9.9e-25 86.3 0.5 1.1e-08 35.0 0.1 3.4 3 0 0 3 3 3 3 LysM domain Methyltransf_2 PF00891.18 EEA19395.1 - 1.3e-15 57.3 0.0 3.4e-15 55.9 0.0 1.6 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EEA19395.1 - 0.011 15.6 0.0 0.033 14.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19395.1 - 0.02 15.6 0.1 0.11 13.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Ad_Cy_reg PF16701.5 EEA19395.1 - 0.044 13.5 0.0 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 Adenylate cyclase regulatory domain FAD_binding_3 PF01494.19 EEA19396.1 - 2.2e-25 89.6 0.0 1.3e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA19396.1 - 1.5e-06 28.3 0.6 4.8e-06 26.7 0.6 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA19396.1 - 2e-06 27.7 2.4 0.00013 21.6 1.3 2.1 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA19396.1 - 2.4e-06 26.9 2.2 3.7e-06 26.3 2.2 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA19396.1 - 9.2e-06 25.1 1.3 0.002 17.4 0.7 2.1 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA19396.1 - 0.0001 21.1 1.1 0.00024 19.9 1.1 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EEA19396.1 - 0.00067 19.1 0.3 0.001 18.5 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EEA19396.1 - 0.00074 18.7 0.3 0.0018 17.4 0.3 1.5 1 1 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EEA19396.1 - 0.0026 17.1 0.2 0.0053 16.1 0.2 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EEA19396.1 - 0.0033 16.6 1.2 0.0047 16.1 1.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EEA19396.1 - 0.0034 16.6 0.5 0.0058 15.9 0.5 1.3 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 EEA19396.1 - 0.0038 16.2 0.4 0.11 11.3 0.3 2.2 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EEA19396.1 - 0.0071 16.3 0.2 0.28 11.2 0.2 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EEA19396.1 - 0.01 15.1 0.5 0.017 14.4 0.5 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EEA19396.1 - 0.018 14.1 0.0 0.17 10.9 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase Amino_oxidase PF01593.24 EEA19396.1 - 0.019 14.3 0.1 0.054 12.8 0.0 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EEA19396.1 - 0.076 13.6 1.3 0.17 12.5 1.3 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EEA19396.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EEA19396.1 - 0.17 11.5 0.1 0.37 10.4 0.1 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MCRA PF06100.11 EEA19396.1 - 0.34 9.7 0.5 0.49 9.1 0.5 1.1 1 0 0 1 1 1 0 MCRA family ketoacyl-synt PF00109.26 EEA19397.1 - 1e-74 251.3 0.0 1.9e-74 250.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EEA19397.1 - 9.1e-59 199.1 0.2 9.1e-59 199.1 0.2 2.1 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EEA19397.1 - 3.7e-39 135.1 0.0 8e-39 134.0 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA19397.1 - 1.4e-35 121.9 0.0 3.7e-35 120.5 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EEA19397.1 - 1.1e-25 91.1 0.0 3.4e-25 89.5 0.0 1.9 1 0 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 EEA19397.1 - 5.5e-19 68.3 8.2 1.2e-10 41.6 1.8 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 EEA19397.1 - 1.1e-07 31.4 0.0 2.1e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Abhydrolase_6 PF12697.7 EEA19397.1 - 5e-05 24.0 0.1 0.0067 17.0 0.0 2.8 3 0 0 3 3 3 1 Alpha/beta hydrolase family KAsynt_C_assoc PF16197.5 EEA19397.1 - 0.00011 22.6 0.0 0.00036 21.0 0.0 2.0 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EEA19397.1 - 0.00067 19.1 0.2 0.0014 18.0 0.2 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_1 PF00561.20 EEA19397.1 - 0.047 13.3 0.1 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold MFS_1 PF07690.16 EEA19398.1 - 6.8e-28 97.6 53.0 6.8e-28 97.6 53.0 3.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19398.1 - 2.7e-09 36.4 13.6 2.7e-09 36.4 13.6 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter ADH_zinc_N PF00107.26 EEA19399.1 - 8.7e-12 45.1 0.1 1.7e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA19399.1 - 9.8e-07 28.6 0.0 2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EEA19399.1 - 0.011 15.1 0.3 0.011 15.1 0.3 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EEA19399.1 - 0.047 14.7 0.0 0.1 13.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase adh_short PF00106.25 EEA19399.1 - 0.068 12.6 0.6 0.11 11.9 0.6 1.3 1 0 0 1 1 1 0 short chain dehydrogenase NUP PF06516.11 EEA19400.1 - 1.8e-137 457.8 0.1 2.1e-137 457.6 0.1 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) Glyco_hydro_12 PF01670.16 EEA19401.1 - 1.5e-19 70.9 8.2 2.4e-17 63.7 8.2 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 Glyco_tranf_2_3 PF13641.6 EEA19402.1 - 2.6e-24 86.4 0.0 4.9e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EEA19402.1 - 1.4e-17 64.3 0.4 1.4e-17 64.3 0.4 2.7 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EEA19402.1 - 1.7e-14 54.0 0.0 3.6e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Cellulose_synt PF03552.14 EEA19402.1 - 7e-12 44.7 9.3 6.4e-09 34.9 0.2 3.0 2 1 2 4 4 4 2 Cellulose synthase Glyco_transf_21 PF13506.6 EEA19402.1 - 4.5e-11 42.5 0.0 7.3e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 EEA19402.1 - 0.0013 17.5 0.1 0.017 13.7 0.0 2.2 2 0 0 2 2 2 1 Chitin synthase GFA PF04828.14 EEA19403.1 - 9.8e-25 86.7 0.0 1.3e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EEA19403.1 - 0.015 15.3 0.6 0.7 10.0 0.0 2.2 2 0 0 2 2 2 0 Double zinc ribbon Nudix_N_2 PF14803.6 EEA19403.1 - 0.39 10.7 0.1 0.39 10.7 0.1 2.7 3 0 0 3 3 3 0 Nudix N-terminal UPF0258 PF06789.12 EEA19404.1 - 0.18 11.9 0.1 0.35 11.0 0.1 1.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0258) DAO PF01266.24 EEA19405.1 - 2.8e-41 142.3 0.1 3.2e-41 142.1 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA19405.1 - 5.2e-05 22.6 0.6 0.015 14.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA19405.1 - 5.8e-05 23.1 0.4 0.007 16.4 0.1 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EEA19405.1 - 0.00036 20.0 0.1 0.0079 15.5 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EEA19405.1 - 0.0017 18.5 0.9 0.0048 17.1 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA19405.1 - 0.0051 16.1 0.0 0.012 14.8 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA19405.1 - 0.015 14.3 0.3 0.043 12.9 0.2 1.8 1 1 1 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 EEA19405.1 - 0.022 14.0 0.1 0.043 13.1 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 EEA19405.1 - 0.085 13.4 0.4 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase YflT PF11181.8 EEA19405.1 - 0.097 13.2 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 Heat induced stress protein YflT MCRA PF06100.11 EEA19405.1 - 0.21 10.4 0.1 0.3 9.8 0.1 1.2 1 0 0 1 1 1 0 MCRA family Beta-lactamase PF00144.24 EEA19406.1 - 2.6e-50 171.5 1.9 1.5e-49 169.1 0.9 1.9 2 0 0 2 2 2 1 Beta-lactamase DUF3471 PF11954.8 EEA19406.1 - 3.5e-12 46.7 0.0 6.7e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) DUF3433 PF11915.8 EEA19407.1 - 6.8e-31 106.6 13.2 2.2e-24 85.7 3.2 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) Aldedh PF00171.22 EEA19408.1 - 6.7e-183 608.4 0.1 7.6e-183 608.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ADH_N PF08240.12 EEA19409.1 - 2e-29 101.7 0.3 3.7e-29 100.8 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA19409.1 - 1.3e-23 83.4 0.4 2.3e-23 82.6 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA19409.1 - 0.00014 22.9 0.0 0.00024 22.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA19409.1 - 0.0089 15.4 0.1 0.024 14.0 0.2 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.25 EEA19409.1 - 0.022 14.2 1.5 0.047 13.1 1.1 1.8 1 1 1 2 2 2 0 short chain dehydrogenase Gpr1_Fun34_YaaH PF01184.19 EEA19410.1 - 3.1e-33 115.2 17.9 3.8e-33 114.8 17.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 EEA19411.1 - 3.1e-33 115.2 17.9 3.8e-33 114.8 17.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Ferritin_2 PF13668.6 EEA19413.1 - 4.6e-38 130.5 3.8 4.6e-38 130.5 3.8 1.7 2 0 0 2 2 2 1 Ferritin-like domain Zn_clus PF00172.18 EEA19415.1 - 0.00024 21.1 0.8 0.00068 19.7 0.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EEA19416.1 - 4.3e-90 302.8 16.9 7.5e-90 302.0 16.9 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19416.1 - 5.4e-25 88.1 31.3 6.9e-25 87.7 31.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Nop52 PF05997.12 EEA19416.1 - 0.055 13.3 0.2 0.1 12.4 0.2 1.3 1 0 0 1 1 1 0 Nucleolar protein,Nop52 OATP PF03137.20 EEA19416.1 - 0.93 7.7 7.8 1.1 7.4 6.6 1.9 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Sacchrp_dh_NADP PF03435.18 EEA19417.1 - 5.9e-21 75.1 0.7 1e-20 74.3 0.7 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EEA19417.1 - 0.0085 16.0 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EEA19417.1 - 0.015 15.3 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 EEA19417.1 - 0.031 14.7 0.1 0.09 13.2 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain F-box-like PF12937.7 EEA19418.1 - 4.1e-05 23.4 0.3 0.00011 22.1 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EEA19418.1 - 0.00098 19.0 0.3 0.003 17.4 0.3 1.8 1 0 0 1 1 1 1 F-box F-box PF00646.33 EEA19418.1 - 0.023 14.6 2.2 0.17 11.8 0.9 2.7 2 0 0 2 2 2 0 F-box domain NCD1 PF04904.13 EEA19418.1 - 0.099 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) G-patch PF01585.23 EEA19420.1 - 8.6e-13 48.0 1.1 1.8e-12 46.9 1.1 1.5 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 EEA19420.1 - 1.6e-09 36.9 3.4 2.8e-09 36.1 3.4 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EEA19420.1 - 1.1e-08 34.8 0.3 0.00013 21.7 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 EEA19420.1 - 8.7e-08 32.1 0.2 2.5e-07 30.7 0.2 1.8 1 0 0 1 1 1 1 G-patch domain RED_N PF07808.13 EEA19420.1 - 0.0038 16.9 1.0 0.0038 16.9 1.0 2.2 3 0 0 3 3 3 1 RED-like protein N-terminal region NCD3G PF07562.14 EEA19420.1 - 0.99 9.4 6.9 1.9 8.5 2.2 2.3 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Alpha-amylase PF00128.24 EEA19421.1 - 4e-114 381.7 0.6 7.3e-114 380.8 0.6 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EEA19421.1 - 5.4e-08 32.8 0.1 1e-07 32.0 0.1 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 EEA19421.1 - 0.0049 16.0 0.0 0.0094 15.1 0.0 1.4 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Alpha-amylase_C PF02806.18 EEA19421.1 - 0.016 15.7 0.1 0.042 14.3 0.1 1.8 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain Fringe PF02434.16 EEA19423.1 - 1.6e-05 24.4 0.1 0.00034 20.1 0.1 2.2 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 EEA19423.1 - 0.016 15.1 0.4 0.031 14.2 0.4 1.4 1 0 0 1 1 1 0 PAN domain PAN_1 PF00024.26 EEA19423.1 - 0.028 14.4 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 PAN domain CAP_N PF01213.19 EEA19423.1 - 8.6 5.7 9.3 15 5.0 9.3 1.4 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DFP PF04127.15 EEA19424.1 - 2.1e-14 53.8 0.0 5.3e-06 26.4 0.0 3.2 2 1 1 3 3 3 3 DNA / pantothenate metabolism flavoprotein Lipase_2 PF01674.18 EEA19425.1 - 4.8e-07 29.5 0.0 7.8e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 Lipase (class 2) DUF2974 PF11187.8 EEA19425.1 - 0.00011 21.9 0.2 0.00016 21.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EEA19425.1 - 0.00015 21.1 0.0 0.00018 20.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA19425.1 - 0.0017 19.0 0.1 0.0024 18.5 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA19425.1 - 0.0058 16.3 0.2 0.022 14.4 0.1 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF676 PF05057.14 EEA19425.1 - 0.012 15.1 0.2 0.029 13.9 0.2 1.6 1 1 0 1 1 1 0 Putative serine esterase (DUF676) PGAP1 PF07819.13 EEA19425.1 - 0.025 14.3 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein BAAT_C PF08840.11 EEA19425.1 - 0.046 13.6 0.0 0.063 13.2 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Palm_thioest PF02089.15 EEA19425.1 - 0.061 13.1 0.0 0.074 12.9 0.0 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase FSH1 PF03959.13 EEA19425.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Rieske PF00355.26 EEA19426.1 - 3e-10 39.9 0.0 5.3e-10 39.1 0.0 1.7 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EEA19426.1 - 2.6e-06 27.3 0.0 4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain GST_N_3 PF13417.6 EEA19427.1 - 2.4e-10 40.7 0.0 9.4e-10 38.8 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA19427.1 - 3.4e-10 40.1 0.0 6.2e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA19427.1 - 5.4e-06 26.3 0.0 2e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA19427.1 - 0.0024 18.0 0.0 0.0084 16.3 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA19427.1 - 0.0061 16.9 0.0 0.025 14.9 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA19427.1 - 0.067 13.4 0.0 0.13 12.4 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EEA19427.1 - 0.12 13.0 0.0 0.21 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TFIIA_gamma_N PF02268.16 EEA19427.1 - 0.12 12.4 0.1 2.7 8.1 0.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain DDE_Tnp_1_7 PF13843.6 EEA19428.1 - 6.9e-58 196.6 0.3 1.3e-57 195.7 0.3 1.5 1 1 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA19428.1 - 7.8e-12 45.8 9.4 1.7e-11 44.7 9.4 1.6 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon PNP_UDP_1 PF01048.20 EEA19429.1 - 0.00033 20.0 0.0 0.00057 19.2 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 EEA19429.1 - 0.042 14.2 0.0 0.17 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Atg29_N PF18388.1 EEA19430.1 - 2.7e-26 91.1 1.3 5e-26 90.3 1.3 1.5 1 0 0 1 1 1 1 Atg29 N-terminal domain Drf_GBD PF06371.13 EEA19430.1 - 0.014 15.0 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain APH PF01636.23 EEA19431.1 - 5.6e-06 26.5 0.0 7.6e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA19431.1 - 0.051 13.2 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase TMEM71 PF15121.6 EEA19431.1 - 0.075 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 TMEM71 protein family Dak1 PF02733.17 EEA19432.1 - 7.1e-26 90.8 0.5 8.4e-26 90.6 0.5 1.0 1 0 0 1 1 1 1 Dak1 domain RVT_2 PF07727.14 EEA19433.1 - 9.4e-11 41.8 0.0 1.6e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA19433.1 - 1.6e-07 31.5 0.3 5.7e-06 26.5 0.0 2.9 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 EEA19433.1 - 0.00023 21.0 0.2 0.00075 19.3 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA19433.1 - 0.14 12.4 0.0 0.75 10.0 0.0 2.3 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Integrase_H2C2 PF17921.1 EEA19433.1 - 0.85 9.8 8.7 0.47 10.6 0.1 3.6 3 0 0 3 3 3 0 Integrase zinc binding domain RVT_2 PF07727.14 EEA19434.1 - 7.2e-11 42.2 0.0 1.3e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA19434.1 - 9.4e-08 32.3 0.3 4.5e-06 26.8 0.0 3.0 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 EEA19434.1 - 0.00017 21.4 0.2 0.0006 19.6 0.2 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA19434.1 - 0.12 12.6 0.0 0.61 10.3 0.0 2.2 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Integrase_H2C2 PF17921.1 EEA19434.1 - 1.5 9.0 9.6 0.38 10.9 0.1 3.7 3 0 0 3 3 3 0 Integrase zinc binding domain Dak1 PF02733.17 EEA19435.1 - 1e-75 254.5 0.0 5.7e-75 252.1 0.0 1.9 2 0 0 2 2 2 1 Dak1 domain Dak2 PF02734.17 EEA19435.1 - 4.6e-36 124.3 0.1 1.1e-35 123.1 0.1 1.6 1 0 0 1 1 1 1 DAK2 domain Spo0M PF07070.11 EEA19435.1 - 0.0018 17.9 0.1 0.0044 16.6 0.0 1.7 2 0 0 2 2 2 1 SpoOM protein FR47 PF08445.10 EEA19435.1 - 0.0044 17.0 0.2 0.0095 15.9 0.2 1.5 1 0 0 1 1 1 1 FR47-like protein Transketolase_N PF00456.21 EEA19436.1 - 1.1e-127 425.6 0.1 1.6e-127 425.1 0.1 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EEA19436.1 - 1.9e-37 128.7 0.0 5.1e-37 127.3 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EEA19436.1 - 7.4e-07 29.1 0.0 1.8e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EEA19436.1 - 3.3e-06 26.5 0.0 7.9e-06 25.3 0.0 1.7 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 EEA19436.1 - 4.9e-06 25.7 0.1 7.6e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EEA19436.1 - 0.00012 21.9 0.8 0.0088 15.8 1.5 3.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Toxin_ToxA PF11584.8 EEA19436.1 - 0.081 12.9 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA HET PF06985.11 EEA19437.1 - 6.9e-13 49.2 2.6 9e-11 42.3 0.0 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Ribosomal_S3Ae PF01015.18 EEA19437.1 - 0.086 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S3Ae family Trp_halogenase PF04820.14 EEA19437.1 - 0.14 11.0 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Closter_coat PF01785.17 EEA19438.1 - 0.1 11.8 2.4 0.17 11.1 0.4 2.1 2 0 0 2 2 2 0 Closterovirus coat protein CENP-O PF09496.10 EEA19439.1 - 6.5e-67 225.6 0.0 1.1e-66 224.8 0.0 1.4 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component TBK1_CCD1 PF18394.1 EEA19439.1 - 0.023 14.3 0.4 0.033 13.7 0.4 1.2 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 KASH_CCD PF14662.6 EEA19439.1 - 0.045 13.6 1.2 1.9 8.2 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Tnp_22_trimer PF17489.2 EEA19439.1 - 0.099 12.6 1.1 0.48 10.4 0.1 2.3 2 0 0 2 2 2 0 L1 transposable element trimerization domain Phage_Mu_Gam PF07352.12 EEA19439.1 - 0.11 12.4 1.6 0.81 9.6 0.1 2.1 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein DUF5082 PF16888.5 EEA19439.1 - 0.68 10.2 4.1 2.1 8.7 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) TMF_TATA_bd PF12325.8 EEA19439.1 - 0.86 9.8 3.7 1.3 9.3 0.6 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Goodbye PF17109.5 EEA19440.1 - 1.1e-08 35.6 0.0 1.1e-08 35.6 0.0 2.6 3 0 0 3 3 3 1 fungal STAND N-terminal Goodbye domain AAA_22 PF13401.6 EEA19440.1 - 3e-06 27.5 0.0 3.4e-05 24.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA19440.1 - 8.7e-05 23.0 0.0 0.00057 20.3 0.0 2.5 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 EEA19440.1 - 0.039 13.0 0.1 0.18 10.8 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein RMI1_N PF08585.12 EEA19440.1 - 0.86 9.3 3.5 0.91 9.2 1.2 2.3 2 0 0 2 2 2 0 RecQ mediated genome instability protein Acatn PF13000.7 EEA19441.1 - 4e-164 547.2 17.7 2.7e-84 283.7 7.0 3.1 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 DUF3176 PF11374.8 EEA19442.1 - 4.7e-21 75.0 0.0 1.1e-20 73.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) Nup188_C PF18378.1 EEA19442.1 - 0.0094 14.8 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Yae1_N PF09811.9 EEA19443.1 - 4.2e-13 48.8 0.1 9.2e-13 47.7 0.1 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal SCO1-SenC PF02630.14 EEA19446.1 - 4.6e-49 165.8 0.0 7.2e-49 165.1 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EEA19446.1 - 8.5e-05 22.5 0.0 0.00015 21.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EEA19446.1 - 0.014 15.7 0.0 0.029 14.7 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin-like MoaE PF02391.17 EEA19447.1 - 6.2e-32 110.2 0.0 9.7e-32 109.6 0.0 1.3 1 0 0 1 1 1 1 MoaE protein Polysacc_deac_1 PF01522.21 EEA19447.1 - 1.8e-20 73.1 0.0 3.5e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase ThuA PF06283.11 EEA19447.1 - 0.058 13.6 0.0 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 Trehalose utilisation DUF2334 PF10096.9 EEA19447.1 - 0.062 12.9 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) DEAD PF00270.29 EEA19448.1 - 1.5e-40 138.8 0.0 2.7e-40 138.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA19448.1 - 1.2e-28 99.6 0.0 5.1e-28 97.6 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EEA19448.1 - 0.00091 18.1 0.0 0.022 13.5 0.0 2.1 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ResIII PF04851.15 EEA19448.1 - 0.057 13.4 0.0 0.16 11.9 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Glyoxal_oxid_N PF07250.11 EEA19449.1 - 3.7e-36 124.5 0.0 1.3e-35 122.7 0.0 2.0 2 0 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EEA19449.1 - 2.1e-20 72.8 0.0 4.4e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Fumble PF03630.14 EEA19450.1 - 5e-144 479.5 0.1 6.2e-144 479.2 0.1 1.1 1 0 0 1 1 1 1 Fumble GPI2 PF06432.11 EEA19452.1 - 1.6e-133 444.5 4.5 1.8e-133 444.3 4.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF2975 PF11188.8 EEA19452.1 - 1.7 8.6 9.2 3.3 7.6 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) Gln-synt_C PF00120.24 EEA19453.1 - 1e-59 202.3 0.0 2.8e-59 200.8 0.0 1.7 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 EEA19453.1 - 1.7e-15 57.6 0.1 5.9e-15 55.8 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase HTH_43 PF09904.9 EEA19453.1 - 0.14 12.1 0.0 0.5 10.3 0.0 2.0 1 1 0 1 1 1 0 Winged helix-turn helix TPR_10 PF13374.6 EEA19454.1 - 3.9e-130 420.8 20.7 9.7e-11 41.2 0.1 13.5 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_12 PF13424.6 EEA19454.1 - 3.5e-125 408.5 56.6 1.8e-17 63.4 2.0 9.3 5 2 5 10 10 9 9 Tetratricopeptide repeat TPR_1 PF00515.28 EEA19454.1 - 5.8e-72 234.8 51.6 9.9e-06 25.2 0.4 13.6 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_2 PF07719.17 EEA19454.1 - 1.5e-51 168.3 44.2 0.00037 20.4 0.3 13.7 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_7 PF13176.6 EEA19454.1 - 1.5e-45 149.9 41.5 0.0013 18.6 0.1 13.2 13 0 0 13 13 12 12 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA19454.1 - 4.7e-39 134.7 15.5 3.7e-14 52.8 1.4 6.1 1 1 5 6 6 6 5 MalT-like TPR region TPR_8 PF13181.6 EEA19454.1 - 4.4e-37 123.2 46.5 0.014 15.6 0.2 13.8 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_16 PF13432.6 EEA19454.1 - 6.2e-37 126.0 49.0 0.011 16.4 0.7 14.2 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_14 PF13428.6 EEA19454.1 - 6.4e-36 120.0 18.9 0.24 12.3 0.0 13.9 13 0 0 13 13 13 7 Tetratricopeptide repeat TPR_17 PF13431.6 EEA19454.1 - 4.9e-23 79.8 30.5 0.52 10.8 0.2 15.0 13 1 0 13 13 13 4 Tetratricopeptide repeat TPR_19 PF14559.6 EEA19454.1 - 5.8e-14 52.4 37.9 0.0056 17.2 0.6 9.0 7 2 1 9 9 7 6 Tetratricopeptide repeat TPR_4 PF07721.14 EEA19454.1 - 8.4e-12 44.5 0.0 39 5.3 0.0 11.3 12 0 0 12 12 11 0 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 EEA19454.1 - 5.4e-11 42.2 0.2 1.2e-10 41.0 0.2 1.6 1 0 0 1 1 1 1 Phosphorylase superfamily DUF2225 PF09986.9 EEA19454.1 - 9.2e-10 38.6 14.9 0.1 12.3 0.5 6.5 1 1 3 6 6 6 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 EEA19454.1 - 4.5e-09 35.8 60.7 0.11 12.2 0.1 12.4 12 0 0 12 12 12 4 TPR repeat RPN7 PF10602.9 EEA19454.1 - 7.2e-09 35.6 16.6 6.4 6.4 0.1 10.6 3 3 8 12 12 12 0 26S proteasome subunit RPN7 PPR PF01535.20 EEA19454.1 - 9.9e-09 34.9 12.3 34 5.0 0.0 11.9 13 0 0 13 13 12 0 PPR repeat NB-ARC PF00931.22 EEA19454.1 - 2.9e-08 33.2 0.0 5.1e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_21 PF09976.9 EEA19454.1 - 3.2e-07 30.2 52.9 1.9 8.2 0.1 12.5 3 2 7 11 11 10 1 Tetratricopeptide repeat-like domain AAA_16 PF13191.6 EEA19454.1 - 3.5e-06 27.5 0.0 2.7e-05 24.6 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain Ribosomal_S7 PF00177.21 EEA19454.1 - 0.00028 20.6 0.0 34 4.1 0.0 6.4 1 1 4 6 6 6 0 Ribosomal protein S7p/S5e ATPase_2 PF01637.18 EEA19454.1 - 0.00043 20.3 0.0 0.0018 18.3 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea KIF1B PF12423.8 EEA19454.1 - 0.00092 19.6 0.8 4.9e+02 1.3 0.0 7.9 10 0 0 10 10 8 0 Kinesin protein 1B Strumpellin PF10266.9 EEA19454.1 - 0.001 16.9 0.2 2.3 5.8 0.0 4.4 3 2 3 6 6 6 1 Hereditary spastic paraplegia protein strumpellin AAA_22 PF13401.6 EEA19454.1 - 0.0036 17.6 0.0 0.0096 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EEA19454.1 - 0.0042 17.0 0.0 0.011 15.7 0.0 1.7 1 1 0 1 1 1 1 NACHT domain TPR_6 PF13174.6 EEA19454.1 - 0.011 16.3 67.6 5.3 7.9 0.5 13.6 14 0 0 14 14 13 0 Tetratricopeptide repeat GHL13 PF14883.6 EEA19454.1 - 0.018 14.1 7.4 3.6 6.6 0.0 6.0 4 4 3 7 7 7 0 Hypothetical glycosyl hydrolase family 13 AAA_33 PF13671.6 EEA19454.1 - 0.029 14.5 0.0 0.073 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF5344 PF17279.2 EEA19454.1 - 0.035 14.7 0.3 38 4.9 0.0 5.6 8 0 0 8 8 4 0 Family of unknown function (DUF5344) AAA_14 PF13173.6 EEA19454.1 - 0.042 13.9 0.0 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF4810 PF16068.5 EEA19454.1 - 0.052 14.1 36.9 43 4.7 0.1 11.4 11 1 0 12 12 12 0 Domain of unknown function (DUF4810) AAA_24 PF13479.6 EEA19454.1 - 0.053 13.2 0.5 0.64 9.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain CBP_BcsQ PF06564.12 EEA19454.1 - 0.063 12.8 0.1 0.51 9.8 0.0 2.4 3 0 0 3 3 2 0 Cellulose biosynthesis protein BcsQ DUF4388 PF14332.6 EEA19454.1 - 0.082 13.2 0.0 81 3.6 0.0 5.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4388) AAA PF00004.29 EEA19454.1 - 0.12 12.7 0.0 0.27 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF1754 PF08555.10 EEA19454.1 - 0.16 12.8 12.0 65 4.4 0.0 6.1 6 2 1 7 7 4 0 Eukaryotic family of unknown function (DUF1754) TniB PF05621.11 EEA19454.1 - 0.18 11.2 0.0 0.92 8.9 0.0 2.2 2 0 0 2 2 1 0 Bacterial TniB protein MIT PF04212.18 EEA19454.1 - 0.3 11.2 41.7 3.8 7.7 0.2 11.5 12 0 0 12 12 12 0 MIT (microtubule interacting and transport) domain APS_kinase PF01583.20 EEA19454.1 - 0.52 10.2 2.6 2.8 7.8 0.0 3.5 4 0 0 4 4 2 0 Adenylylsulphate kinase TPR_3 PF07720.12 EEA19454.1 - 0.66 10.0 35.3 9 6.4 0.1 11.1 12 0 0 12 12 12 0 Tetratricopeptide repeat Aldedh PF00171.22 EEA19455.1 - 1.3e-155 518.4 0.0 1.7e-155 518.1 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Glyco_hydro_18 PF00704.28 EEA19455.1 - 2e-62 211.7 0.4 3e-62 211.1 0.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EEA19455.1 - 6.5e-12 45.7 17.7 1.4e-11 44.7 17.7 1.6 1 0 0 1 1 1 1 Chitin recognition protein MFS_1 PF07690.16 EEA19457.1 - 5.2e-30 104.6 37.7 1e-28 100.3 26.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RAP PF08373.10 EEA19457.1 - 0.089 12.9 0.2 2.8 8.1 0.1 2.3 2 0 0 2 2 2 0 RAP domain TPP_enzyme_N PF02776.18 EEA19458.1 - 1.1e-36 126.1 2.5 3.2e-36 124.5 2.4 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EEA19458.1 - 1e-16 61.1 0.0 2.5e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA19458.1 - 4.2e-09 36.3 0.1 1.1e-08 34.8 0.1 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain MFS_1 PF07690.16 EEA19461.1 - 2.3e-36 125.5 27.8 1e-28 100.3 9.6 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19461.1 - 3.9e-15 55.7 3.7 3.9e-15 55.7 3.7 2.6 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EEA19461.1 - 0.0017 16.9 4.2 0.0029 16.1 4.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UPF0016 PF01169.19 EEA19462.1 - 8.6e-41 138.1 26.7 1.5e-20 73.3 11.7 2.4 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF2070 PF09843.9 EEA19462.1 - 0.016 13.6 1.3 0.028 12.7 1.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) YIEGIA PF14045.6 EEA19462.1 - 0.1 11.4 0.1 0.17 10.7 0.1 1.2 1 0 0 1 1 1 0 YIEGIA protein Myb_DNA-binding PF00249.31 EEA19463.1 - 3.9e-07 30.1 0.3 7.4e-07 29.3 0.3 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA19463.1 - 0.0029 17.8 0.2 0.0061 16.8 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3963 PF13124.6 EEA19463.1 - 0.27 11.2 0.0 0.71 9.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3963) Lipase_GDSL_2 PF13472.6 EEA19464.1 - 8.7e-15 55.6 0.0 1e-14 55.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EEA19464.1 - 8.8e-12 45.4 0.0 1.5e-11 44.6 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF1993 PF09351.10 EEA19465.1 - 1.9e-43 148.4 1.9 3.8e-43 147.4 1.9 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1993) DUF3422 PF11902.8 EEA19465.1 - 0.015 14.4 0.2 0.018 14.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) DHR-2 PF06920.13 EEA19465.1 - 0.035 12.7 0.1 0.042 12.5 0.1 1.1 1 0 0 1 1 1 0 Dock homology region 2 DinB_2 PF12867.7 EEA19465.1 - 0.076 13.5 0.0 0.09 13.3 0.0 1.2 1 0 0 1 1 1 0 DinB superfamily DUF848 PF05852.11 EEA19465.1 - 0.086 13.0 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) GPI-anchored PF10342.9 EEA19466.1 - 5.8e-05 23.8 0.0 5.8e-05 23.8 0.0 2.5 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family GPI-anchored PF10342.9 EEA19467.1 - 5.8e-05 23.8 0.0 5.8e-05 23.8 0.0 2.5 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Peptidase_M20 PF01546.28 EEA19468.1 - 2.7e-35 122.0 0.0 4e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA19468.1 - 1.3e-09 37.9 0.1 3.1e-09 36.7 0.1 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain AATase PF07247.12 EEA19469.1 - 7.2e-27 94.1 0.2 4.3e-26 91.5 0.2 1.9 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 EEA19469.1 - 0.00011 21.1 0.2 0.0071 15.1 0.0 2.2 2 0 0 2 2 2 2 Condensation domain Aldo_ket_red PF00248.21 EEA19470.1 - 2.4e-46 158.3 0.0 2.8e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Peptidase_S9 PF00326.21 EEA19470.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family WSC PF01822.19 EEA19471.1 - 2.6e-14 53.2 6.9 2.6e-14 53.2 6.9 1.7 2 0 0 2 2 2 1 WSC domain Annexin PF00191.20 EEA19472.1 - 3.2e-12 46.3 3.1 0.012 15.7 0.0 4.6 4 0 0 4 4 4 4 Annexin DUF3915 PF13054.6 EEA19472.1 - 0.01 15.8 1.5 0.01 15.8 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) MFS_1 PF07690.16 EEA19473.1 - 6e-31 107.6 26.8 6e-31 107.6 26.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1129 PF06570.11 EEA19473.1 - 0.24 10.8 1.8 0.45 10.0 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) Zn_clus PF00172.18 EEA19474.1 - 2.8e-08 33.8 4.0 5e-08 32.9 4.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA19474.1 - 0.029 13.4 0.0 0.077 12.0 0.0 1.7 1 0 0 1 1 1 0 Fungal specific transcription factor domain SlyX PF04102.12 EEA19474.1 - 0.12 13.0 0.6 0.86 10.3 0.1 2.2 2 0 0 2 2 2 0 SlyX TauD PF02668.16 EEA19475.1 - 3e-43 148.6 1.7 3.6e-43 148.3 1.7 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family ABM PF03992.16 EEA19475.1 - 2.3 8.4 4.8 0.63 10.2 0.8 2.2 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase Septin PF00735.18 EEA19476.1 - 1e-33 116.9 0.1 1.1e-11 44.6 0.0 3.2 3 0 0 3 3 3 3 Septin FtsK_SpoIIIE PF01580.18 EEA19476.1 - 0.0005 19.5 0.0 0.0011 18.4 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family BSP_II PF05432.11 EEA19476.1 - 0.00086 19.1 4.0 0.00086 19.1 4.0 1.4 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) CDC45 PF02724.14 EEA19476.1 - 0.0017 16.8 0.9 0.0017 16.8 0.9 1.9 2 0 0 2 2 2 1 CDC45-like protein DUF4637 PF15470.6 EEA19476.1 - 0.0082 15.9 5.5 0.0082 15.9 5.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4637) AAA_15 PF13175.6 EEA19476.1 - 0.026 14.3 0.0 0.068 12.9 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EEA19476.1 - 0.038 14.1 0.0 0.093 12.8 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 EEA19476.1 - 0.053 13.6 4.2 0.21 11.6 0.2 2.9 2 1 0 2 2 2 0 Dynamin family AAA_16 PF13191.6 EEA19476.1 - 0.063 13.7 0.1 0.75 10.2 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 EEA19476.1 - 0.066 12.4 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 G-protein alpha subunit Nop14 PF04147.12 EEA19476.1 - 0.29 9.3 11.5 0.5 8.5 11.5 1.3 1 0 0 1 1 1 0 Nop14-like family DUF2052 PF09747.9 EEA19476.1 - 0.3 11.2 12.2 0.087 12.9 6.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RRN3 PF05327.11 EEA19476.1 - 2.9 6.3 8.6 4.2 5.8 8.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EEA19476.1 - 5.1 5.1 17.4 7.4 4.5 17.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Vps62 PF06101.11 EEA19477.1 - 1.5e-12 46.6 4.0 1.8e-12 46.4 2.2 1.8 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 62 Macoilin PF09726.9 EEA19478.1 - 1.8 7.0 13.3 1.9 7.0 13.3 1.1 1 0 0 1 1 1 0 Macoilin family Fez1 PF06818.15 EEA19479.1 - 0.001 19.6 16.5 0.016 15.7 16.5 2.1 1 1 0 1 1 1 1 Fez1 Prefoldin PF02996.17 EEA19479.1 - 0.001 18.9 11.4 0.0014 18.5 1.4 3.4 1 1 2 3 3 3 1 Prefoldin subunit DUF948 PF06103.11 EEA19479.1 - 0.0026 18.0 4.6 0.0035 17.6 2.6 2.0 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) TPR_MLP1_2 PF07926.12 EEA19479.1 - 0.024 14.7 8.2 0.024 14.7 8.2 2.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein BLOC1_2 PF10046.9 EEA19479.1 - 0.03 14.6 5.7 0.03 14.6 5.7 2.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.12 EEA19479.1 - 0.051 14.2 18.5 0.16 12.6 1.9 3.6 2 1 1 3 3 3 0 SlyX OmpH PF03938.14 EEA19479.1 - 0.066 13.5 15.0 0.56 10.5 7.0 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Kre28 PF17097.5 EEA19479.1 - 0.14 11.1 6.4 0.63 8.9 6.4 1.9 1 1 0 1 1 1 0 Spindle pole body component Spc7 PF08317.11 EEA19479.1 - 0.17 10.7 18.1 0.37 9.6 8.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 EEA19479.1 - 0.31 10.4 12.0 0.65 9.3 12.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EEA19479.1 - 0.48 10.5 7.4 0.46 10.5 4.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TPD52 PF04201.15 EEA19479.1 - 0.54 9.8 7.0 4.5 6.9 0.2 2.7 1 1 1 2 2 2 0 Tumour protein D52 family DUF3552 PF12072.8 EEA19479.1 - 0.94 8.9 18.8 2.5 7.5 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) DUF724 PF05266.14 EEA19479.1 - 1.1 9.0 13.0 3.4 7.5 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF724) zf-C4H2 PF10146.9 EEA19479.1 - 1.1 9.5 7.3 1.9 8.7 6.7 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein Lzipper-MIP1 PF14389.6 EEA19479.1 - 1.5 9.2 17.4 1.2 9.4 9.3 3.1 2 1 1 3 3 2 0 Leucine-zipper of ternary complex factor MIP1 BST2 PF16716.5 EEA19479.1 - 2.3 8.9 16.8 1.3 9.6 7.9 3.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 ADIP PF11559.8 EEA19479.1 - 2.5 8.1 16.8 2.6 8.1 0.8 3.0 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding ABC_tran_CTD PF16326.5 EEA19479.1 - 2.6 8.3 26.5 0.087 13.1 6.6 4.8 3 1 2 5 5 4 0 ABC transporter C-terminal domain DUF1043 PF06295.12 EEA19479.1 - 2.7 8.0 8.7 7.6 6.6 8.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) YabA PF06156.13 EEA19479.1 - 2.9 8.6 9.5 26 5.5 0.1 3.0 2 1 0 2 2 2 0 Initiation control protein YabA Laminin_II PF06009.12 EEA19479.1 - 3.2 7.8 10.1 3.5 7.7 4.3 2.3 2 0 0 2 2 2 0 Laminin Domain II Atg14 PF10186.9 EEA19479.1 - 3.3 6.7 13.4 27 3.7 13.4 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lebercilin PF15619.6 EEA19479.1 - 3.5 7.2 21.8 2.1 8.0 10.1 2.5 3 0 0 3 3 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4140 PF13600.6 EEA19479.1 - 3.7 8.0 18.2 3.4 8.2 0.9 3.8 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) UPF0449 PF15136.6 EEA19479.1 - 3.8 8.0 7.9 1.3 9.6 1.9 2.8 1 1 2 3 3 3 0 Uncharacterised protein family UPF0449 AAA_13 PF13166.6 EEA19479.1 - 4.3 5.9 11.5 17 3.9 11.5 1.8 1 1 0 1 1 1 0 AAA domain Prefoldin_2 PF01920.20 EEA19479.1 - 4.6 7.2 15.1 0.57 10.2 3.6 3.4 2 2 1 3 3 3 0 Prefoldin subunit HIP1_clath_bdg PF16515.5 EEA19479.1 - 5.6 7.6 15.0 12 6.6 7.2 2.8 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-Q PF13094.6 EEA19479.1 - 7.6 6.7 23.6 0.99 9.6 6.6 2.6 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit BRE1 PF08647.11 EEA19479.1 - 7.9 6.6 15.0 5.5 7.1 1.1 3.2 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Cob_adeno_trans PF01923.18 EEA19479.1 - 9.7 6.3 8.2 10 6.2 5.2 2.2 1 1 1 2 2 2 0 Cobalamin adenosyltransferase S4 PF01479.25 EEA19480.1 - 1.1e-12 47.5 0.8 1.1e-12 47.5 0.8 2.4 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 EEA19480.1 - 2.7e-06 28.2 0.2 5.4e-06 27.2 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 EEA19481.1 - 1.7e-44 149.8 2.4 2.8e-44 149.1 2.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e Mito_carr PF00153.27 EEA19482.1 - 8.8e-74 243.5 1.9 5.5e-24 83.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein AA_permease_2 PF13520.6 EEA19485.1 - 8.1e-60 202.8 53.8 1e-59 202.5 53.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA19485.1 - 2.5e-28 98.9 46.4 3.4e-28 98.5 46.4 1.0 1 0 0 1 1 1 1 Amino acid permease p450 PF00067.22 EEA19486.1 - 5.5e-41 140.8 0.0 8.9e-41 140.1 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Glyco_hydro_43 PF04616.14 EEA19488.1 - 8.7e-36 123.7 0.0 1.1e-35 123.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 MFS_1 PF07690.16 EEA19489.1 - 3.3e-37 128.2 29.9 3.3e-37 128.2 29.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19489.1 - 9.6e-13 47.8 6.4 9.6e-13 47.8 6.4 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter Alpha_kinase PF02816.18 EEA19490.1 - 2.4e-49 168.0 0.2 3.1e-49 167.6 0.2 1.1 1 0 0 1 1 1 1 Alpha-kinase family Ifi-6-16 PF06140.13 EEA19491.1 - 1.7e-06 27.8 22.9 1.1e-05 25.2 22.8 2.0 1 1 0 1 1 1 1 Interferon-induced 6-16 family CD99L2 PF12301.8 EEA19491.1 - 4.1 7.7 5.2 5.2 7.3 5.2 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 Fungal_trans PF04082.18 EEA19492.1 - 2.6e-16 59.4 0.2 3.7e-10 39.3 0.0 2.3 1 1 1 2 2 2 2 Fungal specific transcription factor domain zf-C2H2_12 PF18658.1 EEA19493.1 - 0.045 13.3 0.8 0.082 12.5 0.0 1.9 2 0 0 2 2 2 0 Zinc-finger C2H2-type RRM_1 PF00076.22 EEA19494.1 - 0.027 14.3 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SecE PF00584.20 EEA19495.1 - 2.9e-15 55.9 0.0 3.4e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex WD40 PF00400.32 EEA19496.1 - 2.6e-23 81.9 13.9 7.6e-05 23.4 0.1 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19496.1 - 9.3e-05 22.7 0.0 0.11 12.9 0.0 4.0 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EEA19496.1 - 0.00026 19.6 2.4 0.055 12.0 0.1 3.8 4 0 0 4 4 4 1 Cytochrome D1 heme domain PQQ_3 PF13570.6 EEA19496.1 - 0.0011 19.4 0.4 0.2 12.2 0.1 3.6 3 0 0 3 3 3 1 PQQ-like domain MFS_1 PF07690.16 EEA19497.1 - 7.3e-24 84.3 47.6 4.6e-22 78.4 42.7 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA19497.1 - 2.2e-06 26.4 26.0 4.5e-06 25.4 26.0 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ECH_1 PF00378.20 EEA19498.1 - 4e-54 183.6 0.0 4.9e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA19498.1 - 8.3e-31 107.7 0.3 2.1e-27 96.5 0.1 2.5 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DoxD PF04173.13 EEA19498.1 - 0.031 14.2 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 TQO small subunit DoxD PrpR_N PF06506.11 EEA19498.1 - 0.036 13.7 0.0 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Propionate catabolism activator DUF4819 PF16090.5 EEA19498.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4819) Acetyltransf_8 PF13523.6 EEA19499.1 - 5.3e-41 139.7 0.1 7.3e-41 139.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ABC_membrane PF00664.23 EEA19500.1 - 7.9e-91 304.5 24.6 1.1e-51 176.1 7.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA19500.1 - 1.8e-62 209.9 0.0 6.9e-31 107.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EEA19500.1 - 9.1e-16 58.0 3.6 3.5e-06 26.6 0.8 4.5 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA19500.1 - 1.2e-08 34.5 0.7 0.0028 17.3 0.0 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA19500.1 - 1.1e-07 32.4 1.4 0.011 16.1 0.1 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA19500.1 - 1.7e-07 31.6 1.6 0.12 12.6 0.1 4.2 2 2 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EEA19500.1 - 4.7e-06 26.5 0.8 0.052 13.3 0.0 3.5 3 1 0 3 3 3 2 AAA domain APS_kinase PF01583.20 EEA19500.1 - 1.1e-05 25.4 0.1 0.013 15.4 0.1 2.5 2 0 0 2 2 2 2 Adenylylsulphate kinase DUF87 PF01935.17 EEA19500.1 - 5.4e-05 23.4 2.3 0.047 13.8 0.7 3.0 2 1 0 2 2 2 2 Helicase HerA, central domain Zeta_toxin PF06414.12 EEA19500.1 - 9e-05 21.8 0.0 0.3 10.3 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin RsgA_GTPase PF03193.16 EEA19500.1 - 0.00012 22.0 0.1 0.06 13.2 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase DUF3987 PF13148.6 EEA19500.1 - 0.00036 19.7 0.0 0.068 12.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) AAA_33 PF13671.6 EEA19500.1 - 0.0017 18.6 0.0 2.9 8.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EEA19500.1 - 0.0017 18.9 0.0 3.9 8.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EEA19500.1 - 0.0017 18.0 0.3 0.68 9.5 0.0 3.6 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 EEA19500.1 - 0.0024 18.3 0.6 45 4.5 0.0 4.3 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EEA19500.1 - 0.0029 17.5 1.0 0.25 11.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EEA19500.1 - 0.0057 15.5 0.4 0.18 10.6 0.0 2.7 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 EEA19500.1 - 0.0072 16.9 4.8 1.3 9.4 0.0 2.8 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 EEA19500.1 - 0.0074 16.4 0.0 3.8 7.6 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase SbcCD_C PF13558.6 EEA19500.1 - 0.011 16.0 0.2 14 6.0 0.2 3.5 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 EEA19500.1 - 0.011 15.7 0.0 4.9 7.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 EEA19500.1 - 0.015 15.1 0.1 0.27 11.0 0.0 2.7 2 1 0 2 2 2 0 DEAD/DEAH box helicase SRP54 PF00448.22 EEA19500.1 - 0.02 14.5 0.0 7.2 6.2 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NB-ARC PF00931.22 EEA19500.1 - 0.032 13.4 0.1 7 5.7 0.0 2.6 3 0 0 3 3 2 0 NB-ARC domain KdpD PF02702.17 EEA19500.1 - 0.045 13.2 0.0 2.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Osmosensitive K+ channel His kinase sensor domain AAA_7 PF12775.7 EEA19500.1 - 0.066 12.7 0.1 10 5.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Cad PF03596.13 EEA19500.1 - 0.09 12.7 4.8 0.34 10.8 0.8 3.0 2 0 0 2 2 2 0 Cadmium resistance transporter AAA_24 PF13479.6 EEA19500.1 - 0.16 11.7 0.0 7.7 6.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EEA19500.1 - 0.16 12.4 0.0 37 4.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AMP-binding PF00501.28 EEA19501.1 - 5e-68 229.6 0.1 7.3e-64 215.9 0.0 2.4 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EEA19501.1 - 8.7e-67 225.8 0.0 4.4e-36 124.5 0.0 2.6 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EEA19501.1 - 1.7e-28 98.8 0.3 4.4e-13 49.4 0.1 3.3 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA19501.1 - 0.00019 22.3 0.0 0.12 13.4 0.0 3.3 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Symplekin_C PF12295.8 EEA19501.1 - 0.12 12.5 0.2 0.36 10.9 0.0 1.8 2 0 0 2 2 2 0 Symplekin tight junction protein C terminal DUF1749 PF08538.10 EEA19502.1 - 1.2e-96 323.3 0.0 1.5e-96 323.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EEA19502.1 - 0.0087 16.7 0.0 0.013 16.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19502.1 - 0.01 15.1 0.0 0.024 13.9 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA19502.1 - 0.016 14.8 0.0 0.031 13.9 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF5089 PF17002.5 EEA19502.1 - 0.025 14.4 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) COesterase PF00135.28 EEA19502.1 - 0.08 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family DUF900 PF05990.12 EEA19502.1 - 0.1 12.1 0.0 0.33 10.4 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 EEA19502.1 - 0.14 11.6 0.0 0.45 10.0 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase PGAP1 PF07819.13 EEA19502.1 - 0.19 11.4 0.1 1.4 8.6 0.2 2.4 1 1 1 2 2 2 0 PGAP1-like protein DUF1749 PF08538.10 EEA19503.1 - 8.7e-93 310.7 0.0 1.1e-92 310.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EEA19503.1 - 0.0088 16.7 0.0 0.013 16.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19503.1 - 0.011 15.1 0.0 0.024 13.9 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA19503.1 - 0.015 14.9 0.0 0.029 14.0 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF5089 PF17002.5 EEA19503.1 - 0.025 14.5 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) COesterase PF00135.28 EEA19503.1 - 0.063 12.1 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Carboxylesterase family DUF900 PF05990.12 EEA19503.1 - 0.1 12.1 0.0 0.33 10.4 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 EEA19503.1 - 0.17 11.4 0.0 0.45 10.0 0.0 1.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase PGAP1 PF07819.13 EEA19503.1 - 0.19 11.4 0.1 1.7 8.3 0.2 2.4 1 1 1 2 2 2 0 PGAP1-like protein adh_short PF00106.25 EEA19504.1 - 2.1e-20 73.0 0.0 3.9e-18 65.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19504.1 - 9.2e-14 51.6 0.0 2.2e-12 47.1 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19504.1 - 5e-06 26.6 0.0 8.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EEA19504.1 - 0.0042 17.1 0.0 0.0074 16.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF3073 PF11273.8 EEA19504.1 - 0.047 14.4 0.2 5.1 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) GHMP_kinases_C PF08544.13 EEA19504.1 - 0.05 14.0 0.1 0.14 12.5 0.1 1.8 1 0 0 1 1 1 0 GHMP kinases C terminal Fungal_trans_2 PF11951.8 EEA19505.1 - 9.1e-11 41.2 0.8 2.3e-07 30.0 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Aldo_ket_red PF00248.21 EEA19506.1 - 1.2e-73 247.9 0.0 1.4e-73 247.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DnaB_C PF03796.15 EEA19506.1 - 0.11 11.9 0.0 12 5.1 0.0 2.1 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain PX PF00787.24 EEA19507.1 - 1.1e-27 96.3 0.2 1.3e-27 96.1 0.2 1.1 1 0 0 1 1 1 1 PX domain Myb_DNA-bind_6 PF13921.6 EEA19508.1 - 5.4e-16 58.6 0.0 4.3e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA19508.1 - 1.9e-14 53.6 0.1 1.4e-06 28.4 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain FXR_C1 PF16096.5 EEA19508.1 - 0.0034 17.6 3.3 0.033 14.4 0.0 3.5 4 0 0 4 4 4 1 Fragile X-related 1 protein C-terminal region 2 SLIDE PF09111.10 EEA19508.1 - 0.049 13.6 0.0 16 5.6 0.0 2.5 2 0 0 2 2 2 0 SLIDE Biliv-reduc_cat PF09166.10 EEA19509.1 - 0.22 11.9 0.1 0.33 11.3 0.1 1.3 1 0 0 1 1 1 0 Biliverdin reductase, catalytic Ank_2 PF12796.7 EEA19510.1 - 2.5e-74 245.9 18.7 1.1e-14 54.8 0.0 7.7 3 3 4 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19510.1 - 2.6e-51 171.4 11.0 1.7e-08 34.8 0.3 10.4 7 3 4 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA19510.1 - 1.3e-48 162.4 15.3 6.9e-08 32.6 0.3 11.6 3 3 9 12 12 12 12 Ankyrin repeats (many copies) Ank PF00023.30 EEA19510.1 - 2.3e-45 151.1 25.6 5.6e-08 32.9 0.2 13.0 12 0 0 12 12 11 8 Ankyrin repeat Ank_3 PF13606.6 EEA19510.1 - 4.7e-38 124.9 16.2 2.2e-06 27.6 0.1 14.5 14 0 0 14 14 14 6 Ankyrin repeat AAA_22 PF13401.6 EEA19510.1 - 5.3e-07 30.0 0.7 2.5e-06 27.8 0.0 2.5 2 1 0 3 3 3 1 AAA domain ZZ PF00569.17 EEA19510.1 - 0.00028 20.6 10.7 0.00053 19.7 10.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Helo_like_N PF17111.5 EEA19510.1 - 0.00099 18.5 0.3 0.0024 17.3 0.3 1.7 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins C1_2 PF03107.16 EEA19510.1 - 0.0027 18.0 3.9 0.0055 17.0 3.9 1.5 1 0 0 1 1 1 1 C1 domain AAA_16 PF13191.6 EEA19510.1 - 0.0027 18.1 0.0 0.011 16.2 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EEA19510.1 - 0.0039 17.1 0.1 0.016 15.1 0.1 2.0 1 1 0 1 1 1 1 NACHT domain Methyltrans_Mon PF14314.6 EEA19510.1 - 0.11 10.5 0.2 0.16 9.9 0.2 1.2 1 0 0 1 1 1 0 Virus-capping methyltransferase TM_helix PF05552.12 EEA19510.1 - 0.17 11.9 0.2 0.42 10.6 0.2 1.7 1 0 0 1 1 1 0 Conserved TM helix RasGEF PF00617.19 EEA19511.1 - 5.5e-10 39.7 0.2 1.2e-09 38.6 0.2 1.6 1 0 0 1 1 1 1 RasGEF domain RNase_H PF00075.24 EEA19512.1 - 3e-22 79.3 0.2 4.5e-22 78.8 0.2 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EEA19512.1 - 4.6e-07 29.7 0.0 0.027 14.3 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase-like NTPase_I-T PF01931.18 EEA19512.1 - 0.13 12.0 0.0 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF84 Ribosomal_S4e PF00900.20 EEA19513.1 - 7.2e-37 125.1 0.1 1.6e-36 124.1 0.1 1.6 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EEA19513.1 - 5.7e-25 86.7 0.1 9.9e-25 85.9 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EEA19513.1 - 2.5e-17 62.7 5.2 4.7e-17 61.8 5.2 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 EEA19513.1 - 1.2e-06 28.2 0.0 2.2e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EEA19513.1 - 0.00015 21.6 2.9 0.00015 21.6 2.9 3.1 4 0 0 4 4 4 1 KOW motif Semialdhyde_dhC PF02774.18 EEA19514.1 - 3.7e-35 121.7 0.0 5e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EEA19514.1 - 1.5e-29 102.9 0.0 3.6e-29 101.7 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 EEA19515.1 - 3.7e-35 121.7 0.0 5e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EEA19515.1 - 1.5e-29 102.9 0.0 3.6e-29 101.7 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain FAD-oxidase_C PF02913.19 EEA19516.1 - 1.7e-66 224.5 0.0 2.4e-66 223.9 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EEA19516.1 - 5.7e-34 116.8 0.0 1.2e-33 115.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain SepSecS PF05889.13 EEA19516.1 - 0.062 12.0 0.0 0.11 11.1 0.0 1.4 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS ATG16 PF08614.11 EEA19517.1 - 0.0014 18.9 12.2 0.0014 18.9 12.2 4.2 2 1 2 4 4 4 1 Autophagy protein 16 (ATG16) GAS PF13851.6 EEA19517.1 - 1.3 8.3 58.6 0.084 12.2 17.2 3.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding TSC22 PF01166.18 EEA19517.1 - 8.4 6.8 11.8 0.54 10.6 1.3 4.2 2 2 2 4 4 4 0 TSC-22/dip/bun family RdRP PF05183.12 EEA19518.1 - 3.4e-194 646.8 0.0 4.6e-194 646.4 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase Xol-1_GHMP-like PF09109.10 EEA19518.1 - 0.006 16.5 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Switch protein XOL-1, GHMP-like ELP6 PF09807.9 EEA19519.1 - 1.3e-10 41.1 0.0 7.5e-06 25.6 0.0 2.2 2 0 0 2 2 2 2 Elongation complex protein 6 Nro1 PF12753.7 EEA19519.1 - 0.13 11.2 0.2 0.17 10.8 0.2 1.1 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Ribosomal_L37e PF01907.19 EEA19520.1 - 5.5e-29 100.1 12.9 8.1e-29 99.6 12.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 EEA19520.1 - 0.0069 16.4 1.9 0.011 15.8 1.9 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF35_N PF12172.8 EEA19520.1 - 0.071 13.0 2.4 0.13 12.2 2.4 1.4 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HypA PF01155.19 EEA19520.1 - 0.12 12.5 1.0 0.15 12.1 1.0 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 EEA19520.1 - 0.18 11.6 3.9 6.3 6.7 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 EEA19520.1 - 0.19 11.2 3.8 0.67 9.4 3.8 1.8 1 1 0 1 1 1 0 zinc-ribbon domain DUF2688 PF10892.8 EEA19520.1 - 1 8.9 5.7 2.7 7.5 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) zf-HYPF PF07503.12 EEA19520.1 - 4.6 7.1 10.7 9.2 6.1 5.7 3.0 2 1 1 3 3 3 0 HypF finger EthD PF07110.11 EEA19522.1 - 1.3e-19 71.1 0.4 1.6e-19 70.8 0.4 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EEA19522.1 - 0.021 15.3 0.4 0.12 12.8 0.4 2.0 1 1 0 1 1 1 0 Methylmuconolactone methyl-isomerase Slu7 PF11708.8 EEA19523.1 - 6.6e-83 278.6 20.3 6.6e-83 278.6 20.3 2.7 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 EEA19523.1 - 0.017 14.9 0.4 0.071 12.9 0.6 2.0 2 0 0 2 2 2 0 Zinc knuckle DNA_pol_B PF00136.21 EEA19524.1 - 8.4e-100 334.6 0.0 1.2e-99 334.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EEA19524.1 - 1.6e-21 76.8 0.0 2.4e-11 43.4 0.0 2.6 2 1 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EEA19524.1 - 2.4e-18 66.4 5.7 2.4e-18 66.4 5.7 1.9 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta Cript PF10235.9 EEA19524.1 - 0.11 13.0 0.2 0.35 11.5 0.2 1.8 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT PHD PF00628.29 EEA19524.1 - 0.41 10.6 2.5 0.92 9.5 2.5 1.7 1 0 0 1 1 1 0 PHD-finger Sugar_tr PF00083.24 EEA19525.1 - 1e-120 403.7 16.0 1.6e-120 403.0 16.0 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19525.1 - 1.7e-24 86.5 42.0 3.2e-14 52.6 17.3 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA19525.1 - 0.0007 18.1 1.2 0.0007 18.1 1.2 2.4 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) DUF3382 PF11862.8 EEA19525.1 - 7.1 7.0 9.2 0.6 10.4 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) Sugar_tr PF00083.24 EEA19526.1 - 1.9e-117 392.9 17.5 3.4e-117 392.1 17.5 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19526.1 - 1.6e-22 79.9 47.1 2.8e-14 52.8 17.3 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA19526.1 - 0.00062 18.3 1.2 0.00062 18.3 1.2 2.4 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) DUF3382 PF11862.8 EEA19526.1 - 0.55 10.5 0.1 0.55 10.5 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) Fungal_trans PF04082.18 EEA19527.1 - 4.8e-26 91.4 1.6 5.2e-26 91.3 0.5 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19527.1 - 5.5e-10 39.2 9.8 9.8e-10 38.4 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EEA19527.1 - 7.3e-06 26.1 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Gal4-like dimerisation domain DJ-1_PfpI PF01965.24 EEA19528.1 - 2.5e-16 59.9 0.0 3e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family COX6A PF02046.15 EEA19529.1 - 1.2e-51 173.9 1.8 1.4e-51 173.7 1.8 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa COX6A PF02046.15 EEA19530.1 - 3.1e-44 150.0 0.1 3.6e-44 149.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Exo_endo_phos PF03372.23 EEA19531.1 - 7e-13 48.6 0.1 1.1e-12 47.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EEA19531.1 - 9.1e-05 22.5 0.7 0.00022 21.3 0.7 1.7 1 0 0 1 1 1 1 GRF zinc finger HMG_box PF00505.19 EEA19532.1 - 7.1e-21 74.4 0.3 1.3e-20 73.6 0.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA19532.1 - 7.4e-06 26.5 0.4 1.5e-05 25.5 0.4 1.6 1 0 0 1 1 1 1 HMG-box domain ANTH PF07651.16 EEA19534.1 - 4.2e-72 242.5 0.0 4.2e-72 242.5 0.0 3.1 3 1 0 3 3 3 1 ANTH domain I_LWEQ PF01608.17 EEA19534.1 - 6.7e-56 188.8 7.7 6.7e-56 188.8 7.7 6.1 5 2 0 6 6 6 1 I/LWEQ domain TAF8_C PF10406.9 EEA19534.1 - 0.94 10.1 3.6 6.4 7.4 3.6 2.6 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term MMM1 PF10296.9 EEA19535.1 - 5.2e-05 22.5 0.0 0.00012 21.3 0.0 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 PH_11 PF15413.6 EEA19535.1 - 0.0031 17.9 0.0 0.014 15.8 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EEA19535.1 - 0.062 13.8 0.0 0.47 11.0 0.0 2.4 3 0 0 3 3 3 0 PH domain Ank_2 PF12796.7 EEA19536.1 - 1.7e-24 86.2 3.1 3.8e-09 37.0 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19536.1 - 1.2e-21 76.7 5.6 5.7e-10 39.5 0.3 4.1 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA19536.1 - 2.2e-17 62.9 6.8 5.4e-05 23.4 0.2 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19536.1 - 2.8e-15 54.9 6.7 0.0071 16.8 0.1 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EEA19536.1 - 1.4e-14 53.8 16.6 0.0057 17.0 0.1 5.3 4 2 1 5 5 5 4 Ankyrin repeat Peptidase_C65 PF10275.9 EEA19537.1 - 4.5e-56 190.0 0.0 5.6e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain PCI PF01399.27 EEA19538.1 - 4.6e-21 75.3 0.5 4.6e-21 75.3 0.5 1.9 2 0 0 2 2 2 1 PCI domain TPR_1 PF00515.28 EEA19538.1 - 0.0018 18.1 0.4 0.018 14.8 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA19538.1 - 0.0024 17.8 3.0 0.17 12.0 0.0 4.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA19538.1 - 0.0058 16.3 0.4 0.022 14.5 0.1 2.2 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 EEA19538.1 - 0.016 15.2 0.1 0.016 15.2 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA19538.1 - 0.021 15.1 1.3 0.46 10.8 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA19538.1 - 0.071 14.0 2.0 1.5 9.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA19538.1 - 0.21 11.9 1.7 1.8 9.0 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CWC25 PF12542.8 EEA19539.1 - 2.3e-26 92.7 0.8 2.3e-26 92.7 0.8 4.0 2 2 1 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.9 EEA19539.1 - 3.1e-12 46.5 10.0 3.1e-12 46.5 10.0 3.5 5 0 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR PCI PF01399.27 EEA19540.1 - 4.8e-23 81.7 0.0 2.2e-22 79.6 0.0 2.1 1 0 0 1 1 1 1 PCI domain RPN5_C PF18098.1 EEA19540.1 - 4.7e-16 58.6 0.6 1.3e-15 57.2 0.6 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain KORA PF16509.5 EEA19540.1 - 0.039 14.2 0.6 1.9 8.8 0.2 2.8 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor FSH1 PF03959.13 EEA19541.1 - 4.3e-67 225.9 0.0 5.6e-67 225.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EEA19541.1 - 1.2e-06 29.3 0.7 4.9e-06 27.3 0.7 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Patched PF02460.18 EEA19542.1 - 0.11 10.6 0.0 0.13 10.3 0.0 1.0 1 0 0 1 1 1 0 Patched family Ribosomal_S27e PF01667.17 EEA19543.1 - 1e-28 98.8 6.7 1.3e-28 98.5 6.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 zf-C2HC5 PF06221.13 EEA19543.1 - 0.52 10.3 5.9 2 8.4 4.2 2.3 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type CDP-OH_P_transf PF01066.21 EEA19544.1 - 1.8e-17 63.8 0.2 1.8e-17 63.8 0.2 3.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase NIPSNAP PF07978.13 EEA19545.1 - 7.6e-40 135.3 5.8 1.4e-28 99.1 0.1 2.5 3 0 0 3 3 3 2 NIPSNAP MAS20 PF02064.15 EEA19545.1 - 0.14 12.3 0.9 0.25 11.5 0.9 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor TMA7 PF09072.10 EEA19545.1 - 1.4 9.8 4.1 9.3 7.2 4.1 2.1 1 1 0 1 1 1 0 Translation machinery associated TMA7 Putative_PNPOx PF01243.20 EEA19546.1 - 8.8e-12 45.1 0.0 2.2e-11 43.8 0.0 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EEA19546.1 - 0.062 13.3 0.0 0.13 12.2 0.0 1.5 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase BPL_LplA_LipB PF03099.19 EEA19547.1 - 3.8e-05 23.6 0.0 9.4e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family Ras PF00071.22 EEA19548.1 - 4.4e-52 175.9 0.0 5.1e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA19548.1 - 1.2e-20 73.9 0.0 2.3e-20 73.0 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA19548.1 - 1.2e-09 37.8 0.0 1.5e-09 37.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA19548.1 - 0.0013 18.2 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EEA19548.1 - 0.092 11.9 0.0 0.13 11.4 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit SRPRB PF09439.10 EEA19548.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EEA19548.1 - 0.19 11.8 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Abhydrolase_3 PF07859.13 EEA19549.1 - 5.6e-14 52.5 0.0 7.7e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA19549.1 - 1.4e-06 27.9 0.0 0.0028 17.2 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA19549.1 - 0.00013 21.3 0.0 0.00056 19.2 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EEA19549.1 - 0.00072 18.5 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme AXE1 PF05448.12 EEA19549.1 - 0.0016 17.2 0.0 0.41 9.3 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) COesterase PF00135.28 EEA19549.1 - 0.0042 16.0 0.0 0.011 14.6 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_1 PF00561.20 EEA19549.1 - 0.098 12.3 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 EEA19549.1 - 0.2 11.3 0.0 0.44 10.1 0.0 1.5 2 0 0 2 2 2 0 Putative esterase TP_methylase PF00590.20 EEA19550.1 - 5.4e-49 167.0 0.0 2.4e-46 158.3 0.0 2.2 2 0 0 2 2 2 2 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 EEA19550.1 - 1.9e-18 66.8 0.0 3.8e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EEA19550.1 - 2.3e-14 52.8 0.7 7.4e-09 35.1 0.1 2.7 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EEA19550.1 - 1.3e-07 31.0 0.1 2.7e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central preATP-grasp_3 PF18301.1 EEA19550.1 - 0.093 13.0 0.0 0.35 11.2 0.0 2.0 1 0 0 1 1 1 0 pre ATP-grasp 3 domain ABC_tran PF00005.27 EEA19551.1 - 1e-45 155.6 0.1 3.1e-29 102.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA19551.1 - 1.1e-27 97.3 15.4 1.1e-27 97.3 15.4 2.8 2 1 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EEA19551.1 - 1e-14 54.5 4.4 4.6e-06 26.2 0.1 4.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA19551.1 - 8.5e-10 38.9 1.4 0.042 13.7 0.1 4.3 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA19551.1 - 8.6e-09 35.5 0.6 0.0028 17.6 0.0 3.3 4 0 0 4 4 3 2 RsgA GTPase AAA_23 PF13476.6 EEA19551.1 - 4.5e-08 33.8 1.1 0.0016 19.0 0.6 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EEA19551.1 - 3.9e-07 29.7 1.5 0.012 15.4 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA19551.1 - 6.9e-07 29.6 0.1 0.029 14.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 EEA19551.1 - 7.9e-07 29.6 0.0 0.014 15.8 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EEA19551.1 - 1e-06 28.8 0.5 0.01 15.5 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 EEA19551.1 - 1.2e-05 25.8 0.0 0.027 14.9 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EEA19551.1 - 5e-05 22.5 0.1 0.037 13.1 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein cobW PF02492.19 EEA19551.1 - 9e-05 22.1 0.8 0.2 11.2 0.4 2.8 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EEA19551.1 - 9.1e-05 22.5 0.2 0.12 12.4 0.0 3.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Dynamin_N PF00350.23 EEA19551.1 - 0.0001 22.4 0.0 0.0084 16.2 0.0 2.3 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EEA19551.1 - 0.00067 19.7 0.2 1.1 9.3 0.2 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EEA19551.1 - 0.00071 19.8 0.0 0.28 11.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EEA19551.1 - 0.00072 19.3 0.7 0.13 11.9 0.0 3.3 3 0 0 3 3 3 1 IstB-like ATP binding protein ATPase_2 PF01637.18 EEA19551.1 - 0.00086 19.3 0.2 0.5 10.2 0.2 2.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EEA19551.1 - 0.0012 18.8 0.1 2.4 8.1 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 EEA19551.1 - 0.0015 18.1 0.0 0.38 10.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EEA19551.1 - 0.0027 17.2 0.1 0.23 10.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 EEA19551.1 - 0.0031 17.7 0.0 1.5 9.0 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EEA19551.1 - 0.0038 16.4 4.3 0.2 10.8 0.6 3.3 2 2 0 2 2 2 1 NB-ARC domain AAA_11 PF13086.6 EEA19551.1 - 0.007 16.2 0.1 1.5 8.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EEA19551.1 - 0.017 14.9 0.2 1.7 8.4 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 EEA19551.1 - 0.018 14.8 0.2 8.6 6.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA19551.1 - 0.02 15.4 0.2 1.1 9.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EEA19551.1 - 0.023 15.1 0.1 1.7 9.1 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 EEA19551.1 - 0.025 14.6 0.0 21 5.1 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EEA19551.1 - 0.039 14.3 1.9 8.7 6.7 0.1 2.9 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EEA19551.1 - 0.04 13.3 0.8 1.2 8.5 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family TsaE PF02367.17 EEA19551.1 - 0.042 13.9 0.0 3.3 7.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 EEA19551.1 - 0.043 13.3 0.1 15 4.9 0.0 2.7 3 0 0 3 3 3 0 PhoH-like protein MobB PF03205.14 EEA19551.1 - 0.053 13.4 0.4 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.29 EEA19551.1 - 0.057 13.2 0.2 2.8 7.7 0.0 3.1 3 0 0 3 3 3 0 DEAD/DEAH box helicase SRPRB PF09439.10 EEA19551.1 - 0.075 12.5 0.0 8.1 5.8 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Mg_chelatase PF01078.21 EEA19551.1 - 0.097 12.0 0.1 2.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA12 PF10443.9 EEA19551.1 - 0.11 11.3 0.1 1.6 7.3 0.0 2.1 2 0 0 2 2 2 0 RNA12 protein GTP_EFTU PF00009.27 EEA19551.1 - 0.11 12.0 0.2 5.4 6.5 0.0 2.8 3 0 0 3 3 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EEA19551.1 - 0.11 12.1 0.3 0.75 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 EEA19551.1 - 0.12 11.2 1.0 1.3 7.7 0.1 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein DUF815 PF05673.13 EEA19551.1 - 0.12 11.5 0.1 0.56 9.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 EEA19551.1 - 0.21 11.8 0.3 3.2 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EEA19551.1 - 0.75 9.7 4.1 10 6.0 0.0 3.3 3 0 0 3 3 3 0 NTPase ABC_ATPase PF09818.9 EEA19551.1 - 0.97 8.2 2.6 7.3 5.3 0.4 2.9 4 0 0 4 4 4 0 Predicted ATPase of the ABC class DeoC PF01791.9 EEA19553.1 - 1.4e-17 64.1 4.3 2e-17 63.6 4.3 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase DHO_dh PF01180.21 EEA19553.1 - 4.2e-05 22.9 0.4 6.1e-05 22.4 0.4 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EEA19553.1 - 0.0011 18.5 1.0 0.0022 17.5 0.3 1.8 2 0 0 2 2 2 1 Histidine biosynthesis protein PcrB PF01884.17 EEA19553.1 - 0.04 13.4 0.5 0.085 12.3 0.5 1.6 1 1 0 1 1 1 0 PcrB family FMN_dh PF01070.18 EEA19553.1 - 0.042 12.9 1.0 0.085 11.9 1.0 1.4 1 0 0 1 1 1 0 FMN-dependent dehydrogenase SelK_SelG PF10961.8 EEA19554.1 - 0.058 14.0 0.0 0.092 13.4 0.0 1.5 1 0 0 1 1 1 0 Selenoprotein SelK_SelG WD40 PF00400.32 EEA19555.1 - 1.1e-07 32.4 2.2 0.00013 22.7 0.1 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19555.1 - 0.0033 17.7 0.0 3.3 8.1 0.0 3.3 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Gryzun-like PF12742.7 EEA19555.1 - 0.027 14.5 0.0 0.067 13.2 0.0 1.6 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking PQQ_3 PF13570.6 EEA19555.1 - 0.062 13.8 5.9 1.5 9.4 0.5 3.6 3 1 1 4 4 4 0 PQQ-like domain PQQ_2 PF13360.6 EEA19555.1 - 0.071 12.7 2.1 0.44 10.1 0.7 2.4 1 1 1 2 2 2 0 PQQ-like domain TMF_TATA_bd PF12325.8 EEA19555.1 - 0.43 10.8 6.2 0.73 10.1 6.2 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CENP-Q PF13094.6 EEA19555.1 - 1 9.6 7.6 1.7 8.8 7.6 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4407 PF14362.6 EEA19555.1 - 1.4 8.2 8.5 2.2 7.6 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LIAS_N PF16881.5 EEA19557.1 - 2.1e-23 82.8 0.0 4.3e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EEA19557.1 - 4e-15 56.6 0.0 6.2e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HAD PF12710.7 EEA19558.1 - 8.7e-26 91.5 0.0 1.2e-25 91.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA19558.1 - 3.5e-19 69.9 0.6 5.5e-19 69.3 0.6 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EEA19558.1 - 4e-10 39.9 0.0 1.2e-08 35.0 0.0 2.7 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA19558.1 - 5.3e-06 26.6 0.1 3.8e-05 23.9 0.1 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EEA19558.1 - 0.00035 20.0 0.0 0.0019 17.6 0.0 1.9 1 1 0 1 1 1 1 Putative Phosphatase DUF4392 PF14336.6 EEA19558.1 - 0.13 11.7 0.3 3.3 7.1 0.1 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4392) PAPS_reduct PF01507.19 EEA19559.1 - 1.6e-45 155.3 0.0 2.1e-44 151.6 0.0 2.0 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family FAD_binding_3 PF01494.19 EEA19560.1 - 3.8e-11 42.8 3.2 9.4e-10 38.3 3.2 2.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA19560.1 - 0.00035 20.3 0.2 0.004 16.8 0.1 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA19560.1 - 0.013 14.7 0.0 0.79 8.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA19560.1 - 0.033 14.4 0.0 0.092 13.0 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_2 PF03446.15 EEA19560.1 - 0.13 12.5 0.0 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase zf-Di19 PF05605.12 EEA19561.1 - 0.0015 18.8 3.3 0.07 13.4 0.3 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding Clusterin PF01093.17 EEA19561.1 - 0.0028 16.8 0.1 0.0045 16.1 0.1 1.4 1 0 0 1 1 1 1 Clusterin zf-H2C2_2 PF13465.6 EEA19561.1 - 0.048 14.1 4.9 1.6 9.3 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger double domain PMC2NT PF08066.12 EEA19561.1 - 0.2 12.4 1.5 0.63 10.8 1.5 1.8 1 0 0 1 1 1 0 PMC2NT (NUC016) domain MFS_1 PF07690.16 EEA19563.1 - 7.8e-19 67.8 61.7 9e-16 57.7 37.8 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19563.1 - 0.0041 16.0 24.0 0.065 12.1 3.3 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter ATP-sulfurylase PF01747.17 EEA19565.1 - 1.3e-86 289.5 0.1 1.9e-86 288.9 0.1 1.3 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EEA19565.1 - 6.7e-60 201.5 0.1 1e-59 200.9 0.1 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EEA19565.1 - 5.8e-51 172.3 0.0 9.9e-51 171.6 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_18 PF13238.6 EEA19565.1 - 0.11 13.1 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Methyltransf_11 PF08241.12 EEA19566.1 - 3.3e-15 56.5 0.0 7.8e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19566.1 - 8.2e-12 45.7 0.0 2.5e-11 44.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19566.1 - 1.6e-07 31.2 0.0 3.2e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA19566.1 - 6.7e-07 29.3 0.0 1.1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA19566.1 - 8.9e-07 29.6 0.0 3.2e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA19566.1 - 3.8e-05 23.1 0.0 6.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Acetyltransf_1 PF00583.25 EEA19567.1 - 3.7e-08 33.6 0.0 7.3e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA19567.1 - 4.9e-06 26.5 0.0 9.3e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA19567.1 - 8.8e-05 22.9 0.0 0.00035 20.9 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EEA19567.1 - 0.011 16.4 0.6 0.26 11.9 0.0 2.4 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA19567.1 - 0.048 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Sugar_tr PF00083.24 EEA19568.1 - 8.9e-130 433.5 29.9 1e-129 433.3 29.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19568.1 - 2.7e-22 79.2 43.2 1.2e-14 54.0 18.3 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA19568.1 - 0.00032 19.4 26.4 0.0013 17.4 0.2 3.5 3 1 1 4 4 4 2 MFS/sugar transport protein Pox_A14 PF05767.12 EEA19568.1 - 0.003 17.7 3.7 0.019 15.1 0.2 2.8 2 0 0 2 2 2 1 Poxvirus virion envelope protein A14 O_anti_polymase PF01901.16 EEA19568.1 - 0.64 9.2 11.5 0.068 12.4 3.5 2.5 2 1 0 2 2 2 0 Putative O-antigen polymerase DUF4293 PF14126.6 EEA19568.1 - 2.2 8.5 8.2 5.2 7.3 1.9 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) EGF PF00008.27 EEA19569.1 - 0.32 11.4 5.2 0.58 10.5 5.2 1.5 1 0 0 1 1 1 0 EGF-like domain Adaptin_binding PF10199.9 EEA19570.1 - 0.069 13.8 5.0 0.14 12.8 1.7 2.6 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF4637 PF15470.6 EEA19570.1 - 0.2 11.3 3.1 0.44 10.3 3.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4637) Complex1_LYR PF05347.15 EEA19571.1 - 3.6e-18 65.4 5.0 3.6e-18 65.4 5.0 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EEA19571.1 - 8e-06 26.5 2.8 9.6e-06 26.3 2.8 1.1 1 0 0 1 1 1 1 Complex1_LYR-like NA37 PF04245.13 EEA19571.1 - 0.005 16.4 0.1 0.0052 16.3 0.1 1.1 1 0 0 1 1 1 1 37-kD nucleoid-associated bacterial protein Mg_trans_NIPA PF05653.14 EEA19573.1 - 2e-91 306.1 12.9 2.6e-91 305.8 12.9 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EEA19573.1 - 0.0059 16.8 5.2 0.0059 16.8 5.2 3.8 3 1 0 3 3 3 2 EamA-like transporter family SET PF00856.28 EEA19574.1 - 1.3e-13 51.7 0.3 1.3e-13 51.7 0.3 3.7 3 2 0 3 3 3 1 SET domain AWS PF17907.1 EEA19574.1 - 2.4e-08 33.9 7.9 2.4e-08 33.9 7.9 1.9 2 0 0 2 2 2 1 AWS domain DHHC PF01529.20 EEA19575.1 - 2.7e-34 118.1 5.7 2.7e-34 118.1 5.7 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Yip1 PF04893.17 EEA19575.1 - 0.0069 16.1 0.9 0.0069 16.1 0.9 2.1 2 0 0 2 2 2 1 Yip1 domain Pkinase PF00069.25 EEA19576.1 - 1e-12 48.0 0.0 2e-10 40.5 0.0 2.4 3 0 0 3 3 3 2 Protein kinase domain APH PF01636.23 EEA19576.1 - 0.00077 19.5 0.4 0.0036 17.3 0.3 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EEA19576.1 - 0.07 12.4 0.0 0.25 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein tyrosine kinase RHH_5 PF07878.11 EEA19577.1 - 0.083 12.8 0.2 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 PMT PF02366.18 EEA19578.1 - 4.7e-78 262.2 18.0 8.8e-78 261.3 18.0 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EEA19578.1 - 1.7e-67 226.9 9.4 1.7e-67 226.9 9.4 2.2 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EEA19578.1 - 2.1e-48 164.7 0.1 5e-48 163.4 0.1 1.6 1 0 0 1 1 1 1 MIR domain PRP21_like_P PF12230.8 EEA19579.1 - 1e-57 195.5 12.6 2.4e-57 194.3 12.6 1.6 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EEA19579.1 - 9.8e-39 131.1 1.5 1.7e-19 69.5 0.0 2.5 2 0 0 2 2 2 2 Surp module zf_UBZ PF18439.1 EEA19579.1 - 0.0045 16.5 0.2 0.01 15.4 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger E7 PF00527.18 EEA19579.1 - 7.1 6.9 10.2 10 6.4 2.5 2.8 2 1 0 2 2 2 0 E7 protein, Early protein Sec2p PF06428.11 EEA19580.1 - 2.4e-28 97.9 19.9 2.4e-28 97.9 19.9 2.5 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Macoilin PF09726.9 EEA19580.1 - 3.4e-05 22.6 16.7 3.4e-05 22.6 16.7 2.0 2 0 0 2 2 2 1 Macoilin family DUF4276 PF14103.6 EEA19580.1 - 0.014 15.6 1.0 0.045 14.0 1.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4276) CorA PF01544.18 EEA19580.1 - 1.3 8.2 8.1 2.5 7.3 8.1 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Fib_alpha PF08702.10 EEA19580.1 - 3.6 7.8 23.0 0.13 12.4 5.7 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Med9 PF07544.13 EEA19580.1 - 9.3 6.4 13.5 28 4.9 6.7 3.3 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 dsDNA_bind PF01984.20 EEA19581.1 - 1.7e-38 131.3 10.7 2e-38 131.1 10.7 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF4615 PF15393.6 EEA19581.1 - 0.0076 16.8 0.5 0.01 16.4 0.4 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4615) Coq4 PF05019.13 EEA19582.1 - 4.7e-96 320.4 0.0 5.6e-96 320.1 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF2236 PF09995.9 EEA19582.1 - 0.073 13.3 0.2 0.12 12.5 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2236) TrkH PF02386.16 EEA19583.1 - 9.4e-103 344.3 5.1 6.3e-98 328.4 1.6 2.0 2 0 0 2 2 2 2 Cation transport protein DUF4538 PF15061.6 EEA19583.1 - 0.11 12.2 1.2 2.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Oxidored_FMN PF00724.20 EEA19584.1 - 1.3e-96 323.8 0.0 1.8e-96 323.4 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family SET PF00856.28 EEA19585.1 - 7.4e-23 81.8 0.0 1.3e-22 81.0 0.0 1.4 1 0 0 1 1 1 1 SET domain SWIRM-assoc_1 PF16495.5 EEA19585.1 - 0.16 12.0 0.9 0.35 10.9 0.9 1.5 1 0 0 1 1 1 0 SWIRM-associated region 1 FlgN PF05130.12 EEA19585.1 - 0.33 11.5 3.0 0.39 11.2 0.7 2.0 2 0 0 2 2 2 0 FlgN protein ApbA_C PF08546.11 EEA19586.1 - 1.1e-33 116.1 0.8 1.7e-33 115.5 0.8 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EEA19586.1 - 1.4e-28 99.5 0.0 9.1e-27 93.6 0.0 2.3 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 EEA19586.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 ThiF family V_ATPase_prox PF18274.1 EEA19586.1 - 0.15 12.0 0.2 0.67 10.0 0.1 2.1 2 0 0 2 2 2 0 Vacuolar ATPase Subunit I N-terminal proximal lobe Tnp_P_element_C PF12596.8 EEA19586.1 - 0.29 11.7 1.4 9.7 6.8 0.0 2.3 2 0 0 2 2 2 0 87kDa Transposase Sas10_Utp3 PF04000.15 EEA19587.1 - 3.1e-17 63.0 1.5 3.1e-17 63.0 1.5 2.9 3 0 0 3 3 3 1 Sas10/Utp3/C1D family Nop53 PF07767.11 EEA19587.1 - 0.2 11.0 36.5 0.29 10.5 36.5 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) LAP1C PF05609.12 EEA19587.1 - 1.5 7.8 20.3 1.7 7.6 20.3 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF5619 PF18505.1 EEA19587.1 - 5 7.2 6.4 1.3 9.1 0.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5619) DUF2076 PF09849.9 EEA19588.1 - 5.9e-08 33.1 10.5 7.4e-08 32.8 10.5 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EEA19588.1 - 2.7e-05 24.2 2.2 4.1e-05 23.6 2.2 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EEA19588.1 - 0.019 14.9 0.5 0.031 14.3 0.5 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UBX PF00789.20 EEA19589.1 - 2.2e-11 43.8 0.0 4.5e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 UBX domain Vfa1 PF08432.10 EEA19589.1 - 0.15 12.4 12.4 0.33 11.3 12.4 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TFIIA PF03153.13 EEA19589.1 - 0.91 9.5 22.4 0.02 14.9 16.0 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 EEA19589.1 - 4.4 7.1 12.0 7.7 6.3 12.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tho2 PF11262.8 EEA19589.1 - 8.7 5.4 10.2 14 4.7 10.2 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 UBX PF00789.20 EEA19590.1 - 1.6e-11 44.3 0.0 3.2e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 UBX domain Vfa1 PF08432.10 EEA19590.1 - 0.07 13.5 11.9 0.15 12.3 11.9 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PA26 PF04636.13 EEA19590.1 - 6.3 5.6 7.9 9.1 5.1 7.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Tho2 PF11262.8 EEA19590.1 - 7.1 5.7 10.2 11 5.2 10.2 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 LMBR1 PF04791.16 EEA19590.1 - 8.1 5.2 4.6 10 4.9 4.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SURF1 PF02104.15 EEA19591.1 - 7.2e-46 156.6 0.0 1.3e-45 155.8 0.0 1.3 1 0 0 1 1 1 1 SURF1 family CENP-T_C PF15511.6 EEA19592.1 - 1.2e-45 154.1 0.0 1.8e-45 153.5 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EEA19592.1 - 2.5e-08 34.2 0.1 4.5e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EEA19592.1 - 0.0001 22.6 0.7 0.00028 21.2 0.1 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA19592.1 - 0.052 13.8 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF531 PF04407.12 EEA19592.1 - 0.21 11.7 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF531) Homeobox_KN PF05920.11 EEA19592.1 - 0.36 10.8 2.3 5.1 7.1 0.0 3.1 2 1 1 3 3 3 0 Homeobox KN domain CMS1 PF14617.6 EEA19593.1 - 8.7e-74 248.0 9.9 1.1e-73 247.7 9.9 1.1 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EEA19593.1 - 2.5e-06 27.4 0.0 4e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase NAD_Gly3P_dh_C PF07479.14 EEA19593.1 - 0.071 13.4 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus CMS1 PF14617.6 EEA19594.1 - 4.3e-69 232.7 13.5 8.6e-56 189.1 9.3 2.1 1 1 1 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EEA19594.1 - 0.00095 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Vps54 PF07928.12 EEA19594.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 Vps54-like protein NAD_Gly3P_dh_C PF07479.14 EEA19594.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus Methyltransf_23 PF13489.6 EEA19595.1 - 1.6e-20 73.6 0.0 2.5e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA19595.1 - 1.2e-10 41.9 0.0 7.7e-09 36.2 0.0 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19595.1 - 1.3e-10 41.8 0.0 3.7e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19595.1 - 7.2e-10 38.9 0.0 7.5e-09 35.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19595.1 - 3.6e-07 30.8 0.0 8.5e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA19595.1 - 0.00085 18.9 0.0 0.0098 15.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain UPF0146 PF03686.13 EEA19595.1 - 0.0079 16.1 0.0 1.8 8.5 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0146) Methyltransf_16 PF10294.9 EEA19595.1 - 0.0089 15.8 0.0 0.036 13.8 0.0 1.8 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_4 PF02390.17 EEA19595.1 - 0.042 13.3 0.6 0.12 11.8 0.0 2.1 3 0 0 3 3 3 0 Putative methyltransferase PrmA PF06325.13 EEA19595.1 - 0.097 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EEA19596.1 - 1.5e-20 73.6 0.0 2.4e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA19596.1 - 1.2e-10 42.0 0.0 7.5e-09 36.2 0.0 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19596.1 - 1.3e-10 41.8 0.0 3.7e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19596.1 - 6.9e-10 38.9 0.0 7.4e-09 35.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19596.1 - 3.5e-07 30.8 0.0 8.3e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA19596.1 - 0.00083 18.9 0.0 0.0096 15.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain UPF0146 PF03686.13 EEA19596.1 - 0.0076 16.1 0.0 1.7 8.5 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0146) Methyltransf_16 PF10294.9 EEA19596.1 - 0.0086 15.8 0.0 0.036 13.8 0.0 1.8 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_4 PF02390.17 EEA19596.1 - 0.042 13.3 0.6 0.12 11.8 0.0 2.1 3 0 0 3 3 3 0 Putative methyltransferase PrmA PF06325.13 EEA19596.1 - 0.096 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RRM_1 PF00076.22 EEA19597.1 - 2.7e-14 52.8 0.0 7.3e-14 51.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA19597.1 - 0.039 14.1 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif Ras PF00071.22 EEA19598.1 - 2.6e-54 183.2 0.0 3e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA19598.1 - 2.6e-20 72.8 0.0 3.7e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA19598.1 - 1.6e-07 30.9 0.0 2.1e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Zn_clus PF00172.18 EEA19599.1 - 9.1e-07 28.9 10.7 9.1e-07 28.9 10.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA19599.1 - 2.6e-05 23.4 0.1 6.2e-05 22.2 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Rabaptin PF03528.15 EEA19599.1 - 0.32 9.6 0.7 0.48 9.1 0.7 1.1 1 0 0 1 1 1 0 Rabaptin RhoGAP PF00620.27 EEA19600.1 - 1.4e-50 171.1 0.0 5.6e-50 169.1 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EEA19600.1 - 4e-14 52.6 0.6 4e-14 52.6 0.6 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF3135 PF11333.8 EEA19600.1 - 0.13 12.6 0.2 17 5.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) GIDA_assoc PF13932.6 EEA19600.1 - 2.1 8.5 9.4 3.9 7.6 9.3 1.5 1 1 0 1 1 1 0 GidA associated domain DUF4472 PF14739.6 EEA19600.1 - 5 7.9 9.5 0.33 11.7 2.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF1348 PF07080.11 EEA19601.1 - 0.043 13.7 0.4 0.077 12.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1348) HTH_32 PF13565.6 EEA19602.1 - 1.2e-07 32.2 7.0 0.0001 22.8 0.5 2.3 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 EEA19602.1 - 0.0002 21.5 0.3 0.0019 18.4 0.0 2.5 2 0 0 2 2 2 1 Transposase MFS_1 PF07690.16 EEA19603.1 - 1.7e-52 178.5 45.6 8e-41 140.1 24.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA19603.1 - 7.7e-08 31.3 25.1 8.3e-07 27.9 5.8 2.6 3 0 0 3 3 3 2 MFS/sugar transport protein OATP PF03137.20 EEA19603.1 - 2.6e-06 26.0 7.4 4.2e-05 22.0 6.9 2.3 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EEA19603.1 - 4.6e-06 25.3 14.3 0.0032 15.9 1.2 2.5 2 1 0 2 2 2 2 Transmembrane secretion effector Sugar_tr PF00083.24 EEA19603.1 - 9.4e-05 21.4 11.4 9.4e-05 21.4 11.4 2.4 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 EEA19603.1 - 0.00022 20.2 9.8 0.00022 20.2 9.8 3.1 1 1 1 2 2 2 1 MFS_1 like family MBA1 PF07961.11 EEA19604.1 - 0.011 14.8 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 MBA1-like protein EOS1 PF12326.8 EEA19605.1 - 1.6e-13 51.0 9.2 1.6e-13 51.0 9.2 2.4 2 1 1 3 3 3 1 N-glycosylation protein SOG2 PF10428.9 EEA19605.1 - 0.23 10.6 9.4 0.34 10.1 9.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Pneumo_att_G PF05539.11 EEA19605.1 - 3.6 7.1 19.4 6.7 6.2 19.4 1.5 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SUI1 PF01253.22 EEA19606.1 - 3.5e-28 97.9 3.6 4.7e-28 97.5 3.6 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 GlcNAc-1_reg PF18440.1 EEA19606.1 - 0.097 12.9 0.5 0.15 12.3 0.5 1.3 1 0 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain SUI1 PF01253.22 EEA19607.1 - 3.1e-28 98.1 3.6 4.1e-28 97.7 3.6 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 GlcNAc-1_reg PF18440.1 EEA19607.1 - 0.081 13.2 0.4 0.13 12.5 0.4 1.3 1 0 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain AWS PF17907.1 EEA19608.1 - 0.12 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 AWS domain p450 PF00067.22 EEA19609.1 - 7.4e-53 179.9 0.0 1.8e-51 175.3 0.0 2.6 1 1 0 1 1 1 1 Cytochrome P450 Med12 PF09497.10 EEA19609.1 - 3.1e-27 94.6 0.0 8.1e-27 93.3 0.0 1.8 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 EEA19609.1 - 0.0012 17.8 0.0 0.0028 16.6 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic Mediator 12 subunit domain Glyco_hydro_71 PF03659.14 EEA19610.1 - 1.9e-131 438.4 8.2 2.1e-131 438.2 8.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 ThiG PF05690.14 EEA19610.1 - 0.015 14.7 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Abhydrolase_6 PF12697.7 EEA19611.1 - 1.7e-10 41.9 0.0 2.3e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19611.1 - 1.5e-05 24.4 0.0 2.1e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA19611.1 - 0.012 15.3 0.0 0.032 13.9 0.0 1.8 2 1 0 2 2 2 0 alpha/beta hydrolase fold DUF2920 PF11144.8 EEA19611.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Glyco_hydro_18 PF00704.28 EEA19613.1 - 2.4e-15 57.1 0.3 3.1e-15 56.7 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 HNH_2 PF13391.6 EEA19615.1 - 4.7e-10 39.4 0.0 8.8e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease HNH_2 PF13391.6 EEA19616.1 - 7.2e-14 51.7 0.0 1.5e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease adh_short PF00106.25 EEA19617.1 - 9.5e-21 74.1 0.2 4.7e-17 62.1 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19617.1 - 1.4e-10 41.1 0.0 2.3e-08 33.9 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19617.1 - 0.0014 18.5 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 KR domain ATP-synt_ab PF00006.25 EEA19617.1 - 0.03 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF3425 PF11905.8 EEA19618.1 - 5.6e-17 61.9 0.0 1e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DUF3632 PF12311.8 EEA19619.1 - 0.0011 19.4 0.9 0.0011 19.4 0.9 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3632) RRM_1 PF00076.22 EEA19620.1 - 0.022 14.6 0.0 0.053 13.3 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PhyH PF05721.13 EEA19621.1 - 6.4e-08 33.1 0.1 1.6e-07 31.8 0.1 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PhyH PF05721.13 EEA19622.1 - 6.4e-08 33.1 0.1 1.6e-07 31.8 0.1 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) CIA30 PF08547.12 EEA19624.1 - 1.4e-39 135.6 0.0 5.7e-26 91.4 0.0 2.1 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) Cation_ATPase_N PF00690.26 EEA19624.1 - 0.085 12.6 0.0 0.25 11.0 0.0 1.8 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus ANAPC5 PF12862.7 EEA19625.1 - 1.9e-35 120.8 3.4 1.9e-35 120.8 3.4 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_10 PF13374.6 EEA19625.1 - 4.1e-06 26.5 0.2 0.00073 19.3 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA19625.1 - 0.00023 21.4 7.6 0.039 14.2 0.1 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA19625.1 - 0.00033 21.1 0.2 1.3 9.6 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA19625.1 - 0.0018 18.3 0.3 0.23 11.8 0.2 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA19625.1 - 0.02 14.9 0.1 1.8 8.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA19625.1 - 0.025 15.2 0.2 0.25 12.0 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA19625.1 - 0.028 14.5 0.1 0.19 11.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat SAICAR_synt PF01259.18 EEA19626.1 - 6e-98 327.5 0.0 7.1e-98 327.2 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase polyprenyl_synt PF00348.17 EEA19627.1 - 8.1e-72 241.4 0.0 2.4e-71 239.8 0.0 1.7 1 1 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EEA19627.1 - 0.0026 17.4 0.0 0.0042 16.7 0.0 1.2 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Rpn3_C PF08375.11 EEA19628.1 - 5.2e-25 87.6 0.9 5.2e-25 87.6 0.9 2.1 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EEA19628.1 - 9.8e-19 67.8 0.1 8e-18 64.9 0.0 2.5 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 EEA19628.1 - 0.04 14.0 0.0 0.15 12.3 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 EEA19628.1 - 0.064 13.2 0.2 0.76 9.8 0.1 2.6 2 1 0 2 2 2 0 CSN8/PSMD8/EIF3K family Macoilin PF09726.9 EEA19628.1 - 6 5.3 6.3 9.4 4.6 6.3 1.3 1 0 0 1 1 1 0 Macoilin family DASH_Spc34 PF08657.10 EEA19629.1 - 9.5e-43 146.8 9.8 1.1e-22 81.0 0.2 2.0 1 1 1 2 2 2 2 DASH complex subunit Spc34 DUF724 PF05266.14 EEA19629.1 - 0.018 14.9 0.3 0.035 13.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PRKG1_interact PF15898.5 EEA19629.1 - 0.35 11.8 6.6 0.089 13.7 2.7 1.9 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DASH_Spc19 PF08287.11 EEA19629.1 - 1.2 9.1 7.6 0.13 12.2 3.1 1.6 2 0 0 2 2 2 0 Spc19 TFIID_20kDa PF03847.13 EEA19630.1 - 5.3e-21 74.9 0.0 8.4e-21 74.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A MDM10 PF12519.8 EEA19630.1 - 1.4 7.7 18.5 3.9 6.2 18.5 1.7 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CorA PF01544.18 EEA19631.1 - 7.3e-13 48.5 0.1 1.3e-12 47.7 0.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein eIF2A PF08662.11 EEA19632.1 - 6.8e-81 270.8 0.0 5e-80 268.0 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EEA19632.1 - 0.00074 20.3 0.6 0.12 13.3 0.1 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19632.1 - 0.021 15.1 0.0 29 5.0 0.0 4.7 4 2 2 6 6 6 0 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EEA19632.1 - 0.025 13.1 0.0 0.048 12.2 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain PD40 PF07676.12 EEA19632.1 - 0.08 12.9 0.6 42 4.2 0.1 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat IKI3 PF04762.12 EEA19632.1 - 0.096 10.7 0.0 0.18 9.8 0.0 1.3 1 0 0 1 1 1 0 IKI3 family Acetyltransf_13 PF13880.6 EEA19635.1 - 1.6e-26 92.0 0.0 3e-25 88.0 0.0 2.4 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EEA19635.1 - 3.9e-13 49.0 0.1 8.1e-13 48.0 0.1 1.6 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO EMG1 PF03587.14 EEA19636.1 - 5.3e-80 267.7 0.0 6.2e-80 267.4 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase RP854 PF17460.2 EEA19636.1 - 0.057 13.2 0.0 0.12 12.2 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized protein RP854 EMG1 PF03587.14 EEA19637.1 - 4.4e-80 267.9 0.0 5e-80 267.7 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase RP854 PF17460.2 EEA19637.1 - 0.049 13.4 0.0 0.1 12.4 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized protein RP854 Glyoxalase PF00903.25 EEA19638.1 - 0.01 16.0 0.8 0.028 14.6 0.0 2.2 3 0 0 3 3 3 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Gly-zipper_Omp PF13488.6 EEA19638.1 - 0.024 14.6 0.3 0.056 13.5 0.3 1.6 1 0 0 1 1 1 0 Glycine zipper Rick_17kDa_Anti PF05433.15 EEA19638.1 - 0.16 11.9 2.1 0.41 10.5 2.1 1.7 1 0 0 1 1 1 0 Glycine zipper 2TM domain UQ_con PF00179.26 EEA19639.1 - 7.4e-52 174.7 0.0 8.3e-52 174.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA19639.1 - 0.049 13.9 0.0 0.059 13.7 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EEA19639.1 - 0.059 13.2 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 EEA19639.1 - 0.076 12.7 0.0 0.095 12.4 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic E2 family B UQ_con PF00179.26 EEA19640.1 - 1.1e-42 145.0 0.0 1.3e-42 144.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EEA19640.1 - 0.03 14.2 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EEA19640.1 - 0.032 14.5 0.0 0.043 14.1 0.0 1.2 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EEA19640.1 - 0.059 13.1 0.0 0.072 12.8 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic E2 family B UQ_con PF00179.26 EEA19641.1 - 1.1e-42 145.0 0.0 1.3e-42 144.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EEA19641.1 - 0.03 14.2 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EEA19641.1 - 0.032 14.5 0.0 0.043 14.1 0.0 1.2 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EEA19641.1 - 0.059 13.1 0.0 0.072 12.8 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic E2 family B Acyl-CoA_dh_N PF02771.16 EEA19642.1 - 5.4e-27 94.7 0.2 1e-26 93.8 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EEA19642.1 - 2e-24 86.5 0.3 2e-24 86.5 0.3 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EEA19642.1 - 6.8e-16 58.3 0.0 1.2e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA19642.1 - 3.6e-07 30.5 0.4 3.6e-07 30.5 0.4 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_1 PF00441.24 EEA19643.1 - 9.1e-25 87.6 0.3 1.2e-24 87.2 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA19643.1 - 2.5e-16 60.4 0.2 4.5e-16 59.5 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA19643.1 - 4.6e-16 58.8 0.0 8.2e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA19643.1 - 1.6e-07 31.7 0.4 2.3e-07 31.1 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_1 PF00441.24 EEA19644.1 - 9.1e-25 87.6 0.3 1.2e-24 87.2 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA19644.1 - 2.5e-16 60.4 0.2 4.5e-16 59.5 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA19644.1 - 4.6e-16 58.8 0.0 8.2e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA19644.1 - 1.6e-07 31.7 0.4 2.3e-07 31.1 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain NAD_binding_6 PF08030.12 EEA19645.1 - 1.9e-33 115.8 0.0 2.9e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EEA19645.1 - 4e-21 75.1 0.0 1.1e-20 73.8 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EEA19645.1 - 1.4e-19 70.4 10.6 1.4e-19 70.4 10.6 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 EEA19645.1 - 0.07 13.8 0.0 0.3 11.7 0.0 2.1 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Zn_clus PF00172.18 EEA19646.1 - 1.8e-09 37.6 11.3 3.6e-09 36.6 11.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA19646.1 - 2.8e-09 36.4 0.5 4.6e-09 35.7 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain GGDEF_2 PF17853.1 EEA19646.1 - 0.0097 16.2 0.1 0.019 15.2 0.1 1.4 1 0 0 1 1 1 1 GGDEF-like domain Alpha-amylase PF00128.24 EEA19647.1 - 1.6e-116 389.6 0.3 6.7e-116 387.5 0.2 1.8 1 1 1 2 2 2 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EEA19647.1 - 0.0078 16.3 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 EEA19647.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Sugar_tr PF00083.24 EEA19648.1 - 9.8e-89 298.3 24.3 1.1e-88 298.1 24.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19648.1 - 5.4e-21 74.9 46.9 2.6e-19 69.4 26.0 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA19648.1 - 0.00049 18.8 23.6 0.0015 17.1 2.7 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 EEA19648.1 - 0.0019 17.1 10.9 0.014 14.3 3.6 2.2 2 0 0 2 2 2 2 MFS_1 like family OppC_N PF12911.7 EEA19648.1 - 1.6 8.8 8.2 0.86 9.6 0.6 2.9 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C YtpI PF14007.6 EEA19648.1 - 4.5 7.5 8.8 0.94 9.7 3.0 2.5 2 0 0 2 2 2 0 YtpI-like protein DUF4131 PF13567.6 EEA19648.1 - 7.4 6.2 13.8 0.29 10.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Glyco_hydro_49N PF17433.2 EEA19649.1 - 9.9e-88 292.7 0.6 9.9e-88 292.7 0.6 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 49 N-terminal Ig-like domain Glyco_hydro_49 PF03718.13 EEA19649.1 - 1.2e-40 138.1 0.6 2.6e-40 137.1 0.6 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 49 B_solenoid_dext PF18841.1 EEA19649.1 - 2.2e-17 63.1 5.2 6e-17 61.6 5.2 1.9 1 0 0 1 1 1 1 Beta solenoid repeat from Dextranase IPU_b_solenoid PF18783.1 EEA19649.1 - 1e-13 51.1 0.6 1e-13 51.1 0.6 1.8 2 0 0 2 2 2 1 Isopullulanase beta-solenoid repeat DUF3446 PF11928.8 EEA19650.1 - 0.0025 18.1 7.4 0.0025 18.1 7.4 2.5 3 0 0 3 3 3 1 Early growth response N-terminal domain FAM220 PF15487.6 EEA19650.1 - 1.2 8.7 10.2 0.093 12.3 5.6 1.4 2 0 0 2 2 2 0 FAM220 family Chorion_2 PF03964.15 EEA19650.1 - 1.3 9.9 6.8 7.5 7.4 4.2 2.4 2 0 0 2 2 2 0 Chorion family 2 Zn_clus PF00172.18 EEA19651.1 - 2.4e-08 34.0 7.9 3.9e-08 33.3 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA19651.1 - 3.5e-05 23.0 0.2 9.1e-05 21.6 0.2 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Apc15p PF05841.11 EEA19651.1 - 1 10.2 7.5 0.16 12.8 1.3 2.5 2 0 0 2 2 2 0 Apc15p protein XPG_I PF00867.18 EEA19652.1 - 3e-31 107.6 1.2 1.4e-30 105.5 0.1 2.3 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EEA19652.1 - 2.8e-21 75.9 0.1 1.8e-20 73.3 0.0 2.3 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EEA19652.1 - 3.7e-06 27.5 0.5 1.8e-05 25.2 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EEA19652.1 - 0.04 14.5 0.0 0.11 13.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_2 PF12826.7 EEA19652.1 - 0.09 12.9 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif Linker_histone PF00538.19 EEA19653.1 - 5.9e-30 103.5 0.2 5.9e-30 103.5 0.2 1.9 3 0 0 3 3 3 1 linker histone H1 and H5 family PIP5K PF01504.18 EEA19654.1 - 7e-101 337.0 0.0 1.4e-100 336.1 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase SKG6 PF08693.10 EEA19655.1 - 2.5e-07 30.0 0.4 5.2e-07 29.0 0.4 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 EEA19655.1 - 0.025 14.5 0.1 0.025 14.5 0.1 2.5 2 2 1 3 3 3 0 TMEM154 protein family Granulin PF00396.18 EEA19655.1 - 0.085 13.2 2.0 0.58 10.5 0.2 2.4 2 0 0 2 2 2 0 Granulin LcrG PF07216.12 EEA19655.1 - 0.12 12.3 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 LcrG protein UBA2_C PF16195.5 EEA19656.1 - 0.016 15.9 0.7 0.046 14.4 0.7 1.7 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus ANAPC1 PF12859.7 EEA19657.1 - 5.4e-31 107.8 0.6 5.4e-31 107.8 0.6 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EEA19657.1 - 0.02 15.3 9.1 0.96 10.0 0.0 4.7 4 0 0 4 4 4 0 Proteasome/cyclosome repeat tRNA-synt_1b PF00579.25 EEA19658.1 - 4.5e-54 183.8 0.0 5.6e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) IMPa_helical PF18642.1 EEA19658.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 Immunomodulating metalloprotease helical domain Epimerase PF01370.21 EEA19658.1 - 0.16 11.4 0.0 0.53 9.7 0.0 1.8 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family Fungal_trans_2 PF11951.8 EEA19659.1 - 1.1e-41 142.9 3.9 2.1e-40 138.7 3.9 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19659.1 - 2.9e-06 27.3 9.8 2.9e-06 27.3 9.8 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TAF4 PF05236.14 EEA19659.1 - 0.079 12.7 0.1 0.079 12.7 0.1 2.1 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Spc7_N PF15402.6 EEA19659.1 - 0.28 9.4 8.8 0.41 8.8 8.8 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 CCDC24 PF15669.5 EEA19659.1 - 0.87 9.4 6.5 0.22 11.4 3.2 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Suf PF05843.14 EEA19659.1 - 1.5 8.7 3.5 0.32 10.9 0.3 1.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Fungal_trans PF04082.18 EEA19661.1 - 3.8e-16 58.9 0.1 7e-16 58.1 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain EAP30 PF04157.16 EEA19661.1 - 0.091 12.0 0.2 0.62 9.3 0.1 2.1 2 0 0 2 2 2 0 EAP30/Vps36 family Telomere_reg-2 PF10193.9 EEA19661.1 - 0.12 12.8 0.4 6.5 7.2 0.0 2.6 2 0 0 2 2 2 0 Telomere length regulation protein Pap_E4 PF02711.14 EEA19661.1 - 0.28 12.2 3.2 8.4 7.4 3.0 2.5 2 0 0 2 2 2 0 E4 protein adh_short PF00106.25 EEA19662.1 - 2e-32 112.3 2.8 2.7e-32 111.8 2.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19662.1 - 1.6e-22 80.2 2.6 6.8e-22 78.2 2.6 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19662.1 - 2.7e-13 50.2 0.5 3.7e-13 49.8 0.5 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA19662.1 - 0.013 15.0 0.5 0.098 12.1 0.5 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA19662.1 - 0.051 12.7 0.1 0.063 12.4 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1414 PF07208.11 EEA19662.1 - 0.066 13.2 0.3 0.13 12.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1414) Ldh_1_N PF00056.23 EEA19662.1 - 0.12 12.5 0.6 0.19 11.8 0.6 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EEA19662.1 - 0.13 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase MFS_1 PF07690.16 EEA19663.1 - 7e-26 91.0 29.6 7e-26 91.0 29.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily ESSS PF10183.9 EEA19663.1 - 0.034 14.3 0.1 0.089 13.0 0.1 1.7 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) HGTP_anticodon PF03129.20 EEA19664.1 - 3.2e-22 78.5 0.7 9e-22 77.0 0.0 2.2 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EEA19664.1 - 2.6e-07 30.8 0.0 6.7e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) RPAP1_C PF08620.10 EEA19665.1 - 4.5e-25 87.6 0.0 7.5e-25 86.8 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EEA19665.1 - 3e-18 65.3 9.9 5.4e-18 64.5 9.9 1.4 1 0 0 1 1 1 1 RPAP1-like, N-terminal DUF4085 PF13315.6 EEA19665.1 - 0.21 11.2 1.3 0.36 10.4 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) HUN PF08729.10 EEA19666.1 - 3.3e-08 33.4 0.2 9.1e-08 32.0 0.2 1.8 1 0 0 1 1 1 1 HPC2 and ubinuclein domain IFRD PF05004.13 EEA19667.1 - 5.8e-86 288.4 5.4 7.8e-86 287.9 5.4 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Cnd3 PF12719.7 EEA19667.1 - 6e-05 22.4 0.5 0.00017 20.9 0.2 1.8 1 1 1 2 2 2 1 Nuclear condensing complex subunits, C-term domain DUF4698 PF15769.5 EEA19667.1 - 0.1 11.6 3.3 0.063 12.3 1.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4698) Transp_cyt_pur PF02133.15 EEA19668.1 - 1.7e-07 30.4 1.6 1.8e-07 30.3 1.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin CHD5 PF04420.14 EEA19668.1 - 0.033 14.0 0.3 0.035 14.0 0.3 1.1 1 0 0 1 1 1 0 CHD5-like protein Ail_Lom PF06316.11 EEA19668.1 - 0.12 12.1 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Enterobacterial Ail/Lom protein DUF1029 PF06269.12 EEA19668.1 - 0.33 11.1 3.5 1.5 9.0 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1029) Transp_cyt_pur PF02133.15 EEA19669.1 - 1.8e-12 46.8 0.2 2e-12 46.6 0.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Oxysterol_BP PF01237.18 EEA19670.1 - 1.8e-115 385.8 0.0 3.9e-115 384.6 0.0 1.6 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EEA19670.1 - 2.3e-38 130.4 0.2 4.7e-38 129.4 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EEA19670.1 - 1.9e-06 28.3 0.0 4.6e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EEA19670.1 - 0.021 15.2 0.4 0.45 11.0 0.4 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain zf-BED PF02892.15 EEA19671.1 - 0.94 9.5 7.5 5.9 7.0 1.8 2.7 2 0 0 2 2 2 0 BED zinc finger HeLo PF14479.6 EEA19671.1 - 0.98 9.2 4.9 0.28 11.0 0.2 2.5 3 1 0 3 3 3 0 Prion-inhibition and propagation Occludin_ELL PF07303.13 EEA19672.1 - 4.9 7.9 8.8 0.23 12.2 1.0 2.7 2 1 1 3 3 3 0 Occludin homology domain SH2_2 PF14633.6 EEA19673.1 - 6.8e-88 293.7 0.0 2.5e-87 291.8 0.0 2.0 1 0 0 1 1 1 1 SH2 domain HTH_44 PF14641.6 EEA19673.1 - 7.3e-37 126.3 0.7 7.3e-37 126.3 0.7 2.2 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 EEA19673.1 - 1.8e-27 95.7 0.0 4.1e-27 94.6 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 EEA19673.1 - 1.4e-22 80.1 0.0 1.1e-21 77.1 0.0 2.6 2 1 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 EEA19673.1 - 1.1e-14 54.8 12.1 1.1e-14 54.8 12.1 7.2 6 2 1 7 7 7 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 EEA19673.1 - 1.2e-07 32.5 3.6 4e-06 27.6 3.6 3.3 1 1 0 1 1 1 1 HHH domain SH2 PF00017.24 EEA19673.1 - 5.4e-06 26.4 0.0 1.4e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.7 EEA19673.1 - 0.0003 21.0 0.0 0.00077 19.7 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif Tex_N PF09371.10 EEA19673.1 - 0.083 12.6 7.1 0.1 12.3 0.0 3.9 4 0 0 4 4 4 0 Tex-like protein N-terminal domain Pkinase PF00069.25 EEA19674.1 - 3.2e-63 213.6 0.0 4.2e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19674.1 - 3e-34 118.5 0.0 4.3e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA19674.1 - 3.5e-06 26.1 0.4 1.1e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EEA19674.1 - 0.00081 18.8 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EEA19674.1 - 0.02 14.0 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 EEA19674.1 - 0.042 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 EEA19674.1 - 0.044 12.7 0.0 0.044 12.7 0.0 1.8 2 1 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 EEA19674.1 - 0.064 13.2 0.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Abhydrolase_3 PF07859.13 EEA19675.1 - 3.1e-63 213.4 0.0 4.1e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA19675.1 - 1.2e-09 37.7 0.1 3.5e-09 36.1 0.1 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 EEA19675.1 - 0.00035 21.2 0.1 0.00058 20.5 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 EEA19675.1 - 0.00096 18.1 0.0 0.0015 17.5 0.0 1.5 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 EEA19675.1 - 0.0035 16.3 0.0 0.0048 15.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EEA19675.1 - 0.0096 15.0 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase Peptidase_S9 PF00326.21 EEA19675.1 - 0.0097 15.4 0.9 0.044 13.3 0.2 2.2 2 1 0 2 2 2 1 Prolyl oligopeptidase family Ribonuc_L-PSP PF01042.21 EEA19676.1 - 2e-39 134.4 0.0 2.2e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Fungal_trans PF04082.18 EEA19677.1 - 1.4e-46 158.7 0.3 2.6e-46 157.8 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA19677.1 - 7.6e-07 29.3 9.4 0.00036 20.8 1.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA19677.1 - 2.7e-05 24.4 1.8 2.7e-05 24.4 1.8 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA19677.1 - 0.0011 19.6 0.6 0.0011 19.6 0.6 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger nlz1 PF12402.8 EEA19677.1 - 0.17 12.3 2.5 0.22 12.0 0.1 2.4 3 0 0 3 3 3 0 NocA-like zinc-finger protein 1 F-box-like PF12937.7 EEA19678.1 - 0.00024 20.9 1.7 0.00073 19.4 1.7 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA19678.1 - 0.0061 16.4 3.9 0.013 15.3 1.9 2.5 2 0 0 2 2 2 1 F-box domain DUF1033 PF06279.11 EEA19678.1 - 0.0073 16.5 2.2 0.015 15.4 2.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1033) Cation_efflux PF01545.21 EEA19679.1 - 1.5e-25 90.2 8.2 1.9e-25 89.8 8.2 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EEA19679.1 - 4.4e-08 33.1 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter XhlA PF10779.9 EEA19680.1 - 2.4 8.4 7.0 2.3 8.5 3.3 2.9 1 1 1 2 2 2 0 Haemolysin XhlA HMGL-like PF00682.19 EEA19681.1 - 3.2e-46 158.0 0.0 4.5e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 HMGL-like ECH_1 PF00378.20 EEA19681.1 - 3.7e-23 82.1 0.0 6.7e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA19681.1 - 2.5e-19 70.0 0.0 3.9e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase MFS_1 PF07690.16 EEA19682.1 - 2.6e-20 72.6 53.2 2.8e-20 72.6 49.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF485 PF04341.12 EEA19682.1 - 0.014 15.3 3.2 0.014 15.3 3.2 4.2 2 2 2 4 4 4 0 Protein of unknown function, DUF485 STIL_N PF15253.6 EEA19682.1 - 0.13 11.1 1.6 0.2 10.6 1.6 1.1 1 0 0 1 1 1 0 SCL-interrupting locus protein N-terminus Pterin_4a PF01329.19 EEA19683.1 - 3.2e-20 72.1 0.0 3.8e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase DUF4957 PF16318.5 EEA19683.1 - 0.011 15.6 0.0 0.016 15.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4957) Zn_clus PF00172.18 EEA19684.1 - 2.5e-08 33.9 12.0 4e-08 33.2 12.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EEA19684.1 - 6.8 6.6 12.3 9.3 6.1 12.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Aldose_epim PF01263.20 EEA19685.1 - 4.3e-60 203.6 0.1 5.2e-60 203.3 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase RVT_2 PF07727.14 EEA19686.1 - 9.4e-11 41.8 0.0 1.6e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA19686.1 - 1.7e-07 31.4 0.3 5.7e-06 26.5 0.0 2.9 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 EEA19686.1 - 0.00023 21.0 0.2 0.00075 19.3 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA19686.1 - 0.15 12.3 0.1 0.8 9.9 0.1 2.3 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Integrase_H2C2 PF17921.1 EEA19686.1 - 0.88 9.7 8.7 0.47 10.6 0.1 3.6 3 0 0 3 3 3 0 Integrase zinc binding domain Ank_2 PF12796.7 EEA19687.1 - 2.2e-97 319.8 19.9 1.1e-16 61.2 0.0 8.2 2 2 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA19687.1 - 6.5e-75 238.1 1.2 0.00076 19.7 0.0 16.4 16 0 0 16 16 16 15 Ankyrin repeat Ank_4 PF13637.6 EEA19687.1 - 1.3e-73 242.5 3.1 1.1e-09 38.6 0.0 10.8 7 3 3 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 EEA19687.1 - 1.6e-69 227.5 8.8 0.00078 19.8 0.0 15.6 15 0 0 15 15 15 15 Ankyrin repeat Ank_5 PF13857.6 EEA19687.1 - 4e-65 215.0 11.2 2.9e-05 24.3 0.0 15.3 1 1 14 15 15 15 15 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 EEA19687.1 - 4.1e-11 42.6 0.0 7.1e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily DUF1191 PF06697.12 EEA19687.1 - 0.0018 18.1 1.3 69 3.1 0.0 5.4 4 1 2 6 6 6 0 Protein of unknown function (DUF1191) NACHT PF05729.12 EEA19687.1 - 0.0029 17.5 0.0 0.0068 16.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain PEGA PF08308.11 EEA19687.1 - 0.0034 17.2 3.9 56 3.7 0.0 6.8 10 0 0 10 10 10 0 PEGA domain Lipase_GDSL_2 PF13472.6 EEA19688.1 - 1.9e-12 48.0 0.7 2.3e-12 47.7 0.7 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EEA19688.1 - 7.5e-06 26.1 0.0 9.4e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF1330 PF07045.11 EEA19688.1 - 0.056 13.8 0.0 5.3 7.4 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1330) NLPC_P60 PF00877.19 EEA19688.1 - 0.094 12.8 0.0 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 NlpC/P60 family PP28 PF10252.9 EEA19689.1 - 3.3e-30 104.4 16.0 3.3e-30 104.4 16.0 2.9 2 1 1 3 3 3 2 Casein kinase substrate phosphoprotein PP28 Nop53 PF07767.11 EEA19689.1 - 1.6 8.0 45.4 0.11 11.8 11.2 2.1 1 1 1 2 2 2 0 Nop53 (60S ribosomal biogenesis) UNC-50 PF05216.13 EEA19690.1 - 5.1e-86 287.8 9.4 7.4e-86 287.3 9.4 1.2 1 0 0 1 1 1 1 UNC-50 family PhyH PF05721.13 EEA19690.1 - 1.1e-26 94.4 0.0 1.6e-26 93.8 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) CorA PF01544.18 EEA19691.1 - 2.4e-08 33.7 0.7 2.4e-08 33.7 0.7 2.2 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein Arg_repressor PF01316.21 EEA19691.1 - 0.065 13.0 0.2 0.15 11.8 0.2 1.6 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain EMP70 PF02990.16 EEA19691.1 - 0.074 11.7 1.0 0.11 11.2 1.0 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 HSBP1 PF06825.12 EEA19691.1 - 0.084 12.7 2.5 0.13 12.1 1.2 1.9 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF2207 PF09972.9 EEA19691.1 - 0.17 10.6 0.0 0.17 10.6 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Presenilin PF01080.17 EEA19691.1 - 3.4 6.3 5.1 12 4.5 5.3 1.8 2 0 0 2 2 2 0 Presenilin DUF4407 PF14362.6 EEA19691.1 - 3.9 6.7 5.8 10 5.4 5.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF349 PF03993.12 EEA19691.1 - 5.6 7.3 9.2 0.26 11.6 1.6 2.6 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) Ank_2 PF12796.7 EEA19692.1 - 2.4e-87 287.6 15.4 4.9e-14 52.7 0.3 9.0 2 1 8 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 EEA19692.1 - 2e-73 239.9 3.4 2e-05 24.8 0.0 16.4 16 0 0 16 16 16 12 Ankyrin repeat Ank_4 PF13637.6 EEA19692.1 - 2.8e-67 222.3 10.2 9.1e-08 32.5 0.0 14.7 4 3 12 16 16 16 15 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA19692.1 - 4.4e-60 199.0 11.3 1.4e-06 28.5 0.2 13.5 8 3 5 13 13 13 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19692.1 - 1.6e-55 178.6 1.1 2.3e-05 24.4 0.0 16.8 17 0 0 17 17 17 12 Ankyrin repeat DUF5624 PF18538.1 EEA19692.1 - 0.15 12.1 0.0 1.7 8.8 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5624) Methyltransf_23 PF13489.6 EEA19693.1 - 5.7e-22 78.3 0.1 1.1e-21 77.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19693.1 - 1.6e-10 41.0 0.0 5.8e-10 39.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19693.1 - 3.8e-10 40.4 0.0 1.9e-09 38.1 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA19693.1 - 3.1e-07 31.1 0.0 1.4e-06 29.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19693.1 - 6.8e-07 29.8 0.0 9e-06 26.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 EEA19693.1 - 0.00029 21.0 0.0 0.00044 20.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase TagF_N PF09867.9 EEA19693.1 - 0.0093 16.0 0.4 0.087 12.9 0.1 2.3 1 1 1 2 2 2 1 TagF N-terminal domain, Type VI secretion system-associated MTS PF05175.14 EEA19693.1 - 0.0097 15.5 0.0 0.022 14.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EEA19693.1 - 0.015 14.8 1.1 0.071 12.6 0.0 2.5 3 1 0 3 3 3 0 Putative methyltransferase Tektin PF03148.14 EEA19693.1 - 0.069 11.9 0.5 0.11 11.2 0.5 1.3 1 0 0 1 1 1 0 Tektin family PrmA PF06325.13 EEA19693.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EEA19693.1 - 0.14 11.5 0.0 0.45 9.8 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family TrmB PF01978.19 EEA19693.1 - 0.19 11.6 0.1 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB CoA_transf_3 PF02515.17 EEA19694.1 - 5.6e-51 173.8 0.0 7.5e-51 173.4 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III F-box-like PF12937.7 EEA19695.1 - 0.017 15.0 0.0 0.074 13.0 0.0 2.2 1 0 0 1 1 1 0 F-box-like Sugar_tr PF00083.24 EEA19696.1 - 9.2e-122 407.1 20.9 1.4e-121 406.5 20.9 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19696.1 - 2.3e-30 105.7 62.8 3.7e-25 88.6 35.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Na_Ca_ex PF01699.24 EEA19697.1 - 3.3e-30 105.0 21.1 3.8e-15 56.2 5.2 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF1616 PF07760.11 EEA19698.1 - 0.093 12.1 2.2 0.71 9.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) Abhydrolase_1 PF00561.20 EEA19699.1 - 1e-24 87.6 0.0 1.7e-24 86.9 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA19699.1 - 1.5e-12 48.6 0.1 2.2e-12 48.0 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19699.1 - 5.5e-07 29.1 0.0 0.00043 19.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EEA19699.1 - 0.074 12.0 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S15 PF02129.18 EEA19699.1 - 0.1 12.2 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Glyco_hydro_30 PF02055.16 EEA19700.1 - 2.7e-11 43.1 0.0 3.9e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 EEA19700.1 - 3e-09 36.5 0.1 4.4e-09 36.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30C PF17189.4 EEA19700.1 - 6.4e-08 32.7 0.6 1.8e-07 31.2 0.6 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydr_30_2 PF14587.6 EEA19700.1 - 0.0032 17.1 2.1 0.013 15.1 0.0 2.6 2 1 1 3 3 3 1 O-Glycosyl hydrolase family 30 Big_7 PF17957.1 EEA19700.1 - 2.1 9.2 6.2 6.2 7.7 0.1 3.4 3 0 0 3 3 3 0 Bacterial Ig domain Fungal_trans PF04082.18 EEA19701.1 - 1.3e-09 37.5 1.7 3.1e-09 36.2 1.7 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF3759 PF12585.8 EEA19702.1 - 8.2e-38 128.3 4.0 1.1e-37 128.0 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) ECR1_N PF14382.6 EEA19703.1 - 4.3e-13 48.8 1.4 1.2e-12 47.4 1.1 1.9 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EEA19703.1 - 1.4e-05 25.3 0.6 3.1e-05 24.2 0.6 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 EEA19703.1 - 0.0098 16.5 2.0 0.53 10.9 0.1 2.9 3 0 0 3 3 3 1 Exosome component EXOSC1/CSL4 Ribosomal_L7Ae PF01248.26 EEA19704.1 - 1.9e-07 30.7 0.1 4.4e-07 29.5 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CRAL_TRIO PF00650.20 EEA19706.1 - 1.2e-39 135.6 0.2 1.8e-39 135.0 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA19706.1 - 7.3e-11 42.1 0.1 2.5e-10 40.4 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EEA19706.1 - 2.4e-09 37.4 0.1 4.2e-09 36.7 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Fungal_trans PF04082.18 EEA19707.1 - 1.1e-09 37.8 0.5 1.5e-09 37.3 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain YesK PF14150.6 EEA19707.1 - 0.0063 16.7 4.6 1.8 8.8 0.2 3.1 2 2 0 2 2 2 2 YesK-like protein Sec7 PF01369.20 EEA19710.1 - 1.1e-26 93.7 0.0 2.3e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EEA19710.1 - 3.1e-19 69.5 0.0 1.4e-18 67.4 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Ino80_Iec3 PF14612.6 EEA19711.1 - 1.4e-81 274.6 4.4 1.4e-81 274.6 4.4 1.6 2 0 0 2 2 2 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling Ino80_Iec3 PF14612.6 EEA19712.1 - 2.6e-80 270.5 4.1 2.6e-80 270.5 4.1 1.6 2 0 0 2 2 2 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling RRM_1 PF00076.22 EEA19713.1 - 5.8e-22 77.3 0.6 8.2e-13 48.0 0.0 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA19713.1 - 0.0014 18.6 0.3 0.44 10.6 0.0 2.6 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Spt20 PF12090.8 EEA19713.1 - 0.025 14.2 0.9 0.025 14.2 0.9 1.9 2 0 0 2 2 2 0 Spt20 family Spt5_N PF11942.8 EEA19713.1 - 0.031 15.2 14.9 0.031 15.2 14.9 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal RRM_7 PF16367.5 EEA19713.1 - 0.066 13.3 0.0 0.83 9.8 0.0 2.5 2 1 0 2 2 2 0 RNA recognition motif DNA_pol_phi PF04931.13 EEA19713.1 - 0.26 9.3 11.7 0.37 8.8 11.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi ORC6 PF05460.13 EEA19713.1 - 0.66 9.2 7.6 0.026 13.8 1.1 1.8 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) RR_TM4-6 PF06459.12 EEA19713.1 - 1.2 8.9 15.0 0.12 12.2 4.5 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 GNAT_acetyltr_2 PF13718.6 EEA19713.1 - 2.6 7.4 4.9 0.23 10.9 0.2 1.5 2 0 0 2 2 2 0 GNAT acetyltransferase 2 YL1 PF05764.13 EEA19713.1 - 2.8 8.0 26.1 0.065 13.3 14.5 2.3 2 0 0 2 2 2 0 YL1 nuclear protein RRN3 PF05327.11 EEA19713.1 - 3.5 6.1 6.0 6.1 5.3 6.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GEN1_C PF18380.1 EEA19713.1 - 4.3 8.3 20.7 0.13 13.1 9.8 2.8 2 1 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain CCDC106 PF15794.5 EEA19713.1 - 7.5 6.2 14.2 0.098 12.3 5.8 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Btz PF09405.10 EEA19714.1 - 2.8e-29 102.0 4.6 6.4e-29 100.8 4.6 1.6 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding N_BRCA1_IG PF16158.5 EEA19715.1 - 4e-31 107.8 0.2 1.3e-30 106.1 0.2 2.0 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EEA19715.1 - 2.2e-23 81.8 49.7 1.7e-08 34.1 8.0 4.4 4 0 0 4 4 4 4 Zinc finger, ZZ type C1_2 PF03107.16 EEA19715.1 - 1.3 9.4 46.4 0.7 10.3 5.5 4.5 4 0 0 4 4 4 0 C1 domain adh_short_C2 PF13561.6 EEA19717.1 - 3.7e-14 52.8 0.2 5e-14 52.4 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA19717.1 - 1.6e-13 50.5 0.2 3.2e-13 49.6 0.3 1.4 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 EEA19717.1 - 0.00038 20.0 0.0 0.00072 19.1 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA19717.1 - 0.013 15.4 0.2 0.019 14.9 0.2 1.5 1 1 0 1 1 1 0 NAD(P)H-binding AAA_22 PF13401.6 EEA19717.1 - 0.039 14.2 0.0 8.5 6.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain RmlD_sub_bind PF04321.17 EEA19717.1 - 0.08 12.0 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain ApbA PF02558.16 EEA19717.1 - 0.097 12.3 0.2 0.89 9.2 0.1 2.2 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 EEA19717.1 - 0.099 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EEA19717.1 - 0.11 13.1 0.0 0.37 11.4 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Glyco_transf_20 PF00982.21 EEA19718.1 - 1.4e-148 495.5 0.0 2e-148 495.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EEA19718.1 - 2.2e-82 275.7 0.0 7.5e-82 274.0 0.0 1.8 2 0 0 2 2 2 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 EEA19718.1 - 0.017 14.8 0.0 1 9.0 0.0 2.2 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Macro_2 PF14519.6 EEA19721.1 - 7.6e-08 32.0 0.0 1.1e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Macro-like domain PAP_assoc PF03828.19 EEA19722.1 - 0.057 13.6 0.0 0.65 10.2 0.0 2.4 1 1 0 1 1 1 0 Cid1 family poly A polymerase DUF1823 PF08853.11 EEA19722.1 - 0.14 12.4 0.4 3.8 7.7 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1823) LETM1 PF07766.13 EEA19723.1 - 7.2e-10 38.7 0.1 5.8e-07 29.1 0.1 2.2 1 1 0 1 1 1 1 LETM1-like protein Isochorismatase PF00857.20 EEA19724.1 - 1.2e-16 61.4 0.0 5.1e-16 59.3 0.0 1.8 1 1 0 1 1 1 1 Isochorismatase family QRPTase_C PF01729.19 EEA19725.1 - 1.9e-48 164.4 0.2 1.7e-46 158.1 0.2 2.1 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EEA19725.1 - 7.7e-23 80.4 0.2 5.7e-22 77.6 0.0 2.4 2 1 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain TMP-TENI PF02581.17 EEA19725.1 - 0.024 14.0 0.1 0.039 13.3 0.1 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase QRPTase_C PF01729.19 EEA19726.1 - 1.9e-48 164.4 0.2 1.7e-46 158.1 0.2 2.1 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EEA19726.1 - 7.7e-23 80.4 0.2 5.7e-22 77.6 0.0 2.4 2 1 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain TMP-TENI PF02581.17 EEA19726.1 - 0.024 14.0 0.1 0.039 13.3 0.1 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase Cnn_1N PF07989.11 EEA19727.1 - 6.7e-23 80.6 11.3 6.7e-23 80.6 11.3 11.7 7 1 5 12 12 12 3 Centrosomin N-terminal motif 1 Mto2_bdg PF12808.7 EEA19727.1 - 2.5e-15 56.5 19.6 2.5e-15 56.5 19.6 11.4 14 0 0 14 14 14 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Fib_alpha PF08702.10 EEA19727.1 - 0.00059 20.0 8.2 0.00059 20.0 8.2 7.2 4 2 3 8 8 8 1 Fibrinogen alpha/beta chain family PRKG1_interact PF15898.5 EEA19727.1 - 0.0048 17.8 0.4 0.0048 17.8 0.4 12.5 4 2 9 13 13 13 1 cGMP-dependent protein kinase interacting domain DUF2935 PF11155.8 EEA19727.1 - 0.28 11.5 2.9 7.6 6.9 0.3 4.2 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Ras PF00071.22 EEA19728.1 - 4.8e-39 133.5 0.0 2.6e-37 127.9 0.0 2.2 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EEA19728.1 - 2.9e-11 43.6 0.0 1.2e-10 41.6 0.0 2.0 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA19728.1 - 2.5e-05 23.8 0.1 0.021 14.3 0.0 2.2 1 1 1 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA19728.1 - 0.0037 17.3 0.0 0.0074 16.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA19728.1 - 0.089 12.3 0.1 1.4 8.4 0.0 2.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain PAS_9 PF13426.7 EEA19729.1 - 4.6e-28 97.5 0.0 3.2e-16 59.5 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 EEA19729.1 - 4.3e-23 81.4 0.0 2.3e-13 50.2 0.0 3.9 4 0 0 4 4 4 3 PAS fold PAS PF00989.25 EEA19729.1 - 3.2e-16 59.3 0.0 3.3e-07 30.3 0.0 3.6 3 0 0 3 3 3 3 PAS fold GATA PF00320.27 EEA19729.1 - 9.9e-15 53.9 9.6 1.7e-14 53.1 8.9 1.9 2 0 0 2 2 2 1 GATA zinc finger PAS_11 PF14598.6 EEA19729.1 - 3.9e-09 36.6 0.0 3.2e-05 24.0 0.0 3.0 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 EEA19729.1 - 1.4e-08 35.0 0.0 0.0056 16.9 0.0 3.4 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 EEA19729.1 - 0.0032 17.4 0.0 0.058 13.4 0.0 2.4 2 0 0 2 2 2 1 PAS domain Nudix_N_2 PF14803.6 EEA19729.1 - 0.57 10.1 3.6 1.2 9.1 3.6 1.6 1 0 0 1 1 1 0 Nudix N-terminal PAS_9 PF13426.7 EEA19730.1 - 4.1e-28 97.7 0.0 3e-16 59.5 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 EEA19730.1 - 4.1e-23 81.5 0.0 2.2e-13 50.3 0.0 3.8 4 0 0 4 4 4 3 PAS fold PAS PF00989.25 EEA19730.1 - 2.9e-16 59.5 0.0 3.1e-07 30.4 0.0 3.6 3 0 0 3 3 3 3 PAS fold GATA PF00320.27 EEA19730.1 - 4.2e-15 55.1 7.4 7.5e-15 54.2 6.7 1.8 2 0 0 2 2 2 1 GATA zinc finger PAS_11 PF14598.6 EEA19730.1 - 3.6e-09 36.8 0.0 3.1e-05 24.1 0.0 3.0 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 EEA19730.1 - 1.3e-08 35.1 0.0 0.0054 17.0 0.0 3.4 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 EEA19730.1 - 0.003 17.5 0.0 0.056 13.5 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS_2 PF08446.11 EEA19730.1 - 0.17 12.6 0.0 9.7 6.9 0.0 2.8 2 0 0 2 2 2 0 PAS fold Nudix_N_2 PF14803.6 EEA19730.1 - 0.55 10.2 3.6 1.1 9.2 3.6 1.6 1 0 0 1 1 1 0 Nudix N-terminal PLDc PF00614.22 EEA19731.1 - 4.1e-15 55.2 0.2 2.6e-07 30.5 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EEA19731.1 - 5.6e-13 48.9 0.0 1.8e-06 27.9 0.0 3.2 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 EEA19731.1 - 1e-08 35.1 0.2 4.8e-08 33.0 0.0 2.3 2 0 0 2 2 2 1 PX domain Abhydrolase_6 PF12697.7 EEA19732.1 - 0.00097 19.8 0.1 0.0012 19.5 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA19732.1 - 0.0035 16.7 0.0 0.0094 15.2 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Helicase_C_2 PF13307.6 EEA19733.1 - 2.6e-56 190.5 0.0 8e-56 188.9 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EEA19733.1 - 1.2e-51 174.8 1.0 3e-51 173.5 1.0 1.7 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 EEA19733.1 - 0.0028 17.4 0.5 0.0074 16.0 0.0 1.9 2 0 0 2 2 2 1 Helical and beta-bridge domain DUF4349 PF14257.6 EEA19733.1 - 0.56 9.6 4.5 1.1 8.7 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) Sel1 PF08238.12 EEA19734.1 - 1.9e-20 72.8 21.0 1.9e-07 31.5 0.0 7.1 6 0 0 6 6 6 6 Sel1 repeat TPR_1 PF00515.28 EEA19734.1 - 0.0064 16.3 0.6 0.05 13.4 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA19734.1 - 1.6 9.0 0.0 1.6 9.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Med9 PF07544.13 EEA19735.1 - 0.086 12.9 1.3 0.19 11.8 1.3 1.6 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 TSC22 PF01166.18 EEA19735.1 - 0.25 11.7 1.8 0.44 10.9 0.1 2.0 2 0 0 2 2 2 0 TSC-22/dip/bun family bZIP_1 PF00170.21 EEA19735.1 - 0.51 10.5 2.9 6.3 7.0 0.5 2.2 2 0 0 2 2 2 0 bZIP transcription factor zf-CCCH PF00642.24 EEA19736.1 - 2.6e-11 43.1 9.3 2.7e-06 27.1 1.9 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EEA19736.1 - 7.3e-10 38.4 9.3 4.1e-06 26.5 2.2 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EEA19736.1 - 8.6e-09 35.2 16.4 4.7e-05 23.3 1.8 2.4 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EEA19736.1 - 2e-08 34.9 5.2 0.00088 19.9 0.3 2.7 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 EEA19736.1 - 1.1e-05 25.6 0.1 2.4e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EEA19736.1 - 0.0087 16.5 14.1 0.2 12.2 3.2 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Bromodomain PF00439.25 EEA19737.1 - 3e-38 129.8 7.3 4.4e-19 68.3 1.1 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EEA19737.1 - 1.2e-18 67.1 0.9 3.4e-18 65.6 0.9 1.8 1 0 0 1 1 1 1 BAH domain CDC45 PF02724.14 EEA19737.1 - 0.00039 18.9 4.4 0.00039 18.9 4.4 2.1 2 0 0 2 2 2 1 CDC45-like protein GCIP PF13324.6 EEA19737.1 - 0.17 11.5 1.7 0.35 10.4 1.7 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting OTU PF02338.19 EEA19738.1 - 6e-06 26.8 0.0 9.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Oxysterol_BP PF01237.18 EEA19739.1 - 5.6e-54 183.4 0.3 1.4e-44 152.5 0.0 2.2 1 1 1 2 2 2 2 Oxysterol-binding protein Oxysterol_BP PF01237.18 EEA19740.1 - 5.6e-54 183.4 0.3 1.4e-44 152.5 0.0 2.2 1 1 1 2 2 2 2 Oxysterol-binding protein Cnd1_N PF12922.7 EEA19741.1 - 5.1e-62 208.6 0.4 1.6e-61 207.0 0.4 1.9 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 EEA19741.1 - 2.7e-49 167.3 3.3 7.6e-44 149.6 0.9 3.8 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA19741.1 - 9.1e-12 45.2 3.7 3.1e-05 24.3 0.0 5.3 4 1 0 5 5 5 2 HEAT repeats HEAT PF02985.22 EEA19741.1 - 1.4e-09 37.4 9.1 0.058 13.7 0.0 6.6 6 0 0 6 6 6 3 HEAT repeat Adaptin_N PF01602.20 EEA19741.1 - 4.3e-07 28.9 5.6 0.18 10.3 0.1 4.3 3 1 0 3 3 3 2 Adaptin N terminal region RTP1_C1 PF10363.9 EEA19741.1 - 1.9e-05 24.8 0.3 0.21 11.8 0.0 4.1 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 EEA19741.1 - 0.00042 19.6 4.5 0.00084 18.6 0.8 3.3 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 EEA19741.1 - 0.00087 19.7 10.6 0.32 11.6 0.0 5.6 6 0 0 6 6 6 2 HEAT-like repeat Cohesin_HEAT PF12765.7 EEA19741.1 - 0.11 12.9 1.9 7.1 7.0 0.0 4.2 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion Pkinase PF00069.25 EEA19742.1 - 3e-42 144.8 0.0 1.9e-39 135.6 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19742.1 - 5.6e-10 38.9 0.0 8.5e-06 25.2 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EEA19742.1 - 0.002 18.1 0.1 0.45 10.4 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EEA19742.1 - 0.013 14.3 0.0 0.034 12.9 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Sigma70_ner PF04546.13 EEA19742.1 - 6.9 6.5 10.5 0.33 10.8 4.3 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region PCMT PF01135.19 EEA19743.1 - 1.1e-61 208.3 0.0 4.1e-61 206.4 0.0 1.7 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EEA19743.1 - 1.2e-05 25.2 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19743.1 - 8.9e-05 23.1 0.0 0.00038 21.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA19743.1 - 0.00026 20.8 0.0 0.00044 20.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EEA19743.1 - 0.00036 20.5 0.0 0.0006 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EEA19743.1 - 0.0074 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 EEA19743.1 - 0.017 15.9 0.0 0.06 14.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19743.1 - 0.062 14.0 0.0 0.23 12.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain GCD14 PF08704.10 EEA19743.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit MTS PF05175.14 EEA19743.1 - 0.19 11.2 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DnaJ PF00226.31 EEA19744.1 - 1.1e-21 76.7 0.5 3.9e-21 74.9 0.5 2.0 1 0 0 1 1 1 1 DnaJ domain TPR_19 PF14559.6 EEA19744.1 - 2e-17 63.4 0.2 0.00015 22.2 0.3 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA19744.1 - 3.3e-17 61.2 2.7 0.0018 18.2 0.0 7.2 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EEA19744.1 - 4.2e-16 58.0 0.0 7.2e-06 25.6 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EEA19744.1 - 1.1e-14 54.3 2.6 4.2e-05 23.6 0.3 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA19744.1 - 1.1e-12 47.6 5.1 0.074 13.9 0.0 6.9 4 3 3 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA19744.1 - 1.9e-12 46.3 2.6 0.0075 16.4 0.0 6.9 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA19744.1 - 7e-09 35.1 0.6 0.6 10.3 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA19744.1 - 6.2e-08 33.2 3.0 0.0012 19.5 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA19744.1 - 1.5e-07 31.5 7.5 0.0098 16.1 1.4 4.8 3 2 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EEA19744.1 - 1.6e-07 30.9 0.0 0.015 15.0 0.0 4.9 4 1 1 5 5 5 2 TPR repeat TPR_6 PF13174.6 EEA19744.1 - 1.7e-07 31.4 9.8 2 9.2 0.0 8.2 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA19744.1 - 1.4e-05 25.1 0.0 0.032 14.6 0.0 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA19744.1 - 4.2e-05 23.7 5.6 0.066 13.5 0.0 4.9 4 2 0 4 4 4 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EEA19744.1 - 0.00068 19.3 0.0 0.0052 16.4 0.0 2.4 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) PknG_TPR PF16918.5 EEA19744.1 - 0.014 14.2 0.0 0.42 9.3 0.0 2.7 3 0 0 3 3 3 0 Protein kinase G tetratricopeptide repeat TPR_20 PF14561.6 EEA19744.1 - 0.027 14.8 2.4 1.9 8.9 0.0 4.0 3 2 1 4 4 4 0 Tetratricopeptide repeat KORA PF16509.5 EEA19744.1 - 0.031 14.5 1.4 0.082 13.2 0.3 2.3 2 1 0 2 2 2 0 TrfB plasmid transcriptional repressor GCIP PF13324.6 EEA19744.1 - 0.043 13.4 2.8 0.045 13.3 0.6 1.9 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Fis1_TPR_C PF14853.6 EEA19744.1 - 0.063 13.4 3.9 2.5 8.2 0.0 4.1 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat Med15 PF09606.10 EEA19744.1 - 0.086 11.5 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal HAD_2 PF13419.6 EEA19744.1 - 0.12 12.5 1.1 33 4.5 0.0 3.2 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase ClpS PF02617.17 EEA19744.1 - 0.25 11.1 1.2 1 9.2 0.1 2.5 3 0 0 3 3 2 0 ATP-dependent Clp protease adaptor protein ClpS DsrD PF08679.11 EEA19744.1 - 7.5 6.9 5.9 1.1e+02 3.2 0.5 3.3 3 0 0 3 3 3 0 Dissimilatory sulfite reductase D (DsrD) PCRF PF03462.18 EEA19745.1 - 3.6e-50 170.5 0.0 1.8e-49 168.3 0.0 2.0 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EEA19745.1 - 1.6e-33 115.0 1.5 3.3e-33 114.1 1.5 1.5 1 0 0 1 1 1 1 RF-1 domain Mito_carr PF00153.27 EEA19746.1 - 2.7e-52 174.7 4.5 3.3e-23 81.4 0.2 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein AgrB PF04647.15 EEA19746.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Accessory gene regulator B DEAD PF00270.29 EEA19747.1 - 6.3e-43 146.6 0.1 8.9e-43 146.1 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA19747.1 - 3.4e-28 98.2 1.0 6.2e-27 94.1 0.4 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA19747.1 - 0.0018 18.3 0.0 0.0033 17.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EEA19747.1 - 0.15 11.4 0.0 0.35 10.2 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit GRP PF07172.11 EEA19747.1 - 0.49 11.1 15.1 1 10.1 15.1 1.4 1 0 0 1 1 1 0 Glycine rich protein family SMC_N PF02463.19 EEA19748.1 - 1.4e-20 73.7 10.6 1e-19 70.9 10.6 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EEA19748.1 - 4e-17 63.4 6.6 4e-17 63.4 6.6 5.5 2 2 1 3 3 3 1 AAA domain AAA_15 PF13175.6 EEA19748.1 - 2.3e-11 44.0 12.9 2.3e-11 44.0 12.9 3.7 2 2 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EEA19748.1 - 3.5e-07 30.3 14.3 3.2e-06 27.2 1.8 4.2 3 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_hinge PF06470.13 EEA19748.1 - 9.5e-06 25.9 0.7 0.00013 22.2 0.0 2.8 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_29 PF13555.6 EEA19748.1 - 0.0007 19.3 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EEA19748.1 - 0.073 13.6 0.1 0.073 13.6 0.1 5.9 3 2 0 3 3 3 0 ABC transporter DUF5104 PF17117.5 EEA19748.1 - 0.16 12.4 1.0 22 5.5 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5104) Caskin-tail PF16632.5 EEA19748.1 - 0.2 12.1 9.8 2.4 8.6 0.1 3.7 3 0 0 3 3 3 0 C-terminal region of Caskin Spc7 PF08317.11 EEA19748.1 - 3.5 6.4 86.1 0.029 13.3 12.8 5.7 3 2 3 6 6 6 0 Spc7 kinetochore protein Peptidase_M20 PF01546.28 EEA19749.1 - 6.5e-33 114.2 0.0 8.3e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA19749.1 - 2.3e-13 50.0 0.0 4.1e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EEA19749.1 - 0.038 13.7 0.0 0.085 12.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M28 MRP-L20 PF12824.7 EEA19750.1 - 1.3e-34 119.7 4.4 1.6e-34 119.5 4.4 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 EEA19750.1 - 0.055 13.5 0.9 0.076 13.0 0.9 1.2 1 0 0 1 1 1 0 Neugrin Cys_Met_Meta_PP PF01053.20 EEA19751.1 - 4.8e-32 110.9 0.0 6.3e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EEA19751.1 - 0.0012 18.1 0.0 0.0018 17.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Nrap_D4 PF17405.2 EEA19752.1 - 2.2e-57 193.8 0.3 3.8e-57 193.1 0.3 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EEA19752.1 - 7.9e-54 181.8 0.4 1.6e-53 180.8 0.1 1.7 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 EEA19752.1 - 3.1e-42 143.9 0.5 2.2e-40 137.9 0.0 3.3 3 0 0 3 3 3 1 Nrap protein PAP/OAS-like domain Nrap PF03813.14 EEA19752.1 - 9.7e-42 142.6 0.2 1.8e-41 141.7 0.2 1.5 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 EEA19752.1 - 1.4e-41 142.2 0.0 9.1e-41 139.6 0.0 2.1 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EEA19752.1 - 2.1e-29 102.4 0.0 6.4e-29 100.9 0.0 1.9 1 0 0 1 1 1 1 Nrap protein domain 6 DUF948 PF06103.11 EEA19752.1 - 0.032 14.5 0.0 0.28 11.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Peptidase_C12 PF01088.21 EEA19754.1 - 2.1e-37 128.9 0.0 1.3e-33 116.5 0.0 2.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase, family 1 CSTF_C PF14304.6 EEA19754.1 - 0.084 12.5 0.1 0.2 11.2 0.1 1.6 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal Peptidase_C12 PF01088.21 EEA19755.1 - 2.8e-54 184.1 0.0 3.5e-54 183.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 2-oxoacid_dh PF00198.23 EEA19757.1 - 1.5e-80 270.0 0.0 2.1e-80 269.5 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EEA19757.1 - 7.8e-19 67.3 2.5 1.5e-18 66.4 2.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EEA19757.1 - 8.8e-05 22.3 0.2 0.0024 17.6 0.1 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 EEA19757.1 - 0.0002 22.0 0.3 0.033 14.9 0.1 2.5 1 1 1 2 2 2 1 HlyD family secretion protein RnfC_N PF13375.6 EEA19757.1 - 0.0092 15.9 0.2 0.32 11.0 0.0 2.6 1 1 1 2 2 2 1 RnfC Barrel sandwich hybrid domain GCV_H PF01597.19 EEA19757.1 - 0.099 12.5 0.4 0.21 11.5 0.4 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein Pneumo_att_G PF05539.11 EEA19757.1 - 0.38 10.3 1.3 0.5 9.9 1.3 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Presenilin PF01080.17 EEA19757.1 - 2.1 7.0 3.6 2.9 6.6 3.6 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EEA19757.1 - 3 7.6 9.7 4.2 7.1 9.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Complex1_LYR PF05347.15 EEA19758.1 - 4.9e-10 39.3 0.5 6.5e-10 38.9 0.5 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Histone_H2A_C PF16211.5 EEA19759.1 - 4.3e-21 74.4 2.8 7.6e-21 73.6 2.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EEA19759.1 - 2.8e-17 63.3 0.0 3.8e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA19759.1 - 1e-05 25.7 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA19760.1 - 9.7e-17 61.6 0.0 1.4e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EEA19760.1 - 5.8e-15 54.7 0.2 1.1e-14 53.8 0.2 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EEA19760.1 - 2.7e-05 24.3 0.0 4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA19761.1 - 1.5e-21 77.1 0.6 1.9e-21 76.8 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA19761.1 - 0.00021 21.5 0.0 0.00021 21.5 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EEA19761.1 - 0.00042 20.8 0.0 0.0007 20.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EEA19761.1 - 0.038 14.0 0.2 0.045 13.8 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein RP-C PF03428.13 EEA19761.1 - 0.044 13.4 0.1 0.11 12.2 0.1 1.6 1 1 0 1 1 1 0 Replication protein C N-terminal domain Peptidase_C54 PF03416.19 EEA19762.1 - 1.2e-97 326.7 0.0 1.5e-97 326.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 EEA19762.1 - 0.02 14.3 0.0 0.054 13.0 0.0 1.7 2 0 0 2 2 2 0 Peptidase family C78 R3H PF01424.22 EEA19763.1 - 8.2e-14 51.3 0.0 1.6e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 EEA19763.1 - 5.7e-10 38.9 1.8 7.2e-10 38.6 0.3 2.1 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EEA19763.1 - 0.00086 19.3 0.3 0.00086 19.3 0.3 2.7 2 0 0 2 2 2 1 G-patch domain Rotamase_3 PF13616.6 EEA19763.1 - 7.8 7.1 8.7 0.17 12.4 0.4 2.3 3 0 0 3 3 3 0 PPIC-type PPIASE domain DnaJ PF00226.31 EEA19764.1 - 5.2e-24 84.1 0.5 1.3e-23 82.9 0.5 1.7 1 0 0 1 1 1 1 DnaJ domain zf-met PF12874.7 EEA19764.1 - 3.5e-11 43.1 12.3 7.5e-08 32.5 3.7 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA19764.1 - 6.6e-11 42.2 14.6 1.1e-08 35.2 7.5 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EEA19764.1 - 3.6e-07 30.4 10.4 0.00088 19.6 2.1 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EEA19764.1 - 2.1e-06 28.0 7.0 0.013 16.2 0.8 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA19764.1 - 2.6e-05 24.4 9.6 0.046 14.2 1.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type RPT PF13446.6 EEA19764.1 - 0.03 14.3 0.0 0.1 12.5 0.0 1.9 1 0 0 1 1 1 0 A repeated domain in UCH-protein zf-C2H2_6 PF13912.6 EEA19764.1 - 0.068 13.2 11.7 0.046 13.7 3.4 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger LIM PF00412.22 EEA19764.1 - 1.5 9.1 4.6 1.3 9.3 0.8 2.3 2 0 0 2 2 2 0 LIM domain YccV-like PF08755.11 EEA19765.1 - 4.2e-29 100.9 0.1 1.1e-28 99.7 0.1 1.7 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.6 EEA19765.1 - 5.4e-16 58.5 0.0 1e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 EEA19765.1 - 5.5e-10 39.0 1.2 1.1e-09 38.0 1.2 1.6 1 0 0 1 1 1 1 F-box-like Elongin_A PF06881.11 EEA19765.1 - 4.2e-07 30.4 0.3 8.7e-07 29.4 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.33 EEA19765.1 - 7.8e-07 28.8 0.2 1.8e-06 27.6 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.6 EEA19765.1 - 0.1 12.6 2.3 3.6 7.6 2.3 2.6 1 1 0 1 1 1 0 F-box-like domain FA_hydroxylase PF04116.13 EEA19766.1 - 2.9e-25 89.1 17.3 2.9e-25 89.1 17.3 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily FA_hydroxylase PF04116.13 EEA19767.1 - 3.4e-25 88.9 17.3 3.4e-25 88.9 17.3 2.4 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily HTH_Tnp_Tc5 PF03221.16 EEA19768.1 - 1.8e-13 50.3 0.1 3.3e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA19768.1 - 1.3e-05 24.9 0.1 4.2e-05 23.2 0.1 1.9 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.6 EEA19768.1 - 0.0009 19.3 0.2 0.0051 16.9 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 EEA19768.1 - 0.0031 17.5 0.6 0.31 11.1 0.1 3.0 3 0 0 3 3 3 1 Winged helix-turn helix DUF2089 PF09862.9 EEA19768.1 - 0.019 15.0 0.2 0.038 14.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) HTH_23 PF13384.6 EEA19768.1 - 0.022 14.6 0.3 0.61 10.0 0.1 2.5 2 0 0 2 2 2 0 Homeodomain-like domain HTH_17 PF12728.7 EEA19768.1 - 0.5 10.6 2.7 18 5.6 0.8 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain Asp PF00026.23 EEA19769.1 - 4.1e-33 115.1 0.0 5.2e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA19769.1 - 0.00097 19.7 0.1 1.5 9.5 0.0 2.8 3 0 0 3 3 3 2 Aspartyl protease TAXi_N PF14543.6 EEA19769.1 - 0.18 12.0 0.1 7 6.8 0.1 2.8 3 0 0 3 3 3 0 Xylanase inhibitor N-terminal zf-RVT PF13966.6 EEA19770.1 - 0.0025 18.5 0.1 0.0055 17.4 0.1 1.7 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase DDE_1 PF03184.19 EEA19771.1 - 6.9e-20 71.4 0.0 3.7e-19 69.0 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA19771.1 - 6.7e-15 54.9 1.0 7.5e-14 51.5 0.0 2.8 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain Med9 PF07544.13 EEA19771.1 - 0.025 14.7 1.3 0.21 11.7 0.6 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HTH_24 PF13412.6 EEA19771.1 - 0.059 12.9 0.0 0.19 11.3 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 EEA19771.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 LexA DNA binding domain DDE_1 PF03184.19 EEA19772.1 - 3.8e-27 95.0 0.0 5.9e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA19772.1 - 1.6e-12 47.3 0.0 5.8e-12 45.5 0.0 2.1 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA19772.1 - 0.00034 20.3 0.1 0.00097 18.8 0.0 1.8 2 0 0 2 2 2 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EEA19772.1 - 0.035 13.9 0.0 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_DeoR PF08220.12 EEA19772.1 - 0.093 12.5 0.3 0.29 10.9 0.2 1.9 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain RNase_H PF00075.24 EEA19773.1 - 6.9e-13 49.0 0.2 1.9e-12 47.6 0.0 1.9 2 1 0 2 2 2 1 RNase H DUF2934 PF11154.8 EEA19773.1 - 2 8.2 6.8 0.14 11.8 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2934) HTH_Tnp_Tc5 PF03221.16 EEA19774.1 - 1e-12 47.9 0.0 3.7e-12 46.1 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 EEA19774.1 - 0.0083 15.8 0.1 0.29 10.8 0.0 3.0 3 1 1 4 4 4 1 DDE superfamily endonuclease Tn7_Tnp_TnsA_C PF08721.11 EEA19774.1 - 0.009 16.6 0.6 0.069 13.8 0.1 2.7 2 0 0 2 2 2 1 TnsA endonuclease C terminal HTH_23 PF13384.6 EEA19775.1 - 1e-13 50.6 0.0 3.1e-05 23.6 0.0 3.4 3 0 0 3 3 3 2 Homeodomain-like domain HTH_32 PF13565.6 EEA19775.1 - 4.6e-13 49.6 8.5 5.9e-06 26.8 0.1 5.2 5 1 0 5 5 5 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 EEA19775.1 - 2.8e-11 43.5 0.1 5.7e-10 39.3 0.0 3.1 3 0 0 3 3 3 1 Transposase DDE_3 PF13358.6 EEA19775.1 - 1.6e-07 31.2 0.0 5.1e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease Sigma70_r4_2 PF08281.12 EEA19775.1 - 3.9e-07 29.6 1.0 0.038 13.7 0.1 2.9 3 0 0 3 3 3 2 Sigma-70, region 4 HTH_28 PF13518.6 EEA19775.1 - 9.9e-07 28.8 2.3 0.12 12.6 0.0 4.0 4 0 0 4 4 4 2 Helix-turn-helix domain TrmB PF01978.19 EEA19775.1 - 3.2e-06 26.9 0.6 0.17 11.8 0.0 3.0 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB HRDC PF00570.23 EEA19775.1 - 4.2e-05 23.4 0.1 0.49 10.4 0.0 2.6 2 0 0 2 2 2 2 HRDC domain HTH_29 PF13551.6 EEA19775.1 - 0.00019 21.4 0.0 3.3 7.8 0.0 4.2 4 2 0 4 4 3 2 Winged helix-turn helix KORA PF16509.5 EEA19775.1 - 0.0034 17.6 0.8 3.7 7.9 0.1 2.5 2 0 0 2 2 2 2 TrfB plasmid transcriptional repressor HTH_17 PF12728.7 EEA19775.1 - 0.0034 17.5 0.0 7.7 6.8 0.0 3.2 4 0 0 4 4 3 2 Helix-turn-helix domain DUF1492 PF07374.11 EEA19775.1 - 0.01 16.0 1.9 3.2 8.0 0.3 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1492) DUF2773 PF10971.8 EEA19775.1 - 0.011 15.9 0.2 8.3 6.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) DUF835 PF05763.12 EEA19775.1 - 0.014 15.1 4.5 2.5 7.8 0.1 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF835) Fe_dep_repress PF01325.19 EEA19775.1 - 0.027 14.7 0.0 17 5.7 0.0 2.7 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_IclR PF09339.10 EEA19775.1 - 0.052 13.4 0.0 24 4.8 0.0 3.2 3 0 0 3 3 3 0 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 EEA19775.1 - 0.077 13.0 0.0 27 4.8 0.0 3.1 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain DUF1681 PF07933.14 EEA19775.1 - 0.085 12.6 0.1 16 5.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1681) Sigma70_r4 PF04545.16 EEA19775.1 - 0.089 12.3 2.7 14 5.3 0.1 3.3 3 0 0 3 3 3 0 Sigma-70, region 4 MarR_2 PF12802.7 EEA19775.1 - 0.099 12.5 0.4 39 4.2 0.0 3.2 3 0 0 3 3 3 0 MarR family HTH_7 PF02796.15 EEA19775.1 - 0.11 12.6 2.3 18 5.5 0.2 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase ABC_tran PF00005.27 EEA19776.1 - 1e-16 61.7 0.0 1.8e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EEA19776.1 - 1.1e-06 28.5 3.9 6.4e-06 26.0 3.8 1.9 1 1 0 1 1 1 1 ABC transporter transmembrane region DnaB_C PF03796.15 EEA19776.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain SMC_N PF02463.19 EEA19776.1 - 0.14 11.6 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 EEA19777.1 - 1.1e-16 61.5 0.0 2.1e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EEA19777.1 - 9e-07 28.8 3.5 5.5e-06 26.2 3.4 2.0 1 1 0 1 1 1 1 ABC transporter transmembrane region DnaB_C PF03796.15 EEA19777.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain SMC_N PF02463.19 EEA19777.1 - 0.16 11.4 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Fcf1 PF04900.12 EEA19778.1 - 2.6e-38 130.4 1.0 6.8e-38 129.1 0.4 1.8 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EEA19778.1 - 1.4e-12 47.9 0.4 4.8e-12 46.2 0.1 1.8 2 0 0 2 2 2 1 PIN like domain XPG_I_2 PF12813.7 EEA19779.1 - 2.5e-92 308.9 0.0 3.4e-92 308.4 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.18 EEA19779.1 - 0.00021 21.6 0.0 0.0005 20.4 0.0 1.6 1 0 0 1 1 1 1 XPG I-region Utp21 PF04192.12 EEA19780.1 - 8.8e-73 244.6 0.0 1.4e-72 244.0 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EEA19780.1 - 2.8e-16 59.6 28.4 0.00023 21.9 0.4 10.6 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19780.1 - 3.2e-14 53.0 0.1 0.028 14.7 0.0 6.2 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 EEA19780.1 - 0.0098 14.9 0.3 0.2 10.5 0.0 3.0 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF5046 PF16465.5 EEA19780.1 - 0.049 13.1 0.0 0.29 10.5 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5046) eIF2A PF08662.11 EEA19780.1 - 0.089 12.7 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Bys1 PF04681.12 EEA19780.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Blastomyces yeast-phase-specific protein His_Phos_2 PF00328.22 EEA19781.1 - 1.1e-112 377.1 0.0 1.5e-112 376.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EEA19781.1 - 1.5e-37 127.6 0.0 3.3e-37 126.5 0.0 1.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EEA19781.1 - 9.7e-06 25.3 0.0 2.4e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain DUF676 PF05057.14 EEA19782.1 - 8.8e-41 139.8 0.0 2.8e-39 134.9 0.0 2.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Inositol_P PF00459.25 EEA19783.1 - 1.2e-65 221.8 0.0 1.4e-65 221.5 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF383 PF04063.14 EEA19784.1 - 5.6e-69 231.6 0.1 7e-68 228.1 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EEA19784.1 - 1.7e-21 75.8 3.6 8.7e-21 73.5 3.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF384) IBR PF01485.21 EEA19784.1 - 1.6e-12 47.5 35.1 5.7e-06 26.5 15.7 2.6 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain DUF2158 PF09926.9 EEA19784.1 - 0.0049 16.6 0.0 0.0085 15.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized small protein (DUF2158) TFIIF_alpha PF05793.12 EEA19785.1 - 4.6e-07 28.8 58.4 9.7e-07 27.7 9.9 2.9 1 1 1 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1729 PF08354.10 EEA19786.1 - 1.7e-158 527.2 0.0 2.6e-158 526.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EEA19786.1 - 2.9e-90 303.0 0.0 6.8e-89 298.5 0.0 2.5 2 0 0 2 2 2 1 Acyl transferase domain FAS_meander PF17951.1 EEA19786.1 - 4.9e-54 182.1 0.0 1.8e-53 180.3 0.0 2.0 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 EEA19786.1 - 6.9e-40 137.3 0.0 1.7e-39 136.0 0.0 1.7 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 EEA19786.1 - 2.6e-39 134.2 0.0 9.8e-39 132.3 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydratas PF01575.19 EEA19786.1 - 7.8e-38 128.8 0.0 1.7e-37 127.7 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EEA19786.1 - 3.8e-21 75.6 0.0 1.1e-20 74.2 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FAS_I_H PF18314.1 EEA19787.1 - 3e-77 258.8 0.0 8e-77 257.5 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EEA19787.1 - 3.1e-76 255.2 0.0 6.5e-76 254.2 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EEA19787.1 - 2.8e-22 79.5 0.0 5.1e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EEA19787.1 - 1.9e-18 66.7 0.0 4.6e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EEA19787.1 - 6.7e-11 42.2 0.0 1.9e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EEA19787.1 - 0.0074 16.2 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 KR domain TRM PF02005.16 EEA19788.1 - 1.7e-113 379.6 0.0 1e-99 334.3 0.0 2.1 1 1 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase DUF1691 PF07950.11 EEA19788.1 - 1.1e-38 132.2 4.1 5.8e-29 101.0 2.4 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Met_10 PF02475.16 EEA19788.1 - 1.1e-05 25.3 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EEA19788.1 - 0.2 11.2 0.0 0.4 10.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain zf-C2H2 PF00096.26 EEA19789.1 - 0.0037 17.7 1.2 0.0071 16.7 1.2 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.7 EEA19789.1 - 0.0061 16.9 0.3 0.011 16.2 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA19789.1 - 0.019 15.3 1.9 0.029 14.7 1.9 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Rotamase_2 PF13145.6 EEA19789.1 - 0.022 15.6 0.4 0.046 14.6 0.4 1.5 1 1 0 1 1 1 0 PPIC-type PPIASE domain DUF3592 PF12158.8 EEA19789.1 - 0.035 14.2 0.3 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3592) zf-C2H2_2 PF12756.7 EEA19789.1 - 0.073 13.4 0.2 0.11 12.8 0.2 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.11 EEA19789.1 - 0.084 12.8 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2_4 PF13894.6 EEA19789.1 - 0.092 13.6 0.5 0.21 12.5 0.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Transket_pyr PF02779.24 EEA19790.1 - 1.8e-47 161.3 0.0 5.3e-47 159.8 0.0 1.7 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EEA19790.1 - 2.2e-35 121.3 0.1 6.9e-35 119.6 0.0 1.9 2 0 0 2 2 2 1 Transketolase, C-terminal domain Metallophos PF00149.28 EEA19791.1 - 8.1e-12 46.1 3.0 8.8e-12 45.9 1.2 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EEA19791.1 - 0.017 15.3 0.0 0.062 13.5 0.0 1.8 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain ADH_zinc_N PF00107.26 EEA19792.1 - 4.4e-16 59.0 0.0 7.4e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA19792.1 - 0.0036 17.2 0.0 0.009 15.9 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Amidase PF01425.21 EEA19793.1 - 6.7e-118 394.5 0.3 8.2e-118 394.2 0.3 1.0 1 0 0 1 1 1 1 Amidase Eno-Rase_NADH_b PF12242.8 EEA19793.1 - 0.075 12.8 0.2 7.5 6.4 0.1 3.0 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Bystin PF05291.11 EEA19795.1 - 2.3e-131 437.4 0.0 3.6e-131 436.8 0.0 1.3 1 0 0 1 1 1 1 Bystin Bystin PF05291.11 EEA19796.1 - 1.1e-131 438.5 0.0 1.2e-131 438.3 0.0 1.0 1 0 0 1 1 1 1 Bystin bZIP_2 PF07716.15 EEA19797.1 - 6.8e-11 42.1 16.2 6.8e-11 42.1 16.2 2.6 2 1 1 3 3 3 2 Basic region leucine zipper bZIP_1 PF00170.21 EEA19797.1 - 2.9e-06 27.3 16.9 2.9e-06 27.3 16.9 1.9 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 EEA19797.1 - 0.0024 18.3 14.4 0.0024 18.3 14.4 1.9 2 0 0 2 2 2 1 bZIP Maf transcription factor APG6_N PF17675.1 EEA19797.1 - 0.1 13.1 14.5 0.12 12.9 12.9 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region Snf7 PF03357.21 EEA19798.1 - 0.0014 18.3 9.1 0.0019 17.8 9.1 1.2 1 0 0 1 1 1 1 Snf7 DUF4157 PF13699.6 EEA19798.1 - 0.016 15.5 1.4 0.016 15.5 1.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4157) MFS_1 PF07690.16 EEA19799.1 - 2.3e-28 99.1 28.6 8e-15 54.6 10.4 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19799.1 - 3.4e-06 26.2 24.3 0.00037 19.5 24.3 3.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 EEA19799.1 - 2.8e-05 22.8 24.3 0.0049 15.5 9.2 3.2 2 2 2 4 4 4 3 MFS/sugar transport protein MFS_1_like PF12832.7 EEA19799.1 - 6.1e-05 22.1 14.1 0.008 15.1 2.7 2.4 1 1 2 3 3 3 3 MFS_1 like family DUF1624 PF07786.12 EEA19799.1 - 0.0052 16.4 0.1 0.0052 16.4 0.1 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1624) LacY_symp PF01306.19 EEA19799.1 - 0.28 9.9 8.1 0.36 9.6 0.3 2.6 2 1 0 3 3 3 0 LacY proton/sugar symporter Fasciclin PF02469.22 EEA19800.1 - 3.2e-45 153.5 1.9 3.6e-25 88.7 0.1 2.2 2 0 0 2 2 2 2 Fasciclin domain Kin17_mid PF10357.9 EEA19801.1 - 6.7e-51 171.5 4.5 6.7e-51 171.5 4.5 1.8 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EEA19801.1 - 0.011 16.1 3.6 0.021 15.2 3.6 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA19801.1 - 0.013 15.8 2.7 0.03 14.6 2.7 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EEA19801.1 - 0.087 13.2 0.4 0.087 13.2 0.4 2.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Actin PF00022.19 EEA19802.1 - 8.2e-23 80.7 0.0 3.6e-20 72.0 0.0 2.9 3 0 0 3 3 3 2 Actin MFS_1 PF07690.16 EEA19803.1 - 2e-38 132.3 29.1 2e-38 132.3 29.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Epiglycanin_C PF14654.6 EEA19803.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.9 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region FixS PF03597.15 EEA19803.1 - 4 7.2 5.8 20 5.0 0.2 3.3 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type DUF3328 PF11807.8 EEA19804.1 - 1.8e-33 116.2 1.2 2.3e-33 115.8 1.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Hexokinase_1 PF00349.21 EEA19805.1 - 2.2e-49 168.1 0.0 3.1e-49 167.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EEA19805.1 - 7.6e-39 133.6 0.0 5e-38 130.9 0.0 2.0 1 1 0 1 1 1 1 Hexokinase CBFD_NFYB_HMF PF00808.23 EEA19806.1 - 2.5e-18 66.1 0.5 6.2e-18 64.9 0.5 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA19806.1 - 1e-06 29.1 1.0 1.3e-06 28.8 0.1 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 SPOB_ab PF14682.6 EEA19806.1 - 0.018 15.1 0.1 0.024 14.7 0.1 1.2 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal Bromo_TP PF07524.13 EEA19806.1 - 0.02 14.9 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated DUF5333 PF17267.2 EEA19806.1 - 0.05 13.8 0.5 0.065 13.4 0.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5333) CBFD_NFYB_HMF PF00808.23 EEA19807.1 - 5.5e-16 58.6 0.8 1.4e-15 57.3 0.8 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA19807.1 - 0.00019 21.8 0.1 0.00019 21.8 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 SPOB_ab PF14682.6 EEA19807.1 - 0.023 14.8 0.1 0.031 14.4 0.1 1.2 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal Bromo_TP PF07524.13 EEA19807.1 - 0.026 14.5 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated DUF5333 PF17267.2 EEA19807.1 - 0.058 13.6 0.5 0.082 13.1 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5333) adh_short PF00106.25 EEA19808.1 - 1.1e-39 135.9 0.0 1.3e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19808.1 - 2.3e-23 83.0 0.0 2.8e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19808.1 - 8.7e-10 38.8 0.0 1.2e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA19808.1 - 0.089 12.2 0.0 0.41 10.1 0.0 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EEA19809.1 - 8.1e-34 116.8 0.0 1e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19809.1 - 1.4e-22 80.4 0.0 1.7e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19809.1 - 1e-06 28.8 0.0 1.5e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 KR domain DAO PF01266.24 EEA19810.1 - 6.4e-44 151.0 0.2 7.3e-44 150.8 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA19810.1 - 6.9e-05 22.2 0.1 0.23 10.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA19810.1 - 0.00068 20.2 0.2 0.053 14.1 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA19810.1 - 0.0034 17.6 0.2 0.0076 16.4 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EEA19810.1 - 0.021 14.1 0.3 0.37 10.0 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 EEA19810.1 - 0.1 11.4 0.1 11 4.7 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase SMC_Nse1 PF07574.13 EEA19811.1 - 1.2e-71 240.7 1.1 1.6e-71 240.2 1.1 1.2 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EEA19811.1 - 3.9e-14 52.7 9.6 6.1e-14 52.0 9.6 1.3 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.6 EEA19811.1 - 0.0017 18.6 7.7 0.0027 18.0 7.7 1.3 1 0 0 1 1 1 1 Ring finger domain AbiEi_4 PF13338.6 EEA19811.1 - 0.006 16.7 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator, AbiEi antitoxin DUF2161 PF09929.9 EEA19811.1 - 0.0069 16.5 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 Putative PD-(D/E)XK phosphodiesterase (DUF2161) zf-ANAPC11 PF12861.7 EEA19811.1 - 0.017 15.1 2.3 0.029 14.4 2.3 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FYDLN_acid PF09538.10 EEA19811.1 - 0.05 14.3 2.9 0.098 13.3 2.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-HC5HC2H_2 PF13832.6 EEA19811.1 - 0.17 12.1 2.5 0.38 10.9 2.5 1.6 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EEA19811.1 - 0.44 10.8 6.0 1.3 9.3 6.1 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain FANCL_C PF11793.8 EEA19811.1 - 0.59 10.3 4.3 1.6 9.0 4.2 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EEA19811.1 - 0.68 9.6 4.2 1.1 8.9 4.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EEA19811.1 - 1.6 8.6 6.3 2.8 7.9 6.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA19811.1 - 2.4 8.1 6.5 4.2 7.3 6.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) VlpA_repeat PF04649.12 EEA19811.1 - 7.1 7.1 6.3 61 4.2 0.0 3.6 3 0 0 3 3 3 0 Mycoplasma hyorhinis VlpA repeat CTU2 PF10288.9 EEA19811.1 - 9.6 6.5 8.5 1.1e+02 3.1 8.5 2.5 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Glyco_hydro_65N PF03636.15 EEA19812.1 - 2.8e-32 112.2 0.0 6.2e-32 111.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 EEA19812.1 - 2.2e-23 82.8 5.9 1.9e-18 66.5 1.5 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 EEA19812.1 - 0.00019 21.2 0.1 0.00055 19.8 0.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain F5_F8_type_C PF00754.25 EEA19812.1 - 0.0028 17.8 2.8 0.024 14.8 0.4 3.0 2 0 0 2 2 2 1 F5/8 type C domain F420_oxidored PF03807.17 EEA19812.1 - 0.015 15.8 0.1 8.5 7.0 0.0 3.0 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_S8 PF00082.22 EEA19814.1 - 7.6e-25 87.8 0.0 1.5e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Metallophos PF00149.28 EEA19815.1 - 3.5e-35 122.4 0.1 6.7e-35 121.4 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_10 PF13374.6 EEA19815.1 - 5.1e-18 64.3 0.4 8.6e-12 44.5 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat STPPase_N PF16891.5 EEA19815.1 - 2.4e-13 50.3 1.5 7e-13 48.8 1.5 1.9 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain TPR_12 PF13424.6 EEA19815.1 - 2e-11 44.0 0.0 5.3e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA19815.1 - 1.8e-05 24.5 0.1 0.079 13.0 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat PHD PF00628.29 EEA19815.1 - 0.0002 21.2 12.6 0.00057 19.7 12.6 1.8 1 0 0 1 1 1 1 PHD-finger TPR_17 PF13431.6 EEA19815.1 - 0.019 15.3 0.0 5.1 7.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA19815.1 - 0.13 12.2 0.1 7.5 6.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA19815.1 - 0.14 12.3 0.1 6.1 7.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Prok-RING_1 PF14446.6 EEA19815.1 - 0.35 10.8 11.2 0.49 10.4 9.2 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 EEA19815.1 - 0.36 10.4 6.0 0.91 9.1 6.0 1.7 1 0 0 1 1 1 0 PHD-finger Pyridoxal_deC PF00282.19 EEA19816.1 - 8.2e-102 340.7 0.0 1e-101 340.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EEA19816.1 - 7e-06 25.5 0.0 2.4e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase AAA_22 PF13401.6 EEA19816.1 - 0.11 12.7 0.0 0.35 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Aminotran_1_2 PF00155.21 EEA19816.1 - 0.13 11.4 0.0 0.76 8.9 0.0 2.0 1 1 0 2 2 2 0 Aminotransferase class I and II Cupin_2 PF07883.11 EEA19817.1 - 4.5e-10 39.1 0.0 3e-09 36.5 0.0 2.1 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 EEA19817.1 - 0.0049 16.5 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 EEA19817.1 - 0.018 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 AraC-like ligand binding domain Zn_clus PF00172.18 EEA19818.1 - 4.7e-07 29.8 13.4 9.6e-07 28.8 13.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA19818.1 - 2.8e-05 23.3 0.1 5e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EEA19819.1 - 1.1e-30 106.8 74.4 1.4e-26 93.3 47.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_S28 PF05577.12 EEA19820.1 - 3.7e-49 167.7 3.2 1.8e-40 139.1 0.1 2.4 3 0 0 3 3 3 2 Serine carboxypeptidase S28 HipN PF18253.1 EEA19820.1 - 0.25 11.1 1.2 0.46 10.2 1.2 1.4 1 0 0 1 1 1 0 Hsp70-interacting protein N N-terminal domain Amidohydro_1 PF01979.20 EEA19821.1 - 1.1e-72 245.2 0.0 1.3e-72 245.0 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA19821.1 - 1.7e-11 44.3 0.5 9e-09 35.3 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family tRNA_int_end_N2 PF12928.7 EEA19821.1 - 0.11 12.7 0.0 0.41 10.8 0.0 2.0 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term A_deaminase PF00962.22 EEA19821.1 - 0.18 11.1 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Adenosine/AMP deaminase GDC-P PF02347.16 EEA19822.1 - 1.3e-174 581.1 0.0 4.4e-162 539.8 0.0 2.6 2 1 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 EEA19822.1 - 6.1e-08 32.3 0.5 2.4e-07 30.3 0.2 2.0 2 0 0 2 2 2 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EEA19822.1 - 0.0053 15.3 0.1 0.16 10.4 0.0 2.1 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EEA19822.1 - 0.0085 15.4 0.3 0.024 14.0 0.1 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family MFS_1 PF07690.16 EEA19823.1 - 4.3e-20 71.9 2.1 4.3e-20 71.9 2.1 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19823.1 - 6.1e-12 45.1 1.1 3.7e-10 39.3 0.0 3.1 3 1 0 3 3 3 2 Sugar (and other) transporter Methyltransf_25 PF13649.6 EEA19824.1 - 7.9e-20 71.4 0.0 1.1e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19824.1 - 1.9e-16 60.2 0.0 2.5e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA19824.1 - 5.5e-15 55.8 0.0 8.1e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA19824.1 - 2.3e-11 43.8 0.0 2.8e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA19824.1 - 1.3e-09 38.7 0.0 1.9e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA19824.1 - 2.5e-08 33.5 0.0 3.1e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EEA19824.1 - 6.9e-07 29.2 0.0 8.2e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EEA19824.1 - 7.4e-07 28.9 0.0 9.2e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EEA19824.1 - 4.7e-06 26.1 0.0 4.9e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EEA19824.1 - 0.00031 20.7 0.0 0.00043 20.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EEA19824.1 - 0.00064 19.8 0.0 0.00078 19.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA19824.1 - 0.0028 17.1 0.0 0.0031 17.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EEA19824.1 - 0.0042 16.6 0.0 0.0052 16.3 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase UPF0020 PF01170.18 EEA19824.1 - 0.0073 16.0 0.0 0.15 11.7 0.0 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 RrnaAD PF00398.20 EEA19824.1 - 0.0096 15.0 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase FtsJ PF01728.19 EEA19824.1 - 0.0097 16.0 0.0 0.012 15.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EEA19824.1 - 0.019 14.6 0.0 0.026 14.2 0.0 1.1 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F SepRS_C PF18006.1 EEA19824.1 - 0.054 13.6 0.3 3.4 7.8 0.0 2.4 2 0 0 2 2 2 0 O-phosphoseryl-tRNA synthetase C-terminal domain MetW PF07021.12 EEA19824.1 - 0.062 12.9 0.1 0.088 12.4 0.1 1.4 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW TPMT PF05724.11 EEA19824.1 - 0.068 12.8 0.0 0.078 12.6 0.0 1.1 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_15 PF09445.10 EEA19824.1 - 0.09 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_9 PF08003.11 EEA19824.1 - 0.16 10.8 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CheR PF01739.18 EEA19824.1 - 0.22 11.0 0.0 3.6 7.0 0.0 2.3 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Pentapeptide_4 PF13599.6 EEA19825.1 - 2e-05 24.7 0.6 0.17 12.1 0.0 3.3 2 1 0 2 2 2 2 Pentapeptide repeats (9 copies) CfAFP PF05264.11 EEA19825.1 - 0.57 10.2 15.7 0.77 9.7 5.5 3.0 1 1 2 3 3 3 0 Choristoneura fumiferana antifreeze protein (CfAFP) Zn_clus PF00172.18 EEA19827.1 - 5.6e-07 29.6 7.2 1.2e-06 28.5 7.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_71 PF03659.14 EEA19827.1 - 0.0068 15.3 0.2 0.022 13.6 0.0 1.9 3 0 0 3 3 3 1 Glycosyl hydrolase family 71 FCP1_C PF09309.10 EEA19827.1 - 0.6 9.9 2.9 0.95 9.3 2.9 1.2 1 0 0 1 1 1 0 FCP1, C-terminal AA_permease_2 PF13520.6 EEA19829.1 - 5.7e-87 292.3 40.1 5.7e-87 292.3 40.1 1.3 1 1 0 1 1 1 1 Amino acid permease Glyco_hydro_30 PF02055.16 EEA19831.1 - 3.7e-27 95.2 4.6 2.7e-26 92.4 4.6 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 EEA19831.1 - 3.3e-08 33.6 0.9 9.7e-08 32.1 0.9 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 EEA19831.1 - 0.016 14.4 7.2 0.017 14.3 0.7 2.8 1 1 0 2 2 2 0 Glycosyl hydrolase family 59 tRNA-synt_1c PF00749.21 EEA19832.1 - 3.2e-94 315.4 0.0 4.6e-94 314.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EEA19832.1 - 1e-27 97.2 0.0 3e-27 95.6 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain PseudoU_synth_2 PF00849.22 EEA19832.1 - 0.059 13.5 0.0 14 5.7 0.1 2.4 2 0 0 2 2 2 0 RNA pseudouridylate synthase ThrE PF06738.12 EEA19833.1 - 4.6e-74 248.8 18.9 1.5e-67 227.5 5.5 2.4 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EEA19833.1 - 2.8e-11 43.7 10.1 2.8e-11 43.7 10.1 3.2 2 1 0 2 2 2 1 Threonine/Serine exporter, ThrE AIRS_C PF02769.22 EEA19833.1 - 0.01 15.9 0.3 0.24 11.5 0.1 2.3 1 1 1 2 2 2 0 AIR synthase related protein, C-terminal domain Peptidase_U57 PF05582.12 EEA19833.1 - 0.18 11.0 0.1 2.9 7.1 0.0 2.2 2 0 0 2 2 2 0 YabG peptidase U57 SLT PF01464.20 EEA19834.1 - 0.0034 17.0 0.1 0.012 15.2 0.1 1.8 1 1 0 1 1 1 1 Transglycosylase SLT domain STG PF15809.5 EEA19834.1 - 0.044 13.9 1.2 0.064 13.3 0.1 1.7 1 1 1 2 2 2 0 Simian taste bud-specific gene product family Pectate_lyase_3 PF12708.7 EEA19835.1 - 5.6e-53 180.0 14.4 2e-45 155.3 4.5 2.6 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EEA19835.1 - 0.0042 16.7 2.6 0.14 11.9 0.1 2.8 2 0 0 2 2 2 1 N terminal extension of bacteriophage endosialidase DUF1080 PF06439.11 EEA19835.1 - 0.0094 16.1 1.0 0.16 12.1 0.4 2.3 1 1 1 2 2 2 1 Domain of Unknown Function (DUF1080) Lectin_leg-like PF03388.13 EEA19835.1 - 0.041 13.2 0.1 0.077 12.3 0.1 1.3 1 0 0 1 1 1 0 Legume-like lectin family Herpes_capsid PF06112.11 EEA19835.1 - 4 7.5 8.1 7.7 6.6 8.1 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Sterol_MT_C PF08498.10 EEA19836.1 - 6e-30 103.4 0.8 1e-29 102.6 0.8 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EEA19836.1 - 9.1e-22 77.5 0.0 1.9e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19836.1 - 9.7e-20 71.1 0.0 2.9e-19 69.6 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19836.1 - 2.3e-18 66.5 0.0 3.4e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EEA19836.1 - 2.6e-13 49.9 0.0 3.9e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EEA19836.1 - 6.4e-12 45.6 0.0 1.1e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA19836.1 - 2.5e-10 40.1 0.0 4.1e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EEA19836.1 - 3.6e-09 37.3 0.0 9.3e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EEA19836.1 - 7e-06 24.9 0.0 9.4e-06 24.4 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 EEA19836.1 - 0.00066 19.5 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 EEA19836.1 - 0.0018 17.6 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain PrmA PF06325.13 EEA19836.1 - 0.0021 17.5 0.0 0.0042 16.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 EEA19836.1 - 0.017 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_15 PF09445.10 EEA19836.1 - 0.026 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MTS PF05175.14 EEA19836.1 - 0.033 13.7 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain UPF0020 PF01170.18 EEA19836.1 - 0.047 13.4 0.0 0.1 12.3 0.0 1.7 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 TSC21 PF15217.6 EEA19836.1 - 0.055 13.4 0.1 0.085 12.8 0.1 1.2 1 0 0 1 1 1 0 TSC21 family Methyltransf_32 PF13679.6 EEA19836.1 - 0.062 13.3 0.6 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain TehB PF03848.14 EEA19836.1 - 0.085 12.3 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB RrnaAD PF00398.20 EEA19836.1 - 0.12 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase RRM_1 PF00076.22 EEA19837.1 - 2.4e-08 33.7 0.0 4.1e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA19837.1 - 0.00029 20.6 0.0 0.00049 19.9 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EEA19837.1 - 0.00041 20.3 0.0 0.00068 19.6 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif FoP_duplication PF13865.6 EEA19837.1 - 1.5 9.4 12.0 0.6 10.7 5.1 2.5 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Complex1_LYR PF05347.15 EEA19838.1 - 4.5e-06 26.6 1.9 5.6e-06 26.3 0.4 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) MOSC PF03473.17 EEA19838.1 - 0.0019 18.2 0.1 0.0024 17.9 0.1 1.2 1 0 0 1 1 1 1 MOSC domain Complex1_LYR_2 PF13233.6 EEA19838.1 - 0.16 12.7 1.4 0.21 12.3 1.4 1.4 1 1 0 1 1 1 0 Complex1_LYR-like RAC_head PF16717.5 EEA19839.1 - 1.6e-30 106.0 9.2 1.6e-30 106.0 9.2 3.3 3 1 0 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 EEA19839.1 - 1.4e-18 66.7 3.9 2.2e-18 66.1 1.9 2.5 2 0 0 2 2 2 1 DnaJ domain CemA PF03040.14 EEA19839.1 - 0.8 9.6 5.9 1.7 8.5 5.9 1.5 1 0 0 1 1 1 0 CemA family Aldo_ket_red PF00248.21 EEA19840.1 - 3.1e-69 233.4 0.0 3.5e-69 233.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Phage_tail_X PF05489.12 EEA19840.1 - 0.093 12.4 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Phage Tail Protein X DEAD PF00270.29 EEA19842.1 - 1.5e-16 60.6 0.0 8.3e-16 58.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA19842.1 - 1.2e-10 41.7 0.0 3.8e-10 40.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA19842.1 - 8.3e-07 29.3 0.0 2.9e-06 27.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.16 EEA19842.1 - 0.042 13.3 0.0 0.082 12.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein GH115_C PF17829.1 EEA19842.1 - 0.11 12.4 0.2 0.77 9.6 0.0 2.3 2 0 0 2 2 2 0 Gylcosyl hydrolase family 115 C-terminal domain AChE_tetra PF08674.10 EEA19842.1 - 0.91 9.3 7.9 2.1 8.1 7.9 1.6 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain TFR_dimer PF04253.15 EEA19842.1 - 2.1 8.5 4.4 19 5.3 3.4 2.8 2 0 0 2 2 2 0 Transferrin receptor-like dimerisation domain Methyltransf_2 PF00891.18 EEA19843.1 - 3.8e-28 98.2 0.0 5.7e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EEA19843.1 - 0.00014 21.7 0.0 0.00027 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19843.1 - 0.0039 17.9 0.0 0.011 16.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA19843.1 - 0.0079 15.8 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EEA19843.1 - 0.02 15.6 0.0 0.048 14.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain E1-E2_ATPase PF00122.20 EEA19844.1 - 5.6e-41 140.1 4.0 1.2e-39 135.7 1.6 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EEA19844.1 - 7.8e-38 130.0 1.3 7.8e-38 130.0 1.3 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EEA19844.1 - 1.4e-21 77.8 0.0 6.2e-19 69.1 0.0 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA19844.1 - 5.2e-14 52.1 0.0 9.8e-14 51.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EEA19844.1 - 1.2e-12 47.3 0.1 5e-12 45.3 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EEA19844.1 - 0.0036 17.1 0.0 0.0075 16.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2231 PF09990.9 EEA19844.1 - 0.0065 16.9 1.0 0.032 14.7 1.0 2.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2231) DUF2157 PF09925.9 EEA19844.1 - 0.0091 15.8 6.8 0.016 15.0 0.2 2.9 3 0 0 3 3 3 1 Predicted membrane protein (DUF2157) TMEM43 PF07787.12 EEA19844.1 - 0.59 9.5 4.5 0.42 10.0 0.2 2.4 2 0 0 2 2 2 0 Transmembrane protein 43 bZIP_1 PF00170.21 EEA19845.1 - 6.3e-09 35.8 7.6 1.7e-08 34.4 7.6 1.7 1 1 0 1 1 1 1 bZIP transcription factor ParB PF08775.10 EEA19845.1 - 0.086 13.3 0.3 0.23 11.9 0.3 1.7 1 0 0 1 1 1 0 ParB family bZIP_2 PF07716.15 EEA19845.1 - 0.15 12.2 10.9 9 6.5 9.7 2.8 2 1 0 2 2 2 0 Basic region leucine zipper HALZ PF02183.18 EEA19845.1 - 4 7.7 7.6 0.29 11.4 1.4 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper Actin PF00022.19 EEA19846.1 - 5e-57 193.4 0.0 3.6e-54 183.9 0.0 2.3 1 1 0 1 1 1 1 Actin CorA PF01544.18 EEA19846.1 - 9 5.5 8.5 21 4.3 8.5 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DASH_Dad4 PF08650.10 EEA19847.1 - 1.1e-32 111.8 6.8 1.2e-32 111.7 6.8 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 GM_CSF PF01109.17 EEA19847.1 - 0.0083 16.3 0.5 0.0094 16.1 0.5 1.1 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor DASH_Dad1 PF08649.10 EEA19847.1 - 0.051 13.8 3.8 0.077 13.2 3.8 1.3 1 1 0 1 1 1 0 DASH complex subunit Dad1 YL1_C PF08265.11 EEA19848.1 - 1.5e-14 53.5 0.2 2.4e-14 52.8 0.2 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Complex1_LYR_2 PF13233.6 EEA19849.1 - 0.016 15.9 0.1 0.034 14.9 0.1 1.5 1 0 0 1 1 1 0 Complex1_LYR-like 2OG-FeII_Oxy_3 PF13640.6 EEA19849.1 - 0.029 15.3 0.0 0.054 14.4 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Fungal_trans_2 PF11951.8 EEA19850.1 - 5e-47 160.5 8.1 1.2e-46 159.3 6.4 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain MIS13 PF08202.11 EEA19850.1 - 0.057 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Mis12-Mtw1 protein family Siah-Interact_N PF09032.11 EEA19850.1 - 0.11 12.8 2.5 0.39 11.1 0.1 2.7 3 0 0 3 3 3 0 Siah interacting protein, N terminal Got1 PF04178.12 EEA19851.1 - 6.5e-14 52.3 13.1 8.3e-14 52.0 13.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family AAA PF00004.29 EEA19852.1 - 3.9e-16 59.7 0.0 8.1e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA19852.1 - 0.0031 17.8 1.4 0.11 12.8 1.4 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA19852.1 - 0.0031 17.9 0.0 0.0075 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EEA19852.1 - 0.011 15.8 0.0 0.027 14.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EEA19852.1 - 0.024 14.4 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 EEA19852.1 - 0.028 14.5 0.0 0.068 13.3 0.0 1.6 1 0 0 1 1 1 0 Torsin Drf_FH3 PF06367.16 EEA19852.1 - 0.041 13.5 0.2 0.58 9.8 0.2 2.3 2 0 0 2 2 2 0 Diaphanous FH3 Domain Phage_int_SAM_2 PF12834.7 EEA19852.1 - 0.05 14.3 0.2 0.14 12.8 0.2 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal AAA_19 PF13245.6 EEA19852.1 - 0.059 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EEA19852.1 - 0.065 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 EEA19852.1 - 0.071 13.3 0.1 0.35 11.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain PNP_UDP_1 PF01048.20 EEA19854.1 - 1.7e-11 43.8 0.0 7.9e-11 41.7 0.0 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily Ank_2 PF12796.7 EEA19855.1 - 7.3e-25 87.4 0.2 1.6e-12 47.8 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19855.1 - 1e-23 83.4 1.2 3.7e-09 36.9 0.0 4.2 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19855.1 - 1.1e-21 74.5 2.7 0.00036 20.7 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 EEA19855.1 - 4.8e-20 71.0 2.6 0.0017 18.7 0.0 5.9 5 1 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EEA19855.1 - 2.1e-14 53.4 0.2 1.1e-05 25.6 0.0 4.3 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA19856.1 - 1.1e-38 131.7 8.1 7.6e-11 42.4 0.0 6.2 1 1 6 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19856.1 - 1.9e-28 98.5 2.1 2.6e-06 27.8 0.0 8.6 5 4 5 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19856.1 - 9.5e-27 90.1 2.8 0.0071 16.8 0.0 11.3 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 EEA19856.1 - 1.3e-24 85.5 9.0 0.0033 17.8 0.0 9.7 8 1 1 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EEA19856.1 - 2.7e-20 72.2 3.3 0.0046 17.2 0.0 8.7 4 2 5 9 9 9 6 Ankyrin repeats (many copies) NACHT PF05729.12 EEA19856.1 - 1e-07 32.0 0.0 2.8e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Helo_like_N PF17111.5 EEA19856.1 - 4.9e-06 26.1 0.5 1.4e-05 24.6 0.1 2.0 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins AAA_22 PF13401.6 EEA19856.1 - 2.7e-05 24.4 0.1 0.00011 22.5 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 EEA19856.1 - 0.00014 21.9 1.5 0.17 11.9 0.5 3.5 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA19856.1 - 0.00014 22.2 0.0 0.013 15.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 EEA19856.1 - 0.00015 22.2 0.1 0.001 19.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EEA19856.1 - 0.014 16.0 0.0 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EEA19856.1 - 0.018 14.2 0.1 0.051 12.8 0.1 1.7 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.29 EEA19856.1 - 0.025 15.0 0.0 0.063 13.7 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EEA19856.1 - 0.044 13.8 0.0 0.098 12.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EEA19856.1 - 0.069 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EEA19856.1 - 0.11 12.0 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Profilin PF00235.19 EEA19857.1 - 7.4e-33 113.5 0.1 8.1e-33 113.4 0.1 1.0 1 0 0 1 1 1 1 Profilin DDE_Tnp_1_7 PF13843.6 EEA19858.1 - 9e-50 169.9 0.1 1.3e-49 169.4 0.1 1.2 1 0 0 1 1 1 1 Transposase IS4 Sec63 PF02889.16 EEA19860.1 - 2e-130 433.5 0.2 4.4e-80 268.6 0.1 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EEA19860.1 - 1.2e-51 174.9 0.4 2.4e-26 92.5 0.6 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EEA19860.1 - 6.2e-22 78.4 0.0 8.7e-11 42.1 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA19860.1 - 2.3e-16 60.1 0.0 1.6e-06 28.4 0.0 4.5 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EEA19860.1 - 1.5e-08 35.0 0.3 0.00034 20.9 0.0 3.6 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EEA19860.1 - 7.9e-08 32.2 0.2 0.0042 16.8 0.2 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EEA19860.1 - 4.5e-07 30.3 0.8 0.0041 17.4 0.7 2.9 2 0 0 2 2 2 2 AAA domain Helicase_PWI PF18149.1 EEA19860.1 - 0.0024 18.0 0.0 0.0082 16.3 0.0 1.9 1 0 0 1 1 1 1 N-terminal helicase PWI domain IstB_IS21 PF01695.17 EEA19860.1 - 0.02 14.6 0.1 5.5 6.7 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein TniB PF05621.11 EEA19860.1 - 0.083 12.3 0.3 17 4.7 0.0 3.5 4 0 0 4 4 4 0 Bacterial TniB protein AAA_7 PF12775.7 EEA19860.1 - 0.11 12.0 0.0 13 5.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 EEA19860.1 - 2 8.8 4.2 7.8 6.8 0.0 3.7 4 0 0 4 4 4 0 AAA ATPase domain Synaptobrevin PF00957.21 EEA19861.1 - 2.7e-14 52.7 0.6 5.5e-14 51.7 0.6 1.5 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EEA19861.1 - 4.7e-14 52.2 0.0 9.1e-14 51.3 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain DNA_binding_1 PF01035.20 EEA19862.1 - 7.6e-23 80.4 0.0 1.2e-22 79.8 0.0 1.3 1 1 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain DUF4224 PF13986.6 EEA19862.1 - 0.026 14.4 0.0 4.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) Bud13 PF09736.9 EEA19863.1 - 3.7e-49 166.8 5.3 3.7e-49 166.8 5.3 3.0 3 1 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex Nop16 PF09420.10 EEA19863.1 - 4.4 7.3 16.1 0.43 10.6 7.4 2.4 1 1 1 2 2 2 0 Ribosome biogenesis protein Nop16 Pkinase PF00069.25 EEA19864.1 - 3.8e-40 137.9 0.0 4.5e-22 78.7 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19864.1 - 3.5e-14 52.7 0.2 1.1e-09 38.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA19864.1 - 0.061 12.1 0.3 0.085 11.6 0.3 1.5 1 1 0 1 1 1 0 Fungal protein kinase Ank_2 PF12796.7 EEA19866.1 - 5.9e-16 58.8 0.0 3e-09 37.3 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA19866.1 - 6.3e-12 44.6 0.0 0.03 14.9 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EEA19866.1 - 1e-10 41.6 0.3 0.0019 18.4 0.0 3.9 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA19866.1 - 4e-10 40.0 0.0 5.2e-05 23.7 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA19866.1 - 2.7e-08 33.9 0.2 0.26 11.8 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Pkinase PF00069.25 EEA19867.1 - 9.9e-22 77.6 0.0 3.9e-21 75.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19867.1 - 1.8e-17 63.5 0.0 1.3e-15 57.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EEA19867.1 - 0.042 12.8 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EEA19867.1 - 0.062 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA19867.1 - 0.096 11.4 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Pkinase PF00069.25 EEA19868.1 - 6.4e-07 29.0 0.0 1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA19868.1 - 5.3e-05 22.6 0.0 8.2e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MAT1-1-2 PF17043.5 EEA19868.1 - 0.0098 15.8 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 Mating type protein 1-1-2 of unknown function Metallophos PF00149.28 EEA19869.1 - 2.7e-10 41.1 5.6 1.8e-09 38.4 5.6 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA19869.1 - 3.9e-06 27.2 0.9 4.2e-05 23.8 0.5 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain FMN_dh PF01070.18 EEA19870.1 - 2.2e-125 418.3 0.1 2.7e-125 418.0 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EEA19870.1 - 3.9e-24 84.6 0.0 8.1e-24 83.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EEA19870.1 - 3.7e-08 32.9 0.0 6.3e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EEA19870.1 - 0.00026 20.1 0.0 0.00052 19.1 0.0 1.6 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EEA19870.1 - 0.00052 19.5 0.3 0.0012 18.3 0.1 1.6 2 0 0 2 2 2 1 Nitronate monooxygenase G3P_antiterm PF04309.12 EEA19870.1 - 0.019 14.4 0.0 4.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator His_biosynth PF00977.21 EEA19870.1 - 0.1 12.0 2.3 1.2 8.5 0.2 2.5 2 1 0 3 3 3 0 Histidine biosynthesis protein Ras PF00071.22 EEA19871.1 - 2.8e-40 137.6 0.0 4e-37 127.3 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EEA19871.1 - 2.1e-30 105.4 0.0 3.2e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA19871.1 - 5e-11 42.4 0.0 8.5e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA19871.1 - 8.9e-06 25.8 0.1 1.4e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EEA19871.1 - 0.0043 17.5 0.0 0.007 16.8 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 EEA19871.1 - 0.008 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EEA19871.1 - 0.0083 16.0 0.2 0.02 14.8 0.3 1.7 2 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EEA19871.1 - 0.027 14.7 0.1 0.14 12.4 0.1 2.1 2 1 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 EEA19871.1 - 0.028 13.8 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EEA19871.1 - 0.069 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EEA19871.1 - 0.09 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA_7 PF12775.7 EEA19871.1 - 0.12 11.9 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 EEA19871.1 - 0.17 11.4 0.1 0.29 10.7 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EEA19871.1 - 0.22 11.4 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Glyco_transf_20 PF00982.21 EEA19872.1 - 4.3e-164 546.7 0.0 5e-164 546.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EEA19872.1 - 0.006 16.3 0.1 0.012 15.3 0.0 1.5 2 0 0 2 2 2 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EEA19872.1 - 0.15 11.5 0.3 0.79 9.2 0.0 2.2 3 0 0 3 3 3 0 Glycosyl transferases group 1 adh_short PF00106.25 EEA19873.1 - 2.8e-15 56.3 0.0 5.2e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA19873.1 - 5e-11 42.8 0.1 8.5e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EEA19873.1 - 1.5e-07 31.2 0.1 5.9e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Fungal_trans PF04082.18 EEA19874.1 - 7e-15 54.8 0.1 1.8e-14 53.4 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA19874.1 - 5.6e-06 26.4 12.0 9.3e-06 25.7 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Caroten_synth PF04240.12 EEA19874.1 - 0.038 13.9 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 Carotenoid biosynthesis protein Yip1 PF04893.17 EEA19874.1 - 0.15 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Yip1 domain Myc_N PF01056.18 EEA19874.1 - 8.3 6.2 8.5 0.15 12.0 0.4 2.2 3 0 0 3 3 3 0 Myc amino-terminal region Anoctamin PF04547.12 EEA19875.1 - 1.4e-108 363.7 11.8 1.6e-108 363.4 11.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel MASE1 PF05231.14 EEA19875.1 - 0.021 14.0 5.7 0.043 13.0 5.7 1.4 1 0 0 1 1 1 0 MASE1 MFS_1 PF07690.16 EEA19875.1 - 0.22 10.4 11.6 1.6 7.6 11.6 2.2 1 1 0 1 1 1 0 Major Facilitator Superfamily Brr6_like_C_C PF10104.9 EEA19876.1 - 1.6e-40 138.0 3.1 2e-40 137.6 3.1 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF5542 PF17696.1 EEA19876.1 - 6 7.1 6.7 6.9 6.9 4.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5542) Acetyltransf_1 PF00583.25 EEA19879.1 - 5.5e-15 55.6 0.0 6.9e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EEA19879.1 - 6.7e-08 32.4 0.0 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EEA19879.1 - 1.7e-05 24.8 0.0 2.3e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA19879.1 - 3.1e-05 24.3 0.0 4.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EEA19879.1 - 0.0002 22.1 0.0 0.00024 21.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA19879.1 - 0.029 14.5 0.0 0.16 12.1 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GRIP PF01465.20 EEA19880.1 - 2.1e-16 59.5 0.4 5.1e-16 58.3 0.4 1.7 1 0 0 1 1 1 1 GRIP domain GAS PF13851.6 EEA19880.1 - 8.2e-05 22.0 20.7 8.2e-05 22.0 20.7 10.4 3 2 7 10 10 10 5 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 EEA19880.1 - 0.00065 17.4 53.7 0.00065 17.4 53.7 4.8 3 1 2 5 5 5 2 Protein of unknown function (DUF3584) Spc7 PF08317.11 EEA19880.1 - 0.00067 18.6 165.2 0.0043 16.0 21.9 8.6 2 2 6 8 8 8 6 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 EEA19880.1 - 0.0022 18.2 25.8 0.0022 18.2 25.8 10.0 2 2 7 10 10 8 2 Tropomyosin like CENP-F_leu_zip PF10473.9 EEA19880.1 - 0.0031 17.6 15.8 0.0031 17.6 15.8 10.6 3 2 6 10 10 9 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4763 PF15960.5 EEA19880.1 - 0.0043 16.4 12.6 0.0043 16.4 12.6 7.2 3 2 4 7 7 5 1 Domain of unknown function (DUF4763) Seryl_tRNA_N PF02403.22 EEA19880.1 - 0.0085 16.3 11.9 0.0085 16.3 11.9 12.1 4 3 9 13 13 13 1 Seryl-tRNA synthetase N-terminal domain Cep57_CLD_2 PF14197.6 EEA19880.1 - 0.011 15.7 1.7 0.011 15.7 1.7 12.0 7 2 5 12 12 12 0 Centrosome localisation domain of PPC89 DivIC PF04977.15 EEA19880.1 - 0.018 14.8 0.9 0.018 14.8 0.9 15.7 5 5 12 17 17 17 0 Septum formation initiator Fib_alpha PF08702.10 EEA19880.1 - 0.078 13.2 97.3 0.031 14.5 5.0 9.0 3 1 5 8 8 8 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EEA19880.1 - 0.39 11.1 160.1 1.2 9.5 9.7 8.7 1 1 7 8 8 8 0 Fez1 MARVEL PF01284.23 EEA19881.1 - 1.7e-08 34.6 12.2 2.3e-08 34.2 12.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain FA_hydroxylase PF04116.13 EEA19881.1 - 0.085 13.2 2.8 0.066 13.5 1.3 1.6 1 1 0 1 1 1 0 Fatty acid hydroxylase superfamily RasGAP PF00616.19 EEA19881.1 - 0.1 12.3 0.3 0.16 11.6 0.3 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase DUF2069 PF09842.9 EEA19881.1 - 3.1 8.1 10.4 0.29 11.3 0.8 2.5 2 1 1 3 3 3 0 Predicted membrane protein (DUF2069) MARVEL PF01284.23 EEA19882.1 - 4.9e-08 33.1 7.9 6.2e-08 32.8 7.9 1.1 1 0 0 1 1 1 1 Membrane-associating domain FA_hydroxylase PF04116.13 EEA19882.1 - 0.016 15.6 0.8 0.018 15.4 0.8 1.2 1 0 0 1 1 1 0 Fatty acid hydroxylase superfamily RasGAP PF00616.19 EEA19882.1 - 0.052 13.2 0.2 0.08 12.6 0.2 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase DUF2069 PF09842.9 EEA19882.1 - 0.34 11.1 8.0 0.15 12.3 0.8 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2069) zinc_ribbon_10 PF10058.9 EEA19883.1 - 2.8e-19 68.6 0.1 5e-19 67.8 0.1 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Zip PF02535.22 EEA19883.1 - 0.13 11.4 0.7 3.2 6.9 0.0 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Zn_clus PF00172.18 EEA19884.1 - 3.5e-08 33.4 9.9 7.7e-08 32.3 9.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_pp85 PF04637.12 EEA19884.1 - 0.33 9.3 1.4 0.57 8.5 1.4 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SR-25 PF10500.9 EEA19884.1 - 0.57 9.7 2.5 1.3 8.6 2.5 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein cNMP_binding PF00027.29 EEA19885.1 - 1.2e-28 99.0 0.6 2.7e-17 62.6 0.0 5.6 6 0 0 6 6 6 4 Cyclic nucleotide-binding domain Patatin PF01734.22 EEA19885.1 - 4.2e-17 63.0 7.2 4.2e-12 46.7 2.8 3.4 3 1 0 3 3 3 2 Patatin-like phospholipase Glyco_hydro_1 PF00232.18 EEA19886.1 - 6.3e-73 245.7 1.7 1.6e-70 237.8 1.7 2.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 1 Herpes_UL6 PF01763.16 EEA19886.1 - 0.48 8.9 1.5 2.5 6.5 0.0 2.0 2 0 0 2 2 2 0 Herpesvirus UL6 like RVT_2 PF07727.14 EEA19887.1 - 2.8e-40 138.5 0.0 4.9e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA19887.1 - 4.5e-08 32.8 0.1 1.4e-07 31.2 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA19887.1 - 5.9e-07 29.7 0.1 1.1e-05 25.6 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 EEA19887.1 - 0.00017 21.3 0.8 0.12 12.2 0.0 3.3 2 0 0 2 2 2 2 Integrase core domain Med17 PF10156.9 EEA19888.1 - 3.1e-114 382.3 6.7 5e-114 381.5 6.7 1.3 1 0 0 1 1 1 1 Subunit 17 of Mediator complex ISN1 PF06437.11 EEA19889.1 - 2.7e-197 655.6 0.0 3.1e-197 655.5 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase DUF4646 PF15496.6 EEA19890.1 - 4.5e-09 37.0 0.4 7.2e-08 33.1 0.4 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4646) Erf4 PF10256.9 EEA19890.1 - 0.16 12.1 0.0 1.1 9.4 0.0 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Asp PF00026.23 EEA19893.1 - 2.4e-48 165.2 0.2 2.9e-48 164.9 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EEA19893.1 - 0.0052 16.6 0.0 0.13 12.1 0.0 2.5 2 1 1 3 3 3 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 EEA19893.1 - 0.012 15.8 0.4 1.3 9.2 0.0 2.6 2 1 1 3 3 3 0 Xylanase inhibitor N-terminal BCLP PF12304.8 EEA19893.1 - 0.19 11.3 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Beta-casein like protein adh_short PF00106.25 EEA19894.1 - 3.7e-23 82.0 0.0 7.5e-15 54.9 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19894.1 - 1.6e-22 80.2 0.1 1.1e-14 54.6 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Ligase_CoA PF00549.19 EEA19894.1 - 0.064 13.1 0.0 2.1 8.2 0.0 2.1 2 0 0 2 2 2 0 CoA-ligase Sacchrp_dh_NADP PF03435.18 EEA19894.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Lactamase_B PF00753.27 EEA19895.1 - 2.1e-14 54.0 0.7 4e-14 53.1 0.7 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA19895.1 - 0.0024 17.4 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain N6-adenineMlase PF10237.9 EEA19895.1 - 0.035 13.9 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase DDE_1 PF03184.19 EEA19896.1 - 4.5e-24 85.0 0.0 9.1e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA19896.1 - 8.9e-09 35.3 0.3 3.1e-08 33.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA19896.1 - 0.024 14.8 0.1 0.53 10.5 0.0 2.7 3 0 0 3 3 3 0 Transcription factor Pcc1 Amidase PF01425.21 EEA19896.1 - 0.066 12.2 1.4 0.1 11.6 1.4 1.2 1 0 0 1 1 1 0 Amidase DUF596 PF04591.12 EEA19897.1 - 0.065 13.4 0.5 0.14 12.3 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function, DUF596 PFK PF00365.20 EEA19898.1 - 3.3e-192 637.0 0.7 2e-105 352.2 0.1 2.1 2 0 0 2 2 2 2 Phosphofructokinase DAGK_cat PF00781.24 EEA19898.1 - 0.017 14.7 0.1 0.081 12.6 0.1 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain VSP PF03302.13 EEA19899.1 - 1e-05 24.6 10.1 1.6e-05 24.0 10.1 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.11 EEA19899.1 - 0.00023 21.3 10.5 0.00042 20.5 10.5 1.4 1 0 0 1 1 1 1 Podoplanin DUF4448 PF14610.6 EEA19899.1 - 0.0015 18.3 0.1 0.0023 17.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SKG6 PF08693.10 EEA19899.1 - 0.0049 16.3 2.1 0.0049 16.3 2.1 2.1 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF5585 PF17823.1 EEA19899.1 - 0.025 13.6 33.6 0.032 13.2 33.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Mucin PF01456.17 EEA19899.1 - 0.026 14.5 32.2 0.042 13.8 32.2 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein AJAP1_PANP_C PF15298.6 EEA19899.1 - 0.16 12.1 17.2 0.33 11.2 17.2 1.5 1 0 0 1 1 1 0 AJAP1/PANP C-terminus LapA_dom PF06305.11 EEA19899.1 - 0.66 9.8 2.5 1.5 8.7 0.4 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF2264 PF10022.9 EEA19901.1 - 1.6e-135 451.8 0.2 2e-135 451.5 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Glyco_hydro_76 PF03663.14 EEA19902.1 - 3.6e-162 540.0 19.6 4.3e-162 539.8 19.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EEA19902.1 - 0.022 13.9 11.7 0.29 10.2 0.2 2.9 3 0 0 3 3 3 0 Glycosyl Hydrolase Family 88 RIFIN PF02009.16 EEA19903.1 - 1.7 8.5 2.7 2.3 8.0 2.7 1.2 1 0 0 1 1 1 0 Rifin MIP PF00230.20 EEA19904.1 - 3.5e-46 157.7 14.8 5e-46 157.2 14.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein Orthopox_C10L PF07020.11 EEA19904.1 - 0.32 11.8 8.5 0.24 12.2 6.1 2.0 1 1 1 2 2 2 0 Orthopoxvirus C10L protein Sugar_tr PF00083.24 EEA19905.1 - 5.6e-116 388.1 29.7 1.2e-115 386.9 29.7 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19905.1 - 1.2e-19 70.5 45.2 4.4e-15 55.5 21.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5391 PF17369.2 EEA19905.1 - 1.9 8.5 8.2 1.9 8.6 3.6 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5391) Peptidase_M20 PF01546.28 EEA19906.1 - 8.4e-21 74.6 0.0 1e-20 74.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA19906.1 - 3.1e-05 23.8 0.0 5.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain 2-Hacid_dh_C PF02826.19 EEA19907.1 - 2.8e-41 140.8 0.0 4.6e-41 140.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA19907.1 - 1.5e-10 40.8 0.0 2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA19907.1 - 8.9e-08 32.5 0.0 1.6e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EEA19907.1 - 8.9e-06 26.2 0.0 1.9e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_C PF03720.15 EEA19907.1 - 0.00084 19.7 0.0 0.014 15.8 0.0 2.4 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PDH PF02153.17 EEA19907.1 - 0.0089 15.1 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase DUF4242 PF14026.6 EEA19907.1 - 0.25 11.5 0.9 2.4 8.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4242) REV1_C PF16727.5 EEA19908.1 - 0.081 13.3 3.5 3.6 8.1 0.3 2.5 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA19908.1 - 2.1 8.1 6.1 0.58 9.9 0.2 2.6 3 0 0 3 3 3 0 Sulfotransferase domain NmrA PF05368.13 EEA19909.1 - 5.1e-06 26.2 0.0 0.00019 21.1 0.0 2.8 2 1 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EEA19909.1 - 0.025 14.5 0.0 0.076 12.9 0.0 1.7 1 1 1 2 2 2 0 NAD(P)H-binding RVT_2 PF07727.14 EEA19910.1 - 1.6e-38 132.7 0.2 2.9e-38 131.9 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA19910.1 - 1.3e-05 24.9 0.0 3.5e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_1 PF00078.27 EEA19910.1 - 0.019 14.5 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA19910.1 - 0.064 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA19910.1 - 0.096 13.0 3.2 0.26 11.6 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein Con-6 PF10346.9 EEA19911.1 - 6.4e-20 70.9 2.7 1.8e-10 40.6 0.6 2.3 2 0 0 2 2 2 2 Conidiation protein 6 RTP1_C2 PF10304.9 EEA19911.1 - 0.079 12.7 0.6 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 2 FAM199X PF15814.5 EEA19911.1 - 7.1 5.6 6.9 10 5.1 6.9 1.4 1 0 0 1 1 1 0 Protein family FAM199X DDE_3 PF13358.6 EEA19912.1 - 7.3e-12 45.3 0.2 2.1e-11 43.8 0.2 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA19912.1 - 6.3e-10 39.2 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA19912.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA19912.1 - 0.0077 16.2 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA19912.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA19912.1 - 0.0093 16.4 0.1 13 6.3 0.0 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA19912.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA19912.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA19912.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA19912.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA19912.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 TauD PF02668.16 EEA19913.1 - 4.4e-49 167.7 0.0 5.3e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family COesterase PF00135.28 EEA19914.1 - 3.3e-81 273.7 0.0 4.2e-81 273.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA19914.1 - 3e-05 24.0 0.2 0.16 11.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold ECH_1 PF00378.20 EEA19917.1 - 7.7e-39 133.5 0.0 9.9e-39 133.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA19917.1 - 4.3e-29 102.1 0.0 6.1e-27 95.0 0.0 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Bys1 PF04681.12 EEA19919.1 - 4.5e-10 39.7 0.0 5.3e-10 39.4 0.0 1.0 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Hydrophobin PF01185.18 EEA19921.1 - 3.3e-12 46.9 13.8 4.3e-12 46.5 13.8 1.2 1 0 0 1 1 1 1 Fungal hydrophobin DUF3425 PF11905.8 EEA19922.1 - 1.3e-23 83.3 0.4 2e-23 82.7 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EEA19922.1 - 0.002 18.2 9.9 0.037 14.1 5.3 2.3 2 0 0 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 EEA19922.1 - 0.003 17.6 14.5 0.055 13.6 4.4 2.4 2 0 0 2 2 2 2 Basic region leucine zipper GP120 PF00516.18 EEA19922.1 - 0.19 10.3 0.0 0.26 9.9 0.0 1.1 1 0 0 1 1 1 0 Envelope glycoprotein GP120 MFS_1 PF07690.16 EEA19923.1 - 2.6e-47 161.5 32.7 2.6e-47 161.5 32.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA19923.1 - 1.1e-08 34.4 21.5 5.8e-08 32.0 21.4 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 EEA19923.1 - 0.0028 16.0 1.3 0.0028 16.0 1.3 2.2 3 1 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 EEA19923.1 - 0.31 10.3 19.6 0.01 15.2 10.2 2.6 3 0 0 3 3 3 0 Uncharacterised MFS-type transporter YbfB DUF1445 PF07286.12 EEA19924.1 - 4.9e-34 117.3 0.3 1.5e-16 60.7 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1445) DUF659 PF04937.15 EEA19925.1 - 2.1e-10 40.6 1.0 3.8e-10 39.8 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Dimer_Tnp_hAT PF05699.14 EEA19925.1 - 3.2e-06 26.8 0.1 1.1e-05 25.2 0.1 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2110 PF09883.9 EEA19925.1 - 0.065 12.8 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) APG6_N PF17675.1 EEA19925.1 - 0.23 12.0 6.9 0.87 10.1 6.9 2.0 1 0 0 1 1 1 0 Apg6 coiled-coil region G-alpha PF00503.20 EEA19926.1 - 4.6e-108 361.5 0.2 5.3e-108 361.3 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EEA19926.1 - 1.9e-12 47.0 0.2 5.3e-08 32.5 0.0 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA19926.1 - 1.3e-07 31.3 0.3 0.0002 20.8 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EEA19926.1 - 0.0073 16.5 0.2 2.7 8.2 0.0 3.2 2 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EEA19926.1 - 0.032 13.6 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 EEA19926.1 - 0.04 13.6 0.1 0.097 12.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA19926.1 - 0.066 13.3 0.0 8.4 6.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EEA19926.1 - 0.11 11.8 0.1 0.28 10.5 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF1713 PF08213.11 EEA19927.1 - 2e-10 40.4 19.5 2e-10 40.4 19.5 1.8 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) TT_ORF2 PF02957.15 EEA19927.1 - 4.4 8.3 4.8 2 9.3 0.7 2.4 3 0 0 3 3 3 0 TT viral ORF2 ATP-synt_C PF00137.21 EEA19928.1 - 2.9e-35 120.4 34.6 1.2e-21 76.8 15.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C ATP-synt_C PF00137.21 EEA19929.1 - 1.3e-28 99.1 26.1 5.8e-22 77.8 15.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Tetraspanin PF00335.20 EEA19929.1 - 0.4 10.4 4.1 0.52 10.0 4.1 1.1 1 0 0 1 1 1 0 Tetraspanin family SH PF01445.17 EEA19929.1 - 8.6 6.4 6.8 3.3 7.7 0.3 2.4 3 0 0 3 3 3 0 Viral small hydrophobic protein Pmp3 PF01679.17 EEA19932.1 - 9.7e-25 86.5 8.6 1.1e-24 86.4 8.6 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator CFEM PF05730.11 EEA19933.1 - 0.00029 20.9 7.3 0.0006 19.9 7.3 1.5 1 0 0 1 1 1 1 CFEM domain Stevor PF17410.2 EEA19933.1 - 2.9 7.4 3.3 5.1 6.6 3.3 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Hydrolase_6 PF13344.6 EEA19934.1 - 6.9e-23 80.7 0.0 1.5e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA19934.1 - 1.4e-12 47.4 0.0 1.9e-11 43.9 0.0 2.8 2 1 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EEA19934.1 - 0.088 13.1 0.0 6 7.1 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Lipase_3 PF01764.25 EEA19934.1 - 0.088 12.7 0.0 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 3) BTB PF00651.31 EEA19935.1 - 0.001 19.3 0.0 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF676 PF05057.14 EEA19936.1 - 4.6e-50 170.2 0.0 6.7e-50 169.6 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EEA19936.1 - 9.3e-06 25.6 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 EEA19936.1 - 1.9e-05 25.4 0.0 2.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EEA19936.1 - 0.0023 17.7 0.0 0.0057 16.4 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EEA19936.1 - 0.0025 17.7 0.0 0.0045 16.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Lipase_2 PF01674.18 EEA19936.1 - 0.0097 15.4 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 2) Abhydrolase_1 PF00561.20 EEA19936.1 - 0.18 11.4 0.2 4 7.0 0.1 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold BTK PF00779.19 EEA19937.1 - 2.7 7.9 5.9 0.47 10.3 1.3 2.0 2 0 0 2 2 2 0 BTK motif Ribosomal_L22e PF01776.17 EEA19938.1 - 1.5e-47 160.5 0.2 1.8e-47 160.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Ank_2 PF12796.7 EEA19939.1 - 1.6e-43 147.2 9.0 9.7e-17 61.3 2.0 4.9 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA19939.1 - 3.4e-36 123.2 7.6 2.5e-10 40.7 0.5 6.4 4 1 3 7 7 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA19939.1 - 4.1e-26 90.7 2.1 1.9e-08 34.4 0.0 4.1 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA19939.1 - 1.4e-24 83.5 3.6 0.0006 20.1 0.1 7.8 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 EEA19939.1 - 1.6e-20 72.6 4.7 0.0017 18.7 0.0 6.4 6 0 0 6 6 5 5 Ankyrin repeat PNP_UDP_1 PF01048.20 EEA19939.1 - 4.7e-09 35.9 0.0 9e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 EEA19939.1 - 0.00016 22.1 0.0 0.00073 20.0 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EEA19939.1 - 0.002 18.1 0.0 0.0054 16.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EEA19939.1 - 0.0022 18.2 0.0 0.0089 16.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EEA19939.1 - 0.13 11.4 0.0 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_29 PF13555.6 EEA19939.1 - 0.16 11.8 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 EEA19939.1 - 0.23 11.9 0.3 0.86 10.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase KAP_NTPase PF07693.14 EEA19939.1 - 0.3 10.3 1.6 8.6 5.5 0.4 2.3 1 1 0 2 2 2 0 KAP family P-loop domain Bys1 PF04681.12 EEA19940.1 - 6e-05 23.0 0.1 8.3e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Dynamin_N PF00350.23 EEA19941.1 - 7.9e-05 22.8 0.1 0.00015 21.8 0.1 1.4 2 0 0 2 2 2 1 Dynamin family WD40 PF00400.32 EEA19942.1 - 5e-81 264.5 22.1 4.1e-10 40.1 0.1 13.1 13 0 0 13 13 12 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA19942.1 - 1.3e-41 140.8 0.0 5.6e-05 23.4 0.0 11.8 4 3 8 12 12 12 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA19942.1 - 1e-14 54.2 0.0 0.024 13.6 0.0 6.7 4 3 2 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 EEA19942.1 - 5.5e-14 52.3 0.1 8.5e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 PQQ-like domain Nbas_N PF15492.6 EEA19942.1 - 4e-08 32.9 3.2 0.068 12.5 0.0 7.0 3 3 4 8 8 8 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 EEA19942.1 - 4.7e-08 32.8 1.5 26 4.9 0.0 8.5 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat SGL PF08450.12 EEA19942.1 - 1.2e-06 28.4 0.0 0.014 15.0 0.0 4.8 3 2 1 5 5 5 1 SMP-30/Gluconolactonase/LRE-like region NACHT PF05729.12 EEA19942.1 - 1.2e-06 28.6 0.0 2.6e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 EEA19942.1 - 2.5e-06 26.9 0.1 1.2e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 EEA19942.1 - 2.9e-06 27.8 0.0 2e-05 25.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain Proteasome_A_N PF10584.9 EEA19942.1 - 5e-05 22.9 6.9 6.4 6.5 0.0 6.8 7 0 0 7 7 7 1 Proteasome subunit A N-terminal signature Frtz PF11768.8 EEA19942.1 - 0.00048 18.6 0.0 0.69 8.2 0.0 3.8 4 0 0 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EEA19942.1 - 0.0011 18.4 0.0 8.3 5.6 0.0 4.3 4 1 0 4 4 4 1 WD40-like domain Cytochrom_D1 PF02239.16 EEA19942.1 - 0.0013 17.3 0.0 0.62 8.5 0.0 3.2 3 0 0 3 3 3 1 Cytochrome D1 heme domain APS_kinase PF01583.20 EEA19942.1 - 0.0078 16.1 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 EEA19942.1 - 0.16 11.7 0.0 0.39 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain K1 PF02960.14 EEA19942.1 - 0.17 12.0 0.2 0.36 10.9 0.2 1.5 1 0 0 1 1 1 0 K1 glycoprotein KAP_NTPase PF07693.14 EEA19942.1 - 0.18 11.0 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain Pro-kuma_activ PF09286.11 EEA19943.1 - 2.4e-47 160.8 0.0 5.8e-47 159.6 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EEA19943.1 - 0.00015 21.2 0.3 0.00028 20.2 0.3 1.4 1 0 0 1 1 1 1 Subtilase family SecD-TM1 PF13721.6 EEA19943.1 - 0.1 13.0 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 SecD export protein N-terminal TM region Ribonucleas_3_3 PF14622.6 EEA19944.1 - 4.2e-07 30.2 0.0 5.8e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EEA19944.1 - 1.9e-05 25.3 0.0 8.6e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease III domain IBR PF01485.21 EEA19945.1 - 1.3e-12 47.7 18.4 3.7e-11 43.1 1.0 3.6 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EEA19945.1 - 0.0019 18.0 7.1 0.0019 18.0 7.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DNA_RNApol_7kD PF03604.13 EEA19945.1 - 0.025 14.3 8.8 3.8 7.3 5.7 3.3 2 1 1 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Sgf11 PF08209.11 EEA19945.1 - 0.2 11.3 0.1 0.2 11.3 0.1 3.6 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) zf-ISL3 PF14690.6 EEA19945.1 - 1.2 9.9 8.0 9.8 6.9 0.8 3.5 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 TRAF6_Z2 PF18048.1 EEA19945.1 - 1.2 9.3 6.6 0.74 10.0 0.3 2.6 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 UPF0547 PF10571.9 EEA19945.1 - 3.1 8.0 10.5 5.3 7.2 1.9 3.3 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 DUF3280 PF11684.8 EEA19945.1 - 3.6 8.0 12.3 0.11 12.9 4.6 2.4 2 2 0 2 2 2 0 Protein of unknown function (DUF2380) zf-RING_7 PF02591.15 EEA19945.1 - 4.6 7.5 11.0 2.2 8.5 0.7 3.7 3 0 0 3 3 3 0 C4-type zinc ribbon domain zf-UDP PF14569.6 EEA19945.1 - 5.3 7.2 14.2 3.1 8.0 1.0 3.7 3 1 0 3 3 3 0 Zinc-binding RING-finger RR_TM4-6 PF06459.12 EEA19945.1 - 6.6 6.5 16.5 12 5.6 16.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HSP70 PF00012.20 EEA19947.1 - 5.2e-09 34.8 0.0 3.7e-08 32.0 0.0 1.9 1 1 1 2 2 2 1 Hsp70 protein BcrAD_BadFG PF01869.20 EEA19947.1 - 0.00027 20.5 0.0 0.0027 17.2 0.0 2.1 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family MreB_Mbl PF06723.13 EEA19947.1 - 0.026 13.4 0.0 0.36 9.6 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein Peptidase_M22 PF00814.25 EEA19947.1 - 0.12 12.0 0.0 0.44 10.2 0.0 1.7 2 0 0 2 2 2 0 Glycoprotease family PhyH PF05721.13 EEA19948.1 - 0.002 18.4 0.0 0.0028 18.0 0.0 1.4 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EEA19948.1 - 0.049 12.4 0.0 0.43 9.3 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1479) PNP_UDP_1 PF01048.20 EEA19949.1 - 6.3e-13 48.5 0.0 1.9e-12 46.9 0.0 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.6 EEA19950.1 - 0.0082 16.4 0.0 1.2 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA19950.1 - 0.017 15.5 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EEA19950.1 - 0.044 13.1 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF87 PF01935.17 EEA19950.1 - 0.05 13.7 0.0 11 6.0 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EEA19950.1 - 0.08 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family dsrm PF00035.26 EEA19951.1 - 0.00054 20.6 0.0 0.00092 19.9 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif OTT_1508_deam PF14441.6 EEA19952.1 - 3.7e-20 71.7 3.7 1e-19 70.3 3.7 1.8 1 0 0 1 1 1 1 OTT_1508-like deaminase TMF_DNA_bd PF12329.8 EEA19954.1 - 0.022 14.8 3.7 0.052 13.5 3.7 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Translin PF01997.16 EEA19956.1 - 5.3e-51 173.5 0.1 6.6e-51 173.2 0.1 1.0 1 0 0 1 1 1 1 Translin family GMP_synt_C PF00958.22 EEA19956.1 - 0.098 12.7 0.0 0.57 10.3 0.0 2.0 2 0 0 2 2 2 0 GMP synthase C terminal domain GSHPx PF00255.19 EEA19957.1 - 4.7e-39 132.3 0.0 7.1e-39 131.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EEA19957.1 - 0.00047 20.1 0.0 0.00093 19.1 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EEA19957.1 - 0.086 12.5 0.1 0.14 11.8 0.0 1.5 2 0 0 2 2 2 0 Redoxin Pcc1 PF09341.10 EEA19958.1 - 1.7e-30 105.0 0.2 2.1e-30 104.7 0.2 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 DSPn PF14671.6 EEA19959.1 - 5.1e-43 146.9 0.0 1.7e-40 138.7 0.0 2.5 2 1 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EEA19959.1 - 6.2e-16 58.4 0.1 1.6e-15 57.1 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA19959.1 - 3.4e-06 26.8 0.0 5.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EEA19959.1 - 0.17 11.5 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Glyco_hydro_31 PF01055.26 EEA19961.1 - 3.3e-146 487.9 8.1 4.6e-146 487.5 8.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EEA19961.1 - 1.2e-37 128.7 0.1 2e-37 127.9 0.1 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EEA19961.1 - 1.2e-10 41.6 0.4 5.1e-10 39.5 0.4 2.2 1 0 0 1 1 1 1 Galactose mutarotase-like AMP_N PF05195.16 EEA19961.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Aminopeptidase P, N-terminal domain Peptidase_S10 PF00450.22 EEA19962.1 - 1.7e-77 261.6 0.4 2.3e-77 261.2 0.4 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Tautomerase_3 PF14832.6 EEA19963.1 - 1.2e-47 161.5 0.0 1.4e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme DUF3112 PF11309.8 EEA19964.1 - 3e-17 62.8 10.2 2.7e-10 40.1 0.8 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) MFS_1 PF07690.16 EEA19965.1 - 3.7e-35 121.5 34.4 4.9e-35 121.1 34.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA19965.1 - 6e-09 34.9 14.8 1.3e-07 30.5 5.3 2.4 3 0 0 3 3 3 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA19965.1 - 3.3e-08 32.8 9.8 3.3e-08 32.8 9.8 3.1 3 1 0 3 3 3 2 Sugar (and other) transporter ATP-synt_Z PF16594.5 EEA19965.1 - 0.027 14.0 2.2 2.2 7.8 0.0 3.5 3 0 0 3 3 3 0 Putative AtpZ or ATP-synthase-associated DUF4418 PF14387.6 EEA19965.1 - 1.8 8.8 6.8 2 8.6 0.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4418) DUF2637 PF10935.8 EEA19966.1 - 0.046 13.6 0.5 0.083 12.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) Glyco_hydro_18 PF00704.28 EEA19967.1 - 7.9e-21 75.1 2.1 3.1e-20 73.1 2.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Sugar_tr PF00083.24 EEA19968.1 - 2.2e-88 297.1 18.5 2.6e-88 296.9 18.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA19968.1 - 1.3e-16 60.5 28.0 4.3e-16 58.8 22.2 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily Methyltransf_2 PF00891.18 EEA19969.1 - 1.4e-19 70.2 0.0 2.8e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EEA19969.1 - 0.017 14.9 0.0 0.062 13.1 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Sigma70_r4 PF04545.16 EEA19969.1 - 0.024 14.2 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 CheR PF01739.18 EEA19969.1 - 0.094 12.2 0.0 0.67 9.4 0.0 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Sigma70_r3 PF04539.16 EEA19969.1 - 0.18 11.9 0.0 2.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-70 region 3 FAD_binding_4 PF01565.23 EEA19970.1 - 8.7e-06 25.5 2.4 1.6e-05 24.6 2.4 1.5 1 0 0 1 1 1 1 FAD binding domain RdRP_3 PF00998.23 EEA19970.1 - 0.26 10.0 0.1 0.33 9.6 0.1 1.1 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase Abhydrolase_2 PF02230.16 EEA19972.1 - 1e-08 35.2 0.0 1.8e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase MFS_1 PF07690.16 EEA19973.1 - 1.2e-35 123.1 51.7 1.8e-32 112.7 29.5 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily ATG22 PF11700.8 EEA19973.1 - 0.00081 18.1 20.4 0.058 12.0 11.6 2.4 1 1 1 2 2 2 2 Vacuole effluxer Atg22 like Pox_A14 PF05767.12 EEA19973.1 - 0.0016 18.6 0.7 0.0016 18.6 0.7 2.1 2 0 0 2 2 2 1 Poxvirus virion envelope protein A14 FliG_N PF14842.6 EEA19973.1 - 0.0077 16.8 0.0 0.013 16.0 0.0 1.3 1 0 0 1 1 1 1 FliG N-terminal domain LapA_dom PF06305.11 EEA19973.1 - 0.097 12.5 1.2 0.98 9.3 0.2 3.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Glyco_hydro_cc PF11790.8 EEA19974.1 - 1e-55 188.9 3.7 1.2e-55 188.7 3.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_72 PF03198.14 EEA19974.1 - 0.06 12.6 2.4 0.092 12.0 2.4 1.2 1 0 0 1 1 1 0 Glucanosyltransferase adh_short PF00106.25 EEA19976.1 - 2.5e-34 118.5 0.1 3.4e-34 118.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19976.1 - 7.3e-24 84.6 0.0 1.1e-23 84.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA19976.1 - 1.7e-11 44.4 0.4 8.8e-10 38.8 0.4 2.2 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA19976.1 - 0.00025 20.6 0.1 0.00046 19.7 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family p450 PF00067.22 EEA19977.1 - 2.4e-75 254.1 0.0 3e-75 253.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SDH_sah PF01972.16 EEA19977.1 - 0.13 11.2 0.0 0.24 10.3 0.0 1.5 1 0 0 1 1 1 0 Serine dehydrogenase proteinase p450 PF00067.22 EEA19978.1 - 1.6e-72 244.8 0.0 1.9e-72 244.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 polyprenyl_synt PF00348.17 EEA19979.1 - 3.6e-64 216.3 0.0 7.7e-64 215.2 0.0 1.6 2 0 0 2 2 2 1 Polyprenyl synthetase Prenyltrans PF00432.21 EEA19979.1 - 0.0013 18.4 0.3 0.027 14.2 0.0 3.0 3 0 0 3 3 3 1 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EEA19979.1 - 0.04 13.0 0.0 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain Y_phosphatase3 PF13350.6 EEA19980.1 - 4.8e-51 174.0 0.0 1.5e-50 172.3 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EEA19980.1 - 4.5e-05 23.1 0.0 0.00068 19.2 0.0 2.1 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EEA19980.1 - 0.00052 19.6 0.0 0.0019 17.8 0.0 1.8 1 1 1 2 2 2 1 Protein-tyrosine phosphatase RapA_C PF12137.8 EEA19980.1 - 0.16 11.0 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal DUF2492 PF10678.9 EEA19980.1 - 0.19 12.1 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2492) Aldedh PF00171.22 EEA19981.1 - 1.1e-77 261.5 0.0 1.3e-77 261.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family p450 PF00067.22 EEA19982.1 - 4.6e-46 157.5 0.0 6.4e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 EEA19982.1 - 1.3e-05 25.1 0.0 2.7e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA19982.1 - 0.0003 20.6 0.0 0.0011 18.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA19982.1 - 0.00032 21.3 0.0 0.0015 19.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Fungal_trans_2 PF11951.8 EEA19985.1 - 2.1e-05 23.5 0.0 5e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 EEA19986.1 - 4.1e-18 65.8 0.0 4.5e-18 65.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA19986.1 - 9.2e-09 35.0 0.0 1.3e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase DDE_1 PF03184.19 EEA19987.1 - 7.5e-24 84.3 0.0 1.4e-23 83.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease adh_short PF00106.25 EEA19987.1 - 6.9e-18 64.8 1.5 1.3e-17 63.9 1.5 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA19987.1 - 1.8e-16 60.4 0.9 4.1e-16 59.3 0.9 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase HTH_Tnp_Tc5 PF03221.16 EEA19987.1 - 1.2e-08 34.8 0.3 4.1e-08 33.1 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA19987.1 - 0.013 15.6 0.1 0.22 11.7 0.0 2.6 3 0 0 3 3 3 0 Transcription factor Pcc1 Amidase PF01425.21 EEA19987.1 - 0.071 12.1 1.6 0.11 11.4 1.6 1.2 1 0 0 1 1 1 0 Amidase AdoHcyase_NAD PF00670.21 EEA19987.1 - 0.25 11.4 2.6 0.32 11.0 0.6 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FAD_binding_3 PF01494.19 EEA19988.1 - 1.7e-05 24.2 3.2 0.041 13.1 1.2 2.3 1 1 1 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA19988.1 - 3.1e-05 24.1 0.5 8.7e-05 22.7 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA19988.1 - 0.00035 20.3 0.7 0.00064 19.4 0.7 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA19988.1 - 0.00061 19.1 1.0 0.0011 18.2 0.7 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA19988.1 - 0.00073 19.5 0.3 0.0032 17.4 0.3 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EEA19988.1 - 0.012 14.3 0.4 0.02 13.6 0.4 1.3 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EEA19988.1 - 0.022 13.6 0.9 0.065 12.1 0.5 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 EEA19988.1 - 0.041 14.5 0.5 0.086 13.4 0.5 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA19988.1 - 0.043 13.1 0.2 0.073 12.3 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RVT_2 PF07727.14 EEA19990.1 - 9.2e-11 41.8 0.0 1.6e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA19990.1 - 1.5e-07 31.6 0.3 5.6e-06 26.5 0.0 3.0 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 EEA19990.1 - 0.00022 21.0 0.2 0.00073 19.3 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA19990.1 - 0.13 12.4 0.0 0.74 10.0 0.0 2.3 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Integrase_H2C2 PF17921.1 EEA19990.1 - 0.8 9.9 8.7 0.46 10.6 0.1 3.6 3 0 0 3 3 3 0 Integrase zinc binding domain DUF2353 PF09789.9 EEA19991.1 - 0.00068 19.1 2.5 0.00068 19.1 2.5 1.8 2 0 0 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) HALZ PF02183.18 EEA19991.1 - 0.0022 18.2 4.9 0.0076 16.5 4.9 1.9 1 0 0 1 1 1 1 Homeobox associated leucine zipper Retrotran_gag_2 PF14223.6 EEA19991.1 - 0.0029 17.3 0.7 0.0029 17.3 0.7 2.5 2 1 0 2 2 2 1 gag-polypeptide of LTR copia-type Retrotrans_gag PF03732.17 EEA19991.1 - 0.021 15.1 8.2 0.2 11.9 0.2 2.6 2 1 1 3 3 3 0 Retrotransposon gag protein VP9 PF09625.10 EEA19991.1 - 0.076 13.2 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 VP9 protein FtsL PF04999.13 EEA19991.1 - 0.13 12.3 3.2 0.3 11.1 3.2 1.6 1 0 0 1 1 1 0 Cell division protein FtsL DASH_Dam1 PF08653.10 EEA19991.1 - 0.2 11.5 2.0 0.43 10.4 0.5 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 Spc24 PF08286.11 EEA19991.1 - 0.27 11.5 5.0 1.2 9.5 1.4 2.5 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4337 PF14235.6 EEA19991.1 - 0.3 11.2 2.9 0.67 10.0 2.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) PRKG1_interact PF15898.5 EEA19991.1 - 0.66 10.9 10.1 0.11 13.4 3.4 2.6 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 EEA19991.1 - 0.79 9.5 5.0 2.1 8.2 5.0 1.8 1 0 0 1 1 1 0 Septum formation initiator TetR PF13972.6 EEA19991.1 - 1.1 9.0 8.1 0.75 9.5 4.0 2.2 2 0 0 2 2 2 0 Bacterial transcriptional repressor V_ATPase_I PF01496.19 EEA19991.1 - 1.5 6.7 6.8 0.074 11.0 1.2 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family HIP1_clath_bdg PF16515.5 EEA19991.1 - 2.7 8.7 11.6 0.59 10.8 6.3 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0242 PF06785.11 EEA19991.1 - 5.2 7.1 14.4 0.33 11.0 6.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Takusan PF04822.13 EEA19991.1 - 5.5 6.9 10.1 6.7 6.7 3.5 3.6 2 2 2 4 4 4 0 Takusan RT_RNaseH PF17917.1 EEA19992.1 - 5.2e-33 113.5 0.1 1.1e-32 112.4 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EEA19992.1 - 7.1e-33 112.6 0.0 1.6e-32 111.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EEA19992.1 - 8.9e-30 103.9 0.0 1.5e-29 103.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EEA19992.1 - 3.4e-14 52.7 0.4 7.5e-14 51.6 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EEA19992.1 - 1.5e-13 51.0 0.0 3.4e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EEA19992.1 - 0.017 15.3 0.0 0.046 13.9 0.0 1.8 1 0 0 1 1 1 0 H2C2 zinc finger RVP_2 PF08284.11 EEA19992.1 - 0.086 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-RVT PF13966.6 EEA19993.1 - 0.0024 18.5 0.3 0.0039 17.9 0.3 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase zf-RRPl_C4 PF17026.5 EEA19993.1 - 0.066 13.3 0.1 0.085 13.0 0.1 1.1 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Exo_endo_phos_2 PF14529.6 EEA19994.1 - 4e-11 42.8 0.1 1e-10 41.4 0.1 1.8 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase DUF16 PF01519.16 EEA19994.1 - 0.00099 19.6 5.7 0.0023 18.4 5.7 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF16 Fib_alpha PF08702.10 EEA19994.1 - 0.0027 17.9 5.4 0.0046 17.2 5.4 1.3 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Dynactin_p22 PF07426.11 EEA19994.1 - 0.024 14.5 2.9 0.039 13.8 2.9 1.3 1 0 0 1 1 1 0 Dynactin subunit p22 Phage_GPO PF05929.11 EEA19994.1 - 0.048 13.3 2.7 0.56 9.8 2.8 2.0 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase SlyX PF04102.12 EEA19994.1 - 0.18 12.4 3.6 0.6 10.8 3.6 2.0 1 1 0 1 1 1 0 SlyX BLOC1_2 PF10046.9 EEA19994.1 - 0.33 11.3 3.8 0.72 10.2 3.8 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAM76 PF16046.5 EEA19994.1 - 0.5 9.7 3.3 0.77 9.1 3.3 1.2 1 0 0 1 1 1 0 FAM76 protein GlutR_dimer PF00745.20 EEA19994.1 - 3.7 8.1 6.6 6.5 7.3 1.9 2.9 1 1 2 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain APH PF01636.23 EEA19995.1 - 6.7e-09 36.0 0.0 1.1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA19995.1 - 0.00094 18.8 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EEA19995.1 - 0.023 14.1 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MASE3 PF17159.4 EEA19995.1 - 0.13 11.8 0.1 0.19 11.3 0.1 1.1 1 0 0 1 1 1 0 Membrane-associated sensor domain E2F_CC-MB PF16421.5 EEA19998.1 - 0.71 10.3 6.9 3.9 7.9 0.2 2.4 2 1 0 2 2 2 0 E2F transcription factor CC-MB domain adh_short_C2 PF13561.6 EEA19999.1 - 4e-37 128.0 0.2 6.9e-37 127.2 0.2 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA19999.1 - 2.8e-35 121.5 0.0 4.1e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase DDE_3 PF13358.6 EEA19999.1 - 1.7e-10 40.8 0.0 3.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease KR PF08659.10 EEA19999.1 - 5.1e-07 29.8 1.4 2e-06 27.8 0.1 2.1 2 0 0 2 2 2 1 KR domain ADH_zinc_N PF00107.26 EEA19999.1 - 0.012 15.6 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF1776 PF08643.10 EEA19999.1 - 0.014 14.8 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) HTH_32 PF13565.6 EEA19999.1 - 0.027 15.1 0.4 0.095 13.3 0.1 2.1 1 1 1 2 2 2 0 Homeodomain-like domain 3HCDH_N PF02737.18 EEA19999.1 - 0.035 14.0 0.1 0.07 13.0 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EEA19999.1 - 0.21 10.7 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein p450 PF00067.22 EEA20000.1 - 1.8e-35 122.6 0.1 2.6e-20 72.6 0.1 2.1 1 1 1 2 2 2 2 Cytochrome P450 Amidohydro_1 PF01979.20 EEA20001.1 - 1.1e-29 103.9 0.5 6.5e-29 101.3 0.5 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA20001.1 - 4.8e-11 42.8 2.6 3.5e-06 26.8 0.3 2.6 1 1 1 2 2 2 2 Amidohydrolase family MFS_1 PF07690.16 EEA20002.1 - 1.2e-15 57.4 8.4 1.2e-15 57.3 8.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20002.1 - 7.8e-06 25.0 5.8 9.4e-06 24.7 5.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EEA20002.1 - 0.0056 15.6 3.3 0.0062 15.4 3.3 1.0 1 0 0 1 1 1 1 MFS_1 like family MFS_2 PF13347.6 EEA20002.1 - 0.054 12.0 3.7 0.061 11.9 3.7 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein L6_membrane PF05805.12 EEA20002.1 - 0.1 12.1 2.2 0.12 11.9 2.2 1.2 1 0 0 1 1 1 0 L6 membrane protein Spore_III_AF PF09581.10 EEA20002.1 - 0.18 11.9 0.1 0.22 11.6 0.1 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Pyr_redox_3 PF13738.6 EEA20003.1 - 1.9e-17 63.5 0.0 3.4e-16 59.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EEA20003.1 - 9.9e-13 47.3 0.0 7.6e-12 44.4 0.0 2.0 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EEA20003.1 - 1e-11 44.6 0.0 6.6e-11 41.9 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EEA20003.1 - 4.3e-08 32.8 0.0 3.1e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA20003.1 - 2.6e-05 24.0 0.0 0.00028 20.6 0.0 2.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA20003.1 - 0.026 15.1 0.1 0.58 10.8 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA20003.1 - 0.041 13.9 0.0 11 6.0 0.0 2.7 2 1 0 2 2 2 0 FAD-NAD(P)-binding Zn_clus PF00172.18 EEA20004.1 - 3.5e-06 27.0 10.6 7.4e-06 26.0 10.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA20004.1 - 6e-06 25.5 0.0 1.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_cc PF11790.8 EEA20004.1 - 0.044 13.3 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core adh_short_C2 PF13561.6 EEA20005.1 - 3.1e-57 193.9 0.0 3.7e-57 193.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA20005.1 - 7.2e-47 159.4 0.0 9.4e-47 159.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA20005.1 - 6.6e-14 52.2 0.0 9.9e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 KR domain HATPase_c PF02518.26 EEA20005.1 - 0.002 18.6 0.0 0.0043 17.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 3Beta_HSD PF01073.19 EEA20005.1 - 0.032 13.3 0.0 0.065 12.2 0.0 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF43 PF01861.16 EEA20005.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Helicase_C PF00271.31 EEA20006.1 - 2.7e-07 30.9 0.1 4e-07 30.4 0.1 1.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Nup54 PF13874.6 EEA20007.1 - 0.0024 18.0 5.8 0.0037 17.4 5.8 1.3 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 V_ATPase_I PF01496.19 EEA20007.1 - 0.18 9.7 0.9 0.19 9.6 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 EEA20007.1 - 0.38 9.6 7.9 0.5 9.2 7.9 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein TipAS PF07739.13 EEA20007.1 - 1.3 9.6 4.9 4.1 8.0 1.2 2.3 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain DMPK_coil PF08826.10 EEA20007.1 - 3.1 8.0 11.3 0.35 11.0 5.7 2.0 2 0 0 2 2 2 0 DMPK coiled coil domain like Nup54 PF13874.6 EEA20008.1 - 0.0024 18.0 5.8 0.0037 17.4 5.8 1.3 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 V_ATPase_I PF01496.19 EEA20008.1 - 0.18 9.7 0.9 0.19 9.6 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 EEA20008.1 - 0.38 9.6 7.9 0.5 9.2 7.9 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein TipAS PF07739.13 EEA20008.1 - 1.3 9.6 4.9 4.1 8.0 1.2 2.3 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain DMPK_coil PF08826.10 EEA20008.1 - 3.1 8.0 11.3 0.35 11.0 5.7 2.0 2 0 0 2 2 2 0 DMPK coiled coil domain like Nup54 PF13874.6 EEA20009.1 - 0.0024 18.0 5.8 0.0037 17.4 5.8 1.3 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 V_ATPase_I PF01496.19 EEA20009.1 - 0.18 9.7 0.9 0.19 9.6 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 EEA20009.1 - 0.38 9.6 7.9 0.5 9.2 7.9 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein TipAS PF07739.13 EEA20009.1 - 1.3 9.6 4.9 4.1 8.0 1.2 2.3 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain DMPK_coil PF08826.10 EEA20009.1 - 3.1 8.0 11.3 0.35 11.0 5.7 2.0 2 0 0 2 2 2 0 DMPK coiled coil domain like HsbA PF12296.8 EEA20010.1 - 3.4e-15 56.5 0.0 5.1e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A HsbA PF12296.8 EEA20012.1 - 7.7e-19 68.3 0.3 1.1e-18 67.8 0.3 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A Dimer_Tnp_Tn5 PF02281.16 EEA20012.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Transposase Tn5 dimerisation domain OrsD PF12013.8 EEA20013.1 - 6.6e-10 39.4 0.2 2e-09 37.9 0.2 1.8 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_12 PF18658.1 EEA20013.1 - 0.0079 15.8 0.0 0.11 12.1 0.0 2.5 2 0 0 2 2 2 1 Zinc-finger C2H2-type zf-BED PF02892.15 EEA20013.1 - 0.033 14.2 2.9 0.056 13.5 0.9 2.5 2 0 0 2 2 2 0 BED zinc finger AF-4 PF05110.13 EEA20014.1 - 0.024 12.8 20.3 0.033 12.3 20.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CDC45 PF02724.14 EEA20014.1 - 0.1 10.9 1.7 0.12 10.6 1.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EEA20014.1 - 0.17 11.3 4.2 0.21 11.0 4.2 1.1 1 0 0 1 1 1 0 SDA1 CCDC106 PF15794.5 EEA20014.1 - 3.1 7.5 5.0 4.5 6.9 5.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Nop14 PF04147.12 EEA20014.1 - 4.6 5.3 6.5 5.8 5.0 6.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF3435 PF11917.8 EEA20016.1 - 1.4e-07 30.8 0.2 1.8e-07 30.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-Sec23_Sec24 PF04810.15 EEA20016.1 - 0.11 12.5 0.6 0.24 11.5 0.6 1.6 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Acetyltransf_1 PF00583.25 EEA20017.1 - 2.7e-11 43.7 0.0 4.9e-11 42.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA20017.1 - 3.1e-11 43.3 0.0 1.1e-10 41.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA20017.1 - 1.5e-09 38.1 0.0 3.7e-09 36.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA20017.1 - 0.00038 20.5 0.0 0.00076 19.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA20017.1 - 0.00099 19.0 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EEA20017.1 - 0.0044 17.1 0.0 0.0083 16.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 EEA20018.1 - 2.7e-11 43.7 0.0 4.9e-11 42.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA20018.1 - 3.1e-11 43.3 0.0 1.1e-10 41.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA20018.1 - 1.5e-09 38.1 0.0 3.7e-09 36.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA20018.1 - 0.00038 20.5 0.0 0.00076 19.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA20018.1 - 0.00099 19.0 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EEA20018.1 - 0.0044 17.1 0.0 0.0083 16.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 EEA20019.1 - 2.7e-11 43.7 0.0 4.9e-11 42.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA20019.1 - 3.1e-11 43.3 0.0 1.1e-10 41.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA20019.1 - 1.5e-09 38.1 0.0 3.7e-09 36.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA20019.1 - 0.00038 20.5 0.0 0.00076 19.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA20019.1 - 0.00099 19.0 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EEA20019.1 - 0.0044 17.1 0.0 0.0083 16.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase BCS1_N PF08740.11 EEA20022.1 - 5.6e-32 111.2 0.1 1.1e-31 110.3 0.1 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EEA20022.1 - 6.3e-16 59.0 0.0 1.2e-15 58.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 EEA20022.1 - 0.058 13.1 0.4 0.32 10.7 0.0 2.3 3 0 0 3 3 3 0 Cytidylate kinase ATPase PF06745.13 EEA20022.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_17 PF13207.6 EEA20022.1 - 0.15 12.4 0.1 2.5 8.5 0.1 2.4 1 1 0 1 1 1 0 AAA domain FemAB PF02388.16 EEA20023.1 - 0.015 14.2 5.5 0.016 14.1 5.5 1.0 1 0 0 1 1 1 0 FemAB family GBP_C PF02841.14 EEA20023.1 - 0.1 12.0 16.5 0.1 12.0 16.5 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain ARGLU PF15346.6 EEA20023.1 - 0.19 11.6 27.2 0.2 11.5 27.2 1.0 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 MRP-S26 PF14943.6 EEA20023.1 - 0.35 10.8 17.4 0.38 10.7 17.4 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Borrelia_P83 PF05262.11 EEA20023.1 - 0.51 8.8 10.5 0.53 8.7 10.5 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein MAS20 PF02064.15 EEA20023.1 - 1.2 9.2 11.9 1.3 9.1 11.9 1.1 1 0 0 1 1 1 0 MAS20 protein import receptor U79_P34 PF03064.16 EEA20023.1 - 1.5 8.1 13.8 1.6 8.0 13.8 1.0 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Vfa1 PF08432.10 EEA20023.1 - 1.5 9.1 10.1 1.5 9.1 10.1 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4637 PF15470.6 EEA20023.1 - 2 8.1 13.2 2.1 8.1 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) GNAT_acetyltr_2 PF13718.6 EEA20023.1 - 2.4 7.5 6.2 2.4 7.5 6.2 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DDRGK PF09756.9 EEA20023.1 - 2.5 7.6 22.2 2.6 7.6 22.2 1.1 1 0 0 1 1 1 0 DDRGK domain UPF0242 PF06785.11 EEA20023.1 - 5.7 7.0 14.2 6.4 6.8 14.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Radial_spoke_3 PF06098.11 EEA20023.1 - 6 6.1 21.9 7 5.8 21.9 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 NARP1 PF12569.8 EEA20023.1 - 6.8 5.5 11.8 7 5.4 11.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TT_ORF1 PF02956.14 EEA20023.1 - 7.1 5.2 8.4 7 5.2 8.4 1.0 1 0 0 1 1 1 0 TT viral orf 1 DUF3987 PF13148.6 EEA20023.1 - 7.8 5.4 11.8 7.5 5.5 11.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF4407 PF14362.6 EEA20023.1 - 8 5.7 11.1 8 5.7 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) eIF3_subunit PF08597.10 EEA20023.1 - 9.3 6.1 17.8 9.8 6.0 17.8 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Rtf2 PF04641.12 EEA20023.1 - 9.3 5.5 10.3 9.8 5.5 10.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger APH PF01636.23 EEA20024.1 - 2e-06 27.9 1.5 7.5e-06 26.0 0.0 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA20024.1 - 1.7e-05 24.5 0.0 0.00019 21.1 0.0 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 EEA20024.1 - 0.0019 17.6 0.1 0.0039 16.6 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EEA20024.1 - 0.012 15.0 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain WaaY PF06176.11 EEA20024.1 - 0.09 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.23 EEA20025.1 - 0.0012 18.8 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family MFS_1 PF07690.16 EEA20026.1 - 1.1e-08 34.4 19.8 2.4e-08 33.3 19.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily HTH_Tnp_Tc5 PF03221.16 EEA20028.1 - 9.7e-12 44.8 0.7 6.8e-11 42.0 0.0 2.9 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 EEA20028.1 - 7.7e-08 32.2 0.1 1.7e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease CheR_N PF03705.15 EEA20028.1 - 0.32 10.7 0.0 0.32 10.7 0.0 2.8 3 0 0 3 3 3 0 CheR methyltransferase, all-alpha domain Myb_DNA-bind_7 PF15963.5 EEA20028.1 - 3.8 7.5 7.9 0.51 10.3 1.6 2.6 2 0 0 2 2 2 0 Myb DNA-binding like Esterase_phd PF10503.9 EEA20029.1 - 2.5e-19 69.7 1.2 4e-19 69.0 1.2 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase CBM_1 PF00734.18 EEA20029.1 - 5.8e-13 48.5 12.8 5.8e-13 48.5 12.8 2.6 2 0 0 2 2 2 1 Fungal cellulose binding domain Peptidase_S9 PF00326.21 EEA20029.1 - 2.4e-08 33.7 1.6 3.8e-08 33.1 1.2 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family COesterase PF00135.28 EEA20029.1 - 0.0011 18.0 0.8 0.0018 17.2 0.2 1.6 2 0 0 2 2 2 1 Carboxylesterase family DUF3439 PF11921.8 EEA20029.1 - 0.051 13.6 6.4 0.11 12.5 6.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DDE_3 PF13358.6 EEA20030.1 - 2.1e-16 60.0 0.0 3.5e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA20030.1 - 2.3e-08 34.1 2.1 3.1e-08 33.7 1.0 1.8 2 0 0 2 2 2 1 Transposase rve PF00665.26 EEA20030.1 - 0.094 12.9 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain 3HCDH_N PF02737.18 EEA20031.1 - 4.6e-25 88.5 0.0 8e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EEA20031.1 - 4.5e-22 78.5 0.0 1.2e-21 77.1 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Zn_clus PF00172.18 EEA20031.1 - 2.6e-05 24.2 7.1 2.6e-05 24.2 7.1 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ApbA PF02558.16 EEA20031.1 - 5.7e-05 22.8 0.0 0.0071 16.0 0.0 3.1 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 EEA20031.1 - 0.017 14.3 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA20031.1 - 0.018 15.6 0.0 0.049 14.2 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EEA20031.1 - 0.021 14.2 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HSDR_N_2 PF13588.6 EEA20031.1 - 0.091 12.8 0.0 0.45 10.5 0.0 2.2 2 1 1 3 3 3 0 Type I restriction enzyme R protein N terminus (HSDR_N) NAD_Gly3P_dh_N PF01210.23 EEA20031.1 - 0.13 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus MFS_1 PF07690.16 EEA20032.1 - 8.8e-37 126.8 31.4 1.1e-36 126.5 31.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3188 PF11384.8 EEA20032.1 - 0.46 10.2 3.5 1.9 8.3 2.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) Acyl_transf_3 PF01757.22 EEA20032.1 - 1.8 7.5 25.9 0.2 10.7 12.7 2.3 2 0 0 2 2 2 0 Acyltransferase family FeoB_C PF07664.12 EEA20032.1 - 2.8 7.7 0.0 2.8 7.7 0.0 3.7 3 1 1 4 4 4 0 Ferrous iron transport protein B C terminus MASE2 PF05230.11 EEA20032.1 - 5.4 7.2 12.6 0.06 13.4 1.9 2.9 3 0 0 3 3 3 0 MASE2 domain MFS_1_like PF12832.7 EEA20032.1 - 8.9 5.0 18.7 1 8.1 4.1 2.7 2 1 0 3 3 3 0 MFS_1 like family CBM_1 PF00734.18 EEA20033.1 - 1e-11 44.6 12.7 3.6e-11 42.8 12.7 2.1 1 0 0 1 1 1 1 Fungal cellulose binding domain BNR PF02012.20 EEA20033.1 - 0.00073 19.2 41.8 0.56 10.4 0.2 9.4 9 0 0 9 9 9 6 BNR/Asp-box repeat Kelch_3 PF13415.6 EEA20033.1 - 0.28 11.5 14.4 0.21 11.9 0.6 5.1 4 0 0 4 4 4 0 Galactose oxidase, central domain BNR_6 PF15899.5 EEA20033.1 - 1.9 8.7 11.3 7.1 7.0 0.1 6.1 8 0 0 8 8 8 0 BNR-Asp box repeat p450 PF00067.22 EEA20034.1 - 1.1e-45 156.2 0.0 1.5e-45 155.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 EEA20035.1 - 3.5e-69 233.8 23.1 4.1e-69 233.6 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA20035.1 - 7.8e-21 74.4 35.7 6e-14 51.7 18.8 2.7 1 1 2 3 3 3 3 Major Facilitator Superfamily Phage_holin_7_1 PF16081.5 EEA20035.1 - 0.044 14.0 0.8 0.1 12.8 0.8 1.6 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family DUF3792 PF12670.7 EEA20035.1 - 0.13 12.4 16.3 0.14 12.3 1.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) AA_permease PF00324.21 EEA20036.1 - 5.8e-41 140.6 20.1 3.2e-34 118.3 17.1 2.8 2 1 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EEA20036.1 - 7.8e-09 34.9 19.8 5.4e-08 32.1 14.4 2.4 2 1 0 2 2 2 2 Amino acid permease DUF983 PF06170.12 EEA20036.1 - 7.5 7.0 7.7 0.63 10.5 2.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF983) GCR1_C PF12550.8 EEA20037.1 - 2.3e-24 85.5 0.4 3.1e-24 85.1 0.4 1.1 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Arnt_C PF18583.1 EEA20037.1 - 0.041 13.5 0.1 0.078 12.6 0.1 1.5 2 0 0 2 2 2 0 Aminoarabinose transferase C-terminal domain DHDPS PF00701.22 EEA20038.1 - 6.8e-33 113.6 0.0 9e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF3830 PF12903.7 EEA20040.1 - 1.3e-25 89.8 0.0 1.6e-25 89.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3830) TauD PF02668.16 EEA20041.1 - 1.9e-47 162.3 0.6 2.4e-47 162.0 0.6 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DPRP PF04244.13 EEA20041.1 - 0.022 14.6 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein Amidohydro_1 PF01979.20 EEA20042.1 - 3.3e-21 76.0 0.0 8e-21 74.7 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA20042.1 - 7.8e-12 45.4 0.0 2.9e-06 27.0 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family NACHT PF05729.12 EEA20042.1 - 5e-06 26.5 0.1 1.3e-05 25.1 0.1 1.8 1 0 0 1 1 1 1 NACHT domain Goodbye PF17109.5 EEA20042.1 - 0.0028 18.1 0.0 0.0093 16.4 0.0 1.9 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain RNA_helicase PF00910.22 EEA20042.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Urease_alpha PF00449.20 EEA20042.1 - 0.15 12.4 0.1 0.33 11.3 0.1 1.5 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain Peptidase_M20 PF01546.28 EEA20043.1 - 2.4e-24 86.2 0.1 3.7e-24 85.6 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 GFO_IDH_MocA PF01408.22 EEA20043.1 - 8.2e-12 46.0 0.1 1.9e-11 44.9 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold M20_dimer PF07687.14 EEA20043.1 - 2.4e-05 24.2 0.0 5.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EEA20043.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M28 Homez PF11569.8 EEA20043.1 - 0.015 14.8 0.1 0.036 13.6 0.1 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez FSH1 PF03959.13 EEA20044.1 - 9.4e-25 87.5 0.0 1.5e-24 86.9 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) ketoacyl-synt PF00109.26 EEA20045.1 - 2.1e-71 240.4 0.0 3.6e-71 239.7 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA20045.1 - 1.4e-65 220.6 0.2 4.3e-65 219.0 0.1 2.0 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EEA20045.1 - 2.1e-47 162.2 0.1 5.3e-47 160.9 0.0 1.7 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.6 EEA20045.1 - 4.7e-46 157.4 0.0 7.6e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EEA20045.1 - 4.3e-39 133.2 0.2 2.4e-38 130.8 0.1 2.5 3 0 0 3 3 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EEA20045.1 - 5.7e-19 68.3 0.7 1.6e-18 66.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KAsynt_C_assoc PF16197.5 EEA20045.1 - 3e-16 59.9 0.0 9e-16 58.3 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EEA20045.1 - 6.3e-14 52.1 0.0 3.3e-13 49.8 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA20045.1 - 1e-13 52.5 0.0 5e-13 50.2 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EEA20045.1 - 1.1e-10 41.5 0.0 3.9e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EEA20045.1 - 2.9e-06 27.1 0.4 8.2e-06 25.7 0.4 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EEA20045.1 - 3.2e-06 27.4 1.3 1e-05 25.8 1.3 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EEA20045.1 - 0.0046 16.4 0.0 0.0096 15.3 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 EEA20045.1 - 0.01 15.0 0.0 0.022 13.9 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ACP_syn_III PF08545.10 EEA20045.1 - 0.02 14.8 0.6 0.073 12.9 0.6 2.0 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GDP_Man_Dehyd PF16363.5 EEA20045.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase SnoaL_4 PF13577.6 EEA20046.1 - 2.1e-20 73.2 0.0 2.4e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain TSLP PF15216.6 EEA20047.1 - 0.22 11.8 0.1 0.36 11.1 0.1 1.3 1 0 0 1 1 1 0 Thymic stromal lymphopoietin Sugar_tr PF00083.24 EEA20048.1 - 0.00017 20.6 0.1 0.07 12.0 0.1 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter Glyoxalase PF00903.25 EEA20049.1 - 6.3e-07 29.6 0.0 9.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MPC PF03650.13 EEA20050.1 - 3.7e-33 114.0 0.1 4.4e-33 113.7 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers LAB_N PF07578.11 EEA20050.1 - 0.013 15.5 0.1 6.1 7.0 0.0 2.3 2 0 0 2 2 2 0 Lipid A Biosynthesis N-terminal domain FAD_binding_3 PF01494.19 EEA20051.1 - 2.7e-77 260.4 0.0 3.4e-77 260.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EEA20051.1 - 1.3e-45 155.4 0.0 3.3e-45 154.1 0.0 1.7 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain Thi4 PF01946.17 EEA20051.1 - 0.011 15.0 0.2 0.018 14.3 0.2 1.3 1 0 0 1 1 1 0 Thi4 family SE PF08491.10 EEA20051.1 - 0.016 14.3 0.0 0.19 10.7 0.0 2.1 1 1 0 1 1 1 0 Squalene epoxidase DAO PF01266.24 EEA20051.1 - 0.033 13.8 0.3 0.73 9.4 0.3 2.3 2 1 1 3 3 3 0 FAD dependent oxidoreductase MCRA PF06100.11 EEA20051.1 - 0.069 11.9 0.1 0.13 11.0 0.1 1.3 1 0 0 1 1 1 0 MCRA family FAD_binding_2 PF00890.24 EEA20051.1 - 0.086 11.9 1.4 0.17 11.0 1.4 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 EEA20051.1 - 0.12 12.6 0.4 0.63 10.3 0.1 2.3 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain AA_permease_2 PF13520.6 EEA20053.1 - 3.2e-63 214.0 54.4 4e-63 213.7 54.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA20053.1 - 7.7e-20 70.9 40.0 1e-19 70.6 40.0 1.0 1 0 0 1 1 1 1 Amino acid permease RGS PF00615.19 EEA20054.1 - 4.7e-28 97.8 0.2 4.1e-27 94.8 0.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 EEA20054.1 - 6e-17 61.5 0.1 9.7e-16 57.6 0.0 2.7 3 0 0 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GFO_IDH_MocA PF01408.22 EEA20055.1 - 6.4e-25 88.3 0.0 1e-24 87.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EEA20055.1 - 0.0043 17.5 0.0 0.0086 16.5 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 EEA20055.1 - 0.04 14.6 0.0 0.07 13.8 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GST_N_2 PF13409.6 EEA20056.1 - 2.2e-19 69.5 0.0 4.9e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA20056.1 - 2.7e-11 43.3 0.0 7.6e-11 41.9 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA20056.1 - 0.0041 17.5 0.0 5.4 7.5 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA20056.1 - 0.0044 17.2 0.0 0.0097 16.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA20056.1 - 0.062 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA20057.1 - 1.8e-19 69.8 0.0 4.1e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA20057.1 - 2.2e-11 43.6 0.0 6.5e-11 42.1 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA20057.1 - 0.0037 17.4 0.0 0.0082 16.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA20057.1 - 0.0089 16.4 0.0 4.8 7.7 0.0 2.6 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA20057.1 - 0.051 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Aldo_ket_red PF00248.21 EEA20058.1 - 2.4e-70 237.1 0.0 2.7e-70 236.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Zn_clus PF00172.18 EEA20059.1 - 3.7e-09 36.6 7.4 6.8e-09 35.7 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA20060.1 - 2e-37 128.9 51.4 2e-37 128.9 51.4 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA20060.1 - 3.8e-15 55.3 19.1 5e-15 54.9 19.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.18 EEA20061.1 - 8.1e-09 35.5 10.9 1.4e-08 34.7 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA20061.1 - 3.2e-07 29.5 0.5 4.6e-07 29.0 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.26 EEA20062.1 - 1.1e-13 51.3 0.0 2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA20062.1 - 1e-10 41.4 0.0 2e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EEA20062.1 - 0.0002 21.2 0.0 0.00045 20.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EEA20062.1 - 0.0002 22.4 0.0 0.00038 21.5 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Chromate_transp PF02417.15 EEA20063.1 - 8.3e-62 208.0 38.8 7.8e-32 110.6 12.4 2.6 2 1 0 2 2 2 2 Chromate transporter DUF5533 PF17685.1 EEA20063.1 - 0.0026 18.2 1.4 0.0085 16.5 1.4 2.0 1 0 0 1 1 1 1 Family of unknown function (DUF5533) Zn_clus PF00172.18 EEA20064.1 - 1.4e-07 31.5 9.3 3.2e-07 30.4 9.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_jaz PF12171.8 EEA20064.1 - 0.16 12.3 0.2 0.16 12.3 0.2 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EEA20064.1 - 10 6.8 8.1 0.65 10.6 0.3 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type Acetyltransf_1 PF00583.25 EEA20065.1 - 0.00011 22.5 0.0 0.00015 22.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA20065.1 - 0.01 15.8 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA20065.1 - 0.044 13.9 0.0 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF3425 PF11905.8 EEA20067.1 - 5.8e-15 55.4 0.4 1.3e-14 54.2 0.4 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) DUF3425 PF11905.8 EEA20068.1 - 5.8e-15 55.4 0.4 1.3e-14 54.2 0.4 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) WW PF00397.26 EEA20069.1 - 1.6e-06 28.1 1.5 5.3e-06 26.4 1.5 2.0 1 0 0 1 1 1 1 WW domain Extensin_2 PF04554.13 EEA20069.1 - 7.6 6.7 55.0 20 5.4 24.7 3.6 1 1 1 2 2 2 0 Extensin-like region Cerato-platanin PF07249.12 EEA20070.1 - 7.8e-38 129.2 1.9 1e-37 128.9 1.9 1.1 1 0 0 1 1 1 1 Cerato-platanin RSN1_7TM PF02714.15 EEA20071.1 - 1.6e-87 293.3 20.7 1.6e-87 293.3 20.7 2.0 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EEA20071.1 - 1.3e-41 142.0 1.5 1.3e-41 142.0 1.5 2.2 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EEA20071.1 - 6.8e-34 117.6 1.6 1.3e-33 116.8 1.6 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EEA20071.1 - 1.6e-26 92.3 0.2 5.4e-26 90.6 0.2 1.9 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter RRM_1 PF00076.22 EEA20071.1 - 0.094 12.6 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Striatin PF08232.12 EEA20073.1 - 1.2e-45 155.8 6.6 1.2e-45 155.8 6.6 2.5 2 0 0 2 2 2 1 Striatin family WD40 PF00400.32 EEA20073.1 - 1.9e-25 88.6 22.4 3.4e-05 24.5 0.5 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20073.1 - 6.2e-05 23.2 0.1 0.54 10.6 0.0 4.6 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA20073.1 - 0.041 13.8 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A ADH_N_2 PF16884.5 EEA20073.1 - 0.076 12.9 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Ge1_WD40 PF16529.5 EEA20073.1 - 0.16 10.9 0.0 0.37 9.7 0.0 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2570 PF10828.8 EEA20073.1 - 0.8 9.5 14.1 0.36 10.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) TFIIA PF03153.13 EEA20073.1 - 1.5 8.7 20.7 2.2 8.2 20.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PIG-P PF08510.12 EEA20074.1 - 1.9e-53 179.5 1.4 3.4e-53 178.7 1.4 1.4 1 0 0 1 1 1 1 PIG-P Glyco_trans_2_3 PF13632.6 EEA20074.1 - 0.18 11.7 2.1 0.29 11.0 2.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase family group 2 DPM2 PF07297.12 EEA20074.1 - 0.33 11.3 9.8 0.58 10.5 9.8 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) NMO PF03060.15 EEA20075.1 - 1.5e-32 113.3 3.9 1.7e-23 83.6 0.5 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 EEA20075.1 - 4.4e-06 25.9 2.2 8.9e-05 21.6 2.2 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EEA20075.1 - 0.00018 20.6 0.4 0.00032 19.8 0.4 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EEA20075.1 - 0.074 12.2 0.5 0.23 10.5 0.5 1.7 1 1 0 1 1 1 0 Conserved region in glutamate synthase XPA_C PF05181.12 EEA20076.1 - 1e-25 89.5 3.1 2.1e-25 88.4 3.1 1.6 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 EEA20076.1 - 0.01 15.8 8.6 0.01 15.8 8.6 2.2 2 0 0 2 2 2 0 XPA protein N-terminal Blt1 PF12754.7 EEA20077.1 - 9.6e-63 211.0 0.1 1.4e-62 210.4 0.1 1.3 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 EEA20077.1 - 1.7e-22 78.7 0.3 3.4e-22 77.8 0.3 1.5 1 0 0 1 1 1 1 Get5 carboxyl domain Methyltr_RsmB-F PF01189.17 EEA20078.1 - 9.1e-73 244.2 0.0 1.6e-72 243.4 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EEA20078.1 - 4.6e-07 30.2 0.0 1.2e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EEA20078.1 - 0.023 14.8 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase ANTAR PF03861.14 EEA20078.1 - 3.3 7.6 6.7 0.43 10.4 1.1 2.5 3 0 0 3 3 3 0 ANTAR domain Acyl-CoA_dh_1 PF00441.24 EEA20079.1 - 1.9e-31 109.3 1.2 3.7e-31 108.4 1.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 EEA20079.1 - 1.7e-21 76.1 0.1 4.8e-21 74.7 0.1 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 EEA20079.1 - 3.6e-17 62.3 0.3 7.3e-17 61.4 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA20079.1 - 1.2e-07 32.1 0.3 2.4e-07 31.1 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA20079.1 - 9.9e-07 29.4 0.2 3e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Corona_NS2A PF05213.12 EEA20079.1 - 0.031 13.6 0.2 0.56 9.5 0.1 2.2 2 0 0 2 2 2 0 Coronavirus NS2A protein DS PF01916.17 EEA20080.1 - 2.2e-114 381.6 0.1 2e-113 378.4 0.1 1.9 1 1 0 1 1 1 1 Deoxyhypusine synthase MORN PF02493.20 EEA20081.1 - 1.2e-16 59.5 26.0 5.7e-06 25.9 0.6 4.5 4 0 0 4 4 4 4 MORN repeat UCH PF00443.29 EEA20081.1 - 6.9e-16 58.5 0.0 1.4e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_3 PF13920.6 EEA20081.1 - 2.7e-10 40.0 10.8 4.3e-10 39.3 10.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) USP7_ICP0_bdg PF12436.8 EEA20081.1 - 3.7e-05 23.2 0.0 9.3e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 Prok-RING_4 PF14447.6 EEA20081.1 - 0.014 15.2 10.2 0.027 14.3 10.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EEA20081.1 - 0.68 9.9 11.4 1.3 9.0 11.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Myb_DNA-binding PF00249.31 EEA20082.1 - 1.6e-13 50.6 0.0 3.9e-10 39.8 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA20082.1 - 0.0046 16.8 0.0 0.0046 16.8 0.0 3.2 4 0 0 4 4 4 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EEA20082.1 - 0.0097 16.1 0.2 0.63 10.3 0.1 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain CHAT PF12770.7 EEA20085.1 - 7.2e-36 124.1 0.8 1e-35 123.6 0.1 1.6 2 0 0 2 2 2 1 CHAT domain TPR_12 PF13424.6 EEA20085.1 - 0.017 15.4 0.2 0.017 15.4 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA20085.1 - 0.025 14.4 0.3 0.33 10.9 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EEA20085.1 - 0.044 13.8 1.0 0.38 10.9 0.1 2.9 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 EEA20085.1 - 0.089 13.0 0.2 0.91 9.9 0.2 2.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA20085.1 - 0.098 12.8 3.1 0.25 11.6 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ArfGap PF01412.18 EEA20085.1 - 0.12 12.5 0.6 1 9.5 0.0 2.8 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf SNAP PF14938.6 EEA20085.1 - 0.18 11.2 4.1 0.31 10.4 0.2 2.7 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP Pro_isomerase PF00160.21 EEA20086.1 - 3.7e-36 124.8 0.0 7.7e-36 123.8 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD His_Phos_2 PF00328.22 EEA20088.1 - 0.0028 17.1 0.3 0.23 10.7 0.0 3.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) AAA PF00004.29 EEA20089.1 - 6.9e-17 62.1 0.0 1.3e-16 61.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EEA20089.1 - 1.9e-16 60.2 0.0 7.3e-16 58.3 0.0 2.0 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EEA20089.1 - 1.6e-11 44.3 1.4 3.4e-11 43.2 0.0 2.2 2 1 0 2 2 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EEA20089.1 - 4.3e-09 36.6 0.0 9.5e-09 35.4 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 EEA20089.1 - 1.7e-07 31.1 0.1 5.6e-07 29.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 EEA20089.1 - 6.6e-07 29.6 0.1 3.4e-06 27.3 0.0 2.3 2 1 1 3 3 2 1 AAA C-terminal domain AAA_22 PF13401.6 EEA20089.1 - 1.1e-06 29.0 0.4 1.2e-05 25.6 0.1 2.8 3 2 0 3 3 2 1 AAA domain AAA_11 PF13086.6 EEA20089.1 - 2.5e-06 27.5 0.2 8.3e-05 22.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA20089.1 - 2.5e-06 28.0 0.0 8.3e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EEA20089.1 - 6e-06 26.3 0.0 0.0006 19.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA20089.1 - 1.4e-05 25.1 0.2 0.00018 21.5 0.1 2.8 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EEA20089.1 - 3.8e-05 23.5 0.0 6.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EEA20089.1 - 4.7e-05 23.2 0.0 0.00014 21.7 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EEA20089.1 - 5.2e-05 23.6 0.1 0.00018 21.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EEA20089.1 - 8.8e-05 22.4 0.0 0.00017 21.5 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_3 PF07726.11 EEA20089.1 - 0.00014 21.7 0.2 0.00063 19.6 0.2 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EEA20089.1 - 0.00018 21.6 0.0 0.047 13.7 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF815 PF05673.13 EEA20089.1 - 0.00043 19.5 0.0 0.0008 18.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EEA20089.1 - 0.0012 19.4 0.0 0.0022 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EEA20089.1 - 0.0014 18.9 0.0 0.0032 17.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 EEA20089.1 - 0.0022 17.5 0.0 0.35 10.3 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein TniB PF05621.11 EEA20089.1 - 0.0028 17.1 0.0 0.025 14.0 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein AAA_25 PF13481.6 EEA20089.1 - 0.0082 15.7 0.0 0.021 14.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 EEA20089.1 - 0.0094 15.7 0.1 0.09 12.5 0.1 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EEA20089.1 - 0.01 15.1 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TK PF00265.18 EEA20089.1 - 0.01 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Thymidine kinase Sigma54_activat PF00158.26 EEA20089.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 EEA20089.1 - 0.015 15.8 0.0 0.027 15.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 EEA20089.1 - 0.019 14.4 0.0 0.043 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 EEA20089.1 - 0.02 14.5 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 EEA20089.1 - 0.022 14.2 0.2 0.15 11.4 0.2 2.3 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA20089.1 - 0.029 14.8 0.0 0.071 13.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 EEA20089.1 - 0.041 12.9 0.0 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 EEA20089.1 - 0.064 13.0 0.0 0.62 9.8 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase_2 PF01637.18 EEA20089.1 - 0.069 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EEA20089.1 - 0.072 13.0 0.1 1.2 9.0 0.1 2.3 1 1 0 2 2 2 0 NTPase F_actin_cap_B PF01115.17 EEA20089.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 F-actin capping protein, beta subunit P21-Arc PF04062.14 EEA20090.1 - 1.2e-73 246.9 0.0 1.3e-73 246.7 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.18 EEA20090.1 - 0.023 14.8 0.1 0.042 13.9 0.1 1.4 1 0 0 1 1 1 0 Pancreatic hormone peptide P21-Arc PF04062.14 EEA20091.1 - 1.4e-62 210.8 0.0 1.8e-62 210.4 0.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.18 EEA20091.1 - 0.028 14.5 0.1 0.051 13.6 0.1 1.4 1 0 0 1 1 1 0 Pancreatic hormone peptide Gcd10p PF04189.13 EEA20092.1 - 6.8e-122 406.3 0.2 8.5e-122 406.0 0.2 1.1 1 0 0 1 1 1 1 Gcd10p family FF PF01846.19 EEA20092.1 - 0.73 10.1 2.6 0.65 10.2 0.7 1.9 2 0 0 2 2 2 0 FF domain MINDY_DUB PF04424.13 EEA20093.1 - 3.5e-20 72.2 0.0 6.9e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase Roughex PF06020.11 EEA20093.1 - 0.46 9.5 9.7 0.89 8.6 9.7 1.4 1 0 0 1 1 1 0 Drosophila roughex protein HSF_DNA-bind PF00447.17 EEA20094.1 - 9e-28 96.7 0.2 2e-27 95.6 0.2 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding TMF_DNA_bd PF12329.8 EEA20094.1 - 0.0069 16.4 1.7 0.3 11.1 0.1 2.5 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Ets PF00178.22 EEA20094.1 - 0.013 16.0 0.0 0.031 14.8 0.0 1.6 1 0 0 1 1 1 0 Ets-domain Pex19 PF04614.12 EEA20094.1 - 0.048 13.4 0.2 0.28 10.9 0.1 2.3 2 0 0 2 2 2 0 Pex19 protein family JHY PF15261.6 EEA20094.1 - 0.079 13.7 0.2 0.079 13.7 0.2 2.7 3 0 0 3 3 2 0 Jhy protein CENP-F_leu_zip PF10473.9 EEA20094.1 - 0.092 12.8 2.4 4.5 7.3 0.2 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Aminopep PF10023.9 EEA20094.1 - 0.11 11.9 1.5 7.6 5.8 0.3 2.7 2 1 0 2 2 2 0 Putative aminopeptidase APG6_N PF17675.1 EEA20094.1 - 0.11 13.0 1.6 0.34 11.4 0.2 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4404 PF14357.6 EEA20094.1 - 0.12 13.1 0.9 1.1 9.9 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) MRP-L28 PF09812.9 EEA20094.1 - 0.19 11.9 2.5 0.39 10.8 0.9 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 TRAF_BIRC3_bd PF16673.5 EEA20094.1 - 0.26 11.1 0.6 1 9.2 0.6 2.0 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Aldo_ket_red PF00248.21 EEA20095.1 - 2e-11 43.6 0.0 7e-11 41.9 0.0 1.8 2 1 0 2 2 2 1 Aldo/keto reductase family COesterase PF00135.28 EEA20096.1 - 1.4e-87 294.7 0.0 1.9e-87 294.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA20096.1 - 1.6e-07 31.4 0.0 3.6e-06 27.0 0.1 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA20096.1 - 0.0019 17.7 0.2 0.0036 16.8 0.2 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Sugar_tr PF00083.24 EEA20098.1 - 1e-11 44.4 6.1 1.1e-11 44.3 6.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA20098.1 - 3.2e-05 23.0 14.1 4.6e-05 22.5 13.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20099.1 - 7.3e-18 64.7 1.7 8.3e-18 64.5 1.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA20099.1 - 1.4e-07 30.8 9.8 1.8e-07 30.4 9.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily R3H PF01424.22 EEA20100.1 - 1.5e-10 40.9 1.1 2.1e-10 40.4 0.1 1.8 2 0 0 2 2 2 1 R3H domain RRM_1 PF00076.22 EEA20100.1 - 2.9e-06 27.0 0.1 5.1e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAS_C PF12026.8 EEA20100.1 - 0.22 11.6 0.3 0.34 11.0 0.3 1.2 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Histone PF00125.24 EEA20102.1 - 1.1e-16 61.4 0.0 1.4e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EEA20102.1 - 1.7e-12 46.8 0.0 3.4e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EEA20102.1 - 3.5e-05 24.0 0.0 4.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pho88 PF10032.9 EEA20103.1 - 3.6e-82 274.0 0.2 4e-82 273.9 0.2 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Gp_dh_C PF02800.20 EEA20104.1 - 6.7e-69 230.5 0.0 1e-68 229.9 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EEA20104.1 - 1.3e-37 128.2 1.2 3.9e-37 126.6 0.3 2.1 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EEA20104.1 - 0.0027 17.8 0.1 0.0096 16.0 0.0 2.0 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.22 EEA20104.1 - 0.14 13.0 0.1 1.2 10.0 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Arb2 PF09757.9 EEA20105.1 - 3.5e-105 350.8 0.7 4.6e-105 350.4 0.7 1.1 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 EEA20105.1 - 4.6e-85 285.8 0.0 6.3e-85 285.3 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Peptidase_M16_M PF16187.5 EEA20106.1 - 6.7e-97 324.1 0.8 1.4e-96 323.1 0.8 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EEA20106.1 - 4.5e-35 121.3 0.1 1.6e-21 77.1 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA20106.1 - 2.7e-30 105.3 7.9 1.2e-28 100.0 2.7 4.0 2 2 1 3 3 3 1 Insulinase (Peptidase family M16) NUDIX_2 PF13869.6 EEA20107.1 - 4.3e-81 271.0 0.0 5.1e-81 270.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase Lipase_3 PF01764.25 EEA20108.1 - 4.1e-27 94.8 0.1 5.9e-27 94.3 0.1 1.2 1 0 0 1 1 1 1 Lipase (class 3) Lipase3_N PF03893.16 EEA20108.1 - 4.8e-07 29.7 0.2 1.1e-06 28.6 0.2 1.6 1 0 0 1 1 1 1 Lipase 3 N-terminal region DUF2048 PF09752.9 EEA20108.1 - 0.16 11.1 0.1 0.21 10.6 0.1 1.1 1 0 0 1 1 1 0 Abhydrolase domain containing 18 DUF3431 PF11913.8 EEA20109.1 - 8.1e-87 290.5 0.2 9.8e-87 290.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DUF3431 PF11913.8 EEA20110.1 - 4.2e-77 258.8 0.1 5.5e-77 258.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) CoaE PF01121.20 EEA20111.1 - 1.5e-43 148.6 0.0 1.9e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 EEA20111.1 - 0.014 15.5 0.0 0.11 12.6 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA20111.1 - 0.036 14.6 0.2 0.23 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain HCV_env PF01539.17 EEA20111.1 - 0.054 13.2 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 Amino_oxidase PF01593.24 EEA20112.1 - 7.6e-84 282.6 0.2 1.2e-72 245.7 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase SWIRM PF04433.17 EEA20112.1 - 1e-12 48.2 0.1 2.3e-12 47.1 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 EEA20112.1 - 1.7e-08 34.5 0.0 3.9e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.19 EEA20112.1 - 0.001 19.5 2.1 0.0028 18.0 2.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box DAO PF01266.24 EEA20112.1 - 0.002 17.8 1.1 0.002 17.8 1.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EEA20112.1 - 0.0063 16.5 0.1 0.04 13.9 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EEA20112.1 - 0.02 14.1 0.4 0.075 12.3 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA20112.1 - 0.051 12.8 0.0 0.096 11.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EEA20112.1 - 0.065 12.5 0.4 1.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 EEA20113.1 - 1.2e-65 222.1 0.0 1.6e-65 221.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_transf_22 PF03901.17 EEA20114.1 - 1.3e-44 153.1 17.8 1.6e-44 152.8 17.8 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CPP1-like PF11833.8 EEA20114.1 - 1.2 8.8 4.3 0.37 10.4 0.2 2.2 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Yos1 PF08571.10 EEA20115.1 - 8.5e-36 122.1 0.4 9.4e-36 121.9 0.4 1.0 1 0 0 1 1 1 1 Yos1-like Abhydrolase_6 PF12697.7 EEA20116.1 - 7.9e-12 46.2 0.0 9.2e-12 46.0 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA20116.1 - 1.2e-09 37.8 0.0 2.5e-09 36.8 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EEA20116.1 - 4.7e-07 30.2 0.0 7.3e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.16 EEA20116.1 - 7.2e-06 26.0 0.5 0.096 12.5 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase PGAP1 PF07819.13 EEA20116.1 - 3.3e-05 23.7 1.2 0.00015 21.6 0.4 2.4 2 1 0 2 2 2 1 PGAP1-like protein LIDHydrolase PF10230.9 EEA20116.1 - 5e-05 23.0 0.2 0.00013 21.6 0.2 1.7 1 1 1 2 2 2 1 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 EEA20116.1 - 0.0014 18.4 0.7 0.0091 15.8 0.1 2.3 2 1 1 3 3 3 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EEA20116.1 - 0.0027 17.2 1.5 1 8.8 0.0 2.4 2 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EEA20116.1 - 0.0046 16.6 0.0 0.51 9.9 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.13 EEA20116.1 - 0.007 16.1 0.1 0.024 14.3 0.1 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) PE-PPE PF08237.11 EEA20116.1 - 0.0087 15.6 0.8 0.21 11.1 0.1 2.2 2 0 0 2 2 2 1 PE-PPE domain DUF676 PF05057.14 EEA20116.1 - 0.035 13.6 0.3 0.083 12.4 0.1 1.7 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Abhydrolase_8 PF06259.12 EEA20116.1 - 0.038 13.6 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Lipase_3 PF01764.25 EEA20116.1 - 0.051 13.4 1.0 0.38 10.6 0.1 2.3 1 1 0 2 2 2 0 Lipase (class 3) Peptidase_S10 PF00450.22 EEA20116.1 - 0.078 12.4 0.1 6.4 6.1 0.0 2.1 2 0 0 2 2 2 0 Serine carboxypeptidase DUF900 PF05990.12 EEA20116.1 - 0.082 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Esterase PF00756.20 EEA20116.1 - 0.23 11.0 0.5 22 4.6 0.2 2.9 2 1 1 3 3 3 0 Putative esterase AAA_22 PF13401.6 EEA20117.1 - 0.14 12.5 0.0 0.36 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain UCH PF00443.29 EEA20118.1 - 7.7e-58 196.0 0.4 1.5e-57 195.0 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA20118.1 - 1.1e-27 97.5 2.9 2.5e-20 73.3 0.3 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EEA20118.1 - 0.0011 18.6 3.6 0.035 13.6 2.3 3.0 3 0 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase Vfa1 PF08432.10 EEA20118.1 - 7.7 6.8 19.0 1.1 9.6 12.2 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 tRNA-synt_His PF13393.6 EEA20119.1 - 1.9e-34 119.3 0.0 2.3e-28 99.4 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EEA20119.1 - 6.7e-13 48.6 0.0 1.4e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EEA20119.1 - 3.9e-05 23.7 0.0 7.3e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 EEA20119.1 - 0.006 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs FAD_binding_3 PF01494.19 EEA20120.1 - 3.3e-21 75.9 0.0 6.3e-19 68.4 0.0 2.9 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EEA20120.1 - 0.0009 18.4 0.0 0.0014 17.7 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase Lycopene_cycl PF05834.12 EEA20120.1 - 0.0015 17.7 0.1 0.0043 16.2 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EEA20120.1 - 0.0034 17.4 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EEA20120.1 - 0.0081 15.4 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EEA20120.1 - 0.01 14.7 0.0 0.14 11.0 0.0 2.3 3 0 0 3 3 3 0 Tryptophan halogenase K_oxygenase PF13434.6 EEA20120.1 - 0.019 14.1 0.0 0.034 13.3 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EEA20120.1 - 0.023 14.9 0.1 0.058 13.6 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA20120.1 - 0.17 11.1 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Thi4 family zf-LITAF-like PF10601.9 EEA20122.1 - 2.4e-16 59.7 10.9 3.5e-16 59.2 10.9 1.3 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Elf1 PF05129.13 EEA20122.1 - 3.1 7.9 8.9 48 4.1 8.9 2.2 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-LITAF-like PF10601.9 EEA20123.1 - 2.4e-16 59.7 10.9 3.5e-16 59.2 10.9 1.3 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Elf1 PF05129.13 EEA20123.1 - 3.1 7.9 8.9 48 4.1 8.9 2.2 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-LITAF-like PF10601.9 EEA20124.1 - 2.4e-16 59.7 10.9 3.5e-16 59.2 10.9 1.3 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Elf1 PF05129.13 EEA20124.1 - 3.1 7.9 8.9 48 4.1 8.9 2.2 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like BLUF PF04940.12 EEA20125.1 - 0.00018 21.6 0.0 0.00023 21.2 0.0 1.1 1 0 0 1 1 1 1 Sensors of blue-light using FAD GKAP PF03359.13 EEA20125.1 - 0.036 13.6 0.0 0.042 13.4 0.0 1.0 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein Cas_Cas6 PF01881.16 EEA20125.1 - 0.13 12.9 0.0 0.14 12.7 0.0 1.1 1 0 0 1 1 1 0 CRISPR associated protein Cas6 PX PF00787.24 EEA20126.1 - 2.6e-19 69.3 0.1 5.1e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EEA20126.1 - 3.8e-14 52.8 3.7 7.8e-07 28.9 0.4 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.18 EEA20126.1 - 0.0094 15.6 1.7 0.26 10.9 1.7 2.3 1 1 0 1 1 1 1 BAR domain Sec34 PF04136.15 EEA20126.1 - 0.035 14.0 0.2 0.074 12.9 0.0 1.6 2 0 0 2 2 2 0 Sec34-like family Occludin_ELL PF07303.13 EEA20126.1 - 0.12 13.1 1.3 2.3 9.0 0.0 2.8 3 0 0 3 3 3 0 Occludin homology domain DUF1664 PF07889.12 EEA20126.1 - 0.26 11.3 1.6 7.5 6.6 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Peptidase_S8 PF00082.22 EEA20128.1 - 1.7e-37 129.3 0.6 2.5e-37 128.8 0.6 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EEA20128.1 - 9.5e-25 86.5 0.7 1.8e-24 85.6 0.7 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain PhoD PF09423.10 EEA20129.1 - 0.00029 20.0 0.0 0.0021 17.2 0.0 2.1 1 1 0 1 1 1 1 PhoD-like phosphatase CAMSAP_CC1 PF17095.5 EEA20129.1 - 0.028 14.3 0.2 0.061 13.2 0.2 1.5 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin Pyr_redox_2 PF07992.14 EEA20130.1 - 4.3e-51 173.9 0.1 5.3e-51 173.6 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA20130.1 - 1.5e-18 67.1 0.1 6.6e-17 61.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA20130.1 - 3.5e-16 59.5 0.3 1.1e-13 51.5 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA20130.1 - 0.00012 21.5 0.4 0.00028 20.2 0.1 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_7 PF13241.6 EEA20130.1 - 0.00013 22.4 0.2 0.01 16.2 0.1 2.7 2 1 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EEA20130.1 - 0.00031 20.9 0.3 0.14 12.4 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EEA20130.1 - 0.00064 19.1 2.7 2.1 7.5 0.0 3.1 2 1 1 3 3 3 2 FAD binding domain K_oxygenase PF13434.6 EEA20130.1 - 0.0019 17.4 0.0 0.21 10.7 0.0 2.9 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EEA20130.1 - 0.0035 16.7 0.4 0.18 11.1 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EEA20130.1 - 0.012 14.7 3.8 2.1 7.3 0.1 4.0 4 1 1 5 5 5 0 Glucose inhibited division protein A DAO PF01266.24 EEA20130.1 - 0.023 14.3 4.3 3.6 7.1 0.0 3.6 2 2 1 4 4 4 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EEA20130.1 - 0.12 12.4 0.4 19 5.3 0.0 2.9 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EEA20130.1 - 1.4 7.9 6.5 0.88 8.6 0.8 2.8 2 1 2 4 4 4 0 FAD binding domain Dynamitin PF04912.14 EEA20131.1 - 6.2e-74 249.7 10.2 2.1e-73 247.9 10.2 1.7 1 1 0 1 1 1 1 Dynamitin Laminin_II PF06009.12 EEA20131.1 - 0.0059 16.6 0.8 0.0059 16.6 0.8 3.4 3 1 1 4 4 4 1 Laminin Domain II DUF948 PF06103.11 EEA20131.1 - 0.022 15.0 0.2 4.7 7.6 0.0 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc24 PF08286.11 EEA20131.1 - 0.045 14.0 5.9 4.7 7.5 0.2 3.6 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 FapA PF03961.13 EEA20131.1 - 0.078 11.6 2.4 0.07 11.7 0.4 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A DivIC PF04977.15 EEA20131.1 - 0.098 12.4 18.7 0.073 12.8 1.6 4.4 5 0 0 5 5 5 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 EEA20131.1 - 0.19 11.9 10.2 1 9.6 2.4 3.2 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 SlyX PF04102.12 EEA20131.1 - 0.33 11.6 10.0 3.2 8.4 1.1 4.1 4 1 0 4 4 3 0 SlyX End3 PF12761.7 EEA20131.1 - 0.55 10.4 8.5 0.056 13.6 1.5 2.7 3 0 0 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 MIP-T3_C PF17749.1 EEA20131.1 - 1.3 8.9 7.3 0.35 10.8 1.4 2.7 3 0 0 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region FlxA PF14282.6 EEA20131.1 - 1.7 8.6 10.1 2.9 8.0 0.1 4.2 4 0 0 4 4 4 0 FlxA-like protein APG6_N PF17675.1 EEA20131.1 - 2 9.0 13.7 2.5 8.6 3.9 3.0 3 0 0 3 3 3 0 Apg6 coiled-coil region LPP PF04728.13 EEA20131.1 - 2.1 8.8 9.1 0.39 11.1 0.5 3.7 5 0 0 5 5 5 0 Lipoprotein leucine-zipper DUF2203 PF09969.9 EEA20131.1 - 2.8 8.7 9.7 4.1 8.2 0.9 3.4 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) TMF_DNA_bd PF12329.8 EEA20131.1 - 9.3 6.3 13.3 1.5 8.9 2.8 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Aldedh PF00171.22 EEA20133.1 - 5.3e-135 450.5 0.3 6.4e-135 450.2 0.3 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EEA20133.1 - 0.15 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF3537 PF12056.8 EEA20133.1 - 0.58 8.9 2.3 0.83 8.4 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Calreticulin PF00262.18 EEA20134.1 - 1.3e-167 557.3 18.3 1.6e-167 557.0 18.3 1.1 1 0 0 1 1 1 1 Calreticulin family MT0933_antitox PF14013.6 EEA20134.1 - 0.29 11.5 5.5 0.74 10.2 5.5 1.7 1 0 0 1 1 1 0 MT0933-like antitoxin protein Aldolase_II PF00596.21 EEA20135.1 - 6.8e-45 153.3 0.0 8.1e-45 153.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Vps5 PF09325.10 EEA20136.1 - 3.3e-88 295.2 3.1 5.7e-88 294.4 3.1 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EEA20136.1 - 5.1e-25 87.6 0.0 1.3e-24 86.3 0.0 1.7 1 0 0 1 1 1 1 PX domain BAR_3 PF16746.5 EEA20136.1 - 0.0093 15.7 4.6 0.34 10.6 1.0 2.4 1 1 1 2 2 2 2 BAR domain of APPL family DUF3450 PF11932.8 EEA20136.1 - 0.23 10.7 7.0 0.077 12.3 3.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Pup PF05639.11 EEA20138.1 - 0.017 16.0 0.9 0.031 15.2 0.9 1.4 1 0 0 1 1 1 0 Pup-like protein Flavin_Reduct PF01613.18 EEA20139.1 - 1.1e-25 90.5 0.0 1.9e-25 89.7 0.0 1.4 1 1 0 1 1 1 1 Flavin reductase like domain DUF1612 PF07756.12 EEA20140.1 - 1.7 8.9 11.5 0.85 9.9 2.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1612) 4HBT_2 PF13279.6 EEA20141.1 - 6.8e-31 107.3 0.1 1.1e-30 106.7 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EEA20141.1 - 3.9e-05 23.9 0.0 0.00015 22.1 0.0 2.0 1 1 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 EEA20141.1 - 0.053 12.8 0.2 0.19 11.0 0.1 1.8 2 0 0 2 2 2 0 Acyl-ACP thioesterase Glyco_hydro_76 PF03663.14 EEA20142.1 - 1.9e-14 53.9 1.7 2.5e-14 53.6 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Complex1_LYR PF05347.15 EEA20143.1 - 3.1e-08 33.6 0.0 4.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EEA20143.1 - 1.8e-06 28.6 0.2 2.9e-06 27.9 0.2 1.4 1 1 0 1 1 1 1 Complex1_LYR-like Methyltransf_25 PF13649.6 EEA20144.1 - 5.7e-09 36.6 0.0 6.6e-08 33.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA20144.1 - 8.8e-06 26.3 0.0 3.4e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA20144.1 - 0.00029 20.7 0.0 0.00094 19.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA20144.1 - 0.003 17.3 0.0 0.008 16.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA20144.1 - 0.015 14.7 0.0 0.079 12.3 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Exo_endo_phos PF03372.23 EEA20145.1 - 6.5e-20 71.6 0.0 2.3e-19 69.9 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 EEA20145.1 - 7.5e-13 48.5 1.9 1.5e-06 28.4 0.6 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA20145.1 - 1.8e-12 46.8 7.3 6.4e-08 32.3 1.1 2.0 1 1 2 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EEA20145.1 - 4.3 8.3 4.4 1.7e+02 3.4 0.1 4.0 5 0 0 5 5 5 0 Leucine Rich Repeat Hydrolase_4 PF12146.8 EEA20146.1 - 1.7e-45 155.2 0.0 2.1e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA20146.1 - 3.3e-10 41.0 0.0 4.4e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA20146.1 - 4.6e-08 33.0 0.1 1.2e-07 31.6 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EEA20146.1 - 0.00016 20.6 0.0 0.00037 19.5 0.0 1.5 2 0 0 2 2 2 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 EEA20146.1 - 0.011 15.3 0.0 2.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Esterase PF00756.20 EEA20146.1 - 0.034 13.8 0.0 0.063 12.9 0.0 1.5 1 1 0 1 1 1 0 Putative esterase DUF1749 PF08538.10 EEA20146.1 - 0.035 13.2 0.0 0.062 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Abhydrolase_2 PF02230.16 EEA20146.1 - 0.13 12.1 0.0 50 3.6 0.0 3.1 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF915 PF06028.11 EEA20146.1 - 0.18 11.1 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) GCD14 PF08704.10 EEA20147.1 - 4.7e-06 26.5 0.0 0.0091 15.7 0.0 2.4 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 EEA20147.1 - 0.00053 19.8 0.3 0.0014 18.4 0.1 1.8 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_24 PF13578.6 EEA20147.1 - 0.018 16.0 0.1 0.14 13.2 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EEA20147.1 - 0.028 15.1 0.1 2.5 8.9 0.0 2.5 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_28 PF02636.17 EEA20147.1 - 0.074 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase HAD PF12710.7 EEA20148.1 - 1.6e-19 71.0 0.0 3.5e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Metallophos PF00149.28 EEA20148.1 - 2.4e-16 60.9 0.2 4.6e-16 59.9 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA20148.1 - 0.00021 21.5 0.0 0.0023 18.1 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Put_Phosphatase PF06888.12 EEA20148.1 - 0.12 11.8 0.0 10 5.4 0.0 2.4 2 0 0 2 2 2 0 Putative Phosphatase NAD_binding_1 PF00175.21 EEA20149.1 - 1.1e-05 26.1 0.0 0.16 12.7 0.0 2.7 3 0 0 3 3 3 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EEA20149.1 - 2.9e-05 24.2 0.0 7.8e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain MARVEL PF01284.23 EEA20150.1 - 4.4e-05 23.5 4.5 6.5e-05 23.0 4.5 1.3 1 0 0 1 1 1 1 Membrane-associating domain SUR7 PF06687.12 EEA20150.1 - 0.00014 21.6 1.5 0.0052 16.4 0.0 2.5 2 1 0 2 2 2 1 SUR7/PalI family Amidase PF01425.21 EEA20150.1 - 0.071 12.1 0.0 0.095 11.6 0.0 1.1 1 0 0 1 1 1 0 Amidase NEMP PF10225.9 EEA20150.1 - 0.4 10.3 3.5 0.51 10.0 0.0 2.3 2 0 0 2 2 2 0 NEMP family T5orf172 PF10544.9 EEA20151.1 - 3.5e-26 91.7 3.9 1.2e-24 86.8 0.1 3.2 3 0 0 3 3 3 2 T5orf172 domain MUG113 PF13455.6 EEA20151.1 - 3.1e-18 66.2 0.9 6.4e-16 58.8 0.3 2.7 2 0 0 2 2 2 2 Meiotically up-regulated gene 113 DNA_pol_phi PF04931.13 EEA20151.1 - 0.058 11.5 0.1 0.085 10.9 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi E1-E2_ATPase PF00122.20 EEA20152.1 - 5.3e-51 172.7 1.1 5.3e-51 172.7 1.1 2.3 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 EEA20152.1 - 3.8e-48 161.8 4.3 7.3e-12 45.6 0.1 4.9 5 0 0 5 5 5 4 Heavy-metal-associated domain Hydrolase PF00702.26 EEA20152.1 - 3.5e-36 125.5 0.6 8.7e-36 124.2 0.6 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EEA20152.1 - 5.9e-07 29.5 0.3 6.3e-05 22.8 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Transketolase_C PF02780.20 EEA20152.1 - 0.035 14.0 3.2 0.38 10.6 0.1 3.1 3 0 0 3 3 3 0 Transketolase, C-terminal domain HAD PF12710.7 EEA20152.1 - 0.041 14.3 0.1 0.13 12.6 0.1 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase EccE PF11203.8 EEA20152.1 - 0.076 13.3 1.4 8.1 6.8 0.0 4.3 6 0 0 6 6 6 0 Putative type VII ESX secretion system translocon, EccE PASTA PF03793.19 EEA20152.1 - 0.095 12.6 0.2 0.45 10.4 0.2 2.2 1 0 0 1 1 1 0 PASTA domain CDCA PF18484.1 EEA20152.1 - 0.099 12.5 1.6 4.4 7.1 0.3 2.8 2 1 1 3 3 3 0 Cadmium carbonic anhydrase repeat MpPF26 PF07666.11 EEA20152.1 - 0.25 11.4 2.6 5.9 7.0 0.2 2.6 2 0 0 2 2 2 0 M penetrans paralogue family 26 Rad1 PF02144.16 EEA20153.1 - 3.1e-88 295.4 0.0 3.6e-88 295.2 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Ost5 PF05251.12 EEA20154.1 - 5.2e-21 74.7 8.7 5.9e-21 74.5 8.7 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 DUF485 PF04341.12 EEA20154.1 - 0.021 14.8 2.7 0.025 14.5 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF485 CorA PF01544.18 EEA20154.1 - 3.2 7.0 4.8 3.5 6.8 4.8 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Bromodomain PF00439.25 EEA20155.1 - 7.9e-24 83.5 0.7 1.8e-23 82.4 0.7 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EEA20155.1 - 3.5e-08 33.7 0.0 6.9e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA20155.1 - 1e-06 28.7 0.0 2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA20155.1 - 0.00048 20.5 0.1 0.00088 19.7 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Bromodomain PF00439.25 EEA20156.1 - 7.8e-24 83.6 0.7 1.8e-23 82.4 0.7 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EEA20156.1 - 3.5e-08 33.7 0.0 6.8e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA20156.1 - 1e-06 28.7 0.0 2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA20156.1 - 0.00047 20.5 0.1 0.00087 19.7 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RGS PF00615.19 EEA20157.1 - 1.6e-12 47.7 0.0 3e-09 37.2 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain RGS PF00615.19 EEA20158.1 - 2.1e-12 47.4 0.0 3.4e-09 37.0 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain PCI PF01399.27 EEA20159.1 - 0.0032 18.0 0.0 0.0065 17.0 0.0 1.5 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 EEA20159.1 - 0.0098 15.8 0.3 0.016 15.1 0.3 1.3 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain AAA_23 PF13476.6 EEA20160.1 - 1e-36 127.3 3.2 1e-36 127.3 3.2 7.9 2 1 0 2 2 1 1 AAA domain SMC_N PF02463.19 EEA20160.1 - 8.6e-08 31.9 0.0 8.6e-08 31.9 0.0 3.4 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EEA20160.1 - 1.1e-07 31.9 65.9 0.00015 21.6 14.4 5.2 2 2 1 3 3 2 2 AAA ATPase domain AAA_21 PF13304.6 EEA20160.1 - 4.9e-07 29.9 13.5 0.0023 17.8 0.0 4.3 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EEA20160.1 - 2.1e-06 27.9 0.0 7.4e-06 26.1 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EEA20160.1 - 0.00068 19.3 0.0 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Img2 PF05046.14 EEA20160.1 - 0.0097 16.2 2.7 0.15 12.3 0.2 3.7 2 1 0 2 2 2 1 Mitochondrial large subunit ribosomal protein (Img2) AAA_13 PF13166.6 EEA20160.1 - 0.064 11.9 0.0 0.017 13.8 24.6 7.7 3 1 4 7 7 7 0 AAA domain AAA_16 PF13191.6 EEA20160.1 - 0.068 13.6 0.0 0.068 13.6 0.0 5.6 4 1 2 6 6 5 0 AAA ATPase domain ABC_tran PF00005.27 EEA20160.1 - 0.11 13.0 0.0 0.11 13.0 0.0 7.5 3 2 0 3 3 1 0 ABC transporter DUF3896 PF13035.6 EEA20160.1 - 0.5 10.6 0.0 0.5 10.6 0.0 5.5 5 1 1 6 6 6 0 Protein of unknown function (DUF3896) zf-RVT PF13966.6 EEA20161.1 - 0.0039 17.9 0.5 0.012 16.3 0.1 2.0 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase CNF1 PF05785.12 EEA20161.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Rho-activating domain of cytotoxic necrotizing factor RNase_H PF00075.24 EEA20161.1 - 0.12 12.6 0.1 0.29 11.3 0.1 1.7 1 1 0 1 1 1 0 RNase H GATA PF00320.27 EEA20162.1 - 1.3e-15 56.7 5.9 2.2e-15 56.0 5.9 1.4 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 EEA20162.1 - 2.5e-13 50.1 0.0 5.1e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EEA20162.1 - 2.3e-08 34.0 0.0 5.4e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EEA20162.1 - 2.1e-07 31.1 0.0 9.5e-07 29.0 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS_11 PF14598.6 EEA20162.1 - 7.5e-06 26.0 0.0 1.5e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EEA20162.1 - 1.3e-05 25.4 0.0 3.3e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 PAS fold Zn-ribbon_8 PF09723.10 EEA20162.1 - 0.0093 16.1 0.1 0.02 15.0 0.1 1.5 1 0 0 1 1 1 1 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 EEA20162.1 - 0.079 12.5 0.7 0.88 9.1 0.1 2.7 2 0 0 2 2 2 0 TFIIB zinc-binding FmdE PF02663.14 EEA20162.1 - 0.096 12.7 0.1 0.73 9.9 0.0 2.4 2 0 0 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon DUF4428 PF14471.6 EEA20162.1 - 0.13 12.2 2.1 0.14 12.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) PPP4R2 PF09184.11 EEA20163.1 - 4.3e-09 36.4 3.2 1.7e-08 34.5 3.2 2.2 1 1 0 1 1 1 1 PPP4R2 AIRC PF00731.20 EEA20164.1 - 4.1e-59 198.4 0.7 9.2e-59 197.3 0.7 1.6 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EEA20164.1 - 5.1e-53 179.1 0.0 1.1e-52 178.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EEA20164.1 - 4.6e-18 64.7 0.1 9.4e-18 63.7 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 EEA20164.1 - 1.9e-05 24.3 0.2 5.3e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PrpR_N PF06506.11 EEA20164.1 - 6.9e-05 22.5 0.4 0.0068 16.0 0.0 2.9 3 0 0 3 3 3 1 Propionate catabolism activator Dala_Dala_lig_C PF07478.13 EEA20164.1 - 9.6e-05 22.0 0.0 0.00057 19.5 0.0 2.1 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus AlaDh_PNT_C PF01262.21 EEA20164.1 - 0.001 18.4 0.0 0.0022 17.3 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EEA20164.1 - 0.0012 18.2 0.0 0.0023 17.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA20164.1 - 0.0048 16.8 0.1 0.014 15.3 0.1 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EEA20164.1 - 0.0094 16.1 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EEA20164.1 - 0.016 15.7 0.4 0.067 13.8 0.1 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent XdhC_C PF13478.6 EEA20164.1 - 0.055 14.0 0.1 0.29 11.6 0.0 2.1 2 0 0 2 2 2 0 XdhC Rossmann domain Peptidase_M15_3 PF08291.11 EEA20164.1 - 0.056 13.5 0.0 5.9 7.0 0.0 3.2 4 0 0 4 4 4 0 Peptidase M15 ATP-grasp_3 PF02655.14 EEA20164.1 - 0.06 13.4 0.1 0.21 11.6 0.0 2.1 1 1 1 2 2 2 0 ATP-grasp domain CoA_binding_2 PF13380.6 EEA20164.1 - 0.12 12.8 0.5 15 6.1 0.0 3.2 2 1 1 3 3 3 0 CoA binding domain Epimerase PF01370.21 EEA20164.1 - 0.12 11.8 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polyketide_cyc2 PF10604.9 EEA20165.1 - 0.23 11.7 4.3 1.5 9.1 4.3 2.3 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport DUF5082 PF16888.5 EEA20166.1 - 0.026 14.8 5.1 2.1 8.7 2.5 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF155 PF02582.14 EEA20167.1 - 1.1e-53 181.9 0.1 1.7e-53 181.3 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 CDC45 PF02724.14 EEA20167.1 - 0.2 9.9 3.4 0.29 9.4 3.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EEA20167.1 - 4.4 6.0 5.3 7.6 5.2 5.3 1.3 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 EEA20167.1 - 6.9 7.3 12.3 0.53 10.9 3.5 2.6 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C2H2 PF00096.26 EEA20168.1 - 4.4e-19 67.8 27.4 3.5e-05 24.0 1.7 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA20168.1 - 6.9e-17 61.0 23.9 1.4e-06 28.5 1.5 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA20168.1 - 2.9e-10 40.1 25.1 0.004 17.9 1.3 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA20168.1 - 1.3e-05 25.3 2.3 0.87 9.9 0.1 4.1 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EEA20168.1 - 0.00052 20.3 12.1 0.044 14.2 0.2 3.9 4 0 0 4 4 4 1 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EEA20168.1 - 0.0088 16.7 10.5 0.14 12.8 0.6 3.2 3 1 1 4 4 3 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EEA20168.1 - 0.015 15.4 0.4 2.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_11 PF16622.5 EEA20168.1 - 0.019 14.7 0.8 0.019 14.7 0.8 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-MYST PF17772.1 EEA20168.1 - 0.057 13.0 1.4 4.6 6.9 0.0 2.9 3 0 0 3 3 3 0 MYST family zinc finger domain zf_UBZ PF18439.1 EEA20168.1 - 0.15 11.7 2.2 1.1 8.9 0.2 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Yippee-Mis18 PF03226.14 EEA20168.1 - 0.32 11.2 2.1 16 5.7 0.1 2.3 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LIM PF00412.22 EEA20168.1 - 0.98 9.7 4.7 17 5.7 0.0 3.0 2 1 1 3 3 3 0 LIM domain C1_4 PF07975.12 EEA20168.1 - 1.3 9.3 5.8 1.1 9.6 0.2 2.7 1 1 2 3 3 3 0 TFIIH C1-like domain DUF4764 PF15961.5 EEA20168.1 - 9.3 4.8 8.2 0.68 8.6 0.2 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4764) Methyltransf_23 PF13489.6 EEA20169.1 - 2.6e-17 63.1 0.0 4.1e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA20169.1 - 1.5e-13 51.2 0.0 3.4e-13 50.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA20169.1 - 1e-11 45.4 0.0 3.5e-11 43.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA20169.1 - 4.1e-11 43.5 0.0 8.9e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA20169.1 - 1.9e-08 34.2 0.0 2.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EEA20169.1 - 0.0011 18.3 0.0 0.14 11.4 0.0 2.1 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase CheR PF01739.18 EEA20169.1 - 0.024 14.1 0.0 4.2 6.8 0.0 2.1 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Ubie_methyltran PF01209.18 EEA20169.1 - 0.086 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GFO_IDH_MocA PF01408.22 EEA20170.1 - 9.5e-22 78.1 0.1 1.6e-21 77.3 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EEA20170.1 - 0.026 15.2 0.0 0.05 14.3 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 EEA20170.1 - 0.07 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus E1-E2_ATPase PF00122.20 EEA20171.1 - 1.3e-40 138.9 14.7 4.6e-33 114.2 0.1 3.6 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EEA20171.1 - 7.4e-30 104.0 3.2 7.5e-30 104.0 0.3 2.3 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EEA20171.1 - 5.9e-23 80.8 0.6 1.2e-22 79.7 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EEA20171.1 - 1.1e-15 58.6 0.4 3.8e-14 53.5 0.4 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA20171.1 - 2.1e-13 49.8 0.0 6.1e-13 48.3 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EEA20171.1 - 5.4e-05 23.1 1.2 0.0094 15.7 0.8 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase SurA_N_3 PF13624.6 EEA20171.1 - 0.71 9.6 2.6 2 8.2 0.2 2.5 2 0 0 2 2 2 0 SurA N-terminal domain BRAP2 PF07576.12 EEA20172.1 - 9.9e-35 118.7 0.0 1.9e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EEA20172.1 - 4.8e-21 74.9 4.5 1.4e-20 73.4 4.5 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EEA20172.1 - 4.9e-08 33.2 9.5 4.9e-08 33.2 9.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA20172.1 - 1.5e-05 24.7 9.7 1.5e-05 24.7 9.7 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA20172.1 - 0.00044 20.1 5.1 0.00044 20.1 5.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA20172.1 - 0.00072 19.8 7.1 0.00072 19.8 7.1 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EEA20172.1 - 0.0011 18.6 5.7 0.0011 18.6 5.7 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EEA20172.1 - 0.0013 18.6 8.8 0.0013 18.6 8.8 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA20172.1 - 0.0017 18.3 6.0 0.0017 18.3 6.0 2.9 2 1 1 3 3 2 1 RING-type zinc-finger GIT_CC PF16559.5 EEA20172.1 - 0.002 17.9 3.9 0.039 13.8 1.2 2.5 2 0 0 2 2 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor zf-RING_5 PF14634.6 EEA20172.1 - 0.0023 17.9 7.9 0.0023 17.9 7.9 2.4 2 0 0 2 2 1 1 zinc-RING finger domain ZapB PF06005.12 EEA20172.1 - 0.0025 18.2 12.7 0.004 17.6 2.5 2.5 1 1 1 2 2 2 1 Cell division protein ZapB COG6 PF06419.11 EEA20172.1 - 0.0033 15.7 0.7 0.0066 14.7 0.7 1.5 1 1 0 1 1 1 1 Conserved oligomeric complex COG6 Spc29 PF17082.5 EEA20172.1 - 0.0095 15.8 0.5 0.029 14.2 0.5 1.8 1 0 0 1 1 1 1 Spindle Pole Component 29 zf-RING_6 PF14835.6 EEA20172.1 - 0.012 15.5 3.4 0.012 15.5 3.4 2.0 2 0 0 2 2 1 0 zf-RING of BARD1-type protein Cep57_MT_bd PF06657.13 EEA20172.1 - 0.014 15.8 1.5 1.2 9.7 0.4 3.0 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 zf-ANAPC11 PF12861.7 EEA20172.1 - 0.018 15.1 6.5 0.025 14.6 5.2 1.9 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger JAKMIP_CC3 PF16034.5 EEA20172.1 - 0.057 13.4 8.4 0.11 12.5 8.4 1.4 1 0 0 1 1 1 0 JAKMIP CC3 domain MIF4G_like_2 PF09090.11 EEA20172.1 - 0.19 11.2 6.9 0.32 10.4 6.9 1.3 1 0 0 1 1 1 0 MIF4G like Exonuc_VII_L PF02601.15 EEA20172.1 - 0.31 10.6 5.0 0.57 9.7 5.0 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALS2CR11 PF15729.5 EEA20172.1 - 0.36 9.9 3.8 0.15 11.2 0.7 1.6 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 Prok-RING_4 PF14447.6 EEA20172.1 - 0.44 10.5 21.3 0.023 14.6 8.9 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 TPR_MLP1_2 PF07926.12 EEA20172.1 - 3.2 7.8 19.8 6.8 6.8 19.8 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Striatin PF08232.12 EEA20172.1 - 5.3 7.6 16.9 0.39 11.3 9.4 2.4 2 0 0 2 2 2 0 Striatin family ubiquitin PF00240.23 EEA20173.1 - 4.4e-135 439.7 20.4 3.3e-33 113.3 0.6 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EEA20173.1 - 6.6e-64 211.7 21.0 2e-15 56.4 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA20173.1 - 8.1e-23 80.7 10.7 0.00043 20.7 0.1 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EEA20173.1 - 1.7e-16 59.9 3.0 0.027 14.4 0.0 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EEA20173.1 - 3e-15 56.3 7.7 0.029 14.7 0.1 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA20173.1 - 2.1e-14 53.6 2.6 0.12 12.4 0.0 5.0 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EEA20173.1 - 5.6e-13 49.3 1.4 0.37 11.4 0.0 4.2 1 1 1 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EEA20173.1 - 5.9e-11 42.5 0.8 0.6 9.9 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EEA20173.1 - 3.7e-07 30.1 24.0 16 5.6 0.2 8.0 8 0 0 8 8 8 0 Ubiquitin-like domain Methyltrans_RNA PF04452.14 EEA20173.1 - 3.1e-06 26.7 0.5 1.8 7.8 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase DUF3861 PF12977.7 EEA20173.1 - 3.8e-06 27.0 2.5 13 6.1 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 EEA20173.1 - 7.1e-06 26.3 0.0 30 5.1 0.0 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) ACT_5 PF13710.6 EEA20173.1 - 1.2e-05 25.0 4.7 10 6.1 0.0 4.3 4 0 0 4 4 4 0 ACT domain Big_7 PF17957.1 EEA20173.1 - 4e-05 24.3 0.1 52 4.7 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig domain UDP-g_GGTase PF06427.11 EEA20173.1 - 0.00014 21.9 4.3 7.1 6.8 0.0 4.0 4 0 0 4 4 4 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EEA20173.1 - 0.00043 19.8 0.0 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) YcgR_2 PF12945.7 EEA20173.1 - 0.00091 19.3 6.2 29 4.9 0.1 4.3 4 0 0 4 4 4 0 Flagellar protein YcgR DUF493 PF04359.14 EEA20173.1 - 0.003 18.1 0.1 1.4e+02 3.1 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF493) Raf1_HTH PF18579.1 EEA20173.1 - 0.0037 16.9 0.0 1e+02 2.7 0.0 4.1 4 0 0 4 4 4 0 Rubisco accumulation factor 1 helix turn helix domain ACT_4 PF13291.6 EEA20173.1 - 0.0052 17.4 1.0 1.4e+02 3.1 0.0 4.2 4 0 0 4 4 4 0 ACT domain ORF11CD3 PF10549.9 EEA20173.1 - 0.0068 16.5 0.0 91 3.3 0.0 4.3 4 0 0 4 4 4 0 ORF11CD3 domain ProRS-C_2 PF09181.10 EEA20173.1 - 0.11 12.7 5.8 1.1e+02 3.1 0.1 4.1 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal Baculo_p48 PF04878.13 EEA20173.1 - 0.12 11.2 0.0 61 2.4 0.0 3.0 3 0 0 3 3 3 0 Baculovirus P48 protein Tash_PEST PF07708.11 EEA20173.1 - 0.14 12.4 27.2 6.2 7.1 1.4 4.3 4 0 0 4 4 4 0 Tash protein PEST motif Myosin_N PF02736.19 EEA20173.1 - 0.23 11.3 6.3 1.1e+02 2.8 0.0 5.2 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain HAMP_N3 PF18575.1 EEA20173.1 - 0.23 11.0 1.5 2e+02 1.6 0.0 3.9 4 0 0 4 4 4 0 HAMP N-terminal domain 3 DMA PF03474.14 EEA20173.1 - 0.29 10.8 4.0 1e+02 2.6 0.0 4.1 4 0 0 4 4 4 0 DMRTA motif PI3K_p85B PF02192.16 EEA20173.1 - 1.9 8.3 9.3 96 2.8 0.1 4.2 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain Zn_clus PF00172.18 EEA20174.1 - 0.0033 17.5 7.7 0.0072 16.4 7.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SR-25 PF10500.9 EEA20174.1 - 0.97 9.0 14.5 1.8 8.1 14.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pap_E4 PF02711.14 EEA20174.1 - 4 8.5 8.7 12 6.9 8.7 1.8 1 0 0 1 1 1 0 E4 protein Prenyltrans PF00432.21 EEA20175.1 - 1e-38 130.8 18.6 2.7e-09 36.6 1.1 6.3 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EEA20175.1 - 0.012 14.8 0.0 0.65 9.0 0.0 2.5 2 1 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EEA20176.1 - 2.4e-32 110.3 13.9 1.7e-09 37.3 1.1 5.2 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat dsrm PF00035.26 EEA20177.1 - 0.046 14.4 0.0 0.1 13.3 0.0 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EEA20177.1 - 0.17 12.2 0.3 0.38 11.0 0.3 1.6 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 MCU PF04678.13 EEA20178.1 - 2.2e-26 93.0 0.4 2.2e-26 93.0 0.4 2.3 2 1 0 2 2 2 1 Mitochondrial calcium uniporter DUF1281 PF06924.11 EEA20178.1 - 0.0075 15.8 0.5 0.016 14.8 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1281) Hpt PF01627.23 EEA20179.1 - 2.7e-13 50.0 0.1 4.7e-13 49.2 0.1 1.4 1 0 0 1 1 1 1 Hpt domain DUF19 PF01579.18 EEA20179.1 - 0.014 15.2 0.6 0.022 14.6 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF19) Hpt PF01627.23 EEA20180.1 - 2.7e-13 50.0 0.1 4.7e-13 49.2 0.1 1.4 1 0 0 1 1 1 1 Hpt domain DUF19 PF01579.18 EEA20180.1 - 0.014 15.2 0.6 0.022 14.6 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF19) Aminotran_1_2 PF00155.21 EEA20181.1 - 2e-91 306.9 0.0 2.4e-91 306.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SART-1 PF03343.13 EEA20182.1 - 6.8e-189 629.5 59.9 7.8e-189 629.3 59.9 1.0 1 0 0 1 1 1 1 SART-1 family Phage_fiber_2 PF03406.13 EEA20182.1 - 0.12 12.0 0.3 0.97 9.0 0.0 2.5 2 0 0 2 2 2 0 Phage tail fibre repeat Phage_lysozyme PF00959.19 EEA20182.1 - 3.1 8.3 6.4 0.3 11.5 0.8 2.1 2 1 0 2 2 2 0 Phage lysozyme PTH2 PF01981.16 EEA20183.1 - 6.6e-43 145.7 0.1 8.9e-43 145.3 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 FAM176 PF14851.6 EEA20183.1 - 0.16 11.6 2.1 0.28 10.9 2.1 1.3 1 0 0 1 1 1 0 FAM176 family Treacle PF03546.14 EEA20183.1 - 0.41 9.4 5.1 0.73 8.6 5.1 1.3 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle DNA_pol_phi PF04931.13 EEA20183.1 - 2.7 6.0 5.4 3.3 5.7 5.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi HMGL-like PF00682.19 EEA20185.1 - 1.5e-78 264.0 0.3 2.2e-78 263.5 0.3 1.2 1 0 0 1 1 1 1 HMGL-like Endonuc-BglII PF09195.11 EEA20185.1 - 0.085 12.7 0.0 0.43 10.4 0.0 2.0 2 0 0 2 2 2 0 Restriction endonuclease BglII Pyridoxal_deC PF00282.19 EEA20186.1 - 9.8e-19 67.3 0.0 1.6e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EEA20186.1 - 1.3e-05 24.3 0.0 7.1e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EEA20186.1 - 0.0025 17.2 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Ribosomal_L30 PF00327.20 EEA20187.1 - 6.1e-12 45.2 0.3 8.2e-12 44.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Sec6 PF06046.13 EEA20188.1 - 1.1e-172 575.5 8.7 1.5e-172 575.0 8.7 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Laminin_II PF06009.12 EEA20188.1 - 0.073 13.1 1.8 0.13 12.3 0.4 2.0 1 1 1 2 2 2 0 Laminin Domain II Vps53_N PF04100.12 EEA20188.1 - 0.11 11.4 8.3 0.35 9.8 2.5 2.5 2 0 0 2 2 2 0 Vps53-like, N-terminal LprI PF07007.12 EEA20188.1 - 5.2 7.8 8.7 0.37 11.5 0.2 3.3 3 1 1 4 4 4 0 Lysozyme inhibitor LprI FadA PF09403.10 EEA20188.1 - 8.2 7.0 9.4 23 5.6 1.3 3.1 2 1 0 2 2 2 0 Adhesion protein FadA Glyco_hydro_16 PF00722.21 EEA20189.1 - 1.1e-18 67.3 0.3 6e-18 64.9 0.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 EEA20189.1 - 8.1e-06 24.5 3.1 0.0016 17.0 0.1 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) HsbA PF12296.8 EEA20190.1 - 1.6e-22 80.2 0.0 2e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Hydrophobic surface binding protein A AKAP7_NLS PF10469.9 EEA20191.1 - 9.4e-19 68.1 0.0 1.8e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Frataxin_Cyay PF01491.16 EEA20192.1 - 4.6e-35 120.0 0.0 7e-35 119.4 0.0 1.3 1 0 0 1 1 1 1 Frataxin-like domain zf-CSL PF05207.13 EEA20193.1 - 4.8e-22 77.4 0.6 6.3e-22 77.1 0.6 1.2 1 0 0 1 1 1 1 CSL zinc finger HAUS4 PF14735.6 EEA20194.1 - 1.9e-10 40.9 1.2 4e-10 39.8 1.2 1.6 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 4 Mucin PF01456.17 EEA20194.1 - 0.00031 20.8 18.5 0.0007 19.6 18.5 1.6 1 0 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.12 EEA20194.1 - 0.011 13.8 8.7 0.0037 15.3 6.0 1.6 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EEA20194.1 - 0.021 14.8 15.3 0.039 13.9 15.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FSA_C PF10479.9 EEA20194.1 - 0.058 11.5 8.3 0.09 10.9 8.3 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FAM199X PF15814.5 EEA20194.1 - 1.7 7.6 8.9 1.1 8.3 4.1 2.1 2 0 0 2 2 2 0 Protein family FAM199X Bromodomain PF00439.25 EEA20195.1 - 3.9e-40 135.8 0.6 5.6e-19 68.0 0.1 2.6 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 EEA20195.1 - 1.5e-18 66.7 2.4 2.9e-18 65.8 1.5 2.1 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation Sin3_corepress PF08295.12 EEA20195.1 - 0.093 12.8 1.5 0.26 11.4 1.5 1.7 1 0 0 1 1 1 0 Sin3 family co-repressor V_ATPase_I PF01496.19 EEA20195.1 - 0.98 7.3 5.3 1.4 6.7 5.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF722 PF05263.11 EEA20195.1 - 2.9 8.1 5.6 0.34 11.1 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF722) DUF3573 PF12097.8 EEA20195.1 - 4.3 6.1 7.3 6.6 5.5 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Utp12 PF04003.12 EEA20196.1 - 2.8e-22 79.1 0.0 4.7e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF3157 PF11355.8 EEA20196.1 - 0.004 16.8 0.2 0.56 9.8 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3157) SDA1 PF05285.12 EEA20196.1 - 2 7.7 44.8 1.7 8.0 26.9 2.4 2 0 0 2 2 2 0 SDA1 Drc1-Sld2 PF11719.8 EEA20196.1 - 2.4 7.6 26.9 2.3 7.7 3.6 2.3 2 0 0 2 2 2 0 DNA replication and checkpoint protein WD40 PF00400.32 EEA20197.1 - 6.3e-10 39.5 6.4 0.00028 21.6 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20197.1 - 2.8e-05 24.3 0.3 0.78 10.1 0.0 3.7 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PPTA PF01239.22 EEA20198.1 - 8e-35 117.6 17.4 3.6e-08 32.9 0.1 5.8 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF1016_N PF17761.1 EEA20198.1 - 0.029 14.5 1.0 0.029 14.5 1.0 2.1 2 1 0 2 2 2 0 DUF1016 N-terminal domain PhoD_N PF16655.5 EEA20198.1 - 0.04 14.4 0.2 0.11 13.0 0.0 1.8 2 0 0 2 2 2 0 PhoD-like phosphatase, N-terminal domain VIT1 PF01988.19 EEA20198.1 - 0.51 10.2 2.1 3.1 7.6 0.4 2.1 2 0 0 2 2 2 0 VIT family RabGAP-TBC PF00566.18 EEA20199.1 - 1.3e-49 168.8 5.7 1.8e-49 168.3 0.2 2.9 2 1 0 2 2 2 1 Rab-GTPase-TBC domain YabA PF06156.13 EEA20199.1 - 0.13 12.9 19.0 2 9.1 4.1 3.1 1 1 1 2 2 2 0 Initiation control protein YabA SHE3 PF17078.5 EEA20199.1 - 0.2 11.3 15.9 0.4 10.4 15.9 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 HALZ PF02183.18 EEA20199.1 - 2.2 8.6 4.6 1.1 9.6 0.4 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper UPF0242 PF06785.11 EEA20199.1 - 3.4 7.7 24.1 7.1 6.7 23.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cnn_1N PF07989.11 EEA20199.1 - 7.5 6.8 28.6 0.19 11.9 7.5 3.2 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Mago_nashi PF02792.14 EEA20199.1 - 9.5 6.3 8.5 0.38 10.8 0.7 2.1 1 1 1 2 2 2 0 Mago nashi protein RabGAP-TBC PF00566.18 EEA20200.1 - 9.8e-50 169.2 5.0 1.8e-49 168.3 0.2 2.9 2 1 0 2 2 2 1 Rab-GTPase-TBC domain UPF0242 PF06785.11 EEA20200.1 - 0.3 11.2 20.1 0.84 9.7 20.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 EEA20200.1 - 2.1 9.0 18.7 3.6 8.3 4.9 2.8 1 1 1 2 2 2 0 Initiation control protein YabA HALZ PF02183.18 EEA20200.1 - 2.4 8.4 4.6 1 9.6 0.4 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper Mago_nashi PF02792.14 EEA20200.1 - 5.4 7.1 7.4 0.39 10.8 0.7 2.1 1 1 1 2 2 2 0 Mago nashi protein Cnn_1N PF07989.11 EEA20200.1 - 7 6.9 28.3 0.16 12.2 7.3 3.1 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Dabb PF07876.12 EEA20201.1 - 3.6e-11 43.5 0.0 4.5e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Chalcone_N PF18232.1 EEA20201.1 - 0.0027 18.1 0.0 0.0041 17.5 0.0 1.4 1 0 0 1 1 1 1 Chalcone isomerase N-terminal domain Ctf8 PF09696.10 EEA20202.1 - 2.8e-45 154.1 0.0 3.8e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Ctf8 Cnl2_NKP2 PF09447.10 EEA20204.1 - 1.9e-26 92.0 1.4 3.4e-26 91.2 1.4 1.4 1 0 0 1 1 1 1 Cnl2/NKP2 family protein MRG PF05712.13 EEA20205.1 - 8.6e-59 198.2 2.5 1.2e-58 197.7 2.5 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EEA20205.1 - 3e-10 39.8 2.7 6.4e-10 38.8 2.7 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 EEA20205.1 - 0.00048 20.0 1.6 0.0014 18.4 1.6 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PWWP PF00855.17 EEA20205.1 - 0.008 16.6 0.1 0.02 15.3 0.1 1.6 1 0 0 1 1 1 1 PWWP domain MRG PF05712.13 EEA20206.1 - 4e-59 199.3 2.5 4.9e-59 199.0 2.5 1.0 1 0 0 1 1 1 1 MRG DUF1741 PF08427.10 EEA20207.1 - 1.6e-89 299.6 0.1 2.7e-89 298.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Fe-S_biosyn PF01521.20 EEA20208.1 - 5.9e-21 74.7 0.0 9.7e-21 74.1 0.0 1.4 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF2407_C PF13373.6 EEA20209.1 - 1.8e-42 144.8 0.1 1.8e-42 144.8 0.1 1.6 2 0 0 2 2 2 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EEA20209.1 - 1.8e-35 121.6 0.6 2.8e-35 121.0 0.0 1.6 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EEA20209.1 - 1.8e-05 24.4 0.0 3.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 EEA20209.1 - 0.013 15.6 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like V-SNARE PF05008.15 EEA20210.1 - 2.7e-22 78.9 5.5 2.7e-22 78.9 5.5 2.0 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EEA20210.1 - 4.3e-18 65.3 6.1 4.3e-18 65.3 6.1 2.6 3 1 0 3 3 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EEA20210.1 - 0.00058 19.7 0.3 0.00058 19.7 0.3 2.2 2 2 1 3 3 3 1 Sec20 Thump_like PF18096.1 EEA20210.1 - 0.0017 18.2 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 THUMP domain-like Prominin PF05478.11 EEA20210.1 - 0.0044 15.1 2.1 0.31 8.9 0.2 2.1 2 0 0 2 2 2 2 Prominin DUF4407 PF14362.6 EEA20210.1 - 0.018 14.4 11.0 0.032 13.6 11.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fusion_gly PF00523.18 EEA20210.1 - 0.019 13.3 1.2 0.047 12.0 0.1 2.0 2 0 0 2 2 2 0 Fusion glycoprotein F0 LPP PF04728.13 EEA20210.1 - 0.047 14.1 0.4 3.6 8.1 0.0 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Exonuc_VII_L PF02601.15 EEA20210.1 - 0.89 9.1 14.4 12 5.4 14.5 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit Synaptobrevin PF00957.21 EEA20210.1 - 1.3 8.9 7.9 0.22 11.3 1.8 2.7 2 1 1 3 3 3 0 Synaptobrevin YqjK PF13997.6 EEA20210.1 - 3.6 7.9 11.6 0.43 10.9 0.2 3.3 3 1 0 3 3 3 0 YqjK-like protein DUF4083 PF13314.6 EEA20210.1 - 4.3 7.4 8.5 17 5.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) FAM76 PF16046.5 EEA20210.1 - 5 6.4 5.5 0.88 8.9 1.1 1.8 2 0 0 2 2 2 0 FAM76 protein zf-C4H2 PF10146.9 EEA20210.1 - 7.8 6.7 8.7 81 3.4 8.7 2.3 1 1 0 1 1 1 0 Zinc finger-containing protein V-SNARE PF05008.15 EEA20211.1 - 2.7e-22 78.9 5.5 2.7e-22 78.9 5.5 2.0 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EEA20211.1 - 3.7e-18 65.6 4.8 3.7e-18 65.6 4.8 2.6 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Thump_like PF18096.1 EEA20211.1 - 0.0018 18.2 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 THUMP domain-like DHC_N1 PF08385.12 EEA20211.1 - 0.048 12.3 0.6 0.062 11.9 0.6 1.3 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 LPP PF04728.13 EEA20211.1 - 0.048 14.0 0.4 3.6 8.1 0.0 2.5 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Prominin PF05478.11 EEA20211.1 - 0.063 11.2 1.4 0.31 8.9 0.2 1.9 2 0 0 2 2 2 0 Prominin Sec20 PF03908.13 EEA20211.1 - 0.64 10.0 2.7 0.59 10.1 0.2 2.2 2 2 1 3 3 3 0 Sec20 Exonuc_VII_L PF02601.15 EEA20211.1 - 0.83 9.2 13.8 7.9 5.9 13.8 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EEA20211.1 - 2.1 7.6 12.5 4 6.7 12.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) YqjK PF13997.6 EEA20211.1 - 3.7 7.9 10.7 0.78 10.0 0.1 3.3 3 1 0 3 3 3 0 YqjK-like protein zf-C4H2 PF10146.9 EEA20211.1 - 8.2 6.7 8.7 80 3.4 8.7 2.2 1 1 0 1 1 1 0 Zinc finger-containing protein TIP49 PF06068.13 EEA20212.1 - 1.1e-163 544.5 0.0 1.3e-163 544.3 0.0 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EEA20212.1 - 2.9e-23 81.7 0.0 1.6e-22 79.4 0.0 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EEA20212.1 - 5.1e-11 43.1 0.2 3.4e-07 30.7 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA20212.1 - 5.6e-10 39.2 0.0 1.3e-06 28.3 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA20212.1 - 9.5e-05 22.7 0.1 0.39 11.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EEA20212.1 - 0.00079 19.9 0.2 0.0061 17.0 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EEA20212.1 - 0.00087 19.7 1.2 0.064 13.6 0.3 2.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA20212.1 - 0.00092 19.2 0.1 0.19 11.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EEA20212.1 - 0.0023 18.2 0.1 0.0048 17.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EEA20212.1 - 0.0023 17.6 0.1 1.2 8.8 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain Zeta_toxin PF06414.12 EEA20212.1 - 0.0063 15.8 0.2 0.014 14.7 0.2 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 EEA20212.1 - 0.008 15.8 0.2 0.019 14.6 0.1 1.6 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EEA20212.1 - 0.023 14.1 0.1 0.77 9.1 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 EEA20212.1 - 0.053 12.8 0.0 0.075 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EEA20212.1 - 0.054 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EEA20212.1 - 0.061 12.7 0.1 0.15 11.3 0.1 1.6 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 EEA20212.1 - 0.097 13.2 0.0 0.35 11.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 EEA20212.1 - 0.098 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_7 PF12775.7 EEA20212.1 - 0.13 11.8 0.2 0.44 10.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Ribosomal_L28 PF00830.19 EEA20213.1 - 3.7e-15 55.9 1.3 8.3e-15 54.7 1.3 1.5 1 0 0 1 1 1 1 Ribosomal L28 family Glyco_transf_34 PF05637.12 EEA20214.1 - 5.2e-63 213.0 0.0 7.2e-63 212.5 0.0 1.0 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF4407 PF14362.6 EEA20214.1 - 0.23 10.8 0.4 0.32 10.3 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Steroid_dh PF02544.16 EEA20215.1 - 2.9e-31 108.5 0.2 4.1e-31 108.0 0.2 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 EEA20215.1 - 0.00068 20.0 0.2 0.0015 18.9 0.2 1.6 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 EEA20215.1 - 0.0044 16.6 0.1 0.0066 16.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF913 PF06025.12 EEA20216.1 - 1.6e-131 438.6 0.0 1.6e-131 438.6 0.0 5.6 5 1 0 5 5 5 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EEA20216.1 - 4.4e-109 365.2 9.0 1.3e-108 363.6 9.0 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) HECT PF00632.25 EEA20216.1 - 6.3e-95 318.2 0.0 2.3e-94 316.3 0.0 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EEA20216.1 - 2.7e-29 99.7 24.9 3.8e-11 42.0 2.4 4.6 4 0 0 4 4 4 3 Ubiquitin binding region V-ATPase_H_N PF03224.14 EEA20216.1 - 0.12 11.7 0.7 0.78 9.0 0.0 2.7 2 0 0 2 2 2 0 V-ATPase subunit H UBA PF00627.31 EEA20216.1 - 0.14 12.1 0.4 0.81 9.7 0.1 2.5 2 0 0 2 2 2 0 UBA/TS-N domain Pribosyltran_N PF13793.6 EEA20217.1 - 2.8e-45 153.0 1.7 1.3e-43 147.6 0.1 2.4 2 1 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EEA20217.1 - 2e-41 142.0 5.7 1.5e-35 122.9 1.5 2.6 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EEA20217.1 - 7.3e-19 67.8 0.8 3e-17 62.6 0.4 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EEA20217.1 - 7.2e-05 22.3 0.3 0.00015 21.3 0.3 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Ribosomal_S6e PF01092.19 EEA20218.1 - 2.5e-56 189.0 0.1 6.5e-56 187.7 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein S6e HMG_box PF00505.19 EEA20220.1 - 1.6e-22 79.7 0.6 2.8e-22 78.9 0.6 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA20220.1 - 3.3e-08 34.0 0.3 7e-08 32.9 0.3 1.6 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 EEA20220.1 - 0.048 13.0 0.0 0.098 12.0 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SNF2_N PF00176.23 EEA20221.1 - 2.5e-41 141.5 0.0 5.5e-36 124.0 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA20221.1 - 6.5e-07 29.7 0.0 1.4e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UPF0184 PF03670.13 EEA20221.1 - 0.046 14.1 0.1 0.15 12.5 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) AAA_18 PF13238.6 EEA20223.1 - 0.0036 17.9 0.0 0.028 15.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EEA20223.1 - 0.0041 16.2 0.0 0.052 12.6 0.0 2.2 2 1 1 3 3 3 1 Type II/IV secretion system protein PRK PF00485.18 EEA20223.1 - 0.0045 16.7 0.0 0.0064 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 EEA20223.1 - 0.011 16.2 0.0 0.02 15.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EEA20223.1 - 0.012 16.1 0.1 0.049 14.1 0.1 1.9 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EEA20223.1 - 0.1 12.8 0.0 0.37 10.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 EEA20223.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein MobB PF03205.14 EEA20223.1 - 0.14 12.0 0.0 0.34 10.8 0.0 1.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DIM1 PF02966.16 EEA20224.1 - 6.5e-67 223.4 0.1 7.4e-67 223.2 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EEA20224.1 - 0.1 12.6 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin PTS_IIA PF02255.16 EEA20225.1 - 0.026 14.6 0.3 0.049 13.7 0.3 1.4 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit RNase_J_C PF17770.1 EEA20225.1 - 0.16 13.0 0.4 7.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain Ald_Xan_dh_C2 PF02738.18 EEA20227.1 - 1.1e-203 677.7 3.2 1.5e-203 677.2 3.2 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EEA20227.1 - 3e-46 157.3 0.0 6.3e-46 156.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 EEA20227.1 - 4e-34 117.3 0.0 8.3e-34 116.3 0.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 EEA20227.1 - 2.9e-31 107.7 0.0 2.9e-30 104.5 0.0 2.8 3 0 0 3 3 3 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EEA20227.1 - 2.4e-29 101.1 0.0 5.5e-29 100.0 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EEA20227.1 - 1.2e-07 31.5 2.5 1.3e-07 31.4 0.1 2.3 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain Baculo_PEP_C PF04513.12 EEA20228.1 - 4.1 7.4 21.9 3.4 7.7 6.3 3.9 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Collagen_mid PF15984.5 EEA20228.1 - 4.9 6.9 10.5 0.24 11.1 0.1 3.2 4 0 0 4 4 4 0 Bacterial collagen, middle region IMS PF00817.20 EEA20229.1 - 4.5e-39 133.8 0.0 8.9e-39 132.9 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EEA20229.1 - 1.8e-14 54.4 0.1 4.4e-14 53.2 0.1 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EEA20229.1 - 0.0043 17.3 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif HHH_5 PF14520.6 EEA20229.1 - 0.075 13.6 0.0 0.23 12.1 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain zf_UBZ PF18439.1 EEA20229.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger CCDC106 PF15794.5 EEA20230.1 - 0.086 12.5 5.2 0.13 11.9 5.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CDC45 PF02724.14 EEA20230.1 - 0.32 9.2 9.3 0.34 9.1 8.4 1.4 2 0 0 2 2 2 0 CDC45-like protein MFMR_assoc PF16596.5 EEA20230.1 - 3.4 8.1 16.8 0.82 10.1 11.0 2.3 2 0 0 2 2 2 0 Disordered region downstream of MFMR NAM-associated PF14303.6 EEA20230.1 - 5 7.8 13.2 2.1 9.0 10.1 1.9 1 1 1 2 2 2 0 No apical meristem-associated C-terminal domain Serum_albumin PF00273.20 EEA20231.1 - 0.012 15.4 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Serum albumin family Tri3 PF07428.11 EEA20232.1 - 9.7e-05 21.4 0.1 0.0058 15.6 0.0 2.1 1 1 0 2 2 2 2 15-O-acetyltransferase Tri3 SUa-2TM PF18179.1 EEA20232.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 SMODS- and Ubiquitin system-associated 2TM effector domain Condensation PF00668.20 EEA20232.1 - 0.19 10.3 0.1 0.55 8.8 0.0 1.7 2 0 0 2 2 2 0 Condensation domain Cupin_2 PF07883.11 EEA20234.1 - 1.7e-07 30.8 0.0 3.7e-07 29.8 0.0 1.6 1 1 1 2 2 2 1 Cupin domain Cupin_1 PF00190.22 EEA20234.1 - 0.0015 18.2 0.0 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 Cupin Reprolysin_5 PF13688.6 EEA20236.1 - 1.5e-61 208.0 6.3 1.5e-61 208.0 6.3 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EEA20236.1 - 1.3e-49 168.6 1.7 2.5e-49 167.7 1.7 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EEA20236.1 - 1.1e-46 159.2 2.4 2.7e-46 157.9 2.4 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 EEA20236.1 - 1.1e-16 61.4 31.2 1.1e-16 61.4 31.2 4.4 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 EEA20236.1 - 6.2e-10 39.7 0.5 2.2e-09 37.9 0.0 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 EEA20236.1 - 3.4e-06 27.5 12.1 3.4e-06 27.5 12.1 4.3 1 1 2 3 3 3 1 ADAM cysteine-rich domain Pep_M12B_propep PF01562.19 EEA20236.1 - 0.0023 18.1 0.0 0.0047 17.2 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Peptidase_M66 PF10462.9 EEA20236.1 - 0.093 11.7 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase M66 EF-hand_7 PF13499.6 EEA20237.1 - 1.6e-16 60.5 2.5 2.6e-10 40.6 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EEA20237.1 - 4.4e-15 54.0 0.7 1.4e-05 24.3 0.0 3.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EEA20237.1 - 7.8e-14 50.4 4.5 6.7e-06 25.6 0.1 3.8 4 1 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EEA20237.1 - 5e-11 42.3 3.4 1.6e-08 34.2 0.2 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA20237.1 - 0.0017 17.8 1.1 1.5 8.4 0.1 3.3 3 0 0 3 3 3 2 EF hand DUF3572 PF12096.8 EEA20237.1 - 0.041 14.1 0.0 1 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3572) EF-hand_4 PF12763.7 EEA20237.1 - 0.047 13.6 0.0 0.13 12.2 0.0 1.7 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 EEA20237.1 - 0.17 12.0 0.1 0.57 10.3 0.0 1.9 2 0 0 2 2 2 0 Ca2+ insensitive EF hand DUF5560 PF17715.1 EEA20237.1 - 8.4 5.8 13.7 0.18 11.3 5.5 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5560) MgsA_C PF12002.8 EEA20238.1 - 1.8e-58 197.2 0.1 3.2e-58 196.4 0.1 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EEA20238.1 - 8e-23 80.6 0.4 3.4e-22 78.6 0.1 2.2 2 0 0 2 2 2 1 AAA C-terminal domain AAA PF00004.29 EEA20238.1 - 2.2e-12 47.5 0.1 6.1e-12 46.1 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA20238.1 - 2e-09 37.4 0.0 3.6e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EEA20238.1 - 1.8e-05 24.2 0.2 0.019 14.4 0.0 2.4 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EEA20238.1 - 0.00043 20.3 0.3 0.016 15.2 0.1 2.8 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EEA20238.1 - 0.00092 18.9 0.1 0.061 13.0 0.1 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EEA20238.1 - 0.0012 18.9 0.0 0.0028 17.8 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 EEA20238.1 - 0.0021 18.5 0.1 0.54 10.6 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_3 PF07726.11 EEA20238.1 - 0.0052 16.6 0.0 0.054 13.3 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EEA20238.1 - 0.0098 15.6 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EEA20238.1 - 0.015 14.5 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 EEA20238.1 - 0.019 15.3 0.3 0.039 14.3 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA20238.1 - 0.031 14.6 0.0 0.087 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EEA20238.1 - 0.037 14.0 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EEA20238.1 - 0.052 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EEA20238.1 - 0.054 12.7 0.0 0.093 11.9 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain NB-ARC PF00931.22 EEA20238.1 - 0.21 10.7 0.1 0.51 9.5 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 EEA20238.1 - 0.22 11.2 0.5 0.47 10.1 0.1 1.7 2 0 0 2 2 2 0 AAA domain zf-Di19 PF05605.12 EEA20238.1 - 0.29 11.5 1.0 0.56 10.5 1.0 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding ResIII PF04851.15 EEA20238.1 - 0.31 11.0 2.9 6 6.8 0.0 2.7 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit MGC-24 PF05283.11 EEA20238.1 - 2.5 8.5 5.5 6.1 7.3 5.5 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Zn_clus PF00172.18 EEA20239.1 - 0.19 11.9 12.5 0.35 11.0 12.5 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-RING_4 PF14570.6 EEA20239.1 - 0.19 11.5 7.6 0.49 10.2 7.6 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Aminotran_1_2 PF00155.21 EEA20240.1 - 4.1e-71 240.1 0.0 4.7e-71 239.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA20240.1 - 0.00014 20.5 0.0 0.00025 19.7 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EEA20240.1 - 0.0045 16.3 0.0 0.0067 15.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EEA20240.1 - 0.022 13.7 0.0 0.047 12.6 0.0 1.5 1 1 0 1 1 1 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EEA20240.1 - 0.057 12.7 0.0 0.23 10.7 0.0 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family C2 PF00168.30 EEA20241.1 - 7.1e-29 100.1 0.0 3e-16 59.6 0.0 2.6 2 0 0 2 2 2 2 C2 domain GET2 PF08690.10 EEA20242.1 - 1.7e-17 64.1 3.3 9.4e-17 61.6 0.5 2.6 1 1 1 2 2 2 1 GET complex subunit GET2 AMP-binding PF00501.28 EEA20243.1 - 4.4e-88 295.7 0.1 5.3e-88 295.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA20243.1 - 1.7e-27 96.2 0.2 9.4e-26 90.6 0.2 2.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EEA20243.1 - 1.3e-16 60.3 0.1 3.4e-16 58.9 0.1 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Nup96 PF12110.8 EEA20244.1 - 3.5e-81 272.5 0.6 5.3e-81 271.9 0.6 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EEA20244.1 - 2.2e-51 173.9 0.0 3.4e-51 173.3 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EEA20244.1 - 3.2e-10 40.7 81.9 1.3e-07 32.4 39.9 10.3 3 2 5 9 9 9 4 Nucleoporin FG repeat region MFS_1 PF07690.16 EEA20245.1 - 8.2e-49 166.4 23.8 8.2e-49 166.4 23.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20245.1 - 5e-08 32.2 2.9 5e-08 32.2 2.9 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter LapA_dom PF06305.11 EEA20245.1 - 0.42 10.5 9.6 0.43 10.4 0.2 3.9 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain OATP PF03137.20 EEA20245.1 - 0.72 8.1 12.3 0.011 14.1 3.0 2.5 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Complex1_51K PF01512.17 EEA20246.1 - 1.5e-47 161.2 0.0 2.5e-47 160.5 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EEA20246.1 - 2.1e-29 101.4 0.3 4.3e-29 100.4 0.3 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EEA20246.1 - 7.3e-09 35.4 0.0 1.9e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 SLBB domain DUF3568 PF12092.8 EEA20246.1 - 0.11 12.6 0.3 0.19 11.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) SET PF00856.28 EEA20247.1 - 0.0018 18.7 0.0 0.0064 16.9 0.0 2.0 2 0 0 2 2 2 1 SET domain SAPS PF04499.15 EEA20248.1 - 1.4e-199 664.0 3.0 1.4e-199 664.0 3.0 2.7 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein Snf7 PF03357.21 EEA20249.1 - 1.3e-43 148.6 14.6 1.6e-43 148.3 14.6 1.0 1 0 0 1 1 1 1 Snf7 DUF4201 PF13870.6 EEA20249.1 - 0.0019 18.0 7.9 0.0024 17.6 6.9 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4201) bZIP_1 PF00170.21 EEA20249.1 - 0.0027 17.8 3.6 1.9 8.6 0.0 3.1 2 1 0 3 3 3 2 bZIP transcription factor Zwint PF15556.6 EEA20249.1 - 0.0043 16.6 4.9 0.0064 16.0 4.9 1.3 1 0 0 1 1 1 1 ZW10 interactor Alpha-2-MRAP_C PF06401.11 EEA20249.1 - 0.0069 16.4 2.9 0.012 15.5 2.3 1.7 1 1 0 1 1 1 1 Alpha-2-macroglobulin RAP, C-terminal domain NPV_P10 PF05531.12 EEA20249.1 - 0.016 15.6 6.2 0.71 10.4 1.0 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein CLZ PF16526.5 EEA20249.1 - 0.04 14.3 5.0 4.9 7.6 0.0 3.3 1 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HHH_2 PF12826.7 EEA20249.1 - 0.043 13.9 0.0 0.093 12.8 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Prefoldin_2 PF01920.20 EEA20249.1 - 0.05 13.6 6.7 1.1 9.2 0.0 3.2 2 1 0 2 2 2 0 Prefoldin subunit FlaC_arch PF05377.11 EEA20249.1 - 0.083 13.3 6.7 5.6 7.4 0.0 3.4 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) FAM199X PF15814.5 EEA20249.1 - 0.1 11.6 1.9 0.15 11.1 1.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X DUF4844 PF16133.5 EEA20249.1 - 0.15 12.6 2.7 0.45 11.1 2.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4844) FapA PF03961.13 EEA20249.1 - 0.47 9.0 7.5 3.4 6.2 7.5 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A EMC3_TMCO1 PF01956.16 EEA20249.1 - 8.4 6.1 11.5 6.3 6.5 6.1 2.1 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Nramp PF01566.18 EEA20250.1 - 3.9e-92 309.0 18.0 7.2e-92 308.1 18.0 1.4 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Drf_GBD PF06371.13 EEA20251.1 - 1.6e-17 63.7 2.5 3.9e-16 59.2 2.5 2.4 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain FAD_binding_3 PF01494.19 EEA20252.1 - 3.5e-14 52.8 9.2 3.8e-13 49.4 9.2 2.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA20252.1 - 3.3e-06 26.5 0.3 0.00062 19.1 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA20252.1 - 2.2e-05 24.6 0.4 5.4e-05 23.3 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EEA20252.1 - 0.00025 20.2 0.0 0.042 12.9 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase Amino_oxidase PF01593.24 EEA20252.1 - 0.00047 19.6 0.6 0.065 12.5 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EEA20252.1 - 0.00086 19.3 2.7 0.9 9.5 1.7 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EEA20252.1 - 0.0011 18.1 0.1 0.0016 17.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA20252.1 - 0.0035 17.0 6.2 0.0062 16.2 4.8 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EEA20252.1 - 0.047 12.8 0.1 0.086 11.9 0.1 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 EEA20252.1 - 0.087 12.1 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EEA20252.1 - 0.094 11.4 0.9 0.16 10.7 0.9 1.3 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EEA20252.1 - 0.29 9.9 4.4 3.9 6.2 0.0 2.7 3 0 0 3 3 3 0 Tryptophan halogenase Pyr_redox PF00070.27 EEA20252.1 - 1.5 9.5 3.3 1.8 9.2 1.8 2.1 2 1 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA20252.1 - 1.9 7.4 5.6 22 4.0 0.0 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein MFS_1 PF07690.16 EEA20254.1 - 1.4e-14 53.9 40.8 1.4e-14 53.9 40.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20254.1 - 6.1e-07 28.7 12.2 6.1e-07 28.7 12.2 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter HET PF06985.11 EEA20255.1 - 1.4e-14 54.6 3.0 2e-12 47.7 0.1 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) RTX_C PF08339.10 EEA20256.1 - 0.25 11.4 1.2 0.37 10.8 1.2 1.2 1 0 0 1 1 1 0 RTX C-terminal domain Thiolase_N PF00108.23 EEA20257.1 - 6.7e-76 255.1 1.0 6.7e-76 255.1 1.0 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA20257.1 - 6.1e-44 148.6 0.2 1.4e-43 147.5 0.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EEA20257.1 - 0.0076 15.9 1.8 0.041 13.4 0.6 2.6 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Cadherin_tail PF15974.5 EEA20257.1 - 0.1 12.9 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region ACP_syn_III PF08545.10 EEA20257.1 - 0.11 12.3 1.0 17 5.4 0.0 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III BLM10_mid PF16507.5 EEA20258.1 - 4e-213 708.8 0.0 7.6e-213 707.9 0.0 1.5 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EEA20258.1 - 3e-30 104.0 0.0 3.4e-29 100.6 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EEA20258.1 - 1.5e-20 73.3 0.1 6.1e-20 71.3 0.0 2.1 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, N-terminal CLASP_N PF12348.8 EEA20258.1 - 0.0023 17.5 1.0 2 7.9 0.0 4.0 3 1 1 4 4 4 2 CLASP N terminal HEAT PF02985.22 EEA20258.1 - 0.012 15.8 0.1 13 6.4 0.0 4.9 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 EEA20258.1 - 0.046 14.2 0.0 35 5.1 0.0 4.4 3 0 0 3 3 3 0 HEAT-like repeat Mannosyl_trans2 PF04188.13 EEA20259.1 - 2.6e-52 178.6 17.2 3.3e-52 178.3 17.2 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) HTH_50 PF18024.1 EEA20259.1 - 0.096 12.3 0.7 0.42 10.3 0.3 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain Mannosyl_trans2 PF04188.13 EEA20260.1 - 2.8e-32 112.6 7.9 3.1e-32 112.4 7.9 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) AAA_27 PF13514.6 EEA20260.1 - 0.23 11.0 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Pro_CA PF00484.19 EEA20262.1 - 1.4e-41 142.4 0.0 1.7e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Zn_clus PF00172.18 EEA20263.1 - 0.00011 22.2 8.0 0.00046 20.2 8.0 2.1 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA20264.1 - 8.9e-17 61.0 0.5 1.3e-16 60.5 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20264.1 - 3.7e-08 33.4 11.7 6.6e-08 32.6 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 EEA20264.1 - 0.012 14.1 0.4 0.02 13.4 0.4 1.2 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B CENP-B_dimeris PF09026.10 EEA20264.1 - 1.2 9.5 11.3 3.2 8.2 11.3 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 EEA20264.1 - 9.8 5.2 10.5 22 4.0 10.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Velvet PF11754.8 EEA20265.1 - 1.1e-45 156.5 8.3 8e-33 114.4 0.3 2.6 2 1 1 3 3 3 2 Velvet factor SPR1 PF15356.6 EEA20265.1 - 0.028 14.9 5.2 0.06 13.9 1.7 2.3 1 1 1 2 2 2 0 Psoriasis susceptibility locus 2 Velvet PF11754.8 EEA20266.1 - 1.2e-45 156.5 8.3 8.1e-33 114.4 0.3 2.6 2 1 1 3 3 3 2 Velvet factor SPR1 PF15356.6 EEA20266.1 - 0.027 15.0 5.2 0.061 13.8 1.7 2.4 1 1 1 2 2 2 0 Psoriasis susceptibility locus 2 MOZ_SAS PF01853.18 EEA20267.1 - 6.3e-75 250.8 0.0 9.6e-75 250.2 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EEA20267.1 - 4.8e-21 74.1 3.3 1.1e-20 73.0 3.3 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 EEA20267.1 - 6.6e-12 45.4 8.6 2.8e-11 43.3 8.0 2.4 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EEA20267.1 - 0.035 14.0 14.1 0.013 15.3 10.0 2.2 2 0 0 2 2 2 0 PHD-finger MWFE PF15879.5 EEA20268.1 - 6.6e-26 90.2 0.1 8.2e-26 89.9 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit RraA-like PF03737.15 EEA20269.1 - 7.4e-26 91.1 0.2 1e-25 90.7 0.2 1.2 1 0 0 1 1 1 1 Aldolase/RraA NTP_transf_3 PF12804.7 EEA20269.1 - 0.046 14.1 0.0 0.097 13.0 0.0 1.5 1 0 0 1 1 1 0 MobA-like NTP transferase domain RraA-like PF03737.15 EEA20270.1 - 1.3e-22 80.6 0.1 3e-21 76.1 0.1 2.1 1 1 0 1 1 1 1 Aldolase/RraA RraA-like PF03737.15 EEA20271.1 - 8.6e-22 77.9 0.3 2.6e-20 73.1 0.3 2.1 1 1 0 1 1 1 1 Aldolase/RraA V_ATPase_I PF01496.19 EEA20272.1 - 0 1068.6 0.0 0 1068.4 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Filament PF00038.21 EEA20272.1 - 0.02 14.5 2.3 3.4 7.2 0.1 2.2 2 0 0 2 2 2 0 Intermediate filament protein DUF1218 PF06749.12 EEA20272.1 - 0.049 14.2 2.3 0.17 12.4 2.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) CheZ PF04344.13 EEA20272.1 - 0.057 13.3 0.7 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ PIF2 PF04631.12 EEA20272.1 - 0.088 11.6 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Per os infectivity factor 2 DASH_Dam1 PF08653.10 EEA20272.1 - 0.1 12.5 0.6 36 4.2 0.0 3.9 4 0 0 4 4 4 0 DASH complex subunit Dam1 CdvA PF18822.1 EEA20272.1 - 0.54 10.1 2.0 20 5.0 0.1 3.1 3 0 0 3 3 3 0 CdvA-like coiled-coil domain Prefoldin_2 PF01920.20 EEA20272.1 - 2.8 7.9 4.1 13 5.8 0.3 2.9 2 1 0 3 3 3 0 Prefoldin subunit FBPase PF00316.20 EEA20273.1 - 7.4e-68 227.7 0.0 1e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Lectin_N PF03954.14 EEA20274.1 - 0.2 11.4 5.0 0.39 10.5 2.6 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain AAA_23 PF13476.6 EEA20274.1 - 1.2 9.6 9.3 3.5 8.1 9.3 1.8 1 0 0 1 1 1 0 AAA domain Aha1_N PF09229.11 EEA20275.1 - 3.7e-41 140.5 1.5 8e-41 139.5 1.5 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EEA20275.1 - 4.4e-19 68.9 1.0 7.9e-19 68.1 1.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Mucin PF01456.17 EEA20275.1 - 3.1 7.8 13.8 4.6 7.2 7.4 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Aha1_N PF09229.11 EEA20276.1 - 4.7e-41 140.2 2.4 6.1e-41 139.8 1.5 1.7 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EEA20276.1 - 3.3e-19 69.3 1.0 6.1e-19 68.5 1.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Aha1_N PF09229.11 EEA20277.1 - 2.4e-41 141.1 1.5 5.6e-41 139.9 1.5 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EEA20277.1 - 3e-19 69.5 1.0 5.7e-19 68.6 1.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Aha1_N PF09229.11 EEA20278.1 - 2.4e-41 141.1 1.5 5.6e-41 139.9 1.5 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EEA20278.1 - 3e-19 69.5 1.0 5.7e-19 68.6 1.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Sacchrp_dh_C PF16653.5 EEA20279.1 - 2.6e-92 309.7 0.0 4.1e-92 309.0 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EEA20279.1 - 3e-25 89.0 1.2 4.6e-25 88.4 1.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EEA20279.1 - 5.2e-07 29.8 0.4 1.1e-06 28.8 0.4 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EEA20279.1 - 2.5e-06 27.5 0.5 4.6e-06 26.6 0.5 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_7 PF13241.6 EEA20279.1 - 2.8e-05 24.5 0.4 7.8e-05 23.1 0.4 1.7 2 0 0 2 2 1 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 EEA20279.1 - 8.3e-05 22.0 1.0 0.00013 21.3 1.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Epimerase PF01370.21 EEA20279.1 - 0.00047 19.7 0.1 0.0013 18.3 0.1 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_3 PF03447.16 EEA20279.1 - 0.0025 18.5 1.4 0.0044 17.7 1.4 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain NmrA PF05368.13 EEA20279.1 - 0.0027 17.3 0.6 0.0043 16.6 0.6 1.3 1 0 0 1 1 1 1 NmrA-like family GFO_IDH_MocA PF01408.22 EEA20279.1 - 0.0084 16.9 0.1 0.014 16.2 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EEA20279.1 - 0.0085 16.5 0.2 0.016 15.6 0.2 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain IlvN PF07991.12 EEA20279.1 - 0.01 15.4 0.9 0.029 13.9 0.4 1.9 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EEA20279.1 - 0.02 15.2 1.1 0.037 14.3 1.1 1.4 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 EEA20279.1 - 0.056 12.8 0.1 0.13 11.6 0.1 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EEA20279.1 - 0.11 11.4 0.1 0.19 10.7 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ppx-GppA PF02541.16 EEA20280.1 - 3.5e-40 138.2 0.0 2.2e-39 135.6 0.0 2.0 1 1 0 1 1 1 1 Ppx/GppA phosphatase family Semialdhyde_dhC PF02774.18 EEA20280.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain Prenyltransf PF01255.19 EEA20281.1 - 8.4e-79 264.2 0.0 1.4e-78 263.5 0.0 1.3 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Acyltransferase PF01553.21 EEA20282.1 - 2.5e-09 36.9 0.0 0.00079 19.1 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase PRA-PH PF01503.17 EEA20282.1 - 0.011 16.1 0.2 0.058 13.8 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase UCR_hinge PF02320.16 EEA20283.1 - 1.4e-25 89.2 5.9 1.4e-25 89.2 5.9 2.0 2 0 0 2 2 1 1 Ubiquinol-cytochrome C reductase hinge protein Vps36_ESCRT-II PF11605.8 EEA20283.1 - 0.00083 19.5 0.0 0.012 15.7 0.0 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 CobT PF06213.12 EEA20283.1 - 0.0021 17.5 16.5 0.0039 16.6 16.5 1.4 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Mpp10 PF04006.12 EEA20283.1 - 0.007 14.9 15.0 0.013 14.0 15.0 1.3 1 0 0 1 1 1 1 Mpp10 protein SAPS PF04499.15 EEA20283.1 - 0.045 12.6 1.2 0.053 12.3 1.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein bPH_3 PF14470.6 EEA20283.1 - 0.047 14.0 0.0 0.083 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial PH domain GRAM PF02893.20 EEA20283.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 GRAM domain RR_TM4-6 PF06459.12 EEA20283.1 - 0.2 11.5 13.4 0.055 13.3 10.4 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Folliculin PF11704.8 EEA20283.1 - 0.43 10.4 5.0 0.88 9.4 0.0 2.9 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport RNA_pol_3_Rpc31 PF11705.8 EEA20283.1 - 0.48 10.7 15.0 0.14 12.4 10.7 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 EEA20283.1 - 0.86 8.9 13.6 1.5 8.1 13.6 1.3 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 EEA20283.1 - 2 7.1 13.1 4 6.1 13.1 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Merozoite_SPAM PF07133.11 EEA20283.1 - 2.4 8.1 30.3 4.5 7.2 30.3 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CPSF100_C PF13299.6 EEA20283.1 - 2.5 8.3 7.0 7.1 6.8 7.0 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.12 EEA20283.1 - 3.4 5.8 18.0 4.9 5.2 18.0 1.1 1 0 0 1 1 1 0 Nop14-like family SpoIIP PF07454.11 EEA20283.1 - 4.3 6.7 8.6 1.1 8.7 5.6 1.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RNA_pol_Rpc4 PF05132.14 EEA20283.1 - 5.3 7.5 9.6 0.43 11.0 4.4 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 Prothymosin PF03247.14 EEA20283.1 - 5.3 7.5 33.3 14 6.1 33.3 1.7 1 0 0 1 1 1 0 Prothymosin/parathymosin family SDA1 PF05285.12 EEA20283.1 - 6.6 6.1 18.9 1.7 8.0 15.5 1.6 2 0 0 2 2 2 0 SDA1 MFS_1 PF07690.16 EEA20284.1 - 1.4e-28 99.8 31.6 1.4e-28 99.8 31.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EEA20284.1 - 3.8e-09 35.6 1.2 3.8e-09 35.6 1.2 2.6 2 1 1 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 EEA20284.1 - 1e-05 24.6 2.0 1e-05 24.6 2.0 2.8 1 1 3 4 4 4 2 MFS_1 like family DUF2798 PF11391.8 EEA20284.1 - 0.042 13.9 3.3 0.49 10.5 0.3 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) Glyco_hydro_12 PF01670.16 EEA20285.1 - 9.5e-53 179.4 11.3 1.4e-50 172.3 11.3 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 Uds1 PF15456.6 EEA20286.1 - 5.6e-43 146.2 1.7 5.6e-43 146.2 1.7 6.2 4 2 2 6 6 6 2 Up-regulated During Septation APG6_N PF17675.1 EEA20286.1 - 0.014 15.9 9.8 0.014 15.9 9.8 7.2 3 2 3 6 6 6 0 Apg6 coiled-coil region WXG100 PF06013.12 EEA20286.1 - 0.03 14.6 1.1 0.03 14.6 1.1 6.6 6 1 1 8 8 8 0 Proteins of 100 residues with WXG DUF4407 PF14362.6 EEA20286.1 - 3.2 7.0 59.0 0.47 9.7 24.1 4.5 1 1 1 4 4 4 0 Domain of unknown function (DUF4407) WD40 PF00400.32 EEA20287.1 - 7.9e-31 105.6 8.1 0.00013 22.7 0.1 8.3 9 0 0 9 9 9 5 WD domain, G-beta repeat F-box-like PF12937.7 EEA20287.1 - 4e-12 45.8 0.3 1.1e-11 44.4 0.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA20287.1 - 1.5e-08 34.3 0.0 3.8e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EEA20287.1 - 0.0004 20.6 0.6 1.2 9.4 0.0 3.6 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA20287.1 - 0.005 16.2 0.1 1.2 8.4 0.0 2.4 2 0 0 2 2 2 2 WD40-like domain MgtE_N PF03448.17 EEA20287.1 - 0.096 13.3 0.0 0.23 12.1 0.0 1.5 1 0 0 1 1 1 0 MgtE intracellular N domain PALB2_WD40 PF16756.5 EEA20287.1 - 0.11 11.4 0.0 0.52 9.2 0.0 1.9 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain PH_10 PF15411.6 EEA20288.1 - 8e-41 139.2 0.0 2.1e-40 137.8 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain CDC24 PF06395.11 EEA20288.1 - 1.3e-35 121.5 0.0 2.4e-35 120.6 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 EEA20288.1 - 2.6e-22 79.9 1.4 4.1e-22 79.3 1.4 1.3 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 EEA20288.1 - 1.2e-08 34.8 0.1 2.3e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 EEA20288.1 - 0.062 13.8 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 PH domain Aminotran_1_2 PF00155.21 EEA20289.1 - 2.4e-34 119.1 0.0 2.8e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_1_2 PF00155.21 EEA20290.1 - 2.4e-34 119.1 0.0 2.8e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II NICE-3 PF07406.11 EEA20291.1 - 0.0015 18.6 0.0 1.5 8.8 0.0 2.2 2 0 0 2 2 2 2 NICE-3 protein DUF4129 PF13559.6 EEA20291.1 - 0.018 15.3 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) Suc_Fer-like PF06999.12 EEA20292.1 - 2.5e-69 233.1 0.0 3e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like GCFC PF07842.12 EEA20293.1 - 3.8e-85 285.9 7.6 3.8e-85 285.9 7.6 1.6 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EEA20293.1 - 4.9e-16 58.4 2.6 1.2e-15 57.2 2.6 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EEA20293.1 - 2.3e-07 30.8 2.3 1e-06 28.7 2.3 2.1 1 0 0 1 1 1 1 G-patch domain Sod_Fe_C PF02777.18 EEA20294.1 - 4.1e-36 123.2 0.4 6e-36 122.7 0.4 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EEA20294.1 - 7.1e-28 96.9 0.5 1.2e-27 96.2 0.5 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.18 EEA20295.1 - 4.1e-36 123.2 0.4 6e-36 122.7 0.4 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EEA20295.1 - 7.1e-28 96.9 0.5 1.2e-27 96.2 0.5 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain NTP_transferase PF00483.23 EEA20296.1 - 1.2e-52 179.0 0.0 2.4e-52 178.0 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EEA20296.1 - 1.3e-14 53.3 6.7 3.4e-11 42.4 1.7 3.1 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EEA20296.1 - 1.6e-09 38.3 0.0 2.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EEA20296.1 - 1.4e-06 27.9 6.9 1.9e-06 27.5 0.9 3.0 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EEA20296.1 - 0.028 12.6 0.2 0.047 11.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) SRP54 PF00448.22 EEA20296.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain IspD PF01128.19 EEA20296.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MFS_1 PF07690.16 EEA20297.1 - 3.8e-32 111.6 73.9 3.9e-25 88.5 34.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20297.1 - 4.2e-12 45.7 32.5 1.3e-06 27.6 8.8 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter REPA_OB_2 PF16900.5 EEA20298.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Replication protein A OB domain NopRA1 PF16201.5 EEA20299.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 REPA_OB_2 PF16900.5 EEA20299.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Replication protein A OB domain Peptidase_M41 PF01434.18 EEA20300.1 - 4.1e-57 193.1 0.4 7.8e-57 192.2 0.4 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EEA20300.1 - 1.6e-42 145.0 0.0 4.2e-42 143.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA20300.1 - 1e-12 47.6 0.0 2.7e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EEA20300.1 - 8.1e-06 25.9 0.0 2.4e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EEA20300.1 - 4.9e-05 22.7 0.1 0.00013 21.3 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 EEA20300.1 - 5.2e-05 23.7 0.8 0.00059 20.3 0.8 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA20300.1 - 0.00018 21.8 1.6 0.029 14.7 0.2 3.1 3 1 0 3 3 2 1 AAA domain RuvB_N PF05496.12 EEA20300.1 - 0.00031 20.5 0.0 0.00092 19.0 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EEA20300.1 - 0.0038 17.4 0.0 0.014 15.6 0.0 2.1 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EEA20300.1 - 0.0085 15.3 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EEA20300.1 - 0.011 15.5 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 EEA20300.1 - 0.016 15.3 0.0 0.049 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EEA20300.1 - 0.025 14.0 0.2 0.05 13.0 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EEA20300.1 - 0.027 14.0 2.4 0.59 9.7 0.3 2.4 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA20300.1 - 0.035 14.7 0.0 0.093 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EEA20300.1 - 0.051 12.9 0.1 1.5 8.1 0.0 2.6 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 EEA20300.1 - 0.055 13.4 0.4 1.8 8.4 0.1 2.7 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 EEA20300.1 - 0.072 13.3 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EEA20300.1 - 0.087 13.3 0.3 0.25 11.8 0.0 1.9 2 0 0 2 2 1 0 AAA domain SpoU_sub_bind PF08032.12 EEA20300.1 - 0.11 12.8 0.3 20 5.6 0.5 2.7 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding AAA_7 PF12775.7 EEA20300.1 - 0.16 11.5 0.1 0.45 10.0 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region FGGY_C PF02782.16 EEA20301.1 - 1.8e-74 249.8 1.1 2.9e-74 249.1 1.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EEA20301.1 - 3.7e-61 206.8 0.0 5e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EEA20301.1 - 0.044 13.3 1.0 4.3 6.7 0.0 2.3 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Pro-kuma_activ PF09286.11 EEA20301.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Pro-kumamolisin, activation domain DUF3429 PF11911.8 EEA20302.1 - 1.5e-43 148.6 10.1 2.4e-43 147.8 10.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) SHR-BD PF06650.12 EEA20303.1 - 8.3e-100 333.6 0.0 4.2e-98 328.1 0.0 3.2 3 1 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 EEA20303.1 - 4e-92 307.9 14.8 2.1e-89 299.0 1.0 5.7 5 0 0 5 5 5 2 Repeating coiled region of VPS13 VPS13 PF16908.5 EEA20303.1 - 3.9e-81 272.3 0.7 6e-79 265.2 0.0 4.3 6 0 0 6 6 6 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 EEA20303.1 - 1.2e-71 240.2 8.1 4.9e-69 231.7 0.2 2.9 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EEA20303.1 - 1.5e-40 137.9 0.0 6.3e-40 135.9 0.0 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EEA20303.1 - 8.6e-07 29.2 0.0 5e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF896 PF05979.12 EEA20303.1 - 0.063 13.2 5.7 0.9 9.4 0.3 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) zf-C2H2 PF00096.26 EEA20304.1 - 1.8e-17 62.8 33.5 5.7e-05 23.4 3.3 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA20304.1 - 6.5e-15 54.8 28.3 3.9e-06 27.1 1.0 5.2 5 1 1 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA20304.1 - 1.9e-05 25.1 36.8 0.064 14.1 2.7 4.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EEA20304.1 - 0.016 15.5 11.1 0.055 13.8 5.6 3.1 1 1 1 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 EEA20304.1 - 0.019 15.6 12.1 0.76 10.5 0.2 4.2 2 1 2 4 4 4 0 FOXP coiled-coil domain zf-tcix PF14952.6 EEA20304.1 - 0.71 9.5 4.2 4.1 7.1 0.2 2.9 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding zf-C2H2_jaz PF12171.8 EEA20304.1 - 0.74 10.2 7.5 36 4.8 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding TFIIA PF03153.13 EEA20304.1 - 2 8.3 11.8 2.3 8.1 11.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-met PF12874.7 EEA20304.1 - 2.3 8.7 13.8 13 6.3 0.5 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-CGNR PF11706.8 EEA20304.1 - 5.5 6.9 15.0 0.78 9.6 0.5 4.1 4 0 0 4 4 4 0 CGNR zinc finger zf-C2H2 PF00096.26 EEA20305.1 - 9.7e-18 63.6 33.5 4.8e-05 23.6 3.3 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA20305.1 - 1.1e-15 57.2 26.9 3.3e-06 27.3 1.0 5.3 5 1 1 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA20305.1 - 1e-05 25.9 36.8 0.054 14.3 2.7 4.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EEA20305.1 - 0.0073 16.6 10.6 0.03 14.6 5.1 3.1 1 1 1 2 2 2 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 EEA20305.1 - 0.0099 16.5 12.1 0.64 10.7 0.2 4.3 2 1 2 4 4 4 1 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 EEA20305.1 - 0.42 11.0 7.5 31 5.0 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-tcix PF14952.6 EEA20305.1 - 0.49 10.1 4.2 3.5 7.3 0.2 2.9 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding zf-met PF12874.7 EEA20305.1 - 1.3 9.5 13.8 11 6.5 0.5 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type TFIIA PF03153.13 EEA20305.1 - 4.1 7.3 12.9 4.5 7.2 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-C2H2 PF00096.26 EEA20306.1 - 1.1e-17 63.4 33.5 5e-05 23.5 3.3 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA20306.1 - 1.4e-15 56.9 27.0 3.4e-06 27.2 1.0 5.2 5 1 1 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA20306.1 - 1.2e-05 25.7 36.8 0.056 14.3 2.7 4.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EEA20306.1 - 0.0081 16.4 10.6 0.043 14.1 5.3 3.1 1 1 1 2 2 2 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 EEA20306.1 - 0.011 16.3 12.0 0.67 10.6 0.2 4.3 2 1 2 4 4 4 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 EEA20306.1 - 0.48 10.8 7.5 32 5.0 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-tcix PF14952.6 EEA20306.1 - 0.53 9.9 4.2 3.7 7.3 0.2 2.9 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding zf-met PF12874.7 EEA20306.1 - 1.5 9.3 13.8 12 6.5 0.5 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type TFIIA PF03153.13 EEA20306.1 - 2.2 8.2 12.2 2.5 8.0 12.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_67M PF07488.12 EEA20307.1 - 1.1e-147 491.3 0.1 1.7e-147 490.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 EEA20307.1 - 1.5e-90 302.7 3.3 2.2e-90 302.1 3.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.14 EEA20307.1 - 1e-29 103.3 0.0 2e-29 102.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.15 EEA20307.1 - 0.037 14.8 0.0 0.11 13.3 0.0 1.8 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 adh_short PF00106.25 EEA20308.1 - 2.1e-10 40.4 0.0 3.4e-07 29.9 0.0 3.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA20308.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 KR domain adh_short_C2 PF13561.6 EEA20308.1 - 0.17 11.4 0.0 3.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Cnn_1N PF07989.11 EEA20309.1 - 7.3e-10 38.9 13.0 2.5e-09 37.1 13.0 2.0 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 MAD PF05557.13 EEA20309.1 - 0.0007 18.1 12.0 0.001 17.6 12.0 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Prominin PF05478.11 EEA20309.1 - 0.033 12.1 1.1 0.048 11.6 1.1 1.1 1 0 0 1 1 1 0 Prominin G-gamma PF00631.22 EEA20309.1 - 0.053 13.5 1.2 0.17 11.9 1.2 1.9 1 0 0 1 1 1 0 GGL domain AAA_23 PF13476.6 EEA20309.1 - 0.11 13.0 9.4 0.24 11.9 9.4 1.5 1 0 0 1 1 1 0 AAA domain DUF4666 PF15697.5 EEA20309.1 - 0.11 13.2 0.3 0.11 13.2 0.3 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4666) YabA PF06156.13 EEA20309.1 - 0.47 11.1 11.4 0.68 10.6 9.9 2.0 1 1 0 1 1 1 0 Initiation control protein YabA UPF0242 PF06785.11 EEA20309.1 - 0.5 10.4 12.9 1.3 9.1 12.9 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fzo_mitofusin PF04799.13 EEA20309.1 - 0.52 9.8 3.0 1.1 8.8 3.0 1.5 1 0 0 1 1 1 0 fzo-like conserved region HemX PF04375.14 EEA20309.1 - 0.63 9.3 7.7 0.72 9.1 3.3 2.3 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Seadorna_VP6 PF07407.11 EEA20309.1 - 0.7 8.8 2.7 5.6 5.8 3.5 1.8 2 0 0 2 2 2 0 Seadornavirus VP6 protein Exonuc_VII_L PF02601.15 EEA20309.1 - 1.7 8.1 9.3 3.7 7.0 9.3 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 EEA20309.1 - 7.3 6.7 8.3 14 5.8 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Sld5 PF05916.11 EEA20310.1 - 1.8e-22 79.9 0.0 2.4e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein Sld5 PF05916.11 EEA20311.1 - 8.8e-14 51.9 0.0 1.3e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein PNP_UDP_1 PF01048.20 EEA20312.1 - 1.1e-08 34.6 0.0 1.3e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Ank_2 PF12796.7 EEA20313.1 - 2.7e-40 136.8 6.0 8.7e-11 42.3 0.0 6.5 4 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA20313.1 - 7.8e-33 112.4 3.9 8.8e-09 35.7 0.0 8.2 5 3 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA20313.1 - 4.3e-29 97.3 2.0 0.0036 17.7 0.0 10.2 9 0 0 9 9 9 5 Ankyrin repeat Ank PF00023.30 EEA20313.1 - 1.7e-26 91.4 10.6 0.0036 17.7 0.0 10.1 10 0 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 EEA20313.1 - 2.5e-20 72.3 1.7 0.00012 22.3 0.0 7.9 7 1 1 8 8 8 3 Ankyrin repeats (many copies) NACHT PF05729.12 EEA20313.1 - 1.7e-07 31.3 0.1 4.5e-07 29.9 0.0 1.8 2 0 0 2 2 1 1 NACHT domain AAA_22 PF13401.6 EEA20313.1 - 0.00034 20.9 0.0 0.0008 19.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EEA20313.1 - 0.00078 18.8 1.2 0.43 9.8 0.1 2.3 1 1 1 2 2 2 2 KAP family P-loop domain AAA_30 PF13604.6 EEA20313.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA20313.1 - 0.0019 18.6 0.0 0.0053 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EEA20313.1 - 0.0063 16.9 0.0 0.016 15.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 EEA20313.1 - 0.0092 16.0 0.0 0.033 14.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EEA20313.1 - 0.012 16.1 0.0 0.035 14.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Ploopntkinase3 PF18751.1 EEA20313.1 - 0.023 14.6 0.0 0.065 13.1 0.0 1.7 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA PF00004.29 EEA20313.1 - 0.062 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EEA20313.1 - 0.064 13.8 0.0 0.2 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EEA20313.1 - 0.076 12.9 0.0 0.28 11.0 0.0 2.0 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_11 PF13086.6 EEA20313.1 - 0.13 12.1 0.0 0.75 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EEA20313.1 - 0.14 11.9 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EEA20313.1 - 0.17 11.1 0.2 0.56 9.4 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain DUF1843 PF08898.10 EEA20313.1 - 1.1 9.8 3.5 2.4 8.7 0.2 3.2 3 1 1 4 4 3 0 Domain of unknown function (DUF1843) RVT_2 PF07727.14 EEA20314.1 - 3.7e-38 131.6 0.2 7.3e-38 130.6 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA20314.1 - 2.4e-07 30.5 0.0 5.7e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA20314.1 - 0.00069 19.8 0.0 0.0016 18.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA20314.1 - 0.029 13.9 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA20314.1 - 0.09 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA20314.1 - 0.14 12.5 3.2 0.37 11.1 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein PNP_UDP_1 PF01048.20 EEA20315.1 - 0.066 12.4 0.1 0.15 11.3 0.1 1.5 1 1 0 1 1 1 0 Phosphorylase superfamily DDE_Tnp_1_7 PF13843.6 EEA20317.1 - 1.2e-49 169.5 0.2 2e-49 168.8 0.2 1.3 1 0 0 1 1 1 1 Transposase IS4 DUF3974 PF13120.6 EEA20317.1 - 0.1 12.7 0.2 0.56 10.3 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3974) LRRC37 PF15779.5 EEA20317.1 - 4.8 7.6 6.2 6.9 7.1 0.9 3.0 3 0 0 3 3 3 0 Leucine-rich repeat-containing protein 37 family Transket_pyr PF02779.24 EEA20320.1 - 2.8e-64 216.1 0.0 4.9e-64 215.3 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EEA20320.1 - 3.9e-59 200.1 0.0 5.7e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EEA20320.1 - 4.5e-57 192.0 0.0 7.5e-57 191.3 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EEA20320.1 - 3.2e-20 71.4 0.6 7.1e-20 70.3 0.6 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus DUF2680 PF10925.8 EEA20320.1 - 0.063 13.3 0.3 0.55 10.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2680) ING PF12998.7 EEA20321.1 - 1.6e-11 44.7 0.1 6.4e-11 42.7 0.1 2.0 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EEA20321.1 - 5.7e-06 26.1 7.2 9.8e-06 25.4 7.2 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EEA20321.1 - 0.023 15.0 2.5 0.054 13.8 2.5 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain DUF4378 PF14309.6 EEA20321.1 - 0.061 13.7 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) zf-HC5HC2H_2 PF13832.6 EEA20321.1 - 0.12 12.5 1.9 0.26 11.5 1.9 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain PHD_2 PF13831.6 EEA20321.1 - 0.2 11.2 1.6 0.34 10.5 1.6 1.4 1 0 0 1 1 1 0 PHD-finger F-box-like PF12937.7 EEA20322.1 - 1.9e-05 24.5 0.2 5.7e-05 22.9 0.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA20322.1 - 0.053 13.4 2.9 0.56 10.2 0.9 3.6 3 1 0 3 3 3 0 F-box domain LRR_6 PF13516.6 EEA20322.1 - 0.14 12.2 5.7 16 5.8 0.0 4.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.7 EEA20322.1 - 0.7 10.4 13.1 2.9 8.4 0.3 4.8 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) BSD PF03909.17 EEA20323.1 - 4.4e-30 103.5 11.3 3e-15 56.0 0.8 3.2 3 0 0 3 3 3 2 BSD domain PH_TFIIH PF08567.11 EEA20323.1 - 1.8e-27 95.5 0.7 4.9e-27 94.1 0.1 2.1 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain DUF3245 PF11595.8 EEA20323.1 - 0.3 11.6 6.1 8.5 6.8 1.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3245) MFS_1 PF07690.16 EEA20324.1 - 1.7e-41 142.4 25.8 2.5e-41 141.8 25.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20324.1 - 8.7e-11 41.3 12.1 8.7e-11 41.3 12.1 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 EEA20324.1 - 0.017 14.0 4.3 0.088 11.7 3.4 2.4 1 1 1 2 2 2 0 MFS_1 like family DUF1751 PF08551.10 EEA20325.1 - 0.0011 19.5 0.5 0.0011 19.5 0.5 1.7 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Glyco_hydro_127 PF07944.12 EEA20326.1 - 3.8e-15 55.4 0.0 4.7e-15 55.1 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_127 PF07944.12 EEA20327.1 - 2.3e-32 112.2 0.0 2.6e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 ADH_zinc_N_2 PF13602.6 EEA20328.1 - 0.00023 22.2 0.0 0.0004 21.4 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA20328.1 - 0.0056 16.6 0.0 0.0089 15.9 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Aldo_ket_red PF00248.21 EEA20329.1 - 6.3e-50 170.0 0.0 1.8e-49 168.6 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family Hydrolase_6 PF13344.6 EEA20330.1 - 1.1e-20 73.6 0.0 2.1e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA20330.1 - 8.9e-20 70.5 0.0 2.1e-19 69.4 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 EEA20330.1 - 0.0015 18.7 0.0 0.062 13.4 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA20330.1 - 0.0097 16.2 0.0 4.6 7.5 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase 5-nucleotidase PF06189.12 EEA20330.1 - 0.026 13.4 0.1 0.042 12.8 0.1 1.2 1 0 0 1 1 1 0 5'-nucleotidase SUZ PF12752.7 EEA20333.1 - 0.00017 22.3 10.1 0.00017 22.3 10.1 4.8 4 2 0 4 4 4 1 SUZ domain eIF3_subunit PF08597.10 EEA20333.1 - 0.3 11.0 10.5 4.5 7.1 5.7 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit GST_N_3 PF13417.6 EEA20334.1 - 4e-21 75.2 0.0 7e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA20334.1 - 2.9e-17 62.7 0.0 5.1e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA20334.1 - 1.1e-10 41.7 0.0 1.7e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA20334.1 - 4.6e-06 26.6 0.0 9.3e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EEA20334.1 - 0.00013 22.5 0.0 0.00022 21.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA20334.1 - 0.0041 17.3 0.0 0.008 16.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EEA20334.1 - 0.013 15.7 0.0 0.033 14.4 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin Hexapep_2 PF14602.6 EEA20336.1 - 1e-12 47.6 5.4 5e-10 39.0 1.9 2.4 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 EEA20336.1 - 1.3e-11 43.8 8.9 2.5e-09 36.5 2.4 2.6 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 EEA20336.1 - 1.4e-10 41.3 0.0 2.2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase DUF525 PF04379.14 EEA20336.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 ApaG domain ATP_bind_1 PF03029.17 EEA20337.1 - 5.5e-72 242.4 0.0 7.3e-72 242.0 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EEA20337.1 - 2.1e-05 24.1 0.0 0.0023 17.5 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EEA20337.1 - 5.8e-05 22.2 0.0 0.049 12.6 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EEA20337.1 - 0.00051 19.8 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EEA20337.1 - 0.00075 19.6 0.0 0.006 16.6 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EEA20337.1 - 0.0016 17.7 0.0 0.047 12.8 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit NACHT PF05729.12 EEA20337.1 - 0.0022 17.9 0.0 0.013 15.5 0.0 2.1 2 0 0 2 2 2 1 NACHT domain PRK PF00485.18 EEA20337.1 - 0.0037 17.0 0.1 0.016 15.0 0.0 2.0 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 EEA20337.1 - 0.0039 17.5 0.0 0.01 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EEA20337.1 - 0.004 16.7 0.0 0.11 12.1 0.0 2.5 3 0 0 3 3 3 1 Ferrous iron transport protein B SRP54 PF00448.22 EEA20337.1 - 0.0056 16.3 0.0 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EEA20337.1 - 0.0057 17.1 0.0 0.014 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EEA20337.1 - 0.0064 15.7 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Arf PF00025.21 EEA20337.1 - 0.0077 15.7 0.0 4.2 6.8 0.0 3.1 3 0 0 3 3 3 1 ADP-ribosylation factor family AAA_33 PF13671.6 EEA20337.1 - 0.0089 16.2 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 EEA20337.1 - 0.016 15.4 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 EEA20337.1 - 0.016 14.9 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EEA20337.1 - 0.017 14.7 0.1 1.1 8.9 0.0 2.3 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CLP1_P PF16575.5 EEA20337.1 - 0.024 14.4 0.0 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_7 PF12775.7 EEA20337.1 - 0.025 14.1 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 EEA20337.1 - 0.026 13.8 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 EEA20337.1 - 0.026 14.4 0.1 8 6.3 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase PduV-EutP PF10662.9 EEA20337.1 - 0.04 13.7 0.0 0.43 10.3 0.0 2.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation APS_kinase PF01583.20 EEA20337.1 - 0.088 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Pox_A32 PF04665.12 EEA20337.1 - 0.2 11.1 0.0 0.69 9.3 0.0 1.8 2 0 0 2 2 2 0 Poxvirus A32 protein CwfJ_C_2 PF04676.14 EEA20338.1 - 6.6e-30 103.9 0.1 2.4e-29 102.1 0.1 2.1 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 EEA20338.1 - 3e-28 98.1 0.0 8.5e-28 96.7 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 FumaraseC_C PF10415.9 EEA20338.1 - 0.23 11.9 0.5 12 6.4 0.1 2.8 2 0 0 2 2 2 0 Fumarase C C-terminus 2-Hacid_dh_C PF02826.19 EEA20339.1 - 5.8e-58 195.2 0.0 7.8e-58 194.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA20339.1 - 1.4e-14 53.9 0.0 2e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA20339.1 - 4.3e-05 23.7 0.2 7.2e-05 23.0 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EEA20339.1 - 0.0029 17.2 0.1 0.0049 16.4 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Rossmann-like PF10727.9 EEA20339.1 - 0.062 13.2 0.0 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 Rossmann-like domain F420_oxidored PF03807.17 EEA20339.1 - 0.14 12.8 0.0 0.29 11.8 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Zn_clus PF00172.18 EEA20340.1 - 2e-08 34.2 8.6 3.4e-08 33.5 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-U1 PF06220.12 EEA20341.1 - 1.3e-07 31.3 0.4 2.5e-07 30.4 0.4 1.5 1 0 0 1 1 1 1 U1 zinc finger ABC_tran_Xtn PF12848.7 EEA20341.1 - 8.3 6.5 10.2 2 8.5 5.1 2.5 2 1 0 2 2 2 0 ABC transporter CAP_GLY PF01302.25 EEA20342.1 - 3.6e-20 71.7 0.1 7.7e-20 70.7 0.1 1.6 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EEA20342.1 - 1.1e-09 38.4 18.7 0.016 15.6 1.7 5.8 4 1 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA20342.1 - 1.8e-08 34.0 19.1 1.5e-05 24.6 1.5 4.8 3 2 3 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 EEA20342.1 - 7.5e-08 32.1 2.2 0.045 13.2 0.8 3.9 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 EEA20342.1 - 1.7e-06 27.6 6.8 0.76 10.0 0.1 5.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 EEA20342.1 - 0.0027 18.0 3.7 1.3e+02 3.8 0.0 6.7 6 0 0 6 6 6 0 Leucine Rich Repeat DUF1619 PF07773.11 EEA20342.1 - 0.031 14.2 0.1 0.053 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1619) SF3A2 PF16835.5 EEA20343.1 - 1.3e-36 124.9 0.0 1.9e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EEA20343.1 - 1.8e-05 24.9 1.7 2e-05 24.8 0.5 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type PRP4 PF08799.11 EEA20343.1 - 0.048 13.2 1.5 0.11 12.1 1.5 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Pkinase PF00069.25 EEA20344.1 - 9.9e-55 185.7 0.0 1.7e-53 181.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20344.1 - 8e-25 87.6 0.5 1.8e-19 70.0 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA20344.1 - 4.9e-06 25.7 0.0 7.1e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EEA20344.1 - 4.6e-05 23.5 3.2 0.021 14.8 0.1 3.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA20344.1 - 0.00028 20.3 0.0 0.00066 19.1 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA20344.1 - 0.0016 17.8 0.4 0.0037 16.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EEA20344.1 - 0.0071 15.4 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EEA20344.1 - 0.033 13.0 0.0 0.058 12.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EEA20344.1 - 0.037 13.6 0.2 7.7 6.1 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Zn_clus PF00172.18 EEA20345.1 - 1.2e-06 28.6 12.3 2.2e-06 27.7 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA20345.1 - 3e-06 26.3 0.9 4.3e-06 25.8 0.9 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain RRM PF10378.9 EEA20345.1 - 0.084 12.6 0.1 1.2 8.9 0.0 2.5 2 0 0 2 2 2 0 Putative RRM domain Tim54 PF11711.8 EEA20346.1 - 4.5e-151 502.9 0.6 5.3e-151 502.6 0.6 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 NARP1 PF12569.8 EEA20347.1 - 3.5e-222 738.9 23.1 2.9e-219 729.3 18.6 2.3 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 EEA20347.1 - 2.6e-20 72.7 31.4 0.00078 19.9 0.3 7.3 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 EEA20347.1 - 3.1e-17 61.8 22.6 0.12 13.2 0.2 11.1 8 4 4 12 12 10 5 Tetratricopeptide repeat TPR_2 PF07719.17 EEA20347.1 - 6.2e-17 60.3 41.6 0.0012 18.8 0.2 11.5 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 EEA20347.1 - 7.5e-13 48.9 22.7 0.077 13.7 0.6 8.7 7 1 2 10 10 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA20347.1 - 5.2e-12 45.8 14.1 1.2e-05 25.5 0.7 5.2 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EEA20347.1 - 3.4e-09 36.7 10.3 0.034 14.3 1.6 6.4 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA20347.1 - 1.3e-07 31.5 8.3 0.61 10.6 0.0 6.6 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EEA20347.1 - 2.6e-07 30.2 12.3 0.00026 20.6 0.2 6.4 7 1 1 8 8 7 2 TPR repeat TPR_8 PF13181.6 EEA20347.1 - 1.4e-06 28.0 30.6 0.0008 19.4 0.0 8.5 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA20347.1 - 2.2e-06 27.3 36.6 3.9e-05 23.3 0.5 10.0 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA20347.1 - 0.00018 21.7 30.4 1.1 9.5 0.3 8.7 7 2 1 9 9 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA20347.1 - 0.00021 20.8 2.9 2.4 7.4 0.0 3.9 3 1 0 3 3 3 2 MalT-like TPR region TPR_4 PF07721.14 EEA20347.1 - 0.001 19.5 4.7 1.9 9.3 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 EEA20347.1 - 0.012 15.6 3.8 2.2 8.4 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA20347.1 - 0.28 11.9 24.7 2.3 9.0 0.2 8.6 11 0 0 11 11 9 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EEA20347.1 - 0.69 10.0 9.3 0.95 9.6 0.1 4.2 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat Phage_Nu1 PF07471.12 EEA20347.1 - 3.2 7.5 7.1 3.4 7.4 2.0 2.5 2 0 0 2 2 2 0 Phage DNA packaging protein Nu1 DUF2229 PF09989.9 EEA20347.1 - 6.7 6.3 7.3 0.8 9.3 0.2 2.9 4 0 0 4 4 4 0 CoA enzyme activase uncharacterised domain (DUF2229) Cid2 PF09774.9 EEA20348.1 - 3.2e-54 183.7 2.8 4.3e-54 183.2 2.8 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 SpoVR PF04293.13 EEA20348.1 - 0.035 12.8 0.0 0.048 12.3 0.0 1.1 1 0 0 1 1 1 0 SpoVR like protein AIM5 PF17050.5 EEA20348.1 - 0.68 10.8 3.9 23 5.9 0.1 3.0 2 1 1 3 3 3 0 Altered inheritance of mitochondria 5 Fapy_DNA_glyco PF01149.24 EEA20349.1 - 7.3e-36 123.3 0.0 1.7e-35 122.1 0.0 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EEA20349.1 - 9.1e-22 76.9 0.0 1.9e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.11 EEA20349.1 - 0.0024 16.7 0.0 0.0059 15.4 0.0 1.6 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_S13 PF00416.22 EEA20349.1 - 0.038 14.4 0.5 0.091 13.2 0.0 1.9 3 0 0 3 3 3 0 Ribosomal protein S13/S18 Fe_hyd_lg_C PF02906.14 EEA20350.1 - 6.4e-53 179.9 0.0 1.3e-52 178.9 0.0 1.5 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain DNA_RNApol_7kD PF03604.13 EEA20351.1 - 9.7e-17 60.3 1.0 1.3e-16 60.0 1.0 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_4 PF13717.6 EEA20351.1 - 0.0024 17.8 1.5 0.011 15.6 1.5 2.0 1 1 0 1 1 1 1 zinc-ribbon domain zf_UBZ PF18439.1 EEA20351.1 - 0.0047 16.5 0.8 1.9 8.1 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger DZR PF12773.7 EEA20351.1 - 0.013 15.5 0.8 0.018 15.0 0.8 1.2 1 0 0 1 1 1 0 Double zinc ribbon TackOD1 PF18551.1 EEA20351.1 - 0.028 14.1 0.2 0.032 13.9 0.2 1.1 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 ADK_lid PF05191.14 EEA20351.1 - 0.035 14.1 1.1 0.051 13.6 1.1 1.3 1 0 0 1 1 1 0 Adenylate kinase, active site lid Zn_ribbon_recom PF13408.6 EEA20351.1 - 0.035 14.6 0.8 2.6 8.6 0.1 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain HypA PF01155.19 EEA20351.1 - 0.044 13.8 0.4 0.053 13.5 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Nudix_N_2 PF14803.6 EEA20351.1 - 0.054 13.4 1.3 8.8 6.3 0.1 2.7 3 0 0 3 3 3 0 Nudix N-terminal TFIIS_C PF01096.18 EEA20351.1 - 0.054 13.4 0.4 2.6 8.0 0.0 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-C2H2_11 PF16622.5 EEA20351.1 - 0.099 12.4 1.9 1.2 8.9 0.3 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type Tnp_zf-ribbon_2 PF13842.6 EEA20351.1 - 0.22 12.4 2.6 2.3 9.1 0.1 2.2 1 1 1 2 2 2 0 DDE_Tnp_1-like zinc-ribbon C1_4 PF07975.12 EEA20351.1 - 0.24 11.7 2.0 0.3 11.3 0.1 1.9 1 1 1 2 2 2 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 EEA20351.1 - 0.72 10.0 4.4 6.8 6.9 0.5 2.1 1 1 1 2 2 2 0 Zinc ribbon domain Glycos_transf_3 PF00591.21 EEA20352.1 - 9.6e-56 189.2 0.0 4.7e-53 180.4 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EEA20352.1 - 3.2e-06 26.9 0.5 6.4e-06 25.9 0.5 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain VAD1-2 PF15310.6 EEA20353.1 - 0.00022 21.2 0.5 0.0004 20.4 0.5 1.3 1 0 0 1 1 1 1 Vitamin A-deficiency (VAD) rat model signalling Ribosomal_L10 PF00466.20 EEA20353.1 - 0.00058 20.0 0.1 0.019 15.1 0.1 2.7 1 1 0 1 1 1 1 Ribosomal protein L10 P22_Tail-4 PF11650.8 EEA20353.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 P22 tail accessory factor PI-PLC-X PF00388.19 EEA20354.1 - 3.6e-11 42.8 0.0 5.8e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain 2-oxoacid_dh PF00198.23 EEA20355.1 - 2.3e-78 262.8 0.5 3.7e-78 262.2 0.5 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EEA20355.1 - 3.7e-14 52.3 0.0 9.2e-14 51.0 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EEA20355.1 - 1.5e-11 44.4 0.9 3e-11 43.5 0.1 2.0 2 0 0 2 2 2 1 e3 binding domain BNIP2 PF12496.8 EEA20355.1 - 1 9.8 4.3 0.25 11.8 0.5 1.9 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 AAA_18 PF13238.6 EEA20356.1 - 3.8e-10 40.4 0.0 1.1e-09 38.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA20356.1 - 1.7e-09 38.0 0.0 5e-09 36.5 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 EEA20356.1 - 5.1e-06 27.0 0.0 7.6e-05 23.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 EEA20356.1 - 5.4e-06 26.6 0.0 2.2e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 Shikimate kinase Cytidylate_kin PF02224.18 EEA20356.1 - 0.00025 20.8 0.0 0.00054 19.8 0.0 1.5 1 0 0 1 1 1 1 Cytidylate kinase dNK PF01712.19 EEA20356.1 - 0.00068 19.5 0.0 0.21 11.4 0.0 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA_22 PF13401.6 EEA20356.1 - 0.001 19.3 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EEA20356.1 - 0.0015 18.9 0.0 0.0027 18.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EEA20356.1 - 0.0096 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EEA20356.1 - 0.011 15.1 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 EEA20356.1 - 0.011 16.1 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 EEA20356.1 - 0.014 15.7 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EEA20356.1 - 0.018 15.0 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain DUF2075 PF09848.9 EEA20356.1 - 0.022 14.0 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EEA20356.1 - 0.024 13.7 0.0 0.04 13.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 EEA20356.1 - 0.026 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ADK PF00406.22 EEA20356.1 - 0.028 14.5 0.0 1.8 8.7 0.0 2.1 2 0 0 2 2 2 0 Adenylate kinase AAA_24 PF13479.6 EEA20356.1 - 0.032 14.0 0.0 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EEA20356.1 - 0.038 14.4 0.0 0.092 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase RuvB_N PF05496.12 EEA20356.1 - 0.044 13.5 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EEA20356.1 - 0.052 12.9 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CoaE PF01121.20 EEA20356.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase Thermopsin PF05317.11 EEA20356.1 - 0.076 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Thermopsin cobW PF02492.19 EEA20356.1 - 0.084 12.5 0.0 0.33 10.5 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EEA20356.1 - 0.084 13.4 0.0 0.18 12.3 0.0 1.6 2 0 0 2 2 1 0 ABC transporter APS_kinase PF01583.20 EEA20356.1 - 0.091 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_29 PF13555.6 EEA20356.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 EEA20356.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EEA20356.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA20356.1 - 0.13 12.2 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 NTPase PRK PF00485.18 EEA20356.1 - 0.13 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EEA20356.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.16 EEA20356.1 - 0.19 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Vps26 PF03643.15 EEA20357.1 - 5.4e-130 432.3 0.2 6.5e-130 432.1 0.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EEA20357.1 - 0.00016 21.7 0.1 0.82 9.7 0.0 3.1 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain DCB PF16213.5 EEA20358.1 - 1.7e-40 138.6 4.9 1.7e-40 138.6 4.9 3.1 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EEA20358.1 - 2e-38 131.8 16.2 1.6e-37 128.8 4.3 4.2 4 1 0 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 EEA20358.1 - 3.7e-22 78.3 5.2 6.3e-22 77.6 0.8 3.1 3 0 0 3 3 3 1 C-terminal region of Mon2 protein DUF1981 PF09324.10 EEA20358.1 - 7.5e-05 22.5 0.1 0.35 10.8 0.0 5.5 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) Ipi1_N PF12333.8 EEA20358.1 - 0.00055 20.5 2.4 1.9 9.1 0.1 5.0 4 0 0 4 4 4 1 Rix1 complex component involved in 60S ribosome maturation UQ_con PF00179.26 EEA20359.1 - 5.2e-20 71.5 0.0 5.4e-20 71.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA20359.1 - 0.015 15.6 0.0 0.015 15.6 0.0 1.2 1 0 0 1 1 1 0 RWD domain Complex1_LYR PF05347.15 EEA20360.1 - 2.2e-13 50.0 0.0 5.4e-13 48.8 0.0 1.7 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EEA20360.1 - 0.018 15.8 0.0 0.05 14.4 0.0 1.8 1 1 0 1 1 1 0 Complex1_LYR-like RWD PF05773.22 EEA20361.1 - 8.9e-25 87.2 2.3 8.9e-25 87.2 2.3 1.7 2 0 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EEA20361.1 - 0.1 13.1 18.8 0.3 11.6 18.1 2.2 1 1 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 Zip PF02535.22 EEA20361.1 - 0.23 10.6 1.4 0.27 10.4 1.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_S15 PF02129.18 EEA20361.1 - 1.1 8.8 4.1 0.65 9.5 1.3 1.8 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Presenilin PF01080.17 EEA20361.1 - 2.4 6.8 5.5 3 6.5 5.5 1.1 1 0 0 1 1 1 0 Presenilin DRY_EERY PF09750.9 EEA20361.1 - 3.1 8.1 11.0 7 6.9 11.0 1.6 1 0 0 1 1 1 0 Alternative splicing regulator TPR_12 PF13424.6 EEA20362.1 - 1.8e-12 47.4 0.9 3.8e-07 30.3 0.2 3.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA20362.1 - 1.2e-11 44.9 4.1 3.8e-06 27.3 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA20362.1 - 1.6e-07 31.0 2.6 0.00072 19.6 0.0 4.6 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA20362.1 - 3.5e-07 29.8 3.2 0.007 16.4 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA20362.1 - 1.3e-06 28.1 1.6 0.00082 18.8 0.0 2.7 2 1 0 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 EEA20362.1 - 4.7e-06 27.1 1.5 0.087 13.5 0.3 4.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EEA20362.1 - 1.7e-05 25.3 4.9 1.4 9.9 0.1 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA20362.1 - 6.7e-05 22.5 0.1 0.12 12.2 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EEA20362.1 - 7.1e-05 22.9 7.9 0.012 15.7 0.2 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA20362.1 - 0.00051 20.2 0.3 0.98 9.7 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EEA20362.1 - 0.0017 18.0 0.2 0.012 15.3 0.0 2.6 3 0 0 3 3 3 1 TPR repeat TPR_10 PF13374.6 EEA20362.1 - 0.0026 17.6 0.9 9.7 6.2 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA20362.1 - 0.0081 16.5 0.3 1.1e+02 3.5 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Cas_Cas02710 PF09670.10 EEA20362.1 - 0.017 13.9 0.3 0.051 12.4 0.1 1.7 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas02710) TPR_7 PF13176.6 EEA20362.1 - 0.018 15.0 0.2 8.8 6.6 0.0 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EEA20362.1 - 0.021 14.3 4.3 0.41 10.1 0.1 3.3 3 0 0 3 3 3 0 SHNi-TPR TPR_6 PF13174.6 EEA20362.1 - 0.24 12.1 4.6 1.3e+02 3.6 0.1 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EEA20362.1 - 6.7 7.7 8.2 17 6.4 0.6 3.5 4 0 0 4 4 2 0 Tetratricopeptide repeat SIR2 PF02146.17 EEA20363.1 - 2.9e-59 200.0 0.0 4e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EEA20363.1 - 0.0011 18.7 0.1 0.0035 17.1 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EEA20363.1 - 0.0029 17.4 0.1 1 9.1 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain NUMOD1 PF07453.13 EEA20363.1 - 0.14 12.5 0.1 0.32 11.3 0.1 1.6 1 0 0 1 1 1 0 NUMOD1 domain UPF0020 PF01170.18 EEA20364.1 - 2.3e-10 40.5 0.0 9.1e-06 25.5 0.0 2.6 2 1 0 3 3 3 2 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EEA20364.1 - 0.00014 21.7 0.1 0.00052 19.8 0.0 1.9 2 0 0 2 2 2 1 DNA methylase N6_Mtase PF02384.16 EEA20364.1 - 0.00039 19.8 0.0 0.00061 19.2 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase HIT PF01230.23 EEA20365.1 - 1.3e-16 61.1 0.1 6e-16 59.0 0.1 1.9 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 EEA20365.1 - 0.0019 18.7 0.0 0.0032 17.9 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EEA20365.1 - 0.005 16.7 0.2 0.028 14.3 0.2 2.1 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Cyclin_N PF00134.23 EEA20366.1 - 1e-46 157.8 0.1 6.7e-45 151.9 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA20366.1 - 4e-35 120.5 0.2 7.7e-35 119.6 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 EEA20367.1 - 1e-46 157.8 0.1 6.6e-45 151.9 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA20367.1 - 3.9e-35 120.5 0.2 7.6e-35 119.6 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_L2_C PF03947.18 EEA20368.1 - 2.6e-52 176.3 2.8 4.2e-51 172.4 2.1 2.6 2 1 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EEA20368.1 - 1.8e-27 95.1 1.2 4.2e-27 93.9 1.2 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain NusG_II PF07009.11 EEA20368.1 - 0.19 11.9 0.3 0.34 11.1 0.3 1.3 1 0 0 1 1 1 0 NusG domain II Fungal_trans PF04082.18 EEA20369.1 - 4.7e-14 52.1 0.0 1.2e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20369.1 - 2.8e-10 40.2 9.8 5e-10 39.3 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4691 PF15762.5 EEA20369.1 - 0.0064 16.7 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4691) WD40 PF00400.32 EEA20370.1 - 1.5e-26 92.1 7.2 1.2e-05 26.0 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20370.1 - 1.6e-19 70.0 0.0 0.00041 20.6 0.0 5.8 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EEA20370.1 - 2.9e-08 32.6 0.0 0.00047 18.8 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 EEA20370.1 - 2.8e-05 24.1 0.0 0.3 11.0 0.1 3.0 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 EEA20370.1 - 0.0014 17.8 0.0 0.052 12.6 0.0 2.4 2 1 0 2 2 2 1 Coatomer WD associated region Nup160 PF11715.8 EEA20370.1 - 0.011 14.5 0.4 0.2 10.3 0.1 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EEA20370.1 - 0.11 11.4 0.0 0.24 10.3 0.0 1.5 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 EEA20370.1 - 0.17 10.8 0.1 6.5 5.6 0.0 3.0 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribonuc_P_40 PF08584.11 EEA20371.1 - 7e-67 225.7 0.0 2.7e-66 223.8 0.0 1.7 2 0 0 2 2 2 1 Ribonuclease P 40kDa (Rpp40) subunit Dna2 PF08696.11 EEA20373.1 - 1.7e-68 230.4 0.8 4.1e-68 229.2 0.8 1.7 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EEA20373.1 - 9.9e-56 188.5 0.0 2.3e-55 187.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EEA20373.1 - 6.9e-32 111.2 2.3 7.5e-16 58.7 0.0 2.9 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 EEA20373.1 - 2.1e-14 53.7 0.0 4.4e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA20373.1 - 1.6e-12 48.0 0.2 5.5e-12 46.2 0.1 2.0 2 0 0 2 2 1 1 AAA domain Cas_Cas4 PF01930.17 EEA20373.1 - 8.5e-10 39.0 0.5 4.1e-08 33.5 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 EEA20373.1 - 8.2e-08 32.5 0.1 1.6e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.18 EEA20373.1 - 1.5e-05 24.8 3.2 0.25 11.1 0.1 3.7 3 1 1 4 4 3 1 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 EEA20373.1 - 7.6e-05 22.6 0.0 0.00018 21.4 0.0 1.7 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 EEA20373.1 - 0.00083 19.0 0.2 0.00083 19.0 0.2 2.8 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.22 EEA20373.1 - 0.0011 18.6 0.1 0.0022 17.7 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain PIF1 PF05970.14 EEA20373.1 - 0.0028 16.9 0.3 0.018 14.2 0.3 2.1 1 1 0 1 1 1 1 PIF1-like helicase ResIII PF04851.15 EEA20373.1 - 0.0037 17.3 2.1 0.0089 16.1 0.1 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 EEA20373.1 - 0.0049 17.3 0.0 0.014 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 EEA20373.1 - 0.0064 16.6 0.1 0.031 14.3 0.1 2.2 2 0 0 2 2 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 EEA20373.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EEA20373.1 - 0.026 14.6 0.3 0.11 12.6 0.3 2.0 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_7 PF12775.7 EEA20373.1 - 0.032 13.8 0.1 0.075 12.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EEA20373.1 - 0.033 13.7 0.0 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EEA20373.1 - 0.041 13.8 0.1 0.096 12.6 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 EEA20373.1 - 0.054 14.0 0.0 0.22 12.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EEA20373.1 - 0.059 12.6 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EEA20373.1 - 0.066 13.1 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 NTPase AAA_22 PF13401.6 EEA20373.1 - 0.093 13.0 0.3 1.6 9.0 0.0 3.1 2 1 1 3 3 2 0 AAA domain RuvB_N PF05496.12 EEA20373.1 - 0.12 12.1 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EEA20373.1 - 0.13 12.2 0.0 0.41 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EEA20373.1 - 0.14 12.5 0.0 0.42 11.0 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 EEA20373.1 - 0.17 11.8 0.1 0.6 10.0 0.0 2.0 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain IstB_IS21 PF01695.17 EEA20373.1 - 0.17 11.6 0.4 0.79 9.4 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein MeaB PF03308.16 EEA20373.1 - 0.17 10.8 0.0 0.35 9.8 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ESSS PF10183.9 EEA20374.1 - 4.3e-21 75.1 0.0 5.4e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) CN_hydrolase PF00795.22 EEA20375.1 - 9.3e-58 195.6 0.1 1e-57 195.4 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Clathrin_propel PF01394.20 EEA20375.1 - 0.84 10.1 2.3 27 5.3 0.0 2.8 3 0 0 3 3 3 0 Clathrin propeller repeat RNB PF00773.19 EEA20376.1 - 4.6e-98 328.6 0.0 6.9e-98 328.0 0.0 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EEA20376.1 - 6.5e-33 113.5 0.2 2e-32 111.9 0.2 1.9 1 1 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EEA20376.1 - 7.5e-28 96.3 0.3 2.3e-27 94.8 0.3 1.9 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 EEA20376.1 - 6.1e-21 74.2 0.0 2.9e-20 72.1 0.0 2.2 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EEA20376.1 - 1.8e-11 44.5 0.1 4.3e-11 43.2 0.1 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 EEA20376.1 - 1.7e-09 37.7 0.0 1.3e-05 25.2 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain LIM PF00412.22 EEA20377.1 - 3e-27 94.6 21.2 2.4e-10 40.5 4.8 3.7 3 1 0 3 3 3 3 LIM domain Ribosomal_60s PF00428.19 EEA20377.1 - 0.017 15.7 3.8 0.044 14.4 3.8 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Zn_ribbon_recom PF13408.6 EEA20377.1 - 0.2 12.2 0.1 0.2 12.2 0.1 2.7 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Methyltransf_4 PF02390.17 EEA20378.1 - 1e-42 145.5 1.0 6.4e-28 97.4 0.0 3.2 2 1 1 3 3 3 3 Putative methyltransferase DUF913 PF06025.12 EEA20378.1 - 0.00083 18.4 0.1 0.066 12.2 0.0 2.1 2 0 0 2 2 2 2 Domain of Unknown Function (DUF913) Methyltransf_25 PF13649.6 EEA20378.1 - 0.0054 17.4 0.0 0.037 14.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EEA20378.1 - 0.01 15.8 0.0 0.029 14.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EEA20378.1 - 0.016 14.8 0.0 0.18 11.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EEA20378.1 - 0.026 15.3 0.1 0.17 12.6 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_31 PF13847.6 EEA20378.1 - 0.083 12.7 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_60s PF00428.19 EEA20378.1 - 0.3 11.7 10.9 0.7 10.5 7.2 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3391 PF11871.8 EEA20378.1 - 0.67 10.5 5.5 6.4 7.3 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Cytomega_UL84 PF06284.11 EEA20378.1 - 9.9 4.5 7.8 14 3.9 7.8 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein ESCRT-II PF05871.12 EEA20379.1 - 6.2e-49 165.9 0.6 8.3e-49 165.4 0.6 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit PTCB-BRCT PF12738.7 EEA20380.1 - 3.4e-37 126.2 0.6 1.1e-20 73.4 0.2 6.4 6 1 0 6 6 6 4 twin BRCT domain RTT107_BRCT_5 PF16770.5 EEA20380.1 - 1.5e-35 121.0 0.0 1.3e-31 108.4 0.0 3.9 4 0 0 4 4 4 2 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EEA20380.1 - 4.1e-32 110.4 0.0 2.4e-09 37.4 0.0 6.9 6 1 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EEA20380.1 - 3.6e-25 88.2 0.0 4e-06 27.1 0.0 6.5 6 0 0 6 6 6 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EEA20380.1 - 8.2e-12 45.2 0.0 0.00033 20.9 0.0 4.5 4 0 0 4 4 4 3 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EEA20380.1 - 0.01 15.9 0.0 4.4 7.4 0.0 3.2 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain Mcm10 PF09332.11 EEA20380.1 - 8.5 5.7 10.9 13 5.1 10.9 1.2 1 0 0 1 1 1 0 Mcm10 replication factor GMC_oxred_N PF00732.19 EEA20382.1 - 1.3e-64 218.5 0.0 1.6e-64 218.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA20382.1 - 8.9e-31 107.3 0.0 1.7e-30 106.4 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EEA20382.1 - 1.5e-06 27.6 0.3 0.0085 15.2 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA20382.1 - 0.00014 22.0 0.2 0.00037 20.6 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EEA20382.1 - 0.00031 20.1 0.0 0.56 9.4 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA20382.1 - 0.0017 17.6 0.3 0.0069 15.7 0.0 1.8 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EEA20382.1 - 0.0023 17.6 0.2 0.01 15.4 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EEA20382.1 - 0.0058 15.7 0.1 0.0092 15.1 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EEA20382.1 - 0.06 12.6 0.1 1 8.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA20382.1 - 0.073 11.8 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Abhydrolase_6 PF12697.7 EEA20384.1 - 4.7e-13 50.2 0.2 7.3e-13 49.6 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA20384.1 - 3.9e-06 26.3 0.0 6.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA20384.1 - 0.00037 20.2 0.0 0.0013 18.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold PTH2 PF01981.16 EEA20384.1 - 0.029 14.7 0.7 0.061 13.6 0.7 1.4 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 Ceramidase PF05875.12 EEA20385.1 - 1.3e-105 352.5 9.7 1.6e-105 352.3 9.7 1.0 1 0 0 1 1 1 1 Ceramidase Peptidase_U4 PF03419.13 EEA20385.1 - 0.14 11.5 7.5 0.72 9.1 0.5 2.1 2 0 0 2 2 2 0 Sporulation factor SpoIIGA DUF4131 PF13567.6 EEA20385.1 - 0.17 11.5 4.2 1.2 8.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Spc7 PF08317.11 EEA20386.1 - 0.0033 16.4 10.7 0.0033 16.4 10.7 5.1 5 1 0 5 5 5 2 Spc7 kinetochore protein Sigma70_r1_1 PF03979.14 EEA20386.1 - 1.2 9.2 6.6 0.35 11.0 1.2 2.7 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 ATG16 PF08614.11 EEA20386.1 - 5.2 7.2 0.0 5.2 7.2 0.0 5.6 4 1 0 5 5 5 0 Autophagy protein 16 (ATG16) Fungal_trans_2 PF11951.8 EEA20387.1 - 8.3e-61 205.9 0.6 1.1e-60 205.5 0.6 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain HDA2-3 PF11496.8 EEA20387.1 - 0.16 11.1 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 V-ATPase_H_N PF03224.14 EEA20388.1 - 7.6e-78 262.0 0.0 1e-77 261.6 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EEA20388.1 - 8.5e-37 125.8 0.0 3.8e-36 123.7 0.0 2.2 2 0 0 2 2 2 1 V-ATPase subunit H TMF_TATA_bd PF12325.8 EEA20390.1 - 1.8e-41 140.9 12.9 1.8e-41 140.9 12.9 6.9 3 1 4 7 7 4 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EEA20390.1 - 5.4e-21 74.4 15.5 5.4e-21 74.4 15.5 9.6 6 2 4 10 10 9 2 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 EEA20390.1 - 1.2e-05 25.6 5.5 1.2e-05 25.6 5.5 5.3 2 1 1 3 3 2 1 Autophagy protein 16 (ATG16) BST2 PF16716.5 EEA20390.1 - 0.00057 20.4 11.1 0.00057 20.4 11.1 7.3 4 2 3 7 7 7 2 Bone marrow stromal antigen 2 Spc7 PF08317.11 EEA20390.1 - 0.0012 17.8 18.6 0.0012 17.8 18.6 5.4 2 1 1 4 4 4 2 Spc7 kinetochore protein Golgin_A5 PF09787.9 EEA20390.1 - 0.0049 16.4 86.0 0.2 11.1 32.8 4.4 3 1 1 4 4 4 4 Golgin subfamily A member 5 AAA_13 PF13166.6 EEA20390.1 - 0.18 10.4 70.6 0.79 8.3 11.4 4.1 2 1 2 4 4 4 0 AAA domain MCR_C PF04609.12 EEA20390.1 - 1.4 7.9 5.1 0.3 10.1 0.4 2.2 2 1 1 3 3 3 0 Methyl-coenzyme M reductase operon protein C DASH_Duo1 PF08651.10 EEA20390.1 - 3.1 7.6 11.7 0.038 13.8 1.3 3.4 4 0 0 4 4 4 0 DASH complex subunit Duo1 DUF3584 PF12128.8 EEA20390.1 - 3.1 5.2 94.1 0.2 9.2 8.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 EEA20390.1 - 4.7 6.5 77.4 0.043 13.2 5.2 4.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) GAS PF13851.6 EEA20390.1 - 7 5.9 95.3 0.94 8.8 15.9 5.2 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding Ank_2 PF12796.7 EEA20391.1 - 2.5e-37 127.3 4.5 5.1e-15 55.8 0.4 3.5 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA20391.1 - 5.8e-36 122.4 3.8 1.4e-08 35.0 0.1 5.6 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA20391.1 - 1.4e-34 117.6 1.7 1.9e-09 37.6 0.1 4.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA20391.1 - 3.3e-29 97.7 1.7 9e-05 22.6 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EEA20391.1 - 5.1e-23 80.5 4.1 8e-05 22.9 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_2 PF12796.7 EEA20392.1 - 2.1e-39 134.0 3.9 6.2e-15 55.6 0.4 3.7 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA20392.1 - 4.3e-32 109.8 1.7 2.2e-09 37.4 0.1 5.6 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA20392.1 - 1.6e-31 108.3 4.2 1.5e-08 35.0 0.0 5.8 1 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA20392.1 - 6.1e-29 96.9 1.7 0.0001 22.4 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EEA20392.1 - 1.8e-22 78.7 4.2 8.9e-05 22.8 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat WD40 PF00400.32 EEA20393.1 - 2.4e-44 148.4 12.9 5.8e-09 36.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20393.1 - 1.9e-06 28.1 0.8 3.2 8.1 0.0 5.3 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA20393.1 - 0.0065 15.8 0.0 0.014 14.8 0.0 1.6 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 EEA20393.1 - 0.079 11.6 1.7 39 2.7 0.0 4.1 1 1 4 5 5 5 0 Nucleoporin Nup120/160 Oxidored_FMN PF00724.20 EEA20394.1 - 2.5e-43 148.7 0.0 3.3e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EEA20394.1 - 0.0032 16.6 0.3 0.0064 15.6 0.0 1.6 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) AAA PF00004.29 EEA20395.1 - 3.6e-15 56.6 0.0 6.9e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EEA20395.1 - 5.1e-13 49.0 1.6 6.3e-12 45.5 0.7 2.5 1 1 1 2 2 2 1 AAA lid domain AAA_16 PF13191.6 EEA20395.1 - 2.2e-10 41.2 0.0 1.8e-09 38.2 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA20395.1 - 1.6e-08 34.9 0.0 4.6e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain BAH PF01426.18 EEA20395.1 - 4.8e-06 26.4 0.0 1.5e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 BAH domain AAA_19 PF13245.6 EEA20395.1 - 0.0019 18.5 0.0 0.0042 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EEA20395.1 - 0.0042 16.9 0.2 0.011 15.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EEA20395.1 - 0.0089 16.3 0.0 0.023 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EEA20395.1 - 0.02 14.8 0.0 0.064 13.2 0.0 1.9 1 1 0 1 1 1 0 NACHT domain PIF1 PF05970.14 EEA20395.1 - 0.046 12.9 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase RNA_helicase PF00910.22 EEA20395.1 - 0.05 14.0 0.0 0.25 11.8 0.0 2.2 2 0 0 2 2 1 0 RNA helicase AAA_18 PF13238.6 EEA20395.1 - 0.052 14.1 0.0 0.16 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA20395.1 - 0.087 12.7 0.0 1.8 8.4 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EEA20395.1 - 0.1 12.7 0.0 0.53 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EEA20395.1 - 0.13 11.5 0.0 0.33 10.1 0.0 1.6 2 0 0 2 2 2 0 KAP family P-loop domain TsaE PF02367.17 EEA20395.1 - 0.15 12.0 0.0 0.41 10.7 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MEDS PF14417.6 EEA20395.1 - 0.18 11.6 0.0 19 5.1 0.0 3.1 3 0 0 3 3 3 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Prefoldin PF02996.17 EEA20397.1 - 8.4e-26 90.2 1.1 1e-25 89.9 1.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EEA20397.1 - 0.00056 19.8 2.6 0.011 15.7 0.7 2.1 2 0 0 2 2 2 1 Prefoldin subunit UvsW PF11637.8 EEA20397.1 - 0.0022 18.1 0.5 0.0093 16.0 0.5 2.1 2 1 0 2 2 2 1 ATP-dependant DNA helicase UvsW Fib_alpha PF08702.10 EEA20397.1 - 0.0049 17.1 3.4 1 9.6 0.8 2.1 1 1 1 2 2 2 2 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EEA20397.1 - 0.011 16.0 0.4 0.18 12.2 0.1 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Dynamitin PF04912.14 EEA20397.1 - 0.018 14.4 0.3 0.022 14.1 0.3 1.1 1 0 0 1 1 1 0 Dynamitin PHM7_cyt PF14703.6 EEA20397.1 - 0.024 14.9 1.1 0.056 13.7 1.1 1.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Tektin PF03148.14 EEA20397.1 - 0.033 12.9 1.3 2 7.1 0.2 2.0 2 0 0 2 2 2 0 Tektin family Erf4 PF10256.9 EEA20397.1 - 0.046 13.8 0.1 2 8.6 0.1 2.4 1 1 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Snapin_Pallidin PF14712.6 EEA20397.1 - 0.065 13.7 1.4 3.2 8.2 0.1 2.2 2 0 0 2 2 2 0 Snapin/Pallidin Serine_rich PF08824.10 EEA20397.1 - 0.083 12.9 0.1 0.68 9.9 0.1 1.9 2 0 0 2 2 2 0 Serine rich protein interaction domain DUF4164 PF13747.6 EEA20397.1 - 0.1 12.9 0.9 14 6.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) CLZ PF16526.5 EEA20397.1 - 0.12 12.7 2.9 1 9.8 0.4 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Med30 PF11315.8 EEA20397.1 - 0.12 12.5 1.0 5.5 7.2 0.3 2.1 2 0 0 2 2 2 0 Mediator complex subunit 30 DUF4315 PF14193.6 EEA20397.1 - 0.19 11.8 3.6 0.2 11.7 0.8 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4315) BST2 PF16716.5 EEA20397.1 - 0.2 12.3 3.0 6.4 7.4 0.2 2.6 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 YvrJ PF12841.7 EEA20397.1 - 0.36 10.4 1.7 9.9 5.8 0.1 2.3 2 0 0 2 2 2 0 YvrJ protein family TMF_DNA_bd PF12329.8 EEA20397.1 - 0.48 10.5 5.0 4 7.5 1.8 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding tRNA-synt_2b PF00587.25 EEA20398.1 - 4.6e-31 108.2 0.0 1.2e-30 106.8 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EEA20398.1 - 1.4e-10 41.2 0.0 3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain zf-H2C2_2 PF13465.6 EEA20398.1 - 0.18 12.3 0.9 7.2 7.2 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain CBF PF03914.17 EEA20399.1 - 8.5e-57 191.9 0.6 8.5e-57 191.9 0.6 3.4 4 1 0 4 4 4 1 CBF/Mak21 family Peroxin-13_N PF04088.13 EEA20399.1 - 0.41 10.9 6.1 14 5.9 0.0 4.1 3 0 0 3 3 3 0 Peroxin 13, N-terminal region Aa_trans PF01490.18 EEA20400.1 - 3.5e-25 88.6 34.6 4.2e-25 88.3 34.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein GCV_T PF01571.21 EEA20401.1 - 1e-75 254.5 0.0 1.3e-75 254.2 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EEA20401.1 - 1.9e-14 53.4 0.0 3.8e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain MFS_1 PF07690.16 EEA20402.1 - 1.7e-27 96.3 27.2 2.5e-26 92.4 23.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LapA_dom PF06305.11 EEA20402.1 - 0.18 11.7 0.6 2.1 8.2 0.0 3.0 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF1673 PF07895.11 EEA20402.1 - 0.22 11.2 4.2 2.7 7.6 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1673) APS_kinase PF01583.20 EEA20404.1 - 6.5e-72 240.6 0.0 8e-72 240.3 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EEA20404.1 - 1.5e-05 25.2 0.0 3.5e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA20404.1 - 5.8e-05 23.6 0.0 9.8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EEA20404.1 - 0.0047 16.4 0.0 0.0079 15.7 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EEA20404.1 - 0.0068 16.8 0.0 0.0078 16.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain NCD2 PF04905.13 EEA20404.1 - 0.0091 16.0 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) G-alpha PF00503.20 EEA20404.1 - 0.04 13.1 0.2 0.15 11.2 0.1 1.8 1 1 1 2 2 2 0 G-protein alpha subunit 6PF2K PF01591.18 EEA20404.1 - 0.045 13.1 0.0 0.21 10.9 0.0 1.9 2 0 0 2 2 2 0 6-phosphofructo-2-kinase AAA_29 PF13555.6 EEA20404.1 - 0.11 12.3 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain V-ATPase_C PF03223.15 EEA20405.1 - 4.5e-124 414.6 0.0 5.2e-124 414.4 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C 4HBT PF03061.22 EEA20406.1 - 4.2e-10 39.8 0.0 7.1e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DDE_3 PF13358.6 EEA20407.1 - 7.4e-13 48.5 0.1 2.1e-12 47.0 0.1 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA20407.1 - 6.5e-10 39.1 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA20407.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA20407.1 - 0.0078 16.1 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA20407.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA20407.1 - 0.012 16.0 0.1 13 6.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA20407.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA20407.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA20407.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA20407.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA20407.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 Ligase_CoA PF00549.19 EEA20408.1 - 3.1e-36 124.5 1.4 3e-19 69.3 0.2 2.4 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.19 EEA20408.1 - 1.1e-17 64.4 0.8 3.4e-17 62.9 0.1 2.2 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 EEA20408.1 - 1.6e-09 37.7 0.0 1.3e-05 25.0 0.0 2.6 2 0 0 2 2 2 2 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EEA20408.1 - 0.0056 17.2 0.4 0.033 14.7 0.1 2.5 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 EEA20408.1 - 0.083 12.4 0.0 0.63 9.6 0.0 2.4 2 1 0 2 2 2 0 ATP-grasp domain DUF648 PF04890.13 EEA20408.1 - 0.089 12.5 0.4 0.14 11.9 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF648) Zn_clus PF00172.18 EEA20409.1 - 7.2e-10 38.8 6.0 2.2e-09 37.3 6.0 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Jak1_Phl PF17887.1 EEA20410.1 - 1.1 9.2 6.6 0.17 11.8 0.9 2.1 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Jak1_Phl PF17887.1 EEA20411.1 - 1.3 9.0 6.9 0.16 11.9 0.9 2.1 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Rad60-SLD PF11976.8 EEA20412.1 - 2.9e-20 71.9 0.3 3.4e-20 71.7 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EEA20412.1 - 2.3e-11 43.3 0.1 2.6e-11 43.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Nup84_Nup100 PF04121.13 EEA20413.1 - 5.5e-145 484.3 9.6 1.1e-144 483.3 9.6 1.5 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 DUF2802 PF10975.8 EEA20413.1 - 0.028 14.5 3.2 1.1 9.4 1.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) SDA1 PF05285.12 EEA20413.1 - 0.3 10.5 17.4 0.55 9.6 17.4 1.4 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EEA20413.1 - 2.2 6.4 22.3 0.18 10.0 16.2 2.0 2 0 0 2 2 2 0 Nop14-like family HD PF01966.22 EEA20414.1 - 3e-06 27.5 0.0 4.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 HD domain Cation_ATPase_C PF00689.21 EEA20415.1 - 4.5e-45 153.6 15.5 9.1e-45 152.6 10.9 2.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EEA20415.1 - 2.1e-38 131.7 1.0 2.1e-38 131.7 1.0 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EEA20415.1 - 3.1e-22 78.5 0.1 8.5e-22 77.1 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EEA20415.1 - 8.7e-18 65.4 0.0 2.3e-17 64.0 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA20415.1 - 9.9e-09 34.8 0.1 3.8e-08 32.9 0.1 2.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EEA20415.1 - 1.3e-05 25.1 2.0 9.6e-05 22.2 1.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RskA PF10099.9 EEA20415.1 - 0.12 12.7 7.0 0.22 11.8 0.2 3.5 4 1 0 4 4 4 0 Anti-sigma-K factor rskA LptF_LptG PF03739.14 EEA20415.1 - 0.21 10.4 5.6 0.24 10.2 4.3 1.7 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG Tubulin PF00091.25 EEA20417.1 - 3.7e-68 229.6 0.0 6.5e-68 228.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EEA20417.1 - 1e-41 142.0 0.0 1.7e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EEA20417.1 - 2.7e-05 24.5 0.0 7.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EEA20417.1 - 0.0027 17.0 0.0 0.024 13.9 0.0 2.0 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EEA20417.1 - 0.0033 17.1 0.0 0.0061 16.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain TrmK PF04816.12 EEA20417.1 - 0.2 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase RRM_1 PF00076.22 EEA20418.1 - 4.2e-15 55.3 0.0 3.9e-06 26.6 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EEA20419.1 - 7e-12 45.0 0.0 1.5e-05 24.7 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 EEA20419.1 - 2.7 8.7 6.9 3.2 8.4 0.1 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EEA20420.1 - 1e-06 28.4 0.0 9.3e-06 25.4 0.0 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Porph_ging PF09697.10 EEA20420.1 - 0.37 11.4 1.7 0.88 10.1 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) U1snRNP70_N PF12220.8 EEA20420.1 - 0.96 10.1 6.5 2.1 9.1 0.1 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Ammonium_transp PF00909.21 EEA20421.1 - 1.6e-121 405.8 28.3 1.8e-121 405.6 28.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Pkinase PF00069.25 EEA20422.1 - 1e-66 225.0 0.0 2.4e-66 223.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20422.1 - 8.2e-36 123.6 0.0 4.6e-25 88.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA20422.1 - 9.3e-05 21.9 0.5 0.0052 16.1 0.5 2.6 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA20422.1 - 0.0021 16.9 0.0 0.004 16.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EEA20422.1 - 0.0022 18.0 0.0 0.0054 16.7 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EEA20422.1 - 0.0084 15.2 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 FtsX_ECD PF18075.1 EEA20422.1 - 0.066 13.8 0.0 0.29 11.8 0.0 2.2 1 0 0 1 1 1 0 FtsX extracellular domain FERM_f0 PF16511.5 EEA20422.1 - 0.07 13.5 0.1 0.25 11.7 0.1 1.9 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM Kdo PF06293.14 EEA20422.1 - 0.15 11.4 0.4 0.4 10.0 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DAGK_cat PF00781.24 EEA20423.1 - 7.6e-26 90.2 0.0 1.3e-25 89.5 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Adaptin_N PF01602.20 EEA20424.1 - 2.4e-99 333.3 9.9 3.9e-99 332.6 9.9 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EEA20424.1 - 8.5e-58 194.2 0.3 2.2e-57 192.9 0.3 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EEA20424.1 - 1.2e-56 190.2 0.0 3.4e-56 188.7 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EEA20424.1 - 4.6e-15 56.0 7.5 4.1e-11 43.2 0.1 3.0 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA20424.1 - 1.2e-10 41.6 2.3 5e-06 26.8 0.0 4.6 1 1 3 4 4 4 3 HEAT repeats HEAT_EZ PF13513.6 EEA20424.1 - 8.5e-05 23.0 0.2 0.074 13.6 0.0 4.6 3 1 1 4 4 4 2 HEAT-like repeat Coatomer_g_Cpla PF16381.5 EEA20424.1 - 9.4e-05 22.5 0.0 0.00045 20.3 0.0 2.2 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 EEA20424.1 - 0.00025 21.0 0.6 0.33 11.3 0.0 4.7 5 0 0 5 5 5 1 HEAT repeat API5 PF05918.11 EEA20424.1 - 0.00033 19.6 3.4 0.027 13.3 0.0 2.8 3 0 0 3 3 3 2 Apoptosis inhibitory protein 5 (API5) AP4E_app_platf PF14807.6 EEA20424.1 - 0.015 15.6 0.3 0.057 13.8 0.3 2.0 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform DUF5578 PF17741.1 EEA20424.1 - 0.021 14.2 1.7 2.6 7.4 0.0 2.8 1 1 0 2 2 2 0 Family of unknown function (DUF5578) Arm PF00514.23 EEA20424.1 - 0.089 12.9 4.1 1.1 9.3 0.0 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Mago_nashi PF02792.14 EEA20425.1 - 1.8e-70 235.6 0.1 2.1e-70 235.4 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein Mago_nashi PF02792.14 EEA20426.1 - 1.9e-72 242.0 0.1 2.1e-72 241.8 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein Mago_nashi PF02792.14 EEA20427.1 - 7.2e-45 152.6 0.2 8.7e-45 152.3 0.2 1.0 1 0 0 1 1 1 1 Mago nashi protein Vac_ImportDeg PF09783.9 EEA20428.1 - 1.3e-67 226.7 3.5 1.7e-67 226.3 3.5 1.2 1 0 0 1 1 1 1 Vacuolar import and degradation protein Nop52 PF05997.12 EEA20429.1 - 8e-56 189.2 0.6 7.2e-40 137.1 0.2 2.1 2 0 0 2 2 2 2 Nucleolar protein,Nop52 NOT2_3_5 PF04153.18 EEA20429.1 - 0.15 12.1 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 NOT2 / NOT3 / NOT5 family LRIF1 PF15741.5 EEA20429.1 - 0.32 9.5 4.0 0.51 8.8 4.0 1.2 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Afi1 PF07792.12 EEA20429.1 - 1.8 9.1 9.6 1.2 9.6 2.4 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TRAP_alpha PF03896.16 EEA20429.1 - 1.8 7.7 6.4 6.4 5.9 0.9 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit AP3D1 PF06375.11 EEA20429.1 - 2.9 8.1 17.9 4 7.7 9.5 2.3 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Connexin PF00029.19 EEA20429.1 - 6.6 6.4 4.7 0.55 10.0 0.1 1.5 2 0 0 2 2 2 0 Connexin UBD PF16455.5 EEA20430.1 - 4.7e-42 142.5 0.0 1e-41 141.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 EEA20430.1 - 5.1e-06 26.2 0.0 7.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EEA20430.1 - 7.6e-05 23.2 0.3 0.00022 21.8 0.0 1.8 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EEA20430.1 - 0.0069 16.2 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBD PF16455.5 EEA20431.1 - 4.6e-42 142.5 0.0 1e-41 141.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-binding domain DUF1604 PF07713.13 EEA20432.1 - 3.8e-44 148.4 4.5 1.1e-43 146.9 2.6 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EEA20432.1 - 6.5e-07 29.1 1.7 2e-06 27.6 1.7 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EEA20432.1 - 0.011 15.9 0.3 0.058 13.5 0.0 2.5 2 0 0 2 2 2 0 G-patch domain Pkinase PF00069.25 EEA20433.1 - 2.2e-70 237.1 0.0 3.1e-70 236.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20433.1 - 2.9e-40 138.2 0.0 6.6e-40 137.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EEA20433.1 - 9e-17 60.6 0.4 1.6e-16 59.8 0.4 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EEA20433.1 - 1e-05 25.0 0.0 0.00024 20.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EEA20433.1 - 1.9e-05 24.1 0.0 3.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EEA20433.1 - 0.00012 21.2 0.0 0.00019 20.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EEA20433.1 - 0.0012 18.8 0.1 0.0077 16.2 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EEA20433.1 - 0.073 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 EEA20433.1 - 0.085 12.4 0.2 0.22 11.1 0.2 1.7 1 1 0 1 1 1 0 RIO1 family ABC1 PF03109.16 EEA20433.1 - 0.15 12.3 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 ABC1 family SET PF00856.28 EEA20434.1 - 3.1e-17 63.5 0.0 1.5e-16 61.3 0.0 2.2 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 EEA20434.1 - 6e-14 52.6 3.0 6e-14 52.6 3.0 2.2 2 1 0 2 2 2 1 Pre-SET motif AWS PF17907.1 EEA20434.1 - 0.023 14.7 0.5 0.023 14.7 0.5 2.7 3 0 0 3 3 3 0 AWS domain Cellulase PF00150.18 EEA20436.1 - 6e-15 55.4 7.3 7.5e-15 55.1 7.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ion_trans PF00520.31 EEA20437.1 - 8e-121 401.9 90.0 5.2e-42 143.8 5.2 4.9 4 1 0 4 4 4 4 Ion transport protein GPHH PF16905.5 EEA20437.1 - 0.00036 20.2 0.0 0.0013 18.4 0.0 2.0 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_1 PF00036.32 EEA20437.1 - 0.016 14.7 0.0 0.038 13.5 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EEA20437.1 - 0.018 14.9 0.0 0.077 13.0 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain Proteasom_Rpn13 PF04683.13 EEA20438.1 - 9e-27 93.5 0.0 1.4e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EEA20438.1 - 6.7e-10 39.1 1.1 1.3e-08 34.9 1.1 2.4 1 1 0 1 1 1 1 UCH-binding domain Ribosomal_L6e PF01159.19 EEA20439.1 - 1.5e-39 135.0 0.3 1.5e-39 135.0 0.3 1.4 2 0 0 2 2 2 1 Ribosomal protein L6e ORC5_C PF14630.6 EEA20439.1 - 0.04 13.4 0.4 0.055 13.0 0.4 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus GNAT_acetyltr_2 PF13718.6 EEA20439.1 - 0.12 11.7 0.2 0.19 11.1 0.2 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FA_hydroxylase PF04116.13 EEA20440.1 - 6.4e-18 65.4 3.7 6.4e-18 65.4 3.7 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF3425 PF11905.8 EEA20441.1 - 1.7e-13 50.6 0.2 2e-12 47.2 0.2 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EEA20441.1 - 0.0033 17.5 19.1 0.15 12.2 19.2 2.2 1 1 0 1 1 1 1 bZIP transcription factor LCD1 PF09798.9 EEA20441.1 - 0.15 10.5 0.0 0.15 10.5 0.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein GLE1 PF07817.13 EEA20442.1 - 2.7e-46 157.8 0.0 7.2e-46 156.4 0.0 1.7 2 0 0 2 2 2 1 GLE1-like protein Caldesmon PF02029.15 EEA20442.1 - 0.97 8.1 51.6 1.3 7.7 51.6 1.1 1 0 0 1 1 1 0 Caldesmon Hid1 PF12722.7 EEA20442.1 - 4.1 5.4 19.6 5.2 5.1 19.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Velvet PF11754.8 EEA20442.1 - 7.3 6.4 6.2 12 5.7 6.2 1.3 1 0 0 1 1 1 0 Velvet factor GLE1 PF07817.13 EEA20443.1 - 2.7e-46 157.8 0.0 7.2e-46 156.4 0.0 1.7 2 0 0 2 2 2 1 GLE1-like protein Caldesmon PF02029.15 EEA20443.1 - 0.97 8.1 51.6 1.3 7.7 51.6 1.1 1 0 0 1 1 1 0 Caldesmon Hid1 PF12722.7 EEA20443.1 - 4.1 5.4 19.6 5.2 5.1 19.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Velvet PF11754.8 EEA20443.1 - 7.3 6.4 6.2 12 5.7 6.2 1.3 1 0 0 1 1 1 0 Velvet factor RNB PF00773.19 EEA20444.1 - 3.4e-89 299.4 0.1 7.7e-89 298.2 0.0 1.7 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 EEA20444.1 - 2e-26 91.8 0.1 7.3e-26 90.0 0.0 2.1 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 EEA20444.1 - 1.5e-25 89.3 0.0 4.9e-25 87.7 0.0 2.0 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 EEA20444.1 - 8.7e-05 22.6 0.0 0.028 14.6 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EEA20444.1 - 9.9e-05 22.1 0.0 0.00022 20.9 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain UQ_con PF00179.26 EEA20445.1 - 1.4e-33 115.5 0.0 2.4e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA20445.1 - 0.028 14.1 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EEA20445.1 - 0.059 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 RWD domain MMgT PF10270.9 EEA20450.1 - 1.6e-32 111.8 0.0 2e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter EF1_GNE PF00736.19 EEA20451.1 - 1.8e-33 114.5 3.5 1.8e-33 114.5 3.5 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EEA20451.1 - 2.1e-09 37.6 6.3 2.1e-09 37.6 6.3 2.6 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 EEA20451.1 - 8.2e-05 22.7 0.4 0.00016 21.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA20451.1 - 0.00047 20.3 0.9 0.0014 18.8 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA20451.1 - 0.016 15.2 0.1 0.17 12.0 0.1 2.3 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Thioesterase PF00975.20 EEA20451.1 - 0.033 14.3 0.1 0.051 13.7 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain DNA_pol3_a_NII PF11490.8 EEA20451.1 - 1.2 9.1 5.9 0.66 9.9 0.4 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II AAA_2 PF07724.14 EEA20452.1 - 4.6e-44 150.5 2.6 3.3e-43 147.7 0.0 3.0 4 0 0 4 4 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EEA20452.1 - 1.3e-35 121.5 2.2 1.3e-35 121.5 2.2 2.5 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EEA20452.1 - 9.3e-27 92.9 0.1 3.3e-26 91.1 0.1 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EEA20452.1 - 6.4e-19 68.7 0.8 2.6e-10 40.8 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA20452.1 - 1.7e-11 44.3 0.0 4.3e-07 30.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA20452.1 - 7.2e-10 39.5 2.8 0.00014 22.3 0.3 4.0 2 2 0 3 3 3 2 AAA ATPase domain Sigma54_activat PF00158.26 EEA20452.1 - 1.5e-06 28.0 0.3 0.0012 18.5 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EEA20452.1 - 1.6e-06 28.5 4.2 0.024 14.9 0.0 4.1 3 3 0 3 3 3 2 AAA domain AAA_14 PF13173.6 EEA20452.1 - 4.2e-06 26.8 0.0 0.017 15.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 EEA20452.1 - 9.8e-06 25.1 0.1 0.016 14.6 0.0 3.6 3 1 0 3 3 2 1 Bacterial TniB protein NACHT PF05729.12 EEA20452.1 - 1.4e-05 25.1 0.0 0.062 13.2 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_7 PF12775.7 EEA20452.1 - 4.6e-05 23.0 0.0 0.14 11.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 EEA20452.1 - 0.00011 22.0 0.0 0.23 11.2 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 EEA20452.1 - 0.00021 21.6 0.2 0.044 14.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EEA20452.1 - 0.00038 20.2 0.0 0.43 10.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EEA20452.1 - 0.0011 19.5 1.4 0.41 11.2 0.0 3.3 3 0 0 3 3 3 1 ABC transporter SRP54 PF00448.22 EEA20452.1 - 0.0012 18.5 0.1 0.18 11.4 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_18 PF13238.6 EEA20452.1 - 0.0013 19.3 1.1 3 8.4 0.0 3.1 3 0 0 3 3 2 2 AAA domain ResIII PF04851.15 EEA20452.1 - 0.0022 18.0 0.0 5.8 6.9 0.0 3.4 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EEA20452.1 - 0.0031 17.3 0.8 0.086 12.6 0.0 3.4 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.22 EEA20452.1 - 0.0039 17.6 0.1 2 8.8 0.0 2.9 2 1 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.21 EEA20452.1 - 0.0057 16.1 0.4 2.1 7.7 0.1 3.0 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI Roc PF08477.13 EEA20452.1 - 0.0071 16.6 0.0 2.7 8.3 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 EEA20452.1 - 0.0073 16.3 0.1 5.4 7.0 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 EEA20452.1 - 0.0078 16.0 0.0 0.41 10.4 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 EEA20452.1 - 0.008 16.1 9.2 2.6 7.9 0.0 4.4 3 2 1 5 5 5 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EEA20452.1 - 0.013 15.4 1.4 3.3 7.6 0.0 2.7 3 0 0 3 3 2 0 RsgA GTPase AAA_19 PF13245.6 EEA20452.1 - 0.026 14.9 3.1 0.17 12.2 0.4 3.1 2 2 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EEA20452.1 - 0.026 13.5 0.3 0.48 9.3 0.1 2.4 2 1 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF815 PF05673.13 EEA20452.1 - 0.027 13.6 0.6 0.4 9.8 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EEA20452.1 - 0.033 14.4 0.0 11 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA20452.1 - 0.035 13.7 0.2 0.58 9.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EEA20452.1 - 0.066 12.5 0.0 6.7 5.9 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_21 PF13304.6 EEA20452.1 - 0.067 13.0 2.4 0.97 9.2 0.0 3.1 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA20452.1 - 0.16 11.8 0.3 6.2 6.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain UvrD-helicase PF00580.21 EEA20452.1 - 0.21 11.1 4.3 0.64 9.5 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Rootletin PF15035.6 EEA20452.1 - 0.37 10.8 9.3 0.89 9.5 9.3 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion FAM76 PF16046.5 EEA20452.1 - 1.1 8.5 4.7 1.9 7.8 4.7 1.4 1 0 0 1 1 1 0 FAM76 protein CENP-H PF05837.12 EEA20452.1 - 7.9 6.9 10.9 20 5.6 10.9 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) MutS_V PF00488.21 EEA20453.1 - 1.2e-48 165.6 0.0 2.6e-48 164.5 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EEA20453.1 - 1.3e-19 71.1 0.1 3e-19 70.0 0.1 1.6 1 0 0 1 1 1 1 MutS domain III Sas10 PF09368.10 EEA20454.1 - 1.4e-28 99.1 10.6 1.4e-28 99.1 10.6 4.5 4 0 0 4 4 4 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EEA20454.1 - 8.6e-12 45.5 0.0 8.6e-12 45.5 0.0 3.5 3 1 0 3 3 3 1 Sas10/Utp3/C1D family adh_short PF00106.25 EEA20455.1 - 2.2e-20 72.9 0.0 3.5e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA20455.1 - 1.7e-13 50.7 0.0 2.5e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA20455.1 - 1.6e-09 38.0 0.1 2.5e-09 37.3 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA20455.1 - 4.4e-06 26.3 0.0 6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EEA20455.1 - 0.0002 20.7 0.0 0.00032 20.0 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 EEA20455.1 - 0.00021 20.8 0.0 0.00031 20.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EEA20455.1 - 0.0016 18.7 0.0 0.0024 18.1 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EEA20455.1 - 0.0092 15.1 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3HCDH_N PF02737.18 EEA20455.1 - 0.017 15.0 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Herpes_heli_pri PF05774.11 EEA20455.1 - 0.042 14.1 0.1 0.072 13.3 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component NAD_binding_10 PF13460.6 EEA20455.1 - 0.093 12.6 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 NAD(P)H-binding NAD_Gly3P_dh_N PF01210.23 EEA20455.1 - 0.12 12.3 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Spc7 PF08317.11 EEA20456.1 - 7.2e-05 21.8 70.7 0.029 13.2 14.3 4.4 3 1 1 4 4 4 4 Spc7 kinetochore protein PAM2 PF07145.15 EEA20456.1 - 0.022 14.4 8.8 0.085 12.6 0.0 3.9 4 0 0 4 4 4 0 Ataxin-2 C-terminal region Filament PF00038.21 EEA20456.1 - 0.39 10.2 77.8 7.4 6.1 10.1 4.7 2 1 1 3 3 3 0 Intermediate filament protein FliD_C PF07195.12 EEA20456.1 - 9.6 5.5 15.9 0.5 9.7 0.6 4.0 3 2 1 4 4 4 0 Flagellar hook-associated protein 2 C-terminus EMP24_GP25L PF01105.24 EEA20457.1 - 2.7e-47 161.1 0.8 3.2e-47 160.8 0.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EMP24_GP25L PF01105.24 EEA20458.1 - 2.5e-47 161.2 0.8 2.9e-47 160.9 0.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Acyl-CoA_dh_M PF02770.19 EEA20459.1 - 4.9e-19 68.3 0.0 7.7e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EEA20459.1 - 7e-09 36.0 0.1 1.1e-08 35.4 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA20459.1 - 0.086 13.5 0.0 0.45 11.2 0.0 2.1 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Metallophos PF00149.28 EEA20460.1 - 5.5e-10 40.1 2.5 9.5e-10 39.3 2.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase adh_short PF00106.25 EEA20461.1 - 2.9e-15 56.2 0.1 4.9e-14 52.2 0.0 2.4 3 0 0 3 3 3 1 short chain dehydrogenase KR PF08659.10 EEA20461.1 - 4.7e-06 26.6 0.1 8.5e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EEA20461.1 - 1.6e-05 24.6 0.0 3.3e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF3237 PF11578.8 EEA20462.1 - 7.7e-47 158.9 0.2 8.6e-47 158.7 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) DUF3237 PF11578.8 EEA20463.1 - 2.9e-36 124.5 0.3 3.2e-36 124.4 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) 14-3-3 PF00244.20 EEA20464.1 - 4.2e-08 33.0 0.1 7.7e-08 32.1 0.1 1.4 1 0 0 1 1 1 1 14-3-3 protein adh_short_C2 PF13561.6 EEA20465.1 - 2.3e-57 194.3 0.3 2.8e-57 194.0 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA20465.1 - 5.7e-47 159.7 0.1 7.5e-47 159.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA20465.1 - 4e-11 43.2 0.1 5.9e-11 42.6 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA20465.1 - 0.00011 21.8 0.1 0.00045 19.8 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family CHORD PF04968.12 EEA20466.1 - 9.9e-52 173.5 19.9 1.6e-27 96.0 7.4 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.16 EEA20466.1 - 8.2e-14 52.4 0.0 1.4e-13 51.7 0.0 1.4 1 0 0 1 1 1 1 CS domain AXH PF08517.12 EEA20466.1 - 0.01 16.4 0.6 8.8 6.9 0.0 3.1 3 0 0 3 3 3 0 Ataxin-1 and HBP1 module (AXH) BTK PF00779.19 EEA20466.1 - 4.1 7.3 13.7 7.3 6.5 1.0 3.6 2 1 0 2 2 2 0 BTK motif DUF836 PF05768.14 EEA20467.1 - 1.7e-14 54.0 0.1 2e-14 53.8 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EEA20467.1 - 0.0025 18.0 0.1 0.004 17.4 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin DUF3405 PF11885.8 EEA20468.1 - 4.7e-230 764.6 0.4 5.7e-230 764.3 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Pyr_redox_3 PF13738.6 EEA20469.1 - 5.4e-26 91.6 0.0 5.2e-24 85.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EEA20469.1 - 9.9e-21 73.7 0.0 1.1e-18 67.0 0.0 2.3 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EEA20469.1 - 2.1e-19 69.9 0.0 2.9e-15 56.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA20469.1 - 1.7e-15 57.0 0.7 8.3e-12 44.9 0.8 3.1 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EEA20469.1 - 8e-10 38.5 0.4 4.3e-06 26.2 0.2 3.0 2 1 1 3 3 3 2 FAD binding domain Pyr_redox PF00070.27 EEA20469.1 - 1.1e-09 38.8 0.2 0.0098 16.4 0.0 3.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EEA20469.1 - 3.2e-09 36.4 0.3 0.0012 18.2 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EEA20469.1 - 6.4e-07 29.5 0.0 2e-05 24.7 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA20469.1 - 2.8e-06 27.4 0.2 0.57 10.1 0.0 4.0 3 1 1 4 4 4 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EEA20469.1 - 1.6e-05 24.1 0.0 0.0054 15.8 0.0 3.5 4 0 0 4 4 4 1 Lycopene cyclase protein ApbA PF02558.16 EEA20469.1 - 1.7e-05 24.5 0.0 0.03 13.9 0.0 2.6 3 0 0 3 3 2 2 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EEA20469.1 - 2.6e-05 24.6 0.0 0.012 16.1 0.0 2.7 3 0 0 3 3 2 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 EEA20469.1 - 3.1e-05 24.0 0.1 0.078 12.9 0.1 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EEA20469.1 - 3.7e-05 23.0 0.0 0.03 13.4 0.0 3.1 3 0 0 3 3 3 1 Glucose inhibited division protein A F420_oxidored PF03807.17 EEA20469.1 - 3.9e-05 24.1 0.0 3.3 8.4 0.0 3.6 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent HI0933_like PF03486.14 EEA20469.1 - 6.1e-05 21.9 0.0 0.021 13.6 0.0 3.1 3 0 0 3 3 3 1 HI0933-like protein IlvN PF07991.12 EEA20469.1 - 0.00016 21.3 0.0 0.0034 17.0 0.1 2.3 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_binding_2 PF00890.24 EEA20469.1 - 0.00019 20.7 0.0 0.0077 15.4 0.1 2.8 3 0 0 3 3 3 1 FAD binding domain Shikimate_DH PF01488.20 EEA20469.1 - 0.0002 21.4 0.0 0.24 11.5 0.0 2.5 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EEA20469.1 - 0.00053 19.3 0.0 0.13 11.6 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EEA20469.1 - 0.00064 19.4 1.7 0.22 11.0 0.1 2.7 1 1 1 2 2 2 2 FAD dependent oxidoreductase TrkA_N PF02254.18 EEA20469.1 - 0.0017 18.6 1.9 0.56 10.5 0.0 3.1 4 0 0 4 4 2 1 TrkA-N domain NAD_binding_2 PF03446.15 EEA20469.1 - 0.0029 17.8 0.1 2.2 8.4 0.1 2.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase FAD_oxidored PF12831.7 EEA20469.1 - 0.0053 16.2 0.2 0.19 11.1 0.1 2.7 2 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA20469.1 - 0.0098 15.2 0.2 2.6 7.2 0.0 3.5 4 0 0 4 4 4 1 Thi4 family XdhC_C PF13478.6 EEA20469.1 - 0.014 15.9 0.0 0.49 10.9 0.0 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_Gly3P_dh_N PF01210.23 EEA20469.1 - 0.025 14.6 0.0 0.96 9.4 0.0 2.7 3 0 0 3 3 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ThiF PF00899.21 EEA20469.1 - 0.043 13.2 0.0 2.6 7.4 0.0 2.3 2 0 0 2 2 2 0 ThiF family adh_short PF00106.25 EEA20469.1 - 0.052 13.0 0.0 10 5.5 0.0 2.3 2 0 0 2 2 2 0 short chain dehydrogenase ELFV_dehydrog PF00208.21 EEA20469.1 - 0.28 10.9 0.9 0.71 9.6 0.2 1.8 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Sod_Cu PF00080.20 EEA20470.1 - 2.5e-09 37.4 0.1 9.5e-09 35.6 0.1 1.9 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Fungal_trans_2 PF11951.8 EEA20470.1 - 0.051 12.4 0.1 0.059 12.2 0.1 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain Sugar_tr PF00083.24 EEA20471.1 - 6.6e-89 298.8 17.4 8e-89 298.6 17.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA20471.1 - 4.7e-32 111.3 40.5 1.3e-23 83.5 18.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LMBR1 PF04791.16 EEA20471.1 - 0.031 13.2 4.5 0.023 13.7 2.8 1.5 2 0 0 2 2 2 0 LMBR1-like membrane protein Choline_kinase PF01633.20 EEA20472.1 - 5.2e-47 160.2 0.0 8.6e-46 156.2 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EEA20472.1 - 4.1e-09 36.7 0.1 1.4e-08 35.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA20473.1 - 5.2e-47 160.2 0.0 8.6e-46 156.2 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EEA20473.1 - 4.1e-09 36.7 0.1 1.4e-08 35.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Arf PF00025.21 EEA20474.1 - 4.4e-79 264.0 0.5 5.2e-79 263.7 0.5 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA20474.1 - 3e-14 53.3 0.0 4.3e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EEA20474.1 - 3.9e-14 52.5 0.0 4.9e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EEA20474.1 - 2.2e-13 50.2 0.0 2.4e-13 50.0 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EEA20474.1 - 2.2e-13 50.1 1.3 1.9e-09 37.1 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EEA20474.1 - 2.5e-10 40.1 0.0 3e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA20474.1 - 4.2e-06 26.8 0.0 6.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EEA20474.1 - 0.01 15.1 0.5 0.028 13.7 0.1 1.7 1 1 0 2 2 2 0 6-phosphofructo-2-kinase Arf PF00025.21 EEA20475.1 - 4.4e-79 264.0 0.5 5.2e-79 263.7 0.5 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA20475.1 - 3e-14 53.3 0.0 4.3e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EEA20475.1 - 3.9e-14 52.5 0.0 4.9e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EEA20475.1 - 2.2e-13 50.2 0.0 2.4e-13 50.0 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EEA20475.1 - 2.2e-13 50.1 1.3 1.9e-09 37.1 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EEA20475.1 - 2.5e-10 40.1 0.0 3e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA20475.1 - 4.2e-06 26.8 0.0 6.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EEA20475.1 - 0.01 15.1 0.5 0.028 13.7 0.1 1.7 1 1 0 2 2 2 0 6-phosphofructo-2-kinase HTH_35 PF13693.6 EEA20476.1 - 0.085 12.9 0.0 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding SieB PF14163.6 EEA20476.1 - 0.1 12.1 1.5 0.26 10.8 1.5 1.6 1 0 0 1 1 1 0 Super-infection exclusion protein B CorA PF01544.18 EEA20476.1 - 0.14 11.4 5.3 0.94 8.7 0.6 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Ribosomal_L1 PF00687.21 EEA20477.1 - 1.3e-44 152.4 0.1 1.5e-44 152.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SNF PF00209.18 EEA20477.1 - 0.037 12.7 0.0 0.051 12.3 0.0 1.1 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family WH2 PF02205.20 EEA20479.1 - 1.9e-09 37.1 0.7 3.4e-09 36.2 0.1 1.8 2 0 0 2 2 2 1 WH2 motif CAP_N PF01213.19 EEA20479.1 - 0.018 14.6 14.2 0.018 14.6 14.2 9.3 2 2 5 7 7 7 0 Adenylate cyclase associated (CAP) N terminal LSM PF01423.22 EEA20480.1 - 8.8e-17 60.6 0.1 1.4e-16 59.9 0.1 1.3 1 0 0 1 1 1 1 LSM domain HLH PF00010.26 EEA20482.1 - 7.6e-14 51.4 0.6 1.5e-13 50.5 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IU_nuc_hydro PF01156.19 EEA20483.1 - 5e-59 200.4 0.0 7.1e-59 199.9 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Transketolase_C PF02780.20 EEA20483.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Transketolase, C-terminal domain OCD_Mu_crystall PF02423.15 EEA20485.1 - 1.4e-14 53.7 0.0 3.7e-07 29.4 0.0 2.0 2 0 0 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EEA20485.1 - 0.00013 22.1 0.0 1.1 9.4 0.0 3.1 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase Fungal_trans PF04082.18 EEA20486.1 - 1.1e-12 47.5 0.0 2.4e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20486.1 - 9.2e-09 35.3 11.7 1.7e-08 34.5 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4769 PF15992.5 EEA20486.1 - 0.19 11.5 1.1 0.31 10.8 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4769) NBP1 PF08537.10 EEA20486.1 - 4.7 6.5 8.0 87 2.4 0.0 2.2 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 Fungal_trans PF04082.18 EEA20487.1 - 3.8e-18 65.5 0.1 5.6e-18 64.9 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20487.1 - 7.7e-08 32.3 8.0 7.7e-08 32.3 8.0 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5345 PF17280.2 EEA20488.1 - 0.082 12.9 0.1 0.57 10.2 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Rox3 PF08633.10 EEA20489.1 - 6.1e-62 209.6 1.0 6.1e-62 209.6 1.0 1.6 2 0 0 2 2 2 1 Rox3 mediator complex subunit SPT6_acidic PF14632.6 EEA20489.1 - 0.046 14.3 1.3 0.12 12.9 1.3 1.8 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Hamartin PF04388.12 EEA20489.1 - 0.069 11.8 7.6 0.11 11.1 7.6 1.3 1 0 0 1 1 1 0 Hamartin protein Hydrolase PF00702.26 EEA20490.1 - 0.00012 22.5 0.0 0.00027 21.3 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA20490.1 - 0.0002 21.5 0.0 0.022 14.8 0.0 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase CsbD PF05532.12 EEA20490.1 - 0.16 11.9 2.0 0.87 9.5 0.1 2.3 2 0 0 2 2 2 0 CsbD-like DUF4202 PF13875.6 EEA20491.1 - 4.3e-80 268.0 2.0 4.9e-80 267.8 2.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) VIT1 PF01988.19 EEA20492.1 - 1.7e-59 201.3 4.4 2.1e-59 201.0 4.4 1.1 1 0 0 1 1 1 1 VIT family SLATT_fungal PF18142.1 EEA20492.1 - 0.12 12.3 0.1 0.33 10.9 0.1 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Fungal_trans_2 PF11951.8 EEA20493.1 - 2.5e-09 36.4 0.0 3.7e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20493.1 - 0.0013 18.8 4.5 0.0045 17.1 4.5 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ECSIT PF06239.11 EEA20494.1 - 0.042 13.0 0.0 0.052 12.7 0.0 1.1 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway AA_permease PF00324.21 EEA20495.1 - 3.5e-05 22.6 0.4 0.0002 20.1 0.4 1.9 1 1 0 1 1 1 1 Amino acid permease FMO-like PF00743.19 EEA20496.1 - 8.8e-16 57.4 0.0 7.6e-13 47.7 0.0 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EEA20496.1 - 2.5e-10 40.1 0.0 4.9e-08 32.6 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA20496.1 - 5.8e-08 32.3 0.1 0.00058 19.2 0.0 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA20496.1 - 1.1e-07 31.9 0.0 4.6e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EEA20496.1 - 4.2e-07 29.4 0.0 6.9e-05 22.1 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EEA20496.1 - 6.6e-05 23.1 0.0 0.00079 19.6 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA20496.1 - 0.014 15.9 0.0 8.5 7.0 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA20496.1 - 0.074 12.3 0.3 0.27 10.4 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 EEA20496.1 - 0.21 10.8 0.3 0.54 9.5 0.0 1.7 2 0 0 2 2 2 0 Thi4 family SURF4 PF02077.15 EEA20497.1 - 1.5e-96 323.1 8.0 1.7e-96 322.9 8.0 1.0 1 0 0 1 1 1 1 SURF4 family UPF0139 PF03669.13 EEA20497.1 - 9.2 6.2 8.3 0.27 11.1 0.8 2.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0139) SGL PF08450.12 EEA20498.1 - 4.3e-39 134.6 0.0 5.3e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EEA20498.1 - 4.2e-06 26.5 7.4 0.04 14.0 0.0 5.6 7 1 0 7 7 7 3 NHL repeat Str_synth PF03088.16 EEA20498.1 - 4.6e-05 23.5 0.0 0.07 13.3 0.0 3.4 2 1 0 2 2 2 1 Strictosidine synthase Arylesterase PF01731.20 EEA20498.1 - 0.019 15.1 0.0 0.21 11.8 0.0 2.6 3 0 0 3 3 3 0 Arylesterase MFS_1 PF07690.16 EEA20499.1 - 1.2e-29 103.3 25.6 1.6e-29 102.9 25.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20499.1 - 2.4e-18 66.2 19.1 3.4e-18 65.7 19.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DUF4131 PF13567.6 EEA20499.1 - 1.3 8.6 3.9 22 4.6 0.1 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) DUF2207 PF09972.9 EEA20499.1 - 4 6.1 9.6 0.19 10.5 2.5 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) TauE PF01925.19 EEA20499.1 - 4.4 6.9 29.0 1.1 8.9 7.3 3.5 1 1 2 3 3 3 0 Sulfite exporter TauE/SafE NMT1 PF09084.11 EEA20500.1 - 2.8e-10 40.5 0.0 3.4e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 EEA20500.1 - 9.5e-06 25.2 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_2 PF13379.6 EEA20500.1 - 0.00095 18.9 0.0 0.0023 17.7 0.0 1.6 2 0 0 2 2 2 1 NMT1-like family Phosphonate-bd PF12974.7 EEA20500.1 - 0.0016 18.0 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein Fungal_trans PF04082.18 EEA20501.1 - 4.2e-17 62.1 0.4 8.3e-17 61.1 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20501.1 - 0.029 14.5 1.4 0.057 13.5 1.4 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Polysacc_deac_1 PF01522.21 EEA20502.1 - 0.00057 19.8 0.0 0.0013 18.6 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase VPS9 PF02204.18 EEA20504.1 - 5.8e-31 106.8 0.0 1.1e-30 106.0 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EEA20504.1 - 5.2e-15 55.5 0.1 1.8e-14 53.8 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EEA20504.1 - 2.6e-09 36.6 0.1 3.3e-08 33.1 0.0 2.3 2 0 0 2 2 2 1 CUE domain HCMV_UL124 PF17609.2 EEA20504.1 - 0.039 14.2 2.6 0.066 13.4 0.5 2.2 2 0 0 2 2 2 0 Family of unknown function SCIMP PF15050.6 EEA20504.1 - 0.38 11.2 1.4 0.8 10.2 0.2 2.2 2 0 0 2 2 2 0 SCIMP protein VPS9 PF02204.18 EEA20505.1 - 5.7e-31 106.8 0.0 1e-30 106.0 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EEA20505.1 - 5e-15 55.6 0.1 1.7e-14 53.8 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EEA20505.1 - 7.4e-05 22.4 0.1 0.00093 18.9 0.0 2.3 2 0 0 2 2 2 1 CUE domain HCMV_UL124 PF17609.2 EEA20505.1 - 0.039 14.2 2.6 0.064 13.4 0.5 2.2 2 0 0 2 2 2 0 Family of unknown function SCIMP PF15050.6 EEA20505.1 - 0.37 11.3 1.4 0.78 10.2 0.2 2.2 2 0 0 2 2 2 0 SCIMP protein VPS9 PF02204.18 EEA20506.1 - 1e-27 96.4 0.0 2e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EEA20506.1 - 4e-15 55.9 0.1 1.2e-14 54.4 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) VPS9 PF02204.18 EEA20507.1 - 5.3e-31 106.9 0.0 9.7e-31 106.1 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EEA20507.1 - 4.8e-15 55.6 0.1 1.7e-14 53.9 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) HCMV_UL124 PF17609.2 EEA20507.1 - 0.035 14.3 2.6 0.06 13.5 0.5 2.2 2 0 0 2 2 2 0 Family of unknown function Asn_synthase PF00733.21 EEA20508.1 - 4.1e-13 49.7 0.1 0.00045 20.0 0.0 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 EEA20508.1 - 3.5e-06 26.9 0.0 2.2e-05 24.3 0.0 2.2 1 1 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EEA20508.1 - 0.065 12.7 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Aluminium induced protein GATase_6 PF13522.6 EEA20508.1 - 0.081 13.1 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Glutamine amidotransferase domain Cu_amine_oxid PF01179.20 EEA20509.1 - 3e-160 533.7 0.5 3.6e-160 533.4 0.5 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EEA20509.1 - 1.6e-09 37.9 0.2 3e-09 37.0 0.2 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EEA20509.1 - 2.2e-06 28.0 0.0 5.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain PNP_UDP_1 PF01048.20 EEA20510.1 - 7.2e-08 32.0 0.2 2e-07 30.5 0.2 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily bZIP_2 PF07716.15 EEA20511.1 - 1.2e-06 28.5 7.8 1.9e-06 27.9 7.8 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EEA20511.1 - 1e-05 25.5 6.1 1.5e-05 25.0 6.1 1.2 1 0 0 1 1 1 1 bZIP transcription factor DUF5102 PF17104.5 EEA20511.1 - 0.0084 16.2 1.8 0.012 15.7 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) PKcGMP_CC PF16808.5 EEA20511.1 - 0.016 15.0 0.2 0.016 15.0 0.2 1.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GreA_GreB_N PF03449.15 EEA20511.1 - 0.11 12.7 2.3 0.17 12.0 2.3 1.3 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal PH_6 PF15406.6 EEA20513.1 - 2e-37 127.9 5.0 2e-37 127.9 5.0 3.3 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 EEA20513.1 - 4.4e-06 27.2 0.0 2e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 PH domain PH_4 PF15404.6 EEA20513.1 - 0.096 12.5 0.0 0.096 12.5 0.0 2.6 3 0 0 3 3 3 0 Pleckstrin homology domain Sulfate_transp PF00916.20 EEA20514.1 - 2.4e-61 207.6 25.3 3.7e-61 207.0 25.3 1.3 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 EEA20514.1 - 4.3e-15 55.6 0.0 8.2e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 EEA20514.1 - 2.2e-12 46.6 0.2 4.3e-12 45.7 0.2 1.4 1 0 0 1 1 1 1 STAS domain Dicty_CAR PF05462.11 EEA20514.1 - 0.0052 15.9 2.4 0.0095 15.1 2.4 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor DUF5389 PF17364.2 EEA20514.1 - 0.023 14.7 0.9 0.07 13.2 0.9 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5389) SUIM_assoc PF16619.5 EEA20514.1 - 5.9 7.0 8.4 0.49 10.5 2.5 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Sld5 PF05916.11 EEA20515.1 - 3e-14 53.4 0.1 5.5e-14 52.6 0.1 1.5 1 1 0 1 1 1 1 GINS complex protein HMG_box PF00505.19 EEA20516.1 - 9.9e-10 38.7 1.0 1.8e-09 37.9 1.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box MATalpha_HMGbox PF04769.12 EEA20516.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Pap_E4 PF02711.14 EEA20516.1 - 6.2 7.9 11.8 0.44 11.5 3.6 3.1 2 2 1 3 3 3 0 E4 protein PHD PF00628.29 EEA20517.1 - 3.5e-07 30.0 13.2 8e-07 28.9 13.2 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EEA20517.1 - 0.24 11.0 12.4 0.076 12.6 8.7 2.0 2 0 0 2 2 2 0 PHD-finger Rcd1 PF04078.13 EEA20518.1 - 2.6e-126 420.2 3.2 3.2e-126 419.9 3.2 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like TAF4 PF05236.14 EEA20518.1 - 0.004 17.0 6.2 0.0062 16.3 6.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family baeRF_family10 PF18854.1 EEA20518.1 - 0.077 13.2 11.2 0.62 10.3 7.8 2.5 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 EPL1 PF10513.9 EEA20518.1 - 0.64 10.4 2.9 0.93 9.9 2.9 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like CnrY PF17524.2 EEA20518.1 - 0.85 9.9 4.6 1.2 9.5 0.0 2.5 2 0 0 2 2 2 0 Anti-sigma factor CnrY Spond_N PF06468.13 EEA20518.1 - 0.87 9.7 5.1 2.3 8.3 4.5 1.8 2 0 0 2 2 2 0 Spondin_N TFIIA PF03153.13 EEA20518.1 - 3.9 7.4 16.8 4.8 7.1 16.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CYYR1 PF10873.8 EEA20519.1 - 0.00062 20.2 0.1 0.00062 20.2 0.1 2.4 2 0 0 2 2 2 1 Cysteine and tyrosine-rich protein 1 Glycophorin_A PF01102.18 EEA20519.1 - 0.009 16.2 1.4 0.015 15.6 0.7 1.8 1 1 0 1 1 1 1 Glycophorin A DUF202 PF02656.15 EEA20519.1 - 0.018 15.5 1.1 1.2 9.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF202) EphA2_TM PF14575.6 EEA20519.1 - 0.11 13.4 0.0 21 6.1 0.0 2.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Lipase_3 PF01764.25 EEA20520.1 - 1.1e-06 28.6 0.0 2.7e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EEA20520.1 - 0.074 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 p450 PF00067.22 EEA20521.1 - 4.5e-40 137.8 0.0 6.1e-40 137.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 MBOAT_2 PF13813.6 EEA20522.1 - 2.9e-22 78.7 1.2 2.9e-22 78.7 1.2 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family MFS_1 PF07690.16 EEA20523.1 - 1.1e-39 136.4 51.1 4e-39 134.5 49.0 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EEA20523.1 - 0.0024 16.2 2.8 0.0024 16.2 2.8 2.4 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EEA20524.1 - 1.3e-33 116.4 39.7 1.3e-33 116.4 39.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20524.1 - 1.5e-10 40.5 4.4 1.5e-10 40.5 4.4 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EEA20524.1 - 2.9e-06 26.0 5.0 4.6e-06 25.3 5.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) adh_short PF00106.25 EEA20525.1 - 3.1e-33 114.9 0.0 4.2e-33 114.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA20525.1 - 5e-19 68.8 0.0 6.4e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA20525.1 - 6.7e-05 22.9 0.0 9.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA20525.1 - 0.0011 18.5 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family p450 PF00067.22 EEA20526.1 - 2.4e-50 171.6 0.0 3.2e-50 171.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EEA20527.1 - 6e-34 117.6 0.1 6.8e-34 117.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EEA20528.1 - 8e-48 162.5 0.2 9.7e-48 162.2 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA20528.1 - 1.1e-41 142.9 0.2 1.9e-40 138.9 0.2 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA20528.1 - 1.3e-06 28.5 1.3 1.8e-05 24.7 1.3 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA20528.1 - 0.00016 21.3 0.0 0.00031 20.3 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EEA20528.1 - 0.0097 15.6 0.7 0.035 13.9 0.7 1.9 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase p450 PF00067.22 EEA20529.1 - 4.2e-26 91.7 0.0 1.6e-21 76.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Tri3 PF07428.11 EEA20530.1 - 0.00014 21.0 0.0 0.0046 15.9 0.0 2.2 1 1 1 2 2 2 2 15-O-acetyltransferase Tri3 Condensation PF00668.20 EEA20530.1 - 0.024 13.3 0.0 0.044 12.5 0.0 1.4 1 0 0 1 1 1 0 Condensation domain adh_short PF00106.25 EEA20531.1 - 5.7e-37 127.1 0.1 7.6e-37 126.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA20531.1 - 5.3e-29 101.4 0.1 2.4e-28 99.3 0.1 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA20531.1 - 1.2e-09 38.3 0.1 1.6e-09 37.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA20531.1 - 0.0016 17.6 0.1 0.002 17.3 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein EthD PF07110.11 EEA20532.1 - 3.4e-22 79.4 0.1 4.1e-22 79.1 0.1 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EEA20532.1 - 4e-07 30.5 0.0 5.1e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase p450 PF00067.22 EEA20533.1 - 2.8e-25 89.0 0.0 1.2e-24 86.9 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Granulin PF00396.18 EEA20534.1 - 3.8 7.9 16.6 3.7 7.9 1.0 3.7 2 1 1 3 3 3 0 Granulin Mito_carr PF00153.27 EEA20535.1 - 2.5e-53 177.9 2.4 1.3e-18 66.7 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NmrA PF05368.13 EEA20537.1 - 8.9e-30 104.0 0.3 1.3e-29 103.4 0.3 1.3 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA20537.1 - 2.6e-12 47.0 0.0 5.8e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EEA20537.1 - 2.7e-05 24.4 0.5 0.012 15.9 0.0 2.4 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain CbiJ PF02571.14 EEA20537.1 - 0.076 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK KR PF08659.10 EEA20537.1 - 0.092 12.7 0.2 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 KR domain NmrA PF05368.13 EEA20538.1 - 8.9e-30 104.0 0.3 1.3e-29 103.4 0.3 1.3 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA20538.1 - 2.6e-12 47.0 0.0 5.8e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EEA20538.1 - 2.7e-05 24.4 0.5 0.012 15.9 0.0 2.4 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain CbiJ PF02571.14 EEA20538.1 - 0.076 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK KR PF08659.10 EEA20538.1 - 0.092 12.7 0.2 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 KR domain BIV_Env PF05858.12 EEA20539.1 - 0.0022 16.3 0.2 0.0031 15.8 0.2 1.2 1 0 0 1 1 1 1 Bovine immunodeficiency virus surface protein (SU) Presenilin PF01080.17 EEA20539.1 - 0.18 10.5 3.3 0.3 9.8 3.3 1.5 1 0 0 1 1 1 0 Presenilin Prefoldin_2 PF01920.20 EEA20540.1 - 6.6e-21 74.3 4.7 8e-21 74.0 4.7 1.2 1 0 0 1 1 1 1 Prefoldin subunit FlxA PF14282.6 EEA20540.1 - 0.0016 18.4 6.6 0.28 11.2 0.2 2.3 2 0 0 2 2 2 2 FlxA-like protein CCDC-167 PF15188.6 EEA20540.1 - 0.014 15.7 1.5 0.029 14.7 1.4 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Fib_alpha PF08702.10 EEA20540.1 - 0.015 15.5 4.2 0.078 13.2 0.2 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SMODS PF18144.1 EEA20540.1 - 0.015 15.5 0.7 0.018 15.2 0.7 1.1 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain DUF5082 PF16888.5 EEA20540.1 - 0.051 13.9 5.6 0.95 9.8 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Swi5 PF07061.11 EEA20540.1 - 0.056 13.5 8.4 0.47 10.6 1.2 2.1 2 0 0 2 2 2 0 Swi5 DUF4200 PF13863.6 EEA20540.1 - 0.069 13.6 4.3 0.84 10.0 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) HMMR_N PF15905.5 EEA20540.1 - 0.076 12.5 4.5 0.11 11.9 4.5 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal T6PP_N PF18572.1 EEA20540.1 - 0.08 12.8 3.6 0.27 11.1 3.6 1.9 1 1 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain ZapB PF06005.12 EEA20540.1 - 0.11 13.0 0.4 0.11 13.0 0.4 2.1 2 1 0 2 2 2 0 Cell division protein ZapB SlyX PF04102.12 EEA20540.1 - 0.63 10.7 6.9 4 8.1 2.5 2.3 2 1 0 2 2 2 0 SlyX YabA PF06156.13 EEA20540.1 - 3 8.5 5.7 3 8.5 0.7 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Csm1_N PF18504.1 EEA20540.1 - 8.1 6.9 9.2 2.3 8.6 1.1 2.6 2 1 1 3 3 3 0 Csm1 N-terminal domain Apq12 PF12716.7 EEA20541.1 - 3.2e-19 68.6 18.5 3.2e-19 68.6 18.5 1.6 2 0 0 2 2 2 1 Nuclear pore assembly and biogenesis ATP_bind_1 PF03029.17 EEA20542.1 - 1.3e-74 251.0 0.0 4e-74 249.4 0.0 1.6 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 EEA20542.1 - 0.00012 22.1 0.0 0.0003 20.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA20542.1 - 0.00041 20.8 0.0 0.0018 18.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain CLP1_P PF16575.5 EEA20542.1 - 0.00069 19.5 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA PF00004.29 EEA20542.1 - 0.0014 19.1 0.0 0.0037 17.7 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EEA20542.1 - 0.0016 17.6 0.0 0.0025 16.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EEA20542.1 - 0.0022 18.3 0.0 0.0049 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA20542.1 - 0.0022 18.3 0.1 0.023 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EEA20542.1 - 0.0024 17.6 0.0 0.0047 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA20542.1 - 0.0035 17.9 0.0 0.0076 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EEA20542.1 - 0.0054 17.3 0.0 0.02 15.4 0.0 1.8 2 0 0 2 2 2 1 ABC transporter RNA_helicase PF00910.22 EEA20542.1 - 0.0055 17.1 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 EEA20542.1 - 0.007 15.9 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 EEA20542.1 - 0.015 15.0 0.0 0.038 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EEA20542.1 - 0.017 15.0 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 EEA20542.1 - 0.019 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EEA20542.1 - 0.019 14.9 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 EEA20542.1 - 0.021 14.0 0.1 0.081 12.1 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.6 EEA20542.1 - 0.025 14.7 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA20542.1 - 0.028 14.4 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_29 PF13555.6 EEA20542.1 - 0.034 13.9 0.0 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA20542.1 - 0.035 14.2 0.0 0.076 13.1 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase Sigma54_activat PF00158.26 EEA20542.1 - 0.036 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Septin PF00735.18 EEA20542.1 - 0.039 13.2 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 EEA20542.1 - 0.044 13.7 0.1 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase ATPase PF06745.13 EEA20542.1 - 0.044 13.1 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 KaiC SRP54 PF00448.22 EEA20542.1 - 0.054 13.1 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain cobW PF02492.19 EEA20542.1 - 0.055 13.1 0.1 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Thymidylate_kin PF02223.17 EEA20542.1 - 0.074 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Thymidylate kinase GTP_EFTU PF00009.27 EEA20542.1 - 0.082 12.4 0.0 5 6.6 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_31 PF13614.6 EEA20542.1 - 0.086 12.8 0.0 5.4 6.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EEA20542.1 - 0.087 12.0 0.0 0.089 12.0 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain PduV-EutP PF10662.9 EEA20542.1 - 0.11 12.2 0.0 0.38 10.5 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 EEA20542.1 - 0.13 12.7 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA20542.1 - 0.13 12.0 0.1 0.31 10.8 0.0 1.6 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 EEA20542.1 - 0.14 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) S-AdoMet_synt_C PF02773.16 EEA20543.1 - 5.5e-67 224.0 0.4 2.2e-66 222.1 0.1 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 EEA20543.1 - 8e-44 148.4 0.8 1.3e-43 147.7 0.1 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 EEA20543.1 - 1.5e-43 147.8 0.0 3e-43 146.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain SLD3 PF08639.10 EEA20544.1 - 8.2e-162 539.7 18.9 8.2e-162 539.7 18.9 2.0 2 0 0 2 2 2 1 DNA replication regulator SLD3 CRC_subunit PF08624.10 EEA20545.1 - 2.7e-52 176.8 1.0 3.5e-52 176.4 0.1 1.6 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit AT_hook PF02178.19 EEA20545.1 - 5.3 7.3 8.9 19 5.6 8.9 2.0 1 0 0 1 1 1 0 AT hook motif MFS_1 PF07690.16 EEA20546.1 - 1.9e-40 138.9 28.2 1.9e-40 138.9 28.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA20546.1 - 1.3e-06 27.2 2.6 1.9e-06 26.6 2.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Homeodomain PF00046.29 EEA20547.1 - 1.7e-16 59.8 2.4 5.5e-16 58.2 2.4 1.9 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EEA20547.1 - 2.6e-05 24.0 0.8 6.9e-05 22.7 0.8 1.7 1 0 0 1 1 1 1 Homeobox KN domain DUF4638 PF15472.6 EEA20547.1 - 0.1 12.3 4.7 0.18 11.5 4.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) HAD_2 PF13419.6 EEA20548.1 - 2.6e-22 79.8 0.0 3.3e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA20548.1 - 5.4e-10 39.9 0.2 3.7e-05 24.1 0.0 2.9 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA20548.1 - 3e-07 31.0 0.0 4.1e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EEA20548.1 - 0.0044 17.1 0.2 0.07 13.3 0.2 2.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase GN3L_Grn1 PF08701.11 EEA20549.1 - 1e-23 83.2 20.1 1e-23 83.2 20.1 1.9 2 0 0 2 2 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EEA20549.1 - 1.3e-18 67.1 0.3 1.1e-13 51.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA20549.1 - 3.5e-07 30.3 0.0 2.8e-06 27.3 0.0 2.1 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EEA20549.1 - 1.8e-05 24.3 0.0 0.0002 20.9 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA20549.1 - 7.8e-05 22.8 4.9 0.43 10.6 0.1 3.9 2 2 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EEA20549.1 - 0.00019 21.0 1.2 0.47 10.0 0.0 3.1 3 1 0 3 3 3 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EEA20549.1 - 0.0036 16.7 0.0 0.16 11.3 0.0 2.3 2 0 0 2 2 2 1 AIG1 family MeaB PF03308.16 EEA20549.1 - 0.011 14.8 1.6 0.011 14.7 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Nuc_deoxyri_tr2 PF15891.5 EEA20549.1 - 0.039 14.3 1.3 11 6.4 0.6 2.4 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like AAA_18 PF13238.6 EEA20549.1 - 0.052 14.1 0.0 0.052 14.1 0.0 2.7 2 1 1 3 3 3 0 AAA domain Roc PF08477.13 EEA20549.1 - 0.094 12.9 0.0 22 5.3 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF2574 PF10836.8 EEA20549.1 - 0.2 11.5 0.0 0.68 9.8 0.0 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2574) NOG1 PF06858.14 EEA20549.1 - 0.22 11.3 0.9 4.2 7.2 0.0 2.8 2 1 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) AAA_16 PF13191.6 EEA20549.1 - 0.83 10.0 0.0 0.83 10.0 0.0 3.1 2 1 0 2 2 1 0 AAA ATPase domain CBFD_NFYB_HMF PF00808.23 EEA20550.1 - 1e-06 28.9 0.0 2.2e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA20550.1 - 0.0017 18.7 0.1 0.0017 18.7 0.1 2.8 2 1 1 3 3 3 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.13 EEA20550.1 - 2.9 7.8 24.8 4.3 7.2 24.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VIR_N PF15912.5 EEA20550.1 - 4.4 6.8 20.2 0.74 9.4 16.3 1.7 2 0 0 2 2 2 0 Virilizer, N-terminal SRP-alpha_N PF04086.13 EEA20550.1 - 6.7 6.6 21.5 0.74 9.7 16.9 1.6 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Adeno_terminal PF02459.15 EEA20550.1 - 7.8 4.8 11.9 14 3.9 11.9 1.4 1 1 0 1 1 1 0 Adenoviral DNA terminal protein SIR2 PF02146.17 EEA20551.1 - 6.4e-30 104.4 0.0 3e-29 102.2 0.0 1.9 1 1 0 1 1 1 1 Sir2 family ACP_PD PF04336.12 EEA20551.1 - 0.018 15.4 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase Med16 PF11635.8 EEA20552.1 - 6.6e-180 599.7 0.0 7.6e-180 599.5 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 EEA20552.1 - 0.042 14.1 0.0 0.68 10.3 0.0 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L29 PF00831.23 EEA20553.1 - 5.9e-18 64.6 0.7 5.9e-18 64.6 0.7 2.1 2 0 0 2 2 2 1 Ribosomal L29 protein CorA PF01544.18 EEA20553.1 - 0.059 12.7 2.4 0.077 12.3 2.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Cortex-I_coil PF09304.10 EEA20553.1 - 0.46 10.7 5.9 0.21 11.8 3.0 1.7 1 1 0 2 2 2 0 Cortexillin I, coiled coil V-SNARE_C PF12352.8 EEA20554.1 - 2.8e-14 53.1 0.1 2.8e-14 53.1 0.1 2.8 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus GOLGA2L5 PF15070.6 EEA20554.1 - 0.0028 16.4 7.7 0.0041 15.9 7.7 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 Dor1 PF04124.12 EEA20554.1 - 0.05 12.3 7.1 0.079 11.6 7.1 1.3 1 0 0 1 1 1 0 Dor1-like family STAT_alpha PF01017.20 EEA20554.1 - 0.092 12.6 3.9 0.62 9.9 3.9 2.2 2 1 0 2 2 2 0 STAT protein, all-alpha domain Not3 PF04065.15 EEA20554.1 - 0.15 11.5 3.1 0.24 10.8 1.4 1.7 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Syntaxin-6_N PF09177.11 EEA20554.1 - 0.34 11.5 5.9 1 10.0 5.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Sec34 PF04136.15 EEA20554.1 - 0.63 9.9 5.5 1.6 8.6 3.0 2.3 2 1 0 2 2 2 0 Sec34-like family Snapin_Pallidin PF14712.6 EEA20554.1 - 0.92 10.0 9.1 0.36 11.3 6.0 1.9 2 0 0 2 2 2 0 Snapin/Pallidin FapA PF03961.13 EEA20554.1 - 2.5 6.6 4.0 3.4 6.2 1.4 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A CENP-H PF05837.12 EEA20554.1 - 4.4 7.8 7.9 4 7.9 6.2 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) FUSC PF04632.12 EEA20554.1 - 5.4 5.4 6.6 8.4 4.8 6.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6_N PF17675.1 EEA20554.1 - 5.7 7.5 11.2 9.9 6.7 9.7 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region ATP-synt_10 PF05176.14 EEA20555.1 - 1e-83 280.5 0.0 1.3e-83 280.2 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein DNA_pol_B_palm PF14792.6 EEA20556.1 - 3.6e-35 120.6 0.0 7.1e-35 119.7 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EEA20556.1 - 7.9e-24 83.6 0.1 2.1e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase beta thumb HHH_8 PF14716.6 EEA20556.1 - 4.9e-20 71.7 1.6 1e-19 70.6 1.6 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 EEA20556.1 - 5.1e-19 67.8 0.3 1.8e-18 66.1 0.2 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda BRCT PF00533.26 EEA20556.1 - 1e-06 29.0 0.0 2.4e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EEA20556.1 - 0.00045 20.6 0.1 0.0018 18.6 0.0 2.1 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain NTP_transf_2 PF01909.23 EEA20556.1 - 0.0059 16.9 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain PTCB-BRCT PF12738.7 EEA20556.1 - 0.088 12.8 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain Zn_clus PF00172.18 EEA20559.1 - 0.0075 16.4 7.2 0.019 15.1 7.2 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-BED PF02892.15 EEA20559.1 - 0.011 15.7 0.2 0.026 14.5 0.2 1.6 1 0 0 1 1 1 0 BED zinc finger HbrB PF08539.11 EEA20559.1 - 0.04 13.9 0.8 0.1 12.6 0.2 1.9 2 0 0 2 2 2 0 HbrB-like CPL PF08144.11 EEA20561.1 - 4.5e-30 104.9 0.0 1.6e-28 99.9 0.0 3.3 4 0 0 4 4 4 1 CPL (NUC119) domain DNA_pol_phi PF04931.13 EEA20561.1 - 0.29 9.2 20.1 0.84 7.7 20.1 1.9 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EEA20561.1 - 0.88 7.8 18.9 1.4 7.2 18.9 1.3 1 0 0 1 1 1 0 CDC45-like protein VIR_N PF15912.5 EEA20561.1 - 1.1 8.8 9.6 60 3.1 0.0 2.4 2 0 0 2 2 2 0 Virilizer, N-terminal Nop14 PF04147.12 EEA20561.1 - 1.3 7.1 29.3 1.8 6.6 29.3 1.2 1 0 0 1 1 1 0 Nop14-like family BSP_II PF05432.11 EEA20561.1 - 1.5 8.4 24.6 2.8 7.5 24.6 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Presenilin PF01080.17 EEA20561.1 - 4.1 6.1 11.9 6.3 5.5 11.9 1.3 1 0 0 1 1 1 0 Presenilin DUF4090 PF13319.6 EEA20563.1 - 0.2 11.9 0.0 0.69 10.2 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4090) Rad51 PF08423.11 EEA20564.1 - 2.6e-129 429.9 0.0 3.2e-129 429.7 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EEA20564.1 - 1.9e-10 40.6 0.0 2.8e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EEA20564.1 - 2.1e-09 37.2 0.0 2.9e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 EEA20564.1 - 3.6e-06 27.5 0.9 1e-05 26.0 0.4 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 EEA20564.1 - 2.6e-05 23.7 0.6 0.00011 21.6 0.6 2.0 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EEA20564.1 - 0.0017 17.7 0.2 0.02 14.3 0.0 2.1 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EEA20564.1 - 0.023 15.0 0.3 0.099 12.9 0.3 2.0 1 1 0 1 1 1 0 AAA domain PAXNEB PF05625.11 EEA20564.1 - 0.038 13.1 0.4 0.33 10.1 0.1 2.0 2 0 0 2 2 2 0 PAXNEB protein Nup160 PF11715.8 EEA20565.1 - 1.2e-149 499.5 2.9 1.6e-149 499.0 2.9 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 MFS_1 PF07690.16 EEA20566.1 - 2.3e-33 115.6 50.6 2.9e-30 105.4 33.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM43 PF07787.12 EEA20566.1 - 0.078 12.3 2.3 0.21 10.9 2.3 1.8 1 0 0 1 1 1 0 Transmembrane protein 43 DUF2583 PF10762.9 EEA20566.1 - 0.1 13.0 4.3 0.23 11.9 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) DUF3808 PF10300.9 EEA20567.1 - 6.9e-141 470.2 0.0 8.5e-141 469.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) DSS1_SEM1 PF05160.13 EEA20568.1 - 3e-23 81.6 17.3 3.9e-23 81.3 17.3 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family PGK PF00162.19 EEA20569.1 - 5.4e-150 499.5 0.2 6.1e-150 499.4 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 EEA20569.1 - 0.063 13.3 1.0 0.26 11.3 0.0 2.5 3 0 0 3 3 3 0 PA domain DUF3530 PF12048.8 EEA20569.1 - 0.19 11.1 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Mpv17_PMP22 PF04117.12 EEA20570.1 - 1.2e-19 70.2 0.2 1.2e-19 70.2 0.2 2.0 2 0 0 2 2 2 1 Mpv17 / PMP22 family Trs65 PF12735.7 EEA20571.1 - 3.5e-97 325.6 0.0 4.6e-97 325.2 0.0 1.1 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 FF PF01846.19 EEA20572.1 - 1.6e-51 172.3 18.2 1.5e-13 50.7 0.3 7.0 6 1 0 6 6 6 5 FF domain WW PF00397.26 EEA20572.1 - 9e-19 67.3 14.4 3.1e-10 40.0 0.9 2.9 2 0 0 2 2 2 2 WW domain Glyco_hyd_101C PF17451.2 EEA20572.1 - 0.022 15.0 6.2 0.54 10.6 2.1 2.7 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain ABC_tran PF00005.27 EEA20573.1 - 4.4e-37 127.7 0.0 4.6e-17 62.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 EEA20573.1 - 3e-14 52.6 5.5 3e-14 52.6 5.5 2.1 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 EEA20573.1 - 9.1e-14 52.0 5.5 0.0062 16.4 0.0 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA20573.1 - 1.1e-12 47.8 2.1 0.00071 19.1 0.1 4.0 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA20573.1 - 1.7e-06 28.5 0.0 0.009 16.4 0.0 2.5 2 1 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 EEA20573.1 - 3.7e-06 27.4 0.0 0.017 15.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA20573.1 - 5.5e-06 26.7 0.0 0.0041 17.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EEA20573.1 - 1e-05 25.4 0.4 0.32 10.7 0.1 3.1 2 1 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 EEA20573.1 - 2.5e-05 24.8 0.0 0.56 10.8 0.0 3.5 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EEA20573.1 - 4e-05 23.3 0.5 0.12 12.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4 PF00037.27 EEA20573.1 - 7.3e-05 22.4 2.5 7.3e-05 22.4 2.5 2.7 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_24 PF13479.6 EEA20573.1 - 0.00026 20.8 0.2 0.045 13.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EEA20573.1 - 0.00027 20.9 0.1 0.27 11.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 EEA20573.1 - 0.0004 20.7 0.6 0.51 10.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EEA20573.1 - 0.00042 20.3 0.0 0.077 12.9 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_30 PF13604.6 EEA20573.1 - 0.00077 19.2 0.8 1.4 8.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EEA20573.1 - 0.00078 20.0 1.7 0.38 11.2 0.3 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA20573.1 - 0.00086 19.5 0.3 1 9.5 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_13 PF13166.6 EEA20573.1 - 0.00096 17.9 0.6 0.0065 15.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA20573.1 - 0.0014 19.0 0.7 0.92 9.9 0.0 2.9 3 0 0 3 3 2 1 RNA helicase Fer4_21 PF14697.6 EEA20573.1 - 0.0022 18.1 11.3 0.0045 17.1 11.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_7 PF12775.7 EEA20573.1 - 0.0022 17.5 0.1 0.27 10.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region TsaE PF02367.17 EEA20573.1 - 0.0026 17.8 0.2 0.038 14.0 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_6 PF12837.7 EEA20573.1 - 0.0034 17.4 12.3 0.0077 16.3 2.2 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain NB-ARC PF00931.22 EEA20573.1 - 0.0078 15.4 0.0 2.1 7.5 0.0 2.6 3 0 0 3 3 2 1 NB-ARC domain AAA_5 PF07728.14 EEA20573.1 - 0.011 15.7 1.4 2.1 8.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EEA20573.1 - 0.014 15.3 2.1 0.68 9.8 0.1 2.8 3 0 0 3 3 3 0 NACHT domain AAA_14 PF13173.6 EEA20573.1 - 0.017 15.1 0.4 3.1 7.8 0.1 3.3 3 1 0 3 3 2 0 AAA domain VirE PF05272.11 EEA20573.1 - 0.018 14.8 0.0 4.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E AAA_25 PF13481.6 EEA20573.1 - 0.019 14.6 0.5 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_10 PF13237.6 EEA20573.1 - 0.021 14.9 15.6 0.022 14.9 1.6 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain SRP54 PF00448.22 EEA20573.1 - 0.026 14.2 3.6 0.44 10.1 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Thymidylate_kin PF02223.17 EEA20573.1 - 0.029 14.0 0.7 6.5 6.4 0.0 2.8 3 0 0 3 3 2 0 Thymidylate kinase DUF815 PF05673.13 EEA20573.1 - 0.036 13.2 0.1 7.5 5.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.23 EEA20573.1 - 0.051 13.7 0.7 14 5.8 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase DLIC PF05783.11 EEA20573.1 - 0.058 12.2 0.4 0.1 11.4 0.0 1.5 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) PduV-EutP PF10662.9 EEA20573.1 - 0.059 13.1 2.3 0.12 12.1 0.1 2.5 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation Fer4_9 PF13187.6 EEA20573.1 - 0.071 13.3 11.7 0.15 12.3 11.7 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 EEA20573.1 - 0.078 13.9 0.3 0.078 13.9 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain ATPase PF06745.13 EEA20573.1 - 0.09 12.1 1.6 0.15 11.4 0.1 1.9 2 0 0 2 2 2 0 KaiC KAP_NTPase PF07693.14 EEA20573.1 - 0.11 11.8 0.0 7.2 5.7 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain MukB PF04310.12 EEA20573.1 - 0.12 12.1 0.7 13 5.5 0.0 2.8 3 0 0 3 3 3 0 MukB N-terminal Fer4_8 PF13183.6 EEA20573.1 - 0.28 11.7 6.7 0.29 11.6 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain CLP1_P PF16575.5 EEA20573.1 - 0.38 10.5 1.5 5 6.9 0.1 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Fer4_7 PF12838.7 EEA20573.1 - 0.6 10.8 12.7 0.069 13.7 1.6 2.2 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 EEA20573.1 - 1.8 8.8 9.9 0.25 11.5 1.2 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain NTPase_1 PF03266.15 EEA20573.1 - 2 8.3 3.6 11 6.0 0.2 2.8 3 0 0 3 3 3 0 NTPase Fer4_17 PF13534.6 EEA20573.1 - 5.8 7.5 10.4 0.21 12.2 0.8 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain SNF2_N PF00176.23 EEA20574.1 - 1.7e-55 188.2 0.0 2.6e-55 187.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 EEA20574.1 - 7.8e-21 73.7 2.2 7.5e-13 48.2 0.4 3.2 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EEA20574.1 - 2.1e-20 73.1 0.0 5.1e-20 71.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 EEA20574.1 - 4.7e-10 39.8 0.0 4.7e-10 39.8 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) HDA2-3 PF11496.8 EEA20574.1 - 4.8e-08 32.5 0.0 1.2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EEA20574.1 - 2.4e-07 30.9 0.0 7.9e-05 22.7 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 EEA20574.1 - 6.3e-06 26.5 17.4 6.7e-05 23.2 0.8 4.4 3 1 1 4 4 4 2 Chromodomain helicase DNA-binding domain 1 CHDCT2 PF08074.11 EEA20574.1 - 0.016 15.4 0.2 0.075 13.2 0.0 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain zf-H2C2_2 PF13465.6 EEA20575.1 - 1.4e-07 31.6 7.8 2.3e-06 27.8 0.6 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EEA20575.1 - 6e-07 29.3 1.5 0.01 15.8 0.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA20575.1 - 7.1e-06 26.2 0.3 7.1e-06 26.2 0.3 3.7 3 1 0 3 3 3 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 EEA20575.1 - 7.6e-06 26.5 5.3 0.16 12.6 0.0 3.3 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EEA20575.1 - 0.00055 20.5 7.5 0.0049 17.6 0.2 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EEA20575.1 - 0.19 11.5 0.8 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EEA20575.1 - 0.45 10.9 2.3 2.6 8.5 0.2 2.8 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zap1_zf2 PF18217.1 EEA20575.1 - 0.49 10.4 12.5 3.5 7.7 4.3 2.8 2 1 0 2 2 2 0 Zap1 zinc finger 2 FMO-like PF00743.19 EEA20576.1 - 1.5e-62 211.8 0.0 3e-62 210.8 0.0 1.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA20576.1 - 1.7e-12 47.2 0.0 1.8e-10 40.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA20576.1 - 6e-11 42.1 0.8 3.5e-07 29.7 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EEA20576.1 - 8.7e-08 32.3 0.0 2.2e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA20576.1 - 1.3e-07 31.1 0.0 4.6e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA20576.1 - 9e-06 25.8 0.0 0.0006 19.8 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 EEA20576.1 - 8.9e-05 22.9 0.0 0.21 12.1 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding Shikimate_DH PF01488.20 EEA20576.1 - 0.00018 21.6 0.1 1.9 8.6 0.0 3.1 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EEA20576.1 - 0.0002 20.8 0.0 0.05 13.0 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EEA20576.1 - 0.00021 21.8 0.1 0.02 15.4 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA20576.1 - 0.00029 20.2 0.6 0.00075 18.8 0.0 1.9 3 0 0 3 3 3 1 Thi4 family IlvN PF07991.12 EEA20576.1 - 0.00071 19.2 0.0 0.029 14.0 0.0 2.9 3 0 0 3 3 3 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Glu_dehyd_C PF16912.5 EEA20576.1 - 0.0022 17.5 0.2 0.013 15.0 0.0 2.2 3 0 0 3 3 3 1 Glucose dehydrogenase C-terminus DAO PF01266.24 EEA20576.1 - 0.0037 16.9 0.0 0.064 12.8 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EEA20576.1 - 0.0044 16.3 0.0 0.19 11.0 0.0 2.4 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_2 PF03446.15 EEA20576.1 - 0.011 15.9 0.0 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 EEA20576.1 - 0.016 15.2 0.1 0.035 14.1 0.1 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_2 PF00890.24 EEA20576.1 - 0.025 13.7 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_binding_3 PF01494.19 EEA20576.1 - 0.026 13.8 0.0 0.091 12.0 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 EEA20576.1 - 0.026 13.8 0.0 0.055 12.8 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EEA20576.1 - 0.086 11.5 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Aldo_ket_red PF00248.21 EEA20577.1 - 1.4e-63 214.8 0.0 1.8e-63 214.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_60s PF00428.19 EEA20578.1 - 0.29 11.7 0.2 0.29 11.7 0.2 3.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein TLP-20 PF06088.11 EEA20578.1 - 0.54 10.1 12.0 2.4 8.0 1.4 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) FAM176 PF14851.6 EEA20578.1 - 1 9.1 15.2 0.76 9.4 1.1 2.4 2 0 0 2 2 2 0 FAM176 family Nop14 PF04147.12 EEA20578.1 - 2.2 6.4 23.0 0.35 9.0 9.1 2.1 2 0 0 2 2 2 0 Nop14-like family Cwf_Cwc_15 PF04889.12 EEA20578.1 - 3.8 7.2 27.5 0.2 11.4 7.8 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 EEA20578.1 - 5.5 7.0 16.9 3.2 7.7 2.2 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal WRNPLPNID PF15017.6 EEA20578.1 - 9.8 7.1 20.2 6.7 7.7 7.9 2.7 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box AdoHcyase PF05221.17 EEA20579.1 - 1.7e-128 428.0 0.0 9.9e-74 248.2 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EEA20579.1 - 1.4e-82 275.5 3.2 2.3e-82 274.8 3.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EEA20579.1 - 4.9e-07 29.3 0.1 1e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EEA20579.1 - 0.0023 17.5 0.2 0.0045 16.6 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ELFV_dehydrog PF00208.21 EEA20579.1 - 0.01 15.6 0.1 0.017 14.8 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 EEA20579.1 - 0.014 15.6 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 EEA20579.1 - 0.034 14.0 0.8 0.061 13.2 0.8 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EEA20579.1 - 0.14 12.6 0.3 0.44 11.0 0.3 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding Nop PF01798.18 EEA20581.1 - 8.7e-62 208.6 0.0 1.2e-61 208.1 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EEA20581.1 - 2.1e-47 161.0 1.0 4.9e-47 159.8 1.0 1.7 1 0 0 1 1 1 1 Prp31 C terminal domain HAT PF02184.16 EEA20582.1 - 4.4e-25 87.3 77.5 3.7e-14 52.4 4.9 14.1 15 0 0 15 15 15 6 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 EEA20582.1 - 3.2e-21 74.2 22.9 0.0029 18.3 0.2 11.3 7 4 5 12 12 11 7 Tetratricopeptide repeat TPR_19 PF14559.6 EEA20582.1 - 1.3e-18 67.2 0.0 2.5e-05 24.7 0.0 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat Suf PF05843.14 EEA20582.1 - 1.9e-15 57.6 26.4 5e-05 23.4 1.2 7.2 2 1 4 7 7 7 4 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EEA20582.1 - 1.6e-08 34.3 5.2 0.06 13.8 0.0 7.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA20582.1 - 2.9e-08 33.3 6.2 15 6.1 0.0 8.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA20582.1 - 0.00073 20.0 18.4 21 6.0 0.0 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA20582.1 - 0.011 15.8 16.8 1.1 9.5 0.0 7.9 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA20582.1 - 0.022 15.4 8.3 13 6.5 0.1 6.8 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA20582.1 - 0.068 13.5 17.5 6.6 7.1 0.0 7.5 7 1 1 8 8 8 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EEA20582.1 - 0.38 10.8 27.4 0.055 13.5 2.1 6.8 5 2 3 8 8 7 0 U3 small nucleolar RNA-associated protein 6 ANAPC3 PF12895.7 EEA20582.1 - 0.41 10.9 3.0 12 6.3 0.0 4.3 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 PTS_IIA PF02255.16 EEA20582.1 - 0.5 10.4 2.2 34 4.6 0.4 3.3 3 0 0 3 3 3 0 PTS system, Lactose/Cellobiose specific IIA subunit NRDE-2 PF08424.10 EEA20582.1 - 0.66 9.0 29.9 1.9 7.5 4.4 6.1 2 2 3 5 5 5 0 NRDE-2, necessary for RNA interference Fis1_TPR_C PF14853.6 EEA20582.1 - 8.9 6.5 8.2 20 5.4 0.1 4.9 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat Kelch_6 PF13964.6 EEA20583.1 - 4.4e-06 26.8 9.1 0.004 17.4 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EEA20583.1 - 0.015 15.3 12.4 0.32 11.0 0.2 4.2 5 0 0 5 5 5 0 Galactose oxidase, central domain Rax2 PF12768.7 EEA20583.1 - 0.33 10.4 7.0 0.057 12.9 0.6 2.6 2 1 0 3 3 3 0 Cortical protein marker for cell polarity Kelch_1 PF01344.25 EEA20583.1 - 0.74 9.4 4.3 14 5.4 0.1 3.7 3 1 0 3 3 3 0 Kelch motif adh_short PF00106.25 EEA20584.1 - 1.6e-29 102.8 0.0 3e-21 75.8 0.0 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA20584.1 - 3.8e-20 72.4 0.0 2.9e-13 49.9 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA20584.1 - 9.5e-05 22.4 0.0 0.00015 21.7 0.0 1.2 1 0 0 1 1 1 1 KR domain SRR1 PF07985.12 EEA20585.1 - 2.1e-05 24.5 0.0 5.3e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 SRR1 zf-C2H2 PF00096.26 EEA20586.1 - 8.3e-07 29.1 11.7 6.3e-05 23.2 4.0 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA20586.1 - 1.9e-06 28.0 17.2 7e-06 26.2 2.8 3.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 EEA20586.1 - 0.00028 20.8 0.8 0.00028 20.8 0.8 2.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 EEA20586.1 - 0.00066 20.0 8.9 0.0024 18.2 0.6 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EEA20586.1 - 0.001 19.7 2.1 0.001 19.7 2.1 3.3 3 0 0 3 3 3 1 C2H2-type zinc finger DUF2225 PF09986.9 EEA20586.1 - 0.0068 16.1 0.3 0.013 15.2 0.3 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) zf-Di19 PF05605.12 EEA20586.1 - 0.01 16.1 4.8 0.01 16.1 4.8 1.8 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding MCPVI PF02993.14 EEA20586.1 - 8.9 6.1 7.0 21 4.9 6.9 1.7 1 1 0 1 1 1 0 Minor capsid protein VI UPF0261 PF06792.11 EEA20587.1 - 1.4e-166 554.5 1.2 1.6e-166 554.3 1.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) PEP_hydrolase PF09370.10 EEA20588.1 - 2.5e-134 446.6 0.3 2.9e-134 446.4 0.3 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 EEA20588.1 - 0.017 14.5 0.1 0.024 14.0 0.1 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DinI PF06183.13 EEA20590.1 - 0.11 12.8 0.2 3 8.2 0.0 2.9 2 1 1 3 3 3 0 DinI-like family ADH_N PF08240.12 EEA20591.1 - 6.4e-17 61.4 0.4 1.6e-16 60.1 0.4 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA20591.1 - 2.3e-12 47.0 0.0 3.6e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_11 PF08241.12 EEA20591.1 - 0.064 13.9 0.1 0.24 12.1 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain adh_short_C2 PF13561.6 EEA20592.1 - 6.3e-43 147.0 0.0 4.9e-37 127.7 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA20592.1 - 7.6e-41 139.7 0.0 1e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA20592.1 - 1.7e-14 54.2 0.0 2.8e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA20592.1 - 6.5e-06 25.8 0.1 0.00014 21.4 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA20592.1 - 0.0015 18.0 0.0 0.022 14.1 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Gag_p17 PF00540.18 EEA20592.1 - 0.07 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) WLM PF08325.10 EEA20593.1 - 0.0017 18.4 0.3 0.0017 18.4 0.3 1.8 2 0 0 2 2 2 1 WLM domain SVIP PF15811.5 EEA20593.1 - 1.4 9.4 12.3 2.7 8.5 11.7 1.8 1 1 0 1 1 1 0 Small VCP/p97-interacting protein zf-C2H2 PF00096.26 EEA20594.1 - 8.3e-16 57.5 56.2 7.9e-06 26.1 1.7 7.5 7 0 0 7 7 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA20594.1 - 5.7e-13 48.7 14.1 1.5e-08 34.6 1.4 7.0 7 0 0 7 7 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA20594.1 - 3.2e-12 46.2 48.3 0.00025 21.6 1.4 7.6 7 0 0 7 7 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA20594.1 - 4.4e-08 33.2 11.9 0.005 17.1 0.1 5.1 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EEA20594.1 - 2.5e-06 27.3 20.8 0.002 18.1 0.4 5.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 EEA20594.1 - 3.3e-05 24.1 17.2 0.0084 16.5 0.1 5.2 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EEA20594.1 - 8.6e-05 22.2 10.9 1.7 8.5 0.1 4.8 4 0 0 4 4 4 3 zinc-finger C2H2-type FOXP-CC PF16159.5 EEA20594.1 - 0.00031 21.3 0.2 0.00031 21.3 0.2 6.4 4 1 2 6 6 6 2 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 EEA20594.1 - 0.0046 16.7 33.9 0.025 14.3 0.5 6.6 6 1 0 6 6 6 2 C2H2-type zinc-finger domain XPA_N PF01286.18 EEA20594.1 - 0.019 15.0 4.1 0.86 9.7 0.4 3.1 2 0 0 2 2 2 0 XPA protein N-terminal Cript PF10235.9 EEA20594.1 - 0.43 11.2 9.6 0.53 10.9 0.1 3.6 3 0 0 3 3 3 0 Microtubule-associated protein CRIPT DEAD PF00270.29 EEA20595.1 - 2.3e-49 167.5 0.0 7e-49 166.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA20595.1 - 2.1e-27 95.7 0.0 1.2e-26 93.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA20595.1 - 0.0026 17.8 0.0 0.008 16.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Alpha-L-AF_C PF06964.12 EEA20596.1 - 4.6e-28 98.4 0.0 6.7e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Sugar_tr PF00083.24 EEA20597.1 - 1e-90 304.8 15.9 1.3e-90 304.5 15.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA20597.1 - 1e-21 77.2 31.6 1.8e-15 56.7 11.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MatC_N PF07158.11 EEA20597.1 - 0.051 13.6 1.9 0.13 12.3 1.9 1.7 1 0 0 1 1 1 0 Dicarboxylate carrier protein MatC N-terminus Nefa_Nip30_N PF10187.9 EEA20598.1 - 1.3e-33 115.5 10.7 3.1e-33 114.3 10.7 1.7 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Seryl_tRNA_N PF02403.22 EEA20598.1 - 0.26 11.5 8.6 0.12 12.6 5.0 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Aldo_ket_red PF00248.21 EEA20599.1 - 1.6e-45 155.5 0.0 1e-43 149.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family CK_II_beta PF01214.18 EEA20601.1 - 5.7e-79 264.2 0.2 7.2e-79 263.8 0.2 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Uso1_p115_C PF04871.13 EEA20601.1 - 0.094 13.1 3.6 0.18 12.2 3.6 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CxC5 PF18718.1 EEA20601.1 - 0.12 12.5 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases GCIP PF13324.6 EEA20601.1 - 1.7 8.1 3.5 3.5 7.2 3.5 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Abhydrolase_3 PF07859.13 EEA20602.1 - 5.5e-05 23.1 0.2 0.00025 21.0 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EEA20602.1 - 0.0096 15.6 0.0 0.026 14.2 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF3530 PF12048.8 EEA20602.1 - 0.034 13.6 0.0 0.048 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) JAB PF01398.21 EEA20603.1 - 7.4e-09 35.6 0.1 2e-07 31.0 0.1 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UCR_14kD PF02271.16 EEA20603.1 - 0.056 13.4 0.6 8.2 6.5 0.0 2.7 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.27 EEA20604.1 - 2.1e-44 149.4 2.8 8.5e-18 64.1 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein PPDFL PF15060.6 EEA20604.1 - 0.016 15.7 1.9 0.037 14.6 0.1 2.3 2 1 0 2 2 2 0 Differentiation and proliferation regulator Trypan_PARP PF05887.11 EEA20605.1 - 0.00067 19.7 86.3 0.002 18.1 19.2 26.4 16 8 10 26 26 26 7 Procyclic acidic repetitive protein (PARP) HMG_box PF00505.19 EEA20606.1 - 5.2e-10 39.6 0.1 5.2e-10 39.6 0.1 3.6 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA20606.1 - 1.8e-07 31.6 0.2 1.8e-07 31.6 0.2 3.5 3 1 0 3 3 3 1 HMG-box domain FliG_C PF01706.16 EEA20606.1 - 0.00064 19.9 0.2 0.0022 18.1 0.2 2.0 1 1 0 1 1 1 1 FliG C-terminal domain FAM199X PF15814.5 EEA20606.1 - 0.96 8.4 7.0 2 7.4 7.0 1.5 1 0 0 1 1 1 0 Protein family FAM199X DUF445 PF04286.12 EEA20606.1 - 5 6.8 10.5 5.5 6.7 8.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF445) HHV6-IE PF03753.13 EEA20606.1 - 7.4 3.9 8.0 10 3.4 8.0 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein Inhibitor_I78 PF11720.8 EEA20607.1 - 4.9e-05 23.3 0.0 6.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 EEA20607.1 - 0.0022 18.6 0.0 0.0035 18.0 0.0 1.5 1 1 0 1 1 1 1 Potato inhibitor I family Tmemb_9 PF05434.11 EEA20609.1 - 0.00056 19.8 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 TMEM9 FAM176 PF14851.6 EEA20609.1 - 0.041 13.6 0.2 0.071 12.8 0.2 1.5 1 0 0 1 1 1 0 FAM176 family FAM163 PF15069.6 EEA20609.1 - 0.18 12.3 0.0 0.36 11.3 0.0 1.5 1 1 0 1 1 1 0 FAM163 family VPS9 PF02204.18 EEA20610.1 - 1.4e-17 63.8 0.0 3.3e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 EEA20610.1 - 1e-15 57.6 0.1 3.4e-14 52.7 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA20610.1 - 3.8e-11 43.4 0.4 0.0065 17.0 0.0 4.5 3 1 3 6 6 5 3 Ankyrin repeats (3 copies) PX PF00787.24 EEA20610.1 - 4.8e-07 29.7 0.0 2.1e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 PX domain Ank_4 PF13637.6 EEA20610.1 - 0.0001 22.7 0.0 1.5 9.5 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA20610.1 - 0.00027 21.2 0.7 2.6 8.6 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EEA20610.1 - 0.002 18.5 0.1 4.2 8.3 0.0 5.1 5 0 0 5 5 5 1 Ankyrin repeat SRP54 PF00448.22 EEA20610.1 - 0.0042 16.8 0.0 0.075 12.7 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain ThiJ_like PF17124.5 EEA20610.1 - 0.041 13.6 0.0 12 5.5 0.0 2.6 2 0 0 2 2 2 0 ThiJ/PfpI family-like BsuBI_PstI_RE_N PF17728.1 EEA20610.1 - 0.058 13.3 1.2 0.2 11.5 1.2 1.9 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease HTH domain Flavin_Reduct PF01613.18 EEA20610.1 - 0.27 11.3 2.1 0.38 10.8 0.5 2.0 2 0 0 2 2 2 0 Flavin reductase like domain Ribosomal_S11 PF00411.19 EEA20611.1 - 6.9e-09 36.1 0.1 1.7e-08 34.8 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S11 CTNNB1_binding PF08347.11 EEA20611.1 - 0.11 12.7 3.7 0.16 12.1 2.0 1.9 1 1 1 3 3 3 0 N-terminal CTNNB1 binding Tim44 PF04280.15 EEA20612.1 - 2.1e-34 118.7 0.0 5.6e-34 117.4 0.0 1.8 1 0 0 1 1 1 1 Tim44-like domain Med7 PF05983.11 EEA20612.1 - 0.14 12.2 4.5 0.33 11.0 4.5 1.6 1 0 0 1 1 1 0 MED7 protein SGTA_dimer PF16546.5 EEA20613.1 - 8.8e-24 83.1 0.1 1.4e-23 82.4 0.1 1.4 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 EEA20613.1 - 5.5e-16 57.6 6.7 1.8e-05 24.3 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA20613.1 - 3.1e-14 51.9 8.8 0.00022 21.1 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EEA20613.1 - 3.3e-11 42.7 10.4 2.4e-06 27.1 1.5 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 EEA20613.1 - 1e-09 37.8 6.0 0.0021 18.1 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA20613.1 - 1e-08 35.6 12.5 0.00029 21.4 4.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA20613.1 - 2.1e-07 30.8 2.3 0.0023 18.2 0.4 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA20613.1 - 9.1e-07 29.2 7.0 0.15 13.0 0.5 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 EEA20613.1 - 1.3e-06 28.0 0.6 0.34 11.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA20613.1 - 2.3e-06 27.8 7.3 0.0011 19.2 1.8 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EEA20613.1 - 1e-05 25.6 2.0 6.7e-05 23.0 1.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA20613.1 - 1.5e-05 25.4 3.8 0.0018 18.8 0.6 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat STI1 PF17830.1 EEA20613.1 - 5.6e-05 23.0 5.3 0.0026 17.6 2.9 2.4 2 0 0 2 2 2 1 STI1 domain TPR_10 PF13374.6 EEA20613.1 - 0.0031 17.3 10.2 0.14 12.0 0.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA20613.1 - 0.0042 17.6 3.7 0.28 11.9 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat XPC-binding PF09280.11 EEA20613.1 - 0.012 15.3 1.5 0.027 14.2 1.5 1.6 1 0 0 1 1 1 0 XPC-binding domain BTAD PF03704.17 EEA20613.1 - 0.022 15.2 1.1 0.022 15.2 1.1 1.9 2 0 0 2 2 2 0 Bacterial transcriptional activator domain MIT PF04212.18 EEA20613.1 - 0.082 13.0 0.7 3.7 7.7 0.1 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_4 PF07721.14 EEA20613.1 - 0.25 12.1 1.9 33 5.5 0.6 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat RIC1 PF07064.13 EEA20614.1 - 8.2e-85 284.2 0.1 1.2e-84 283.6 0.1 1.3 1 0 0 1 1 1 1 RIC1 AID PF18767.1 EEA20614.1 - 0.12 12.4 0.0 0.48 10.5 0.0 1.9 2 0 0 2 2 2 0 Activation induced deaminase Pre-PUA PF17832.1 EEA20615.1 - 3.4e-23 82.1 0.1 4.5e-23 81.7 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EEA20615.1 - 8.1e-14 51.3 0.3 1.1e-13 50.9 0.3 1.2 1 0 0 1 1 1 1 PUA domain Pre-PUA PF17832.1 EEA20616.1 - 3.4e-23 82.1 0.1 4.5e-23 81.7 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EEA20616.1 - 8.1e-14 51.3 0.3 1.1e-13 50.9 0.3 1.2 1 0 0 1 1 1 1 PUA domain Pre-PUA PF17832.1 EEA20617.1 - 3.4e-23 82.1 0.1 4.5e-23 81.7 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EEA20617.1 - 8.1e-14 51.3 0.3 1.1e-13 50.9 0.3 1.2 1 0 0 1 1 1 1 PUA domain PUA PF01472.20 EEA20618.1 - 4.6e-14 52.1 0.3 5.9e-14 51.8 0.3 1.2 1 0 0 1 1 1 1 PUA domain Pre-PUA PF17832.1 EEA20618.1 - 5.1e-08 33.5 0.3 7.2e-08 33.0 0.3 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain YchF-GTPase_C PF06071.13 EEA20619.1 - 5.7e-36 122.6 0.1 1.5e-35 121.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EEA20619.1 - 2e-16 60.1 0.0 5.5e-16 58.7 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EEA20619.1 - 0.00066 19.7 0.0 0.0018 18.3 0.0 1.8 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EEA20619.1 - 0.00094 18.7 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_23 PF13476.6 EEA20619.1 - 6.5 7.2 7.0 1.6e+02 2.6 7.0 2.4 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EEA20620.1 - 1.1e-18 67.9 0.7 5.3e-18 65.6 0.1 2.3 3 0 0 3 3 3 1 Dynamin family Dynamin_M PF01031.20 EEA20620.1 - 1.5e-12 47.4 0.4 4.6e-11 42.5 0.1 2.7 2 1 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EEA20620.1 - 1.6e-06 28.1 0.0 7.5e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA20620.1 - 0.00045 19.8 0.0 0.0036 16.8 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B CDT1_C PF16679.5 EEA20620.1 - 0.079 13.4 0.0 0.44 11.0 0.0 2.2 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Abhydrolase_1 PF00561.20 EEA20621.1 - 1.8e-14 54.0 0.2 2.7e-14 53.4 0.2 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA20621.1 - 3.4e-08 34.4 2.4 4.4e-08 34.0 2.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA20621.1 - 4.9e-05 22.7 0.0 6.4e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Tannase PF07519.11 EEA20622.1 - 3.9e-101 339.3 1.7 4.5e-101 339.1 1.7 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EEA20622.1 - 8.8e-08 31.9 0.0 0.00034 20.2 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA20622.1 - 0.0024 17.2 0.0 0.008 15.5 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA20622.1 - 0.015 14.9 0.2 0.14 11.8 0.1 2.4 2 0 0 2 2 2 0 alpha/beta hydrolase fold Zn_clus PF00172.18 EEA20623.1 - 8.3e-07 29.0 14.5 1.2e-06 28.5 14.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRAF_BIRC3_bd PF16673.5 EEA20623.1 - 0.017 14.9 0.8 0.037 13.8 0.8 1.6 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Mod_r PF07200.13 EEA20624.1 - 2e-24 86.4 2.8 2.6e-24 86.0 2.8 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein PspA_IM30 PF04012.12 EEA20624.1 - 0.14 11.7 5.5 0.21 11.1 5.5 1.3 1 1 0 1 1 1 0 PspA/IM30 family Nbl1_Borealin_N PF10444.9 EEA20624.1 - 0.24 11.0 1.2 6.3 6.5 0.1 2.4 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal Caskin-Pro-rich PF16907.5 EEA20624.1 - 0.29 11.7 4.5 0.72 10.4 4.5 1.7 1 0 0 1 1 1 0 Proline rich region of Caskin proteins Aldo_ket_red PF00248.21 EEA20625.1 - 2.7e-47 161.4 0.0 9.8e-47 159.6 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family GFA PF04828.14 EEA20626.1 - 9e-07 29.2 1.3 1.8e-06 28.2 1.1 1.7 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme PHD_Oberon PF07227.11 EEA20626.1 - 0.26 11.2 4.9 0.99 9.3 0.3 2.2 2 0 0 2 2 2 0 PHD - plant homeodomain finger protein CHCH PF06747.13 EEA20627.1 - 1.1e-05 25.4 0.6 1.8e-05 24.7 0.6 1.3 1 0 0 1 1 1 1 CHCH domain COX17 PF05051.13 EEA20627.1 - 0.0015 18.8 2.1 0.0066 16.8 0.3 2.1 1 1 1 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) Pet191_N PF10203.9 EEA20627.1 - 0.013 15.8 2.2 0.3 11.4 0.8 2.0 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 EEA20627.1 - 0.047 13.4 0.1 0.056 13.2 0.1 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) NPR3 PF03666.13 EEA20628.1 - 3.9e-156 520.5 0.0 6.1e-156 519.9 0.0 1.3 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Ribosomal_S30AE PF02482.19 EEA20628.1 - 0.069 13.9 2.1 7.1 7.5 0.9 2.5 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Pox_Ag35 PF03286.14 EEA20628.1 - 0.25 11.1 4.4 0.061 13.1 0.6 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein La PF05383.17 EEA20629.1 - 1.5e-18 66.6 0.1 2.6e-18 65.8 0.1 1.4 1 0 0 1 1 1 1 La domain La PF05383.17 EEA20630.1 - 1.5e-18 66.6 0.1 2.6e-18 65.8 0.1 1.4 1 0 0 1 1 1 1 La domain Band_7 PF01145.25 EEA20631.1 - 2.4e-30 105.9 0.7 5.4e-30 104.7 0.7 1.6 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EEA20631.1 - 4.4e-25 87.5 1.2 1.1e-24 86.2 1.2 1.8 1 0 0 1 1 1 1 C-terminal region of band_7 DRTGG PF07085.12 EEA20631.1 - 0.04 13.7 0.6 0.67 9.8 0.0 2.4 1 1 1 2 2 2 0 DRTGG domain Pox_A11 PF05061.13 EEA20631.1 - 0.073 12.3 0.3 0.11 11.7 0.3 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein Hira PF07569.11 EEA20632.1 - 1.4e-84 283.2 0.1 2.7e-84 282.3 0.1 1.5 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 EEA20632.1 - 3.1e-26 91.1 30.6 2.6e-05 24.9 0.0 8.9 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20632.1 - 1e-13 51.3 0.0 0.36 11.1 0.0 6.0 3 1 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EEA20632.1 - 9.7e-11 41.3 0.1 3.3e-10 39.6 0.1 2.0 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 EEA20632.1 - 8.5e-06 25.6 2.2 0.44 10.6 0.0 5.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EEA20632.1 - 3.3e-05 23.0 0.3 3.5 6.5 0.0 4.8 3 1 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EEA20632.1 - 0.16 10.0 0.0 0.32 8.9 0.0 1.5 1 0 0 1 1 1 0 IKI3 family MIP PF00230.20 EEA20633.1 - 0.0039 16.9 0.0 0.005 16.6 0.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein Methyltransf_31 PF13847.6 EEA20634.1 - 1.4e-15 57.4 0.0 3.8e-08 33.2 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EEA20634.1 - 3.7e-09 36.6 1.3 2.2e-08 34.1 1.3 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA20634.1 - 7e-07 29.9 0.0 9e-06 26.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA20634.1 - 7.8e-06 26.5 0.0 0.00082 20.0 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA20634.1 - 6.1e-05 23.7 2.3 0.0013 19.5 0.4 2.8 3 0 0 3 3 2 1 Methyltransferase domain SGT1 PF07093.11 EEA20634.1 - 0.00063 18.3 11.6 0.00085 17.9 11.6 1.1 1 0 0 1 1 1 1 SGT1 protein Methyltransf_32 PF13679.6 EEA20634.1 - 0.00072 19.6 1.8 0.001 19.1 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 EEA20634.1 - 0.0014 18.8 0.0 0.056 13.5 0.0 2.1 1 1 0 1 1 1 1 FtsJ-like methyltransferase RNA_pol_3_Rpc31 PF11705.8 EEA20634.1 - 0.0069 16.7 6.9 0.0069 16.7 6.9 2.3 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 EEA20634.1 - 0.013 14.8 14.5 0.013 14.8 14.5 2.1 2 0 0 2 2 2 0 NOA36 protein MTS PF05175.14 EEA20634.1 - 0.019 14.5 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain RXT2_N PF08595.11 EEA20634.1 - 0.027 14.5 16.3 0.53 10.3 6.3 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal MetW PF07021.12 EEA20634.1 - 0.028 14.0 0.2 0.056 13.0 0.1 1.5 2 0 0 2 2 1 0 Methionine biosynthesis protein MetW PrmA PF06325.13 EEA20634.1 - 0.042 13.2 0.0 0.12 11.7 0.0 1.8 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CENP-B_dimeris PF09026.10 EEA20634.1 - 0.043 14.2 37.5 0.062 13.7 2.0 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PCMT PF01135.19 EEA20634.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PTPRCAP PF15713.5 EEA20634.1 - 0.38 11.0 17.3 3.7 7.8 10.0 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 EEA20634.1 - 0.46 8.6 22.6 0.094 10.9 11.4 2.0 2 0 0 2 2 2 0 Nop14-like family Usp PF00582.26 EEA20634.1 - 0.74 10.3 3.6 0.37 11.3 0.9 1.8 2 0 0 2 2 2 0 Universal stress protein family WRNPLPNID PF15017.6 EEA20634.1 - 3.4 8.6 27.6 1.6 9.7 4.8 2.7 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Myc_N PF01056.18 EEA20634.1 - 6.1 6.6 21.2 0.39 10.6 8.8 2.2 2 0 0 2 2 2 0 Myc amino-terminal region TFB6 PF17110.5 EEA20634.1 - 7.9 6.2 13.5 1.6 8.5 4.8 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH FYDLN_acid PF09538.10 EEA20634.1 - 8.1 7.2 26.3 4.6 8.0 3.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 EEA20634.1 - 8.7 4.3 31.5 2.9 5.9 1.9 2.1 2 0 0 2 2 2 0 DNA polymerase phi Yippee-Mis18 PF03226.14 EEA20635.1 - 2.1e-17 63.2 0.1 2.3e-17 63.1 0.1 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HECT_2 PF09814.9 EEA20635.1 - 0.17 10.7 0.1 0.75 8.6 0.0 1.7 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Methyltransf_16 PF10294.9 EEA20636.1 - 6.5e-11 42.3 0.0 1e-10 41.7 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase GidB PF02527.15 EEA20636.1 - 0.024 13.9 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 EEA20636.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain zf-C2H2 PF00096.26 EEA20637.1 - 0.0053 17.2 3.4 0.016 15.7 3.4 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type PAP1 PF08601.10 EEA20637.1 - 0.0082 15.9 3.9 0.0082 15.9 3.9 2.8 1 1 2 3 3 3 1 Transcription factor PAP1 BING4CT PF08149.11 EEA20637.1 - 0.013 15.2 0.2 0.047 13.5 0.0 1.9 2 0 0 2 2 2 0 BING4CT (NUC141) domain zf-C2H2_4 PF13894.6 EEA20637.1 - 0.21 12.5 3.3 0.59 11.1 3.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1932 PF09130.11 EEA20638.1 - 0.062 13.3 0.6 0.17 11.9 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) BUD22 PF09073.10 EEA20638.1 - 0.26 10.6 11.9 0.32 10.3 11.9 1.4 1 1 0 1 1 1 0 BUD22 Ribosomal_L24e PF01246.20 EEA20639.1 - 3.5e-29 100.8 5.1 3.5e-29 100.8 5.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L24e Ribosomal_L24e PF01246.20 EEA20640.1 - 0.00015 21.9 0.9 0.00015 21.9 0.9 2.1 2 0 0 2 2 2 1 Ribosomal protein L24e MCU PF04678.13 EEA20640.1 - 0.25 11.4 1.3 0.33 11.0 1.3 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Pam16 PF03656.13 EEA20641.1 - 2.7e-07 30.6 0.0 3.9e-07 30.1 0.0 1.3 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 EEA20641.1 - 3.9e-05 23.7 0.1 6.5e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Fungal_trans PF04082.18 EEA20642.1 - 9.9e-24 83.8 0.0 2.6e-23 82.4 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20642.1 - 8.9e-10 38.5 13.1 1.5e-09 37.8 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M41 PF01434.18 EEA20643.1 - 6.5e-69 231.6 0.0 1.2e-68 230.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EEA20643.1 - 4.3e-43 146.9 0.0 1.3e-42 145.3 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA20643.1 - 1.1e-12 47.5 0.8 2.5e-12 46.4 0.2 1.9 2 0 0 2 2 2 1 AAA+ lid domain FtsH_ext PF06480.15 EEA20643.1 - 2.3e-08 34.3 0.1 6.9e-08 32.8 0.1 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 EEA20643.1 - 0.00054 20.0 0.0 0.0026 17.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA20643.1 - 0.001 19.4 0.4 0.12 12.7 0.1 3.5 2 1 1 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 EEA20643.1 - 0.0083 15.4 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EEA20643.1 - 0.0096 16.2 0.3 1.2 9.4 0.1 3.3 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 EEA20643.1 - 0.012 15.4 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain YqzH PF14164.6 EEA20643.1 - 0.014 15.5 0.1 4.1 7.6 0.0 2.9 2 0 0 2 2 2 0 YqzH-like protein AAA_2 PF07724.14 EEA20643.1 - 0.05 13.7 0.0 0.18 11.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EEA20643.1 - 0.059 13.1 0.1 0.24 11.1 0.1 2.0 2 1 0 2 2 2 0 IstB-like ATP binding protein AAA_17 PF13207.6 EEA20643.1 - 0.091 13.2 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF2508 PF10704.9 EEA20643.1 - 0.14 12.4 1.9 0.4 10.9 1.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) KH_1 PF00013.29 EEA20644.1 - 5.7e-41 138.2 10.1 2.9e-17 62.2 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EEA20644.1 - 1.1e-09 37.9 10.1 0.0073 16.1 1.2 3.5 3 1 0 3 3 3 3 KH domain KH_4 PF13083.6 EEA20644.1 - 3.8e-08 33.1 5.6 0.024 14.5 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EEA20644.1 - 0.00016 21.7 6.8 0.1 12.7 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain ADH_N PF08240.12 EEA20645.1 - 7e-29 99.9 1.6 1.1e-28 99.2 1.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA20645.1 - 1.7e-16 60.4 0.0 3.2e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA20645.1 - 3.4e-06 26.7 0.0 4.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 EEA20645.1 - 4.2e-05 23.4 0.4 9.4e-05 22.2 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N_2 PF13602.6 EEA20645.1 - 0.0026 18.8 0.0 0.0057 17.7 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EEA20645.1 - 0.1 11.9 0.0 0.3 10.3 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain RabGAP-TBC PF00566.18 EEA20647.1 - 2.2e-31 109.2 1.3 4.7e-31 108.1 1.3 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain POP1 PF06978.11 EEA20647.1 - 2.2 8.2 5.0 34 4.3 5.0 2.2 1 1 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 Pkinase PF00069.25 EEA20648.1 - 2.3e-56 191.1 0.0 3.4e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20648.1 - 3.3e-20 72.4 0.0 4.9e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA20648.1 - 1e-05 25.0 0.0 2.7e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EEA20648.1 - 0.0011 19.0 0.1 0.015 15.3 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA20648.1 - 0.0013 17.7 0.0 0.0022 17.0 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EEA20648.1 - 0.0049 16.5 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EEA20648.1 - 0.0049 15.7 0.0 0.0085 14.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase F-box-like PF12937.7 EEA20649.1 - 1.6e-12 47.1 0.0 4.5e-12 45.7 0.0 1.9 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EEA20649.1 - 3.4e-10 39.1 12.1 0.21 11.7 0.0 6.8 8 0 0 8 8 8 3 Leucine Rich repeat F-box PF00646.33 EEA20649.1 - 1.8e-09 37.3 0.0 7.8e-09 35.2 0.0 2.3 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EEA20649.1 - 2e-05 24.8 10.6 0.087 13.3 0.1 5.4 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) PRANC PF09372.10 EEA20649.1 - 0.00022 21.5 0.6 0.0014 18.9 0.0 2.3 2 0 0 2 2 2 1 PRANC domain LRR_1 PF00560.33 EEA20649.1 - 0.0063 16.9 6.7 21 6.2 0.1 5.7 5 1 0 5 5 5 2 Leucine Rich Repeat Phage_TTP_1 PF04630.12 EEA20649.1 - 0.05 12.9 0.0 0.093 12.0 0.0 1.3 1 0 0 1 1 1 0 Phage tail tube protein Efg1 PF10153.9 EEA20650.1 - 3.1e-32 111.3 13.2 3.1e-32 111.3 13.2 2.7 3 0 0 3 3 3 1 rRNA-processing protein Efg1 TMEM232 PF15877.5 EEA20650.1 - 0.066 12.2 0.4 0.12 11.4 0.4 1.4 1 0 0 1 1 1 0 Transmembrane protein family 232 DUF4349 PF14257.6 EEA20650.1 - 0.1 12.0 0.3 0.1 12.0 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) zinc_ribbon_16 PF17034.5 EEA20651.1 - 3e-17 63.0 16.4 2.4e-12 47.1 8.3 3.4 1 1 1 3 3 3 2 Zinc-ribbon like family zf-rbx1 PF12678.7 EEA20651.1 - 0.0022 18.2 0.4 0.0096 16.2 0.4 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EEA20651.1 - 0.0061 16.2 7.3 0.0061 16.2 7.3 2.9 4 0 0 4 4 4 1 Zinc-ribbon, C4HC2 type HrpB1_HrpK PF09613.10 EEA20651.1 - 0.017 14.7 0.4 0.035 13.8 0.4 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) WD40 PF00400.32 EEA20651.1 - 0.14 13.1 1.3 4 8.5 0.5 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat Ribosomal_L7Ae PF01248.26 EEA20652.1 - 4.2e-26 90.5 0.1 5.1e-26 90.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EEA20652.1 - 0.00092 19.3 0.0 0.00099 19.2 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 EEA20652.1 - 0.0017 18.2 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain Ku_PK_bind PF08785.11 EEA20653.1 - 1.1e-38 132.0 0.1 2.8e-38 130.8 0.1 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 EEA20653.1 - 1.3e-32 113.1 0.0 2.2e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EEA20653.1 - 5.6e-13 49.1 0.0 1.3e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EEA20653.1 - 0.0048 17.6 2.0 0.0076 16.9 0.5 2.2 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm VWA PF00092.28 EEA20653.1 - 0.011 16.0 0.1 0.029 14.6 0.1 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain Ku_PK_bind PF08785.11 EEA20654.1 - 6.3e-37 126.4 0.1 1.6e-36 125.0 0.1 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 EEA20654.1 - 1.4e-32 113.1 0.0 2.4e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EEA20654.1 - 5.8e-13 49.1 0.0 1.3e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EEA20654.1 - 0.0049 17.5 2.0 0.0076 16.9 0.5 2.2 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm VWA PF00092.28 EEA20654.1 - 0.011 16.0 0.1 0.029 14.6 0.1 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF4149 PF13664.6 EEA20655.1 - 2.3e-26 92.1 1.5 2.3e-26 92.1 1.5 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Sugar_tr PF00083.24 EEA20656.1 - 1.5e-90 304.3 27.9 1.8e-90 304.0 27.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA20656.1 - 1.6e-17 63.5 27.6 1.6e-17 63.5 27.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TrbC PF04956.13 EEA20656.1 - 0.076 13.2 5.3 4.7 7.5 0.0 3.8 4 2 1 5 5 5 0 TrbC/VIRB2 family DUF2663 PF10864.8 EEA20656.1 - 0.38 11.2 2.0 0.51 10.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) DUF1700 PF08006.11 EEA20656.1 - 1.3 8.6 3.8 2.4 7.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) DUF2427 PF10348.9 EEA20656.1 - 3.3 7.6 6.2 0.93 9.3 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) NPV_P10 PF05531.12 EEA20657.1 - 5.8e-07 29.9 50.4 0.0012 19.3 3.9 9.7 4 1 4 9 9 9 3 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 EEA20657.1 - 0.00037 18.2 34.3 0.00037 18.2 34.3 4.3 2 1 2 4 4 4 2 Protein of unknown function (DUF3584) DHR10 PF18595.1 EEA20657.1 - 0.0017 18.4 10.8 0.0017 18.4 10.8 7.3 4 2 2 7 7 7 2 Designed helical repeat protein 10 domain DUF1664 PF07889.12 EEA20657.1 - 0.013 15.5 53.2 0.067 13.2 8.1 7.7 1 1 4 7 7 7 0 Protein of unknown function (DUF1664) FUSC PF04632.12 EEA20657.1 - 0.46 8.9 6.6 4.5 5.7 3.0 2.5 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF948 PF06103.11 EEA20657.1 - 4.2 7.7 35.2 0.21 11.9 4.2 6.8 4 3 1 5 5 5 0 Bacterial protein of unknown function (DUF948) FAD_binding_3 PF01494.19 EEA20658.1 - 1.2e-88 297.7 0.0 2e-88 297.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EEA20658.1 - 5.3e-58 195.7 0.0 1e-57 194.8 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EEA20658.1 - 8.5e-05 21.9 0.0 0.00019 20.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA20658.1 - 0.00072 18.9 0.0 0.0037 16.5 0.0 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EEA20658.1 - 0.00092 18.4 0.0 0.0017 17.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EEA20658.1 - 0.00093 18.0 0.0 0.0014 17.5 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 EEA20658.1 - 0.0041 16.2 0.1 0.0076 15.3 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EEA20658.1 - 0.0047 17.1 0.0 0.016 15.4 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA20658.1 - 0.014 16.0 0.0 0.035 14.7 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EEA20658.1 - 0.019 14.0 0.0 0.2 10.7 0.0 2.1 1 1 0 1 1 1 0 Squalene epoxidase Pyr_redox_3 PF13738.6 EEA20658.1 - 0.04 13.2 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA20658.1 - 0.047 13.3 0.0 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA20658.1 - 0.094 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EEA20658.1 - 0.15 11.1 0.1 0.3 10.1 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EEA20658.1 - 0.19 12.2 0.0 0.53 10.7 0.0 1.7 2 0 0 2 2 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EEA20659.1 - 4.9e-89 299.0 0.0 7.8e-89 298.3 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA20659.1 - 5.7e-05 22.5 0.0 0.00013 21.3 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA20659.1 - 0.00053 19.3 0.0 0.0025 17.1 0.0 1.8 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EEA20659.1 - 0.00063 18.5 0.0 0.00095 18.0 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 EEA20659.1 - 0.00066 18.9 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EEA20659.1 - 0.0029 16.7 0.1 0.0051 15.9 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EEA20659.1 - 0.0042 17.3 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EEA20659.1 - 0.0083 15.2 0.0 0.45 9.5 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox PF00070.27 EEA20659.1 - 0.0099 16.4 0.0 0.024 15.2 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA20659.1 - 0.029 13.6 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA20659.1 - 0.046 13.3 0.1 0.074 12.6 0.1 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA20659.1 - 0.065 12.5 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EEA20659.1 - 0.11 12.9 0.0 0.34 11.4 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 EEA20659.1 - 0.12 11.7 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EEA20659.1 - 0.13 11.3 0.1 0.21 10.7 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A PX PF00787.24 EEA20660.1 - 8.7e-16 57.9 0.2 2.9e-15 56.2 0.1 1.8 2 0 0 2 2 2 1 PX domain PGAP1 PF07819.13 EEA20661.1 - 0.001 18.8 0.2 0.0042 16.8 0.0 2.1 2 1 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EEA20661.1 - 0.0026 18.4 0.1 0.0052 17.4 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family UPF0227 PF05728.12 EEA20661.1 - 0.01 15.8 1.0 0.027 14.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Abhydrolase_3 PF07859.13 EEA20661.1 - 0.037 13.9 0.0 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EEA20661.1 - 0.039 13.8 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.8 EEA20661.1 - 0.04 13.2 0.0 0.069 12.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Thioesterase PF00975.20 EEA20661.1 - 0.051 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain DUF676 PF05057.14 EEA20661.1 - 0.1 12.1 0.2 0.28 10.6 0.0 1.7 2 0 0 2 2 2 0 Putative serine esterase (DUF676) SIP1 PF04938.12 EEA20662.1 - 3.9e-11 43.1 0.0 2.7e-08 33.8 0.0 3.1 2 1 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) tRNA-synt_2 PF00152.20 EEA20663.1 - 1.1e-65 221.8 0.1 1.4e-65 221.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA20663.1 - 1e-05 25.4 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF1570 PF07607.11 EEA20663.1 - 0.15 12.4 0.1 0.32 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1570) Med3 PF11593.8 EEA20663.1 - 0.63 9.2 5.5 0.88 8.7 5.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Hydrolase_6 PF13344.6 EEA20664.1 - 6.6e-24 83.9 0.0 1.1e-23 83.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA20664.1 - 3.6e-18 65.4 0.0 2.1e-17 62.9 0.0 2.3 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase PF00702.26 EEA20664.1 - 1.3e-05 25.6 0.0 0.0018 18.6 0.0 2.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EEA20664.1 - 0.0048 16.7 0.0 0.0068 16.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA20664.1 - 0.0068 16.5 0.0 1.7 8.7 0.0 2.5 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA20664.1 - 0.13 12.7 0.0 5.2 7.4 0.0 3.2 3 2 1 4 4 4 0 haloacid dehalogenase-like hydrolase Epimerase PF01370.21 EEA20665.1 - 3e-20 72.7 0.0 3.9e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EEA20665.1 - 1e-08 34.7 0.1 1.4e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EEA20665.1 - 1.9e-06 27.9 0.4 2.7e-06 27.4 0.4 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA20665.1 - 1.2e-05 24.5 0.0 3.3e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EEA20665.1 - 1.8e-05 24.4 0.1 3.3e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EEA20665.1 - 6.5e-05 22.2 0.0 0.00055 19.1 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EEA20665.1 - 8e-05 22.2 0.7 0.00088 18.8 0.7 2.2 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EEA20665.1 - 0.027 13.6 0.4 5.4 6.1 0.1 2.3 1 1 1 2 2 2 0 Male sterility protein DFP PF04127.15 EEA20665.1 - 0.056 13.3 0.2 0.4 10.5 0.0 2.0 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein ADH_zinc_N PF00107.26 EEA20665.1 - 0.08 12.9 0.2 0.78 9.7 0.1 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase LRR_8 PF13855.6 EEA20666.1 - 4.1e-08 32.9 4.9 4.1e-08 32.9 4.9 2.2 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 EEA20666.1 - 0.00029 21.1 2.9 0.00029 21.1 2.9 3.5 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) EI24 PF07264.11 EEA20667.1 - 1.9e-13 51.0 3.3 2.9e-13 50.5 3.3 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) zf-RING_2 PF13639.6 EEA20668.1 - 5.4e-13 49.0 5.5 8.6e-13 48.4 5.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EEA20668.1 - 6.1e-09 35.5 2.7 6.1e-09 35.5 2.7 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA20668.1 - 6.1e-09 35.6 4.9 1e-08 34.9 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 EEA20668.1 - 8.4e-09 35.3 0.0 1.9e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.7 EEA20668.1 - 9.5e-09 35.4 3.0 2.1e-08 34.3 3.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EEA20668.1 - 1.6e-08 34.2 3.9 2.7e-08 33.6 3.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA20668.1 - 1.6e-07 31.2 3.1 2.4e-07 30.6 3.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA20668.1 - 3.3e-06 26.9 3.1 4.9e-06 26.3 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA20668.1 - 5.2e-06 26.4 2.0 1.2e-05 25.3 0.5 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EEA20668.1 - 0.001 19.1 1.0 0.002 18.1 1.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EEA20668.1 - 0.0012 18.6 2.7 0.0021 17.9 2.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EEA20668.1 - 0.026 14.7 2.3 0.063 13.4 2.3 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 EEA20668.1 - 0.051 13.8 2.8 0.13 12.4 2.8 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EEA20668.1 - 0.054 13.1 3.1 0.1 12.2 3.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EEA20668.1 - 0.37 10.9 4.4 0.69 10.1 4.4 1.5 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EEA20668.1 - 0.37 10.6 3.2 0.71 9.7 3.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EEA20668.1 - 0.39 10.7 3.2 0.7 9.8 3.2 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EEA20668.1 - 2.1 8.7 3.9 3.8 7.9 3.9 1.4 1 0 0 1 1 1 0 RING-like domain YpzI PF14140.6 EEA20669.1 - 9.9 6.0 17.4 11 5.8 0.0 5.5 6 0 0 6 6 6 0 YpzI-like protein YpzI PF14140.6 EEA20670.1 - 5.9 6.7 12.6 8.1 6.3 0.0 4.7 5 0 0 5 5 5 0 YpzI-like protein p450 PF00067.22 EEA20672.1 - 1.5e-63 215.2 0.0 2.6e-63 214.4 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Raptor_N PF14538.6 EEA20673.1 - 6.4e-66 220.8 0.0 1.2e-65 220.0 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EEA20673.1 - 7.9e-07 29.7 10.9 0.4 11.6 0.0 6.6 5 1 1 6 6 6 3 WD domain, G-beta repeat HEAT PF02985.22 EEA20673.1 - 0.0086 16.2 2.2 1.5 9.3 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat BBS2_Mid PF14783.6 EEA20673.1 - 0.016 15.2 2.5 1.3 9.1 0.3 2.9 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Atx10homo_assoc PF09759.9 EEA20673.1 - 0.15 12.1 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Kelch_4 PF13418.6 EEA20674.1 - 6.5e-32 109.3 11.8 1.5e-08 34.5 0.7 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EEA20674.1 - 5.4e-31 106.3 16.1 3.2e-07 30.5 0.2 6.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EEA20674.1 - 6.2e-30 102.5 0.6 2.1e-12 46.4 0.1 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 EEA20674.1 - 6.4e-30 102.4 7.9 4.2e-12 45.9 0.7 6.2 4 1 2 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EEA20674.1 - 4.9e-26 90.2 8.5 5.1e-07 29.5 0.1 6.8 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EEA20674.1 - 1.4e-20 72.4 10.6 1e-10 41.2 0.6 6.6 6 0 0 6 6 6 4 Kelch motif Spc7 PF08317.11 EEA20674.1 - 0.0031 16.5 21.4 0.0031 16.5 21.4 5.1 3 2 2 5 5 5 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EEA20674.1 - 0.0036 17.4 20.7 0.0036 17.4 20.7 7.2 6 2 2 8 8 8 2 TPR/MLP1/MLP2-like protein Pkinase PF00069.25 EEA20675.1 - 5.4e-26 91.5 0.0 7.4e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20675.1 - 7.5e-14 51.6 0.0 1.1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA20675.1 - 4.2e-09 35.7 0.0 7.4e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EEA20675.1 - 3.8e-05 23.7 0.1 0.0016 18.4 0.0 2.8 2 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 EEA20676.1 - 4.4e-26 91.8 0.0 6e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20676.1 - 6.2e-14 51.9 0.0 8.7e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA20676.1 - 3.7e-09 35.9 0.0 6.4e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EEA20676.1 - 3e-05 24.1 0.1 0.0015 18.5 0.0 2.8 2 1 0 3 3 3 1 Phosphotransferase enzyme family PAP1 PF08601.10 EEA20677.1 - 3e-09 37.1 10.3 1.7e-07 31.4 0.0 2.1 1 1 0 2 2 2 1 Transcription factor PAP1 bZIP_1 PF00170.21 EEA20677.1 - 1.3e-08 34.8 13.8 2.2e-08 34.1 13.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EEA20677.1 - 0.00052 20.0 16.8 0.00059 19.9 15.5 1.7 1 1 1 2 2 2 1 Basic region leucine zipper SHE3 PF17078.5 EEA20677.1 - 0.0023 17.7 4.3 0.0033 17.2 4.3 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 V_ATPase_I PF01496.19 EEA20677.1 - 0.015 13.3 3.6 0.018 13.0 3.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 EEA20677.1 - 0.021 15.5 1.1 0.039 14.6 1.1 1.4 1 0 0 1 1 1 0 Initiation control protein YabA DUF4407 PF14362.6 EEA20677.1 - 0.027 13.8 6.5 0.048 13.0 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) bZIP_Maf PF03131.17 EEA20677.1 - 0.029 14.9 13.6 0.052 14.1 13.6 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor UPF0242 PF06785.11 EEA20677.1 - 0.067 13.3 2.9 0.087 12.9 2.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 EEA20677.1 - 0.07 12.9 4.3 0.14 11.9 4.3 1.5 1 0 0 1 1 1 0 Septum formation initiator TMF_TATA_bd PF12325.8 EEA20677.1 - 0.08 13.2 5.2 0.13 12.4 5.2 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Macoilin PF09726.9 EEA20677.1 - 0.1 11.2 4.6 0.12 11.0 4.6 1.0 1 0 0 1 1 1 0 Macoilin family FlaC_arch PF05377.11 EEA20677.1 - 0.14 12.6 0.8 0.26 11.7 0.8 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) LamB_YcsF PF03746.16 EEA20677.1 - 0.16 11.7 0.2 0.23 11.1 0.2 1.2 1 0 0 1 1 1 0 LamB/YcsF family GvpL_GvpF PF06386.11 EEA20677.1 - 1.2 9.0 6.1 1.8 8.4 6.1 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF ADIP PF11559.8 EEA20677.1 - 1.8 8.6 11.6 3.2 7.8 11.6 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CENP-H PF05837.12 EEA20677.1 - 3.6 8.0 9.1 4.4 7.8 8.2 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Fungal_trans PF04082.18 EEA20678.1 - 3.2e-16 59.1 0.1 5.2e-16 58.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20678.1 - 1.5e-06 28.2 12.8 2.7e-06 27.4 12.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mannosidase_ig PF17786.1 EEA20679.1 - 1.6e-16 60.6 0.3 2.3e-15 57.0 0.0 2.6 2 1 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EEA20679.1 - 4.2e-11 43.5 0.0 1.1e-10 42.1 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EEA20679.1 - 0.0063 16.4 0.1 0.028 14.3 0.0 2.1 3 0 0 3 3 3 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 EEA20679.1 - 0.02 14.0 0.3 0.064 12.4 0.3 1.7 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Phosducin PF02114.16 EEA20680.1 - 7.7e-14 51.3 0.1 1e-13 50.8 0.1 1.2 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 EEA20680.1 - 0.016 15.2 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin U3_assoc_6 PF08640.11 EEA20680.1 - 0.082 13.0 2.1 0.18 11.9 2.1 1.5 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 Adaptin_N PF01602.20 EEA20681.1 - 1.2e-114 383.7 0.5 1.9e-114 383.1 0.5 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EEA20681.1 - 3.6e-60 202.5 4.0 8.3e-60 201.3 4.0 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EEA20681.1 - 1.8e-32 111.9 0.8 6.7e-32 110.0 0.1 2.4 3 0 0 3 3 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EEA20681.1 - 9e-17 61.2 3.7 3.7e-12 46.5 0.1 5.6 4 1 2 6 6 6 1 HEAT repeats Cnd1 PF12717.7 EEA20681.1 - 6.2e-08 32.8 9.9 0.0023 18.0 0.2 4.8 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EEA20681.1 - 0.0016 18.5 5.1 0.39 11.1 0.2 5.1 6 0 0 6 6 4 1 HEAT repeat HEAT_PBS PF03130.16 EEA20681.1 - 0.0072 16.9 0.3 4.4 8.3 0.0 4.4 4 0 0 4 4 3 1 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 EEA20681.1 - 0.013 16.0 0.7 0.063 13.8 0.7 2.2 1 0 0 1 1 1 0 HEAT-like repeat E2F_CC-MB PF16421.5 EEA20681.1 - 0.057 13.8 0.1 0.28 11.6 0.1 2.2 1 0 0 1 1 1 0 E2F transcription factor CC-MB domain DUF5010 PF16402.5 EEA20681.1 - 0.065 12.1 0.0 0.79 8.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5010) DUF2057 PF09829.9 EEA20681.1 - 0.067 13.4 1.9 0.19 11.9 1.9 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) UNC45-central PF11701.8 EEA20681.1 - 1.5 8.7 5.1 41 4.1 0.1 4.0 5 0 0 5 5 5 0 Myosin-binding striated muscle assembly central F-box-like PF12937.7 EEA20682.1 - 4.2e-08 33.0 0.1 1.1e-07 31.7 0.1 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EEA20682.1 - 2.2 8.8 12.1 5 7.7 0.2 4.4 4 2 2 6 6 6 0 Leucine Rich repeats (2 copies) Romo1 PF10247.9 EEA20685.1 - 2.3e-25 88.7 17.5 2.8e-25 88.5 17.5 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 EEA20685.1 - 0.036 14.4 3.9 0.041 14.3 3.9 1.1 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family FHA PF00498.26 EEA20686.1 - 9.2e-17 61.2 0.0 2.4e-16 59.8 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EEA20686.1 - 0.00033 20.9 0.0 0.0011 19.3 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Rpp20 PF12328.8 EEA20687.1 - 5.6e-50 168.9 13.1 5e-48 162.5 13.1 2.8 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EEA20687.1 - 5.5e-17 61.4 0.1 1e-16 60.5 0.1 1.4 1 0 0 1 1 1 1 Alba CDC45 PF02724.14 EEA20687.1 - 0.022 13.1 9.8 0.027 12.8 9.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2786 PF10979.8 EEA20687.1 - 0.22 11.5 1.0 0.51 10.3 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) Spt5_N PF11942.8 EEA20687.1 - 0.26 12.3 18.3 0.68 11.0 18.3 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Glyco_transf_24 PF18404.1 EEA20690.1 - 1.6e-148 493.4 1.8 2.8e-148 492.6 1.8 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EEA20690.1 - 1.5e-65 221.7 0.0 8.6e-64 215.9 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EEA20690.1 - 4.3e-50 170.2 0.0 2.1e-49 168.0 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 EEA20690.1 - 7.3e-46 156.8 0.2 3.4e-43 148.1 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EEA20690.1 - 1.3e-41 141.7 1.2 2.5e-40 137.5 0.0 3.4 5 0 0 5 5 5 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EEA20690.1 - 6.1e-40 135.7 0.0 1.4e-39 134.6 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 EEA20690.1 - 0.0014 18.2 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Myb_DNA-binding PF00249.31 EEA20691.1 - 1.2e-13 51.1 8.7 2e-06 27.9 0.3 3.5 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA20691.1 - 4.4e-10 39.7 8.7 1.5e-08 34.8 0.7 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EEA20691.1 - 1.3 9.4 4.7 1.5 9.2 0.8 2.7 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain KH_6 PF15985.5 EEA20692.1 - 2.5e-17 62.9 0.0 5.9e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EEA20692.1 - 7.8e-07 28.9 0.5 2.3e-06 27.5 0.5 1.9 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain HSP70 PF00012.20 EEA20693.1 - 1.7e-78 264.3 3.0 1.7e-78 264.3 3.0 1.7 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EEA20693.1 - 3.4e-07 29.4 0.5 5.8e-07 28.6 0.5 1.3 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 EEA20693.1 - 0.025 13.6 0.1 3.9 6.4 0.0 2.9 2 1 1 3 3 3 0 Type IV pilus assembly protein PilM; DUF3221 PF11518.8 EEA20693.1 - 0.089 13.2 1.5 0.25 11.7 1.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3221) Vpu PF00558.19 EEA20693.1 - 0.77 9.6 2.8 1.5 8.6 2.8 1.4 1 0 0 1 1 1 0 Vpu protein SUR7 PF06687.12 EEA20694.1 - 2.6e-41 141.6 7.7 3e-41 141.4 7.7 1.0 1 0 0 1 1 1 1 SUR7/PalI family Clc-like PF07062.12 EEA20694.1 - 1.7e-05 24.4 0.2 3e-05 23.6 0.2 1.4 1 0 0 1 1 1 1 Clc-like Amastin PF07344.11 EEA20694.1 - 0.00086 19.2 6.3 0.005 16.7 3.6 2.1 1 1 1 2 2 2 1 Amastin surface glycoprotein SUR7 PF06687.12 EEA20695.1 - 2.5e-37 128.6 4.4 2.9e-37 128.4 4.4 1.0 1 0 0 1 1 1 1 SUR7/PalI family Clc-like PF07062.12 EEA20695.1 - 1.6e-05 24.5 0.2 2.4e-05 23.9 0.2 1.3 1 0 0 1 1 1 1 Clc-like Amastin PF07344.11 EEA20695.1 - 0.0016 18.3 2.9 0.0025 17.7 2.9 1.3 1 0 0 1 1 1 1 Amastin surface glycoprotein Rogdi_lz PF10259.9 EEA20696.1 - 4.2e-84 282.2 0.0 4.8e-84 282.0 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Rsm22 PF09243.10 EEA20697.1 - 2.4e-30 105.8 0.0 2.6e-29 102.4 0.0 2.7 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 DASH_Spc19 PF08287.11 EEA20698.1 - 4e-51 173.0 4.5 5.4e-51 172.6 4.5 1.2 1 0 0 1 1 1 1 Spc19 Mur_ligase_M PF08245.12 EEA20698.1 - 0.002 18.2 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain COG5 PF10392.9 EEA20698.1 - 0.91 9.7 7.2 12 6.1 0.3 3.0 2 1 1 3 3 3 0 Golgi transport complex subunit 5 ATP-synt_J PF04911.12 EEA20699.1 - 3.3e-27 93.8 3.2 3.6e-27 93.7 3.2 1.0 1 0 0 1 1 1 1 ATP synthase j chain Parecho_VpG PF06344.11 EEA20699.1 - 1 10.1 4.7 10 7.0 0.3 2.3 2 0 0 2 2 2 0 Parechovirus Genome-linked protein ATP-synt_J PF04911.12 EEA20700.1 - 1.3e-16 59.9 0.8 1.5e-16 59.7 0.8 1.2 1 0 0 1 1 1 1 ATP synthase j chain ATP-synt_J PF04911.12 EEA20701.1 - 1.9e-15 56.2 0.1 2.4e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 ATP synthase j chain ATP-synt_J PF04911.12 EEA20702.1 - 1.9e-15 56.2 0.1 2.4e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 ATP synthase j chain Ribosomal_S14 PF00253.21 EEA20703.1 - 1.8e-21 75.6 2.7 2.9e-21 75.0 0.3 2.0 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Synaphin PF05835.12 EEA20703.1 - 0.26 11.6 1.0 0.36 11.1 1.0 1.2 1 0 0 1 1 1 0 Synaphin protein Amidohydro_1 PF01979.20 EEA20705.1 - 1.4e-26 93.6 0.0 1.2e-25 90.5 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA20705.1 - 2e-13 50.7 0.1 2.1e-08 34.1 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Vma12 PF11712.8 EEA20706.1 - 2.1e-40 138.0 0.0 2.8e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase LapA_dom PF06305.11 EEA20706.1 - 0.096 12.5 0.1 0.096 12.5 0.1 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Prefoldin PF02996.17 EEA20707.1 - 3.3e-28 98.0 1.7 3.3e-28 98.0 1.7 1.7 2 1 0 2 2 2 1 Prefoldin subunit Prefoldin_2 PF01920.20 EEA20707.1 - 0.0039 17.1 0.6 0.016 15.1 0.0 2.1 2 1 0 2 2 2 1 Prefoldin subunit Syntaxin-6_N PF09177.11 EEA20707.1 - 0.015 15.8 0.7 1 10.0 0.1 2.3 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF4201 PF13870.6 EEA20707.1 - 0.016 15.0 4.0 0.61 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) CSN8_PSD8_EIF3K PF10075.9 EEA20708.1 - 1.9e-48 164.1 0.0 2.4e-48 163.8 0.0 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Folliculin PF11704.8 EEA20709.1 - 7.4e-54 182.5 0.9 2e-53 181.1 0.0 2.1 3 0 0 3 3 3 1 Vesicle coat protein involved in Golgi to plasma membrane transport Fungal_trans PF04082.18 EEA20710.1 - 0.0023 17.0 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20710.1 - 0.056 13.6 9.8 0.11 12.6 9.8 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_polI_A34 PF08208.11 EEA20711.1 - 3.4e-39 135.1 51.0 8.3e-39 133.8 39.3 3.0 2 1 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 PPP4R2 PF09184.11 EEA20711.1 - 0.99 8.9 25.9 0.29 10.7 15.3 2.1 2 0 0 2 2 2 0 PPP4R2 PNISR PF15996.5 EEA20711.1 - 8.3 6.6 29.8 9.2 6.5 21.4 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR CLP1_P PF16575.5 EEA20712.1 - 9.7e-26 90.7 0.0 1.9e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EEA20712.1 - 0.0061 16.8 0.6 0.19 12.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA20712.1 - 0.033 14.8 0.2 0.22 12.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EEA20712.1 - 0.041 13.6 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 EEA20712.1 - 0.058 13.8 0.0 0.34 11.3 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 EEA20712.1 - 0.076 13.2 2.2 0.41 10.8 0.1 2.9 2 1 1 3 3 3 0 AAA domain AAA_24 PF13479.6 EEA20712.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA20712.1 - 0.24 11.7 5.0 3.9 7.8 0.0 3.6 4 0 0 4 4 4 0 AAA ATPase domain AAA_23 PF13476.6 EEA20712.1 - 0.25 11.8 3.3 0.96 9.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain PDCD2_C PF04194.13 EEA20713.1 - 8.1e-41 140.0 0.0 1.2e-40 139.4 0.0 1.3 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain zf-RING_7 PF02591.15 EEA20713.1 - 0.073 13.3 0.2 0.14 12.3 0.2 1.5 1 0 0 1 1 1 0 C4-type zinc ribbon domain Prenylcys_lyase PF07156.14 EEA20714.1 - 4.7e-101 338.5 0.1 6e-101 338.2 0.1 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 EEA20714.1 - 1.3e-12 47.8 0.0 2.8e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EEA20714.1 - 1.9e-11 43.9 0.0 5.4e-11 42.5 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 EEA20714.1 - 3.6e-06 26.8 0.3 6.9e-06 25.9 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA20714.1 - 0.0011 18.2 0.1 0.0035 16.6 0.0 1.7 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 EEA20714.1 - 0.0055 16.7 0.0 0.061 13.3 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EEA20714.1 - 0.014 14.6 0.0 0.044 13.0 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA20714.1 - 0.13 12.8 0.1 6.2 7.5 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HsbA PF12296.8 EEA20715.1 - 1.3e-21 77.3 13.8 1.3e-21 77.3 13.8 2.5 3 0 0 3 3 3 1 Hydrophobic surface binding protein A EVI2A PF05399.11 EEA20715.1 - 1 8.9 7.2 1.8 8.1 7.2 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) HsbA PF12296.8 EEA20716.1 - 1.9e-27 96.1 10.6 1.9e-27 96.1 10.6 1.6 2 0 0 2 2 2 1 Hydrophobic surface binding protein A GRAM PF02893.20 EEA20717.1 - 8.7e-33 112.6 0.5 4.2e-21 75.0 0.0 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 EEA20717.1 - 9.1e-27 93.8 0.0 1.7e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 EEA20717.1 - 1.6e-15 57.5 1.4 3e-14 53.4 0.1 3.2 4 0 0 4 4 4 1 PH domain PH_8 PF15409.6 EEA20717.1 - 8.7e-05 22.7 0.1 0.00026 21.2 0.1 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EEA20717.1 - 0.00027 21.3 0.8 0.00027 21.3 0.8 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain UDPGT PF00201.18 EEA20717.1 - 0.00064 18.6 0.0 0.0013 17.7 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_3 PF14593.6 EEA20717.1 - 0.00071 19.7 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EEA20717.1 - 0.067 13.6 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain GnsAB_toxin PF08178.11 EEA20717.1 - 0.19 11.7 0.1 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system Ndc1_Nup PF09531.10 EEA20717.1 - 8.2 5.0 10.6 4.8 5.8 1.9 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SHMT PF00464.19 EEA20718.1 - 3.6e-208 691.0 0.0 4.1e-208 690.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 EEA20718.1 - 0.0063 15.8 0.0 0.011 15.0 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EEA20718.1 - 0.13 10.8 0.1 0.32 9.5 0.0 1.6 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Baculo_DNA_bind PF04786.12 EEA20718.1 - 0.16 11.3 0.0 0.44 9.9 0.0 1.6 2 0 0 2 2 2 0 ssDNA binding protein Med9 PF07544.13 EEA20719.1 - 5.6e-17 61.6 0.0 1.2e-16 60.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 EEA20719.1 - 0.003 17.8 1.7 0.003 17.8 1.7 1.9 2 0 0 2 2 2 1 Subunit 21 of Mediator complex DUF2680 PF10925.8 EEA20719.1 - 0.071 13.1 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) DUF4515 PF14988.6 EEA20719.1 - 0.071 12.9 0.2 0.097 12.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) XhlA PF10779.9 EEA20719.1 - 0.096 12.9 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 Haemolysin XhlA Csm1_N PF18504.1 EEA20719.1 - 0.18 12.2 0.1 0.18 12.2 0.1 1.7 2 0 0 2 2 2 0 Csm1 N-terminal domain GP41 PF00517.17 EEA20719.1 - 0.19 11.6 0.2 0.26 11.2 0.2 1.1 1 0 0 1 1 1 0 Retroviral envelope protein KCT2 PF17818.1 EEA20719.1 - 1.2 9.3 4.0 0.16 12.1 0.3 1.4 2 0 0 2 2 2 0 Keratinocyte-associated gene product iPGM_N PF06415.13 EEA20720.1 - 1.3e-73 247.1 0.0 1.7e-73 246.7 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EEA20720.1 - 6.7e-72 241.8 0.0 7.7e-72 241.6 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 EEA20720.1 - 9.8e-06 25.4 0.0 1.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EEA20720.1 - 8.1e-05 22.1 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Sulfatase Alk_phosphatase PF00245.20 EEA20720.1 - 0.044 12.7 0.1 0.23 10.3 0.0 2.0 2 0 0 2 2 2 0 Alkaline phosphatase AP_endonuc_2 PF01261.24 EEA20720.1 - 0.07 12.6 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Prefoldin_2 PF01920.20 EEA20721.1 - 5.4e-21 74.5 17.3 7.3e-21 74.1 17.3 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 EEA20721.1 - 0.00018 21.5 5.9 0.00028 20.9 5.9 1.3 1 0 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.11 EEA20721.1 - 0.00037 20.7 12.0 0.084 13.1 5.6 2.1 2 0 0 2 2 2 2 Spc24 subunit of Ndc80 Spc7 PF08317.11 EEA20721.1 - 0.014 14.3 17.0 0.019 13.9 17.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein XhlA PF10779.9 EEA20721.1 - 0.016 15.4 1.6 0.016 15.4 1.6 2.0 2 1 0 2 2 2 0 Haemolysin XhlA Myosin_tail_1 PF01576.19 EEA20721.1 - 0.02 12.8 12.7 0.026 12.3 12.7 1.1 1 0 0 1 1 1 0 Myosin tail Rx_N PF18052.1 EEA20721.1 - 0.081 13.2 10.2 0.82 10.0 3.3 2.2 2 0 0 2 2 2 0 Rx N-terminal domain Prefoldin PF02996.17 EEA20721.1 - 0.14 12.1 18.1 5.7 6.9 18.1 2.6 1 1 0 1 1 1 0 Prefoldin subunit CENP-F_leu_zip PF10473.9 EEA20721.1 - 0.16 12.0 15.5 0.83 9.7 5.4 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 EEA20721.1 - 0.21 11.4 23.2 0.33 10.8 2.8 3.2 2 1 1 3 3 3 0 Septum formation initiator EzrA PF06160.12 EEA20721.1 - 0.25 9.5 14.4 0.17 10.1 3.7 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA HalX PF08663.10 EEA20721.1 - 0.33 11.3 8.8 3.9 7.9 0.1 2.9 2 1 0 2 2 2 0 HalX domain YabA PF06156.13 EEA20721.1 - 0.35 11.5 11.8 2.4 8.8 1.3 2.1 2 0 0 2 2 2 0 Initiation control protein YabA PHM7_cyt PF14703.6 EEA20721.1 - 0.57 10.4 6.7 0.92 9.7 6.7 1.4 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter CALCOCO1 PF07888.11 EEA20721.1 - 0.65 8.8 15.7 19 4.0 14.0 2.1 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-H PF05837.12 EEA20721.1 - 0.71 10.3 13.8 0.22 12.0 1.2 2.3 2 1 0 2 2 2 0 Centromere protein H (CENP-H) ERp29 PF07749.12 EEA20721.1 - 0.96 10.4 6.2 3.9 8.4 6.1 2.0 1 1 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain TMF_TATA_bd PF12325.8 EEA20721.1 - 1.1 9.5 17.3 2.8 8.2 3.5 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Taxilin PF09728.9 EEA20721.1 - 1.1 8.4 17.6 15 4.6 17.7 2.0 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Csm1_N PF18504.1 EEA20721.1 - 1.1 9.6 19.2 1.4 9.3 1.9 3.9 2 2 1 3 3 3 0 Csm1 N-terminal domain DUF4200 PF13863.6 EEA20721.1 - 1.2 9.5 17.0 4.6 7.7 4.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) NPV_P10 PF05531.12 EEA20721.1 - 1.3 9.5 13.3 0.89 10.1 2.4 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein End3 PF12761.7 EEA20721.1 - 1.4 9.0 11.9 1.9 8.6 11.9 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF4349 PF14257.6 EEA20721.1 - 1.8 8.0 15.4 0.048 13.1 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) ABC_tran_CTD PF16326.5 EEA20721.1 - 2 8.8 20.6 1.6 9.0 1.9 3.3 2 2 1 3 3 3 0 ABC transporter C-terminal domain Bcr-Abl_Oligo PF09036.10 EEA20721.1 - 2.4 8.2 5.6 1 9.4 0.8 2.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain FlaC_arch PF05377.11 EEA20721.1 - 2.6 8.5 12.5 5.1 7.6 1.9 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) GrpE PF01025.19 EEA20721.1 - 2.6 7.7 13.1 5.4 6.6 3.7 2.2 2 0 0 2 2 2 0 GrpE DUF4407 PF14362.6 EEA20721.1 - 2.7 7.3 14.3 6.6 6.0 14.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EEA20721.1 - 3.2 7.9 17.5 66 3.7 17.5 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 EEA20721.1 - 3.4 8.2 22.0 4 8.0 5.1 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Rootletin PF15035.6 EEA20721.1 - 4.1 7.4 14.2 0.91 9.5 7.0 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion MCU PF04678.13 EEA20721.1 - 4.3 7.4 7.9 46 4.0 7.9 2.0 1 1 0 1 1 1 0 Mitochondrial calcium uniporter BRE1 PF08647.11 EEA20721.1 - 4.7 7.3 17.0 0.45 10.6 2.3 2.4 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase OmpH PF03938.14 EEA20721.1 - 5.2 7.4 27.3 4.4 7.6 13.3 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) ERM PF00769.19 EEA20721.1 - 7.9 6.2 19.9 2.1e+02 1.6 19.9 2.0 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 EEA20721.1 - 8.2 6.5 12.7 5.1 7.2 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CorA PF01544.18 EEA20721.1 - 9.4 5.5 8.0 1.9 7.8 0.4 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein AAA PF00004.29 EEA20722.1 - 2.3e-42 144.6 0.0 4.5e-42 143.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EEA20722.1 - 1.9e-30 104.6 0.0 7.7e-30 102.7 0.0 2.1 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EEA20722.1 - 5.4e-23 80.8 2.2 5.4e-23 80.8 2.2 2.0 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 EEA20722.1 - 1.2e-05 25.1 0.0 2.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA20722.1 - 1.3e-05 25.7 0.0 0.00016 22.1 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EEA20722.1 - 2.7e-05 24.2 0.0 0.00012 22.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EEA20722.1 - 5e-05 23.6 0.0 0.011 16.1 0.0 2.8 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 EEA20722.1 - 7.3e-05 22.6 0.0 0.00016 21.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 EEA20722.1 - 9.6e-05 21.7 0.0 0.00057 19.1 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EEA20722.1 - 0.00012 22.3 0.1 0.019 15.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EEA20722.1 - 0.00013 21.3 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EEA20722.1 - 0.00032 20.7 0.0 0.00068 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA20722.1 - 0.00045 20.8 0.1 0.002 18.7 0.0 2.2 2 1 0 2 2 1 1 AAA domain AAA_lid_3 PF17862.1 EEA20722.1 - 0.00075 19.3 0.0 0.025 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA+ lid domain AAA_2 PF07724.14 EEA20722.1 - 0.00095 19.3 0.0 0.0082 16.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EEA20722.1 - 0.0017 18.5 0.0 0.0039 17.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EEA20722.1 - 0.0028 17.4 0.1 0.011 15.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EEA20722.1 - 0.0051 17.2 0.0 0.037 14.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EEA20722.1 - 0.0098 15.5 0.3 0.64 9.6 0.1 2.8 2 1 1 3 3 3 1 AAA domain AAA_7 PF12775.7 EEA20722.1 - 0.016 14.7 0.1 0.089 12.3 0.0 2.2 2 1 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EEA20722.1 - 0.02 14.3 0.1 0.071 12.5 0.1 2.0 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 EEA20722.1 - 0.035 14.2 0.1 0.095 12.8 0.0 1.7 2 0 0 2 2 1 0 Torsin Parvo_NS1 PF01057.17 EEA20722.1 - 0.054 12.6 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 EEA20722.1 - 0.059 13.3 0.1 1.3 8.9 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea USP8_dimer PF08969.11 EEA20722.1 - 0.061 13.5 1.9 0.13 12.5 1.9 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain PhoH PF02562.16 EEA20722.1 - 0.079 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EEA20722.1 - 0.083 12.8 0.0 0.67 9.9 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EEA20722.1 - 0.14 11.8 0.0 0.49 10.1 0.0 2.0 2 1 0 2 2 1 0 Sigma-54 interaction domain AFG1_ATPase PF03969.16 EEA20722.1 - 0.14 11.0 0.0 0.29 10.0 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase Cytidylate_kin PF02224.18 EEA20722.1 - 0.17 11.6 1.7 0.51 10.0 0.0 2.5 2 1 0 2 2 2 0 Cytidylate kinase Use1 PF09753.9 EEA20722.1 - 0.19 11.5 0.8 0.34 10.6 0.8 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 ATPase PF06745.13 EEA20722.1 - 0.22 10.8 0.2 8.5 5.6 0.0 2.7 2 1 1 3 3 3 0 KaiC Tcp11 PF05794.13 EEA20723.1 - 1.2e-115 387.1 0.4 1.2e-115 387.1 0.4 3.2 3 1 0 3 3 3 1 T-complex protein 11 UPF0242 PF06785.11 EEA20723.1 - 9.6 6.3 12.6 29 4.7 8.8 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus WD40 PF00400.32 EEA20724.1 - 4.8e-32 109.5 22.4 2.6e-07 31.2 0.0 8.1 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20724.1 - 3.9e-11 43.1 4.8 0.082 13.2 0.1 5.9 5 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PCSK9_C1 PF18459.1 EEA20724.1 - 0.074 13.2 0.1 2 8.6 0.0 3.1 3 0 0 3 3 3 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain GOLD_2 PF13897.6 EEA20724.1 - 0.3 11.6 2.2 0.61 10.6 0.4 2.3 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Endosulfine PF04667.17 EEA20725.1 - 7.7e-29 99.7 0.0 1.3e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region RNA_Me_trans PF04252.13 EEA20726.1 - 6.6e-75 251.1 0.0 7.5e-75 250.9 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Peptidase_S10 PF00450.22 EEA20727.1 - 2.1e-118 396.4 0.0 2.5e-118 396.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase ICE2 PF08426.10 EEA20728.1 - 5.3e-155 516.5 10.4 6.1e-155 516.3 10.4 1.0 1 0 0 1 1 1 1 ICE2 WD40 PF00400.32 EEA20729.1 - 2.9e-17 62.7 1.3 0.0051 17.6 0.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat Yae1_N PF09811.9 EEA20729.1 - 4.1e-06 26.4 1.2 4.1e-06 26.4 1.2 2.7 3 0 0 3 3 3 1 Essential protein Yae1, N terminal ANAPC4_WD40 PF12894.7 EEA20729.1 - 5.6e-05 23.4 0.0 0.64 10.4 0.0 5.0 2 2 5 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA20729.1 - 0.0052 15.8 0.1 0.029 13.3 0.0 2.2 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EEA20729.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain Nup160 PF11715.8 EEA20729.1 - 0.092 11.4 0.0 0.29 9.7 0.0 1.7 2 0 0 2 2 2 0 Nucleoporin Nup120/160 FliO PF04347.13 EEA20729.1 - 0.14 12.5 0.0 0.55 10.6 0.0 1.9 2 0 0 2 2 2 0 Flagellar biosynthesis protein, FliO IPU_b_solenoid PF18783.1 EEA20730.1 - 0.052 13.6 0.2 0.55 10.3 0.0 2.4 2 0 0 2 2 2 0 Isopullulanase beta-solenoid repeat HHH_4 PF14490.6 EEA20730.1 - 0.09 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix containing domain Abhydrolase_1 PF00561.20 EEA20731.1 - 1.6e-09 37.8 0.2 8.1e-09 35.5 0.0 2.3 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA20731.1 - 4.3e-08 34.0 0.4 5e-07 30.5 0.4 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA20731.1 - 2.7e-05 23.5 0.0 0.00023 20.5 0.0 2.3 3 0 0 3 3 3 1 Serine aminopeptidase, S33 DUF724 PF05266.14 EEA20731.1 - 0.39 10.5 5.1 0.8 9.5 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Helo_like_N PF17111.5 EEA20732.1 - 3e-88 294.6 7.1 1.2e-78 263.2 0.7 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins Spc7 PF08317.11 EEA20732.1 - 0.00014 20.8 9.8 0.22 10.4 0.1 3.2 3 0 0 3 3 3 3 Spc7 kinetochore protein SesA PF17107.5 EEA20732.1 - 0.00048 20.3 5.5 0.091 13.0 0.0 3.3 3 0 0 3 3 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1664 PF07889.12 EEA20732.1 - 0.00072 19.6 9.2 1.2 9.1 0.0 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1664) PilJ PF13675.6 EEA20732.1 - 0.011 15.8 2.3 2.5 8.1 0.0 3.3 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term RasGAP_C PF03836.15 EEA20732.1 - 0.012 15.8 10.2 0.042 14.0 0.0 3.8 3 1 0 3 3 3 0 RasGAP C-terminus CLZ PF16526.5 EEA20732.1 - 0.029 14.7 10.1 0.6 10.5 0.4 3.6 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels COG2 PF06148.11 EEA20732.1 - 0.09 12.9 14.1 1.7 8.7 0.4 3.9 4 1 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Apolipoprotein PF01442.18 EEA20732.1 - 0.1 12.5 10.0 0.68 9.8 0.3 3.5 4 0 0 4 4 4 0 Apolipoprotein A1/A4/E domain PI3K_P85_iSH2 PF16454.5 EEA20732.1 - 0.2 11.2 11.0 7 6.2 0.8 3.5 3 0 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain COG5 PF10392.9 EEA20732.1 - 0.26 11.5 10.5 3.3 7.9 0.0 3.6 4 0 0 4 4 4 0 Golgi transport complex subunit 5 DASH_Dad2 PF08654.10 EEA20732.1 - 0.6 10.6 9.4 5.1 7.6 0.3 3.9 3 1 0 3 3 3 0 DASH complex subunit Dad2 NPV_P10 PF05531.12 EEA20732.1 - 0.71 10.4 7.2 8.3 7.0 0.1 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 EEA20732.1 - 1.4 9.6 11.3 9.7 6.9 0.4 4.0 3 1 0 3 3 3 0 SlyX DUF4363 PF14276.6 EEA20732.1 - 1.7 8.8 5.4 1 9.5 0.4 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) Spore_III_AB PF09548.10 EEA20732.1 - 3.5 7.7 8.3 1.1 9.3 0.0 3.2 4 0 0 4 4 3 0 Stage III sporulation protein AB (spore_III_AB) KxDL PF10241.9 EEA20732.1 - 3.5 8.0 12.9 22 5.4 0.7 4.0 4 0 0 4 4 3 0 Uncharacterized conserved protein ING PF12998.7 EEA20732.1 - 3.5 8.3 12.4 5 7.8 1.5 3.7 4 0 0 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding DUF2205 PF10224.9 EEA20732.1 - 4.8 7.3 13.3 6 7.0 0.3 4.5 3 1 0 4 4 4 0 Short coiled-coil protein Seryl_tRNA_N PF02403.22 EEA20732.1 - 7.7 6.8 14.3 5.6 7.2 0.0 4.0 4 2 0 4 4 3 0 Seryl-tRNA synthetase N-terminal domain Plk4_PB2 PF18409.1 EEA20732.1 - 8.7 7.1 11.5 0.9 10.3 0.3 3.7 4 1 0 4 4 3 0 Polo-like Kinase 4 Polo Box 2 YlqD PF11068.8 EEA20732.1 - 9.7 6.6 16.9 1.2 9.5 3.0 3.7 4 0 0 4 4 4 0 YlqD protein zf-3CxxC PF13695.6 EEA20733.1 - 8.6e-20 71.1 0.7 1.6e-19 70.2 0.2 1.6 2 0 0 2 2 2 1 Zinc-binding domain ESAG1 PF03238.13 EEA20733.1 - 0.028 13.9 0.2 0.033 13.6 0.2 1.1 1 0 0 1 1 1 0 ESAG protein Dynamin_M PF01031.20 EEA20734.1 - 2.2e-10 40.2 2.5 4.5e-07 29.4 0.2 3.0 2 1 1 3 3 3 2 Dynamin central region GED PF02212.18 EEA20734.1 - 4.8e-07 29.9 0.0 1.6e-06 28.2 0.0 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain Dynamin_N PF00350.23 EEA20735.1 - 6.9e-32 110.8 0.0 1.7e-31 109.6 0.0 1.6 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EEA20735.1 - 3.8e-05 23.7 0.1 0.00034 20.7 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EEA20735.1 - 0.033 14.0 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TniB PF05621.11 EEA20735.1 - 0.094 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 EEA20735.1 - 0.11 12.9 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EEA20735.1 - 0.12 12.2 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 EEA20735.1 - 0.13 11.8 0.0 14 5.2 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA20736.1 - 3.1e-35 121.7 0.2 3.1e-35 121.7 0.2 1.8 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 EEA20736.1 - 7.2e-24 84.5 0.1 6.5e-18 65.0 0.0 2.7 1 1 1 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EEA20736.1 - 4.3e-05 23.6 0.1 0.00041 20.4 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EEA20736.1 - 0.029 14.5 0.1 0.14 12.3 0.1 2.3 1 0 0 1 1 1 0 Dynamin GTPase effector domain AAA_15 PF13175.6 EEA20736.1 - 0.037 13.7 1.6 0.9 9.2 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain NACHT_N PF17100.5 EEA20736.1 - 0.11 12.4 0.6 0.19 11.6 0.6 1.4 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase Roc PF08477.13 EEA20736.1 - 0.13 12.5 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF3237 PF11578.8 EEA20737.1 - 3.2e-29 101.7 0.1 3.6e-29 101.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) SLAC1 PF03595.17 EEA20738.1 - 3.2e-57 194.2 34.2 3.2e-57 194.2 34.2 2.5 2 1 0 2 2 1 1 Voltage-dependent anion channel ABC2_membrane PF01061.24 EEA20738.1 - 1.7e-26 92.9 33.4 1.7e-26 92.9 33.4 3.8 3 2 0 3 3 1 1 ABC-2 type transporter ABC_tran PF00005.27 EEA20738.1 - 1.8e-25 90.0 0.1 3.1e-25 89.3 0.1 1.4 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EEA20738.1 - 8.6e-05 23.0 0.4 0.00024 21.6 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EEA20738.1 - 0.00012 22.1 0.0 0.26 11.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA20738.1 - 0.00023 20.7 0.1 0.00097 18.6 0.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EEA20738.1 - 0.00074 19.2 0.1 0.0015 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EEA20738.1 - 0.00083 19.1 0.1 0.0022 17.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA20738.1 - 0.0018 18.5 0.0 0.0039 17.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EEA20738.1 - 0.0019 18.2 0.1 0.006 16.5 0.1 1.9 2 0 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 EEA20738.1 - 0.0048 16.0 0.1 0.0082 15.2 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EEA20738.1 - 0.0059 16.3 0.3 0.012 15.3 0.3 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EEA20738.1 - 0.015 15.8 0.2 0.034 14.7 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EEA20738.1 - 0.016 15.4 0.1 0.045 14.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA20738.1 - 0.02 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 EEA20738.1 - 0.023 14.6 0.1 0.053 13.4 0.1 1.6 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.23 EEA20738.1 - 0.028 14.5 0.0 0.072 13.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EEA20738.1 - 0.035 14.7 0.0 0.082 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EEA20738.1 - 0.037 14.5 0.0 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EEA20738.1 - 0.073 13.2 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EEA20738.1 - 0.076 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA20738.1 - 0.077 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 NTPase cobW PF02492.19 EEA20738.1 - 0.083 12.5 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EEA20738.1 - 0.096 11.9 0.5 0.43 9.7 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EEA20738.1 - 0.096 12.6 0.0 0.63 9.9 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Cytidylate_kin PF02224.18 EEA20738.1 - 0.1 12.3 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_13 PF13166.6 EEA20738.1 - 0.11 11.1 0.1 0.34 9.5 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_35 PF14516.6 EEA20738.1 - 0.12 11.2 0.3 0.21 10.4 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain AAA_19 PF13245.6 EEA20738.1 - 0.18 12.1 0.1 0.43 10.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EEA20740.1 - 1.6e-48 164.7 0.0 1.1e-29 103.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA20740.1 - 7e-28 98.0 35.4 1e-20 74.5 16.8 2.8 2 1 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EEA20740.1 - 1.9e-12 47.6 0.3 0.00096 19.0 0.1 4.4 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA20740.1 - 6.3e-11 42.1 0.9 0.048 13.1 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA20740.1 - 1e-07 31.6 0.2 0.0093 15.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA20740.1 - 1.8e-07 31.7 0.3 0.0061 17.0 0.0 3.4 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EEA20740.1 - 4.8e-06 26.9 0.3 0.067 13.5 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_23 PF13476.6 EEA20740.1 - 2.3e-05 25.0 4.1 0.0048 17.4 0.0 3.3 4 0 0 4 4 3 1 AAA domain MMR_HSR1 PF01926.23 EEA20740.1 - 5.1e-05 23.3 0.0 0.071 13.2 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.17 EEA20740.1 - 6.6e-05 23.1 2.3 0.00031 20.9 0.5 2.6 2 1 1 3 3 3 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 EEA20740.1 - 7.8e-05 22.6 0.2 0.65 9.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase FtsK_SpoIIIE PF01580.18 EEA20740.1 - 0.00031 20.2 0.0 0.039 13.3 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_18 PF13238.6 EEA20740.1 - 0.00065 20.2 0.0 2 9.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EEA20740.1 - 0.0011 18.6 0.0 0.015 14.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EEA20740.1 - 0.0021 17.7 1.2 1 8.9 0.2 2.7 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EEA20740.1 - 0.0022 18.2 0.0 1.5 9.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EEA20740.1 - 0.0024 17.0 0.1 1.9 7.5 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein RNA_helicase PF00910.22 EEA20740.1 - 0.0041 17.5 0.1 4.6 7.7 0.0 3.1 2 0 0 2 2 2 1 RNA helicase Dynamin_N PF00350.23 EEA20740.1 - 0.0044 17.1 0.1 1.2 9.2 0.0 2.6 2 0 0 2 2 2 1 Dynamin family dNK PF01712.19 EEA20740.1 - 0.008 16.1 0.4 0.16 11.8 0.0 2.3 2 0 0 2 2 2 1 Deoxynucleoside kinase ATPase_2 PF01637.18 EEA20740.1 - 0.0094 15.9 0.1 0.24 11.3 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EEA20740.1 - 0.0097 15.8 0.2 4.4 7.2 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 EEA20740.1 - 0.01 15.3 0.1 0.78 9.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Adeno_IVa2 PF02456.15 EEA20740.1 - 0.012 14.4 0.1 0.43 9.3 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_15 PF13175.6 EEA20740.1 - 0.012 15.3 0.0 6.4 6.4 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain NTPase_1 PF03266.15 EEA20740.1 - 0.016 15.1 1.0 6.3 6.7 0.3 2.6 2 0 0 2 2 2 0 NTPase MeaB PF03308.16 EEA20740.1 - 0.026 13.5 0.3 0.12 11.3 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 EEA20740.1 - 0.034 14.2 0.0 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EEA20740.1 - 0.04 13.8 0.7 0.2 11.6 0.1 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain Viral_helicase1 PF01443.18 EEA20740.1 - 0.043 13.6 0.1 1.8 8.2 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 EEA20740.1 - 0.049 13.7 0.0 0.51 10.4 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.14 EEA20740.1 - 0.075 13.0 0.1 9.4 6.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EEA20740.1 - 0.1 12.3 0.1 6.6 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EEA20740.1 - 0.1 13.0 0.2 6.4 7.2 0.1 3.7 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 EEA20740.1 - 0.11 11.4 0.3 1.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF815 PF05673.13 EEA20740.1 - 0.14 11.3 0.1 2.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) KAP_NTPase PF07693.14 EEA20740.1 - 0.18 11.0 0.6 28 3.8 0.0 3.1 3 0 0 3 3 3 0 KAP family P-loop domain Carn_acyltransf PF00755.20 EEA20741.1 - 3.6e-98 329.7 0.0 5.3e-98 329.1 0.0 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase ketoacyl-synt PF00109.26 EEA20741.1 - 9.5e-71 238.3 0.0 2.1e-70 237.2 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EEA20741.1 - 1.2e-55 189.2 0.1 2.4e-55 188.3 0.1 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EEA20741.1 - 2.8e-50 170.7 0.1 1e-49 168.9 0.1 2.1 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EEA20741.1 - 4.9e-38 131.1 0.1 8.6e-38 130.2 0.1 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EEA20741.1 - 1.3e-20 73.6 0.6 5.5e-16 58.6 0.0 3.2 2 1 1 3 3 3 2 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 EEA20741.1 - 4.4e-18 66.6 0.0 2.7e-16 60.8 0.0 3.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 EEA20741.1 - 7e-17 62.0 0.0 3.8e-16 59.6 0.0 2.5 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EEA20741.1 - 1.2e-16 60.9 0.1 7.2e-16 58.4 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EEA20741.1 - 1.8e-14 54.1 0.0 4.4e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EEA20741.1 - 2.9e-12 46.4 0.0 2.6e-11 43.3 0.1 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_25 PF13649.6 EEA20741.1 - 1.6e-10 41.6 0.0 2.4e-09 37.8 0.0 3.2 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA20741.1 - 4.9e-10 39.9 0.0 7.1e-09 36.2 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA20741.1 - 4.4e-09 36.3 0.0 1.3e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EEA20741.1 - 6.6e-07 29.6 0.0 1.7e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EEA20741.1 - 7.4e-07 29.0 0.0 2.4e-06 27.3 0.0 1.9 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 EEA20741.1 - 1.1e-06 28.2 0.0 6.6e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EEA20741.1 - 3.5e-06 27.0 0.0 1.1e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain DUF4113 PF13438.6 EEA20741.1 - 0.01 15.9 0.0 0.037 14.1 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4113) Rtf2 PF04641.12 EEA20741.1 - 0.15 11.4 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger Zn_clus PF00172.18 EEA20742.1 - 7e-10 38.9 5.7 7e-10 38.9 5.7 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA20742.1 - 4.2e-06 26.0 0.7 8.6e-06 25.0 0.7 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gryzun PF07919.12 EEA20743.1 - 2.9e-234 779.3 0.0 3.6e-234 779.0 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 EEA20743.1 - 2.9e-93 312.2 8.8 2.9e-84 282.7 7.6 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 TPR_19 PF14559.6 EEA20743.1 - 0.092 13.3 0.1 2.4 8.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat RXT2_N PF08595.11 EEA20744.1 - 2e-40 138.3 0.0 2e-40 138.3 0.0 3.1 2 1 1 3 3 3 1 RXT2-like, N-terminal PEMT PF04191.13 EEA20745.1 - 1.7e-34 118.4 3.9 3.8e-33 114.0 3.0 2.3 2 0 0 2 2 2 1 Phospholipid methyltransferase EPV_E5 PF08135.11 EEA20745.1 - 0.058 13.8 1.0 0.16 12.3 1.0 1.7 1 0 0 1 1 1 0 Major transforming protein E5 family DUF1223 PF06764.11 EEA20745.1 - 0.059 13.4 0.0 0.081 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) PXA PF02194.15 EEA20746.1 - 8.4e-49 166.0 1.2 3.8e-48 163.9 1.1 2.2 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EEA20746.1 - 5.2e-24 85.0 0.0 2.7e-23 82.7 0.0 2.4 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EEA20746.1 - 1.2e-19 70.4 1.2 2.7e-19 69.2 0.4 2.0 2 0 0 2 2 2 1 PX domain RGS PF00615.19 EEA20746.1 - 5e-13 49.4 0.2 2.3e-12 47.2 0.2 2.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain LRR19-TM PF15176.6 EEA20746.1 - 0.002 18.1 1.0 0.22 11.5 0.1 3.1 3 0 0 3 3 3 1 Leucine-rich repeat family 19 TM domain Mod_r PF07200.13 EEA20746.1 - 0.061 13.4 4.1 1.4 9.1 1.4 3.6 4 0 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein ABC_tran_CTD PF16326.5 EEA20746.1 - 5.3 7.4 11.0 0.74 10.1 5.0 2.8 2 0 0 2 2 2 0 ABC transporter C-terminal domain Glutaredoxin PF00462.24 EEA20747.1 - 1.7e-13 50.6 0.0 3.9e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin Conotoxin PF02950.17 EEA20747.1 - 0.027 15.5 0.8 0.22 12.5 0.0 2.6 2 1 0 2 2 2 0 Conotoxin PBP_sp32 PF07222.12 EEA20747.1 - 0.039 13.4 5.7 0.06 12.8 5.7 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4551 PF15087.6 EEA20747.1 - 0.082 11.7 4.2 0.099 11.5 4.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF680 PF05079.12 EEA20747.1 - 0.19 12.4 0.2 0.19 12.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF680) TraF PF13728.6 EEA20747.1 - 0.35 10.6 2.2 0.49 10.2 0.1 2.1 1 1 1 2 2 2 0 F plasmid transfer operon protein Ribosomal_L6 PF00347.23 EEA20748.1 - 3.3e-23 82.1 3.8 6.7e-11 42.7 0.4 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF3336 PF11815.8 EEA20749.1 - 1.3e-34 118.8 0.1 2.7e-34 117.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EEA20749.1 - 1.3e-15 58.1 0.4 3.3e-15 56.8 0.1 1.8 2 0 0 2 2 2 1 Patatin-like phospholipase Gly-zipper_YMGG PF13441.6 EEA20749.1 - 0.048 13.4 0.5 0.096 12.4 0.5 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper PhoD PF09423.10 EEA20750.1 - 4.1e-05 22.8 2.3 0.00056 19.0 0.2 2.3 3 0 0 3 3 3 2 PhoD-like phosphatase Fungal_trans_2 PF11951.8 EEA20751.1 - 7.4e-40 136.9 0.5 1e-39 136.5 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20751.1 - 6.5e-05 23.0 11.1 0.00015 21.8 11.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAP1 PF08601.10 EEA20751.1 - 0.46 10.1 4.0 0.67 9.6 4.0 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 AA_permease_2 PF13520.6 EEA20752.1 - 3.6e-47 161.2 48.7 4.5e-47 160.8 48.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA20752.1 - 1e-24 87.0 44.2 1.4e-24 86.6 44.2 1.0 1 0 0 1 1 1 1 Amino acid permease Rhomboid PF01694.22 EEA20753.1 - 2.4e-24 86.0 6.3 2.4e-24 86.0 6.3 1.7 2 0 0 2 2 2 1 Rhomboid family Myb_DNA-binding PF00249.31 EEA20753.1 - 0.033 14.4 0.5 0.089 13.0 0.5 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Shugoshin_N PF07558.11 EEA20754.1 - 0.0023 17.8 0.8 0.0044 16.9 0.8 1.4 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DUF4618 PF15397.6 EEA20754.1 - 0.14 11.5 1.9 8.5 5.7 0.3 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) Mob1_phocein PF03637.17 EEA20755.1 - 1.7e-50 171.3 0.0 1.4e-49 168.4 0.0 2.0 1 1 0 1 1 1 1 Mob1/phocein family Leo1 PF04004.13 EEA20756.1 - 2.8e-27 95.6 0.0 1.5e-26 93.2 0.0 2.1 1 1 0 1 1 1 1 Leo1-like protein Caf4 PF11615.8 EEA20756.1 - 0.056 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 CCR4-associated factor 4 Zn_clus PF00172.18 EEA20757.1 - 6e-08 32.7 7.1 6e-08 32.7 7.1 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PADR1 PF08063.12 EEA20757.1 - 0.14 12.0 3.8 0.4 10.5 3.8 1.8 1 0 0 1 1 1 0 PADR1 (NUC008) domain RF-1 PF00472.20 EEA20758.1 - 2e-18 66.4 1.1 2.9e-18 65.9 1.1 1.2 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.9 EEA20758.1 - 0.038 14.4 0.7 0.07 13.5 0.7 1.5 1 1 0 1 1 1 0 Mitochondrial ribosomal subunit protein U3_assoc_6 PF08640.11 EEA20759.1 - 1.6e-28 98.5 2.1 3.1e-28 97.7 0.7 2.1 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EEA20759.1 - 8e-07 29.4 1.7 0.0016 19.1 0.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat NRDE-2 PF08424.10 EEA20759.1 - 0.0037 16.4 0.0 0.0065 15.6 0.0 1.4 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference DUF1351 PF07083.11 EEA20759.1 - 0.041 13.6 0.2 0.095 12.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) Suf PF05843.14 EEA20759.1 - 0.068 13.1 0.6 0.068 13.1 0.6 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Frag1 PF10277.9 EEA20760.1 - 1.8e-37 129.0 6.5 1.8e-37 129.0 6.5 2.8 3 0 0 3 3 3 1 Frag1/DRAM/Sfk1 family Fungal_trans_2 PF11951.8 EEA20761.1 - 2.4e-67 227.4 0.1 3e-67 227.1 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20761.1 - 2.5e-09 37.1 10.4 3.8e-09 36.5 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FinO_N PF12602.8 EEA20761.1 - 0.12 12.7 0.4 0.27 11.6 0.4 1.5 1 0 0 1 1 1 0 Fertility inhibition protein N terminal AT_hook PF02178.19 EEA20761.1 - 0.43 10.6 6.8 1.3 9.2 6.8 1.9 1 0 0 1 1 1 0 AT hook motif MFS_1 PF07690.16 EEA20762.1 - 3.2e-38 131.6 52.7 3.5e-36 124.9 33.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CDH-cyt PF16010.5 EEA20763.1 - 3.4e-17 62.7 0.9 3.4e-17 62.7 0.9 1.5 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase Lactamase_B_6 PF16661.5 EEA20765.1 - 2.7e-64 216.2 0.0 6.9e-64 214.8 0.0 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EEA20765.1 - 2.8e-46 157.8 0.1 2.8e-46 157.8 0.1 2.2 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EEA20765.1 - 5.3e-14 52.5 0.0 1.6e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EEA20765.1 - 4.8e-11 42.4 0.0 1.2e-10 41.2 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EEA20765.1 - 0.02 14.9 0.1 0.061 13.3 0.1 1.8 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA20765.1 - 0.067 12.7 0.1 0.44 10.0 0.0 2.0 1 1 0 2 2 2 0 Beta-lactamase superfamily domain Ank_2 PF12796.7 EEA20766.1 - 2.2e-14 53.8 0.0 2.5e-08 34.4 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA20766.1 - 1.1e-12 48.2 0.0 0.00013 22.4 0.0 5.8 4 2 2 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA20766.1 - 4.6e-12 45.0 0.0 0.087 13.4 0.0 7.0 6 1 1 7 7 7 3 Ankyrin repeat Ank PF00023.30 EEA20766.1 - 1.2e-09 38.1 0.2 1.4 9.5 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EEA20766.1 - 2.8e-08 33.8 0.3 0.33 11.3 0.0 6.2 5 2 2 7 7 7 2 Ankyrin repeats (many copies) Gti1_Pac2 PF09729.9 EEA20768.1 - 3.2e-45 154.4 0.5 8.8e-38 130.2 0.1 2.1 1 1 1 2 2 2 2 Gti1/Pac2 family LTP_2 PF14368.6 EEA20769.1 - 0.037 14.1 2.2 0.037 14.1 2.2 1.5 1 1 0 1 1 1 0 Probable lipid transfer FMN_red PF03358.15 EEA20770.1 - 2.3e-08 33.9 0.0 3e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EEA20770.1 - 0.00011 22.0 0.0 0.00013 21.8 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EEA20770.1 - 0.00081 19.6 0.0 0.056 13.7 0.0 2.3 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EEA20770.1 - 0.057 13.6 0.0 0.11 12.8 0.0 1.4 1 1 0 1 1 1 0 Flavodoxin domain AA_permease_2 PF13520.6 EEA20771.1 - 1.9e-64 218.1 44.7 2.2e-64 217.8 44.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA20771.1 - 1.3e-22 80.1 38.8 1.7e-22 79.7 38.8 1.1 1 0 0 1 1 1 1 Amino acid permease Renin_r PF07850.14 EEA20771.1 - 0.077 13.6 0.1 0.38 11.4 0.1 2.3 1 1 0 1 1 1 0 Renin receptor-like protein DUF2721 PF11026.8 EEA20771.1 - 0.86 9.5 0.0 0.86 9.5 0.0 4.1 4 1 0 4 4 4 0 Protein of unknown function (DUF2721) Sec23_trunk PF04811.15 EEA20772.1 - 3.7e-47 160.9 0.0 7.8e-47 159.9 0.0 1.5 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EEA20772.1 - 4.9e-25 87.3 0.0 1.5e-24 85.8 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EEA20772.1 - 8.8e-18 64.8 0.0 2.2e-17 63.5 0.0 1.7 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EEA20772.1 - 2.4e-16 59.5 6.2 6e-16 58.2 6.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EEA20772.1 - 9.2e-06 25.5 0.0 2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat tRNA-synt_2 PF00152.20 EEA20774.1 - 6.9e-68 229.0 0.0 2.5e-65 220.6 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA20774.1 - 1.7e-06 27.9 0.0 3.1e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RRM_1 PF00076.22 EEA20775.1 - 3.8e-09 36.2 0.0 8.1e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ApoLp-III PF07464.11 EEA20775.1 - 0.031 14.4 0.3 0.031 14.4 0.3 2.5 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF1664 PF07889.12 EEA20775.1 - 0.098 12.7 0.1 0.29 11.2 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) MOZ_SAS PF01853.18 EEA20776.1 - 8.8e-62 207.9 0.0 2e-61 206.8 0.0 1.6 2 0 0 2 2 2 1 MOZ/SAS family zf-MYST PF17772.1 EEA20776.1 - 2.6e-17 62.2 0.7 5e-17 61.3 0.7 1.4 1 0 0 1 1 1 1 MYST family zinc finger domain IF2_N PF04760.15 EEA20776.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Cpn60_TCP1 PF00118.24 EEA20777.1 - 3.3e-164 547.2 0.9 3.7e-164 547.0 0.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_UL6 PF01763.16 EEA20777.1 - 0.17 10.3 0.0 0.26 9.8 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like Cpn60_TCP1 PF00118.24 EEA20778.1 - 1.2e-156 522.2 0.7 1.4e-156 522.0 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_UL6 PF01763.16 EEA20778.1 - 0.15 10.5 0.0 0.23 10.0 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like Nop PF01798.18 EEA20779.1 - 1.5e-88 296.1 0.0 1.5e-88 296.1 0.0 1.5 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EEA20779.1 - 1.4e-19 70.2 0.2 1.4e-19 70.2 0.2 2.2 2 0 0 2 2 2 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 EEA20779.1 - 0.042 13.9 34.4 0.067 13.3 34.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 YL1 PF05764.13 EEA20779.1 - 0.44 10.6 24.1 0.63 10.1 24.1 1.2 1 0 0 1 1 1 0 YL1 nuclear protein GAGA_bind PF06217.12 EEA20779.1 - 2.5 8.3 12.5 5.5 7.2 12.5 1.6 1 0 0 1 1 1 0 GAGA binding protein-like family EIIBC-GUT_N PF03612.14 EEA20779.1 - 4.9 6.9 7.2 9.3 5.9 7.2 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CobT PF06213.12 EEA20779.1 - 8.8 5.6 22.7 1.1 8.6 17.9 2.0 3 0 0 3 3 3 0 Cobalamin biosynthesis protein CobT RP-C_C PF11800.8 EEA20779.1 - 9.9 6.2 8.5 48 3.9 0.0 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region U1snRNP70_N PF12220.8 EEA20780.1 - 7.5 7.3 8.2 20 5.9 7.7 2.1 1 1 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3767 PF12597.8 EEA20781.1 - 1.2e-36 124.5 0.0 1.8e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) 5TM-5TMR_LYT PF07694.12 EEA20781.1 - 0.13 11.8 0.8 0.17 11.4 0.8 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT DUF4718 PF15842.5 EEA20781.1 - 3.5 7.4 5.9 13 5.5 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4718) Nop53 PF07767.11 EEA20781.1 - 5.6 6.3 10.9 3.8 6.8 0.1 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) DUF1744 PF08490.12 EEA20782.1 - 1.6e-150 501.2 0.0 2.2e-150 500.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EEA20782.1 - 6.3e-83 278.7 0.2 7.3e-82 275.2 0.1 2.3 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EEA20782.1 - 1.6e-14 53.5 0.0 1.4e-11 43.8 0.0 3.4 3 1 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EEA20782.1 - 1e-08 35.2 0.1 2.5e-08 33.9 0.1 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EEA20782.1 - 4.5e-05 23.5 0.0 0.00021 21.3 0.0 2.2 1 0 0 1 1 1 1 RNase_H superfamily Pkinase PF00069.25 EEA20783.1 - 5.7e-75 252.1 0.0 7.5e-75 251.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20783.1 - 4.3e-30 104.9 0.0 6e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA20783.1 - 6.2e-08 32.3 0.0 9.6e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA20783.1 - 9.8e-05 21.3 0.0 0.00018 20.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EEA20783.1 - 0.00015 21.2 0.0 0.00029 20.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA20783.1 - 0.00027 20.9 0.0 0.00043 20.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family SEN1_N PF12726.7 EEA20783.1 - 0.065 11.4 0.0 0.087 11.0 0.0 1.1 1 0 0 1 1 1 0 SEN1 N terminal AMMECR1 PF01871.17 EEA20784.1 - 4.4e-41 140.3 0.0 9.8e-41 139.1 0.0 1.5 2 0 0 2 2 2 1 AMMECR1 SGT1 PF07093.11 EEA20785.1 - 1.4e-98 330.9 17.0 8.7e-89 298.5 0.0 2.0 1 1 1 2 2 2 2 SGT1 protein eIF-1a PF01176.19 EEA20785.1 - 0.18 11.6 0.2 0.46 10.3 0.2 1.6 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 GlutR_dimer PF00745.20 EEA20785.1 - 1.4 9.4 4.0 0.99 9.9 0.3 2.6 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain Cnn_1N PF07989.11 EEA20786.1 - 2e-24 85.5 4.5 2e-24 85.5 4.5 15.1 2 1 10 13 13 13 2 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 EEA20786.1 - 4.7e-22 78.4 1.5 4.7e-22 78.4 1.5 3.5 2 0 0 2 2 2 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein TMF_TATA_bd PF12325.8 EEA20786.1 - 8.3e-05 22.8 9.6 8.3e-05 22.8 9.6 12.0 4 3 6 12 12 12 3 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 EEA20786.1 - 0.00023 21.7 168.9 0.17 12.3 28.1 8.2 2 1 6 8 8 8 5 Fez1 TAF8_C PF10406.9 EEA20786.1 - 0.41 11.2 3.0 8.5 7.0 3.0 3.6 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term DUF150 PF02576.17 EEA20786.1 - 8.4 6.9 6.6 1.4 9.4 0.6 2.8 2 0 0 2 2 2 0 RimP N-terminal domain zinc_ribbon_6 PF14599.6 EEA20787.1 - 1.7e-24 85.6 0.3 1.7e-24 85.6 0.3 3.3 3 0 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.12 EEA20787.1 - 7.6e-20 71.2 18.0 7.6e-20 71.2 18.0 3.7 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 EEA20787.1 - 1.8e-08 34.6 7.2 1.8e-08 34.6 7.2 4.8 2 2 4 6 6 6 1 Ring finger domain zf-RING_5 PF14634.6 EEA20787.1 - 8.8e-06 25.6 6.8 8.8e-06 25.6 6.8 6.0 4 2 2 6 6 6 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EEA20787.1 - 2.7e-05 23.9 5.6 2.7e-05 23.9 5.6 4.4 3 1 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EEA20787.1 - 9.3e-05 22.3 3.6 9.3e-05 22.3 3.6 5.4 3 3 3 6 6 6 1 Prokaryotic RING finger family 1 zf-RING_UBOX PF13445.6 EEA20787.1 - 0.00026 21.0 6.8 0.00026 21.0 6.8 2.9 2 0 0 2 2 2 1 RING-type zinc-finger DUF2293 PF10056.9 EEA20788.1 - 6.8e-31 106.4 0.2 1.4e-30 105.4 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) HMA PF00403.26 EEA20789.1 - 5e-17 62.1 0.9 5.8e-17 61.9 0.9 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Fer2_BFD PF04324.15 EEA20789.1 - 0.059 13.7 0.1 0.15 12.4 0.0 1.7 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain GnsAB_toxin PF08178.11 EEA20789.1 - 0.16 12.0 0.7 2.2 8.2 0.2 2.1 2 0 0 2 2 2 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system Rrn6 PF10214.9 EEA20790.1 - 2.1e-205 684.9 0.6 2.4e-205 684.7 0.6 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Spindle_Spc25 PF08234.12 EEA20791.1 - 5.9e-21 74.5 0.0 1.8e-20 72.9 0.0 1.9 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Filament PF00038.21 EEA20791.1 - 0.0018 18.0 9.4 0.0035 17.0 9.4 1.5 1 0 0 1 1 1 1 Intermediate filament protein Polysacc_deac_1 PF01522.21 EEA20791.1 - 0.032 14.1 0.9 0.057 13.3 0.9 1.4 1 0 0 1 1 1 0 Polysaccharide deacetylase DUF4407 PF14362.6 EEA20791.1 - 0.12 11.7 7.7 0.21 10.9 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RILP PF11461.8 EEA20791.1 - 0.17 12.2 1.7 0.3 11.3 0.2 2.1 2 0 0 2 2 2 0 Rab interacting lysosomal protein Atg14 PF10186.9 EEA20791.1 - 1.4 8.0 9.2 2.1 7.3 9.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BRE1 PF08647.11 EEA20791.1 - 3.9 7.6 14.3 1.1 9.4 10.8 1.9 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase WD40 PF00400.32 EEA20792.1 - 1.9e-20 72.8 9.3 3.6e-07 30.8 0.5 6.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20792.1 - 3.4e-16 59.3 0.5 0.0051 17.1 0.0 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA20792.1 - 6.4e-06 26.2 0.1 0.0046 16.9 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EEA20792.1 - 0.0002 20.8 0.0 0.16 11.2 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 EEA20792.1 - 0.00034 19.4 0.1 0.039 12.6 0.1 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EEA20792.1 - 0.0006 18.5 0.1 0.079 11.5 0.0 2.0 1 1 0 2 2 2 2 Cytochrome D1 heme domain VID27 PF08553.10 EEA20792.1 - 0.0064 15.6 0.0 0.051 12.6 0.0 2.1 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain Coatomer_WDAD PF04053.14 EEA20792.1 - 0.035 13.2 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region Asp_decarbox PF02261.16 EEA20792.1 - 0.15 12.0 0.0 4.1 7.4 0.0 2.6 2 1 1 3 3 3 0 Aspartate decarboxylase WD40 PF00400.32 EEA20793.1 - 4.2e-22 78.0 4.1 2.2e-07 31.5 0.5 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20793.1 - 7.8e-17 61.4 0.5 0.00012 22.3 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA20793.1 - 3.3e-06 27.1 0.0 0.0025 17.7 0.0 2.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EEA20793.1 - 0.00012 21.6 0.0 0.17 11.2 0.0 2.1 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 EEA20793.1 - 0.00017 20.4 0.1 0.025 13.2 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EEA20793.1 - 0.00021 20.0 0.0 0.043 12.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome D1 heme domain VID27 PF08553.10 EEA20793.1 - 0.0039 16.3 0.0 0.026 13.6 0.0 2.0 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain Coatomer_WDAD PF04053.14 EEA20793.1 - 0.018 14.1 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region Gmad1 PF10647.9 EEA20793.1 - 0.051 13.3 0.1 0.13 12.0 0.2 1.6 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Hira PF07569.11 EEA20793.1 - 0.17 11.6 1.5 9.6 5.9 0.0 2.3 3 0 0 3 3 3 0 TUP1-like enhancer of split WD40 PF00400.32 EEA20794.1 - 4.7e-22 77.9 4.3 2.2e-07 31.5 0.5 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20794.1 - 7.6e-17 61.4 0.6 0.0035 17.6 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA20794.1 - 2.5e-06 27.5 0.0 0.0025 17.7 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EEA20794.1 - 3.6e-05 23.2 0.0 0.048 13.0 0.0 2.1 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 EEA20794.1 - 0.00012 20.9 0.1 0.024 13.3 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EEA20794.1 - 0.0002 20.0 0.0 0.042 12.4 0.0 2.0 2 0 0 2 2 2 2 Cytochrome D1 heme domain VID27 PF08553.10 EEA20794.1 - 0.0023 17.1 0.0 0.027 13.5 0.0 2.0 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain Coatomer_WDAD PF04053.14 EEA20794.1 - 0.015 14.3 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region Gmad1 PF10647.9 EEA20794.1 - 0.05 13.4 0.1 0.13 12.0 0.2 1.6 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Hira PF07569.11 EEA20794.1 - 0.16 11.6 1.5 9.5 5.9 0.0 2.3 3 0 0 3 3 3 0 TUP1-like enhancer of split Septin PF00735.18 EEA20795.1 - 5.9e-114 380.1 1.5 7e-114 379.9 1.5 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EEA20795.1 - 3.5e-08 33.5 0.0 7.4e-08 32.5 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EEA20795.1 - 1.1e-05 24.9 0.0 1.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 EEA20795.1 - 3.5e-05 23.4 1.4 0.023 14.3 0.1 2.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA20795.1 - 5.8e-05 23.1 0.8 0.00046 20.1 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EEA20795.1 - 0.00057 20.0 1.6 0.81 9.7 0.2 2.6 2 1 1 3 3 3 2 Dynamin family AAA_7 PF12775.7 EEA20795.1 - 0.00069 19.2 0.1 0.0042 16.6 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region NB-ARC PF00931.22 EEA20795.1 - 0.0023 17.1 0.1 0.0042 16.3 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EEA20795.1 - 0.0049 17.3 0.0 0.013 15.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 EEA20795.1 - 0.0092 15.4 0.1 0.33 10.3 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 EEA20795.1 - 0.012 16.2 1.0 0.018 15.5 0.2 1.7 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 EEA20795.1 - 0.013 15.8 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EEA20795.1 - 0.04 14.1 0.0 0.081 13.1 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EEA20795.1 - 0.058 12.6 1.4 0.25 10.5 1.0 1.8 1 1 0 1 1 1 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 EEA20795.1 - 0.067 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 EEA20795.1 - 0.15 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Guanylate_kin PF00625.21 EEA20796.1 - 6.1e-65 218.3 0.0 7.4e-65 218.0 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EEA20796.1 - 3.3e-06 27.6 0.4 1.2e-05 25.8 0.4 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EEA20796.1 - 1.2e-05 25.5 0.2 0.0001 22.5 0.2 2.2 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EEA20796.1 - 2.3e-05 24.5 0.0 3.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EEA20796.1 - 2.8e-05 24.7 0.6 0.00011 22.7 0.3 2.1 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA20796.1 - 0.0002 21.7 0.0 0.00054 20.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EEA20796.1 - 0.00033 21.2 0.0 0.00051 20.6 0.0 1.7 1 1 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 EEA20796.1 - 0.00052 20.3 0.0 0.00091 19.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EEA20796.1 - 0.0013 18.6 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_24 PF13479.6 EEA20796.1 - 0.0015 18.3 0.2 0.018 14.8 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EEA20796.1 - 0.002 17.7 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EEA20796.1 - 0.0025 18.2 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase T2SSE PF00437.20 EEA20796.1 - 0.0035 16.5 0.0 0.0059 15.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 EEA20796.1 - 0.007 16.4 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EEA20796.1 - 0.0074 16.2 0.0 0.016 15.1 0.0 1.6 1 1 0 1 1 1 1 NTPase NACHT PF05729.12 EEA20796.1 - 0.008 16.1 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_29 PF13555.6 EEA20796.1 - 0.0081 15.9 0.1 0.015 15.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 EEA20796.1 - 0.0094 16.4 0.0 0.027 14.9 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EEA20796.1 - 0.011 15.0 0.0 0.12 11.6 0.0 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EEA20796.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 EEA20796.1 - 0.012 15.6 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 EEA20796.1 - 0.022 14.7 0.0 0.031 14.2 0.0 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EEA20796.1 - 0.027 14.5 0.1 0.14 12.2 0.0 2.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EEA20796.1 - 0.043 14.3 0.1 0.24 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EEA20796.1 - 0.092 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 EEA20796.1 - 0.096 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein cobW PF02492.19 EEA20796.1 - 0.11 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain dNK PF01712.19 EEA20796.1 - 0.16 11.8 0.3 1.5 8.6 0.0 2.3 2 1 0 2 2 2 0 Deoxynucleoside kinase GRAB PF10375.9 EEA20797.1 - 1.7e-08 34.0 0.1 1.7e-08 34.0 0.1 2.3 2 0 0 2 2 2 1 GRIP-related Arf-binding domain TPR_MLP1_2 PF07926.12 EEA20797.1 - 0.0018 18.3 81.4 0.17 11.9 16.7 5.1 1 1 2 4 4 4 4 TPR/MLP1/MLP2-like protein SIKE PF05769.11 EEA20797.1 - 0.005 16.8 20.9 0.005 16.8 20.9 3.1 1 1 2 3 3 1 1 SIKE family Apolipoprotein PF01442.18 EEA20797.1 - 0.033 14.1 57.4 0.79 9.6 44.9 2.7 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF948 PF06103.11 EEA20797.1 - 0.053 13.8 23.3 0.85 9.9 0.4 4.9 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) HALZ PF02183.18 EEA20797.1 - 0.062 13.5 0.2 0.062 13.5 0.2 5.5 6 0 0 6 6 4 0 Homeobox associated leucine zipper Baculo_PEP_C PF04513.12 EEA20797.1 - 0.086 12.9 28.5 0.68 10.0 3.7 4.4 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus FH2 PF02181.23 EEA20797.1 - 0.2 10.7 33.8 0.026 13.6 3.9 3.6 1 1 2 3 3 3 0 Formin Homology 2 Domain Prominin PF05478.11 EEA20797.1 - 0.71 7.8 30.4 0.086 10.8 7.8 2.3 1 1 1 2 2 2 0 Prominin DUF1664 PF07889.12 EEA20797.1 - 1.7 8.7 30.5 2.1 8.4 5.2 4.2 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) COG2 PF06148.11 EEA20797.1 - 2.5 8.2 39.7 0.54 10.4 6.7 4.8 1 1 4 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4407 PF14362.6 EEA20797.1 - 3.4 6.9 64.7 0.047 13.0 16.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) TTRAP PF14203.6 EEA20797.1 - 3.9 7.5 9.5 0.78 9.8 0.4 3.7 3 1 0 3 3 3 0 Putative tranposon-transfer assisting protein Golgin_A5 PF09787.9 EEA20797.1 - 4.2 6.8 74.6 0.7 9.3 14.7 3.9 1 1 3 4 4 3 0 Golgin subfamily A member 5 FAM184 PF15665.5 EEA20797.1 - 4.2 7.1 67.1 0.97 9.2 16.3 3.6 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B DUF3800 PF12686.7 EEA20797.1 - 4.4 8.0 6.2 3e+02 2.0 5.5 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) HMMR_N PF15905.5 EEA20797.1 - 6.8 6.1 78.9 0.083 12.4 18.1 3.1 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 EEA20797.1 - 8.9 5.1 73.4 0.21 10.4 32.6 3.5 1 1 3 4 4 4 0 Spc7 kinetochore protein FlaC_arch PF05377.11 EEA20797.1 - 9.4 6.7 35.1 1.8 9.0 0.6 6.6 3 2 3 6 6 6 0 Flagella accessory protein C (FlaC) GRAB PF10375.9 EEA20798.1 - 4.3e-09 35.9 0.1 1.2e-08 34.5 0.1 1.9 1 0 0 1 1 1 1 GRIP-related Arf-binding domain TPR_MLP1_2 PF07926.12 EEA20798.1 - 0.0021 18.1 59.3 0.16 12.1 13.8 3.8 1 1 1 3 3 3 3 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 EEA20798.1 - 0.0062 14.1 44.9 0.0074 13.9 44.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Seryl_tRNA_N PF02403.22 EEA20798.1 - 0.027 14.7 45.4 0.28 11.4 10.7 4.2 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Apolipoprotein PF01442.18 EEA20798.1 - 0.028 14.3 46.5 0.29 11.0 44.8 2.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Spc7 PF08317.11 EEA20798.1 - 0.031 13.2 51.7 0.1 11.4 17.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 EEA20798.1 - 0.037 14.3 18.5 0.55 10.5 0.4 4.3 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Golgin_A5 PF09787.9 EEA20798.1 - 0.12 11.8 51.2 0.35 10.3 14.3 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 Prominin PF05478.11 EEA20798.1 - 0.15 10.0 24.9 0.061 11.3 8.1 2.2 1 1 1 2 2 2 0 Prominin HMMR_N PF15905.5 EEA20798.1 - 0.2 11.1 52.7 0.089 12.2 19.3 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal FAM184 PF15665.5 EEA20798.1 - 0.21 11.4 47.7 0.67 9.7 16.6 2.3 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B DUF4407 PF14362.6 EEA20798.1 - 0.39 10.0 37.8 0.85 8.9 21.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EEA20798.1 - 0.4 10.9 30.1 1.7 8.8 11.2 3.3 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Atg14 PF10186.9 EEA20798.1 - 0.42 9.6 44.2 1.1 8.2 14.3 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Laminin_II PF06009.12 EEA20798.1 - 0.64 10.0 31.9 1.8 8.6 5.0 3.6 1 1 1 3 3 3 0 Laminin Domain II TTRAP PF14203.6 EEA20798.1 - 0.92 9.5 5.2 0.53 10.3 0.4 3.2 3 1 0 3 3 2 0 Putative tranposon-transfer assisting protein BST2 PF16716.5 EEA20798.1 - 1 10.0 43.9 0.082 13.5 10.6 4.3 2 1 3 5 5 5 0 Bone marrow stromal antigen 2 ATG16 PF08614.11 EEA20798.1 - 1.5 9.0 57.5 6.4 6.9 25.1 4.0 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Filament PF00038.21 EEA20798.1 - 1.5 8.3 44.5 1.9 8.0 17.3 2.4 1 1 1 2 2 2 0 Intermediate filament protein Vac_Fusion PF02346.16 EEA20798.1 - 1.6 8.4 5.2 13 5.5 0.0 3.4 3 1 0 4 4 3 0 Chordopoxvirus multifunctional envelope protein A27 Pox_A_type_inc PF04508.12 EEA20798.1 - 1.7 8.6 11.4 1.3 9.0 2.5 3.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat IFT57 PF10498.9 EEA20798.1 - 1.9 7.4 41.7 0.25 10.3 11.4 3.1 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 YtxH PF12732.7 EEA20798.1 - 4 8.0 18.3 6.7 7.3 4.6 4.1 2 2 0 2 2 2 0 YtxH-like protein CorA PF01544.18 EEA20798.1 - 4.2 6.6 29.6 3.3 6.9 16.5 2.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein LMP PF04778.12 EEA20798.1 - 4.4 7.2 32.8 0.66 9.9 6.6 4.2 1 1 3 4 4 4 0 LMP repeated region FH2 PF02181.23 EEA20798.1 - 4.4 6.3 30.0 0.014 14.5 3.8 3.2 1 1 2 3 3 3 0 Formin Homology 2 Domain EzrA PF06160.12 EEA20798.1 - 5.8 5.0 39.7 62 1.6 39.7 2.1 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA XhlA PF10779.9 EEA20798.1 - 5.9 7.2 33.6 0.38 11.0 3.9 4.9 3 1 1 5 5 5 0 Haemolysin XhlA FlaC_arch PF05377.11 EEA20798.1 - 8.7 6.8 31.1 1.2 9.6 0.6 5.7 3 2 3 6 6 5 0 Flagella accessory protein C (FlaC) VWA_2 PF13519.6 EEA20798.1 - 8.8 7.0 9.2 3.5 8.3 1.1 3.7 1 1 2 3 3 3 0 von Willebrand factor type A domain Fez1 PF06818.15 EEA20798.1 - 9 6.7 47.9 2.8 8.4 12.7 3.2 1 1 2 3 3 3 0 Fez1 NFACT-R_1 PF05670.13 EEA20799.1 - 3.3e-32 111.4 0.1 9.5e-32 109.9 0.1 1.8 1 1 0 1 1 1 1 NFACT protein RNA binding domain TBCC PF07986.12 EEA20799.1 - 0.0049 16.6 0.0 0.0093 15.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C NARP1 PF12569.8 EEA20799.1 - 0.032 13.1 8.0 0.04 12.8 8.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 LMBR1 PF04791.16 EEA20799.1 - 5.6 5.7 4.5 6.4 5.6 4.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DAO PF01266.24 EEA20800.1 - 8.2e-50 170.3 0.0 1.2e-49 169.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EEA20800.1 - 1.5e-44 150.9 0.0 2.6e-44 150.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EEA20800.1 - 1.4e-08 34.2 0.0 2.8e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EEA20800.1 - 0.0003 20.3 0.3 0.00054 19.4 0.1 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA20800.1 - 0.0018 17.6 0.0 0.0033 16.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA20800.1 - 0.0062 16.7 0.5 0.017 15.3 0.3 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 EEA20800.1 - 0.013 15.4 0.2 0.026 14.4 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EEA20800.1 - 0.036 12.8 0.3 0.063 12.0 0.3 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EEA20800.1 - 0.063 13.8 0.2 0.17 12.5 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA20800.1 - 0.091 12.0 0.1 0.23 10.7 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA20800.1 - 0.091 11.8 0.1 0.2 10.7 0.1 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Ecl1 PF12855.7 EEA20801.1 - 1.1e-11 46.3 28.4 2e-11 45.4 28.4 1.4 1 1 0 1 1 1 1 ECL1/2/3 zinc binding proteins YacG PF03884.14 EEA20801.1 - 0.0042 16.8 0.3 0.0081 15.9 0.3 1.4 1 0 0 1 1 1 1 DNA gyrase inhibitor YacG MciZ PF13072.6 EEA20801.1 - 0.079 12.8 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 Mother cell inhibitor of FtsZ DUF515 PF04415.12 EEA20801.1 - 5.7 5.2 20.5 7 4.9 20.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DASH_Dad2 PF08654.10 EEA20802.1 - 3.7e-26 91.4 5.7 1e-25 90.0 5.7 1.7 1 1 0 1 1 1 1 DASH complex subunit Dad2 CENP-F_leu_zip PF10473.9 EEA20802.1 - 0.032 14.2 1.9 0.04 13.9 1.9 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PAXX PF15384.6 EEA20802.1 - 0.058 13.1 1.5 0.067 12.9 1.5 1.2 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 CAMSAP_CC1 PF17095.5 EEA20802.1 - 0.21 11.5 2.7 5.6 6.9 0.1 2.3 1 1 1 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin NPV_P10 PF05531.12 EEA20802.1 - 0.59 10.6 3.7 7.9 7.0 1.0 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein ABC_tran_CTD PF16326.5 EEA20802.1 - 0.68 10.2 5.6 0.91 9.8 0.6 2.4 1 1 2 3 3 3 0 ABC transporter C-terminal domain Shugoshin_N PF07558.11 EEA20803.1 - 1.5e-16 59.9 7.3 3.7e-16 58.7 3.6 2.5 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EEA20803.1 - 1.5e-10 40.6 4.6 1.5e-10 40.6 4.6 2.5 2 0 0 2 2 2 1 Shugoshin C terminus CCDC85 PF10226.9 EEA20803.1 - 0.019 14.7 0.5 0.067 12.9 0.5 1.9 1 0 0 1 1 1 0 CCDC85 family Prok-TraM PF09228.10 EEA20803.1 - 0.02 15.2 0.2 0.055 13.8 0.2 1.8 1 0 0 1 1 1 0 Prokaryotic Transcriptional repressor TraM bZIP_2 PF07716.15 EEA20803.1 - 0.14 12.2 2.6 0.15 12.2 0.4 2.2 2 0 0 2 2 2 0 Basic region leucine zipper Mod_r PF07200.13 EEA20803.1 - 0.18 11.9 4.0 0.65 10.1 3.9 2.1 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein HALZ PF02183.18 EEA20803.1 - 0.38 11.0 3.7 1.3 9.3 1.0 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper DivIC PF04977.15 EEA20803.1 - 1.8 8.4 3.4 2.1 8.2 1.0 2.4 1 1 1 2 2 2 0 Septum formation initiator PPI_Ypi1 PF07491.11 EEA20804.1 - 4.3e-25 87.3 5.0 1.3e-24 85.8 5.0 1.9 1 1 0 1 1 1 1 Protein phosphatase inhibitor CDC45 PF02724.14 EEA20804.1 - 0.3 9.3 10.3 0.29 9.4 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 EEA20804.1 - 0.65 8.5 13.1 0.82 8.2 13.0 1.3 1 1 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CRM1_C PF08767.11 EEA20805.1 - 1.6e-138 461.3 8.9 1.6e-138 461.3 8.9 3.0 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EEA20805.1 - 1.9e-42 144.8 10.7 2.2e-41 141.4 6.4 3.9 3 1 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EEA20805.1 - 8e-34 115.1 4.5 2e-33 113.9 3.6 2.3 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EEA20805.1 - 3.3e-29 100.7 0.6 3.3e-29 100.7 0.6 2.7 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EEA20805.1 - 2.5e-20 71.7 1.8 5.5e-20 70.6 1.8 1.6 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EEA20805.1 - 4.8e-12 45.6 0.1 2.1e-11 43.5 0.1 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF3385 PF11865.8 EEA20805.1 - 0.016 15.1 5.8 0.09 12.7 0.0 4.3 5 1 1 6 6 6 0 Domain of unknown function (DUF3385) HD_assoc PF13286.6 EEA20805.1 - 0.15 12.6 2.9 25 5.5 0.2 4.0 4 0 0 4 4 4 0 Phosphohydrolase-associated domain Mac_assoc PF16628.5 EEA20806.1 - 7.2e-85 283.9 10.8 7.2e-85 283.9 10.8 2.1 2 0 0 2 2 2 1 Unstructured region on maltose acetyltransferase Mac PF12464.8 EEA20806.1 - 2.6e-12 46.8 0.0 6.4e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 EEA20806.1 - 2.2e-10 40.1 4.9 1.1e-07 31.5 0.0 3.5 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Zn_clus PF00172.18 EEA20806.1 - 6.9e-10 38.9 8.5 1.5e-09 37.8 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexapep PF00132.24 EEA20806.1 - 1.5e-08 34.0 5.6 0.00033 20.3 0.1 3.7 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) ALAD PF00490.21 EEA20807.1 - 4.6e-121 403.9 0.0 5.5e-121 403.6 0.0 1.1 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase HABP4_PAI-RBP1 PF04774.15 EEA20808.1 - 0.01 16.7 0.5 0.014 16.3 0.5 1.2 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family DUF4300 PF14133.6 EEA20810.1 - 0.018 14.8 0.1 0.025 14.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) HsbA PF12296.8 EEA20810.1 - 0.093 13.2 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 Hydrophobic surface binding protein A zf-RVT PF13966.6 EEA20811.1 - 0.00015 22.4 0.0 0.00027 21.6 0.0 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase DDE_1 PF03184.19 EEA20812.1 - 9.5e-33 113.3 0.0 2e-32 112.2 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA20812.1 - 5e-09 36.1 0.5 2.4e-08 33.9 0.0 2.2 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA20812.1 - 1.1e-05 25.1 0.0 2.8e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_1 PF03184.19 EEA20813.1 - 5.1e-17 62.1 0.0 1.1e-16 61.0 0.0 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA20813.1 - 6.6e-10 38.9 0.0 2.8e-09 36.8 0.0 2.2 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA20813.1 - 0.0077 16.0 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Tup_N PF08581.10 EEA20813.1 - 0.03 14.6 0.6 0.1 13.0 0.6 1.9 1 0 0 1 1 1 0 Tup N-terminal Sds3 PF08598.11 EEA20813.1 - 0.048 13.6 1.0 0.078 13.0 1.0 1.2 1 0 0 1 1 1 0 Sds3-like PknG_rubred PF16919.5 EEA20813.1 - 0.077 13.2 0.9 0.14 12.3 0.9 1.4 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain N-SET PF11764.8 EEA20815.1 - 6.2e-53 179.4 0.0 2e-52 177.8 0.0 2.0 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EEA20815.1 - 4.9e-27 93.4 1.0 1e-26 92.3 0.4 1.9 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated SET PF00856.28 EEA20815.1 - 3.2e-21 76.4 0.3 1.9e-20 73.9 0.2 2.5 2 0 0 2 2 2 1 SET domain RRM_1 PF00076.22 EEA20815.1 - 0.00019 21.1 0.0 0.00042 20.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rad60-SLD PF11976.8 EEA20816.1 - 3.9e-17 61.9 0.1 2.6e-16 59.2 0.1 2.4 3 0 0 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like Trm112p PF03966.16 EEA20816.1 - 1e-10 42.0 0.0 1.4e-09 38.4 0.0 2.8 2 1 0 2 2 2 1 Trm112p-like protein ubiquitin PF00240.23 EEA20816.1 - 0.00022 20.9 0.0 0.00061 19.5 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family LSM PF01423.22 EEA20817.1 - 7.5e-20 70.4 0.0 8.4e-20 70.2 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA20817.1 - 0.0019 18.3 0.0 0.0021 18.1 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EEA20817.1 - 0.014 15.5 0.1 0.016 15.3 0.1 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain Hfq PF17209.3 EEA20817.1 - 0.056 13.1 0.0 0.075 12.7 0.0 1.2 1 0 0 1 1 1 0 Hfq protein IF-2B PF01008.17 EEA20818.1 - 9.2e-73 244.9 1.2 1.1e-72 244.7 1.2 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family SIS PF01380.22 EEA20819.1 - 1.6e-60 202.7 0.1 3e-32 111.2 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EEA20819.1 - 8.6e-17 61.6 0.0 1.7e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EEA20819.1 - 1.8e-10 40.8 0.0 4.3e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EEA20819.1 - 0.0032 16.4 0.0 0.0051 15.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DMRL_synthase PF00885.19 EEA20820.1 - 2.7e-55 186.1 1.3 4.8e-55 185.3 1.3 1.4 1 1 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase GalBD_like PF17974.1 EEA20820.1 - 0.088 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Galactose-binding domain-like Proteasome PF00227.26 EEA20821.1 - 3.4e-45 153.9 0.1 3e-32 111.7 0.0 2.3 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EEA20821.1 - 5.3e-12 45.2 1.0 6.2e-12 45.0 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Zn_Tnp_IS91 PF14319.6 EEA20822.1 - 6.9e-06 26.0 1.3 1.2e-05 25.2 1.3 1.4 1 0 0 1 1 1 1 Transposase zinc-binding domain Lar_restr_allev PF14354.6 EEA20822.1 - 0.0085 16.4 1.0 0.018 15.4 1.0 1.5 1 0 0 1 1 1 1 Restriction alleviation protein Lar GNAT_acetyltran PF12746.7 EEA20822.1 - 0.082 12.5 0.0 0.27 10.8 0.0 1.8 2 0 0 2 2 2 0 GNAT acetyltransferase zinc_ribbon_2 PF13240.6 EEA20822.1 - 0.35 10.7 3.2 4.5 7.1 1.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Iso_dh PF00180.20 EEA20823.1 - 2e-83 280.5 0.0 2.4e-83 280.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase WBS_methylT PF12589.8 EEA20824.1 - 5.4e-14 52.7 3.5 9.1e-14 52.0 3.5 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EEA20824.1 - 4.6e-10 40.0 0.0 8.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA20824.1 - 1.5e-09 38.5 0.0 4.2e-09 37.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA20824.1 - 0.00043 20.1 0.0 0.00067 19.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EEA20824.1 - 0.0025 17.6 0.0 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 EEA20824.1 - 0.0031 18.2 0.0 0.0082 16.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA20824.1 - 0.039 13.3 0.0 0.26 10.6 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EEA20824.1 - 0.16 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EEA20824.1 - 0.2 10.9 0.0 1.4 8.1 0.0 1.9 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Erv26 PF04148.13 EEA20825.1 - 1.7e-93 312.2 0.3 1.9e-93 312.0 0.3 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF1970 PF09301.10 EEA20825.1 - 0.3 11.4 4.2 0.26 11.6 0.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1970) RhoGAP PF00620.27 EEA20826.1 - 3.7e-41 140.5 0.1 7.5e-41 139.5 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EEA20826.1 - 1.4e-13 51.2 0.0 3.1e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 PH domain DUF2353 PF09789.9 EEA20826.1 - 0.048 13.0 2.8 0.085 12.2 2.8 1.3 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) PH_8 PF15409.6 EEA20826.1 - 0.12 12.7 0.0 0.7 10.2 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain MDM31_MDM32 PF08118.11 EEA20827.1 - 3.6e-253 841.0 0.1 4.6e-253 840.7 0.1 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins TraH_2 PF06871.11 EEA20827.1 - 0.0086 15.7 0.4 0.015 15.0 0.4 1.3 1 0 0 1 1 1 1 TraH_2 KH_8 PF17903.1 EEA20828.1 - 4.4e-05 23.5 0.0 8.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EEA20828.1 - 0.0021 17.9 0.5 0.017 14.9 0.3 2.3 2 0 0 2 2 2 1 KH domain Proteasome PF00227.26 EEA20829.1 - 1.5e-30 106.1 0.1 4.5e-30 104.5 0.1 1.8 1 1 0 1 1 1 1 Proteasome subunit HCNGP PF07818.13 EEA20830.1 - 8.1e-28 96.9 0.1 1.4e-27 96.1 0.1 1.4 1 0 0 1 1 1 1 HCNGP-like protein Proteasome PF00227.26 EEA20831.1 - 1.5e-28 99.6 0.0 1.8e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Complex1_LYR PF05347.15 EEA20832.1 - 5.9e-18 64.7 2.1 3e-17 62.4 2.7 1.9 2 0 0 2 2 2 1 Complex 1 protein (LYR family) HSP20 PF00011.21 EEA20832.1 - 3.6e-15 56.0 4.8 7.3e-12 45.3 0.3 3.0 2 1 1 3 3 3 2 Hsp20/alpha crystallin family Complex1_LYR_2 PF13233.6 EEA20832.1 - 6.7e-07 30.0 0.1 1.4e-06 29.0 0.1 1.5 1 0 0 1 1 1 1 Complex1_LYR-like ArsA_HSP20 PF17886.1 EEA20832.1 - 1.8e-06 27.4 0.0 0.00096 18.7 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA Complex1_LYR_1 PF13232.6 EEA20832.1 - 0.092 13.4 0.2 0.21 12.2 0.2 1.6 1 0 0 1 1 1 0 Complex1_LYR-like FAA_hydrolase PF01557.18 EEA20833.1 - 2.1e-63 213.9 0.0 2.7e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2437 PF10370.9 EEA20833.1 - 0.17 12.8 0.2 2.2 9.2 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2437) Autophagy_act_C PF03987.15 EEA20835.1 - 2.8e-11 43.8 0.2 4.9e-11 43.0 0.2 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain RRM_1 PF00076.22 EEA20836.1 - 8e-10 38.4 0.0 2e-09 37.1 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA20836.1 - 5.4e-05 22.8 0.0 7.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA20836.1 - 0.008 16.0 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Prim-Pol PF09250.11 EEA20836.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.5 1 1 0 1 1 1 0 Bifunctional DNA primase/polymerase, N-terminal FSA_C PF10479.9 EEA20836.1 - 0.13 10.3 0.0 0.15 10.1 0.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ribosomal_60s PF00428.19 EEA20836.1 - 2.2 8.9 7.6 6 7.5 7.6 1.8 1 1 0 1 1 1 0 60s Acidic ribosomal protein WD40 PF00400.32 EEA20837.1 - 7.2e-17 61.5 12.1 0.00022 22.0 0.0 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20837.1 - 8.7e-09 35.6 0.0 0.0069 16.7 0.0 4.8 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 EEA20837.1 - 0.0014 18.4 2.1 0.014 15.2 0.1 2.8 2 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF3642 PF12182.8 EEA20837.1 - 0.033 14.5 0.1 2 8.7 0.0 2.5 2 0 0 2 2 2 0 Bacterial lipoprotein DPPIV_N PF00930.21 EEA20837.1 - 0.054 12.2 0.8 6.5 5.4 0.0 3.3 2 1 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ge1_WD40 PF16529.5 EEA20837.1 - 0.15 11.0 0.0 32 3.3 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Lipase_3 PF01764.25 EEA20838.1 - 4.2e-30 104.5 0.0 6.7e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EEA20838.1 - 0.00016 21.1 0.0 0.00033 20.0 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA20838.1 - 0.00068 20.3 0.0 0.0011 19.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 EEA20838.1 - 0.0044 16.6 0.2 0.1 12.2 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 EEA20838.1 - 0.012 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA20838.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 EEA20838.1 - 0.015 15.4 0.0 0.038 14.1 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain DUF676 PF05057.14 EEA20838.1 - 0.051 13.1 0.0 0.099 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Cutinase PF01083.22 EEA20838.1 - 0.068 13.1 0.0 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Cutinase Abhydrolase_8 PF06259.12 EEA20838.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase DrsE PF02635.15 EEA20838.1 - 0.26 11.7 0.8 0.51 10.7 0.1 1.8 2 0 0 2 2 2 0 DsrE/DsrF-like family WW PF00397.26 EEA20839.1 - 3.6e-11 43.0 0.4 7.5e-11 41.9 0.4 1.6 1 0 0 1 1 1 1 WW domain PhoD PF09423.10 EEA20839.1 - 0.053 12.5 0.3 0.12 11.4 0.3 1.5 1 0 0 1 1 1 0 PhoD-like phosphatase Fungal_trans_2 PF11951.8 EEA20840.1 - 3e-17 62.5 4.7 4.3e-17 62.0 4.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20840.1 - 5e-10 39.3 7.0 8.8e-10 38.5 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ecm29 PF13001.7 EEA20841.1 - 2.9e-159 530.9 3.0 5.3e-157 523.5 0.0 3.5 4 1 0 4 4 4 2 Proteasome stabiliser HEAT PF02985.22 EEA20841.1 - 0.00074 19.6 1.4 3.2 8.3 0.1 7.2 8 0 0 8 8 8 1 HEAT repeat Vac14_Fab1_bd PF12755.7 EEA20841.1 - 0.0014 19.1 0.2 2.8 8.6 0.1 4.6 4 1 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EEA20841.1 - 0.0043 17.5 6.1 16 6.2 0.0 7.7 7 1 1 8 8 8 1 HEAT-like repeat SNF2_N PF00176.23 EEA20842.1 - 2.1e-60 204.3 0.0 4.2e-60 203.3 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 EEA20842.1 - 3.1e-07 30.1 14.2 8.6e-07 28.7 14.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA20842.1 - 8.6e-07 28.7 14.2 2.2e-06 27.4 14.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA20842.1 - 1.1e-06 28.4 11.9 2.9e-06 27.0 11.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 EEA20842.1 - 3.4e-06 27.4 0.0 8.5e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 EEA20842.1 - 9.2e-06 25.9 15.6 2.2e-05 24.7 15.6 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EEA20842.1 - 0.00027 20.8 11.6 0.00066 19.5 11.6 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EEA20842.1 - 0.00039 20.4 10.4 0.00098 19.1 10.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger ResIII PF04851.15 EEA20842.1 - 0.00079 19.5 0.0 0.0026 17.8 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-rbx1 PF12678.7 EEA20842.1 - 0.0078 16.5 12.4 0.023 15.0 12.4 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain SWI2_SNF2 PF18766.1 EEA20842.1 - 0.022 14.4 0.0 0.056 13.1 0.0 1.7 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Baculo_IE-1 PF05290.11 EEA20842.1 - 0.023 14.6 1.0 0.06 13.3 1.0 1.7 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_5 PF14634.6 EEA20842.1 - 0.041 13.9 14.0 0.1 12.6 14.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EEA20842.1 - 0.16 12.2 11.7 0.33 11.1 11.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EEA20842.1 - 9.1 6.0 12.7 19 5.0 12.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PNGaseA PF12222.8 EEA20843.1 - 2.7e-189 629.5 1.0 3.5e-189 629.2 1.0 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A DUF4131 PF13567.6 EEA20843.1 - 0.089 12.4 0.0 1.2 8.8 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Aldo_ket_red PF00248.21 EEA20844.1 - 4.9e-66 222.9 0.0 5.6e-66 222.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SDA1 PF05285.12 EEA20844.1 - 0.14 11.5 0.0 0.2 11.1 0.0 1.1 1 0 0 1 1 1 0 SDA1 DUF3425 PF11905.8 EEA20845.1 - 5.8e-17 61.8 0.0 1e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DnaJ PF00226.31 EEA20846.1 - 4.2e-21 74.9 0.7 6.5e-21 74.2 0.7 1.3 1 0 0 1 1 1 1 DnaJ domain Bacteriocin_IIc PF10439.9 EEA20846.1 - 0.0057 16.8 2.6 0.011 15.8 2.6 1.4 1 0 0 1 1 1 1 Bacteriocin class II with double-glycine leader peptide DUF456 PF04306.13 EEA20846.1 - 0.025 14.9 1.3 0.037 14.3 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Gly-zipper_Omp PF13488.6 EEA20846.1 - 0.26 11.3 10.0 0.51 10.4 10.0 1.5 1 0 0 1 1 1 0 Glycine zipper Gly-zipper_YMGG PF13441.6 EEA20846.1 - 5.2 6.9 12.7 17 5.3 12.9 1.7 1 1 0 1 1 1 0 YMGG-like Gly-zipper PMM PF03332.13 EEA20847.1 - 1.6e-103 345.2 0.1 1.9e-103 345.0 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EEA20847.1 - 0.031 14.0 0.0 0.25 11.0 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase TMPIT PF07851.13 EEA20847.1 - 0.13 11.5 0.1 0.17 11.1 0.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein RRM_1 PF00076.22 EEA20848.1 - 2.1e-51 171.6 0.1 5.7e-18 64.5 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA20848.1 - 1.2e-35 121.2 0.0 1.2e-27 95.5 0.0 4.3 4 0 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EEA20848.1 - 6.1e-09 35.7 0.0 0.0035 17.3 0.0 3.7 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EEA20848.1 - 0.00035 20.6 1.9 0.65 10.1 0.0 4.3 3 1 1 4 4 4 2 RNA binding motif Lsm_interact PF05391.11 EEA20848.1 - 0.092 12.3 0.7 0.24 11.0 0.7 1.8 1 0 0 1 1 1 0 Lsm interaction motif TPR_14 PF13428.6 EEA20848.1 - 1 10.3 5.3 4.7 8.3 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Spore_coat_CotO PF14153.6 EEA20848.1 - 9.9 6.0 11.7 51 3.7 11.7 2.2 1 0 0 1 1 1 0 Spore coat protein CotO L_HMGIC_fpl PF10242.9 EEA20850.1 - 0.00048 20.4 5.7 0.00085 19.6 5.7 1.4 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_3 PF06653.11 EEA20850.1 - 0.048 13.6 10.6 0.15 12.0 10.6 1.8 1 1 0 1 1 1 0 Tight junction protein, Claudin-like TMEM223 PF14640.6 EEA20850.1 - 0.091 12.9 0.5 0.65 10.2 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 223 STE2 PF02116.15 EEA20850.1 - 0.42 9.9 7.1 0.21 10.9 2.7 1.9 1 1 1 2 2 2 0 Fungal pheromone mating factor STE2 GPCR PDR_CDR PF06422.12 EEA20850.1 - 0.5 10.3 2.4 1.4 8.9 0.1 2.6 3 0 0 3 3 3 0 CDR ABC transporter ABC2_membrane PF01061.24 EEA20850.1 - 2.2 7.7 13.0 2.6 7.4 9.0 2.2 2 1 0 2 2 2 0 ABC-2 type transporter L_HMGIC_fpl PF10242.9 EEA20851.1 - 0.00015 22.1 3.8 0.00049 20.4 3.6 1.7 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_3 PF06653.11 EEA20851.1 - 0.015 15.3 5.2 0.034 14.1 5.1 1.6 1 1 0 1 1 1 0 Tight junction protein, Claudin-like PDR_CDR PF06422.12 EEA20851.1 - 0.1 12.5 0.2 0.88 9.5 0.0 2.3 2 0 0 2 2 2 0 CDR ABC transporter SPC12 PF06645.13 EEA20851.1 - 0.13 12.4 0.7 0.13 12.4 0.7 2.7 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) TMEM223 PF14640.6 EEA20851.1 - 0.26 11.4 3.1 0.68 10.1 0.7 2.2 2 1 0 2 2 2 0 Transmembrane protein 223 DHHC PF01529.20 EEA20851.1 - 1.8 8.7 5.2 3.1 7.9 2.1 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase TMEM43 PF07787.12 EEA20851.1 - 4.5 6.6 8.2 0.22 10.9 1.6 1.8 2 0 0 2 2 2 0 Transmembrane protein 43 HHV6-IE PF03753.13 EEA20852.1 - 0.035 11.6 0.7 0.052 11.0 0.7 1.2 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein C2 PF00168.30 EEA20853.1 - 1.2e-14 54.4 0.0 2.1e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain SnoaL_2 PF12680.7 EEA20854.1 - 6.2e-08 33.2 0.0 8.5e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EEA20854.1 - 1.8e-05 25.1 0.0 2.3e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) NTF2 PF02136.20 EEA20854.1 - 3.7e-05 24.3 0.0 5e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LEH PF07858.12 EEA20854.1 - 0.017 15.2 0.0 0.019 15.1 0.0 1.1 1 0 0 1 1 1 0 Limonene-1,2-epoxide hydrolase catalytic domain SnoaL PF07366.12 EEA20854.1 - 0.041 13.7 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase RHD3 PF05879.12 EEA20854.1 - 0.15 10.2 0.0 0.19 9.8 0.0 1.0 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) UTP15_C PF09384.10 EEA20855.1 - 3.5e-53 179.2 0.1 1e-52 177.7 0.3 1.7 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.32 EEA20855.1 - 6.6e-20 71.1 1.8 0.00086 20.1 0.0 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA20855.1 - 4.7e-09 36.4 0.1 0.0034 17.6 0.0 4.7 5 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 EEA20855.1 - 0.00022 20.6 0.2 0.2 10.9 0.1 2.3 2 0 0 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_2 PF13360.6 EEA20855.1 - 0.0036 16.9 0.9 0.03 13.9 0.4 2.3 1 1 1 2 2 2 1 PQQ-like domain CPSF_A PF03178.15 EEA20855.1 - 0.041 13.2 0.0 0.22 10.8 0.0 1.7 1 1 0 2 2 2 0 CPSF A subunit region Fungal_trans PF04082.18 EEA20856.1 - 1.3e-26 93.3 0.0 2.8e-26 92.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20856.1 - 4.8e-06 26.6 9.0 9.9e-06 25.6 9.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAPG_hydrolase PF18089.1 EEA20856.1 - 0.04 13.5 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 DAPG hydrolase PhiG domain CAP_N PF01213.19 EEA20856.1 - 2.9 7.3 9.5 77 2.6 12.7 1.6 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal TFIIA PF03153.13 EEA20856.1 - 4.5 7.1 11.3 7.2 6.5 11.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arg_repressor PF01316.21 EEA20857.1 - 0.048 13.4 0.2 0.39 10.5 0.1 2.6 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain PhyH PF05721.13 EEA20859.1 - 4.2e-43 148.1 0.0 5.6e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EEA20859.1 - 0.03 14.7 0.0 0.06 13.8 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase MFS_MOT1 PF16983.5 EEA20861.1 - 6.1e-63 210.1 35.1 4.8e-34 117.1 10.2 3.1 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily Sulfate_transp PF00916.20 EEA20861.1 - 3.4e-05 22.8 20.5 0.00068 18.5 2.1 2.8 2 1 0 2 2 2 2 Sulfate permease family Xan_ur_permease PF00860.20 EEA20861.1 - 0.00068 18.4 33.0 0.00088 18.1 18.2 2.5 1 1 0 2 2 2 2 Permease family Sulf_transp PF04143.14 EEA20862.1 - 4.1e-05 23.3 15.0 0.006 16.2 3.9 3.2 3 0 0 3 3 3 3 Sulphur transport Peptidase_M28 PF04389.17 EEA20863.1 - 3.1e-30 105.4 0.0 5.4e-30 104.6 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M28 MutS_V PF00488.21 EEA20866.1 - 9.6e-69 231.2 0.1 1.8e-68 230.3 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EEA20866.1 - 1.2e-40 139.8 0.0 2.6e-40 138.7 0.0 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EEA20866.1 - 1.4e-33 115.5 0.6 4.7e-33 113.8 0.1 2.2 3 0 0 3 3 3 1 MutS domain I MutS_II PF05188.17 EEA20866.1 - 7e-13 49.0 0.0 2e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EEA20866.1 - 1.1e-12 48.1 0.2 2.4e-12 47.0 0.2 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.6 EEA20866.1 - 0.013 16.0 0.0 0.013 16.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EEA20866.1 - 0.038 13.7 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EEA20866.1 - 0.085 12.4 0.0 0.24 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EEA20866.1 - 0.21 11.3 3.4 0.11 12.3 0.2 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system tRNA-synt_1b PF00579.25 EEA20867.1 - 2e-73 247.3 0.0 2.7e-73 246.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EEA20867.1 - 9e-43 144.9 0.0 1.6e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain S4 PF01479.25 EEA20867.1 - 0.012 15.3 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 S4 domain tRNA-synt_2 PF00152.20 EEA20868.1 - 1.4e-90 303.6 0.0 3.7e-90 302.2 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA20868.1 - 0.0003 20.7 0.0 0.0014 18.5 0.0 2.0 1 1 1 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 EEA20868.1 - 0.011 15.8 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Glyco_hydro_71 PF03659.14 EEA20869.1 - 3.5e-131 437.5 5.1 4.2e-131 437.2 5.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 NPCBM PF08305.11 EEA20869.1 - 0.13 12.4 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 NPCBM/NEW2 domain CS PF04969.16 EEA20870.1 - 3e-16 60.2 0.0 5.9e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 CS domain Ribosomal_L14 PF00238.19 EEA20871.1 - 2.2e-34 118.2 0.0 2.6e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Endonuc-FokI_C PF09254.11 EEA20871.1 - 0.077 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal Ribosomal_L14 PF00238.19 EEA20872.1 - 1.4e-33 115.5 0.0 1.5e-33 115.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Endonuc-FokI_C PF09254.11 EEA20872.1 - 0.056 12.7 0.0 0.074 12.3 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal Hist_deacetyl PF00850.19 EEA20873.1 - 1.5e-81 274.3 0.0 2.9e-81 273.3 0.0 1.5 1 0 0 1 1 1 1 Histone deacetylase domain JAB PF01398.21 EEA20874.1 - 9.4e-33 112.7 0.0 1.8e-32 111.8 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EEA20874.1 - 3.3e-12 46.8 0.7 5.2e-12 46.2 0.7 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EEA20874.1 - 4.9e-07 29.5 0.0 9.5e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain NIF PF03031.18 EEA20875.1 - 2.2e-41 141.2 0.0 3.1e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Menin PF05053.13 EEA20875.1 - 7.3 4.8 6.5 12 4.1 6.5 1.2 1 0 0 1 1 1 0 Menin Beta_elim_lyase PF01212.21 EEA20877.1 - 1.8e-68 231.0 0.0 2.4e-68 230.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Beta_elim_lyase PF01212.21 EEA20878.1 - 4.1e-60 203.6 0.0 5.3e-60 203.2 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Beta_elim_lyase PF01212.21 EEA20879.1 - 3.3e-60 203.8 0.0 4.2e-60 203.5 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Fungal_trans PF04082.18 EEA20880.1 - 4.1e-14 52.2 0.0 7.5e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20880.1 - 1.2e-06 28.5 6.7 3e-06 27.2 6.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.32 EEA20881.1 - 0.083 13.8 1.2 55 4.9 0.0 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat F-box PF00646.33 EEA20881.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 F-box domain GRDP-like PF07173.12 EEA20882.1 - 2.2e-19 70.5 0.7 2.6e-13 50.8 0.1 2.7 2 0 0 2 2 2 2 Glycine-rich domain-containing protein-like Fungal_trans PF04082.18 EEA20883.1 - 9.4e-10 38.0 0.3 1.7e-09 37.1 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20883.1 - 1.3e-06 28.4 9.6 1.3e-06 28.4 9.6 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DivIC PF04977.15 EEA20883.1 - 0.061 13.1 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 Septum formation initiator NUDE_C PF04880.13 EEA20883.1 - 9.6 6.6 8.3 1.5 9.2 0.6 2.9 3 1 1 4 4 4 0 NUDE protein, C-terminal conserved region DNA_photolyase PF00875.18 EEA20884.1 - 2e-20 73.5 1.8 2e-20 73.5 1.8 2.2 2 1 0 2 2 2 1 DNA photolyase MFS_1 PF07690.16 EEA20885.1 - 1.2e-34 119.8 43.3 3.5e-29 101.9 26.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20885.1 - 6.5e-18 64.8 23.7 1.2e-16 60.7 23.6 2.8 1 1 0 1 1 1 1 Sugar (and other) transporter PI3K_P85_iSH2 PF16454.5 EEA20886.1 - 0.0089 15.6 22.7 0.066 12.8 0.3 5.4 2 2 2 4 4 4 2 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Imm7 PF15585.6 EEA20886.1 - 0.042 14.1 4.2 0.071 13.4 0.1 3.3 3 1 1 4 4 4 0 Immunity protein 7 DUF1664 PF07889.12 EEA20886.1 - 0.047 13.7 23.6 0.12 12.5 2.8 4.9 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) ZapB PF06005.12 EEA20886.1 - 0.16 12.4 30.0 3.3 8.2 0.0 6.1 3 2 1 4 4 4 0 Cell division protein ZapB ADIP PF11559.8 EEA20886.1 - 0.18 11.9 25.7 0.18 11.8 2.6 4.3 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.12 EEA20886.1 - 0.27 11.7 25.8 2.4 8.7 1.8 6.9 4 3 2 6 6 6 0 Nucleopolyhedrovirus P10 protein DUF4164 PF13747.6 EEA20886.1 - 0.32 11.3 34.3 0.13 12.6 1.2 6.5 2 2 4 7 7 7 0 Domain of unknown function (DUF4164) BLOC1_2 PF10046.9 EEA20886.1 - 1.6 9.0 21.5 9.1 6.7 1.1 6.2 2 2 4 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4618 PF15397.6 EEA20886.1 - 1.7 8.0 23.1 0.071 12.5 8.2 4.1 1 1 2 4 4 4 0 Domain of unknown function (DUF4618) Methyltransf_32 PF13679.6 EEA20886.1 - 2 8.4 4.3 1.4 8.9 1.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain Exonuc_VII_L PF02601.15 EEA20886.1 - 2.4 7.7 22.0 1.3 8.5 3.9 3.1 1 1 2 3 3 3 0 Exonuclease VII, large subunit ATG16 PF08614.11 EEA20886.1 - 2.6 8.2 38.8 18 5.5 2.2 6.1 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 EEA20886.1 - 3.1 8.3 23.5 2.2 8.7 0.8 6.7 6 3 3 9 9 9 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 EEA20886.1 - 3.9 8.1 24.3 7.2 7.2 0.0 5.1 1 1 3 5 5 5 0 Syntaxin 6, N-terminal CK2S PF15011.6 EEA20886.1 - 5.2 6.9 12.4 0.11 12.4 2.3 2.9 3 0 0 3 3 3 0 Casein Kinase 2 substrate DUF641 PF04859.12 EEA20886.1 - 7.1 7.0 16.4 2.5 8.4 0.3 4.5 3 2 1 4 4 4 0 Plant protein of unknown function (DUF641) DUF4988 PF16378.5 EEA20886.1 - 8.2 6.1 12.5 31 4.2 0.3 5.2 4 2 1 5 5 5 0 Domain of unknown function AA_permease PF00324.21 EEA20887.1 - 2.2e-103 346.5 42.4 2.6e-103 346.2 42.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA20887.1 - 3.6e-21 75.5 43.7 5.2e-21 75.0 43.7 1.2 1 0 0 1 1 1 1 Amino acid permease Aldolase_II PF00596.21 EEA20888.1 - 6e-47 160.0 0.3 8.1e-47 159.6 0.3 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain p450 PF00067.22 EEA20889.1 - 1.2e-56 192.5 0.0 4.9e-56 190.4 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 EEA20890.1 - 2e-72 243.7 0.0 3.5e-72 242.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20890.1 - 9e-37 126.7 0.0 2.7e-36 125.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA20890.1 - 0.0012 18.2 1.0 0.89 8.8 0.0 3.0 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 EEA20890.1 - 0.046 13.6 0.8 1.8 8.5 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Spa1_C PF18218.1 EEA20890.1 - 0.06 13.8 0.3 0.36 11.3 0.3 2.2 1 1 0 1 1 1 0 Lantibiotic immunity protein Spa1 C-terminal domain MFS_1 PF07690.16 EEA20892.1 - 1.6e-37 129.3 62.6 2.8e-35 121.9 45.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20892.1 - 3.7e-10 39.3 39.6 1.5e-07 30.6 14.4 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter Mito_carr PF00153.27 EEA20894.1 - 1.8e-64 213.7 1.7 4.9e-22 77.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein 2-Hacid_dh_C PF02826.19 EEA20895.1 - 1.8e-53 180.5 0.0 2.6e-53 180.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA20895.1 - 9.9e-22 77.0 0.1 1.4e-21 76.6 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA20895.1 - 3.5e-06 27.3 0.0 6.2e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EEA20895.1 - 0.00034 21.1 0.0 0.00084 19.9 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Gp_dh_N PF00044.24 EEA20895.1 - 0.034 14.5 0.1 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA20895.1 - 0.07 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EEA20895.1 - 0.11 13.3 0.0 0.24 12.2 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ldh_2 PF02615.14 EEA20896.1 - 1.1e-28 100.4 0.0 1.3e-28 100.2 0.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase MFS_1 PF07690.16 EEA20897.1 - 1.3e-46 159.2 26.2 2e-44 151.9 28.1 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA20897.1 - 2.1e-14 52.9 18.4 3e-14 52.4 18.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA20897.1 - 2.9e-11 42.9 13.3 7.7e-11 41.5 13.3 1.7 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EEA20897.1 - 3.4e-06 26.2 1.7 3.4e-06 26.2 1.7 2.9 3 0 0 3 3 3 1 MFS_1 like family HAMP PF00672.25 EEA20898.1 - 1.2e-42 144.0 15.5 1.5e-08 34.9 0.0 7.5 6 2 1 7 7 7 5 HAMP domain HATPase_c PF02518.26 EEA20898.1 - 2.9e-33 114.7 0.4 2.2e-32 111.9 0.1 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EEA20898.1 - 1.2e-25 89.8 0.9 4.6e-25 88.0 0.5 2.3 2 0 0 2 2 1 1 Response regulator receiver domain HisKA PF00512.25 EEA20898.1 - 4.6e-16 58.6 5.0 4.9e-16 58.5 0.1 3.8 5 0 0 5 5 3 1 His Kinase A (phospho-acceptor) domain APG17 PF04108.12 EEA20898.1 - 1.1e-11 44.5 6.6 0.026 13.7 0.0 5.6 1 1 3 4 4 4 3 Autophagy protein Apg17 Syntaxin_2 PF14523.6 EEA20898.1 - 4.6e-07 30.1 13.0 0.73 10.2 0.0 6.6 3 2 0 6 6 5 1 Syntaxin-like protein DUF4279 PF14106.6 EEA20898.1 - 4.6e-05 23.6 0.0 13 6.0 0.0 5.5 5 1 0 5 5 5 0 Domain of unknown function (DUF4279) DUF948 PF06103.11 EEA20898.1 - 0.0021 18.3 53.1 1.6 9.1 0.2 9.9 4 2 2 6 6 5 1 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 EEA20898.1 - 0.0029 17.7 5.1 0.0029 17.7 5.1 6.9 1 1 3 5 5 5 1 Baculovirus polyhedron envelope protein, PEP, C terminus WXG100 PF06013.12 EEA20898.1 - 0.004 17.3 24.4 3.2 8.1 0.7 8.1 7 1 0 7 7 7 1 Proteins of 100 residues with WXG DUF1843 PF08898.10 EEA20898.1 - 0.013 16.0 5.0 27 5.4 0.0 5.9 5 1 0 5 5 5 0 Domain of unknown function (DUF1843) DUF3829 PF12889.7 EEA20898.1 - 0.022 14.3 15.2 0.17 11.3 0.6 5.0 4 2 3 7 7 6 0 Protein of unknown function (DUF3829) Gp-FAR-1 PF05823.12 EEA20898.1 - 0.023 15.0 4.9 45 4.4 0.1 4.9 1 1 2 5 5 5 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Fib_alpha PF08702.10 EEA20898.1 - 0.027 14.7 30.4 0.87 9.8 0.7 7.2 6 1 1 7 7 7 0 Fibrinogen alpha/beta chain family DUF4795 PF16043.5 EEA20898.1 - 0.03 13.9 22.4 1.1 8.9 6.9 4.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4795) NOD PF06816.13 EEA20898.1 - 0.043 13.4 0.0 6.2 6.5 0.0 2.7 2 0 0 2 2 2 0 NOTCH protein IcmF_C PF06744.12 EEA20898.1 - 0.088 12.4 0.1 0.28 10.8 0.1 1.8 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal PA-IL PF07828.12 EEA20898.1 - 0.096 12.7 2.5 2.1 8.4 0.1 2.8 2 0 0 2 2 2 0 PA-IL-like protein CMD PF02627.20 EEA20898.1 - 0.11 12.6 0.3 13 5.9 0.0 3.5 4 0 0 4 4 3 0 Carboxymuconolactone decarboxylase family DUF2457 PF10446.9 EEA20898.1 - 0.12 11.5 17.3 0.22 10.6 17.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-F_leu_zip PF10473.9 EEA20898.1 - 0.29 11.2 31.4 0.68 10.0 0.1 8.2 7 2 1 8 8 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GLE1 PF07817.13 EEA20898.1 - 0.37 10.0 9.4 17 4.5 0.0 4.3 2 1 3 5 5 5 0 GLE1-like protein DNA_pol_phi PF04931.13 EEA20898.1 - 0.76 7.8 20.3 0.13 10.4 16.4 1.6 2 0 0 2 2 2 0 DNA polymerase phi DUF1759 PF03564.15 EEA20898.1 - 0.91 9.4 6.4 26 4.7 0.0 4.8 4 1 0 5 5 4 0 Protein of unknown function (DUF1759) Fez1 PF06818.15 EEA20898.1 - 1.4 9.3 20.9 17 5.8 3.4 4.3 1 1 1 2 2 1 0 Fez1 YL1 PF05764.13 EEA20898.1 - 1.6 8.8 14.5 3.5 7.7 14.5 1.5 1 0 0 1 1 1 0 YL1 nuclear protein AAA_13 PF13166.6 EEA20898.1 - 1.7 7.2 29.1 0.061 12.0 4.8 4.0 2 1 2 4 4 4 0 AAA domain BORCS6 PF10157.9 EEA20898.1 - 2.5 8.3 12.4 26 5.0 0.1 5.3 3 2 2 6 6 5 0 BLOC-1-related complex sub-unit 6 Mer2 PF09074.10 EEA20898.1 - 2.7 7.8 34.3 3.4 7.4 2.7 6.2 4 1 1 5 5 5 0 Mer2 DUF5593 PF18007.1 EEA20898.1 - 3.6 8.3 9.4 57 4.5 0.1 5.0 4 1 0 4 4 4 0 Domain of unknown function (DUF5593) PPP4R2 PF09184.11 EEA20898.1 - 4 6.9 11.0 12 5.4 11.0 1.8 1 0 0 1 1 1 0 PPP4R2 RXT2_N PF08595.11 EEA20898.1 - 4.8 7.2 10.7 17 5.4 10.7 1.9 1 0 0 1 1 1 0 RXT2-like, N-terminal Phage_Mu_Gam PF07352.12 EEA20898.1 - 5.6 6.9 13.8 17 5.3 0.1 5.5 4 1 1 6 6 6 0 Bacteriophage Mu Gam like protein SpoIIID PF12116.8 EEA20898.1 - 6.4 6.9 11.9 40 4.4 0.2 5.9 6 1 1 7 7 5 0 Stage III sporulation protein D RNA_pol_3_Rpc31 PF11705.8 EEA20898.1 - 7.4 6.7 17.3 2.7 8.2 14.3 1.8 2 0 0 2 2 1 0 DNA-directed RNA polymerase III subunit Rpc31 HAMP PF00672.25 EEA20899.1 - 1.4e-42 143.8 15.5 1.5e-08 34.9 0.0 7.4 6 2 1 7 7 7 5 HAMP domain HATPase_c PF02518.26 EEA20899.1 - 2.9e-33 114.7 0.4 2.2e-32 111.9 0.1 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EEA20899.1 - 1.2e-25 89.8 0.9 4.6e-25 88.0 0.5 2.3 2 0 0 2 2 1 1 Response regulator receiver domain HisKA PF00512.25 EEA20899.1 - 4.7e-16 58.6 5.0 4.9e-16 58.5 0.1 3.8 5 0 0 5 5 3 1 His Kinase A (phospho-acceptor) domain APG17 PF04108.12 EEA20899.1 - 8.8e-12 44.8 6.2 0.0035 16.5 0.0 5.6 1 1 2 3 3 3 3 Autophagy protein Apg17 Syntaxin_2 PF14523.6 EEA20899.1 - 4.5e-07 30.2 13.0 0.73 10.2 0.0 6.6 3 2 0 6 6 5 1 Syntaxin-like protein DUF4279 PF14106.6 EEA20899.1 - 4.7e-05 23.6 0.0 13 6.0 0.0 5.5 5 1 0 5 5 5 0 Domain of unknown function (DUF4279) DUF948 PF06103.11 EEA20899.1 - 0.0021 18.3 53.1 1.6 9.1 0.2 9.9 4 2 1 6 6 5 1 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 EEA20899.1 - 0.0026 17.8 4.9 0.0026 17.8 4.9 6.9 1 1 3 5 5 5 1 Baculovirus polyhedron envelope protein, PEP, C terminus WXG100 PF06013.12 EEA20899.1 - 0.0044 17.2 24.5 3.2 8.1 0.7 8.1 7 1 0 7 7 7 1 Proteins of 100 residues with WXG DUF1843 PF08898.10 EEA20899.1 - 0.013 16.0 5.0 27 5.4 0.0 5.9 5 1 0 5 5 5 0 Domain of unknown function (DUF1843) DUF3829 PF12889.7 EEA20899.1 - 0.021 14.3 15.2 0.17 11.3 0.6 5.0 4 2 3 7 7 6 0 Protein of unknown function (DUF3829) Gp-FAR-1 PF05823.12 EEA20899.1 - 0.024 15.0 4.9 45 4.4 0.1 4.9 1 1 2 5 5 5 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF4795 PF16043.5 EEA20899.1 - 0.026 14.1 22.2 0.46 10.1 5.3 4.9 1 1 4 5 5 5 0 Domain of unknown function (DUF4795) Fib_alpha PF08702.10 EEA20899.1 - 0.03 14.5 30.6 0.87 9.8 0.7 7.2 6 1 1 7 7 7 0 Fibrinogen alpha/beta chain family NOD PF06816.13 EEA20899.1 - 0.043 13.4 0.0 6.3 6.5 0.0 2.7 2 0 0 2 2 2 0 NOTCH protein IcmF_C PF06744.12 EEA20899.1 - 0.088 12.4 0.1 0.28 10.8 0.1 1.8 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal PA-IL PF07828.12 EEA20899.1 - 0.097 12.7 2.5 2.1 8.3 0.1 2.8 2 0 0 2 2 2 0 PA-IL-like protein CMD PF02627.20 EEA20899.1 - 0.11 12.6 0.3 13 5.9 0.0 3.5 4 0 0 4 4 3 0 Carboxymuconolactone decarboxylase family DUF2457 PF10446.9 EEA20899.1 - 0.12 11.4 17.3 0.22 10.6 17.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-F_leu_zip PF10473.9 EEA20899.1 - 0.3 11.1 31.4 0.68 9.9 0.1 8.2 7 2 1 8 8 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GLE1 PF07817.13 EEA20899.1 - 0.31 10.2 9.1 9.5 5.3 0.0 4.3 2 1 3 5 5 5 0 GLE1-like protein DNA_pol_phi PF04931.13 EEA20899.1 - 0.76 7.8 20.3 0.13 10.4 16.4 1.6 2 0 0 2 2 2 0 DNA polymerase phi DUF1759 PF03564.15 EEA20899.1 - 0.93 9.4 6.4 26 4.7 0.0 4.8 4 1 0 5 5 4 0 Protein of unknown function (DUF1759) Fez1 PF06818.15 EEA20899.1 - 1.3 9.4 20.7 15 6.0 3.2 4.3 1 1 1 2 2 2 0 Fez1 YL1 PF05764.13 EEA20899.1 - 1.5 8.9 14.5 3.6 7.6 14.5 1.6 1 0 0 1 1 1 0 YL1 nuclear protein AAA_13 PF13166.6 EEA20899.1 - 1.8 7.1 29.1 0.062 11.9 4.7 4.0 2 1 1 4 4 4 0 AAA domain BORCS6 PF10157.9 EEA20899.1 - 2.6 8.3 12.5 26 5.0 0.1 5.3 3 2 2 6 6 5 0 BLOC-1-related complex sub-unit 6 Mer2 PF09074.10 EEA20899.1 - 2.7 7.7 34.3 3.4 7.4 2.7 6.2 4 1 1 5 5 5 0 Mer2 DUF5593 PF18007.1 EEA20899.1 - 3.5 8.4 9.3 57 4.5 0.1 5.0 4 1 0 4 4 4 0 Domain of unknown function (DUF5593) PPP4R2 PF09184.11 EEA20899.1 - 4 6.9 11.0 12 5.4 11.0 1.8 1 0 0 1 1 1 0 PPP4R2 RXT2_N PF08595.11 EEA20899.1 - 4.8 7.2 10.7 17 5.4 10.7 1.9 1 0 0 1 1 1 0 RXT2-like, N-terminal Phage_Mu_Gam PF07352.12 EEA20899.1 - 5.5 6.9 13.8 16 5.4 0.3 5.5 4 1 1 6 6 6 0 Bacteriophage Mu Gam like protein SpoIIID PF12116.8 EEA20899.1 - 6.6 6.9 11.9 40 4.4 0.2 5.9 6 1 1 7 7 5 0 Stage III sporulation protein D RNA_pol_3_Rpc31 PF11705.8 EEA20899.1 - 7.5 6.7 17.3 2.7 8.2 14.3 1.8 2 0 0 2 2 1 0 DNA-directed RNA polymerase III subunit Rpc31 tRNA-synt_2d PF01409.20 EEA20900.1 - 1.3e-86 290.1 0.0 1.7e-86 289.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EEA20900.1 - 3.8e-16 59.1 0.2 1.1e-15 57.7 0.2 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EEA20900.1 - 3.9e-07 29.7 0.0 0.0027 17.2 0.0 2.5 3 0 0 3 3 3 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 EEA20900.1 - 5.2e-05 22.5 0.1 0.0031 16.6 0.0 2.9 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 EEA20900.1 - 0.00019 21.3 0.3 0.00055 19.9 0.3 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 Ribosomal_S21e PF01249.18 EEA20901.1 - 2.7e-40 136.4 0.0 3e-40 136.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e NUDIX PF00293.28 EEA20902.1 - 8.3e-07 29.1 0.0 2.1e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain IMPDH PF00478.25 EEA20903.1 - 3.9e-128 427.3 3.3 4.6e-128 427.1 3.3 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EEA20903.1 - 2.1e-19 69.7 0.1 1.4e-10 41.4 0.0 2.6 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 EEA20903.1 - 8.9e-07 28.2 0.6 9e-06 24.9 0.5 2.3 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EEA20903.1 - 1.6e-05 24.4 6.3 0.021 14.2 5.7 2.7 2 1 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 EEA20903.1 - 0.0002 20.9 0.9 0.00051 19.6 0.9 1.6 1 0 0 1 1 1 1 Histidine biosynthesis protein Aldolase PF01081.19 EEA20903.1 - 0.0025 17.3 0.8 0.011 15.2 0.1 2.1 2 0 0 2 2 2 1 KDPG and KHG aldolase YpsA PF06908.11 EEA20903.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family PK PF00224.21 EEA20903.1 - 0.036 13.0 0.0 0.06 12.2 0.0 1.3 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain ThiG PF05690.14 EEA20903.1 - 0.092 12.0 1.2 0.22 10.8 0.5 1.8 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG SHNi-TPR PF10516.9 EEA20903.1 - 0.16 11.5 0.0 0.43 10.1 0.0 1.7 2 0 0 2 2 2 0 SHNi-TPR adh_short PF00106.25 EEA20904.1 - 5e-31 107.7 0.7 8.4e-29 100.4 0.7 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA20904.1 - 1.3e-28 100.2 1.4 1e-26 93.9 1.4 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA20904.1 - 0.0049 16.8 0.0 0.0071 16.3 0.0 1.4 1 1 0 1 1 1 1 KR domain FKBP_N_2 PF18023.1 EEA20904.1 - 0.03 14.4 0.1 0.052 13.6 0.1 1.3 1 0 0 1 1 1 0 BDBT FKBP like N-terminal THF_DHG_CYH_C PF02882.19 EEA20904.1 - 0.065 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF952 PF06108.12 EEA20905.1 - 1.6e-21 76.1 0.0 2.1e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) RasGAP_C PF03836.15 EEA20906.1 - 3.1e-47 160.2 4.8 3.1e-47 160.2 4.8 2.6 2 0 0 2 2 2 1 RasGAP C-terminus RasGAP PF00616.19 EEA20906.1 - 6.2e-45 153.5 0.2 1.9e-44 151.9 0.0 2.0 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 EEA20906.1 - 4.2e-12 46.2 0.0 1.3e-11 44.6 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain IQ PF00612.27 EEA20906.1 - 1.1e-08 34.1 52.6 0.51 10.3 0.5 13.6 16 0 0 16 16 16 7 IQ calmodulin-binding motif CAMSAP_CH PF11971.8 EEA20906.1 - 0.0068 16.2 0.1 0.025 14.4 0.0 2.0 2 0 0 2 2 2 1 CAMSAP CH domain Trypan_PARP PF05887.11 EEA20906.1 - 0.021 14.8 0.3 0.04 13.9 0.3 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ENTH PF01417.20 EEA20907.1 - 8.7e-46 155.0 0.2 1.2e-45 154.6 0.2 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EEA20907.1 - 3.2e-05 23.1 0.1 4.6e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 ANTH domain DUF5102 PF17104.5 EEA20907.1 - 1.2 9.1 6.1 2.7 7.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) GIT_SHD PF08518.11 EEA20908.1 - 9.8e-25 85.9 5.8 2e-13 49.7 0.6 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 EEA20908.1 - 4.9e-05 23.4 0.1 4.9e-05 23.4 0.1 3.7 3 1 2 5 5 5 1 G protein-coupled receptor kinase-interacting protein 1 C term APG6_N PF17675.1 EEA20908.1 - 0.0027 18.2 16.7 0.0027 18.2 16.7 3.1 2 1 1 3 3 3 1 Apg6 coiled-coil region Taxilin PF09728.9 EEA20908.1 - 0.033 13.4 37.3 0.21 10.7 14.2 2.4 2 0 0 2 2 2 0 Myosin-like coiled-coil protein DUF4407 PF14362.6 EEA20908.1 - 0.05 12.9 23.9 0.042 13.2 20.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.9 EEA20908.1 - 0.077 13.0 36.8 0.66 10.0 5.2 3.9 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 EEA20908.1 - 0.2 11.5 40.6 0.016 15.0 25.6 3.0 2 1 0 3 3 3 0 Ezrin/radixin/moesin family Fmp27_WPPW PF10359.9 EEA20908.1 - 0.29 9.9 27.7 28 3.4 27.7 2.2 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain EzrA PF06160.12 EEA20908.1 - 1 7.4 30.8 0.18 9.9 20.6 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA bZIP_1 PF00170.21 EEA20908.1 - 1.5 9.0 30.3 0.84 9.8 2.7 4.9 4 0 0 4 4 4 0 bZIP transcription factor XLF PF09302.11 EEA20908.1 - 2.6 8.2 10.8 0.062 13.5 1.2 2.6 2 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component ATG16 PF08614.11 EEA20908.1 - 4.6 7.4 40.1 2.5 8.3 9.2 3.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF948 PF06103.11 EEA20908.1 - 4.6 7.6 12.4 0.14 12.5 0.3 4.0 4 1 0 4 4 3 0 Bacterial protein of unknown function (DUF948) Jnk-SapK_ap_N PF09744.9 EEA20908.1 - 5.4 7.2 44.7 0.9 9.8 21.5 4.2 3 1 1 4 4 4 0 JNK_SAPK-associated protein-1 Fez1 PF06818.15 EEA20908.1 - 6.8 7.1 35.3 6.2 7.2 12.1 2.7 1 1 1 2 2 2 0 Fez1 HisKA_3 PF07730.13 EEA20908.1 - 9.9 6.8 10.5 11 6.6 0.8 4.1 4 0 0 4 4 2 0 Histidine kinase SNF2_N PF00176.23 EEA20909.1 - 2.5e-51 174.4 0.1 3.7e-51 173.9 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 EEA20909.1 - 3.3e-25 88.0 0.9 1e-24 86.4 0.9 1.9 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 EEA20909.1 - 7.7e-21 74.5 0.0 1.5e-18 67.2 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EEA20909.1 - 1.9e-07 30.5 0.0 4.5e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EEA20909.1 - 1.4e-06 28.4 0.1 7e-06 26.1 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA20909.1 - 0.0048 16.7 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase RNase_PH PF01138.21 EEA20910.1 - 3.5e-35 121.4 0.5 6.7e-35 120.5 0.5 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Pro_isomerase PF00160.21 EEA20911.1 - 8.5e-46 156.1 0.2 1.2e-45 155.6 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SH3_1 PF00018.28 EEA20912.1 - 1.4e-11 43.8 0.0 4.1e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EEA20912.1 - 4.3e-09 36.1 0.0 8.9e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EEA20912.1 - 2.5e-07 30.3 0.0 5.3e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PolyA_pol PF01743.20 EEA20913.1 - 2.5e-23 82.9 0.4 1.1e-13 51.7 0.6 2.4 1 1 1 2 2 2 2 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EEA20913.1 - 0.00011 21.9 0.0 0.00025 20.7 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A BTP PF05232.12 EEA20914.1 - 2.1 8.5 6.4 0.98 9.5 0.4 2.6 2 0 0 2 2 2 0 Chlorhexidine efflux transporter HMG-CoA_red PF00368.18 EEA20915.1 - 1.5e-139 465.1 8.4 1.9e-139 464.7 8.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EEA20915.1 - 2.6e-46 157.3 0.0 4.8e-46 156.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EEA20915.1 - 2.2e-14 53.6 4.2 6e-14 52.2 4.2 1.8 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EEA20915.1 - 1.3e-09 36.7 1.1 1.5e-09 36.5 0.1 1.5 2 0 0 2 2 2 1 Patched family Acyl-CoA_dh_1 PF00441.24 EEA20916.1 - 6.5e-17 62.1 0.1 1.9e-16 60.6 0.1 1.8 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 EEA20916.1 - 4.8e-12 46.1 0.0 8.4e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA20916.1 - 1.7e-10 41.0 0.0 3.5e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA20916.1 - 0.043 14.1 0.0 0.16 12.2 0.0 2.0 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Ssu72 PF04722.13 EEA20917.1 - 2.2e-81 272.0 0.0 2.6e-81 271.8 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein Isochorismatase PF00857.20 EEA20918.1 - 6.5e-22 78.5 0.0 3.8e-21 76.0 0.0 2.0 1 1 0 1 1 1 1 Isochorismatase family Ribosomal_S7 PF00177.21 EEA20918.1 - 0.013 15.1 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e DUF3605 PF12239.8 EEA20919.1 - 7.3e-40 136.8 0.0 1e-39 136.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) DUF3605 PF12239.8 EEA20920.1 - 3e-14 53.6 0.0 4.4e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Oxysterol_BP PF01237.18 EEA20921.1 - 7.3e-91 304.8 0.1 7.4e-81 271.8 0.0 2.1 1 1 1 2 2 2 2 Oxysterol-binding protein Oxysterol_BP PF01237.18 EEA20922.1 - 1.6e-91 307.0 0.1 4e-81 272.7 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein Hist_deacetyl PF00850.19 EEA20923.1 - 3e-77 260.1 0.0 4.5e-77 259.6 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain CBP PF12192.8 EEA20923.1 - 0.15 12.2 0.0 0.9 9.8 0.0 2.0 2 0 0 2 2 2 0 Fungal calcium binding protein Saw1 PF11561.8 EEA20925.1 - 0.0096 15.5 0.4 0.055 13.0 0.4 2.0 2 0 0 2 2 2 1 Single strand annealing-weakened 1 Hist_deacetyl PF00850.19 EEA20926.1 - 0.17 11.3 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Histone deacetylase domain Peptidase_M20 PF01546.28 EEA20927.1 - 1.4e-21 77.2 0.0 2.1e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA20927.1 - 4.4e-14 52.3 0.0 1.2e-13 50.9 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Aldo_ket_red PF00248.21 EEA20928.1 - 7.3e-15 54.9 0.0 8.4e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 EEA20929.1 - 4.2e-19 68.8 0.0 4.7e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 EEA20930.1 - 4.9e-64 216.8 0.0 6.4e-64 216.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_10 PF13460.6 EEA20931.1 - 1.6e-18 67.3 0.1 2.1e-18 66.8 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA20931.1 - 0.0036 16.8 0.0 0.0056 16.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Corona_nucleoca PF00937.18 EEA20933.1 - 0.019 14.0 1.1 0.037 13.1 1.1 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein SR-25 PF10500.9 EEA20933.1 - 0.66 9.6 8.1 1.5 8.3 8.1 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MIOX PF05153.15 EEA20934.1 - 2.7e-123 410.4 0.3 4.8e-123 409.6 0.3 1.4 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 EEA20934.1 - 0.024 14.8 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 HD domain NOG1_N PF17835.1 EEA20934.1 - 0.025 14.6 0.9 0.79 9.7 0.1 2.6 2 1 0 2 2 2 0 NOG1 N-terminal helical domain UBD PF16455.5 EEA20934.1 - 0.06 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-binding domain Aldo_ket_red PF00248.21 EEA20935.1 - 2.3e-44 151.7 0.1 3.3e-42 144.7 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family FAT PF02259.23 EEA20937.1 - 1.5e-132 442.0 0.3 1.5e-132 442.0 0.3 2.2 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EEA20937.1 - 1e-68 231.9 0.8 1.9e-68 231.0 0.1 1.9 2 0 0 2 2 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EEA20937.1 - 9.2e-65 217.5 8.2 9.7e-61 204.4 0.4 4.7 4 1 0 4 4 4 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EEA20937.1 - 1.3e-40 137.8 0.2 1.3e-40 137.8 0.2 4.4 5 0 0 5 5 3 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 EEA20937.1 - 3.9e-17 62.4 13.1 0.00018 21.8 0.0 9.5 8 2 1 9 9 8 3 HEAT repeats HEAT_EZ PF13513.6 EEA20937.1 - 1e-16 61.0 13.4 0.0004 20.8 0.0 11.7 10 1 3 13 13 11 5 HEAT-like repeat HEAT PF02985.22 EEA20937.1 - 3.2e-15 54.9 21.8 0.0047 17.1 0.0 12.7 13 0 0 13 13 11 3 HEAT repeat FATC PF02260.20 EEA20937.1 - 2.4e-13 49.6 3.5 2.7e-13 49.5 1.0 2.3 2 0 0 2 2 2 1 FATC domain UME PF08064.13 EEA20937.1 - 0.00031 20.6 5.1 2.1 8.3 0.0 7.1 6 2 1 7 7 7 1 UME (NUC010) domain Sec7_N PF12783.7 EEA20937.1 - 0.0011 18.9 0.2 0.087 12.7 0.0 4.1 5 0 0 5 5 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal CLASP_N PF12348.8 EEA20937.1 - 0.0023 17.5 1.8 2.2 7.8 0.0 4.9 5 0 0 5 5 5 1 CLASP N terminal Vac14_Fab1_bd PF12755.7 EEA20937.1 - 0.0056 17.3 5.3 4.4e+02 1.6 0.0 8.0 7 2 0 8 8 7 0 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EEA20937.1 - 0.021 13.9 10.5 0.086 11.9 0.1 4.5 3 1 0 3 3 3 0 RNAPII transcription regulator C-terminal TPR_7 PF13176.6 EEA20937.1 - 0.06 13.4 1.7 26 5.1 0.1 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Spore_III_AB PF09548.10 EEA20937.1 - 0.11 12.7 0.2 5.2 7.2 0.0 4.0 3 1 0 3 3 2 0 Stage III sporulation protein AB (spore_III_AB) TPR_19 PF14559.6 EEA20937.1 - 0.16 12.5 8.4 12 6.5 0.0 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA20937.1 - 0.17 12.1 4.4 44 4.5 0.2 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EEA20937.1 - 0.17 11.6 3.2 3.1 7.5 0.0 3.9 3 0 0 3 3 3 0 TPR repeat RTP1_C1 PF10363.9 EEA20937.1 - 0.23 11.7 1.1 37 4.6 0.0 4.8 4 1 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 ANAPC3 PF12895.7 EEA20937.1 - 0.62 10.3 3.0 1.1e+02 3.2 0.1 4.3 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EEA20937.1 - 1.4 8.8 4.5 46 4.1 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA20937.1 - 1.6 9.5 0.0 1.6 9.5 0.0 4.3 5 0 0 5 5 3 0 Tetratricopeptide repeat Epimerase PF01370.21 EEA20938.1 - 8.4e-16 58.2 0.0 1.2e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA20938.1 - 6.3e-13 48.4 0.0 8.5e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EEA20938.1 - 4.2e-10 39.2 0.1 7e-09 35.2 0.1 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EEA20938.1 - 9.1e-08 31.9 0.0 1.4e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EEA20938.1 - 5.9e-07 29.5 0.0 2.1e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EEA20938.1 - 0.0016 18.4 0.0 0.0028 17.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EEA20938.1 - 0.016 14.7 0.1 0.13 11.8 0.0 2.1 2 0 0 2 2 2 0 NmrA-like family adh_short PF00106.25 EEA20938.1 - 0.023 14.2 0.0 0.043 13.3 0.0 1.6 1 1 0 1 1 1 0 short chain dehydrogenase Semialdhyde_dh PF01118.24 EEA20938.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EEA20938.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Mit_ribos_Mrp51 PF11709.8 EEA20939.1 - 2.2e-111 373.0 0.2 2.5e-111 372.8 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.18 EEA20940.1 - 6.1e-60 200.5 0.8 7.5e-60 200.2 0.8 1.1 1 0 0 1 1 1 1 Ribosomal S17 RPAP2_Rtr1 PF04181.13 EEA20941.1 - 6.9e-22 77.6 0.0 1.5e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Rtr1/RPAP2 family U3_snoRNA_assoc PF08297.11 EEA20941.1 - 0.0054 17.4 1.5 0.019 15.7 1.5 1.9 1 0 0 1 1 1 1 U3 snoRNA associated SH3_1 PF00018.28 EEA20942.1 - 1.7e-11 43.5 0.1 4.5e-11 42.2 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EEA20942.1 - 6.4e-09 35.4 0.0 1.3e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EEA20942.1 - 8.8e-09 35.1 0.1 1.7e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3464 PF11947.8 EEA20942.1 - 0.017 14.9 1.1 0.017 14.9 1.1 2.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 F-protein PF00469.20 EEA20942.1 - 0.68 9.5 5.2 0.2 11.2 1.6 1.9 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef DNA_pol_phi PF04931.13 EEA20942.1 - 3.6 5.6 12.0 6.4 4.8 12.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi SH3_1 PF00018.28 EEA20943.1 - 1.7e-11 43.5 0.1 4.5e-11 42.2 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EEA20943.1 - 6.4e-09 35.4 0.0 1.3e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EEA20943.1 - 8.8e-09 35.1 0.1 1.7e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3464 PF11947.8 EEA20943.1 - 0.017 14.9 1.1 0.017 14.9 1.1 2.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 F-protein PF00469.20 EEA20943.1 - 0.68 9.5 5.2 0.2 11.2 1.6 1.9 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef DNA_pol_phi PF04931.13 EEA20943.1 - 3.6 5.6 12.0 6.4 4.8 12.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi MFS_1 PF07690.16 EEA20944.1 - 4.6e-52 177.1 22.5 4.6e-52 177.1 22.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA20944.1 - 9.2e-08 31.4 11.4 9.2e-08 31.4 11.4 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter CPP1-like PF11833.8 EEA20944.1 - 0.23 11.1 5.8 0.65 9.6 5.8 1.8 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like OATP PF03137.20 EEA20944.1 - 3.2 5.9 11.5 0.26 9.5 3.1 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF1077 PF06417.12 EEA20945.1 - 3.4e-49 165.8 3.6 4.2e-49 165.5 3.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Adaptin_N PF01602.20 EEA20946.1 - 2.7e-115 385.9 6.3 3.5e-115 385.5 6.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EEA20946.1 - 1.8e-56 190.7 5.0 3.5e-55 186.5 0.6 3.3 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA20946.1 - 4.6e-13 49.4 4.1 0.0018 18.6 0.0 4.9 4 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 EEA20946.1 - 4.5e-09 35.8 5.0 0.11 12.8 0.0 5.5 7 0 0 7 7 7 3 HEAT repeat Atx10homo_assoc PF09759.9 EEA20946.1 - 0.0001 22.3 0.0 2.3 8.3 0.0 4.4 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 EEA20946.1 - 0.0027 17.7 1.3 1.3 9.1 0.0 4.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EEA20946.1 - 0.018 15.6 4.5 39 4.9 0.0 5.6 6 1 0 6 6 6 0 HEAT-like repeat TIP120 PF08623.10 EEA20946.1 - 0.025 14.4 1.8 1.9 8.2 0.1 3.0 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) T_hemolysin PF12261.8 EEA20946.1 - 0.035 13.9 0.0 0.9 9.3 0.0 2.3 2 0 0 2 2 2 0 Thermostable hemolysin Aminotran_5 PF00266.19 EEA20947.1 - 3.5e-07 29.5 0.1 1.6e-06 27.3 0.1 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EEA20947.1 - 0.032 12.8 0.0 0.073 11.6 0.0 1.4 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EEA20947.1 - 0.033 13.5 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Fe-S_biosyn PF01521.20 EEA20948.1 - 2.6e-12 46.9 0.0 6.7e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 Iron-sulphur cluster biosynthesis COX7C PF02935.16 EEA20949.1 - 0.031 14.5 1.0 2.2 8.6 0.0 2.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc MFS_1 PF07690.16 EEA20949.1 - 0.15 10.9 30.5 0.023 13.6 25.6 2.0 2 1 1 3 3 3 0 Major Facilitator Superfamily GrpB PF04229.14 EEA20950.1 - 3.3e-48 163.9 0.0 4.1e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 GrpB protein Paf67 PF10255.9 EEA20951.1 - 1.1e-160 535.1 0.0 1.3e-160 534.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EEA20951.1 - 0.028 14.5 0.0 0.16 12.2 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Paf1 PF03985.13 EEA20952.1 - 9e-51 173.2 0.0 1.3e-50 172.6 0.0 1.3 1 0 0 1 1 1 1 Paf1 LON_substr_bdg PF02190.16 EEA20953.1 - 5.4e-23 82.0 0.0 7.6e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_3 PF13920.6 EEA20953.1 - 6.3e-11 42.0 8.5 1.1e-10 41.2 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA20953.1 - 1.6e-09 37.4 12.8 9.7e-09 34.9 9.9 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA20953.1 - 1.5e-06 28.0 10.6 1.5e-06 28.0 10.6 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA20953.1 - 1.9e-06 28.1 10.9 1.9e-06 28.1 10.9 1.8 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.6 EEA20953.1 - 9.4e-06 25.4 9.4 2.2e-05 24.2 9.2 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EEA20953.1 - 1.9e-05 24.6 8.0 4e-05 23.5 6.1 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA20953.1 - 2.1e-05 24.4 9.7 4e-05 23.5 9.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 EEA20953.1 - 0.00086 19.1 9.0 0.00086 19.1 9.0 2.1 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EEA20953.1 - 0.0009 19.5 3.1 0.003 17.8 3.1 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EEA20953.1 - 0.0029 17.7 15.6 0.008 16.3 13.0 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EEA20953.1 - 0.041 14.0 8.2 0.081 13.1 8.2 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 CsgE PF10627.9 EEA20953.1 - 0.046 13.9 0.0 0.19 11.9 0.0 2.0 2 0 0 2 2 2 0 Curli assembly protein CsgE zf-P11 PF03854.14 EEA20953.1 - 0.46 10.2 7.7 1 9.1 7.7 1.6 1 0 0 1 1 1 0 P-11 zinc finger RICTOR_N PF14664.6 EEA20954.1 - 7.5e-128 426.7 2.3 8.2e-128 426.5 0.4 2.0 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 EEA20954.1 - 9.5e-39 132.1 0.2 1.5e-35 121.9 0.0 3.7 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EEA20954.1 - 8.3e-37 125.1 1.4 8.9e-34 115.4 0.3 4.7 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EEA20954.1 - 7.3e-28 96.6 2.6 2.2e-26 91.9 0.0 4.2 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 EEA20954.1 - 2.5e-16 59.5 8.6 5.6e-16 58.4 8.6 1.7 1 0 0 1 1 1 1 Hr1 repeat Uds1 PF15456.6 EEA20954.1 - 0.3 11.3 6.3 0.8 9.9 6.3 1.7 1 0 0 1 1 1 0 Up-regulated During Septation Arm PF00514.23 EEA20954.1 - 0.73 10.0 2.6 11 6.2 0.1 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Uricase PF01014.18 EEA20955.1 - 1.1e-80 268.3 1.8 2.3e-43 147.6 0.5 2.0 2 0 0 2 2 2 2 Uricase Mob_Pre PF01076.19 EEA20955.1 - 0.025 14.4 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Plasmid recombination enzyme DUF4825 PF16107.5 EEA20955.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) Ribosomal_L13 PF00572.18 EEA20956.1 - 3.7e-42 143.5 0.1 4.9e-42 143.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Ribosomal_S9 PF00380.19 EEA20957.1 - 1.5e-33 115.9 0.4 1.7e-33 115.7 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 AAR2 PF05282.11 EEA20958.1 - 1.2e-100 337.4 0.0 1.4e-100 337.1 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein GST_N_3 PF13417.6 EEA20959.1 - 1.4e-12 47.8 0.0 2.8e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA20959.1 - 1.6e-12 47.6 0.0 3.8e-12 46.4 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA20959.1 - 2.2e-10 40.7 0.0 4.2e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA20959.1 - 6.5e-09 35.9 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA20959.1 - 2.5e-08 34.0 0.0 4.6e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA20959.1 - 0.004 17.1 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EEA20959.1 - 0.057 13.7 0.1 0.14 12.5 0.0 1.6 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein Ribosomal_S11 PF00411.19 EEA20961.1 - 3.7e-46 156.0 1.0 4.6e-46 155.7 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EEA20961.1 - 0.068 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) PDH PF02153.17 EEA20962.1 - 1e-14 54.2 0.0 1.7e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 EEA20962.1 - 8.3e-07 29.5 0.0 1.7e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EEA20962.1 - 3.4e-06 27.3 0.0 5.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EEA20962.1 - 0.00013 21.6 0.0 0.00026 20.7 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 EEA20962.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA20962.1 - 0.0018 18.2 0.0 0.0033 17.3 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 EEA20962.1 - 0.045 14.0 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 EEA20962.1 - 0.091 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 EEA20962.1 - 0.17 11.7 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Rossmann-like domain Podoplanin PF05808.11 EEA20963.1 - 0.00055 20.1 0.2 0.00096 19.3 0.2 1.4 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.10 EEA20963.1 - 0.001 18.4 0.9 0.002 17.5 0.9 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 EEA20963.1 - 0.0018 17.8 0.2 0.0035 16.8 0.2 1.5 1 1 0 1 1 1 1 Cortical protein marker for cell polarity Cytomega_TRL10 PF06084.11 EEA20963.1 - 0.062 13.3 0.0 0.097 12.7 0.0 1.3 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein EphA2_TM PF14575.6 EEA20963.1 - 0.082 13.8 0.0 0.16 12.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EEA20963.1 - 0.1 12.5 1.2 0.26 11.2 1.2 1.7 1 1 0 1 1 1 0 TMEM154 protein family MSA-2c PF12238.8 EEA20963.1 - 1.3 9.0 5.9 3.3 7.7 5.9 1.6 1 0 0 1 1 1 0 Merozoite surface antigen 2c Podoplanin PF05808.11 EEA20964.1 - 0.00057 20.0 0.2 0.00096 19.3 0.2 1.4 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.10 EEA20964.1 - 0.00091 18.6 0.9 0.0022 17.3 0.9 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 EEA20964.1 - 0.0021 17.5 0.1 0.004 16.6 0.1 1.5 1 1 0 1 1 1 1 Cortical protein marker for cell polarity TMEM154 PF15102.6 EEA20964.1 - 0.054 13.4 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 EEA20964.1 - 0.086 13.7 0.0 0.19 12.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MSA-2c PF12238.8 EEA20964.1 - 1.8 8.5 5.9 3.7 7.5 5.9 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c Catalase PF00199.19 EEA20965.1 - 6.2e-196 651.0 0.2 8.1e-196 650.6 0.2 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EEA20965.1 - 1.6e-09 37.8 0.0 4.6e-09 36.3 0.0 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive DUF3974 PF13120.6 EEA20965.1 - 0.14 12.3 0.3 0.85 9.7 0.0 2.4 3 1 1 4 4 4 0 Domain of unknown function (DUF3974) ECH_1 PF00378.20 EEA20966.1 - 4.3e-77 258.8 0.0 5e-77 258.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA20966.1 - 9e-37 127.3 0.1 6.6e-36 124.5 0.1 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase TetR_C_33 PF13305.6 EEA20966.1 - 0.058 14.1 0.0 0.1 13.4 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Peptidase_S49 PF01343.18 EEA20966.1 - 0.099 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase family S49 Rer1 PF03248.13 EEA20967.1 - 1e-80 269.5 5.2 1.2e-80 269.2 5.2 1.0 1 0 0 1 1 1 1 Rer1 family DUF962 PF06127.11 EEA20967.1 - 0.16 12.0 2.7 5.2 7.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF962) Rer1 PF03248.13 EEA20968.1 - 2.3e-64 216.3 5.3 3e-64 215.9 5.3 1.1 1 0 0 1 1 1 1 Rer1 family DUF962 PF06127.11 EEA20968.1 - 0.17 12.0 2.4 5.8 7.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF962) Actin PF00022.19 EEA20969.1 - 2e-28 99.1 0.0 5.2e-18 64.8 0.0 2.6 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EEA20969.1 - 6e-07 28.6 0.0 0.0012 17.8 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Actin_micro PF17003.5 EEA20969.1 - 0.0003 20.1 0.4 0.032 13.4 0.1 2.2 2 0 0 2 2 2 2 Putative actin-like family FtsA PF14450.6 EEA20969.1 - 0.02 15.3 0.0 0.11 12.9 0.0 2.3 2 1 0 2 2 2 0 Cell division protein FtsA DUF2114 PF09887.9 EEA20969.1 - 0.14 10.6 0.1 0.2 10.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2114) DUF4106 PF13388.6 EEA20969.1 - 3.2 6.9 7.6 5.3 6.2 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Arf PF00025.21 EEA20970.1 - 3.5e-73 244.8 0.1 4.3e-73 244.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA20970.1 - 1.5e-13 51.0 0.0 2e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EEA20970.1 - 2.6e-11 43.3 0.0 3.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EEA20970.1 - 3.2e-10 39.9 0.0 3.8e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EEA20970.1 - 2.9e-09 36.6 0.2 4.3e-05 22.8 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EEA20970.1 - 6e-08 32.3 0.0 7.9e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA20970.1 - 5.4e-06 26.5 0.0 9.6e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA20970.1 - 0.00058 19.5 0.0 0.046 13.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EEA20970.1 - 0.0089 15.6 0.6 0.039 13.5 0.6 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF3419 PF11899.8 EEA20971.1 - 5e-158 526.3 0.0 6.7e-158 525.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EEA20971.1 - 1.8e-11 44.1 0.0 6.5e-10 39.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA20971.1 - 4.2e-09 37.0 0.0 3e-08 34.3 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA20971.1 - 6.8e-09 36.4 0.0 4.4e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA20971.1 - 3.9e-08 32.9 0.0 7.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EEA20971.1 - 4.5e-08 33.0 0.0 1.2e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA20971.1 - 1.2e-05 25.8 0.0 6.4e-05 23.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Xan_ur_permease PF00860.20 EEA20971.1 - 0.086 11.5 0.1 0.13 10.9 0.1 1.1 1 0 0 1 1 1 0 Permease family Mab-21 PF03281.14 EEA20971.1 - 0.11 11.7 0.0 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 Mab-21 protein TSC22 PF01166.18 EEA20972.1 - 0.078 13.3 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family Corona_M PF01635.18 EEA20972.1 - 0.16 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein Lipase_3 PF01764.25 EEA20973.1 - 8.5e-06 25.7 0.0 3.1e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 EEA20973.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 UPF0227 PF05728.12 EEA20973.1 - 0.25 11.3 0.0 0.4 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) RNA_pol_I_TF PF04090.12 EEA20974.1 - 5.3e-10 39.1 0.0 1e-06 28.4 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase I specific initiation factor ECM11 PF15463.6 EEA20975.1 - 4.2e-49 166.5 0.0 3.7e-48 163.5 0.0 2.6 2 0 0 2 2 2 1 Extracellular mutant protein 11 VPS9 PF02204.18 EEA20976.1 - 7e-28 96.9 0.0 1.2e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain zf-RING_2 PF13639.6 EEA20977.1 - 1e-12 48.2 5.1 1.6e-12 47.6 5.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EEA20977.1 - 1.2e-09 38.3 2.8 2.3e-09 37.4 2.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EEA20977.1 - 1.6e-08 34.2 4.6 2.6e-08 33.5 4.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA20977.1 - 9.9e-08 31.7 4.8 1.5e-07 31.1 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA20977.1 - 8.3e-07 28.6 1.7 1.5e-06 27.8 1.7 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EEA20977.1 - 5.1e-06 26.4 3.3 7.6e-06 25.8 3.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA20977.1 - 7.5e-05 22.5 2.4 0.00013 21.8 2.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EEA20977.1 - 0.00018 21.1 2.5 0.00028 20.4 2.5 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EEA20977.1 - 0.00036 20.3 2.9 0.00059 19.6 2.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA20977.1 - 0.00039 20.4 2.3 0.00077 19.5 2.3 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EEA20977.1 - 0.00086 19.3 4.0 0.0018 18.3 4.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger RINGv PF12906.7 EEA20977.1 - 0.0054 16.8 5.7 0.0085 16.2 5.7 1.3 1 0 0 1 1 1 1 RING-variant domain zf-Nse PF11789.8 EEA20977.1 - 0.016 15.0 1.5 0.035 13.9 1.5 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3H2C3 PF17122.5 EEA20977.1 - 0.039 14.0 2.2 0.076 13.1 2.2 1.4 1 0 0 1 1 1 0 Zinc-finger zf-C3HC4_5 PF17121.5 EEA20977.1 - 0.093 12.6 1.1 0.18 11.7 1.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EEA20977.1 - 0.26 11.5 3.5 0.48 10.6 3.5 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 EEA20977.1 - 0.28 11.1 4.8 0.2 11.6 3.0 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 EEA20977.1 - 0.47 10.4 4.5 0.76 9.7 4.5 1.3 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EEA20977.1 - 0.71 10.2 2.9 1.3 9.4 2.9 1.3 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 EEA20977.1 - 1.5 8.7 4.1 2.4 8.0 4.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Formyl_trans_N PF00551.19 EEA20978.1 - 3.1e-35 121.5 0.0 3.6e-35 121.3 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase Fungal_trans_2 PF11951.8 EEA20979.1 - 6.8e-20 71.2 2.3 1.3e-19 70.3 2.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA20979.1 - 2.2e-07 30.9 12.4 2.2e-07 30.9 12.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 EEA20979.1 - 1 7.8 6.9 1.4 7.4 6.9 1.2 1 0 0 1 1 1 0 Macoilin family DEAD PF00270.29 EEA20980.1 - 5.5e-27 94.7 0.0 9.6e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EEA20980.1 - 5.7e-17 62.3 0.1 2.9e-12 47.1 0.1 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EEA20980.1 - 2.3e-12 47.2 0.1 1e-11 45.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA20980.1 - 2.1e-06 27.8 0.0 3.7e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 EEA20980.1 - 5.8e-06 26.7 0.0 1.2e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor CDT1 like NUDE_C PF04880.13 EEA20980.1 - 9 6.7 9.9 40 4.6 0.6 3.3 3 0 0 3 3 3 0 NUDE protein, C-terminal conserved region HDV_ag PF01517.18 EEA20981.1 - 0.0084 15.9 1.4 0.018 14.8 1.4 1.5 1 0 0 1 1 1 1 Hepatitis delta virus delta antigen FOXP-CC PF16159.5 EEA20981.1 - 0.12 13.0 0.9 0.25 12.0 0.7 1.6 1 1 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 EEA20981.1 - 0.13 12.8 0.2 0.3 11.6 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type YabA PF06156.13 EEA20981.1 - 7 7.3 8.0 2.8 8.6 0.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA HDV_ag PF01517.18 EEA20982.1 - 0.009 15.8 1.4 0.019 14.8 1.4 1.5 1 0 0 1 1 1 1 Hepatitis delta virus delta antigen zf-C2H2 PF00096.26 EEA20982.1 - 0.14 12.7 0.2 0.31 11.6 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 EEA20982.1 - 0.14 12.8 1.0 0.28 11.9 0.8 1.6 1 1 0 1 1 1 0 FOXP coiled-coil domain YabA PF06156.13 EEA20982.1 - 7.7 7.2 8.0 2.9 8.6 0.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA HDV_ag PF01517.18 EEA20983.1 - 0.0077 16.1 1.5 0.013 15.3 1.5 1.4 1 0 0 1 1 1 1 Hepatitis delta virus delta antigen FOXP-CC PF16159.5 EEA20983.1 - 0.1 13.2 0.9 0.19 12.3 0.7 1.6 1 1 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 EEA20983.1 - 0.14 12.7 0.2 0.24 11.9 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type YabA PF06156.13 EEA20983.1 - 5.4 7.7 8.2 2.4 8.9 0.2 2.1 1 1 1 2 2 2 0 Initiation control protein YabA HDV_ag PF01517.18 EEA20984.1 - 0.0081 16.0 1.4 0.015 15.1 1.4 1.4 1 0 0 1 1 1 1 Hepatitis delta virus delta antigen FOXP-CC PF16159.5 EEA20984.1 - 0.15 12.7 1.2 0.28 11.9 1.1 1.6 1 1 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 EEA20984.1 - 0.15 12.6 0.2 0.26 11.8 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type YabA PF06156.13 EEA20984.1 - 6.4 7.5 8.2 2.6 8.7 0.2 2.1 1 1 1 2 2 2 0 Initiation control protein YabA HDV_ag PF01517.18 EEA20985.1 - 0.0077 16.1 1.5 0.013 15.3 1.5 1.4 1 0 0 1 1 1 1 Hepatitis delta virus delta antigen FOXP-CC PF16159.5 EEA20985.1 - 0.1 13.2 0.9 0.19 12.3 0.7 1.6 1 1 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 EEA20985.1 - 0.14 12.7 0.2 0.24 11.9 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type YabA PF06156.13 EEA20985.1 - 5.4 7.7 8.2 2.4 8.9 0.2 2.1 1 1 1 2 2 2 0 Initiation control protein YabA DEAD PF00270.29 EEA20986.1 - 2.1e-49 167.7 0.0 6.7e-48 162.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA20986.1 - 9.6e-32 109.6 0.0 3.1e-31 108.0 0.0 1.9 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA20986.1 - 0.00053 20.0 0.0 0.0017 18.4 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EEA20986.1 - 0.0057 15.5 0.0 0.33 9.7 0.0 2.3 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 EEA20986.1 - 0.0059 17.0 0.0 1.7 9.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain ERCC3_RAD25_C PF16203.5 EEA20986.1 - 0.0061 15.8 0.1 0.0089 15.3 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF5335 PF17269.2 EEA20986.1 - 0.073 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5335) DUF2443 PF10398.9 EEA20986.1 - 0.091 12.8 0.4 0.19 11.8 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) POTRA_2 PF08479.11 EEA20986.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 POTRA domain, ShlB-type PPR_2 PF13041.6 EEA20987.1 - 2.5e-17 62.8 0.1 2.1e-14 53.5 0.0 3.2 3 0 0 3 3 3 2 PPR repeat family PPR_long PF17177.4 EEA20987.1 - 8.5e-06 25.3 0.0 1.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EEA20987.1 - 0.0011 19.0 0.0 0.6 10.2 0.0 2.7 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR PF01535.20 EEA20987.1 - 0.029 14.6 4.3 3.9 7.9 0.0 3.7 3 0 0 3 3 3 0 PPR repeat PPR_1 PF12854.7 EEA20987.1 - 0.056 13.1 0.1 0.3 10.8 0.0 2.3 3 0 0 3 3 3 0 PPR repeat Yip1 PF04893.17 EEA20988.1 - 2.3e-13 50.2 18.6 5e-13 49.1 18.6 1.6 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 EEA20988.1 - 0.034 13.9 6.0 0.05 13.4 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) Ran_BP1 PF00638.18 EEA20989.1 - 7e-19 68.3 0.0 1.6e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 RanBP1 domain Phos_pyr_kin PF08543.12 EEA20990.1 - 7.3e-81 271.2 2.7 1e-80 270.7 2.7 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EEA20990.1 - 6.2e-53 179.7 0.1 8.9e-53 179.2 0.1 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 EEA20990.1 - 1.8e-06 27.5 0.8 2.2e-05 23.9 0.8 2.1 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 EEA20990.1 - 0.00038 19.9 0.5 0.0055 16.1 0.1 2.3 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family Carb_kinase PF01256.17 EEA20990.1 - 0.0031 17.0 1.0 0.0064 16.0 1.0 1.5 1 0 0 1 1 1 1 Carbohydrate kinase CbiK PF06180.11 EEA20990.1 - 0.15 11.3 0.1 0.38 10.0 0.1 1.6 1 0 0 1 1 1 0 Cobalt chelatase (CbiK) DNA_pol_B PF00136.21 EEA20991.1 - 1.2e-119 400.1 3.8 1.8e-119 399.5 3.8 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EEA20991.1 - 3e-69 232.5 0.4 7.1e-69 231.3 0.4 1.7 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EEA20991.1 - 1.3e-42 146.2 0.0 2.3e-42 145.3 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EEA20991.1 - 1.8e-25 88.8 7.0 1.8e-25 88.8 7.0 3.4 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EEA20991.1 - 0.0022 16.9 0.0 0.0064 15.4 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral RVT_2 PF07727.14 EEA20992.1 - 8.9e-37 127.0 0.0 1.5e-36 126.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA20992.1 - 3.5e-09 36.9 0.0 9.8e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EEA20992.1 - 8.8e-09 35.1 0.1 1.7e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain TetR_C_31 PF17940.1 EEA20992.1 - 0.017 15.3 0.0 0.086 13.1 0.0 2.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Flg_hook PF02120.16 EEA20992.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK DUF5012 PF16404.5 EEA20993.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5012) Sulfotransfer_4 PF17784.1 EEA20993.1 - 0.67 9.7 7.1 1.6 8.5 6.6 2.1 1 1 1 2 2 2 0 Sulfotransferase domain Myb_DNA-bind_5 PF13873.6 EEA20993.1 - 9.9 6.3 10.0 21 5.3 1.1 3.2 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain LRR_4 PF12799.7 EEA20994.1 - 0.002 18.5 1.1 32 5.1 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) HHH_5 PF14520.6 EEA20994.1 - 0.0048 17.5 0.6 0.016 15.8 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain Rad9 PF04139.13 EEA20995.1 - 3.5e-52 177.3 0.6 4.2e-52 177.1 0.6 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EEA20995.1 - 8.9e-08 31.5 1.2 6.5e-07 28.7 0.6 2.4 1 1 1 2 2 2 1 Repair protein Rad1/Rec1/Rad17 RCC1 PF00415.18 EEA20996.1 - 2.7e-27 95.2 18.7 8e-08 32.8 0.0 7.8 6 3 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA20996.1 - 1.5e-21 75.6 19.4 5.3e-07 29.3 0.1 6.4 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EEA20996.1 - 2.7 8.3 4.4 3.4 8.0 0.0 3.0 4 0 0 4 4 4 0 Putative heavy-metal chelation Sugar_tr PF00083.24 EEA20997.1 - 1.1e-22 80.5 20.1 7.1e-20 71.3 20.1 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA20997.1 - 2.7e-05 23.3 34.3 0.00082 18.4 10.8 2.8 1 1 2 3 3 3 3 Major Facilitator Superfamily Pkinase PF00069.25 EEA20998.1 - 3.4e-70 236.4 0.0 4.4e-70 236.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA20998.1 - 2.9e-34 118.5 0.0 4.2e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EEA20998.1 - 3.9e-10 40.3 0.1 1e-09 39.0 0.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EEA20998.1 - 3.3e-07 29.6 0.1 5.1e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EEA20998.1 - 0.0074 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C2 PF00168.30 EEA20998.1 - 0.057 13.7 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 C2 domain FTA2 PF13095.6 EEA20998.1 - 0.058 13.0 0.1 0.52 9.9 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Dcc1 PF09724.9 EEA20998.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 ZZ PF00569.17 EEA20999.1 - 3.8e-10 39.4 4.1 7.6e-10 38.5 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 EEA20999.1 - 5.1e-10 39.4 0.0 1.3e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 EEA20999.1 - 7.7e-09 35.8 0.7 2.6e-08 34.1 0.0 2.2 3 0 0 3 3 3 1 SWIRM domain SHOCT PF09851.9 EEA20999.1 - 0.04 13.7 1.7 0.15 11.9 1.7 2.1 1 0 0 1 1 1 0 Short C-terminal domain Mannitol_dh_C PF08125.13 EEA21000.1 - 5e-45 153.9 0.1 8.7e-45 153.1 0.1 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain DIOX_N PF14226.6 EEA21000.1 - 2.5e-26 92.7 0.0 6.7e-25 88.1 0.0 2.4 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA21000.1 - 5.8e-21 74.9 0.0 1.5e-20 73.5 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Mannitol_dh PF01232.23 EEA21000.1 - 3.4e-18 66.3 0.2 1.4e-17 64.2 0.0 2.0 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain 3HCDH_N PF02737.18 EEA21000.1 - 0.01 15.7 0.5 0.054 13.4 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EEA21000.1 - 0.012 15.2 0.2 0.032 13.8 0.2 1.8 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EEA21000.1 - 0.02 15.2 1.6 2 8.7 0.1 2.8 2 1 0 2 2 2 0 TrkA-N domain Pyr_redox_2 PF07992.14 EEA21000.1 - 0.1 11.8 0.2 0.18 11.0 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_23 PF13489.6 EEA21000.1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SUR7 PF06687.12 EEA21001.1 - 3.2e-27 95.5 9.0 3.8e-27 95.3 9.0 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EEA21001.1 - 4.7 7.1 13.8 0.21 11.5 6.0 2.0 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Coatomer_WDAD PF04053.14 EEA21002.1 - 1.4e-171 571.5 0.0 6.6e-171 569.2 0.0 1.9 2 1 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EEA21002.1 - 9.1e-38 127.6 7.3 1e-05 26.2 0.0 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA21002.1 - 1.1e-08 35.2 0.4 3.4 8.0 0.1 6.2 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA21002.1 - 1.5e-05 23.9 3.2 0.2 10.3 0.1 4.2 1 1 2 4 4 4 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EEA21002.1 - 0.011 15.8 0.0 5.4 7.1 0.0 3.6 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, middle region MetallophosC PF16370.5 EEA21002.1 - 0.055 13.7 0.1 0.22 11.7 0.0 2.0 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase ETC_C1_NDUFA5 PF04716.14 EEA21003.1 - 4.1e-29 100.2 1.7 3.2e-26 90.9 0.0 2.3 2 0 0 2 2 2 2 ETC complex I subunit conserved region Ku_PK_bind PF08785.11 EEA21003.1 - 0.0064 16.6 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 Ku C terminal domain like Thioredoxin PF00085.20 EEA21004.1 - 1.3e-43 147.2 0.0 2.7e-24 85.1 0.0 4.5 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 EEA21004.1 - 8.4e-14 51.9 0.0 0.00013 21.9 0.0 4.5 4 1 1 5 5 5 4 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EEA21004.1 - 6.2e-05 23.4 1.1 1.2 9.6 0.3 3.9 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EEA21004.1 - 0.00076 19.8 0.1 3.2 8.1 0.0 4.2 3 1 1 4 4 4 1 Thioredoxin-like HyaE PF07449.11 EEA21004.1 - 0.0017 18.3 0.0 0.24 11.4 0.0 3.0 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 EEA21004.1 - 0.044 14.0 1.5 0.25 11.6 0.1 2.8 3 0 0 3 3 3 0 Thioredoxin-like Calsequestrin PF01216.17 EEA21004.1 - 0.14 11.2 1.1 0.27 10.2 0.3 1.8 2 0 0 2 2 2 0 Calsequestrin Thioredoxin_3 PF13192.6 EEA21004.1 - 0.15 12.2 0.1 6.1 7.0 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin domain Fungus-induced PF10917.8 EEA21004.1 - 0.83 10.0 4.7 0.13 12.6 0.7 1.7 1 1 1 2 2 2 0 Fungus-induced protein TraF PF13728.6 EEA21004.1 - 3.1 7.5 8.1 14 5.5 0.0 3.6 4 0 0 4 4 4 0 F plasmid transfer operon protein AA_permease_2 PF13520.6 EEA21005.1 - 2e-69 234.5 48.7 2.3e-69 234.3 48.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA21005.1 - 3.3e-18 65.5 35.3 4.6e-18 65.1 35.3 1.2 1 0 0 1 1 1 1 Amino acid permease QCR10 PF09796.9 EEA21006.1 - 2e-22 79.0 0.4 2.2e-22 78.9 0.4 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) QCR10 PF09796.9 EEA21007.1 - 5e-25 87.3 1.1 6.7e-25 86.9 1.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) QCR10 PF09796.9 EEA21008.1 - 2e-22 79.0 0.4 2.2e-22 78.9 0.4 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Zn_clus PF00172.18 EEA21009.1 - 5.9e-06 26.3 8.1 1e-05 25.5 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF676 PF05057.14 EEA21010.1 - 0.0001 21.9 0.0 0.00022 20.8 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EEA21010.1 - 0.003 17.3 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_8 PF06259.12 EEA21010.1 - 0.057 13.0 0.1 0.093 12.4 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase LCAT PF02450.15 EEA21010.1 - 0.076 12.2 0.0 0.091 11.9 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EEA21010.1 - 0.098 13.2 0.0 0.13 12.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family GRP PF07172.11 EEA21010.1 - 0.13 12.9 10.6 0.26 12.0 10.6 1.4 1 0 0 1 1 1 0 Glycine rich protein family NACHT PF05729.12 EEA21011.1 - 0.006 16.5 0.0 4.2 7.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_16 PF13191.6 EEA21011.1 - 0.14 12.5 0.1 0.84 10.0 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain zf-H2C2_2 PF13465.6 EEA21012.1 - 1.2e-05 25.5 1.4 1.2e-05 25.5 1.4 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-Di19 PF05605.12 EEA21012.1 - 0.00021 21.5 4.4 0.00036 20.8 4.4 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EEA21012.1 - 0.00026 21.6 15.2 0.023 15.5 5.9 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA21012.1 - 0.033 14.6 14.7 0.14 12.7 7.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EEA21012.1 - 0.049 13.9 4.0 3.3 8.1 0.8 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn_clus PF00172.18 EEA21013.1 - 1.1e-13 51.1 25.1 2.8e-09 36.9 8.4 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA21013.1 - 2.3e-08 33.4 0.0 4.2e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sulfatase PF00884.23 EEA21014.1 - 5e-42 144.4 0.0 6.9e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 EEA21014.1 - 6.6e-05 21.7 0.0 9.4e-05 21.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 EEA21014.1 - 0.0001 22.5 0.1 0.0004 20.6 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EEA21014.1 - 0.004 16.8 0.3 0.14 11.8 0.3 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase MFS_1 PF07690.16 EEA21015.1 - 2.1e-40 138.7 47.9 2.1e-40 138.7 47.9 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA21015.1 - 4.8e-12 45.5 14.8 4.8e-12 45.5 14.8 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter Zn_clus PF00172.18 EEA21016.1 - 3.7e-06 26.9 8.6 9.6e-06 25.6 8.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHO_dh PF01180.21 EEA21017.1 - 1.4e-65 221.4 0.1 1.8e-65 221.0 0.1 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase PcrB PF01884.17 EEA21017.1 - 0.004 16.7 0.1 2.6 7.4 0.0 2.3 2 0 0 2 2 2 2 PcrB family Ribul_P_3_epim PF00834.19 EEA21017.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family NMO PF03060.15 EEA21017.1 - 0.059 12.7 0.7 0.091 12.1 0.1 1.6 2 0 0 2 2 2 0 Nitronate monooxygenase LVIVD PF08309.11 EEA21017.1 - 0.14 11.5 1.2 10 5.5 0.0 2.5 2 0 0 2 2 2 0 LVIVD repeat TIM PF00121.18 EEA21018.1 - 3.6e-41 141.1 0.0 4.6e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Triosephosphate isomerase DUF1921 PF09081.10 EEA21018.1 - 0.023 14.9 0.0 0.051 13.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1921) LacAB_rpiB PF02502.18 EEA21019.1 - 1e-41 142.2 0.0 1.2e-41 142.0 0.0 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Gly_rich_SFCGS PF14272.6 EEA21019.1 - 0.073 13.1 0.1 0.14 12.2 0.0 1.6 1 1 0 1 1 1 0 Glycine-rich SFCGS U-box PF04564.15 EEA21020.1 - 3.2e-21 75.3 0.0 5.8e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 U-box domain TPR_2 PF07719.17 EEA21020.1 - 2.7e-08 33.3 0.6 0.00069 19.5 0.0 4.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA21020.1 - 2.6e-07 30.2 0.2 0.00015 21.4 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA21020.1 - 3.1e-07 30.9 4.6 0.037 14.7 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA21020.1 - 3.3e-05 23.5 0.0 0.00022 20.8 0.0 2.2 2 0 0 2 2 2 1 TPR repeat CHIP_TPR_N PF18391.1 EEA21020.1 - 8.2e-05 23.3 4.4 0.00016 22.3 4.4 1.5 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_12 PF13424.6 EEA21020.1 - 0.00013 22.2 2.5 0.89 9.9 0.0 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA21020.1 - 0.00032 21.3 4.7 0.32 11.9 0.0 3.5 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA21020.1 - 0.00053 20.4 7.9 0.0065 17.0 0.0 3.1 3 1 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA21020.1 - 0.011 15.9 0.1 0.98 9.7 0.2 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EEA21020.1 - 0.014 15.6 2.9 0.094 13.0 0.1 3.3 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EEA21020.1 - 0.016 15.3 0.1 0.067 13.4 0.0 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 EEA21020.1 - 0.021 15.2 0.2 1.6 9.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EEA21020.1 - 0.041 13.9 2.7 8.2 6.7 0.0 4.0 4 1 0 4 4 3 0 Tetratricopeptide repeat GlnD_UR_UTase PF08335.11 EEA21020.1 - 0.045 13.9 1.5 0.068 13.3 1.5 1.3 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase GvpG PF05120.12 EEA21020.1 - 0.052 13.6 0.9 0.13 12.2 0.9 1.7 1 0 0 1 1 1 0 Gas vesicle protein G zf-NOSIP PF15906.5 EEA21020.1 - 0.057 13.6 0.0 0.12 12.5 0.0 1.6 1 1 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 EEA21020.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit CdvA PF18822.1 EEA21020.1 - 0.094 12.5 6.1 0.72 9.7 1.8 2.5 2 1 1 3 3 3 0 CdvA-like coiled-coil domain HTH_WhiA PF02650.14 EEA21020.1 - 0.11 12.8 2.0 0.21 12.0 2.0 1.5 1 0 0 1 1 1 0 WhiA C-terminal HTH domain TPR_10 PF13374.6 EEA21020.1 - 0.3 11.0 3.4 1.5 8.8 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Phasin_2 PF09361.10 EEA21020.1 - 0.87 9.9 9.1 0.13 12.5 4.7 1.9 2 0 0 2 2 2 0 Phasin protein ADH_N PF08240.12 EEA21021.1 - 3.5e-20 71.9 1.6 5.9e-20 71.2 1.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA21021.1 - 2e-19 69.8 0.0 4.6e-19 68.7 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA21021.1 - 1.7e-08 35.6 0.0 3.4e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA21021.1 - 1.9e-07 30.8 0.0 3.3e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus OapA PF04225.12 EEA21021.1 - 0.098 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Opacity-associated protein A LysM-like domain ACBP PF00887.19 EEA21022.1 - 1.6e-22 79.5 3.3 1.8e-22 79.3 3.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 EEA21022.1 - 0.013 15.9 0.3 0.13 12.7 0.1 1.9 1 1 0 2 2 2 0 FERM central domain ACBP PF00887.19 EEA21023.1 - 1.6e-22 79.5 3.3 1.8e-22 79.3 3.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 EEA21023.1 - 0.013 15.9 0.3 0.13 12.7 0.1 1.9 1 1 0 2 2 2 0 FERM central domain Tyr-DNA_phospho PF06087.12 EEA21024.1 - 8.2e-170 565.3 0.0 9.5e-170 565.1 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EEA21024.1 - 0.00027 20.9 0.1 0.16 11.9 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain DUF2271 PF10029.9 EEA21024.1 - 0.021 14.4 0.7 0.058 13.0 0.3 1.9 2 0 0 2 2 2 0 Predicted periplasmic protein (DUF2271) NACHT PF05729.12 EEA21025.1 - 4.3e-09 36.5 0.2 1.5e-08 34.7 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EEA21025.1 - 1.8e-08 35.0 0.0 3e-07 31.0 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EEA21025.1 - 1.3e-05 25.5 0.0 4.5e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EEA21025.1 - 0.00023 21.5 0.1 0.0053 17.1 0.0 2.7 2 1 1 3 3 3 1 RNA helicase KAP_NTPase PF07693.14 EEA21025.1 - 0.0026 17.1 0.2 0.57 9.4 0.1 2.7 2 0 0 2 2 2 1 KAP family P-loop domain NB-ARC PF00931.22 EEA21025.1 - 0.022 14.0 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Ank_2 PF12796.7 EEA21025.1 - 0.029 15.0 0.0 0.094 13.3 0.0 1.9 2 0 0 2 2 1 0 Ankyrin repeats (3 copies) DUF2075 PF09848.9 EEA21025.1 - 0.042 13.1 0.0 0.095 11.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EEA21025.1 - 0.047 13.6 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Ank_5 PF13857.6 EEA21025.1 - 0.051 13.9 0.0 0.78 10.1 0.0 2.6 1 1 0 1 1 1 0 Ankyrin repeats (many copies) AAA PF00004.29 EEA21025.1 - 0.088 13.2 0.0 0.33 11.4 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Goodbye PF17109.5 EEA21025.1 - 0.13 12.7 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain Goodbye PF17109.5 EEA21026.1 - 0.00016 22.1 0.0 0.00021 21.7 0.0 1.2 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain NACHT PF05729.12 EEA21027.1 - 4.2e-09 36.5 0.0 8e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA21027.1 - 3.6e-05 24.2 0.0 9.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Ank_2 PF12796.7 EEA21027.1 - 5.3e-05 23.7 0.8 0.08 13.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) ATPase_2 PF01637.18 EEA21027.1 - 0.00098 19.1 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EEA21027.1 - 0.001 19.4 0.0 0.0026 18.1 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Ank_5 PF13857.6 EEA21027.1 - 0.002 18.4 0.4 0.2 12.0 0.1 3.4 2 1 0 2 2 2 1 Ankyrin repeats (many copies) PhoH PF02562.16 EEA21027.1 - 0.017 14.6 0.0 0.3 10.5 0.0 2.5 3 0 0 3 3 3 0 PhoH-like protein Ank PF00023.30 EEA21027.1 - 0.02 15.3 1.7 1.1 9.8 1.3 3.7 3 1 0 3 3 3 0 Ankyrin repeat NB-ARC PF00931.22 EEA21027.1 - 0.02 14.1 0.0 0.07 12.3 0.0 1.9 1 1 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 EEA21027.1 - 0.028 14.7 0.0 0.073 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EEA21027.1 - 0.029 13.6 0.2 0.25 10.5 0.0 2.1 2 0 0 2 2 2 0 KAP family P-loop domain IstB_IS21 PF01695.17 EEA21027.1 - 0.03 14.1 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.6 EEA21027.1 - 0.031 14.6 0.0 0.083 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EEA21027.1 - 0.07 12.2 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EEA21027.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EEA21027.1 - 0.079 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EEA21027.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 EEA21027.1 - 0.12 11.8 0.0 0.44 9.9 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 EEA21027.1 - 0.12 11.6 0.2 0.25 10.5 0.0 1.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) Ank_3 PF13606.6 EEA21027.1 - 0.13 12.9 0.9 87 4.2 0.1 4.1 3 1 0 3 3 3 0 Ankyrin repeat DIE2_ALG10 PF04922.12 EEA21028.1 - 6.1e-123 411.0 4.4 1e-122 410.3 4.4 1.4 1 0 0 1 1 1 1 DIE2/ALG10 family SDA1 PF05285.12 EEA21028.1 - 0.051 13.0 6.8 0.071 12.5 6.8 1.1 1 0 0 1 1 1 0 SDA1 DUF4674 PF15719.5 EEA21028.1 - 0.22 11.5 7.9 0.34 10.9 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Phage_Gp23 PF10669.9 EEA21028.1 - 6.4 7.1 7.0 9.4 6.6 4.4 2.2 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Sld5 PF05916.11 EEA21029.1 - 1.1e-31 109.5 0.0 5.1e-31 107.4 0.0 2.0 2 1 0 2 2 2 1 GINS complex protein CUE PF02845.16 EEA21030.1 - 1.1e-10 40.9 0.0 1.9e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 EEA21030.1 - 0.013 15.1 9.1 0.031 13.9 9.1 1.6 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) DUF1151 PF06625.11 EEA21030.1 - 0.036 14.0 2.9 0.054 13.4 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) SMC_N PF02463.19 EEA21031.1 - 1e-69 234.4 4.3 6.3e-69 231.8 4.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA21031.1 - 7.7e-21 74.6 0.4 4.6e-20 72.1 0.1 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EEA21031.1 - 3.2e-11 44.1 13.8 3.2e-11 44.1 13.8 6.6 2 2 4 6 6 6 1 AAA domain AAA_21 PF13304.6 EEA21031.1 - 8e-10 39.0 7.9 0.0002 21.2 0.2 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EEA21031.1 - 7.8e-05 22.5 16.9 7.8e-05 22.5 16.9 4.5 2 2 2 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 EEA21031.1 - 0.00013 21.6 0.1 0.00032 20.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain HSBP1 PF06825.12 EEA21031.1 - 0.31 10.9 17.7 0.27 11.1 0.5 5.2 5 0 0 5 5 5 0 Heat shock factor binding protein 1 VPS11_C PF12451.8 EEA21031.1 - 5.9 7.2 14.2 1.7 8.9 3.3 4.1 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal NOT2_3_5 PF04153.18 EEA21032.1 - 8.3e-28 97.1 0.8 2.2e-27 95.7 0.0 1.9 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family MRP-L47 PF06984.13 EEA21033.1 - 1.7e-18 66.5 1.3 3.8e-18 65.4 0.0 2.0 1 1 1 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GDI PF00996.18 EEA21034.1 - 4.1e-193 641.8 0.0 4.8e-193 641.6 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EEA21034.1 - 0.0089 16.2 0.0 0.023 14.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA21034.1 - 0.014 15.9 0.4 0.45 11.1 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 4HBT PF03061.22 EEA21035.1 - 6.5e-12 45.6 0.0 9.2e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EEA21035.1 - 0.00013 22.4 0.2 0.0025 18.1 0.0 2.0 1 1 1 2 2 2 2 Thioesterase-like superfamily DUF3662 PF12401.8 EEA21035.1 - 0.03 14.7 0.0 0.052 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) ORC4_C PF14629.6 EEA21036.1 - 9.9e-48 162.4 0.0 1.6e-47 161.7 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EEA21036.1 - 5.8e-16 59.3 0.1 2.6e-15 57.2 0.1 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EEA21036.1 - 2.7e-07 30.9 0.0 6.4e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EEA21036.1 - 3.6e-07 30.2 0.9 8.2e-07 29.1 0.2 1.9 2 1 0 2 2 2 1 NACHT domain AAA PF00004.29 EEA21036.1 - 6.5e-07 29.8 0.0 2e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EEA21036.1 - 5.2e-06 25.8 0.0 8.6e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 EEA21036.1 - 0.00015 21.8 0.0 0.00028 20.9 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EEA21036.1 - 0.0003 20.1 0.1 0.00078 18.8 0.0 1.5 1 1 0 1 1 1 1 KAP family P-loop domain AAA_19 PF13245.6 EEA21036.1 - 0.00046 20.5 0.1 0.00093 19.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EEA21036.1 - 0.002 17.4 0.1 0.0034 16.6 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.6 EEA21036.1 - 0.005 16.6 1.0 0.0093 15.7 0.1 1.9 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EEA21036.1 - 0.0053 16.1 0.1 0.0091 15.4 0.1 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_29 PF13555.6 EEA21036.1 - 0.0067 16.2 0.6 0.018 14.8 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_14 PF13173.6 EEA21036.1 - 0.017 15.2 0.1 0.094 12.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EEA21036.1 - 0.022 15.3 0.0 0.052 14.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter PIF1 PF05970.14 EEA21036.1 - 0.025 13.8 0.1 0.056 12.6 0.1 1.6 1 0 0 1 1 1 0 PIF1-like helicase AAA_25 PF13481.6 EEA21036.1 - 0.039 13.5 0.3 0.091 12.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF2791 PF10923.8 EEA21036.1 - 0.053 12.4 0.0 0.084 11.7 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Gtr1_RagA PF04670.12 EEA21036.1 - 0.063 12.6 0.4 0.11 11.8 0.4 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EEA21036.1 - 0.064 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_7 PF12775.7 EEA21036.1 - 0.081 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region BAG6 PF12057.8 EEA21036.1 - 0.12 12.1 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 BCL2-associated athanogene 6 TsaE PF02367.17 EEA21036.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RGS PF00615.19 EEA21037.1 - 1.5e-33 115.5 0.0 3.8e-33 114.3 0.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 EEA21037.1 - 1e-25 89.6 0.0 7.3e-19 67.6 0.0 3.4 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Replic_Relax PF13814.6 EEA21037.1 - 0.0035 17.4 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 2 Replication-relaxation CDC73_C PF05179.14 EEA21038.1 - 3.4e-53 179.5 0.0 5.9e-53 178.8 0.0 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal DUF3819 PF12842.7 EEA21039.1 - 0.0034 17.3 2.6 0.07 13.1 2.6 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3819) DUF5314 PF17241.2 EEA21039.1 - 0.014 15.1 3.0 0.26 10.9 0.7 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5314) Abhydrolase_4 PF08386.10 EEA21039.1 - 0.031 14.4 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Phage_T7_Capsid PF05396.11 EEA21039.1 - 0.033 14.5 0.6 0.055 13.8 0.6 1.4 1 0 0 1 1 1 0 Phage T7 capsid assembly protein Spo0A_C PF08769.11 EEA21039.1 - 0.039 14.0 0.9 0.085 12.9 0.9 1.6 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal SSPI PF14098.6 EEA21039.1 - 0.044 14.0 4.1 0.27 11.4 1.1 2.5 1 1 1 2 2 2 0 Small, acid-soluble spore protein I EcsC PF12787.7 EEA21039.1 - 0.079 12.6 1.2 0.15 11.7 0.7 1.6 1 1 1 2 2 2 0 EcsC protein family TonB_2 PF13103.6 EEA21039.1 - 0.091 13.0 2.5 4.8 7.5 0.7 3.1 1 1 1 2 2 2 0 TonB C terminal Dak2 PF02734.17 EEA21039.1 - 0.12 12.3 1.1 0.18 11.7 1.1 1.2 1 0 0 1 1 1 0 DAK2 domain DNTTIP1_dimer PF18192.1 EEA21039.1 - 0.14 12.6 4.7 1.9 8.9 2.9 2.6 1 1 2 3 3 3 0 DNTTIP1 dimerisation domain YpjP PF14005.6 EEA21039.1 - 0.16 12.0 4.2 0.34 10.9 4.2 1.9 1 1 0 1 1 1 0 YpjP-like protein SecD_SecF PF02355.16 EEA21039.1 - 0.16 11.3 0.7 0.56 9.6 0.5 1.7 1 1 1 2 2 2 0 Protein export membrane protein DUF445 PF04286.12 EEA21039.1 - 0.19 11.5 3.1 0.22 11.3 3.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF445) ARGLU PF15346.6 EEA21039.1 - 0.35 10.8 5.1 0.21 11.5 3.1 1.6 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 Trns_repr_metal PF02583.17 EEA21039.1 - 0.41 11.0 3.1 3.9 7.9 3.1 2.2 1 1 0 1 1 1 0 Metal-sensitive transcriptional repressor DUF4355 PF14265.6 EEA21039.1 - 0.47 10.7 8.2 7.8 6.8 0.3 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4355) Sec3_C_2 PF15278.6 EEA21039.1 - 0.77 10.1 4.1 4.6 7.6 0.5 2.8 2 1 1 3 3 3 0 Sec3 exocyst complex subunit RNase_J_C PF17770.1 EEA21039.1 - 1.6 9.9 4.9 1.3 10.1 2.3 2.2 2 1 0 2 2 2 0 Ribonuclease J C-terminal domain Ribosomal_S5 PF00333.20 EEA21039.1 - 2.4 8.2 5.0 19 5.4 0.4 2.7 2 1 0 2 2 2 0 Ribosomal protein S5, N-terminal domain SET PF00856.28 EEA21040.1 - 1.4e-06 28.8 1.4 7.8e-06 26.4 0.3 2.6 2 1 0 2 2 2 1 SET domain PHD PF00628.29 EEA21040.1 - 1e-05 25.3 11.8 2e-05 24.4 11.8 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EEA21040.1 - 2.8 7.6 5.8 5 6.8 5.8 1.4 1 0 0 1 1 1 0 PHD-finger WD40 PF00400.32 EEA21041.1 - 5.9e-14 52.2 16.7 0.0003 21.5 1.9 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA21041.1 - 2e-06 28.0 0.2 0.091 13.1 0.0 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA21041.1 - 0.033 13.1 0.2 2.5 7.0 0.0 2.6 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Rav1p_C PF12234.8 EEA21041.1 - 0.046 12.1 0.0 0.067 11.6 0.0 1.2 1 0 0 1 1 1 0 RAVE protein 1 C terminal Glycos_transf_4 PF00953.21 EEA21042.1 - 1.5e-32 112.8 11.8 1.5e-32 112.8 11.8 2.5 3 1 0 3 3 3 1 Glycosyl transferase family 4 P5CR_dimer PF14748.6 EEA21043.1 - 6.7e-19 68.1 4.2 9.4e-19 67.6 2.8 1.9 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EEA21043.1 - 4.8e-08 33.5 0.2 0.00014 22.3 0.0 2.9 3 0 0 3 3 3 2 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EEA21043.1 - 0.04 13.3 0.7 1.3 8.4 0.3 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Dynamin_M PF01031.20 EEA21045.1 - 0.00057 19.2 0.0 0.00083 18.7 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EEA21046.1 - 2.8e-32 112.1 0.0 3.5e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EEA21046.1 - 0.0001 22.4 0.1 0.0004 20.5 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EEA21046.1 - 0.017 14.9 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EEA21046.1 - 0.056 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 EEA21046.1 - 0.077 12.5 0.1 5.7 6.5 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B FtsK_SpoIIIE PF01580.18 EEA21046.1 - 0.13 11.6 0.1 0.46 9.8 0.0 1.9 1 1 1 2 2 2 0 FtsK/SpoIIIE family AAA_28 PF13521.6 EEA21046.1 - 0.18 12.1 0.6 0.38 11.0 0.2 1.7 2 0 0 2 2 2 0 AAA domain Amidohydro_2 PF04909.14 EEA21047.1 - 1.8e-07 31.3 0.0 2.8e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 EEA21047.1 - 3e-05 23.5 0.3 0.00043 19.7 0.3 2.5 1 1 0 1 1 1 1 Amidohydrolase family Aconitase PF00330.20 EEA21048.1 - 4.2e-163 543.6 0.0 5.1e-163 543.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EEA21048.1 - 1.8e-41 141.5 0.0 4.8e-41 140.2 0.0 1.8 1 0 0 1 1 1 1 Aconitase C-terminal domain Alpha-amylase PF00128.24 EEA21049.1 - 3.4e-17 63.0 1.8 2.1e-16 60.4 1.1 2.5 2 1 0 2 2 2 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 EEA21049.1 - 2.1e-15 57.1 0.1 4.3e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EEA21049.1 - 3.7e-05 23.3 0.0 8e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EEA21049.1 - 0.016 15.2 0.0 0.046 13.7 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DUF373 PF04123.13 EEA21049.1 - 0.23 10.9 5.8 0.53 9.7 5.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Pribosyltran PF00156.27 EEA21050.1 - 2.6e-12 46.6 0.3 4.4e-12 45.8 0.3 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MTHFR PF02219.17 EEA21051.1 - 1.6e-115 385.3 0.0 2.2e-115 384.9 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF2418 PF10332.9 EEA21053.1 - 2.7e-37 127.2 4.3 5.5e-37 126.2 0.6 2.8 4 0 0 4 4 4 1 Protein of unknown function (DUF2418) FIN1 PF17300.2 EEA21053.1 - 0.013 15.0 0.9 0.025 14.1 0.9 1.5 1 0 0 1 1 1 0 Filaments in between nuclei protein-1 ATP-synt_F PF01990.17 EEA21054.1 - 2.7e-32 111.0 0.0 3.1e-32 110.8 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit E1_DerP2_DerF2 PF02221.15 EEA21055.1 - 8.1e-25 87.8 0.1 1e-24 87.5 0.1 1.1 1 0 0 1 1 1 1 ML domain Alph_Pro_TM PF09608.10 EEA21055.1 - 0.19 11.5 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) Methyltransf_23 PF13489.6 EEA21056.1 - 4.1e-13 49.5 0.0 7e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA21056.1 - 5.4e-11 43.1 0.0 2.2e-10 41.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA21056.1 - 5e-10 39.9 0.0 1.2e-09 38.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA21056.1 - 7.6e-06 25.8 0.0 0.00013 21.7 0.0 2.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA21056.1 - 9.2e-06 26.3 0.0 2.2e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EEA21056.1 - 0.0026 17.9 0.0 0.006 16.7 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EEA21056.1 - 0.0028 17.1 0.0 0.0055 16.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 EEA21056.1 - 0.03 13.6 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain MTS PF05175.14 EEA21056.1 - 0.16 11.5 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain KH_8 PF17903.1 EEA21057.1 - 4.5e-31 106.8 0.0 9.5e-31 105.7 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EEA21057.1 - 0.031 14.1 0.0 0.09 12.6 0.0 1.9 1 0 0 1 1 1 0 KH domain KH_8 PF17903.1 EEA21058.1 - 2.4e-29 101.3 0.0 5.2e-29 100.2 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EEA21058.1 - 0.024 14.4 0.0 0.074 12.9 0.0 1.9 1 0 0 1 1 1 0 KH domain Vfa1 PF08432.10 EEA21058.1 - 7 6.9 22.2 11 6.3 22.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4573 PF15140.6 EEA21059.1 - 2e-07 31.0 0.0 1.8 8.3 0.0 3.9 1 1 3 4 4 4 4 Domain of unknown function (DUF4573) ADH_zinc_N PF00107.26 EEA21060.1 - 1.1e-20 74.0 0.0 1.9e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA21060.1 - 1.6e-15 56.9 0.1 2.7e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EEA21060.1 - 8.3e-10 39.8 0.0 1.4e-09 39.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA21060.1 - 0.00031 20.2 0.1 0.00061 19.2 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EEA21060.1 - 0.00052 19.4 0.7 0.0013 18.1 0.0 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 EEA21060.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ATP_synt_H PF05493.13 EEA21062.1 - 6.5e-23 81.0 3.4 7.2e-23 80.8 3.4 1.0 1 0 0 1 1 1 1 ATP synthase subunit H Pox_A14 PF05767.12 EEA21062.1 - 0.052 13.7 0.5 0.056 13.6 0.5 1.1 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF4131 PF13567.6 EEA21062.1 - 0.062 12.9 2.2 0.065 12.9 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF1129 PF06570.11 EEA21062.1 - 0.19 11.2 0.4 0.22 11.0 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Caveolin PF01146.17 EEA21062.1 - 0.37 10.7 4.2 0.69 9.9 4.2 1.5 1 1 0 1 1 1 0 Caveolin HCV_NS4a PF01006.20 EEA21062.1 - 5.5 6.8 5.5 0.51 10.1 0.8 1.7 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a ATP_synt_H PF05493.13 EEA21063.1 - 6.5e-23 81.0 3.4 7.2e-23 80.8 3.4 1.0 1 0 0 1 1 1 1 ATP synthase subunit H Pox_A14 PF05767.12 EEA21063.1 - 0.052 13.7 0.5 0.056 13.6 0.5 1.1 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF4131 PF13567.6 EEA21063.1 - 0.062 12.9 2.2 0.065 12.9 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF1129 PF06570.11 EEA21063.1 - 0.19 11.2 0.4 0.22 11.0 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Caveolin PF01146.17 EEA21063.1 - 0.37 10.7 4.2 0.69 9.9 4.2 1.5 1 1 0 1 1 1 0 Caveolin HCV_NS4a PF01006.20 EEA21063.1 - 5.5 6.8 5.5 0.51 10.1 0.8 1.7 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a BAR_2 PF10455.9 EEA21064.1 - 2.9e-63 213.7 0.5 4.1e-63 213.2 0.5 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EEA21064.1 - 3e-23 82.7 4.5 6.8e-22 78.3 4.5 2.0 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EEA21064.1 - 0.00033 20.4 0.7 0.036 13.8 0.0 2.2 2 0 0 2 2 2 2 BAR domain of APPL family BAR_2 PF10455.9 EEA21065.1 - 3.1e-63 213.6 0.5 4.4e-63 213.1 0.5 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EEA21065.1 - 3.2e-23 82.6 4.5 7.4e-22 78.2 4.5 2.0 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EEA21065.1 - 0.00023 20.9 0.6 0.028 14.1 0.0 2.2 2 0 0 2 2 2 2 BAR domain of APPL family ADH_zinc_N PF00107.26 EEA21067.1 - 8.1e-25 87.3 0.1 1.4e-24 86.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA21067.1 - 5.4e-17 61.6 0.8 9.6e-17 60.8 0.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EEA21067.1 - 1.5e-06 29.3 0.0 2.6e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TNFR_c6 PF00020.18 EEA21067.1 - 1.1 9.8 5.7 0.11 12.9 1.3 1.6 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region SR1P PF13790.6 EEA21067.1 - 5.6 7.2 7.1 7.2 6.8 0.3 2.5 2 0 0 2 2 2 0 SR1 protein ADH_zinc_N PF00107.26 EEA21068.1 - 7.9e-25 87.3 0.1 1.3e-24 86.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA21068.1 - 2.8e-19 69.0 0.7 4.9e-19 68.2 0.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EEA21068.1 - 1.5e-06 29.3 0.0 2.5e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TNFR_c6 PF00020.18 EEA21068.1 - 0.052 14.0 1.3 0.11 12.9 1.3 1.5 1 0 0 1 1 1 0 TNFR/NGFR cysteine-rich region SR1P PF13790.6 EEA21068.1 - 5.5 7.2 7.1 7.1 6.8 0.3 2.5 2 0 0 2 2 2 0 SR1 protein Arv1 PF04161.13 EEA21069.1 - 3.3e-61 207.1 0.0 1.7e-52 178.6 0.0 2.3 2 0 0 2 2 2 2 Arv1-like family Fungal_trans_2 PF11951.8 EEA21070.1 - 3e-14 52.6 8.8 4.3e-13 48.8 0.2 3.4 4 0 0 4 4 4 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21070.1 - 3.2e-07 30.3 12.2 5.8e-07 29.5 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EEA21070.1 - 7.7 6.4 23.1 14 5.6 23.1 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_8 PF05148.15 EEA21071.1 - 2.8e-54 184.3 0.1 5.8e-51 173.4 0.0 2.9 3 0 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EEA21071.1 - 1.5e-06 28.7 0.0 4.3e-06 27.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA21071.1 - 3.6e-05 24.4 0.0 0.0014 19.3 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain DNA_pol_B_thumb PF14791.6 EEA21071.1 - 0.43 10.8 2.0 1 9.6 0.0 2.7 3 0 0 3 3 3 0 DNA polymerase beta thumb Zip PF02535.22 EEA21071.1 - 0.79 8.9 8.7 4 6.6 0.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Methyltransf_32 PF13679.6 EEA21071.1 - 0.94 9.5 0.0 0.94 9.5 0.0 3.3 3 1 0 3 3 2 0 Methyltransferase domain DUF4471 PF14740.6 EEA21071.1 - 1.3 8.1 10.8 0.32 10.2 3.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DDHD PF02862.17 EEA21071.1 - 3.8 7.6 9.9 19 5.3 6.5 2.4 2 0 0 2 2 2 0 DDHD domain FmiP_Thoc5 PF09766.9 EEA21071.1 - 5.8 6.1 18.8 0.038 13.3 6.7 2.3 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 CPSF100_C PF13299.6 EEA21071.1 - 6.8 6.8 20.7 6.2 7.0 12.7 2.7 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4746 PF15928.5 EEA21071.1 - 9.1 5.6 15.6 2.9 7.3 8.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Proteasome PF00227.26 EEA21072.1 - 8.1e-56 188.5 0.2 1e-55 188.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA21072.1 - 1.5e-12 46.9 0.2 3.6e-12 45.7 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature GCP_N_terminal PF17681.1 EEA21073.1 - 9.8e-68 229.0 0.0 1.7e-67 228.3 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EEA21073.1 - 1.3e-62 212.0 5.3 1.3e-62 212.0 5.3 1.5 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal AMP-binding PF00501.28 EEA21074.1 - 1.4e-57 195.2 0.0 2e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA21074.1 - 0.00061 20.7 0.1 0.0024 18.8 0.1 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Thiolase_N PF00108.23 EEA21075.1 - 5.4e-64 216.1 1.6 6.1e-64 215.9 0.1 1.9 3 0 0 3 3 3 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA21075.1 - 5.3e-43 145.6 0.6 5.3e-43 145.6 0.6 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EEA21075.1 - 0.0036 17.1 0.2 0.22 11.4 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 EEA21075.1 - 0.043 14.0 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 EEA21075.1 - 0.057 13.0 2.0 0.13 11.8 1.0 2.1 3 0 0 3 3 3 0 Beta-ketoacyl synthase, N-terminal domain SasG_E PF17041.5 EEA21075.1 - 0.15 12.1 0.6 0.42 10.7 0.6 1.8 1 0 0 1 1 1 0 E domain DUF1996 PF09362.10 EEA21076.1 - 1.1e-86 290.6 0.3 1.6e-86 290.1 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.19 EEA21076.1 - 1e-20 73.7 8.9 3.8e-20 71.9 8.9 2.1 1 0 0 1 1 1 1 WSC domain GST_N PF02798.20 EEA21077.1 - 3.9e-08 33.5 0.0 4.1e-07 30.3 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA21077.1 - 8e-08 32.4 0.0 1.5e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA21077.1 - 1.4e-06 28.5 0.0 2.2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA21077.1 - 2.2e-06 27.6 0.1 5e-06 26.4 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA21077.1 - 1.7e-05 25.1 0.2 0.0003 21.1 0.1 2.5 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA21077.1 - 0.0026 18.0 0.3 0.032 14.5 0.0 2.8 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Bac_rhamnosid6H PF17389.2 EEA21078.1 - 5.1e-129 430.4 0.1 6.7e-129 430.0 0.1 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EEA21078.1 - 7e-55 185.5 0.0 1.5e-54 184.4 0.0 1.6 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EEA21078.1 - 6.7e-26 90.2 0.0 1.2e-25 89.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain DUF3344 PF11824.8 EEA21078.1 - 0.0054 16.4 0.0 0.77 9.3 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3344) Sugar_tr PF00083.24 EEA21079.1 - 6.6e-88 295.5 29.1 7.5e-88 295.4 29.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA21079.1 - 2.7e-30 105.5 33.1 2.7e-30 105.5 33.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA21079.1 - 0.00035 19.1 2.0 0.00035 19.1 2.0 2.5 3 0 0 3 3 3 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.18 EEA21080.1 - 2.7e-10 39.7 0.8 4.7e-10 38.9 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21080.1 - 0.0014 18.7 7.0 0.0031 17.6 7.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ComX PF05952.12 EEA21080.1 - 0.031 14.2 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 Bacillus competence pheromone ComX F-box-like PF12937.7 EEA21081.1 - 5.2e-08 32.7 1.1 1e-07 31.7 1.1 1.5 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EEA21081.1 - 0.00031 20.6 0.5 0.00073 19.4 0.1 1.7 2 0 0 2 2 2 1 F-box F-box PF00646.33 EEA21081.1 - 0.0041 17.0 0.3 0.0041 17.0 0.3 1.8 2 0 0 2 2 2 1 F-box domain NAT PF04768.13 EEA21082.1 - 8e-49 165.6 0.0 1.8e-48 164.4 0.0 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase NAD_binding_2 PF03446.15 EEA21083.1 - 1.3e-29 103.5 0.0 2e-29 102.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA21083.1 - 3.4e-09 37.0 0.0 1.4e-08 35.0 0.0 2.1 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EEA21083.1 - 2.5e-08 34.1 0.0 4.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EEA21083.1 - 9.5e-08 32.5 0.0 1.8e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 EEA21083.1 - 0.0018 17.3 0.0 0.06 12.3 0.0 2.2 2 0 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family CIA30 PF08547.12 EEA21084.1 - 1.1e-30 106.8 0.0 1.4e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) ATG22 PF11700.8 EEA21086.1 - 1.6e-134 449.2 27.0 1.9e-134 448.9 27.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Gelsolin PF00626.22 EEA21087.1 - 1.7e-31 107.9 0.9 2.5e-11 43.3 0.0 3.4 3 1 0 3 3 3 3 Gelsolin repeat p450 PF00067.22 EEA21088.1 - 2.5e-63 214.4 0.0 3.3e-63 214.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 EEA21089.1 - 3e-16 59.4 0.0 4.9e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GalP_UDP_transf PF01087.22 EEA21090.1 - 3.6e-71 239.4 0.5 8.4e-70 234.9 0.1 2.5 3 0 0 3 3 3 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 EEA21090.1 - 3.3e-60 202.6 0.1 1.1e-59 200.9 0.1 1.7 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 EEA21090.1 - 0.0048 15.8 0.0 0.37 9.6 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4921) HIT PF01230.23 EEA21090.1 - 0.028 15.2 0.0 0.12 13.1 0.0 2.1 2 1 0 2 2 2 0 HIT domain DcpS_C PF11969.8 EEA21090.1 - 0.17 12.4 0.0 0.45 11.0 0.0 1.7 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding Erg28 PF03694.13 EEA21091.1 - 2e-40 137.6 3.0 2.4e-40 137.3 3.0 1.0 1 0 0 1 1 1 1 Erg28 like protein adh_short PF00106.25 EEA21092.1 - 2.1e-38 131.8 0.0 3.5e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21092.1 - 5.2e-22 78.6 0.0 7.1e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA21092.1 - 2.6e-05 24.2 0.0 7.2e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EEA21092.1 - 0.00063 19.0 0.0 0.00085 18.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein T3SS_needle_reg PF09025.10 EEA21092.1 - 0.039 13.9 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 YopR, type III needle-polymerisation regulator F420_oxidored PF03807.17 EEA21092.1 - 0.17 12.5 0.0 0.31 11.7 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Aldedh PF00171.22 EEA21093.1 - 4e-148 493.8 0.0 4.5e-148 493.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 EEA21094.1 - 4e-148 493.8 0.0 4.5e-148 493.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fungal_trans PF04082.18 EEA21095.1 - 9e-07 28.2 0.0 1.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3143 PF11341.8 EEA21095.1 - 0.00048 20.4 0.1 0.44 10.9 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF3143) adh_short_C2 PF13561.6 EEA21096.1 - 1.3e-58 198.3 0.0 1.6e-58 198.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA21096.1 - 1.2e-45 155.4 0.2 1.6e-45 155.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA21096.1 - 1.1e-07 32.0 0.0 1.9e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.18 EEA21096.1 - 0.0002 21.6 0.1 0.00033 20.9 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 EEA21096.1 - 0.00024 20.7 0.1 0.0006 19.3 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA21096.1 - 0.013 14.7 0.4 0.023 13.9 0.4 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 EEA21096.1 - 0.026 14.4 0.1 0.038 13.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EEA21096.1 - 0.11 12.5 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Iso_dh PF00180.20 EEA21097.1 - 1.5e-25 90.1 0.0 1.7e-25 89.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Ank_5 PF13857.6 EEA21098.1 - 6.2e-05 23.2 0.0 0.00024 21.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EEA21098.1 - 0.037 14.5 0.1 2 9.0 0.1 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 EEA21098.1 - 0.062 13.9 0.0 0.15 12.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Sugar_tr PF00083.24 EEA21099.1 - 5.6e-135 450.7 30.8 6.4e-135 450.5 30.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA21099.1 - 3.2e-25 88.8 50.5 2.7e-20 72.6 31.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2530 PF10745.9 EEA21099.1 - 0.025 14.8 2.2 0.025 14.8 2.2 4.5 6 0 0 6 6 6 0 Protein of unknown function (DUF2530) NOG1_N PF17835.1 EEA21102.1 - 1.7e-48 164.6 0.1 1.7e-48 164.6 0.1 2.5 3 0 0 3 3 3 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EEA21102.1 - 3.6e-30 103.7 4.2 7.7e-30 102.7 4.2 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EEA21102.1 - 3.2e-26 90.9 0.4 6.9e-26 89.8 0.4 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EEA21102.1 - 4.8e-16 58.9 0.0 1.1e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA21102.1 - 1.9e-07 30.8 0.1 5.9e-07 29.1 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA21102.1 - 0.0028 17.7 0.0 2 8.4 0.0 2.8 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.6 EEA21102.1 - 0.0064 16.9 0.3 0.2 12.1 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA21102.1 - 0.008 16.1 1.1 3.1 7.7 0.1 3.4 3 1 0 3 3 3 1 RsgA GTPase AAA_23 PF13476.6 EEA21102.1 - 0.59 10.6 4.3 1.4 9.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain Acetyltransf_10 PF13673.7 EEA21103.1 - 6.9e-12 45.4 0.0 1e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA21103.1 - 4.2e-11 43.1 0.0 1e-10 41.8 0.0 1.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA21103.1 - 2.2e-07 31.2 0.0 4.1e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA21103.1 - 0.0039 17.1 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EEA21103.1 - 0.0086 16.2 0.0 0.022 14.8 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA21103.1 - 0.031 14.4 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Asp_protease PF09668.10 EEA21104.1 - 1.6e-61 205.5 0.1 2.6e-61 204.9 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EEA21104.1 - 1.2e-22 80.2 0.0 2.9e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EEA21104.1 - 7.1e-12 45.8 0.1 8e-11 42.4 0.0 2.6 2 1 1 3 3 3 1 Aspartyl protease ubiquitin PF00240.23 EEA21104.1 - 4.4e-11 42.4 0.0 9.2e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EEA21104.1 - 6e-08 32.4 0.1 1.7e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.8 EEA21104.1 - 0.00013 21.7 1.7 0.00064 19.5 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like RVP PF00077.20 EEA21104.1 - 0.00014 22.1 0.4 0.0017 18.6 0.0 2.8 2 1 2 4 4 4 1 Retroviral aspartyl protease RVP_2 PF08284.11 EEA21104.1 - 0.0022 17.7 0.0 0.0053 16.5 0.0 1.5 1 1 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.6 EEA21104.1 - 0.0065 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.16 EEA21104.1 - 0.012 15.3 0.1 0.65 9.8 0.0 2.6 2 0 0 2 2 2 0 CUE domain acVLRF1 PF18859.1 EEA21104.1 - 0.021 15.1 2.0 0.047 14.0 2.0 1.6 1 0 0 1 1 1 0 Actinobacteria/chloroflexi VLRF1 release factor DUF3947 PF13135.6 EEA21104.1 - 1.8 8.8 11.6 0.17 12.1 5.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3947) Snurportin1 PF11538.8 EEA21104.1 - 6 7.1 10.2 1.8 8.8 1.5 2.4 2 0 0 2 2 2 0 Snurportin1 DUF2781 PF10914.8 EEA21105.1 - 2.1e-36 125.5 10.2 2.4e-36 125.3 10.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) PPR_2 PF13041.6 EEA21106.1 - 0.098 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 PPR repeat family Smg4_UPF3 PF03467.15 EEA21107.1 - 0.069 13.2 0.0 0.09 12.8 0.0 1.1 1 0 0 1 1 1 0 Smg-4/UPF3 family UbiA PF01040.18 EEA21108.1 - 1e-35 123.2 14.0 1.4e-35 122.8 14.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF1616 PF07760.11 EEA21108.1 - 0.21 10.9 3.6 1 8.7 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) Nucleoporin_N PF08801.11 EEA21109.1 - 1.9e-92 310.3 1.9 3.3e-92 309.5 1.9 1.4 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EEA21109.1 - 5e-51 174.2 4.6 8.1e-50 170.2 1.5 2.1 2 0 0 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal YqeY PF09424.10 EEA21110.1 - 1.5e-23 83.5 3.0 1.7e-23 83.3 3.0 1.0 1 0 0 1 1 1 1 Yqey-like protein 5-FTHF_cyc-lig PF01812.20 EEA21111.1 - 1.3e-36 126.2 0.0 2.2e-36 125.5 0.0 1.3 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family 5-FTHF_cyc-lig PF01812.20 EEA21112.1 - 1.5e-28 99.9 0.0 2.6e-28 99.1 0.0 1.3 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family 5-FTHF_cyc-lig PF01812.20 EEA21113.1 - 1.8e-28 99.7 0.0 3e-28 98.9 0.0 1.3 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Rot1 PF10681.9 EEA21114.1 - 3.4e-95 317.5 0.0 3.9e-95 317.3 0.0 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal LSM PF01423.22 EEA21115.1 - 2.4e-13 49.6 0.1 2.8e-13 49.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EEA21115.1 - 0.0013 18.4 0.1 0.0019 17.8 0.1 1.3 1 0 0 1 1 1 1 Hfq protein Xpo1 PF08389.12 EEA21116.1 - 3.3e-28 98.6 0.2 3.4e-27 95.3 0.1 2.7 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 EEA21116.1 - 2.4e-06 27.4 0.0 1.1e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 EEA21116.1 - 0.056 14.0 0.8 6.8 7.3 0.0 4.5 5 0 0 5 5 5 0 HEAT-like repeat TerB PF05099.13 EEA21116.1 - 0.07 13.1 3.4 0.3 11.0 0.1 2.9 3 0 0 3 3 3 0 Tellurite resistance protein TerB GAT PF03127.14 EEA21116.1 - 0.49 10.7 4.5 1.7 9.0 0.0 3.5 4 0 0 4 4 4 0 GAT domain Fungal_trans PF04082.18 EEA21117.1 - 7.8e-61 205.4 0.0 1.2e-60 204.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA21117.1 - 8.1e-05 22.9 15.0 0.0063 16.9 4.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA21117.1 - 4 8.0 10.8 0.91 10.1 3.1 2.7 2 0 0 2 2 2 0 Zinc-finger double domain EF-hand_7 PF13499.6 EEA21118.1 - 4.5e-12 46.3 0.6 2.4e-07 31.1 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EEA21118.1 - 4e-10 39.9 0.1 0.00011 22.4 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 EEA21118.1 - 3.8e-09 35.8 1.0 0.0046 16.8 0.0 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EEA21118.1 - 6.6e-09 34.7 0.6 0.017 14.6 0.0 3.8 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EEA21118.1 - 3.4e-07 30.0 0.8 0.00032 20.5 0.1 3.2 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 EEA21119.1 - 5.1e-12 46.1 0.6 2.6e-07 31.0 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EEA21119.1 - 4.6e-10 39.7 0.1 0.00012 22.3 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 EEA21119.1 - 4.5e-09 35.5 1.0 0.0049 16.7 0.0 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EEA21119.1 - 7.9e-09 34.4 0.5 0.018 14.5 0.0 3.8 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EEA21119.1 - 4.2e-07 29.7 0.8 0.00034 20.4 0.1 3.2 2 1 1 3 3 3 1 EF-hand domain pair Peptidase_M3 PF01432.20 EEA21121.1 - 1.3e-158 529.1 0.0 1.7e-158 528.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 FA_desaturase PF00487.24 EEA21122.1 - 2.7e-19 70.0 15.2 4.4e-19 69.3 15.2 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EEA21122.1 - 1e-16 60.8 0.1 2.5e-16 59.6 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF1189 PF06691.11 EEA21122.1 - 0.1 12.1 0.5 0.27 10.8 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) Pkinase PF00069.25 EEA21123.1 - 1.2e-21 77.3 0.0 7.6e-21 74.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA21123.1 - 1e-15 57.8 0.0 9.7e-11 41.4 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase BAR PF03114.18 EEA21123.1 - 0.44 10.1 2.0 0.61 9.7 0.9 1.7 2 0 0 2 2 2 0 BAR domain CorA PF01544.18 EEA21124.1 - 9.1e-15 54.7 4.1 9.1e-15 54.7 4.1 1.5 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein SCAI PF12070.8 EEA21125.1 - 0.19 10.6 1.4 0.25 10.2 1.4 1.1 1 0 0 1 1 1 0 Protein SCAI AA_permease PF00324.21 EEA21126.1 - 3e-38 131.6 43.3 9.4e-24 83.8 25.7 2.8 2 1 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EEA21126.1 - 9.9e-20 70.8 41.3 5.6e-19 68.3 41.3 2.1 1 1 1 2 2 2 1 Amino acid permease PAP2 PF01569.21 EEA21127.1 - 4e-27 94.7 0.3 1.3e-26 92.9 0.3 1.9 1 1 0 1 1 1 1 PAP2 superfamily DUF805 PF05656.14 EEA21127.1 - 0.0035 17.7 0.6 2.1 8.8 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF805) Sulf_transp PF04143.14 EEA21127.1 - 0.012 15.2 0.4 0.012 15.2 0.4 1.8 3 0 0 3 3 3 0 Sulphur transport DDE_Tnp_1_7 PF13843.6 EEA21128.1 - 8.6e-58 196.3 0.4 1.6e-57 195.4 0.4 1.4 1 1 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA21128.1 - 8.6e-12 45.6 9.4 1.8e-11 44.6 9.4 1.6 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon Xan_ur_permease PF00860.20 EEA21129.1 - 3.2e-69 233.5 31.6 1.4e-68 231.4 31.6 1.8 1 1 0 1 1 1 1 Permease family Sdh_cyt PF01127.22 EEA21130.1 - 3e-22 78.9 1.2 4.2e-22 78.4 1.2 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Sdh_cyt PF01127.22 EEA21131.1 - 3e-22 78.9 1.2 4.2e-22 78.4 1.2 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Rad51 PF08423.11 EEA21132.1 - 3.2e-13 49.5 0.0 4e-10 39.4 0.0 2.4 2 0 0 2 2 2 2 Rad51 RecA PF00154.21 EEA21132.1 - 4.9e-07 29.5 0.1 8.2e-06 25.5 0.0 2.2 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 EEA21132.1 - 2.7e-06 26.9 0.1 5.2e-06 26.0 0.1 1.5 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 EEA21132.1 - 2.2e-05 24.1 0.3 0.00021 20.9 0.0 2.5 3 0 0 3 3 3 1 AAA domain DnaB_C PF03796.15 EEA21132.1 - 0.0024 17.3 0.0 0.014 14.7 0.0 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain NB-ARC PF00931.22 EEA21132.1 - 0.014 14.5 0.0 0.031 13.5 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 EEA21132.1 - 0.022 14.5 0.0 0.051 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA21132.1 - 0.04 14.3 0.1 0.14 12.5 0.0 1.9 2 0 0 2 2 2 0 RNA helicase PhoH PF02562.16 EEA21132.1 - 0.045 13.2 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA PF00004.29 EEA21132.1 - 0.051 14.0 0.6 0.15 12.5 0.1 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EEA21132.1 - 0.073 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EEA21132.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain SAP30_Sin3_bdg PF13867.6 EEA21133.1 - 6.5e-08 32.8 0.6 1.9e-07 31.3 0.1 1.9 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Alb1 PF09135.11 EEA21133.1 - 2.1 9.3 5.1 0.29 12.1 0.9 1.6 2 0 0 2 2 2 0 Alb1 zf-H2C2_2 PF13465.6 EEA21134.1 - 1.1e-07 32.0 20.4 5.8e-05 23.3 3.3 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EEA21134.1 - 1.9e-05 24.8 14.0 0.00078 19.8 4.5 3.4 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA21134.1 - 0.037 14.9 20.3 0.054 14.3 3.0 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA21134.1 - 0.048 14.0 0.2 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EEA21134.1 - 0.055 14.1 1.4 0.16 12.6 0.2 2.3 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EEA21134.1 - 0.14 12.2 0.8 9.2 6.4 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger BRO1 PF03097.18 EEA21135.1 - 1.2e-135 452.3 4.9 3.8e-135 450.6 4.9 1.9 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EEA21135.1 - 1.3e-81 274.2 15.7 1.3e-81 274.2 15.7 2.0 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV DUF3012 PF11216.8 EEA21135.1 - 0.33 11.0 1.0 18 5.5 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3012) DUF2120 PF09893.9 EEA21135.1 - 0.57 10.3 3.5 2.5 8.2 0.6 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) DUF148 PF02520.17 EEA21135.1 - 3 8.0 10.7 2.6 8.2 4.5 3.4 3 0 0 3 3 3 0 Domain of unknown function DUF148 PXA PF02194.15 EEA21135.1 - 5 7.1 5.6 92 2.9 5.6 2.7 1 1 0 1 1 1 0 PXA domain DnaJ_C PF01556.18 EEA21136.1 - 6.8e-34 117.1 0.0 1e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA21136.1 - 1.1e-21 76.7 2.2 2.2e-21 75.8 2.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EEA21136.1 - 9.9e-10 38.6 19.7 2e-09 37.6 19.7 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EEA21136.1 - 0.0027 17.6 3.1 0.0027 17.6 3.1 2.9 1 1 1 2 2 2 1 Tryptophan RNA-binding attenuator protein inhibitory protein Lon_C PF05362.13 EEA21137.1 - 7.4e-62 208.5 0.0 1.3e-61 207.8 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EEA21137.1 - 7.3e-35 120.7 0.0 1.5e-34 119.7 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EEA21137.1 - 9e-22 77.9 0.0 1.8e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA21137.1 - 9.7e-08 32.1 0.0 2.1e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 EEA21137.1 - 4.6e-06 25.8 0.3 9.6e-06 24.7 0.0 1.6 2 0 0 2 2 2 1 PrkA AAA domain AAA_2 PF07724.14 EEA21137.1 - 7.9e-06 26.1 0.0 2.5e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA21137.1 - 1.1e-05 25.8 0.1 0.00013 22.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain ChlI PF13541.6 EEA21137.1 - 1.5e-05 24.8 0.0 3.5e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EEA21137.1 - 0.00015 22.2 1.3 0.00059 20.2 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EEA21137.1 - 0.00018 21.3 0.0 0.00053 19.8 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EEA21137.1 - 0.0024 18.4 0.3 0.027 15.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 EEA21137.1 - 0.0055 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA21137.1 - 0.023 14.4 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA21137.1 - 0.026 14.3 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EEA21137.1 - 0.038 13.9 0.1 0.56 10.1 0.0 2.7 2 1 1 3 3 3 0 NTPase RNA_helicase PF00910.22 EEA21137.1 - 0.048 14.0 0.0 0.21 12.0 0.0 2.2 2 0 0 2 2 1 0 RNA helicase RsgA_GTPase PF03193.16 EEA21137.1 - 0.078 12.9 0.2 0.23 11.4 0.0 1.8 2 0 0 2 2 1 0 RsgA GTPase CHASE8 PF17152.4 EEA21137.1 - 0.079 13.2 0.2 0.31 11.3 0.1 2.0 2 0 0 2 2 2 0 Periplasmic sensor domain ABC_tran PF00005.27 EEA21137.1 - 0.11 13.0 1.2 0.43 11.1 0.1 2.5 2 1 1 3 3 2 0 ABC transporter AAA_7 PF12775.7 EEA21137.1 - 0.13 11.8 0.1 0.35 10.4 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Apt1 PF10351.9 EEA21137.1 - 0.13 11.1 5.0 0.26 10.1 5.0 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EEA21137.1 - 3.2 6.4 7.9 5.5 5.6 7.9 1.2 1 0 0 1 1 1 0 Presenilin Lon_C PF05362.13 EEA21138.1 - 7e-57 192.3 0.0 1.3e-56 191.4 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EEA21138.1 - 6.8e-35 120.8 0.0 1.4e-34 119.8 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EEA21138.1 - 8.5e-22 78.0 0.0 1.7e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA21138.1 - 1e-07 32.0 0.0 1.9e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 EEA21138.1 - 4.1e-06 26.0 0.2 9.1e-06 24.8 0.0 1.6 2 0 0 2 2 2 1 PrkA AAA domain AAA_2 PF07724.14 EEA21138.1 - 7.6e-06 26.1 0.0 2.3e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA21138.1 - 1e-05 25.9 0.1 0.00012 22.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain ChlI PF13541.6 EEA21138.1 - 1.4e-05 24.9 0.0 3.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EEA21138.1 - 0.00015 22.2 1.4 0.00057 20.3 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EEA21138.1 - 0.00017 21.4 0.0 0.00051 19.8 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EEA21138.1 - 0.0024 18.4 0.3 0.026 15.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 EEA21138.1 - 0.0055 16.7 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA21138.1 - 0.022 14.5 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA21138.1 - 0.025 14.3 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF4276 PF14103.6 EEA21138.1 - 0.03 14.6 0.2 0.069 13.4 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4276) NTPase_1 PF03266.15 EEA21138.1 - 0.034 14.1 0.1 0.53 10.2 0.0 2.7 2 1 1 3 3 3 0 NTPase RNA_helicase PF00910.22 EEA21138.1 - 0.064 13.6 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase CHASE8 PF17152.4 EEA21138.1 - 0.075 13.3 0.2 0.3 11.4 0.1 2.0 2 0 0 2 2 2 0 Periplasmic sensor domain RsgA_GTPase PF03193.16 EEA21138.1 - 0.077 12.9 0.3 0.22 11.4 0.0 1.8 2 0 0 2 2 1 0 RsgA GTPase ABC_tran PF00005.27 EEA21138.1 - 0.11 13.0 1.3 0.41 11.1 0.1 2.5 2 1 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 EEA21138.1 - 0.12 11.9 0.1 0.33 10.4 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Apt1 PF10351.9 EEA21138.1 - 0.12 11.2 5.0 0.24 10.2 5.0 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EEA21138.1 - 3.1 6.5 7.9 5.2 5.7 7.9 1.2 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 EEA21139.1 - 3.5e-10 39.7 0.0 9e-09 35.1 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA21139.1 - 3.4e-09 36.4 0.0 5.6e-08 32.4 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase NmrA PF05368.13 EEA21140.1 - 2.1e-12 47.1 0.0 3.1e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA21140.1 - 4.7e-11 42.9 0.0 6.1e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EEA21140.1 - 9.7e-05 22.6 0.0 0.00016 21.9 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Biotin_carb_N PF00289.22 EEA21140.1 - 0.082 13.5 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Biotin carboxylase, N-terminal domain Epimerase PF01370.21 EEA21140.1 - 0.18 11.2 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family CorA PF01544.18 EEA21141.1 - 2.1e-13 50.3 0.6 3.9e-13 49.4 0.6 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EEA21141.1 - 0.045 12.5 0.1 0.061 12.1 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) AMP-binding PF00501.28 EEA21142.1 - 2.4e-53 181.3 0.0 3.2e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Thioesterase PF00975.20 EEA21142.1 - 3.1e-29 102.7 0.0 1.5e-28 100.5 0.0 2.1 1 1 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 EEA21142.1 - 7.8e-12 45.4 1.3 1.8e-11 44.2 1.3 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.7 EEA21142.1 - 0.017 15.7 0.0 0.041 14.5 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family Mob1_phocein PF03637.17 EEA21143.1 - 7.5e-26 91.1 0.1 1.2e-25 90.4 0.1 1.3 1 0 0 1 1 1 1 Mob1/phocein family ALMT PF11744.8 EEA21143.1 - 0.78 8.5 5.0 1.1 8.1 5.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter cobW PF02492.19 EEA21144.1 - 1.3e-45 155.2 0.1 2.3e-45 154.3 0.1 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EEA21144.1 - 7.8e-05 22.6 0.1 0.27 11.1 0.0 2.6 3 0 0 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EEA21144.1 - 0.0003 21.2 0.1 0.0014 19.1 0.0 2.1 3 0 0 3 3 3 1 AAA ATPase domain T2SSE PF00437.20 EEA21144.1 - 0.0024 17.0 0.4 0.0045 16.1 0.4 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein CobW_C PF07683.14 EEA21144.1 - 0.0029 17.5 0.0 0.0062 16.4 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MMR_HSR1 PF01926.23 EEA21144.1 - 0.0048 17.0 0.0 0.025 14.6 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 EEA21144.1 - 0.005 15.9 0.4 2 7.3 0.0 2.9 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 EEA21144.1 - 0.0097 15.9 0.1 0.027 14.5 0.1 1.7 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EEA21144.1 - 0.022 15.3 0.0 0.047 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EEA21144.1 - 0.034 13.9 0.2 0.15 11.8 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain Septin PF00735.18 EEA21144.1 - 0.046 13.0 0.2 5.3 6.2 0.0 2.2 2 0 0 2 2 2 0 Septin ABC_tran PF00005.27 EEA21144.1 - 0.07 13.6 0.2 0.25 11.8 0.1 2.0 2 0 0 2 2 2 0 ABC transporter DUF2075 PF09848.9 EEA21144.1 - 0.091 12.0 0.1 0.17 11.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.12 EEA21144.1 - 0.098 11.9 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ATPase_2 PF01637.18 EEA21144.1 - 0.12 12.3 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EEA21144.1 - 0.16 12.3 0.1 0.47 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA21144.1 - 0.18 12.3 0.5 0.45 11.0 0.1 1.9 2 0 0 2 2 2 0 AAA domain HAUS6_N PF14661.6 EEA21145.1 - 2.2e-45 155.1 1.2 2.2e-45 155.1 1.2 1.6 1 1 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus Pox_A51 PF04948.13 EEA21145.1 - 0.054 12.3 0.0 0.097 11.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A51 protein HD_3 PF13023.6 EEA21146.1 - 4e-48 163.5 0.2 4.8e-48 163.2 0.2 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EEA21146.1 - 5.5e-14 52.3 0.1 6.8e-14 52.0 0.1 1.1 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HIT PF01230.23 EEA21147.1 - 6e-25 87.8 0.0 9.4e-25 87.2 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EEA21147.1 - 4.7e-05 23.8 0.0 6.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding GalP_UDP_tr_C PF02744.17 EEA21147.1 - 0.076 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Rad4 PF03835.15 EEA21148.1 - 2.3e-35 121.5 0.2 2.3e-35 121.5 0.2 2.0 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EEA21148.1 - 3.7e-29 100.9 0.1 8e-29 99.9 0.1 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EEA21148.1 - 2.9e-15 55.8 0.1 5.7e-15 54.9 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EEA21148.1 - 1.3e-13 51.6 0.3 1.3e-13 51.6 0.3 2.7 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EEA21148.1 - 7.8e-06 26.3 0.0 3.7e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Transglutaminase-like superfamily DUF3420 PF11900.8 EEA21148.1 - 0.12 12.5 0.6 0.37 11.0 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) CoA_binding_2 PF13380.6 EEA21149.1 - 2.1e-28 99.1 0.0 2.7e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain RrnaAD PF00398.20 EEA21152.1 - 3.1e-57 193.7 0.0 4.1e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EEA21152.1 - 0.00057 20.5 0.0 0.0014 19.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA21152.1 - 0.00073 20.1 0.0 0.0016 19.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FA_hydroxylase PF04116.13 EEA21154.1 - 6.6e-22 78.3 10.8 6.6e-22 78.3 10.8 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily MFS_1 PF07690.16 EEA21155.1 - 7.8e-22 77.7 34.0 3.4e-14 52.5 17.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA21155.1 - 9.8e-18 64.2 15.5 3.5e-17 62.4 15.5 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter HRI1 PF16815.5 EEA21156.1 - 4.4e-25 88.7 0.2 6.4e-25 88.2 0.2 1.2 1 1 0 1 1 1 1 Protein HRI1 AAA PF00004.29 EEA21158.1 - 5.6e-16 59.2 0.0 1.1e-15 58.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA21158.1 - 0.0008 19.8 0.7 0.01 16.2 0.7 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA21158.1 - 0.02 15.1 0.0 0.093 13.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Abhydrolase_8 PF06259.12 EEA21161.1 - 0.016 14.8 0.5 0.034 13.8 0.5 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Cys_Met_Meta_PP PF01053.20 EEA21163.1 - 2.6e-95 319.2 0.0 3.2e-95 318.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EEA21163.1 - 7.3e-08 32.1 2.0 2.2e-07 30.5 1.9 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EEA21163.1 - 3.7e-06 26.1 0.3 5.9e-06 25.5 0.3 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA21163.1 - 1.2e-05 24.8 0.1 2.2e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 EEA21163.1 - 0.0016 17.3 0.1 0.0024 16.8 0.1 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein NmrA PF05368.13 EEA21163.1 - 0.021 14.4 0.3 0.033 13.7 0.3 1.3 1 0 0 1 1 1 0 NmrA-like family Cys_Met_Meta_PP PF01053.20 EEA21164.1 - 2.4e-88 296.2 0.0 3.2e-88 295.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EEA21164.1 - 7.1e-08 32.1 2.0 2.2e-07 30.6 1.9 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EEA21164.1 - 3.7e-06 26.1 0.3 5.7e-06 25.5 0.3 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA21164.1 - 1.2e-05 24.8 0.1 2.1e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 EEA21164.1 - 0.0016 17.3 0.1 0.0023 16.8 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein NmrA PF05368.13 EEA21164.1 - 0.02 14.4 0.3 0.032 13.8 0.3 1.3 1 0 0 1 1 1 0 NmrA-like family DAO PF01266.24 EEA21165.1 - 7.3e-33 114.6 0.0 9.3e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fungal_trans PF04082.18 EEA21166.1 - 2.5e-21 75.9 0.0 5.1e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21166.1 - 2.9e-08 33.7 11.6 5.1e-08 32.9 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_3 PF07859.13 EEA21167.1 - 1.5e-38 132.8 0.0 1.9e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA21167.1 - 0.0027 16.7 0.3 0.005 15.8 0.3 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 EEA21167.1 - 0.13 12.9 0.0 0.19 12.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EEA21167.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Glyco_trans_2_3 PF13632.6 EEA21168.1 - 6.9e-53 179.5 2.7 6.9e-53 179.5 2.7 2.4 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EEA21168.1 - 0.0087 15.9 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_hydro_cc PF11790.8 EEA21169.1 - 1.1e-77 260.8 1.2 1.4e-77 260.5 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_16 PF00722.21 EEA21170.1 - 7.6e-17 61.3 0.5 1.5e-16 60.4 0.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Sugar_tr PF00083.24 EEA21171.1 - 8.3e-60 202.9 21.0 1.1e-59 202.6 21.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA21171.1 - 1.6e-12 47.0 23.5 1.6e-12 47.0 23.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 EEA21172.1 - 1.4e-34 119.4 0.1 8.3e-32 110.4 0.0 2.4 2 0 0 2 2 2 2 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA21172.1 - 1.3e-12 48.1 0.0 3.2e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_6 PF12697.7 EEA21172.1 - 1.7e-11 45.2 0.0 3.7e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA21172.1 - 4.2e-05 23.3 0.1 7.1e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA21172.1 - 0.0002 20.7 0.0 0.0079 15.5 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA21172.1 - 0.0015 18.4 0.1 0.21 11.4 0.0 2.8 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 EEA21172.1 - 0.0024 17.8 0.0 0.0053 16.6 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Gly_transf_sug PF04488.15 EEA21173.1 - 3.7e-16 59.5 0.0 7.6e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Ncstrn_small PF18266.1 EEA21173.1 - 0.086 12.8 0.2 0.14 12.1 0.2 1.3 1 0 0 1 1 1 0 Nicastrin small lobe Baculo_F PF12259.8 EEA21173.1 - 0.29 9.6 0.3 0.41 9.1 0.3 1.1 1 0 0 1 1 1 0 Baculovirus F protein NTP_transf_9 PF04248.12 EEA21174.1 - 1.8e-35 120.7 0.0 1.6e-26 92.0 0.0 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF427) NTP_transf_9 PF04248.12 EEA21175.1 - 5.7e-21 74.2 0.2 8e-12 44.9 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF427) UbiA PF01040.18 EEA21176.1 - 6.8e-18 64.9 14.6 2.1e-17 63.2 14.6 1.7 1 1 0 1 1 1 1 UbiA prenyltransferase family Zn_clus PF00172.18 EEA21177.1 - 1.6e-07 31.3 11.4 2.9e-07 30.5 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fasciclin PF02469.22 EEA21178.1 - 9.8e-46 155.1 3.1 1.1e-25 90.3 0.2 2.2 2 0 0 2 2 2 2 Fasciclin domain Abhydrolase_4 PF08386.10 EEA21181.1 - 5e-24 84.4 0.0 1.8e-23 82.6 0.0 1.9 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 EEA21181.1 - 2e-15 57.2 0.0 4.1e-11 43.0 0.0 2.9 2 1 0 2 2 2 2 alpha/beta hydrolase fold FAD_binding_3 PF01494.19 EEA21182.1 - 2.3e-24 86.3 0.4 1.8e-17 63.7 0.1 2.7 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EEA21182.1 - 4.3e-05 22.7 0.1 9.6e-05 21.6 0.1 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EEA21182.1 - 0.00026 20.3 0.4 0.0015 17.8 0.1 1.9 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA21182.1 - 0.00028 21.1 0.1 0.00061 20.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EEA21182.1 - 0.00079 18.8 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA21182.1 - 0.0017 17.5 0.1 0.0028 16.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EEA21182.1 - 0.013 16.0 0.1 0.065 13.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA21182.1 - 0.03 13.9 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 EEA21182.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Rop-like PF05082.13 EEA21183.1 - 0.022 14.6 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 Rop-like TM231 PF10149.9 EEA21183.1 - 0.36 10.1 3.2 0.54 9.6 3.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 231 PEP_mutase PF13714.6 EEA21184.1 - 1.6e-17 63.7 0.4 1.9e-17 63.5 0.4 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EEA21184.1 - 5.8e-07 28.4 0.1 7e-07 28.1 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family AA_permease PF00324.21 EEA21185.1 - 4.2e-105 352.1 41.4 4.8e-105 351.9 41.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA21185.1 - 3.8e-21 75.4 46.8 5.1e-21 75.0 46.8 1.2 1 0 0 1 1 1 1 Amino acid permease Glyco_hydro_11 PF00457.17 EEA21186.1 - 9.5e-44 149.1 17.7 2.8e-38 131.3 8.3 3.0 1 1 1 2 2 2 2 Glycosyl hydrolases family 11 p450 PF00067.22 EEA21187.1 - 2.4e-60 204.6 0.0 3.1e-60 204.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CpxA_peri PF16527.5 EEA21187.1 - 0.088 13.2 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain TPR_11 PF13414.6 EEA21187.1 - 0.15 11.8 0.1 0.29 10.9 0.1 1.4 1 0 0 1 1 1 0 TPR repeat Cep3 PF16846.5 EEA21188.1 - 2.1e-06 26.5 0.0 3.2e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Zn_clus PF00172.18 EEA21188.1 - 2.6e-05 24.2 7.4 4.8e-05 23.4 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA21188.1 - 0.00011 21.3 0.5 0.00021 20.4 0.5 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Transp_cyt_pur PF02133.15 EEA21189.1 - 3.3e-52 177.8 13.3 4.4e-52 177.3 13.3 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF5518 PF17647.1 EEA21189.1 - 0.016 15.4 0.1 0.016 15.4 0.1 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5518) DDE_1 PF03184.19 EEA21190.1 - 8.1e-26 90.7 0.1 2e-25 89.4 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA21190.1 - 9.1e-10 38.4 0.3 3.4e-09 36.6 0.3 2.1 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain RR_TM4-6 PF06459.12 EEA21190.1 - 3.8 7.3 14.6 6 6.6 14.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TauD PF02668.16 EEA21191.1 - 1.4e-32 113.6 0.1 1.9e-32 113.1 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Hydrolase_4 PF12146.8 EEA21192.1 - 1.5e-18 67.0 0.0 1.8e-18 66.7 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA21192.1 - 8.4e-14 52.7 0.1 1e-13 52.5 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA21192.1 - 1.1e-12 48.2 0.0 1.1e-08 35.1 0.1 2.5 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EEA21192.1 - 1.4e-05 24.9 0.0 0.00035 20.4 0.0 2.5 3 0 0 3 3 3 1 Alpha/beta hydrolase family DUF1749 PF08538.10 EEA21192.1 - 3.6e-05 23.0 0.0 9.7e-05 21.6 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) LIDHydrolase PF10230.9 EEA21192.1 - 0.0011 18.6 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 EEA21192.1 - 0.0025 17.7 0.1 0.008 16.0 0.0 1.7 1 1 0 2 2 2 1 Serine hydrolase Esterase PF00756.20 EEA21192.1 - 0.01 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 EEA21192.1 - 0.012 14.4 0.0 0.075 11.7 0.0 2.0 2 0 0 2 2 2 0 Ndr family PGAP1 PF07819.13 EEA21192.1 - 0.015 15.0 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_4 PF08386.10 EEA21192.1 - 0.019 15.0 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_2 PF02230.16 EEA21192.1 - 0.022 14.5 0.0 0.67 9.7 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 EEA21192.1 - 0.038 14.1 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 Thioesterase domain DLH PF01738.18 EEA21192.1 - 0.039 13.5 0.0 0.17 11.4 0.0 2.1 3 0 0 3 3 3 0 Dienelactone hydrolase family Lipase_3 PF01764.25 EEA21192.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) TauD PF02668.16 EEA21193.1 - 1e-26 94.4 0.0 1.8e-26 93.6 0.0 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Flavin_Reduct PF01613.18 EEA21194.1 - 1.1e-14 54.7 0.0 1.5e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain MFS_1 PF07690.16 EEA21195.1 - 6.2e-35 120.8 51.7 1.3e-33 116.4 51.7 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Transgly_assoc PF04226.13 EEA21195.1 - 0.0065 16.7 5.7 0.0065 16.7 5.7 5.0 5 0 0 5 5 5 1 Transglycosylase associated protein Pox_I5 PF04713.12 EEA21195.1 - 0.34 11.0 0.1 0.34 11.0 0.1 2.8 3 0 0 3 3 3 0 Poxvirus protein I5 Peptidase_S10 PF00450.22 EEA21196.1 - 1.3e-104 350.9 10.7 1.6e-104 350.6 10.7 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase RVT_2 PF07727.14 EEA21198.1 - 1.7e-60 204.7 0.0 2.5e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA21198.1 - 2.8e-17 63.0 0.0 1.5e-16 60.6 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EEA21198.1 - 5.1e-10 39.1 0.3 3.1e-09 36.6 0.1 2.4 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 EEA21198.1 - 0.0075 16.0 0.1 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 EEA21198.1 - 0.023 14.2 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 EEA21199.1 - 2.4e-16 59.7 0.3 3.5e-16 59.1 0.3 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EEA21199.1 - 1.7e-11 43.5 0.1 4.3e-11 42.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) zf-CCHC PF00098.23 EEA21199.1 - 2.3e-06 27.4 1.7 2.3e-06 27.4 1.7 1.8 2 0 0 2 2 2 1 Zinc knuckle CAF1A PF12253.8 EEA21199.1 - 0.012 15.7 0.3 0.04 14.1 0.3 1.8 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A zf-CCHC_6 PF15288.6 EEA21199.1 - 0.015 15.1 1.3 0.033 14.0 1.3 1.5 1 0 0 1 1 1 0 Zinc knuckle Glyco_hydro_32N PF00251.20 EEA21199.1 - 0.024 14.2 0.5 0.51 9.9 0.2 2.1 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain zf-CCHC_4 PF14392.6 EEA21199.1 - 0.053 13.3 1.6 0.67 9.7 0.3 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 EEA21199.1 - 0.086 12.7 1.2 0.18 11.7 1.2 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-C2HE PF16278.5 EEA21199.1 - 0.12 12.8 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger HscB_4_cys PF18256.1 EEA21199.1 - 0.37 10.7 2.7 0.9 9.4 2.7 1.7 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif Neuralized PF07177.12 EEA21201.1 - 0.028 14.4 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 Neuralized p450 PF00067.22 EEA21202.1 - 6e-18 64.8 0.1 8.3e-18 64.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 THDPS_N PF14790.6 EEA21204.1 - 0.023 14.5 0.0 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal LysM PF01476.20 EEA21205.1 - 1.3e-11 44.4 0.3 1.2e-05 25.3 0.0 3.4 4 0 0 4 4 4 2 LysM domain DUF1080 PF06439.11 EEA21205.1 - 4.9e-11 43.1 0.6 2.5e-06 27.7 0.0 2.6 2 0 0 2 2 2 2 Domain of Unknown Function (DUF1080) Laminin_G_2 PF02210.24 EEA21205.1 - 0.0016 19.0 0.1 1.7 9.3 0.1 2.6 2 0 0 2 2 2 2 Laminin G domain Laminin_G_3 PF13385.6 EEA21205.1 - 0.042 14.0 6.4 0.19 11.9 0.3 2.9 2 1 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily OrsD PF12013.8 EEA21207.1 - 1.4e-22 80.3 1.1 2.5e-22 79.4 0.2 1.9 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EEA21208.1 - 2.6e-19 69.7 0.0 1e-18 67.8 0.0 2.1 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA21208.1 - 8.9e-14 51.6 0.1 2.5e-13 50.2 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA21208.1 - 3.7e-12 46.6 0.0 1.5e-11 44.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA21208.1 - 1.7e-05 24.9 0.0 5.6e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EEA21208.1 - 0.0092 15.7 0.5 3.1 7.5 0.1 3.0 3 0 0 3 3 3 2 AAA domain OrsD PF12013.8 EEA21209.1 - 1e-09 38.8 1.4 1.7e-09 38.1 0.2 2.0 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_12 PF18658.1 EEA21209.1 - 0.0035 16.9 0.1 0.093 12.3 0.0 3.0 3 0 0 3 3 3 1 Zinc-finger C2H2-type zf-BED PF02892.15 EEA21209.1 - 0.047 13.7 0.9 0.047 13.7 0.9 2.5 3 0 0 3 3 3 0 BED zinc finger zf-C2H2_4 PF13894.6 EEA21209.1 - 1.6 9.7 3.9 2.3 9.3 0.7 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Ank PF00023.30 EEA21212.1 - 4.1e-28 96.6 4.1 6.1e-08 32.8 0.1 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 EEA21212.1 - 9.2e-27 93.5 0.2 1e-12 48.5 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA21212.1 - 1.2e-25 89.2 0.8 2.8e-11 43.4 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA21212.1 - 9e-22 74.8 0.8 0.00016 21.9 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EEA21212.1 - 9e-17 61.2 1.0 1.6e-07 31.7 0.0 4.1 1 1 2 4 4 4 4 Ankyrin repeats (many copies) ABC_membrane PF00664.23 EEA21213.1 - 7.4e-53 179.9 29.2 1.4e-29 103.6 13.9 3.4 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EEA21213.1 - 2e-49 167.6 0.0 4.1e-26 92.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter MMR_HSR1 PF01926.23 EEA21213.1 - 1.3e-07 31.7 0.6 0.024 14.7 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EEA21213.1 - 3.1e-07 30.5 1.6 0.26 11.1 0.0 4.2 2 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EEA21213.1 - 6.3e-07 29.7 3.8 0.00053 20.2 0.3 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_16 PF13191.6 EEA21213.1 - 1.7e-06 28.6 0.2 0.011 16.2 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EEA21213.1 - 5.9e-06 25.9 1.9 0.038 13.7 0.6 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EEA21213.1 - 6e-05 22.6 4.8 1.5 8.2 0.1 3.7 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EEA21213.1 - 0.00043 20.2 2.6 0.58 10.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EEA21213.1 - 0.00061 19.4 0.2 0.32 10.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_23 PF13476.6 EEA21213.1 - 0.00066 20.2 0.2 1.7 9.1 0.1 2.7 2 0 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.18 EEA21213.1 - 0.0012 18.2 1.1 0.49 9.7 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family DUF815 PF05673.13 EEA21213.1 - 0.0091 15.2 0.5 0.32 10.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NACHT PF05729.12 EEA21213.1 - 0.011 15.6 0.1 2.3 8.1 0.0 2.5 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 EEA21213.1 - 0.013 14.7 1.0 2.8 7.0 0.2 3.0 2 1 0 2 2 2 0 NB-ARC domain Dynamin_N PF00350.23 EEA21213.1 - 0.018 15.1 5.7 0.76 9.8 0.2 3.1 3 0 0 3 3 3 0 Dynamin family AAA_22 PF13401.6 EEA21213.1 - 0.018 15.3 3.9 3.9 7.7 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EEA21213.1 - 0.033 13.8 1.2 6.7 6.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA21213.1 - 0.041 13.6 0.1 10 5.8 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AF-4 PF05110.13 EEA21213.1 - 0.06 11.4 3.6 0.087 10.9 3.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein AAA_24 PF13479.6 EEA21213.1 - 0.069 12.9 0.2 6.6 6.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 EEA21213.1 - 0.072 13.3 0.3 17 5.7 0.1 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_10 PF12846.7 EEA21213.1 - 0.096 11.6 1.6 0.39 9.6 0.1 2.2 2 0 0 2 2 2 0 AAA-like domain Zeta_toxin PF06414.12 EEA21213.1 - 0.1 11.8 1.1 4.5 6.5 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.17 EEA21213.1 - 0.43 10.3 3.2 6.3 6.5 0.2 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 EEA21213.1 - 3.2 7.4 4.7 4 7.1 0.2 2.5 3 0 0 3 3 2 0 AAA ATPase domain p450 PF00067.22 EEA21215.1 - 1.3e-52 179.1 0.0 1.8e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Toxin_YhaV PF11663.8 EEA21215.1 - 0.077 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Toxin with endonuclease activity, of toxin-antitoxin system ADH_zinc_N PF00107.26 EEA21216.1 - 1.2e-09 38.2 0.0 2.4e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA21216.1 - 1.6e-06 27.9 1.0 3.6e-06 26.8 0.8 1.6 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EEA21216.1 - 0.0053 17.8 0.0 0.011 16.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Cpn10 PF00166.21 EEA21216.1 - 0.16 12.1 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit p450 PF00067.22 EEA21217.1 - 7e-71 239.3 0.0 9e-71 239.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FSH1 PF03959.13 EEA21218.1 - 5.5e-24 85.0 0.0 8.2e-23 81.2 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) ketoacyl-synt PF00109.26 EEA21220.1 - 2.9e-63 213.8 0.1 5.8e-63 212.8 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA21220.1 - 7.1e-49 166.2 0.0 3.5e-48 163.9 0.0 2.1 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EEA21220.1 - 3.8e-45 154.4 0.0 6.9e-45 153.6 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EEA21220.1 - 1.1e-37 130.2 0.1 2.5e-37 129.1 0.1 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA21220.1 - 2.7e-29 101.6 0.0 7.7e-29 100.1 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EEA21220.1 - 9e-19 68.1 0.0 4.5e-18 65.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EEA21220.1 - 1.6e-15 57.5 0.0 4.3e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 EEA21220.1 - 2.7e-15 56.6 0.0 5.6e-14 52.3 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA21220.1 - 1e-12 48.5 0.1 2e-11 44.4 0.0 3.4 5 0 0 5 5 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA21220.1 - 1.4e-11 44.9 0.0 5.1e-11 43.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA21220.1 - 5.4e-11 42.5 0.0 1.2e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EEA21220.1 - 1e-08 34.9 0.1 5.2e-08 32.6 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 EEA21220.1 - 6.9e-08 32.7 0.1 2e-07 31.2 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EEA21220.1 - 7.5e-06 25.7 0.0 3.1e-05 23.6 0.0 2.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 EEA21220.1 - 6e-05 22.5 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.23 EEA21220.1 - 0.0003 20.2 0.2 0.00057 19.3 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_16 PF10294.9 EEA21220.1 - 0.0012 18.7 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase NodS PF05401.11 EEA21220.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) DREV PF05219.12 EEA21220.1 - 0.19 10.8 0.0 0.55 9.3 0.0 1.7 2 0 0 2 2 2 0 DREV methyltransferase TauD PF02668.16 EEA21221.1 - 3.3e-53 181.2 0.2 3.9e-53 181.0 0.2 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family adh_short PF00106.25 EEA21222.1 - 6.9e-34 117.0 0.2 8.9e-34 116.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21222.1 - 4.5e-23 82.0 0.2 5.7e-23 81.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EEA21222.1 - 0.024 14.0 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) AA_permease PF00324.21 EEA21222.1 - 0.042 12.4 1.3 0.055 12.0 1.3 1.1 1 0 0 1 1 1 0 Amino acid permease p450 PF00067.22 EEA21223.1 - 6.6e-48 163.6 0.0 1.1e-47 162.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 ARL6IP6 PF15062.6 EEA21224.1 - 0.043 13.9 1.0 2.5 8.3 0.0 2.5 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix AKAP95 PF04988.12 EEA21224.1 - 0.064 13.5 0.0 0.091 13.0 0.0 1.2 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) NAD_synthase PF02540.17 EEA21224.1 - 0.1 11.7 0.2 0.14 11.2 0.2 1.1 1 0 0 1 1 1 0 NAD synthase DUF2070 PF09843.9 EEA21224.1 - 2.2 6.5 14.5 0.038 12.3 7.0 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Pox_A14 PF05767.12 EEA21224.1 - 3.6 7.8 9.0 0.38 10.9 2.2 2.6 1 1 1 3 3 3 0 Poxvirus virion envelope protein A14 AMP-binding PF00501.28 EEA21225.1 - 1.4e-58 198.5 0.0 2.5e-58 197.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EEA21225.1 - 3.6e-11 42.4 0.0 2.9e-10 39.4 0.0 2.2 2 1 0 2 2 2 1 Condensation domain AMP-binding_C PF13193.6 EEA21225.1 - 3.8e-09 37.4 0.1 9.6e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 EEA21225.1 - 8.7e-07 29.2 0.7 2.2e-06 27.9 0.7 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ribosomal_L16 PF00252.18 EEA21226.1 - 3.3e-20 72.5 0.7 4.3e-20 72.1 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF4597 PF15366.6 EEA21227.1 - 0.14 11.9 0.8 0.32 10.8 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) FAD_binding_3 PF01494.19 EEA21228.1 - 8.2e-07 28.6 0.0 1.7e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Cupin_2 PF07883.11 EEA21228.1 - 1.3e-05 24.9 0.0 3.3e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Cupin domain PepX_C PF08530.10 EEA21229.1 - 8.1e-45 153.5 0.0 1.4e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 EEA21229.1 - 3.1e-40 138.5 0.9 4.6e-40 137.9 0.9 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 EEA21229.1 - 0.0076 15.5 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF3122 PF11320.8 EEA21230.1 - 0.12 12.4 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) RVT_2 PF07727.14 EEA21231.1 - 1.7e-37 129.4 0.2 3e-37 128.6 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA21231.1 - 1.7e-07 31.0 0.0 4.3e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA21231.1 - 0.00047 20.3 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA21231.1 - 0.0068 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA21231.1 - 0.068 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA21231.1 - 0.1 12.9 3.2 0.27 11.5 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein REV1_C PF16727.5 EEA21232.1 - 0.081 13.3 3.5 3.6 8.1 0.3 2.5 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA21232.1 - 2.1 8.1 6.1 0.58 9.9 0.2 2.6 3 0 0 3 3 3 0 Sulfotransferase domain FAD_binding_3 PF01494.19 EEA21233.1 - 3.4e-18 66.0 4.4 6.2e-17 61.9 4.4 2.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA21233.1 - 5.5e-07 29.1 0.7 3.5e-06 26.5 0.2 2.1 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA21233.1 - 2.4e-06 27.7 0.2 8e-06 26.0 0.2 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA21233.1 - 5.1e-06 26.3 1.6 1.1e-05 25.2 0.9 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EEA21233.1 - 6.7e-06 25.2 0.8 0.039 12.8 0.3 2.5 2 1 0 2 2 2 2 Tryptophan halogenase FAD_binding_2 PF00890.24 EEA21233.1 - 0.00012 21.3 0.7 0.00021 20.5 0.7 1.3 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EEA21233.1 - 0.00061 19.2 0.7 0.62 9.3 0.1 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EEA21233.1 - 0.00073 18.9 0.6 0.0013 18.0 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA21233.1 - 0.0021 16.8 0.5 0.0045 15.7 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EEA21233.1 - 0.0079 16.7 0.1 0.017 15.7 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA21233.1 - 0.026 13.6 1.7 0.69 8.9 1.6 2.7 2 1 0 2 2 2 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EEA21233.1 - 0.031 13.6 0.4 0.066 12.5 0.4 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 EEA21233.1 - 0.056 12.7 0.2 0.1 11.8 0.2 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EEA21233.1 - 0.067 12.3 0.2 0.13 11.4 0.1 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EEA21233.1 - 0.18 11.8 0.5 2.2 8.3 0.4 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EEA21233.1 - 0.23 10.7 0.5 10 5.3 0.1 2.5 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase MFS_1 PF07690.16 EEA21234.1 - 1.3e-15 57.2 25.4 1.3e-15 57.2 25.4 2.7 1 1 2 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA21234.1 - 1.5e-08 34.0 15.0 1.5e-06 27.3 6.2 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter DUF485 PF04341.12 EEA21234.1 - 2.3 8.3 5.9 0.95 9.5 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function, DUF485 PhyH PF05721.13 EEA21235.1 - 1e-08 35.7 0.0 3.1e-08 34.1 0.0 1.7 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EEA21235.1 - 3.3e-06 26.1 0.2 0.034 12.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1479) PepX_C PF08530.10 EEA21236.1 - 1.2e-39 136.5 0.0 1.7e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 EEA21236.1 - 3.7e-39 134.9 0.4 1.4e-36 126.5 0.1 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 EEA21236.1 - 0.094 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RVT_2 PF07727.14 EEA21237.1 - 9e-11 41.9 0.0 1.6e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA21237.1 - 2e-07 31.2 0.1 5.5e-06 26.6 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EEA21237.1 - 0.00021 21.0 0.2 0.00072 19.4 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA21237.1 - 0.16 12.2 0.0 0.75 10.0 0.0 2.1 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Integrase_H2C2 PF17921.1 EEA21237.1 - 0.87 9.7 8.7 0.45 10.7 0.1 3.5 3 0 0 3 3 3 0 Integrase zinc binding domain MFS_1 PF07690.16 EEA21238.1 - 1e-44 152.9 41.8 5.6e-44 150.5 41.8 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA21238.1 - 5.4e-20 71.4 13.5 6e-20 71.2 11.7 1.7 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA21238.1 - 1e-12 47.7 10.8 1e-12 47.7 10.8 2.4 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 EEA21238.1 - 0.35 9.2 14.7 0.013 13.9 2.7 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector AA_permease_2 PF13520.6 EEA21239.1 - 1.2e-32 113.3 29.6 3.8e-20 72.1 6.5 2.0 1 1 1 2 2 2 2 Amino acid permease Acetyltransf_1 PF00583.25 EEA21240.1 - 4.4e-08 33.4 0.0 5.7e-08 33.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA21240.1 - 1.3e-07 31.6 0.0 3.2e-07 30.3 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA21240.1 - 5.3e-07 30.0 0.0 8.1e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA21240.1 - 0.0028 17.7 0.3 0.34 11.0 0.0 3.0 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain TPR_9 PF13371.6 EEA21240.1 - 0.018 15.2 0.2 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat MOZ_SAS PF01853.18 EEA21240.1 - 0.24 11.1 0.0 0.31 10.7 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family Glyco_hydro_28 PF00295.17 EEA21242.1 - 2.4e-100 335.8 17.3 2.4e-100 335.8 17.3 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 28 Pectinesterase PF01095.19 EEA21242.1 - 2e-41 141.6 0.4 2e-41 141.6 0.4 3.0 3 0 0 3 3 3 2 Pectinesterase PhyH PF05721.13 EEA21244.1 - 1.8e-22 80.7 0.0 2.2e-22 80.3 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 EEA21244.1 - 0.014 16.2 0.1 0.024 15.5 0.1 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EEA21244.1 - 0.015 15.7 0.1 0.026 14.9 0.1 1.5 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase MFS_1 PF07690.16 EEA21245.1 - 2.1e-15 56.6 34.3 3.2e-09 36.2 16.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ni_hydr_CYTB PF01292.20 EEA21245.1 - 0.0082 15.8 1.9 0.01 15.5 0.2 2.0 1 1 1 2 2 2 1 Prokaryotic cytochrome b561 SBF PF01758.16 EEA21245.1 - 0.019 14.7 1.0 0.056 13.1 0.1 2.2 2 0 0 2 2 2 0 Sodium Bile acid symporter family PALP PF00291.25 EEA21247.1 - 9.1e-55 186.1 0.0 1.2e-54 185.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.28 EEA21247.1 - 0.0084 15.8 0.0 0.017 14.8 0.0 1.8 1 1 1 2 2 2 1 Peptidase family M20/M25/M40 AA_permease PF00324.21 EEA21248.1 - 8.2e-110 367.6 40.1 1e-109 367.3 40.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA21248.1 - 2.1e-26 92.7 42.5 2.6e-26 92.4 42.5 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2101 PF09874.9 EEA21248.1 - 0.31 10.7 9.8 1.2 8.8 0.2 3.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2101) Glyco_hydro_28 PF00295.17 EEA21249.1 - 3e-21 75.9 3.0 4e-21 75.4 3.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 EEA21249.1 - 0.0002 21.3 12.7 0.00067 19.6 9.6 2.9 1 1 1 2 2 2 1 Pectate lyase superfamily protein 4HBT_2 PF13279.6 EEA21250.1 - 9e-07 29.4 0.1 1.8e-06 28.5 0.1 1.5 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_transf_3 PF01757.22 EEA21251.1 - 9.5e-30 103.8 44.8 1.1e-28 100.3 44.8 2.0 1 1 0 1 1 1 1 Acyltransferase family Fringe PF02434.16 EEA21252.1 - 3.4e-07 30.0 0.7 1e-05 25.1 0.9 2.6 2 1 0 2 2 2 1 Fringe-like PAN_4 PF14295.6 EEA21252.1 - 0.0026 17.6 1.9 0.0057 16.5 1.9 1.5 1 0 0 1 1 1 1 PAN domain DUF604 PF04646.12 EEA21252.1 - 0.037 13.4 0.1 0.069 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF604 Glyco_trans_2_3 PF13632.6 EEA21253.1 - 2.6e-09 37.3 2.9 2.6e-09 37.3 2.9 2.0 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EEA21253.1 - 2.9e-06 27.3 0.1 7e-06 26.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 EEA21253.1 - 2.9e-06 26.2 4.7 1.5e-05 23.9 1.1 2.8 2 1 0 2 2 2 1 Chitin synthase Glyco_transf_21 PF13506.6 EEA21253.1 - 1.1e-05 25.0 0.1 6.7e-05 22.4 0.1 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 21 Amidase PF01425.21 EEA21256.1 - 1.2e-99 334.3 0.0 1.7e-99 333.8 0.0 1.2 1 0 0 1 1 1 1 Amidase DUF807 PF05660.11 EEA21256.1 - 0.17 11.9 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) Terpene_synth_C PF03936.16 EEA21257.1 - 1.9e-11 43.9 0.1 3.6e-11 42.9 0.1 1.4 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain TRI5 PF06330.11 EEA21257.1 - 0.022 13.6 0.3 0.037 12.9 0.1 1.5 2 0 0 2 2 2 0 Trichodiene synthase (TRI5) p450 PF00067.22 EEA21258.1 - 1.6e-34 119.5 0.0 2.2e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Caps_synth PF05704.12 EEA21259.1 - 1.9e-11 43.9 1.6 2.1e-11 43.7 0.1 1.7 2 1 0 2 2 2 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 EEA21259.1 - 0.00037 21.1 0.1 0.001 19.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EEA21259.1 - 0.18 11.1 0.2 0.65 9.2 0.0 1.9 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Pribosyl_synth PF14572.6 EEA21260.1 - 5.1e-42 144.0 1.5 1.5e-36 126.1 0.2 2.7 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EEA21260.1 - 9.9e-42 141.6 0.0 2.4e-41 140.3 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EEA21260.1 - 7.7e-13 48.3 0.2 1.7e-12 47.2 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EEA21260.1 - 0.0049 16.3 0.1 0.0077 15.7 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyl_synth PF14572.6 EEA21261.1 - 1.8e-42 145.5 0.9 1e-36 126.7 0.2 2.6 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EEA21261.1 - 6.6e-13 48.5 0.2 1.2e-12 47.7 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EEA21261.1 - 0.003 17.1 0.0 0.0053 16.2 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran_N PF13793.6 EEA21261.1 - 0.032 14.2 0.1 0.099 12.6 0.0 1.9 2 0 0 2 2 2 0 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran_N PF13793.6 EEA21262.1 - 6.1e-42 142.2 0.1 2e-41 140.6 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EEA21262.1 - 2.1e-26 93.1 1.8 6.6e-21 75.2 0.3 2.7 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EEA21262.1 - 6.5e-13 48.5 0.2 1.3e-12 47.5 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EEA21262.1 - 0.0036 16.8 0.0 0.0055 16.2 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran_N PF13793.6 EEA21263.1 - 1.1e-41 141.5 0.0 2.5e-41 140.2 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EEA21263.1 - 3.4e-32 112.0 4.0 3.5e-27 95.6 1.2 2.7 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EEA21263.1 - 8.3e-13 48.2 0.2 1.8e-12 47.1 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EEA21263.1 - 0.005 16.3 0.1 0.008 15.6 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Glyco_hydro_76 PF03663.14 EEA21264.1 - 1.5e-46 159.6 9.8 1.5e-46 159.6 9.8 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EEA21264.1 - 0.00011 21.4 0.6 0.14 11.2 0.0 3.1 1 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 EEA21264.1 - 0.036 13.6 0.1 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus HTH_Tnp_Tc5 PF03221.16 EEA21265.1 - 1.6e-14 53.7 0.5 1e-13 51.1 0.0 2.5 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 EEA21265.1 - 7.8e-14 51.7 0.1 2.8e-13 49.9 0.0 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease COesterase PF00135.28 EEA21266.1 - 2.2e-16 59.8 0.0 3.1e-09 36.2 0.0 2.9 2 1 1 3 3 3 3 Carboxylesterase family AA_permease PF00324.21 EEA21267.1 - 2.8e-137 458.2 38.4 3.4e-137 457.9 38.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA21267.1 - 1.7e-36 126.0 41.8 2.2e-36 125.6 41.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EEA21267.1 - 0.08 11.7 0.1 0.15 10.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) tRNA-synt_2c PF01411.19 EEA21268.1 - 2.6e-06 26.2 0.2 3.3e-06 25.9 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EEA21268.1 - 0.00014 21.9 0.1 0.00036 20.6 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Acetyltransf_7 PF13508.7 EEA21269.1 - 9.2e-09 35.6 0.0 1.6e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA21269.1 - 4.5e-07 30.1 0.0 8.1e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA21269.1 - 4.6e-05 23.3 0.0 0.0001 22.2 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA21269.1 - 0.005 16.8 0.2 0.021 14.8 0.1 2.0 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EEA21269.1 - 0.062 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FAD_binding_4 PF01565.23 EEA21270.1 - 7e-31 106.8 6.3 1.3e-30 106.0 6.3 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA21270.1 - 1.2e-06 28.5 1.8 1.2e-06 28.5 1.8 1.9 2 0 0 2 2 2 1 Berberine and berberine like NAD_Gly3P_dh_N PF01210.23 EEA21270.1 - 0.04 13.9 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_4 PF01565.23 EEA21271.1 - 4e-31 107.6 7.0 9.1e-31 106.5 6.5 1.9 2 0 0 2 2 2 1 FAD binding domain FAD_binding_4 PF01565.23 EEA21272.1 - 5.2e-31 107.2 6.5 9.1e-31 106.5 6.5 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA21272.1 - 1.1e-06 28.7 1.8 1.1e-06 28.7 1.8 1.9 2 0 0 2 2 2 1 Berberine and berberine like Cu-oxidase_3 PF07732.15 EEA21273.1 - 1.8e-38 131.2 2.7 1.8e-38 131.2 2.7 2.6 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA21273.1 - 1.6e-37 128.3 11.4 9.2e-37 125.8 0.1 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EEA21273.1 - 2.7e-35 121.8 1.5 1.4e-34 119.5 0.4 2.3 2 0 0 2 2 2 1 Multicopper oxidase NUDIX PF00293.28 EEA21275.1 - 4.3e-21 75.3 0.1 5e-21 75.1 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain HsbA PF12296.8 EEA21276.1 - 1.2e-18 67.6 0.0 3.1e-18 66.3 0.0 1.6 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Hex_IIIa PF02455.16 EEA21276.1 - 0.021 13.6 1.8 0.23 10.2 0.0 2.0 2 0 0 2 2 2 0 Hexon-associated protein (IIIa) MFS_1 PF07690.16 EEA21277.1 - 2.6e-42 145.0 50.3 5.1e-42 144.1 49.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA21277.1 - 1.6e-17 63.2 27.5 2.1e-15 56.2 27.5 2.2 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA21277.1 - 4.5e-10 39.0 13.3 4.5e-10 39.0 13.3 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter Mpv17_PMP22 PF04117.12 EEA21277.1 - 0.0023 18.1 0.0 0.013 15.7 0.0 2.3 1 0 0 1 1 1 1 Mpv17 / PMP22 family CRM1_repeat_3 PF18787.1 EEA21277.1 - 0.11 12.7 0.7 0.27 11.4 0.1 2.0 2 0 0 2 2 2 0 CRM1 / Exportin repeat 3 Glyco_hydro_76 PF03663.14 EEA21278.1 - 1.4e-133 446.0 18.3 1.6e-133 445.7 18.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EEA21278.1 - 0.52 9.3 9.0 1.2 8.1 0.5 2.7 3 0 0 3 3 3 0 Glycosyl Hydrolase Family 88 FAD_binding_3 PF01494.19 EEA21279.1 - 6.5e-18 65.1 0.0 9.1e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA21279.1 - 0.00051 19.4 0.0 0.057 12.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA21279.1 - 0.0037 16.9 0.3 0.17 11.4 0.1 2.6 2 1 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA21279.1 - 0.018 15.6 0.0 0.24 12.0 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA21279.1 - 0.094 11.8 0.1 0.17 10.9 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Aldo_ket_red PF00248.21 EEA21280.1 - 1.3e-42 146.0 0.0 2.6e-42 145.0 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family HTH_23 PF13384.6 EEA21280.1 - 0.064 13.1 0.6 0.39 10.6 0.1 2.4 2 0 0 2 2 2 0 Homeodomain-like domain DUF3251 PF11622.8 EEA21280.1 - 0.096 12.3 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Aldo_ket_red PF00248.21 EEA21281.1 - 1.3e-42 146.0 0.0 2.6e-42 145.0 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family HTH_23 PF13384.6 EEA21281.1 - 0.064 13.1 0.6 0.39 10.6 0.1 2.4 2 0 0 2 2 2 0 Homeodomain-like domain DUF3251 PF11622.8 EEA21281.1 - 0.096 12.3 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Glyco_hydro_6 PF01341.17 EEA21282.1 - 6.4e-107 357.8 1.4 8.6e-107 357.4 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 CBM_1 PF00734.18 EEA21282.1 - 2.8e-12 46.4 14.2 2.8e-12 46.4 14.2 2.5 3 0 0 3 3 3 1 Fungal cellulose binding domain MGC-24 PF05283.11 EEA21282.1 - 0.14 12.6 15.1 0.43 11.0 15.1 1.8 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF4680 PF15730.5 EEA21282.1 - 7.8 6.8 8.5 15 5.9 8.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) Epimerase PF01370.21 EEA21283.1 - 2.2e-18 66.6 0.2 5.3e-17 62.1 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA21283.1 - 1e-10 41.1 0.0 1.5e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EEA21283.1 - 8.4e-07 29.1 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EEA21283.1 - 4.8e-06 26.2 0.0 1.2e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EEA21283.1 - 0.00013 21.2 0.6 0.0004 19.6 0.6 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EEA21283.1 - 0.0014 17.9 0.6 0.0046 16.1 0.6 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DapB_N PF01113.20 EEA21283.1 - 0.007 16.5 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EEA21283.1 - 0.01 16.2 0.0 0.017 15.5 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 EEA21283.1 - 0.016 14.8 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family DUF4772 PF15997.5 EEA21284.1 - 0.13 12.8 0.0 0.22 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4772) Glyco_hydro_88 PF07470.13 EEA21286.1 - 5.3e-29 101.4 0.0 5.9e-29 101.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Myb_DNA-binding PF00249.31 EEA21287.1 - 1.3e-25 89.3 1.8 2.1e-14 53.4 0.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA21287.1 - 2.1e-18 66.3 3.9 1.1e-14 54.4 0.1 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2774 PF11242.8 EEA21287.1 - 0.0088 16.2 0.0 0.042 14.0 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2774) SLIDE PF09111.10 EEA21287.1 - 0.026 14.5 0.0 0.094 12.7 0.0 1.9 1 1 1 2 2 2 0 SLIDE DUF3701 PF12482.8 EEA21287.1 - 0.098 12.7 0.3 0.31 11.1 0.1 1.9 2 0 0 2 2 2 0 Phage integrase protein NCBP3 PF10309.9 EEA21288.1 - 2e-21 75.6 0.1 3.5e-21 74.8 0.1 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 WD40 PF00400.32 EEA21289.1 - 0.0044 17.8 2.3 3.9 8.5 0.1 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA21289.1 - 0.013 15.8 0.3 0.3 11.4 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EEA21289.1 - 0.034 14.1 0.0 0.086 12.8 0.0 1.7 1 0 0 1 1 1 0 LisH WD40_like PF17005.5 EEA21289.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain ATP-synt_DE_N PF02823.16 EEA21290.1 - 3.3e-17 62.1 0.0 5e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_DE_N PF02823.16 EEA21291.1 - 4.6e-17 61.7 0.0 6.9e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Ribosomal_L29e PF01779.17 EEA21292.1 - 2.2e-22 79.1 9.0 3.7e-22 78.4 9.0 1.4 1 0 0 1 1 1 1 Ribosomal L29e protein family Phos_pyr_kin PF08543.12 EEA21293.1 - 8.5e-11 41.7 0.0 1.4e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EEA21293.1 - 9.8e-06 25.1 0.9 5.6e-05 22.6 0.9 2.3 1 1 0 1 1 1 1 pfkB family carbohydrate kinase FBPase_3 PF01950.16 EEA21293.1 - 0.081 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Fructose-1,6-bisphosphatase Mago-bind PF09282.10 EEA21293.1 - 0.22 11.4 0.4 0.47 10.4 0.4 1.5 1 0 0 1 1 1 0 Mago binding dUTPase PF00692.19 EEA21294.1 - 7.4e-44 148.6 0.0 9.5e-44 148.2 0.0 1.1 1 0 0 1 1 1 1 dUTPase DCD PF06559.11 EEA21294.1 - 0.024 13.4 0.0 0.034 12.9 0.0 1.1 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) APH PF01636.23 EEA21295.1 - 1.5e-45 156.0 0.0 2.5e-45 155.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA21295.1 - 5.8e-07 29.3 0.0 9e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EEA21295.1 - 0.00031 20.4 0.0 0.0023 17.6 0.0 2.0 2 0 0 2 2 2 1 RIO1 family EcKinase PF02958.20 EEA21295.1 - 0.00082 18.8 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EEA21295.1 - 0.0022 16.9 0.0 0.053 12.4 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) Kdo PF06293.14 EEA21295.1 - 0.021 14.2 0.0 0.078 12.3 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2 PF00096.26 EEA21296.1 - 1.2e-06 28.6 11.0 0.0091 16.4 2.6 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA21296.1 - 0.0083 16.5 18.2 0.8 10.2 0.2 5.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA21296.1 - 0.022 15.6 10.3 0.17 12.8 2.2 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 EEA21296.1 - 0.049 13.9 6.0 0.21 11.9 1.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EEA21297.1 - 3e-06 27.4 7.3 0.0028 18.0 0.1 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 EEA21297.1 - 0.00039 21.0 3.9 0.13 12.9 0.1 2.7 2 1 0 2 2 2 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EEA21297.1 - 0.0018 19.0 12.3 0.13 13.2 0.1 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger DUF2475 PF10629.9 EEA21297.1 - 0.0051 17.0 7.1 0.043 14.0 0.7 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF2475) PQ-loop PF04193.14 EEA21298.1 - 1.4e-36 124.0 7.1 1.4e-17 63.2 3.6 2.6 2 0 0 2 2 2 2 PQ loop repeat Cytochrom_B561 PF03188.16 EEA21299.1 - 1.9e-07 31.3 8.1 4e-07 30.3 8.1 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF202 PF02656.15 EEA21299.1 - 0.22 12.0 0.0 0.22 12.0 0.0 4.2 7 0 0 7 7 7 0 Domain of unknown function (DUF202) DUF4079 PF13301.6 EEA21299.1 - 7.3 6.7 11.7 26 5.0 7.9 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) Fungal_trans PF04082.18 EEA21300.1 - 3.2e-17 62.5 0.2 7.9e-17 61.2 0.2 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21300.1 - 0.00011 22.3 6.3 0.0002 21.4 6.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Afi1 PF07792.12 EEA21302.1 - 1e-46 158.7 1.2 1.8e-46 157.9 1.2 1.4 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EEA21302.1 - 5.2e-37 126.3 0.0 8.3e-37 125.6 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EEA21302.1 - 2.6e-08 33.0 0.0 0.0036 16.1 0.0 3.4 2 1 1 3 3 3 2 Transport protein Avl9 DUF1168 PF06658.12 EEA21302.1 - 0.013 15.3 4.6 0.028 14.3 4.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DUF2347 PF09804.9 EEA21302.1 - 0.17 11.5 0.0 0.52 9.8 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) EF-hand_6 PF13405.6 EEA21303.1 - 3.4e-12 45.2 2.0 4.9e-05 22.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EEA21303.1 - 1.2e-09 37.0 2.3 0.00098 18.5 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EEA21303.1 - 1.6e-08 34.9 0.2 0.0028 18.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA21303.1 - 5.5e-05 22.5 4.6 0.0082 15.6 0.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EEA21303.1 - 0.00019 21.2 0.7 0.95 9.4 0.0 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 EEA21303.1 - 0.00032 21.0 0.0 1.3 9.5 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain PHO4 PF01384.20 EEA21304.1 - 1.5e-101 339.8 20.8 1.8e-101 339.6 20.8 1.0 1 0 0 1 1 1 1 Phosphate transporter family RabGAP-TBC PF00566.18 EEA21305.1 - 9.6e-28 97.3 0.0 2.4e-23 82.9 0.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain SET PF00856.28 EEA21306.1 - 1.7e-09 38.3 0.0 5.3e-08 33.4 0.0 2.6 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 EEA21306.1 - 0.0034 17.4 5.2 0.0034 17.4 5.2 2.3 2 0 0 2 2 2 1 MYND finger TPR_9 PF13371.6 EEA21306.1 - 0.024 14.8 0.3 0.057 13.6 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 EEA21306.1 - 0.082 12.6 0.6 0.24 11.1 0.6 1.9 1 0 0 1 1 1 0 TPR repeat WD40 PF00400.32 EEA21307.1 - 4.9e-19 68.3 12.0 3.6e-05 24.4 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA21307.1 - 2.7e-05 24.4 0.0 0.031 14.6 0.0 3.9 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 EEA21307.1 - 0.029 12.6 0.5 2.7 6.0 0.1 2.3 2 0 0 2 2 2 0 CRT10 Glucosamine_iso PF01182.20 EEA21309.1 - 5.1e-71 239.1 0.0 5.7e-71 239.0 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase adh_short_C2 PF13561.6 EEA21310.1 - 4.4e-47 160.6 0.4 5.4e-47 160.3 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA21310.1 - 1.8e-37 128.7 1.4 2.4e-37 128.3 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA21310.1 - 0.00079 19.4 0.0 0.0011 18.9 0.0 1.2 1 0 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.21 EEA21310.1 - 0.014 15.4 0.4 0.023 14.7 0.4 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 EEA21310.1 - 0.02 14.8 0.5 0.029 14.2 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EEA21310.1 - 0.043 13.1 0.3 0.083 12.2 0.3 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Fungal_trans_2 PF11951.8 EEA21311.1 - 2.2e-12 46.5 0.3 4.2e-12 45.6 0.2 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain RNase_H PF00075.24 EEA21312.1 - 3.7e-20 72.6 0.0 6.1e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 RNase H Reo_sigmaC_M PF17750.1 EEA21313.1 - 0.02 14.7 0.1 0.04 13.8 0.1 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein triple beta spiral Hemerythrin PF01814.23 EEA21314.1 - 1.6e-14 54.6 0.5 2.6e-14 53.9 0.5 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Aminotran_1_2 PF00155.21 EEA21315.1 - 0.0035 16.6 0.0 0.11 11.6 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II RRM_1 PF00076.22 EEA21316.1 - 4.3e-11 42.5 0.0 2.9e-05 23.8 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MA3 PF02847.17 EEA21317.1 - 2.7e-29 101.4 0.0 7.5e-29 100.0 0.0 1.8 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 EEA21317.1 - 5.1e-12 45.9 0.1 9.3e-12 45.0 0.1 1.4 1 0 0 1 1 1 1 MIF4G domain DPM2 PF07297.12 EEA21318.1 - 2e-30 104.9 0.8 2.3e-30 104.7 0.8 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EEA21318.1 - 0.00094 19.1 0.7 0.0011 18.9 0.7 1.1 1 0 0 1 1 1 1 PIG-P DUF4229 PF14012.6 EEA21318.1 - 0.0078 16.3 0.2 0.0078 16.3 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) COX14 PF14880.6 EEA21318.1 - 0.0078 16.0 1.6 0.026 14.4 0.1 2.0 2 0 0 2 2 2 1 Cytochrome oxidase c assembly PilX_N PF14341.6 EEA21318.1 - 0.22 11.5 1.9 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 PilX N-terminal LapA_dom PF06305.11 EEA21318.1 - 0.27 11.1 0.1 0.27 11.1 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DPM2 PF07297.12 EEA21319.1 - 5.2e-28 97.2 0.8 6e-28 97.0 0.8 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EEA21319.1 - 0.0023 17.8 0.8 0.0025 17.7 0.8 1.1 1 0 0 1 1 1 1 PIG-P DUF4229 PF14012.6 EEA21319.1 - 0.0043 17.1 1.6 0.0055 16.8 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) COX14 PF14880.6 EEA21319.1 - 0.0051 16.6 1.3 0.02 14.7 0.1 1.9 2 0 0 2 2 2 1 Cytochrome oxidase c assembly LapA_dom PF06305.11 EEA21319.1 - 0.11 12.4 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain NFACT-R_2 PF18297.1 EEA21320.1 - 0.065 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 NFACT protein RNA binding domain HD PF01966.22 EEA21321.1 - 0.0015 18.7 2.6 0.0024 18.1 0.3 2.1 2 0 0 2 2 2 1 HD domain RMI1_C PF16099.5 EEA21321.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold Dynamin_N PF00350.23 EEA21322.1 - 4.1e-32 111.6 0.0 1e-31 110.2 0.0 1.8 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EEA21322.1 - 2.4e-30 105.8 5.1 4.3e-30 104.9 3.8 2.0 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EEA21322.1 - 0.00011 22.2 0.0 0.0005 20.1 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EEA21322.1 - 0.0028 17.8 0.8 0.018 15.2 0.2 2.7 2 0 0 2 2 2 1 Dynamin GTPase effector domain PriX PF18689.1 EEA21322.1 - 0.061 13.7 0.9 0.8 10.1 0.0 3.0 3 0 0 3 3 3 0 Primase X Abhydrolase_2 PF02230.16 EEA21323.1 - 1.6e-23 83.7 0.0 8.5e-15 55.2 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EEA21323.1 - 0.00033 20.2 0.0 0.0008 18.9 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family TFIIA PF03153.13 EEA21323.1 - 0.00085 19.4 8.4 0.0011 19.1 8.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Abhydrolase_6 PF12697.7 EEA21323.1 - 0.014 16.0 0.0 0.054 14.1 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA21323.1 - 0.058 12.7 0.1 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Nop14 PF04147.12 EEA21323.1 - 0.37 8.9 16.8 0.49 8.5 16.8 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EEA21323.1 - 2.8 7.2 15.7 3.7 6.8 15.7 1.1 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 EEA21323.1 - 4.1 6.9 14.9 6.1 6.3 14.9 1.2 1 0 0 1 1 1 0 PPP4R2 Helicase_C PF00271.31 EEA21325.1 - 1e-19 70.9 0.3 5.4e-19 68.6 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA21325.1 - 4.6e-19 69.1 0.0 9.5e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA21325.1 - 1.3e-14 54.4 0.0 3.4e-14 53.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EEA21325.1 - 0.023 14.4 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 EEA21325.1 - 0.025 13.8 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UIM PF02809.20 EEA21325.1 - 0.051 13.5 0.4 0.15 12.0 0.4 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif AAA_22 PF13401.6 EEA21325.1 - 0.09 13.1 0.0 0.27 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain OAD_gamma PF04277.13 EEA21325.1 - 6.3 7.5 5.4 17 6.1 0.0 3.6 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain F_actin_cap_B PF01115.17 EEA21326.1 - 1.1e-105 352.5 0.0 1.3e-105 352.3 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 EEA21326.1 - 0.066 12.6 0.0 0.19 11.2 0.0 1.8 1 1 1 2 2 2 0 F-actin capping protein alpha subunit Med11 PF10280.9 EEA21327.1 - 3.8e-44 150.5 0.2 4.6e-44 150.2 0.2 1.1 1 0 0 1 1 1 1 Mediator complex protein WD40 PF00400.32 EEA21328.1 - 2.7e-43 145.1 22.8 5.7e-09 36.5 0.1 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EEA21328.1 - 8.6e-41 139.2 0.1 1.3e-40 138.7 0.1 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EEA21328.1 - 4.4e-10 39.7 0.5 0.011 16.0 0.0 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EEA21328.1 - 6.5e-07 29.1 0.0 1.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 LisH Nup160 PF11715.8 EEA21328.1 - 0.00017 20.4 1.1 0.17 10.5 0.0 3.3 3 1 0 3 3 3 2 Nucleoporin Nup120/160 DUF4550 PF15084.6 EEA21328.1 - 0.1 13.0 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4550) Abhydrolase_6 PF12697.7 EEA21329.1 - 1.3e-20 75.0 0.2 2.2e-20 74.2 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA21329.1 - 5.2e-05 23.0 0.1 0.00019 21.2 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA21329.1 - 0.012 14.9 0.1 0.019 14.3 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EEA21329.1 - 0.092 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2417 PF10329.9 EEA21330.1 - 2.6e-84 282.4 2.2 3.8e-84 281.8 2.2 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) FA_desaturase PF00487.24 EEA21330.1 - 0.08 12.8 4.5 1.3 8.8 0.5 2.5 2 1 0 3 3 3 0 Fatty acid desaturase Trp_oprn_chp PF09534.10 EEA21330.1 - 0.27 11.0 2.0 0.3 10.9 0.5 1.7 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) AC_N PF16214.5 EEA21330.1 - 2.9 6.9 5.4 4.6 6.3 5.4 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region NPL4 PF05021.15 EEA21331.1 - 1.1e-139 465.0 0.0 1.4e-139 464.7 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EEA21331.1 - 1.3e-68 229.7 0.0 2.1e-68 229.0 0.0 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EEA21331.1 - 0.00016 22.1 0.0 0.00058 20.3 0.0 2.0 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 Flavodoxin_2 PF02525.17 EEA21332.1 - 8.9e-08 32.1 0.0 1.2e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EEA21332.1 - 1.3e-06 28.3 0.0 1.7e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 EEA21332.1 - 6.3e-05 23.2 0.1 0.0032 17.7 0.1 2.3 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EEA21332.1 - 0.04 14.2 0.0 0.24 11.6 0.0 1.9 1 1 1 2 2 2 0 Flavodoxin domain Flavodoxin_2 PF02525.17 EEA21333.1 - 6.2e-08 32.6 0.0 7.6e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EEA21333.1 - 9.2e-07 28.7 0.0 1.2e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 EEA21333.1 - 4.9e-05 23.6 0.2 0.0024 18.1 0.2 2.2 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EEA21333.1 - 0.029 14.6 0.0 0.19 12.0 0.0 1.9 1 1 1 2 2 2 0 Flavodoxin domain zf-CCCH PF00642.24 EEA21334.1 - 2.2e-15 56.1 37.3 2.4e-06 27.3 1.8 5.3 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EEA21334.1 - 6.2e-11 43.0 29.4 7.2e-05 23.4 1.1 5.3 1 1 4 5 5 5 5 Torus domain zf_CCCH_4 PF18345.1 EEA21334.1 - 7.6e-10 38.5 36.2 0.0036 17.3 2.5 5.2 5 0 0 5 5 5 4 Zinc finger domain zf-CCCH_4 PF18044.1 EEA21334.1 - 9.3e-05 22.1 2.3 9.3e-05 22.1 2.3 4.5 4 0 0 4 4 4 3 CCCH-type zinc finger Glyco_hydro_18 PF00704.28 EEA21335.1 - 1e-69 235.7 0.1 1.2e-69 235.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PNP_UDP_1 PF01048.20 EEA21336.1 - 0.00066 19.0 0.2 0.0026 17.0 0.2 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily DUF3712 PF12505.8 EEA21337.1 - 8.5e-32 110.1 1.8 8.5e-32 110.1 1.8 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3712) DUF2024 PF09630.10 EEA21337.1 - 0.015 15.2 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) LEA_2 PF03168.13 EEA21337.1 - 0.055 14.0 0.3 0.15 12.6 0.3 1.8 1 0 0 1 1 1 0 Late embryogenesis abundant protein Sel1 PF08238.12 EEA21338.1 - 4.3e-10 39.9 12.5 0.008 16.8 0.0 4.5 4 1 0 4 4 4 3 Sel1 repeat Far-17a_AIG1 PF04750.14 EEA21339.1 - 1.3e-10 40.9 21.3 2.1e-10 40.3 21.3 1.3 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Saf_2TM PF18303.1 EEA21339.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4381 PF14316.6 EEA21339.1 - 0.3 11.3 0.0 0.3 11.3 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) DUF2101 PF09874.9 EEA21339.1 - 2.7 7.6 0.0 2.7 7.6 0.0 3.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2101) Glyco_hydro_20 PF00728.22 EEA21340.1 - 1.7e-44 152.7 0.3 1.8e-43 149.3 0.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Aminotran_3 PF00202.21 EEA21342.1 - 2e-101 339.6 0.0 2.5e-101 339.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EEA21342.1 - 0.032 13.4 0.0 0.063 12.4 0.0 1.5 1 0 0 1 1 1 0 Aminotransferase class I and II ApbA_C PF08546.11 EEA21343.1 - 3.7e-29 101.4 0.0 6.9e-29 100.6 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EEA21343.1 - 1.2e-26 93.1 0.0 2.4e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Fungal_trans_2 PF11951.8 EEA21343.1 - 1.1e-23 83.7 0.1 1.6e-23 83.2 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain ThiF PF00899.21 EEA21343.1 - 0.21 10.9 3.2 0.37 10.1 1.3 2.3 3 0 0 3 3 3 0 ThiF family FMN_dh PF01070.18 EEA21344.1 - 4.5e-103 344.9 0.0 5.8e-103 344.6 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EEA21344.1 - 0.00014 21.0 0.1 0.00042 19.4 0.0 1.7 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EEA21344.1 - 0.00019 20.7 0.0 0.00032 20.0 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase MFS_1 PF07690.16 EEA21345.1 - 1.8e-33 116.0 35.0 3.5e-33 115.0 31.7 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily UL42 PF17638.2 EEA21345.1 - 0.036 14.0 0.6 7.7 6.5 0.0 3.3 3 0 0 3 3 3 0 HCMV UL42 DUF2583 PF10762.9 EEA21345.1 - 1.3 9.5 4.2 1.1 9.7 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2583) CorA PF01544.18 EEA21347.1 - 8.3e-06 25.3 0.3 1.8e-05 24.2 0.3 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein AAA PF00004.29 EEA21348.1 - 1.3e-08 35.3 0.0 2.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA21348.1 - 0.015 15.7 0.2 0.054 13.9 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EEA21348.1 - 0.075 13.3 0.0 0.23 11.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain Zot PF05707.12 EEA21348.1 - 0.1 12.2 0.0 0.36 10.4 0.0 1.9 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) His_Phos_2 PF00328.22 EEA21349.1 - 2e-24 86.7 0.0 3.4e-24 85.9 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF1776 PF08643.10 EEA21350.1 - 2.9e-97 325.6 0.0 3.6e-97 325.3 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 EEA21350.1 - 0.00012 21.6 0.0 0.0052 16.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21350.1 - 0.0046 16.5 0.0 0.32 10.5 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase EF-hand_1 PF00036.32 EEA21351.1 - 2.1e-40 133.3 11.9 1.2e-10 40.1 0.2 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA21351.1 - 1.3e-33 115.3 5.7 6.3e-17 61.8 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA21351.1 - 3.7e-33 110.6 6.9 1.4e-09 37.1 0.1 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EEA21351.1 - 1e-29 102.2 10.5 7.6e-14 51.3 0.7 3.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EEA21351.1 - 1.5e-24 84.4 10.7 1.1e-06 27.9 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EEA21351.1 - 3.7e-17 62.4 0.9 3.1e-09 37.0 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA21351.1 - 5e-11 42.5 0.7 0.00024 21.0 0.1 2.1 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 EEA21351.1 - 9.8e-08 32.8 0.1 0.0011 19.7 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EEA21351.1 - 1.9e-06 28.2 0.3 0.012 16.0 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EEA21351.1 - 2.7e-06 27.3 0.0 0.0027 17.7 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) DUF5580 PF17743.1 EEA21351.1 - 0.00052 18.7 0.0 0.00057 18.6 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) FGAR-AT_linker PF18072.1 EEA21351.1 - 0.0013 19.3 0.2 3.1 8.4 0.0 2.8 2 1 0 2 2 2 2 Formylglycinamide ribonucleotide amidotransferase linker domain VbhA PF18495.1 EEA21351.1 - 0.0022 17.8 2.7 1.1 9.2 0.1 4.0 5 0 0 5 5 4 1 Antitoxin VbhA DUF3349 PF11829.8 EEA21351.1 - 0.0025 18.5 0.7 0.44 11.3 0.1 2.4 1 1 0 2 2 2 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 EEA21351.1 - 0.0027 17.7 1.1 5.9 6.8 0.0 3.4 1 1 3 4 4 4 0 Caleosin related protein Dockerin_1 PF00404.18 EEA21351.1 - 0.0033 17.6 3.1 0.2 11.9 0.1 2.5 2 1 0 2 2 2 1 Dockerin type I domain TerB PF05099.13 EEA21351.1 - 0.0034 17.4 2.6 0.29 11.1 0.5 2.4 1 1 1 2 2 2 1 Tellurite resistance protein TerB EF-hand_14 PF17959.1 EEA21351.1 - 0.0052 17.1 0.1 1 9.8 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain EF-hand_10 PF14788.6 EEA21351.1 - 0.0063 16.4 1.5 0.012 15.5 0.1 2.2 3 0 0 3 3 2 1 EF hand RNA_pol_Rpb4 PF03874.16 EEA21351.1 - 0.0095 16.3 1.7 2.4 8.5 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb4 DUF1456 PF07308.13 EEA21351.1 - 0.011 16.0 0.6 0.61 10.5 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1456) Glycos_trans_3N PF02885.17 EEA21351.1 - 0.02 14.8 9.0 11 6.0 0.3 5.0 3 2 1 4 4 4 0 Glycosyl transferase family, helical bundle domain MotA_activ PF09114.10 EEA21351.1 - 0.046 13.9 0.1 13 6.0 0.0 2.2 1 1 0 2 2 2 0 Transcription factor MotA, activation domain MgtE_N PF03448.17 EEA21351.1 - 0.047 14.3 3.4 0.68 10.6 0.2 2.1 2 0 0 2 2 2 0 MgtE intracellular N domain Peptidase_M24 PF00557.24 EEA21351.1 - 0.09 12.5 0.2 3.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Metallopeptidase family M24 ApbA_C PF08546.11 EEA21351.1 - 0.094 12.9 0.2 1.6 8.9 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal DUF1296 PF06972.11 EEA21351.1 - 0.1 12.7 1.3 0.24 11.6 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) Phage_tail_S PF05069.13 EEA21351.1 - 0.14 12.0 0.3 1.6 8.6 0.0 2.4 2 1 1 3 3 3 0 Phage virion morphogenesis family DUF1707 PF08044.11 EEA21351.1 - 0.21 11.7 1.9 3.6 7.7 0.0 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF1707) DED PF01335.21 EEA21351.1 - 0.22 11.9 0.6 2.7 8.4 0.0 2.6 2 1 0 2 2 2 0 Death effector domain GPHH PF16905.5 EEA21351.1 - 0.23 11.3 0.1 24 4.8 0.0 3.1 4 0 0 4 4 4 0 Voltage-dependent L-type calcium channel, IQ-associated DUF533 PF04391.12 EEA21351.1 - 2.6 7.6 4.9 7.1 6.2 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF533) EF-hand_1 PF00036.32 EEA21352.1 - 2.1e-30 102.0 7.4 7.6e-11 40.8 0.2 3.1 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EEA21352.1 - 7.2e-26 89.8 6.6 4.1e-14 52.2 0.7 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 EEA21352.1 - 1.7e-25 89.3 3.7 3.2e-17 62.8 0.7 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA21352.1 - 1.5e-22 77.5 3.3 6e-08 32.0 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EEA21352.1 - 2.6e-18 64.6 4.9 6.7e-07 28.5 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 EEA21352.1 - 8.8e-13 48.4 0.9 1.3e-05 25.4 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA21352.1 - 5.6e-09 35.9 0.6 0.0002 21.3 0.1 2.1 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 EEA21352.1 - 7.3e-06 26.8 0.0 0.00047 21.0 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EEA21352.1 - 0.00059 20.1 0.1 0.0053 17.1 0.0 1.9 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 EEA21352.1 - 0.0014 17.2 0.0 0.0015 17.1 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_10 PF14788.6 EEA21352.1 - 0.003 17.4 0.3 0.0066 16.3 0.1 1.7 2 0 0 2 2 2 1 EF hand UPF0154 PF03672.13 EEA21352.1 - 0.0034 17.4 0.0 2.9 8.0 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 EEA21352.1 - 0.019 15.2 0.6 0.11 12.7 0.1 2.1 2 0 0 2 2 2 0 Dockerin type I domain FGAR-AT_linker PF18072.1 EEA21352.1 - 0.027 15.0 0.2 1.9 9.1 0.0 2.5 3 0 0 3 3 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain TerB PF05099.13 EEA21352.1 - 0.031 14.2 1.0 0.13 12.2 0.5 1.9 1 1 1 2 2 2 0 Tellurite resistance protein TerB DUF1296 PF06972.11 EEA21352.1 - 0.051 13.7 0.6 0.11 12.6 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) EF-hand_14 PF17959.1 EEA21352.1 - 0.069 13.5 0.2 0.54 10.6 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain Glycos_trans_3N PF02885.17 EEA21352.1 - 0.098 12.5 3.7 7 6.6 0.3 3.5 2 2 1 3 3 3 0 Glycosyl transferase family, helical bundle domain DUF1456 PF07308.13 EEA21352.1 - 0.11 12.9 0.5 0.35 11.2 0.1 1.9 3 0 0 3 3 2 0 Protein of unknown function (DUF1456) Amidase PF01425.21 EEA21353.1 - 4.1e-95 319.4 0.0 5.1e-95 319.1 0.0 1.1 1 0 0 1 1 1 1 Amidase UbiA PF01040.18 EEA21354.1 - 1.5e-32 112.9 17.2 5.5e-32 111.1 17.1 1.9 1 1 0 1 1 1 1 UbiA prenyltransferase family DUF2304 PF10066.9 EEA21354.1 - 0.46 10.7 2.5 0.51 10.6 0.7 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Deltameth_res PF16020.5 EEA21354.1 - 0.69 9.8 4.3 3.3 7.7 0.1 3.3 3 1 0 3 3 3 0 Deltamethrin resistance Kinesin PF00225.23 EEA21355.1 - 7.6e-52 176.3 0.0 2.5e-29 102.2 0.0 2.1 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 EEA21355.1 - 2.4e-12 47.0 0.0 4.5e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding baeRF_family11 PF18855.1 EEA21355.1 - 0.058 13.7 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 11 Zn_clus PF00172.18 EEA21357.1 - 6.3e-07 29.4 15.5 6.3e-07 29.4 15.5 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CitX PF03802.14 EEA21357.1 - 1.9 8.2 8.1 2.9 7.6 8.1 1.2 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase WLM PF08325.10 EEA21358.1 - 1.4e-66 224.2 0.1 2.2e-66 223.6 0.1 1.3 1 0 0 1 1 1 1 WLM domain zf-RanBP PF00641.18 EEA21358.1 - 0.00094 18.5 21.4 0.0011 18.3 4.6 3.2 2 1 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF45 PF01863.17 EEA21358.1 - 0.0027 17.8 3.2 0.0067 16.5 3.2 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF45 Stc1 PF12898.7 EEA21358.1 - 0.013 16.1 3.0 0.32 11.6 0.3 2.4 2 0 0 2 2 2 0 Stc1 domain DZR PF12773.7 EEA21358.1 - 0.071 13.2 9.0 0.88 9.6 9.1 2.2 1 1 1 2 2 2 0 Double zinc ribbon SprT-like PF10263.9 EEA21358.1 - 0.097 12.5 0.2 0.22 11.4 0.2 1.5 1 0 0 1 1 1 0 SprT-like family Peptidase_M54 PF07998.11 EEA21358.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 C1_2 PF03107.16 EEA21358.1 - 0.15 12.4 5.7 2.5 8.5 0.9 2.8 2 0 0 2 2 2 0 C1 domain FAD_binding_3 PF01494.19 EEA21359.1 - 3.3e-68 230.5 0.0 4.1e-68 230.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA21359.1 - 9e-06 25.5 0.2 6.3e-05 22.7 0.0 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA21359.1 - 4.5e-05 22.8 0.0 0.00019 20.8 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA21359.1 - 0.00028 20.4 0.0 0.00055 19.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Phe_hydrox_dim PF07976.12 EEA21359.1 - 0.00076 19.5 0.0 0.0018 18.3 0.0 1.7 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Thi4 PF01946.17 EEA21359.1 - 0.0012 18.1 0.0 0.0028 16.9 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 EEA21359.1 - 0.0015 17.4 0.0 0.003 16.5 0.0 1.5 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 EEA21359.1 - 0.0068 16.6 0.1 0.021 15.0 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA21359.1 - 0.0089 14.8 0.0 0.077 11.7 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EEA21359.1 - 0.0095 15.1 0.0 0.021 13.9 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EEA21359.1 - 0.087 13.4 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA21359.1 - 0.11 11.7 0.0 0.29 10.4 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA21359.1 - 0.12 11.4 0.0 0.26 10.3 0.0 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A Pkinase PF00069.25 EEA21362.1 - 3e-15 56.3 0.0 3e-14 53.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA21362.1 - 2.4e-05 23.7 0.1 0.088 12.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase DJ-1_PfpI PF01965.24 EEA21364.1 - 2.6e-11 43.6 0.0 3.5e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family HEPN-like_int PF18867.1 EEA21365.1 - 0.053 13.4 0.1 0.19 11.6 0.0 1.7 1 1 0 1 1 1 0 HEPN-like integron domain SpoIIE PF07228.12 EEA21366.1 - 5.8e-06 26.4 0.0 1.1e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EEA21366.1 - 7.9e-05 22.4 0.1 0.28 10.8 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EEA21366.1 - 0.0011 18.6 0.1 0.0017 18.1 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Mgm101p PF06420.12 EEA21366.1 - 0.14 11.7 0.1 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial genome maintenance MGM101 F-box-like PF12937.7 EEA21368.1 - 0.0014 18.5 1.5 0.0029 17.5 0.1 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EEA21368.1 - 0.0091 15.9 0.6 0.024 14.5 0.0 2.1 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 EEA21368.1 - 0.039 14.4 0.2 7.5 7.1 0.0 3.0 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) P34-Arc PF04045.14 EEA21369.1 - 4.7e-108 360.4 0.0 5.6e-108 360.2 0.0 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.12 EEA21369.1 - 0.071 12.7 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) WD40 PF00400.32 EEA21370.1 - 9.2e-55 181.4 25.6 1.2e-06 29.1 0.1 11.9 12 0 0 12 12 12 10 WD domain, G-beta repeat Utp12 PF04003.12 EEA21370.1 - 1.4e-21 76.8 0.2 2.8e-21 75.8 0.2 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EEA21370.1 - 3.3e-21 75.4 2.7 0.082 13.2 0.0 9.0 6 3 3 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA21370.1 - 1.1e-07 31.1 2.8 0.58 9.1 0.0 6.2 3 2 3 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EEA21370.1 - 3.3e-05 22.8 3.5 0.22 10.2 0.1 4.5 2 2 2 5 5 5 2 Nup133 N terminal like Nup160 PF11715.8 EEA21370.1 - 0.00023 19.9 9.1 0.021 13.5 0.0 5.2 5 2 1 7 7 7 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EEA21370.1 - 0.00028 20.3 0.0 2.5 7.3 0.0 3.8 4 0 0 4 4 4 2 WD40-like domain eIF2A PF08662.11 EEA21370.1 - 0.016 15.1 1.7 8.1 6.3 0.0 4.7 5 2 1 6 6 6 0 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EEA21370.1 - 0.021 13.2 0.0 0.93 7.7 0.0 2.5 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 EEA21370.1 - 0.076 12.7 0.2 2.7 7.6 0.0 3.3 4 0 0 4 4 4 0 TUP1-like enhancer of split Glyco_hydro_43 PF04616.14 EEA21371.1 - 1.4e-15 57.4 2.7 1.4e-14 54.1 2.5 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 MFS_1 PF07690.16 EEA21372.1 - 3.8e-16 59.0 54.7 1.3e-14 54.0 38.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA21372.1 - 5.3e-09 35.5 7.7 5.3e-09 35.5 7.7 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter Fcf1 PF04900.12 EEA21373.1 - 2.3e-16 60.0 0.1 6.7e-15 55.3 0.1 2.4 1 1 0 1 1 1 1 Fcf1 DUF4551 PF15087.6 EEA21373.1 - 1.4 7.7 9.4 1.8 7.3 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RR_TM4-6 PF06459.12 EEA21373.1 - 9.8 5.9 15.5 18 5.0 15.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cmc1 PF08583.10 EEA21374.1 - 8.8e-18 64.1 4.0 1.2e-17 63.7 4.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like WD40 PF00400.32 EEA21375.1 - 1.1e-15 57.8 3.5 0.00065 20.5 0.2 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 EEA21375.1 - 4.6e-06 25.6 1.5 0.0015 17.3 0.2 2.6 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EEA21375.1 - 5.2e-06 26.7 0.2 0.04 14.2 0.1 4.7 4 1 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4241 PF14025.6 EEA21375.1 - 0.064 13.5 2.4 0.15 12.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) RRN3 PF05327.11 EEA21378.1 - 1.2e-175 585.3 0.0 1.2e-175 585.3 0.0 2.0 1 1 1 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Abhydrolase_3 PF07859.13 EEA21379.1 - 1.1e-43 149.6 0.0 1.5e-43 149.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA21379.1 - 1.2e-09 37.6 0.1 4.2e-09 35.8 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 EEA21379.1 - 0.0021 17.9 0.0 0.007 16.2 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EEA21379.1 - 0.0068 15.9 0.0 1.5 8.3 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EEA21379.1 - 0.0095 16.6 0.7 0.018 15.6 0.7 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 EEA21379.1 - 0.017 14.7 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) AXE1 PF05448.12 EEA21379.1 - 0.059 12.0 0.1 1.3 7.6 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Lipase_3 PF01764.25 EEA21379.1 - 0.087 12.7 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Lipase (class 3) tRNA-synt_2 PF00152.20 EEA21380.1 - 1.2e-71 241.3 0.0 2e-71 240.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EEA21380.1 - 8.2e-20 71.0 0.0 1.3e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 EEA21380.1 - 0.002 18.1 0.0 0.0053 16.7 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EEA21380.1 - 0.06 12.8 0.1 7.3 6.0 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) DDE_Tnp_1_7 PF13843.6 EEA21381.1 - 1.4e-44 152.8 0.2 1.9e-44 152.4 0.2 1.1 1 0 0 1 1 1 1 Transposase IS4 DUF4470 PF14737.6 EEA21383.1 - 2.3e-10 40.5 0.1 4.8e-10 39.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) TPR_2 PF07719.17 EEA21383.1 - 6e-09 35.3 8.7 0.0015 18.5 0.7 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA21383.1 - 1.1e-06 28.2 4.3 0.023 14.5 0.6 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA21383.1 - 1.9e-05 25.1 4.1 0.2 12.2 0.7 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA21383.1 - 2.7e-05 24.6 11.5 0.18 12.7 0.8 4.8 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA21383.1 - 3e-05 23.6 6.1 0.00012 21.7 2.1 3.0 2 1 1 3 3 3 2 TPR repeat TPR_12 PF13424.6 EEA21383.1 - 8.2e-05 22.8 8.5 0.0018 18.5 4.1 3.8 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA21383.1 - 8.9e-05 23.1 2.2 8.9e-05 23.1 2.2 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA21383.1 - 0.0011 18.8 0.1 0.0011 18.8 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA21383.1 - 0.0013 18.8 0.1 5 7.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EEA21383.1 - 0.063 13.4 8.0 1.3 9.2 0.5 3.8 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 EEA21383.1 - 0.11 12.2 0.2 0.21 11.2 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 EEA21383.1 - 0.17 11.2 1.6 0.64 9.3 1.6 1.9 1 1 0 1 1 1 0 MalT-like TPR region TPR_6 PF13174.6 EEA21383.1 - 0.22 12.2 2.2 17 6.3 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EEA21383.1 - 2 9.0 3.9 2.9 8.5 0.2 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EEA21383.1 - 3.4 7.9 5.1 24 5.3 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat HLH PF00010.26 EEA21384.1 - 4.1e-13 49.1 1.6 5.7e-13 48.6 0.4 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain BID PF06393.11 EEA21384.1 - 0.12 11.9 3.7 0.15 11.6 0.0 2.3 2 0 0 2 2 2 0 BH3 interacting domain (BID) Septin PF00735.18 EEA21385.1 - 9.5e-13 48.1 0.0 9.4e-12 44.8 0.0 2.1 1 1 0 1 1 1 1 Septin AAA_16 PF13191.6 EEA21385.1 - 0.0009 19.7 0.2 0.0026 18.2 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 EEA21385.1 - 0.028 14.3 0.0 0.067 13.1 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 EEA21385.1 - 0.037 13.4 0.0 0.1 11.9 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EEA21385.1 - 0.042 13.6 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EEA21385.1 - 0.05 14.1 0.4 0.18 12.3 0.4 2.1 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EEA21385.1 - 0.056 13.6 0.3 0.21 11.8 0.0 2.1 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EEA21385.1 - 0.066 12.3 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATP_bind_1 PF03029.17 EEA21385.1 - 0.073 12.8 0.1 0.21 11.4 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF815 PF05673.13 EEA21385.1 - 0.11 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA PF00004.29 EEA21385.1 - 0.12 12.8 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Gtr1_RagA PF04670.12 EEA21385.1 - 0.12 11.7 0.1 5.7 6.2 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Zeta_toxin PF06414.12 EEA21385.1 - 0.16 11.2 0.0 0.37 10.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 EEA21385.1 - 0.17 11.9 0.0 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA21385.1 - 0.19 11.6 0.7 2.6 7.9 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase HSP90 PF00183.18 EEA21386.1 - 1.3e-222 740.3 34.0 1.7e-222 739.9 34.0 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EEA21386.1 - 1.1e-15 58.2 0.1 2e-15 57.3 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EEA21386.1 - 2.6e-12 46.7 0.1 8e-12 45.2 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1676 PF07898.13 EEA21386.1 - 0.89 9.6 4.3 0.89 9.6 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) NTF2 PF02136.20 EEA21387.1 - 4.5e-26 91.8 0.3 8e-26 91.0 0.3 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EEA21387.1 - 4.7e-08 32.7 0.0 8.2e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GFA PF04828.14 EEA21389.1 - 2.5e-10 40.6 0.3 2.5e-10 40.6 0.3 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Xylo_C PF12529.8 EEA21390.1 - 0.15 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Xylosyltransferase C terminal Fungal_trans PF04082.18 EEA21391.1 - 4.2e-10 39.1 0.0 8.4e-10 38.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 EEA21392.1 - 1.5e-21 76.7 0.1 1.8e-17 63.4 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21392.1 - 1.5e-15 57.4 0.0 1.1e-12 48.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA21392.1 - 1.4e-05 25.0 0.1 4.9e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 KR domain TPR_17 PF13431.6 EEA21393.1 - 2.6e-05 24.3 0.9 1.1 9.8 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA21393.1 - 0.00036 20.2 0.6 0.43 10.5 0.2 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA21393.1 - 0.0054 16.8 8.0 0.25 11.5 0.2 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA21393.1 - 0.011 15.9 3.0 0.51 10.7 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EEA21393.1 - 0.025 14.3 8.1 0.55 10.0 0.0 4.9 5 0 0 5 5 5 0 TPR repeat TPR_10 PF13374.6 EEA21393.1 - 0.095 12.6 0.9 10 6.2 0.9 3.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EEA21393.1 - 0.17 12.4 2.6 28 5.3 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA21393.1 - 0.18 12.1 9.7 8.2 6.8 1.0 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA21393.1 - 0.77 10.5 3.8 92 4.0 0.0 4.7 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA21393.1 - 0.79 10.7 12.2 3.4 8.8 0.2 5.5 6 2 0 6 6 5 0 Tetratricopeptide repeat DALR_2 PF09190.11 EEA21393.1 - 1.1 9.7 4.2 15 6.1 0.2 3.5 3 0 0 3 3 3 0 DALR domain FlgN PF05130.12 EEA21393.1 - 1.1 9.7 11.0 0.18 12.3 1.7 3.3 2 1 1 3 3 3 0 FlgN protein Nnf1 PF03980.14 EEA21394.1 - 9.3e-33 112.9 3.4 9.3e-33 112.9 3.4 2.2 2 1 1 3 3 3 1 Nnf1 WD-3 PF09765.9 EEA21394.1 - 0.083 12.2 2.0 0.39 10.0 0.9 2.0 1 1 1 2 2 2 0 WD-repeat region COG2 PF06148.11 EEA21394.1 - 0.86 9.7 4.7 5.5 7.1 3.3 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Dicty_CAR PF05462.11 EEA21395.1 - 6.1e-13 48.6 6.2 6.1e-13 48.6 6.2 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 EEA21395.1 - 5.7e-07 29.1 6.8 7.7e-07 28.7 6.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 EEA21395.1 - 6.6e-06 26.0 10.6 1.3e-05 25.1 10.6 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 EEA21395.1 - 0.00043 19.7 2.3 0.00077 18.9 2.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Lir1 PF07207.11 EEA21395.1 - 0.047 13.9 0.8 0.093 13.0 0.8 1.5 1 0 0 1 1 1 0 Light regulated protein Lir1 GPR_Gpa2_C PF11970.8 EEA21395.1 - 5.5 7.1 6.9 1.9 8.6 3.1 2.2 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Pkinase PF00069.25 EEA21396.1 - 3.5e-75 252.8 0.0 4.3e-75 252.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA21396.1 - 3.6e-37 128.1 0.0 5e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA21396.1 - 3.2e-05 23.1 0.1 0.0003 19.8 0.1 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EEA21396.1 - 0.0016 17.9 0.5 0.016 14.5 0.1 2.5 2 1 1 3 3 3 1 Kinase-like Kdo PF06293.14 EEA21396.1 - 0.016 14.6 0.4 0.016 14.6 0.4 1.9 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA21396.1 - 0.055 13.4 2.7 0.062 13.2 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EEA21396.1 - 0.085 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 SIR2 PF02146.17 EEA21397.1 - 3.7e-30 105.2 0.0 5.9e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Sir2 family Rimk_N PF18030.1 EEA21397.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 RimK PreATP-grasp domain Cation_efflux PF01545.21 EEA21398.1 - 2.4e-57 193.9 5.2 3.3e-57 193.5 5.2 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EEA21398.1 - 3.8e-05 23.7 0.1 7.7e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter UreE_C PF05194.12 EEA21398.1 - 6.8 7.3 24.7 12 6.5 3.8 3.7 3 1 0 3 3 3 0 UreE urease accessory protein, C-terminal domain FGGY_C PF02782.16 EEA21399.1 - 1.5e-31 109.7 0.0 3.3e-31 108.6 0.0 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EEA21399.1 - 3.8e-19 69.2 0.0 7.2e-12 45.4 0.0 2.4 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Xpo1 PF08389.12 EEA21400.1 - 1.2e-39 135.7 3.8 3.4e-39 134.3 0.0 3.4 4 1 1 5 5 5 1 Exportin 1-like protein HEAT PF02985.22 EEA21400.1 - 0.036 14.3 0.0 6.7 7.3 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat Amidase_3 PF01520.18 EEA21400.1 - 0.062 13.4 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase DUF4844 PF16133.5 EEA21400.1 - 0.12 12.9 0.4 12 6.5 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) Esterase PF00756.20 EEA21401.1 - 6e-50 170.2 0.0 7.4e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 EEA21401.1 - 7.2e-07 28.9 0.0 4.9e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EEA21401.1 - 1.8e-06 27.6 0.1 3.2e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA21401.1 - 0.00029 20.2 0.0 0.0012 18.1 0.0 1.9 2 1 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA21401.1 - 0.0013 18.6 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 EEA21401.1 - 0.011 14.4 0.0 0.016 13.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 EEA21401.1 - 0.012 15.4 0.0 0.041 13.7 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EEA21401.1 - 0.027 13.4 0.0 0.052 12.5 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 EEA21401.1 - 0.043 14.4 0.2 0.098 13.3 0.2 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA21401.1 - 0.087 12.5 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EEA21401.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Rotamase_2 PF13145.6 EEA21401.1 - 0.11 13.4 0.0 0.18 12.6 0.0 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain PAF-AH_p_II PF03403.13 EEA21401.1 - 0.11 11.0 0.0 0.23 9.9 0.0 1.5 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Lambda_Kil PF06301.11 EEA21401.1 - 0.11 12.1 0.6 2.4 7.8 0.3 2.5 3 0 0 3 3 3 0 Bacteriophage lambda Kil protein Chlorophyllase PF07224.11 EEA21401.1 - 0.17 10.9 0.0 0.36 9.8 0.0 1.5 2 0 0 2 2 2 0 Chlorophyllase PGAP1 PF07819.13 EEA21401.1 - 0.2 11.3 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 EEA21402.1 - 6e-50 170.2 0.0 7.4e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 EEA21402.1 - 7.2e-07 28.9 0.0 4.9e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EEA21402.1 - 1.8e-06 27.6 0.1 3.2e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA21402.1 - 0.00029 20.2 0.0 0.0012 18.1 0.0 1.9 2 1 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA21402.1 - 0.0013 18.6 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 EEA21402.1 - 0.011 14.4 0.0 0.016 13.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 EEA21402.1 - 0.012 15.4 0.0 0.041 13.7 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EEA21402.1 - 0.027 13.4 0.0 0.052 12.5 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 EEA21402.1 - 0.043 14.4 0.2 0.098 13.3 0.2 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA21402.1 - 0.087 12.5 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EEA21402.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Rotamase_2 PF13145.6 EEA21402.1 - 0.11 13.4 0.0 0.18 12.6 0.0 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain PAF-AH_p_II PF03403.13 EEA21402.1 - 0.11 11.0 0.0 0.23 9.9 0.0 1.5 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Lambda_Kil PF06301.11 EEA21402.1 - 0.11 12.1 0.6 2.4 7.8 0.3 2.5 3 0 0 3 3 3 0 Bacteriophage lambda Kil protein Chlorophyllase PF07224.11 EEA21402.1 - 0.17 10.9 0.0 0.36 9.8 0.0 1.5 2 0 0 2 2 2 0 Chlorophyllase PGAP1 PF07819.13 EEA21402.1 - 0.2 11.3 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Peptidase_C50 PF03568.17 EEA21403.1 - 1.7e-154 514.7 0.0 4.8e-154 513.3 0.0 1.8 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 EEA21403.1 - 0.00012 21.6 0.2 0.00092 18.7 0.0 2.5 3 0 0 3 3 3 1 CHAT domain TPR_1 PF00515.28 EEA21403.1 - 0.16 11.9 3.4 3.6 7.6 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 EEA21403.1 - 0.17 11.6 8.6 1.1 8.9 0.1 4.2 4 0 0 4 4 4 0 26S proteasome subunit RPN7 TPR_14 PF13428.6 EEA21403.1 - 0.47 11.4 9.2 6.7 7.8 0.2 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA21403.1 - 0.72 10.2 12.6 0.32 11.3 3.5 4.6 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA21403.1 - 4 7.8 12.6 18 5.8 0.3 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF5321 PF17254.2 EEA21404.1 - 1.7e-60 203.1 2.7 2.1e-60 202.8 2.7 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5321) MRI PF15325.6 EEA21404.1 - 0.083 14.0 2.5 0.13 13.3 2.5 1.3 1 0 0 1 1 1 0 Modulator of retrovirus infection Zn_clus PF00172.18 EEA21405.1 - 7.9e-06 25.9 11.3 1.6e-05 24.9 11.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldo_ket_red PF00248.21 EEA21406.1 - 8e-53 179.5 0.0 9.8e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DIMCO_N PF16844.5 EEA21406.1 - 0.1 12.9 0.0 4.3 7.7 0.0 2.4 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal Zn-ribbon_8 PF09723.10 EEA21407.1 - 0.031 14.4 3.1 0.29 11.3 1.0 2.6 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 EEA21407.1 - 0.09 12.8 0.9 2.2 8.4 0.5 2.3 2 0 0 2 2 2 0 Double zinc ribbon Auto_anti-p27 PF06677.12 EEA21407.1 - 3.4 7.9 4.9 3.6 7.8 0.6 2.8 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) AAA_12 PF13087.6 EEA21408.1 - 1.4e-40 139.0 0.0 4.2e-40 137.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EEA21408.1 - 4.2e-27 95.6 0.1 1.9e-26 93.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EEA21408.1 - 4.1e-10 40.2 0.0 1.5e-09 38.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA21408.1 - 3.5e-07 30.1 0.1 0.00031 20.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EEA21408.1 - 3.6e-05 23.2 0.6 0.063 12.5 0.1 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) zf-CCCH PF00642.24 EEA21408.1 - 0.0023 17.8 5.5 0.005 16.7 5.5 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Cyclase_polyket PF04673.12 EEA21408.1 - 0.007 16.6 0.0 0.027 14.7 0.0 2.0 1 0 0 1 1 1 1 Polyketide synthesis cyclase Adeno_IVa2 PF02456.15 EEA21408.1 - 0.0084 15.0 0.0 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Adenovirus IVa2 protein ResIII PF04851.15 EEA21408.1 - 0.016 15.2 0.1 0.041 13.9 0.1 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EEA21408.1 - 0.019 14.7 0.2 1.1 8.9 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EEA21408.1 - 0.042 12.9 0.0 0.087 11.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein FMO-like PF00743.19 EEA21409.1 - 7.6e-39 133.5 0.0 2.5e-22 79.0 0.0 3.0 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA21409.1 - 8.7e-17 61.3 0.0 6.6e-11 42.0 0.0 3.1 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA21409.1 - 8.5e-13 48.6 0.0 0.00018 21.2 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA21409.1 - 2e-12 47.0 0.0 7.7e-12 45.0 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA21409.1 - 3.1e-09 36.9 0.0 1.8e-08 34.5 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA21409.1 - 4.7e-09 36.4 0.1 2.2e-08 34.3 0.1 2.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EEA21409.1 - 3e-08 33.2 0.1 3e-06 26.6 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EEA21409.1 - 3.8e-07 29.6 0.0 0.00011 21.5 0.0 2.2 2 0 0 2 2 2 2 Thi4 family MCRA PF06100.11 EEA21409.1 - 0.00064 18.6 0.0 0.0043 15.9 0.0 2.1 2 0 0 2 2 2 1 MCRA family FAD_binding_2 PF00890.24 EEA21409.1 - 0.00074 18.7 0.1 0.037 13.1 0.2 2.2 1 1 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EEA21409.1 - 0.0011 17.7 0.0 0.0099 14.6 0.0 2.2 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox PF00070.27 EEA21409.1 - 0.0043 17.6 0.0 1.3 9.7 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA21409.1 - 0.029 13.7 0.0 3.3 6.9 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Glu_dehyd_C PF16912.5 EEA21409.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Semialdhyde_dh PF01118.24 EEA21409.1 - 0.13 12.7 0.0 0.8 10.2 0.0 2.3 3 0 0 3 3 2 0 Semialdehyde dehydrogenase, NAD binding domain DUF2721 PF11026.8 EEA21410.1 - 1.5 8.7 9.1 1.8 8.4 3.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Abhydrolase_6 PF12697.7 EEA21411.1 - 4.8e-12 47.0 1.9 7.6e-12 46.3 1.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA21411.1 - 3.5e-08 33.0 0.1 4.8e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA21411.1 - 8.2e-06 25.6 0.1 1.1e-05 25.3 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EEA21411.1 - 0.011 15.6 0.9 0.024 14.5 0.7 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 EEA21411.1 - 0.17 10.5 0.0 0.31 9.6 0.0 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Mito_carr PF00153.27 EEA21412.1 - 2.2e-70 232.7 0.1 2.6e-24 84.9 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EEA21412.1 - 7.1e-16 58.4 2.4 4e-08 33.6 0.2 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EEA21412.1 - 1.8e-14 52.4 1.4 4e-06 26.3 0.1 5.3 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 EEA21412.1 - 1.8e-13 49.0 5.6 1.1e-05 24.6 0.1 5.4 6 0 0 6 6 6 2 EF hand EF-hand_5 PF13202.6 EEA21412.1 - 1.2e-06 27.7 2.1 0.0033 16.9 0.1 3.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EEA21412.1 - 1.5e-06 28.0 5.6 0.34 10.8 0.0 5.4 5 2 1 6 6 6 3 EF-hand domain pair EF-hand_9 PF14658.6 EEA21412.1 - 0.092 13.1 0.0 1.5 9.2 0.0 2.9 2 1 0 2 2 2 0 EF-hand domain OGG_N PF07934.12 EEA21413.1 - 6.2e-37 126.4 0.1 1e-36 125.7 0.1 1.3 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EEA21413.1 - 1.6e-16 60.7 0.0 2.6e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EEA21413.1 - 0.0054 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif RRM_1 PF00076.22 EEA21414.1 - 6.1e-26 90.1 0.0 3.1e-10 39.7 0.0 3.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA21414.1 - 7.1e-05 22.6 0.0 0.42 10.5 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_1 PF00076.22 EEA21415.1 - 6.3e-26 90.0 0.0 3.1e-10 39.7 0.0 3.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA21415.1 - 6.7e-05 22.7 0.0 0.43 10.5 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif 7tm_2 PF00002.24 EEA21416.1 - 0.00012 21.5 9.7 0.00012 21.5 9.7 1.9 1 1 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EEA21416.1 - 1.1 8.3 12.1 0.64 9.1 8.3 2.0 1 1 1 2 2 2 0 Slime mold cyclic AMP receptor Sugar_tr PF00083.24 EEA21417.1 - 1.5e-77 261.4 25.7 1.9e-77 261.1 25.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA21417.1 - 1.1e-12 47.6 68.0 1.3e-11 44.1 36.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily DDDD PF10161.9 EEA21417.1 - 0.11 12.2 1.5 7.2 6.5 0.0 2.7 2 0 0 2 2 2 0 Putative mitochondrial precursor protein DUF2456 PF10445.9 EEA21417.1 - 1.9 8.6 11.5 0.83 9.8 0.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2456) FAD_binding_3 PF01494.19 EEA21418.1 - 1.1e-20 74.2 0.0 4.5e-20 72.2 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA21418.1 - 2.5e-08 33.5 0.0 0.0012 18.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA21418.1 - 3.7e-07 29.6 0.3 6e-07 28.9 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EEA21418.1 - 8.1e-06 24.8 0.2 0.00064 18.5 0.3 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EEA21418.1 - 1.3e-05 25.3 0.3 3.1e-05 24.1 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EEA21418.1 - 0.002 17.3 0.3 0.0045 16.1 0.3 1.6 1 1 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EEA21418.1 - 0.003 18.1 0.4 0.14 12.7 0.6 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA21418.1 - 0.0099 15.5 0.1 0.074 12.6 0.3 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA21418.1 - 0.012 14.9 0.4 0.019 14.2 0.4 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA21418.1 - 0.025 13.8 0.1 0.045 13.0 0.1 1.3 1 0 0 1 1 1 0 Thi4 family DUF1344 PF07076.11 EEA21418.1 - 0.1 12.5 0.0 0.63 10.0 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1344) Amino_oxidase PF01593.24 EEA21418.1 - 0.18 11.1 0.4 2.5 7.3 0.0 2.6 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 EEA21418.1 - 0.21 10.8 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EEA21418.1 - 0.25 10.6 0.2 0.4 10.0 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Fungal_trans PF04082.18 EEA21419.1 - 2.2e-32 112.2 2.0 2.4e-32 112.0 0.0 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21419.1 - 0.00015 21.8 10.3 0.00037 20.5 10.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S13_N PF08069.12 EEA21420.1 - 1.9e-29 101.5 0.1 3.1e-29 100.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EEA21420.1 - 2.6e-14 53.2 0.1 3.8e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 EEA21420.1 - 0.017 15.0 0.1 0.042 13.8 0.0 1.6 2 0 0 2 2 2 0 'Paired box' domain VRR_NUC PF08774.11 EEA21421.1 - 1.3e-24 86.4 0.1 4.6e-24 84.6 0.0 2.0 2 0 0 2 2 2 1 VRR-NUC domain Rho_N PF07498.12 EEA21421.1 - 0.16 11.9 1.4 0.38 10.7 1.4 1.7 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain Dpy-30 PF05186.13 EEA21422.1 - 1.1e-15 57.1 0.2 1.4e-15 56.7 0.2 1.2 1 0 0 1 1 1 1 Dpy-30 motif RRM_1 PF00076.22 EEA21423.1 - 1.7e-19 69.4 0.0 2.5e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA21423.1 - 0.0043 16.6 0.0 0.0063 16.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EPL1 PF10513.9 EEA21424.1 - 1.4e-32 113.2 0.0 2.9e-32 112.2 0.0 1.6 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-HC5HC2H_2 PF13832.6 EEA21424.1 - 1.6e-31 108.7 7.9 1.6e-31 108.7 7.9 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EEA21424.1 - 2.8e-26 91.6 5.4 2.8e-26 91.6 5.4 2.8 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EEA21424.1 - 1.7e-14 53.1 9.4 7.7e-14 51.0 3.4 2.6 2 0 0 2 2 2 2 PHD-finger PHD PF00628.29 EEA21424.1 - 4e-10 39.4 20.3 8.8e-09 35.1 10.0 2.6 2 0 0 2 2 2 2 PHD-finger zf-RING-like PF08746.11 EEA21424.1 - 0.013 15.7 3.5 0.013 15.7 3.5 2.6 2 0 0 2 2 2 0 RING-like domain zf-PHD-like PF15446.6 EEA21424.1 - 0.091 12.4 8.4 0.016 14.8 2.2 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Myb_DNA-bind_6 PF13921.6 EEA21425.1 - 4.3e-07 30.1 3.5 6.6e-07 29.5 0.5 2.3 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA21425.1 - 0.006 16.7 1.9 0.011 15.9 0.1 2.3 1 1 1 2 2 2 1 Myb-like DNA-binding domain APOC4 PF15119.6 EEA21425.1 - 0.051 13.8 0.7 0.24 11.7 0.1 2.2 1 1 1 2 2 2 0 Apolipoprotein C4 MADF_DNA_bdg PF10545.9 EEA21425.1 - 0.27 11.6 5.0 10 6.6 1.1 2.7 1 1 2 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Peptidase_M22 PF00814.25 EEA21426.1 - 1.3e-47 162.8 0.0 6.2e-46 157.3 0.0 2.7 1 1 0 1 1 1 1 Glycoprotease family FGGY_C PF02782.16 EEA21426.1 - 0.017 14.9 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain YycC PF14174.6 EEA21426.1 - 0.058 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 YycC-like protein HET PF06985.11 EEA21427.1 - 8.8e-11 42.3 0.7 7.2e-08 32.9 0.0 2.7 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) SF3b1 PF08920.10 EEA21431.1 - 1.9e-28 99.3 11.4 1e-27 97.0 1.0 3.3 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 EEA21431.1 - 5.8e-12 45.8 8.8 0.2 12.0 0.1 8.7 5 2 5 10 10 10 4 HEAT repeats HEAT_EZ PF13513.6 EEA21431.1 - 6.3e-11 42.5 0.5 0.041 14.4 0.0 6.9 6 0 0 6 6 6 2 HEAT-like repeat HEAT PF02985.22 EEA21431.1 - 5.1e-10 38.7 10.0 0.088 13.1 0.3 9.0 9 0 0 9 9 9 3 HEAT repeat Cnd1 PF12717.7 EEA21431.1 - 3.1e-08 33.8 1.2 0.13 12.3 0.0 6.3 5 2 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EEA21431.1 - 1.3e-05 24.0 0.9 0.022 13.3 0.1 3.4 3 1 0 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 EEA21431.1 - 5.7e-05 23.6 0.9 6.4 7.5 0.0 5.4 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 EEA21431.1 - 0.00032 20.4 0.2 1.2 8.8 0.0 4.2 5 0 0 5 5 5 2 NUC173 domain UNC45-central PF11701.8 EEA21431.1 - 0.0008 19.4 0.0 0.0036 17.3 0.0 2.0 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central UME PF08064.13 EEA21431.1 - 0.0026 17.6 1.2 8.1 6.4 0.0 5.0 7 0 0 7 7 7 1 UME (NUC010) domain CLASP_N PF12348.8 EEA21431.1 - 0.0029 17.2 0.2 0.93 9.0 0.0 3.4 3 0 0 3 3 3 1 CLASP N terminal DUF3385 PF11865.8 EEA21431.1 - 0.0043 17.0 4.7 0.22 11.4 0.1 5.0 4 1 1 6 6 6 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 EEA21431.1 - 0.049 12.7 0.0 2 7.4 0.0 3.2 3 1 0 3 3 3 0 RNAPII transcription regulator C-terminal DRIM PF07539.12 EEA21431.1 - 0.093 11.0 1.6 7.3 4.8 0.0 3.7 2 1 2 4 4 4 0 Down-regulated in metastasis zf-H2C2_2 PF13465.6 EEA21432.1 - 1.9e-10 40.7 14.7 2.3e-05 24.6 0.4 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EEA21432.1 - 4.8e-10 39.3 11.5 2.2e-05 24.7 4.5 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA21432.1 - 7.6e-07 29.4 10.7 0.0013 19.4 3.2 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EEA21432.1 - 5.7e-06 26.5 1.3 1.8e-05 25.0 1.3 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EEA21432.1 - 0.00012 22.0 2.4 0.00012 22.0 2.4 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA21432.1 - 0.00073 19.8 1.8 0.00073 19.8 1.8 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 EEA21432.1 - 0.089 12.7 4.2 2.9 7.9 0.4 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 EEA21432.1 - 0.12 12.7 2.9 0.11 12.9 1.3 1.7 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Actin_micro PF17003.5 EEA21432.1 - 0.26 10.4 0.0 0.35 10.0 0.0 1.1 1 0 0 1 1 1 0 Putative actin-like family zf-C2H2_11 PF16622.5 EEA21432.1 - 0.34 10.7 7.2 6.6 6.6 0.8 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type Phage_holin_4_2 PF04020.13 EEA21434.1 - 0.031 14.9 1.2 0.031 14.9 1.2 2.4 2 1 0 2 2 2 0 Mycobacterial 4 TMS phage holin, superfamily IV CT_A_B PF02626.15 EEA21435.1 - 4.1e-78 262.6 0.0 7.7e-78 261.8 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 EEA21435.1 - 1e-55 188.5 0.0 2.4e-55 187.3 0.0 1.6 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EEA21435.1 - 1.5e-39 135.0 0.2 7.1e-39 132.8 0.1 2.2 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EEA21435.1 - 1.8e-29 102.0 0.0 3.6e-29 101.0 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain CT_C_D PF02682.16 EEA21435.1 - 2.1e-20 73.3 0.0 4.3e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_lipoyl PF00364.22 EEA21435.1 - 3.9e-10 39.4 1.3 1.3e-09 37.7 1.3 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EEA21435.1 - 4.8e-09 36.0 0.0 9.7e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_5 PF13549.6 EEA21435.1 - 0.0048 16.4 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 EEA21435.1 - 0.013 15.1 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EEA21435.1 - 0.028 14.2 1.6 1.9 8.4 0.1 3.3 2 1 1 3 3 3 0 Biotin-lipoyl like SSF PF00474.17 EEA21436.1 - 1.7e-14 53.5 30.3 2.8e-14 52.8 30.3 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family LamB_YcsF PF03746.16 EEA21437.1 - 1.2e-85 287.0 0.1 1.4e-85 286.8 0.1 1.0 1 0 0 1 1 1 1 LamB/YcsF family Amino_oxidase PF01593.24 EEA21438.1 - 2.3e-58 198.6 0.0 2.7e-58 198.4 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EEA21438.1 - 8.9e-14 51.5 0.2 2.3e-13 50.1 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Ribonuc_L-PSP PF01042.21 EEA21438.1 - 2.8e-13 49.9 0.0 6e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Endoribonuclease L-PSP FAD_binding_2 PF00890.24 EEA21438.1 - 1.1e-08 34.6 1.2 1.7e-08 34.0 1.2 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EEA21438.1 - 3.5e-08 33.2 0.2 4.8e-08 32.8 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EEA21438.1 - 9.6e-07 28.7 0.1 1.8e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA21438.1 - 4.8e-06 26.0 0.1 8.4e-06 25.2 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA21438.1 - 5.1e-06 26.0 0.2 8.1e-06 25.3 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EEA21438.1 - 1.7e-05 24.2 0.1 3.4e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EEA21438.1 - 0.0001 21.5 0.6 0.00024 20.3 0.6 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 EEA21438.1 - 0.00011 21.0 0.2 0.00023 20.0 0.2 1.5 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 EEA21438.1 - 0.0004 19.7 1.9 0.00042 19.7 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA21438.1 - 0.001 18.2 0.4 0.0017 17.5 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EEA21438.1 - 0.001 19.6 0.1 0.0025 18.4 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF1999 PF09390.10 EEA21438.1 - 0.019 14.7 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1999) AlaDh_PNT_C PF01262.21 EEA21438.1 - 0.026 13.8 0.3 0.061 12.6 0.3 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EEA21438.1 - 0.46 10.5 2.1 1.5 8.8 0.2 2.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding Aldedh PF00171.22 EEA21439.1 - 3.1e-163 543.6 0.0 3.8e-163 543.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA21439.1 - 0.029 13.8 0.0 0.84 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Fungal_trans PF04082.18 EEA21440.1 - 6.2e-19 68.1 0.3 4.2e-18 65.3 0.0 2.4 2 1 1 3 3 3 1 Fungal specific transcription factor domain SAP PF02037.27 EEA21441.1 - 1.2e-13 50.4 0.6 1.2e-13 50.4 0.6 1.8 2 0 0 2 2 2 1 SAP domain Tho1_MOS11_C PF18592.1 EEA21441.1 - 6.5e-06 25.9 0.4 6.5e-06 25.9 0.4 2.1 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain Methyltransf_11 PF08241.12 EEA21442.1 - 0.00098 19.7 0.0 0.0027 18.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA21442.1 - 0.035 14.8 0.0 0.11 13.2 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain SSrecog PF03531.14 EEA21443.1 - 2.2e-31 107.6 0.1 3e-30 103.9 0.0 3.0 4 0 0 4 4 4 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 EEA21443.1 - 6.8e-31 106.6 0.2 2e-29 101.8 0.0 2.9 3 0 0 3 3 3 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 EEA21443.1 - 1.9e-27 95.5 0.0 5.8e-26 90.7 0.0 2.9 3 0 0 3 3 3 1 Histone chaperone Rttp106-like PH_TFIIH PF08567.11 EEA21443.1 - 0.032 14.6 0.0 2.5 8.5 0.0 3.3 4 0 0 4 4 4 0 TFIIH p62 subunit, N-terminal domain CDC45 PF02724.14 EEA21443.1 - 8.8 4.5 12.8 15 3.7 12.8 1.4 1 0 0 1 1 1 0 CDC45-like protein Rax2 PF12768.7 EEA21444.1 - 2.9e-71 239.3 1.7 3.5e-70 235.8 0.0 3.4 4 0 0 4 4 4 1 Cortical protein marker for cell polarity Kelch_4 PF13418.6 EEA21444.1 - 0.19 11.8 3.0 10 6.3 0.0 4.5 4 0 0 4 4 4 0 Galactose oxidase, central domain Fungal_trans_2 PF11951.8 EEA21445.1 - 2.3e-11 43.2 0.0 4.7e-11 42.1 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Pyr_redox_3 PF13738.6 EEA21446.1 - 9.2e-09 35.0 0.0 4.7e-07 29.4 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EEA21446.1 - 1.7e-08 33.4 0.1 3.5e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EEA21446.1 - 2.2e-08 33.7 0.0 2.8e-05 23.5 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA21446.1 - 3.3e-07 30.4 0.0 7.3e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EEA21446.1 - 1.1e-06 28.1 0.3 5.7e-05 22.4 0.1 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EEA21446.1 - 1.5e-05 24.7 0.0 0.07 12.7 0.1 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EEA21446.1 - 0.0018 17.6 0.0 0.0085 15.4 0.0 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 EEA21446.1 - 0.01 15.9 0.2 3.2 7.7 0.0 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EEA21446.1 - 0.025 13.7 0.1 0.72 8.8 0.0 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EEA21446.1 - 0.044 13.0 0.0 13 4.9 0.0 2.9 3 0 0 3 3 3 0 FAD binding domain MMS1_N PF10433.9 EEA21447.1 - 1.2e-131 439.7 0.1 3.2e-131 438.3 0.0 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EEA21447.1 - 3.4e-70 236.9 0.0 5.6e-67 226.3 0.0 3.2 3 0 0 3 3 3 2 CPSF A subunit region PQQ_2 PF13360.6 EEA21447.1 - 0.03 13.9 0.0 0.13 11.8 0.0 2.0 1 1 0 1 1 1 0 PQQ-like domain NAD_binding_2 PF03446.15 EEA21448.1 - 1.4e-31 109.8 0.0 2e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA21448.1 - 2.1e-30 105.5 0.0 3.7e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EEA21448.1 - 0.0044 17.6 0.0 0.0089 16.6 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EEA21448.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MOR2-PAG1_N PF14222.6 EEA21449.1 - 3.4e-214 712.9 0.0 7.5e-214 711.7 0.0 1.6 2 0 0 2 2 2 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EEA21449.1 - 1e-92 310.6 0.1 1e-92 310.6 0.1 2.7 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EEA21449.1 - 2.9e-30 104.7 16.3 1.8e-12 45.8 0.5 3.8 2 1 1 3 3 3 3 Cell morphogenesis central region Inhibitor_I9 PF05922.16 EEA21449.1 - 0.36 11.5 2.1 1.2 9.8 2.1 1.9 1 0 0 1 1 1 0 Peptidase inhibitor I9 CBM_1 PF00734.18 EEA21450.1 - 4.6e-12 45.7 14.4 4.6e-12 45.7 14.4 3.0 2 0 0 2 2 2 1 Fungal cellulose binding domain DPBB_1 PF03330.18 EEA21450.1 - 3e-08 33.8 0.7 8.5e-08 32.4 0.7 1.8 1 0 0 1 1 1 1 Lytic transglycolase Pro_CA PF00484.19 EEA21452.1 - 5.2e-27 95.1 0.3 7e-27 94.6 0.3 1.1 1 0 0 1 1 1 1 Carbonic anhydrase FAD_binding_1 PF00667.20 EEA21453.1 - 2.2e-65 220.3 0.0 3.3e-65 219.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EEA21453.1 - 1.6e-34 119.2 1.0 3e-34 118.3 1.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EEA21453.1 - 7.4e-21 74.8 0.0 6.5e-20 71.8 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain RRM_1 PF00076.22 EEA21454.1 - 1.9e-23 82.1 0.0 3.3e-12 46.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DnaJ PF00226.31 EEA21455.1 - 2.6e-13 49.9 2.8 3.9e-13 49.3 0.3 2.6 3 0 0 3 3 3 1 DnaJ domain DEAD PF00270.29 EEA21456.1 - 4.8e-48 163.2 0.2 1.2e-47 162.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA21456.1 - 6.7e-24 84.4 0.0 3e-23 82.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA21456.1 - 1.6e-21 76.3 0.1 5.2e-21 74.6 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EEA21456.1 - 1.9e-07 31.3 0.2 6e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Dsh_C PF12316.8 EEA21456.1 - 1.9 8.9 4.2 5.3 7.4 4.2 1.7 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal AA_permease PF00324.21 EEA21457.1 - 3.9e-130 434.7 41.4 4.4e-130 434.5 41.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA21457.1 - 2.3e-42 145.4 47.8 2.8e-42 145.0 47.8 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3671 PF12420.8 EEA21457.1 - 5.2 7.2 5.9 12 6.1 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function Zn_clus PF00172.18 EEA21458.1 - 0.00018 21.6 10.6 0.00027 21.0 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF202 PF02656.15 EEA21459.1 - 1.1e-14 54.6 1.1 1.1e-14 54.6 1.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) TM140 PF14985.6 EEA21459.1 - 0.078 12.5 1.5 0.12 11.9 1.5 1.3 1 0 0 1 1 1 0 TM140 protein family MatE PF01554.18 EEA21460.1 - 4.9e-60 201.8 36.2 2.3e-35 121.6 13.4 2.6 3 0 0 3 3 3 2 MatE RPA_C PF08784.11 EEA21461.1 - 1.1e-20 74.2 0.0 2.4e-20 73.1 0.0 1.6 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EEA21461.1 - 2.9e-06 27.2 0.4 4.5e-06 26.5 0.4 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Chorion_3 PF05387.11 EEA21461.1 - 0.19 11.4 4.6 1.8 8.1 0.3 2.2 2 0 0 2 2 2 0 Chorion family 3 DEAD PF00270.29 EEA21462.1 - 6.1e-47 159.6 0.0 1.7e-46 158.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA21462.1 - 2.7e-23 82.4 0.1 7.8e-23 80.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EEA21462.1 - 3.4e-21 75.2 1.3 3.4e-21 75.2 1.3 3.1 3 0 0 3 3 3 1 DBP10CT (NUC160) domain SLS PF14611.6 EEA21462.1 - 0.063 13.1 0.0 4.6 7.0 0.0 3.3 2 2 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator NUDIX PF00293.28 EEA21463.1 - 2.1e-27 95.7 0.0 3.1e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain zf-C2H2 PF00096.26 EEA21464.1 - 6.2e-10 39.0 22.9 0.0028 18.0 3.9 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA21464.1 - 9e-10 38.5 18.3 6.1e-05 23.3 0.3 3.7 4 0 0 4 4 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA21464.1 - 2.4e-09 37.2 17.4 0.017 15.9 2.7 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EEA21464.1 - 2.8e-06 27.5 8.3 0.0082 16.5 0.2 3.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EEA21464.1 - 2.3e-05 24.3 8.8 0.4 10.7 0.3 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA21464.1 - 3.1e-05 24.1 6.8 0.52 10.7 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EEA21464.1 - 0.024 14.6 13.7 1.9 8.6 1.9 3.5 1 1 2 3 3 3 0 BED zinc finger Zn-ribbon_8 PF09723.10 EEA21464.1 - 0.03 14.4 10.6 0.33 11.1 0.6 3.0 2 1 0 2 2 2 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 EEA21464.1 - 0.14 12.5 9.5 0.32 11.3 0.5 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Zn-C2H2_12 PF18112.1 EEA21464.1 - 0.24 11.9 2.3 1.8 9.1 0.2 3.2 4 0 0 4 4 2 0 Autophagy receptor zinc finger-C2H2 domain FYVE PF01363.21 EEA21464.1 - 0.71 10.1 11.6 2.4 8.3 10.9 2.2 1 1 0 1 1 1 0 FYVE zinc finger zf-Di19 PF05605.12 EEA21464.1 - 0.74 10.2 7.9 0.64 10.4 3.8 2.3 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 EEA21464.1 - 3 8.6 9.2 4.4 8.0 0.4 2.8 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats Rpr2 PF04032.16 EEA21464.1 - 3.5 8.0 8.3 17 5.8 5.8 2.6 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Elf1 PF05129.13 EEA21464.1 - 4.8 7.3 7.8 24 5.0 0.1 2.9 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zinc-ribbons_6 PF07191.12 EEA21464.1 - 7.6 6.6 6.9 28 4.8 1.3 2.5 1 1 1 2 2 2 0 zinc-ribbons zf-H2C2_2 PF13465.6 EEA21465.1 - 1.4e-10 41.1 17.7 3.9e-05 23.9 0.3 3.8 4 0 0 4 4 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EEA21465.1 - 1.9e-10 40.6 22.9 0.0019 18.6 3.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA21465.1 - 6.7e-10 39.0 17.4 0.011 16.5 2.7 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EEA21465.1 - 2.5e-06 27.7 9.9 0.0054 17.1 0.2 3.9 4 0 0 4 4 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EEA21465.1 - 6.5e-06 26.0 8.9 0.26 11.3 0.3 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA21465.1 - 9.3e-06 25.8 6.8 0.34 11.2 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EEA21465.1 - 0.0059 16.6 13.5 1.2 9.3 1.8 3.5 1 1 2 3 3 3 3 BED zinc finger Zn-ribbon_8 PF09723.10 EEA21465.1 - 0.01 15.9 10.5 0.21 11.7 0.6 3.0 2 1 0 2 2 2 0 Zinc ribbon domain Zn-C2H2_12 PF18112.1 EEA21465.1 - 0.042 14.3 1.4 1.2 9.7 0.2 3.5 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 EEA21465.1 - 0.055 13.8 9.9 0.39 11.1 1.8 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) ADK_lid PF05191.14 EEA21465.1 - 0.37 10.8 5.5 2.9 8.0 0.6 2.8 2 1 1 3 3 3 0 Adenylate kinase, active site lid FYVE PF01363.21 EEA21465.1 - 0.45 10.7 12.0 1.9 8.7 11.4 2.3 1 1 0 1 1 1 0 FYVE zinc finger zf-Di19 PF05605.12 EEA21465.1 - 0.49 10.7 8.5 0.41 11.0 3.9 2.3 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 EEA21465.1 - 0.56 10.9 8.3 2.9 8.6 0.4 2.8 1 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zinc_ribbon_4 PF13717.6 EEA21465.1 - 0.67 9.9 4.1 9.8 6.2 0.0 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Rpr2 PF04032.16 EEA21465.1 - 1.5 9.2 8.3 8.9 6.7 5.6 2.5 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-H2C2_5 PF13909.6 EEA21465.1 - 2.6 7.9 6.1 25 4.8 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zinc-ribbons_6 PF07191.12 EEA21465.1 - 2.9 8.0 6.8 1.1e+02 2.9 3.0 2.5 1 1 1 2 2 2 0 zinc-ribbons Elf1 PF05129.13 EEA21465.1 - 5.5 7.1 8.6 17 5.6 0.2 2.6 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-LYAR PF08790.11 EEA21465.1 - 8.4 6.4 8.2 37 4.3 0.1 3.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DZR PF12773.7 EEA21465.1 - 9.6 6.3 8.9 2.8e+02 1.6 8.8 2.7 1 1 1 2 2 2 0 Double zinc ribbon Pkinase PF00069.25 EEA21466.1 - 1.1e-24 87.2 0.0 1.8e-24 86.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EEA21466.1 - 1.1e-12 47.1 5.1 0.0077 16.4 0.1 7.0 6 0 0 6 6 6 3 HEAT repeat WD40 PF00400.32 EEA21466.1 - 4.5e-08 33.6 7.5 1.5e-05 25.7 0.1 4.7 4 0 0 4 4 3 2 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 EEA21466.1 - 1.4e-06 27.9 0.0 3.5e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Cnd1 PF12717.7 EEA21466.1 - 8.9e-05 22.6 0.3 0.027 14.5 0.0 3.3 2 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA21466.1 - 0.00013 22.3 0.0 3.7 8.0 0.0 4.0 2 2 1 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 EEA21466.1 - 0.00021 21.7 1.0 0.2 12.2 0.2 4.1 4 0 0 4 4 4 1 HEAT-like repeat Ge1_WD40 PF16529.5 EEA21466.1 - 0.01 14.8 0.1 0.084 11.8 0.0 2.3 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Tti2 PF10521.9 EEA21466.1 - 0.017 14.7 0.0 0.044 13.3 0.0 1.7 1 0 0 1 1 1 0 Tti2 family RTP1_C1 PF10363.9 EEA21466.1 - 0.05 13.8 0.3 16 5.7 0.0 2.7 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 EEA21466.1 - 0.051 13.9 2.1 8.9 6.7 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion MAP65_ASE1 PF03999.12 EEA21466.1 - 5.8 5.5 9.2 9.5 4.8 9.2 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DENN PF02141.21 EEA21467.1 - 3.5e-40 137.9 0.0 7.3e-40 136.9 0.0 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EEA21467.1 - 3.3e-06 27.7 0.0 1.1e-05 26.1 0.0 2.0 1 0 0 1 1 1 1 uDENN domain Elongin_A PF06881.11 EEA21467.1 - 0.0027 18.2 3.3 0.0027 18.2 3.3 2.3 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A BRE1 PF08647.11 EEA21467.1 - 0.28 11.3 15.3 0.38 10.9 4.0 2.7 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3450 PF11932.8 EEA21467.1 - 0.57 9.4 13.8 0.4 9.9 1.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 EEA21467.1 - 2 8.4 18.4 0.13 12.3 4.8 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 adh_short_C2 PF13561.6 EEA21468.1 - 6.4e-54 183.0 0.7 7.5e-54 182.7 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA21468.1 - 4.2e-42 143.8 0.1 5.7e-42 143.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA21468.1 - 1.6e-07 31.4 0.0 4.3e-07 30.0 0.0 1.6 1 1 0 1 1 1 1 KR domain RabGAP-TBC PF00566.18 EEA21469.1 - 2.1e-43 148.5 0.0 1.7e-42 145.5 0.0 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Porphobil_deamC PF03900.15 EEA21469.1 - 0.16 12.4 0.0 0.44 11.0 0.0 1.7 1 0 0 1 1 1 0 Porphobilinogen deaminase, C-terminal domain Synaptobrevin PF00957.21 EEA21470.1 - 9.3e-32 108.7 0.0 1.2e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EEA21470.1 - 1e-28 99.2 0.0 1.6e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF4258 PF14076.6 EEA21470.1 - 0.29 11.5 1.8 0.69 10.3 0.2 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4258) Ribosomal_L26 PF16906.5 EEA21471.1 - 7.5e-39 132.1 3.1 1e-38 131.6 3.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EEA21471.1 - 2.1e-07 30.6 1.2 5.2e-07 29.4 1.2 1.7 1 0 0 1 1 1 1 KOW motif DUF1223 PF06764.11 EEA21471.1 - 0.048 13.7 0.1 0.06 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) FOXP-CC PF16159.5 EEA21472.1 - 7.3 7.3 10.6 2.5 8.8 1.0 3.3 2 1 1 3 3 3 0 FOXP coiled-coil domain Ost4 PF10215.9 EEA21473.1 - 3.6e-19 68.3 0.4 4.8e-19 67.9 0.4 1.2 1 0 0 1 1 1 1 Oligosaccaryltransferase Acyl_transf_3 PF01757.22 EEA21473.1 - 0.15 11.0 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Acyltransferase family Fungal_trans PF04082.18 EEA21474.1 - 5.1e-16 58.5 0.0 8.1e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21474.1 - 1e-09 38.4 5.0 1.5e-09 37.8 5.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_MalT PF17874.1 EEA21474.1 - 0.058 12.7 0.2 0.1 12.0 0.2 1.3 1 0 0 1 1 1 0 MalT-like TPR region DUF4357 PF14267.6 EEA21474.1 - 0.073 13.0 0.1 5.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) ApbA PF02558.16 EEA21478.1 - 1.1e-07 31.7 0.0 2.3e-07 30.6 0.0 1.6 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EEA21478.1 - 0.049 12.9 0.1 0.075 12.3 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain AAA-ATPase_like PF09820.9 EEA21478.1 - 0.074 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Predicted AAA-ATPase Enolase_N PF03952.16 EEA21478.1 - 0.11 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Enolase, N-terminal domain Ion_trans PF00520.31 EEA21480.1 - 2.3e-06 27.0 28.3 3.6e-06 26.4 28.3 1.3 1 0 0 1 1 1 1 Ion transport protein CPSase_L_D2 PF02786.17 EEA21481.1 - 2.5e-114 380.0 0.1 3.2e-84 281.7 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EEA21481.1 - 3.5e-48 162.7 0.0 7.1e-48 161.7 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EEA21481.1 - 3.3e-47 160.7 0.0 8.6e-47 159.4 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 EEA21481.1 - 1.1e-45 155.3 0.0 2.3e-45 154.3 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EEA21481.1 - 5e-39 133.4 0.0 1.2e-38 132.2 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EEA21481.1 - 8.7e-31 107.1 0.0 2.2e-30 105.8 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EEA21481.1 - 2e-22 79.2 0.0 7.6e-22 77.3 0.0 2.1 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EEA21481.1 - 1.1e-16 61.0 0.4 1.1e-07 31.7 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EEA21481.1 - 1.1e-15 57.6 0.1 3.1e-07 30.1 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EEA21481.1 - 1.7e-09 37.5 0.0 0.00035 20.3 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EEA21481.1 - 1e-05 25.4 0.5 0.00074 19.3 0.5 2.5 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 EEA21481.1 - 1.5e-05 25.1 0.3 0.094 12.8 0.0 2.9 3 0 0 3 3 3 2 ATP-grasp domain DJ-1_PfpI PF01965.24 EEA21481.1 - 9.6e-05 22.2 0.0 0.096 12.5 0.0 4.3 4 0 0 4 4 4 1 DJ-1/PfpI family RimK PF08443.11 EEA21481.1 - 0.0014 18.3 0.0 0.82 9.2 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.19 EEA21481.1 - 0.0026 17.6 0.3 2.6 7.8 0.0 2.8 3 0 0 3 3 3 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF4393 PF14337.6 EEA21482.1 - 0.51 10.1 10.1 0.1 12.4 2.6 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4393) DUF1840 PF08895.11 EEA21482.1 - 1 9.7 4.9 0.62 10.4 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DUF874 PF05917.11 EEA21482.1 - 2.9 6.8 12.1 0.063 12.3 2.0 2.3 2 0 0 2 2 2 0 Helicobacter pylori protein of unknown function (DUF874) AMP-binding PF00501.28 EEA21483.1 - 6.1e-81 272.2 0.0 7.6e-81 271.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA21483.1 - 1.1e-12 48.7 0.2 3e-12 47.3 0.1 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ABC_tran PF00005.27 EEA21484.1 - 7.9e-24 84.7 0.1 2.8e-10 40.8 0.0 3.8 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EEA21484.1 - 1.2e-08 35.1 1.7 0.0014 18.5 0.1 3.9 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EEA21484.1 - 1e-06 28.9 0.0 0.064 13.5 0.0 2.7 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EEA21484.1 - 0.019 14.7 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ploopntkinase1 PF18748.1 EEA21484.1 - 0.041 13.4 0.0 0.087 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 Myc_N PF01056.18 EEA21484.1 - 0.22 11.4 6.5 0.35 10.7 6.5 1.3 1 0 0 1 1 1 0 Myc amino-terminal region NOA36 PF06524.12 EEA21484.1 - 0.36 10.1 9.2 0.63 9.3 9.2 1.3 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 EEA21484.1 - 2.7 7.7 9.2 8.1 6.2 9.2 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ank_2 PF12796.7 EEA21485.1 - 2.7e-66 220.2 0.5 1.7e-16 60.5 0.1 6.1 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA21485.1 - 3.9e-56 186.4 4.2 3.6e-10 39.9 0.0 9.0 4 2 5 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA21485.1 - 2.3e-51 165.8 0.1 0.00012 22.2 0.0 11.0 11 0 0 11 11 11 10 Ankyrin repeat Ank PF00023.30 EEA21485.1 - 3.8e-46 153.6 0.0 0.00025 21.4 0.0 10.4 10 0 0 10 10 10 10 Ankyrin repeat Ank_4 PF13637.6 EEA21485.1 - 6e-42 141.5 0.2 1.7e-07 31.7 0.0 7.4 5 2 3 8 8 8 7 Ankyrin repeats (many copies) DGF-1_C PF11040.8 EEA21485.1 - 0.027 14.5 0.2 1.2 9.1 0.1 3.4 3 1 1 4 4 4 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus VWA_3_C PF18571.1 EEA21485.1 - 0.031 14.1 15.2 0.79 9.6 0.2 6.9 7 1 1 8 8 8 0 von Willebrand factor type A C-terminal domain F-box_4 PF15966.5 EEA21485.1 - 0.054 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 F-box F-box PF00646.33 EEA21485.1 - 0.064 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EEA21485.1 - 0.072 13.0 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 F-box-like 3HCDH_RFF PF18321.1 EEA21485.1 - 0.12 12.9 0.3 18 5.8 0.0 4.2 5 0 0 5 5 5 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Exo84_C PF16528.5 EEA21486.1 - 3.2e-69 232.9 0.5 3.2e-69 232.9 0.5 2.2 3 0 0 3 3 3 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EEA21486.1 - 3.5e-18 65.5 1.4 3.5e-18 65.5 1.4 2.3 2 0 0 2 2 2 1 Vps51/Vps67 Exonuc_VII_S PF02609.16 EEA21486.1 - 0.11 12.6 0.1 13 5.9 0.0 2.8 2 0 0 2 2 2 0 Exonuclease VII small subunit COG2 PF06148.11 EEA21486.1 - 0.21 11.7 1.4 0.54 10.3 0.3 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HIP1_clath_bdg PF16515.5 EEA21486.1 - 0.29 11.8 8.7 0.82 10.3 5.2 2.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Exonuc_VII_L PF02601.15 EEA21486.1 - 0.31 10.6 5.8 1.9 8.0 1.9 2.4 2 1 0 2 2 2 0 Exonuclease VII, large subunit BST2 PF16716.5 EEA21486.1 - 1 10.0 5.7 6.3 7.5 2.3 2.8 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 HAUS6_N PF14661.6 EEA21486.1 - 2.1 7.9 5.5 1.2 8.7 2.9 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus MAS20 PF02064.15 EEA21487.1 - 1.5e-46 157.7 0.8 1.7e-46 157.5 0.8 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor DUF4199 PF13858.6 EEA21487.1 - 0.052 14.0 0.0 0.072 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) PMC2NT PF08066.12 EEA21487.1 - 0.1 13.3 0.0 0.17 12.6 0.0 1.4 1 0 0 1 1 1 0 PMC2NT (NUC016) domain Sarcoglycan_1 PF04790.13 EEA21488.1 - 0.28 10.5 1.3 3.5 6.9 0.2 2.2 2 0 0 2 2 2 0 Sarcoglycan complex subunit protein Tetraspanin PF00335.20 EEA21488.1 - 3.9 7.1 7.7 7 6.3 6.8 1.8 1 1 0 1 1 1 0 Tetraspanin family ABC2_membrane_2 PF12679.7 EEA21488.1 - 4.4 6.5 9.1 2.2 7.5 7.0 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein FeoB_associated PF12669.7 EEA21488.1 - 4.6 7.7 9.9 0.46 10.9 2.2 3.0 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein MFS_1 PF07690.16 EEA21489.1 - 1.2e-32 113.2 58.9 2.8e-32 112.0 56.7 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA21489.1 - 4e-21 75.1 25.8 6.5e-21 74.4 25.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA21489.1 - 1.2e-15 57.4 6.2 1.2e-15 57.4 6.2 2.4 2 1 1 3 3 3 1 Sugar (and other) transporter DUF3796 PF12676.7 EEA21489.1 - 0.058 13.8 1.3 0.11 12.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3796) DUF3522 PF12036.8 EEA21489.1 - 0.27 11.5 5.2 0.11 12.7 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) PIG-P PF08510.12 EEA21489.1 - 1.3 8.9 5.3 5.3 7.0 5.3 2.0 1 0 0 1 1 1 0 PIG-P OATP PF03137.20 EEA21489.1 - 2.8 6.1 13.2 3 6.0 9.9 2.5 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Transferase PF02458.15 EEA21490.1 - 2.7e-08 32.9 0.0 1.5e-07 30.4 0.0 2.0 2 1 0 2 2 2 1 Transferase family NACHT PF05729.12 EEA21491.1 - 4.7e-11 42.9 0.0 9.3e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain HEAT_2 PF13646.6 EEA21491.1 - 4.2e-10 39.9 0.2 1.9e-09 37.8 0.2 2.2 2 0 0 2 2 1 1 HEAT repeats NLRC4_HD2 PF17776.1 EEA21491.1 - 3.7e-08 34.0 0.0 1.2e-07 32.3 0.0 1.9 1 0 0 1 1 1 1 NLRC4 helical domain HD2 HEAT PF02985.22 EEA21491.1 - 3.5e-07 29.9 0.0 0.055 13.7 0.0 3.3 2 0 0 2 2 2 2 HEAT repeat NB-ARC PF00931.22 EEA21491.1 - 3.1e-06 26.6 0.0 5.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain HEAT_EZ PF13513.6 EEA21491.1 - 0.0011 19.4 0.9 0.012 16.1 0.6 3.0 3 1 0 3 3 2 1 HEAT-like repeat PNP_UDP_1 PF01048.20 EEA21491.1 - 0.0061 15.8 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.6 EEA21491.1 - 0.0063 16.8 0.1 0.022 15.0 0.0 1.9 2 0 0 2 2 1 1 AAA domain HEAT_PBS PF03130.16 EEA21491.1 - 0.016 15.9 0.5 7.8 7.5 0.1 3.3 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat AAA_16 PF13191.6 EEA21491.1 - 0.02 15.3 0.0 0.08 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 EEA21491.1 - 0.022 15.2 0.0 0.068 13.6 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Cohesin_HEAT PF12765.7 EEA21491.1 - 0.047 14.0 0.7 1.8 9.0 0.2 2.8 3 0 0 3 3 2 0 HEAT repeat associated with sister chromatid cohesion AAA_18 PF13238.6 EEA21491.1 - 0.054 14.0 0.0 0.43 11.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EEA21491.1 - 0.064 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.6 EEA21491.1 - 0.16 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DDE_3 PF13358.6 EEA21492.1 - 9.7e-31 106.5 0.0 1.5e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 EEA21492.1 - 1e-07 31.5 0.0 7.2e-07 28.8 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn helix rve PF00665.26 EEA21492.1 - 0.00046 20.4 0.0 0.0012 19.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_1 PF03184.19 EEA21492.1 - 0.00063 19.4 0.0 0.00091 18.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.11 EEA21492.1 - 0.054 12.5 0.1 6.8 5.6 0.0 2.2 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain zf-RVT PF13966.6 EEA21494.1 - 0.0058 17.3 0.3 0.026 15.2 0.1 2.2 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase RNase_H PF00075.24 EEA21494.1 - 0.014 15.6 0.2 0.05 13.8 0.2 2.0 1 1 0 1 1 1 0 RNase H Fungal_trans PF04082.18 EEA21495.1 - 1.5e-14 53.7 0.7 2.8e-14 52.8 0.5 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Response_reg PF00072.24 EEA21496.1 - 7.1e-24 84.1 0.8 1.3e-23 83.3 0.8 1.4 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 EEA21496.1 - 4.7e-10 39.7 0.0 3.2e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EEA21496.1 - 6.5e-09 36.0 0.0 0.0038 17.4 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 EEA21496.1 - 2.7e-05 24.1 0.1 0.0061 16.6 0.0 2.4 2 0 0 2 2 2 2 PAS fold DUF1541 PF07563.11 EEA21496.1 - 0.36 10.8 3.1 9.1 6.2 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) RVT_1 PF00078.27 EEA21497.1 - 1.9e-33 115.8 0.0 3.8e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA21497.1 - 2.4e-22 79.0 0.0 5.3e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EEA21497.1 - 3.8e-05 23.3 0.0 8.7e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EEA21497.1 - 0.00062 19.7 2.3 0.00062 19.7 2.3 2.4 2 0 0 2 2 2 1 Zinc knuckle NUDIX PF00293.28 EEA21498.1 - 8.9e-16 58.1 0.4 1.4e-15 57.5 0.4 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 EEA21498.1 - 0.087 12.8 0.0 0.27 11.2 0.0 1.9 1 1 0 1 1 1 0 NUDIX domain Peptidase_M19 PF01244.21 EEA21499.1 - 3.2e-102 342.0 0.0 3.8e-102 341.7 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Radical_SAM PF04055.21 EEA21500.1 - 4.1e-22 79.3 0.1 1.4e-21 77.6 0.0 2.0 2 1 0 2 2 2 1 Radical SAM superfamily Wyosine_form PF08608.12 EEA21500.1 - 5.8e-22 77.8 0.0 1.2e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.25 EEA21500.1 - 6e-08 33.0 0.0 4.5e-06 26.9 0.0 2.5 2 0 0 2 2 2 1 Flavodoxin adh_short PF00106.25 EEA21501.1 - 5.9e-35 120.5 1.3 7.6e-35 120.1 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21501.1 - 9.5e-35 120.2 0.1 1.2e-34 119.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA21501.1 - 7.5e-06 26.0 0.3 9.9e-06 25.6 0.3 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EEA21501.1 - 0.0089 15.9 1.3 0.013 15.3 1.3 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sulf_coat_C PF12193.8 EEA21502.1 - 0.021 14.8 0.1 0.053 13.6 0.1 1.7 1 0 0 1 1 1 0 Sulfolobus virus coat protein C terminal DUF2070 PF09843.9 EEA21502.1 - 2.8 6.1 7.6 3.4 5.8 7.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4219 PF13961.6 EEA21503.1 - 3.9e-12 45.5 0.1 5.7e-12 45.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) TPR_10 PF13374.6 EEA21505.1 - 1.1e-104 339.8 1.6 2.7e-11 42.9 0.0 10.6 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_12 PF13424.6 EEA21505.1 - 2.3e-99 325.8 11.3 7.7e-14 51.7 0.1 8.8 1 1 9 10 10 10 10 Tetratricopeptide repeat TPR_7 PF13176.6 EEA21505.1 - 1.2e-34 115.8 0.4 0.0077 16.2 0.0 9.6 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EEA21505.1 - 5.8e-23 79.1 4.6 1.4 9.2 0.0 10.4 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.28 EEA21505.1 - 7.6e-21 73.0 10.6 0.91 9.4 0.0 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_19 PF14559.6 EEA21505.1 - 5e-18 65.4 0.0 2.4 8.7 0.0 9.2 4 1 5 9 9 9 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA21505.1 - 2e-14 53.7 12.3 4.3e-08 32.9 1.8 3.8 1 1 2 4 4 4 3 MalT-like TPR region TPR_17 PF13431.6 EEA21505.1 - 3.7e-12 45.7 15.9 0.4 11.2 0.0 9.6 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA21505.1 - 3.2e-09 37.3 1.0 29 5.4 0.0 8.9 8 1 0 9 9 9 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA21505.1 - 4.8e-09 35.7 12.2 19 5.8 0.1 9.9 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_5 PF12688.7 EEA21505.1 - 9.8e-09 35.5 0.1 0.28 11.4 0.0 5.6 1 1 2 5 5 5 1 Tetratrico peptide repeat NB-ARC PF00931.22 EEA21505.1 - 2.7e-08 33.3 0.0 9.1e-08 31.6 0.0 1.9 1 0 0 1 1 1 1 NB-ARC domain NACHT PF05729.12 EEA21505.1 - 6.3e-08 32.7 1.4 2.3e-06 27.6 0.3 3.0 2 1 0 2 2 2 1 NACHT domain PNP_UDP_1 PF01048.20 EEA21505.1 - 1.1e-07 31.3 0.0 5.2e-07 29.1 0.0 2.1 1 1 0 1 1 1 1 Phosphorylase superfamily TPR_3 PF07720.12 EEA21505.1 - 1.4e-07 31.3 0.0 28 4.8 0.0 6.9 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 EEA21505.1 - 9.2e-07 28.9 0.0 6.6 7.7 0.0 7.4 8 0 0 8 8 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA21505.1 - 2.1e-06 27.9 0.3 5.2 7.4 0.0 7.2 2 2 4 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EEA21505.1 - 6.2e-06 26.6 2.7 48 5.1 0.0 8.2 9 0 0 9 9 7 0 Tetratricopeptide repeat DUF4074 PF13293.6 EEA21505.1 - 6.8e-05 23.1 0.9 47 4.4 0.1 7.4 8 0 0 8 8 8 0 Domain of unknown function (DUF4074) AAA_16 PF13191.6 EEA21505.1 - 0.00027 21.3 0.0 0.002 18.5 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA21505.1 - 0.0056 16.9 0.0 0.019 15.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF1897 PF09005.10 EEA21505.1 - 0.0098 15.4 10.7 13 5.4 0.1 7.0 8 0 0 8 8 8 0 Domain of unknown function (DUF1897) Urocanase_N PF17391.2 EEA21505.1 - 0.031 14.0 5.2 62 3.3 0.0 5.9 1 1 5 7 7 7 0 Urocanase N-terminal domain Imm49 PF15575.6 EEA21505.1 - 0.065 13.0 0.3 0.21 11.3 0.3 2.0 1 0 0 1 1 1 0 Immunity protein 49 TPR_6 PF13174.6 EEA21505.1 - 0.09 13.5 14.7 1e+02 3.8 0.0 9.0 10 0 0 10 10 9 0 Tetratricopeptide repeat DUF3574 PF12098.8 EEA21505.1 - 0.13 12.1 1.5 13 5.6 0.0 3.7 2 1 3 5 5 5 0 Protein of unknown function (DUF3574) DUF4919 PF16266.5 EEA21505.1 - 0.23 11.4 1.6 51 3.7 0.0 3.8 2 2 1 4 4 4 0 Domain of unknown function (DUF4919) DUF3157 PF11355.8 EEA21505.1 - 2.1 7.9 9.6 41 3.7 0.1 4.3 3 2 1 5 5 5 0 Protein of unknown function (DUF3157) Smg4_UPF3 PF03467.15 EEA21506.1 - 2.1e-42 145.1 0.0 2.1e-42 145.1 0.0 3.8 2 1 1 3 3 3 1 Smg-4/UPF3 family RRM_1 PF00076.22 EEA21506.1 - 3.2e-09 36.5 0.5 4e-08 32.9 0.1 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos PF00149.28 EEA21507.1 - 5.3e-35 121.8 0.0 4.7e-34 118.7 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EEA21507.1 - 0.099 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Aldedh PF00171.22 EEA21509.1 - 2.3e-183 609.9 0.1 2.6e-183 609.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family GAIN PF16489.5 EEA21509.1 - 0.2 11.1 0.0 0.39 10.1 0.0 1.4 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain Glyco_hydro_72 PF03198.14 EEA21511.1 - 3.2e-120 401.1 0.7 4.4e-120 400.7 0.7 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Mre11_DNA_bind PF04152.14 EEA21512.1 - 2.5e-56 190.6 1.3 6.5e-56 189.3 1.3 1.8 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EEA21512.1 - 2.2e-14 54.5 1.2 4.2e-14 53.5 1.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA21512.1 - 0.003 17.8 0.0 0.032 14.4 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Baculo_gp64 PF03273.13 EEA21512.1 - 0.13 11.0 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family CHIP_TPR_N PF18391.1 EEA21512.1 - 0.66 10.8 6.6 15 6.4 0.2 2.7 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain F-box-like PF12937.7 EEA21513.1 - 1.7e-10 40.6 0.0 3.5e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA21513.1 - 6.9e-09 35.4 0.0 2.7e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 EEA21513.1 - 0.015 15.2 0.0 0.046 13.6 0.0 1.8 1 0 0 1 1 1 0 F-box AA_permease_2 PF13520.6 EEA21514.1 - 2.2e-61 208.0 49.8 2.6e-61 207.7 49.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA21514.1 - 5e-15 55.1 43.2 8.9e-15 54.2 43.1 1.4 1 1 0 1 1 1 1 Amino acid permease DUF2678 PF10856.8 EEA21514.1 - 1.4 8.9 6.1 6 6.8 2.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) PBP PF01161.20 EEA21515.1 - 1.9e-07 31.5 1.2 4.6e-06 27.0 0.1 2.7 2 1 0 2 2 2 1 Phosphatidylethanolamine-binding protein Aa_trans PF01490.18 EEA21516.1 - 3.1e-34 118.4 24.6 4.8e-34 117.8 24.6 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein adh_short PF00106.25 EEA21517.1 - 9.1e-37 126.4 0.1 3.2e-36 124.6 0.1 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21517.1 - 4.5e-36 124.6 0.3 1.7e-28 99.8 0.1 2.9 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA21517.1 - 8.3e-12 45.4 0.1 9.3e-11 42.0 0.1 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA21517.1 - 0.0004 19.9 0.6 0.0038 16.7 0.6 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA21517.1 - 0.006 16.0 0.1 0.069 12.5 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase OMP_b-brl_3 PF14905.6 EEA21517.1 - 0.0075 15.3 0.2 0.011 14.8 0.2 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel family MAPEG PF01124.18 EEA21518.1 - 8.4e-15 54.8 1.4 1.1e-14 54.4 1.4 1.2 1 0 0 1 1 1 1 MAPEG family BTP PF05232.12 EEA21518.1 - 0.091 12.8 0.3 0.091 12.8 0.3 2.2 2 0 0 2 2 2 0 Chlorhexidine efflux transporter Arylsulfotran_2 PF14269.6 EEA21519.1 - 1.1e-37 130.0 0.0 1.7e-37 129.4 0.0 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EEA21519.1 - 6.2e-07 28.6 0.0 2.1e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Arylsulfotransferase (ASST) PQQ_2 PF13360.6 EEA21519.1 - 0.00037 20.2 0.6 0.066 12.8 0.1 3.4 4 1 0 4 4 4 2 PQQ-like domain Arylsulfotran_2 PF14269.6 EEA21520.1 - 2.1e-34 119.3 0.0 2.9e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EEA21520.1 - 2.9e-05 23.2 0.1 9.9e-05 21.4 0.0 1.8 2 0 0 2 2 2 1 Arylsulfotransferase (ASST) PQQ_2 PF13360.6 EEA21520.1 - 0.006 16.2 0.6 0.049 13.2 0.1 2.7 3 1 0 3 3 3 1 PQQ-like domain DUF659 PF04937.15 EEA21521.1 - 6.6e-10 39.0 0.5 1.4e-09 38.0 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Fungal_trans PF04082.18 EEA21521.1 - 2.5e-06 26.7 0.0 7.5e-06 25.2 0.0 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dimer_Tnp_hAT PF05699.14 EEA21521.1 - 0.00012 21.7 0.3 0.0013 18.4 0.1 2.5 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Presenilin PF01080.17 EEA21521.1 - 5.1 5.8 10.7 44 2.7 0.0 2.5 2 0 0 2 2 2 0 Presenilin Glyco_transf_41 PF13844.6 EEA21522.1 - 1e-104 350.6 1.1 5.6e-51 173.4 0.1 4.1 1 1 1 2 2 2 2 Glycosyl transferase family 41 TPR_1 PF00515.28 EEA21522.1 - 5.6e-18 63.9 10.6 1.2e-05 24.9 0.1 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 EEA21522.1 - 2.9e-15 55.1 13.0 0.006 16.6 0.1 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EEA21522.1 - 8.7e-14 50.9 14.6 1.9e-05 24.2 0.2 6.4 3 2 3 6 6 6 4 TPR repeat TPR_8 PF13181.6 EEA21522.1 - 4.3e-11 42.1 5.4 0.088 13.1 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA21522.1 - 5.2e-10 39.0 5.7 0.02 15.2 0.0 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EEA21522.1 - 7e-07 29.7 13.5 0.0035 17.8 0.7 4.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA21522.1 - 7.2e-07 29.5 11.8 0.058 14.2 0.0 5.7 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA21522.1 - 2.5e-06 27.7 9.3 0.039 14.2 0.4 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 EEA21522.1 - 1.9e-05 24.3 15.3 0.64 10.0 0.2 5.7 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 EEA21522.1 - 2.6e-05 24.8 15.6 0.23 12.2 1.4 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA21522.1 - 0.0022 17.9 9.1 0.55 10.4 0.1 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EEA21522.1 - 0.088 13.0 7.2 0.37 11.0 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA21522.1 - 0.36 11.1 2.5 0.82 9.9 0.4 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Glyco_hydro_47 PF01532.20 EEA21523.1 - 6.1e-178 592.4 0.0 7e-178 592.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 BTB PF00651.31 EEA21524.1 - 9.6e-07 29.0 0.1 1.8e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain ExbD PF02472.16 EEA21524.1 - 0.21 11.8 1.4 0.7 10.1 0.0 2.2 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR GMC_oxred_C PF05199.13 EEA21525.1 - 1e-27 97.4 0.0 1.3e-27 97.0 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Ribosomal_L11_N PF03946.14 EEA21526.1 - 3.5e-24 84.4 0.2 5.6e-24 83.8 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EEA21526.1 - 5e-14 52.6 0.1 8.8e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11 PF00298.19 EEA21527.1 - 2.9e-14 53.3 0.1 4.3e-14 52.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EEA21527.1 - 0.0012 18.6 0.1 0.0023 17.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain DDE_1 PF03184.19 EEA21528.1 - 3.9e-31 108.0 0.0 6.4e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA21528.1 - 5.3e-12 45.6 0.3 1.4e-11 44.2 0.1 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA21528.1 - 2.5e-06 27.1 0.0 4.7e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain UPF0175 PF03683.13 EEA21528.1 - 0.0036 17.0 0.0 0.012 15.3 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0175) DDE_3 PF13358.6 EEA21528.1 - 0.0046 16.7 0.0 0.017 14.9 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_8 PF02954.19 EEA21528.1 - 0.026 14.3 0.0 0.06 13.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_17 PF12728.7 EEA21528.1 - 0.054 13.7 1.0 2 8.6 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain Sec23_trunk PF04811.15 EEA21529.1 - 1.6e-80 270.2 0.0 2.4e-80 269.6 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EEA21529.1 - 4.4e-29 101.1 0.0 9.8e-29 100.0 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EEA21529.1 - 3.6e-24 84.5 0.0 8.2e-24 83.4 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EEA21529.1 - 2.5e-14 53.0 4.1 4.5e-14 52.2 4.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EEA21529.1 - 8e-12 44.9 0.0 3.8e-11 42.7 0.0 2.1 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EEA21529.1 - 0.019 14.3 1.3 0.029 13.8 0.3 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DNA_primase_lrg PF04104.14 EEA21530.1 - 6.5e-87 291.3 0.0 9.8e-87 290.7 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit ADK PF00406.22 EEA21531.1 - 3.2e-36 124.7 0.0 5.5e-19 68.7 0.0 2.1 1 1 1 2 2 2 2 Adenylate kinase ADK_lid PF05191.14 EEA21531.1 - 1.8e-16 59.8 0.1 1.4e-15 56.9 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EEA21531.1 - 4.4e-14 53.1 0.0 1.2e-11 45.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA21531.1 - 6.5e-06 26.7 0.0 2.3e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA21531.1 - 0.004 17.3 0.2 0.045 13.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EEA21531.1 - 0.023 14.9 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EEA21531.1 - 0.066 12.2 0.1 0.094 11.7 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EEA21531.1 - 0.094 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EEA21531.1 - 0.1 12.6 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SNase PF00565.17 EEA21532.1 - 1e-21 77.4 0.0 1.7e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Mito_carr PF00153.27 EEA21533.1 - 1.1e-55 185.5 0.3 5.8e-19 67.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_11 PF00457.17 EEA21534.1 - 1.9e-65 219.8 14.8 1.9e-65 219.8 14.8 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 11 CBM_1 PF00734.18 EEA21534.1 - 2.2e-13 49.9 12.6 2.2e-13 49.9 12.6 2.2 2 0 0 2 2 2 1 Fungal cellulose binding domain Cutinase PF01083.22 EEA21535.1 - 1.5e-51 174.8 7.5 1.9e-51 174.6 7.5 1.1 1 0 0 1 1 1 1 Cutinase CBM_1 PF00734.18 EEA21535.1 - 3.2e-12 46.2 14.8 3.2e-12 46.2 14.8 4.2 5 1 0 5 5 5 1 Fungal cellulose binding domain PE-PPE PF08237.11 EEA21535.1 - 5.6e-05 22.8 0.8 7.7e-05 22.3 0.8 1.2 1 0 0 1 1 1 1 PE-PPE domain Abhydrolase_1 PF00561.20 EEA21535.1 - 0.054 13.1 0.1 0.083 12.5 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA21535.1 - 0.18 11.1 0.1 0.27 10.5 0.1 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Toxin_7 PF05980.12 EEA21535.1 - 4.6 7.6 10.8 2 8.7 0.5 2.9 2 1 1 3 3 3 0 Toxin 7 Peptidase_C2 PF00648.21 EEA21536.1 - 6.7e-30 104.1 0.0 1e-29 103.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EEA21536.1 - 1.1e-06 28.9 0.0 1.6e-05 25.2 0.0 2.6 2 1 0 2 2 2 1 Calpain large subunit, domain III MIT PF04212.18 EEA21536.1 - 0.0016 18.5 1.1 0.0027 17.7 1.1 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Vta1 PF04652.16 EEA21537.1 - 7.4e-58 194.6 1.8 1e-57 194.2 0.4 1.8 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EEA21537.1 - 5e-18 64.5 0.2 1.3e-17 63.2 0.2 1.8 1 0 0 1 1 1 1 Vta1 C-terminal domain Vta1 PF04652.16 EEA21538.1 - 2.4e-34 118.4 2.8 2.5e-34 118.3 0.8 1.9 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EEA21538.1 - 3.8e-18 64.9 0.2 1e-17 63.5 0.2 1.8 1 0 0 1 1 1 1 Vta1 C-terminal domain Epimerase PF01370.21 EEA21539.1 - 5.8e-18 65.2 0.0 1e-17 64.4 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EEA21539.1 - 2.9e-12 46.3 0.0 4.1e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EEA21539.1 - 2.3e-06 26.9 0.0 6.7e-05 22.0 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA21539.1 - 0.00044 19.7 0.0 0.00086 18.8 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Ldh_1_N PF00056.23 EEA21539.1 - 0.018 15.1 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain KR PF08659.10 EEA21539.1 - 0.034 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 KR domain Topoisom_I_N PF02919.15 EEA21540.1 - 2.3e-98 327.9 4.7 2.3e-98 327.9 4.7 3.1 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 EEA21540.1 - 3.8e-97 324.1 3.2 3.8e-97 324.1 3.2 2.2 2 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 EEA21540.1 - 6e-34 115.8 1.3 2.4e-33 113.9 1.3 2.2 1 0 0 1 1 1 1 C-terminal topoisomerase domain Topoisom_I_N PF02919.15 EEA21541.1 - 2.3e-98 327.9 4.7 2.3e-98 327.9 4.7 3.1 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 EEA21541.1 - 3.8e-97 324.1 3.2 3.8e-97 324.1 3.2 2.2 2 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 EEA21541.1 - 6e-34 115.8 1.3 2.4e-33 113.9 1.3 2.2 1 0 0 1 1 1 1 C-terminal topoisomerase domain ATP-synt PF00231.19 EEA21542.1 - 5.8e-76 255.9 5.7 7.1e-76 255.6 5.7 1.0 1 0 0 1 1 1 1 ATP synthase Chalcone_2 PF16035.5 EEA21542.1 - 0.08 12.7 0.1 11 5.7 0.0 2.3 2 0 0 2 2 2 0 Chalcone isomerase like F-box PF00646.33 EEA21543.1 - 1.9e-06 27.6 0.0 6e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EEA21543.1 - 3.8e-06 26.7 0.0 8.1e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like Thioredoxin PF00085.20 EEA21544.1 - 4.4e-33 113.4 0.0 3.7e-27 94.3 0.1 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EEA21544.1 - 1.4e-07 32.0 0.1 0.0073 16.7 0.1 2.5 1 1 1 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EEA21544.1 - 2.4e-07 30.4 0.0 1.5e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EEA21544.1 - 0.0016 18.8 0.0 1.5 9.2 0.0 3.7 3 1 1 4 4 4 1 Thioredoxin-like Thioredoxin_6 PF13848.6 EEA21544.1 - 0.0026 17.7 0.0 0.74 9.7 0.0 2.9 2 1 0 3 3 3 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EEA21544.1 - 0.0055 16.6 0.0 0.017 15.1 0.0 1.7 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_7 PF13899.6 EEA21544.1 - 0.0087 16.2 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 EEA21544.1 - 0.039 14.0 1.1 1.8 8.6 0.1 2.9 3 0 0 3 3 3 0 Thioredoxin domain TraF PF13728.6 EEA21544.1 - 0.17 11.7 0.0 0.17 11.7 0.0 3.8 3 1 1 4 4 4 0 F plasmid transfer operon protein GNAT_acetyltr_2 PF13718.6 EEA21545.1 - 1.8e-98 328.5 0.0 3.3e-98 327.6 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EEA21545.1 - 1.2e-92 309.9 0.0 2.3e-92 309.0 0.0 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EEA21545.1 - 1.3e-64 217.3 0.0 3.9e-64 215.7 0.0 1.8 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 EEA21545.1 - 5e-34 116.1 0.3 1.3e-33 114.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EEA21545.1 - 0.00028 20.7 0.1 0.028 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EEA21545.1 - 0.022 15.1 0.0 0.081 13.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA21545.1 - 0.024 14.9 0.0 0.7 10.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Acetyltransf_1 PF00583.25 EEA21545.1 - 0.051 13.8 0.0 0.41 10.9 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family GHMP_kinases_N PF00288.26 EEA21545.1 - 0.11 12.7 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 GHMP kinases N terminal domain Glyco_hydro_16 PF00722.21 EEA21546.1 - 0.00014 21.4 0.2 0.00051 19.6 0.0 2.0 3 0 0 3 3 3 1 Glycosyl hydrolases family 16 Vps8 PF12816.7 EEA21547.1 - 1.7e-59 200.7 1.7 7.3e-59 198.6 0.3 2.3 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EEA21547.1 - 3.3e-05 23.8 1.7 0.091 12.6 0.1 3.5 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 EEA21547.1 - 0.0017 18.4 0.1 0.0017 18.4 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger Pox_D3 PF04580.13 EEA21547.1 - 0.0059 16.3 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Chordopoxvirinae D3 protein Vps8 PF12816.7 EEA21548.1 - 1.7e-59 200.7 1.7 7.3e-59 198.6 0.3 2.3 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EEA21548.1 - 3.3e-05 23.8 1.7 0.091 12.6 0.1 3.5 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 EEA21548.1 - 0.0017 18.4 0.1 0.0017 18.4 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger Pox_D3 PF04580.13 EEA21548.1 - 0.0059 16.3 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Chordopoxvirinae D3 protein DEAD PF00270.29 EEA21550.1 - 5e-18 65.5 0.0 1.3e-17 64.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA21550.1 - 1.1e-08 35.2 0.0 2.4e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA21550.1 - 3e-08 34.0 0.1 3.2e-07 30.7 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EEA21550.1 - 0.022 15.0 0.0 0.094 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA21550.1 - 0.043 14.2 0.1 0.3 11.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain zf-HC5HC2H_2 PF13832.6 EEA21551.1 - 1.6e-20 73.3 0.3 1.6e-20 73.3 0.3 4.2 3 1 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EEA21551.1 - 3.4e-18 65.7 0.9 3.4e-18 65.7 0.9 4.9 5 1 0 5 5 5 1 PHD-like zinc-binding domain BAH PF01426.18 EEA21551.1 - 7.8e-18 64.5 0.0 1.6e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 BAH domain PHD PF00628.29 EEA21551.1 - 6.4e-09 35.6 23.3 4e-06 26.6 5.6 5.7 6 0 0 6 6 6 2 PHD-finger PHD_2 PF13831.6 EEA21551.1 - 5.2e-07 29.1 8.0 5.2e-07 29.1 8.0 5.1 5 0 0 5 5 5 1 PHD-finger Myb_DNA-binding PF00249.31 EEA21551.1 - 0.057 13.6 0.2 0.14 12.4 0.2 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain GATA PF00320.27 EEA21551.1 - 3.7 7.3 15.1 0.15 11.7 0.9 4.0 3 0 0 3 3 3 0 GATA zinc finger PDEase_I PF00233.19 EEA21552.1 - 2.1e-70 237.2 0.0 3.8e-70 236.3 0.0 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Rdx PF10262.9 EEA21553.1 - 1.1e-21 76.8 0.0 1.7e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Rdx family Zn_clus PF00172.18 EEA21554.1 - 2.8e-09 37.0 10.6 7.2e-09 35.6 10.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA21554.1 - 5.5e-08 32.2 0.7 1.2e-07 31.0 0.7 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 EEA21554.1 - 1.1e-06 29.0 6.0 0.0019 18.8 1.0 3.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA21554.1 - 3.9e-05 23.9 12.8 0.00042 20.6 0.9 3.7 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EEA21554.1 - 0.0047 16.9 1.3 0.0047 16.9 1.3 2.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EEA21554.1 - 0.019 14.7 0.2 0.07 12.9 0.2 1.9 1 0 0 1 1 1 0 zinc-finger C2H2-type G-gamma PF00631.22 EEA21555.1 - 6.9e-24 83.6 0.0 8e-24 83.4 0.0 1.1 1 0 0 1 1 1 1 GGL domain DUF3220 PF11516.8 EEA21555.1 - 0.18 12.1 0.0 0.23 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) PCI PF01399.27 EEA21556.1 - 9e-12 45.4 0.4 2.4e-10 40.9 0.0 3.0 2 0 0 2 2 2 1 PCI domain DUF4776 PF16003.5 EEA21556.1 - 4.6 6.1 41.9 0.078 12.0 26.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) ATG16 PF08614.11 EEA21557.1 - 0.85 9.8 9.8 0.056 13.7 2.6 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Acetyltransf_10 PF13673.7 EEA21558.1 - 1.2e-08 35.0 0.0 2e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA21558.1 - 1.3e-08 35.1 0.0 1.9e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA21558.1 - 1.3e-06 28.7 0.0 1.9e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA21558.1 - 8.3e-06 25.7 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EEA21558.1 - 0.067 13.3 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 EEA21559.1 - 4.5e-12 45.6 55.9 2.5e-09 36.6 17.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Herpes_LMP1 PF05297.11 EEA21559.1 - 3.2 6.8 7.5 5.9 6.0 7.5 1.5 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) PH PF00169.29 EEA21560.1 - 3e-07 30.9 0.0 2.5e-06 28.0 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EEA21560.1 - 0.0086 16.4 0.0 0.022 15.1 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain zf-C2H2 PF00096.26 EEA21561.1 - 2.4e-27 93.8 58.8 5.9e-05 23.3 0.1 11.2 10 1 1 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA21561.1 - 3.1e-21 74.2 55.5 0.025 15.4 0.1 10.7 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA21561.1 - 6.5e-08 32.7 64.4 0.00041 20.7 1.1 11.5 13 0 0 13 13 12 6 Zinc-finger double domain FOXP-CC PF16159.5 EEA21561.1 - 1.1e-05 26.0 31.0 1.3 9.7 0.0 9.2 5 2 5 10 10 10 2 FOXP coiled-coil domain zf_Hakai PF18408.1 EEA21561.1 - 0.00036 20.2 15.2 1.1 9.1 4.0 6.3 5 0 0 5 5 5 1 C2H2 Hakai zinc finger domain zf-C2H2_8 PF15909.5 EEA21561.1 - 0.00045 20.5 25.3 0.032 14.5 2.0 4.8 2 1 3 5 5 5 3 C2H2-type zinc ribbon GAGA PF09237.11 EEA21561.1 - 0.00054 19.7 4.1 0.0007 19.4 1.0 2.7 3 0 0 3 3 3 1 GAGA factor zf-C2H2_jaz PF12171.8 EEA21561.1 - 0.00069 19.8 24.9 5.4 7.4 0.1 8.9 10 1 0 10 10 10 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EEA21561.1 - 0.00089 19.0 1.0 0.00089 19.0 1.0 9.2 10 0 0 10 10 10 2 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 EEA21561.1 - 0.012 16.3 22.0 3.1 8.5 0.4 6.0 1 1 5 6 6 6 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EEA21561.1 - 0.036 13.8 20.9 0.16 11.7 0.0 5.8 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-met PF12874.7 EEA21561.1 - 0.32 11.5 20.1 12 6.4 0.0 7.6 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EEA21561.1 - 0.86 9.7 0.0 0.86 9.7 0.0 7.8 9 1 1 10 10 10 0 C2H2-type zinc finger zf-C2H2_9 PF16293.5 EEA21561.1 - 1.2 9.0 11.9 7 6.6 0.3 5.0 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) Ogr_Delta PF04606.12 EEA21561.1 - 8.5 6.4 18.1 13 5.9 0.0 4.5 3 2 1 4 4 4 0 Ogr/Delta-like zinc finger RNA_pol_Rpb6 PF01192.22 EEA21562.1 - 3.9e-15 55.5 0.0 6.1e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 COPIIcoated_ERV PF07970.12 EEA21563.1 - 6.6e-85 284.4 0.0 8.8e-85 284.0 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EEA21563.1 - 2.1e-31 108.1 0.0 4.7e-30 103.8 0.0 2.3 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) TAP_C PF03943.13 EEA21564.1 - 2.9e-15 55.6 0.5 5.6e-15 54.7 0.5 1.5 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.7 EEA21564.1 - 4.9e-07 30.0 11.0 0.00024 21.4 8.2 2.8 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA21564.1 - 1.1e-06 28.2 3.2 2.9e-06 26.9 3.2 1.8 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.6 EEA21564.1 - 2.1e-06 27.4 0.1 4.1e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeat NTF2 PF02136.20 EEA21564.1 - 9.3e-05 23.0 0.0 0.00052 20.6 0.0 2.3 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_9 PF18444.1 EEA21564.1 - 0.0009 19.0 0.0 0.0023 17.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif LRR_6 PF13516.6 EEA21564.1 - 0.032 14.3 0.1 0.032 14.3 0.1 2.7 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 EEA21564.1 - 0.13 12.9 5.3 7 7.6 0.2 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat EF-hand_6 PF13405.6 EEA21564.1 - 0.35 10.9 1.6 1.3 9.2 0.9 2.4 2 0 0 2 2 2 0 EF-hand domain Vps53_N PF04100.12 EEA21565.1 - 2.6e-107 359.1 8.7 4.5e-107 358.3 8.7 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.9 EEA21565.1 - 1e-08 34.8 7.9 1e-08 34.8 7.9 1.6 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EEA21565.1 - 1.9e-06 27.8 0.0 6.9e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) COG2 PF06148.11 EEA21565.1 - 3.1e-06 27.3 2.5 3.1e-06 27.3 2.5 2.2 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Zw10 PF06248.13 EEA21565.1 - 0.0049 15.5 7.8 0.0098 14.5 7.8 1.4 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Sigma70_ner PF04546.13 EEA21565.1 - 0.01 15.7 5.2 0.024 14.5 5.2 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region XhlA PF10779.9 EEA21565.1 - 0.019 15.1 1.8 0.084 13.1 1.8 2.1 1 0 0 1 1 1 0 Haemolysin XhlA Spc7 PF08317.11 EEA21565.1 - 0.047 12.6 9.0 0.086 11.7 9.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Sec8_exocyst PF04048.14 EEA21565.1 - 0.097 12.6 3.8 0.29 11.0 3.8 1.8 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF5339 PF17274.2 EEA21565.1 - 0.1 13.5 5.3 4.4 8.2 0.4 3.0 1 1 1 2 2 2 0 Family of unknown function (DUF5339) FapA PF03961.13 EEA21565.1 - 0.12 11.0 2.8 0.21 10.2 2.8 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A LtuB PF17455.2 EEA21565.1 - 0.13 12.9 0.1 0.35 11.5 0.1 1.7 1 0 0 1 1 1 0 Late transcription unit B Baculo_PEP_C PF04513.12 EEA21565.1 - 0.16 12.0 7.6 0.31 11.1 6.2 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_L PF02601.15 EEA21565.1 - 0.17 11.4 5.1 0.48 10.0 5.1 1.8 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5082 PF16888.5 EEA21565.1 - 0.32 11.3 5.2 3.4 8.0 0.9 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF1515 PF07439.11 EEA21565.1 - 0.34 10.9 4.5 0.7 9.9 3.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) BLOC1_2 PF10046.9 EEA21565.1 - 0.58 10.5 6.0 1.1 9.6 3.8 2.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 EEA21565.1 - 0.62 10.6 10.0 1.2 9.7 8.8 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region Atg14 PF10186.9 EEA21565.1 - 0.72 8.9 12.3 0.17 11.0 8.6 1.7 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 BRE1 PF08647.11 EEA21565.1 - 1.5 8.9 9.6 0.9 9.6 5.9 2.6 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Fib_alpha PF08702.10 EEA21565.1 - 1.7 8.8 6.9 18 5.5 6.9 2.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Syntaxin_2 PF14523.6 EEA21565.1 - 1.8 9.0 7.7 4.4 7.7 4.9 3.2 2 1 0 2 2 2 0 Syntaxin-like protein DUF1664 PF07889.12 EEA21565.1 - 1.9 8.5 5.5 2 8.5 3.2 2.3 2 0 0 2 2 1 0 Protein of unknown function (DUF1664) HIP1_clath_bdg PF16515.5 EEA21565.1 - 5.3 7.7 10.0 2.7 8.7 7.0 2.1 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 EEA21565.1 - 6.2 7.5 5.6 4.2 8.1 1.9 2.6 1 1 2 3 3 2 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 EEA21565.1 - 6.8 6.8 13.1 0.81 9.7 7.2 2.5 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.12 EEA21565.1 - 7.9 7.0 7.2 16 6.1 3.0 3.5 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Peptidase_S9 PF00326.21 EEA21566.1 - 1.8e-31 109.3 0.9 3.3e-31 108.4 0.9 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF4149 PF13664.6 EEA21567.1 - 8.2e-23 80.7 1.5 2.1e-22 79.4 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Ribosomal_L10 PF00466.20 EEA21568.1 - 1.2e-22 79.9 0.1 3.1e-22 78.6 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EEA21568.1 - 1e-21 76.7 0.1 2.1e-21 75.7 0.1 1.6 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EEA21568.1 - 2.8e-18 66.3 6.4 2.8e-18 66.3 6.4 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein WD40 PF00400.32 EEA21569.1 - 4.1e-05 24.3 3.1 0.15 13.0 0.1 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Lactonase PF10282.9 EEA21569.1 - 0.052 12.8 0.0 0.15 11.3 0.0 1.7 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller ANAPC4_WD40 PF12894.7 EEA21569.1 - 0.055 13.8 0.0 30 5.0 0.0 3.2 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain URO-D PF01208.17 EEA21570.1 - 2.8e-128 427.9 0.0 3.1e-128 427.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) dCMP_cyt_deam_1 PF00383.23 EEA21571.1 - 3.7e-22 78.1 0.0 5.1e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA21571.1 - 9.2e-19 67.6 0.0 1.1e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EEA21571.1 - 0.0003 20.8 0.4 0.059 13.5 0.8 2.2 1 1 1 2 2 2 2 Bd3614-like deaminase SNAD4 PF18750.1 EEA21571.1 - 0.004 17.3 0.0 0.028 14.5 0.0 2.0 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 EEA21571.1 - 0.014 15.5 0.1 0.22 11.5 0.1 2.0 1 1 0 1 1 1 0 APOBEC2 NAD1 PF18778.1 EEA21571.1 - 0.019 15.1 0.2 0.21 11.7 0.2 2.1 1 1 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 EEA21571.1 - 0.029 14.3 0.1 0.27 11.1 0.1 2.0 1 1 0 1 1 1 0 APOBEC-like N-terminal domain NAD2 PF18782.1 EEA21571.1 - 0.05 13.7 0.0 0.15 12.1 0.0 1.8 1 1 0 1 1 1 0 Novel AID APOBEC clade 2 DUF3725 PF12523.8 EEA21571.1 - 0.14 12.5 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) DnaJ_C PF01556.18 EEA21572.1 - 1.3e-39 135.7 0.1 1.7e-39 135.3 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA21572.1 - 5e-26 90.6 1.4 8.4e-26 89.9 1.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EEA21572.1 - 1.1e-15 57.7 18.5 2e-15 56.9 18.5 1.4 1 0 0 1 1 1 1 DnaJ central domain DUF1356 PF07092.12 EEA21572.1 - 0.12 11.6 2.7 1.4 8.1 0.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1356) DUF2614 PF11023.8 EEA21572.1 - 0.28 11.3 6.0 1.1 9.4 1.0 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain HypA PF01155.19 EEA21572.1 - 1.2 9.2 9.7 0.64 10.1 2.4 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EEA21572.1 - 1.2 9.2 7.4 1.9 8.6 1.8 2.2 1 1 0 2 2 2 0 zinc-ribbons Anti-TRAP PF15777.5 EEA21572.1 - 1.7 8.7 17.3 0.15 12.0 2.7 2.9 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein Sulfate_transp PF00916.20 EEA21573.1 - 9.9e-109 363.6 21.0 1.3e-108 363.1 21.0 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EEA21573.1 - 4.4e-08 32.8 0.0 1.4e-07 31.2 0.0 1.7 2 0 0 2 2 2 1 STAS domain MFS_MOT1 PF16983.5 EEA21573.1 - 0.0012 19.2 2.3 0.0012 19.2 2.3 3.6 2 1 1 3 3 3 2 Molybdate transporter of MFS superfamily RTA1 PF04479.13 EEA21574.1 - 6.3e-54 182.7 14.4 6.3e-54 182.7 14.4 1.8 1 1 1 2 2 2 1 RTA1 like protein Zn_clus PF00172.18 EEA21575.1 - 3.9e-08 33.3 10.8 6.2e-08 32.6 10.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rab5ip PF07019.12 EEA21576.1 - 2.3e-22 79.4 2.6 3.2e-22 78.9 2.6 1.2 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) SAM_2 PF07647.17 EEA21577.1 - 2.4e-07 30.8 0.1 5.6e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EEA21577.1 - 0.0017 18.8 0.2 0.0036 17.7 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 EEA21577.1 - 0.11 12.8 0.2 0.27 11.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DHC_N1 PF08385.12 EEA21577.1 - 0.26 9.9 3.4 0.49 9.0 3.4 1.4 1 1 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 TPR_19 PF14559.6 EEA21578.1 - 1.1e-18 67.5 16.4 6.1e-07 29.9 0.0 8.7 7 2 3 10 10 10 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA21578.1 - 2.5e-16 58.9 25.2 0.0027 18.4 1.4 11.4 10 2 1 11 11 11 5 Tetratricopeptide repeat TPR_7 PF13176.6 EEA21578.1 - 1.2e-11 43.7 16.6 0.026 14.5 0.0 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 EEA21578.1 - 2.5e-09 36.5 29.3 0.0094 15.7 0.0 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 EEA21578.1 - 2.6e-09 36.5 43.3 0.1 12.7 0.1 11.2 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_12 PF13424.6 EEA21578.1 - 2.2e-08 34.2 24.3 0.017 15.4 0.0 7.8 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EEA21578.1 - 1.7e-07 30.9 27.6 0.0042 17.2 0.0 8.5 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 EEA21578.1 - 1.3e-06 27.9 14.9 0.35 10.6 0.8 7.4 8 1 1 9 9 9 3 TPR repeat TPR_16 PF13432.6 EEA21578.1 - 1.9e-06 28.4 0.0 1.9e-06 28.4 0.0 8.0 9 0 0 9 9 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA21578.1 - 6.6e-06 26.3 20.6 0.16 12.3 1.6 6.8 7 1 1 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 EEA21578.1 - 7.5e-05 22.5 4.8 0.057 13.1 0.1 4.8 4 1 1 5 5 5 1 26S proteasome subunit RPN7 TPR_9 PF13371.6 EEA21578.1 - 0.0014 18.7 9.9 0.21 11.8 0.1 5.7 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA21578.1 - 0.002 18.3 20.7 0.48 10.9 0.2 8.6 11 0 0 11 11 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA21578.1 - 0.0042 16.5 5.0 14 4.9 0.1 5.2 6 0 0 6 6 6 0 MalT-like TPR region Alkyl_sulf_dimr PF14863.6 EEA21578.1 - 0.0048 17.3 1.3 0.66 10.4 0.0 3.1 3 0 0 3 3 3 1 Alkyl sulfatase dimerisation BTAD PF03704.17 EEA21578.1 - 0.014 15.8 5.5 0.04 14.3 0.6 3.5 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_20 PF14561.6 EEA21578.1 - 0.015 15.6 1.9 31 5.0 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ChAPs PF09295.10 EEA21578.1 - 0.073 12.1 0.0 0.61 9.0 0.0 2.3 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.6 EEA21578.1 - 0.41 11.4 18.5 19 6.2 0.0 7.8 8 0 0 8 8 6 0 Tetratricopeptide repeat CDC45 PF02724.14 EEA21578.1 - 2.1 6.5 5.7 1.3 7.2 3.8 1.5 2 0 0 2 2 2 0 CDC45-like protein MFS_1 PF07690.16 EEA21579.1 - 3.2e-22 79.0 48.9 2.6e-15 56.2 26.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CH PF00307.31 EEA21580.1 - 2.1e-06 27.9 0.1 0.0017 18.5 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain IQ PF00612.27 EEA21580.1 - 0.29 11.0 3.4 1 9.3 3.4 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif Vezatin PF12632.7 EEA21581.1 - 3.7e-66 223.3 0.2 6.5e-66 222.5 0.0 1.5 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes PLDc_N PF13396.6 EEA21581.1 - 0.0026 17.7 1.2 0.005 16.7 1.2 1.5 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal APC_u14 PF16635.5 EEA21581.1 - 0.062 13.8 0.1 0.28 11.8 0.0 2.1 2 0 0 2 2 2 0 Unstructured region on APC between SAMP and APC_crr NMN_transporter PF04973.12 EEA21581.1 - 0.17 11.8 0.7 0.28 11.2 0.7 1.2 1 0 0 1 1 1 0 Nicotinamide mononucleotide transporter DUF2457 PF10446.9 EEA21582.1 - 7e-151 503.5 23.8 7e-151 503.5 23.8 3.1 2 1 1 3 3 3 1 Protein of unknown function (DUF2457) Arf PF00025.21 EEA21583.1 - 1.6e-64 216.6 0.0 1.8e-64 216.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EEA21583.1 - 4.6e-10 39.2 0.0 1.9e-06 27.3 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EEA21583.1 - 5.2e-08 32.5 0.0 6.4e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EEA21583.1 - 3.8e-07 30.3 0.0 1.2e-06 28.7 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EEA21583.1 - 4.8e-07 29.8 0.0 6.3e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EEA21583.1 - 7.3e-06 25.7 0.0 1.1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EEA21583.1 - 0.00013 21.5 0.0 0.00014 21.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA21583.1 - 0.081 12.4 0.0 2.3 7.7 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EEA21583.1 - 0.17 11.4 0.0 9.7 5.7 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 EEA21584.1 - 5.4e-60 201.8 0.0 6.5e-60 201.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EEA21584.1 - 4.4e-10 39.2 0.0 1.8e-06 27.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EEA21584.1 - 5e-08 32.6 0.0 6.2e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EEA21584.1 - 3.6e-07 30.4 0.0 1.2e-06 28.7 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EEA21584.1 - 4.7e-07 29.9 0.0 6.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EEA21584.1 - 7.1e-06 25.7 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EEA21584.1 - 0.00012 21.5 0.0 0.00013 21.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA21584.1 - 0.075 12.6 0.0 3.8 7.0 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EEA21584.1 - 0.17 11.5 0.0 9.5 5.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Metallophos PF00149.28 EEA21585.1 - 3.9e-40 138.5 0.1 5.2e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA21585.1 - 1.1e-22 80.1 2.6 1.5e-22 79.8 1.7 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Metallophos PF00149.28 EEA21586.1 - 3.6e-40 138.7 0.1 4.5e-40 138.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA21586.1 - 1.1e-22 80.2 2.6 1.4e-22 79.9 1.7 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Metallophos PF00149.28 EEA21587.1 - 3.5e-40 138.7 0.1 4.5e-40 138.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA21587.1 - 1.1e-22 80.2 2.6 1.4e-22 79.9 1.7 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain LRR_8 PF13855.6 EEA21588.1 - 2.3e-13 49.7 18.8 1.3e-07 31.3 1.4 4.6 3 1 3 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 EEA21588.1 - 5.9e-13 48.8 10.2 0.0011 19.3 0.3 4.6 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EEA21588.1 - 5.2e-06 26.3 10.2 4.1 8.3 0.1 7.1 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 EEA21588.1 - 8.1e-05 22.2 0.3 0.0053 16.3 0.6 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EEA21588.1 - 0.064 13.3 17.3 0.94 9.7 0.5 6.0 6 0 0 6 6 6 0 Leucine Rich repeat DUF3336 PF11815.8 EEA21589.1 - 1.1e-48 164.5 7.0 1.6e-48 163.9 7.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EEA21589.1 - 3.5e-19 69.8 0.1 9e-18 65.2 0.0 2.4 2 0 0 2 2 2 1 Patatin-like phospholipase TPR_MLP1_2 PF07926.12 EEA21589.1 - 0.1 12.7 1.1 0.17 11.9 1.1 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein GHMP_kinases_C PF08544.13 EEA21589.1 - 0.13 12.6 0.1 1 9.8 0.0 2.4 2 0 0 2 2 2 0 GHMP kinases C terminal Ank_2 PF12796.7 EEA21590.1 - 2.9e-74 245.7 9.8 7e-14 52.2 0.1 7.1 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA21590.1 - 4.4e-68 224.8 9.0 3.9e-12 46.4 0.0 8.6 7 1 1 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 EEA21590.1 - 3.8e-52 172.6 21.4 1.8e-05 25.0 0.0 13.5 12 1 1 13 13 13 10 Ankyrin repeat Ank_3 PF13606.6 EEA21590.1 - 4.6e-51 164.8 13.1 0.00018 21.7 0.0 13.7 13 0 0 13 13 13 10 Ankyrin repeat Ank_5 PF13857.6 EEA21590.1 - 2.5e-49 164.7 23.9 2.4e-06 27.7 0.6 12.2 3 2 10 13 13 13 11 Ankyrin repeats (many copies) DUF1612 PF07756.12 EEA21590.1 - 0.09 13.0 0.1 0.29 11.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) PCNA_N PF00705.18 EEA21591.1 - 6.1e-54 181.1 3.2 1.1e-53 180.3 3.2 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EEA21591.1 - 4e-49 166.0 0.1 2.6e-48 163.4 0.0 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EEA21591.1 - 1e-07 31.7 0.1 1.3e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EEA21591.1 - 8.9e-06 25.0 0.3 0.00091 18.4 0.3 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 EEA21591.1 - 0.00068 18.8 0.3 0.0051 16.0 0.1 2.0 1 1 1 2 2 2 1 Hus1-like protein DUF5353 PF17304.2 EEA21592.1 - 0.068 12.9 0.3 0.32 10.8 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5353) Sec61_beta PF03911.16 EEA21593.1 - 2.5e-17 62.6 0.8 3.8e-17 62.0 0.8 1.3 1 0 0 1 1 1 1 Sec61beta family DDE_3 PF13358.6 EEA21594.1 - 7.4e-13 48.5 0.1 2.1e-12 47.0 0.1 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA21594.1 - 6.5e-10 39.1 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA21594.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA21594.1 - 0.0078 16.1 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA21594.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA21594.1 - 0.012 16.0 0.1 13 6.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA21594.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA21594.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA21594.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA21594.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA21594.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 SSF PF00474.17 EEA21595.1 - 8e-16 57.9 31.7 1.3e-15 57.2 31.7 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family LIDHydrolase PF10230.9 EEA21596.1 - 5.7e-51 173.6 0.0 7.3e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 EEA21596.1 - 0.00057 20.6 0.0 0.0007 20.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA21596.1 - 0.0007 18.9 0.0 0.42 9.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF900 PF05990.12 EEA21596.1 - 0.0022 17.5 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.20 EEA21596.1 - 0.016 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA21596.1 - 0.025 14.3 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein LCAT PF02450.15 EEA21596.1 - 0.058 12.6 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.13 EEA21596.1 - 0.12 12.2 0.0 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase Dynein_light PF01221.18 EEA21597.1 - 1.4e-23 83.0 0.7 2.4e-23 82.2 0.7 1.3 1 0 0 1 1 1 1 Dynein light chain type 1 HU-CCDC81_bac_1 PF18174.1 EEA21597.1 - 0.12 12.3 0.0 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 1 RRM_1 PF00076.22 EEA21598.1 - 1.2e-72 239.6 2.4 2.5e-19 68.9 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA21598.1 - 3e-07 30.2 0.0 0.014 15.2 0.0 4.5 5 0 0 5 5 5 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EEA21598.1 - 5.5e-07 29.5 0.1 0.26 11.3 0.0 4.4 5 0 0 5 5 5 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EEA21598.1 - 4.1e-05 23.6 0.4 12 6.1 0.0 5.2 5 0 0 5 5 5 1 Limkain b1 RRM_5 PF13893.6 EEA21598.1 - 0.00018 21.1 0.0 0.013 15.1 0.0 3.1 3 1 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA21598.1 - 0.00066 19.8 0.0 25 5.1 0.0 4.2 4 0 0 4 4 4 1 RNA recognition motif RRM_2 PF04059.12 EEA21598.1 - 0.022 14.9 0.0 2.2 8.6 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif 2 TEA PF01285.18 EEA21599.1 - 5.9e-27 93.5 0.0 1.5e-26 92.2 0.0 1.7 1 0 0 1 1 1 1 TEA/ATTS domain Aldo_ket_red PF00248.21 EEA21600.1 - 2.6e-43 148.3 0.0 3.9e-43 147.7 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family DUF2380 PF09533.10 EEA21600.1 - 0.15 11.7 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) LRR_4 PF12799.7 EEA21602.1 - 3.5e-34 116.3 37.5 5.3e-09 36.2 5.9 7.1 3 2 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA21602.1 - 2e-20 72.3 35.8 7.1e-06 25.7 5.2 6.4 3 2 2 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 EEA21602.1 - 3.3e-14 52.8 17.6 5.4e-06 26.0 2.7 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EEA21602.1 - 9.2e-05 22.5 27.1 6.2 7.8 0.3 8.7 8 2 0 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.6 EEA21602.1 - 0.0016 18.3 26.4 2.8 8.2 0.1 7.7 7 0 0 7 7 7 3 Leucine Rich repeat NIF PF03031.18 EEA21603.1 - 3.4e-54 182.8 0.1 4.8e-54 182.4 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ABC_membrane_2 PF06472.15 EEA21604.1 - 3.6e-88 295.5 1.2 4.5e-88 295.1 0.2 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EEA21604.1 - 6.1e-15 55.9 0.0 1.1e-14 55.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EEA21604.1 - 0.0036 17.2 0.0 0.0073 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA21604.1 - 0.01 16.4 2.9 0.18 12.3 2.9 2.3 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EEA21604.1 - 0.039 14.4 0.0 0.12 12.8 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EEA21604.1 - 0.1 12.4 0.0 0.38 10.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 EEA21604.1 - 0.1 12.0 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EEA21604.1 - 0.11 12.3 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EEA21604.1 - 0.11 12.2 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 EEA21604.1 - 0.14 12.4 0.1 0.59 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Acyl_transf_3 PF01757.22 EEA21606.1 - 6.9e-22 78.0 36.7 1.1e-20 74.1 36.7 2.4 1 1 0 1 1 1 1 Acyltransferase family DUF3328 PF11807.8 EEA21607.1 - 1e-24 87.6 0.0 1.4e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EEA21608.1 - 0.037 13.8 3.3 12 5.6 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3328) Peptidase_M3 PF01432.20 EEA21609.1 - 1.7e-145 485.8 0.0 2.2e-145 485.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 GFA PF04828.14 EEA21610.1 - 2.1e-17 63.2 2.3 2.1e-17 63.2 2.3 2.0 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Zn_clus PF00172.18 EEA21611.1 - 1.7e-07 31.2 12.7 3.2e-07 30.4 12.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Leukocidin PF07968.12 EEA21611.1 - 0.086 12.7 1.2 0.19 11.6 0.1 1.8 2 0 0 2 2 2 0 Leukocidin/Hemolysin toxin family Fibrinogen_BP PF08017.11 EEA21612.1 - 5.7e-24 84.3 51.4 6.6e-23 80.8 51.4 2.0 1 1 0 1 1 1 1 Fibrinogen binding protein DUF4169 PF13770.6 EEA21612.1 - 0.34 11.2 62.9 2.3 8.6 0.9 9.6 2 2 5 8 8 8 0 Domain of unknown function (DUF4169) DUF3328 PF11807.8 EEA21613.1 - 0.00086 19.1 5.0 0.0034 17.2 5.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF1057 PF06342.12 EEA21613.1 - 0.2 10.6 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) MFS_2 PF13347.6 EEA21614.1 - 2.1e-10 39.8 7.2 2.1e-10 39.8 7.2 2.6 3 0 0 3 3 3 2 MFS/sugar transport protein TMEM208_SND2 PF05620.11 EEA21614.1 - 1.1 9.0 4.0 3.7 7.3 0.0 3.4 4 0 0 4 4 4 0 SRP-independent targeting protein 2/TMEM208 Clr2 PF10383.9 EEA21615.1 - 1.2e-31 110.5 0.2 4e-31 108.8 0.0 2.0 2 0 0 2 2 2 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 EEA21615.1 - 7.4e-19 68.3 0.5 1.8e-18 67.1 0.5 1.7 1 0 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 TFIIA PF03153.13 EEA21615.1 - 0.36 10.8 5.6 0.56 10.1 5.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 EEA21615.1 - 3.6 7.3 6.6 6.4 6.4 6.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 EEA21615.1 - 4 5.4 6.5 5.8 4.9 6.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi AT_hook PF02178.19 EEA21615.1 - 4.8 7.4 7.6 16 5.8 2.4 3.2 2 0 0 2 2 2 0 AT hook motif 2OG-FeII_Oxy PF03171.20 EEA21616.1 - 0.00087 19.7 0.0 0.0021 18.5 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EEA21616.1 - 0.0034 18.1 0.0 0.0064 17.2 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal tRNA-synt_2 PF00152.20 EEA21617.1 - 6.7e-75 252.1 0.0 9e-75 251.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA21617.1 - 5.6e-10 39.1 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EEA21617.1 - 1.3e-05 24.8 0.1 0.0052 16.3 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 EEA21617.1 - 0.052 13.8 0.0 0.098 12.9 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain zf-Tim10_DDP PF02953.15 EEA21618.1 - 2e-22 78.6 0.5 2.4e-22 78.3 0.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Peptidase_S76 PF13611.6 EEA21618.1 - 0.13 12.6 0.1 0.15 12.4 0.1 1.3 1 1 0 1 1 1 0 Serine peptidase of plant viral polyprotein, P1 NPV_P10 PF05531.12 EEA21619.1 - 0.047 14.2 0.1 2.2 8.8 0.0 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Tektin PF03148.14 EEA21619.1 - 0.055 12.2 0.1 0.089 11.5 0.1 1.2 1 0 0 1 1 1 0 Tektin family PG_binding_1 PF01471.18 EEA21619.1 - 0.065 13.4 0.1 5.8 7.2 0.0 3.5 4 0 0 4 4 4 0 Putative peptidoglycan binding domain APG6_N PF17675.1 EEA21619.1 - 0.84 10.2 3.4 2.2 8.8 3.4 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4164 PF13747.6 EEA21619.1 - 2.4 8.5 5.1 1.5 9.2 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) CLTH PF10607.9 EEA21620.1 - 1e-32 113.1 0.0 1.9e-32 112.2 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EEA21620.1 - 1.1e-08 35.0 0.4 2.3e-08 33.9 0.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EEA21620.1 - 0.0003 20.3 0.2 0.0003 20.3 0.2 1.8 2 0 0 2 2 2 1 Rtf2 RING-finger zf-RING_5 PF14634.6 EEA21620.1 - 0.00067 19.6 0.4 0.0011 18.8 0.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EEA21620.1 - 0.001 19.4 0.7 0.0018 18.5 0.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA21620.1 - 0.0021 17.8 1.5 0.0045 16.8 1.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA21620.1 - 0.0067 16.3 1.3 0.013 15.4 1.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EEA21620.1 - 0.0093 15.8 1.2 0.018 14.9 1.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA21620.1 - 0.014 15.2 0.6 0.025 14.4 0.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA21620.1 - 0.093 12.9 1.2 0.2 11.9 1.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING EPO_TPO PF00758.18 EEA21620.1 - 0.15 12.1 0.2 0.67 10.0 0.1 2.0 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin CLTH PF10607.9 EEA21621.1 - 6.3e-33 113.8 0.0 9.2e-33 113.2 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EEA21621.1 - 7.1e-09 35.5 0.4 1.5e-08 34.5 0.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EEA21621.1 - 0.00012 21.6 0.2 0.00019 20.9 0.2 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_5 PF14634.6 EEA21621.1 - 0.00043 20.2 0.4 0.00072 19.5 0.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EEA21621.1 - 0.00064 20.0 0.7 0.0012 19.2 0.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA21621.1 - 0.0014 18.4 1.5 0.0029 17.4 1.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA21621.1 - 0.0042 16.9 1.3 0.0082 16.0 1.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EEA21621.1 - 0.006 16.4 1.2 0.011 15.5 1.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA21621.1 - 0.0092 15.8 0.6 0.016 15.0 0.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA21621.1 - 0.068 13.3 1.2 0.13 12.5 1.2 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING BTB PF00651.31 EEA21622.1 - 7.8e-07 29.3 0.0 3.5e-06 27.2 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.15 EEA21622.1 - 0.014 15.5 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain PCI PF01399.27 EEA21623.1 - 1.1e-08 35.6 0.0 2.3e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 PCI domain Cohesin_load PF10345.9 EEA21623.1 - 0.075 11.5 0.0 0.12 10.8 0.0 1.2 1 0 0 1 1 1 0 Cohesin loading factor TPR_2 PF07719.17 EEA21623.1 - 0.14 12.4 0.1 0.42 10.8 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Ribosomal_L18A PF01775.17 EEA21624.1 - 9.1e-55 183.9 0.1 1.1e-54 183.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Ribosomal_L18A PF01775.17 EEA21625.1 - 2.3e-44 150.4 0.3 2.9e-44 150.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A NAD_binding_1 PF00175.21 EEA21626.1 - 4e-34 117.5 0.0 7.4e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EEA21626.1 - 4.5e-24 84.7 0.0 1.5e-23 83.0 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EEA21626.1 - 1.3e-09 38.3 0.0 9e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EEA21627.1 - 3.3e-34 117.8 0.0 5.1e-34 117.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EEA21627.1 - 4.9e-24 84.6 0.0 1e-23 83.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EEA21627.1 - 9.2e-10 38.8 0.0 6.9e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain HMG_box PF00505.19 EEA21628.1 - 1.1e-10 41.7 1.0 2.7e-10 40.5 1.0 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA21628.1 - 1.3e-05 25.7 0.4 3.9e-05 24.2 0.4 1.9 1 0 0 1 1 1 1 HMG-box domain NOA36 PF06524.12 EEA21628.1 - 0.29 10.4 5.5 0.63 9.3 5.5 1.5 1 0 0 1 1 1 0 NOA36 protein Inhibitor_I53 PF11714.8 EEA21628.1 - 0.74 10.0 5.9 2.1 8.6 5.9 1.8 1 0 0 1 1 1 0 Thrombin inhibitor Madanin CDC45 PF02724.14 EEA21628.1 - 0.89 7.8 11.3 1.3 7.3 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein GEN1_C PF18380.1 EEA21628.1 - 4.7 8.2 0.0 4.7 8.2 0.0 3.1 2 1 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain DUF4611 PF15387.6 EEA21628.1 - 4.8 7.5 12.9 25 5.2 12.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 EEA21628.1 - 8.3 4.4 9.5 13 3.7 9.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 EEA21628.1 - 9.9 4.8 9.4 14 4.3 9.4 1.2 1 0 0 1 1 1 0 Presenilin Amidohydro_1 PF01979.20 EEA21629.1 - 7.2e-77 259.0 0.6 1.5e-76 258.0 0.6 1.5 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 EEA21629.1 - 1.3e-56 190.1 1.1 3.1e-56 188.9 1.1 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 EEA21629.1 - 1.8e-41 140.1 0.2 1.1e-40 137.5 0.0 2.1 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.18 EEA21629.1 - 2.3e-39 133.7 0.4 2.1e-38 130.6 0.2 2.3 2 0 0 2 2 2 1 Urease, gamma subunit Amidohydro_3 PF07969.11 EEA21629.1 - 8.7e-10 38.7 0.1 0.00017 21.2 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.14 EEA21629.1 - 0.2 11.4 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase zf-RING_2 PF13639.6 EEA21630.1 - 6.1e-11 42.5 6.0 1.1e-10 41.7 6.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EEA21630.1 - 4.4e-09 35.9 3.7 4.4e-09 35.9 3.7 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA21630.1 - 1.6e-06 27.9 5.4 3.2e-06 26.9 5.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA21630.1 - 2e-06 27.6 3.5 4.1e-06 26.6 3.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA21630.1 - 6.5e-06 26.1 2.5 7.1e-06 26.0 1.2 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA21630.1 - 2.2e-05 24.3 2.7 4.1e-05 23.5 2.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA21630.1 - 0.00027 20.7 3.5 0.0005 19.9 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA21630.1 - 0.00031 21.0 6.1 0.0017 18.6 6.1 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EEA21630.1 - 0.0015 18.3 4.6 0.0033 17.3 4.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EEA21630.1 - 0.0038 17.3 1.2 0.0091 16.0 0.9 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4381 PF14316.6 EEA21630.1 - 0.045 14.0 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Zn_ribbon_17 PF17120.5 EEA21630.1 - 0.068 12.8 3.0 0.13 11.9 3.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EEA21630.1 - 0.17 12.2 2.1 0.45 10.9 2.1 1.8 1 0 0 1 1 1 0 RING-like domain zf-Nse PF11789.8 EEA21630.1 - 0.37 10.6 4.1 0.79 9.6 4.1 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Ada3 PF10198.9 EEA21631.1 - 2.2e-51 173.4 0.1 2.2e-51 173.4 0.1 2.0 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 NPR2 PF06218.11 EEA21632.1 - 2.4e-131 438.5 5.7 1.2e-127 426.3 0.0 3.0 1 1 0 2 2 2 2 Nitrogen permease regulator 2 MULE PF10551.9 EEA21632.1 - 0.095 13.1 0.2 0.25 11.8 0.0 1.8 2 0 0 2 2 2 0 MULE transposase domain SPX PF03105.19 EEA21632.1 - 2.2 8.1 13.5 1.7 8.5 7.7 2.1 2 0 0 2 2 2 0 SPX domain SinI PF08671.10 EEA21633.1 - 0.028 14.2 3.6 0.47 10.3 2.5 2.6 2 0 0 2 2 2 0 Anti-repressor SinI DUF1656 PF07869.12 EEA21633.1 - 0.23 11.5 0.6 0.45 10.5 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) SinI PF08671.10 EEA21634.1 - 0.028 14.2 3.6 0.47 10.3 2.5 2.6 2 0 0 2 2 2 0 Anti-repressor SinI DUF1656 PF07869.12 EEA21634.1 - 0.23 11.5 0.6 0.45 10.5 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) Lactamase_B_2 PF12706.7 EEA21635.1 - 2.5e-07 30.4 0.0 5.4e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DRMBL PF07522.14 EEA21635.1 - 2.2e-06 27.8 0.1 8.4e-06 25.9 0.1 2.0 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B PF00753.27 EEA21635.1 - 0.00011 22.3 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 EEA21635.1 - 0.027 14.4 0.0 0.066 13.2 0.0 1.6 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain FRG1 PF06229.12 EEA21636.1 - 4.3e-53 179.9 3.4 4.3e-53 179.9 3.4 2.2 2 1 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 EEA21636.1 - 0.07 13.4 0.0 0.22 11.8 0.0 1.9 2 0 0 2 2 2 0 Fascin domain ABA_WDS PF02496.16 EEA21636.1 - 0.16 12.5 0.0 0.16 12.5 0.0 3.0 3 1 0 3 3 3 0 ABA/WDS induced protein ADH_N PF08240.12 EEA21637.1 - 1.1e-35 121.8 3.3 2.7e-35 120.5 1.9 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA21637.1 - 2.9e-15 56.4 0.0 4.7e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA21637.1 - 2.1e-12 47.0 0.0 3.3e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EEA21637.1 - 2.3e-07 31.9 0.0 3.8e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 EEA21637.1 - 0.0084 15.4 0.1 0.014 14.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NADH_4Fe-4S PF10589.9 EEA21637.1 - 0.1 12.7 0.2 0.32 11.1 0.2 1.9 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Sacchrp_dh_NADP PF03435.18 EEA21637.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF2318 PF10080.9 EEA21637.1 - 0.17 12.0 0.8 10 6.3 0.2 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) SLT PF01464.20 EEA21638.1 - 0.055 13.1 0.1 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 Transglycosylase SLT domain HECT PF00632.25 EEA21639.1 - 1e-75 255.1 0.0 1.4e-75 254.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ITAM_Cys-rich PF10538.9 EEA21639.1 - 0.11 12.3 0.3 0.28 11.0 0.3 1.7 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif Ribosomal_L15e PF00827.17 EEA21640.1 - 4.9e-88 293.9 10.6 6e-88 293.6 10.6 1.0 1 0 0 1 1 1 1 Ribosomal L15 PSP1 PF04468.12 EEA21641.1 - 1.4e-27 95.8 2.7 2.5e-27 95.0 2.7 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region PSP1 PF04468.12 EEA21642.1 - 1.4e-27 95.8 2.7 2.5e-27 95.0 2.7 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Nfu_N PF08712.11 EEA21643.1 - 7e-30 102.9 0.1 4e-29 100.5 0.0 2.2 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EEA21643.1 - 1.1e-27 95.9 0.1 1.9e-27 95.2 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 EEA21644.1 - 1.1e-29 102.3 0.1 3.2e-29 100.8 0.0 1.8 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EEA21644.1 - 8.7e-26 89.9 0.0 1.5e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain zf-HIT PF04438.16 EEA21645.1 - 2.4e-08 33.7 10.1 4e-08 33.0 10.1 1.4 1 0 0 1 1 1 1 HIT zinc finger RasGEF PF00617.19 EEA21646.1 - 1.3e-42 146.0 0.1 2.6e-42 145.0 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EEA21646.1 - 4.8e-15 55.7 0.0 1.2e-14 54.4 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Complex1_LYR_2 PF13233.6 EEA21647.1 - 5.1e-22 78.4 0.9 5.1e-22 78.4 0.9 1.4 2 0 0 2 2 2 1 Complex1_LYR-like Complex1_LYR PF05347.15 EEA21647.1 - 3.7e-05 23.7 2.0 6.5e-05 22.9 2.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Sigma_1s PF02454.16 EEA21647.1 - 0.058 13.4 0.2 0.08 12.9 0.2 1.3 1 0 0 1 1 1 0 Sigma 1s protein CHD5 PF04420.14 EEA21647.1 - 0.1 12.5 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 CHD5-like protein ATP_bind_3 PF01171.20 EEA21648.1 - 2.8e-20 72.9 0.0 1.1e-19 71.0 0.0 1.8 2 0 0 2 2 2 1 PP-loop family zn-ribbon_14 PF16503.5 EEA21648.1 - 4.4e-19 67.7 14.6 8.7e-19 66.7 3.3 3.7 4 0 0 4 4 4 2 Zinc-ribbon RecR PF02132.15 EEA21648.1 - 0.0094 15.5 1.4 0.0094 15.5 1.4 2.6 3 0 0 3 3 3 1 RecR protein tRNA_Me_trans PF03054.16 EEA21648.1 - 0.017 13.9 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase zf-UBR PF02207.20 EEA21648.1 - 1.2 9.3 5.8 11 6.3 0.5 2.6 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) RNHCP PF12647.7 EEA21648.1 - 3.6 7.6 7.6 2.6 8.1 0.6 2.7 3 0 0 3 3 3 0 RNHCP domain ERG2_Sigma1R PF04622.12 EEA21649.1 - 1.9e-99 331.2 0.3 2.3e-99 331.0 0.3 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Cyclin_N PF00134.23 EEA21650.1 - 2.7e-11 43.3 0.0 6.5e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EEA21650.1 - 1.7e-06 28.5 0.0 4.6e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Cyclin DASH_Spc34 PF08657.10 EEA21650.1 - 0.12 12.2 1.0 0.19 11.5 1.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Spc34 Acetyltransf_8 PF13523.6 EEA21651.1 - 1.8e-46 157.4 0.0 2.8e-46 156.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain OCD_Mu_crystall PF02423.15 EEA21652.1 - 3.3e-15 55.8 0.0 6.3e-14 51.6 0.0 2.6 2 1 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EEA21652.1 - 8.8e-07 29.1 0.0 5.5e-05 23.2 0.0 2.7 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Herpes_LMP2 PF07415.11 EEA21652.1 - 0.052 12.3 0.7 0.079 11.7 0.7 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein DUF1992 PF09350.10 EEA21654.1 - 3.9e-23 81.4 0.2 8.8e-23 80.3 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) Cmc1 PF08583.10 EEA21655.1 - 0.053 13.5 0.2 0.067 13.2 0.2 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like His_Phos_1 PF00300.22 EEA21656.1 - 3.9e-35 121.3 0.0 5.1e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.22 EEA21657.1 - 1.5e-33 116.1 0.0 1.8e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) p450 PF00067.22 EEA21658.1 - 5.8e-46 157.2 0.0 8.3e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 EEA21659.1 - 1e-05 25.3 0.1 1e-05 25.3 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EEA21659.1 - 0.00055 19.8 0.0 0.0015 18.3 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EEA21659.1 - 0.03 14.2 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 F-box SRP40_C PF05022.12 EEA21660.1 - 5.4e-16 59.2 0.2 5.4e-16 59.2 0.2 2.5 3 0 0 3 3 3 1 SRP40, C-terminal domain Sec3_C PF09763.9 EEA21661.1 - 6.9e-220 732.1 5.5 9e-220 731.7 5.5 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EEA21661.1 - 7.8e-27 93.2 0.5 1.8e-26 92.1 0.5 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C_2 PF15278.6 EEA21661.1 - 0.0065 16.8 0.7 0.026 14.8 0.1 2.4 2 0 0 2 2 2 1 Sec3 exocyst complex subunit Antimicrobial_7 PF08102.11 EEA21661.1 - 0.18 12.1 0.1 7 7.0 0.1 2.9 2 0 0 2 2 2 0 Scorpion antimicrobial peptide DOCK_N PF16172.5 EEA21662.1 - 2e-111 372.6 0.0 3.6e-111 371.7 0.0 1.5 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 EEA21662.1 - 1.3e-42 146.1 4.7 2.5e-42 145.2 4.7 1.4 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EEA21662.1 - 2.6e-38 131.8 0.0 5e-38 130.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 EEA21662.1 - 5.1e-05 23.1 0.0 0.00047 20.0 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EEA21662.1 - 0.00013 21.5 0.0 0.00026 20.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Phage_AlpA PF05930.12 EEA21662.1 - 0.087 12.7 0.0 6.4 6.7 0.0 2.6 2 0 0 2 2 2 0 Prophage CP4-57 regulatory protein (AlpA) Metallophos PF00149.28 EEA21663.1 - 5.5e-11 43.3 0.2 8.1e-11 42.8 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA21663.1 - 1.1e-07 32.2 2.4 4.5e-06 27.0 2.3 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain R2K_3 PF14243.6 EEA21663.1 - 0.047 13.7 0.0 0.073 13.1 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Ribosomal_S8e PF01201.22 EEA21664.1 - 2.1e-53 180.2 0.8 2.3e-53 180.0 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e DUF2470 PF10615.9 EEA21665.1 - 1.3e-19 70.6 0.1 1.9e-19 70.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) SPX PF03105.19 EEA21666.1 - 2.7e-36 126.3 0.7 4.5e-23 82.8 0.0 2.5 2 1 1 3 3 3 2 SPX domain Na_sulph_symp PF00939.19 EEA21666.1 - 5.2e-27 95.0 45.4 8.1e-27 94.4 45.4 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EEA21666.1 - 6.4e-24 84.7 40.6 1.6e-23 83.3 40.6 1.8 1 0 0 1 1 1 1 Citrate transporter Cytochrome-c551 PF10643.9 EEA21666.1 - 0.016 14.8 0.3 0.062 12.9 0.3 2.0 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 PBP1_TM PF14812.6 EEA21666.1 - 0.92 9.9 4.6 7.7 7.0 5.7 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_S7 PF00177.21 EEA21667.1 - 2.3e-30 105.2 0.0 4.4e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Na_Ca_ex PF01699.24 EEA21668.1 - 3e-42 144.1 40.0 3.9e-21 75.6 18.2 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Glyco_hydro81C PF17652.1 EEA21669.1 - 1.4e-164 547.5 5.3 1.8e-164 547.0 5.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EEA21669.1 - 5.1e-112 374.2 0.0 7.3e-112 373.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Utp14 PF04615.13 EEA21670.1 - 4.4e-217 723.3 67.7 4.4e-217 723.3 67.7 2.0 1 1 1 2 2 2 1 Utp14 protein MRP-L27 PF09809.9 EEA21671.1 - 1.9e-13 50.2 0.2 3.3e-13 49.4 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 HECT PF00632.25 EEA21672.1 - 7.7e-84 281.8 0.0 1.2e-83 281.2 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EEA21672.1 - 0.0034 17.0 1.1 0.014 15.1 1.1 2.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif RRM_1 PF00076.22 EEA21673.1 - 6e-81 266.3 6.6 2.2e-21 75.4 0.2 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EEA21673.1 - 1.7e-29 101.8 0.7 1.2e-28 99.0 0.9 2.3 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EEA21673.1 - 2.2e-15 56.4 0.2 0.0018 17.9 0.0 5.2 2 1 3 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA21673.1 - 0.00014 21.9 2.0 6.4 7.0 0.0 5.4 4 2 0 4 4 4 1 RNA recognition motif CbiG_mid PF11761.8 EEA21673.1 - 0.00049 20.2 0.0 3.3 7.9 0.0 3.5 3 0 0 3 3 3 1 Cobalamin biosynthesis central region Nup35_RRM_2 PF14605.6 EEA21673.1 - 0.00064 19.7 1.1 14 5.8 0.0 4.5 4 1 0 4 4 4 1 Nup53/35/40-type RNA recognition motif YflT PF11181.8 EEA21673.1 - 0.0013 19.2 2.1 0.14 12.7 1.0 2.9 2 0 0 2 2 2 1 Heat induced stress protein YflT Limkain-b1 PF11608.8 EEA21673.1 - 0.016 15.2 2.3 8.4 6.5 0.1 3.6 3 0 0 3 3 3 0 Limkain b1 RRM_occluded PF16842.5 EEA21673.1 - 0.027 14.3 0.0 21 5.1 0.0 3.2 3 0 0 3 3 3 0 Occluded RNA-recognition motif OB_RNB PF08206.11 EEA21673.1 - 0.18 11.5 3.5 15 5.3 0.0 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain CSD PF00313.22 EEA21673.1 - 0.38 10.6 3.4 63 3.5 0.1 3.5 3 0 0 3 3 3 0 'Cold-shock' DNA-binding domain DUF4834 PF16118.5 EEA21673.1 - 1.3 10.1 5.1 0.5 11.3 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DAO PF01266.24 EEA21674.1 - 9.5e-64 216.2 0.2 1.1e-63 216.0 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA21674.1 - 1.7e-05 25.0 0.2 4e-05 23.7 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA21674.1 - 0.0011 18.1 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA21674.1 - 0.0093 15.2 0.0 0.058 12.6 0.0 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA21674.1 - 0.01 15.2 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA21674.1 - 0.044 14.3 0.1 0.36 11.4 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA21674.1 - 0.046 13.0 0.2 0.2 10.8 0.1 1.8 2 0 0 2 2 2 0 FAD binding domain HTH_17 PF12728.7 EEA21674.1 - 0.093 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain AlaDh_PNT_C PF01262.21 EEA21674.1 - 0.13 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EEA21674.1 - 0.16 11.2 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EEA21674.1 - 0.17 11.1 0.7 0.34 10.1 0.3 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 EEA21675.1 - 9.3e-13 47.8 0.5 2.6e-12 46.4 0.5 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA21675.1 - 1.9e-06 28.0 14.4 0.0081 16.6 2.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA21675.1 - 3.4e-06 27.2 8.8 3.4e-06 27.2 8.8 3.7 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA21675.1 - 3.6e-05 24.2 11.9 0.022 15.6 1.3 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA21675.1 - 0.0001 22.5 12.1 0.024 14.9 4.2 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EEA21675.1 - 0.00024 21.4 12.1 0.033 14.6 1.5 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type EutH PF04346.12 EEA21675.1 - 0.039 13.1 0.3 0.062 12.5 0.3 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation protein, EutH zf-C2HC_2 PF13913.6 EEA21675.1 - 0.051 13.5 7.1 0.24 11.3 1.6 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type SSP160 PF06933.11 EEA21675.1 - 0.15 10.2 11.9 0.3 9.2 11.9 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PHD_4 PF16866.5 EEA21675.1 - 0.21 11.7 1.3 0.68 10.1 1.3 1.8 1 0 0 1 1 1 0 PHD-finger zf-C2H2_6 PF13912.6 EEA21675.1 - 0.47 10.5 7.2 0.12 12.4 1.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Dicty_REP PF05086.12 EEA21675.1 - 3.5 5.5 3.5 4.7 5.0 3.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein C1_4 PF07975.12 EEA21675.1 - 4.2 7.7 7.0 7.7 6.8 3.7 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain HgmA PF04209.13 EEA21676.1 - 2.2e-136 455.0 0.0 2.6e-136 454.7 0.0 1.1 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Lyase_1 PF00206.20 EEA21677.1 - 2.5e-48 165.1 0.0 5.4e-48 164.0 0.0 1.5 1 1 0 1 1 1 1 Lyase ADSL_C PF10397.9 EEA21677.1 - 1e-21 77.3 0.0 4.9e-20 71.9 0.0 2.8 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus ASL_C PF08328.11 EEA21677.1 - 0.0049 17.0 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal Thiolase_N PF00108.23 EEA21678.1 - 4.9e-73 245.7 0.1 1.1e-72 244.6 0.0 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA21678.1 - 1.1e-41 141.3 0.0 2.2e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EEA21678.1 - 0.003 17.2 0.0 0.011 15.3 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Prolactin_RP PF15172.6 EEA21678.1 - 0.11 12.1 2.2 1.3 8.7 0.0 2.8 3 0 0 3 3 3 0 Prolactin-releasing peptide CoA_trans PF01144.23 EEA21679.1 - 8e-92 306.5 0.3 2.7e-54 183.8 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase CoA_transf_3 PF02515.17 EEA21680.1 - 3.4e-108 362.1 0.0 4.9e-108 361.5 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III FAD_binding_4 PF01565.23 EEA21680.1 - 7.3e-27 93.8 0.0 1.3e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EEA21680.1 - 5.1e-16 59.0 0.0 8.7e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain Fungal_trans PF04082.18 EEA21682.1 - 1.3e-21 76.8 0.2 2e-21 76.2 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain IBN_N PF03810.19 EEA21682.1 - 0.075 13.0 0.0 0.44 10.5 0.0 2.2 3 0 0 3 3 3 0 Importin-beta N-terminal domain Vps52 PF04129.12 EEA21683.1 - 7.5e-120 401.1 0.0 9.3e-120 400.7 0.0 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EEA21683.1 - 0.00053 18.5 3.5 0.0014 17.1 3.6 1.5 1 1 0 1 1 1 1 Exocyst complex component Sec3 MitMem_reg PF13012.6 EEA21683.1 - 0.074 13.5 1.2 8 6.9 1.2 2.9 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function Laminin_II PF06009.12 EEA21683.1 - 0.13 12.3 1.4 0.48 10.4 0.1 2.2 2 0 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 EEA21683.1 - 0.15 11.0 1.3 0.32 9.8 0.3 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Exo70 PF03081.15 EEA21683.1 - 1.7 7.6 5.1 1.7 7.6 0.0 2.9 3 1 1 4 4 4 0 Exo70 exocyst complex subunit eIF-5a PF01287.20 EEA21684.1 - 1.1e-27 95.9 1.5 1.6e-27 95.4 1.5 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EEA21684.1 - 0.0048 16.9 0.1 0.01 15.8 0.0 1.6 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain eIF-5a PF01287.20 EEA21685.1 - 7.9e-28 96.4 1.5 1.1e-27 95.9 1.5 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EEA21685.1 - 0.0048 16.9 0.0 0.0076 16.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain zf-RRN7 PF11781.8 EEA21686.1 - 9.3e-08 31.6 4.6 1.5e-07 31.0 4.6 1.3 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ubiquitin PF00240.23 EEA21687.1 - 3.7e-34 116.3 0.6 4.9e-34 115.9 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EEA21687.1 - 9.2e-31 105.5 11.4 1.4e-30 104.9 11.4 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EEA21687.1 - 3e-16 59.0 0.7 3e-16 59.0 0.7 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA21687.1 - 2e-05 24.9 0.1 7.4e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EEA21687.1 - 0.0037 17.6 0.0 0.0055 17.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EEA21687.1 - 0.0039 17.1 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA21687.1 - 0.0057 16.7 0.0 0.012 15.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EEA21687.1 - 0.014 15.4 1.0 4.2 7.5 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EEA21687.1 - 0.026 15.1 0.1 0.032 14.8 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EEA21687.1 - 0.08 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Yip1 PF04893.17 EEA21688.1 - 1.1e-14 54.5 13.3 1.8e-14 53.8 13.4 1.4 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 EEA21688.1 - 0.044 13.3 2.2 0.064 12.8 1.5 1.7 1 1 0 1 1 1 0 YIF1 RabGAP-TBC PF00566.18 EEA21689.1 - 2.8e-22 79.4 0.0 5e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 EEA21690.1 - 1.3e-79 262.9 19.1 1.9e-12 47.6 0.2 16.4 9 5 9 18 18 18 15 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA21690.1 - 1e-70 233.2 30.9 1.1e-06 29.1 0.0 22.9 17 6 7 24 24 24 17 Ankyrin repeats (many copies) Ank PF00023.30 EEA21690.1 - 4.1e-58 191.4 43.3 7.1e-07 29.4 0.0 22.1 22 2 0 22 22 22 14 Ankyrin repeat Ank_5 PF13857.6 EEA21690.1 - 7.6e-58 191.8 34.1 5e-09 36.2 0.0 19.7 17 4 4 21 21 21 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA21690.1 - 1.5e-47 154.0 38.7 1.5e-05 25.0 0.0 25.4 29 1 0 29 29 29 8 Ankyrin repeat NACHT PF05729.12 EEA21690.1 - 0.0028 17.6 0.6 0.014 15.3 0.1 2.3 2 0 0 2 2 2 1 NACHT domain Peptidase_M20 PF01546.28 EEA21691.1 - 1.7e-32 112.8 0.1 3e-32 112.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA21691.1 - 7.8e-05 22.6 0.0 0.00021 21.2 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EEA21691.1 - 0.0002 21.1 0.0 0.00035 20.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 DUF4735 PF15882.5 EEA21691.1 - 0.023 14.2 0.5 0.041 13.3 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4735) Aldedh PF00171.22 EEA21692.1 - 5.2e-142 473.6 0.0 6.4e-142 473.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA21692.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) ADH_N PF08240.12 EEA21693.1 - 3e-24 85.0 0.2 5.6e-24 84.1 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA21693.1 - 2.7e-21 75.9 0.6 3.9e-21 75.4 0.6 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA21693.1 - 0.0008 20.5 0.2 0.0021 19.1 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA21693.1 - 0.002 17.6 0.2 0.0032 17.0 0.2 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus adh_short PF00106.25 EEA21693.1 - 0.055 12.9 0.2 0.13 11.7 0.2 1.7 1 0 0 1 1 1 0 short chain dehydrogenase SAM_MT PF04445.13 EEA21693.1 - 0.18 11.2 1.3 0.44 9.9 0.1 1.9 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase Transp_cyt_pur PF02133.15 EEA21694.1 - 5.6e-36 124.3 33.8 7.9e-36 123.8 33.8 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DDE_3 PF13358.6 EEA21695.1 - 6.9e-18 64.8 0.1 1.2e-17 64.0 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 EEA21695.1 - 4.5e-08 33.6 6.9 2.5e-05 24.8 0.5 2.5 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 EEA21695.1 - 0.0033 17.6 0.2 0.022 15.0 0.0 2.3 2 0 0 2 2 2 1 Transposase MMS1_N PF10433.9 EEA21696.1 - 2e-94 316.9 0.0 3.8e-94 316.1 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EEA21696.1 - 4.7e-07 29.4 0.0 1.4e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 CPSF A subunit region Tricorn_PDZ PF14685.6 EEA21696.1 - 0.11 12.5 0.1 5.6 7.0 0.0 3.0 3 0 0 3 3 3 0 Tricorn protease PDZ domain PQQ_3 PF13570.6 EEA21696.1 - 5.3 7.7 9.4 30 5.3 0.0 5.5 6 0 0 6 6 6 0 PQQ-like domain MCM PF00493.23 EEA21697.1 - 2.5e-94 314.6 0.0 4.6e-94 313.7 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA21697.1 - 1.5e-30 105.6 0.0 2.7e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA21697.1 - 7.6e-25 87.2 0.8 1.5e-24 86.2 0.8 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA21697.1 - 9.4e-12 45.4 0.0 3.4e-11 43.7 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EEA21697.1 - 1.4e-06 27.9 0.0 1.6e-05 24.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EEA21697.1 - 0.0031 17.4 0.0 0.0074 16.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA21697.1 - 0.027 14.5 0.0 0.25 11.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EEA21697.1 - 0.1 12.3 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain TFIIF_alpha PF05793.12 EEA21697.1 - 2.7 6.5 11.6 4 5.9 11.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PPR_2 PF13041.6 EEA21698.1 - 2.2e-22 79.0 0.2 1.4e-12 47.6 0.0 7.8 7 1 2 9 9 9 3 PPR repeat family PPR PF01535.20 EEA21698.1 - 1.7e-16 59.2 7.8 1.8e-05 24.6 0.0 9.7 11 0 0 11 11 11 4 PPR repeat PPR_3 PF13812.6 EEA21698.1 - 2.9e-15 56.1 0.0 2.3e-06 27.6 0.0 5.0 5 0 0 5 5 5 3 Pentatricopeptide repeat domain PPR_long PF17177.4 EEA21698.1 - 2.7e-07 30.2 0.0 0.063 12.6 0.0 4.0 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EEA21698.1 - 3.9e-07 29.6 0.3 0.78 9.5 0.0 4.7 5 0 0 5 5 5 3 PPR repeat TPR_14 PF13428.6 EEA21698.1 - 0.0046 17.7 3.7 4.7 8.3 0.0 5.6 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA21698.1 - 0.028 14.3 0.2 0.15 11.9 0.2 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat SHQ1 PF04925.15 EEA21698.1 - 0.12 12.0 1.0 0.23 11.0 0.2 1.8 2 0 0 2 2 2 0 SHQ1 protein SRP68 PF16969.5 EEA21699.1 - 9.2e-190 632.3 0.5 1e-189 632.2 0.5 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 BRO1 PF03097.18 EEA21699.1 - 0.0052 15.6 0.0 0.01 14.7 0.0 1.4 1 0 0 1 1 1 1 BRO1-like domain SRP68 PF16969.5 EEA21700.1 - 2.5e-156 522.0 0.1 3e-156 521.7 0.1 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 BRO1 PF03097.18 EEA21700.1 - 0.0042 15.9 0.0 0.0077 15.1 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain p450 PF00067.22 EEA21701.1 - 1.3e-53 182.4 0.0 2.7e-53 181.4 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Rhodanese PF00581.20 EEA21702.1 - 3.5e-13 50.0 0.0 7.7e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain GTP_EFTU PF00009.27 EEA21703.1 - 3.5e-33 114.8 1.6 8.9e-33 113.5 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EEA21703.1 - 9.2e-20 70.7 0.0 3.9e-19 68.7 0.0 2.1 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EEA21703.1 - 7.5e-11 42.3 10.5 1.5e-09 38.1 0.0 4.0 4 1 0 4 4 4 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EEA21703.1 - 1.4e-09 37.7 0.2 5.2e-09 35.9 0.2 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EEA21703.1 - 7.4e-07 29.3 0.2 7.9e-06 25.9 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EEA21703.1 - 0.00068 19.9 0.0 0.0019 18.4 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EEA21703.1 - 0.0078 16.0 0.0 0.035 13.9 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EEA21703.1 - 0.074 13.0 0.5 1.2 9.0 0.4 3.0 2 1 0 2 2 2 0 RsgA GTPase Spo7 PF03907.13 EEA21704.1 - 5e-87 291.0 0.2 5e-87 291.0 0.2 1.4 2 0 0 2 2 2 1 Spo7-like protein DUF1772 PF08592.11 EEA21704.1 - 0.045 14.1 0.1 15 5.9 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) Edc3_linker PF16598.5 EEA21704.1 - 5 7.9 10.1 7.5 7.3 9.0 1.8 1 1 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 Abhydrolase_1 PF00561.20 EEA21705.1 - 1.1e-21 77.6 0.0 4.3e-20 72.4 0.0 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA21705.1 - 2.6e-17 62.9 0.0 3.1e-16 59.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA21705.1 - 3e-17 63.9 6.6 3.4e-16 60.5 6.6 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 EEA21705.1 - 4.1e-06 26.3 0.0 8.9e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 EEA21705.1 - 4.5e-05 23.2 0.0 0.0001 22.0 0.0 1.6 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 EEA21705.1 - 0.0014 18.6 0.0 0.0034 17.3 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EEA21705.1 - 0.0018 17.2 0.0 0.0028 16.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme LIDHydrolase PF10230.9 EEA21705.1 - 0.0026 17.4 0.0 0.0063 16.1 0.0 1.6 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 EEA21705.1 - 0.0073 16.1 0.0 0.026 14.3 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Ndr PF03096.14 EEA21705.1 - 0.0083 14.9 0.0 0.013 14.2 0.0 1.2 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 EEA21705.1 - 0.009 16.1 0.7 0.077 13.1 0.7 2.4 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EEA21705.1 - 0.018 14.8 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 PGAP1-like protein Chlorophyllase PF07224.11 EEA21705.1 - 0.024 13.7 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_2 PF02230.16 EEA21705.1 - 0.033 14.0 0.0 2.8 7.7 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase TatD_DNase PF01026.21 EEA21707.1 - 1.7e-33 116.1 0.0 3.6e-33 115.0 0.0 1.5 1 1 0 1 1 1 1 TatD related DNase Fungal_trans PF04082.18 EEA21708.1 - 3.1e-20 72.3 0.0 4.7e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain YL1 PF05764.13 EEA21709.1 - 1.5e-05 25.2 7.8 1.9e-05 24.9 7.8 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 EEA21709.1 - 0.0016 16.8 6.5 0.0016 16.8 6.5 1.1 1 0 0 1 1 1 1 CDC45-like protein Rrn6 PF10214.9 EEA21709.1 - 0.03 12.8 3.6 0.034 12.6 3.6 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Nop14 PF04147.12 EEA21709.1 - 0.19 9.9 6.6 0.19 9.9 6.6 1.1 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 EEA21709.1 - 0.19 11.7 3.8 0.31 11.1 3.8 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Sporozoite_P67 PF05642.11 EEA21709.1 - 0.23 9.5 3.5 0.23 9.5 3.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TLP-20 PF06088.11 EEA21709.1 - 0.26 11.2 2.9 0.35 10.7 2.9 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DNA_pol_phi PF04931.13 EEA21709.1 - 9.2 4.2 13.2 11 3.9 13.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Fungal_trans PF04082.18 EEA21710.1 - 5.4e-19 68.3 0.1 1.2e-18 67.1 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21710.1 - 4.7e-10 39.4 12.0 7.8e-10 38.7 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Asp PF00026.23 EEA21711.1 - 6e-55 186.9 2.8 7.1e-55 186.6 2.8 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA21711.1 - 4.5e-05 23.7 0.2 0.00093 19.5 0.1 2.8 2 1 1 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA21711.1 - 0.0013 19.4 0.0 2.6 8.7 0.0 2.6 2 0 0 2 2 2 2 Aspartyl protease CBFD_NFYB_HMF PF00808.23 EEA21712.1 - 2.4e-29 101.4 1.2 3.2e-29 101.0 1.2 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA21712.1 - 4.3e-06 27.1 0.0 7.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 EEA21712.1 - 0.0012 18.8 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 EEA21712.1 - 0.0016 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 EEA21712.1 - 0.0029 17.7 0.0 0.0039 17.3 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 EEA21712.1 - 0.047 14.2 0.0 0.088 13.3 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Prefoldin_2 PF01920.20 EEA21713.1 - 3.7e-24 84.7 7.4 4.5e-24 84.4 7.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EEA21713.1 - 0.0058 16.5 3.0 0.44 10.5 0.1 2.2 1 1 1 2 2 2 2 Prefoldin subunit ATPase PF06745.13 EEA21713.1 - 0.047 13.0 1.2 3 7.1 0.2 2.0 1 1 1 2 2 2 0 KaiC DUF4376 PF14301.6 EEA21713.1 - 0.078 13.4 3.0 6.4 7.2 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4376) CC2-LZ PF16516.5 EEA21713.1 - 0.082 13.3 7.3 1.2 9.6 2.6 2.1 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator MCR_beta PF02241.18 EEA21713.1 - 0.098 12.2 0.2 0.11 12.1 0.2 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain DUF3450 PF11932.8 EEA21713.1 - 0.61 9.3 9.5 1.4 8.2 4.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) APH PF01636.23 EEA21714.1 - 8.7e-15 55.3 0.1 1.2e-14 54.8 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EEA21714.1 - 0.053 12.4 0.0 0.79 8.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EEA21714.1 - 0.12 11.9 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase EcKinase PF02958.20 EEA21714.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase DUF4611 PF15387.6 EEA21714.1 - 0.46 10.7 5.9 2.2 8.6 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) HA2 PF04408.23 EEA21715.1 - 3.9e-21 75.4 1.8 1.3e-20 73.6 0.0 2.7 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA21715.1 - 3.4e-17 62.6 0.0 9.5e-17 61.1 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA21715.1 - 1.8e-15 57.2 0.0 4.2e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA21715.1 - 2.2e-06 27.6 0.0 5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA21715.1 - 0.0001 22.6 0.1 0.00031 21.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EEA21715.1 - 0.0019 17.3 0.0 0.0041 16.2 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 EEA21715.1 - 0.0019 17.9 0.3 0.0057 16.3 0.3 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 EEA21715.1 - 0.0022 17.7 0.0 0.0052 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EEA21715.1 - 0.0025 17.2 0.0 0.0048 16.3 0.0 1.4 1 0 0 1 1 1 1 KaiC DUF2075 PF09848.9 EEA21715.1 - 0.0033 16.7 0.0 0.006 15.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EEA21715.1 - 0.0061 16.9 0.2 0.028 14.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EEA21715.1 - 0.02 14.9 0.0 8.8 6.3 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EEA21715.1 - 0.026 14.5 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain NACHT PF05729.12 EEA21715.1 - 0.046 13.6 1.6 0.31 11.0 0.7 2.6 2 1 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 EEA21715.1 - 0.048 13.7 0.2 0.25 11.4 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EEA21715.1 - 0.075 13.2 0.4 0.6 10.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EEA21715.1 - 0.11 13.0 0.1 0.34 11.4 0.0 1.9 2 0 0 2 2 1 0 ABC transporter AAA_24 PF13479.6 EEA21715.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA21715.1 - 0.15 12.4 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain DAD PF02109.16 EEA21716.1 - 5.8e-46 155.3 4.1 2.2e-45 153.5 4.1 1.8 1 1 0 1 1 1 1 DAD family Mucin PF01456.17 EEA21716.1 - 0.13 12.3 15.6 7.6 6.5 0.0 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein Lin-8 PF03353.15 EEA21716.1 - 0.62 9.6 1.9 0.63 9.5 0.2 1.7 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MGC-24 PF05283.11 EEA21716.1 - 3.6 8.0 15.4 19 5.7 10.4 2.4 2 1 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Fungal_trans PF04082.18 EEA21717.1 - 2.3e-17 62.9 0.1 2.3e-17 62.9 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21717.1 - 7.2e-10 38.8 9.5 1.4e-09 37.9 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LicD PF04991.13 EEA21718.1 - 4.2e-23 82.7 4.0 7.1e-16 59.0 2.0 2.3 1 1 1 2 2 2 2 LicD family Fungal_trans PF04082.18 EEA21719.1 - 0.0016 17.5 0.0 0.0033 16.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21719.1 - 0.0025 17.9 11.8 0.0025 17.9 11.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAM219A PF15260.6 EEA21720.1 - 0.037 14.4 2.2 0.037 14.4 0.2 2.0 2 0 0 2 2 2 0 Protein family FAM219A Baculo_PEP_C PF04513.12 EEA21720.1 - 0.41 10.7 4.7 0.24 11.4 1.0 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus GFO_IDH_MocA PF01408.22 EEA21721.1 - 9.5e-19 68.4 0.0 2e-18 67.3 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold BCA_ABC_TP_C PF12399.8 EEA21721.1 - 0.046 13.7 0.1 0.094 12.7 0.1 1.6 1 0 0 1 1 1 0 Branched-chain amino acid ATP-binding cassette transporter Transp_cyt_pur PF02133.15 EEA21722.1 - 7.9e-89 298.4 40.1 1.1e-88 298.0 40.1 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF726 PF05277.12 EEA21723.1 - 3.1e-126 421.0 2.9 4.2e-126 420.5 2.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) FliT PF05400.13 EEA21723.1 - 4.6 8.1 6.0 14 6.6 1.0 3.0 2 0 0 2 2 2 0 Flagellar protein FliT DDE_1 PF03184.19 EEA21724.1 - 3.5e-13 49.6 0.1 1.1e-12 48.0 0.0 1.9 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA21724.1 - 5e-05 23.2 2.8 0.00012 22.0 0.0 2.8 3 1 0 3 3 3 1 Tc5 transposase DNA-binding domain Med9 PF07544.13 EEA21724.1 - 7.1 6.8 10.0 0.27 11.3 3.7 1.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 RTC4 PF14474.6 EEA21725.1 - 1.6e-29 102.5 0.0 3.8e-29 101.3 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain U79_P34 PF03064.16 EEA21725.1 - 2.1 7.7 11.8 3.5 6.9 11.8 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 TFR_dimer PF04253.15 EEA21726.1 - 4e-31 107.6 0.0 6.6e-31 106.9 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EEA21726.1 - 3e-20 72.8 0.0 5.8e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EEA21726.1 - 9.7e-12 44.8 0.9 6.6e-11 42.1 0.9 2.2 1 1 0 1 1 1 1 PA domain Nicastrin PF05450.15 EEA21726.1 - 0.049 13.1 0.0 0.089 12.2 0.0 1.3 1 0 0 1 1 1 0 Nicastrin MFS_1 PF07690.16 EEA21727.1 - 4.5e-31 108.0 17.2 4.5e-31 108.0 17.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Tmemb_14 PF03647.13 EEA21728.1 - 1.7e-20 73.6 8.1 2e-20 73.3 8.1 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C zf-C2H2_4 PF13894.6 EEA21729.1 - 7.5e-07 29.5 2.0 0.0078 17.0 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA21729.1 - 0.00031 21.0 2.8 0.012 16.0 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type Rrn6 PF10214.9 EEA21730.1 - 0.0012 17.5 9.2 0.0012 17.5 9.2 2.5 2 1 0 2 2 2 2 RNA polymerase I-specific transcription-initiation factor Patched PF02460.18 EEA21731.1 - 0.19 9.8 0.0 0.19 9.8 0.0 1.0 1 0 0 1 1 1 0 Patched family DUF5427 PF10310.9 EEA21732.1 - 1.5e-164 548.4 1.1 7.1e-164 546.2 1.1 1.8 1 1 0 1 1 1 1 Family of unknown function (DUF5427) Flu_M1_C PF08289.11 EEA21732.1 - 0.0035 17.5 1.9 0.0099 16.1 0.9 2.1 2 0 0 2 2 2 1 Influenza Matrix protein (M1) C-terminal domain SARAF PF06682.12 EEA21732.1 - 0.71 9.5 2.9 1 8.9 2.9 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CDC27 PF09507.10 EEA21732.1 - 2.2 7.6 11.5 3.5 6.9 11.5 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SurE PF01975.17 EEA21733.1 - 8.1e-53 179.1 0.0 2.8e-52 177.4 0.0 1.8 1 1 0 1 1 1 1 Survival protein SurE Glyco_trans_4_4 PF13579.6 EEA21733.1 - 0.071 13.6 0.5 0.25 11.8 0.0 2.0 2 1 0 2 2 2 0 Glycosyl transferase 4-like domain DUF3439 PF11921.8 EEA21733.1 - 0.13 12.3 5.3 0.21 11.5 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 EEA21733.1 - 1.2 7.3 5.5 1.6 6.9 5.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 EEA21733.1 - 1.4 6.9 2.8 2.1 6.2 2.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Zn_clus PF00172.18 EEA21734.1 - 0.0029 17.7 10.4 0.0054 16.8 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WW_FCH_linker PF16623.5 EEA21734.1 - 0.096 13.4 0.4 0.3 11.8 0.4 1.8 1 0 0 1 1 1 0 Unstructured linker region between on GAS7 protein DUF2462 PF09495.10 EEA21735.1 - 1.2e-16 61.2 8.6 1.2e-16 61.2 8.6 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2462) Golgin_A5 PF09787.9 EEA21736.1 - 8.8e-05 22.1 1.2 0.0002 21.0 1.2 1.6 1 0 0 1 1 1 1 Golgin subfamily A member 5 FlxA PF14282.6 EEA21736.1 - 0.041 13.9 0.4 0.32 11.0 0.0 2.6 2 0 0 2 2 2 0 FlxA-like protein TMF_DNA_bd PF12329.8 EEA21736.1 - 0.11 12.6 1.7 32 4.6 0.5 3.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.7 EEA21736.1 - 0.14 12.3 9.2 0.29 11.3 4.3 2.9 2 1 1 3 3 3 0 Tropomyosin like CEP209_CC5 PF16574.5 EEA21736.1 - 0.58 10.3 4.6 2.8 8.1 4.7 2.0 1 1 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 SSXRD PF09514.10 EEA21736.1 - 1.3 8.7 3.6 1.5 8.5 2.1 2.0 2 0 0 2 2 2 0 SSXRD motif DUF4407 PF14362.6 EEA21736.1 - 3.5 6.9 5.4 6.8 5.9 5.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BBP1_C PF15272.6 EEA21736.1 - 7.8 6.3 7.8 15 5.4 1.5 2.6 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal GPI-anchored PF10342.9 EEA21737.1 - 1.1e-22 80.6 0.3 1.1e-22 80.6 0.3 2.3 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family RTA1 PF04479.13 EEA21738.1 - 4.3e-19 69.0 0.2 4.6e-19 68.8 0.2 1.0 1 0 0 1 1 1 1 RTA1 like protein Fungal_trans PF04082.18 EEA21739.1 - 9.2e-12 44.6 0.5 1.6e-11 43.8 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21739.1 - 1.3e-06 28.4 11.1 2.4e-06 27.5 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4690 PF15756.5 EEA21739.1 - 0.18 12.4 0.5 0.51 11.0 0.0 2.0 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Cu-oxidase_3 PF07732.15 EEA21740.1 - 1.6e-43 147.5 4.7 1.6e-42 144.3 1.1 3.0 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EEA21740.1 - 8.4e-32 110.5 0.0 1.4e-30 106.5 0.0 2.6 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA21740.1 - 5.5e-31 107.1 7.0 3.4e-28 98.1 0.7 3.4 3 1 0 3 3 3 2 Multicopper oxidase LOR PF04525.12 EEA21741.1 - 6e-08 32.5 0.2 8e-08 32.1 0.2 1.2 1 0 0 1 1 1 1 LURP-one-related CdAMP_rec PF06153.11 EEA21741.1 - 0.023 14.9 0.1 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 Cyclic-di-AMP receptor MOSC_N PF03476.16 EEA21741.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 MOSC N-terminal beta barrel domain Peptidase_S24 PF00717.23 EEA21742.1 - 0.0015 18.4 0.0 0.0037 17.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase S24-like Protoglobin PF11563.8 EEA21744.1 - 4e-58 195.8 0.0 4.9e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 Protoglobin Protoglobin PF11563.8 EEA21745.1 - 4e-58 195.8 0.0 4.9e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 Protoglobin DDE_1 PF03184.19 EEA21746.1 - 1.4e-13 50.9 0.0 2.7e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA21746.1 - 8.5e-13 48.1 0.0 5.8e-12 45.5 0.0 2.5 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA21746.1 - 3.8 7.5 7.2 0.52 10.2 1.5 2.5 2 0 0 2 2 2 0 Myb DNA-binding like Cellulase PF00150.18 EEA21747.1 - 1.8e-14 53.9 6.6 5.7e-14 52.2 6.6 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) IBN_N PF03810.19 EEA21748.1 - 4.8e-16 58.4 0.2 4.6e-14 52.1 0.2 3.1 2 0 0 2 2 2 2 Importin-beta N-terminal domain Phosphoesterase PF04185.14 EEA21750.1 - 7e-35 120.9 4.6 2.7e-34 118.9 4.5 1.9 1 1 0 1 1 1 1 Phosphoesterase family HIF-1a_CTAD PF08778.10 EEA21750.1 - 0.074 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain Pex2_Pex12 PF04757.14 EEA21751.1 - 4.4e-39 134.4 2.1 6.1e-39 133.9 2.1 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EEA21751.1 - 0.00026 21.1 5.1 0.00054 20.1 5.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EEA21751.1 - 0.041 13.7 1.6 0.092 12.6 1.6 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA21751.1 - 0.12 12.4 4.0 0.43 10.7 4.0 1.9 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA21751.1 - 0.23 11.4 3.0 0.29 11.0 0.5 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ER_lumen_recept PF00810.18 EEA21753.1 - 3.7e-44 151.1 10.0 6.7e-44 150.3 10.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EEA21753.1 - 0.6 9.9 7.5 1 9.2 0.2 3.5 3 0 0 3 3 3 0 PQ loop repeat Ribosomal_L27A PF00828.19 EEA21754.1 - 3.6e-23 82.6 0.0 5.5e-23 82.0 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RAP PF08373.10 EEA21754.1 - 0.14 12.3 1.0 0.2 11.8 1.0 1.3 1 0 0 1 1 1 0 RAP domain eRF1_1 PF03463.15 EEA21755.1 - 4.6e-45 152.8 0.0 7e-45 152.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EEA21755.1 - 1.5e-20 73.8 0.0 3e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EEA21755.1 - 3.9e-19 69.3 0.0 5.7e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 Ribosomal_S19e PF01090.19 EEA21757.1 - 8.7e-58 193.9 0.2 9.8e-58 193.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Abhydrolase_6 PF12697.7 EEA21758.1 - 8.2e-16 59.3 0.7 1.7e-15 58.2 0.7 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA21758.1 - 2.6e-15 56.8 0.0 9.8e-15 54.9 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA21758.1 - 2.4e-10 40.1 0.0 3.1e-09 36.5 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DSPc PF00782.20 EEA21758.1 - 5.3e-10 39.2 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Ser_hydrolase PF06821.13 EEA21758.1 - 0.00049 20.0 0.6 0.005 16.7 0.1 2.4 2 0 0 2 2 2 1 Serine hydrolase Thioesterase PF00975.20 EEA21758.1 - 0.0057 16.8 0.1 0.0097 16.0 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain Y_phosphatase PF00102.27 EEA21758.1 - 0.0071 15.9 0.0 0.02 14.5 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase FSH1 PF03959.13 EEA21758.1 - 0.014 15.0 0.0 0.18 11.4 0.0 2.1 1 1 0 1 1 1 0 Serine hydrolase (FSH1) PTPlike_phytase PF14566.6 EEA21758.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate LIDHydrolase PF10230.9 EEA21758.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase ILVD_EDD PF00920.21 EEA21759.1 - 2.8e-212 706.0 0.7 3.3e-212 705.7 0.7 1.0 1 0 0 1 1 1 1 Dehydratase family DUF1772 PF08592.11 EEA21760.1 - 9.2e-28 97.3 0.6 1.3e-27 96.7 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) 2OG-FeII_Oxy_3 PF13640.6 EEA21761.1 - 5.3e-09 36.8 0.0 1.1e-08 35.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Aminotran_3 PF00202.21 EEA21763.1 - 2e-44 151.9 1.2 3.5e-43 147.8 1.2 2.0 1 1 0 1 1 1 1 Aminotransferase class-III Protamine_P2 PF00841.19 EEA21764.1 - 0.032 14.7 0.8 0.032 14.7 0.8 3.2 3 1 0 3 3 3 0 Sperm histone P2 Myb_DNA-bind_6 PF13921.6 EEA21765.1 - 1.3e-06 28.6 0.8 0.069 13.4 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA21765.1 - 0.00056 20.0 1.1 0.0014 18.8 0.2 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA21766.1 - 2.7e-15 56.3 3.5 3.3e-09 36.8 0.8 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA21766.1 - 1.1e-09 38.4 3.5 1.1e-05 25.6 0.8 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain TFIIA PF03153.13 EEA21766.1 - 0.011 15.8 12.8 0.012 15.7 12.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 EEA21766.1 - 0.15 10.7 8.0 0.16 10.6 8.0 1.2 1 0 0 1 1 1 0 Hamartin protein Pex14_N PF04695.13 EEA21766.1 - 0.18 12.4 15.5 0.34 11.6 15.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Myb_DNA-bind_7 PF15963.5 EEA21766.1 - 0.51 10.3 4.9 0.068 13.1 0.7 1.8 2 0 0 2 2 2 0 Myb DNA-binding like CCDC14 PF15254.6 EEA21766.1 - 0.87 8.2 7.5 0.88 8.1 7.5 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 Transp_cyt_pur PF02133.15 EEA21767.1 - 5.2e-14 51.9 40.4 1.2e-13 50.7 40.4 1.6 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin COX5B PF01215.19 EEA21768.1 - 1.4e-53 180.0 0.0 1.9e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb NACHT PF05729.12 EEA21769.1 - 1.1e-05 25.4 0.1 3.1e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EEA21769.1 - 0.0004 20.7 0.0 0.023 15.0 0.0 2.9 1 1 1 2 2 2 1 AAA domain SesA PF17107.5 EEA21769.1 - 0.00048 20.3 2.0 0.0056 16.9 0.1 2.6 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases AAA_16 PF13191.6 EEA21769.1 - 0.0012 19.3 0.1 0.0099 16.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EEA21769.1 - 0.0055 17.2 1.6 0.031 14.8 0.0 3.0 3 2 1 4 4 4 1 ABC transporter Ank_2 PF12796.7 EEA21769.1 - 0.024 15.2 0.0 0.07 13.7 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) HSCB_C PF07743.13 EEA21769.1 - 0.031 14.8 0.7 0.2 12.2 0.4 2.7 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain AAA_29 PF13555.6 EEA21769.1 - 0.051 13.3 0.4 0.13 12.0 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EEA21769.1 - 0.17 11.8 0.3 0.45 10.4 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 EEA21769.1 - 0.86 10.1 12.5 0.24 11.9 0.2 3.3 3 1 1 4 4 4 0 AAA domain Baculo_PEP_C PF04513.12 EEA21769.1 - 0.99 9.4 9.8 15 5.6 0.2 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF87 PF01935.17 EEA21769.1 - 5.7 7.0 8.1 2.6 8.1 0.0 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain Myb_DNA-bind_6 PF13921.6 EEA21770.1 - 5.1e-13 49.1 0.0 1.9e-07 31.2 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA21770.1 - 5.1e-11 42.6 0.2 7.1e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain tRNA-synt_1b PF00579.25 EEA21771.1 - 5.8e-21 75.1 0.0 3.7e-20 72.4 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1b PF00579.25 EEA21772.1 - 9.2e-09 35.0 0.0 6.8e-08 32.2 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) PROCN PF08083.11 EEA21773.1 - 5.3e-235 779.6 7.4 5.3e-235 779.6 7.4 1.9 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EEA21773.1 - 4.2e-127 422.5 1.4 7.4e-127 421.7 1.4 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EEA21773.1 - 6.1e-89 296.0 2.0 1.9e-88 294.4 2.0 1.9 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EEA21773.1 - 1.4e-81 271.8 2.0 4.3e-81 270.2 2.0 1.9 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EEA21773.1 - 2.1e-71 238.3 0.1 5.6e-71 236.9 0.1 1.8 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 EEA21773.1 - 2.2e-48 163.2 0.1 6.5e-48 161.7 0.1 1.9 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 EEA21773.1 - 2.8e-48 162.2 0.3 7.7e-48 160.8 0.3 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 Ribosomal_L34e PF01199.18 EEA21774.1 - 9e-43 144.5 2.7 1.3e-42 143.9 2.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L34e Vps36-NZF-N PF16988.5 EEA21774.1 - 0.031 13.7 0.9 0.062 12.7 0.0 2.0 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain FhuF_C PF11575.8 EEA21774.1 - 0.81 9.7 4.9 3.5 7.7 0.3 2.7 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain Ribosomal_L34e PF01199.18 EEA21775.1 - 2.8e-16 59.6 0.1 5e-16 58.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L34e Forkhead PF00250.18 EEA21776.1 - 3.4e-20 72.1 0.3 7e-20 71.1 0.3 1.5 1 0 0 1 1 1 1 Forkhead domain DUF4712 PF15830.5 EEA21776.1 - 0.54 9.9 2.0 1 9.0 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4712) Cactin_mid PF10312.9 EEA21777.1 - 6.8e-64 215.2 5.8 1.3e-63 214.4 5.8 1.5 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EEA21777.1 - 2e-57 192.5 6.6 3.6e-57 191.7 6.6 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein SF3A2 PF16835.5 EEA21777.1 - 0.013 15.9 0.0 0.054 13.9 0.0 2.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) DUF1087 PF06465.13 EEA21777.1 - 0.032 14.2 0.9 0.091 12.8 0.2 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) XLF PF09302.11 EEA21778.1 - 1.4e-43 149.2 0.7 1.4e-43 149.2 0.7 1.8 2 0 0 2 2 2 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component WD40 PF00400.32 EEA21779.1 - 1.6e-15 57.2 10.2 2.1e-06 28.3 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA21779.1 - 2.8e-06 27.5 0.1 1.1 9.6 0.0 4.6 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA21779.1 - 8.3e-06 25.8 0.1 0.0042 17.0 0.0 3.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Zn_ribbon_17 PF17120.5 EEA21779.1 - 0.038 13.6 9.0 0.089 12.4 9.0 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type HSP20 PF00011.21 EEA21779.1 - 0.079 13.1 0.2 0.18 12.0 0.2 1.5 1 0 0 1 1 1 0 Hsp20/alpha crystallin family zf-rbx1 PF12678.7 EEA21779.1 - 3.2 8.1 9.3 0.12 12.7 0.7 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain ABC_membrane PF00664.23 EEA21780.1 - 1.7e-35 123.0 6.9 1.7e-35 123.0 6.9 2.2 3 0 0 3 3 3 1 ABC transporter transmembrane region ABC_tran PF00005.27 EEA21780.1 - 1.6e-33 116.1 0.0 5.9e-33 114.3 0.0 2.0 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EEA21780.1 - 1.3e-07 31.3 1.2 3.2e-06 26.7 0.3 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA21780.1 - 0.0037 17.5 0.1 0.031 14.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EEA21780.1 - 0.024 14.4 1.4 0.1 12.4 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 EEA21780.1 - 0.031 14.5 3.3 0.19 12.0 0.9 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EEA21780.1 - 0.061 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EEA21780.1 - 0.15 12.4 3.3 0.36 11.2 0.6 2.6 1 1 1 2 2 2 0 AAA ATPase domain VanZ PF04892.12 EEA21780.1 - 1.8 9.2 9.3 7.4 7.2 0.5 3.6 3 1 0 3 3 3 0 VanZ like family Abhydrolase_3 PF07859.13 EEA21781.1 - 3.1e-52 177.5 0.0 4.6e-52 177.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA21781.1 - 6.7e-08 31.9 0.1 1.5e-07 30.7 0.1 1.6 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EEA21781.1 - 0.0003 20.3 0.0 0.34 10.4 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 EEA21781.1 - 0.019 14.5 0.2 0.031 13.8 0.2 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family DAO PF01266.24 EEA21782.1 - 3.1e-25 89.5 1.2 1.4e-24 87.3 1.2 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA21782.1 - 0.00012 22.5 0.8 0.00034 21.1 0.8 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA21782.1 - 0.0014 17.9 0.4 0.0062 15.8 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA21782.1 - 0.079 12.2 0.1 0.21 10.8 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AA_permease PF00324.21 EEA21783.1 - 5.3e-115 384.8 43.0 6e-115 384.6 43.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA21783.1 - 4.7e-23 81.7 49.8 9e-23 80.8 49.6 1.5 1 1 0 1 1 1 1 Amino acid permease Fungal_trans PF04082.18 EEA21784.1 - 1.5e-22 79.9 4.0 2.5e-22 79.2 4.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21784.1 - 0.0023 18.0 10.3 0.0041 17.2 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF498 PF04430.14 EEA21785.1 - 1.1e-28 99.4 0.0 1.7e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Alk_phosphatase PF00245.20 EEA21786.1 - 1.3e-106 357.0 0.0 1.6e-106 356.7 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EEA21786.1 - 4.7e-06 26.2 0.1 1e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily DUF3425 PF11905.8 EEA21787.1 - 1.1e-19 70.6 0.2 2.4e-19 69.5 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) ORC6 PF05460.13 EEA21787.1 - 0.32 10.2 3.3 0.41 9.9 3.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Aldo_ket_red PF00248.21 EEA21788.1 - 0.001 18.3 0.0 0.0013 18.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_16 PF00722.21 EEA21790.1 - 3.5e-43 147.1 1.6 6.2e-43 146.3 1.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 EEA21790.1 - 0.0025 18.2 13.8 0.0025 18.2 13.8 1.7 2 0 0 2 2 2 1 Chitin recognition protein Pro_dh PF01619.18 EEA21792.1 - 2.5e-61 207.8 0.1 3.2e-61 207.5 0.1 1.1 1 0 0 1 1 1 1 Proline dehydrogenase PMSR PF01625.21 EEA21793.1 - 3.4e-63 212.4 0.7 4.1e-63 212.1 0.7 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase KaiA PF07688.12 EEA21793.1 - 0.034 14.3 0.0 0.052 13.7 0.0 1.2 1 0 0 1 1 1 0 KaiA C-terminal domain PMSR PF01625.21 EEA21794.1 - 3.4e-63 212.4 0.7 4.1e-63 212.1 0.7 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase KaiA PF07688.12 EEA21794.1 - 0.034 14.3 0.0 0.052 13.7 0.0 1.2 1 0 0 1 1 1 0 KaiA C-terminal domain PMSR PF01625.21 EEA21795.1 - 3.4e-63 212.4 0.7 4.1e-63 212.1 0.7 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase KaiA PF07688.12 EEA21795.1 - 0.034 14.3 0.0 0.052 13.7 0.0 1.2 1 0 0 1 1 1 0 KaiA C-terminal domain Kinesin PF00225.23 EEA21796.1 - 5.1e-118 393.8 0.0 1.1e-117 392.7 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EEA21796.1 - 5.3e-27 94.6 2.0 6.3e-27 94.4 0.0 2.2 3 0 0 3 3 3 1 Microtubule binding Herpes_UL14 PF03580.14 EEA21796.1 - 0.0024 18.1 4.3 0.0061 16.8 4.3 1.6 1 0 0 1 1 1 1 Herpesvirus UL14-like protein AAA_33 PF13671.6 EEA21796.1 - 0.012 15.8 0.0 0.059 13.5 0.0 2.3 1 0 0 1 1 1 0 AAA domain DUF760 PF05542.11 EEA21796.1 - 0.094 13.1 0.0 18 5.8 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF760) Tim17 PF02466.19 EEA21798.1 - 0.00024 21.5 1.2 0.00039 20.8 1.2 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family cNMP_binding PF00027.29 EEA21799.1 - 1.2e-36 124.6 0.0 1.2e-21 76.6 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain cNMPbd_u2 PF16643.5 EEA21799.1 - 2.2e-35 122.5 4.5 2.2e-35 122.5 4.5 2.1 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein LRR_4 PF12799.7 EEA21799.1 - 9.8e-11 41.7 0.1 0.16 12.4 0.2 6.5 6 1 0 6 6 6 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EEA21799.1 - 9e-08 31.9 0.8 9e-08 31.9 0.8 2.0 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 EEA21799.1 - 2.6e-07 30.1 7.7 2.3 8.5 0.0 8.4 9 1 0 9 9 9 1 Leucine Rich repeat F-box PF00646.33 EEA21799.1 - 4.6e-06 26.4 4.1 1.3e-05 24.9 1.2 3.0 2 0 0 2 2 2 1 F-box domain SAM_Ste50p PF09235.10 EEA21799.1 - 0.17 12.2 1.6 19 5.6 0.3 3.8 3 1 0 3 3 3 0 Ste50p, sterile alpha motif Colipase-like PF15083.6 EEA21799.1 - 1.3 9.2 6.7 1.2 9.3 3.6 2.5 2 0 0 2 2 2 0 Colipase-like LRR_1 PF00560.33 EEA21799.1 - 2.8 8.9 16.8 18 6.3 0.0 7.4 9 0 0 9 9 9 0 Leucine Rich Repeat Zn_clus PF00172.18 EEA21800.1 - 6.1e-06 26.3 7.0 1.1e-05 25.5 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Slx4 PF09494.10 EEA21801.1 - 2.9e-23 81.6 0.0 1.3e-22 79.5 0.1 2.1 2 0 0 2 2 2 1 Slx4 endonuclease SAP PF02037.27 EEA21801.1 - 0.078 12.8 0.2 0.18 11.6 0.2 1.7 1 0 0 1 1 1 0 SAP domain CGI-121 PF08617.10 EEA21802.1 - 2.8e-54 183.6 0.1 3.3e-54 183.4 0.1 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 CAMP_factor PF07373.11 EEA21802.1 - 0.057 13.0 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 CAMP factor (Cfa) Bax1-I PF01027.20 EEA21803.1 - 5.8e-33 114.5 8.8 8.9e-33 113.9 8.8 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF963 PF06131.11 EEA21803.1 - 0.0078 15.6 1.3 0.015 14.7 1.3 1.4 1 0 0 1 1 1 1 Schizosaccharomyces pombe repeat of unknown function (DUF963) RRM_1 PF00076.22 EEA21804.1 - 2.3e-15 56.2 0.0 3.3e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA21804.1 - 0.006 16.2 0.0 0.0088 15.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EEA21804.1 - 0.071 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Glyco_hydro_76 PF03663.14 EEA21805.1 - 2.5e-23 83.2 0.0 1e-22 81.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 IATP PF04568.12 EEA21806.1 - 2.9e-26 91.7 0.9 3.4e-26 91.6 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP BLOC1_2 PF10046.9 EEA21806.1 - 0.0043 17.3 2.7 0.0056 16.9 2.7 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 TssO PF17561.2 EEA21806.1 - 0.0046 17.1 2.2 0.0059 16.7 2.2 1.1 1 0 0 1 1 1 1 Type VI secretion system, TssO DUF4140 PF13600.6 EEA21806.1 - 0.015 15.8 0.5 0.018 15.5 0.5 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) AdoHcyase PF05221.17 EEA21806.1 - 0.015 14.4 0.3 0.019 14.1 0.3 1.1 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase FapA PF03961.13 EEA21806.1 - 0.017 13.8 0.2 0.017 13.8 0.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A NPV_P10 PF05531.12 EEA21806.1 - 0.052 14.0 0.5 0.069 13.6 0.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein PKHD_C PF18331.1 EEA21806.1 - 0.069 13.2 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain DivIC PF04977.15 EEA21806.1 - 0.16 11.8 3.5 0.24 11.2 3.5 1.3 1 0 0 1 1 1 0 Septum formation initiator 14-3-3 PF00244.20 EEA21807.1 - 1.2e-105 351.9 5.6 1.5e-105 351.7 5.6 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF2205 PF10224.9 EEA21808.1 - 3.4e-34 116.6 2.0 5.1e-34 116.1 2.0 1.3 1 0 0 1 1 1 1 Short coiled-coil protein DUF3450 PF11932.8 EEA21808.1 - 0.0019 17.5 4.1 0.0025 17.2 4.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) YabA PF06156.13 EEA21808.1 - 0.011 16.4 2.7 0.015 15.9 2.7 1.2 1 0 0 1 1 1 0 Initiation control protein YabA CASP_C PF08172.12 EEA21808.1 - 0.012 15.0 3.6 0.019 14.3 3.6 1.3 1 0 0 1 1 1 0 CASP C terminal RBD-FIP PF09457.10 EEA21808.1 - 0.024 14.5 0.1 0.049 13.6 0.1 1.5 1 0 0 1 1 1 0 FIP domain DivIC PF04977.15 EEA21808.1 - 0.11 12.3 3.7 0.17 11.7 3.7 1.3 1 0 0 1 1 1 0 Septum formation initiator JIP_LZII PF16471.5 EEA21808.1 - 0.11 12.6 3.3 0.25 11.6 3.3 1.6 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II bZIP_1 PF00170.21 EEA21808.1 - 0.13 12.4 4.8 0.32 11.1 4.6 1.7 1 1 1 2 2 2 0 bZIP transcription factor DUF5320 PF17253.2 EEA21808.1 - 0.84 10.7 3.6 1.9 9.6 2.1 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5320) NAD_binding_3 PF03447.16 EEA21809.1 - 0.065 13.9 0.1 0.12 13.1 0.1 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain DUF4226 PF10774.9 EEA21809.1 - 0.082 13.2 0.6 0.15 12.4 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4226) Nsp1_C PF05064.13 EEA21810.1 - 2.6e-39 133.6 0.8 6e-39 132.4 0.8 1.5 1 0 0 1 1 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EEA21810.1 - 1.3e-05 26.0 142.3 0.014 16.2 22.5 6.9 2 1 7 9 9 8 3 Nucleoporin FG repeat region GAT PF03127.14 EEA21810.1 - 0.086 13.2 0.7 0.46 10.8 0.0 2.3 1 1 1 2 2 2 0 GAT domain DUF4407 PF14362.6 EEA21810.1 - 0.15 11.4 3.0 0.26 10.6 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 EEA21810.1 - 0.16 12.3 9.0 0.053 13.9 1.6 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) ERM PF00769.19 EEA21810.1 - 0.17 11.7 6.4 0.27 11.0 6.4 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF4200 PF13863.6 EEA21810.1 - 0.31 11.4 8.4 1.6 9.1 4.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF16 PF01519.16 EEA21810.1 - 0.82 10.2 3.2 5.3 7.6 3.0 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 Snapin_Pallidin PF14712.6 EEA21810.1 - 1.3 9.5 2.9 1.8 9.1 0.2 2.3 3 0 0 3 3 2 0 Snapin/Pallidin CK2S PF15011.6 EEA21810.1 - 1.3 8.8 3.5 25 4.7 1.5 2.3 2 0 0 2 2 2 0 Casein Kinase 2 substrate Uso1_p115_C PF04871.13 EEA21810.1 - 1.5 9.2 6.2 1.6 9.1 2.7 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region GAS PF13851.6 EEA21810.1 - 1.9 7.8 5.9 3.2 7.0 5.9 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TACC_C PF05010.14 EEA21810.1 - 2.4 7.9 8.4 12 5.6 8.3 1.9 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Laminin_II PF06009.12 EEA21810.1 - 2.4 8.2 5.8 18 5.3 1.3 2.4 2 1 0 2 2 2 0 Laminin Domain II AAA_13 PF13166.6 EEA21810.1 - 5.8 5.4 7.9 7.4 5.1 2.3 2.0 1 1 1 2 2 2 0 AAA domain HIP1_clath_bdg PF16515.5 EEA21810.1 - 7.5 7.2 9.7 1.1e+02 3.5 6.5 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF5102 PF17104.5 EEA21811.1 - 5.1e-110 368.1 1.2 5.1e-110 368.1 1.2 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5102) PhyH PF05721.13 EEA21812.1 - 3.4e-15 56.9 0.0 4.4e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) zf-MIZ PF02891.20 EEA21813.1 - 3.1e-09 36.5 0.2 8.1e-09 35.1 0.2 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EEA21813.1 - 2e-05 24.3 0.4 4.4e-05 23.2 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PH PF00169.29 EEA21814.1 - 1.8e-11 44.4 0.0 5.7e-11 42.9 0.0 1.8 1 1 0 1 1 1 1 PH domain SH3_9 PF14604.6 EEA21814.1 - 1.1e-10 41.2 0.1 2.3e-10 40.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EEA21814.1 - 1.4e-09 37.4 0.0 3.2e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 EEA21814.1 - 3e-09 36.9 0.2 5.1e-09 36.1 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 EEA21814.1 - 0.00024 20.7 0.1 0.00052 19.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EEA21814.1 - 0.012 16.1 0.0 0.028 14.8 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain SAM_1 PF00536.30 EEA21814.1 - 0.038 14.4 0.1 0.076 13.5 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PH_8 PF15409.6 EEA21814.1 - 0.046 14.0 0.0 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain Metallophos PF00149.28 EEA21815.1 - 0.00039 21.0 3.2 0.0011 19.5 3.2 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Diphthamide_syn PF01866.17 EEA21817.1 - 1.2e-87 294.2 0.0 3e-87 292.9 0.0 1.6 1 1 0 1 1 1 1 Putative diphthamide synthesis protein Fe-ADH PF00465.19 EEA21818.1 - 1e-79 268.0 0.2 1.2e-79 267.8 0.2 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EEA21818.1 - 1.5e-15 57.6 0.1 2e-15 57.2 0.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase IMS_C PF11799.8 EEA21818.1 - 0.081 13.6 0.0 0.3 11.8 0.0 2.1 1 1 0 1 1 1 0 impB/mucB/samB family C-terminal domain ANAPC4_WD40 PF12894.7 EEA21819.1 - 7.9e-10 38.9 0.0 0.0013 19.0 0.0 3.1 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA21819.1 - 2.1e-06 28.3 4.4 0.072 14.0 0.5 5.0 6 0 0 6 6 6 2 WD domain, G-beta repeat Sporozoite_P67 PF05642.11 EEA21821.1 - 6.6e-05 21.2 1.1 0.00016 19.9 1.1 1.7 1 1 0 1 1 1 1 Sporozoite P67 surface antigen CRF PF00473.17 EEA21822.1 - 0.17 11.9 0.1 0.31 11.2 0.1 1.3 1 0 0 1 1 1 0 Corticotropin-releasing factor family Mnd1 PF03962.15 EEA21824.1 - 7.7e-22 77.4 0.9 2e-21 76.1 0.0 2.1 2 0 0 2 2 2 1 Mnd1 HTH domain Dynamitin PF04912.14 EEA21824.1 - 0.0019 17.6 4.6 0.0026 17.2 4.6 1.2 1 0 0 1 1 1 1 Dynamitin DUF3584 PF12128.8 EEA21824.1 - 0.0021 15.7 8.2 0.003 15.2 8.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DsrD PF08679.11 EEA21824.1 - 0.024 14.9 0.0 0.24 11.7 0.0 2.3 1 1 1 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) DUF4407 PF14362.6 EEA21824.1 - 0.066 12.6 1.6 0.096 12.0 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) End3 PF12761.7 EEA21824.1 - 0.14 12.3 11.3 0.29 11.3 11.3 1.5 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 HMMR_N PF15905.5 EEA21824.1 - 0.2 11.1 13.8 0.29 10.6 13.8 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal BLOC1_2 PF10046.9 EEA21824.1 - 0.23 11.8 7.8 0.74 10.1 0.2 2.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Dad4 PF08650.10 EEA21824.1 - 1.2 9.2 4.3 5 7.2 0.5 2.7 3 0 0 3 3 3 0 DASH complex subunit Dad4 DUF2203 PF09969.9 EEA21824.1 - 2.5 8.9 7.2 25 5.6 6.7 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) OmpH PF03938.14 EEA21824.1 - 8 6.8 13.1 15 6.0 13.1 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) UAF_Rrn10 PF05234.11 EEA21825.1 - 0.16 12.2 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 UAF complex subunit Rrn10 WD40 PF00400.32 EEA21826.1 - 5.3e-19 68.2 13.7 0.00027 21.7 0.4 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA21826.1 - 1.7e-07 31.4 0.5 0.29 11.5 0.0 4.9 3 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Arrestin_N PF00339.29 EEA21828.1 - 1.4e-17 64.1 0.0 2e-16 60.4 0.0 2.6 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EEA21828.1 - 1.4e-08 35.2 0.0 1.5e-05 25.4 0.0 3.2 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain SHR3_chaperone PF08229.11 EEA21829.1 - 4e-78 260.7 0.0 4.7e-78 260.5 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF5453 PF17534.2 EEA21829.1 - 0.017 15.1 0.3 0.027 14.4 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5453) MFS_1 PF07690.16 EEA21829.1 - 0.035 13.0 3.4 0.059 12.3 3.5 1.4 1 1 0 1 1 1 0 Major Facilitator Superfamily Fungal_trans_2 PF11951.8 EEA21830.1 - 8.5e-99 331.0 0.0 1.1e-98 330.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21830.1 - 0.00018 21.6 13.4 0.00031 20.8 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAM_2 PF07647.17 EEA21831.1 - 6.6e-11 42.2 0.0 1.9e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 EEA21831.1 - 3.6e-08 33.9 0.1 1.3e-07 32.1 0.1 2.1 1 0 0 1 1 1 1 PH domain SAM_1 PF00536.30 EEA21831.1 - 3.6e-08 33.7 0.2 2.1e-07 31.2 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 EEA21831.1 - 6.5e-05 22.7 0.0 0.00029 20.6 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SR-25 PF10500.9 EEA21831.1 - 4 7.0 15.0 0.37 10.4 10.1 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ank_2 PF12796.7 EEA21832.1 - 6.4e-60 199.7 13.5 7.6e-12 45.7 0.4 7.6 2 1 6 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA21832.1 - 9.1e-59 195.1 14.1 5.5e-12 46.0 0.1 11.6 4 2 9 13 13 13 12 Ankyrin repeats (many copies) Ank PF00023.30 EEA21832.1 - 3e-48 160.2 20.5 5.6e-08 32.9 0.1 13.2 13 0 0 13 13 13 9 Ankyrin repeat Ank_3 PF13606.6 EEA21832.1 - 1.3e-44 145.0 17.4 1.2e-05 25.3 0.1 13.5 14 0 0 14 14 14 8 Ankyrin repeat Ank_5 PF13857.6 EEA21832.1 - 9.4e-40 134.2 19.0 5.6e-08 32.9 0.0 10.0 5 1 7 12 12 12 10 Ankyrin repeats (many copies) NACHT PF05729.12 EEA21832.1 - 9.1e-08 32.2 0.1 7.4e-07 29.2 0.0 2.6 3 0 0 3 3 3 1 NACHT domain AAA_16 PF13191.6 EEA21832.1 - 4.8e-07 30.3 0.1 2.9e-06 27.8 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EEA21832.1 - 3.6e-06 27.3 0.0 2.1e-05 24.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EEA21832.1 - 0.018 15.4 0.0 0.083 13.3 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) APG5 PF04106.12 EEA21833.1 - 4.1e-61 206.5 0.0 5e-61 206.2 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 DUF4192 PF13830.6 EEA21834.1 - 1.5 8.9 3.4 0.79 9.7 0.6 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4192) Hydrolase_4 PF12146.8 EEA21836.1 - 3.7e-10 39.5 0.1 8.8e-10 38.2 0.1 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA21836.1 - 1.1e-08 35.9 0.2 1.6e-08 35.4 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA21836.1 - 2.2e-08 34.1 3.4 3.2e-07 30.3 3.4 2.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 EEA21836.1 - 0.074 12.7 0.4 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DLH PF01738.18 EEA21836.1 - 0.092 12.3 0.1 3 7.4 0.0 2.6 2 1 1 3 3 3 0 Dienelactone hydrolase family ABC_membrane PF00664.23 EEA21837.1 - 3.5e-55 187.6 42.1 5.4e-36 124.7 20.3 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EEA21837.1 - 2.8e-50 170.4 0.2 1.2e-28 100.3 0.3 2.8 2 0 0 2 2 2 2 ABC transporter Zeta_toxin PF06414.12 EEA21837.1 - 2.7e-06 26.8 0.1 0.0015 17.9 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.23 EEA21837.1 - 1.2e-05 25.3 0.7 0.022 14.8 0.2 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase SMC_N PF02463.19 EEA21837.1 - 6.9e-05 22.4 4.6 0.68 9.3 1.7 3.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA21837.1 - 7.7e-05 23.1 1.3 0.62 10.4 1.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EEA21837.1 - 0.00029 20.5 1.9 0.55 10.0 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EEA21837.1 - 0.0005 20.0 4.7 0.71 9.6 0.3 3.6 2 2 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA21837.1 - 0.0022 17.9 2.2 0.74 9.7 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EEA21837.1 - 0.0044 17.1 4.3 0.24 11.4 0.3 3.1 2 1 0 2 2 2 1 Dynamin family DUF87 PF01935.17 EEA21837.1 - 0.011 15.9 2.2 0.31 11.1 0.3 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_18 PF13238.6 EEA21837.1 - 0.015 15.8 0.1 3.3 8.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 EEA21837.1 - 0.032 14.5 4.8 2 8.7 0.1 3.5 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EEA21837.1 - 0.071 12.0 1.4 1.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_15 PF13175.6 EEA21837.1 - 0.079 12.7 5.1 2.4 7.8 0.3 2.5 3 0 0 3 3 2 0 AAA ATPase domain Roc PF08477.13 EEA21837.1 - 0.088 13.0 0.3 18 5.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 EEA21837.1 - 0.1 13.1 11.1 1.2 9.6 2.7 3.5 3 1 0 3 3 3 0 AAA domain Ploopntkinase3 PF18751.1 EEA21837.1 - 0.15 12.0 1.3 13 5.7 0.1 2.6 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 AAA PF00004.29 EEA21837.1 - 0.16 12.4 0.4 8.6 6.8 0.0 3.0 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EEA21837.1 - 0.23 11.1 4.8 4.6 6.9 0.2 2.9 3 0 0 3 3 3 0 AAA domain CDC45 PF02724.14 EEA21837.1 - 0.73 8.1 10.1 0.0062 14.9 1.3 1.9 2 0 0 2 2 2 0 CDC45-like protein ATP_bind_1 PF03029.17 EEA21837.1 - 1.9 8.2 6.0 13 5.5 0.1 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein SnoaL PF07366.12 EEA21838.1 - 1.2e-18 67.1 0.0 4.9e-18 65.1 0.0 1.8 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EEA21838.1 - 5.9e-13 49.3 0.1 8.5e-13 48.8 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain Aminotran_3 PF00202.21 EEA21839.1 - 2.3e-113 378.9 0.0 2.6e-113 378.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EEA21839.1 - 0.051 12.9 0.0 0.099 11.9 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EEA21839.1 - 0.084 12.0 0.0 0.62 9.2 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class I and II Aminotran_3 PF00202.21 EEA21840.1 - 6.1e-103 344.6 0.0 7e-103 344.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EEA21840.1 - 0.038 13.3 0.0 0.074 12.3 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EEA21840.1 - 0.076 12.2 0.0 0.73 8.9 0.0 2.0 2 0 0 2 2 2 0 Aminotransferase class I and II Glyco_transf_22 PF03901.17 EEA21841.1 - 2.4e-79 267.5 12.6 3.1e-79 267.1 12.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family AtpR PF12966.7 EEA21841.1 - 0.24 11.9 2.6 1.4 9.4 0.5 3.0 2 1 1 3 3 3 0 N-ATPase, AtpR subunit ArfGap PF01412.18 EEA21842.1 - 1.8e-36 124.7 0.1 5.1e-36 123.3 0.1 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Zn_clus PF00172.18 EEA21843.1 - 0.00046 20.2 2.4 0.00088 19.3 2.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ERAP1_C PF11838.8 EEA21844.1 - 1.8e-90 303.7 3.9 1.1e-89 301.1 0.9 2.3 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EEA21844.1 - 1.1e-85 286.7 0.7 1.9e-85 285.9 0.7 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EEA21844.1 - 7.8e-54 182.7 1.3 7.8e-54 182.7 1.3 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF2808 PF10989.8 EEA21844.1 - 0.011 15.8 0.1 0.025 14.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) DUF3543 PF12063.8 EEA21845.1 - 1.5e-98 329.2 0.0 2.1e-98 328.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EEA21845.1 - 6.3e-62 209.3 0.0 1.1e-61 208.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA21845.1 - 2.1e-41 141.9 0.0 3.6e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Diphthami_syn_2 PF01902.17 EEA21847.1 - 3.7e-18 65.8 0.0 7.7e-12 45.2 0.0 3.6 3 1 0 3 3 3 3 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EEA21847.1 - 3e-17 62.8 0.0 4.9e-09 36.3 0.0 4.1 4 0 0 4 4 4 2 Endoribonuclease L-PSP Radial_spoke PF04712.12 EEA21847.1 - 0.0015 17.6 1.3 0.0024 16.9 1.3 1.2 1 0 0 1 1 1 1 Radial spokehead-like protein Cwf_Cwc_15 PF04889.12 EEA21847.1 - 0.0015 18.3 0.1 0.0042 16.9 0.1 1.6 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein HBS1_N PF08938.10 EEA21847.1 - 3.4 8.0 6.7 23 5.4 2.3 2.9 3 0 0 3 3 3 0 HBS1 N-terminus FAM176 PF14851.6 EEA21847.1 - 4.6 6.9 5.9 2.6 7.7 1.1 2.5 3 0 0 3 3 3 0 FAM176 family zf-C2H2 PF00096.26 EEA21848.1 - 3.9e-12 45.9 14.2 1.6e-06 28.3 1.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA21848.1 - 2.2e-07 31.1 12.1 0.0024 18.6 0.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA21848.1 - 2.7e-06 27.5 6.1 2.7e-06 27.5 6.1 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EEA21848.1 - 1.6e-05 25.1 4.1 0.011 16.0 0.5 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EEA21848.1 - 0.00027 21.2 5.5 0.0074 16.7 0.3 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EEA21848.1 - 0.00089 19.2 11.5 0.018 15.1 2.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EEA21848.1 - 0.2 11.3 8.1 1.4 8.6 0.4 2.7 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-LYAR PF08790.11 EEA21848.1 - 0.28 11.1 2.7 16 5.5 0.3 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2HE PF16278.5 EEA21848.1 - 0.74 10.3 7.4 79 3.8 7.4 2.6 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 EEA21848.1 - 1.3 9.7 4.4 6.5 7.5 0.4 2.7 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EEA21848.1 - 1.7 8.4 9.3 8.6 6.2 0.1 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EEA21848.1 - 1.9 8.9 5.1 13 6.2 0.5 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 EEA21848.1 - 2.2 8.4 6.4 0.76 9.9 2.4 2.1 1 1 1 2 2 2 0 BED zinc finger Peptidase_M3 PF01432.20 EEA21849.1 - 3.7e-137 458.3 0.0 4.2e-137 458.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Stap_Strp_tox_C PF02876.17 EEA21850.1 - 0.025 14.9 0.0 0.034 14.5 0.0 1.4 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Syntaxin-6_N PF09177.11 EEA21850.1 - 0.074 13.6 0.7 0.36 11.4 0.4 2.2 2 1 0 2 2 2 0 Syntaxin 6, N-terminal PITH PF06201.13 EEA21851.1 - 4e-35 121.3 0.0 6.4e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 EEA21851.1 - 7.5e-29 99.8 0.0 1.4e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EEA21851.1 - 2.4e-06 27.1 0.0 5.6e-06 25.9 0.0 1.6 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EEA21851.1 - 3.1e-06 27.4 0.1 2.2e-05 24.7 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EEA21851.1 - 4.2e-06 27.2 0.4 2.1e-05 24.9 0.4 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 EEA21851.1 - 1.9e-05 24.4 0.2 0.098 12.4 0.0 2.4 1 1 1 2 2 2 2 Redoxin AhpC-TSA PF00578.21 EEA21851.1 - 0.00015 21.7 0.3 0.0046 16.9 0.2 2.3 1 1 1 2 2 2 2 AhpC/TSA family Thioredoxin_9 PF14595.6 EEA21851.1 - 0.00086 19.1 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin NIF PF03031.18 EEA21851.1 - 0.0028 17.5 0.0 0.005 16.6 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase TraF PF13728.6 EEA21851.1 - 0.012 15.5 0.1 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein HyaE PF07449.11 EEA21851.1 - 0.016 15.2 0.0 0.048 13.6 0.0 1.8 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 EEA21851.1 - 0.054 13.7 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like DIM1 PF02966.16 EEA21851.1 - 0.082 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 zf-CSL PF05207.13 EEA21852.1 - 5.4e-19 67.7 0.4 9.2e-19 66.9 0.4 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EEA21852.1 - 6.4e-13 48.6 0.4 1.5e-12 47.5 0.4 1.7 1 0 0 1 1 1 1 DnaJ domain VSP PF03302.13 EEA21852.1 - 0.16 10.8 0.2 0.26 10.1 0.2 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein peroxidase PF00141.23 EEA21853.1 - 1.9e-47 161.9 0.0 3e-47 161.3 0.0 1.2 1 0 0 1 1 1 1 Peroxidase DEAD PF00270.29 EEA21854.1 - 1.3e-47 161.8 0.0 8.3e-47 159.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA21854.1 - 1.4e-29 102.7 0.0 1.3e-28 99.6 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA21854.1 - 0.0013 18.8 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2986 PF11661.8 EEA21854.1 - 0.0029 18.1 2.4 0.013 16.0 2.4 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2986) DUF3334 PF11813.8 EEA21854.1 - 0.066 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3334) Ank_2 PF12796.7 EEA21855.1 - 1.1e-20 73.9 1.1 5.2e-10 39.8 0.1 2.8 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA21855.1 - 2.3e-12 47.2 0.9 4.1e-05 24.1 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA21855.1 - 4.1e-11 42.1 3.1 0.44 11.3 0.0 5.8 5 1 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EEA21855.1 - 4.2e-10 39.7 1.4 0.74 10.2 0.0 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA21855.1 - 0.00037 20.8 4.3 2.7 8.6 0.0 4.3 5 0 0 5 5 5 2 Ankyrin repeat TPR_14 PF13428.6 EEA21856.1 - 8.9e-07 29.2 13.6 0.012 16.4 0.3 8.1 7 2 3 10 10 10 2 Tetratricopeptide repeat Suf PF05843.14 EEA21856.1 - 1.1e-06 28.8 2.4 6.6e-05 23.0 0.1 3.1 2 1 1 3 3 3 1 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EEA21856.1 - 0.011 16.2 0.0 6.7 7.3 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EEA21856.1 - 0.024 15.0 0.4 10 6.8 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA21856.1 - 0.077 13.3 0.2 0.81 10.0 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Gla PF00594.20 EEA21856.1 - 1.4 9.2 0.0 1.4 9.2 0.0 4.5 6 0 0 6 6 6 0 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Mitoc_mL59 PF18126.1 EEA21857.1 - 1.2e-46 158.2 12.1 4.3e-46 156.4 12.1 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 HetR_C PF18460.1 EEA21857.1 - 0.2 11.6 1.4 0.34 10.9 0.2 1.9 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain MOSC PF03473.17 EEA21858.1 - 2.8e-32 111.5 0.0 5.1e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 MOSC domain Aminotran_5 PF00266.19 EEA21858.1 - 8.7e-25 87.4 0.0 5.8e-24 84.7 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V MOSC_N PF03476.16 EEA21858.1 - 1.6e-23 82.8 0.0 3.5e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MARVEL PF01284.23 EEA21859.1 - 0.028 14.4 20.3 0.04 14.0 20.3 1.2 1 0 0 1 1 1 0 Membrane-associating domain SelK_SelG PF10961.8 EEA21859.1 - 0.69 10.6 0.1 0.69 10.6 0.1 2.7 2 1 1 3 3 3 0 Selenoprotein SelK_SelG DUF2070 PF09843.9 EEA21859.1 - 7.1 4.8 13.8 9.4 4.4 13.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PAP2 PF01569.21 EEA21860.1 - 4.3e-28 97.8 0.5 4.3e-28 97.8 0.5 1.6 2 0 0 2 2 2 1 PAP2 superfamily SafA PF17073.5 EEA21860.1 - 0.013 15.4 0.1 4.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Two-component-system connector protein SLATT_1 PF18181.1 EEA21860.1 - 0.022 14.7 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Luteo_Vpg PF01659.16 EEA21860.1 - 0.14 12.5 3.5 0.29 11.5 3.5 1.5 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein NGP1NT PF08153.12 EEA21862.1 - 3e-50 169.7 0.1 4.7e-50 169.1 0.1 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EEA21862.1 - 9.3e-18 64.4 1.0 1e-13 51.3 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA21862.1 - 5.4e-06 26.0 0.0 8e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EEA21862.1 - 0.00019 21.4 0.0 0.00043 20.2 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EEA21862.1 - 0.00077 19.0 0.1 0.16 11.4 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.23 EEA21862.1 - 0.0013 18.8 0.1 1.2 9.2 0.0 3.5 2 1 1 3 3 3 1 Dynamin family SDA1 PF05285.12 EEA21862.1 - 0.0088 15.5 18.4 0.0088 15.5 18.4 1.5 2 0 0 2 2 2 1 SDA1 Roc PF08477.13 EEA21862.1 - 0.1 12.8 0.0 25 5.1 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.25 EEA21863.1 - 6e-38 130.7 0.0 1.2e-37 129.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA21863.1 - 2e-27 96.1 0.0 3.3e-27 95.4 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA21863.1 - 0.00036 20.0 0.0 0.00058 19.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA21863.1 - 0.013 14.9 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EEA21863.1 - 0.028 13.4 0.0 0.043 12.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EEA21863.1 - 0.048 13.6 0.3 0.78 9.6 0.3 2.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EEA21863.1 - 0.053 12.3 0.3 0.1 11.3 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Prefoldin_3 PF13758.6 EEA21864.1 - 1.7e-35 121.0 2.9 1.4e-34 118.1 3.2 2.3 2 0 0 2 2 2 1 Prefoldin subunit DUF3835 PF12927.7 EEA21864.1 - 3.8e-22 78.9 1.5 3.8e-22 78.9 1.5 4.7 4 2 1 5 5 5 2 Domain of unknown function (DUF3835) Val_tRNA-synt_C PF10458.9 EEA21864.1 - 2 8.8 6.7 3.8 7.9 0.1 3.5 4 0 0 4 4 4 0 Valyl tRNA synthetase tRNA binding arm MAT1 PF06391.13 EEA21865.1 - 1.8e-42 145.5 9.6 2.4e-42 145.1 9.6 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EEA21865.1 - 3e-32 110.2 8.9 4.4e-32 109.7 8.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA21865.1 - 6.4e-05 22.7 4.1 0.00015 21.5 4.1 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA21865.1 - 0.0002 21.2 5.7 0.00034 20.4 5.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA21865.1 - 0.00023 20.9 4.0 0.00047 20.0 4.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA21865.1 - 0.00078 19.7 6.6 0.0013 19.0 6.6 1.4 1 0 0 1 1 1 1 Ring finger domain Zn_ribbon_17 PF17120.5 EEA21865.1 - 0.0058 16.2 1.5 0.011 15.4 1.5 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EEA21865.1 - 0.01 15.6 6.4 0.043 13.6 1.7 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 EEA21865.1 - 0.029 14.3 8.5 0.42 10.6 9.0 2.2 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA21865.1 - 0.099 12.7 6.9 0.19 11.8 6.9 1.5 1 0 0 1 1 1 0 RING-type zinc-finger DUF3797 PF12677.7 EEA21865.1 - 0.28 11.1 2.5 0.73 9.8 2.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) Prok-RING_4 PF14447.6 EEA21865.1 - 0.58 10.1 9.6 23 4.9 10.4 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Cep57_MT_bd PF06657.13 EEA21866.1 - 1.5e-28 99.0 1.3 1.5e-28 99.0 1.3 3.4 3 0 0 3 3 3 1 Centrosome microtubule-binding domain of Cep57 Cep57_CLD_2 PF14197.6 EEA21866.1 - 6.1e-22 77.5 8.0 6.1e-22 77.5 8.0 4.3 4 0 0 4 4 4 1 Centrosome localisation domain of PPC89 GrpE PF01025.19 EEA21866.1 - 0.0034 17.1 1.7 0.0034 17.1 1.7 4.0 3 1 0 4 4 4 1 GrpE DUF3090 PF11290.8 EEA21866.1 - 4.2 7.2 9.5 0.16 11.8 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3090) SKG6 PF08693.10 EEA21867.1 - 0.0016 17.8 3.6 0.0027 17.1 3.6 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain ABC_membrane PF00664.23 EEA21868.1 - 4.5e-67 226.6 37.6 1e-33 117.1 17.9 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA21868.1 - 7.3e-58 194.9 0.0 4.8e-29 101.6 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 EEA21868.1 - 9.8e-17 61.1 4.3 4.4e-07 29.6 0.1 4.9 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA21868.1 - 2.7e-09 37.3 0.3 0.55 10.0 0.0 4.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA21868.1 - 7.5e-09 35.2 0.5 0.0025 17.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EEA21868.1 - 1.5e-08 34.7 0.2 0.00043 20.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EEA21868.1 - 5.1e-07 30.2 0.7 0.0081 16.6 0.0 3.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA21868.1 - 1.4e-06 28.6 0.8 0.2 11.9 0.1 4.5 4 1 0 4 4 4 2 AAA domain MMR_HSR1 PF01926.23 EEA21868.1 - 1.7e-06 28.1 0.1 0.0052 16.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EEA21868.1 - 9.8e-06 26.2 0.6 0.11 13.0 0.2 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EEA21868.1 - 1.7e-05 24.6 0.1 0.057 13.1 0.0 3.6 2 2 0 2 2 2 1 AAA domain DUF87 PF01935.17 EEA21868.1 - 7.4e-05 23.0 0.3 0.29 11.2 0.1 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain Zeta_toxin PF06414.12 EEA21868.1 - 9.1e-05 21.8 0.0 0.015 14.6 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.6 EEA21868.1 - 0.00048 19.8 0.2 2.1 7.8 0.0 3.5 4 0 0 4 4 4 2 AAA domain AAA_15 PF13175.6 EEA21868.1 - 0.00083 19.2 1.2 0.37 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 EEA21868.1 - 0.0023 18.0 0.1 0.95 9.5 0.0 2.4 2 0 0 2 2 2 1 Dynamin family FtsK_SpoIIIE PF01580.18 EEA21868.1 - 0.0025 17.2 0.0 1.6 8.0 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family SbcCD_C PF13558.6 EEA21868.1 - 0.0039 17.4 0.8 1 9.6 0.0 3.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ABC_ATPase PF09818.9 EEA21868.1 - 0.0047 15.8 6.1 2.1 7.0 0.1 3.9 4 1 0 4 4 4 2 Predicted ATPase of the ABC class DEAD PF00270.29 EEA21868.1 - 0.0075 16.0 0.0 5.4 6.8 0.0 3.0 3 1 0 3 3 3 0 DEAD/DEAH box helicase IstB_IS21 PF01695.17 EEA21868.1 - 0.011 15.5 1.2 1.1 8.9 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein Septin PF00735.18 EEA21868.1 - 0.011 15.0 0.4 0.3 10.3 0.0 2.5 3 0 0 3 3 2 0 Septin cobW PF02492.19 EEA21868.1 - 0.018 14.7 0.3 1.7 8.2 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EEA21868.1 - 0.038 14.1 0.9 8.8 6.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EEA21868.1 - 0.044 13.7 0.0 9.4 6.1 0.0 3.0 3 0 0 3 3 2 0 NACHT domain AAA_7 PF12775.7 EEA21868.1 - 0.06 12.9 0.1 7.7 6.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EEA21868.1 - 0.062 12.6 2.1 6.6 6.0 0.0 3.2 3 0 0 3 3 3 0 KaiC Ploopntkinase3 PF18751.1 EEA21868.1 - 0.1 12.5 0.2 4.6 7.1 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 RNA_helicase PF00910.22 EEA21868.1 - 0.12 12.8 0.2 7.9 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 EEA21868.1 - 0.13 12.9 0.3 25 5.4 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EEA21868.1 - 0.13 12.2 0.4 29 4.6 0.1 3.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EEA21868.1 - 0.14 11.8 0.2 23 4.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 EEA21868.1 - 0.15 10.9 1.9 6.8 5.5 0.1 2.7 3 0 0 3 3 3 0 AAA-like domain Guanylate_kin PF00625.21 EEA21868.1 - 0.16 11.6 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase DUF3987 PF13148.6 EEA21868.1 - 0.19 10.7 0.1 6.8 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) NTPase_1 PF03266.15 EEA21868.1 - 0.43 10.5 3.6 7.7 6.4 0.1 3.6 3 0 0 3 3 3 0 NTPase Polysacc_synt_4 PF04669.13 EEA21869.1 - 4.9e-23 81.7 1.0 1.4e-21 76.9 1.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Polysacc_synt_4 PF04669.13 EEA21870.1 - 2.6e-20 72.8 0.8 9.2e-19 67.7 0.8 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Polysacc_synt_4 PF04669.13 EEA21871.1 - 2.6e-20 72.8 0.8 9.2e-19 67.7 0.8 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Ric8 PF10165.9 EEA21872.1 - 2.2e-110 369.8 0.1 5.8e-110 368.5 0.0 1.6 2 0 0 2 2 2 1 Guanine nucleotide exchange factor synembryn Ric8 PF10165.9 EEA21873.1 - 2.7e-104 349.8 0.1 7.9e-104 348.2 0.0 1.6 2 0 0 2 2 2 1 Guanine nucleotide exchange factor synembryn MFS_1 PF07690.16 EEA21874.1 - 1.4e-24 86.7 47.1 3.2e-24 85.5 47.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily CorA PF01544.18 EEA21875.1 - 3.2e-07 30.0 2.9 7.3e-07 28.8 2.9 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein TadE PF07811.12 EEA21875.1 - 0.059 13.6 0.9 0.14 12.4 0.9 1.6 1 0 0 1 1 1 0 TadE-like protein MFS_1 PF07690.16 EEA21876.1 - 1.1e-27 96.9 69.1 2e-23 82.9 45.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Rif1_N PF12231.8 EEA21877.1 - 5.3e-137 456.8 1.5 5.3e-137 456.8 1.5 2.1 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal bZIP_1 PF00170.21 EEA21879.1 - 7.4e-06 26.0 14.9 1.4e-05 25.1 14.9 1.5 1 1 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EEA21879.1 - 0.0007 20.1 7.6 0.001 19.6 7.6 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Glutaredoxin2_C PF04399.13 EEA21879.1 - 0.018 14.9 0.4 0.026 14.4 0.4 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Vac_Fusion PF02346.16 EEA21879.1 - 0.027 14.1 0.4 0.052 13.2 0.4 1.5 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 AAA_11 PF13086.6 EEA21879.1 - 0.052 13.3 0.6 0.058 13.2 0.6 1.1 1 0 0 1 1 1 0 AAA domain 7tm_7 PF08395.12 EEA21879.1 - 0.059 12.6 5.7 1.6 7.8 0.3 2.1 2 0 0 2 2 2 0 7tm Chemosensory receptor DUF2400 PF09674.10 EEA21879.1 - 0.063 13.3 2.4 0.086 12.8 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) Spt5_N PF11942.8 EEA21879.1 - 0.068 14.2 3.9 0.1 13.6 3.9 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal SlyX PF04102.12 EEA21879.1 - 0.07 13.8 1.2 0.07 13.8 1.2 1.6 1 1 1 2 2 2 0 SlyX Baculo_F PF12259.8 EEA21879.1 - 0.081 11.4 2.3 0.1 11.1 2.3 1.1 1 0 0 1 1 1 0 Baculovirus F protein UPF0242 PF06785.11 EEA21879.1 - 0.14 12.2 5.0 0.18 11.9 5.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 EEA21879.1 - 0.25 10.7 2.0 0.33 10.3 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) bZIP_2 PF07716.15 EEA21879.1 - 0.27 11.3 17.0 0.76 9.9 17.0 1.8 1 1 0 1 1 1 0 Basic region leucine zipper Fib_alpha PF08702.10 EEA21879.1 - 0.74 10.0 4.5 0.99 9.6 4.5 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 EEA21879.1 - 0.81 9.5 7.9 3.5 7.5 4.6 2.1 1 1 1 2 2 2 0 Septum formation initiator EMC3_TMCO1 PF01956.16 EEA21879.1 - 1.4 8.6 3.6 2.7 7.7 3.6 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like PAN_4 PF14295.6 EEA21880.1 - 8.5e-05 22.4 5.4 0.00022 21.0 5.4 1.7 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 EEA21880.1 - 0.00084 19.3 1.2 0.0037 17.2 1.2 2.1 1 0 0 1 1 1 1 PAN domain Abhydrolase_6 PF12697.7 EEA21881.1 - 2.7e-10 41.2 0.0 3.7e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA21881.1 - 1.1e-08 34.7 0.0 2.6e-08 33.4 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA21881.1 - 9.1e-06 25.5 0.5 4.6e-05 23.2 0.2 2.3 3 1 0 3 3 3 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA21881.1 - 0.0041 16.9 0.2 0.022 14.5 0.3 2.2 2 1 0 2 2 2 1 PGAP1-like protein Peptidase_S9 PF00326.21 EEA21881.1 - 0.0072 15.8 0.0 1.8 8.0 0.0 2.5 3 0 0 3 3 3 2 Prolyl oligopeptidase family ComK PF06338.11 EEA21881.1 - 0.081 12.6 0.3 1.6 8.3 0.1 2.2 2 0 0 2 2 2 0 ComK protein Abhydrolase_1 PF00561.20 EEA21882.1 - 9.5e-13 48.4 0.0 2.3e-10 40.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA21882.1 - 2.1e-09 38.3 0.0 2.6e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA21882.1 - 9.4e-08 31.6 0.0 7.5e-07 28.7 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EEA21882.1 - 3.9e-05 22.5 0.0 5.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Ndr family BAAT_C PF08840.11 EEA21882.1 - 0.034 14.1 0.0 0.87 9.5 0.0 2.4 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Epimerase PF01370.21 EEA21883.1 - 2.5e-17 63.2 0.0 3.8e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA21883.1 - 1.9e-08 34.1 0.0 3e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EEA21883.1 - 8.4e-06 25.1 0.0 1.2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EEA21883.1 - 5.4e-05 22.3 0.0 0.0001 21.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1175 PF06672.11 EEA21883.1 - 0.14 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1175) Aldose_epim PF01263.20 EEA21884.1 - 1.7e-39 135.9 0.1 2e-39 135.7 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Aldose_epim PF01263.20 EEA21885.1 - 1.7e-39 135.9 0.1 2e-39 135.7 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase MFS_1 PF07690.16 EEA21886.1 - 5.6e-27 94.6 18.9 5.6e-27 94.6 18.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA21886.1 - 0.00086 18.3 3.0 0.0016 17.4 3.0 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter UBA_4 PF14555.6 EEA21887.1 - 0.01 15.6 0.2 0.029 14.2 0.0 1.9 2 0 0 2 2 2 0 UBA-like domain DAHP_synth_2 PF01474.16 EEA21888.1 - 7.1e-202 670.7 0.0 8e-202 670.5 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family But2 PF09792.9 EEA21889.1 - 4.9e-52 176.1 3.3 9.7e-52 175.1 3.3 1.5 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain SGL PF08450.12 EEA21890.1 - 8e-68 228.7 0.1 1e-67 228.3 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Phosphodiest PF01663.22 EEA21890.1 - 0.026 14.1 0.1 0.036 13.7 0.1 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Arylesterase PF01731.20 EEA21890.1 - 0.034 14.3 0.0 0.069 13.3 0.0 1.5 1 0 0 1 1 1 0 Arylesterase Phytase-like PF13449.6 EEA21890.1 - 0.056 13.4 0.0 0.097 12.6 0.0 1.4 1 1 0 1 1 1 0 Esterase-like activity of phytase Reg_prop PF07494.11 EEA21890.1 - 0.29 11.5 1.5 36 5.1 0.1 2.8 2 0 0 2 2 2 0 Two component regulator propeller bZIP_2 PF07716.15 EEA21891.1 - 0.0028 17.7 9.5 0.0028 17.7 9.5 1.9 2 1 0 2 2 2 1 Basic region leucine zipper BSP_II PF05432.11 EEA21891.1 - 0.03 14.0 6.6 0.054 13.2 6.6 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Spt20 PF12090.8 EEA21891.1 - 1.1 8.8 13.5 2.5 7.7 13.5 1.7 1 0 0 1 1 1 0 Spt20 family His_Phos_2 PF00328.22 EEA21892.1 - 2.3e-59 201.7 0.0 2.7e-59 201.5 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Trypan_PARP PF05887.11 EEA21893.1 - 0.0014 18.6 13.8 0.0014 18.6 13.8 2.7 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) Ribophorin_II PF05817.14 EEA21894.1 - 1.8e-27 96.2 0.0 2.1e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF3561 PF12084.8 EEA21894.1 - 0.68 10.0 6.1 0.27 11.3 3.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3561) adh_short_C2 PF13561.6 EEA21896.1 - 2.9e-56 190.6 0.6 3.5e-56 190.4 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA21896.1 - 5.5e-46 156.5 2.2 6.8e-46 156.2 2.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA21896.1 - 9.1e-14 51.8 0.5 1.3e-13 51.2 0.5 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA21896.1 - 0.004 16.6 0.1 0.0056 16.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA21896.1 - 0.047 13.1 0.2 0.1 12.0 0.0 1.6 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase PLA2_B PF01735.18 EEA21897.1 - 7.2e-186 618.4 4.2 8.5e-186 618.1 4.2 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain PSD3 PF07626.11 EEA21897.1 - 0.12 12.9 0.2 23 5.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1587) Transp_cyt_pur PF02133.15 EEA21899.1 - 1.2e-102 344.0 43.9 1.3e-102 343.8 43.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Endothelin PF00322.17 EEA21899.1 - 0.45 10.2 2.9 0.53 9.9 1.0 2.2 1 1 0 1 1 1 0 Endothelin family DUF917 PF06032.12 EEA21900.1 - 1.1e-116 389.6 0.1 3e-116 388.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EEA21900.1 - 1.6e-28 99.8 6.2 8e-23 81.1 0.5 3.5 2 1 1 3 3 3 3 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EEA21900.1 - 3.1e-25 88.9 8.9 3.1e-24 85.7 0.1 3.6 4 0 0 4 4 4 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 EEA21900.1 - 0.00039 19.1 3.2 0.31 9.6 0.0 2.4 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.20 EEA21900.1 - 0.0061 16.1 0.5 0.0061 16.1 0.5 2.2 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 EEA21900.1 - 0.016 14.7 0.2 0.046 13.2 0.2 1.8 1 0 0 1 1 1 0 ROK family FtsA PF14450.6 EEA21900.1 - 6.3 7.3 6.4 8.6 6.8 0.7 3.5 4 2 0 4 4 4 0 Cell division protein FtsA Fungal_trans PF04082.18 EEA21901.1 - 2.7e-14 52.8 0.9 4.7e-14 52.1 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain 3Beta_HSD PF01073.19 EEA21901.1 - 7.7e-14 51.3 0.0 1.5e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA21901.1 - 4.7e-12 45.9 0.0 1.2e-11 44.6 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA21901.1 - 2.4e-09 37.3 0.0 4.3e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EEA21901.1 - 1.7e-07 30.7 0.0 0.0024 17.1 0.0 2.5 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EEA21901.1 - 5.1e-07 29.4 0.0 9.2e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Zn_clus PF00172.18 EEA21901.1 - 7.4e-07 29.2 10.5 1.5e-06 28.3 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NmrA PF05368.13 EEA21901.1 - 7.5e-07 28.9 0.0 1.6e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EEA21901.1 - 0.0018 17.5 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EEA21901.1 - 0.018 14.5 0.0 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Mac PF12464.8 EEA21902.1 - 3e-15 56.2 0.1 5.1e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 EEA21902.1 - 2.1e-14 52.6 6.3 1.1e-11 44.0 3.9 2.3 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EEA21902.1 - 1e-12 47.6 5.8 2e-09 37.0 4.1 2.3 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Beta-lactamase PF00144.24 EEA21903.1 - 1.1e-45 156.3 0.0 3.4e-45 154.7 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EEA21903.1 - 0.23 10.9 0.0 0.35 10.3 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Kelch_4 PF13418.6 EEA21904.1 - 1.4e-20 73.1 1.3 3.2e-08 33.5 0.0 4.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EEA21904.1 - 5.6e-16 57.9 0.9 5.1e-05 22.8 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EEA21904.1 - 2.5e-14 53.1 8.8 2.2e-09 37.4 0.0 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EEA21904.1 - 2e-13 50.1 9.8 2.6e-05 24.4 0.4 5.3 3 1 1 4 4 4 4 Kelch motif Kelch_5 PF13854.6 EEA21904.1 - 2.8e-11 43.1 6.2 4.7e-05 23.3 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EEA21904.1 - 7.8e-11 41.5 3.2 0.00052 19.9 0.0 4.1 4 0 0 4 4 4 3 Kelch motif Fungal_trans_2 PF11951.8 EEA21905.1 - 0.014 14.2 0.4 0.014 14.2 0.4 1.9 2 0 0 2 2 2 0 Fungal specific transcription factor domain AhpC-TSA PF00578.21 EEA21907.1 - 5.2e-31 107.1 0.0 8.8e-31 106.4 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EEA21907.1 - 6e-16 58.5 0.0 8.7e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EEA21907.1 - 5.5e-14 51.7 0.5 9e-14 51.0 0.5 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin MFS_1 PF07690.16 EEA21908.1 - 9.2e-40 136.6 28.6 9.2e-40 136.6 28.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA21908.1 - 2.8e-06 26.5 6.4 2.8e-06 26.5 6.4 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter EVE PF01878.18 EEA21909.1 - 5.6e-43 146.4 0.1 1.4e-42 145.1 0.1 1.7 1 0 0 1 1 1 1 EVE domain DUF3138 PF11336.8 EEA21909.1 - 3.1 6.3 4.8 5.1 5.6 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Methyltransf_PK PF05891.12 EEA21910.1 - 2.5e-68 229.8 0.0 2.2e-55 187.6 0.0 2.6 1 1 0 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.6 EEA21910.1 - 3.5e-09 36.7 0.0 7.2e-09 35.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA21910.1 - 0.00017 22.3 0.0 0.0016 19.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA21910.1 - 0.00032 21.3 0.0 0.0019 18.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA21910.1 - 0.0014 19.4 0.2 0.012 16.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Secretin_N_2 PF07655.13 EEA21910.1 - 0.049 14.2 1.7 9.5 6.8 1.1 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3069 PF11269.8 EEA21910.1 - 0.099 12.9 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) UDPGT PF00201.18 EEA21910.1 - 0.2 10.4 0.0 0.28 9.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase F-box-like PF12937.7 EEA21911.1 - 0.17 11.8 3.6 1.3 8.9 3.6 2.5 1 1 0 1 1 1 0 F-box-like CTP_transf_like PF01467.26 EEA21913.1 - 4.5e-08 33.4 0.0 3.6e-07 30.5 0.0 2.3 2 1 0 2 2 2 1 Cytidylyltransferase-like FAD_syn PF06574.12 EEA21913.1 - 0.042 13.8 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 FAD synthetase WD40 PF00400.32 EEA21914.1 - 1.4e-13 51.0 10.8 4.6e-06 27.3 0.3 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat Acyl_transf_3 PF01757.22 EEA21915.1 - 1.8e-35 122.7 36.2 2.4e-35 122.2 36.2 1.2 1 0 0 1 1 1 1 Acyltransferase family mRNA_triPase PF02940.15 EEA21916.1 - 2.1e-62 210.7 0.0 3.3e-62 210.1 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Spt5-NGN PF03439.13 EEA21917.1 - 3.5e-24 84.5 0.0 6.4e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section CTD PF12815.7 EEA21917.1 - 3.6e-18 65.9 54.5 1.2e-14 54.6 10.3 4.0 2 2 1 3 3 3 3 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 EEA21917.1 - 1.4e-17 64.5 8.8 1.4e-17 64.5 8.8 4.0 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 EEA21917.1 - 4.4e-11 42.3 13.0 0.00015 21.6 0.0 5.0 4 0 0 4 4 4 3 KOW motif DUF3912 PF13051.6 EEA21917.1 - 0.019 15.2 1.5 1.6 9.0 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3912) DUF2457 PF10446.9 EEA21917.1 - 0.31 10.1 33.1 0.64 9.1 33.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 EEA21917.1 - 1.2 8.5 29.5 2.3 7.5 29.5 1.4 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EEA21917.1 - 2.6 6.0 40.4 3.7 5.5 40.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ank_2 PF12796.7 EEA21918.1 - 1.5e-45 153.7 0.0 5.8e-17 62.1 0.0 4.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA21918.1 - 1.1e-31 108.8 0.0 1.6e-08 34.9 0.0 5.9 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA21918.1 - 1.9e-24 83.1 0.0 0.0069 16.8 0.0 8.2 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EEA21918.1 - 2.1e-23 81.7 0.0 0.041 14.3 0.0 7.4 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 EEA21918.1 - 4.3e-22 77.9 0.3 1.3e-05 25.4 0.0 6.9 2 2 5 7 7 7 5 Ankyrin repeats (many copies) F-box-like PF12937.7 EEA21918.1 - 1.9e-05 24.5 0.0 3.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 F-box-like VWA_3_C PF18571.1 EEA21918.1 - 0.083 12.8 4.7 1.2 9.1 0.0 4.6 7 0 0 7 7 7 0 von Willebrand factor type A C-terminal domain Acyl-CoA_dh_1 PF00441.24 EEA21919.1 - 3.1e-43 147.6 0.4 4.7e-43 147.0 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EEA21919.1 - 5.8e-23 80.9 0.2 1e-22 80.2 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EEA21919.1 - 4.9e-20 72.3 0.0 1.1e-19 71.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Cyt-b5 PF00173.28 EEA21919.1 - 3.5e-18 65.5 0.2 6.5e-18 64.6 0.2 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_2 PF08028.11 EEA21919.1 - 9.8e-12 45.3 0.0 1.7e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain RPN2_C PF18004.1 EEA21920.1 - 2e-55 187.1 9.1 2e-55 187.1 9.1 1.9 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EEA21920.1 - 1.2e-37 126.5 18.2 7.5e-10 38.7 0.0 8.8 8 0 0 8 8 8 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EEA21920.1 - 1.2e-22 80.1 0.2 2.7e-15 56.5 0.0 4.8 3 1 2 5 5 5 4 HEAT repeats HEAT_EZ PF13513.6 EEA21920.1 - 1.2e-07 32.0 0.1 0.0012 19.3 0.1 5.7 6 1 1 7 7 7 2 HEAT-like repeat HEAT PF02985.22 EEA21920.1 - 3e-06 27.0 0.0 4 7.9 0.0 5.8 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 EEA21920.1 - 9.2e-06 25.8 1.2 0.013 15.6 0.0 3.7 3 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 ANAPC3 PF12895.7 EEA21920.1 - 0.069 13.4 0.2 30 4.9 0.0 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 HEAT_PBS PF03130.16 EEA21920.1 - 0.19 12.5 2.9 1 10.2 0.0 3.6 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat Clathrin_H_link PF13838.6 EEA21920.1 - 1 9.3 3.0 1 9.3 0.1 2.4 3 0 0 3 3 3 0 Clathrin-H-link BST2 PF16716.5 EEA21921.1 - 0.0033 18.0 5.0 0.0033 18.0 5.0 3.0 3 0 0 3 3 3 1 Bone marrow stromal antigen 2 RPW8 PF05659.11 EEA21921.1 - 0.19 11.4 5.0 0.42 10.3 1.5 2.2 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Phage_GP20 PF06810.11 EEA21921.1 - 0.22 11.3 9.4 4.9 6.9 3.9 2.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 Syntaxin-6_N PF09177.11 EEA21921.1 - 0.37 11.4 4.9 7.1 7.3 0.2 3.8 2 2 0 2 2 2 0 Syntaxin 6, N-terminal RCR PF12273.8 EEA21922.1 - 0.0082 16.8 4.8 0.021 15.5 4.8 1.7 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red TAS2R PF05296.13 EEA21922.1 - 0.054 12.6 0.5 0.082 12.0 0.5 1.2 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) TMEM154 PF15102.6 EEA21922.1 - 0.084 12.8 0.2 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 TMEM154 protein family EphA2_TM PF14575.6 EEA21922.1 - 0.1 13.5 0.0 0.17 12.8 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Spt5_N PF11942.8 EEA21923.1 - 6.2 7.9 8.9 2.5 9.1 3.0 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal SKG6 PF08693.10 EEA21924.1 - 0.00012 21.4 3.3 0.00025 20.4 3.3 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Trp_oprn_chp PF09534.10 EEA21924.1 - 0.013 15.3 4.4 0.043 13.6 4.4 1.9 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Mid2 PF04478.12 EEA21924.1 - 0.017 14.9 0.2 0.085 12.7 0.0 2.2 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Peptidase_S49_N PF08496.10 EEA21924.1 - 0.04 14.0 0.2 0.069 13.2 0.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Insulin_TMD PF17870.1 EEA21924.1 - 0.053 13.6 1.4 0.1 12.7 1.4 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4834 PF16118.5 EEA21924.1 - 0.071 14.1 0.8 0.071 14.1 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF3188 PF11384.8 EEA21924.1 - 0.11 12.2 3.0 0.31 10.8 3.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Herpes_UL92 PF03048.14 EEA21924.1 - 0.11 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 UL92 family Gram_pos_anchor PF00746.21 EEA21924.1 - 0.13 12.2 1.4 0.25 11.3 1.4 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF5305 PF17231.2 EEA21924.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) TrbC PF04956.13 EEA21924.1 - 0.34 11.1 5.3 4.4 7.6 5.3 2.1 1 1 0 1 1 1 0 TrbC/VIRB2 family U3_snoRNA_assoc PF08297.11 EEA21924.1 - 0.72 10.6 5.3 0.57 10.9 1.7 2.2 2 0 0 2 2 2 0 U3 snoRNA associated EphA2_TM PF14575.6 EEA21924.1 - 0.77 10.7 5.4 2.8 8.9 3.5 2.7 3 1 0 3 3 2 0 Ephrin type-A receptor 2 transmembrane domain Podoplanin PF05808.11 EEA21924.1 - 0.83 9.7 4.1 0.37 10.9 0.2 2.2 3 0 0 3 3 3 0 Podoplanin Porph_ging PF09697.10 EEA21924.1 - 1.2 9.7 3.1 2.7 8.6 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) HemY_N PF07219.13 EEA21924.1 - 2.6 8.3 5.3 80 3.5 5.3 2.5 1 1 0 1 1 1 0 HemY protein N-terminus Ctr PF04145.15 EEA21924.1 - 4.6 7.8 5.4 11 6.6 5.4 1.8 1 1 0 1 1 1 0 Ctr copper transporter family PMI_typeI PF01238.21 EEA21925.1 - 2.5e-63 214.5 0.0 2e-61 208.3 0.0 2.0 1 1 0 1 1 1 1 Phosphomannose isomerase type I Glyco_hydro_35 PF01301.19 EEA21927.1 - 2e-86 290.5 2.0 3.8e-86 289.6 2.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EEA21927.1 - 4.3e-59 198.1 5.9 2.3e-34 118.4 0.1 3.0 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EEA21927.1 - 1.6e-55 187.7 0.2 2.7e-55 187.0 0.2 1.4 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EEA21927.1 - 6.4e-25 86.5 0.0 1.7e-24 85.1 0.0 1.8 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 Cellulase PF00150.18 EEA21927.1 - 1.1e-06 28.3 0.3 2e-06 27.4 0.3 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) GFO_IDH_MocA PF01408.22 EEA21928.1 - 1.1e-17 65.0 0.0 2.6e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EEA21928.1 - 0.015 16.0 0.1 0.027 15.1 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Zn_clus PF00172.18 EEA21929.1 - 2.2e-07 30.9 10.0 2.2e-07 30.9 10.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_processg_A PF02481.15 EEA21930.1 - 0.063 12.5 5.0 0.11 11.8 5.0 1.4 1 0 0 1 1 1 0 DNA recombination-mediator protein A Sugar_tr PF00083.24 EEA21931.1 - 2.3e-62 211.3 32.1 2.6e-62 211.2 32.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA21931.1 - 4.1e-25 88.4 35.8 5.6e-25 88.0 35.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hyd_65N_2 PF14498.6 EEA21932.1 - 3.2e-62 210.5 0.0 4.2e-62 210.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_1 PF00232.18 EEA21933.1 - 2.2e-143 478.0 2.7 2.7e-143 477.7 2.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 AA_permease_2 PF13520.6 EEA21934.1 - 4.6e-55 187.2 45.1 6.6e-55 186.6 45.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA21934.1 - 1.9e-32 112.5 31.8 1.9e-32 112.5 31.8 2.1 2 0 0 2 2 2 1 Amino acid permease MYO10_CC PF16735.5 EEA21934.1 - 0.16 12.1 0.2 0.24 11.5 0.2 1.2 1 0 0 1 1 1 0 Unconventional myosin-X coiled coil domain DUF4418 PF14387.6 EEA21935.1 - 0.015 15.5 3.3 0.015 15.5 3.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4418) DUF3810 PF12725.7 EEA21935.1 - 1.7 7.9 10.4 1.4 8.2 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Acetyltransf_10 PF13673.7 EEA21936.1 - 0.002 18.1 0.0 0.0036 17.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA21936.1 - 0.0045 17.2 0.0 0.0068 16.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA21936.1 - 0.026 15.0 0.0 0.042 14.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SGL PF08450.12 EEA21938.1 - 4.2e-67 226.3 1.3 4.9e-67 226.1 1.3 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EEA21938.1 - 0.0036 17.5 0.0 0.0091 16.2 0.0 1.7 1 0 0 1 1 1 1 Arylesterase Reg_prop PF07494.11 EEA21938.1 - 0.036 14.3 1.8 4 8.0 0.1 3.4 2 1 0 2 2 2 0 Two component regulator propeller Beta-lactamase PF00144.24 EEA21939.1 - 6.6e-74 249.1 0.1 7.5e-74 248.9 0.1 1.0 1 0 0 1 1 1 1 Beta-lactamase DDE_1 PF03184.19 EEA21940.1 - 1.1e-33 116.3 0.0 2.2e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA21940.1 - 3.5e-10 39.8 0.5 1.7e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA21940.1 - 2e-06 27.4 0.0 5.3e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-CCHC_2 PF13696.6 EEA21940.1 - 0.08 12.8 1.5 0.14 12.0 1.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EEA21940.1 - 0.34 11.0 2.1 0.62 10.3 2.1 1.4 1 0 0 1 1 1 0 Zinc knuckle ATP-synt_C PF00137.21 EEA21941.1 - 6.4e-09 36.0 12.5 1.3e-08 35.0 12.5 1.6 1 0 0 1 1 1 1 ATP synthase subunit C TetR_C_11 PF16859.5 EEA21941.1 - 0.18 12.1 4.0 5.5 7.3 2.5 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Glyco_transf_15 PF01793.16 EEA21942.1 - 4.9e-112 374.4 12.9 6.1e-112 374.1 12.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Imm17 PF15562.6 EEA21942.1 - 0.009 15.8 0.2 0.049 13.5 0.1 2.3 2 0 0 2 2 2 1 Immunity protein 17 Glyco_transf_15 PF01793.16 EEA21943.1 - 1.3e-111 373.0 13.0 1.5e-111 372.8 13.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase RabGAP-TBC PF00566.18 EEA21944.1 - 8.3e-32 110.6 0.0 1.3e-31 109.9 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 EEA21944.1 - 2.5e-07 29.4 2.1 2.5e-07 29.4 2.1 1.8 2 1 0 2 2 2 1 SBE2, cell-wall formation HhH-GPD PF00730.25 EEA21945.1 - 2.8e-07 31.0 0.0 4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Fungal_trans PF04082.18 EEA21946.1 - 2.3e-20 72.8 0.0 5.8e-20 71.4 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21946.1 - 5e-09 36.1 10.8 1.2e-08 35.0 10.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L37ae PF01780.19 EEA21947.1 - 2.4e-37 126.9 5.9 2.7e-37 126.7 5.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EEA21947.1 - 0.013 15.6 1.4 0.018 15.2 1.4 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-FCS PF06467.14 EEA21947.1 - 0.024 14.6 3.0 2.5 8.1 0.3 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn_Tnp_IS1595 PF12760.7 EEA21947.1 - 0.025 14.6 3.2 0.044 13.8 3.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 EEA21947.1 - 0.028 14.7 2.3 1.2 9.5 0.2 2.1 1 1 1 2 2 2 0 C1 domain DUF1451 PF07295.11 EEA21947.1 - 0.04 13.9 0.3 0.054 13.5 0.3 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain Elf1 PF05129.13 EEA21947.1 - 0.063 13.3 0.4 0.11 12.5 0.4 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 EEA21947.1 - 1.3 9.1 5.7 0.99 9.5 0.3 2.2 1 1 1 2 2 2 0 BED zinc finger Ribosomal_L37ae PF01780.19 EEA21948.1 - 2.4e-37 126.9 5.9 2.7e-37 126.7 5.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EEA21948.1 - 0.013 15.6 1.4 0.018 15.2 1.4 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-FCS PF06467.14 EEA21948.1 - 0.024 14.6 3.0 2.5 8.1 0.3 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn_Tnp_IS1595 PF12760.7 EEA21948.1 - 0.025 14.6 3.2 0.044 13.8 3.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 EEA21948.1 - 0.028 14.7 2.3 1.2 9.5 0.2 2.1 1 1 1 2 2 2 0 C1 domain DUF1451 PF07295.11 EEA21948.1 - 0.04 13.9 0.3 0.054 13.5 0.3 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain Elf1 PF05129.13 EEA21948.1 - 0.063 13.3 0.4 0.11 12.5 0.4 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 EEA21948.1 - 1.3 9.1 5.7 0.99 9.5 0.3 2.2 1 1 1 2 2 2 0 BED zinc finger Ribosomal_L37ae PF01780.19 EEA21949.1 - 2.4e-37 126.9 5.9 2.7e-37 126.7 5.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EEA21949.1 - 0.013 15.6 1.4 0.018 15.2 1.4 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-FCS PF06467.14 EEA21949.1 - 0.024 14.6 3.0 2.5 8.1 0.3 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn_Tnp_IS1595 PF12760.7 EEA21949.1 - 0.025 14.6 3.2 0.044 13.8 3.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 EEA21949.1 - 0.028 14.7 2.3 1.2 9.5 0.2 2.1 1 1 1 2 2 2 0 C1 domain DUF1451 PF07295.11 EEA21949.1 - 0.04 13.9 0.3 0.054 13.5 0.3 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain Elf1 PF05129.13 EEA21949.1 - 0.063 13.3 0.4 0.11 12.5 0.4 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 EEA21949.1 - 1.3 9.1 5.7 0.99 9.5 0.3 2.2 1 1 1 2 2 2 0 BED zinc finger Ribosomal_L37ae PF01780.19 EEA21950.1 - 2.4e-37 126.9 5.9 2.7e-37 126.7 5.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EEA21950.1 - 0.013 15.6 1.4 0.018 15.2 1.4 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-FCS PF06467.14 EEA21950.1 - 0.024 14.6 3.0 2.5 8.1 0.3 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn_Tnp_IS1595 PF12760.7 EEA21950.1 - 0.025 14.6 3.2 0.044 13.8 3.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 EEA21950.1 - 0.028 14.7 2.3 1.2 9.5 0.2 2.1 1 1 1 2 2 2 0 C1 domain DUF1451 PF07295.11 EEA21950.1 - 0.04 13.9 0.3 0.054 13.5 0.3 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain Elf1 PF05129.13 EEA21950.1 - 0.063 13.3 0.4 0.11 12.5 0.4 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 EEA21950.1 - 1.3 9.1 5.7 0.99 9.5 0.3 2.2 1 1 1 2 2 2 0 BED zinc finger Amidohydro_3 PF07969.11 EEA21951.1 - 5.8e-12 45.8 0.1 1.9e-07 31.0 0.0 2.6 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 EEA21951.1 - 5.4e-11 42.4 0.3 3e-08 33.4 0.0 2.9 3 0 0 3 3 3 2 Amidohydrolase family Cation_ATPase_C PF00689.21 EEA21952.1 - 2.8e-42 144.5 4.7 2.8e-42 144.5 4.7 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EEA21952.1 - 2.3e-37 128.3 3.2 2.3e-37 128.3 3.2 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EEA21952.1 - 1.6e-19 69.8 0.0 3e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EEA21952.1 - 2.7e-18 67.1 0.0 4.3e-09 37.0 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA21952.1 - 4.1e-13 48.8 0.0 1e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EEA21952.1 - 0.0047 16.7 0.3 0.0098 15.7 0.3 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 EEA21952.1 - 1.2 9.0 6.4 2.5 7.9 0.2 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) FtsK_4TM PF13491.6 EEA21952.1 - 8.3 6.1 8.9 2.5 7.8 0.9 3.1 3 0 0 3 3 3 0 4TM region of DNA translocase FtsK/SpoIIIE Pkinase PF00069.25 EEA21953.1 - 4.5e-44 150.8 0.0 7e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA21953.1 - 1.4e-23 83.5 0.1 6.5e-23 81.3 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA21953.1 - 6e-07 29.1 0.0 1.7e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA21953.1 - 0.0057 16.0 0.1 0.011 15.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_2 PF12796.7 EEA21954.1 - 2.7e-22 79.2 0.0 1.6e-08 35.0 0.1 5.3 3 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA21954.1 - 1.4e-15 57.4 0.1 2.8e-05 24.6 0.0 6.6 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA21954.1 - 1.2e-14 54.1 0.5 3.4e-06 27.2 0.1 4.9 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA21954.1 - 2.3e-10 40.5 4.0 0.0036 17.7 0.0 6.8 6 1 0 6 6 6 2 Ankyrin repeat Ank_3 PF13606.6 EEA21954.1 - 1.3e-09 37.5 0.0 0.053 14.1 0.0 7.6 7 0 0 7 7 7 1 Ankyrin repeat PNP_UDP_1 PF01048.20 EEA21954.1 - 7.3e-09 35.2 0.0 1.8e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily KAP_NTPase PF07693.14 EEA21954.1 - 0.0098 15.2 0.0 0.04 13.2 0.0 1.9 2 0 0 2 2 2 1 KAP family P-loop domain adh_short PF00106.25 EEA21955.1 - 2.1e-42 144.8 0.0 2.9e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21955.1 - 4e-33 114.9 0.0 6.3e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA21955.1 - 8.6e-06 25.8 0.0 0.00038 20.4 0.0 2.1 2 0 0 2 2 2 1 KR domain PP_kinase_C_1 PF17941.1 EEA21955.1 - 0.17 11.4 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 1 Asp PF00026.23 EEA21956.1 - 3.6e-63 213.9 2.4 4.7e-63 213.5 2.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA21956.1 - 1.1e-10 42.1 0.5 1.7e-06 28.4 0.1 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EEA21956.1 - 6.1e-07 29.4 0.0 2.4e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EEA21956.1 - 0.0052 17.4 0.8 4.2 8.1 0.0 3.6 3 0 0 3 3 3 2 Aspartyl protease SUR7 PF06687.12 EEA21957.1 - 2.1e-49 168.1 11.1 2.5e-49 167.8 11.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family OPT PF03169.15 EEA21957.1 - 0.00017 20.4 7.3 0.00027 19.7 7.3 1.3 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Clc-like PF07062.12 EEA21957.1 - 0.0048 16.4 1.7 0.0091 15.5 1.7 1.4 1 0 0 1 1 1 1 Clc-like DUF373 PF04123.13 EEA21957.1 - 0.05 13.0 1.8 0.073 12.5 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) WD40 PF00400.32 EEA21958.1 - 1.8e-14 53.8 27.3 2.4e-05 25.0 0.2 9.7 10 0 0 10 10 10 5 WD domain, G-beta repeat Phage_tail_3 PF08813.11 EEA21958.1 - 0.058 13.0 0.4 0.34 10.5 0.5 2.2 2 1 1 3 3 3 0 Phage tail tube protein, TTP FTR1 PF03239.14 EEA21959.1 - 1.2e-80 271.0 9.2 1.4e-80 270.7 9.2 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Phage_holin_3_6 PF07332.11 EEA21959.1 - 0.025 14.6 0.7 0.025 14.6 0.7 2.7 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III ESSS PF10183.9 EEA21959.1 - 1.1 9.6 4.1 11 6.3 0.3 3.1 2 1 1 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Wzy_C_2 PF11846.8 EEA21959.1 - 4.7 7.1 7.1 1.2 9.0 0.1 2.8 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal Cu-oxidase_2 PF07731.14 EEA21960.1 - 8.6e-47 158.3 7.2 1e-41 141.9 1.0 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EEA21960.1 - 3.5e-42 143.2 4.4 8.1e-39 132.3 0.7 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EEA21960.1 - 1.3e-40 139.2 2.0 2.5e-35 122.0 0.1 3.0 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EEA21960.1 - 0.00033 20.7 0.0 5 7.3 0.0 3.6 3 0 0 3 3 3 2 Cupredoxin-like domain Self-incomp_S1 PF05938.11 EEA21960.1 - 0.04 14.5 0.2 13 6.4 0.2 2.4 2 0 0 2 2 2 0 Plant self-incompatibility protein S1 Rad4 PF03835.15 EEA21961.1 - 2.7e-14 53.1 3.2 5.6e-14 52.1 3.2 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 EEA21961.1 - 5.3e-10 39.7 3.2 5.6e-10 39.7 1.8 1.8 2 0 0 2 2 2 1 Transglutaminase-like superfamily Glyco_transf_20 PF00982.21 EEA21962.1 - 7.1e-195 648.2 0.0 8.1e-195 648.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EEA21962.1 - 0.017 14.8 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EEA21962.1 - 0.2 11.2 0.4 18 4.8 0.1 2.6 2 1 0 2 2 2 0 Glycosyl transferases group 1 Glyco_transf_20 PF00982.21 EEA21963.1 - 4e-190 632.5 0.0 4.7e-190 632.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EEA21963.1 - 0.018 14.7 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EEA21963.1 - 0.23 11.0 0.4 20 4.7 0.1 2.6 2 1 0 2 2 2 0 Glycosyl transferases group 1 Glyco_transf_20 PF00982.21 EEA21964.1 - 4.9e-152 506.9 0.0 7.1e-152 506.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EEA21964.1 - 3.3e-34 118.0 0.0 6.4e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase DUF2487 PF10673.9 EEA21964.1 - 0.12 12.5 0.1 4.7 7.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2487) MBA1 PF07961.11 EEA21964.1 - 0.15 11.1 0.0 0.3 10.1 0.0 1.4 1 0 0 1 1 1 0 MBA1-like protein Oxidored_FMN PF00724.20 EEA21965.1 - 2.3e-98 329.6 0.0 2.6e-98 329.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Tautomerase PF01361.21 EEA21965.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Tautomerase enzyme WD40 PF00400.32 EEA21966.1 - 3.9e-18 65.5 14.1 0.00044 21.0 0.1 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA21966.1 - 8.3e-15 54.9 0.0 4.2e-05 23.8 0.0 5.1 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA21966.1 - 0.0002 21.3 0.3 0.023 14.6 0.0 2.8 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A HIRA_B PF09453.10 EEA21966.1 - 0.0038 17.0 0.2 0.015 15.2 0.2 2.1 1 0 0 1 1 1 1 HIRA B motif Ge1_WD40 PF16529.5 EEA21966.1 - 0.0069 15.4 0.1 7.1 5.5 0.0 3.3 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EEA21966.1 - 0.085 12.8 7.2 10 6.2 0.6 4.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat FYDLN_acid PF09538.10 EEA21966.1 - 7.2 7.3 0.0 7.2 7.3 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (FYDLN_acid) DUF3298 PF11738.8 EEA21967.1 - 1.2 10.2 3.5 20 6.3 0.2 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3298) Gpr1_Fun34_YaaH PF01184.19 EEA21969.1 - 1.6e-89 299.0 18.3 2e-89 298.7 18.3 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Fungal_trans_2 PF11951.8 EEA21970.1 - 1.3e-06 27.5 0.2 1.3e-06 27.5 0.2 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain SARAF PF06682.12 EEA21970.1 - 0.72 9.4 6.2 1.3 8.6 6.2 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Macoilin PF09726.9 EEA21970.1 - 1.2 7.6 7.8 2 6.9 7.8 1.3 1 0 0 1 1 1 0 Macoilin family adh_short PF00106.25 EEA21971.1 - 1.1e-28 100.0 0.0 1.4e-28 99.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA21971.1 - 1e-24 87.4 0.5 1.3e-24 87.1 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA21971.1 - 2.5e-08 34.1 0.1 3.8e-08 33.4 0.1 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA21971.1 - 2.8e-05 24.1 0.2 6.4e-05 22.9 0.1 1.9 1 1 1 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EEA21971.1 - 0.0013 18.2 0.1 0.0026 17.2 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EEA21971.1 - 0.0051 16.4 0.0 0.0079 15.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Isochorismatase PF00857.20 EEA21972.1 - 2.3e-21 76.8 0.0 2.6e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Isochorismatase PF00857.20 EEA21973.1 - 2.3e-21 76.8 0.0 2.6e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family ANTH PF07651.16 EEA21974.1 - 6.1e-64 215.7 0.5 7.7e-64 215.3 0.5 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EEA21974.1 - 8.2e-07 29.1 0.0 8.5e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 ENTH domain Ribosomal_S17_N PF16205.5 EEA21976.1 - 8.9e-33 112.5 0.4 1.4e-32 111.8 0.4 1.3 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EEA21976.1 - 1.2e-26 92.6 0.4 2.3e-26 91.7 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Spc7_N PF15402.6 EEA21977.1 - 0 1177.8 58.8 0 1176.9 58.8 1.5 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.11 EEA21977.1 - 6.1e-126 419.5 9.8 6.1e-126 419.5 9.8 2.2 4 0 0 4 4 4 1 Spc7 kinetochore protein PI3K_P85_iSH2 PF16454.5 EEA21977.1 - 0.32 10.6 13.5 0.045 13.3 4.5 3.5 3 1 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Fungal_trans PF04082.18 EEA21978.1 - 1.4e-19 70.1 0.2 3.2e-19 69.0 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 EEA21979.1 - 4e-17 62.1 1.0 7.7e-17 61.2 1.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA21979.1 - 3.4e-06 27.1 11.6 6.5e-06 26.2 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MRNIP PF15749.5 EEA21979.1 - 0.065 14.0 1.2 0.13 13.0 1.2 1.4 1 0 0 1 1 1 0 MRN-interacting protein Pox_A_type_inc PF04508.12 EEA21979.1 - 0.077 12.9 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DUF1932 PF09130.11 EEA21980.1 - 4.2e-22 77.9 0.1 1.9e-21 75.8 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1932) F420_oxidored PF03807.17 EEA21980.1 - 0.00097 19.7 0.0 0.0023 18.5 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EEA21980.1 - 0.0043 17.2 0.0 0.011 15.9 0.0 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EEA21980.1 - 0.03 13.7 0.0 0.069 12.5 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA21980.1 - 0.1 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain bZIP_2 PF07716.15 EEA21981.1 - 1.8e-10 40.8 9.4 1.8e-10 40.8 9.4 2.2 2 0 0 2 2 2 1 Basic region leucine zipper FPP PF05911.11 EEA21981.1 - 0.018 13.3 12.9 0.024 12.9 12.9 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil SidC_N PF18219.1 EEA21981.1 - 0.4 9.6 3.3 0.54 9.2 3.3 1.1 1 0 0 1 1 1 0 SidC N-terminal domain bZIP_1 PF00170.21 EEA21981.1 - 4.4 7.5 16.8 3.8 7.7 12.0 2.5 1 1 1 2 2 2 0 bZIP transcription factor Pil1 PF13805.6 EEA21982.1 - 5.1e-127 422.9 0.1 6.4e-127 422.5 0.1 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 XPG_N PF00752.17 EEA21983.1 - 2.4e-34 117.8 0.0 6.8e-34 116.4 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EEA21983.1 - 1.3e-25 89.6 0.1 2.2e-24 85.6 0.0 2.6 2 0 0 2 2 2 1 XPG I-region UIM PF02809.20 EEA21983.1 - 3.8e-05 23.3 0.3 3.8e-05 23.3 0.3 4.0 3 0 0 3 3 3 1 Ubiquitin interaction motif 5_3_exonuc PF01367.20 EEA21983.1 - 0.00011 22.7 0.0 0.00037 21.1 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 EEA21983.1 - 0.016 15.5 0.6 0.035 14.4 0.0 1.8 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family zf-C2H2_4 PF13894.6 EEA21984.1 - 0.077 13.9 12.9 0.4 11.6 0.2 4.1 3 1 0 3 3 3 0 C2H2-type zinc finger DUF1151 PF06625.11 EEA21984.1 - 1.9 8.5 14.5 0.29 11.1 4.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) PIP5K PF01504.18 EEA21986.1 - 1.2e-34 119.8 0.3 1.2e-25 90.3 0.4 2.6 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EEA21986.1 - 2.3e-28 99.1 0.0 4.1e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EEA21986.1 - 2e-15 56.7 4.0 2e-15 56.7 4.0 1.9 2 0 0 2 2 2 1 FYVE zinc finger C1_1 PF00130.22 EEA21986.1 - 0.0066 16.3 2.3 0.021 14.7 2.3 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PK PF00224.21 EEA21987.1 - 3.3e-176 585.3 3.9 4.4e-176 584.9 3.9 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EEA21987.1 - 1.1e-37 128.8 0.0 5.2e-37 126.7 0.0 2.1 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EEA21987.1 - 4.8e-05 22.6 0.3 0.00016 20.9 0.1 1.9 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 EEA21987.1 - 0.0094 15.0 0.1 0.083 11.9 0.0 2.1 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NTP_transf_2 PF01909.23 EEA21987.1 - 0.07 13.4 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF3506 PF12014.8 EEA21988.1 - 5.9e-51 172.1 0.0 1.1e-50 171.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) F-box-like PF12937.7 EEA21988.1 - 2.8e-10 39.9 1.8 5.7e-10 38.9 0.9 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EEA21988.1 - 2.9e-08 33.4 0.7 2.9e-08 33.4 0.7 1.8 2 0 0 2 2 2 1 F-box domain Elongin_A PF06881.11 EEA21988.1 - 0.0027 18.2 0.0 0.0052 17.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Csm1_N PF18504.1 EEA21989.1 - 0.0016 18.7 5.0 0.0016 18.7 5.0 4.5 3 1 0 3 3 3 1 Csm1 N-terminal domain ATG16 PF08614.11 EEA21989.1 - 0.012 15.9 9.8 0.012 15.9 9.8 5.7 4 2 2 6 6 6 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 EEA21989.1 - 0.013 15.5 12.8 0.013 15.5 12.8 4.8 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF948 PF06103.11 EEA21989.1 - 0.026 14.7 1.4 0.026 14.7 1.4 4.3 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) FAA_hydrolase_N PF09298.11 EEA21989.1 - 0.61 10.3 9.8 0.33 11.2 0.4 4.1 4 0 0 4 4 4 0 Fumarylacetoacetase N-terminal FPP PF05911.11 EEA21989.1 - 1.1 7.4 34.0 0.28 9.3 25.9 2.4 2 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil BAR_3 PF16746.5 EEA21989.1 - 2.7 7.6 25.8 0.2 11.3 9.4 3.2 2 1 1 3 3 3 0 BAR domain of APPL family Spc7 PF08317.11 EEA21989.1 - 3 6.6 40.8 0.61 8.9 16.8 3.7 3 1 1 4 4 4 0 Spc7 kinetochore protein GAS PF13851.6 EEA21989.1 - 3.2 7.0 48.4 0.35 10.2 0.2 4.3 3 2 1 4 4 4 0 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.12 EEA21989.1 - 5.5 7.5 17.3 1.4 9.4 0.7 4.4 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF1769 PF08588.10 EEA21990.1 - 4.6e-27 94.0 0.6 9.5e-27 93.0 0.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Iso_dh PF00180.20 EEA21991.1 - 5.1e-97 325.1 0.0 7.9e-97 324.5 0.0 1.3 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Peptidase_S58 PF03576.14 EEA21992.1 - 7.6e-99 331.0 1.8 8.7e-99 330.8 1.8 1.0 1 0 0 1 1 1 1 Peptidase family S58 DUF1455 PF07306.11 EEA21992.1 - 0.033 14.1 0.1 8.7 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1455) LIFR_D2 PF17971.1 EEA21994.1 - 0.024 14.9 0.0 0.033 14.4 0.0 1.2 1 0 0 1 1 1 0 Leukemia inhibitory factor receptor D2 domain AKNA PF12443.8 EEA21994.1 - 0.1 13.3 0.2 0.27 11.9 0.2 1.7 2 0 0 2 2 2 0 AT-hook-containing transcription factor PIN_8 PF18476.1 EEA21996.1 - 0.017 15.0 0.5 0.029 14.3 0.5 1.3 1 0 0 1 1 1 0 PIN like domain 3Beta_HSD PF01073.19 EEA21997.1 - 5.1e-47 160.2 0.0 2.1e-46 158.2 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA21997.1 - 9e-35 120.3 0.0 1.7e-34 119.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA21997.1 - 1.2e-17 64.4 0.0 3.3e-17 62.9 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EEA21997.1 - 3e-11 43.0 0.0 5e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EEA21997.1 - 8.4e-10 38.2 0.0 1.1e-07 31.3 0.0 2.6 2 0 0 2 2 2 1 Male sterility protein Zn_clus PF00172.18 EEA21997.1 - 3.3e-07 30.3 11.0 8e-07 29.1 11.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA21997.1 - 3.7e-07 29.5 1.4 1.7e-06 27.3 1.4 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain KR PF08659.10 EEA21997.1 - 2.1e-06 27.8 0.3 1.6e-05 24.9 0.3 2.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA21997.1 - 2.5e-06 27.5 0.0 4.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EEA21997.1 - 5.5e-06 25.7 0.5 1.2e-05 24.7 0.1 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EEA21997.1 - 0.00061 19.3 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 EEA21997.1 - 0.12 12.6 0.1 0.28 11.4 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EEA21998.1 - 1.4e-08 34.9 0.1 1.8e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA21998.1 - 9e-07 28.6 0.0 2.4e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family HIM1 PF08732.10 EEA21998.1 - 1.4e-05 24.7 0.0 2.6e-05 23.8 0.0 1.4 1 1 0 1 1 1 1 HIM1 NmrA PF05368.13 EEA21998.1 - 2.2e-05 24.1 0.6 0.00012 21.7 0.6 2.0 1 1 0 1 1 1 1 NmrA-like family CAP18_C PF12153.8 EEA21998.1 - 0.094 12.6 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) UVR PF02151.19 EEA21998.1 - 0.17 11.6 0.1 0.34 10.7 0.1 1.4 1 0 0 1 1 1 0 UvrB/uvrC motif RVT_1 PF00078.27 EEA21999.1 - 5.1e-30 104.6 0.0 1.1e-29 103.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA21999.1 - 1.3e-08 34.7 0.5 3.1e-08 33.5 0.5 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-RVT PF13966.6 EEA21999.1 - 0.011 16.4 0.0 0.043 14.5 0.0 2.1 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase zf-CCHC PF00098.23 EEA22000.1 - 0.00012 22.0 2.9 0.00012 22.0 2.9 2.8 2 0 0 2 2 2 1 Zinc knuckle BDV_P40 PF06407.11 EEA22000.1 - 0.0079 15.3 0.3 0.014 14.5 0.3 1.4 1 0 0 1 1 1 1 Borna disease virus P40 protein MPS2 PF17060.5 EEA22000.1 - 0.01 15.2 1.4 0.019 14.2 1.4 1.5 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF16 PF01519.16 EEA22000.1 - 0.014 15.8 6.2 0.014 15.8 6.2 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 EEA22000.1 - 0.02 15.5 6.0 0.02 15.5 6.0 2.5 3 0 0 3 3 3 0 SlyX HisKA_3 PF07730.13 EEA22000.1 - 0.068 13.7 4.7 8.6 7.0 0.7 3.6 3 0 0 3 3 3 0 Histidine kinase NPV_P10 PF05531.12 EEA22000.1 - 0.26 11.8 2.4 0.72 10.4 1.9 2.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein ApoO PF09769.9 EEA22000.1 - 0.83 9.6 4.1 0.71 9.8 1.1 2.5 2 1 1 3 3 3 0 Apolipoprotein O UPF0242 PF06785.11 EEA22000.1 - 6.5 6.8 13.5 2.6 8.1 7.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus MFS_1 PF07690.16 EEA22001.1 - 1.9e-27 96.1 64.9 9e-21 74.2 36.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribosomal_S8 PF00410.19 EEA22002.1 - 2.3e-10 40.5 0.0 2.9e-09 36.9 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein S8 FAD_binding_3 PF01494.19 EEA22004.1 - 6.8e-19 68.3 0.0 4.1e-18 65.8 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA22004.1 - 7.5e-05 22.1 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA22004.1 - 0.00089 19.8 0.1 0.055 14.0 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EEA22004.1 - 0.0017 17.7 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EEA22004.1 - 0.0024 17.5 0.1 0.0099 15.5 0.0 2.0 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA22004.1 - 0.0026 18.0 0.1 0.0068 16.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA22004.1 - 0.003 16.3 0.0 0.005 15.6 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EEA22004.1 - 0.0047 16.0 0.0 0.0084 15.2 0.0 1.4 1 1 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EEA22004.1 - 0.11 11.9 2.4 0.18 11.1 0.3 2.2 3 0 0 3 3 3 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EEA22004.1 - 0.11 11.3 0.0 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 EEA22004.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.10 EEA22004.1 - 0.14 11.2 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase ThiF PF00899.21 EEA22004.1 - 0.15 11.4 0.0 3.2 7.1 0.0 2.2 2 1 0 2 2 2 0 ThiF family Peptidase_M24 PF00557.24 EEA22005.1 - 1.2e-47 162.3 0.0 1.5e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EEA22005.1 - 6.7e-20 71.1 7.3 1.6e-19 69.9 7.3 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EEA22005.1 - 0.00062 19.8 5.2 0.00062 19.8 5.2 2.3 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EEA22005.1 - 0.24 11.3 3.3 0.57 10.1 3.3 1.7 1 0 0 1 1 1 0 HIT zinc finger Peptidase_M24 PF00557.24 EEA22006.1 - 1.1e-47 162.5 0.0 1.3e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EEA22006.1 - 6.2e-20 71.2 7.3 1.5e-19 70.0 7.3 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EEA22006.1 - 0.00058 19.9 5.2 0.00058 19.9 5.2 2.3 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EEA22006.1 - 0.22 11.4 3.3 0.54 10.2 3.3 1.7 1 0 0 1 1 1 0 HIT zinc finger MFS_1 PF07690.16 EEA22007.1 - 1.2e-45 156.0 58.9 2e-36 125.7 16.8 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA22007.1 - 5.2e-14 52.0 10.9 5.2e-14 52.0 10.9 3.3 3 1 1 4 4 4 2 Sugar (and other) transporter NTP_transf_6 PF06042.11 EEA22007.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase EF-hand_1 PF00036.32 EEA22008.1 - 1.8e-12 45.9 8.1 5.1e-05 22.5 1.0 3.7 3 0 0 3 3 3 2 EF hand ZZ PF00569.17 EEA22008.1 - 3.5e-11 42.7 6.4 5.8e-11 42.0 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_6 PF13405.6 EEA22008.1 - 2.7e-10 39.3 5.4 3.2e-05 23.5 0.2 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EEA22008.1 - 1e-09 38.7 0.6 8.8e-05 22.9 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA22008.1 - 0.00036 19.9 6.7 0.23 11.0 0.6 3.3 3 0 0 3 3 3 2 EF hand C1_2 PF03107.16 EEA22008.1 - 0.0014 18.9 4.5 0.0027 18.0 4.5 1.4 1 0 0 1 1 1 1 C1 domain EF-hand_8 PF13833.6 EEA22008.1 - 0.0048 16.7 5.4 0.31 10.9 0.5 3.4 3 0 0 3 3 3 2 EF-hand domain pair Dockerin_1 PF00404.18 EEA22008.1 - 0.045 14.0 0.1 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 Dockerin type I domain Sporozoite_P67 PF05642.11 EEA22008.1 - 0.54 8.3 3.4 1.1 7.2 3.4 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Epimerase PF01370.21 EEA22009.1 - 3.9e-08 33.1 0.0 0.0018 17.8 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA22009.1 - 0.0059 15.8 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EEA22009.1 - 0.019 14.8 0.0 0.038 13.9 0.0 1.5 2 0 0 2 2 2 0 NAD(P)H-binding Semialdhyde_dh PF01118.24 EEA22009.1 - 0.13 12.7 0.0 0.3 11.5 0.0 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 EEA22009.1 - 0.2 11.2 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family DUF1688 PF07958.11 EEA22010.1 - 1.4e-163 544.5 0.0 1.6e-163 544.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) RbpA PF13397.6 EEA22011.1 - 0.21 12.2 0.0 7.7 7.2 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase-binding protein WD40 PF00400.32 EEA22012.1 - 1.1e-30 105.2 6.2 3.3e-07 30.9 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA22012.1 - 2.5e-16 59.7 0.0 1e-05 25.7 0.0 4.7 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EEA22012.1 - 2.2e-05 24.2 0.0 5.8e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 PQQ-like domain PD40 PF07676.12 EEA22012.1 - 0.018 15.0 0.3 0.26 11.3 0.0 2.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EEA22012.1 - 0.032 14.1 0.2 2.3 8.1 0.0 3.0 2 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A DUF1513 PF07433.11 EEA22012.1 - 0.11 11.6 0.1 0.46 9.5 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1513) Ge1_WD40 PF16529.5 EEA22012.1 - 0.13 11.1 0.8 15 4.4 0.0 3.1 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cornichon PF03311.14 EEA22013.1 - 1.4e-48 164.2 12.6 1.6e-48 164.1 12.6 1.0 1 0 0 1 1 1 1 Cornichon protein Cornichon PF03311.14 EEA22014.1 - 1.4e-48 164.2 12.6 1.6e-48 164.1 12.6 1.0 1 0 0 1 1 1 1 Cornichon protein Cornichon PF03311.14 EEA22015.1 - 1.4e-48 164.2 12.6 1.6e-48 164.1 12.6 1.0 1 0 0 1 1 1 1 Cornichon protein Cornichon PF03311.14 EEA22016.1 - 1.4e-48 164.2 12.6 1.6e-48 164.1 12.6 1.0 1 0 0 1 1 1 1 Cornichon protein Cornichon PF03311.14 EEA22017.1 - 1.4e-48 164.2 12.6 1.6e-48 164.1 12.6 1.0 1 0 0 1 1 1 1 Cornichon protein ABC2_membrane PF01061.24 EEA22018.1 - 3.9e-39 134.2 19.9 7.3e-39 133.4 19.9 1.5 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EEA22018.1 - 3.1e-26 92.5 1.5 3.4e-26 92.4 0.1 1.8 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 EEA22018.1 - 2e-05 23.9 22.4 2e-05 23.9 22.4 2.1 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EEA22018.1 - 2.2e-05 24.4 0.4 0.12 12.2 0.0 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA22018.1 - 0.0022 17.7 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EEA22018.1 - 0.003 17.5 0.0 0.006 16.5 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EEA22018.1 - 0.0098 16.3 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EEA22018.1 - 0.015 15.8 0.1 0.054 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA22018.1 - 0.04 13.5 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 EEA22018.1 - 0.063 12.7 0.0 0.5 9.8 0.0 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain KCNQ2_u3 PF16642.5 EEA22018.1 - 0.11 13.5 1.6 0.23 12.5 1.6 1.5 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Aminotran_1_2 PF00155.21 EEA22019.1 - 2e-40 139.1 0.0 2.4e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EEA22019.1 - 4.6e-08 32.4 0.0 1.5e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EEA22019.1 - 4.6e-06 25.4 0.0 6.8e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EEA22019.1 - 3.2e-05 23.4 0.0 6.2e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Alliinase_C PF04864.13 EEA22019.1 - 0.0097 14.8 0.0 0.017 14.0 0.0 1.4 1 0 0 1 1 1 1 Allinase zf-C3HC PF07967.13 EEA22019.1 - 0.02 15.0 0.1 0.086 12.9 0.0 2.0 2 0 0 2 2 2 0 C3HC zinc finger-like AMP-binding PF00501.28 EEA22020.1 - 1.1e-66 225.2 0.0 1.5e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA22020.1 - 4.7e-11 43.5 0.0 2.4e-10 41.3 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain MaoC_dehydrat_N PF13452.6 EEA22021.1 - 0.056 13.6 0.0 1.8 8.7 0.0 2.4 2 1 0 2 2 2 0 N-terminal half of MaoC dehydratase Herpes_US9 PF06072.11 EEA22022.1 - 1.8 8.5 4.5 6.7 6.7 0.3 2.8 2 1 0 2 2 2 0 Alphaherpesvirus tegument protein US9 FAD_binding_4 PF01565.23 EEA22023.1 - 2.8e-21 75.7 3.4 3.9e-21 75.3 1.7 2.2 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EEA22023.1 - 9.9e-10 38.4 3.5 9.9e-10 38.4 3.5 1.9 2 0 0 2 2 2 1 Berberine and berberine like Fungal_trans PF04082.18 EEA22024.1 - 8.5e-11 41.4 0.1 1.7e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22024.1 - 1.8e-07 31.1 8.5 3.1e-07 30.4 8.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Serglycin PF04360.12 EEA22024.1 - 0.013 15.4 3.0 0.25 11.3 2.0 2.7 2 0 0 2 2 2 0 Serglycin HlyIII PF03006.20 EEA22025.1 - 3.1e-59 200.4 20.2 3.8e-59 200.1 20.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related FmiP_Thoc5 PF09766.9 EEA22026.1 - 5.7e-32 111.4 13.3 7.5e-32 111.0 13.3 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 SPATA1_C PF15743.5 EEA22026.1 - 0.0058 16.7 3.3 0.0058 16.7 3.3 2.2 2 1 0 2 2 2 1 Spermatogenesis-associated C-terminus DUF4200 PF13863.6 EEA22026.1 - 0.012 16.1 10.3 0.23 11.9 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Casc1_N PF15927.5 EEA22026.1 - 0.023 14.4 8.6 0.023 14.4 8.6 2.0 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus CwfJ_C_1 PF04677.15 EEA22026.1 - 0.21 11.5 1.1 2.8 7.8 0.1 2.2 1 1 1 2 2 2 0 Protein similar to CwfJ C-terminus 1 Mod_r PF07200.13 EEA22026.1 - 0.62 10.2 15.2 0.56 10.3 5.0 2.4 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF349 PF03993.12 EEA22026.1 - 0.73 10.2 9.0 0.36 11.2 6.2 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) DUF3450 PF11932.8 EEA22026.1 - 1.1 8.5 12.0 1.2 8.4 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF87 PF01935.17 EEA22026.1 - 1.9 8.5 5.1 3.6 7.6 5.1 1.6 1 1 0 1 1 1 0 Helicase HerA, central domain Flagellin_N PF00669.20 EEA22026.1 - 2.6 8.2 7.1 0.55 10.3 0.3 2.4 2 1 0 2 2 2 0 Bacterial flagellin N-terminal helical region YabA PF06156.13 EEA22026.1 - 2.7 8.7 7.4 10 6.8 1.9 2.3 2 0 0 2 2 2 0 Initiation control protein YabA FmiP_Thoc5 PF09766.9 EEA22027.1 - 1.1e-30 107.1 7.8 1.5e-30 106.8 7.8 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 DUF4200 PF13863.6 EEA22027.1 - 0.0043 17.4 9.3 0.14 12.6 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4200) SPATA1_C PF15743.5 EEA22027.1 - 0.013 15.6 4.2 0.013 15.6 4.2 2.1 2 0 0 2 2 2 0 Spermatogenesis-associated C-terminus Casc1_N PF15927.5 EEA22027.1 - 0.09 12.5 13.2 0.027 14.2 8.6 2.0 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus DUF349 PF03993.12 EEA22027.1 - 0.17 12.2 6.6 0.57 10.5 6.6 1.9 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Mod_r PF07200.13 EEA22027.1 - 0.91 9.6 14.8 0.65 10.1 5.0 2.4 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF3450 PF11932.8 EEA22027.1 - 1.6 8.0 12.0 1.5 8.1 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Flagellin_N PF00669.20 EEA22027.1 - 3.4 7.8 7.0 0.65 10.1 0.3 2.3 2 1 0 2 2 2 0 Bacterial flagellin N-terminal helical region YabA PF06156.13 EEA22027.1 - 3.7 8.3 7.3 12 6.6 1.9 2.3 2 0 0 2 2 2 0 Initiation control protein YabA PIG-S PF10510.9 EEA22028.1 - 9.7e-179 595.5 3.3 9.7e-179 595.5 3.3 1.4 2 0 0 2 2 2 1 Phosphatidylinositol-glycan biosynthesis class S protein DUF4512 PF14975.6 EEA22028.1 - 0.29 11.9 3.9 0.28 12.0 2.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4512) Sod_Fe_C PF02777.18 EEA22029.1 - 2e-17 63.2 0.0 3.8e-08 33.4 0.0 2.5 3 0 0 3 3 3 2 Iron/manganese superoxide dismutases, C-terminal domain Polyketide_cyc PF03364.20 EEA22030.1 - 8.8e-21 74.5 0.0 2e-20 73.3 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EEA22030.1 - 0.0027 18.0 0.0 0.0064 16.8 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Zn_clus PF00172.18 EEA22031.1 - 6.7e-07 29.3 7.3 1.7e-06 28.0 7.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UbiA PF01040.18 EEA22032.1 - 6.5e-17 61.7 12.8 9.5e-17 61.1 12.8 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Methyltransf_12 PF08242.12 EEA22033.1 - 3e-15 56.8 0.1 1.6e-14 54.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA22033.1 - 4e-14 53.1 0.0 1.6e-13 51.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA22033.1 - 9.2e-14 51.6 0.3 1.6e-13 50.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA22033.1 - 1.2e-12 48.3 0.1 8.1e-12 45.6 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA22033.1 - 8.9e-10 38.6 0.0 1.6e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA22033.1 - 1.5e-06 27.7 0.0 3.3e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EEA22033.1 - 0.00011 22.1 0.9 0.011 15.6 0.1 2.6 2 1 0 2 2 2 1 Hypothetical methyltransferase DUF3419 PF11899.8 EEA22033.1 - 0.00099 18.4 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) NNMT_PNMT_TEMT PF01234.17 EEA22033.1 - 0.001 18.3 0.0 0.12 11.5 0.0 2.4 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 EEA22033.1 - 0.0018 19.3 0.0 0.006 17.6 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EEA22033.1 - 0.002 18.2 0.2 0.066 13.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EEA22033.1 - 0.0097 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DUF3408 PF11888.8 EEA22033.1 - 0.75 9.9 9.6 0.18 11.9 6.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Fungal_trans PF04082.18 EEA22034.1 - 2.5e-17 62.8 0.8 4.5e-17 62.0 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain WBP-1 PF11669.8 EEA22035.1 - 0.034 14.8 4.5 0.86 10.3 0.2 3.0 3 0 0 3 3 3 0 WW domain-binding protein 1 UbiA PF01040.18 EEA22036.1 - 4e-55 186.9 22.3 5.7e-55 186.3 22.3 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family FTZ PF03867.14 EEA22036.1 - 0.13 11.8 0.2 0.19 11.2 0.2 1.3 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region PQ-loop PF04193.14 EEA22037.1 - 5.9e-21 74.0 4.5 1.2e-10 41.0 0.8 2.5 2 0 0 2 2 2 2 PQ loop repeat Med8 PF10232.9 EEA22038.1 - 1.9e-65 220.7 0.0 2.4e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Pox_Ag35 PF03286.14 EEA22038.1 - 0.088 12.6 1.5 0.11 12.2 0.7 1.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 EEA22038.1 - 0.14 12.5 8.2 0.31 11.5 8.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 EEA22038.1 - 0.23 10.6 5.9 0.29 10.3 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RNA_pol_3_Rpc31 PF11705.8 EEA22038.1 - 2.1 8.5 10.7 3 8.0 10.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 EEA22038.1 - 4.7 6.4 9.8 6.3 6.0 9.8 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EEA22038.1 - 8 4.4 9.0 14 3.6 9.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 EEA22038.1 - 8.7 6.2 9.6 17 5.2 9.6 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Abhydrolase_1 PF00561.20 EEA22039.1 - 4.5e-06 26.5 0.1 0.0092 15.6 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA22039.1 - 2.7e-05 24.9 0.0 3.9e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EEA22039.1 - 0.0026 17.4 0.1 0.0056 16.3 0.0 1.6 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EEA22039.1 - 0.0041 16.6 0.4 1.7 8.1 0.1 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA22039.1 - 0.005 16.1 0.0 0.05 12.9 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Roughex PF06020.11 EEA22039.1 - 0.081 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF1776 PF08643.10 EEA22039.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF3336 PF11815.8 EEA22040.1 - 7.1e-35 119.7 0.8 1.3e-34 118.8 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EEA22040.1 - 1.1e-18 68.2 0.0 2.5e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase Abhydrolase_6 PF12697.7 EEA22041.1 - 8.9e-13 49.3 0.0 2.5e-12 47.9 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA22041.1 - 1.3e-11 44.6 0.0 2.9e-11 43.5 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA22041.1 - 3e-07 30.0 0.0 6e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EEA22041.1 - 3.5e-05 22.7 0.0 0.0003 19.6 0.0 2.0 1 1 0 1 1 1 1 Ndr family Esterase PF00756.20 EEA22041.1 - 6.9e-05 22.6 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase EthD PF07110.11 EEA22041.1 - 0.00067 20.7 0.1 0.48 11.6 0.0 2.9 2 0 0 2 2 2 1 EthD domain zf-RVT PF13966.6 EEA22041.1 - 0.014 16.0 0.0 0.028 15.1 0.0 1.4 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase Abhydrolase_2 PF02230.16 EEA22041.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Alpha-amylase PF00128.24 EEA22046.1 - 2.1e-44 152.5 0.1 3.1e-44 151.9 0.1 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EEA22046.1 - 6.1e-24 84.1 0.0 1.2e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) UBA_6 PF18039.1 EEA22046.1 - 0.019 14.9 0.0 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 UBA-like domain UbiA PF01040.18 EEA22047.1 - 5.3e-27 94.7 15.6 7.9e-27 94.2 15.6 1.4 1 0 0 1 1 1 1 UbiA prenyltransferase family MFS_1 PF07690.16 EEA22048.1 - 4.1e-11 42.4 18.5 4.3e-10 39.1 10.6 2.5 3 0 0 3 3 3 2 Major Facilitator Superfamily DUF5345 PF17280.2 EEA22048.1 - 0.49 10.4 2.0 0.65 10.0 0.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Caveolin PF01146.17 EEA22048.1 - 4.9 7.1 10.0 2.1 8.3 0.2 2.8 2 1 0 2 2 2 0 Caveolin FAD_binding_3 PF01494.19 EEA22049.1 - 4e-08 32.9 0.0 1.3e-07 31.2 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EEA22049.1 - 2e-07 30.4 0.5 0.0004 19.6 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EEA22049.1 - 9.6e-07 28.3 0.8 0.0056 15.9 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA22049.1 - 2.9e-06 27.1 0.1 0.02 14.5 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA22049.1 - 1.4e-05 25.2 0.1 7.9e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA22049.1 - 0.00034 20.6 1.5 0.26 11.3 0.0 3.1 2 1 0 3 3 3 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EEA22049.1 - 0.0022 16.8 0.2 0.0044 15.8 0.2 1.5 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 EEA22049.1 - 0.0033 16.7 0.5 1.2 8.4 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA22049.1 - 0.0034 16.7 0.4 0.02 14.2 0.1 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EEA22049.1 - 0.0054 17.3 1.2 0.17 12.4 0.2 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA22049.1 - 0.016 14.4 0.1 0.028 13.6 0.1 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EEA22049.1 - 0.077 12.1 1.2 0.1 11.6 0.3 1.6 1 1 1 2 2 2 0 FAD binding domain zf-HYPF PF07503.12 EEA22049.1 - 0.22 11.3 1.6 0.38 10.6 1.6 1.3 1 0 0 1 1 1 0 HypF finger Fungal_trans PF04082.18 EEA22050.1 - 1.7e-17 63.4 0.1 3.7e-17 62.2 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22050.1 - 0.0011 19.1 12.5 0.0019 18.3 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FMO-like PF00743.19 EEA22051.1 - 5.7e-13 48.1 1.1 2.2e-09 36.3 0.1 2.8 2 1 0 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EEA22051.1 - 1.2e-11 44.7 0.7 3.5e-11 43.2 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA22051.1 - 1.4e-09 37.6 0.0 2e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA22051.1 - 2.1e-08 33.8 0.0 0.00072 18.9 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA22051.1 - 0.00097 18.4 0.1 0.0026 17.1 0.1 1.6 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EEA22051.1 - 0.002 18.1 0.7 0.67 9.9 0.0 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EEA22051.1 - 0.0022 17.2 0.2 0.048 12.8 0.0 2.8 2 1 2 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) Mqo PF06039.15 EEA22051.1 - 0.16 10.5 0.0 4.8 5.6 0.0 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) AA_permease PF00324.21 EEA22052.1 - 4.8e-112 375.0 42.5 5.9e-112 374.7 42.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA22052.1 - 1.4e-38 132.8 46.8 2.1e-38 132.2 46.8 1.2 1 0 0 1 1 1 1 Amino acid permease Aldo_ket_red PF00248.21 EEA22053.1 - 1.6e-53 181.9 0.0 1.8e-53 181.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3716 PF12511.8 EEA22055.1 - 7.6e-13 48.3 4.9 7.6e-13 48.3 4.9 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3716) NmrA PF05368.13 EEA22057.1 - 5.8e-61 206.0 0.4 7e-61 205.8 0.4 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA22057.1 - 3.4e-15 56.4 0.0 6e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EEA22057.1 - 0.00011 22.5 0.4 0.00069 19.9 0.3 2.2 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 EEA22057.1 - 0.00097 18.2 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA22057.1 - 0.0026 17.3 0.0 0.0037 16.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EEA22057.1 - 0.012 15.9 0.4 0.02 15.2 0.4 1.3 1 0 0 1 1 1 0 TrkA-N domain TMEM154 PF15102.6 EEA22058.1 - 5.2 7.0 8.6 0.36 10.7 1.6 2.1 2 0 0 2 2 2 0 TMEM154 protein family BTB PF00651.31 EEA22059.1 - 9.1e-07 29.1 0.0 0.0002 21.5 0.0 2.9 3 0 0 3 3 3 2 BTB/POZ domain CRIM PF16978.5 EEA22060.1 - 0.11 12.7 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), middle CRIM domain TEP1_N PF05386.11 EEA22061.1 - 0.075 12.6 0.1 0.4 10.3 0.0 2.0 2 0 0 2 2 2 0 TEP1 N-terminal domain Metallophos PF00149.28 EEA22062.1 - 6.1e-14 53.0 0.7 8.2e-14 52.6 0.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ADC PF06314.11 EEA22063.1 - 8.2e-06 25.5 0.0 1.5e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) SLATT_fungal PF18142.1 EEA22064.1 - 1.4e-28 99.3 0.0 2.7e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain Zn_clus PF00172.18 EEA22064.1 - 1.2e-09 38.2 6.5 1.9e-09 37.5 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain S1-like PF14444.6 EEA22064.1 - 0.078 12.9 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 S1-like Pex14_N PF04695.13 EEA22064.1 - 9.3 6.9 15.3 0.86 10.2 9.3 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MFS_1 PF07690.16 EEA22065.1 - 8.3e-26 90.7 42.1 8.3e-26 90.7 42.1 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily NmrA PF05368.13 EEA22066.1 - 5.7e-32 111.1 0.0 8.9e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA22066.1 - 1.8e-10 41.0 0.0 2.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Zn_clus PF00172.18 EEA22067.1 - 1e-06 28.7 8.3 1e-06 28.7 8.3 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Swi3 PF07962.12 EEA22067.1 - 0.0083 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 DUF4133 PF13571.6 EEA22068.1 - 4.4e-05 23.7 1.3 0.033 14.5 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4133) DUF4191 PF13829.6 EEA22068.1 - 0.00054 19.4 4.5 0.0063 15.9 0.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4191) Tfb4 PF03850.14 EEA22068.1 - 0.021 14.4 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Transcription factor Tfb4 TMEM132D_C PF15706.5 EEA22068.1 - 0.029 14.1 0.1 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF2207 PF09972.9 EEA22068.1 - 0.22 10.2 2.5 4.5 5.9 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) HET PF06985.11 EEA22069.1 - 4.1e-36 124.5 4.7 7.9e-36 123.6 4.0 1.9 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Glyco_hydro_17 PF00332.18 EEA22070.1 - 3.8e-07 30.0 1.1 5.3e-07 29.5 1.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 DUF3431 PF11913.8 EEA22071.1 - 8.1e-63 212.1 0.0 9.8e-63 211.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) TetR_C_14 PF17754.1 EEA22071.1 - 0.12 12.4 0.0 0.31 11.0 0.0 1.7 2 0 0 2 2 2 0 MftR C-terminal domain Acyl_transf_3 PF01757.22 EEA22072.1 - 6.9e-22 78.0 24.3 1.3e-21 77.0 23.7 1.8 1 1 0 1 1 1 1 Acyltransferase family Caps_synth_CapC PF14102.6 EEA22072.1 - 0.027 14.9 0.1 0.18 12.2 0.1 2.4 1 0 0 1 1 1 0 Capsule biosynthesis CapC Pal1 PF08316.11 EEA22073.1 - 1.5e-10 42.0 1.3 3.9e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 Pal1 cell morphology protein DUF2681 PF10883.8 EEA22073.1 - 0.21 12.0 3.1 14 6.2 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) HVSL PF09749.9 EEA22074.1 - 2.1e-85 286.0 0.1 2.5e-85 285.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF3807 PF12720.7 EEA22075.1 - 1.2e-37 129.9 10.5 1.5e-37 129.7 10.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) Med8 PF10232.9 EEA22075.1 - 0.012 15.2 2.3 0.016 14.8 2.3 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Epimerase PF01370.21 EEA22078.1 - 1.8e-06 27.6 0.0 2.5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA22078.1 - 4.2e-05 23.5 0.0 6.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EEA22078.1 - 0.078 13.4 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF1456 PF07308.13 EEA22078.1 - 0.094 13.1 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) PK_C PF02887.16 EEA22078.1 - 0.14 12.4 0.0 0.42 10.9 0.0 1.8 2 0 0 2 2 2 0 Pyruvate kinase, alpha/beta domain KR PF08659.10 EEA22078.1 - 0.14 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 KR domain NAD_binding_4 PF07993.12 EEA22078.1 - 0.19 10.9 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein bZIP_2 PF07716.15 EEA22079.1 - 0.0082 16.2 0.7 0.0082 16.2 0.7 3.7 4 0 0 4 4 4 1 Basic region leucine zipper bZIP_1 PF00170.21 EEA22079.1 - 0.026 14.6 0.2 0.026 14.6 0.2 3.3 3 0 0 3 3 3 0 bZIP transcription factor ATP-synt_E PF05680.12 EEA22079.1 - 0.5 10.7 4.1 0.82 10.0 0.3 2.8 2 0 0 2 2 2 0 ATP synthase E chain Cnn_1N PF07989.11 EEA22079.1 - 0.54 10.5 4.7 1.7 8.9 0.5 2.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 EEA22079.1 - 2 8.3 9.7 23 4.8 0.3 3.6 3 0 0 3 3 3 0 Septum formation initiator Shugoshin_N PF07558.11 EEA22079.1 - 2.5 8.0 5.5 5.4 7.0 0.1 3.0 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region ADIP PF11559.8 EEA22079.1 - 6.4 6.8 15.3 0.18 11.9 0.8 3.1 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding Fungal_trans PF04082.18 EEA22080.1 - 1.4e-07 30.8 0.4 4.1e-07 29.3 0.4 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22080.1 - 8e-07 29.1 9.8 8e-07 29.1 9.8 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DLH PF01738.18 EEA22081.1 - 3e-32 112.0 0.1 3.4e-32 111.7 0.1 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF915 PF06028.11 EEA22081.1 - 0.017 14.5 0.0 0.041 13.2 0.0 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 EEA22081.1 - 0.04 13.6 0.0 0.085 12.5 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold DJ-1_PfpI PF01965.24 EEA22082.1 - 1.8e-15 57.1 0.0 3.4e-15 56.2 0.0 1.4 1 1 0 1 1 1 1 DJ-1/PfpI family ABC_tran PF00005.27 EEA22083.1 - 8.4e-44 149.4 0.1 7e-21 75.2 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EEA22083.1 - 5e-31 108.4 20.0 6.2e-20 72.0 7.3 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA22083.1 - 1e-10 41.4 3.3 0.00079 18.9 0.9 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA22083.1 - 5.3e-08 33.0 2.8 0.044 13.6 0.0 4.2 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA22083.1 - 1.6e-07 30.9 3.9 0.0014 18.4 0.1 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EEA22083.1 - 6.9e-07 29.3 0.6 0.026 14.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EEA22083.1 - 2.1e-06 28.0 0.2 0.079 13.2 0.1 3.2 2 1 0 2 2 2 2 AAA domain DUF87 PF01935.17 EEA22083.1 - 2.5e-06 27.7 2.6 0.054 13.6 0.4 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 EEA22083.1 - 8.4e-06 24.9 0.7 0.062 12.2 0.0 2.5 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 EEA22083.1 - 1.1e-05 24.7 0.5 0.0082 15.2 0.1 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein SbcCD_C PF13558.6 EEA22083.1 - 1.3e-05 25.4 0.2 0.17 12.1 0.0 3.4 4 0 0 4 4 2 2 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 EEA22083.1 - 7.7e-05 22.3 0.2 0.28 10.7 0.1 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EEA22083.1 - 9.5e-05 21.9 4.1 0.079 12.3 0.1 2.6 3 0 0 3 3 2 2 FtsK/SpoIIIE family AAA_16 PF13191.6 EEA22083.1 - 9.6e-05 22.8 0.7 0.3 11.4 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EEA22083.1 - 0.00014 21.9 1.0 0.32 11.1 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EEA22083.1 - 0.00087 19.8 1.5 1.3 9.5 0.1 2.7 2 0 0 2 2 2 2 AAA domain cobW PF02492.19 EEA22083.1 - 0.002 17.8 1.0 0.25 10.9 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activat PF00158.26 EEA22083.1 - 0.0025 17.5 0.1 5.8 6.6 0.0 3.3 3 0 0 3 3 3 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EEA22083.1 - 0.0031 17.4 0.9 1.7 8.6 0.0 3.0 2 1 0 2 2 2 1 NTPase Zeta_toxin PF06414.12 EEA22083.1 - 0.0034 16.7 0.1 2.3 7.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_5 PF07728.14 EEA22083.1 - 0.0036 17.3 1.0 3 7.9 0.0 4.4 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EEA22083.1 - 0.0045 16.7 0.6 1.8 8.2 0.2 2.6 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EEA22083.1 - 0.0047 16.1 0.3 1.3 8.2 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EEA22083.1 - 0.0052 17.1 0.1 5.1 7.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 EEA22083.1 - 0.0065 17.0 0.1 2.6 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA22083.1 - 0.0077 16.4 0.1 2.3 8.4 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EEA22083.1 - 0.0097 15.5 0.2 0.11 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.7 EEA22083.1 - 0.012 14.6 0.6 0.44 9.4 0.1 2.5 2 0 0 2 2 2 0 AAA-like domain AAA_28 PF13521.6 EEA22083.1 - 0.022 15.0 1.8 1 9.6 0.3 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EEA22083.1 - 0.026 14.3 0.4 1 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 EEA22083.1 - 0.03 13.8 1.9 3.2 7.1 0.1 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein MobB PF03205.14 EEA22083.1 - 0.034 14.0 0.5 0.48 10.3 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.6 EEA22083.1 - 0.04 14.2 0.8 6.2 7.2 0.2 2.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EEA22083.1 - 0.043 13.7 4.2 4.8 7.1 0.1 3.1 3 0 0 3 3 3 0 NACHT domain IstB_IS21 PF01695.17 EEA22083.1 - 0.059 13.1 0.9 10 5.8 0.1 3.0 3 0 0 3 3 2 0 IstB-like ATP binding protein DUF2075 PF09848.9 EEA22083.1 - 0.082 12.1 3.3 0.59 9.3 0.2 2.9 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 EEA22083.1 - 0.083 12.6 0.5 5.8 6.6 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 EEA22083.1 - 0.096 12.4 1.1 10 5.9 0.1 2.7 2 1 0 2 2 2 0 DEAD/DEAH box helicase ATPase_2 PF01637.18 EEA22083.1 - 0.12 12.3 0.5 21 4.9 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 EEA22083.1 - 0.12 11.7 0.2 13 5.1 0.1 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.25 EEA22083.1 - 0.13 11.9 0.2 14 5.3 0.1 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain CbiA PF01656.23 EEA22083.1 - 0.19 11.8 0.0 0.19 11.8 0.0 1.9 2 0 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 EEA22083.1 - 1.5 9.2 5.2 5.8 7.4 0.4 3.8 3 2 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EEA22083.1 - 1.9 7.8 5.0 14 4.9 0.1 3.2 3 1 1 4 4 4 0 KaiC DDE_1 PF03184.19 EEA22084.1 - 3.8e-23 82.0 0.0 7.7e-23 81.0 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22084.1 - 8.5e-09 35.3 0.3 3.1e-08 33.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA22084.1 - 0.024 14.7 0.1 0.49 10.6 0.0 2.6 3 0 0 3 3 3 0 Transcription factor Pcc1 Amidase PF01425.21 EEA22084.1 - 0.21 10.5 1.1 0.32 9.9 1.1 1.2 1 0 0 1 1 1 0 Amidase Peptidase_S41 PF03572.18 EEA22085.1 - 8.2e-06 25.5 0.0 1.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S41 Methyltransf_31 PF13847.6 EEA22085.1 - 0.0021 17.9 0.1 0.004 16.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA22085.1 - 0.007 17.1 0.0 0.017 15.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EEA22085.1 - 0.05 12.9 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_3 PF01596.17 EEA22085.1 - 0.053 12.7 0.0 0.31 10.2 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase Ubie_methyltran PF01209.18 EEA22085.1 - 0.21 10.9 0.0 0.46 9.8 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family REV1_C PF16727.5 EEA22087.1 - 0.013 15.8 1.1 1.2 9.6 0.3 2.4 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA22087.1 - 0.056 13.3 1.1 0.19 11.5 0.3 1.9 1 1 1 2 2 2 0 Sulfotransferase domain RVT_2 PF07727.14 EEA22088.1 - 2.8e-38 132.0 0.2 5e-38 131.1 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA22088.1 - 1.7e-07 31.0 0.0 4.3e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA22088.1 - 0.00049 20.3 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA22088.1 - 0.023 14.2 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA22088.1 - 0.068 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA22088.1 - 0.1 12.9 3.2 0.27 11.5 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein ERO1 PF04137.15 EEA22089.1 - 1.6e-135 451.9 0.0 2e-135 451.6 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Peroxin-13_N PF04088.13 EEA22090.1 - 3.9e-53 179.6 0.1 5.5e-53 179.2 0.1 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EEA22090.1 - 2.6e-09 36.6 0.0 4.5e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EEA22090.1 - 2.9e-08 33.2 0.0 5.2e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain hSH3 PF14603.6 EEA22090.1 - 0.09 13.2 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain MFS_1 PF07690.16 EEA22091.1 - 3.8e-27 95.2 38.1 3.8e-27 95.2 38.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EEA22091.1 - 0.0005 19.5 21.3 0.0028 17.0 21.3 1.9 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Flavi_NS4A PF01350.17 EEA22091.1 - 1.5 8.8 6.5 0.84 9.6 1.3 2.8 2 1 0 3 3 3 0 Flavivirus non-structural protein NS4A APG6 PF04111.12 EEA22093.1 - 6.6e-74 247.7 0.0 9.3e-74 247.2 0.0 1.2 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EEA22093.1 - 9.2e-41 139.5 13.4 1.6e-40 138.7 13.4 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region KASH_CCD PF14662.6 EEA22093.1 - 0.05 13.4 8.7 0.08 12.8 8.7 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Lge1 PF11488.8 EEA22093.1 - 0.66 10.2 8.2 1.8 8.8 7.1 2.3 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 CENP-H PF05837.12 EEA22093.1 - 0.73 10.3 4.6 2.2 8.7 4.6 1.9 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Jnk-SapK_ap_N PF09744.9 EEA22093.1 - 4.2 7.6 14.2 49 4.1 12.9 2.7 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 EEA22093.1 - 5.6 7.1 17.5 0.19 11.9 10.7 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) bZIP_2 PF07716.15 EEA22093.1 - 7 6.8 7.6 16 5.7 7.6 1.6 1 0 0 1 1 1 0 Basic region leucine zipper Scm3 PF10384.9 EEA22094.1 - 1.1e-19 69.8 0.4 2.9e-19 68.6 0.4 1.8 1 0 0 1 1 1 1 Centromere protein Scm3 PALP PF00291.25 EEA22095.1 - 8.8e-62 209.2 0.1 1.3e-61 208.7 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.17 EEA22096.1 - 4.8e-42 144.4 0.0 6.9e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 EEA22096.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase PX PF00787.24 EEA22099.1 - 4.3e-16 58.9 0.0 6.8e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 PX domain IQ PF00612.27 EEA22100.1 - 3.4e-05 23.2 1.5 0.0001 21.8 1.5 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif UPF0767 PF15990.5 EEA22100.1 - 0.12 12.6 0.6 0.56 10.4 0.6 2.2 1 0 0 1 1 1 0 UPF0767 family mono-CXXC PF15626.6 EEA22100.1 - 0.16 12.4 1.1 0.42 11.0 0.0 2.3 2 0 0 2 2 2 0 single CXXC unit DUF4611 PF15387.6 EEA22100.1 - 0.18 12.0 26.5 0.038 14.2 4.3 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) RXT2_N PF08595.11 EEA22100.1 - 5.3 7.1 21.7 0.17 11.9 2.5 3.5 3 0 0 3 3 3 0 RXT2-like, N-terminal MFS_1 PF07690.16 EEA22101.1 - 1.5e-36 126.1 32.7 2.4e-36 125.4 32.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA22101.1 - 6.8e-08 32.2 4.9 6.8e-08 32.2 4.9 2.3 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 EEA22101.1 - 2.1e-06 26.9 16.0 0.0022 16.9 8.1 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 EEA22101.1 - 0.00076 18.4 8.3 0.0012 17.8 8.3 1.4 1 0 0 1 1 1 1 MFS_1 like family Spectrin_like PF18373.1 EEA22101.1 - 0.082 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Spectrin like domain Transferase PF02458.15 EEA22102.1 - 0.0027 16.4 0.0 0.038 12.7 0.0 2.1 1 1 0 1 1 1 1 Transferase family Cupin_1 PF00190.22 EEA22103.1 - 2.8e-36 124.4 0.0 2.3e-18 66.2 0.0 2.3 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EEA22103.1 - 2.3e-21 75.2 0.3 1.9e-11 43.5 0.0 2.7 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EEA22103.1 - 4.7e-07 29.4 0.0 0.005 16.5 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 EEA22103.1 - 0.0012 18.7 0.1 1.5 8.8 0.0 2.6 2 0 0 2 2 2 2 AraC-like ligand binding domain Zn_clus PF00172.18 EEA22103.1 - 0.0022 18.1 3.9 0.0037 17.4 3.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA22103.1 - 0.062 12.1 0.1 0.084 11.7 0.1 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF1275 PF06912.11 EEA22104.1 - 8.9e-45 153.0 11.1 1.1e-44 152.7 11.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) 7TMR-DISM_7TM PF07695.11 EEA22104.1 - 0.4 10.6 4.4 0.13 12.1 0.7 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling Asp PF00026.23 EEA22105.1 - 2.1e-46 158.8 0.0 2.4e-46 158.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA22105.1 - 0.02 15.5 0.1 12 6.6 0.0 3.4 4 0 0 4 4 4 0 Aspartyl protease RVT_1 PF00078.27 EEA22106.1 - 1.9e-35 122.4 0.0 2.8e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EEA22106.1 - 8.6e-11 42.2 0.0 1.8e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 EEA22106.1 - 2.2e-05 25.1 0.0 6.5e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_3 PF13456.6 EEA22106.1 - 0.08 12.8 0.2 0.3 10.9 0.0 2.1 3 0 0 3 3 3 0 Reverse transcriptase-like Ank_2 PF12796.7 EEA22109.1 - 5.4e-31 107.0 2.4 2.4e-09 37.6 0.4 4.9 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA22109.1 - 9.4e-27 93.0 1.3 0.00046 20.7 0.0 7.6 5 1 2 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA22109.1 - 6.8e-21 74.1 8.3 5e-06 26.7 0.2 6.9 6 1 2 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA22109.1 - 3e-20 70.2 10.9 0.00054 20.2 0.4 10.4 11 0 0 11 11 11 4 Ankyrin repeat Ank PF00023.30 EEA22109.1 - 1.2e-16 60.2 19.4 4.3e-05 23.8 0.9 9.2 9 1 0 9 9 9 5 Ankyrin repeat PRANC PF09372.10 EEA22109.1 - 0.015 15.6 0.8 0.033 14.5 0.1 1.9 2 0 0 2 2 2 0 PRANC domain Ank_2 PF12796.7 EEA22110.1 - 2.2e-31 108.2 6.7 5.5e-07 30.1 0.2 6.4 5 1 1 7 7 7 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA22110.1 - 1.6e-22 79.2 9.8 0.00097 19.4 0.1 7.0 6 1 1 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EEA22110.1 - 3.9e-22 77.7 19.6 1.5e-05 25.2 0.1 10.0 10 1 1 11 11 11 6 Ankyrin repeat Ank_4 PF13637.6 EEA22110.1 - 4.4e-21 75.0 13.9 9.6e-05 22.9 0.0 8.8 7 3 3 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA22110.1 - 2.1e-20 70.6 14.7 0.0005 20.3 0.0 12.1 13 0 0 13 13 13 3 Ankyrin repeat DOPA_dioxygen PF08883.11 EEA22111.1 - 0.19 11.9 0.4 15 5.8 0.0 2.2 2 0 0 2 2 2 0 Dopa 4,5-dioxygenase family Methyltransf_31 PF13847.6 EEA22112.1 - 0.0024 17.7 0.0 0.0037 17.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA22112.1 - 0.13 13.0 0.0 0.21 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF4690 PF15756.5 EEA22113.1 - 0.00026 21.5 2.0 0.00045 20.8 2.0 1.4 1 0 0 1 1 1 1 Small Novel Rich in Cartilage PTP_tm PF18861.1 EEA22113.1 - 0.11 12.5 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DDE_3 PF13358.6 EEA22114.1 - 7e-13 48.6 0.1 2e-12 47.1 0.1 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA22114.1 - 7e-10 39.0 0.5 1.6e-09 37.9 0.5 1.6 1 0 0 1 1 1 1 Transposase HTH_12 PF08461.10 EEA22114.1 - 0.0082 16.1 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_32 PF13565.6 EEA22114.1 - 0.12 13.0 0.6 0.12 13.0 0.6 3.6 2 1 2 4 4 4 0 Homeodomain-like domain NTase_sub_bind PF08780.11 EEA22114.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like Fungal_trans PF04082.18 EEA22116.1 - 8.2e-17 61.1 0.2 1.9e-16 59.9 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Sulfatase PF00884.23 EEA22117.1 - 1.3e-126 422.2 0.1 9.2e-65 219.0 0.0 2.1 2 0 0 2 2 2 2 Sulfatase DUF4976 PF16347.5 EEA22117.1 - 1.7e-22 79.6 6.2 2.7e-19 69.3 1.6 3.4 3 1 0 3 3 3 2 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EEA22117.1 - 6.9e-08 32.5 0.3 0.1 12.2 0.0 4.1 4 0 0 4 4 4 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 EEA22117.1 - 0.0024 18.6 1.0 1.3 9.8 0.0 3.3 2 1 0 2 2 2 1 C-terminal region of aryl-sulfatase DUF229 PF02995.17 EEA22117.1 - 0.015 14.0 0.0 4.3 5.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF229) DUF4994 PF16385.5 EEA22117.1 - 0.081 12.8 0.1 0.69 9.9 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function Sugar_tr PF00083.24 EEA22118.1 - 1.3e-77 261.6 19.9 1.5e-77 261.4 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA22118.1 - 1.9e-13 50.1 18.0 1.9e-13 50.1 18.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA22118.1 - 2.4e-10 39.5 2.8 3.9e-10 38.8 2.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_2 PF04550.12 EEA22118.1 - 0.66 10.6 5.5 0.37 11.4 2.7 2.0 2 0 0 2 2 2 0 Phage holin family 2 DUF4231 PF14015.6 EEA22119.1 - 0.0097 16.4 2.5 0.023 15.2 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF4231) LRR19-TM PF15176.6 EEA22119.1 - 0.07 13.1 0.5 0.2 11.6 0.1 2.0 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Trp_oprn_chp PF09534.10 EEA22119.1 - 0.19 11.5 3.5 0.62 9.8 0.2 2.8 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Lung_7-TM_R PF06814.13 EEA22119.1 - 0.64 9.2 10.8 0.013 14.7 3.2 2.0 3 0 0 3 3 3 0 Lung seven transmembrane receptor DUF1345 PF07077.11 EEA22119.1 - 2.9 7.5 16.1 0.087 12.5 4.4 3.1 4 1 0 4 4 4 0 Protein of unknown function (DUF1345) Glyco_hydro_18 PF00704.28 EEA22120.1 - 2e-19 70.5 0.6 5.3e-19 69.1 0.6 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DUF167 PF02594.16 EEA22121.1 - 9.8e-16 57.6 0.0 1.6e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 YgbB PF02542.16 EEA22121.1 - 0.051 13.9 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 YgbB family DUF4862 PF16154.5 EEA22121.1 - 0.098 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4862) Tautomerase_2 PF14552.6 EEA22121.1 - 0.14 12.3 0.0 0.47 10.6 0.0 1.8 1 1 1 2 2 2 0 Tautomerase enzyme FMO-like PF00743.19 EEA22122.1 - 8.6e-93 311.6 0.0 1.1e-92 311.3 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA22122.1 - 3.6e-20 72.4 0.0 3.9e-15 55.9 0.0 3.4 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA22122.1 - 5.1e-12 45.6 0.0 2.5e-09 36.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA22122.1 - 1.2e-08 34.5 0.0 3.5e-06 26.4 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EEA22122.1 - 3.5e-08 33.6 0.0 8.6e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA22122.1 - 5.4e-06 26.5 0.1 0.033 14.2 0.0 3.6 3 1 0 3 3 3 2 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EEA22122.1 - 0.00013 21.4 0.0 0.00053 19.4 0.0 1.9 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.24 EEA22122.1 - 0.00035 20.3 0.7 0.0042 16.7 0.2 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA22122.1 - 0.00044 20.7 0.0 1.3 9.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA22122.1 - 0.0029 16.7 0.0 0.0048 16.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EEA22122.1 - 0.019 13.7 0.0 0.11 11.2 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 EEA22122.1 - 0.025 13.8 0.1 0.36 10.0 0.0 2.3 2 0 0 2 2 2 0 Thi4 family FAD_oxidored PF12831.7 EEA22122.1 - 0.039 13.3 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase MFS_1 PF07690.16 EEA22123.1 - 1.2e-33 116.5 23.7 1.2e-33 116.5 23.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 EEA22123.1 - 2.2 8.6 7.8 1.7 9.0 1.6 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) DUF2681 PF10883.8 EEA22123.1 - 7.7 7.0 6.5 0.61 10.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Peptidase_S9 PF00326.21 EEA22125.1 - 4.5e-48 163.5 0.1 1.5e-47 161.8 0.1 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 EEA22125.1 - 0.0022 16.7 0.0 0.4 9.3 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) PD40 PF07676.12 EEA22125.1 - 0.025 14.5 0.0 0.91 9.5 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Sec63 PF02889.16 EEA22126.1 - 6.1e-165 546.6 0.1 5.4e-93 310.9 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EEA22126.1 - 7.2e-50 169.2 0.1 2.5e-28 99.0 0.0 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EEA22126.1 - 1.3e-28 99.3 0.5 3.8e-28 97.9 0.5 1.8 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 EEA22126.1 - 3.5e-23 82.5 0.0 5.8e-13 49.2 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA22126.1 - 2.4e-11 44.0 0.0 7.7e-08 32.7 0.0 3.7 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EEA22126.1 - 1.6e-06 28.5 0.9 0.017 15.4 0.1 3.8 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EEA22126.1 - 1.4e-05 24.9 0.0 0.0024 17.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA22126.1 - 0.00092 19.6 0.0 1.4 9.3 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain PhoH PF02562.16 EEA22126.1 - 0.0021 17.5 0.0 0.16 11.4 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.6 EEA22126.1 - 0.0046 17.3 0.0 3.5 7.9 0.0 2.8 2 1 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 EEA22126.1 - 0.019 14.5 0.0 1.5 8.2 0.0 2.6 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain T2SSE PF00437.20 EEA22126.1 - 0.047 12.8 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein MutS_V PF00488.21 EEA22127.1 - 2.1e-73 246.4 0.0 4.5e-73 245.3 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EEA22127.1 - 6.9e-44 150.4 6.5 1.6e-43 149.2 6.5 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EEA22127.1 - 1.5e-20 73.5 0.0 4e-20 72.1 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EEA22127.1 - 3e-06 27.6 0.0 8.6e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EEA22127.1 - 0.07 13.5 0.1 0.18 12.2 0.1 1.8 1 0 0 1 1 1 0 MutS family domain IV AAA_28 PF13521.6 EEA22127.1 - 0.14 12.4 1.2 2.3 8.5 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_23 PF13476.6 EEA22127.1 - 0.39 11.2 4.1 3.8 8.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain DUF2312 PF10073.9 EEA22127.1 - 0.91 9.2 5.1 1.1 9.0 0.8 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Ureidogly_lyase PF04115.12 EEA22128.1 - 8.1e-61 205.1 0.0 3.3e-29 102.0 0.0 2.2 2 0 0 2 2 2 2 Ureidoglycolate lyase SGL PF08450.12 EEA22129.1 - 1.8e-27 96.5 0.0 3.3e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Zn_clus PF00172.18 EEA22129.1 - 3.2e-06 27.2 5.0 8.5e-06 25.8 5.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA22129.1 - 6.5e-06 25.4 0.0 2.6e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Arylesterase PF01731.20 EEA22129.1 - 1.2e-05 25.4 0.0 5e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Arylesterase Str_synth PF03088.16 EEA22129.1 - 0.00012 22.1 0.0 0.00035 20.6 0.0 1.8 1 0 0 1 1 1 1 Strictosidine synthase SBP_bac_11 PF13531.6 EEA22130.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.6 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein AMP-binding PF00501.28 EEA22131.1 - 2e-82 277.1 0.0 1.1e-81 274.7 0.0 1.8 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA22131.1 - 7.4e-14 52.5 0.1 1.8e-13 51.2 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fungal_trans PF04082.18 EEA22132.1 - 3.5e-23 82.0 0.4 7.9e-23 80.8 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Chitin_bind_1 PF00187.19 EEA22133.1 - 1.9e-13 50.6 77.7 3.8e-05 24.1 18.5 4.0 3 1 1 4 4 4 3 Chitin recognition protein Syndecan PF01034.20 EEA22133.1 - 0.2 11.6 0.0 0.34 10.9 0.0 1.2 1 0 0 1 1 1 0 Syndecan domain Glyco_transf_28 PF03033.20 EEA22134.1 - 6.9e-17 61.8 0.2 1.3e-11 44.7 0.0 2.5 2 0 0 2 2 2 2 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EEA22134.1 - 1.3e-05 24.2 0.0 2.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 EEA22134.1 - 0.00015 22.0 0.0 0.00088 19.6 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain UIM PF02809.20 EEA22134.1 - 0.00065 19.4 2.4 0.0017 18.1 2.4 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif Glyco_tran_28_C PF04101.16 EEA22134.1 - 0.01 15.9 0.1 0.031 14.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain MARVEL PF01284.23 EEA22135.1 - 6.2e-23 81.4 9.3 7.6e-23 81.1 9.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain Tim17 PF02466.19 EEA22139.1 - 7.4e-12 45.6 1.0 1.2e-11 45.0 1.0 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Brix PF04427.18 EEA22140.1 - 7.5e-33 114.3 0.0 1e-32 113.8 0.0 1.2 1 0 0 1 1 1 1 Brix domain NUP50 PF08911.11 EEA22140.1 - 0.11 13.2 0.4 0.29 11.8 0.4 1.8 1 1 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) RNase_P_p30 PF01876.16 EEA22142.1 - 2.1e-66 223.5 0.0 3e-66 223.0 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Pkinase PF00069.25 EEA22143.1 - 1.1e-64 218.3 0.2 1.3e-64 218.1 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22143.1 - 2.6e-19 69.5 0.0 3.8e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA22143.1 - 9.5e-08 32.3 0.0 6e-05 23.1 0.2 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EEA22143.1 - 0.0036 16.2 0.0 0.0069 15.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EEA22143.1 - 0.0075 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA22143.1 - 0.024 14.0 0.1 0.039 13.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EEA22143.1 - 0.066 12.8 0.1 0.066 12.8 0.1 2.0 3 0 0 3 3 3 0 Choline/ethanolamine kinase tRNA-synt_1 PF00133.22 EEA22144.1 - 1.2e-216 720.7 0.5 1.2e-216 720.7 0.5 2.3 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EEA22144.1 - 6.8e-34 117.0 1.7 6.8e-34 117.0 1.7 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EEA22144.1 - 2.2e-15 56.3 3.6 6.2e-07 28.5 0.1 4.4 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EEA22144.1 - 2.8e-09 36.7 2.1 2.1e-06 27.4 0.0 2.9 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EEA22144.1 - 0.0039 16.6 0.0 1.1 8.6 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain PRP3 PF08572.10 EEA22144.1 - 0.0045 16.7 1.4 0.0045 16.7 1.4 2.0 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) Val_tRNA-synt_C PF10458.9 EEA22144.1 - 0.0085 16.4 5.9 0.0085 16.4 5.9 3.2 3 0 0 3 3 3 1 Valyl tRNA synthetase tRNA binding arm DUF4028 PF13220.6 EEA22144.1 - 0.086 12.6 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4028) Sugar_tr PF00083.24 EEA22147.1 - 1e-84 285.0 26.1 1.2e-84 284.8 26.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA22147.1 - 7.1e-15 54.8 36.7 9.3e-11 41.2 28.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA22147.1 - 0.00024 20.1 5.8 0.00024 20.1 5.8 2.3 2 0 0 2 2 2 2 MFS_1 like family SLATT_1 PF18181.1 EEA22148.1 - 0.098 12.6 0.6 0.25 11.3 0.6 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 ADH_zinc_N PF00107.26 EEA22149.1 - 1.5e-13 50.9 0.5 3.8e-13 49.5 0.2 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA22149.1 - 2.3e-05 24.3 0.0 6.9e-05 22.7 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EEA22149.1 - 0.0032 16.8 1.9 0.0032 16.8 0.8 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EEA22149.1 - 0.0061 17.6 0.0 0.02 15.9 0.0 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 EEA22149.1 - 0.036 14.0 0.4 0.036 14.0 0.4 1.6 2 0 0 2 2 2 0 NAD(P)H-binding NmrA PF05368.13 EEA22149.1 - 0.13 11.8 0.2 0.36 10.4 0.3 1.7 2 0 0 2 2 2 0 NmrA-like family DapB_N PF01113.20 EEA22149.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CDP-OH_P_transf PF01066.21 EEA22150.1 - 1.6e-15 57.6 0.2 1.6e-15 57.6 0.2 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Peptidase_M1_N PF17900.1 EEA22151.1 - 1.7e-06 28.3 0.0 0.089 13.0 0.0 2.5 1 1 0 2 2 2 2 Peptidase M1 N-terminal domain LSM PF01423.22 EEA22152.1 - 2.4e-22 78.4 0.5 2.6e-22 78.3 0.5 1.0 1 0 0 1 1 1 1 LSM domain LtrA PF06772.11 EEA22154.1 - 2.6e-17 63.1 15.3 2.6e-17 63.1 15.3 2.1 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) Ank_2 PF12796.7 EEA22155.1 - 5.6e-29 100.6 3.0 2.3e-10 40.9 0.0 9.7 4 2 8 12 12 11 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA22155.1 - 1e-13 51.2 1.4 8.4e-07 29.2 0.2 5.5 4 1 1 5 5 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA22155.1 - 6.4e-13 48.9 3.5 0.00035 21.1 0.0 8.4 9 1 2 11 11 10 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA22155.1 - 8.8e-13 47.2 0.2 0.65 10.8 0.0 9.7 11 0 0 11 11 8 2 Ankyrin repeat Ank PF00023.30 EEA22155.1 - 4.5e-09 36.4 5.6 0.26 11.8 0.0 9.1 10 0 0 10 10 8 2 Ankyrin repeat PNP_UDP_1 PF01048.20 EEA22155.1 - 1.2e-07 31.2 0.0 3.9e-07 29.6 0.0 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 EEA22155.1 - 1.8e-07 31.7 0.0 6e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EEA22155.1 - 2.8e-07 30.6 0.0 5.9e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EEA22155.1 - 0.00068 19.9 0.0 0.0028 17.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain Ploopntkinase3 PF18751.1 EEA22155.1 - 0.025 14.5 0.0 0.17 11.8 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 RNA_helicase PF00910.22 EEA22155.1 - 0.071 13.5 0.0 0.18 12.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase FtsK_SpoIIIE PF01580.18 EEA22155.1 - 0.072 12.4 3.8 2.8 7.2 0.0 3.3 4 0 0 4 4 4 0 FtsK/SpoIIIE family SseB_C PF14581.6 EEA22155.1 - 0.24 11.5 8.7 6.7 6.9 0.1 5.1 2 1 2 5 5 5 0 SseB protein C-terminal domain AAA_25 PF13481.6 EEA22155.1 - 0.35 10.4 6.1 3.5 7.2 0.0 4.2 2 1 1 4 4 4 0 AAA domain PepSY_like PF11396.8 EEA22155.1 - 1.2 9.7 5.1 56 4.4 0.2 5.0 4 1 1 6 6 5 0 Putative beta-lactamase-inhibitor-like, PepSY-like DUF3868 PF12984.7 EEA22155.1 - 3.7 7.4 13.1 14 5.5 0.0 6.1 5 2 0 6 6 6 0 Domain of unknown function, B. Theta Gene description (DUF3868) NAGLU PF05089.12 EEA22157.1 - 1.7e-130 434.9 7.5 1.7e-130 434.9 7.5 1.5 2 0 0 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 EEA22157.1 - 2.2e-66 224.1 1.6 3.7e-66 223.4 1.6 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 EEA22157.1 - 2.9e-19 68.6 0.0 7.2e-19 67.4 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain MFS_1 PF07690.16 EEA22158.1 - 1.5e-11 43.8 41.4 1.5e-11 43.8 41.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Ank_2 PF12796.7 EEA22158.1 - 1.3e-07 32.1 0.0 2.7e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA22158.1 - 0.0004 20.7 0.0 0.36 11.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EEA22158.1 - 0.00098 19.4 0.0 0.85 10.4 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EEA22158.1 - 0.0082 16.7 0.0 0.03 14.9 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) CBM_4_9 PF02018.17 EEA22159.1 - 7.3e-12 45.7 0.5 1.7e-11 44.6 0.5 1.6 1 0 0 1 1 1 1 Carbohydrate binding domain RTC_insert PF05189.13 EEA22162.1 - 2.8e-30 104.9 0.0 5.8e-30 103.9 0.0 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 EEA22162.1 - 7.7e-28 97.2 0.0 9.8e-28 96.9 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase 3-HAO PF06052.12 EEA22163.1 - 1.2e-52 177.5 0.0 1.4e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EEA22163.1 - 0.00025 20.7 0.0 0.00047 19.8 0.0 1.6 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EEA22163.1 - 0.00087 18.9 0.1 0.0018 17.9 0.1 1.5 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EEA22163.1 - 0.024 14.5 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain Zn-ribbon_8 PF09723.10 EEA22163.1 - 0.08 13.1 0.4 0.08 13.1 0.4 1.8 2 0 0 2 2 2 0 Zinc ribbon domain CAP_GLY PF01302.25 EEA22164.1 - 9.6e-16 57.6 1.5 1.8e-15 56.7 0.9 1.8 2 0 0 2 2 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EEA22164.1 - 4.1e-09 36.1 10.7 5e-05 23.1 0.9 2.7 2 0 0 2 2 2 2 CLIP1 zinc knuckle TPR_MLP1_2 PF07926.12 EEA22164.1 - 0.0049 16.9 16.8 0.0049 16.9 16.8 3.6 2 1 1 3 3 3 1 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.12 EEA22164.1 - 0.007 16.8 10.9 0.02 15.3 1.5 3.4 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein Spectrin PF00435.21 EEA22164.1 - 0.031 14.7 25.2 0.025 15.1 6.9 3.4 1 1 1 3 3 3 0 Spectrin repeat Fe-S_assembly PF04384.13 EEA22164.1 - 0.043 14.4 0.5 18 6.0 0.1 2.8 2 0 0 2 2 2 0 Iron-sulphur cluster assembly FAM76 PF16046.5 EEA22164.1 - 0.043 13.2 15.0 0.041 13.3 5.5 3.2 2 1 1 3 3 3 0 FAM76 protein DUF1664 PF07889.12 EEA22164.1 - 0.066 13.3 14.0 0.63 10.1 2.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 EEA22164.1 - 0.13 10.9 21.9 0.018 13.7 9.7 2.6 1 1 2 3 3 3 0 AAA domain DUF4795 PF16043.5 EEA22164.1 - 0.14 11.7 13.2 0.071 12.7 9.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Ribosomal_S15 PF00312.22 EEA22164.1 - 0.18 12.1 1.1 2.2 8.6 0.1 2.9 2 1 1 3 3 3 0 Ribosomal protein S15 ATG16 PF08614.11 EEA22164.1 - 0.37 11.0 37.0 11 6.1 16.9 3.5 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) SlyX PF04102.12 EEA22164.1 - 0.51 11.0 27.6 2.8 8.6 8.1 4.0 4 1 0 4 4 3 0 SlyX DUF812 PF05667.11 EEA22164.1 - 0.65 8.8 27.4 0.33 9.8 16.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF812) Fez1 PF06818.15 EEA22164.1 - 0.68 10.4 31.0 0.27 11.7 16.9 3.3 1 1 2 3 3 3 0 Fez1 DUF5320 PF17253.2 EEA22164.1 - 0.8 10.8 0.1 0.8 10.8 0.1 3.4 4 1 0 4 4 2 0 Family of unknown function (DUF5320) BLOC1_2 PF10046.9 EEA22164.1 - 0.81 10.0 20.6 1.5 9.2 3.2 4.1 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.16 EEA22164.1 - 0.95 10.0 24.3 3 8.4 0.3 4.8 2 1 3 5 5 4 0 Protein of unknown function DUF16 Baculo_PEP_C PF04513.12 EEA22164.1 - 1.2 9.2 7.5 3.3 7.8 3.1 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 EEA22164.1 - 1.2 7.9 33.9 0.77 8.6 11.6 3.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF3584 PF12128.8 EEA22164.1 - 1.8 6.0 25.6 3.3 5.1 25.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) C1_2 PF03107.16 EEA22164.1 - 1.8 8.9 3.3 28 5.2 0.2 2.4 2 0 0 2 2 2 0 C1 domain EzrA PF06160.12 EEA22164.1 - 2.1 6.4 21.2 0.87 7.7 7.6 2.7 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA Peptidase_S46 PF10459.9 EEA22164.1 - 2.5 6.6 11.7 3.6 6.1 11.7 1.1 1 0 0 1 1 1 0 Peptidase S46 SKA1 PF07160.12 EEA22164.1 - 2.8 7.7 11.0 2.9 7.7 3.6 2.6 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 TolA_bind_tri PF16331.5 EEA22164.1 - 3.9 7.6 34.1 2.3 8.4 3.7 4.5 2 1 2 4 4 3 0 TolA binding protein trimerisation TMF_DNA_bd PF12329.8 EEA22164.1 - 7.6 6.6 34.1 0.29 11.1 2.4 5.2 4 2 1 5 5 5 0 TATA element modulatory factor 1 DNA binding DUF4407 PF14362.6 EEA22164.1 - 7.8 5.8 25.8 8.7e+03 -4.2 25.8 2.8 1 1 0 1 1 0 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 EEA22164.1 - 8.7 6.1 22.4 0.68 9.7 4.7 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Phage_GP20 PF06810.11 EEA22164.1 - 10 5.9 23.9 6.4 6.6 7.0 3.6 2 1 1 3 3 3 0 Phage minor structural protein GP20 Pkinase PF00069.25 EEA22165.1 - 5.8e-38 130.8 0.0 3.3e-21 75.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22165.1 - 3.4e-14 52.7 0.0 1.6e-06 27.7 0.0 2.9 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA22165.1 - 0.0011 18.3 0.0 0.43 9.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EEA22165.1 - 0.021 14.8 0.1 0.034 14.1 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family SpoIIE PF07228.12 EEA22166.1 - 5.9e-13 49.2 0.1 1.5e-12 47.9 0.1 1.6 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EEA22166.1 - 4.1e-11 42.9 0.6 7e-11 42.2 0.6 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 EEA22166.1 - 5.4e-08 32.8 0.1 0.0079 15.8 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C DUF3446 PF11928.8 EEA22166.1 - 9.2 6.7 17.8 0.27 11.5 1.8 2.9 2 1 0 2 2 2 0 Early growth response N-terminal domain Abhydrolase_1 PF00561.20 EEA22167.1 - 0.036 13.7 1.8 0.071 12.7 1.6 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF5639 PF18690.1 EEA22167.1 - 0.052 13.7 0.0 0.61 10.3 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5639) Peptidase_S9 PF00326.21 EEA22167.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.5 1 1 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EEA22167.1 - 0.21 10.9 0.0 0.31 10.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF1100 PF06500.11 EEA22167.1 - 0.26 10.1 0.0 0.32 9.7 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) zf-C2H2 PF00096.26 EEA22168.1 - 2.8e-05 24.3 18.8 0.14 12.6 0.2 5.1 5 0 0 5 5 5 4 Zinc finger, C2H2 type YL1 PF05764.13 EEA22168.1 - 0.011 15.9 2.4 0.17 12.0 3.0 2.1 2 0 0 2 2 2 0 YL1 nuclear protein zf-C2H2_4 PF13894.6 EEA22168.1 - 0.088 13.7 18.7 1.1 10.3 0.3 5.0 4 1 0 4 4 4 0 C2H2-type zinc finger FOXP-CC PF16159.5 EEA22168.1 - 0.19 12.4 7.8 1.5 9.5 1.0 3.6 3 0 0 3 3 3 0 FOXP coiled-coil domain zf-met PF12874.7 EEA22168.1 - 0.29 11.6 1.9 6.6 7.3 0.6 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA22168.1 - 6.2 7.2 6.6 5 7.5 0.6 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF3431 PF11913.8 EEA22169.1 - 1.1e-91 306.4 0.1 1.7e-91 305.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) zf-rbx1 PF12678.7 EEA22170.1 - 1.6e-10 41.1 3.7 2.8e-10 40.3 3.7 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EEA22170.1 - 4.6e-08 33.3 7.8 1.5e-07 31.7 7.8 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EEA22170.1 - 3.1e-07 30.2 2.3 5.4e-07 29.4 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA22170.1 - 1.2e-05 25.2 1.5 2.3e-05 24.3 1.5 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EEA22170.1 - 2.4e-05 24.1 6.5 0.00013 21.8 2.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA22170.1 - 5.6e-05 23.0 2.5 0.0002 21.2 2.7 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EEA22170.1 - 8e-05 22.4 3.4 0.0002 21.2 3.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EEA22170.1 - 0.00016 21.2 1.0 0.00034 20.2 1.0 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EEA22170.1 - 0.0018 18.3 4.5 0.0078 16.2 4.5 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EEA22170.1 - 0.0058 16.5 5.5 0.016 15.0 5.6 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EEA22170.1 - 0.052 13.3 2.3 0.46 10.3 0.3 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 EEA22170.1 - 0.08 13.1 0.9 0.16 12.2 0.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-3CxxC_2 PF17180.4 EEA22170.1 - 0.33 11.7 1.1 21 5.9 0.3 2.5 1 1 1 2 2 2 0 Zinc-binding domain FANCL_C PF11793.8 EEA22170.1 - 3.1 8.0 4.1 17 5.7 4.1 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain MFS_1 PF07690.16 EEA22171.1 - 2.9e-19 69.2 35.2 2.7e-10 39.7 3.8 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA22171.1 - 5.5e-05 22.2 0.2 0.18 10.6 1.3 3.0 2 2 0 2 2 2 2 MFS_1 like family DUF2206 PF09971.9 EEA22171.1 - 0.059 12.1 0.1 0.099 11.4 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) ATP_transf PF09830.9 EEA22172.1 - 4.1e-24 84.5 0.1 1.9e-23 82.4 0.0 2.2 3 0 0 3 3 3 1 ATP adenylyltransferase Trypan_PARP PF05887.11 EEA22173.1 - 0.035 14.1 14.6 0.065 13.2 14.6 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RPN7 PF10602.9 EEA22174.1 - 3.8e-46 157.0 0.0 7.2e-46 156.1 0.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EEA22174.1 - 1.2e-13 51.5 0.1 2.9e-12 47.0 0.0 2.8 2 1 1 3 3 3 1 PCI domain DSBA PF01323.20 EEA22175.1 - 5.6e-23 81.7 0.0 6.3e-23 81.6 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain DUF2336 PF10098.9 EEA22175.1 - 0.11 12.0 0.1 0.17 11.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) DUF5311 PF17238.2 EEA22175.1 - 0.21 11.5 0.0 0.28 11.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5311) adh_short PF00106.25 EEA22176.1 - 7.5e-26 90.8 0.4 4.6e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22176.1 - 5.1e-20 72.0 0.2 2.9e-15 56.5 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22176.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 KR domain DUF1776 PF08643.10 EEA22176.1 - 0.2 11.0 0.0 0.5 9.7 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) BTB PF00651.31 EEA22177.1 - 0.013 15.7 1.4 0.83 9.9 0.0 3.0 3 0 0 3 3 3 0 BTB/POZ domain Fungal_trans PF04082.18 EEA22178.1 - 3.9e-13 49.0 0.1 6.1e-13 48.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22178.1 - 8.4e-09 35.4 10.9 1.5e-08 34.6 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DarA_C PF18789.1 EEA22178.1 - 0.19 12.1 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 Defence against restriction A C-terminal adh_short PF00106.25 EEA22179.1 - 2.2e-26 92.5 0.0 2.8e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22179.1 - 6.2e-22 78.3 0.0 7.2e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22179.1 - 1.2e-06 28.6 0.0 1.5e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA22179.1 - 0.0014 18.5 0.0 0.0021 18.0 0.0 1.3 1 1 0 1 1 1 1 NAD(P)H-binding DUF1768 PF08719.11 EEA22180.1 - 3.9e-52 176.7 0.0 4.5e-52 176.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Aldo_ket_red PF00248.21 EEA22181.1 - 2.8e-38 131.8 0.0 8.8e-36 123.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Cas9_Topo PF17894.1 EEA22181.1 - 0.12 12.4 0.0 2.2 8.4 0.0 2.4 2 0 0 2 2 2 0 Topo homolgy domain in CRISPR-associated endonuclease Cas9 HSCB_C PF07743.13 EEA22182.1 - 9.9e-19 67.6 2.8 1.6e-18 67.0 1.2 1.9 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EEA22182.1 - 8.9e-07 28.9 0.0 1.8e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 EEA22183.1 - 1.8e-36 123.5 21.1 1.1e-08 35.5 2.1 7.8 7 1 0 7 7 7 5 WD domain, G-beta repeat PRP4 PF08799.11 EEA22183.1 - 1.1e-14 53.7 5.3 1.9e-14 52.9 5.3 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EEA22183.1 - 2.7e-13 50.0 0.3 0.012 15.9 0.0 5.7 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA22183.1 - 0.0017 17.4 0.0 11 4.8 0.0 4.3 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EEA22183.1 - 0.0057 16.6 0.0 0.71 9.7 0.0 3.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EEA22183.1 - 0.017 14.4 0.0 0.21 10.9 0.0 2.7 3 1 1 4 4 4 0 WD40-like domain Nup160 PF11715.8 EEA22183.1 - 0.75 8.4 3.6 11 4.5 0.0 2.9 2 2 1 3 3 3 0 Nucleoporin Nup120/160 PWWP PF00855.17 EEA22184.1 - 1.2e-16 60.8 8.4 1.9e-16 60.2 3.1 3.5 2 2 0 2 2 2 1 PWWP domain ComA PF02679.15 EEA22185.1 - 7.9e-89 297.3 0.0 9.4e-89 297.0 0.0 1.0 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) DUF2542 PF10808.8 EEA22185.1 - 0.02 15.4 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2542) p450 PF00067.22 EEA22186.1 - 1.7e-61 208.4 0.0 2.4e-61 207.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SHD1 PF03983.12 EEA22187.1 - 3.9e-35 119.5 0.0 6.9e-35 118.7 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.28 EEA22187.1 - 1.7e-34 117.1 6.2 5.6e-13 48.3 0.1 4.4 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EEA22187.1 - 5.4e-30 103.0 9.6 5.3e-12 45.4 0.5 3.9 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EEA22187.1 - 3.1e-22 78.0 0.0 2.1e-07 30.5 0.0 4.5 4 0 0 4 4 4 4 Variant SH3 domain DUF1720 PF08226.11 EEA22187.1 - 2.2e-07 31.2 148.6 0.00052 20.4 38.9 6.4 1 1 4 5 5 5 3 Domain of unknown function (DUF1720) SH3_10 PF17902.1 EEA22187.1 - 0.00019 21.4 0.1 0.064 13.3 0.0 3.3 3 0 0 3 3 3 1 SH3 domain SAM_4 PF18017.1 EEA22187.1 - 0.0025 17.8 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EEA22187.1 - 0.032 14.7 0.0 0.06 13.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SH3_3 PF08239.11 EEA22187.1 - 0.2 12.0 3.9 0.28 11.5 0.8 2.6 3 0 0 3 3 3 0 Bacterial SH3 domain Pkinase PF00069.25 EEA22188.1 - 4.4e-21 75.4 0.1 7.9e-21 74.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22188.1 - 1.9e-14 53.6 0.0 3.9e-14 52.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EEA22188.1 - 0.031 13.2 0.0 0.053 12.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EEA22188.1 - 0.043 13.7 0.0 0.22 11.4 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family AA_permease PF00324.21 EEA22189.1 - 4.1e-27 94.9 27.5 2.7e-26 92.2 27.5 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA22189.1 - 1.1e-17 64.0 28.4 1.4e-17 63.7 28.4 1.1 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.13 EEA22189.1 - 0.22 10.3 12.2 0.46 9.3 12.2 1.5 1 0 0 1 1 1 0 Spore germination protein DDE_1 PF03184.19 EEA22190.1 - 3.9e-23 82.0 0.0 7.9e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22190.1 - 9e-09 35.2 0.3 3.1e-08 33.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA22190.1 - 0.026 14.6 0.1 0.53 10.5 0.0 2.7 3 0 0 3 3 3 0 Transcription factor Pcc1 Amidase PF01425.21 EEA22190.1 - 0.055 12.4 1.6 0.083 11.8 1.6 1.2 1 0 0 1 1 1 0 Amidase CorA PF01544.18 EEA22191.1 - 0.0093 15.3 5.2 0.025 13.9 5.2 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein PRKCSH PF07915.13 EEA22192.1 - 4.1e-21 75.8 0.8 1.4e-20 74.0 0.8 2.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein bPH_5 PF10882.8 EEA22192.1 - 0.016 15.3 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial PH domain PRKCSH_1 PF13015.6 EEA22192.1 - 0.042 13.5 0.1 0.095 12.4 0.1 1.7 1 1 0 1 1 1 0 Glucosidase II beta subunit-like protein P_proprotein PF01483.20 EEA22192.1 - 0.33 11.0 1.1 5 7.2 0.0 2.5 3 0 0 3 3 3 0 Proprotein convertase P-domain EthD PF07110.11 EEA22193.1 - 0.065 14.4 0.0 0.15 13.3 0.0 1.5 1 1 0 1 1 1 0 EthD domain PapD-like PF14874.6 EEA22194.1 - 0.087 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Flagellar-associated PapD-like Pirin PF02678.16 EEA22195.1 - 1.2e-30 105.6 0.1 2.4e-30 104.7 0.1 1.5 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EEA22195.1 - 1.8e-23 82.8 0.0 9.3e-23 80.6 0.0 2.0 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EEA22195.1 - 4.9e-06 26.2 1.4 9.5e-05 22.0 1.1 2.3 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 EEA22195.1 - 0.056 13.1 0.1 0.71 9.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF861) PMT PF02366.18 EEA22196.1 - 2.8e-84 282.6 17.6 5.6e-84 281.5 17.6 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EEA22196.1 - 9.9e-69 230.9 2.8 9.9e-69 230.9 2.8 3.1 3 1 0 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EEA22196.1 - 3.2e-18 66.2 0.7 5.9e-18 65.4 0.7 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 EEA22196.1 - 1.5 9.0 24.8 0.028 14.6 3.3 4.0 4 1 1 5 5 5 0 Dolichyl-phosphate-mannose-protein mannosyltransferase HTH_26 PF13443.6 EEA22197.1 - 0.037 14.5 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain MFS_1 PF07690.16 EEA22198.1 - 9.8e-34 116.8 28.9 9.8e-34 116.8 28.9 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily WD40 PF00400.32 EEA22199.1 - 0.00029 21.6 7.3 5.6 8.0 0.1 5.1 6 1 0 6 6 6 3 WD domain, G-beta repeat Kri1 PF05178.12 EEA22199.1 - 0.064 13.8 0.3 1.8 9.2 0.7 2.4 2 1 0 2 2 2 0 KRI1-like family Dynein_IC2 PF11540.8 EEA22199.1 - 0.076 13.0 1.1 0.2 11.7 1.1 1.7 1 0 0 1 1 1 0 Cytoplasmic dynein 1 intermediate chain 2 ATP-synt_E PF05680.12 EEA22200.1 - 1.3e-20 73.6 0.3 1.3e-20 73.5 0.3 1.1 1 0 0 1 1 1 1 ATP synthase E chain Adhesin_P1_N PF18652.1 EEA22200.1 - 0.12 12.4 2.5 0.23 11.5 2.5 1.5 1 0 0 1 1 1 0 Adhesin P1 N-terminal domain CSN8_PSD8_EIF3K PF10075.9 EEA22201.1 - 4.7e-27 94.7 0.1 6.6e-27 94.3 0.1 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family STT3 PF02516.14 EEA22202.1 - 7.4e-147 490.2 36.6 4.1e-142 474.6 34.1 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF3453 PF11935.8 EEA22203.1 - 2.7e-71 239.8 0.4 6.8e-71 238.5 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) Adaptin_N PF01602.20 EEA22203.1 - 0.18 10.3 0.4 11 4.4 0.0 2.4 2 1 0 2 2 2 0 Adaptin N terminal region Coiled-coil_56 PF09813.9 EEA22204.1 - 1.1e-06 28.6 0.0 1.1e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 Sds3 PF08598.11 EEA22205.1 - 1.7e-14 54.3 5.0 1.7e-14 54.3 5.0 2.3 2 2 0 2 2 2 1 Sds3-like DUF1487 PF07368.11 EEA22205.1 - 0.16 11.4 0.2 0.42 10.0 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) RRM_1 PF00076.22 EEA22206.1 - 2.9e-11 43.0 0.0 4.5e-07 29.6 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CHASE4 PF05228.13 EEA22206.1 - 0.032 14.5 0.0 0.062 13.5 0.0 1.5 1 0 0 1 1 1 0 CHASE4 domain Baculo_PEP_C PF04513.12 EEA22210.1 - 7.4 6.6 21.9 1.5 8.9 0.8 4.4 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Methyltransf_16 PF10294.9 EEA22212.1 - 0.01 15.6 0.0 0.44 10.3 0.0 2.3 2 0 0 2 2 2 0 Lysine methyltransferase Cys_Met_Meta_PP PF01053.20 EEA22213.1 - 3.3e-140 467.0 0.0 3.8e-140 466.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EEA22213.1 - 1.1e-08 34.7 0.1 1.7e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EEA22213.1 - 1.5e-06 27.8 0.3 3.1e-06 26.7 0.3 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EEA22213.1 - 5.9e-06 25.5 0.1 1.2e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA22213.1 - 0.001 18.4 0.3 0.0027 17.0 0.3 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 EEA22213.1 - 0.068 12.0 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycine cleavage system P-protein RNA_pol_Rbc25 PF08292.12 EEA22214.1 - 2.5e-35 121.5 0.3 5.6e-35 120.4 0.3 1.6 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EEA22214.1 - 1.1e-14 54.6 0.0 1.6e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 NUFIP1 PF10453.9 EEA22215.1 - 2.4e-13 49.7 7.9 2.4e-13 49.7 7.9 2.4 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.24 EEA22215.1 - 1.2e-06 28.2 5.9 2.1e-06 27.5 5.9 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EEA22215.1 - 2.8e-05 24.0 6.8 2.8e-05 24.0 6.8 1.8 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 EEA22215.1 - 8.6e-05 22.2 6.3 8.6e-05 22.2 6.3 1.6 2 0 0 2 2 2 1 CCCH-type zinc finger Torus PF16131.5 EEA22215.1 - 0.043 14.5 0.0 0.043 14.5 0.0 2.5 2 0 0 2 2 2 0 Torus domain zf-CCCH_2 PF14608.6 EEA22215.1 - 0.55 10.8 4.3 0.97 10.0 4.3 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF2514 PF10721.9 EEA22215.1 - 1.7 8.6 20.0 4.1 7.4 20.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) GPI-anchored PF10342.9 EEA22216.1 - 3.2e-21 75.9 0.2 3.2e-21 75.9 0.2 3.0 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SOG2 PF10428.9 EEA22216.1 - 0.048 12.9 18.7 0.057 12.6 18.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 EEA22216.1 - 0.18 11.7 6.6 0.18 11.7 6.6 1.1 1 0 0 1 1 1 0 SPX domain RIFIN PF02009.16 EEA22216.1 - 1.7 8.5 3.3 2 8.2 3.3 1.1 1 0 0 1 1 1 0 Rifin Apt1 PF10351.9 EEA22216.1 - 2.4 6.9 14.6 3 6.6 14.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 EEA22216.1 - 2.6 7.4 4.0 2.9 7.2 4.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ABC_tran PF00005.27 EEA22217.1 - 3.2e-51 173.4 0.1 1.6e-27 96.7 0.1 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA22217.1 - 3.4e-26 92.5 36.1 1.4e-23 84.0 15.5 2.8 2 1 1 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA22217.1 - 6.9e-09 35.5 4.2 0.018 14.5 0.1 4.0 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA22217.1 - 3.3e-07 30.4 3.7 0.049 13.4 0.0 4.1 4 1 1 5 5 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA22217.1 - 3.5e-06 26.7 0.6 0.041 13.6 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA22217.1 - 1.2e-05 25.8 0.1 0.034 14.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA22217.1 - 1.2e-05 25.2 0.2 0.0061 16.5 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 EEA22217.1 - 1.3e-05 25.8 0.8 0.053 14.0 0.1 2.4 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EEA22217.1 - 1.6e-05 24.1 0.1 0.0068 15.5 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EEA22217.1 - 3.9e-05 23.7 0.5 0.34 11.0 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase NB-ARC PF00931.22 EEA22217.1 - 5.2e-05 22.5 0.7 0.0092 15.2 0.0 2.7 2 1 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 EEA22217.1 - 9.3e-05 22.7 0.9 0.2 11.9 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA PF00004.29 EEA22217.1 - 0.00047 20.6 0.1 0.23 11.9 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EEA22217.1 - 0.0029 18.0 0.4 0.46 10.9 0.0 3.2 3 0 0 3 3 2 1 RNA helicase AAA_7 PF12775.7 EEA22217.1 - 0.0035 16.9 0.1 0.74 9.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_15 PF13175.6 EEA22217.1 - 0.0041 16.9 0.1 0.88 9.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.6 EEA22217.1 - 0.0062 16.9 0.2 2.2 8.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EEA22217.1 - 0.0081 15.8 0.0 0.46 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EEA22217.1 - 0.0087 16.1 0.2 0.87 9.6 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.6 EEA22217.1 - 0.014 15.2 0.2 2 8.1 0.0 3.0 3 1 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 EEA22217.1 - 0.014 14.6 0.0 0.94 8.7 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin ATPase_2 PF01637.18 EEA22217.1 - 0.015 15.2 0.1 0.27 11.1 0.0 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EEA22217.1 - 0.024 15.2 0.0 4.3 7.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EEA22217.1 - 0.028 13.6 0.1 5.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Rad17 PF03215.15 EEA22217.1 - 0.034 14.1 0.0 0.095 12.6 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain NTPase_1 PF03266.15 EEA22217.1 - 0.039 13.9 0.9 5.6 6.8 0.1 2.6 2 0 0 2 2 2 0 NTPase Adeno_IVa2 PF02456.15 EEA22217.1 - 0.042 12.7 0.5 0.17 10.7 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_14 PF13173.6 EEA22217.1 - 0.045 13.8 0.1 0.21 11.6 0.0 2.2 3 0 0 3 3 1 0 AAA domain Roc PF08477.13 EEA22217.1 - 0.051 13.8 0.2 36 4.6 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EEA22217.1 - 0.057 13.6 0.6 1.4 9.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EEA22217.1 - 0.061 12.9 1.3 0.88 9.1 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 EEA22217.1 - 0.079 12.7 4.3 19 4.9 0.0 3.6 4 0 0 4 4 3 0 IstB-like ATP binding protein MeaB PF03308.16 EEA22217.1 - 0.082 11.9 0.2 2.6 6.9 0.1 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EEA22217.1 - 0.1 12.3 1.2 6.2 6.5 0.1 2.9 2 1 1 3 3 3 0 AAA domain Viral_helicase1 PF01443.18 EEA22217.1 - 0.11 12.2 0.1 1.7 8.3 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EEA22217.1 - 0.11 12.2 0.0 0.65 9.7 0.0 2.1 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EEA22217.1 - 0.14 12.1 0.7 2.5 8.0 0.0 2.5 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.9 EEA22217.1 - 0.17 11.6 0.3 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.17 EEA22217.1 - 0.18 11.9 2.1 0.63 10.1 0.4 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain ABC_ATPase PF09818.9 EEA22217.1 - 0.3 9.8 1.6 1.2 7.8 0.1 2.5 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Condensation PF00668.20 EEA22218.1 - 0 1363.5 1.0 9.8e-56 189.3 0.0 12.7 11 3 0 11 11 11 10 Condensation domain AMP-binding PF00501.28 EEA22218.1 - 0 1263.6 0.0 1.4e-77 261.1 0.0 5.2 5 0 0 5 5 5 5 AMP-binding enzyme PP-binding PF00550.25 EEA22218.1 - 1.2e-85 281.8 9.2 1.4e-12 47.8 0.0 7.9 7 0 0 7 7 7 7 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA22218.1 - 1.4e-09 38.8 0.0 0.76 10.8 0.0 5.7 5 0 0 5 5 5 3 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EEA22218.1 - 0.0004 19.1 0.2 1.1 7.8 0.0 3.1 3 0 0 3 3 3 2 Transferase family DUF600 PF04634.12 EEA22218.1 - 0.042 13.9 0.6 7.9 6.5 0.1 4.3 4 0 0 4 4 4 0 Protein of unknown function, DUF600 DUF5122 PF17164.4 EEA22218.1 - 4.9 7.5 5.2 35 4.8 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller Pyr_redox_2 PF07992.14 EEA22219.1 - 9.3e-08 31.6 0.0 1.4e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA22219.1 - 0.00014 21.9 0.0 0.0011 18.9 0.0 2.4 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EEA22219.1 - 0.00026 20.3 0.0 0.00066 18.9 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EEA22219.1 - 0.0051 16.1 0.0 0.5 9.6 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FOXP-CC PF16159.5 EEA22220.1 - 0.004 17.8 1.2 0.004 17.8 1.2 3.6 2 1 1 3 3 3 1 FOXP coiled-coil domain zf-C2H2 PF00096.26 EEA22220.1 - 0.0053 17.1 22.8 0.56 10.8 1.2 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type Acetyltransf_1 PF00583.25 EEA22221.1 - 1.2e-10 41.7 0.1 1.6e-10 41.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA22221.1 - 3.5e-09 37.0 0.3 5.6e-09 36.3 0.3 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA22221.1 - 9e-07 28.9 0.1 1.3e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA22221.1 - 0.041 14.0 0.2 0.077 13.1 0.2 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA22221.1 - 0.067 13.3 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FOXP-CC PF16159.5 EEA22223.1 - 3 8.5 12.5 0.69 10.6 0.4 3.4 3 0 0 3 3 3 0 FOXP coiled-coil domain MFS_1 PF07690.16 EEA22224.1 - 7.9e-09 34.9 29.8 7.9e-09 34.9 29.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA22224.1 - 2.8e-06 26.5 11.7 3.6e-06 26.1 11.7 1.1 1 0 0 1 1 1 1 MFS_1 like family PHO4 PF01384.20 EEA22224.1 - 0.017 14.2 14.1 0.025 13.6 14.1 1.2 1 0 0 1 1 1 0 Phosphate transporter family Ank_2 PF12796.7 EEA22225.1 - 1.9e-57 191.8 8.4 3e-15 56.6 0.0 5.0 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA22225.1 - 1.4e-34 118.0 3.3 3.2e-08 34.0 0.0 5.6 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EEA22225.1 - 1.6e-29 101.0 14.4 0.0001 22.6 0.0 9.5 9 0 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 EEA22225.1 - 4.2e-28 94.3 3.4 0.00052 20.3 0.0 9.5 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EEA22225.1 - 3.3e-27 94.2 7.2 5.3e-05 23.4 0.0 7.6 2 2 6 8 8 8 6 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 EEA22225.1 - 5e-12 45.6 0.4 2.3e-05 23.8 0.0 3.2 3 0 0 3 3 3 2 Phosphorylase superfamily NACHT PF05729.12 EEA22225.1 - 0.00085 19.3 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Sigma_M_inh PF17453.2 EEA22225.1 - 0.007 16.8 0.0 1.6 9.2 0.0 2.9 3 0 0 3 3 3 1 Sigma-M inhibitor AAA_22 PF13401.6 EEA22225.1 - 0.032 14.5 0.0 0.077 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF1351 PF07083.11 EEA22225.1 - 0.27 11.0 3.5 0.21 11.3 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) Carb_kinase PF01256.17 EEA22226.1 - 1.7e-44 152.1 0.2 1.5e-43 149.0 0.2 1.9 1 1 0 1 1 1 1 Carbohydrate kinase SPT2 PF08243.11 EEA22227.1 - 1.9e-08 34.8 16.3 1.9e-08 34.8 16.3 2.0 2 1 0 2 2 2 1 SPT2 chromatin protein Ribosomal_60s PF00428.19 EEA22228.1 - 1.7e-27 95.8 12.5 2e-27 95.6 12.5 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein EF-hand_14 PF17959.1 EEA22228.1 - 0.14 12.5 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain Cytomega_UL84 PF06284.11 EEA22228.1 - 0.15 10.5 1.7 0.17 10.3 1.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3824 PF12868.7 EEA22228.1 - 2.4 8.8 5.4 3.3 8.4 5.4 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Ribosomal_S19 PF00203.21 EEA22229.1 - 7.7e-34 115.4 0.3 1.1e-33 114.9 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 SET PF00856.28 EEA22230.1 - 7.1e-15 55.8 1.7 8.5e-15 55.5 0.0 2.0 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 EEA22230.1 - 2e-07 31.0 12.5 2e-07 31.0 12.5 2.5 2 1 1 3 3 3 1 MYND finger Nop14 PF04147.12 EEA22232.1 - 0.16 10.2 10.6 0.2 9.8 10.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EEA22232.1 - 0.49 8.6 10.1 0.21 9.8 6.6 2.0 2 0 0 2 2 2 0 CDC45-like protein CPSase_L_D2 PF02786.17 EEA22234.1 - 1.1e-107 358.4 0.0 1e-84 283.3 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EEA22234.1 - 5.2e-41 139.8 0.0 1.3e-40 138.5 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Dala_Dala_lig_C PF07478.13 EEA22234.1 - 5e-18 65.4 0.3 9.6e-08 31.8 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EEA22234.1 - 6.2e-18 65.0 0.0 8e-08 32.0 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EEA22234.1 - 3.2e-10 39.8 0.0 0.0012 18.6 0.0 3.1 3 1 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 EEA22234.1 - 2.5e-06 27.1 0.0 0.007 15.8 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 EEA22234.1 - 8.5e-05 22.4 0.0 0.14 11.9 0.0 2.5 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 EEA22234.1 - 0.00095 18.8 0.0 1.3 8.6 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 EEA22234.1 - 0.072 12.5 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Epimerase PF01370.21 EEA22234.1 - 0.085 12.3 0.0 1.1 8.6 0.0 2.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Dehydratase_SU PF02287.15 EEA22235.1 - 0.00041 20.4 2.2 0.0041 17.2 0.5 2.7 2 0 0 2 2 2 1 Dehydratase small subunit USP8_interact PF08941.10 EEA22235.1 - 2.6 7.8 9.8 0.059 13.2 1.2 2.5 3 0 0 3 3 3 0 USP8 interacting DUF4187 PF13821.6 EEA22237.1 - 7.9e-22 76.8 1.4 2e-21 75.5 1.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EEA22237.1 - 3.4e-06 26.8 0.5 0.0039 17.1 0.1 2.5 2 0 0 2 2 2 2 G-patch domain DAZAP2 PF11029.8 EEA22237.1 - 0.061 14.2 1.2 0.12 13.4 1.2 1.4 1 0 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) COesterase PF00135.28 EEA22238.1 - 3e-85 287.0 0.0 3.9e-85 286.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA22238.1 - 1.9e-07 31.2 0.1 9.2e-07 28.9 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA22238.1 - 0.013 15.0 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Nop14 PF04147.12 EEA22239.1 - 5.8e-293 974.4 31.9 7.2e-293 974.1 31.9 1.1 1 0 0 1 1 1 1 Nop14-like family TAN PF11640.8 EEA22240.1 - 0.014 15.5 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair Osteopontin PF00865.18 EEA22240.1 - 0.52 9.8 7.6 0.98 8.9 7.6 1.4 1 0 0 1 1 1 0 Osteopontin NOA36 PF06524.12 EEA22240.1 - 8.8 5.6 5.8 15 4.8 5.8 1.3 1 0 0 1 1 1 0 NOA36 protein ORC3_N PF07034.11 EEA22241.1 - 7.8e-36 123.8 0.0 2.7e-33 115.5 0.0 2.6 2 1 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EEA22241.1 - 1.7e-25 89.7 0.1 9.7e-15 54.9 0.0 2.7 1 1 1 2 2 2 2 Origin recognition complex winged helix C-terminal SseC PF04888.12 EEA22241.1 - 0.16 11.5 0.6 13 5.3 0.0 2.7 3 0 0 3 3 3 0 Secretion system effector C (SseC) like family PDGF_N PF04692.13 EEA22241.1 - 0.57 11.0 3.7 0.52 11.1 0.7 2.5 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region PPR_2 PF13041.6 EEA22242.1 - 1.1e-05 25.5 0.0 3.3 8.0 0.0 5.2 5 0 0 5 5 5 2 PPR repeat family PPR PF01535.20 EEA22242.1 - 0.0095 16.1 0.5 40 4.8 0.0 4.4 4 0 0 4 4 4 1 PPR repeat PPR_3 PF13812.6 EEA22242.1 - 0.01 15.9 0.0 18 5.5 0.0 3.4 3 0 0 3 3 3 2 Pentatricopeptide repeat domain HypF_C PF17788.1 EEA22242.1 - 0.13 13.0 0.1 32 5.3 0.0 2.5 2 0 0 2 2 2 0 HypF Kae1-like domain Sec66 PF09802.9 EEA22243.1 - 9.4e-81 269.7 1.3 1.1e-80 269.4 1.3 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3848 PF12959.7 EEA22243.1 - 0.01 15.9 0.1 0.021 14.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3848) AAA PF00004.29 EEA22244.1 - 1.8e-47 161.1 0.0 7.8e-42 142.8 0.0 3.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA22244.1 - 2e-09 37.1 0.0 6.9e-09 35.4 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 EEA22244.1 - 2.7e-06 27.3 0.0 7.9e-06 25.7 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 EEA22244.1 - 6.5e-06 26.4 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA22244.1 - 8.5e-06 26.3 0.0 0.00021 21.7 0.0 3.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EEA22244.1 - 0.00038 20.5 0.0 0.0015 18.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Bromodomain PF00439.25 EEA22244.1 - 0.00074 19.5 0.0 0.0019 18.2 0.0 1.7 1 0 0 1 1 1 1 Bromodomain AAA_18 PF13238.6 EEA22244.1 - 0.0025 18.4 1.1 0.13 12.8 0.0 3.2 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 EEA22244.1 - 0.0029 17.7 0.0 0.99 9.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 EEA22244.1 - 0.0031 17.8 1.3 0.12 12.7 0.2 3.7 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EEA22244.1 - 0.0044 16.8 0.1 0.014 15.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA22244.1 - 0.0048 17.3 0.0 0.012 16.0 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 EEA22244.1 - 0.0054 16.3 0.0 0.026 14.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EEA22244.1 - 0.018 15.1 0.0 0.089 12.8 0.0 2.2 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.13 EEA22244.1 - 0.026 13.7 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Zot PF05707.12 EEA22244.1 - 0.028 14.0 0.1 12 5.5 0.1 2.8 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Mg_chelatase PF01078.21 EEA22244.1 - 0.048 13.0 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EEA22244.1 - 0.053 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EEA22244.1 - 0.071 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EEA22244.1 - 0.09 12.5 0.0 2.4 7.9 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_7 PF12775.7 EEA22244.1 - 0.11 12.0 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 EEA22244.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 EEA22244.1 - 0.12 11.2 0.2 8.8 5.1 0.2 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_11 PF13086.6 EEA22244.1 - 0.32 10.8 0.0 0.32 10.8 0.0 3.8 2 1 0 2 2 1 0 AAA domain CPSF_A PF03178.15 EEA22246.1 - 1.3e-105 353.3 0.0 6e-104 347.8 0.0 2.5 3 0 0 3 3 3 2 CPSF A subunit region MMS1_N PF10433.9 EEA22246.1 - 9.5e-20 70.7 0.0 1.6e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term LMBR1 PF04791.16 EEA22247.1 - 2.3e-18 66.4 22.1 1.9e-15 56.8 20.8 2.6 2 1 0 2 2 2 1 LMBR1-like membrane protein DUF2964 PF11177.8 EEA22247.1 - 0.0094 16.1 7.2 1.2 9.3 0.1 4.1 3 0 0 3 3 3 1 Protein of unknown function (DUF2964) Anemone_cytotox PF06369.12 EEA22247.1 - 0.03 13.9 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 Sea anemone cytotoxic protein Pox_A14 PF05767.12 EEA22247.1 - 8.1 6.7 10.9 4.8 7.4 0.1 3.9 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 GET2 PF08690.10 EEA22248.1 - 0.3 10.7 2.9 0.39 10.3 2.9 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 CEBP_ZZ PF16366.5 EEA22248.1 - 0.76 10.1 9.2 1.3 9.3 9.2 1.3 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Tubulin_3 PF14881.6 EEA22249.1 - 0.23 11.1 2.8 0.52 10.0 0.6 1.9 1 1 1 2 2 2 0 Tubulin domain RRF PF01765.19 EEA22250.1 - 8.4e-43 146.1 1.7 1.5e-42 145.3 1.7 1.4 1 0 0 1 1 1 1 Ribosome recycling factor DUF4813 PF16072.5 EEA22250.1 - 0.16 11.6 5.6 4.1 7.0 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) Cob_adeno_trans PF01923.18 EEA22250.1 - 0.16 12.1 2.3 4.5 7.4 0.3 2.4 2 1 0 2 2 2 0 Cobalamin adenosyltransferase DUF4778 PF16008.5 EEA22250.1 - 0.18 11.9 3.1 0.15 12.1 1.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) HisKA_3 PF07730.13 EEA22250.1 - 0.37 11.3 3.8 2.3 8.8 0.6 3.0 2 1 1 3 3 3 0 Histidine kinase KfrA_N PF11740.8 EEA22250.1 - 1.6 9.4 10.7 3.8 8.2 3.1 3.0 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term YtxH PF12732.7 EEA22250.1 - 4.1 8.0 9.9 1.2e+02 3.4 9.6 3.0 2 1 0 2 2 2 0 YtxH-like protein DUF1664 PF07889.12 EEA22250.1 - 5.3 7.1 7.4 1.8 8.6 2.8 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Gastrin PF00918.17 EEA22250.1 - 7.1 7.6 7.3 19 6.2 1.6 2.3 2 0 0 2 2 2 0 Gastrin/cholecystokinin family WXG100 PF06013.12 EEA22250.1 - 7.3 6.9 9.2 72 3.7 5.0 3.6 3 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF1690 PF07956.11 EEA22250.1 - 9.1 6.7 10.9 2.7 8.4 0.8 2.5 2 1 0 2 2 2 0 Protein of Unknown function (DUF1690) ANAPC_CDC26 PF10471.9 EEA22252.1 - 1.1e-18 67.8 0.1 1.3e-18 67.6 0.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Nop14 PF04147.12 EEA22252.1 - 0.0014 17.0 0.3 0.0014 17.0 0.3 1.0 1 0 0 1 1 1 1 Nop14-like family DDE_Tnp_1_7 PF13843.6 EEA22253.1 - 2.6e-51 175.0 0.1 3.8e-51 174.4 0.1 1.2 1 0 0 1 1 1 1 Transposase IS4 Fungal_trans PF04082.18 EEA22254.1 - 3.4e-09 36.1 0.4 6.4e-09 35.2 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22254.1 - 7.4e-06 26.0 7.6 1.3e-05 25.2 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FeS_assembly_P PF01883.19 EEA22255.1 - 4.8e-09 36.3 0.0 1.3e-08 34.9 0.0 1.8 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein GTP_EFTU PF00009.27 EEA22256.1 - 2.6e-48 164.1 0.0 4e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EEA22256.1 - 1.1e-36 126.1 8.3 2e-36 125.2 8.3 1.5 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EEA22256.1 - 4.5e-24 84.5 0.0 1e-23 83.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EEA22256.1 - 2.2e-19 69.3 0.0 6.2e-19 67.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EEA22256.1 - 1.7e-09 37.9 0.0 4.9e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA22256.1 - 3.2e-07 30.4 0.1 6.7e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EEA22256.1 - 3.6e-07 30.2 0.6 2.9e-06 27.3 0.0 2.5 3 0 0 3 3 3 1 Elongation Factor G, domain II Ras PF00071.22 EEA22256.1 - 0.036 13.7 0.0 0.095 12.3 0.0 1.7 1 0 0 1 1 1 0 Ras family Septin PF00735.18 EEA22256.1 - 0.064 12.5 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Septin Thiolase_N PF00108.23 EEA22257.1 - 7.5e-96 320.5 0.4 1.2e-95 319.8 0.1 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA22257.1 - 1.5e-45 153.8 2.6 1.8e-45 153.5 1.6 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EEA22257.1 - 2.7e-06 27.2 1.8 2.7e-06 27.2 1.8 2.2 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Dodecin PF07311.12 EEA22257.1 - 0.072 13.4 0.2 0.27 11.5 0.0 2.0 2 0 0 2 2 2 0 Dodecin ACP_syn_III PF08545.10 EEA22257.1 - 0.12 12.2 2.3 9.7 6.1 0.0 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Zip PF02535.22 EEA22258.1 - 3e-49 168.1 3.2 3.7e-49 167.7 3.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter MAP17 PF15807.5 EEA22258.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PsbH PF00737.20 EEA22258.1 - 0.22 11.3 4.4 0.22 11.3 0.6 2.7 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein Atg14 PF10186.9 EEA22259.1 - 6e-102 341.0 7.1 6e-102 341.0 7.1 1.6 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Not3 PF04065.15 EEA22259.1 - 0.014 14.8 5.1 0.027 13.9 5.1 1.4 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component HSP70 PF00012.20 EEA22260.1 - 6e-227 754.6 7.6 6.7e-227 754.4 7.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA22260.1 - 2.6e-16 59.3 0.1 2.8e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EEA22260.1 - 0.00033 20.4 0.0 0.00072 19.3 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain MRC1 PF09444.10 EEA22260.1 - 5 7.6 7.1 1.2 9.6 1.8 2.2 2 0 0 2 2 2 0 MRC1-like domain Bromodomain PF00439.25 EEA22261.1 - 3.3e-31 107.2 0.2 3.8e-18 65.3 0.2 2.4 2 0 0 2 2 2 2 Bromodomain Pox_Ag35 PF03286.14 EEA22261.1 - 4.6 7.0 7.6 0.45 10.3 2.9 1.7 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CKS PF01111.19 EEA22262.1 - 1.7e-34 117.9 1.8 2.2e-34 117.5 1.8 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Thioredoxin_4 PF13462.6 EEA22263.1 - 1.8e-11 44.4 0.0 3.3e-11 43.6 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EEA22263.1 - 0.18 11.6 3.2 1.2 8.9 0.2 2.7 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EEA22264.1 - 1.1e-08 35.5 0.0 1.3e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EEA22264.1 - 0.11 12.2 1.5 0.85 9.4 0.2 2.2 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF3844 PF12955.7 EEA22267.1 - 1.1e-25 89.7 5.1 2.3e-25 88.7 5.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) EGF_2 PF07974.13 EEA22267.1 - 0.016 15.6 10.3 0.035 14.5 10.3 1.6 1 1 0 1 1 1 0 EGF-like domain EGF_alliinase PF04863.13 EEA22267.1 - 0.18 12.2 11.7 0.075 13.5 8.7 1.9 2 0 0 2 2 2 0 Alliinase EGF-like domain zf-RING_2 PF13639.6 EEA22268.1 - 9.7e-13 48.2 6.4 1.5e-12 47.6 6.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA22268.1 - 7.4e-09 35.3 6.0 1.2e-08 34.7 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA22268.1 - 2.7e-08 33.4 0.9 4.5e-08 32.7 0.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EEA22268.1 - 3.5e-08 33.2 3.6 5.7e-08 32.5 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA22268.1 - 1.2e-06 28.4 3.1 1.9e-06 27.7 3.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EEA22268.1 - 4.1e-06 27.0 9.8 2e-05 24.8 9.8 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EEA22268.1 - 3.1e-05 23.9 0.9 3.1e-05 23.9 0.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EEA22268.1 - 0.00089 19.1 2.4 0.0015 18.4 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA22268.1 - 0.0014 18.6 2.8 0.004 17.2 2.8 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EEA22268.1 - 0.011 15.4 3.1 0.018 14.7 3.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EEA22268.1 - 0.037 13.8 6.1 0.062 13.1 6.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain OAD_gamma PF04277.13 EEA22268.1 - 0.038 14.6 0.1 0.6 10.7 0.0 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain PHD PF00628.29 EEA22268.1 - 0.053 13.4 5.4 0.11 12.5 5.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 EEA22268.1 - 0.065 13.4 4.6 0.13 12.4 4.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EEA22268.1 - 0.091 12.6 4.9 0.2 11.5 4.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EEA22268.1 - 0.11 12.6 3.8 0.32 11.2 3.8 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EEA22268.1 - 0.17 12.0 3.8 0.37 11.0 3.8 1.6 1 1 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.6 EEA22268.1 - 9 6.3 9.7 0.12 12.3 0.7 2.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Pro_isomerase PF00160.21 EEA22269.1 - 5.8e-51 172.9 0.9 6.7e-51 172.7 0.9 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD tRNA-synt_2c PF01411.19 EEA22270.1 - 1.6e-221 736.7 0.0 2.7e-221 735.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EEA22270.1 - 2.8e-16 59.3 0.9 6.6e-16 58.1 0.9 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EEA22270.1 - 6.6e-12 46.0 0.6 6.6e-12 46.0 0.6 2.4 2 0 0 2 2 2 1 DHHA1 domain DUF3752 PF12572.8 EEA22272.1 - 2.1e-35 122.5 6.5 2.1e-35 122.5 6.5 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF3752) Dynamitin PF04912.14 EEA22272.1 - 0.015 14.6 0.6 0.015 14.6 0.6 1.7 2 0 0 2 2 2 0 Dynamitin DUF3752 PF12572.8 EEA22273.1 - 1.7e-35 122.8 6.5 1.7e-35 122.8 6.5 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF3752) Dynamitin PF04912.14 EEA22273.1 - 0.013 14.8 0.6 0.013 14.8 0.6 1.7 2 0 0 2 2 2 0 Dynamitin RVT_1 PF00078.27 EEA22274.1 - 1.4e-13 50.9 0.0 1.8e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EEA22274.1 - 9.3e-07 29.1 0.0 2e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 RNase H zf-RVT PF13966.6 EEA22274.1 - 1.7e-05 25.4 0.0 3.3e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase DDE_1 PF03184.19 EEA22275.1 - 6.7e-34 117.0 0.0 1.3e-33 116.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22275.1 - 1.8e-09 37.5 0.0 3.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA22275.1 - 1.9e-06 27.5 0.0 3.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain RNase_H PF00075.24 EEA22277.1 - 2e-06 28.0 0.0 3.8e-06 27.1 0.0 1.5 1 1 0 1 1 1 1 RNase H zf-RVT PF13966.6 EEA22277.1 - 2.1e-05 25.1 0.0 4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase A_deaminase PF00962.22 EEA22279.1 - 1.9e-123 412.0 0.0 2.8e-123 411.4 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase F-box PF00646.33 EEA22280.1 - 8.2e-05 22.4 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EEA22280.1 - 0.0016 18.3 0.0 0.0038 17.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like DUF445 PF04286.12 EEA22280.1 - 0.95 9.2 4.6 1.6 8.5 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) AAT PF03417.16 EEA22281.1 - 1.5e-09 37.9 0.0 5.2e-08 32.9 0.0 2.1 1 1 1 2 2 2 2 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase SH3_9 PF14604.6 EEA22282.1 - 1.6e-28 98.3 6.9 4.7e-14 52.0 0.7 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EEA22282.1 - 2.4e-24 84.7 13.0 1.1e-13 50.5 0.6 2.8 3 0 0 3 3 3 2 SH3 domain SH3_2 PF07653.17 EEA22282.1 - 3.7e-17 61.7 0.1 3.5e-09 36.2 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.20 EEA22282.1 - 1.6e-16 60.2 0.0 3.5e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dynamin_M PF01031.20 EEA22283.1 - 2.8e-109 364.8 0.0 6e-109 363.7 0.0 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EEA22283.1 - 1.6e-57 194.2 1.3 6.6e-57 192.2 0.0 2.4 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 EEA22283.1 - 1.4e-31 108.4 1.3 1.4e-31 108.4 1.3 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EEA22283.1 - 9.6e-05 22.4 0.1 0.00053 20.0 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase UAA PF08449.11 EEA22284.1 - 4e-84 282.4 12.1 8.7e-59 199.2 0.7 2.1 1 1 0 2 2 2 2 UAA transporter family Nuc_sug_transp PF04142.15 EEA22284.1 - 4.6e-05 22.7 0.2 4.6e-05 22.7 0.2 1.8 2 0 0 2 2 2 1 Nucleotide-sugar transporter SLC35F PF06027.12 EEA22284.1 - 0.028 13.9 7.9 0.088 12.3 0.7 2.4 2 0 0 2 2 2 0 Solute carrier family 35 UAA PF08449.11 EEA22285.1 - 4.1e-84 282.3 12.1 8.7e-59 199.2 0.7 2.1 1 1 0 2 2 2 2 UAA transporter family Nuc_sug_transp PF04142.15 EEA22285.1 - 4.6e-05 22.7 0.2 4.6e-05 22.7 0.2 1.8 2 0 0 2 2 2 1 Nucleotide-sugar transporter SLC35F PF06027.12 EEA22285.1 - 0.028 13.9 7.9 0.088 12.3 0.7 2.4 2 0 0 2 2 2 0 Solute carrier family 35 Rad17 PF03215.15 EEA22286.1 - 8.3e-30 104.1 0.0 2e-29 102.8 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EEA22286.1 - 3.8e-05 24.2 0.0 8.4e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA22286.1 - 0.00016 22.0 0.0 0.00036 20.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EEA22286.1 - 0.00017 22.0 0.0 0.00044 20.7 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EEA22286.1 - 0.0099 15.8 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 EEA22286.1 - 0.021 15.3 0.3 0.099 13.2 0.0 2.3 2 1 0 2 2 2 0 ABC transporter T2SSE PF00437.20 EEA22286.1 - 0.023 13.8 0.0 0.048 12.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein NB-ARC PF00931.22 EEA22286.1 - 0.034 13.3 0.0 0.055 12.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EEA22286.1 - 0.043 14.2 0.0 0.097 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EEA22286.1 - 0.05 13.3 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EEA22286.1 - 0.05 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EEA22286.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EEA22286.1 - 0.15 12.1 0.0 0.41 10.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF2057 PF09829.9 EEA22286.1 - 0.22 11.7 3.8 0.49 10.5 3.8 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) AAA_11 PF13086.6 EEA22286.1 - 0.3 10.8 4.1 0.31 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain ELMO_CED12 PF04727.13 EEA22287.1 - 1.8e-53 181.3 0.1 3.1e-53 180.5 0.1 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EEA22287.1 - 1.4e-35 122.7 0.2 8.4e-34 117.0 0.2 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 EEA22287.1 - 1.4e-15 57.6 0.0 3.2e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) DUF3552 PF12072.8 EEA22287.1 - 0.071 12.5 0.5 0.13 11.7 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) PCNP PF15473.6 EEA22287.1 - 0.1 13.3 0.2 0.1 13.3 0.2 2.0 2 0 0 2 2 2 0 PEST, proteolytic signal-containing nuclear protein family Iso_dh PF00180.20 EEA22288.1 - 9.1e-86 288.1 0.0 1.1e-85 287.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF1752 PF08550.10 EEA22289.1 - 2.3e-11 43.3 4.8 4.4e-11 42.4 4.8 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) SUI1 PF01253.22 EEA22290.1 - 3.4e-24 85.1 0.3 8.3e-24 83.9 0.3 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 RNA_pol_Rpc82 PF05645.13 EEA22290.1 - 0.011 15.5 0.7 0.015 15.0 0.7 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 SUI1 PF01253.22 EEA22291.1 - 2.9e-24 85.4 0.3 7.2e-24 84.1 0.3 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 RNA_pol_Rpc82 PF05645.13 EEA22291.1 - 0.0096 15.7 0.7 0.013 15.2 0.7 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 Snapin_Pallidin PF14712.6 EEA22292.1 - 0.00089 19.6 0.5 0.0025 18.2 0.5 1.8 1 0 0 1 1 1 1 Snapin/Pallidin GAS PF13851.6 EEA22292.1 - 0.0089 15.4 2.9 0.0089 15.4 2.9 2.3 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding HOOK PF05622.12 EEA22292.1 - 0.013 13.7 3.6 0.023 12.9 3.6 1.3 1 0 0 1 1 1 0 HOOK protein BLOC1_2 PF10046.9 EEA22292.1 - 0.032 14.5 1.1 0.17 12.2 0.3 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 XhlA PF10779.9 EEA22292.1 - 0.12 12.6 1.9 0.16 12.2 0.1 2.2 2 0 0 2 2 2 0 Haemolysin XhlA DUF16 PF01519.16 EEA22292.1 - 0.13 12.7 3.6 0.18 12.3 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 GRA6 PF05084.13 EEA22292.1 - 0.14 12.1 0.0 0.14 12.1 0.0 2.6 3 0 0 3 3 3 0 Granule antigen protein (GRA6) RPW8 PF05659.11 EEA22292.1 - 0.16 11.7 1.7 1.6 8.4 0.3 2.8 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 FlaC_arch PF05377.11 EEA22292.1 - 0.34 11.3 4.2 0.16 12.4 0.6 2.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) UPF0561 PF10573.9 EEA22292.1 - 1.2 9.3 7.4 4 7.6 7.4 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Cgr1 PF03879.14 EEA22293.1 - 4.4e-34 117.1 31.1 5e-34 116.9 31.1 1.0 1 0 0 1 1 1 1 Cgr1 family VIR_N PF15912.5 EEA22293.1 - 0.7 9.4 5.8 0.78 9.3 5.8 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal RR_TM4-6 PF06459.12 EEA22293.1 - 5.8 6.6 14.0 6.1 6.6 14.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EEA22293.1 - 6.5 5.4 7.4 6.7 5.4 7.4 1.0 1 0 0 1 1 1 0 Presenilin Mito_carr PF00153.27 EEA22294.1 - 4.3e-64 212.5 1.4 9.2e-22 76.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA22294.1 - 0.0026 17.0 0.4 4.1 6.5 0.0 3.5 3 1 0 3 3 3 2 Gammaproteobacterial serine protease dCMP_cyt_deam_1 PF00383.23 EEA22295.1 - 2.2e-12 46.7 0.0 4.6e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EEA22295.1 - 7.5e-05 22.9 3.9 0.0037 17.5 0.2 3.0 3 1 0 3 3 3 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 EEA22295.1 - 0.0054 16.4 1.4 1.4 8.5 0.4 2.8 1 1 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases DUF1471 PF07338.13 EEA22295.1 - 0.36 10.8 3.3 6.7 6.8 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) HET PF06985.11 EEA22296.1 - 1.7e-05 25.2 6.8 0.0015 18.9 1.9 2.3 1 1 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Sortilin-Vps10 PF15902.5 EEA22297.1 - 1.3e-284 943.8 6.5 2e-145 485.0 3.0 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EEA22297.1 - 7.1e-95 316.1 14.5 3.6e-49 167.4 4.1 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EEA22297.1 - 1.3e-12 45.7 29.5 0.48 10.6 0.2 10.2 9 0 0 9 9 9 5 BNR/Asp-box repeat PSII_BNR PF14870.6 EEA22297.1 - 1.6e-06 27.6 2.4 0.6 9.3 0.0 4.6 4 1 0 4 4 4 3 Photosynthesis system II assembly factor YCF48 DUF2167 PF09935.9 EEA22297.1 - 0.11 11.6 0.5 0.66 9.1 0.1 2.5 3 1 1 4 4 4 0 Protein of unknown function (DUF2167) preSET_CXC PF18264.1 EEA22297.1 - 0.61 10.6 6.8 9.9 6.7 0.3 2.7 2 0 0 2 2 2 0 CXC domain Sec10 PF07393.11 EEA22299.1 - 3.3e-229 763.0 0.0 3.9e-229 762.7 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 LpxC PF03331.13 EEA22299.1 - 0.014 14.9 0.0 0.054 13.0 0.0 1.9 2 0 0 2 2 2 0 UDP-3-O-acyl N-acetylglycosamine deacetylase GCD14 PF08704.10 EEA22299.1 - 0.083 12.6 1.3 0.1 12.3 0.1 1.7 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit BP28CT PF08146.12 EEA22299.1 - 0.097 12.5 0.6 2.9 7.7 0.0 2.9 2 0 0 2 2 2 0 BP28CT (NUC211) domain Baculo_PEP_C PF04513.12 EEA22299.1 - 0.17 11.9 7.4 6 6.9 0.2 3.8 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DHquinase_I PF01487.15 EEA22302.1 - 1.8e-29 103.6 0.0 3e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EEA22302.1 - 2.5e-17 63.4 0.0 4.8e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.11 EEA22302.1 - 5.2e-13 49.0 0.0 1.4e-12 47.7 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 EEA22302.1 - 8.3e-09 35.6 0.1 2.5e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 EEA22302.1 - 3.2e-06 26.8 1.5 6e-06 25.9 1.5 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain F420_oxidored PF03807.17 EEA22302.1 - 0.021 15.4 0.0 0.057 14.0 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Fungal_trans PF04082.18 EEA22303.1 - 2.1e-22 79.4 0.0 6.9e-22 77.7 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22303.1 - 2.2e-07 30.9 14.1 4.1e-07 30.0 14.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA22304.1 - 5.4e-23 81.5 18.7 5.4e-23 81.5 18.7 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EEA22304.1 - 0.00067 18.1 10.3 0.0037 15.6 0.1 2.6 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Methyltransf_2 PF00891.18 EEA22305.1 - 1.8e-07 30.7 0.0 3e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EEA22305.1 - 0.008 16.0 0.0 0.022 14.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain WHIM1 PF15612.6 EEA22306.1 - 0.069 12.7 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 Fungal_trans_2 PF11951.8 EEA22308.1 - 7.5e-61 206.0 1.7 9.3e-61 205.7 1.7 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain VPS28 PF03997.12 EEA22308.1 - 0.031 14.0 0.1 0.062 13.0 0.1 1.4 1 0 0 1 1 1 0 VPS28 protein DAO PF01266.24 EEA22309.1 - 1.2e-46 159.9 0.0 1.4e-46 159.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA22309.1 - 4.6e-07 30.0 0.0 1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA22309.1 - 1.5e-06 27.7 0.1 0.056 12.7 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA22309.1 - 0.00012 21.3 0.1 0.042 12.9 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A Shikimate_DH PF01488.20 EEA22309.1 - 0.00034 20.7 0.0 0.00091 19.3 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EEA22309.1 - 0.00065 19.1 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EEA22309.1 - 0.0014 18.7 0.1 1 9.3 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EEA22309.1 - 0.0084 15.4 0.0 0.048 12.9 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EEA22309.1 - 0.012 15.3 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EEA22309.1 - 0.013 16.0 0.0 0.58 10.7 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 EEA22309.1 - 0.024 14.0 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 ThiF family TrkA_N PF02254.18 EEA22309.1 - 0.047 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Glu_dehyd_C PF16912.5 EEA22309.1 - 0.05 13.1 0.0 0.095 12.2 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus NAD_binding_7 PF13241.6 EEA22309.1 - 0.089 13.2 0.0 0.16 12.5 0.0 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding PglD_N PF17836.1 EEA22309.1 - 0.092 13.4 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 PglD N-terminal domain FAD_binding_2 PF00890.24 EEA22309.1 - 0.095 11.8 0.1 0.29 10.2 0.1 1.8 1 1 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EEA22309.1 - 0.1 11.8 0.0 0.22 10.7 0.0 1.5 1 0 0 1 1 1 0 Thi4 family GMC_oxred_N PF00732.19 EEA22309.1 - 0.11 11.9 0.0 4.3 6.6 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase Trp_halogenase PF04820.14 EEA22309.1 - 0.14 11.0 0.1 6.5 5.5 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.23 EEA22309.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GFO_IDH_MocA PF01408.22 EEA22309.1 - 0.18 12.6 0.0 0.37 11.6 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold MFS_1 PF07690.16 EEA22310.1 - 2.1e-36 125.6 29.4 2.9e-36 125.1 29.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA22310.1 - 0.00014 21.3 4.1 0.00014 21.3 4.1 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Hydantoinase_B PF02538.14 EEA22311.1 - 2.1e-198 659.9 0.3 2.9e-198 659.5 0.3 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EEA22311.1 - 1.3e-105 352.9 0.2 4.6e-105 351.1 0.0 2.0 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EEA22311.1 - 7.2e-63 211.5 1.9 2.5e-61 206.5 0.0 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Proteasome_A_N PF10584.9 EEA22311.1 - 0.025 14.3 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature Glyco_hydro_2_N PF02837.18 EEA22312.1 - 0.0033 17.3 0.0 0.0073 16.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Mannosidase_ig PF17786.1 EEA22312.1 - 0.0036 17.9 0.0 0.01 16.5 0.0 1.8 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Ig_GlcNase PF18368.1 EEA22312.1 - 0.022 14.9 0.0 0.093 12.9 0.0 2.0 2 0 0 2 2 2 0 Exo-beta-D-glucosaminidase Ig-fold domain Ig_mannosidase PF17753.1 EEA22312.1 - 0.037 13.8 0.0 0.084 12.6 0.0 1.6 1 0 0 1 1 1 0 Ig-fold domain GFO_IDH_MocA PF01408.22 EEA22313.1 - 4e-19 69.6 0.0 6.7e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 EEA22313.1 - 0.0031 17.8 0.0 0.0053 17.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EEA22313.1 - 0.016 15.6 0.0 0.037 14.5 0.0 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Sugar_tr PF00083.24 EEA22314.1 - 9.7e-12 44.5 0.8 1.3e-11 44.0 0.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter DUF4149 PF13664.6 EEA22314.1 - 0.037 14.4 0.6 0.16 12.3 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) MFS_1 PF07690.16 EEA22315.1 - 1.7e-33 116.0 25.5 1.7e-33 116.0 25.5 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4185 PF13810.6 EEA22317.1 - 5.5e-06 25.8 2.1 8.4e-06 25.2 2.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) adh_short_C2 PF13561.6 EEA22318.1 - 7.5e-53 179.5 0.0 9.1e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA22318.1 - 3.1e-46 157.3 0.0 3.9e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA22318.1 - 3.3e-10 40.2 0.0 4.9e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA22318.1 - 0.013 14.7 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EEA22318.1 - 0.071 12.5 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Phage_ABA_S PF18066.1 EEA22318.1 - 0.1 13.3 0.0 0.23 12.1 0.0 1.6 1 0 0 1 1 1 0 Phage ABA sandwich domain Epimerase PF01370.21 EEA22318.1 - 0.13 11.7 0.0 0.36 10.2 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pro-kuma_activ PF09286.11 EEA22319.1 - 1.6e-39 135.5 0.1 1.9e-38 132.0 0.0 2.1 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EEA22319.1 - 1.5e-05 24.5 1.5 2.2e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Subtilase family adh_short PF00106.25 EEA22320.1 - 6.4e-38 130.2 0.1 9.3e-38 129.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22320.1 - 4.8e-30 104.8 0.1 9.3e-30 103.9 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22320.1 - 6.9e-15 55.4 0.2 9.8e-15 54.9 0.2 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA22320.1 - 5.1e-08 32.4 0.1 9.4e-08 31.5 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA22320.1 - 0.0035 16.8 0.2 0.012 15.0 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pyr_redox_2 PF07992.14 EEA22320.1 - 0.013 14.8 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA22320.1 - 0.035 14.7 0.1 0.07 13.7 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3Beta_HSD PF01073.19 EEA22320.1 - 0.049 12.6 0.1 0.075 12.0 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ThiF PF00899.21 EEA22320.1 - 0.27 10.6 1.2 2.1 7.7 0.3 2.2 2 0 0 2 2 2 0 ThiF family Glyco_hydro_18 PF00704.28 EEA22322.1 - 5.8e-23 82.1 1.1 2e-22 80.3 1.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_1 PF00734.18 EEA22322.1 - 3.9e-12 45.9 7.8 3.9e-12 45.9 7.8 2.4 3 0 0 3 3 3 1 Fungal cellulose binding domain GHMP_kinases_C PF08544.13 EEA22322.1 - 0.74 10.2 2.9 5.5 7.4 2.9 2.3 1 1 0 1 1 1 0 GHMP kinases C terminal Fungal_trans PF04082.18 EEA22323.1 - 9.6e-10 37.9 0.1 1.7e-09 37.1 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain CDC45 PF02724.14 EEA22323.1 - 0.083 11.2 0.0 0.12 10.7 0.0 1.1 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.16 EEA22325.1 - 3.5e-35 121.6 83.8 2.3e-34 118.9 62.9 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA22325.1 - 1.3e-21 76.7 30.7 1.8e-21 76.2 30.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA22325.1 - 7.2e-13 48.2 3.5 7.2e-13 48.2 3.5 2.8 2 1 0 3 3 3 2 Sugar (and other) transporter DUF3522 PF12036.8 EEA22325.1 - 0.022 15.0 1.6 0.022 15.0 1.6 3.3 2 2 0 2 2 2 0 Protein of unknown function (DUF3522) Gly-zipper_YMGG PF13441.6 EEA22325.1 - 0.76 9.6 3.6 7.5 6.4 0.0 2.7 2 0 0 2 2 2 0 YMGG-like Gly-zipper OATP PF03137.20 EEA22325.1 - 4.4 5.5 24.3 0.038 12.3 4.5 4.0 4 1 0 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family Ses_B PF17046.5 EEA22326.1 - 5.8e-10 38.9 3.7 5.8e-10 38.9 3.7 1.7 2 0 0 2 2 2 1 SesB domain on fungal death-pathway protein DUF676 PF05057.14 EEA22326.1 - 1.4e-08 34.6 0.0 2.4e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EEA22326.1 - 1.9e-05 25.4 0.0 2.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EEA22326.1 - 0.00019 21.3 0.0 0.00035 20.4 0.0 1.4 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_9 PF10081.9 EEA22326.1 - 0.0086 15.2 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta-hydrolase family DUF726 PF05277.12 EEA22326.1 - 0.16 10.9 0.0 0.28 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) HeLo PF14479.6 EEA22327.1 - 1e-35 123.5 1.0 1e-35 123.5 1.0 2.5 2 1 0 2 2 2 1 Prion-inhibition and propagation Goodbye PF17109.5 EEA22327.1 - 5.5e-16 59.1 5.6 1.5e-14 54.5 0.1 3.6 4 0 0 4 4 4 2 fungal STAND N-terminal Goodbye domain Ses_B PF17046.5 EEA22327.1 - 4e-06 26.7 7.0 4e-06 26.7 7.0 1.9 2 0 0 2 2 2 1 SesB domain on fungal death-pathway protein Sec34 PF04136.15 EEA22327.1 - 0.82 9.5 6.7 0.96 9.3 0.5 3.4 3 1 0 3 3 3 0 Sec34-like family TPR_12 PF13424.6 EEA22328.1 - 7.3e-152 494.0 56.8 3.2e-23 81.8 0.2 9.4 2 1 7 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 EEA22328.1 - 1.7e-144 466.4 22.4 2.1e-15 56.0 0.1 12.3 12 0 0 12 12 12 12 Tetratricopeptide repeat TPR_7 PF13176.6 EEA22328.1 - 6.1e-40 132.3 20.5 0.00021 21.1 0.0 11.6 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_1 PF00515.28 EEA22328.1 - 2.8e-32 109.2 29.0 2.8e-05 23.7 0.1 11.6 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 EEA22328.1 - 5.8e-19 66.6 32.6 0.012 15.6 0.2 12.0 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_4 PF07721.14 EEA22328.1 - 1.4e-18 65.6 0.0 0.32 11.7 0.0 10.2 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA22328.1 - 1.5e-17 62.8 16.8 1.6 9.8 0.0 11.4 10 1 1 11 11 11 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA22328.1 - 5.1e-16 59.0 24.0 2.5e-08 33.7 5.7 4.5 1 1 4 5 5 5 5 MalT-like TPR region TPR_8 PF13181.6 EEA22328.1 - 2.7e-14 52.1 29.6 0.22 11.8 0.1 11.8 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA22328.1 - 3.6e-13 49.9 25.1 0.0014 19.3 0.2 9.7 5 3 6 11 11 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA22328.1 - 1.4e-10 41.2 8.8 0.0075 16.5 0.1 8.0 3 2 6 9 9 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EEA22328.1 - 1.6e-10 41.3 25.6 0.021 15.3 0.3 6.8 5 1 1 6 6 6 4 Tetratricopeptide repeat NB-ARC PF00931.22 EEA22328.1 - 9e-09 34.9 0.0 2.4e-07 30.2 0.0 2.3 1 1 0 1 1 1 1 NB-ARC domain TPR_17 PF13431.6 EEA22328.1 - 3.2e-07 30.3 9.7 7.7 7.1 0.1 9.8 11 0 0 11 11 11 1 Tetratricopeptide repeat DUF1925 PF09094.11 EEA22328.1 - 8.5e-05 22.8 10.3 5.6 7.3 0.1 8.8 8 2 2 10 10 10 1 Domain of unknown function (DUF1925) DUF3326 PF11805.8 EEA22328.1 - 0.00059 18.8 4.1 0.064 12.1 0.7 3.7 1 1 2 5 5 5 1 Protein of unknown function (DUF3326) Ses_B PF17046.5 EEA22328.1 - 0.0006 19.7 3.1 0.0012 18.7 3.1 1.5 1 0 0 1 1 1 1 SesB domain on fungal death-pathway protein NACHT PF05729.12 EEA22328.1 - 0.0032 17.4 0.0 0.0085 16.0 0.0 1.8 1 0 0 1 1 1 1 NACHT domain MIT PF04212.18 EEA22328.1 - 0.0033 17.5 17.3 3.2 7.9 0.0 8.7 8 2 3 11 11 9 1 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 EEA22328.1 - 3.7 7.6 28.4 6.8 6.8 0.0 8.1 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA22328.1 - 6.4 7.6 19.2 7.3 7.5 0.1 8.3 10 1 0 10 10 7 0 Tetratricopeptide repeat adh_short PF00106.25 EEA22329.1 - 3.3e-22 78.9 0.1 1.5e-17 63.7 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22329.1 - 3.3e-14 53.0 0.0 2.8e-10 40.2 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22329.1 - 1.6e-06 28.2 0.0 2.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA22329.1 - 0.0079 15.4 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EEA22329.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase MFS_1 PF07690.16 EEA22331.1 - 7.6e-36 123.8 24.8 1.1e-24 87.0 7.0 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EEA22331.1 - 7.9e-07 27.7 4.8 1.9e-05 23.2 4.8 2.6 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 EEA22331.1 - 5.5e-05 21.9 13.1 0.0058 15.2 9.7 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_3 PF05977.13 EEA22331.1 - 0.011 14.1 11.3 0.0092 14.4 8.7 1.9 2 0 0 2 2 2 0 Transmembrane secretion effector Peptidase_A4 PF01828.17 EEA22332.1 - 1.8e-69 233.4 17.7 2.4e-69 233.0 17.7 1.2 1 0 0 1 1 1 1 Peptidase A4 family DHFR_2 PF06442.11 EEA22332.1 - 0.016 15.1 0.2 0.04 13.7 0.2 1.7 1 0 0 1 1 1 0 R67 dihydrofolate reductase DUF1869 PF08956.10 EEA22332.1 - 0.073 13.0 1.1 2.8 7.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) UPF0561 PF10573.9 EEA22332.1 - 0.71 10.0 2.3 0.38 10.9 0.3 1.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 Pyr_redox_2 PF07992.14 EEA22333.1 - 8.2e-43 146.7 0.1 1.3e-42 146.1 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA22333.1 - 1.8e-16 60.4 1.8 1.7e-15 57.4 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EEA22333.1 - 4.2e-16 59.2 0.0 8e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 EEA22333.1 - 2.9e-05 23.5 0.6 0.00076 18.8 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA22333.1 - 3.3e-05 22.8 4.7 0.15 10.7 0.1 3.2 2 1 1 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 EEA22333.1 - 0.00033 19.8 1.9 0.35 9.9 0.0 3.3 3 0 0 3 3 3 2 Lycopene cyclase protein Fungal_trans_2 PF11951.8 EEA22333.1 - 0.00043 19.2 0.2 0.00087 18.2 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_binding_7 PF13241.6 EEA22333.1 - 0.0018 18.7 0.3 0.58 10.6 0.1 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding GIDA PF01134.22 EEA22333.1 - 0.0026 16.9 3.8 0.31 10.1 0.2 2.8 2 1 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EEA22333.1 - 0.004 16.4 0.2 0.04 13.1 0.0 2.4 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EEA22333.1 - 0.0056 16.0 0.7 1.5 8.0 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA22333.1 - 0.018 15.3 1.2 1.8 8.9 0.1 3.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain XdhC_C PF13478.6 EEA22333.1 - 0.024 15.1 0.0 0.41 11.2 0.0 2.7 2 0 0 2 2 2 0 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 EEA22333.1 - 0.036 13.4 0.0 0.1 12.0 0.0 1.8 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA22333.1 - 0.18 11.7 2.4 0.23 11.3 0.1 2.4 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EEA22333.1 - 0.37 10.1 2.0 0.36 10.1 0.4 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EEA22333.1 - 0.65 9.5 3.5 3.9 7.0 0.1 2.8 2 1 1 3 3 3 0 FAD dependent oxidoreductase DDE_1 PF03184.19 EEA22334.1 - 5.6e-23 81.5 0.0 1.1e-22 80.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22334.1 - 9.1e-09 35.2 0.3 3.1e-08 33.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Amidase PF01425.21 EEA22334.1 - 0.055 12.4 1.6 0.083 11.8 1.6 1.2 1 0 0 1 1 1 0 Amidase CRAL_TRIO PF00650.20 EEA22335.1 - 9.5e-25 87.2 0.0 2.1e-24 86.0 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA22335.1 - 0.00015 21.9 0.0 0.00045 20.3 0.0 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Ribosomal_L10 PF00466.20 EEA22335.1 - 0.092 12.9 0.1 0.47 10.6 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L10 CRAL_TRIO_2 PF13716.6 EEA22335.1 - 0.1 12.8 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Glyco_hydro_3 PF00933.21 EEA22336.1 - 3.7e-54 184.2 0.0 4.5e-54 184.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Mucin PF01456.17 EEA22337.1 - 0.023 14.7 11.2 0.032 14.2 11.2 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Beta-APP PF03494.13 EEA22337.1 - 0.041 13.7 5.5 0.077 12.9 5.5 1.4 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) DUF3431 PF11913.8 EEA22338.1 - 5.8e-87 291.0 0.1 7.2e-87 290.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) MRAP PF15183.6 EEA22338.1 - 1 9.3 3.2 0.4 10.6 0.4 1.8 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family DEAD PF00270.29 EEA22339.1 - 2.1e-46 157.9 0.0 1.9e-45 154.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA22339.1 - 2.1e-25 89.2 0.0 9.9e-25 87.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA22339.1 - 1.9e-19 69.6 0.1 3.5e-19 68.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ERCC3_RAD25_C PF16203.5 EEA22339.1 - 0.00074 18.8 0.0 0.00074 18.8 0.0 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase RNA_pol_A_CTD PF03118.15 EEA22339.1 - 0.036 13.8 0.0 0.14 11.9 0.0 2.0 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain Spore_coat_CotO PF14153.6 EEA22339.1 - 6.9 6.6 15.6 13 5.7 15.6 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Peptidase_S64 PF08192.11 EEA22341.1 - 4.8e-06 25.4 0.0 8.3e-06 24.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S64 4HBT_3 PF13622.6 EEA22342.1 - 2.5e-39 136.0 0.0 2.9e-39 135.8 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 EEA22342.1 - 0.022 14.1 0.1 0.15 11.4 0.0 2.2 3 0 0 3 3 3 0 Acyl-ACP thioesterase 4HBT PF03061.22 EEA22342.1 - 0.1 12.9 0.0 0.46 10.9 0.0 2.1 2 1 0 2 2 2 0 Thioesterase superfamily Glyco_transf_8 PF01501.20 EEA22343.1 - 4.9e-13 49.2 0.0 1.1e-12 48.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 MFS_2 PF13347.6 EEA22344.1 - 6.3e-10 38.2 4.5 6.3e-10 38.2 4.5 3.0 1 1 0 3 3 3 1 MFS/sugar transport protein PUCC PF03209.15 EEA22344.1 - 0.00021 20.4 0.5 0.00036 19.7 0.5 1.5 1 0 0 1 1 1 1 PUCC protein MFS_2 PF13347.6 EEA22345.1 - 6.3e-10 38.2 4.5 6.3e-10 38.2 4.5 3.0 1 1 0 3 3 3 1 MFS/sugar transport protein PUCC PF03209.15 EEA22345.1 - 0.00021 20.4 0.5 0.00036 19.7 0.5 1.5 1 0 0 1 1 1 1 PUCC protein Hydantoinase_B PF02538.14 EEA22346.1 - 8e-17 60.8 0.1 8.9e-17 60.7 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase MFS_1 PF07690.16 EEA22348.1 - 1.2e-44 152.7 47.7 4.7e-44 150.7 47.2 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA22348.1 - 2.3e-11 42.8 25.3 4.4e-11 41.9 25.3 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DIOX_N PF14226.6 EEA22350.1 - 3.1e-09 37.6 0.0 4.3e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal VHL_C PF17211.3 EEA22350.1 - 0.15 12.1 0.2 0.41 10.7 0.1 1.8 2 0 0 2 2 2 0 VHL box domain CBM_1 PF00734.18 EEA22352.1 - 5.3e-15 55.1 9.5 5.3e-15 55.1 9.5 3.1 3 0 0 3 3 3 1 Fungal cellulose binding domain DPBB_1 PF03330.18 EEA22352.1 - 1.1e-06 28.8 0.6 1.1e-06 28.8 0.6 2.3 2 0 0 2 2 2 1 Lytic transglycolase MFS_1 PF07690.16 EEA22353.1 - 2.1e-41 142.0 53.3 2.1e-41 142.0 53.3 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA22353.1 - 1.6e-13 50.0 37.5 1.1e-12 47.2 37.5 1.9 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Cys_Met_Meta_PP PF01053.20 EEA22354.1 - 1e-30 106.6 0.0 1.3e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EEA22354.1 - 0.005 16.1 0.0 0.0075 15.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Transp_cyt_pur PF02133.15 EEA22355.1 - 1.1e-92 311.1 50.6 1.3e-92 310.9 50.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin RVT_1 PF00078.27 EEA22356.1 - 1.1e-34 119.9 0.0 2.3e-34 118.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAT PF03417.16 EEA22356.1 - 5.4e-23 81.9 0.0 1.2e-22 80.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase zf-RVT PF13966.6 EEA22356.1 - 0.081 13.6 0.1 0.081 13.6 0.1 2.7 3 0 0 3 3 3 0 zinc-binding in reverse transcriptase RVT_2 PF07727.14 EEA22357.1 - 2.9e-38 131.9 0.2 4.8e-38 131.2 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA22357.1 - 1.7e-07 31.0 0.0 4.1e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA22357.1 - 0.00043 20.4 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA22357.1 - 0.022 14.3 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA22357.1 - 0.066 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA22357.1 - 0.1 12.9 3.2 0.27 11.5 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein REV1_C PF16727.5 EEA22358.1 - 0.081 13.3 3.6 3.4 8.1 0.3 2.5 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA22358.1 - 0.9 9.3 6.0 0.29 11.0 0.2 2.6 3 0 0 3 3 3 0 Sulfotransferase domain Glyco_hydro_18 PF00704.28 EEA22359.1 - 5.4e-15 55.9 0.6 4.4e-14 52.9 0.6 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 EEA22359.1 - 2.8e-10 40.0 11.1 2.8e-10 40.0 11.1 3.9 1 1 1 2 2 2 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 EEA22359.1 - 0.46 10.7 4.8 1.4 9.2 4.8 1.9 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Retrotrans_gag PF03732.17 EEA22360.1 - 1.2e-06 28.7 0.2 1.2e-06 28.7 0.2 2.1 2 1 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.5 EEA22360.1 - 3.8e-05 23.5 0.0 7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC PF00098.23 EEA22360.1 - 0.055 13.6 0.6 0.095 12.8 0.6 1.4 1 0 0 1 1 1 0 Zinc knuckle Fez1 PF06818.15 EEA22360.1 - 0.18 12.3 9.0 0.093 13.2 6.2 1.8 2 0 0 2 2 2 0 Fez1 BBP1_C PF15272.6 EEA22360.1 - 0.24 11.2 17.0 0.043 13.7 9.8 2.7 3 1 0 3 3 3 0 Spindle pole body component BBP1, C-terminal FAM167 PF11652.8 EEA22360.1 - 0.28 11.7 6.9 3.6 8.1 1.0 2.5 1 1 1 2 2 2 0 FAM167 ALMT PF11744.8 EEA22360.1 - 0.28 9.9 5.1 0.44 9.3 5.1 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Phage_Gp23 PF10669.9 EEA22360.1 - 0.41 11.0 4.7 0.89 9.9 4.7 1.5 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Atg14 PF10186.9 EEA22360.1 - 0.87 8.6 7.2 0.45 9.6 4.1 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2570 PF10828.8 EEA22360.1 - 0.92 9.4 7.6 1.3 8.9 6.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) APG6_N PF17675.1 EEA22360.1 - 1.7 9.2 14.4 0.91 10.0 8.4 2.6 3 0 0 3 3 2 0 Apg6 coiled-coil region TAF4 PF05236.14 EEA22360.1 - 2.3 7.9 15.1 0.17 11.6 7.6 2.3 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family USP8_interact PF08941.10 EEA22360.1 - 2.4 8.0 7.2 0.85 9.4 3.5 2.0 1 1 1 2 2 2 0 USP8 interacting RT_RNaseH PF17917.1 EEA22361.1 - 1.1e-33 115.6 0.0 2.3e-33 114.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EEA22361.1 - 2.1e-30 104.7 0.0 6.2e-30 103.2 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EEA22361.1 - 3.5e-21 75.7 0.1 7.6e-21 74.6 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chromo PF00385.24 EEA22362.1 - 2.1e-13 50.0 2.3 3.4e-12 46.1 4.3 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF5457 PF17540.2 EEA22362.1 - 0.15 12.2 0.5 0.31 11.2 0.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5457) 2OG-FeII_Oxy_3 PF13640.6 EEA22364.1 - 1.6e-07 32.1 0.1 3.3e-07 31.1 0.1 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3328 PF11807.8 EEA22365.1 - 1.1e-14 54.8 0.2 1.6e-14 54.2 0.2 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EEA22366.1 - 7.6e-52 176.3 0.0 1e-51 175.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) PEX-2N PF09263.10 EEA22367.1 - 0.16 12.4 0.2 13 6.2 0.0 2.5 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal MtrG PF04210.13 EEA22367.1 - 8.5 6.3 10.1 12 5.8 1.5 2.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Glyco_hydro_10 PF00331.20 EEA22369.1 - 5.5e-102 341.1 0.0 6.4e-102 340.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.18 EEA22369.1 - 1.2e-13 50.8 10.0 1.2e-13 50.8 10.0 2.4 2 0 0 2 2 2 1 Fungal cellulose binding domain DUF4269 PF14091.6 EEA22369.1 - 0.049 13.9 0.0 0.083 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) Sporozoite_P67 PF05642.11 EEA22369.1 - 2.3 6.2 5.2 3.2 5.7 5.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ABC_tran PF00005.27 EEA22370.1 - 2e-27 96.3 0.2 5.3e-18 65.8 0.0 2.8 2 1 0 2 2 2 2 ABC transporter AAA_33 PF13671.6 EEA22370.1 - 2.3e-05 24.6 0.1 0.16 12.1 0.0 2.6 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EEA22370.1 - 2.3e-05 24.9 0.1 0.11 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EEA22370.1 - 9.2e-05 22.7 0.9 0.56 10.5 0.2 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EEA22370.1 - 0.00021 21.0 4.0 0.26 11.0 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 EEA22370.1 - 0.00028 21.0 1.8 0.021 14.9 0.2 2.3 2 0 0 2 2 2 1 Dynamin family AAA_25 PF13481.6 EEA22370.1 - 0.00039 20.0 2.1 0.38 10.3 0.1 2.6 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EEA22370.1 - 0.00089 19.3 0.6 2.1 8.5 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EEA22370.1 - 0.0015 18.4 0.2 0.1 12.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EEA22370.1 - 0.0025 18.0 2.9 0.15 12.1 0.4 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_24 PF13479.6 EEA22370.1 - 0.0031 17.3 0.7 0.59 9.8 0.1 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EEA22370.1 - 0.0041 17.1 0.6 0.48 10.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 EEA22370.1 - 0.0066 16.4 0.3 3 7.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EEA22370.1 - 0.012 15.9 0.3 5.3 7.4 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EEA22370.1 - 0.026 13.9 1.2 2 7.7 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 EEA22370.1 - 0.049 12.7 1.3 4.4 6.3 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein RNA_helicase PF00910.22 EEA22370.1 - 0.066 13.6 0.1 18 5.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase TsaE PF02367.17 EEA22370.1 - 0.067 13.2 3.1 1 9.4 0.1 2.7 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EEA22370.1 - 0.13 11.9 1.7 12 5.4 0.4 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EEA22370.1 - 0.13 11.4 1.1 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 EEA22370.1 - 0.31 11.5 4.8 9.7 6.6 0.7 2.4 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EEA22370.1 - 0.38 10.5 5.2 1.1 8.9 0.3 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EEA22370.1 - 0.4 10.2 1.4 5.2 6.5 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EEA22370.1 - 0.42 10.6 1.3 8.4 6.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 EEA22370.1 - 0.61 9.7 1.7 19 4.8 0.3 2.2 2 0 0 2 2 2 0 AAA ATPase domain Pox_A32 PF04665.12 EEA22370.1 - 1.4 8.3 3.3 17 4.8 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein SMC_N PF02463.19 EEA22370.1 - 2.2 7.7 3.7 14 5.1 0.2 3.0 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain Sugar_tr PF00083.24 EEA22371.1 - 4.1e-91 306.1 20.2 4.9e-91 305.8 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA22371.1 - 5.2e-29 101.3 18.5 7.7e-29 100.7 18.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EEA22371.1 - 0.01 14.2 11.8 0.2 9.9 3.8 3.1 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family YtpI PF14007.6 EEA22371.1 - 5 7.3 10.3 0.4 10.9 1.4 3.3 3 0 0 3 3 3 0 YtpI-like protein ECH_1 PF00378.20 EEA22372.1 - 6e-35 120.8 0.9 2e-22 79.7 0.8 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA22372.1 - 2.2e-12 47.1 0.0 4.6e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase NmrA PF05368.13 EEA22373.1 - 1.7e-32 112.8 0.0 2e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA22373.1 - 1.8e-08 34.5 0.0 2.8e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA22373.1 - 0.00086 18.8 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EEA22373.1 - 0.017 15.0 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 KR domain Sacchrp_dh_NADP PF03435.18 EEA22373.1 - 0.16 12.2 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ADH_N PF08240.12 EEA22374.1 - 2.4e-10 40.3 0.2 1.1e-09 38.2 0.1 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA22374.1 - 1.2e-08 35.0 0.0 5.5e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase HTH_51 PF18558.1 EEA22375.1 - 2.9e-30 104.0 0.0 2e-29 101.3 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain NAD_binding_4 PF07993.12 EEA22375.1 - 6.6e-20 71.4 0.0 2.3e-19 69.6 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein PP-binding PF00550.25 EEA22375.1 - 1.9e-08 34.5 0.0 4.4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EEA22375.1 - 1.6e-05 24.5 0.0 2.9e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA22375.1 - 0.0027 16.9 0.0 0.21 10.7 0.0 2.3 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Zn_clus PF00172.18 EEA22376.1 - 2.8e-08 33.7 12.5 5.4e-08 32.8 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA22376.1 - 2.4e-06 26.8 0.0 4.9e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EEA22377.1 - 3.5e-20 72.3 20.9 5.1e-20 71.7 20.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TauD PF02668.16 EEA22378.1 - 3.8e-50 171.2 0.0 4.7e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family HTH_psq PF05225.16 EEA22379.1 - 2e-06 27.4 0.1 4.4e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.6 EEA22379.1 - 0.0025 17.9 0.1 0.013 15.6 0.0 2.3 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 EEA22379.1 - 0.035 13.9 0.3 0.087 12.7 0.3 1.7 1 1 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 EEA22379.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Aldo_ket_red PF00248.21 EEA22380.1 - 5.6e-67 226.0 0.0 6.3e-67 225.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Zn_clus PF00172.18 EEA22381.1 - 1e-07 31.9 7.5 1.8e-07 31.2 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA22381.1 - 4.6e-06 25.9 0.3 9.1e-06 24.9 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MmgE_PrpD PF03972.14 EEA22381.1 - 0.1 11.1 0.1 0.64 8.5 0.0 1.9 2 0 0 2 2 2 0 MmgE/PrpD family Epimerase PF01370.21 EEA22382.1 - 2.6e-08 33.6 0.0 0.00048 19.7 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA22382.1 - 6.5e-05 22.9 0.0 0.00018 21.4 0.0 1.8 2 1 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EEA22382.1 - 0.00011 21.9 0.0 0.016 14.7 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family Semialdhyde_dh PF01118.24 EEA22382.1 - 0.0034 17.8 0.0 0.0063 16.9 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EEA22382.1 - 0.0036 16.5 0.0 0.016 14.3 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EEA22382.1 - 0.0053 16.7 0.0 0.0096 15.8 0.0 1.5 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EEA22382.1 - 0.0053 16.2 0.1 0.56 9.5 0.1 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EEA22382.1 - 0.015 14.3 0.0 0.043 12.8 0.0 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EEA22382.1 - 0.03 13.5 0.0 0.95 8.6 0.0 2.2 2 0 0 2 2 2 0 Male sterility protein Shikimate_DH PF01488.20 EEA22382.1 - 0.19 11.8 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GDPD_2 PF13653.6 EEA22383.1 - 0.00088 19.7 0.2 0.0024 18.3 0.2 1.8 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Asp PF00026.23 EEA22386.1 - 1.9e-52 178.7 0.0 2.2e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA22386.1 - 2.8e-06 27.9 0.0 0.15 12.8 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 EEA22386.1 - 0.0072 16.6 0.0 1.2 9.3 0.0 2.7 3 0 0 3 3 3 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EEA22386.1 - 0.015 15.9 0.0 2.5 8.7 0.0 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease FluMu_N PF17891.1 EEA22388.1 - 0.005 16.6 0.1 0.057 13.2 0.0 2.0 2 0 0 2 2 2 1 Mu-like prophage FluMu N-terminal domain ketoacyl-synt PF00109.26 EEA22389.1 - 5.4e-78 262.1 0.0 9.7e-78 261.2 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA22389.1 - 1e-56 191.7 0.2 2.4e-56 190.5 0.2 1.7 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EEA22389.1 - 3.7e-52 177.4 0.8 7.4e-52 176.4 0.8 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EEA22389.1 - 2.5e-47 162.0 0.1 5.2e-47 160.9 0.1 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA22389.1 - 8e-34 116.2 0.5 4.6e-33 113.7 0.5 2.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EEA22389.1 - 1.2e-18 67.6 0.0 3.4e-18 66.1 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EEA22389.1 - 2.6e-17 63.0 0.1 2e-16 60.1 0.0 2.6 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA22389.1 - 1.1e-14 55.7 0.0 8.8e-14 52.7 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EEA22389.1 - 1e-13 51.2 0.1 8e-13 48.3 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22389.1 - 1.1e-06 28.4 0.0 2.8e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EEA22389.1 - 3.9e-06 26.7 0.1 9.6e-06 25.4 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EEA22389.1 - 1.5e-05 25.2 0.0 7e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EEA22389.1 - 0.00054 19.4 0.0 0.0015 18.0 0.0 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain Shikimate_DH PF01488.20 EEA22389.1 - 0.026 14.6 0.0 5.9 7.0 0.0 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PH_17 PF18012.1 EEA22389.1 - 0.12 12.1 0.1 0.32 10.8 0.1 1.7 1 0 0 1 1 1 0 PH domain Thioesterase PF00975.20 EEA22390.1 - 2.4e-18 67.1 0.0 3.8e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 EEA22390.1 - 7.6e-07 29.4 0.1 1.3e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.7 EEA22390.1 - 7.6e-05 23.4 0.1 0.00012 22.7 0.1 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EEA22390.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Methyltransf_2 PF00891.18 EEA22391.1 - 1.1e-18 67.3 0.0 1.5e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 EEA22391.1 - 0.00093 19.9 0.0 0.0021 18.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA22391.1 - 0.00094 19.8 0.0 0.002 18.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DSBA PF01323.20 EEA22392.1 - 6.4e-29 101.1 0.0 7.2e-29 100.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain FAD_binding_3 PF01494.19 EEA22393.1 - 2.1e-20 73.3 1.1 2.5e-19 69.7 1.1 2.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA22393.1 - 4.4e-10 39.6 1.8 2.3e-09 37.3 1.4 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA22393.1 - 5e-06 26.0 1.1 0.0004 19.7 0.2 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA22393.1 - 0.00032 19.9 4.0 0.0007 18.8 4.0 1.6 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA22393.1 - 0.00049 19.8 3.5 0.00069 19.3 3.3 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA22393.1 - 0.00093 19.7 1.7 0.0019 18.7 0.8 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA22393.1 - 0.0018 17.4 3.2 0.0024 17.0 3.2 1.3 1 1 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EEA22393.1 - 0.0062 15.9 1.1 0.01 15.3 1.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA22393.1 - 0.0078 15.0 2.1 0.013 14.3 2.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Trp_halogenase PF04820.14 EEA22393.1 - 0.01 14.7 1.2 0.061 12.2 0.5 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Thi4 PF01946.17 EEA22393.1 - 0.022 14.0 1.1 0.044 13.0 1.1 1.5 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EEA22393.1 - 0.026 13.8 1.8 0.061 12.6 1.8 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EEA22393.1 - 0.057 12.7 0.3 0.29 10.4 0.1 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EEA22393.1 - 0.12 11.5 1.5 0.21 10.8 1.5 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ketoacyl-synt PF00109.26 EEA22394.1 - 2.4e-71 240.3 0.1 4.5e-71 239.4 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EEA22394.1 - 1e-50 172.7 0.0 3e-50 171.2 0.0 1.8 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EEA22394.1 - 5.9e-34 118.0 0.0 1e-33 117.2 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA22394.1 - 3.4e-33 114.2 0.1 1e-32 112.6 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EEA22394.1 - 3.6e-16 59.3 0.2 9.5e-16 57.9 0.1 1.7 2 0 0 2 2 2 1 Polyketide synthase dehydratase PP-binding PF00550.25 EEA22394.1 - 7.8e-11 42.2 0.3 2.4e-10 40.6 0.3 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thioesterase PF00975.20 EEA22394.1 - 3.9e-08 33.7 0.0 1.1e-07 32.3 0.0 1.8 1 0 0 1 1 1 1 Thioesterase domain KAsynt_C_assoc PF16197.5 EEA22394.1 - 0.0013 19.2 1.0 0.0042 17.5 0.0 2.5 3 0 0 3 3 3 1 Ketoacyl-synthetase C-terminal extension ANTAR PF03861.14 EEA22394.1 - 0.047 13.5 0.4 3.7 7.5 0.1 2.7 2 0 0 2 2 2 0 ANTAR domain Thiolase_N PF00108.23 EEA22394.1 - 0.08 12.3 1.3 0.16 11.3 1.3 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain Trp_halogenase PF04820.14 EEA22395.1 - 9.9e-29 100.5 0.2 3e-14 52.7 0.3 2.1 2 0 0 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 EEA22395.1 - 1.1e-08 34.7 0.1 5.4e-06 25.9 0.0 2.5 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA22395.1 - 1.6e-05 25.0 0.1 7.9e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA22395.1 - 2.8e-05 23.5 0.0 5.5e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA22395.1 - 4.1e-05 22.5 0.0 0.00021 20.1 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EEA22395.1 - 8.4e-05 21.8 0.0 0.00014 21.1 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EEA22395.1 - 0.00021 20.8 0.1 0.00032 20.2 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA22395.1 - 0.00036 19.7 0.1 0.00071 18.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA22395.1 - 0.00066 19.4 0.1 0.0037 16.9 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA22395.1 - 0.0024 17.2 0.0 0.031 13.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EEA22395.1 - 0.047 13.9 0.1 7.6 6.8 0.0 2.6 3 0 0 3 3 3 0 TrkA-N domain Pyr_redox PF00070.27 EEA22395.1 - 0.049 14.2 0.0 0.13 12.8 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA22395.1 - 0.089 12.0 0.2 0.28 10.4 0.0 1.9 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.12 EEA22395.1 - 0.095 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Zn_clus PF00172.18 EEA22396.1 - 0.00022 21.3 10.1 0.00044 20.3 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA22397.1 - 4.6e-42 144.2 50.1 2.1e-41 142.0 50.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 EEA22398.1 - 7.1e-08 32.4 3.7 7.1e-08 32.4 3.7 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ACP_PD PF04336.12 EEA22399.1 - 0.026 14.9 1.2 0.08 13.4 0.3 2.1 1 1 1 2 2 2 0 Acyl carrier protein phosphodiesterase Styelin PF17562.2 EEA22399.1 - 0.23 11.8 3.2 12 6.4 0.8 3.3 4 0 0 4 4 4 0 Styelin OrsD PF12013.8 EEA22400.1 - 2.2e-07 31.3 0.0 6.7e-07 29.8 0.0 1.7 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EEA22403.1 - 5.7e-13 49.3 0.0 1.5e-12 47.9 0.0 1.7 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA22404.1 - 3.9e-14 52.8 0.1 9e-14 51.6 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA22404.1 - 2.4e-13 50.4 0.0 6e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA22404.1 - 5.6e-06 26.5 0.0 1.9e-05 24.7 0.0 2.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit OrsD PF12013.8 EEA22405.1 - 3.9e-12 46.6 12.4 4.2e-12 46.5 9.6 2.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D Helicase_C PF00271.31 EEA22405.1 - 8.2e-12 45.4 0.0 1e-10 41.9 0.0 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA22405.1 - 4.6e-11 42.8 0.0 1.7e-10 41.0 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA22405.1 - 0.00085 19.4 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EEA22405.1 - 0.016 15.9 0.1 0.058 14.1 0.1 2.0 1 0 0 1 1 1 0 RecQ zinc-binding zf-C2H2_12 PF18658.1 EEA22405.1 - 0.035 13.7 3.0 0.19 11.3 3.0 2.3 1 0 0 1 1 1 0 Zinc-finger C2H2-type Peptidase_S8 PF00082.22 EEA22405.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Subtilase family RVT_2 PF07727.14 EEA22406.1 - 3.6e-61 206.9 0.0 5.5e-61 206.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA22406.1 - 2.7e-17 63.0 0.0 1.4e-16 60.8 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EEA22406.1 - 7.6e-10 38.5 0.2 3.9e-09 36.2 0.1 2.3 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 EEA22406.1 - 0.0086 15.8 0.1 0.045 13.5 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 EEA22406.1 - 0.092 12.2 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA22407.1 - 2.6e-19 69.2 0.8 2.6e-19 69.2 0.8 2.4 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EEA22407.1 - 0.0021 17.6 1.1 0.0032 17.0 0.3 1.7 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF4300 PF14133.6 EEA22407.1 - 0.078 12.7 0.2 0.14 11.8 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) gag_pre-integrs PF13976.6 EEA22409.1 - 2.9e-09 36.6 0.1 6.2e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA22409.1 - 1.4e-05 25.2 0.3 4.1e-05 23.8 0.1 1.8 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 EEA22410.1 - 3.2e-18 66.0 0.2 6.8e-18 64.9 0.2 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EEA22410.1 - 7.6e-17 61.6 0.0 1.6e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 EEA22410.1 - 2.9e-05 24.0 0.0 0.0001 22.2 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Asp PF00026.23 EEA22411.1 - 8.2e-55 186.4 0.0 9.7e-55 186.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA22411.1 - 0.0024 18.1 0.0 2.8 8.2 0.0 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA22411.1 - 0.025 15.2 0.1 3.2 8.5 0.0 2.8 2 1 0 2 2 2 0 Aspartyl protease APH PF01636.23 EEA22412.1 - 7.2e-08 32.6 0.0 1.2e-07 31.9 0.0 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA22412.1 - 0.015 14.9 0.4 0.32 10.6 0.0 2.6 1 1 2 3 3 3 0 Choline/ethanolamine kinase Rota_NSP3 PF01665.16 EEA22412.1 - 0.085 12.0 0.5 0.13 11.4 0.5 1.2 1 0 0 1 1 1 0 Rotavirus non-structural protein NSP3 TFA2_Winged_2 PF18121.1 EEA22412.1 - 0.13 12.0 0.1 0.35 10.6 0.1 1.7 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 VWA_2 PF13519.6 EEA22413.1 - 0.00026 21.6 0.0 0.001 19.7 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain ATP_bind_3 PF01171.20 EEA22413.1 - 0.068 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 PP-loop family LEF-4 PF05098.12 EEA22414.1 - 0.31 9.8 0.6 0.34 9.7 0.6 1.1 1 0 0 1 1 1 0 Late expression factor 4 (LEF-4) PLA2_B PF01735.18 EEA22415.1 - 7.5e-23 80.7 0.0 1.8e-22 79.4 0.0 1.5 1 1 0 1 1 1 1 Lysophospholipase catalytic domain 2_5_RNA_ligase2 PF13563.6 EEA22416.1 - 4.8e-33 114.2 0.4 1.2e-32 112.9 0.4 1.7 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.17 EEA22416.1 - 1.8e-27 95.9 0.0 4e-27 94.8 0.0 1.5 2 0 0 2 2 2 1 Poly(A) polymerase central domain MJ1316 PF04457.12 EEA22416.1 - 1e-19 71.0 1.2 2.9e-19 69.6 0.7 2.1 2 0 0 2 2 2 1 MJ1316 RNA cyclic group end recognition domain NTP_transf_2 PF01909.23 EEA22416.1 - 9e-06 25.9 0.0 5.4e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Nucleotidyltransferase domain Exo_endo_phos PF03372.23 EEA22416.1 - 1.1e-05 25.1 0.0 5.5e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LigT_PEase PF02834.16 EEA22416.1 - 2.3e-05 24.5 1.3 0.16 12.1 0.1 3.0 2 0 0 2 2 2 2 LigT like Phosphoesterase Nrap_D2 PF17403.2 EEA22416.1 - 0.044 13.5 0.0 0.17 11.7 0.0 1.9 1 1 0 1 1 1 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 EEA22416.1 - 0.077 13.1 0.2 1.1 9.4 0.0 2.8 3 0 0 3 3 3 0 Polymerase beta, Nucleotidyltransferase Exo_endo_phos_2 PF14529.6 EEA22416.1 - 0.091 12.6 0.4 3.3 7.6 0.0 3.5 4 0 0 4 4 4 0 Endonuclease-reverse transcriptase GMC_oxred_N PF00732.19 EEA22417.1 - 2.8e-42 145.1 0.0 3.9e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA22417.1 - 1.9e-35 122.5 0.0 3.4e-35 121.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EEA22417.1 - 2.6e-06 26.8 0.5 0.0011 18.2 1.7 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EEA22417.1 - 0.00013 21.7 0.0 0.00042 20.0 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA22417.1 - 0.00044 19.6 0.1 0.093 12.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA22417.1 - 0.00087 18.6 0.6 0.0016 17.8 0.3 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA22417.1 - 0.0011 19.2 0.2 0.0029 17.8 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA22417.1 - 0.0037 16.4 0.0 0.0058 15.7 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EEA22417.1 - 0.021 13.5 1.2 0.036 12.8 1.2 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 EEA22417.1 - 0.026 13.8 0.2 0.047 12.9 0.2 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_7 PF13241.6 EEA22417.1 - 0.057 13.9 0.0 0.25 11.8 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 EEA22417.1 - 0.098 11.5 0.1 0.14 11.0 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 EEA22417.1 - 0.13 11.4 0.9 0.21 10.8 0.9 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EEA22417.1 - 0.24 12.0 1.1 0.47 11.0 1.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA22417.1 - 0.64 9.3 2.6 1 8.6 2.6 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase LrgB PF04172.16 EEA22418.1 - 0.066 12.7 2.5 0.092 12.3 2.5 1.3 1 0 0 1 1 1 0 LrgB-like family ABC2_membrane_4 PF12730.7 EEA22418.1 - 4.9 7.1 13.2 7.3 6.5 0.7 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein Sod_Cu PF00080.20 EEA22419.1 - 2.6e-43 147.6 2.6 4.4e-43 146.9 2.6 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Sod_Cu PF00080.20 EEA22420.1 - 1.1e-41 142.3 2.9 2.1e-41 141.4 2.9 1.4 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) bZIP_1 PF00170.21 EEA22422.1 - 5.7e-06 26.3 6.5 8.7e-06 25.7 6.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor Cep57_CLD PF14073.6 EEA22422.1 - 0.0032 17.5 4.4 0.0047 17.0 4.4 1.2 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 ATG16 PF08614.11 EEA22422.1 - 0.0093 16.2 7.1 0.011 16.0 7.1 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) TMCO5 PF14992.6 EEA22422.1 - 0.018 14.6 2.3 0.021 14.4 2.3 1.1 1 0 0 1 1 1 0 TMCO5 family Fez1 PF06818.15 EEA22422.1 - 0.019 15.4 4.2 0.023 15.2 4.2 1.2 1 0 0 1 1 1 0 Fez1 Spore_GerAC PF05504.11 EEA22422.1 - 0.043 14.0 0.2 0.049 13.8 0.2 1.2 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal ANTH PF07651.16 EEA22422.1 - 0.044 12.8 2.6 0.058 12.4 2.6 1.1 1 0 0 1 1 1 0 ANTH domain APG6_N PF17675.1 EEA22422.1 - 0.061 13.9 7.0 0.076 13.5 7.0 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region FapA PF03961.13 EEA22422.1 - 0.12 10.9 0.6 0.13 10.8 0.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prominin PF05478.11 EEA22422.1 - 0.17 9.8 1.5 0.21 9.5 1.5 1.1 1 0 0 1 1 1 0 Prominin Fib_alpha PF08702.10 EEA22422.1 - 0.19 11.9 3.8 0.27 11.4 3.2 1.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ABC_tran_Xtn PF12848.7 EEA22422.1 - 0.35 10.9 6.7 0.63 10.1 6.7 1.4 1 1 0 1 1 1 0 ABC transporter HisKA PF00512.25 EEA22422.1 - 0.79 9.8 4.0 3 8.0 1.5 2.4 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF3425 PF11905.8 EEA22424.1 - 3.1e-17 62.7 0.0 7.6e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DUF3425 PF11905.8 EEA22425.1 - 3.1e-17 62.7 0.0 7.6e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) adh_short PF00106.25 EEA22426.1 - 3.6e-23 82.0 0.0 4.3e-16 59.0 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22426.1 - 1.5e-13 50.9 0.0 7e-11 42.1 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22426.1 - 3.2e-07 30.4 0.0 4.9e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA22426.1 - 9.9e-06 25.2 0.0 1.6e-05 24.5 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA22426.1 - 0.0012 18.1 0.0 0.0027 16.9 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein PRMT5 PF05185.16 EEA22426.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Glyco_hydro_18 PF00704.28 EEA22427.1 - 8.1e-71 239.3 0.4 9.2e-71 239.1 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Zn_clus PF00172.18 EEA22428.1 - 2.6e-08 33.8 11.3 5e-08 32.9 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA22428.1 - 1.6e-06 27.2 3.2 1.6e-06 27.2 3.2 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF2797 PF10977.8 EEA22428.1 - 0.92 9.3 5.4 2 8.3 5.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) CVNH PF08881.10 EEA22430.1 - 1.5e-16 60.9 0.5 2.4e-16 60.2 0.5 1.4 1 0 0 1 1 1 1 CVNH domain TPR_2 PF07719.17 EEA22431.1 - 3.1e-10 39.4 9.9 0.017 15.2 0.0 6.8 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EEA22431.1 - 1.5e-09 37.3 6.3 0.13 12.2 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 EEA22431.1 - 3.4e-08 33.9 5.1 0.0014 19.1 0.0 5.4 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA22431.1 - 1.2e-07 31.9 5.4 0.03 14.6 0.7 5.7 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA22431.1 - 9.1e-07 28.5 12.9 0.005 16.5 0.0 5.3 6 0 0 6 6 6 2 TPR repeat TPR_7 PF13176.6 EEA22431.1 - 5.5e-06 26.0 0.7 3.1 8.0 0.0 4.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA22431.1 - 5.8e-06 26.1 4.8 7.5 7.0 0.1 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA22431.1 - 7.2e-05 23.4 9.2 0.14 12.9 0.0 6.3 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_4 PF07721.14 EEA22431.1 - 0.00017 21.9 2.0 0.38 11.5 0.1 4.2 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA22431.1 - 0.0084 16.8 9.5 2.8 9.0 0.1 6.0 9 0 0 9 9 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA22431.1 - 0.0087 16.3 0.7 0.33 11.2 0.1 3.9 2 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EEA22431.1 - 0.01 16.1 6.8 2.6 8.6 0.0 5.1 7 0 0 7 7 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EEA22431.1 - 0.011 15.3 0.0 0.088 12.4 0.0 2.5 4 0 0 4 4 3 0 Bacterial type III secretion protein (HrpB1_HrpK) MIT PF04212.18 EEA22431.1 - 0.082 13.0 0.2 72 3.6 0.0 4.2 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 EEA22431.1 - 4.2 7.5 9.8 1.4 8.9 0.2 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Ribosomal_S30 PF04758.14 EEA22433.1 - 3.2e-28 97.7 7.3 3.5e-28 97.6 7.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Glyoxalase PF00903.25 EEA22434.1 - 7.7e-06 26.1 0.0 1.2e-05 25.5 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TauD PF02668.16 EEA22435.1 - 5.3e-61 206.8 0.3 6.5e-61 206.5 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family FMO-like PF00743.19 EEA22436.1 - 1.7e-39 135.7 0.0 3.5e-20 71.9 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA22436.1 - 1.5e-17 63.9 0.1 4.8e-12 45.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA22436.1 - 2.1e-14 53.5 0.0 8.2e-14 51.5 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA22436.1 - 2.1e-11 44.1 5.4 2.5e-06 27.3 0.9 3.5 3 1 1 4 4 4 3 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA22436.1 - 2.3e-08 34.1 0.2 6.4e-08 32.7 0.0 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EEA22436.1 - 3.3e-07 29.8 0.1 0.0019 17.4 0.0 3.1 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EEA22436.1 - 1.2e-06 28.6 3.1 5.2e-06 26.5 0.5 3.2 3 1 0 3 3 3 1 FAD-NAD(P)-binding ApbA PF02558.16 EEA22436.1 - 3e-06 26.9 0.0 0.0043 16.7 0.0 2.5 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EEA22436.1 - 1.4e-05 25.5 2.1 0.0002 21.9 0.4 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA22436.1 - 7.8e-05 22.1 0.1 0.00091 18.6 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Shikimate_DH PF01488.20 EEA22436.1 - 0.00021 21.4 0.9 0.02 15.0 0.1 2.8 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EEA22436.1 - 0.00032 19.5 1.5 0.00072 18.4 0.9 1.7 2 0 0 2 2 2 1 HI0933-like protein 3HCDH_N PF02737.18 EEA22436.1 - 0.0008 19.3 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EEA22436.1 - 0.0025 17.1 1.1 0.013 14.8 0.3 2.2 3 0 0 3 3 3 1 FAD binding domain NAD_binding_2 PF03446.15 EEA22436.1 - 0.0035 17.5 0.0 0.0096 16.1 0.0 1.7 2 0 0 2 2 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase FAD_binding_2 PF00890.24 EEA22436.1 - 0.0042 16.2 0.0 0.0082 15.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EEA22436.1 - 0.0047 16.2 0.5 0.031 13.5 0.3 2.1 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 EEA22436.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA22436.1 - 0.042 13.1 2.7 0.071 12.4 1.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EEA22436.1 - 0.063 12.3 1.6 0.12 11.5 1.6 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A F420_oxidored PF03807.17 EEA22436.1 - 0.074 13.6 0.1 9.5 6.9 0.0 2.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 EEA22436.1 - 0.18 11.4 0.1 0.38 10.3 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_Gly3P_dh_N PF01210.23 EEA22436.1 - 0.18 11.8 0.0 1.2 9.0 0.1 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_7 PF13241.6 EEA22436.1 - 0.22 12.0 2.2 2.6 8.5 0.0 3.0 3 1 0 3 3 3 0 Putative NAD(P)-binding MFS_1 PF07690.16 EEA22437.1 - 2.1e-35 122.3 23.2 7.3e-34 117.2 12.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EEA22437.1 - 3.8e-07 29.7 1.0 3.8e-07 29.7 1.0 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Myb_DNA-binding PF00249.31 EEA22438.1 - 7.2e-35 118.9 13.3 1.6e-13 50.6 0.3 3.3 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA22438.1 - 1.5e-26 92.4 4.3 8.3e-10 38.8 1.3 3.3 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA22438.1 - 1.2e-05 25.1 0.0 0.24 11.3 0.0 2.7 2 0 0 2 2 2 2 Myb DNA-binding like SANT_DAMP1_like PF16282.5 EEA22438.1 - 0.0028 17.8 0.4 0.24 11.6 0.0 3.0 2 1 1 3 3 3 1 SANT/Myb-like domain of DAMP1 HTH_Tnp_1 PF01527.20 EEA22438.1 - 0.14 12.5 0.4 19 5.6 0.0 2.9 3 0 0 3 3 3 0 Transposase NOA36 PF06524.12 EEA22438.1 - 0.14 11.4 5.5 0.26 10.6 5.5 1.4 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 EEA22438.1 - 0.18 11.4 4.9 0.28 10.7 4.9 1.3 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 EEA22438.1 - 3.1 5.8 6.3 4.3 5.3 6.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Transferase PF02458.15 EEA22439.1 - 1e-16 60.7 0.0 1.5e-14 53.5 0.0 2.4 2 1 0 2 2 2 2 Transferase family 3Beta_HSD PF01073.19 EEA22440.1 - 2.1e-23 82.7 0.0 2.8e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA22440.1 - 8.1e-21 74.6 0.0 1.1e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA22440.1 - 3.7e-12 46.3 0.0 2.2e-11 43.8 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EEA22440.1 - 1.4e-11 44.6 0.0 3.6e-11 43.3 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EEA22440.1 - 3.3e-10 39.6 0.0 4.3e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EEA22440.1 - 5.4e-08 32.7 0.0 9.9e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EEA22440.1 - 0.0008 18.9 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EEA22440.1 - 0.0017 17.6 0.0 0.0031 16.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EEA22440.1 - 0.064 13.2 0.1 0.15 11.9 0.1 1.6 1 1 0 1 1 1 0 KR domain adh_short PF00106.25 EEA22441.1 - 1.6e-40 138.6 0.0 2.1e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22441.1 - 2.3e-25 89.6 0.0 3e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22441.1 - 1.5e-08 34.7 0.0 2.3e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA22441.1 - 6.8e-05 22.8 0.0 0.00016 21.6 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EEA22441.1 - 0.00062 19.3 0.0 0.0012 18.3 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EEA22441.1 - 0.0019 18.5 0.0 0.0035 17.6 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EEA22441.1 - 0.01 16.0 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EEA22441.1 - 0.017 14.7 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EEA22441.1 - 0.03 14.9 0.1 0.076 13.6 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.17 EEA22441.1 - 0.035 13.2 0.0 0.045 12.9 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Shikimate_DH PF01488.20 EEA22441.1 - 0.061 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 EEA22441.1 - 0.18 11.1 0.0 0.37 10.1 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 EEA22441.1 - 0.19 11.0 0.1 0.28 10.5 0.1 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF1275 PF06912.11 EEA22442.1 - 2.6e-44 151.5 14.3 3.4e-44 151.1 14.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Ribosomal_L32e PF01655.18 EEA22442.1 - 0.012 16.1 0.0 0.018 15.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L32 DUF4131 PF13567.6 EEA22442.1 - 0.69 9.5 5.2 1.1 8.8 0.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Gln-synt_C PF00120.24 EEA22443.1 - 7e-66 222.6 0.0 8.5e-66 222.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EEA22443.1 - 0.14 11.9 0.2 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Glutamine synthetase, beta-Grasp domain DUF3431 PF11913.8 EEA22444.1 - 2.4e-70 236.7 0.1 2.8e-70 236.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) LigB PF02900.18 EEA22445.1 - 2.7e-34 118.5 0.0 3.3e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Fungal_trans_2 PF11951.8 EEA22446.1 - 1.4e-05 24.1 1.0 0.0034 16.3 0.0 2.3 2 1 0 2 2 2 2 Fungal specific transcription factor domain DUF5435 PF17503.2 EEA22446.1 - 0.031 14.0 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5435) NOA36 PF06524.12 EEA22447.1 - 4.7 6.4 14.7 5 6.3 14.7 1.0 1 0 0 1 1 1 0 NOA36 protein DUF3435 PF11917.8 EEA22448.1 - 5.9e-65 219.8 0.0 3.7e-64 217.2 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) GFO_IDH_MocA PF01408.22 EEA22449.1 - 3.9e-17 63.2 0.1 6.3e-17 62.5 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EEA22449.1 - 0.035 14.8 0.1 0.066 13.9 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 EEA22449.1 - 0.13 12.3 0.1 0.37 10.8 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain ABC_tran PF00005.27 EEA22450.1 - 3.4e-38 131.3 0.0 7.2e-18 65.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA22450.1 - 2.9e-37 128.8 22.3 1.2e-22 80.9 9.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA22450.1 - 2.4e-10 40.2 0.1 0.0016 17.9 0.0 3.4 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA22450.1 - 2.6e-08 34.1 1.2 0.33 10.7 0.8 3.7 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EEA22450.1 - 1e-07 32.3 0.6 0.039 14.2 0.0 3.8 3 1 0 3 3 3 2 AAA domain T2SSE PF00437.20 EEA22450.1 - 4.7e-07 29.1 0.1 0.0008 18.6 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 EEA22450.1 - 9.2e-06 26.1 1.3 0.23 11.8 0.6 3.3 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EEA22450.1 - 0.0001 22.0 0.5 0.011 15.4 0.2 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EEA22450.1 - 0.00022 20.8 0.1 0.36 10.4 0.1 2.7 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EEA22450.1 - 0.00036 20.5 1.1 0.91 9.4 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 EEA22450.1 - 0.00074 19.7 0.2 1.2 9.4 0.0 3.2 3 1 0 3 3 2 1 Putative exonuclease SbcCD, C subunit DnaB_C PF03796.15 EEA22450.1 - 0.0018 17.7 0.1 0.18 11.1 0.0 2.4 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_7 PF12775.7 EEA22450.1 - 0.0018 17.8 0.4 0.33 10.4 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region cobW PF02492.19 EEA22450.1 - 0.0018 17.9 0.7 0.34 10.5 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 EEA22450.1 - 0.002 17.5 1.2 0.043 13.2 0.2 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family NACHT PF05729.12 EEA22450.1 - 0.0021 18.0 4.2 0.35 10.8 0.0 3.1 3 0 0 3 3 2 2 NACHT domain CbiA PF01656.23 EEA22450.1 - 0.0022 18.0 0.3 0.35 10.9 0.0 3.3 3 0 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain DEAD PF00270.29 EEA22450.1 - 0.0025 17.6 0.1 2.4 7.9 0.0 2.9 3 0 0 3 3 2 1 DEAD/DEAH box helicase AAA_33 PF13671.6 EEA22450.1 - 0.0028 17.8 0.0 1.9 8.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EEA22450.1 - 0.0036 16.6 0.1 2.5 7.3 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA PF00004.29 EEA22450.1 - 0.0043 17.5 0.8 0.83 10.1 0.1 3.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EEA22450.1 - 0.0043 17.1 0.1 1.9 8.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF87 PF01935.17 EEA22450.1 - 0.0056 16.8 0.6 0.013 15.6 0.0 1.9 2 0 0 2 2 1 1 Helicase HerA, central domain Mg_chelatase PF01078.21 EEA22450.1 - 0.008 15.6 0.2 2.7 7.3 0.0 2.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.23 EEA22450.1 - 0.011 15.8 0.0 0.28 11.3 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EEA22450.1 - 0.025 15.1 0.2 2.3 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA22450.1 - 0.027 14.2 0.9 5.7 6.6 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein PhoH PF02562.16 EEA22450.1 - 0.027 13.9 0.5 0.74 9.2 0.1 2.8 3 0 0 3 3 3 0 PhoH-like protein TrwB_AAD_bind PF10412.9 EEA22450.1 - 0.04 12.8 1.2 0.28 10.0 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 EEA22450.1 - 0.045 13.8 0.5 4 7.4 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EEA22450.1 - 0.05 13.3 0.1 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2474 PF10617.9 EEA22450.1 - 0.055 13.3 2.1 0.055 13.3 0.1 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF2474) DUF2075 PF09848.9 EEA22450.1 - 0.063 12.5 0.3 9.6 5.3 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 EEA22450.1 - 0.13 12.2 3.8 1.1 9.3 0.2 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 EEA22450.1 - 0.14 12.1 0.0 5.1 6.9 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EEA22450.1 - 0.14 12.2 0.2 21 5.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain Septin PF00735.18 EEA22450.1 - 0.16 11.2 0.1 0.68 9.2 0.0 1.8 2 0 0 2 2 2 0 Septin NB-ARC PF00931.22 EEA22450.1 - 0.19 10.8 1.0 7.3 5.7 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain PduV-EutP PF10662.9 EEA22450.1 - 0.42 10.3 2.4 11 5.7 0.4 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.14 EEA22450.1 - 0.93 9.4 2.5 3.7 7.4 0.3 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Glyco_transf_25 PF01755.17 EEA22452.1 - 2.5e-05 24.3 0.0 0.0043 16.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) COesterase PF00135.28 EEA22454.1 - 6.9e-86 289.1 0.0 1e-85 288.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA22454.1 - 0.018 14.9 0.1 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA22454.1 - 0.18 11.2 0.1 0.3 10.5 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family MULE PF10551.9 EEA22455.1 - 2e-24 85.8 0.2 8.1e-23 80.7 0.2 2.6 2 0 0 2 2 2 1 MULE transposase domain zf-CCHC_6 PF15288.6 EEA22455.1 - 0.00062 19.6 0.7 0.0018 18.1 0.7 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-C2H2_10 PF16588.5 EEA22455.1 - 0.014 15.1 1.9 0.037 13.8 1.9 1.7 1 0 0 1 1 1 0 C2H2 zinc-finger Pkinase_Tyr PF07714.17 EEA22456.1 - 6.6e-17 61.6 0.0 1.6e-16 60.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EEA22456.1 - 2.8e-13 49.8 0.0 5.6e-13 48.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EEA22456.1 - 0.095 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family COX_ARM PF06481.14 EEA22456.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 COX Aromatic Rich Motif Aminotran_5 PF00266.19 EEA22459.1 - 3.2e-21 75.7 0.0 1.2e-11 44.3 0.0 2.5 2 1 0 2 2 2 2 Aminotransferase class-V zf_CopZ PF18423.1 EEA22459.1 - 0.12 12.3 0.0 0.5 10.4 0.0 2.0 2 0 0 2 2 2 0 Zinc binding domain SKG6 PF08693.10 EEA22461.1 - 7e-05 22.2 0.1 0.00013 21.3 0.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.12 EEA22461.1 - 0.18 11.7 1.3 0.43 10.4 1.3 1.6 1 1 0 1 1 1 0 Mid2 like cell wall stress sensor GPI-anchored PF10342.9 EEA22462.1 - 0.0016 19.2 2.6 0.002 18.9 1.9 1.5 1 1 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family FAD_binding_3 PF01494.19 EEA22463.1 - 2.7e-25 89.3 0.0 3.4e-18 66.0 0.0 2.9 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA22463.1 - 0.00051 20.2 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA22463.1 - 0.0006 20.3 0.0 0.19 12.3 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA22463.1 - 0.0028 16.9 0.0 0.064 12.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA22463.1 - 0.017 14.2 0.0 0.11 11.6 0.0 2.1 3 0 0 3 3 3 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EEA22463.1 - 0.021 13.9 0.0 0.048 12.7 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 EEA22463.1 - 0.032 13.8 0.0 0.057 13.0 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA22463.1 - 0.033 12.9 0.0 0.16 10.6 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 EEA22463.1 - 0.1 11.8 0.0 0.24 10.6 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EEA22463.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Pex14_N PF04695.13 EEA22464.1 - 0.6 10.8 4.8 0.24 12.0 1.4 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_L3 PF00297.22 EEA22465.1 - 3.8e-183 608.6 11.6 4.3e-183 608.4 11.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 NmrA PF05368.13 EEA22466.1 - 4.3e-59 199.9 0.3 5.5e-59 199.5 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA22466.1 - 1.7e-18 67.2 0.0 2.5e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA22466.1 - 7.7e-07 28.4 0.0 1.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA22466.1 - 0.0002 20.9 0.0 0.0003 20.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EEA22466.1 - 0.0036 17.5 0.1 0.0082 16.4 0.0 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain FtsJ PF01728.19 EEA22466.1 - 0.08 13.0 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 FtsJ-like methyltransferase Acetyltransf_10 PF13673.7 EEA22467.1 - 8.2e-13 48.4 0.0 3.1e-12 46.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA22467.1 - 2.2e-10 40.8 0.0 2.4e-09 37.5 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA22467.1 - 6.1e-10 39.4 0.0 2e-08 34.6 0.0 2.8 4 0 0 4 4 4 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA22467.1 - 0.00034 20.7 0.0 0.0016 18.5 0.0 2.1 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EEA22467.1 - 0.006 16.7 0.3 0.029 14.5 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA22467.1 - 0.0077 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein tRNA_anti-like PF12869.7 EEA22467.1 - 0.078 12.6 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 tRNA_anti-like NuiA PF07924.11 EEA22468.1 - 0.0032 17.9 1.5 0.13 12.7 0.4 3.0 2 1 0 2 2 2 1 Nuclease A inhibitor-like protein Smg4_UPF3 PF03467.15 EEA22468.1 - 0.012 15.6 0.2 0.018 15.0 0.2 1.2 1 0 0 1 1 1 0 Smg-4/UPF3 family Arginosuc_synth PF00764.19 EEA22469.1 - 5.7e-151 503.2 0.0 6.5e-151 503.0 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase tRNA_Me_trans PF03054.16 EEA22469.1 - 0.0036 16.1 0.0 0.0053 15.6 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 EEA22469.1 - 0.0083 15.6 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Methyltransf_25 PF13649.6 EEA22470.1 - 1.3e-15 57.9 0.0 3.4e-15 56.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA22470.1 - 3.5e-13 49.6 0.0 5e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA22470.1 - 1.8e-11 44.6 0.0 3.7e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA22470.1 - 5.5e-11 42.6 0.0 7.1e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA22470.1 - 1.4e-10 41.7 0.0 2.9e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA22470.1 - 4.3e-05 23.1 0.0 6.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EEA22470.1 - 0.00029 21.0 0.0 0.00051 20.2 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 EEA22470.1 - 0.00066 19.7 0.0 0.00097 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EEA22470.1 - 0.0014 18.0 0.0 0.0024 17.2 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain DUF4817 PF16087.5 EEA22470.1 - 0.0085 15.9 0.0 0.04 13.7 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain (DUF4817) CheR PF01739.18 EEA22470.1 - 0.021 14.3 0.0 1.2 8.6 0.0 2.3 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain TehB PF03848.14 EEA22470.1 - 0.063 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_5 PF01795.19 EEA22470.1 - 0.065 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 MraW methylase family Sugar_tr PF00083.24 EEA22471.1 - 1.2e-95 321.1 25.5 3.2e-94 316.4 25.5 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA22471.1 - 2.3e-19 69.5 37.9 1.3e-09 37.5 17.2 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_3 PF05977.13 EEA22471.1 - 0.76 8.1 6.8 0.056 11.8 1.6 1.6 2 0 0 2 2 2 0 Transmembrane secretion effector DUF3792 PF12670.7 EEA22471.1 - 2.4 8.3 22.1 1.1 9.5 6.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) NmrA PF05368.13 EEA22472.1 - 6.7e-34 117.5 0.0 9e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA22472.1 - 1.7e-15 57.4 0.0 3.2e-15 56.5 0.0 1.4 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EEA22472.1 - 1.4e-07 31.2 0.3 4.5e-07 29.6 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA22472.1 - 7.2e-05 22.3 0.1 0.00013 21.5 0.1 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EEA22472.1 - 0.016 14.6 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase F420_oxidored PF03807.17 EEA22472.1 - 0.1 13.2 0.1 0.47 11.1 0.1 2.0 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Zn_clus PF00172.18 EEA22473.1 - 3.4e-07 30.3 7.3 5.9e-07 29.5 7.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_primase_S PF01896.19 EEA22474.1 - 0.014 15.5 0.1 0.061 13.4 0.1 2.2 2 1 0 2 2 2 0 DNA primase small subunit RVT_2 PF07727.14 EEA22476.1 - 8.6e-38 130.3 0.3 8.6e-38 130.3 0.3 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EEA22476.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA22476.1 - 0.032 14.1 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Nsp1_C PF05064.13 EEA22477.1 - 0.29 10.9 5.9 0.37 10.6 0.3 2.4 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF1989 PF09347.10 EEA22478.1 - 2.2e-51 173.8 0.0 9.2e-51 171.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1989) Polysacc_deac_1 PF01522.21 EEA22478.1 - 3.2e-16 59.4 0.0 6.3e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EEA22478.1 - 6.5e-07 29.2 0.1 1.1e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 EEA22478.1 - 0.082 11.2 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) FAD_binding_3 PF01494.19 EEA22479.1 - 5.1e-62 210.2 0.0 6.2e-62 209.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA22479.1 - 1.2e-08 34.9 0.1 1.3e-07 31.6 0.0 2.3 2 1 0 3 3 3 1 FAD dependent oxidoreductase Phe_hydrox_dim PF07976.12 EEA22479.1 - 1.4e-07 31.7 0.0 6.8e-06 26.2 0.0 2.7 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_2 PF00890.24 EEA22479.1 - 7.4e-06 25.3 0.1 1.9e-05 23.9 0.0 1.6 2 1 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EEA22479.1 - 4.1e-05 22.9 0.0 7.7e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EEA22479.1 - 0.00011 21.0 0.0 0.00021 20.1 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EEA22479.1 - 0.0002 20.7 0.1 0.0021 17.3 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA22479.1 - 0.0002 21.5 0.1 0.00073 19.7 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EEA22479.1 - 0.00021 20.8 0.1 0.00031 20.2 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA22479.1 - 0.0011 18.4 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EEA22479.1 - 0.0011 17.9 0.0 0.0045 15.9 0.0 1.8 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.12 EEA22479.1 - 0.0014 17.8 0.0 0.002 17.3 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 EEA22479.1 - 0.0086 16.6 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA22479.1 - 0.014 14.5 0.0 0.025 13.7 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EEA22479.1 - 0.097 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 EEA22479.1 - 0.18 11.7 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Fungal_trans PF04082.18 EEA22480.1 - 6e-15 55.0 3.6 9.2e-15 54.4 3.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Duffy_binding PF05424.11 EEA22480.1 - 0.021 14.9 0.3 0.042 13.9 0.3 1.4 1 0 0 1 1 1 0 Duffy binding domain p450 PF00067.22 EEA22481.1 - 2e-64 218.1 0.0 2.6e-64 217.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3176 PF11374.8 EEA22482.1 - 1.4e-32 112.0 2.3 3.2e-32 110.9 2.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) Orthoreo_P10 PF07204.11 EEA22482.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 HKR_ArcB_TM PF18415.1 EEA22482.1 - 0.15 12.8 3.2 1.2 10.0 0.1 2.8 2 0 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain ETF PF01012.21 EEA22484.1 - 4.4e-43 147.3 2.9 8.2e-43 146.4 2.9 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EEA22484.1 - 1.4e-33 114.7 1.5 1.7e-33 114.5 0.3 1.8 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain Orn_Arg_deC_N PF02784.16 EEA22484.1 - 0.016 14.6 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Ribosomal_L1 PF00687.21 EEA22485.1 - 3.9e-63 212.9 4.5 6.2e-63 212.2 4.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SUN PF03856.13 EEA22486.1 - 9.8e-85 283.9 10.5 1.4e-84 283.4 10.5 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) RHSP PF07999.11 EEA22486.1 - 0.083 11.7 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Retrotransposon hot spot protein Dicty_CAD PF05720.12 EEA22487.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Cell-cell adhesion domain MIF4G PF02854.19 EEA22488.1 - 3.2e-59 200.1 0.4 5e-35 121.1 0.1 3.2 2 1 1 3 3 3 2 MIF4G domain Upf2 PF04050.14 EEA22488.1 - 3.4e-40 137.9 11.0 3.4e-40 137.9 11.0 2.8 4 0 0 4 4 4 1 Up-frameshift suppressor 2 CHCH PF06747.13 EEA22489.1 - 1.1e-06 28.6 4.5 1.9e-06 27.8 4.5 1.4 1 0 0 1 1 1 1 CHCH domain Cytotoxic PF09000.10 EEA22489.1 - 0.064 13.6 0.1 0.22 11.9 0.1 1.9 1 0 0 1 1 1 0 Cytotoxic GCK PF07802.11 EEA22489.1 - 0.085 13.3 2.2 0.19 12.2 2.2 1.6 1 0 0 1 1 1 0 GCK domain DUF334 PF03904.13 EEA22489.1 - 1.3 8.5 4.3 1.8 8.0 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Septin PF00735.18 EEA22490.1 - 1.7e-121 404.8 0.1 1.7e-121 404.8 0.1 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EEA22490.1 - 6.5e-09 35.9 0.6 1.4e-08 34.9 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA22490.1 - 0.0001 21.9 2.0 0.0069 15.9 0.0 3.0 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EEA22490.1 - 0.00067 20.2 3.1 0.013 16.0 0.0 2.7 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 EEA22490.1 - 0.0014 18.5 0.8 0.0014 18.5 0.8 3.3 3 1 0 3 3 2 1 RsgA GTPase Roc PF08477.13 EEA22490.1 - 0.0017 18.6 0.0 0.0037 17.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EEA22490.1 - 0.0032 17.9 0.1 0.011 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EEA22490.1 - 0.0041 17.4 0.6 0.019 15.3 0.0 2.4 2 2 0 2 2 2 1 AAA domain AIG1 PF04548.16 EEA22490.1 - 0.0048 16.2 3.1 0.0058 16.0 0.0 2.3 2 0 0 2 2 2 1 AIG1 family AAA_29 PF13555.6 EEA22490.1 - 0.0092 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Ras PF00071.22 EEA22490.1 - 0.025 14.2 0.0 0.094 12.3 0.0 2.0 1 0 0 1 1 1 0 Ras family Exonuc_VII_L PF02601.15 EEA22490.1 - 0.032 13.8 4.7 0.053 13.1 4.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Dynamin_N PF00350.23 EEA22490.1 - 0.036 14.1 6.7 0.43 10.6 0.0 3.5 3 1 0 3 3 2 0 Dynamin family AAA_24 PF13479.6 EEA22490.1 - 0.042 13.6 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EEA22490.1 - 0.071 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IIGP PF05049.13 EEA22490.1 - 0.078 12.0 0.2 0.078 12.0 0.2 2.2 2 1 1 3 3 3 0 Interferon-inducible GTPase (IIGP) RNA_helicase PF00910.22 EEA22490.1 - 0.14 12.5 0.5 0.84 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA helicase ATP_bind_1 PF03029.17 EEA22490.1 - 0.52 10.0 4.6 2.9 7.6 0.0 3.0 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Atg14 PF10186.9 EEA22490.1 - 2.6 7.0 10.3 3.9 6.5 10.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 EEA22490.1 - 5.6 4.8 5.9 8.3 4.2 5.9 1.1 1 0 0 1 1 1 0 Prominin DUF2937 PF11157.8 EEA22490.1 - 5.8 6.6 7.0 1.7 8.3 3.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) UPF0121 PF03661.13 EEA22491.1 - 5e-33 114.5 4.2 6.8e-33 114.1 4.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Mito_carr PF00153.27 EEA22492.1 - 2.9e-60 200.2 2.9 9.1e-19 67.2 1.2 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein SPX PF03105.19 EEA22492.1 - 0.03 14.3 0.4 0.03 14.3 0.4 1.9 2 0 0 2 2 2 0 SPX domain TPK_catalytic PF04263.16 EEA22494.1 - 1.3e-27 96.2 0.0 8.8e-27 93.5 0.0 2.3 1 1 1 2 2 2 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EEA22494.1 - 2.8e-17 62.2 0.0 4.5e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TPK_catalytic PF04263.16 EEA22495.1 - 5.6e-22 78.0 0.0 5.4e-21 74.9 0.0 2.5 1 1 1 2 2 2 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EEA22495.1 - 2e-17 62.7 0.0 3.1e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Mito_carr PF00153.27 EEA22496.1 - 2.6e-42 142.7 0.6 1.8e-13 50.2 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1179 PF06678.11 EEA22496.1 - 0.073 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) MRC1 PF09444.10 EEA22497.1 - 0.0056 17.2 0.2 0.0056 17.2 0.2 2.0 2 0 0 2 2 2 1 MRC1-like domain C1_2 PF03107.16 EEA22497.1 - 0.87 10.0 0.0 0.87 10.0 0.0 3.7 4 0 0 4 4 4 0 C1 domain CHDCT2 PF08074.11 EEA22498.1 - 0.025 14.7 0.0 0.063 13.5 0.0 1.7 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain CBM_21 PF03370.13 EEA22499.1 - 2.5e-36 124.2 0.8 4.3e-36 123.5 0.8 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EEA22499.1 - 3.6e-09 37.1 0.9 7.1e-09 36.1 0.9 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Complex1_49kDa PF00346.19 EEA22499.1 - 0.2 10.7 0.0 0.35 9.9 0.0 1.3 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit CBM_21 PF03370.13 EEA22500.1 - 2.4e-36 124.3 0.8 4.1e-36 123.6 0.8 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EEA22500.1 - 3.5e-09 37.1 0.9 6.8e-09 36.2 0.9 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Complex1_49kDa PF00346.19 EEA22500.1 - 0.19 10.8 0.0 0.34 10.0 0.0 1.3 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit CENP-T_C PF15511.6 EEA22501.1 - 4.4e-09 36.4 0.1 5.3e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EEA22501.1 - 1.9e-05 25.1 0.2 2.2e-05 24.8 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EEA22501.1 - 5e-05 23.4 0.2 7.3e-05 22.9 0.2 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EEA22501.1 - 0.00012 22.3 0.1 0.00021 21.5 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EEA22501.1 - 0.00017 21.9 0.1 0.00023 21.5 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EEA22501.1 - 0.0038 17.3 0.0 0.0045 17.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EEA22501.1 - 0.0045 17.0 0.0 0.0054 16.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated UPF0137 PF03677.13 EEA22501.1 - 0.05 13.4 0.2 0.061 13.1 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) TFIID_20kDa PF03847.13 EEA22501.1 - 0.059 13.9 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A HIGH_NTase1_ass PF16581.5 EEA22501.1 - 0.073 13.1 0.0 0.082 12.9 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region PGAP1 PF07819.13 EEA22503.1 - 9.6e-89 297.1 0.0 1.5e-88 296.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EEA22503.1 - 1.9e-05 25.4 0.2 1.9e-05 25.4 0.2 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EEA22503.1 - 0.00021 21.2 0.0 0.00035 20.5 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EEA22503.1 - 0.0015 18.2 3.0 0.0029 17.3 0.2 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA22503.1 - 0.0038 16.5 0.0 0.0075 15.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LCAT PF02450.15 EEA22503.1 - 0.0054 16.0 0.0 0.0098 15.1 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EEA22503.1 - 0.022 14.3 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 EEA22503.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA22504.1 - 9.6e-89 297.1 0.0 1.5e-88 296.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EEA22504.1 - 1.9e-05 25.4 0.2 1.9e-05 25.4 0.2 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EEA22504.1 - 0.00021 21.2 0.0 0.00035 20.5 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EEA22504.1 - 0.0015 18.2 3.0 0.0029 17.3 0.2 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA22504.1 - 0.0038 16.5 0.0 0.0075 15.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LCAT PF02450.15 EEA22504.1 - 0.0054 16.0 0.0 0.0098 15.1 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EEA22504.1 - 0.022 14.3 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 EEA22504.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold ABC_tran PF00005.27 EEA22506.1 - 1.7e-47 161.4 0.5 9.4e-24 84.5 0.1 3.9 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 EEA22506.1 - 5.5e-29 100.1 0.5 5.5e-29 100.1 0.5 2.2 2 0 0 2 2 1 1 Four helical bundle domain SMC_N PF02463.19 EEA22506.1 - 1.1e-16 60.9 0.0 5.8e-06 25.9 0.0 3.6 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA22506.1 - 3.5e-15 56.6 1.0 0.0022 17.9 0.0 4.8 5 0 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA22506.1 - 6.1e-09 35.5 0.1 0.0041 16.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA22506.1 - 7.7e-09 36.3 5.9 0.00021 21.9 0.1 3.2 4 0 0 4 4 2 2 AAA domain RsgA_GTPase PF03193.16 EEA22506.1 - 2.2e-07 31.0 0.0 0.0017 18.2 0.0 3.0 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EEA22506.1 - 1.1e-06 28.7 0.0 0.0064 16.6 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 EEA22506.1 - 1.7e-06 28.4 0.0 0.035 14.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EEA22506.1 - 4e-06 27.3 0.3 0.18 12.2 0.0 3.8 5 0 0 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 EEA22506.1 - 5e-06 26.8 0.0 0.068 13.4 0.0 3.4 4 0 0 4 4 2 2 AAA domain AAA_18 PF13238.6 EEA22506.1 - 7.2e-06 26.6 0.1 0.23 12.0 0.0 3.4 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EEA22506.1 - 1.8e-05 25.2 0.0 0.61 10.5 0.1 4.5 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EEA22506.1 - 4e-05 23.8 0.4 0.17 11.9 0.0 3.4 3 0 0 3 3 2 2 Helicase HerA, central domain PduV-EutP PF10662.9 EEA22506.1 - 4.6e-05 23.2 0.0 0.062 13.0 0.0 2.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EEA22506.1 - 7.3e-05 22.9 0.1 0.0086 16.2 0.0 3.2 3 0 0 3 3 2 1 Dynamin family AAA_15 PF13175.6 EEA22506.1 - 8.4e-05 22.4 1.2 0.37 10.5 0.1 3.1 2 2 1 3 3 3 2 AAA ATPase domain AAA_27 PF13514.6 EEA22506.1 - 0.00014 21.5 0.0 0.11 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EEA22506.1 - 0.00026 21.0 0.0 0.17 11.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EEA22506.1 - 0.00026 21.3 0.0 0.96 9.9 0.0 2.8 2 0 0 2 2 2 2 RNA helicase G-alpha PF00503.20 EEA22506.1 - 0.00027 20.2 0.1 1.4 8.0 0.0 3.2 3 0 0 3 3 3 2 G-protein alpha subunit MeaB PF03308.16 EEA22506.1 - 0.00028 19.9 0.1 0.71 8.8 0.0 2.7 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EEA22506.1 - 0.00053 20.2 0.0 0.98 9.6 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EEA22506.1 - 0.0014 18.7 0.0 3.1 7.9 0.0 3.2 3 1 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EEA22506.1 - 0.0014 18.4 0.0 2.3 7.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EEA22506.1 - 0.0015 18.3 0.0 1.7 8.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EEA22506.1 - 0.0045 17.2 0.0 1.4 9.2 0.0 3.1 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit HEAT_2 PF13646.6 EEA22506.1 - 0.0067 16.8 0.2 5.5 7.5 0.4 3.2 1 1 1 2 2 2 0 HEAT repeats ATP_bind_1 PF03029.17 EEA22506.1 - 0.0093 15.8 0.1 4.9 6.8 0.0 2.7 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein Roc PF08477.13 EEA22506.1 - 0.01 16.1 0.0 7.3 6.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 EEA22506.1 - 0.011 15.4 0.1 9.5 5.8 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain CLP1_P PF16575.5 EEA22506.1 - 0.011 15.5 0.0 1.1 9.0 0.0 3.2 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NB-ARC PF00931.22 EEA22506.1 - 0.012 14.8 0.1 0.42 9.7 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain HEAT PF02985.22 EEA22506.1 - 0.013 15.7 0.0 17 6.0 0.0 3.3 2 0 0 2 2 2 0 HEAT repeat MukB PF04310.12 EEA22506.1 - 0.015 15.1 0.1 2.4 7.9 0.0 2.3 2 0 0 2 2 2 0 MukB N-terminal AAA_7 PF12775.7 EEA22506.1 - 0.024 14.1 0.0 4 6.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EEA22506.1 - 0.026 14.3 0.0 12 5.6 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Rad17 PF03215.15 EEA22506.1 - 0.027 14.4 0.0 2.4 8.0 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain Adaptin_N PF01602.20 EEA22506.1 - 0.033 12.7 0.2 1.2 7.6 0.0 2.6 1 1 1 2 2 2 0 Adaptin N terminal region Cytidylate_kin PF02224.18 EEA22506.1 - 0.048 13.4 0.0 8.6 6.0 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase AAA_25 PF13481.6 EEA22506.1 - 0.052 13.1 0.1 3.8 7.0 0.0 3.0 3 0 0 3 3 2 0 AAA domain ATPase_2 PF01637.18 EEA22506.1 - 0.067 13.1 2.2 2.6 7.9 0.0 3.1 4 0 0 4 4 2 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EEA22506.1 - 0.072 13.1 0.0 19 5.3 0.0 3.4 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EEA22506.1 - 0.077 12.4 0.3 5 6.5 0.0 3.1 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI Ploopntkinase3 PF18751.1 EEA22506.1 - 0.08 12.8 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_13 PF13166.6 EEA22506.1 - 0.087 11.4 4.6 1.7 7.2 0.0 3.1 3 1 1 4 4 4 0 AAA domain ATP-synt_ab PF00006.25 EEA22506.1 - 0.097 12.3 0.0 11 5.7 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 EEA22506.1 - 0.1 11.8 0.0 11 5.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sugar_tr PF00083.24 EEA22507.1 - 1.3e-42 146.2 21.0 3.2e-41 141.7 21.0 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA22507.1 - 5.2e-31 107.9 47.2 4.8e-27 94.8 31.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA22507.1 - 0.052 12.0 0.2 0.052 12.0 0.2 2.1 2 1 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EEA22509.1 - 6.6e-43 147.0 34.9 6.6e-43 147.0 34.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA22509.1 - 1.8e-12 46.8 10.4 1.8e-12 46.8 10.4 2.2 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EEA22509.1 - 0.22 9.8 17.0 0.4 8.9 7.8 3.2 2 2 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Fas_alpha_ACP PF18325.1 EEA22510.1 - 1.6e-66 223.6 0.0 3.2e-66 222.6 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 EEA22510.1 - 2.3e-28 99.3 0.1 6.8e-28 97.7 0.1 1.9 1 1 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 EEA22510.1 - 1.6e-22 80.3 0.3 4e-22 79.0 0.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EEA22510.1 - 5.4e-16 58.7 0.0 1.7e-15 57.1 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain betaPIX_CC PF16523.5 EEA22510.1 - 0.0027 17.5 0.0 0.0062 16.3 0.0 1.6 1 0 0 1 1 1 1 betaPIX coiled coil KR PF08659.10 EEA22510.1 - 0.0078 16.1 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EEA22510.1 - 0.0091 15.6 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Citrate_synt PF00285.21 EEA22511.1 - 4.2e-99 332.0 0.0 5.6e-99 331.6 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF1729 PF08354.10 EEA22512.1 - 1.7e-145 484.4 0.0 2.6e-145 483.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EEA22512.1 - 1.1e-51 176.2 0.0 1.1e-50 173.0 0.0 2.2 2 0 0 2 2 2 1 Acyl transferase domain FAS_meander PF17951.1 EEA22512.1 - 6.4e-34 116.9 0.0 1.5e-33 115.7 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 EEA22512.1 - 2.9e-28 99.2 0.0 5.8e-28 98.2 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 EEA22512.1 - 3.4e-24 84.8 0.0 7.6e-24 83.6 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 EEA22512.1 - 1.4e-07 31.6 0.2 3.8e-07 30.1 0.2 1.7 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 EEA22512.1 - 5e-06 26.7 0.0 2.6e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Zn_clus PF00172.18 EEA22513.1 - 3.4e-10 39.9 9.8 7.3e-10 38.8 9.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA22513.1 - 0.00031 19.9 2.0 0.00031 19.9 2.0 1.8 1 1 1 2 2 2 1 Fungal specific transcription factor domain RTA1 PF04479.13 EEA22514.1 - 9.1e-68 227.9 12.7 1.2e-67 227.5 12.7 1.1 1 0 0 1 1 1 1 RTA1 like protein PAP2 PF01569.21 EEA22515.1 - 4.1e-25 88.1 0.2 4.1e-25 88.1 0.2 2.4 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EEA22515.1 - 0.02 14.6 5.2 0.091 12.4 0.1 2.7 3 1 0 3 3 3 0 PAP2 superfamily Cation_efflux PF01545.21 EEA22515.1 - 0.44 10.2 3.8 1.5 8.5 0.8 2.6 2 1 0 2 2 2 0 Cation efflux family Sulfotransfer_4 PF17784.1 EEA22516.1 - 2.9e-13 50.2 0.5 5.9e-10 39.3 0.0 2.8 2 1 1 3 3 3 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EEA22516.1 - 0.021 15.2 0.0 0.033 14.6 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase family Glyco_trans_2_3 PF13632.6 EEA22517.1 - 7.6e-43 146.7 3.6 2.4e-42 145.1 3.6 1.9 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Wzz PF02706.15 EEA22517.1 - 0.16 12.3 0.6 0.38 11.1 0.1 2.0 2 0 0 2 2 2 0 Chain length determinant protein ABC2_membrane_3 PF12698.7 EEA22517.1 - 2.7 7.0 7.7 0.16 11.0 1.6 1.8 2 0 0 2 2 2 0 ABC-2 family transporter protein Zn_clus PF00172.18 EEA22518.1 - 1.1e-07 31.8 12.5 1.8e-07 31.2 12.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA22518.1 - 0.00015 20.7 0.1 0.00021 20.3 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain CDH-cyt PF16010.5 EEA22519.1 - 2.7e-20 72.8 0.1 4.4e-20 72.1 0.1 1.3 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 EEA22519.1 - 6.3e-08 32.9 10.1 6.3e-08 32.9 10.1 3.1 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 EEA22519.1 - 0.0037 17.0 5.9 0.0037 17.0 5.9 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF2427) NAD_binding_10 PF13460.6 EEA22520.1 - 5.8e-07 29.6 0.2 2.1e-06 27.8 0.2 2.0 1 1 0 1 1 1 1 NAD(P)H-binding HTH_24 PF13412.6 EEA22520.1 - 0.078 12.5 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding CinA PF02464.17 EEA22520.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Competence-damaged protein CcmH PF03918.14 EEA22520.1 - 0.17 11.1 0.0 0.34 10.2 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein AAA PF00004.29 EEA22521.1 - 6.5e-12 46.0 0.0 1.5e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA22521.1 - 1.8e-05 25.0 0.0 4.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EEA22521.1 - 0.00018 21.3 0.0 0.00039 20.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EEA22521.1 - 0.00029 21.0 0.1 0.0013 18.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA22521.1 - 0.0007 19.6 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EEA22521.1 - 0.00078 19.4 0.0 0.0025 17.8 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_14 PF13173.6 EEA22521.1 - 0.0029 17.6 0.0 0.0061 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA22521.1 - 0.0048 17.3 0.0 0.026 14.9 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain NTPase_1 PF03266.15 EEA22521.1 - 0.035 14.0 0.0 0.077 12.9 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.6 EEA22521.1 - 0.069 13.4 0.1 0.57 10.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.6 EEA22521.1 - 0.1 13.0 0.1 0.41 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain SWIRM PF04433.17 EEA22522.1 - 1.6e-32 111.7 0.1 3.8e-32 110.5 0.1 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EEA22522.1 - 6e-31 106.2 9.5 1.3e-30 105.2 9.5 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EEA22522.1 - 7.9e-09 35.6 0.1 2.8e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA22522.1 - 2.3e-06 27.8 0.2 7.1e-06 26.2 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EEA22522.1 - 0.067 13.4 0.4 0.19 11.9 0.4 1.8 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 EEA22522.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.7 3 0 0 3 3 3 0 Myb DNA-binding like ZZ PF00569.17 EEA22522.1 - 2.1 8.2 4.3 14 5.6 4.3 2.1 1 1 0 1 1 1 0 Zinc finger, ZZ type Myb_DNA-bind_7 PF15963.5 EEA22523.1 - 0.027 14.4 0.3 0.12 12.3 0.0 2.2 2 0 0 2 2 2 0 Myb DNA-binding like Phage_lysozyme2 PF18013.1 EEA22523.1 - 0.038 14.0 0.6 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 Phage tail lysozyme ResIII PF04851.15 EEA22524.1 - 5.4e-26 91.6 0.4 4e-25 88.8 0.0 2.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA22524.1 - 6.1e-16 58.7 0.0 5.4e-15 55.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA22524.1 - 6.5e-11 42.3 0.0 6e-10 39.2 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EEA22524.1 - 9.7e-05 22.1 0.1 0.00034 20.4 0.0 2.0 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 EEA22524.1 - 0.0049 16.1 0.0 0.012 14.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Complex1_LYR PF05347.15 EEA22525.1 - 0.0055 16.7 1.2 0.018 15.1 1.2 1.9 1 0 0 1 1 1 1 Complex 1 protein (LYR family) TAF1D PF15333.6 EEA22525.1 - 0.03 14.1 1.6 0.055 13.2 1.6 1.3 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D Ank_4 PF13637.6 EEA22526.1 - 1.9e-12 47.4 2.2 1.2e-09 38.5 0.2 4.0 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA22526.1 - 6e-06 26.8 0.1 0.052 14.2 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA22526.1 - 7.7e-05 22.8 1.0 0.0053 17.2 0.1 3.8 4 1 0 4 4 4 1 Ankyrin repeat KilA-N PF04383.13 EEA22526.1 - 0.00089 19.1 0.3 0.0054 16.6 0.3 2.2 1 1 0 1 1 1 1 KilA-N domain Ank_5 PF13857.6 EEA22526.1 - 0.0013 19.0 0.5 0.17 12.3 0.2 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Spc42p PF11544.8 EEA22526.1 - 0.1 12.6 4.6 6.1 6.9 0.1 2.7 2 0 0 2 2 2 0 Spindle pole body component Spc42p Baculo_PEP_C PF04513.12 EEA22526.1 - 0.21 11.6 0.6 0.89 9.6 0.1 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_17 PF13431.6 EEA22528.1 - 7.4e-08 32.3 0.2 0.00071 19.8 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA22528.1 - 7.6e-08 31.9 0.4 0.0077 15.9 0.0 2.7 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.28 EEA22528.1 - 6.4e-07 28.9 6.3 0.026 14.3 0.7 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EEA22528.1 - 3.1e-05 24.0 2.4 0.00088 19.4 0.4 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA22528.1 - 3.6e-05 24.2 6.9 0.017 15.6 0.5 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA22528.1 - 0.0002 21.3 15.0 0.12 12.5 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA22528.1 - 0.00061 19.8 4.9 1.8 9.0 1.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA22528.1 - 0.0013 19.3 17.5 0.03 15.0 0.2 4.2 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA22528.1 - 0.016 16.0 0.5 0.016 16.0 0.5 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EEA22528.1 - 0.064 13.3 4.0 2.5 8.3 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Fungal_trans PF04082.18 EEA22530.1 - 0.013 14.6 0.7 0.028 13.5 0.2 1.7 2 0 0 2 2 2 0 Fungal specific transcription factor domain Pribosyltran_N PF13793.6 EEA22531.1 - 3e-43 146.5 0.0 3.2e-41 139.9 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EEA22531.1 - 5.6e-35 121.0 0.2 3e-29 102.4 0.1 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EEA22531.1 - 1.1e-07 31.5 0.1 5.5e-05 22.7 0.1 2.4 2 0 0 2 2 2 2 Phosphoribosyl transferase domain Pribosyltran_N PF13793.6 EEA22532.1 - 3e-43 146.4 0.0 3.2e-41 139.9 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EEA22532.1 - 3.8e-32 111.8 0.2 2.2e-26 93.1 0.2 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EEA22532.1 - 1.1e-07 31.5 0.1 5.5e-05 22.7 0.1 2.4 2 0 0 2 2 2 2 Phosphoribosyl transferase domain NAD_binding_7 PF13241.6 EEA22533.1 - 2.7e-33 114.5 0.0 4.5e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EEA22533.1 - 1.3e-31 108.1 0.1 2e-31 107.4 0.1 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EEA22533.1 - 1.5e-14 53.1 0.1 1.5e-14 53.1 0.1 1.7 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.20 EEA22533.1 - 0.002 18.2 0.0 0.0032 17.5 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EEA22533.1 - 0.0023 18.2 0.1 0.0046 17.2 0.1 1.5 1 1 0 1 1 1 1 TrkA-N domain Pyr_redox_3 PF13738.6 EEA22533.1 - 0.0034 16.7 0.1 0.0048 16.2 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EEA22533.1 - 0.0085 15.4 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 EEA22533.1 - 0.03 13.7 2.2 0.11 11.8 0.1 2.3 2 1 1 3 3 3 0 ThiF family FBA_2 PF07735.17 EEA22533.1 - 0.048 13.8 0.0 0.086 13.0 0.0 1.4 1 0 0 1 1 1 0 F-box associated DUF5444 PF17519.2 EEA22533.1 - 0.053 13.5 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5444) LSDAT_prok PF18171.1 EEA22533.1 - 0.055 12.7 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote Sec7 PF01369.20 EEA22534.1 - 6.5e-72 241.1 0.4 2.3e-71 239.3 0.4 2.1 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EEA22534.1 - 1.5e-43 148.4 6.2 1.5e-43 148.4 6.2 3.1 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EEA22534.1 - 1.4e-33 114.6 11.7 1.5e-33 114.5 0.1 5.6 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) DCB PF16213.5 EEA22534.1 - 3.5e-17 62.6 1.9 3.7e-16 59.3 0.3 3.2 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 2-oxoacid_dh PF00198.23 EEA22535.1 - 2.6e-79 265.9 0.1 3.5e-79 265.5 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EEA22535.1 - 4.4e-17 61.7 2.4 8.8e-17 60.7 0.3 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 EEA22535.1 - 9.8e-13 48.2 0.3 9.8e-13 48.2 0.3 2.7 3 0 0 3 3 3 1 e3 binding domain SAPS PF04499.15 EEA22536.1 - 0.043 12.6 0.1 0.047 12.5 0.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CENP-O PF09496.10 EEA22536.1 - 0.067 13.2 0.2 0.083 12.9 0.2 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component PLDc_2 PF13091.6 EEA22537.1 - 1.2e-15 57.5 0.2 3.6e-06 26.9 0.0 3.5 3 0 0 3 3 3 3 PLD-like domain PLDc PF00614.22 EEA22537.1 - 7.6e-14 51.2 2.8 4.1e-08 33.1 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc PF00614.22 EEA22538.1 - 2e-14 53.1 2.5 3e-08 33.5 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EEA22538.1 - 2e-13 50.3 0.1 0.0012 18.8 0.0 3.5 3 0 0 3 3 3 3 PLD-like domain Methyltransf_10 PF05971.12 EEA22539.1 - 2.8e-63 214.0 0.0 3.8e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EEA22539.1 - 3.8e-05 23.3 0.0 6.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DUF5353 PF17304.2 EEA22540.1 - 1.1e-33 114.7 3.6 1.6e-33 114.3 3.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5353) TrbC PF04956.13 EEA22540.1 - 0.018 15.2 0.1 0.027 14.7 0.1 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family DUF4203 PF13886.6 EEA22540.1 - 0.034 13.8 0.0 0.043 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4203) AP3D1 PF06375.11 EEA22540.1 - 0.12 12.6 3.5 0.31 11.3 3.7 1.5 1 1 1 2 2 2 0 AP-3 complex subunit delta-1 V-SNARE_C PF12352.8 EEA22541.1 - 5.9e-13 48.9 1.2 1.3e-12 47.8 1.2 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EEA22541.1 - 0.0017 18.2 0.0 0.0037 17.1 0.0 1.6 1 0 0 1 1 1 1 Sec20 Sigma70_r4 PF04545.16 EEA22541.1 - 0.031 13.8 0.2 0.069 12.7 0.2 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 Ldh_1_C PF02866.18 EEA22542.1 - 5.6e-48 163.0 0.0 1.5e-47 161.6 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EEA22542.1 - 5.3e-45 153.0 0.1 1.9e-44 151.2 0.0 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EEA22542.1 - 0.0028 16.7 0.0 0.004 16.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EEA22542.1 - 0.012 14.9 0.0 0.14 11.5 0.0 2.5 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_4 PF02056.16 EEA22542.1 - 0.093 12.3 0.1 3.4 7.2 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase AAA PF00004.29 EEA22543.1 - 1.4e-16 61.1 0.0 4.3e-16 59.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA22543.1 - 0.00032 20.7 0.0 0.001 19.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA22543.1 - 0.0011 19.3 0.6 0.012 15.9 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA22543.1 - 0.0033 17.8 2.6 0.0094 16.3 0.1 2.9 3 1 0 3 3 3 1 AAA ATPase domain Macoilin PF09726.9 EEA22543.1 - 0.0096 14.5 30.8 0.015 13.9 30.8 1.3 1 0 0 1 1 1 1 Macoilin family AAA_30 PF13604.6 EEA22543.1 - 0.025 14.3 0.0 0.025 14.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EEA22543.1 - 0.031 14.6 0.0 0.1 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EEA22543.1 - 0.039 13.7 0.0 0.039 13.7 0.0 3.7 2 1 0 2 2 2 0 AAA domain Mem_trans PF03547.18 EEA22543.1 - 0.14 10.5 3.0 0.48 8.8 2.5 2.0 1 1 0 1 1 1 0 Membrane transport protein Fungal_trans PF04082.18 EEA22544.1 - 5.3e-09 35.5 0.1 1.4e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22544.1 - 6.5e-05 23.0 8.1 6.5e-05 23.0 8.1 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DDE_Tnp_IS66_C PF13817.6 EEA22544.1 - 0.28 11.4 1.9 0.71 10.1 0.2 2.5 3 0 0 3 3 3 0 IS66 C-terminal element zf-C6H2 PF15801.5 EEA22544.1 - 2.7 8.4 6.9 0.43 10.9 2.5 2.0 2 1 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding DIOX_N PF14226.6 EEA22545.1 - 1.2e-30 106.7 0.0 2e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA22545.1 - 2.6e-16 60.0 0.0 1e-15 58.0 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily OKR_DC_1_N PF03709.15 EEA22545.1 - 0.067 13.5 0.4 0.58 10.4 0.1 2.4 3 0 0 3 3 3 0 Orn/Lys/Arg decarboxylase, N-terminal domain GP40 PF11025.8 EEA22545.1 - 0.17 11.6 0.1 0.34 10.7 0.1 1.5 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium Transp_cyt_pur PF02133.15 EEA22546.1 - 6.8e-81 272.3 39.0 7.7e-81 272.1 39.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin HbrB PF08539.11 EEA22547.1 - 5.5e-50 169.7 1.6 6.9e-50 169.3 0.0 2.1 2 0 0 2 2 2 1 HbrB-like Leader_Thr PF08254.11 EEA22547.1 - 1.1 9.1 6.2 2.8 7.7 6.2 1.7 1 0 0 1 1 1 0 Threonine leader peptide Gon7 PF08738.10 EEA22548.1 - 5e-14 52.3 1.6 1.4e-13 50.8 0.1 1.9 1 1 1 2 2 2 1 Gon7 family Vps39_1 PF10366.9 EEA22549.1 - 4.1e-32 110.7 3.4 6.6e-31 106.8 0.0 3.8 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 EEA22549.1 - 2.7e-18 66.6 0.0 1e-17 64.6 0.0 1.8 1 1 0 1 1 1 1 CNH domain Clathrin PF00637.20 EEA22549.1 - 1.3e-06 28.3 5.5 1.3e-05 25.1 2.8 3.1 3 0 0 3 3 3 1 Region in Clathrin and VPS PPR PF01535.20 EEA22549.1 - 0.076 13.3 0.4 3.2 8.2 0.0 3.4 3 0 0 3 3 3 0 PPR repeat ERO1 PF04137.15 EEA22549.1 - 0.14 11.4 0.1 0.26 10.4 0.1 1.4 1 0 0 1 1 1 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) TPR_14 PF13428.6 EEA22549.1 - 0.36 11.8 1.8 24 6.1 0.3 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat 6PF2K PF01591.18 EEA22550.1 - 1.4e-77 260.0 0.1 1.8e-77 259.6 0.1 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EEA22550.1 - 6e-40 137.0 0.0 9.6e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.10 EEA22550.1 - 7.9e-05 22.2 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EEA22550.1 - 0.00012 22.3 0.0 0.00026 21.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 EEA22551.1 - 3.2e-77 258.8 0.1 4.5e-77 258.3 0.1 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EEA22551.1 - 6.1e-40 137.0 0.0 9.6e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.10 EEA22551.1 - 7.9e-05 22.2 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EEA22551.1 - 0.00012 22.3 0.0 0.00026 21.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EEA22551.1 - 0.14 11.4 0.0 7.1 5.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin 6PF2K PF01591.18 EEA22552.1 - 1.5e-64 217.4 0.2 2.1e-64 216.9 0.2 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EEA22552.1 - 5.9e-40 137.0 0.0 9.2e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RRM_1 PF00076.22 EEA22553.1 - 8.5e-22 76.8 0.1 1.1e-15 57.2 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA22553.1 - 0.0036 17.1 0.0 0.23 11.4 0.0 2.6 2 1 0 2 2 2 1 Occluded RNA-recognition motif Laminin_G_1 PF00054.23 EEA22553.1 - 0.098 12.9 0.0 0.91 9.7 0.0 2.1 2 0 0 2 2 2 0 Laminin G domain RRM_5 PF13893.6 EEA22553.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) His_Phos_1 PF00300.22 EEA22554.1 - 2e-27 96.1 0.0 3e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Sugar_tr PF00083.24 EEA22555.1 - 2.3e-91 306.9 28.2 2.8e-91 306.6 28.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA22555.1 - 7.6e-15 54.7 45.8 5.1e-13 48.7 17.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Synaptobrevin PF00957.21 EEA22556.1 - 0.13 12.1 1.1 0.18 11.6 1.1 1.1 1 0 0 1 1 1 0 Synaptobrevin BCDHK_Adom3 PF10436.9 EEA22557.1 - 1.1e-74 249.7 0.0 1.5e-74 249.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EEA22557.1 - 3.5e-13 50.0 0.0 6.9e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EEA22557.1 - 0.0057 16.5 0.0 0.014 15.2 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SKN1 PF03935.15 EEA22558.1 - 1.7e-225 749.2 0.9 2.1e-225 748.9 0.9 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Aminotran_4 PF01063.19 EEA22560.1 - 6.3e-14 52.4 0.0 8.8e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV TPR_1 PF00515.28 EEA22561.1 - 3.7e-50 165.8 29.2 5.4e-08 32.3 0.1 11.3 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 EEA22561.1 - 1.6e-45 149.5 20.9 1.9e-05 24.4 0.0 10.8 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 EEA22561.1 - 1.8e-36 121.3 19.1 6.8e-05 22.8 0.0 10.9 10 1 0 10 10 10 10 Tetratricopeptide repeat TPR_14 PF13428.6 EEA22561.1 - 1.6e-26 90.7 10.9 5.9e-05 23.5 0.1 8.9 4 3 5 9 9 9 8 Tetratricopeptide repeat TPR_17 PF13431.6 EEA22561.1 - 2.5e-26 90.1 15.1 0.00039 20.6 0.1 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 EEA22561.1 - 1.2e-25 88.9 28.3 3.4e-06 26.6 0.2 10.0 6 3 4 10 10 10 6 TPR repeat TPR_16 PF13432.6 EEA22561.1 - 3.4e-25 88.4 6.7 5.2e-05 23.8 0.1 6.6 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 EEA22561.1 - 1.2e-24 86.6 16.1 0.00011 22.7 0.1 7.4 4 2 3 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 EEA22561.1 - 1.9e-22 79.3 20.0 4.2e-05 23.7 0.9 7.8 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.6 EEA22561.1 - 7.5e-21 73.3 18.4 0.0017 18.9 0.0 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 EEA22561.1 - 2e-18 65.0 15.8 0.0094 15.9 0.1 9.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 EEA22561.1 - 3.6e-16 59.1 12.3 0.00063 19.8 0.5 7.0 2 2 6 8 8 8 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA22561.1 - 2.3e-13 50.2 12.6 2.1e-08 34.3 2.8 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EEA22561.1 - 2.2e-08 33.6 10.5 0.013 14.7 1.5 5.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 EEA22561.1 - 1.8e-06 27.8 5.8 0.019 14.7 0.0 4.1 3 2 0 4 4 3 3 Tetratricopeptide repeat-like domain BTAD PF03704.17 EEA22561.1 - 3.1e-06 27.7 6.7 0.01 16.2 0.1 3.4 3 0 0 3 3 3 2 Bacterial transcriptional activator domain TPR_MalT PF17874.1 EEA22561.1 - 0.0018 17.7 5.7 0.04 13.3 0.1 3.7 1 1 2 4 4 4 2 MalT-like TPR region DUF2225 PF09986.9 EEA22561.1 - 0.015 15.1 4.8 1.2 8.8 0.0 2.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 EEA22561.1 - 0.076 13.3 4.0 0.67 10.3 0.0 3.9 3 1 2 5 5 4 0 Tetratricopeptide repeat MIT PF04212.18 EEA22561.1 - 1.3 9.2 19.4 14 5.8 1.8 5.8 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain PAT1 PF09770.9 EEA22562.1 - 8.9 4.4 14.2 12 4.0 14.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GST_N PF02798.20 EEA22563.1 - 2.5e-09 37.4 0.0 4.5e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA22563.1 - 2.2e-05 24.8 0.0 3.7e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA22563.1 - 4.1e-05 23.8 0.0 9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA22563.1 - 0.014 15.5 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TetR_C_7 PF14246.6 EEA22563.1 - 0.085 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 AefR-like transcriptional repressor, C-terminal domain HsbA PF12296.8 EEA22564.1 - 1.2e-09 38.6 0.9 4.9e-09 36.6 0.1 2.0 2 0 0 2 2 2 1 Hydrophobic surface binding protein A ETRAMP PF09716.10 EEA22564.1 - 0.0044 17.1 0.0 0.019 15.0 0.0 2.1 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF1131 PF06572.12 EEA22564.1 - 0.076 12.7 0.1 0.093 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1131) DUF1380 PF07128.12 EEA22564.1 - 0.14 12.4 0.3 4.5 7.4 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1380) Gemini_C4 PF01492.17 EEA22565.1 - 0.0096 15.8 0.1 3.5 7.6 0.0 2.5 2 0 0 2 2 2 2 Geminivirus C4 protein NUC173 PF08161.12 EEA22568.1 - 1.4e-79 266.6 0.1 2e-77 259.4 0.1 3.5 3 0 0 3 3 3 1 NUC173 domain HEAT PF02985.22 EEA22568.1 - 0.00049 20.1 1.4 3.7 8.0 0.1 4.2 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 EEA22568.1 - 0.011 16.1 1.2 0.53 10.7 0.1 3.9 4 0 0 4 4 4 0 HEAT repeats LSM PF01423.22 EEA22569.1 - 1.4e-16 59.9 0.1 1.4e-16 59.9 0.1 1.6 2 0 0 2 2 2 1 LSM domain RecX PF02631.16 EEA22569.1 - 0.041 14.3 0.1 0.062 13.8 0.1 1.3 1 0 0 1 1 1 0 RecX family DUF4710 PF15828.5 EEA22569.1 - 0.25 11.5 3.4 0.4 10.8 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) SMN PF06003.12 EEA22569.1 - 0.9 8.7 3.8 17 4.5 2.2 2.0 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Glyco_transf_54 PF04666.13 EEA22572.1 - 9.8e-07 27.9 0.1 9e-05 21.5 0.1 2.8 2 1 0 2 2 2 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Ribonuclease_3 PF00636.26 EEA22574.1 - 1.5e-42 144.5 0.0 2.7e-22 79.4 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EEA22574.1 - 1.5e-24 86.6 0.2 3e-11 43.6 0.0 4.0 3 0 0 3 3 3 3 Ribonuclease-III-like DEAD PF00270.29 EEA22574.1 - 2.4e-22 79.5 0.0 6.3e-22 78.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Dicer_dimer PF03368.14 EEA22574.1 - 1.1e-19 70.4 0.1 2.4e-19 69.3 0.1 1.6 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.31 EEA22574.1 - 6.2e-19 68.4 0.1 1.5e-18 67.2 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA22574.1 - 6e-14 52.4 0.0 1.3e-13 51.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EEA22574.1 - 0.021 14.3 0.0 0.049 13.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Corona_NS1 PF06145.11 EEA22574.1 - 0.086 12.4 0.1 0.23 11.0 0.1 1.7 1 0 0 1 1 1 0 Coronavirus nonstructural protein NS1 Proteasome PF00227.26 EEA22575.1 - 5.4e-57 192.4 0.1 1.1e-32 113.1 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EEA22575.1 - 8.9e-11 41.3 0.1 3.1e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Proteasome PF00227.26 EEA22576.1 - 2.2e-41 141.4 0.1 5.3e-22 78.2 0.0 2.0 2 0 0 2 2 2 2 Proteasome subunit RINGv PF12906.7 EEA22577.1 - 4.9e-09 36.2 3.8 2.2e-08 34.1 0.9 2.3 2 0 0 2 2 2 1 RING-variant domain PHD_4 PF16866.5 EEA22577.1 - 0.013 15.5 5.9 0.77 9.9 1.5 2.4 2 0 0 2 2 2 0 PHD-finger zf-RING_2 PF13639.6 EEA22577.1 - 0.05 14.0 6.2 0.49 10.8 2.4 2.3 2 0 0 2 2 2 0 Ring finger domain Ima1_N PF09779.9 EEA22577.1 - 0.9 10.4 7.9 1 10.2 0.9 2.1 2 0 0 2 2 2 0 Ima1 N-terminal domain zf-RING_4 PF14570.6 EEA22577.1 - 6.2 6.7 8.3 19 5.2 6.5 2.3 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EEA22577.1 - 6.4 6.8 8.4 3.6 7.6 5.2 2.0 2 0 0 2 2 2 0 PHD-finger RINGv PF12906.7 EEA22578.1 - 3.3e-09 36.7 3.8 1.8e-08 34.4 0.9 2.3 2 0 0 2 2 2 1 RING-variant domain PHD_4 PF16866.5 EEA22578.1 - 0.0096 16.0 5.9 0.62 10.2 1.5 2.3 2 0 0 2 2 2 2 PHD-finger zf-RING_2 PF13639.6 EEA22578.1 - 0.035 14.5 6.2 0.39 11.1 2.4 2.3 2 0 0 2 2 2 0 Ring finger domain Ima1_N PF09779.9 EEA22578.1 - 0.61 10.9 7.9 0.8 10.6 0.9 2.1 2 0 0 2 2 2 0 Ima1 N-terminal domain zf-RING_4 PF14570.6 EEA22578.1 - 4.1 7.3 8.1 14 5.6 6.4 2.3 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EEA22578.1 - 4.7 7.2 8.4 2.9 7.9 5.2 2.0 2 0 0 2 2 2 0 PHD-finger Lyase_1 PF00206.20 EEA22580.1 - 6e-23 81.7 0.0 1.2e-22 80.8 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EEA22580.1 - 1.3e-17 64.1 0.1 7.8e-17 61.6 0.0 2.3 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus Exo70 PF03081.15 EEA22581.1 - 2.6e-83 280.1 0.0 6.8e-83 278.8 0.0 1.6 2 0 0 2 2 2 1 Exo70 exocyst complex subunit DUF448 PF04296.13 EEA22581.1 - 0.012 15.5 0.0 1.1 9.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF448) Bap31_Bap29_C PF18035.1 EEA22581.1 - 0.057 13.4 0.2 0.057 13.4 0.2 2.1 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Prominin PF05478.11 EEA22581.1 - 0.068 11.1 1.1 0.14 10.1 1.1 1.4 1 0 0 1 1 1 0 Prominin DUF4355 PF14265.6 EEA22581.1 - 0.083 13.1 1.7 0.46 10.7 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4355) MHB PF16525.5 EEA22581.1 - 0.2 11.9 0.3 17 5.8 0.0 3.5 2 1 1 3 3 3 0 Haemophore, haem-binding FliS PF02561.14 EEA22581.1 - 0.49 10.7 2.2 2.1 8.7 0.7 2.9 3 1 0 3 3 3 0 Flagellar protein FliS FadA PF09403.10 EEA22581.1 - 7.7 7.1 7.3 7.9 7.0 0.1 3.6 4 0 0 4 4 4 0 Adhesion protein FadA PLA2_B PF01735.18 EEA22582.1 - 8.7e-26 90.4 0.0 2e-25 89.2 0.0 1.6 1 1 0 1 1 1 1 Lysophospholipase catalytic domain DSPc PF00782.20 EEA22583.1 - 6.6e-10 38.9 0.0 1.3e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA22583.1 - 0.019 14.6 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EEA22583.1 - 0.029 14.3 0.0 0.083 12.8 0.0 1.7 2 0 0 2 2 2 0 Tyrosine phosphatase family PPR_2 PF13041.6 EEA22584.1 - 2.6e-13 50.0 0.0 0.012 15.7 0.0 5.1 4 1 1 5 5 5 4 PPR repeat family PPR_long PF17177.4 EEA22584.1 - 1.8e-09 37.3 0.1 0.014 14.8 0.0 3.6 3 2 0 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 EEA22584.1 - 8.7e-09 35.1 0.2 1.2 9.5 0.0 6.1 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 EEA22584.1 - 7e-08 32.4 0.7 0.27 11.3 0.0 5.8 6 1 1 7 7 7 2 Pentatricopeptide repeat domain PET122 PF05476.11 EEA22584.1 - 0.028 13.7 3.1 0.028 13.7 0.2 2.4 4 0 0 4 4 4 0 PET122 HEAT_2 PF13646.6 EEA22584.1 - 0.032 14.6 0.6 3.3 8.1 0.4 3.1 3 1 0 3 3 3 0 HEAT repeats TPR_14 PF13428.6 EEA22584.1 - 0.058 14.2 0.6 48 5.1 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat ECSIT PF06239.11 EEA22584.1 - 0.069 12.3 0.0 19 4.3 0.0 2.9 3 0 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway LSM PF01423.22 EEA22585.1 - 1.5e-17 63.0 0.0 2.2e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA22585.1 - 0.011 15.8 0.0 0.016 15.4 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain APH PF01636.23 EEA22586.1 - 0.016 15.2 0.2 0.058 13.3 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EEA22586.1 - 0.19 10.9 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase Hat1_N PF10394.9 EEA22587.1 - 9.9e-53 178.7 0.1 1.7e-52 177.9 0.1 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_10 PF13673.7 EEA22587.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA22587.1 - 0.11 12.9 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Retrotrans_gag PF03732.17 EEA22588.1 - 8.9e-06 25.9 0.0 2.8e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.5 EEA22588.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) p450 PF00067.22 EEA22589.1 - 5.1e-42 144.2 0.0 7.7e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF1204 PF06721.11 EEA22589.1 - 0.015 14.7 0.1 0.051 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1204) CyRPA PF18638.1 EEA22589.1 - 0.18 10.9 0.1 0.26 10.4 0.1 1.2 1 0 0 1 1 1 0 Cysteine-Rich Protective Antigen 6 bladed domain Zip PF02535.22 EEA22590.1 - 2.3e-34 119.1 16.4 4.5e-26 91.9 9.3 3.0 2 1 0 2 2 2 2 ZIP Zinc transporter SfLAP PF11139.8 EEA22590.1 - 0.036 13.5 6.2 0.029 13.8 1.7 2.3 3 0 0 3 3 3 0 Sap, sulfolipid-1-addressing protein WD40 PF00400.32 EEA22591.1 - 1.5e-39 133.3 22.5 2.7e-07 31.2 0.1 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.7 EEA22591.1 - 6.1e-12 45.3 0.2 1.2e-11 44.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EEA22591.1 - 7.4e-09 35.8 0.5 0.65 10.3 0.0 6.1 1 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA22591.1 - 7.6e-08 31.4 7.0 0.093 11.4 0.1 6.1 3 2 4 7 7 7 2 Nucleoporin Nup120/160 F-box PF00646.33 EEA22591.1 - 3e-05 23.8 0.4 6.4e-05 22.7 0.4 1.6 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EEA22591.1 - 0.00067 19.2 0.1 0.0012 18.4 0.1 1.4 1 0 0 1 1 1 1 F-box PQQ_2 PF13360.6 EEA22591.1 - 0.0024 17.5 2.4 0.02 14.5 0.9 2.5 1 1 1 2 2 2 1 PQQ-like domain PALB2_WD40 PF16756.5 EEA22591.1 - 0.0033 16.4 5.0 2.9 6.7 0.0 4.1 3 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 EEA22591.1 - 0.0037 16.6 0.0 0.21 10.8 0.0 2.6 1 1 2 3 3 3 1 WD40-like domain Zn_clus PF00172.18 EEA22592.1 - 4.5e-08 33.1 7.2 4.5e-08 33.1 7.2 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA22592.1 - 7.2e-06 25.1 0.2 1e-05 24.6 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mito_carr PF00153.27 EEA22593.1 - 3.1e-43 145.6 3.7 2.1e-14 53.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_fiss_reg PF05308.11 EEA22594.1 - 0.038 14.1 4.2 0.045 13.8 1.6 1.9 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF155 PF02582.14 EEA22595.1 - 8.3e-51 172.6 0.1 1.5e-50 171.7 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 EEA22595.1 - 0.094 13.2 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 U3_snoRNA_assoc PF08297.11 EEA22596.1 - 3.3e-12 46.9 1.2 3.3e-12 46.9 1.2 4.9 2 1 2 4 4 4 1 U3 snoRNA associated CTK3 PF12243.8 EEA22597.1 - 1.1e-49 167.6 0.5 1.5e-49 167.1 0.5 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EEA22597.1 - 2e-20 72.7 6.5 2e-20 72.7 6.5 1.8 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus DUF3873 PF12989.7 EEA22597.1 - 0.049 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) P5CR_dimer PF14748.6 EEA22598.1 - 3.1e-33 114.1 2.0 3.3e-33 114.0 1.0 1.6 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EEA22598.1 - 3.5e-10 40.3 0.1 1.3e-09 38.5 0.0 2.1 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Voltage_CLC PF00654.20 EEA22599.1 - 2.1e-89 300.2 28.3 2.1e-89 300.2 28.3 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EEA22599.1 - 0.00022 21.6 0.0 0.035 14.5 0.0 2.4 2 0 0 2 2 2 2 CBS domain Voltage_CLC PF00654.20 EEA22600.1 - 2.1e-89 300.2 28.3 2.1e-89 300.2 28.3 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EEA22600.1 - 0.00022 21.6 0.0 0.036 14.5 0.0 2.4 2 0 0 2 2 2 2 CBS domain AAA_5 PF07728.14 EEA22601.1 - 3.6e-127 419.0 0.0 3.7e-22 78.8 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EEA22601.1 - 2.1e-48 162.9 2.8 4.2e-17 62.3 0.0 5.4 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_7 PF12775.7 EEA22601.1 - 1.9e-30 105.7 2.5 2.2e-06 27.3 0.0 7.3 7 0 0 7 7 7 6 P-loop containing dynein motor region AAA_lid_5 PF17865.1 EEA22601.1 - 1.3e-29 102.3 0.4 1.8e-28 98.7 0.0 3.3 3 0 0 3 3 1 1 Midasin AAA lid domain AAA PF00004.29 EEA22601.1 - 2.8e-29 102.2 0.6 0.00029 21.3 0.0 7.5 7 0 0 7 7 6 6 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 EEA22601.1 - 1.8e-28 99.0 0.0 4.3e-11 42.8 0.0 7.1 7 0 0 7 7 6 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA22601.1 - 1.6e-27 97.0 9.0 4.9e-05 23.8 0.1 8.3 6 1 0 6 6 6 5 AAA ATPase domain Dynein_heavy PF03028.15 EEA22601.1 - 6.6e-22 77.8 0.0 5.1e-06 26.6 0.0 8.0 9 0 0 9 9 7 4 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 EEA22601.1 - 1.6e-19 70.1 0.0 0.06 12.3 0.0 8.2 9 0 0 9 9 8 4 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 EEA22601.1 - 5.3e-18 65.6 2.4 0.049 13.9 0.0 8.8 9 0 0 9 9 6 4 AAA domain AAA_33 PF13671.6 EEA22601.1 - 7.7e-17 61.8 0.1 0.0096 16.1 0.0 7.0 6 0 0 6 6 6 2 AAA domain Sigma54_activat PF00158.26 EEA22601.1 - 1.7e-16 60.4 0.0 0.027 14.2 0.0 6.0 6 0 0 6 6 5 4 Sigma-54 interaction domain AAA_14 PF13173.6 EEA22601.1 - 3.6e-16 59.4 0.0 0.0073 16.3 0.0 7.6 8 0 0 8 8 6 2 AAA domain AAA_18 PF13238.6 EEA22601.1 - 2.1e-14 54.2 0.1 0.13 12.8 0.0 7.5 6 0 0 6 6 6 2 AAA domain AAA_30 PF13604.6 EEA22601.1 - 3.8e-14 52.8 0.0 0.035 13.8 0.0 7.3 6 2 0 6 6 6 3 AAA domain TsaE PF02367.17 EEA22601.1 - 5.2e-14 52.3 1.2 0.1 12.6 0.0 6.6 6 0 0 6 6 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EEA22601.1 - 1.8e-13 51.2 2.2 0.1 13.1 0.0 6.8 6 0 0 6 6 6 3 ABC transporter RNA_helicase PF00910.22 EEA22601.1 - 1e-11 45.2 0.7 0.84 10.1 0.0 6.8 6 0 0 6 6 6 1 RNA helicase Sigma54_activ_2 PF14532.6 EEA22601.1 - 2e-11 44.2 0.3 0.00078 19.6 0.1 5.7 5 0 0 5 5 5 2 Sigma-54 interaction domain Mg_chelatase PF01078.21 EEA22601.1 - 3.4e-11 42.9 0.4 10 5.4 0.0 8.4 8 0 0 8 8 8 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EEA22601.1 - 6.5e-11 42.5 2.2 0.0059 16.5 0.0 6.2 6 0 0 6 6 6 1 Rad17 P-loop domain Zeta_toxin PF06414.12 EEA22601.1 - 7.7e-11 41.6 0.4 8.1 5.7 0.0 8.4 8 0 0 8 8 8 0 Zeta toxin SRP54 PF00448.22 EEA22601.1 - 1.5e-09 37.8 4.4 0.18 11.4 0.0 5.8 6 0 0 6 6 6 2 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EEA22601.1 - 1.6e-09 38.2 2.6 3.2 8.1 0.1 6.7 6 0 0 6 6 6 0 AAA domain NACHT PF05729.12 EEA22601.1 - 3.6e-09 36.7 6.7 0.041 13.8 0.0 6.3 7 0 0 7 7 5 2 NACHT domain RsgA_GTPase PF03193.16 EEA22601.1 - 4.7e-09 36.4 3.9 0.21 11.5 0.2 6.1 6 0 0 6 6 5 1 RsgA GTPase T2SSE PF00437.20 EEA22601.1 - 5.1e-09 35.6 3.2 0.0041 16.2 0.0 6.2 6 0 0 6 6 6 1 Type II/IV secretion system protein AAA_25 PF13481.6 EEA22601.1 - 1.2e-08 34.8 0.9 0.4 10.2 0.0 6.0 6 0 0 6 6 5 1 AAA domain ATPase_2 PF01637.18 EEA22601.1 - 3.6e-08 33.6 0.0 11 5.8 0.0 6.2 6 0 0 6 6 6 0 ATPase domain predominantly from Archaea TniB PF05621.11 EEA22601.1 - 8.2e-08 31.9 0.4 2.5 7.5 0.0 6.0 6 0 0 6 6 6 1 Bacterial TniB protein RuvB_N PF05496.12 EEA22601.1 - 1.3e-07 31.5 6.8 0.57 9.9 0.0 7.1 8 0 0 8 8 6 2 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EEA22601.1 - 1.7e-07 30.7 1.4 0.62 9.2 0.1 5.6 6 0 0 6 6 6 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EEA22601.1 - 2.8e-07 30.5 0.0 6 6.6 0.0 5.7 5 0 0 5 5 5 0 IstB-like ATP binding protein PduV-EutP PF10662.9 EEA22601.1 - 7.8e-07 28.9 3.8 0.45 10.2 0.0 6.2 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 EEA22601.1 - 2.2e-06 27.3 1.3 23 4.8 0.1 6.3 6 0 0 6 6 6 0 P-loop containing region of AAA domain Roc PF08477.13 EEA22601.1 - 3.2e-06 27.4 2.4 6 7.1 0.0 6.4 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EEA22601.1 - 3.5e-06 27.1 1.5 0.45 10.6 0.0 6.0 6 0 0 6 6 6 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EEA22601.1 - 6.6e-06 26.0 0.3 5.3 6.7 0.0 5.7 6 0 0 6 6 6 0 AAA domain CbiA PF01656.23 EEA22601.1 - 7.7e-06 26.0 0.0 0.15 12.1 0.0 3.7 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain MCM PF00493.23 EEA22601.1 - 1.2e-05 24.6 0.1 0.38 9.8 0.0 4.7 5 0 0 5 5 5 1 MCM P-loop domain AAA_28 PF13521.6 EEA22601.1 - 1.6e-05 25.2 9.7 0.8 9.9 0.3 6.0 6 0 0 6 6 5 2 AAA domain ResIII PF04851.15 EEA22601.1 - 0.00019 21.5 0.5 7.9 6.4 0.0 5.0 5 0 0 5 5 4 0 Type III restriction enzyme, res subunit Bac_DnaA PF00308.18 EEA22601.1 - 0.00027 20.9 0.0 2.9 7.7 0.0 3.8 3 0 0 3 3 3 0 Bacterial dnaA protein SRPRB PF09439.10 EEA22601.1 - 0.00034 20.1 2.1 8.8 5.7 0.0 5.5 6 0 0 6 6 5 0 Signal recognition particle receptor beta subunit TIP49 PF06068.13 EEA22601.1 - 0.00073 18.8 1.5 4 6.5 0.0 4.6 5 0 0 5 5 5 0 TIP49 P-loop domain CPT PF07931.12 EEA22601.1 - 0.00089 19.1 1.2 0.84 9.5 0.0 5.5 6 1 0 6 6 3 1 Chloramphenicol phosphotransferase-like protein Viral_helicase1 PF01443.18 EEA22601.1 - 0.0035 17.1 0.0 13 5.4 0.0 4.3 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase DnaB_C PF03796.15 EEA22601.1 - 0.0093 15.3 3.2 1.8 7.8 0.1 4.4 4 0 0 4 4 4 1 DnaB-like helicase C terminal domain KTI12 PF08433.10 EEA22601.1 - 0.013 14.9 0.3 9.3 5.6 0.0 4.0 4 0 0 4 4 4 0 Chromatin associated protein KTI12 ATPase PF06745.13 EEA22601.1 - 0.015 14.6 0.4 15 4.8 0.0 4.2 4 0 0 4 4 3 0 KaiC KAP_NTPase PF07693.14 EEA22601.1 - 0.021 14.1 0.0 4.8 6.3 0.0 3.6 4 0 0 4 4 3 0 KAP family P-loop domain PhoH PF02562.16 EEA22601.1 - 0.041 13.3 0.4 3.4 7.1 0.0 3.6 4 0 0 4 4 3 0 PhoH-like protein dNK PF01712.19 EEA22601.1 - 0.045 13.6 0.5 22 4.8 0.0 3.8 3 0 0 3 3 3 0 Deoxynucleoside kinase AAA_21 PF13304.6 EEA22601.1 - 0.057 13.2 0.0 0.81 9.4 0.0 3.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF927 PF06048.11 EEA22601.1 - 0.057 13.0 0.0 5.1 6.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF927) PRK PF00485.18 EEA22601.1 - 0.058 13.1 0.3 2.2 8.0 0.0 3.5 5 0 0 5 5 2 0 Phosphoribulokinase / Uridine kinase family ATP_bind_1 PF03029.17 EEA22601.1 - 0.058 13.2 10.0 7.3 6.3 0.1 5.9 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 EEA22601.1 - 0.08 12.8 9.4 1.2 9.1 0.0 5.1 5 0 0 5 5 4 0 NTPase ATP-synt_ab PF00006.25 EEA22601.1 - 0.094 12.4 0.0 41 3.7 0.0 4.0 5 0 0 5 5 4 0 ATP synthase alpha/beta family, nucleotide-binding domain FeoB_N PF02421.18 EEA22601.1 - 0.13 11.8 5.5 2.3 7.7 0.0 4.6 5 0 0 5 5 5 0 Ferrous iron transport protein B Septin PF00735.18 EEA22601.1 - 0.15 11.4 2.0 26 4.0 0.1 3.7 4 0 0 4 4 3 0 Septin tRNA_lig_kinase PF08303.11 EEA22601.1 - 0.15 12.1 2.2 6.6 6.8 0.0 3.2 3 0 0 3 3 2 0 tRNA ligase kinase domain cobW PF02492.19 EEA22601.1 - 1.4 8.4 8.9 25 4.4 0.1 5.1 6 0 0 6 6 5 0 CobW/HypB/UreG, nucleotide-binding domain PRCC PF10253.9 EEA22602.1 - 1.9e-35 123.6 18.2 1.9e-35 123.6 18.2 3.0 1 1 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Lectin_leg-like PF03388.13 EEA22604.1 - 9.5e-67 224.7 0.0 1.3e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EEA22604.1 - 7.2e-09 35.9 0.1 9.8e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EEA22604.1 - 1.6e-05 24.6 0.0 0.011 15.2 0.0 2.1 2 0 0 2 2 2 2 Legume lectin domain zf-Tim10_DDP PF02953.15 EEA22605.1 - 6.1e-21 73.8 0.1 8.8e-21 73.3 0.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Pkinase PF00069.25 EEA22606.1 - 6.6e-73 245.3 0.0 9.4e-73 244.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22606.1 - 3e-37 128.3 0.0 4.5e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA22606.1 - 6.3e-06 25.7 0.1 1e-05 25.0 0.1 1.4 1 1 0 1 1 1 1 Kinase-like KCT2 PF17818.1 EEA22606.1 - 0.072 13.2 7.2 0.13 12.4 7.2 1.3 1 0 0 1 1 1 0 Keratinocyte-associated gene product Hid1 PF12722.7 EEA22606.1 - 5.8 4.9 12.3 7.4 4.6 12.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CRIM PF16978.5 EEA22607.1 - 1.5e-36 125.6 0.0 3e-36 124.6 0.0 1.6 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EEA22607.1 - 5.3e-26 91.0 0.1 9e-26 90.3 0.1 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 EEA22607.1 - 0.033 14.4 0.0 0.14 12.4 0.0 2.0 2 0 0 2 2 2 0 TUG ubiquitin-like domain RFC1 PF08519.12 EEA22608.1 - 2.8e-58 196.5 0.0 9.9e-58 194.7 0.0 1.9 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EEA22608.1 - 2.8e-15 56.4 0.0 8e-15 55.0 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EEA22608.1 - 1e-09 38.9 1.2 1.7e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EEA22608.1 - 1.5e-06 28.3 0.0 4.4e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EEA22608.1 - 2.7e-05 24.5 0.0 6.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EEA22608.1 - 7e-05 22.6 0.0 0.007 16.1 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA22608.1 - 0.00043 20.7 0.0 0.0062 16.9 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EEA22608.1 - 0.0009 19.4 0.0 0.0026 17.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EEA22608.1 - 0.0063 16.8 1.1 0.19 12.0 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EEA22608.1 - 0.01 15.6 0.0 0.01 15.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EEA22608.1 - 0.017 15.7 0.0 0.079 13.5 0.0 2.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EEA22608.1 - 0.021 14.6 0.1 0.051 13.3 0.1 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 EEA22608.1 - 0.027 14.5 0.0 0.089 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EEA22608.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA22608.1 - 0.068 13.1 0.0 0.99 9.3 0.0 2.3 2 0 0 2 2 2 0 NACHT domain PTCB-BRCT PF12738.7 EEA22608.1 - 0.12 12.3 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain NTPase_1 PF03266.15 EEA22608.1 - 0.13 12.1 0.1 0.36 10.7 0.1 1.7 1 1 1 2 2 2 0 NTPase AAA_11 PF13086.6 EEA22608.1 - 2.1 8.1 11.0 1.2 8.9 0.0 3.5 3 0 0 3 3 3 0 AAA domain AT_hook PF02178.19 EEA22608.1 - 6 7.1 11.2 0.048 13.5 1.8 2.9 2 0 0 2 2 1 0 AT hook motif Ribosomal_L16 PF00252.18 EEA22609.1 - 1.2e-30 106.3 0.3 1.4e-30 106.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e HTH_12 PF08461.10 EEA22609.1 - 0.1 12.6 0.1 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain DNA_pol3_delta2 PF13177.6 EEA22611.1 - 4.3e-11 42.9 0.1 9.5e-11 41.7 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EEA22611.1 - 1.3e-06 28.9 0.0 2.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA22611.1 - 6.3e-06 26.5 0.0 3e-05 24.3 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA22611.1 - 0.0011 19.4 0.6 0.0077 16.6 0.3 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EEA22611.1 - 0.0018 18.0 0.2 0.0047 16.7 0.2 1.6 1 1 0 1 1 1 1 AAA domain Rep_fac_C PF08542.11 EEA22611.1 - 0.0024 18.3 0.1 0.0063 16.9 0.0 1.8 2 0 0 2 2 2 1 Replication factor C C-terminal domain ABC_tran PF00005.27 EEA22611.1 - 0.017 15.6 0.1 0.028 14.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter Rad17 PF03215.15 EEA22611.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain DNA_pol3_delta PF06144.13 EEA22611.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit T4SS-DNA_transf PF02534.14 EEA22611.1 - 0.1 11.3 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer CtaG_Cox11 PF04442.14 EEA22612.1 - 1.2e-61 207.2 0.0 1.9e-61 206.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 CENP-Q PF13094.6 EEA22613.1 - 5.3e-44 150.4 5.8 1.1e-43 149.3 5.8 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit HLH PF00010.26 EEA22614.1 - 7.2e-08 32.3 0.0 1.6e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ORC6 PF05460.13 EEA22614.1 - 0.11 11.7 13.3 0.2 10.9 13.3 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) TMEM135_C_rich PF15982.5 EEA22615.1 - 0.0047 17.5 0.4 0.027 15.1 0.3 2.3 2 1 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 HEPN_SAV_6107 PF18726.1 EEA22615.1 - 0.82 10.2 11.3 0.7 10.4 2.6 2.8 2 1 0 2 2 2 0 SAV_6107-like HEPN Ank_4 PF13637.6 EEA22617.1 - 0.12 12.9 0.3 8.4 7.1 0.1 2.4 2 1 0 2 2 2 0 Ankyrin repeats (many copies) WD40 PF00400.32 EEA22620.1 - 1.5e-15 57.3 4.9 0.088 13.7 0.0 8.0 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA22620.1 - 0.0004 20.6 0.1 14 6.1 0.0 5.2 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Glyco_hydro_71 PF03659.14 EEA22621.1 - 2.5e-96 322.8 5.3 3.5e-96 322.3 5.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 MCM_N PF14551.6 EEA22621.1 - 0.17 12.5 0.0 0.56 10.8 0.0 1.9 2 0 0 2 2 2 0 MCM N-terminal domain PAP1 PF08601.10 EEA22621.1 - 7.5 6.2 9.5 11 5.6 9.5 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Neugrin PF06413.11 EEA22622.1 - 6.6e-13 49.2 1.1 6.6e-13 49.2 1.1 1.7 2 0 0 2 2 2 1 Neugrin MRP-L20 PF12824.7 EEA22622.1 - 0.00014 22.1 11.5 0.00029 21.0 11.6 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Skp1 PF01466.19 EEA22622.1 - 0.047 13.8 1.1 0.1 12.7 1.1 1.6 1 0 0 1 1 1 0 Skp1 family, dimerisation domain US2 PF02476.15 EEA22622.1 - 2.8 8.6 9.6 4.5 8.0 2.0 2.5 1 1 0 2 2 2 0 US2 family Rgp1 PF08737.10 EEA22623.1 - 7.5e-142 473.4 0.0 1.7e-141 472.2 0.0 1.6 2 0 0 2 2 2 1 Rgp1 Arrestin_N PF00339.29 EEA22623.1 - 5.6e-05 23.2 0.1 0.00018 21.6 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 EEA22623.1 - 0.13 11.8 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 SpoOM protein Mob1_phocein PF03637.17 EEA22624.1 - 6.7e-73 244.2 0.0 9.1e-73 243.8 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family Mob1_phocein PF03637.17 EEA22625.1 - 3.6e-73 245.1 0.0 4.6e-73 244.8 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family Mob1_phocein PF03637.17 EEA22626.1 - 3.6e-73 245.1 0.0 4.6e-73 244.8 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family OSCP PF00213.18 EEA22627.1 - 4.6e-46 157.1 3.3 5.6e-46 156.8 3.3 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit EcoR124_C PF12008.8 EEA22627.1 - 0.012 15.2 0.3 0.015 14.9 0.3 1.1 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal DrrA_P4M PF14860.6 EEA22627.1 - 0.035 13.9 2.3 0.038 13.8 0.4 2.1 2 1 1 3 3 3 0 DrrA phosphatidylinositol 4-phosphate binding domain Glyco_hydro_63 PF03200.16 EEA22628.1 - 2.5e-07 29.8 2.6 2.5e-07 29.8 2.6 4.3 4 1 0 4 4 4 1 Glycosyl hydrolase family 63 C-terminal domain Esterase_phd PF10503.9 EEA22629.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase DUF4407 PF14362.6 EEA22629.1 - 0.43 9.9 5.9 0.51 9.7 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Plasmodium_Vir PF05795.11 EEA22629.1 - 1.4 8.3 4.8 1.6 8.1 4.8 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Bromodomain PF00439.25 EEA22630.1 - 4.8e-07 29.8 0.0 9.2e-06 25.6 0.0 2.5 1 1 0 1 1 1 1 Bromodomain Diphthamide_syn PF01866.17 EEA22631.1 - 1.9e-114 382.2 0.0 2.4e-114 381.9 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein HMGL-like PF00682.19 EEA22632.1 - 6.1e-45 153.8 0.1 9.6e-45 153.2 0.1 1.3 1 1 0 1 1 1 1 HMGL-like PE PF00934.20 EEA22632.1 - 0.73 10.2 2.8 0.49 10.7 0.2 2.1 2 1 0 2 2 2 0 PE family DUF1674 PF07896.12 EEA22633.1 - 1.1e-18 67.4 3.3 1.1e-18 67.4 3.3 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1674) TFIIF_alpha PF05793.12 EEA22633.1 - 0.052 12.1 2.3 0.062 11.9 2.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Aminotran_3 PF00202.21 EEA22634.1 - 3.5e-108 361.9 0.0 4.4e-108 361.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EEA22634.1 - 0.00075 18.8 0.0 0.0014 17.9 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Peptidase_S8 PF00082.22 EEA22637.1 - 1.1e-44 152.9 0.0 2.3e-44 151.9 0.0 1.5 1 1 0 1 1 1 1 Subtilase family Lactamase_B_2 PF12706.7 EEA22639.1 - 0.0039 16.7 0.0 0.0087 15.6 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Ank_2 PF12796.7 EEA22640.1 - 0.00035 21.1 0.2 0.029 14.9 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA22640.1 - 0.0012 19.2 2.5 0.0034 17.8 0.2 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EEA22640.1 - 0.0061 17.1 0.1 0.038 14.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA22640.1 - 0.025 14.9 0.0 1.9 8.9 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA22640.1 - 0.23 12.1 0.9 0.78 10.5 0.1 2.4 2 0 0 2 2 2 0 Ankyrin repeat Abhydrolase_3 PF07859.13 EEA22642.1 - 1e-33 117.0 0.0 2e-23 83.4 0.0 2.6 2 0 0 2 2 2 2 alpha/beta hydrolase fold Glyco_hydr_30_2 PF14587.6 EEA22643.1 - 9.6e-21 74.8 9.0 1.8e-20 73.9 9.0 1.4 1 0 0 1 1 1 1 O-Glycosyl hydrolase family 30 Glyco_hydro_59 PF02057.15 EEA22643.1 - 6.7e-08 32.1 1.9 1.1e-07 31.4 1.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 CLN3 PF02487.17 EEA22644.1 - 4.9e-160 532.9 5.1 5.7e-160 532.7 5.1 1.0 1 0 0 1 1 1 1 CLN3 protein DUF1772 PF08592.11 EEA22644.1 - 0.012 15.9 1.7 0.031 14.6 0.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Rxt3 PF08642.10 EEA22645.1 - 1.8e-43 148.3 0.0 6.2e-43 146.6 0.0 2.0 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EEA22645.1 - 0.00062 19.8 0.0 0.0022 18.1 0.0 1.9 2 0 0 2 2 2 1 LCCL domain adh_short PF00106.25 EEA22646.1 - 3.1e-35 121.4 0.1 4.1e-35 121.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22646.1 - 1.4e-28 100.0 0.0 1.6e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22646.1 - 4.4e-08 33.2 0.3 5.5e-08 32.9 0.3 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA22646.1 - 0.0012 18.7 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EEA22646.1 - 0.097 11.8 0.0 0.22 10.7 0.0 1.8 1 1 0 1 1 1 0 Male sterility protein Epimerase PF01370.21 EEA22646.1 - 0.11 12.0 0.1 0.32 10.4 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA22646.1 - 0.19 11.1 0.0 1.9 7.8 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase FAD_binding_3 PF01494.19 EEA22647.1 - 1.2e-08 34.6 0.0 7.8e-08 31.9 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain Aldo_ket_red PF00248.21 EEA22648.1 - 1.5e-65 221.3 0.0 1.8e-65 221.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Evf PF18270.1 EEA22648.1 - 0.048 13.1 0.0 0.093 12.1 0.0 1.4 2 0 0 2 2 2 0 Virulence factor Evf Pro_racemase PF05544.11 EEA22649.1 - 4.8e-47 160.6 0.0 7.3e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 Proline racemase Carn_acyltransf PF00755.20 EEA22650.1 - 1.6e-205 684.2 0.0 1.8e-205 684.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF2046 PF09755.9 EEA22651.1 - 0.0061 15.8 6.1 0.014 14.6 2.1 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) DUF3138 PF11336.8 EEA22651.1 - 0.0094 14.6 4.5 0.017 13.8 4.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3138) AAA_30 PF13604.6 EEA22651.1 - 0.04 13.6 0.4 0.04 13.6 0.4 2.0 2 1 1 3 3 3 0 AAA domain DivIC PF04977.15 EEA22651.1 - 0.076 12.8 0.1 0.076 12.8 0.1 2.4 2 0 0 2 2 2 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 EEA22651.1 - 0.46 10.7 8.1 0.44 10.8 0.2 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 SlyX PF04102.12 EEA22651.1 - 0.7 10.5 12.4 7.6 7.2 0.1 2.6 2 0 0 2 2 2 0 SlyX Lectin_C PF00059.21 EEA22652.1 - 0.0065 17.2 0.5 0.33 11.7 0.1 2.8 3 0 0 3 3 3 1 Lectin C-type domain Sec62 PF03839.16 EEA22653.1 - 7.8e-74 247.8 1.0 7.8e-74 247.8 1.0 1.6 2 0 0 2 2 2 1 Translocation protein Sec62 His_Phos_2 PF00328.22 EEA22654.1 - 1.6e-65 222.0 0.0 1.8e-65 221.8 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PH PF00169.29 EEA22655.1 - 0.04 14.4 0.0 0.094 13.2 0.0 1.7 1 0 0 1 1 1 0 PH domain Pyr_redox_2 PF07992.14 EEA22656.1 - 4.9e-09 35.8 0.0 2.2e-08 33.7 0.0 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA22656.1 - 0.0041 17.3 0.0 0.0089 16.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA22656.1 - 0.027 13.2 0.0 0.044 12.5 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 EEA22656.1 - 0.076 12.1 0.0 0.85 8.6 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 EEA22656.1 - 0.12 12.4 0.0 0.29 11.1 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 EEA22656.1 - 0.13 12.7 0.0 8.5 6.9 0.1 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding DUF726 PF05277.12 EEA22658.1 - 1.8e-116 388.8 2.8 2.5e-116 388.3 2.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Glu-tRNAGln PF02686.15 EEA22658.1 - 2.3e-06 27.8 0.3 1.2e-05 25.6 0.0 2.5 2 1 0 2 2 2 1 Glu-tRNAGln amidotransferase C subunit Thioesterase PF00975.20 EEA22658.1 - 0.018 15.1 0.3 0.098 12.7 0.0 2.3 2 0 0 2 2 2 0 Thioesterase domain DUF900 PF05990.12 EEA22658.1 - 0.025 14.1 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EEA22658.1 - 0.13 12.8 1.0 1.3 9.6 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family SNAP PF14938.6 EEA22659.1 - 4e-115 384.1 13.0 4.5e-115 383.9 13.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EEA22659.1 - 3.5e-07 30.4 10.5 0.00058 20.1 0.8 3.5 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA22659.1 - 0.01 15.8 10.2 6.6 7.0 1.0 5.2 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA22659.1 - 0.55 10.6 17.0 0.31 11.4 1.1 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA22659.1 - 1.5 8.8 19.1 0.94 9.4 0.2 5.8 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA22659.1 - 1.7 8.9 20.4 2.4 8.5 0.3 6.6 4 1 2 7 7 7 0 Tetratricopeptide repeat SNAP PF14938.6 EEA22660.1 - 8.5e-94 314.1 9.7 9.5e-94 314.0 9.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EEA22660.1 - 3.2e-06 27.3 7.5 0.00059 20.1 1.1 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA22660.1 - 0.043 13.9 6.7 5.8 7.2 1.2 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA22660.1 - 0.44 10.8 15.4 1.9 8.8 0.3 5.8 4 2 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA22660.1 - 1.1 9.2 12.5 0.74 9.7 0.2 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA22660.1 - 2.6 8.5 15.9 0.24 11.7 1.1 4.3 4 1 0 5 5 5 0 Tetratricopeptide repeat BING4CT PF08149.11 EEA22661.1 - 7.1e-39 131.5 0.0 2.3e-35 120.2 0.0 3.4 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EEA22661.1 - 9.1e-08 32.3 0.0 7.9 6.8 0.0 5.7 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA22661.1 - 0.0095 16.8 0.1 12 7.0 0.0 4.2 3 1 1 4 4 4 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EEA22661.1 - 0.026 13.6 0.0 0.051 12.6 0.0 1.4 1 1 0 1 1 1 0 Coatomer WD associated region RIBIOP_C PF04950.12 EEA22662.1 - 1.1e-110 369.7 0.0 3e-110 368.3 0.0 1.7 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EEA22662.1 - 1e-20 73.6 0.0 2.5e-20 72.4 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain cobW PF02492.19 EEA22663.1 - 3.7e-34 117.8 0.0 4.5e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EEA22663.1 - 8e-05 21.7 0.0 0.032 13.2 0.0 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EEA22663.1 - 0.063 13.4 0.0 0.22 11.6 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 EEA22663.1 - 0.071 13.0 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain CbiA PF01656.23 EEA22663.1 - 0.085 12.9 0.0 0.14 12.3 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ResIII PF04851.15 EEA22663.1 - 0.091 12.8 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 EEA22663.1 - 0.12 12.9 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA22663.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DDE_1 PF03184.19 EEA22664.1 - 1.2e-33 116.3 0.0 2.2e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22664.1 - 2.6e-10 40.2 0.4 1.7e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA22664.1 - 2e-06 27.4 0.0 5.3e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-CCHC_2 PF13696.6 EEA22664.1 - 0.079 12.8 1.5 0.14 12.0 1.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EEA22664.1 - 0.34 11.1 2.1 0.62 10.3 2.1 1.5 1 0 0 1 1 1 0 Zinc knuckle LIM_bind PF01803.16 EEA22666.1 - 3.5e-57 193.7 0.1 3.5e-57 193.7 0.1 4.6 2 1 0 3 3 3 1 LIM-domain binding protein DUF4050 PF13259.6 EEA22667.1 - 3.1e-52 177.6 0.3 3.1e-52 177.6 0.3 3.4 4 0 0 4 4 3 1 Protein of unknown function (DUF4050) AAA PF00004.29 EEA22667.1 - 4.8e-40 137.0 0.0 7.1e-38 130.0 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA22667.1 - 4.8e-11 42.3 0.0 1.3e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EEA22667.1 - 8e-05 23.1 0.1 0.0027 18.1 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EEA22667.1 - 0.00014 21.6 0.0 0.00037 20.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA22667.1 - 0.00042 20.6 0.3 0.067 13.5 0.1 3.4 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 EEA22667.1 - 0.00075 19.7 0.0 0.0032 17.6 0.0 2.2 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EEA22667.1 - 0.00087 18.6 0.3 0.0041 16.4 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 EEA22667.1 - 0.0033 17.4 0.0 0.0093 16.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EEA22667.1 - 0.018 15.1 0.0 0.074 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA22667.1 - 0.021 14.5 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EEA22667.1 - 0.026 14.8 0.0 0.1 12.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EEA22667.1 - 0.035 13.5 0.1 0.08 12.3 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA22667.1 - 0.063 13.7 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EEA22667.1 - 0.082 12.6 0.0 0.22 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EEA22667.1 - 0.094 12.1 0.0 3.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein AAA_18 PF13238.6 EEA22667.1 - 0.097 13.2 0.0 0.25 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF3237 PF11578.8 EEA22668.1 - 2.5e-33 115.0 0.0 3.5e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) zf-BED PF02892.15 EEA22668.1 - 0.0014 18.6 6.3 0.31 11.1 1.3 2.4 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_2 PF12756.7 EEA22668.1 - 0.084 13.2 4.8 5.5 7.4 0.6 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn_Tnp_IS91 PF14319.6 EEA22668.1 - 0.19 11.8 9.5 1.4 9.0 2.3 2.3 2 0 0 2 2 2 0 Transposase zinc-binding domain NAT PF04768.13 EEA22669.1 - 7.6e-55 185.2 0.1 1.6e-54 184.1 0.1 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EEA22669.1 - 5e-30 104.4 0.0 1.4e-29 103.0 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Rad21_Rec8_N PF04825.13 EEA22669.1 - 1.2e-29 102.7 0.0 2.4e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein AA_kinase PF00696.28 EEA22669.1 - 6.8e-28 97.9 0.0 1.2e-27 97.1 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family Rad21_Rec8 PF04824.16 EEA22669.1 - 0.024 13.9 0.0 0.056 12.7 0.0 1.5 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein DapB_N PF01113.20 EEA22669.1 - 0.039 14.1 0.0 0.14 12.3 0.0 2.0 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Synaptobrevin PF00957.21 EEA22670.1 - 4.4e-34 116.1 0.9 5.5e-34 115.8 0.9 1.0 1 0 0 1 1 1 1 Synaptobrevin AKNA PF12443.8 EEA22670.1 - 0.07 13.8 0.0 0.12 13.0 0.0 1.4 1 1 0 1 1 1 0 AT-hook-containing transcription factor Prominin PF05478.11 EEA22670.1 - 0.15 10.0 0.0 0.19 9.6 0.0 1.0 1 0 0 1 1 1 0 Prominin Synaptobrevin PF00957.21 EEA22671.1 - 3.4e-34 116.5 1.7 3.8e-34 116.3 1.7 1.0 1 0 0 1 1 1 1 Synaptobrevin AKNA PF12443.8 EEA22671.1 - 0.058 14.0 0.0 0.098 13.3 0.0 1.4 1 1 0 1 1 1 0 AT-hook-containing transcription factor adh_short PF00106.25 EEA22672.1 - 6.5e-31 107.3 0.0 4.6e-29 101.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22672.1 - 2.7e-19 69.7 0.0 6.9e-19 68.3 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22672.1 - 0.0021 18.0 0.2 0.21 11.5 0.2 2.2 1 1 0 1 1 1 1 KR domain Glyco_hydro_28 PF00295.17 EEA22673.1 - 4.1e-47 160.8 14.0 5.9e-47 160.3 14.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 adh_short PF00106.25 EEA22674.1 - 1.4e-39 135.6 0.5 1.7e-39 135.3 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22674.1 - 5.7e-32 111.1 0.2 7.8e-32 110.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22674.1 - 2.4e-08 34.1 0.0 4.7e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 KR domain ACT_7 PF13840.6 EEA22674.1 - 0.045 13.5 0.1 0.15 11.9 0.1 1.9 1 0 0 1 1 1 0 ACT domain Epimerase PF01370.21 EEA22674.1 - 0.053 13.0 0.6 0.11 11.9 0.5 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Fungal_trans PF04082.18 EEA22675.1 - 6.9e-08 31.8 1.9 1.3e-07 30.9 1.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22675.1 - 1.7e-07 31.3 10.5 1.7e-07 31.3 10.5 3.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 EEA22675.1 - 6.1e-05 23.3 13.1 0.003 17.9 5.3 3.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA22675.1 - 0.00037 20.8 2.7 0.00037 20.8 2.7 4.0 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA22675.1 - 0.022 15.6 3.4 0.022 15.6 3.4 4.3 5 0 0 5 5 5 0 C2H2-type zinc finger FMO-like PF00743.19 EEA22676.1 - 6.1e-14 51.3 2.3 4.6e-13 48.4 0.5 2.6 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EEA22676.1 - 6.9e-12 45.4 0.0 1.7e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA22676.1 - 2.3e-07 30.7 0.0 0.0015 18.2 0.0 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA22676.1 - 2.4e-06 27.0 0.0 0.00017 20.9 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA22676.1 - 3e-05 23.4 0.2 0.0017 17.6 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EEA22676.1 - 8.2e-05 22.0 0.0 0.0017 17.7 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA22676.1 - 0.00012 22.1 0.4 0.0034 17.4 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EEA22676.1 - 0.0047 16.2 0.1 0.49 9.6 0.0 2.8 3 0 0 3 3 3 1 Thi4 family p450 PF00067.22 EEA22677.1 - 6.7e-53 180.1 0.0 9.2e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Consortin_C PF15281.6 EEA22677.1 - 0.087 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Consortin C-terminus DDE_Tnp_1_7 PF13843.6 EEA22678.1 - 1.1e-35 123.6 0.3 1e-18 67.8 0.0 2.2 2 0 0 2 2 2 2 Transposase IS4 zf-C2H2 PF00096.26 EEA22679.1 - 1.1e-07 31.9 15.8 0.0014 19.0 4.8 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA22679.1 - 0.00018 21.8 14.0 0.00054 20.3 1.6 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA22679.1 - 0.0047 17.7 14.4 0.38 11.7 2.7 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EEA22679.1 - 0.15 12.2 2.3 8.6 6.6 0.3 2.3 2 0 0 2 2 2 0 Zinc ribbon domain zf-BED PF02892.15 EEA22679.1 - 3 7.9 11.8 1.1 9.4 3.1 2.7 1 1 1 2 2 2 0 BED zinc finger Hamartin PF04388.12 EEA22679.1 - 4.5 5.8 16.7 4.9 5.7 16.7 1.2 1 0 0 1 1 1 0 Hamartin protein zf-met PF12874.7 EEA22679.1 - 5.3 7.6 9.1 0.88 10.0 2.4 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type MFS_1 PF07690.16 EEA22680.1 - 1.8e-25 89.6 52.6 1.4e-24 86.7 39.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily F-box-like PF12937.7 EEA22681.1 - 0.0014 18.5 0.0 0.0035 17.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA22681.1 - 0.015 15.1 0.1 0.045 13.7 0.1 1.9 1 1 0 1 1 1 0 F-box domain Enolase_like_N PF18374.1 EEA22681.1 - 0.25 10.7 1.8 2.5 7.6 0.3 2.3 2 0 0 2 2 2 0 Enolase N-terminal domain-like p450 PF00067.22 EEA22682.1 - 5.3e-69 233.1 0.0 7.3e-69 232.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 BTB PF00651.31 EEA22683.1 - 9.5e-24 83.8 0.0 3.4e-13 49.8 0.8 2.7 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 EEA22683.1 - 5.5e-08 33.2 0.0 1.5e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA22683.1 - 2.7e-06 27.9 0.0 6e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA22683.1 - 3.2e-06 27.3 0.0 9.2e-06 25.8 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EEA22683.1 - 0.00013 22.2 0.0 0.014 15.8 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EEA22683.1 - 0.017 15.6 0.2 0.35 11.6 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat DUF3342 PF11822.8 EEA22683.1 - 0.064 13.5 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Pkinase PF00069.25 EEA22684.1 - 1.1e-54 185.5 0.1 2.8e-34 118.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22684.1 - 7.7e-35 120.4 0.0 5.1e-24 85.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA22684.1 - 0.01 14.7 2.6 0.2 10.4 0.0 2.4 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 EEA22684.1 - 0.041 13.2 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF3896 PF13035.6 EEA22684.1 - 0.18 12.0 1.5 0.5 10.6 0.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3896) Wbp11 PF09429.10 EEA22685.1 - 3.1e-21 75.5 14.1 3.1e-21 75.5 14.1 2.7 2 1 1 3 3 3 1 WW domain binding protein 11 DUF3040 PF11239.8 EEA22685.1 - 3.3 8.0 5.1 25 5.2 5.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) Cobalamin_bind PF01122.19 EEA22686.1 - 0.0028 16.6 0.3 0.0038 16.2 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF1664 PF07889.12 EEA22686.1 - 0.01 15.9 1.4 0.041 13.9 1.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Nbl1_Borealin_N PF10444.9 EEA22686.1 - 0.031 13.9 1.5 0.37 10.5 0.4 2.6 2 1 0 2 2 2 0 Nbl1 / Borealin N terminal DUF4407 PF14362.6 EEA22686.1 - 0.045 13.1 1.7 0.047 13.0 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) POX PF07526.11 EEA22686.1 - 0.063 13.8 0.1 0.088 13.4 0.1 1.3 1 0 0 1 1 1 0 Associated with HOX CdvA PF18822.1 EEA22686.1 - 0.063 13.1 1.3 1.1 9.1 1.2 2.3 1 1 0 1 1 1 0 CdvA-like coiled-coil domain Fib_alpha PF08702.10 EEA22686.1 - 0.23 11.6 1.2 0.43 10.7 1.2 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 EEA22686.1 - 0.25 11.4 4.5 0.65 10.0 1.0 2.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rpr2 PF04032.16 EEA22687.1 - 3.3e-22 78.6 1.3 5.1e-22 78.0 1.3 1.3 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain NECFESHC PF16621.5 EEA22687.1 - 0.15 12.1 2.5 0.3 11.1 2.5 1.5 1 0 0 1 1 1 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 DEAD PF00270.29 EEA22688.1 - 2.1e-34 118.8 0.0 4.2e-34 117.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA22688.1 - 5.4e-27 94.3 0.1 2.9e-24 85.5 0.1 2.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EEA22688.1 - 1.8e-08 34.6 0.0 4.4e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EEA22688.1 - 0.0006 19.2 0.1 0.0045 16.4 0.0 2.1 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Lipase_GDSL PF00657.22 EEA22689.1 - 2.4e-10 40.7 0.1 3.1e-10 40.3 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL PF00657.22 EEA22690.1 - 1.2e-07 31.9 0.0 1.3e-07 31.8 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase T5orf172 PF10544.9 EEA22691.1 - 4.4e-05 24.0 0.0 0.00014 22.4 0.0 1.8 2 0 0 2 2 2 1 T5orf172 domain K_oxygenase PF13434.6 EEA22691.1 - 0.011 14.9 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) ApbA PF02558.16 EEA22693.1 - 1.4e-23 83.2 0.0 2.1e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EEA22693.1 - 5.4e-20 71.9 0.0 8e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal AGH PF17558.2 EEA22693.1 - 0.24 11.6 0.2 0.6 10.3 0.2 1.7 1 1 0 1 1 1 0 Androgenic gland hormone DASH_Hsk3 PF08227.11 EEA22694.1 - 6.2e-22 77.7 0.7 7.8e-22 77.4 0.7 1.1 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like BBS2_C PF14782.6 EEA22694.1 - 0.025 13.3 0.0 0.03 13.1 0.0 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal His_Phos_1 PF00300.22 EEA22695.1 - 2.8e-31 108.7 1.2 2.9e-15 56.5 0.0 3.3 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) Ank_2 PF12796.7 EEA22696.1 - 1.5e-76 253.0 5.7 2.6e-19 69.6 0.2 6.4 1 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA22696.1 - 8.1e-66 217.6 13.2 2.6e-11 43.8 0.0 9.4 3 1 6 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA22696.1 - 4.9e-62 198.5 0.2 1.9e-05 24.7 0.0 13.1 13 0 0 13 13 13 11 Ankyrin repeat Ank PF00023.30 EEA22696.1 - 2.7e-61 201.5 9.5 1.1e-05 25.6 0.0 12.5 13 0 0 13 13 13 11 Ankyrin repeat Ank_5 PF13857.6 EEA22696.1 - 4.2e-55 183.1 5.5 3.4e-10 40.0 0.1 8.6 4 3 5 9 9 9 9 Ankyrin repeats (many copies) F-box-like PF12937.7 EEA22696.1 - 0.00018 21.4 2.2 0.00019 21.3 0.6 1.9 2 0 0 2 2 2 1 F-box-like PEGA PF08308.11 EEA22696.1 - 0.012 15.5 0.1 28 4.7 0.0 5.5 7 0 0 7 7 7 0 PEGA domain Pkinase PF00069.25 EEA22697.1 - 4.3e-20 72.2 0.0 1e-19 70.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22697.1 - 1.7e-07 30.8 0.0 6.2e-07 29.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EEA22697.1 - 0.023 14.0 0.0 0.52 9.6 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA22697.1 - 0.047 12.5 0.0 0.07 11.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase PHD PF00628.29 EEA22698.1 - 2.3e-05 24.2 10.5 3.9e-05 23.5 10.5 1.4 1 0 0 1 1 1 1 PHD-finger ZapB PF06005.12 EEA22698.1 - 0.026 15.0 4.1 0.026 15.0 4.1 3.0 3 0 0 3 3 3 0 Cell division protein ZapB Fzo_mitofusin PF04799.13 EEA22698.1 - 0.032 13.8 5.0 0.18 11.3 1.6 2.2 1 1 0 2 2 2 0 fzo-like conserved region bZIP_1 PF00170.21 EEA22698.1 - 0.034 14.2 6.9 0.41 10.8 3.8 2.4 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.15 EEA22698.1 - 0.037 13.8 15.6 0.38 10.6 0.1 2.8 3 1 0 3 3 2 0 Septum formation initiator TMF_DNA_bd PF12329.8 EEA22698.1 - 0.079 13.0 10.6 0.95 9.5 0.1 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Phage_GP20 PF06810.11 EEA22698.1 - 0.097 12.5 4.4 0.3 10.9 2.5 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF4140 PF13600.6 EEA22698.1 - 0.12 12.8 2.3 6.9 7.2 0.9 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) PI3K_P85_iSH2 PF16454.5 EEA22698.1 - 0.15 11.7 5.5 0.58 9.7 5.5 1.8 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain APC_N_CC PF16689.5 EEA22698.1 - 0.25 11.4 4.2 0.19 11.8 0.6 2.2 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Zf_RING PF16744.5 EEA22698.1 - 0.36 11.0 9.0 0.24 11.5 6.7 1.9 1 1 1 2 2 2 0 KIAA1045 RING finger Lzipper-MIP1 PF14389.6 EEA22698.1 - 0.36 11.1 3.3 4.1 7.8 0.1 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 GAS PF13851.6 EEA22698.1 - 0.39 10.0 7.0 1.6 8.0 7.0 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding HAP1_N PF04849.13 EEA22698.1 - 0.4 9.8 7.8 1.9 7.6 7.5 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region TPR_MLP1_2 PF07926.12 EEA22698.1 - 0.66 10.0 11.0 7.5 6.6 5.7 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Seryl_tRNA_N PF02403.22 EEA22698.1 - 0.67 10.2 6.2 0.82 9.9 3.6 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TSC22 PF01166.18 EEA22698.1 - 1 9.7 5.3 1.6 9.1 0.4 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family PHD_2 PF13831.6 EEA22698.1 - 1.1 8.9 9.6 0.039 13.5 3.4 1.8 2 0 0 2 2 2 0 PHD-finger Swi5 PF07061.11 EEA22698.1 - 1.3 9.2 4.9 37 4.5 3.0 2.5 2 0 0 2 2 2 0 Swi5 THOC7 PF05615.13 EEA22698.1 - 2.4 8.4 8.4 1.6 9.0 4.9 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 XRN_M PF17846.1 EEA22698.1 - 3 6.7 7.0 0.14 11.1 1.4 1.5 2 0 0 2 2 2 0 Xrn1 helical domain Fez1 PF06818.15 EEA22698.1 - 3.2 8.2 10.5 0.56 10.6 6.2 1.9 2 1 0 2 2 1 0 Fez1 NRBF2 PF08961.10 EEA22698.1 - 5.6 6.5 10.1 0.2 11.2 3.0 2.3 2 1 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator HALZ PF02183.18 EEA22698.1 - 6.5 7.1 6.6 4.7 7.5 1.1 2.6 3 0 0 3 3 2 0 Homeobox associated leucine zipper AdoMet_MTase PF07757.13 EEA22699.1 - 7.6e-36 122.9 0.4 3.7e-35 120.6 0.4 2.0 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase SMC_N PF02463.19 EEA22700.1 - 1.6e-22 80.0 0.0 3.4e-22 79.0 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EEA22700.1 - 1.1e-20 75.0 0.2 1.1e-20 75.0 0.2 5.2 2 2 1 3 3 2 1 AAA domain AAA_15 PF13175.6 EEA22700.1 - 1.3e-13 51.4 0.1 6.6e-07 29.4 1.1 3.9 1 1 1 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EEA22700.1 - 0.0002 21.3 7.1 0.012 15.4 0.0 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA22700.1 - 0.00029 20.5 0.0 0.00061 19.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.11 EEA22700.1 - 0.0037 16.2 14.1 0.0037 16.2 14.1 5.2 2 2 4 6 6 6 1 Spc7 kinetochore protein AAA_27 PF13514.6 EEA22700.1 - 0.011 15.4 0.0 0.011 15.4 0.0 4.4 6 0 0 6 6 6 0 AAA domain NPV_P10 PF05531.12 EEA22700.1 - 0.021 15.2 14.1 0.91 10.0 0.1 5.5 3 1 2 5 5 5 0 Nucleopolyhedrovirus P10 protein AAA_25 PF13481.6 EEA22700.1 - 0.09 12.3 0.6 0.61 9.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Chrome_Resist PF09828.9 EEA22700.1 - 0.14 12.6 1.0 0.58 10.6 1.0 2.1 1 0 0 1 1 1 0 Chromate resistance exported protein Hemagglutinin PF00509.18 EEA22700.1 - 0.25 9.7 8.0 1.2 7.5 0.3 2.6 3 0 0 3 3 3 0 Haemagglutinin Fib_alpha PF08702.10 EEA22700.1 - 0.3 11.3 0.0 0.3 11.3 0.0 5.8 3 2 2 6 6 6 0 Fibrinogen alpha/beta chain family Ax_dynein_light PF10211.9 EEA22701.1 - 0.0012 18.9 0.4 0.0013 18.7 0.4 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain HemX PF04375.14 EEA22701.1 - 0.0085 15.4 0.8 0.0092 15.3 0.8 1.0 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase COX7a PF02238.15 EEA22701.1 - 0.035 14.5 0.4 0.071 13.5 0.4 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII HWE_HK PF07536.14 EEA22701.1 - 0.048 14.4 0.5 0.064 14.0 0.5 1.2 1 0 0 1 1 1 0 HWE histidine kinase DUF5082 PF16888.5 EEA22701.1 - 0.062 13.6 3.2 0.084 13.2 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) MerR-DNA-bind PF09278.11 EEA22701.1 - 3.7 8.2 6.7 18 6.0 0.6 2.2 1 1 1 2 2 2 0 MerR, DNA binding Lipase_3 PF01764.25 EEA22702.1 - 2.3e-18 66.4 0.0 2.7e-16 59.7 0.0 2.5 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EEA22702.1 - 0.015 15.9 2.7 0.037 14.6 0.1 2.6 3 0 0 3 3 3 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA22702.1 - 0.03 13.6 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 FMN_dh PF01070.18 EEA22703.1 - 7.4e-36 123.9 0.9 8.5e-36 123.7 0.9 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EEA22703.1 - 1.4e-05 24.4 0.2 1.9e-05 24.0 0.2 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EEA22703.1 - 2.1e-05 23.7 0.9 3.2e-05 23.1 1.0 1.3 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EEA22703.1 - 0.0093 15.4 0.3 0.019 14.4 0.1 1.5 1 1 1 2 2 2 1 Histidine biosynthesis protein IGPS PF00218.21 EEA22703.1 - 0.01 15.0 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase ThiG PF05690.14 EEA22703.1 - 0.018 14.3 0.2 0.025 13.9 0.2 1.1 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG NMO PF03060.15 EEA22703.1 - 0.07 12.5 0.4 0.073 12.5 0.4 1.1 1 0 0 1 1 1 0 Nitronate monooxygenase DHO_dh PF01180.21 EEA22703.1 - 0.07 12.3 0.2 0.091 12.0 0.2 1.1 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EEA22704.1 - 1.3e-48 165.8 0.0 1.5e-48 165.6 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_Phos_2 PF00328.22 EEA22705.1 - 6.2e-35 121.3 0.0 8.1e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) HAS-barrel PF09378.10 EEA22706.1 - 0.04 14.1 0.4 0.091 12.9 0.4 1.5 1 0 0 1 1 1 0 HAS barrel domain NAC PF01849.18 EEA22708.1 - 3.2e-25 87.9 0.7 5.2e-25 87.2 0.7 1.3 1 0 0 1 1 1 1 NAC domain adh_short PF00106.25 EEA22709.1 - 7.1e-18 64.8 0.0 1.8e-13 50.4 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22709.1 - 1e-09 38.3 0.1 1.8e-07 31.0 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22709.1 - 2.1e-05 24.5 0.2 4.6e-05 23.4 0.1 1.5 2 0 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 EEA22709.1 - 0.034 14.4 0.1 0.062 13.6 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Abhydrolase_2 PF02230.16 EEA22710.1 - 4.5e-60 203.1 0.0 5.3e-60 202.9 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EEA22710.1 - 3.6e-06 26.4 0.8 0.006 15.9 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.18 EEA22710.1 - 0.00015 21.4 0.0 0.00022 20.9 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF2920 PF11144.8 EEA22710.1 - 0.0004 19.7 0.1 0.62 9.2 0.1 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF2920) FSH1 PF03959.13 EEA22710.1 - 0.00058 19.6 0.0 0.0018 18.0 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EEA22710.1 - 0.0015 18.2 0.3 1.9 8.1 0.1 3.0 2 1 1 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA22710.1 - 0.0016 18.0 0.0 0.076 12.5 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EEA22710.1 - 0.0017 18.3 0.0 0.28 11.0 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA22710.1 - 0.0057 17.3 0.0 0.0079 16.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1581 PF07619.11 EEA22710.1 - 0.033 14.3 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1581) Abhydrolase_2 PF02230.16 EEA22711.1 - 1.4e-41 142.7 0.0 1.6e-41 142.5 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EEA22711.1 - 1.6e-05 24.3 0.3 0.0035 16.6 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EEA22711.1 - 7.6e-05 22.4 0.0 9.5e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF2920 PF11144.8 EEA22711.1 - 0.00016 21.0 0.1 0.31 10.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2920) Abhydrolase_3 PF07859.13 EEA22711.1 - 0.0007 19.5 0.0 0.19 11.6 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA22711.1 - 0.00072 19.1 0.0 0.039 13.4 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EEA22711.1 - 0.029 14.0 0.1 1.1 8.9 0.1 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EEA22712.1 - 3.1e-54 184.1 0.0 3.6e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EEA22712.1 - 0.00027 20.3 0.2 0.83 8.9 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DUF2920 PF11144.8 EEA22712.1 - 0.00039 19.7 0.0 0.54 9.4 0.0 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF2920) FSH1 PF03959.13 EEA22712.1 - 0.00049 19.8 0.0 0.0014 18.3 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EEA22712.1 - 0.00088 19.0 0.3 1.7 8.2 0.1 3.0 2 1 1 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA22712.1 - 0.007 17.0 0.0 0.0091 16.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EEA22712.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF1581 PF07619.11 EEA22712.1 - 0.029 14.5 0.1 0.048 13.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1581) Abhydrolase_3 PF07859.13 EEA22712.1 - 0.079 12.8 0.0 0.22 11.4 0.0 1.7 1 1 1 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA22712.1 - 0.14 11.6 0.0 7.9 5.9 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family PAP1 PF08601.10 EEA22713.1 - 8.3 6.0 10.7 11 5.6 10.7 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Ctr PF04145.15 EEA22714.1 - 2.3e-17 64.0 0.2 2.4e-17 63.9 0.2 1.0 1 0 0 1 1 1 1 Ctr copper transporter family Papilloma_E5A PF05776.12 EEA22714.1 - 0.04 14.3 0.2 0.056 13.8 0.2 1.2 1 0 0 1 1 1 0 Papillomavirus E5A protein PAP2 PF01569.21 EEA22714.1 - 0.044 13.5 0.4 0.05 13.4 0.4 1.1 1 0 0 1 1 1 0 PAP2 superfamily FAD_binding_8 PF08022.12 EEA22715.1 - 2.7e-21 75.7 0.0 9.3e-21 74.0 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.12 EEA22715.1 - 1.8e-19 70.4 0.1 3.4e-19 69.5 0.1 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EEA22715.1 - 2.6e-19 69.6 13.2 6.9e-19 68.2 13.2 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 EEA22715.1 - 0.031 14.9 0.1 12 6.6 0.0 3.1 2 1 0 3 3 3 0 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EEA22715.1 - 0.06 13.7 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Robl_LC7 PF03259.17 EEA22716.1 - 0.00014 21.5 0.7 0.3 10.9 0.0 3.5 3 0 0 3 3 3 2 Roadblock/LC7 domain DLH PF01738.18 EEA22718.1 - 3.8e-12 46.2 0.1 5.2e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family zf-C2H2_4 PF13894.6 EEA22719.1 - 4.2e-09 36.5 9.6 0.00041 20.9 0.9 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA22719.1 - 2.7e-08 33.8 11.2 3.9e-05 23.9 0.8 3.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA22719.1 - 1.5e-06 28.4 15.8 3.1e-05 24.2 3.1 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-H2C2_5 PF13909.6 EEA22719.1 - 0.0014 18.4 7.6 0.22 11.3 0.2 2.7 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EEA22719.1 - 0.0043 17.3 4.1 0.084 13.2 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EEA22719.1 - 0.029 14.8 10.4 0.72 10.3 2.0 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 EEA22719.1 - 0.038 14.0 0.5 0.038 14.0 0.5 2.1 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_11 PF16622.5 EEA22719.1 - 0.078 12.8 2.6 2.6 7.9 0.3 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type BolA PF01722.18 EEA22719.1 - 0.098 12.9 1.4 1.1 9.6 0.6 2.4 1 1 1 2 2 2 0 BolA-like protein zf-AN1 PF01428.16 EEA22719.1 - 5.6 7.2 9.1 25 5.1 2.1 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger Pyridoxal_deC PF00282.19 EEA22720.1 - 6.4e-60 202.8 0.0 9e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EEA22720.1 - 0.00013 21.1 0.0 0.00022 20.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Fungal_trans_2 PF11951.8 EEA22721.1 - 1.7e-59 201.6 0.1 2.3e-59 201.1 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22721.1 - 9.1e-07 28.9 12.6 1.5e-06 28.2 12.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EutQ PF06249.12 EEA22722.1 - 1.1e-12 48.0 0.0 1.6e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 EEA22722.1 - 8.4e-10 38.2 0.0 1.4e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 EEA22722.1 - 5.7e-06 25.9 0.0 8.5e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Pirin PF02678.16 EEA22722.1 - 0.019 14.9 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Pirin KduI PF04962.12 EEA22722.1 - 0.061 12.6 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 KduI/IolB family Cupin_1 PF00190.22 EEA22722.1 - 0.098 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_6 PF12852.7 EEA22722.1 - 0.22 11.2 0.0 0.45 10.2 0.0 1.4 1 1 0 1 1 1 0 Cupin Pkinase PF00069.25 EEA22723.1 - 1.3e-60 205.0 0.0 8.5e-60 202.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22723.1 - 1.4e-28 99.9 0.3 6e-20 71.6 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EEA22723.1 - 9.8e-05 22.4 6.7 0.26 11.2 0.1 3.9 3 2 1 4 4 4 3 Phosphotransferase enzyme family Pkinase_C PF00433.24 EEA22723.1 - 0.00045 20.9 0.7 0.0013 19.4 0.7 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EEA22723.1 - 0.0026 17.1 0.1 0.013 14.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EEA22723.1 - 0.0061 15.5 0.1 0.01 14.8 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA22723.1 - 0.058 12.7 0.0 0.15 11.4 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Phage_connect_1 PF05135.13 EEA22724.1 - 0.029 14.9 0.1 0.045 14.3 0.1 1.4 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein HEPN_AbiA_CTD PF18732.1 EEA22724.1 - 0.049 13.6 0.1 0.079 12.9 0.1 1.3 1 0 0 1 1 1 0 HEPN like, Abia C-terminal domain DUF1687 PF07955.11 EEA22725.1 - 3.8e-24 85.6 0.0 1.1e-23 84.1 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) Ipi1_N PF12333.8 EEA22726.1 - 6.2e-28 97.4 0.3 6.8e-27 94.0 0.0 2.5 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation HEAT PF02985.22 EEA22726.1 - 0.0073 16.5 1.1 18 5.9 0.0 4.0 4 1 1 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EEA22726.1 - 0.015 15.8 4.2 0.59 10.7 0.3 3.9 3 1 1 4 4 4 0 HEAT-like repeat HEAT_2 PF13646.6 EEA22726.1 - 0.021 15.2 0.5 0.092 13.1 0.1 2.1 2 0 0 2 2 2 0 HEAT repeats Zn_clus PF00172.18 EEA22727.1 - 1.4e-08 34.7 6.9 2.1e-08 34.1 6.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Serglycin PF04360.12 EEA22728.1 - 0.13 12.2 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Serglycin Gly-zipper_YMGG PF13441.6 EEA22728.1 - 0.19 11.5 12.9 0.26 11.1 12.9 1.2 1 0 0 1 1 1 0 YMGG-like Gly-zipper GATA PF00320.27 EEA22729.1 - 1.7e-16 59.5 2.3 3.1e-16 58.7 2.3 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EEA22729.1 - 1.6e-12 47.0 2.6 3.1e-12 46.1 2.6 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) AreA_N PF07573.11 EEA22729.1 - 0.00032 21.3 3.1 0.00057 20.5 0.2 3.1 2 0 0 2 2 2 1 Nitrogen regulatory protein AreA N terminus DAO PF01266.24 EEA22730.1 - 2.7e-31 109.4 2.3 4.7e-30 105.3 2.3 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase TrkA_N PF02254.18 EEA22730.1 - 0.00041 20.6 0.0 0.00093 19.4 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox_2 PF07992.14 EEA22730.1 - 0.0013 18.0 1.9 0.39 9.9 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA22730.1 - 0.009 16.2 0.1 0.023 14.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EEA22730.1 - 0.028 13.3 0.5 4.3 6.1 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Sacchrp_dh_NADP PF03435.18 EEA22730.1 - 0.037 14.3 0.1 0.1 12.8 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Pyrid_oxidase_2 PF13883.6 EEA22731.1 - 3.6e-36 124.7 0.0 6.3e-36 123.9 0.0 1.4 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Cyclin PF08613.11 EEA22732.1 - 2e-06 28.3 0.0 2e-06 28.3 0.0 2.6 4 0 0 4 4 4 1 Cyclin Cyclin_N PF00134.23 EEA22732.1 - 0.00035 20.3 0.0 0.00083 19.1 0.0 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EEA22733.1 - 2e-06 28.3 0.0 2e-06 28.3 0.0 2.6 4 0 0 4 4 4 1 Cyclin Cyclin_N PF00134.23 EEA22733.1 - 0.00035 20.3 0.0 0.00083 19.1 0.0 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain RdRP PF05183.12 EEA22734.1 - 3.1e-182 607.3 0.0 4e-182 607.0 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase CorA PF01544.18 EEA22735.1 - 0.009 15.4 8.2 0.027 13.8 2.2 2.5 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein Pkinase PF00069.25 EEA22736.1 - 1.6e-19 70.4 0.1 4.5e-19 68.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22736.1 - 2.3e-15 56.6 0.0 4.1e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Drc1-Sld2 PF11719.8 EEA22738.1 - 8.2e-110 368.4 44.6 2.9e-108 363.3 44.6 2.0 1 1 0 1 1 1 1 DNA replication and checkpoint protein Fungal_trans PF04082.18 EEA22739.1 - 1.1e-11 44.3 0.1 2.1e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22739.1 - 1.1e-09 38.3 7.8 1.8e-09 37.6 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Suc_Fer-like PF06999.12 EEA22740.1 - 1.8e-67 227.0 0.0 2.2e-67 226.8 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like MARVEL PF01284.23 EEA22741.1 - 1.4e-23 83.5 6.1 1.8e-23 83.1 6.1 1.0 1 0 0 1 1 1 1 Membrane-associating domain NAGLU PF05089.12 EEA22743.1 - 5.3e-136 453.0 5.6 7e-136 452.5 5.6 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 EEA22743.1 - 6.5e-73 245.5 3.7 9.9e-73 244.9 3.7 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 EEA22743.1 - 1.3e-20 72.9 0.0 3.3e-20 71.6 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain DUF3446 PF11928.8 EEA22743.1 - 0.049 13.9 1.6 0.12 12.7 1.6 1.6 1 0 0 1 1 1 0 Early growth response N-terminal domain His_Phos_1 PF00300.22 EEA22744.1 - 6.4e-12 45.6 1.0 6.4e-12 45.6 1.0 2.2 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Ribosomal_L22 PF00237.19 EEA22746.1 - 4.5e-29 100.7 0.0 9.1e-29 99.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF1640 PF07798.11 EEA22747.1 - 6.4e-55 185.9 11.2 8.2e-55 185.5 11.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Uso1_p115_C PF04871.13 EEA22747.1 - 6.4 7.2 10.5 0.79 10.1 5.1 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DnaJ PF00226.31 EEA22748.1 - 4.7e-11 42.6 0.2 2.9e-10 40.1 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain Ank_4 PF13637.6 EEA22749.1 - 3.7e-42 142.2 1.2 6.6e-08 32.9 0.0 6.5 1 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA22749.1 - 8.8e-40 135.2 0.8 7.9e-12 45.6 0.0 4.5 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA22749.1 - 1.6e-22 79.2 0.7 0.0002 21.6 0.1 7.4 2 1 6 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EEA22749.1 - 4.7e-22 77.4 1.0 0.07 13.6 0.0 8.2 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.6 EEA22749.1 - 5.6e-18 63.2 0.0 0.48 11.2 0.0 8.0 8 0 0 8 8 8 5 Ankyrin repeat PNP_UDP_1 PF01048.20 EEA22749.1 - 3.3e-06 26.6 0.0 8.2e-06 25.2 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily YajC PF02699.15 EEA22749.1 - 0.0018 18.1 4.1 21 5.1 0.0 5.4 1 1 5 6 6 6 1 Preprotein translocase subunit Toprim_C_rpt PF13368.6 EEA22749.1 - 2.2 8.4 9.2 6.2 6.9 0.0 4.5 5 1 1 6 6 6 0 Topoisomerase C-terminal repeat PRA1 PF03208.19 EEA22751.1 - 6.6e-31 106.9 1.0 9.5e-31 106.3 1.0 1.2 1 0 0 1 1 1 1 PRA1 family protein YL1 PF05764.13 EEA22751.1 - 0.0082 16.3 20.6 0.027 14.6 3.1 2.2 2 0 0 2 2 2 2 YL1 nuclear protein CW_7 PF08230.11 EEA22751.1 - 0.022 14.5 0.5 8.7 6.2 0.2 2.6 2 0 0 2 2 2 0 CW_7 repeat Cwf_Cwc_15 PF04889.12 EEA22751.1 - 3.6 7.2 26.8 2.9 7.6 16.9 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF4611 PF15387.6 EEA22751.1 - 4.6 7.5 12.2 12 6.2 12.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 EEA22751.1 - 9 4.2 17.2 15 3.5 17.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Frag1 PF10277.9 EEA22752.1 - 2.6e-47 161.2 11.3 3e-47 161.0 11.3 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family CBP_BcsF PF11120.8 EEA22752.1 - 0.025 14.7 0.6 0.14 12.3 0.0 2.4 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF DUF2070 PF09843.9 EEA22752.1 - 9.6 4.4 11.3 3.8 5.7 8.7 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) Y_phosphatase3 PF13350.6 EEA22753.1 - 2.1e-36 126.1 0.0 2.9e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EEA22753.1 - 4.3e-08 32.9 0.0 6.8e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EEA22753.1 - 0.0031 17.1 0.0 0.0046 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EEA22753.1 - 0.021 14.6 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Myotub-related PF06602.14 EEA22753.1 - 0.073 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Glyco_hydro_35 PF01301.19 EEA22754.1 - 6.5e-80 269.1 3.9 9.9e-80 268.5 3.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EEA22754.1 - 1.5e-55 186.6 4.7 5.7e-29 101.0 0.0 3.4 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EEA22754.1 - 3.3e-50 170.4 7.1 6.3e-50 169.5 7.1 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EEA22754.1 - 3e-24 84.4 0.0 9.2e-24 82.8 0.0 1.9 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 Glyco_hydro_42 PF02449.15 EEA22754.1 - 5.2e-05 22.7 0.0 0.0065 15.9 0.0 2.3 2 0 0 2 2 2 2 Beta-galactosidase Cellulase PF00150.18 EEA22754.1 - 0.00026 20.5 0.2 0.0034 16.8 0.1 2.3 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DDE_1 PF03184.19 EEA22755.1 - 1.9e-24 86.2 0.0 3.6e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22755.1 - 5.5e-09 35.9 0.1 2.4e-08 33.9 0.1 2.2 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CAF-1_p150 PF11600.8 EEA22755.1 - 0.019 14.6 19.2 0.037 13.7 19.2 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal E1-E2_ATPase PF00122.20 EEA22756.1 - 3.7e-45 153.7 6.2 1.3e-44 151.9 6.2 2.1 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EEA22756.1 - 4.1e-26 92.6 0.0 6.5e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase FA_hydroxylase PF04116.13 EEA22756.1 - 2.4e-22 79.7 11.6 2.4e-22 79.7 11.6 2.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily HMA PF00403.26 EEA22756.1 - 7.5e-07 29.5 0.3 2e-06 28.1 0.1 1.9 2 0 0 2 2 2 1 Heavy-metal-associated domain Fungal_trans PF04082.18 EEA22757.1 - 8.7e-09 34.8 0.1 1.7e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA22757.1 - 2.3e-06 27.7 8.7 3.3e-05 24.1 3.3 3.2 2 0 0 2 2 2 1 Zinc finger, C2H2 type Zn_clus PF00172.18 EEA22757.1 - 0.00026 21.0 3.3 0.00026 21.0 3.3 2.2 2 0 0 2 2 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 EEA22757.1 - 0.00033 21.2 2.7 0.00033 21.2 2.7 3.5 3 0 0 3 3 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA22757.1 - 0.01 16.2 10.7 0.31 11.6 1.1 3.1 3 0 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.12 EEA22757.1 - 0.017 15.4 5.7 0.04 14.2 5.7 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 EEA22757.1 - 0.02 14.8 8.3 0.11 12.5 3.1 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-met PF12874.7 EEA22757.1 - 0.16 12.4 4.5 5.9 7.4 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EEA22757.1 - 0.32 10.8 4.1 1.3 8.9 4.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EEA22757.1 - 0.33 11.3 11.6 4 7.8 0.8 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EEA22757.1 - 0.35 10.9 5.4 8.7 6.5 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger TRAF6_Z2 PF18048.1 EEA22757.1 - 0.4 10.8 5.6 8.9 6.5 0.1 2.7 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 DUF2225 PF09986.9 EEA22757.1 - 0.63 9.7 4.0 0.36 10.5 0.9 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Zn-C2H2_12 PF18112.1 EEA22757.1 - 0.81 10.2 6.0 5.6 7.5 1.6 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Eisosome1 PF12757.7 EEA22758.1 - 7.3e-40 136.1 16.4 7.3e-40 136.1 16.4 3.5 4 1 0 4 4 4 1 Eisosome protein 1 MFS_1 PF07690.16 EEA22759.1 - 6.6e-35 120.7 19.2 6.6e-35 120.7 19.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA22759.1 - 2.1e-06 26.9 33.9 6.6e-06 25.2 3.7 4.5 3 2 1 4 4 4 3 Sugar (and other) transporter Phage_holin_3_1 PF05106.12 EEA22759.1 - 5 7.6 6.7 13 6.3 0.1 2.8 3 0 0 3 3 3 0 Phage holin family (Lysis protein S) MFS_1 PF07690.16 EEA22760.1 - 2.6e-34 118.7 22.9 3.7e-34 118.2 22.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA22760.1 - 1e-06 27.9 28.5 5.6e-06 25.5 3.7 3.7 3 1 1 4 4 4 3 Sugar (and other) transporter FPN1 PF06963.12 EEA22760.1 - 0.002 16.8 0.3 0.036 12.6 0.0 2.5 2 1 0 2 2 2 1 Ferroportin1 (FPN1) CFEM PF05730.11 EEA22761.1 - 1.5e-11 44.2 14.9 4.8e-11 42.6 14.9 1.9 1 0 0 1 1 1 1 CFEM domain Ilm1 PF10311.9 EEA22762.1 - 2.2e-53 180.3 1.9 2.7e-53 180.0 1.9 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 Choline_transpo PF04515.12 EEA22762.1 - 0.0057 15.9 0.4 0.0098 15.1 0.4 1.3 1 0 0 1 1 1 1 Plasma-membrane choline transporter Prenyltrans PF00432.21 EEA22763.1 - 4.2e-30 103.2 11.9 7.1e-09 35.3 0.1 6.2 6 1 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EEA22763.1 - 0.00016 20.9 0.0 0.087 11.9 0.0 3.1 2 1 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain Pkinase PF00069.25 EEA22764.1 - 7.2e-66 222.2 0.0 1.2e-65 221.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22764.1 - 2e-41 142.0 0.0 3.3e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA22764.1 - 1.7e-09 37.4 0.0 1.5e-08 34.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EEA22764.1 - 3.1e-06 26.4 0.1 3.1e-06 26.4 0.1 2.5 3 0 0 3 3 3 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EEA22764.1 - 0.08 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EEA22764.1 - 0.13 12.1 2.0 0.76 9.6 0.2 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Flp_C PF05202.12 EEA22764.1 - 0.16 11.5 0.2 0.26 10.8 0.2 1.2 1 0 0 1 1 1 0 Recombinase Flp protein Ferlin_C PF16165.5 EEA22764.1 - 0.21 11.5 0.4 0.51 10.3 0.4 1.6 1 0 0 1 1 1 0 Ferlin C-terminus E1-E2_ATPase PF00122.20 EEA22765.1 - 2.2e-52 177.2 6.5 3.6e-51 173.2 2.3 2.6 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EEA22765.1 - 9.8e-47 159.0 7.7 1e-46 159.0 6.2 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EEA22765.1 - 2.8e-22 80.0 0.6 3.1e-21 76.6 0.6 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA22765.1 - 8.9e-19 67.0 0.1 2.3e-18 65.6 0.1 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EEA22765.1 - 4.3e-17 62.0 0.0 8.3e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA22765.1 - 3.9e-08 33.3 1.0 3.7e-06 26.9 0.8 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA22765.1 - 1.7e-06 28.6 0.0 6.3e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Fumarate_red_D PF02313.17 EEA22765.1 - 0.056 13.6 0.9 0.55 10.4 0.1 2.6 2 0 0 2 2 2 0 Fumarate reductase subunit D 14-3-3 PF00244.20 EEA22766.1 - 3.2e-103 344.0 2.0 4.5e-103 343.5 2.0 1.2 1 0 0 1 1 1 1 14-3-3 protein DUF1653 PF07866.11 EEA22766.1 - 0.055 13.8 0.3 7.6 6.9 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1653) eIF3_subunit PF08597.10 EEA22767.1 - 2.3e-73 247.1 35.4 2.5e-73 246.9 35.4 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit PBP_sp32 PF07222.12 EEA22767.1 - 1.4 8.3 11.0 2.7 7.4 11.0 1.5 1 0 0 1 1 1 0 Proacrosin binding protein sp32 VIR_N PF15912.5 EEA22767.1 - 1.5 8.4 14.6 0.3 10.6 10.6 1.7 2 0 0 2 2 2 0 Virilizer, N-terminal Cytomega_UL84 PF06284.11 EEA22767.1 - 2.1 6.7 9.6 3.2 6.1 9.6 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein YL1 PF05764.13 EEA22767.1 - 5.1 7.1 34.4 1.5e+03 -0.9 34.4 2.1 1 1 0 1 1 1 0 YL1 nuclear protein Cupin_8 PF13621.6 EEA22767.1 - 5.2 6.7 9.2 0.53 10.0 4.4 1.7 2 0 0 2 2 2 0 Cupin-like domain CTP_synth_N PF06418.14 EEA22768.1 - 1.5e-121 404.7 0.3 1.9e-121 404.4 0.3 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EEA22768.1 - 1.2e-54 185.0 0.0 2.9e-54 183.7 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EEA22768.1 - 1.1e-06 28.5 0.2 4.3e-06 26.6 0.2 2.0 1 1 0 1 1 1 1 Peptidase C26 CTP_synth_N PF06418.14 EEA22769.1 - 2.1e-93 312.5 0.0 2.7e-93 312.1 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EEA22769.1 - 9.5e-55 185.3 0.0 2.4e-54 184.0 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EEA22769.1 - 9e-07 28.9 0.2 3.6e-06 26.9 0.2 2.0 1 1 0 1 1 1 1 Peptidase C26 Enolase_C PF00113.22 EEA22770.1 - 8.2e-153 507.9 0.0 1.1e-152 507.5 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EEA22770.1 - 1.1e-57 193.8 0.1 2.1e-57 192.9 0.1 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EEA22770.1 - 8e-05 22.3 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EEA22770.1 - 0.017 14.3 0.2 2.4 7.3 0.1 2.9 3 0 0 3 3 3 0 Methylaspartate ammonia-lyase C-terminus AAA PF00004.29 EEA22771.1 - 6e-43 146.4 0.0 1.2e-42 145.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EEA22771.1 - 5.4e-12 45.5 0.2 9.5e-11 41.5 0.0 2.5 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EEA22771.1 - 3.3e-11 42.8 0.1 7.4e-11 41.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EEA22771.1 - 1.7e-07 31.8 0.0 6e-05 23.5 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 EEA22771.1 - 1.5e-06 28.3 0.1 3.8e-05 23.7 0.1 2.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA22771.1 - 2.7e-06 27.6 0.0 9.3e-06 25.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EEA22771.1 - 6.8e-06 25.9 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA22771.1 - 0.00021 21.6 0.1 0.0061 16.8 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EEA22771.1 - 0.00033 19.9 0.0 0.00066 18.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EEA22771.1 - 0.00037 21.1 0.5 0.0026 18.3 0.0 2.4 3 1 0 3 3 2 1 AAA domain AAA_7 PF12775.7 EEA22771.1 - 0.00086 18.9 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EEA22771.1 - 0.0018 17.5 0.3 0.0042 16.3 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain TsaE PF02367.17 EEA22771.1 - 0.0031 17.5 0.1 0.0089 16.0 0.0 1.8 2 0 0 2 2 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EEA22771.1 - 0.0034 16.8 1.0 0.14 11.5 0.0 2.7 3 0 0 3 3 3 1 KaiC AAA_33 PF13671.6 EEA22771.1 - 0.004 17.3 0.0 0.01 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EEA22771.1 - 0.0042 16.7 0.0 0.012 15.2 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain Mg_chelatase PF01078.21 EEA22771.1 - 0.0045 16.4 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA22771.1 - 0.0058 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 EEA22771.1 - 0.0059 16.4 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EEA22771.1 - 0.006 16.6 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EEA22771.1 - 0.0076 16.0 0.1 0.058 13.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EEA22771.1 - 0.0084 15.8 0.0 0.031 14.0 0.0 1.9 1 1 1 2 2 2 1 Sigma-54 interaction domain Thymidylate_kin PF02223.17 EEA22771.1 - 0.01 15.5 0.1 3.8 7.1 0.0 2.6 3 0 0 3 3 2 0 Thymidylate kinase AAA_3 PF07726.11 EEA22771.1 - 0.012 15.4 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EEA22771.1 - 0.042 13.6 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain GAS PF13851.6 EEA22771.1 - 0.046 13.1 4.9 0.036 13.4 1.9 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding AAA_11 PF13086.6 EEA22771.1 - 0.056 13.2 0.4 0.26 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EEA22771.1 - 0.057 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EEA22771.1 - 0.058 13.3 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain DUF3363 PF11843.8 EEA22771.1 - 0.076 12.0 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3363) AAA_28 PF13521.6 EEA22771.1 - 0.088 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EEA22771.1 - 0.094 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA22771.1 - 0.1 12.9 0.1 0.26 11.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain Sec8_exocyst PF04048.14 EEA22771.1 - 0.11 12.4 0.8 0.29 11.0 0.8 1.7 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Zeta_toxin PF06414.12 EEA22771.1 - 0.11 11.7 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 EEA22771.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF16 PF01519.16 EEA22771.1 - 0.2 12.1 2.2 0.59 10.6 2.2 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF16 DHHA1 PF02272.19 EEA22771.1 - 0.35 11.3 3.5 1.1 9.6 0.8 2.8 3 1 1 4 4 2 0 DHHA1 domain Glyco_hydro_47 PF01532.20 EEA22772.1 - 1.3e-168 561.6 0.1 1.6e-168 561.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF1028 PF06267.12 EEA22772.1 - 0.031 14.0 0.0 3.3 7.5 0.0 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF1028) NACHT_sigma PF17106.5 EEA22773.1 - 0.04 14.1 11.6 0.84 9.8 3.1 2.9 2 1 0 2 2 2 0 Sigma domain on NACHT-NTPases Ank_2 PF12796.7 EEA22774.1 - 5.8e-14 52.4 0.1 2.6e-05 24.7 0.1 4.1 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA22774.1 - 7.9e-13 48.7 5.7 1.4e-05 25.5 0.2 5.0 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA22774.1 - 1.2e-10 40.6 8.5 0.58 10.9 0.0 7.1 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 EEA22774.1 - 8e-10 38.8 1.6 0.0041 17.4 0.1 5.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA22774.1 - 7.5e-06 26.2 4.8 0.59 10.7 0.0 6.0 6 0 0 6 6 6 2 Ankyrin repeat p450 PF00067.22 EEA22775.1 - 8.7e-55 186.3 0.3 1.1e-54 186.0 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ank_2 PF12796.7 EEA22776.1 - 8.7e-246 795.3 38.0 1.1e-19 70.7 0.0 15.7 3 2 15 20 20 20 19 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA22776.1 - 2.7e-152 493.3 22.3 1e-12 48.3 0.0 22.1 7 6 14 24 24 24 22 Ankyrin repeats (many copies) Ank PF00023.30 EEA22776.1 - 1.5e-148 477.4 23.9 9.5e-07 29.0 0.0 32.4 31 3 3 34 34 34 28 Ankyrin repeat Ank_3 PF13606.6 EEA22776.1 - 5.3e-145 453.5 16.2 6.4e-05 23.1 0.0 32.0 31 1 1 32 32 32 29 Ankyrin repeat Ank_5 PF13857.6 EEA22776.1 - 1.9e-111 362.7 41.6 1.2e-10 41.4 0.0 24.7 6 3 21 28 28 28 25 Ankyrin repeats (many copies) HET PF06985.11 EEA22776.1 - 2.2e-07 31.3 1.2 2.6e-05 24.6 0.2 2.6 1 1 1 2 2 2 1 Heterokaryon incompatibility protein (HET) VWA_3_C PF18571.1 EEA22776.1 - 0.00094 19.0 22.5 2.7 8.0 0.0 11.3 12 1 1 13 13 13 2 von Willebrand factor type A C-terminal domain DUF5619 PF18505.1 EEA22776.1 - 0.064 13.2 0.2 4.7 7.3 0.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5619) M20_dimer PF07687.14 EEA22777.1 - 1.3e-19 70.1 0.0 2.4e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EEA22777.1 - 9.2e-15 54.9 0.0 3e-14 53.2 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EEA22777.1 - 0.011 15.4 0.0 0.029 14.1 0.0 1.6 1 1 0 1 1 1 0 Peptidase family M28 Secretin_N PF03958.17 EEA22777.1 - 0.027 14.9 0.0 0.14 12.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain HATPase_c PF02518.26 EEA22778.1 - 1.5e-20 73.8 0.0 3.2e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EEA22778.1 - 2.1e-16 60.1 0.6 0.00021 21.4 0.0 3.6 3 0 0 3 3 3 3 Response regulator receiver domain HisKA PF00512.25 EEA22778.1 - 8.7e-06 25.7 0.1 2.2e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EEA22778.1 - 0.062 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NUDE_C PF04880.13 EEA22778.1 - 2.3 8.7 4.3 2.4 8.6 0.3 3.0 2 1 1 3 3 3 0 NUDE protein, C-terminal conserved region EHN PF06441.12 EEA22779.1 - 3.2e-09 37.1 0.2 6.3e-09 36.2 0.2 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus EHN PF06441.12 EEA22780.1 - 3.2e-09 37.1 0.2 6.3e-09 36.2 0.2 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Proteasome PF00227.26 EEA22781.1 - 2.4e-41 141.3 0.0 2.8e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Proteasome PF00227.26 EEA22782.1 - 4.9e-38 130.5 0.0 5.5e-38 130.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Proteasome PF00227.26 EEA22783.1 - 4.3e-32 111.1 0.0 5.4e-32 110.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TUG-UBL1 PF11470.8 EEA22784.1 - 1.2e-24 86.3 0.3 3.6e-24 84.7 0.1 2.0 2 0 0 2 2 2 1 TUG ubiquitin-like domain UBX PF00789.20 EEA22784.1 - 0.00065 19.8 0.0 0.0029 17.8 0.0 2.1 2 0 0 2 2 2 1 UBX domain RBD PF02196.15 EEA22784.1 - 0.06 13.4 0.2 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 Raf-like Ras-binding domain SRP19 PF01922.17 EEA22784.1 - 0.066 14.2 0.1 11 7.0 0.0 3.1 3 0 0 3 3 3 0 SRP19 protein Ribosomal_L36e PF01158.18 EEA22785.1 - 3.5e-40 136.1 5.9 4e-40 136.0 5.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e PBS_linker_poly PF00427.21 EEA22785.1 - 0.0025 17.9 0.2 0.0028 17.7 0.2 1.1 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide MRP-L28 PF09812.9 EEA22785.1 - 0.015 15.5 2.0 0.017 15.3 2.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 NatB_MDM20 PF09797.9 EEA22786.1 - 1.5e-102 343.4 6.1 1.5e-102 343.4 6.1 1.8 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 EEA22786.1 - 0.037 14.5 0.2 0.53 10.8 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1296 PF06972.11 EEA22786.1 - 1.3 9.2 3.9 16 5.7 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1296) zf-C3HC4 PF00097.25 EEA22788.1 - 6.4e-09 35.5 4.6 6.4e-09 35.5 4.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA22788.1 - 4.7e-08 33.2 7.1 4.7e-08 33.2 7.1 2.7 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA22788.1 - 4.2e-07 29.7 6.2 4.2e-07 29.7 6.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA22788.1 - 9.3e-07 28.6 12.2 1.2e-06 28.3 4.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA22788.1 - 1.3e-06 28.4 7.7 1.3e-06 28.4 7.7 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EEA22788.1 - 1.4e-06 28.2 7.0 3.9e-06 26.8 7.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA22788.1 - 4.1e-05 23.5 6.3 4.1e-05 23.5 6.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 EEA22788.1 - 0.00078 19.3 3.1 0.00078 19.3 3.1 2.1 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EEA22788.1 - 0.0027 17.5 4.9 0.0027 17.5 4.9 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EEA22788.1 - 0.0053 16.8 1.6 0.0053 16.8 1.6 2.3 3 0 0 3 3 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 EEA22788.1 - 0.0069 16.4 13.6 0.045 13.8 1.3 2.9 2 1 0 2 2 2 2 Double zinc ribbon Baculo_IE-1 PF05290.11 EEA22788.1 - 0.09 12.7 0.4 0.16 11.9 0.4 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-ribbon_3 PF13248.6 EEA22788.1 - 0.23 10.9 6.0 0.38 10.2 1.6 2.8 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EEA22788.1 - 0.25 10.9 6.1 2.9 7.5 0.3 3.5 2 1 1 3 3 3 0 TFIIB zinc-binding zf-RING_4 PF14570.6 EEA22788.1 - 0.35 10.7 10.2 0.1 12.4 2.1 2.9 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain WD40 PF00400.32 EEA22789.1 - 4e-21 74.9 7.1 5.8e-06 27.0 0.0 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA22789.1 - 0.00019 21.6 0.0 0.0062 16.8 0.0 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA22789.1 - 0.026 13.8 0.0 0.053 12.9 0.0 1.5 1 1 0 1 1 1 0 WD40-like domain DUF885 PF05960.11 EEA22789.1 - 0.059 13.0 0.4 0.091 12.4 0.4 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Proteasome PF00227.26 EEA22790.1 - 6.4e-38 130.2 0.0 7.4e-38 129.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit UCH PF00443.29 EEA22791.1 - 9.5e-25 87.5 0.5 4e-24 85.5 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EEA22791.1 - 1.7e-12 47.4 0.8 3.1e-12 46.6 0.2 1.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EEA22791.1 - 0.001 18.7 0.0 0.016 14.9 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Med3 PF11593.8 EEA22791.1 - 0.61 9.2 5.6 1.1 8.4 5.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal WD40 PF00400.32 EEA22793.1 - 2.6e-54 179.9 8.7 1.1e-06 29.2 0.1 13.2 12 2 0 12 12 12 10 WD domain, G-beta repeat Utp13 PF08625.11 EEA22793.1 - 1.2e-48 164.6 0.2 2e-48 163.9 0.2 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EEA22793.1 - 6.4e-13 48.8 0.6 0.12 12.7 0.0 7.2 6 3 0 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA22793.1 - 0.0012 17.8 0.2 0.15 11.0 0.0 3.9 6 0 0 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein G-patch_2 PF12656.7 EEA22794.1 - 1.5e-24 85.8 0.5 5.8e-24 84.0 0.3 2.2 2 0 0 2 2 2 1 G-patch domain G-patch PF01585.23 EEA22794.1 - 0.00081 19.2 0.3 0.0022 17.8 0.3 1.8 1 0 0 1 1 1 1 G-patch domain Pkinase PF00069.25 EEA22795.1 - 0.0075 15.7 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22795.1 - 0.077 12.3 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase PF00069.25 EEA22796.1 - 1e-52 179.2 0.0 1.3e-52 178.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA22796.1 - 8.2e-21 74.4 0.0 3e-20 72.6 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA22796.1 - 4.9e-09 35.9 0.0 8e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA22796.1 - 0.0008 18.3 0.0 0.0012 17.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EEA22796.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EEA22796.1 - 0.073 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase NmrA PF05368.13 EEA22797.1 - 5.1e-17 62.2 0.2 6.8e-17 61.8 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA22797.1 - 6.3e-15 55.5 0.2 1e-14 54.9 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA22797.1 - 4.2e-06 26.4 0.0 6.9e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EEA22797.1 - 0.00085 19.4 0.1 0.0016 18.6 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EEA22797.1 - 0.0034 17.8 0.3 0.0065 16.9 0.3 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EEA22797.1 - 0.009 15.0 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EEA22797.1 - 0.013 14.7 0.2 0.018 14.2 0.2 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Shikimate_DH PF01488.20 EEA22797.1 - 0.031 14.3 0.1 0.052 13.6 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EEA22797.1 - 0.06 13.9 1.8 0.14 12.8 1.4 1.9 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent KR PF08659.10 EEA22797.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 KR domain NAD_binding_4 PF07993.12 EEA22797.1 - 0.11 11.7 0.1 0.23 10.6 0.1 1.6 1 1 0 1 1 1 0 Male sterility protein DUF1348 PF07080.11 EEA22797.1 - 0.11 12.4 0.3 0.2 11.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1348) Myb_DNA-bind_6 PF13921.6 EEA22798.1 - 1.7e-16 60.2 1.0 4.5e-16 58.8 0.2 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain HSA PF07529.13 EEA22798.1 - 1.3e-13 51.0 0.9 1.3e-13 51.0 0.9 4.3 4 0 0 4 4 4 1 HSA Myb_DNA-binding PF00249.31 EEA22798.1 - 0.00024 21.2 1.8 0.00066 19.8 0.2 2.6 3 0 0 3 3 3 1 Myb-like DNA-binding domain WD40 PF00400.32 EEA22799.1 - 1.1e-09 38.7 2.0 0.16 12.9 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat eIF2_C PF09173.11 EEA22800.1 - 1.3e-34 118.3 0.5 2.8e-34 117.2 0.5 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EEA22800.1 - 3.5e-24 85.4 0.5 1.6e-23 83.2 0.5 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EEA22800.1 - 1.6e-11 44.4 0.1 3.8e-11 43.2 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA22800.1 - 0.0055 16.8 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA22800.1 - 0.007 16.3 0.0 0.046 13.6 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EEA22800.1 - 0.094 11.9 0.1 0.27 10.4 0.0 1.6 2 0 0 2 2 2 0 G-protein alpha subunit Peptidase_S49_N PF08496.10 EEA22801.1 - 1.7 8.7 7.0 3.7 7.6 1.8 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Peptidase_M48_N PF16491.5 EEA22802.1 - 7.3e-66 221.5 9.3 7.3e-66 221.5 9.3 1.8 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EEA22802.1 - 8.6e-45 152.9 0.1 1.6e-44 152.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M48 DUF4538 PF15061.6 EEA22802.1 - 0.03 14.0 1.7 0.072 12.8 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Peptidase_M56 PF05569.11 EEA22802.1 - 0.037 13.2 3.3 0.21 10.7 3.3 1.9 1 1 0 1 1 1 0 BlaR1 peptidase M56 Peptidase_M48_N PF16491.5 EEA22803.1 - 4.8e-66 222.1 9.3 4.8e-66 222.1 9.3 1.8 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EEA22803.1 - 6.6e-30 104.3 0.0 1.3e-29 103.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M48 DUF4538 PF15061.6 EEA22803.1 - 0.023 14.4 1.7 0.058 13.1 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Peptidase_M56 PF05569.11 EEA22803.1 - 0.026 13.7 3.1 0.097 11.8 3.1 1.8 1 1 0 1 1 1 0 BlaR1 peptidase M56 Peptidase_M16_C PF05193.21 EEA22804.1 - 8.7e-18 65.0 0.0 8.7e-16 58.5 0.0 2.8 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA22804.1 - 3.8e-05 23.7 0.0 0.00013 22.0 0.0 1.9 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Sporozoite_P67 PF05642.11 EEA22804.1 - 3.4 5.7 7.2 4.7 5.2 7.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PPP4R2 PF09184.11 EEA22804.1 - 3.6 7.1 10.8 5.7 6.5 10.8 1.3 1 0 0 1 1 1 0 PPP4R2 Zw10 PF06248.13 EEA22805.1 - 3.4e-09 35.8 0.3 8.9e-09 34.4 0.3 1.6 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 EEA22805.1 - 1.8e-07 31.1 0.3 1.8e-07 31.1 0.3 1.9 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal DUF948 PF06103.11 EEA22805.1 - 0.029 14.6 0.5 12 6.2 0.1 3.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.32 EEA22806.1 - 2.4e-19 69.3 18.3 1.1e-06 29.2 0.6 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat NLE PF08154.12 EEA22806.1 - 4.5e-17 62.3 0.0 9.2e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 EEA22806.1 - 7.6e-05 21.5 5.0 0.0038 15.9 0.6 2.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ribosomal_S13 PF00416.22 EEA22807.1 - 2.1e-20 73.4 0.6 3.5e-18 66.2 0.6 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 Pro_isomerase PF00160.21 EEA22808.1 - 2.4e-48 164.4 0.2 3.2e-48 164.0 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3149 PF11346.8 EEA22808.1 - 0.8 9.4 3.8 1.2 8.8 2.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) Pro_isomerase PF00160.21 EEA22809.1 - 1.1e-48 165.4 0.2 1.4e-48 165.2 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DEAD PF00270.29 EEA22810.1 - 4.3e-49 166.7 0.0 1.1e-48 165.3 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA22810.1 - 1.5e-31 109.1 0.0 3.9e-31 107.7 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA22810.1 - 0.0022 18.0 0.0 0.0039 17.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EEA22810.1 - 0.046 13.1 0.1 0.079 12.3 0.1 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 EEA22810.1 - 0.17 11.1 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase INSIG PF07281.12 EEA22812.1 - 3.5e-67 226.1 1.7 4.5e-67 225.8 1.7 1.1 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) AICARFT_IMPCHas PF01808.18 EEA22813.1 - 8.7e-93 311.0 0.0 1.8e-92 310.0 0.0 1.5 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EEA22813.1 - 2.9e-25 88.3 0.0 5.4e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain AICARFT_IMPCHas PF01808.18 EEA22814.1 - 8.7e-93 311.0 0.0 1.8e-92 310.0 0.0 1.5 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EEA22814.1 - 2.9e-25 88.3 0.0 5.3e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain DUF3425 PF11905.8 EEA22815.1 - 8.7e-05 22.5 0.4 0.00053 19.9 0.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) Avian_gp85 PF03708.14 EEA22815.1 - 0.091 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Avian retrovirus envelope protein, gp85 DUF5588 PF17826.1 EEA22815.1 - 0.12 11.3 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5588) AATase PF07247.12 EEA22816.1 - 7.4e-21 74.3 0.0 1.6e-20 73.2 0.0 1.4 2 0 0 2 2 2 1 Alcohol acetyltransferase Clathrin PF00637.20 EEA22817.1 - 1.7e-198 650.4 44.4 1.5e-32 112.5 0.4 7.5 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 EEA22817.1 - 3e-37 125.1 0.5 8.1e-07 29.1 0.0 6.7 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin_H_link PF13838.6 EEA22817.1 - 9.4e-33 111.9 1.5 3.5e-32 110.1 0.3 2.8 2 0 0 2 2 2 1 Clathrin-H-link TPR_8 PF13181.6 EEA22817.1 - 0.00077 19.5 3.6 0.38 11.1 0.0 5.2 5 0 0 5 5 3 1 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EEA22817.1 - 0.0054 15.8 8.4 0.04 13.0 0.2 4.1 4 0 0 4 4 4 1 Coatomer WD associated region TPR_7 PF13176.6 EEA22817.1 - 0.0055 16.6 5.6 26 5.1 0.0 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat VapB_antitoxin PF09957.9 EEA22817.1 - 0.014 15.3 0.1 0.075 13.0 0.0 2.3 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB TPR_2 PF07719.17 EEA22817.1 - 0.017 15.2 4.2 7.8 6.9 0.1 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA22817.1 - 0.085 12.7 3.4 6.6 6.7 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Utp13 PF08625.11 EEA22817.1 - 0.15 12.0 6.2 6.6 6.6 0.0 4.8 4 1 0 4 4 4 0 Utp13 specific WD40 associated domain TPR_14 PF13428.6 EEA22817.1 - 0.15 12.9 12.0 49 5.1 0.0 8.0 11 1 0 11 11 6 0 Tetratricopeptide repeat Vps39_1 PF10366.9 EEA22817.1 - 0.2 11.9 17.2 8.6 6.7 0.0 7.0 6 2 1 7 7 6 0 Vacuolar sorting protein 39 domain 1 DUF1400 PF07176.11 EEA22817.1 - 0.21 11.9 6.7 10 6.4 0.0 4.9 4 0 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1400) Rop PF01815.16 EEA22817.1 - 1.1 9.2 3.3 0.83 9.6 0.1 2.6 3 0 0 3 3 2 0 Rop protein TPR_12 PF13424.6 EEA22817.1 - 2.3 8.5 8.6 38 4.7 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat CPSase_L_D2 PF02786.17 EEA22818.1 - 4.9e-81 271.3 0.1 7.7e-81 270.6 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EEA22818.1 - 7.9e-70 234.6 0.0 1.3e-69 233.9 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EEA22818.1 - 6e-39 133.0 0.0 1.2e-38 132.0 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EEA22818.1 - 2.1e-30 105.0 0.0 8.9e-30 103.0 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EEA22818.1 - 3.3e-27 95.7 0.0 5.8e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EEA22818.1 - 9.7e-18 63.8 4.7 2e-17 62.8 3.0 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EEA22818.1 - 5.1e-11 42.2 1.6 3.4e-07 30.0 0.1 3.2 2 1 1 3 3 3 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EEA22818.1 - 4.5e-10 39.4 0.0 8.9e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EEA22818.1 - 6.3e-07 29.1 0.0 1.3e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EEA22818.1 - 1.7e-05 24.9 0.0 3.5e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EEA22818.1 - 3.8e-05 23.4 0.0 7.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_D23 PF16576.5 EEA22818.1 - 0.00013 21.2 0.1 0.0033 16.7 0.0 2.3 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 EEA22818.1 - 0.0048 17.6 0.5 3.5 8.4 0.0 3.6 4 0 0 4 4 4 1 HlyD family secretion protein GARS_A PF01071.19 EEA22818.1 - 0.0071 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.6 EEA22818.1 - 0.0097 15.5 0.0 0.026 14.1 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EEA22818.1 - 0.054 12.7 0.0 0.26 10.5 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp DUF2118 PF09891.9 EEA22818.1 - 0.058 13.3 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) COesterase PF00135.28 EEA22819.1 - 6.9e-49 167.1 0.0 1e-48 166.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA22819.1 - 0.0024 17.8 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Caskin1-CID PF16600.5 EEA22820.1 - 0.0038 17.8 4.7 0.0077 16.8 4.7 1.5 1 0 0 1 1 1 1 Caskin1 CASK-interaction domain DUF4716 PF15837.5 EEA22820.1 - 0.086 12.9 3.4 0.11 12.6 2.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4716) Ribosomal_L5_C PF00673.21 EEA22821.1 - 2.8e-22 78.7 0.0 4.1e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EEA22821.1 - 2.4e-20 72.6 0.0 7.4e-20 71.0 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 EEA22821.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain LSM PF01423.22 EEA22822.1 - 6.3e-20 70.6 0.0 7.6e-20 70.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain MPC PF03650.13 EEA22823.1 - 1.1e-35 122.1 0.0 1.2e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Aa_trans PF01490.18 EEA22824.1 - 7.9e-84 281.7 32.5 9.8e-84 281.4 32.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease PF00324.21 EEA22825.1 - 2.8e-58 197.7 37.6 3.5e-58 197.4 37.6 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EEA22825.1 - 8.9e-20 71.1 3.8 1.4e-07 31.0 0.0 3.5 4 0 0 4 4 4 3 Solute carrier family 12 GHMP_kinases_N PF00288.26 EEA22826.1 - 2.9e-16 59.5 1.4 2.5e-15 56.5 0.0 2.5 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EEA22826.1 - 4.8e-08 33.2 0.0 1.3e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EEA22826.1 - 0.00044 19.7 0.0 0.0011 18.4 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature Clr2 PF10383.9 EEA22826.1 - 0.24 12.2 1.3 0.56 11.0 1.3 1.6 1 0 0 1 1 1 0 Transcription-silencing protein Clr2 MAGE_N PF12440.8 EEA22826.1 - 1.2 9.9 14.2 3.2 8.5 14.2 1.7 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal MGC-24 PF05283.11 EEA22826.1 - 3.5 8.1 7.2 6.6 7.2 7.2 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Fungal_trans_2 PF11951.8 EEA22827.1 - 1.5e-30 106.3 1.1 1.3e-20 73.6 0.4 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA22827.1 - 3.2e-07 30.4 9.5 5e-07 29.7 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sulfatase PF00884.23 EEA22829.1 - 1.2e-20 74.2 0.3 1.9e-20 73.5 0.3 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EEA22829.1 - 9.6e-07 28.7 0.0 1.9e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EEA22829.1 - 2.7e-05 23.0 0.0 5.6e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4287 PF14117.6 EEA22829.1 - 0.058 13.5 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) PPTA PF01239.22 EEA22830.1 - 1.4e-37 126.3 14.4 1.2e-08 34.3 0.6 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat PALP PF00291.25 EEA22831.1 - 1.7e-50 172.1 0.1 5.9e-50 170.3 0.1 1.7 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme tRNA-synt_1g PF09334.11 EEA22832.1 - 4.3e-97 325.3 2.8 6.8e-96 321.4 2.8 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EEA22832.1 - 8.9e-25 87.0 1.2 4.1e-11 41.8 0.1 3.1 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EEA22832.1 - 1.4e-11 44.3 0.1 2.1e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EEA22832.1 - 2.3e-05 24.4 0.0 5.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA HTH_AraC PF00165.23 EEA22832.1 - 0.15 12.2 0.0 34 4.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family NTF2 PF02136.20 EEA22833.1 - 4.3e-08 33.8 0.0 5.8e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 EEA22833.1 - 9.7e-06 25.6 0.2 6.5e-05 22.9 0.2 1.9 1 1 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 Ish1 PF10281.9 EEA22834.1 - 7.3e-06 26.2 0.1 1.3e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein SAP PF02037.27 EEA22834.1 - 0.015 15.0 0.2 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 SAP domain MFAP1 PF06991.11 EEA22834.1 - 0.046 13.6 0.5 0.05 13.4 0.5 1.1 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing COX4 PF02936.14 EEA22834.1 - 0.087 12.8 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV Ribosomal_L38e PF01781.18 EEA22835.1 - 2.7e-32 110.7 3.1 3.1e-32 110.5 3.1 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Acetyltransf_3 PF13302.7 EEA22836.1 - 3e-20 73.3 0.0 3.8e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA22836.1 - 0.00075 19.4 0.0 0.15 12.0 0.0 3.0 3 0 0 3 3 3 1 FR47-like protein Cwf_Cwc_15 PF04889.12 EEA22836.1 - 0.18 11.5 2.3 0.25 11.1 2.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_E_B PF04042.16 EEA22837.1 - 4.7e-46 156.8 0.0 6.2e-46 156.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EEA22837.1 - 5.1e-39 133.4 0.0 7.6e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain NMO PF03060.15 EEA22838.1 - 1.4e-57 195.5 0.3 2.1e-57 195.0 0.3 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EEA22838.1 - 1.9e-07 30.4 0.2 9.3e-06 24.9 0.2 2.3 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EEA22838.1 - 0.0016 17.5 3.6 0.0034 16.5 2.9 1.8 2 0 0 2 2 2 1 FMN-dependent dehydrogenase ATP-synt_I PF03899.15 EEA22838.1 - 0.014 15.7 0.5 0.028 14.8 0.5 1.4 1 0 0 1 1 1 0 ATP synthase I chain NAD_binding_2 PF03446.15 EEA22838.1 - 0.026 14.7 0.0 0.33 11.1 0.0 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Radial_spoke_3 PF06098.11 EEA22838.1 - 0.036 13.4 0.1 0.05 12.9 0.1 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 Glu_synthase PF01645.17 EEA22838.1 - 0.19 10.8 1.5 0.33 10.0 1.5 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase Taxilin PF09728.9 EEA22839.1 - 6e-93 311.4 58.1 6e-93 311.4 58.1 1.8 1 1 1 2 2 2 1 Myosin-like coiled-coil protein ERM PF00769.19 EEA22839.1 - 0.007 16.2 17.2 0.007 16.2 17.2 3.8 2 1 2 4 4 4 1 Ezrin/radixin/moesin family DUF3675 PF12428.8 EEA22839.1 - 0.3 11.6 4.3 6.4 7.4 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) DUF3584 PF12128.8 EEA22839.1 - 2.6 5.5 47.8 3.9 4.8 46.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) GOLGA2L5 PF15070.6 EEA22839.1 - 5.6 5.5 43.7 1.2 7.8 34.8 2.2 1 1 1 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 zf-C4H2 PF10146.9 EEA22839.1 - 8.2 6.7 37.6 0.69 10.2 7.7 3.3 2 1 1 3 3 3 0 Zinc finger-containing protein M16C_assoc PF08367.11 EEA22840.1 - 1.8e-70 236.9 0.0 2.8e-70 236.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EEA22840.1 - 1.1e-20 74.4 0.0 3.3e-13 50.0 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA22840.1 - 3.6e-11 43.3 0.1 6.4e-10 39.2 0.0 2.9 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) YbaJ PF10757.9 EEA22840.1 - 1 9.9 2.6 2 9.0 0.1 2.7 3 0 0 3 3 3 0 Biofilm formation regulator YbaJ adh_short PF00106.25 EEA22841.1 - 1.8e-22 79.8 0.0 2.4e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22841.1 - 8.8e-17 61.4 0.0 1.1e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22841.1 - 0.01 15.8 0.0 0.02 14.8 0.0 1.5 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EEA22842.1 - 1.4e-22 80.2 0.0 1.8e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA22842.1 - 6.6e-17 61.9 0.0 8.5e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA22842.1 - 0.0077 16.2 0.0 0.016 15.1 0.0 1.5 1 1 0 1 1 1 1 KR domain MRPL52 PF18699.1 EEA22843.1 - 2 8.6 5.1 0.45 10.7 1.2 1.9 2 0 0 2 2 2 0 Mitoribosomal protein mL52 Methyltransf_16 PF10294.9 EEA22844.1 - 9.1e-53 178.6 0.0 1.2e-52 178.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EEA22844.1 - 9.9e-05 22.2 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA22844.1 - 0.00063 20.4 0.0 0.0015 19.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA22844.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Orn_Arg_deC_N PF02784.16 EEA22845.1 - 1.3e-80 270.4 0.0 1.7e-80 270.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EEA22845.1 - 2.4e-18 66.2 0.0 4e-18 65.4 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EEA22845.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel cobW PF02492.19 EEA22846.1 - 2.6e-42 144.4 0.0 3.9e-42 143.8 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EEA22846.1 - 0.0043 17.3 0.2 0.047 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 EEA22846.1 - 0.0058 16.5 0.0 0.028 14.3 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B CobW_C PF07683.14 EEA22846.1 - 0.01 15.7 0.0 0.51 10.3 0.0 2.6 2 0 0 2 2 2 0 Cobalamin synthesis protein cobW C-terminal domain AAA_29 PF13555.6 EEA22846.1 - 0.026 14.3 0.1 0.39 10.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Pox_A32 PF04665.12 EEA22846.1 - 0.03 13.8 0.1 0.16 11.4 0.0 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_16 PF13191.6 EEA22846.1 - 0.099 13.0 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Brucella_OMP2 PF05244.11 EEA22847.1 - 0.04 13.3 0.8 0.05 13.0 0.8 1.1 1 0 0 1 1 1 0 Brucella outer membrane protein 2 Brucella_OMP2 PF05244.11 EEA22848.1 - 0.04 13.3 0.8 0.05 13.0 0.8 1.1 1 0 0 1 1 1 0 Brucella outer membrane protein 2 SH3_9 PF14604.6 EEA22849.1 - 0.029 14.2 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Variant SH3 domain Mitofilin PF09731.9 EEA22851.1 - 4.4e-161 537.9 32.7 2.3e-130 436.4 27.7 2.0 1 1 1 2 2 2 2 Mitochondrial inner membrane protein Cullin PF00888.22 EEA22851.1 - 0.0013 17.5 4.7 0.0019 16.9 4.7 1.2 1 0 0 1 1 1 1 Cullin family Cas_DxTHG PF09455.10 EEA22851.1 - 0.022 14.3 5.3 0.037 13.6 5.3 1.4 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Focal_AT PF03623.13 EEA22851.1 - 0.047 13.7 0.4 0.047 13.7 0.4 2.6 2 1 1 3 3 3 0 Focal adhesion targeting region Lys-AminoMut_A PF09043.11 EEA22851.1 - 0.049 12.1 5.0 0.03 12.8 3.1 1.6 1 1 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit Ribosomal_L20 PF00453.18 EEA22851.1 - 0.31 11.1 4.0 0.82 9.8 4.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L20 tRNA_anti-like PF12869.7 EEA22851.1 - 5.2 6.7 6.9 0.85 9.2 1.8 2.2 2 0 0 2 2 2 0 tRNA_anti-like NAM-associated PF14303.6 EEA22851.1 - 6.4 7.5 16.2 28 5.4 9.4 2.9 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain HisK_N PF09385.10 EEA22851.1 - 6.4 6.8 6.7 7.6 6.5 3.0 2.9 2 1 0 3 3 3 0 Histidine kinase N terminal Ras PF00071.22 EEA22852.1 - 1.5e-59 200.2 0.4 1.8e-59 200.0 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA22852.1 - 1.3e-36 125.5 0.2 2.4e-36 124.6 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA22852.1 - 1.1e-14 54.2 0.0 1.4e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA22852.1 - 2.5e-07 30.5 0.0 3.5e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EEA22852.1 - 5.9e-07 29.1 0.0 7.1e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA22852.1 - 8.6e-07 29.0 0.0 1.4e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA22852.1 - 2.1e-05 24.5 1.6 0.12 12.3 0.3 2.4 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EEA22852.1 - 0.013 15.9 0.1 0.025 15.0 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EEA22852.1 - 0.051 13.9 0.1 2.7 8.3 0.0 2.3 1 1 1 2 2 2 0 AAA domain SRPRB PF09439.10 EEA22852.1 - 0.059 12.8 0.1 0.11 12.0 0.1 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GbpA_2 PF18416.1 EEA22852.1 - 0.11 12.8 0.8 5.5 7.3 0.0 2.3 1 1 1 2 2 2 0 N-acetylglucosamine binding protein domain 2 Amidase02_C PF12123.8 EEA22852.1 - 0.13 11.9 0.0 4.7 7.0 0.0 2.4 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase Syja_N PF02383.18 EEA22853.1 - 2.7e-91 306.2 0.1 3.6e-91 305.8 0.1 1.1 1 0 0 1 1 1 1 SacI homology domain Mur_ligase_M PF08245.12 EEA22854.1 - 2.9e-05 24.1 0.4 0.00048 20.2 0.4 2.7 1 1 0 1 1 1 1 Mur ligase middle domain NMT_C PF02799.15 EEA22855.1 - 1.5e-88 295.8 0.0 2.6e-88 295.0 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EEA22855.1 - 8.3e-75 250.0 0.2 9.5e-74 246.6 0.0 2.1 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EEA22855.1 - 7.8e-06 26.0 0.1 0.00026 21.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA22855.1 - 0.00067 19.9 0.0 0.0015 18.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family NTP_transf_9 PF04248.12 EEA22855.1 - 0.012 15.5 0.1 0.039 13.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF427) DUF5024 PF16427.5 EEA22855.1 - 0.035 14.4 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5024) Acetyltransf_10 PF13673.7 EEA22855.1 - 0.075 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TLD PF07534.16 EEA22856.1 - 6.8e-19 68.5 0.0 1.5e-18 67.4 0.0 1.6 1 0 0 1 1 1 1 TLD DUF1773 PF08593.10 EEA22856.1 - 0.062 14.3 1.4 0.25 12.4 1.2 2.2 2 1 0 2 2 2 0 Domain of unknown function Abhydrolase_6 PF12697.7 EEA22858.1 - 7.6e-08 33.2 0.0 1.1e-07 32.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA22858.1 - 2.8e-05 23.5 0.0 0.00011 21.5 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA22858.1 - 0.0016 18.1 0.1 0.0077 15.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EEA22858.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold GTP_EFTU PF00009.27 EEA22859.1 - 3.2e-57 193.2 0.1 5.2e-57 192.5 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EEA22859.1 - 4.6e-34 116.3 0.0 1e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EEA22859.1 - 5.3e-34 116.6 0.0 1e-33 115.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EEA22859.1 - 2e-22 79.0 0.0 4.3e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EEA22859.1 - 3.9e-13 49.6 0.1 8.5e-13 48.5 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EEA22859.1 - 7.3e-07 29.1 0.1 2.2e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain ATP_bind_1 PF03029.17 EEA22859.1 - 0.014 15.2 0.1 0.043 13.6 0.1 1.9 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF442 PF04273.13 EEA22859.1 - 0.067 13.3 0.0 0.92 9.6 0.0 2.7 2 0 0 2 2 2 0 Putative phosphatase (DUF442) MMR_HSR1 PF01926.23 EEA22859.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ribosomal_L36 PF00444.18 EEA22860.1 - 1.3e-20 73.3 9.4 2e-20 72.7 9.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 PALP PF00291.25 EEA22861.1 - 2e-77 260.5 0.3 2.6e-77 260.2 0.3 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EEA22861.1 - 3.1e-44 148.7 0.0 8.9e-24 83.1 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Zn_clus PF00172.18 EEA22862.1 - 3.8e-08 33.3 11.2 6.9e-08 32.5 11.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HIG_1_N PF04588.13 EEA22863.1 - 8.3e-25 86.8 0.1 1.2e-24 86.2 0.1 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region MAS20 PF02064.15 EEA22863.1 - 0.0073 16.4 1.7 0.0073 16.4 1.7 1.8 2 0 0 2 2 2 1 MAS20 protein import receptor DUF2514 PF10721.9 EEA22863.1 - 0.013 15.6 4.4 0.019 15.0 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) SprA-related PF12118.8 EEA22863.1 - 0.061 12.5 3.6 0.091 11.9 3.6 1.2 1 0 0 1 1 1 0 SprA-related family ADP_ribosyl_GH PF03747.14 EEA22863.1 - 0.14 11.9 0.2 0.18 11.5 0.2 1.2 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase HIG_1_N PF04588.13 EEA22864.1 - 7.5e-25 86.9 0.1 1.1e-24 86.4 0.1 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region MAS20 PF02064.15 EEA22864.1 - 0.0065 16.6 1.7 0.0065 16.6 1.7 1.8 2 0 0 2 2 2 1 MAS20 protein import receptor DUF2514 PF10721.9 EEA22864.1 - 0.013 15.6 4.4 0.017 15.2 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) SprA-related PF12118.8 EEA22864.1 - 0.043 13.0 3.3 0.061 12.5 3.3 1.2 1 0 0 1 1 1 0 SprA-related family ADP_ribosyl_GH PF03747.14 EEA22864.1 - 0.12 12.1 0.2 0.16 11.7 0.2 1.2 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase TMEM171 PF15471.6 EEA22865.1 - 0.0073 15.3 0.4 0.012 14.6 0.4 1.2 1 0 0 1 1 1 1 Transmembrane protein family 171 DUF4597 PF15366.6 EEA22865.1 - 0.087 12.6 0.9 0.21 11.4 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) Memo PF01875.17 EEA22867.1 - 6e-64 215.8 0.0 7e-64 215.6 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein LSM PF01423.22 EEA22869.1 - 6.5e-08 32.2 0.0 8.8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA22869.1 - 0.00024 21.2 0.0 0.00033 20.7 0.0 1.5 1 1 0 1 1 1 1 Ataxin 2 SM domain Metallophos PF00149.28 EEA22870.1 - 1.5e-37 130.1 0.1 2.3e-37 129.5 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA22870.1 - 3.3e-16 59.5 0.1 6.2e-16 58.6 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain SOG2 PF10428.9 EEA22870.1 - 0.3 10.2 7.0 0.39 9.9 7.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein WD40 PF00400.32 EEA22871.1 - 4.3e-12 46.3 5.1 0.15 13.0 0.0 8.7 10 0 0 10 10 10 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA22871.1 - 7.7e-08 32.5 0.0 0.021 15.1 0.0 5.9 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EEA22871.1 - 0.0031 17.1 0.6 0.031 13.8 0.6 2.5 1 1 0 1 1 1 1 PQQ-like domain Milton PF12448.8 EEA22871.1 - 0.069 13.3 0.0 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 Kinesin associated protein Cyclin_N PF00134.23 EEA22872.1 - 4.3e-36 123.5 0.4 2.1e-35 121.2 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA22872.1 - 5.7e-12 45.8 0.8 1.8e-11 44.2 0.2 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain Abhydrolase_3 PF07859.13 EEA22873.1 - 1.1e-43 149.6 0.0 1.4e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA22873.1 - 2.1e-06 28.5 0.6 3.3e-06 27.9 0.6 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.28 EEA22873.1 - 1.2e-05 24.4 0.0 2.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family AXE1 PF05448.12 EEA22873.1 - 0.19 10.4 0.8 1.1 7.9 0.0 2.0 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Esterase_phd PF10503.9 EEA22873.1 - 0.4 10.1 3.1 5.2 6.5 2.3 2.5 2 1 0 2 2 2 0 Esterase PHB depolymerase Glyco_transf_34 PF05637.12 EEA22874.1 - 4.7e-10 39.6 0.0 2.5e-05 24.2 0.0 2.2 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family DUF1045 PF06299.12 EEA22874.1 - 0.29 11.1 2.0 7.8 6.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1045) FmdA_AmdA PF03069.15 EEA22875.1 - 1.8e-55 188.3 0.0 2.8e-31 108.7 0.0 2.0 1 1 1 2 2 2 2 Acetamidase/Formamidase family UvrD_C PF13361.6 EEA22876.1 - 7.6e-61 206.4 0.0 1.6e-56 192.2 0.0 2.8 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 EEA22876.1 - 1.3e-60 205.6 0.5 3.2e-59 201.0 0.5 2.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EEA22876.1 - 1.4e-29 103.4 0.0 3e-29 102.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EEA22876.1 - 1.1e-14 54.0 0.8 2.6e-14 52.8 0.1 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EEA22876.1 - 7.6e-07 29.0 0.0 0.0015 18.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 EEA22876.1 - 5.8e-05 22.8 0.0 0.0013 18.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EEA22876.1 - 0.0017 18.2 0.4 0.0085 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA22876.1 - 0.084 13.1 0.5 2.9 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain zf-MYND PF01753.18 EEA22877.1 - 3e-12 46.4 18.0 5.4e-12 45.6 18.0 1.4 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EEA22877.1 - 0.058 13.7 16.2 0.092 13.1 14.9 2.1 2 1 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding NCD3G PF07562.14 EEA22877.1 - 0.73 9.9 10.8 4.3 7.4 0.7 2.4 1 1 1 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Rhodanese_C PF12368.8 EEA22877.1 - 1.7 9.1 11.0 3.2 8.2 11.0 1.4 1 0 0 1 1 1 0 Rhodanase C-terminal Ank_2 PF12796.7 EEA22878.1 - 1.4e-69 230.7 0.3 2.4e-15 56.9 0.0 7.8 2 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA22878.1 - 1.9e-47 153.7 2.1 0.00027 21.2 0.0 13.9 14 0 0 14 14 14 7 Ankyrin repeat Ank PF00023.30 EEA22878.1 - 1.8e-45 151.4 4.1 0.00042 20.6 0.0 13.6 13 0 0 13 13 13 9 Ankyrin repeat Ank_4 PF13637.6 EEA22878.1 - 5.1e-44 148.1 7.5 2.2e-07 31.3 0.2 10.4 3 3 9 12 12 12 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA22878.1 - 1.6e-43 146.1 6.2 3.8e-07 30.3 0.0 11.0 4 2 7 11 11 11 8 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 EEA22878.1 - 6.3e-13 48.5 0.4 1.2e-12 47.6 0.4 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 EEA22878.1 - 1.7e-06 28.1 0.0 3.6e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA22878.1 - 0.0056 17.1 0.0 0.026 14.9 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA22878.1 - 0.012 15.9 0.0 0.068 13.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain Glyco_hydro_3_C PF01915.22 EEA22879.1 - 6.4e-55 186.3 0.1 1.3e-54 185.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA22879.1 - 2.7e-40 138.7 0.0 4.2e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA22879.1 - 7.7e-27 93.2 0.0 1.5e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CBM_1 PF00734.18 EEA22879.1 - 8.3e-12 44.9 17.2 8.3e-12 44.9 17.2 3.2 3 0 0 3 3 3 1 Fungal cellulose binding domain Toxin_7 PF05980.12 EEA22879.1 - 0.15 12.3 4.4 0.36 11.1 4.4 1.6 1 0 0 1 1 1 0 Toxin 7 Tom37 PF10568.9 EEA22880.1 - 2.8e-40 137.5 0.2 5.1e-40 136.7 0.2 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EEA22880.1 - 3.6e-13 49.1 0.3 2.6e-11 43.1 0.0 3.4 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EEA22880.1 - 5.2e-05 23.9 0.0 0.00011 22.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 EEA22880.1 - 0.00021 21.3 0.0 0.0012 18.8 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Zip PF02535.22 EEA22881.1 - 5.2e-67 226.4 5.7 5.9e-67 226.3 5.7 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Sugar_tr PF00083.24 EEA22882.1 - 2.3e-52 178.4 27.8 1.5e-27 96.6 7.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EEA22882.1 - 1.3e-16 60.5 36.9 9.7e-10 37.9 12.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA22882.1 - 0.0055 15.3 24.0 0.25 9.8 0.8 3.8 3 1 1 4 4 4 3 MFS/sugar transport protein TRI12 PF06609.13 EEA22882.1 - 0.48 8.8 14.3 0.12 10.7 5.2 2.6 2 1 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) LIP PF03583.14 EEA22883.1 - 2.9e-54 184.3 0.6 4.2e-54 183.8 0.6 1.2 1 0 0 1 1 1 1 Secretory lipase PP2C PF00481.21 EEA22884.1 - 3.5e-40 138.3 0.0 4e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EEA22884.1 - 1.4e-05 24.8 0.0 0.00036 20.2 0.0 2.8 1 1 1 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 EEA22884.1 - 0.00013 21.9 0.0 0.091 12.7 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Cyt-b5 PF00173.28 EEA22885.1 - 4.3e-14 52.4 0.0 6.2e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FKBP_C PF00254.28 EEA22886.1 - 5.9e-34 116.3 0.0 7.4e-34 116.0 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pex24p PF06398.11 EEA22888.1 - 6.1e-98 328.2 0.2 9.4e-98 327.5 0.2 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Glyco_trans_2_3 PF13632.6 EEA22888.1 - 3.4e-14 53.2 0.3 3.4e-14 53.2 0.3 2.7 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EEA22888.1 - 1.7e-13 50.8 0.0 2.7e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EEA22888.1 - 1.3e-12 48.1 0.0 2.4e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EEA22888.1 - 5e-08 32.6 0.0 8.7e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cellulose_synt PF03552.14 EEA22888.1 - 2.5e-06 26.3 0.3 0.014 13.9 0.1 2.4 2 0 0 2 2 2 2 Cellulose synthase Hepar_II_III PF07940.13 EEA22889.1 - 2.6e-05 24.0 0.3 5.6e-05 22.9 0.3 1.5 1 0 0 1 1 1 1 Heparinase II/III-like protein DUF1929 PF09118.11 EEA22890.1 - 1.8e-20 73.0 0.0 4e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Glyoxal_oxid_N PF07250.11 EEA22890.1 - 2.2e-06 27.0 0.3 0.00016 21.0 0.2 2.5 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus Kelch_6 PF13964.6 EEA22890.1 - 6.1e-06 26.3 8.7 0.013 15.7 0.0 4.9 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EEA22890.1 - 0.0042 16.6 6.1 0.0058 16.2 0.3 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 EEA22890.1 - 0.0069 16.4 7.4 14 5.8 0.0 5.1 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EEA22890.1 - 0.031 14.3 1.1 5.6 7.1 0.2 4.3 4 1 0 4 4 4 0 Kelch motif DUF1249 PF06853.12 EEA22891.1 - 0.039 14.0 0.2 0.068 13.2 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1249) Soc PF16855.5 EEA22891.1 - 0.092 13.3 0.0 0.95 10.0 0.0 2.2 2 0 0 2 2 2 0 Small outer capsid protein Levi_coat PF01819.17 EEA22891.1 - 0.12 12.4 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 Levivirus coat protein Pam16 PF03656.13 EEA22894.1 - 6.6e-33 113.4 0.4 1.1e-32 112.8 0.4 1.3 1 0 0 1 1 1 1 Pam16 Aldo_ket_red PF00248.21 EEA22895.1 - 5.1e-57 193.3 0.0 6.3e-57 193.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_3 PF01596.17 EEA22896.1 - 1.7e-12 47.0 0.0 2.3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EEA22896.1 - 5.3e-10 40.3 0.0 1.1e-09 39.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EEA22896.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Cephalosporin hydroxylase MFS_1 PF07690.16 EEA22897.1 - 4.3e-23 81.8 32.1 4.3e-23 81.8 32.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Cad PF03596.13 EEA22898.1 - 3.5e-24 85.8 8.5 4.7e-24 85.3 8.5 1.1 1 0 0 1 1 1 1 Cadmium resistance transporter Insulin_TMD PF17870.1 EEA22898.1 - 0.73 9.9 7.0 15 5.8 0.0 3.3 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment Fungal_trans PF04082.18 EEA22899.1 - 1.5e-24 86.5 0.3 3.7e-24 85.2 0.3 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain NACHT PF05729.12 EEA22900.1 - 6.4e-09 35.9 0.1 1.5e-08 34.7 0.1 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EEA22900.1 - 2.7e-08 34.2 0.0 1.3e-07 32.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA22900.1 - 1.1e-06 29.2 0.0 4.4e-06 27.2 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EEA22900.1 - 6.7e-05 23.3 0.0 0.0055 17.1 0.0 3.7 3 2 1 4 4 4 1 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 EEA22900.1 - 0.00024 20.4 0.0 0.0023 17.2 0.0 2.2 2 0 0 2 2 2 1 KAP family P-loop domain ATPase_2 PF01637.18 EEA22900.1 - 0.0066 16.4 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TsaE PF02367.17 EEA22900.1 - 0.021 14.8 0.0 0.05 13.6 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EEA22900.1 - 0.037 14.4 0.0 0.12 12.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Cir_Bir_Yir PF06022.11 EEA22900.1 - 0.089 12.3 0.2 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir ABC_tran PF00005.27 EEA22900.1 - 0.1 13.1 0.0 0.76 10.3 0.0 2.4 3 0 0 3 3 3 0 ABC transporter Rad17 PF03215.15 EEA22900.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain NAD_binding_10 PF13460.6 EEA22902.1 - 4.7e-13 49.4 0.0 6.2e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA22902.1 - 1e-08 34.9 0.0 1.3e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA22902.1 - 0.00012 21.6 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EEA22902.1 - 0.00035 20.2 0.2 0.00049 19.7 0.2 1.3 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 EEA22902.1 - 0.00099 18.3 0.1 0.0013 17.9 0.1 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain TrkA_N PF02254.18 EEA22902.1 - 0.0014 18.9 0.0 0.0019 18.4 0.0 1.2 1 0 0 1 1 1 1 TrkA-N domain Semialdhyde_dh PF01118.24 EEA22902.1 - 0.013 15.9 0.0 0.02 15.3 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EEA22902.1 - 0.052 13.7 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CbiJ PF02571.14 EEA22902.1 - 0.14 11.6 0.1 0.2 11.1 0.1 1.2 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK Hemerythrin PF01814.23 EEA22903.1 - 1.2e-10 42.1 0.4 1.8e-10 41.6 0.4 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain ALMT PF11744.8 EEA22904.1 - 2.1 7.1 5.6 3.9 6.2 5.6 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter FAA_hydrolase PF01557.18 EEA22905.1 - 4.1e-55 186.8 0.0 5.3e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Tnp_P_element_C PF12596.8 EEA22905.1 - 0.097 13.2 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 87kDa Transposase B12-binding PF02310.19 EEA22906.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 B12 binding domain Abhydrolase_1 PF00561.20 EEA22907.1 - 2.2e-18 66.9 0.0 1.9e-16 60.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA22907.1 - 3.6e-15 57.2 0.0 4.6e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA22907.1 - 7.7e-09 35.2 0.0 1.3e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EEA22907.1 - 2.2e-05 24.7 0.0 3.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 EEA22907.1 - 0.00023 21.1 0.0 0.00037 20.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 EEA22907.1 - 0.00033 20.1 0.0 0.12 11.7 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 EEA22907.1 - 0.00059 19.4 0.0 0.00095 18.7 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EEA22907.1 - 0.0007 19.4 0.6 0.15 11.8 0.6 2.2 1 1 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 EEA22907.1 - 0.001 18.8 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 EEA22907.1 - 0.0045 15.9 0.1 0.013 14.4 0.2 1.8 2 1 0 2 2 2 1 Chlorophyllase enzyme Palm_thioest PF02089.15 EEA22907.1 - 0.0045 16.9 0.0 0.0058 16.5 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 EEA22907.1 - 0.018 14.9 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF2048 PF09752.9 EEA22907.1 - 0.044 12.9 0.0 0.72 8.9 0.0 2.0 2 0 0 2 2 2 0 Abhydrolase domain containing 18 Chlorophyllase PF07224.11 EEA22907.1 - 0.091 11.8 0.0 0.2 10.7 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase Ndr PF03096.14 EEA22907.1 - 0.13 11.0 0.0 0.23 10.1 0.0 1.6 1 1 0 1 1 1 0 Ndr family Collagen_mid PF15984.5 EEA22908.1 - 0.00042 20.1 2.1 0.00042 20.1 0.3 1.8 2 0 0 2 2 2 1 Bacterial collagen, middle region HSBP1 PF06825.12 EEA22908.1 - 0.023 14.5 7.9 6.6 6.7 0.0 5.7 6 0 0 6 6 6 0 Heat shock factor binding protein 1 TIP49 PF06068.13 EEA22909.1 - 9.4e-152 505.2 0.5 9.4e-152 505.2 0.5 1.3 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 EEA22909.1 - 4.4e-22 78.0 0.3 1.4e-21 76.4 0.3 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EEA22909.1 - 7.3e-08 32.9 0.7 0.00015 22.2 0.0 2.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA22909.1 - 8.4e-08 32.1 0.5 7.9e-05 22.4 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA22909.1 - 1e-06 29.2 0.4 5e-06 27.0 0.1 2.2 1 1 0 2 2 2 1 AAA ATPase domain DnaB_C PF03796.15 EEA22909.1 - 7.9e-06 25.4 0.4 1.6e-05 24.4 0.4 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 EEA22909.1 - 0.0012 18.3 0.4 0.016 14.6 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EEA22909.1 - 0.01 15.6 0.0 5.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EEA22909.1 - 0.017 15.5 1.3 0.41 11.0 1.3 2.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA22909.1 - 0.017 15.4 0.0 3.1 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA22909.1 - 0.057 13.0 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EEA22909.1 - 0.063 13.3 0.1 2 8.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EEA22909.1 - 0.066 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EEA22909.1 - 0.079 12.5 0.2 0.64 9.5 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 EEA22909.1 - 0.084 12.7 0.2 0.2 11.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain TFIID-31kDa PF02291.15 EEA22909.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit GYF PF02213.16 EEA22910.1 - 7.3e-14 51.2 2.4 2.1e-13 49.7 2.4 1.8 1 0 0 1 1 1 1 GYF domain UFD1 PF03152.14 EEA22911.1 - 9e-76 253.2 0.0 1.1e-75 252.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DUF829 PF05705.14 EEA22912.1 - 3.1e-40 138.6 0.0 1.8e-39 136.1 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) DUF4246 PF14033.6 EEA22913.1 - 1.1e-135 453.3 0.2 1.4e-135 453.0 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) RNA_pol_Rpb2_6 PF00562.28 EEA22914.1 - 8.7e-124 413.5 0.4 1.3e-123 413.0 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EEA22914.1 - 1.2e-55 188.2 0.7 1.8e-55 187.6 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EEA22914.1 - 7e-32 109.7 0.4 1.6e-31 108.5 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EEA22914.1 - 2.4e-26 92.6 3.3 5.9e-26 91.3 3.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EEA22914.1 - 5.7e-25 87.4 0.6 1.3e-24 86.2 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EEA22914.1 - 2.3e-19 69.3 0.0 5.6e-19 68.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EEA22914.1 - 9.4e-10 38.9 2.5 4.5e-09 36.7 2.5 2.3 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 zn-ribbon_14 PF16503.5 EEA22914.1 - 6 6.5 6.7 0.53 9.8 2.0 1.8 2 0 0 2 2 2 0 Zinc-ribbon PUF PF00806.19 EEA22915.1 - 7e-57 186.0 3.0 5.8e-08 32.0 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF4901 PF16244.5 EEA22915.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4901) ORC5_C PF14630.6 EEA22916.1 - 1.9e-83 280.3 0.0 2.5e-83 279.9 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EEA22916.1 - 2.2e-18 67.2 0.1 3.8e-18 66.4 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain GFA PF04828.14 EEA22917.1 - 6.4e-14 52.1 1.0 6.4e-14 52.1 1.0 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme E1-E2_ATPase PF00122.20 EEA22919.1 - 5.1e-43 146.7 4.6 5.1e-43 146.7 4.6 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EEA22919.1 - 2e-15 57.7 0.1 5.8e-15 56.2 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA22919.1 - 2.1e-11 43.3 0.0 4.3e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EEA22919.1 - 0.00034 20.7 0.0 0.00076 19.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA22919.1 - 0.013 15.3 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase AIM24 PF01987.17 EEA22919.1 - 0.025 14.4 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial biogenesis AIM24 DUF423 PF04241.15 EEA22919.1 - 0.77 10.0 6.3 0.22 11.8 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF423) EF-hand_4 PF12763.7 EEA22920.1 - 2.8e-40 136.5 0.0 8e-17 61.1 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EEA22920.1 - 1.1e-07 30.8 0.1 0.0022 17.4 0.0 4.3 5 0 0 5 5 5 2 EF hand UBA PF00627.31 EEA22920.1 - 2.5e-07 30.4 0.0 4.5e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_7 PF13499.6 EEA22920.1 - 5.4e-07 30.0 0.0 0.0042 17.5 0.0 3.9 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.6 EEA22920.1 - 8.8e-05 22.1 0.6 0.58 10.2 0.0 4.7 5 0 0 5 5 5 1 EF-hand domain EF-hand_8 PF13833.6 EEA22920.1 - 0.0011 18.7 0.1 0.62 10.0 0.1 4.1 4 1 1 5 5 5 1 EF-hand domain pair DUF3450 PF11932.8 EEA22920.1 - 0.0047 16.3 10.5 0.0047 16.3 10.5 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3450) Spc7 PF08317.11 EEA22920.1 - 0.014 14.3 31.3 0.1 11.5 16.2 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 EEA22920.1 - 0.016 14.6 25.6 0.06 12.7 12.5 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 EEA22920.1 - 1.5 8.9 35.8 1.9 8.6 10.3 3.0 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 EEA22920.1 - 1.5 7.8 17.3 2.8 6.9 17.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 EEA22920.1 - 5.7 7.2 25.7 0.35 11.1 5.5 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Tubulin PF00091.25 EEA22921.1 - 7.6e-67 225.3 0.0 1.2e-66 224.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EEA22921.1 - 7.1e-50 168.4 0.1 1.3e-49 167.6 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EEA22921.1 - 0.0012 18.5 0.0 0.0029 17.3 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Pga1 PF10333.9 EEA22922.1 - 4.7e-06 26.6 0.0 9.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator FPN1 PF06963.12 EEA22922.1 - 0.013 14.1 0.2 0.02 13.5 0.2 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) PsbI PF02532.14 EEA22922.1 - 0.029 14.3 1.0 0.064 13.2 1.0 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) TM_helix PF05552.12 EEA22922.1 - 0.13 12.3 0.4 0.28 11.2 0.4 1.6 1 0 0 1 1 1 0 Conserved TM helix RNA_pol_Rpc82 PF05645.13 EEA22923.1 - 1.6e-28 100.2 0.1 1.2e-27 97.3 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EEA22923.1 - 9.7e-15 54.4 5.9 4.3e-10 39.5 0.4 3.4 3 0 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EEA22923.1 - 2e-09 37.2 0.2 0.00033 20.5 0.1 2.8 2 0 0 2 2 2 2 TFIIE alpha subunit TrmB PF01978.19 EEA22923.1 - 1e-05 25.3 0.1 0.34 10.8 0.0 3.3 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 EEA22923.1 - 0.018 15.0 1.3 1.6 8.7 0.2 3.4 3 0 0 3 3 3 0 MarR family ANAPC2 PF08672.11 EEA22923.1 - 0.042 14.4 1.1 17 6.0 0.3 4.0 4 0 0 4 4 4 0 Anaphase promoting complex (APC) subunit 2 SMC_ScpB PF04079.16 EEA22923.1 - 0.28 10.8 3.0 2.1 8.0 0.1 3.2 4 0 0 4 4 4 0 Segregation and condensation complex subunit ScpB HxlR PF01638.17 EEA22923.1 - 0.31 10.9 2.1 7.6 6.5 0.2 3.2 2 1 1 3 3 3 0 HxlR-like helix-turn-helix Peptidase_M16 PF00675.20 EEA22924.1 - 1.2e-15 57.8 0.1 2.1e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA22924.1 - 4.8e-12 46.2 0.0 9.7e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Mito_carr PF00153.27 EEA22925.1 - 1e-27 95.9 2.2 4.9e-12 45.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Citrate_synt PF00285.21 EEA22926.1 - 3.1e-102 342.4 0.0 3.9e-102 342.0 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 EEA22926.1 - 0.086 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Eclosion hormone CTD_bind PF04818.13 EEA22927.1 - 1.1e-09 38.9 0.0 2.1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 EEA22927.1 - 1.2e-05 25.0 0.0 2.3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 EEA22928.1 - 9.4e-10 39.2 0.0 1.8e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 EEA22928.1 - 1e-05 25.3 0.0 1.9e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ALO PF04030.14 EEA22929.1 - 0.058 13.2 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 D-arabinono-1,4-lactone oxidase Cys_Met_Meta_PP PF01053.20 EEA22930.1 - 3.4e-152 506.4 0.0 3.9e-152 506.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EEA22930.1 - 2.4e-10 40.3 1.4 2.4e-10 40.3 1.4 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EEA22930.1 - 5.8e-09 35.6 0.2 1.9e-08 33.9 0.1 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EEA22930.1 - 9.5e-07 28.1 0.4 1.7e-06 27.3 0.4 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA22930.1 - 1.5e-06 27.7 0.0 2.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 EEA22930.1 - 0.0024 16.5 0.1 0.0031 16.1 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.16 EEA22930.1 - 0.0026 16.7 0.0 0.0039 16.1 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Asparaginase_C PF17763.1 EEA22930.1 - 0.0092 16.2 0.1 0.061 13.6 0.0 2.1 1 1 1 2 2 2 1 Glutaminase/Asparaginase C-terminal domain SepSecS PF05889.13 EEA22930.1 - 0.061 12.0 0.0 0.088 11.5 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS ABC_sub_bind PF04392.12 EEA22930.1 - 0.071 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter substrate binding protein MARVEL PF01284.23 EEA22931.1 - 2.1e-19 70.0 17.5 2.6e-19 69.7 17.5 1.1 1 0 0 1 1 1 1 Membrane-associating domain AA_permease PF00324.21 EEA22932.1 - 3.5e-133 444.7 50.5 4.1e-133 444.5 50.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA22932.1 - 7.8e-32 110.6 56.5 9.8e-32 110.3 56.5 1.1 1 0 0 1 1 1 1 Amino acid permease 2-Hacid_dh_C PF02826.19 EEA22933.1 - 2.2e-42 144.4 0.0 2.4e-30 105.2 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EEA22933.1 - 0.029 14.9 0.0 0.072 13.7 0.0 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EEA22933.1 - 0.056 13.6 0.0 0.097 12.8 0.0 1.4 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 EEA22933.1 - 0.11 13.1 0.0 0.19 12.2 0.0 1.4 1 1 0 1 1 1 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 EEA22933.1 - 0.25 10.6 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain AMP-binding PF00501.28 EEA22934.1 - 1.3e-83 281.0 0.0 1.7e-83 280.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF1658 PF07871.11 EEA22934.1 - 0.1 12.5 0.2 2.1 8.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) DUF2012 PF09430.10 EEA22935.1 - 3.1e-31 108.0 0.0 4.2e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) Peptidase_M24 PF00557.24 EEA22936.1 - 5.6e-18 65.4 0.0 8.4e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Mu-like_gpT PF10124.9 EEA22936.1 - 0.097 12.0 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Mu-like prophage major head subunit gpT Ank_2 PF12796.7 EEA22937.1 - 4.7e-65 216.2 9.6 3.9e-12 46.6 0.2 9.6 4 2 4 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA22937.1 - 1.6e-54 181.6 6.4 2.1e-07 31.4 0.0 12.2 10 2 2 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA22937.1 - 2.3e-42 138.1 12.9 0.00065 20.0 0.0 16.3 16 0 0 16 16 16 10 Ankyrin repeat Ank PF00023.30 EEA22937.1 - 5.3e-30 102.5 14.2 0.00069 20.0 0.0 13.9 14 0 0 14 14 14 6 Ankyrin repeat Ank_5 PF13857.6 EEA22937.1 - 6.5e-29 99.6 18.1 0.042 14.2 0.1 12.7 8 4 5 13 13 13 8 Ankyrin repeats (many copies) Clr5 PF14420.6 EEA22937.1 - 1.2e-15 57.5 0.3 3e-15 56.2 0.3 1.8 1 0 0 1 1 1 1 Clr5 domain WW PF00397.26 EEA22938.1 - 1.8e-10 40.7 0.5 4.3e-10 39.5 0.5 1.7 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 EEA22938.1 - 4.7e-05 23.6 26.3 4.7e-05 23.6 26.3 2.8 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2076) WD40 PF00400.32 EEA22939.1 - 5e-12 46.1 15.3 0.0042 17.9 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat Mito_carr PF00153.27 EEA22940.1 - 2e-53 178.3 1.4 1.8e-17 63.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.16 EEA22940.1 - 0.035 14.0 0.1 0.11 12.4 0.1 1.9 1 0 0 1 1 1 0 UcrQ family HMD PF03201.16 EEA22940.1 - 0.037 14.3 0.0 3.2 8.0 0.0 3.2 3 1 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase TadE PF07811.12 EEA22940.1 - 0.11 12.8 1.3 3 8.2 0.1 2.8 2 0 0 2 2 2 0 TadE-like protein PrcB_C PF14343.6 EEA22940.1 - 0.12 12.5 0.0 3.8 7.7 0.0 2.3 2 0 0 2 2 2 0 PrcB C-terminal VIGSSK PF14773.6 EEA22940.1 - 0.3 11.2 5.9 12 6.1 0.0 3.4 3 0 0 3 3 3 0 Helicase-associated putative binding domain, C-terminal ERAP1_C PF11838.8 EEA22941.1 - 1.4e-89 300.8 1.0 2.2e-89 300.1 1.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EEA22941.1 - 2.2e-83 279.1 1.4 2.2e-83 279.1 1.4 1.8 2 0 0 2 2 2 1 Peptidase family M1 domain Ras PF00071.22 EEA22941.1 - 3.8e-64 215.2 0.5 7.4e-64 214.2 0.5 1.5 1 0 0 1 1 1 1 Ras family Peptidase_M1_N PF17900.1 EEA22941.1 - 1.9e-38 132.5 0.0 1.7e-37 129.4 0.0 2.2 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Roc PF08477.13 EEA22941.1 - 1.7e-34 118.6 0.1 3.3e-34 117.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA22941.1 - 4.9e-15 55.4 0.1 1.1e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA22941.1 - 0.001 19.1 0.0 0.0021 18.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA22941.1 - 0.0036 17.2 0.3 1.3 8.9 0.0 2.5 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EEA22941.1 - 0.0039 16.6 0.1 0.0071 15.7 0.1 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA22941.1 - 0.0051 16.4 0.1 0.011 15.3 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EEA22941.1 - 0.017 14.6 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA PF00004.29 EEA22941.1 - 0.04 14.3 0.1 5.1 7.5 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA22941.1 - 0.14 12.5 0.0 0.35 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Ssl1 PF04056.14 EEA22942.1 - 8.2e-75 250.9 0.0 1.1e-74 250.5 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EEA22942.1 - 7.4e-19 67.7 8.7 7.4e-19 67.7 8.7 2.4 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EEA22942.1 - 2e-18 67.0 0.0 4.3e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EEA22942.1 - 4.1e-06 27.2 0.0 5.8e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF5572 PF17733.1 EEA22943.1 - 9.4e-22 76.6 0.8 2.1e-21 75.5 0.8 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Methyltransf_2 PF00891.18 EEA22944.1 - 9.5e-28 96.9 0.0 1.6e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EEA22944.1 - 0.0099 16.6 0.0 0.029 15.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 EEA22944.1 - 0.034 13.6 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_12 PF08242.12 EEA22944.1 - 0.044 14.5 0.0 0.11 13.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 EEA22944.1 - 0.054 13.0 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain NmrA PF05368.13 EEA22945.1 - 5.1e-22 78.6 0.1 6.7e-22 78.2 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA22945.1 - 7.8e-16 58.5 0.0 1.3e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA22945.1 - 0.0028 17.1 0.0 0.03 13.8 0.0 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family MFS_1 PF07690.16 EEA22946.1 - 3.8e-39 134.6 64.4 4.1e-27 95.0 42.5 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily FMN_red PF03358.15 EEA22947.1 - 5e-09 36.1 0.0 7.7e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EEA22947.1 - 9.3e-07 28.8 0.0 1.2e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EEA22947.1 - 1.7e-05 25.1 0.3 0.00016 21.9 0.2 2.4 1 1 1 2 2 2 2 Flavodoxin Flavodoxin_5 PF12724.7 EEA22947.1 - 0.0079 16.4 0.0 0.05 13.8 0.0 1.9 1 1 1 2 2 2 1 Flavodoxin domain Scytalone_dh PF02982.14 EEA22948.1 - 1.1e-72 243.0 0.8 1.4e-72 242.7 0.8 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EEA22948.1 - 5.3e-05 23.3 0.8 6.6e-05 23.0 0.8 1.1 1 0 0 1 1 1 1 SnoaL-like domain FAD_binding_3 PF01494.19 EEA22949.1 - 2.8e-69 234.0 0.0 1.2e-35 123.4 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Phe_hydrox_dim PF07976.12 EEA22949.1 - 2.1e-28 99.4 0.0 3.5e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_2 PF00890.24 EEA22949.1 - 5e-06 25.8 0.1 8.3e-06 25.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EEA22949.1 - 6.3e-06 25.1 0.0 9.3e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EEA22949.1 - 6.4e-06 25.6 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA22949.1 - 0.00012 21.5 0.0 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EEA22949.1 - 0.0002 20.6 0.1 0.00029 20.0 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EEA22949.1 - 0.00026 21.1 0.0 0.00074 19.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA22949.1 - 0.0004 19.5 0.2 0.00075 18.6 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EEA22949.1 - 0.00063 19.4 0.0 0.00097 18.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA22949.1 - 0.00077 18.8 0.0 0.0012 18.1 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EEA22949.1 - 0.0015 17.8 0.0 0.0025 17.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EEA22949.1 - 0.0018 17.6 0.0 0.0033 16.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EEA22949.1 - 0.0019 17.2 0.0 0.0036 16.2 0.0 1.5 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox PF00070.27 EEA22949.1 - 0.018 15.6 0.0 0.038 14.6 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EEA22949.1 - 0.044 14.0 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 EEA22949.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 EEA22950.1 - 2e-54 184.7 1.1 3.4e-54 183.9 1.1 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA22950.1 - 4.9e-47 159.9 1.3 6.5e-47 159.5 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA22950.1 - 1.9e-14 54.0 1.0 3e-14 53.3 1.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA22950.1 - 0.024 14.1 0.1 0.033 13.6 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA22950.1 - 0.12 12.3 0.9 0.2 11.5 0.9 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Shikimate_DH PF01488.20 EEA22950.1 - 0.13 12.3 0.5 0.56 10.3 0.5 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.17 EEA22950.1 - 0.14 11.2 0.4 0.24 10.5 0.2 1.4 2 0 0 2 2 2 0 RmlD substrate binding domain Fungal_trans PF04082.18 EEA22951.1 - 0.0038 16.3 2.1 0.0083 15.2 2.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.26 EEA22952.1 - 1.7e-78 263.7 0.0 4e-78 262.5 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EEA22952.1 - 4.8e-77 258.9 3.0 5.9e-76 255.4 0.2 3.1 2 1 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EEA22952.1 - 1.6e-43 149.4 0.0 1.5e-42 146.3 0.0 2.2 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA22952.1 - 3.5e-34 117.3 0.1 6.8e-34 116.4 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EEA22952.1 - 1.7e-25 90.5 0.0 5.1e-25 88.9 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 EEA22952.1 - 3.6e-21 75.3 6.9 1.8e-10 41.0 0.5 2.9 3 0 0 3 3 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 EEA22952.1 - 1.1e-13 51.1 0.0 1.9e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EEA22952.1 - 2.1e-05 24.0 0.0 4.3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EEA22952.1 - 0.00015 22.2 0.0 0.00038 20.9 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_3 PF07859.13 EEA22952.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA22952.1 - 0.14 11.4 0.0 0.51 9.6 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 WD40 PF00400.32 EEA22953.1 - 4.2e-11 43.2 0.6 2.4 9.2 0.0 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA22953.1 - 0.00018 21.7 0.0 18 5.7 0.0 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 EEA22953.1 - 1.5 8.2 7.1 2.2 7.6 7.1 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EEA22953.1 - 5.5 5.1 7.6 7.9 4.5 7.6 1.1 1 0 0 1 1 1 0 Nop14-like family PUF PF00806.19 EEA22954.1 - 3.7e-36 120.8 1.0 6e-06 25.7 0.0 8.9 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat zf-C2H2_assoc PF16606.5 EEA22954.1 - 7 6.9 6.5 5.4 7.3 0.9 2.5 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers TPT PF03151.16 EEA22955.1 - 2.8e-60 204.1 16.1 3.4e-60 203.8 16.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA22955.1 - 3.4e-08 33.7 33.9 2.7e-05 24.4 12.6 2.9 2 1 0 2 2 2 2 EamA-like transporter family Choline_transpo PF04515.12 EEA22957.1 - 8.5e-28 97.5 24.7 8.5e-28 97.5 24.7 2.4 2 1 0 2 2 2 1 Plasma-membrane choline transporter Ras PF00071.22 EEA22958.1 - 9.5e-49 165.1 0.0 2.5e-46 157.2 0.0 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EEA22958.1 - 1.2e-29 102.9 0.0 5e-19 68.7 0.0 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA22958.1 - 1.2e-09 37.9 0.0 3.9e-09 36.2 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA22958.1 - 5.8e-09 35.8 0.0 1.4e-08 34.5 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EEA22958.1 - 3e-07 30.0 0.0 6.6e-07 28.9 0.0 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA22958.1 - 9.2e-05 22.5 0.1 0.0008 19.5 0.0 2.4 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA22958.1 - 0.0055 16.6 0.0 1 9.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EEA22958.1 - 0.059 13.7 0.4 0.44 10.8 0.2 2.5 2 1 0 2 2 2 0 AAA domain PMT PF02366.18 EEA22959.1 - 2e-87 292.9 15.8 2e-87 292.9 15.8 1.8 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EEA22959.1 - 2e-64 216.9 13.7 2e-64 216.9 13.7 2.6 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EEA22959.1 - 2.1e-35 122.3 0.5 3.2e-35 121.6 0.5 1.2 1 0 0 1 1 1 1 MIR domain Sugar_tr PF00083.24 EEA22960.1 - 2e-104 350.0 10.2 2.4e-104 349.8 10.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA22960.1 - 6.9e-30 104.2 29.3 2.4e-23 82.6 9.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA22960.1 - 2.7e-09 36.1 16.7 1.5e-07 30.4 5.4 2.8 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 EEA22960.1 - 0.012 14.5 5.8 0.82 8.5 0.2 2.3 1 1 0 2 2 2 0 MFS_1 like family INSIG PF07281.12 EEA22960.1 - 0.035 13.7 1.7 0.081 12.6 1.7 1.5 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) Mito_carr PF00153.27 EEA22961.1 - 1.4e-18 66.6 0.9 2e-11 43.6 0.1 3.0 2 1 0 2 2 2 2 Mitochondrial carrier protein SPT16 PF08644.11 EEA22962.1 - 1.7e-57 193.9 0.0 1.7e-57 193.9 0.0 2.2 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EEA22962.1 - 2e-55 187.0 0.0 2e-55 187.0 0.0 2.3 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EEA22962.1 - 1.7e-25 89.9 0.0 2.7e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EEA22962.1 - 4.3e-15 55.9 0.4 2.3e-14 53.6 0.0 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Peptidase_M43 PF05572.13 EEA22963.1 - 1.9e-11 44.1 0.0 4.1e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 EEA22963.1 - 0.083 13.0 5.1 0.16 12.1 4.9 1.8 1 1 0 1 1 1 0 Metallo-peptidase family M12 DUF2673 PF10880.8 EEA22963.1 - 0.19 11.9 1.6 7.6 6.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2673) CDC50 PF03381.15 EEA22964.1 - 5.6e-97 324.6 0.0 6.8e-97 324.3 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF3185 PF11381.8 EEA22964.1 - 0.54 10.3 7.7 0.077 13.0 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) SWIRM PF04433.17 EEA22965.1 - 4.6e-11 42.9 0.0 8.7e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain Ribonucleas_3_3 PF14622.6 EEA22966.1 - 1.1e-14 54.7 0.0 2.9e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EEA22966.1 - 6.9e-14 52.4 0.0 1.9e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EEA22967.1 - 1.1e-14 54.7 0.0 1.7e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EEA22967.1 - 5.1e-14 52.8 0.0 1.2e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease III domain MRP-S33 PF08293.11 EEA22968.1 - 4.9e-30 103.6 0.1 6e-30 103.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ank_2 PF12796.7 EEA22969.1 - 3.8e-19 69.1 0.0 9.7e-05 22.9 0.0 4.8 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA22969.1 - 9.3e-19 65.6 8.1 0.01 16.3 0.0 9.8 11 0 0 11 11 11 4 Ankyrin repeat Ank_4 PF13637.6 EEA22969.1 - 5e-18 65.2 1.0 0.079 13.6 0.0 7.4 6 3 2 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EEA22969.1 - 3.8e-17 61.9 2.1 0.008 16.6 0.1 9.1 9 2 1 10 10 10 3 Ankyrin repeat Ank_5 PF13857.6 EEA22969.1 - 2.3e-12 46.9 4.8 0.0055 17.0 0.0 5.7 6 0 0 6 6 6 4 Ankyrin repeats (many copies) F-box-like PF12937.7 EEA22969.1 - 0.00015 21.6 1.3 0.00015 21.6 1.3 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EEA22969.1 - 0.015 15.2 0.4 0.036 14.0 0.4 1.6 1 0 0 1 1 1 0 F-box domain Metallophos PF00149.28 EEA22970.1 - 1.2e-12 48.8 0.0 1.8e-12 48.2 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA22970.1 - 3.1e-08 34.0 0.0 4.9e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EEA22970.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily MFS_1 PF07690.16 EEA22973.1 - 8.2e-15 54.6 7.7 9.7e-15 54.3 7.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA22973.1 - 4e-06 26.0 2.1 4.9e-06 25.7 2.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Hemerythrin PF01814.23 EEA22974.1 - 0.11 13.1 0.2 0.15 12.6 0.2 1.2 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain PP-binding PF00550.25 EEA22975.1 - 5.3e-07 29.9 1.3 7.6e-07 29.4 1.3 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site Asp PF00026.23 EEA22976.1 - 1.6e-40 139.5 0.0 1.8e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease DDE_1 PF03184.19 EEA22978.1 - 9.4e-09 35.2 0.1 1.7e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 EEA22979.1 - 1.2e-33 116.2 0.0 2.2e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22979.1 - 3.1e-11 43.2 1.1 9.8e-11 41.5 0.0 2.3 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA22979.1 - 2.9e-07 30.1 0.0 7.8e-07 28.7 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-CCHC_2 PF13696.6 EEA22979.1 - 0.094 12.6 2.0 0.17 11.7 2.0 1.5 1 0 0 1 1 1 0 Zinc knuckle ORF6N PF10543.9 EEA22979.1 - 0.42 10.8 2.0 1.5 9.1 0.0 2.6 3 0 0 3 3 3 0 ORF6N domain zf-CCHC PF00098.23 EEA22979.1 - 0.44 10.7 2.5 0.78 9.9 2.5 1.4 1 0 0 1 1 1 0 Zinc knuckle DDE_1 PF03184.19 EEA22980.1 - 1.3e-19 70.5 0.0 2.7e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA22980.1 - 5.7e-10 39.1 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA22980.1 - 1.8e-06 27.6 0.0 3.8e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Herpes_UL14 PF03580.14 EEA22980.1 - 0.0075 16.5 2.0 0.9 9.8 1.0 2.5 2 0 0 2 2 2 2 Herpesvirus UL14-like protein DDE_3 PF13358.6 EEA22980.1 - 0.06 13.1 0.0 0.35 10.6 0.0 2.2 1 1 1 2 2 2 0 DDE superfamily endonuclease HTH_28 PF13518.6 EEA22980.1 - 0.066 13.3 0.1 0.51 10.5 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain RVT_1 PF00078.27 EEA22981.1 - 2.6e-18 66.3 0.0 4.1e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 EEA22981.1 - 2.3e-05 25.0 0.0 8e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase DUF382 PF04037.13 EEA22985.1 - 4.4e-59 198.2 0.9 1e-58 197.0 0.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 EEA22985.1 - 1.9e-20 72.4 3.8 3.8e-20 71.5 3.8 1.5 1 0 0 1 1 1 1 PSP ER_lumen_recept PF00810.18 EEA22987.1 - 2.7e-56 190.5 9.1 4.8e-56 189.7 9.1 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EEA22987.1 - 0.00022 21.0 12.3 0.34 10.7 0.1 4.4 3 2 2 5 5 5 3 PQ loop repeat Integrase_H2C2 PF17921.1 EEA22988.1 - 9.4e-08 32.1 0.8 9.4e-08 32.1 0.8 2.0 3 0 0 3 3 3 1 Integrase zinc binding domain XRCC4 PF06632.12 EEA22990.1 - 1.3e-06 27.6 17.9 2.1e-06 26.8 17.9 1.5 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 TFIIF_alpha PF05793.12 EEA22990.1 - 0.12 11.0 23.4 0.19 10.3 23.4 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Baculo_PEP_C PF04513.12 EEA22990.1 - 0.67 10.0 13.5 1.3 9.0 4.0 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 EEA22990.1 - 1.8 9.0 6.6 1.3 9.5 0.3 3.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Molybdopterin PF00384.22 EEA22991.1 - 5e-72 243.2 0.0 9.8e-70 235.7 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 EEA22991.1 - 4.4e-18 65.7 0.1 1.1e-17 64.5 0.1 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EEA22991.1 - 1.8e-17 62.6 0.2 1.8e-17 62.6 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.6 EEA22991.1 - 6.1e-16 58.2 0.3 2.4e-15 56.3 0.3 2.1 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 EEA22991.1 - 6.2e-05 22.9 2.7 6.6e-05 22.8 0.2 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 EEA22991.1 - 0.095 12.4 0.0 1.9 8.2 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 EEA22991.1 - 0.11 12.4 1.1 3.4 7.6 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 EEA22991.1 - 0.21 11.7 2.2 4 7.6 2.2 2.6 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Fer4_17 PF13534.6 EEA22991.1 - 4.2 8.0 6.5 0.45 11.1 1.4 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 EEA22991.1 - 7.7 7.3 6.5 1.5 9.5 1.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Aldo_ket_red PF00248.21 EEA22992.1 - 9e-47 159.7 0.1 5e-45 154.0 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family PurL_C PF16904.5 EEA22992.1 - 0.16 12.3 0.1 0.78 10.1 0.0 2.0 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine synthase II C-terminus UPF0061 PF02696.14 EEA22993.1 - 6.8e-132 440.6 0.0 9.2e-132 440.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family zf-CCHC PF00098.23 EEA22994.1 - 2.3e-53 176.0 65.3 4.9e-09 35.9 1.8 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EEA22994.1 - 1e-11 44.4 43.1 0.018 14.8 1.3 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 EEA22994.1 - 1.8e-06 27.5 44.6 0.08 12.7 1.0 7.1 5 1 2 7 7 7 7 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 EEA22994.1 - 1.6e-05 24.8 53.7 0.052 13.5 1.4 7.0 3 2 4 7 7 7 6 Zinc knuckle zf-CCHC_6 PF15288.6 EEA22994.1 - 2.3 8.1 49.2 0.5 10.2 1.6 7.0 6 1 1 7 7 7 0 Zinc knuckle F-box-like PF12937.7 EEA22995.1 - 2.9e-09 36.7 0.2 6.5e-09 35.5 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA22995.1 - 4.6e-09 35.9 0.4 1.2e-08 34.6 0.4 1.8 1 0 0 1 1 1 1 F-box domain SAE2 PF08573.10 EEA22996.1 - 6.9e-33 114.1 0.2 6.9e-33 114.1 0.2 3.0 2 0 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Fmp27_WPPW PF10359.9 EEA22996.1 - 0.0023 16.9 2.3 0.0046 15.9 2.3 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Ribosomal_60s PF00428.19 EEA22996.1 - 0.003 18.1 9.7 0.011 16.3 9.7 2.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein ADIP PF11559.8 EEA22996.1 - 0.17 12.0 7.6 1.1 9.3 3.2 2.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Ribosomal_L29 PF00831.23 EEA22996.1 - 0.45 10.5 3.5 12 6.0 0.1 3.5 3 0 0 3 3 3 0 Ribosomal L29 protein CDC45 PF02724.14 EEA22996.1 - 1.1 7.5 6.4 1.6 6.9 6.4 1.2 1 0 0 1 1 1 0 CDC45-like protein WRNPLPNID PF15017.6 EEA22996.1 - 1.4 9.8 14.6 7 7.6 14.6 2.3 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box AATF-Che1 PF13339.6 EEA22996.1 - 1.6 9.4 9.3 1.9 9.2 3.1 3.2 3 0 0 3 3 3 0 Apoptosis antagonizing transcription factor DUF3450 PF11932.8 EEA22996.1 - 2.5 7.4 10.9 4.5 6.5 6.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DNA_pol_phi PF04931.13 EEA22996.1 - 8.7 4.3 15.2 20 3.1 15.2 1.6 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EEA22996.1 - 9.6 5.4 13.0 17 4.6 13.0 1.3 1 0 0 1 1 1 0 NOA36 protein Pex16 PF08610.10 EEA22997.1 - 1.2e-140 468.3 0.0 1.4e-140 468.1 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Pex16 PF08610.10 EEA22998.1 - 1.2e-140 468.3 0.0 1.4e-140 468.1 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Pex16 PF08610.10 EEA22999.1 - 1.5e-137 458.1 0.0 5.9e-125 416.7 0.0 2.0 1 1 1 2 2 2 2 Peroxisomal membrane protein (Pex16) RNase_HII PF01351.18 EEA23000.1 - 7.9e-48 162.9 0.0 8.8e-43 146.5 0.0 2.1 1 1 1 2 2 2 2 Ribonuclease HII CENP-C_C PF11699.8 EEA23001.1 - 3.6e-35 120.0 0.8 6.2e-35 119.3 0.8 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 EEA23001.1 - 7e-33 114.2 6.8 7e-33 114.2 6.8 3.3 3 0 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 EEA23001.1 - 6.4e-06 25.8 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Cupin domain GFO_IDH_MocA PF01408.22 EEA23002.1 - 5.2e-18 66.0 0.0 8.1e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EEA23002.1 - 0.00018 22.1 0.0 0.0003 21.4 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ADK PF00406.22 EEA23003.1 - 1.5e-59 200.4 0.0 1.9e-59 200.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EEA23003.1 - 8.4e-23 81.3 0.0 1.4e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EEA23003.1 - 9.9e-18 63.8 0.0 2.6e-17 62.5 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EEA23003.1 - 5.7e-07 30.1 0.0 8.6e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA23003.1 - 6.8e-06 26.3 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EEA23003.1 - 0.071 13.3 0.0 0.11 12.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EEA23003.1 - 0.086 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Thymidylate_kin PF02223.17 EEA23003.1 - 0.11 12.1 0.0 0.35 10.5 0.0 1.8 2 0 0 2 2 2 0 Thymidylate kinase TSC22 PF01166.18 EEA23003.1 - 0.14 12.5 0.1 0.37 11.2 0.1 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family MitMem_reg PF13012.6 EEA23004.1 - 4.2e-37 127.0 0.5 7.9e-37 126.1 0.5 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EEA23004.1 - 2e-30 105.2 0.0 4.6e-30 104.0 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SWIM PF04434.17 EEA23005.1 - 0.0025 17.5 1.7 0.19 11.4 0.2 2.4 2 0 0 2 2 2 2 SWIM zinc finger MFS_1 PF07690.16 EEA23007.1 - 1.2e-25 90.3 73.3 9.3e-15 54.4 35.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily DDE_1 PF03184.19 EEA23008.1 - 1.9e-19 70.0 0.0 9.7e-19 67.7 0.0 2.2 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA23008.1 - 3e-15 56.0 0.2 9e-14 51.3 0.0 2.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Med9 PF07544.13 EEA23008.1 - 0.025 14.6 1.3 0.22 11.6 0.6 2.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF1359 PF07097.11 EEA23008.1 - 0.069 13.4 1.2 0.15 12.3 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1359) HTH_24 PF13412.6 EEA23008.1 - 0.07 12.7 0.0 0.23 11.1 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 EEA23008.1 - 0.071 12.9 0.2 0.46 10.3 0.0 2.3 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain CAP_GLY PF01302.25 EEA23010.1 - 8.3e-25 86.6 0.0 1.3e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EEA23010.1 - 3.5e-14 53.0 0.0 6.2e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 EEA23010.1 - 1.2e-05 25.0 0.0 3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family CAP_GLY PF01302.25 EEA23011.1 - 8.3e-25 86.6 0.0 1.3e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EEA23011.1 - 3.5e-14 53.0 0.0 6.2e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 EEA23011.1 - 1.2e-05 25.0 0.0 3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Methyltransf_11 PF08241.12 EEA23012.1 - 5.2e-13 49.5 0.0 9.8e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA23012.1 - 4.1e-11 43.4 0.0 8.3e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA23012.1 - 5.8e-08 32.7 0.0 5.2e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA23012.1 - 2.3e-06 28.3 0.0 5.2e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA23012.1 - 8e-06 25.7 0.0 1.6e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DnaB_bind PF10410.9 EEA23012.1 - 0.0095 16.1 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 DnaB-helicase binding domain of primase MetW PF07021.12 EEA23012.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Myb_DNA-binding PF00249.31 EEA23013.1 - 1.6e-12 47.4 2.8 7.8e-10 38.8 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA23013.1 - 0.00014 22.0 4.0 0.014 15.7 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Roughex PF06020.11 EEA23013.1 - 0.24 10.5 2.7 0.45 9.6 2.7 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 EEA23013.1 - 0.27 10.8 8.8 0.58 9.7 8.8 1.5 1 0 0 1 1 1 0 Spt20 family SRR1 PF07985.12 EEA23014.1 - 8.7e-11 41.7 0.1 1.7e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 SRR1 CFIA_Pcf11 PF11526.8 EEA23015.1 - 4.3e-09 36.7 2.6 2.9e-08 34.1 2.6 2.5 1 1 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 EEA23015.1 - 5.3e-06 27.2 0.0 1.6e-05 25.6 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. VHS PF00790.19 EEA23015.1 - 0.019 14.8 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 VHS domain zf_UBZ PF18439.1 EEA23015.1 - 1.6 8.4 6.3 2.7 7.7 1.6 2.8 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 EEA23015.1 - 6.3 6.8 5.3 21 5.2 0.1 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Inhibitor_I9 PF05922.16 EEA23016.1 - 0.11 13.2 0.1 0.14 12.9 0.1 1.5 1 1 0 1 1 1 0 Peptidase inhibitor I9 HOOK PF05622.12 EEA23017.1 - 3.2e-22 78.5 73.6 6.1e-20 71.0 73.6 2.4 1 1 0 1 1 1 1 HOOK protein HALZ PF02183.18 EEA23017.1 - 0.031 14.5 1.6 0.031 14.5 1.6 7.3 6 2 2 8 8 8 0 Homeobox associated leucine zipper TPR_MLP1_2 PF07926.12 EEA23017.1 - 0.29 11.2 93.0 0.057 13.5 2.5 7.6 4 2 1 6 6 6 0 TPR/MLP1/MLP2-like protein KASH_CCD PF14662.6 EEA23017.1 - 2.9 7.7 88.4 0.017 15.0 21.7 5.9 2 2 3 5 5 5 0 Coiled-coil region of CCDC155 or KASH Pox_A_type_inc PF04508.12 EEA23017.1 - 4.7 7.2 18.5 2.2 8.3 1.1 5.3 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat Coprogen_oxidas PF01218.18 EEA23018.1 - 8.3e-134 444.9 0.0 3.9e-133 442.7 0.0 1.8 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase Apc15p PF05841.11 EEA23019.1 - 3.6e-16 60.1 2.0 7.3e-16 59.1 0.3 2.1 2 0 0 2 2 2 1 Apc15p protein Use1 PF09753.9 EEA23020.1 - 0.039 13.7 0.0 0.039 13.7 0.0 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 CHZ PF09649.10 EEA23022.1 - 8.7e-17 60.3 2.7 8.7e-17 60.3 2.7 3.1 3 0 0 3 3 3 1 Histone chaperone domain CHZ DNA_pol_phi PF04931.13 EEA23022.1 - 7 4.6 32.5 7.7 4.5 32.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi HSP70 PF00012.20 EEA23023.1 - 2.4e-258 858.3 6.5 2.7e-258 858.1 6.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA23023.1 - 3.5e-19 68.8 0.0 4.6e-18 65.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EEA23023.1 - 0.0017 18.1 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EEA23023.1 - 0.0031 17.9 3.2 7.5 7.0 0.0 3.6 3 1 0 3 3 3 2 Cell division protein FtsA StbA PF06406.11 EEA23023.1 - 0.029 13.6 0.0 0.063 12.5 0.0 1.5 2 0 0 2 2 2 0 StbA protein Hydantoinase_A PF01968.18 EEA23023.1 - 0.033 13.4 0.1 0.083 12.1 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase MetOD2 PF18548.1 EEA23023.1 - 7.2 6.8 8.0 1.5 9.0 0.0 2.9 3 0 0 3 3 3 0 Metanogen output domain 2 NCE101 PF11654.8 EEA23024.1 - 5.7e-08 32.3 0.0 8.4e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Non-classical export protein 1 Mito_carr PF00153.27 EEA23025.1 - 4.3e-29 100.3 2.9 5.2e-14 51.9 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Atg8 PF02991.16 EEA23026.1 - 2.7e-51 172.1 0.2 3.2e-51 171.8 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EEA23026.1 - 3e-06 27.5 0.0 3.6e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EEA23027.1 - 1.3e-48 163.4 0.3 1.6e-48 163.2 0.3 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EEA23027.1 - 3e-06 27.5 0.0 3.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EEA23028.1 - 2.7e-51 172.1 0.2 3.2e-51 171.8 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EEA23028.1 - 3e-06 27.5 0.0 3.6e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EEA23029.1 - 2.7e-51 172.1 0.2 3.2e-51 171.8 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EEA23029.1 - 3e-06 27.5 0.0 3.6e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 RNA_pol_Rpb1_1 PF04997.12 EEA23030.1 - 1.2e-79 268.0 0.0 2.3e-79 267.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EEA23030.1 - 8.1e-77 258.2 0.2 1.6e-76 257.3 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EEA23030.1 - 5.8e-69 231.6 0.0 1.3e-68 230.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EEA23030.1 - 2.1e-35 122.0 0.0 7.4e-35 120.2 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EEA23030.1 - 9.2e-28 96.3 0.1 2.7e-27 94.8 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Rpr2 PF04032.16 EEA23030.1 - 0.82 10.0 2.4 2.7 8.3 1.1 2.5 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain dCMP_cyt_deam_1 PF00383.23 EEA23031.1 - 5.3e-06 26.2 0.1 6.4e-05 22.8 0.1 2.3 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA23031.1 - 0.0016 18.2 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 2 MafB19-like deaminase TYA PF01021.19 EEA23031.1 - 0.77 10.1 5.2 4 7.8 0.1 2.8 3 0 0 3 3 3 0 TYA transposon protein Cyclin PF08613.11 EEA23032.1 - 1.9e-31 109.6 0.8 1.9e-31 109.6 0.8 2.5 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EEA23032.1 - 0.00014 21.6 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Arm PF00514.23 EEA23033.1 - 4.3e-18 64.7 4.8 3.6e-06 26.8 0.0 9.6 10 0 0 10 10 10 3 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EEA23033.1 - 0.0051 16.9 5.1 1.8 9.0 0.0 6.0 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EEA23033.1 - 0.064 13.3 1.5 2.5 8.1 0.1 3.1 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Fructosamin_kin PF03881.14 EEA23034.1 - 9.9e-43 146.4 0.0 1.1e-42 146.2 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase Cyclin_N PF00134.23 EEA23035.1 - 2.1e-08 33.9 0.1 4.6e-07 29.6 0.0 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain CTP_transf_1 PF01148.20 EEA23036.1 - 4.9e-80 269.1 25.2 6e-80 268.8 25.2 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family DUF3636 PF12331.8 EEA23037.1 - 1.5e-41 141.7 0.4 2.9e-41 140.8 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) LCD1 PF09798.9 EEA23037.1 - 1.6e-05 23.6 5.6 0.012 14.2 0.2 2.7 2 1 1 3 3 3 2 DNA damage checkpoint protein HMMR_N PF15905.5 EEA23037.1 - 0.0039 16.7 5.0 0.0058 16.2 5.0 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Fez1 PF06818.15 EEA23037.1 - 0.049 14.1 2.6 0.1 13.0 2.6 1.5 1 0 0 1 1 1 0 Fez1 CC2-LZ PF16516.5 EEA23037.1 - 0.13 12.6 7.5 0.5 10.8 7.5 1.9 1 1 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator YfhD PF14151.6 EEA23037.1 - 0.2 11.8 1.0 3.3 7.9 0.2 2.6 2 0 0 2 2 2 0 YfhD-like protein TPR_MLP1_2 PF07926.12 EEA23037.1 - 0.23 11.5 7.4 0.092 12.8 3.7 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.19 EEA23037.1 - 0.25 9.2 4.3 0.36 8.7 4.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 EEA23037.1 - 0.3 11.7 3.6 0.63 10.7 2.6 2.1 1 1 1 2 2 2 0 Initiation control protein YabA S4 PF01479.25 EEA23038.1 - 3e-14 52.4 0.0 6.5e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 S4 domain SPG4 PF17325.2 EEA23038.1 - 0.034 15.3 1.0 0.034 15.3 1.0 2.5 2 0 0 2 2 2 0 Stationary phase protein 4 S4_2 PF13275.6 EEA23038.1 - 0.076 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 S4 domain Peptidase_S64 PF08192.11 EEA23038.1 - 3.7 5.9 10.1 5.1 5.5 10.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 TraF PF13728.6 EEA23038.1 - 5.1 6.9 10.1 0.35 10.7 0.3 2.3 2 0 0 2 2 2 0 F plasmid transfer operon protein DNA_pol_phi PF04931.13 EEA23039.1 - 0.99 7.4 7.9 1 7.4 0.1 2.3 2 0 0 2 2 2 0 DNA polymerase phi PPP4R2 PF09184.11 EEA23039.1 - 4.5 6.8 16.6 1.1 8.7 9.2 2.4 2 0 0 2 2 2 0 PPP4R2 E1_dh PF00676.20 EEA23040.1 - 4.4e-114 380.5 0.1 5.3e-114 380.2 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EEA23040.1 - 0.0002 20.7 0.0 0.00037 19.8 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase PH_10 PF15411.6 EEA23041.1 - 1.1e-26 93.5 0.1 2.9e-26 92.1 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 EEA23041.1 - 1.9e-12 47.7 0.0 3.9e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EEA23041.1 - 3.5e-09 36.8 0.1 2.4e-07 30.8 0.0 3.0 2 1 0 2 2 2 1 von Willebrand factor type A domain zf-RING_2 PF13639.6 EEA23041.1 - 0.00089 19.5 5.4 0.0019 18.5 5.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EEA23041.1 - 0.0033 17.4 6.0 0.0064 16.4 6.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EEA23041.1 - 0.0043 17.3 2.9 0.012 15.9 2.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EEA23041.1 - 0.011 15.3 3.0 0.011 15.3 3.0 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 EEA23041.1 - 0.013 15.4 6.2 0.028 14.3 6.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA23041.1 - 0.014 15.2 4.9 0.039 13.8 4.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 EEA23041.1 - 0.048 14.0 4.8 0.1 13.0 4.8 1.6 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_3 PF13920.6 EEA23041.1 - 0.074 12.9 2.2 0.18 11.7 2.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 EEA23041.1 - 0.27 11.4 0.7 0.52 10.5 0.7 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3H2C3 PF17122.5 EEA23041.1 - 0.59 10.2 5.5 1.5 9.0 5.5 1.7 1 1 0 1 1 1 0 Zinc-finger zf-RING_11 PF17123.5 EEA23041.1 - 1.4 8.8 3.4 3.3 7.5 3.4 1.7 1 0 0 1 1 1 0 RING-like zinc finger Rod_cone_degen PF15201.6 EEA23041.1 - 1.5 8.9 3.8 4 7.6 0.1 2.8 2 0 0 2 2 2 0 Progressive rod-cone degeneration Cpn60_TCP1 PF00118.24 EEA23042.1 - 4e-148 494.1 7.1 4.6e-148 493.9 7.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 EEA23042.1 - 0.009 15.6 0.1 0.025 14.1 0.0 1.7 2 0 0 2 2 2 1 EAL domain PrpR_N PF06506.11 EEA23042.1 - 0.027 14.1 0.3 0.087 12.4 0.1 2.0 2 0 0 2 2 2 0 Propionate catabolism activator TFB6 PF17110.5 EEA23042.1 - 0.036 13.8 1.2 0.11 12.3 1.2 1.8 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH WRNPLPNID PF15017.6 EEA23042.1 - 0.063 14.2 9.8 0.18 12.7 9.8 1.8 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box RXT2_N PF08595.11 EEA23042.1 - 0.098 12.7 4.0 0.23 11.4 4.0 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal RPN2_C PF18004.1 EEA23042.1 - 0.16 11.9 2.4 0.37 10.7 2.4 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RNA_pol_3_Rpc31 PF11705.8 EEA23042.1 - 0.26 11.5 8.9 0.49 10.6 8.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Sigma70_ner PF04546.13 EEA23042.1 - 0.36 10.7 6.6 0.096 12.6 3.1 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region SDA1 PF05285.12 EEA23042.1 - 0.84 9.0 8.7 1.5 8.2 8.7 1.3 1 0 0 1 1 1 0 SDA1 Pns11_12 PF17464.2 EEA23042.1 - 1.2 8.8 3.5 2.1 8.0 3.5 1.3 1 0 0 1 1 1 0 Non-structural protein 11 and 12 CobT PF06213.12 EEA23042.1 - 2 7.7 9.5 4 6.8 9.5 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 EEA23042.1 - 3 7.5 6.0 6.2 6.5 6.0 1.5 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 EEA23042.1 - 3.1 5.8 13.0 5.4 5.0 13.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EEA23042.1 - 3.3 7.0 8.9 5.1 6.3 8.9 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EEA23042.1 - 3.7 8.0 12.8 8.7 6.8 12.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nop14 PF04147.12 EEA23042.1 - 5.2 5.2 10.8 1 7.5 7.0 1.6 2 0 0 2 2 2 0 Nop14-like family Ribosomal_L12 PF00542.19 EEA23043.1 - 9e-20 70.8 6.3 2.8e-18 66.0 4.6 2.3 2 0 0 2 2 2 2 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EEA23043.1 - 1e-11 44.3 9.0 1e-11 44.3 9.0 3.6 4 1 0 4 4 4 1 Ribosomal protein L7/L12 dimerisation domain SpoVIF PF14069.6 EEA23043.1 - 0.12 12.1 1.0 0.35 10.7 0.2 2.0 2 1 0 2 2 2 0 Stage VI sporulation protein F Glyoxalase PF00903.25 EEA23044.1 - 6.4e-12 45.8 0.0 1.3e-11 44.8 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EEA23044.1 - 2.6e-05 24.5 0.0 3.4e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EEA23044.1 - 0.0016 18.4 0.0 0.15 12.0 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EEA23044.1 - 0.11 13.2 0.0 1.2 10.0 0.0 2.1 1 1 0 1 1 1 0 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EEA23044.1 - 0.14 12.3 0.0 1.1 9.3 0.0 1.9 1 1 0 1 1 1 0 Glyoxalase-like domain PrpR_N PF06506.11 EEA23044.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Propionate catabolism activator Sel1 PF08238.12 EEA23045.1 - 2e-05 25.1 0.7 0.34 11.7 0.0 2.7 2 0 0 2 2 2 2 Sel1 repeat TPR_12 PF13424.6 EEA23045.1 - 0.0031 17.7 3.0 4.4 7.7 0.0 4.7 4 1 1 5 5 5 1 Tetratricopeptide repeat HMG_CoA_synt_C PF08540.10 EEA23045.1 - 0.038 13.6 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal ANAPC3 PF12895.7 EEA23045.1 - 0.073 13.3 2.0 3.6 7.9 0.4 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EEA23045.1 - 0.21 12.1 1.7 7.7 7.1 0.3 3.6 4 1 1 5 5 5 0 Tetratricopeptide repeat Velvet PF11754.8 EEA23046.1 - 1.9e-57 195.1 0.8 1.9e-57 195.1 0.8 2.5 2 1 0 2 2 2 1 Velvet factor Cohesin_HEAT PF12765.7 EEA23047.1 - 0.66 10.3 3.4 36 4.8 0.0 3.6 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion SYF2 PF08231.12 EEA23048.1 - 3.2e-58 196.6 16.7 3.2e-58 196.6 16.7 2.0 2 0 0 2 2 2 1 SYF2 splicing factor DUF4932 PF16286.5 EEA23048.1 - 2.8 7.2 6.5 5 6.3 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4932) SYF2 PF08231.12 EEA23049.1 - 1.3e-51 175.1 14.3 1.3e-51 175.1 14.3 2.0 2 0 0 2 2 2 1 SYF2 splicing factor DUF4932 PF16286.5 EEA23049.1 - 2.1 7.6 6.4 4.1 6.6 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4932) RIBIOP_C PF04950.12 EEA23049.1 - 5.5 6.3 8.1 0.97 8.8 1.8 2.2 2 0 0 2 2 2 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal NAD_binding_10 PF13460.6 EEA23050.1 - 2e-06 27.8 0.0 1.9e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA23050.1 - 1.3e-05 24.8 0.0 2.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA23050.1 - 0.0021 17.1 0.0 0.0069 15.4 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EEA23050.1 - 0.0053 16.0 0.1 0.061 12.5 0.0 2.4 2 1 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 EEA23050.1 - 0.0063 15.6 0.0 0.042 12.9 0.0 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain adh_short PF00106.25 EEA23050.1 - 0.013 15.0 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase KR PF08659.10 EEA23050.1 - 0.029 14.3 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 KR domain YEATS PF03366.16 EEA23051.1 - 7.7e-36 121.9 1.3 1.1e-35 121.4 1.3 1.3 1 0 0 1 1 1 1 YEATS family M16C_assoc PF08367.11 EEA23051.1 - 0.034 13.3 0.2 0.059 12.5 0.2 1.3 1 0 0 1 1 1 0 Peptidase M16C associated BC10 PF06726.12 EEA23052.1 - 2.3e-16 59.8 8.8 3.9e-16 59.0 8.8 1.4 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Chs7 PF12271.8 EEA23053.1 - 2e-108 362.2 6.5 2.4e-108 361.9 6.5 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DLH PF01738.18 EEA23054.1 - 7e-29 100.9 0.0 8.5e-29 100.7 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 EEA23054.1 - 0.011 15.4 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 EEA23054.1 - 0.011 15.7 0.0 0.22 11.4 0.0 2.0 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 EEA23054.1 - 0.021 14.4 0.0 0.027 14.0 0.0 1.1 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase MFS_1 PF07690.16 EEA23055.1 - 2.6e-47 161.5 47.1 1e-45 156.3 47.1 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA23055.1 - 7.5e-14 51.1 24.2 9.5e-14 50.7 24.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA23055.1 - 3.1e-11 42.8 6.7 3.1e-11 42.8 6.7 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 EEA23055.1 - 0.00018 20.5 23.9 0.015 14.2 3.2 2.3 2 0 0 2 2 2 2 MFS_1 like family PQ-loop PF04193.14 EEA23055.1 - 0.0074 16.0 0.5 0.0074 16.0 0.5 3.4 3 0 0 3 3 3 1 PQ loop repeat DUF1129 PF06570.11 EEA23055.1 - 0.29 10.6 0.0 0.29 10.6 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) Transp_cyt_pur PF02133.15 EEA23056.1 - 4.4e-89 299.3 41.7 5.5e-89 298.9 41.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Fungal_trans PF04082.18 EEA23057.1 - 3.2e-24 85.4 7.4 5e-24 84.8 7.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23057.1 - 1.9e-07 31.1 8.8 3.6e-07 30.2 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain P5-ATPase PF12409.8 EEA23057.1 - 0.041 14.0 1.4 0.081 13.0 0.1 2.1 2 0 0 2 2 2 0 P5-type ATPase cation transporter DDE_1 PF03184.19 EEA23058.1 - 3.7e-12 46.2 0.0 9.1e-11 41.7 0.0 2.5 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA23058.1 - 1.1e-08 35.0 0.3 3e-08 33.6 0.3 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA23058.1 - 0.024 14.8 0.1 0.5 10.5 0.0 2.7 3 0 0 3 3 3 0 Transcription factor Pcc1 Amidase PF01425.21 EEA23058.1 - 0.052 12.5 1.6 0.078 11.9 1.6 1.2 1 0 0 1 1 1 0 Amidase Polysacc_deac_1 PF01522.21 EEA23059.1 - 1.2e-08 34.9 0.0 2e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF3146 PF11344.8 EEA23059.1 - 0.014 15.0 0.1 0.09 12.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3146) Amidase PF01425.21 EEA23060.1 - 9e-86 288.6 0.2 1.1e-85 288.3 0.2 1.0 1 0 0 1 1 1 1 Amidase Melibiase_2 PF16499.5 EEA23061.1 - 8.2e-51 172.8 0.4 1.7e-50 171.8 0.4 1.6 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EEA23061.1 - 4.2e-12 45.9 0.1 1.1e-11 44.6 0.1 1.8 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Glyco_hydro_28 PF00295.17 EEA23062.1 - 1.3e-25 90.1 5.3 2e-25 89.6 5.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 EEA23062.1 - 0.00017 21.5 8.6 0.0009 19.1 5.2 3.0 1 1 1 2 2 2 1 Pectate lyase superfamily protein ERG4_ERG24 PF01222.17 EEA23063.1 - 1.5e-137 458.9 19.7 1.7e-137 458.7 19.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family zf-C3HC4 PF00097.25 EEA23064.1 - 1.8e-07 30.9 6.1 3.2e-07 30.1 6.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA23064.1 - 3e-07 30.1 6.6 2.7e-06 27.1 3.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA23064.1 - 6.4e-06 26.1 1.9 6.4e-06 26.1 1.9 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EEA23064.1 - 1.4e-05 25.4 8.1 0.00034 20.9 8.5 2.3 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EEA23064.1 - 5.5e-05 22.9 4.7 0.00012 21.9 4.7 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA23064.1 - 5.9e-05 23.1 5.1 0.00042 20.4 5.6 2.1 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EEA23064.1 - 6.7e-05 22.8 4.6 0.00021 21.2 4.5 2.0 1 1 1 2 2 2 1 zinc-RING finger domain TerY_C PF15616.6 EEA23064.1 - 0.14 12.2 0.4 0.3 11.2 0.4 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain Rxt3 PF08642.10 EEA23064.1 - 0.15 12.8 3.0 18 6.1 0.0 3.5 4 0 0 4 4 3 0 Histone deacetylation protein Rxt3 Prok-RING_4 PF14447.6 EEA23064.1 - 0.37 10.7 9.2 7.9 6.4 9.4 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-MIZ PF02891.20 EEA23064.1 - 0.57 10.0 10.1 3.3 7.5 9.1 2.4 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_11 PF17123.5 EEA23064.1 - 2.4 8.0 8.1 27 4.6 6.0 2.7 2 1 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 EEA23064.1 - 3.8 7.9 5.8 14 6.1 5.8 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF1682 PF07946.14 EEA23064.1 - 8.3 5.5 6.7 15 4.7 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) UCH PF00443.29 EEA23065.1 - 8.2e-45 153.3 0.0 1.2e-44 152.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA23065.1 - 6.7e-11 42.3 0.0 5.1e-10 39.5 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Cauli_VI PF01693.16 EEA23066.1 - 2.7e-39 133.2 7.8 3.3e-19 68.9 1.7 2.3 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 EEA23066.1 - 1.9e-37 128.6 0.0 4.2e-37 127.5 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EEA23066.1 - 0.0012 18.6 0.0 0.0041 16.9 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase-like Na_H_Exchanger PF00999.21 EEA23067.1 - 4.9e-47 160.5 24.1 6.2e-47 160.2 24.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Vma12 PF11712.8 EEA23067.1 - 7.1 6.7 6.7 13 5.9 0.2 2.8 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase p450 PF00067.22 EEA23068.1 - 3.6e-05 22.7 0.1 0.013 14.3 0.0 2.8 2 1 0 2 2 2 2 Cytochrome P450 VESA1_N PF12785.7 EEA23068.1 - 0.013 14.6 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 PTPLA PF04387.14 EEA23069.1 - 4.9e-59 198.7 5.0 6.7e-59 198.3 5.0 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Adaptin_binding PF10199.9 EEA23070.1 - 2e-16 60.7 7.8 2.1e-16 60.6 4.7 2.2 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 LSM PF01423.22 EEA23071.1 - 1.7e-15 56.4 0.2 2.3e-15 56.0 0.2 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA23071.1 - 0.091 12.9 0.1 0.16 12.1 0.1 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain LSM PF01423.22 EEA23072.1 - 1.3e-12 47.3 0.4 1.8e-12 46.8 0.4 1.2 1 0 0 1 1 1 1 LSM domain PGP_phosphatase PF09419.10 EEA23073.1 - 1.4e-54 184.2 0.0 1.7e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EEA23073.1 - 1.3e-05 25.1 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EEA23073.1 - 0.00052 20.4 0.1 0.19 12.0 0.0 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Homeodomain PF00046.29 EEA23074.1 - 7.1e-20 70.6 5.1 1.6e-19 69.5 5.1 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EEA23074.1 - 0.00071 19.4 0.6 0.0017 18.2 0.6 1.6 1 0 0 1 1 1 1 Homeobox KN domain Polysacc_lyase PF14099.6 EEA23075.1 - 2e-51 174.8 9.9 2.5e-51 174.5 9.9 1.1 1 0 0 1 1 1 1 Polysaccharide lyase Lactamase_B PF00753.27 EEA23075.1 - 0.0009 19.3 0.8 0.0015 18.5 0.8 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA23075.1 - 0.067 12.7 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Glyco_hydro_15 PF00723.21 EEA23076.1 - 3e-100 336.1 0.2 3.8e-100 335.8 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EEA23076.1 - 1.5e-35 121.0 1.5 2.2e-35 120.4 0.4 1.9 2 0 0 2 2 2 1 Starch binding domain SAP130_C PF16014.5 EEA23076.1 - 4.1 6.4 5.9 6.4 5.8 5.9 1.3 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus zf-C2H2_4 PF13894.6 EEA23078.1 - 0.0021 18.8 1.6 0.087 13.7 0.3 2.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-BED PF02892.15 EEA23078.1 - 0.015 15.3 0.0 0.05 13.6 0.0 1.9 1 0 0 1 1 1 0 BED zinc finger zf-C2H2 PF00096.26 EEA23078.1 - 0.038 14.4 3.3 0.79 10.3 0.3 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Herpeto_peptide PF14409.6 EEA23079.1 - 0.071 13.3 0.3 0.15 12.3 0.3 1.5 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Herpetosiphon DUF5525 PF17663.1 EEA23079.1 - 0.077 11.1 0.2 0.081 11.0 0.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5525) DUF1582 PF07621.11 EEA23080.1 - 0.045 13.7 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1582) PhoLip_ATPase_C PF16212.5 EEA23081.1 - 5.9e-73 245.7 22.8 5.9e-73 245.7 22.8 2.4 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA23081.1 - 2e-24 85.1 2.0 7.1e-23 80.1 0.2 2.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EEA23081.1 - 1.9e-12 48.0 0.9 2e-07 31.5 0.5 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EEA23081.1 - 9.7e-12 44.8 0.1 9.7e-12 44.8 0.1 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EEA23081.1 - 1.7e-11 44.0 0.0 1.3e-10 41.2 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA23081.1 - 0.022 14.5 0.2 0.022 14.5 0.2 2.0 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA23081.1 - 0.11 12.5 0.3 0.65 10.1 0.1 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase SRP_TPR_like PF17004.5 EEA23083.1 - 1.5e-21 76.5 2.2 4.1e-21 75.2 2.2 1.8 1 0 0 1 1 1 1 Putative TPR-like repeat SRP72 PF08492.12 EEA23083.1 - 4.2e-17 62.3 9.3 4.2e-17 62.3 9.3 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 EEA23083.1 - 6.9e-06 26.5 13.3 0.08 13.5 0.0 5.9 6 1 1 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA23083.1 - 0.052 13.8 5.0 5.7 7.2 3.7 3.9 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 EEA23083.1 - 0.24 11.8 8.0 6.9 7.1 0.1 4.0 4 1 0 4 4 4 0 Bacterial transcriptional activator domain TPR_7 PF13176.6 EEA23083.1 - 0.86 9.8 5.4 8.5 6.7 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA23083.1 - 3.4 8.0 11.7 54 4.2 2.0 5.2 7 0 0 7 7 7 0 Tetratricopeptide repeat DLH PF01738.18 EEA23084.1 - 6.4e-11 42.2 0.0 7.8e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Dioxygenase_C PF00775.21 EEA23084.1 - 0.12 11.8 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Dioxygenase Asp PF00026.23 EEA23085.1 - 2.1e-53 181.8 4.9 2.6e-53 181.5 4.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA23085.1 - 3.1e-05 24.3 1.1 0.00011 22.5 1.1 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA23085.1 - 0.00017 22.2 1.1 1.6 9.4 0.1 3.6 3 1 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 EEA23085.1 - 0.00047 20.0 0.8 0.11 12.2 0.2 3.1 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EEA23085.1 - 0.0031 18.0 0.1 0.22 12.1 0.0 2.8 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease Fringe PF02434.16 EEA23086.1 - 4.9e-10 39.3 0.2 1.7e-09 37.5 0.2 1.8 1 1 0 1 1 1 1 Fringe-like DUF604 PF04646.12 EEA23086.1 - 2.5e-07 30.4 0.0 4.2e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Fungal_trans PF04082.18 EEA23088.1 - 5.6e-14 51.8 1.0 1.2e-13 50.7 1.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23088.1 - 1.2e-09 38.1 10.8 2e-09 37.4 10.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trypan_PARP PF05887.11 EEA23088.1 - 0.0064 16.5 1.6 0.012 15.6 1.6 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) DUF5336 PF17270.2 EEA23088.1 - 0.11 12.1 0.6 0.22 11.2 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5336) CCDC53 PF10152.9 EEA23088.1 - 0.71 10.3 4.3 1.5 9.2 4.3 1.6 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TFIIA PF03153.13 EEA23088.1 - 1.7 8.5 10.3 2.3 8.1 10.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_15 PF00723.21 EEA23089.1 - 1.7e-102 343.5 0.8 2.1e-102 343.2 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EEA23089.1 - 1.6e-28 98.4 0.2 4.4e-28 97.0 0.2 1.8 1 0 0 1 1 1 1 Starch binding domain Alpha-amylase PF00128.24 EEA23090.1 - 9.2e-65 219.4 0.1 1.2e-64 219.0 0.1 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EEA23090.1 - 1.2e-27 96.0 0.2 2.4e-27 95.0 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) GHL15 PF14885.6 EEA23090.1 - 0.12 12.3 1.8 5.2 6.9 0.0 2.5 2 1 1 3 3 3 0 Hypothetical glycosyl hydrolase family 15 Homeobox_KN PF05920.11 EEA23091.1 - 5.8e-21 74.1 0.3 5.8e-21 74.1 0.3 1.8 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EEA23091.1 - 1.1e-06 28.3 0.6 2.2e-06 27.4 0.1 1.7 2 0 0 2 2 2 1 Homeodomain PEP_mutase PF13714.6 EEA23092.1 - 1.4e-34 119.6 0.2 1.9e-34 119.2 0.2 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EEA23092.1 - 1.6e-21 76.5 0.1 1.9e-21 76.1 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family FAD_binding_1 PF00667.20 EEA23094.1 - 5.1e-45 153.7 0.0 7.5e-45 153.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EEA23094.1 - 2.1e-10 41.2 0.0 9.3e-10 39.1 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Glyco_hydro_47 PF01532.20 EEA23095.1 - 1e-187 624.6 0.0 1.2e-187 624.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4368 PF14287.6 EEA23095.1 - 0.065 13.5 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) Med20 PF08612.11 EEA23096.1 - 2e-67 226.9 0.0 2.5e-67 226.5 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex BES1_N PF05687.13 EEA23096.1 - 0.34 11.3 5.5 0.84 10.0 5.5 1.7 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal EF-hand_1 PF00036.32 EEA23097.1 - 1.3e-41 137.0 11.6 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA23097.1 - 3.6e-36 123.4 5.3 3.9e-19 68.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EEA23097.1 - 1.9e-34 117.3 11.5 2.4e-15 56.1 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EEA23097.1 - 3.8e-30 101.2 8.5 7.1e-09 34.9 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EEA23097.1 - 6.8e-26 88.6 9.8 4.7e-06 25.9 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EEA23097.1 - 1.4e-16 60.5 0.4 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA23097.1 - 6.8e-10 38.8 1.6 0.00078 19.4 0.3 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EEA23097.1 - 5.9e-09 36.2 0.2 0.0016 18.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EEA23097.1 - 1e-06 28.6 0.1 0.008 16.2 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EEA23097.1 - 6.4e-06 26.2 1.6 2.3e-05 24.4 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EEA23097.1 - 9.4e-05 23.2 0.2 0.0025 18.6 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EEA23097.1 - 0.00013 21.9 0.3 0.35 10.8 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 EEA23097.1 - 0.00059 19.8 1.6 0.52 10.2 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 EEA23097.1 - 0.00062 20.1 0.7 0.66 10.3 0.1 2.6 2 1 1 3 3 3 2 RNA polymerase Rpb4 Dockerin_1 PF00404.18 EEA23097.1 - 0.0053 16.9 7.0 0.38 11.0 0.8 2.9 1 1 2 3 3 3 2 Dockerin type I domain DUF5580 PF17743.1 EEA23097.1 - 0.0057 15.3 0.0 0.0058 15.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EEA23097.1 - 0.0084 16.0 0.7 0.32 10.9 0.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 EEA23097.1 - 0.012 16.0 0.5 6.2 7.2 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain Poly_export PF02563.16 EEA23097.1 - 0.023 14.9 0.0 0.18 12.0 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein RuvA_C PF07499.13 EEA23097.1 - 0.058 13.9 0.1 8.5 6.9 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain dCache_2 PF08269.11 EEA23097.1 - 0.061 12.5 0.1 1 8.5 0.1 2.1 1 1 1 2 2 2 0 Cache domain MotA_activ PF09114.10 EEA23097.1 - 0.061 13.5 0.3 0.91 9.7 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain DUF4497 PF14924.6 EEA23097.1 - 0.092 13.2 0.0 8.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) RloB PF13707.6 EEA23097.1 - 0.11 12.7 1.3 0.72 10.0 0.2 2.1 1 1 1 2 2 2 0 RloB-like protein DUF5132 PF17195.4 EEA23097.1 - 0.16 12.1 0.5 21 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) EF-hand_8 PF13833.6 EEA23098.1 - 5.4e-32 109.4 5.8 1.3e-15 57.0 0.6 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EEA23098.1 - 1.5e-31 105.6 8.1 4.8e-10 38.3 0.9 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EEA23098.1 - 4.1e-28 97.6 4.2 1.9e-19 69.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA23098.1 - 1.2e-20 71.5 3.7 4.9e-09 35.4 0.0 3.5 3 2 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EEA23098.1 - 2.9e-19 67.6 5.1 6.3e-06 25.4 0.0 3.2 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 EEA23098.1 - 1.7e-11 44.3 0.8 0.0001 22.6 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA23098.1 - 2.1e-07 30.9 2.1 0.00037 20.4 0.3 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 EEA23098.1 - 4.6e-06 26.6 0.6 1.1e-05 25.4 0.2 1.8 2 0 0 2 2 2 1 Ca2+ insensitive EF hand SPARC_Ca_bdg PF10591.9 EEA23098.1 - 1.2e-05 25.5 0.3 0.00073 19.8 0.1 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EEA23098.1 - 1.3e-05 25.1 0.1 0.19 11.8 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 EEA23098.1 - 0.0001 23.1 0.1 0.001 19.9 0.1 1.9 1 1 1 2 2 2 1 EF-hand domain DUF5580 PF17743.1 EEA23098.1 - 0.0054 15.3 0.0 0.0058 15.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) TerB PF05099.13 EEA23098.1 - 0.011 15.6 0.8 0.45 10.5 0.1 2.1 1 1 1 2 2 2 0 Tellurite resistance protein TerB SurA_N_2 PF13623.6 EEA23098.1 - 0.013 15.4 0.7 0.16 11.9 0.2 2.1 1 1 1 2 2 2 0 SurA N-terminal domain RuvA_C PF07499.13 EEA23098.1 - 0.025 15.0 0.1 5.4 7.6 0.0 2.9 3 0 0 3 3 3 0 RuvA, C-terminal domain Poly_export PF02563.16 EEA23098.1 - 0.039 14.2 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein RNA_pol_Rpb4 PF03874.16 EEA23098.1 - 0.042 14.2 1.3 0.31 11.4 0.3 2.5 1 1 1 2 2 2 0 RNA polymerase Rpb4 Dockerin_1 PF00404.18 EEA23098.1 - 0.061 13.5 5.2 0.2 11.9 0.8 2.7 1 1 2 3 3 3 0 Dockerin type I domain dCache_2 PF08269.11 EEA23098.1 - 0.069 12.3 0.1 0.51 9.5 0.1 2.0 1 1 1 2 2 2 0 Cache domain Herpes_UL36 PF03586.13 EEA23098.1 - 0.073 12.4 0.1 3.6 6.8 0.0 2.0 1 1 1 2 2 2 0 Herpesvirus UL36 tegument protein DUF5132 PF17195.4 EEA23098.1 - 0.08 13.0 0.5 14 5.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) EF-hand_8 PF13833.6 EEA23099.1 - 5.4e-32 109.4 5.8 1.3e-15 57.0 0.6 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EEA23099.1 - 1.5e-31 105.6 8.1 4.8e-10 38.3 0.9 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EEA23099.1 - 4.1e-28 97.6 4.2 1.9e-19 69.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA23099.1 - 1.2e-20 71.5 3.7 4.9e-09 35.4 0.0 3.5 3 2 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EEA23099.1 - 2.9e-19 67.6 5.1 6.3e-06 25.4 0.0 3.2 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 EEA23099.1 - 1.7e-11 44.3 0.8 0.0001 22.6 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA23099.1 - 2.1e-07 30.9 2.1 0.00037 20.4 0.3 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 EEA23099.1 - 4.6e-06 26.6 0.6 1.1e-05 25.4 0.2 1.8 2 0 0 2 2 2 1 Ca2+ insensitive EF hand SPARC_Ca_bdg PF10591.9 EEA23099.1 - 1.2e-05 25.5 0.3 0.00073 19.8 0.1 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EEA23099.1 - 1.3e-05 25.1 0.1 0.19 11.8 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 EEA23099.1 - 0.0001 23.1 0.1 0.001 19.9 0.1 1.9 1 1 1 2 2 2 1 EF-hand domain DUF5580 PF17743.1 EEA23099.1 - 0.0054 15.3 0.0 0.0058 15.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) TerB PF05099.13 EEA23099.1 - 0.011 15.6 0.8 0.45 10.5 0.1 2.1 1 1 1 2 2 2 0 Tellurite resistance protein TerB SurA_N_2 PF13623.6 EEA23099.1 - 0.013 15.4 0.7 0.16 11.9 0.2 2.1 1 1 1 2 2 2 0 SurA N-terminal domain RuvA_C PF07499.13 EEA23099.1 - 0.025 15.0 0.1 5.4 7.6 0.0 2.9 3 0 0 3 3 3 0 RuvA, C-terminal domain Poly_export PF02563.16 EEA23099.1 - 0.039 14.2 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein RNA_pol_Rpb4 PF03874.16 EEA23099.1 - 0.042 14.2 1.3 0.31 11.4 0.3 2.5 1 1 1 2 2 2 0 RNA polymerase Rpb4 Dockerin_1 PF00404.18 EEA23099.1 - 0.061 13.5 5.2 0.2 11.9 0.8 2.7 1 1 2 3 3 3 0 Dockerin type I domain dCache_2 PF08269.11 EEA23099.1 - 0.069 12.3 0.1 0.51 9.5 0.1 2.0 1 1 1 2 2 2 0 Cache domain Herpes_UL36 PF03586.13 EEA23099.1 - 0.073 12.4 0.1 3.6 6.8 0.0 2.0 1 1 1 2 2 2 0 Herpesvirus UL36 tegument protein DUF5132 PF17195.4 EEA23099.1 - 0.08 13.0 0.5 14 5.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) SNARE PF05739.19 EEA23100.1 - 2.1e-16 59.7 1.7 5.1e-16 58.4 1.7 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EEA23100.1 - 0.01 15.5 13.8 0.026 14.2 13.8 1.7 1 1 0 1 1 1 0 Syntaxin KxDL PF10241.9 EEA23100.1 - 0.041 14.1 0.1 0.041 14.1 0.1 3.3 4 0 0 4 4 4 0 Uncharacterized conserved protein DUF2615 PF11027.8 EEA23100.1 - 0.07 13.3 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) DUF948 PF06103.11 EEA23100.1 - 2.1 8.6 6.9 32 4.9 0.1 3.9 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) HAUS-augmin3 PF14932.6 EEA23100.1 - 3.4 7.2 8.8 0.2 11.2 1.4 2.1 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 BBP1_C PF15272.6 EEA23100.1 - 4.2 7.1 11.1 2.3 8.0 2.3 2.5 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal DUF4407 PF14362.6 EEA23100.1 - 6 6.1 12.3 0.076 12.3 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) CTD_bind PF04818.13 EEA23101.1 - 4.4e-19 69.1 0.1 1.2e-18 67.6 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. DUF3277 PF11681.8 EEA23101.1 - 0.062 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) CTK3 PF12243.8 EEA23101.1 - 0.062 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 TetR_C_4 PF08359.11 EEA23101.1 - 0.64 10.2 2.4 1.4 9.0 0.3 2.5 3 0 0 3 3 3 0 YsiA-like protein, C-terminal region Clathrin_lg_ch PF01086.17 EEA23102.1 - 9e-75 251.7 2.1 1e-74 251.5 2.1 1.0 1 0 0 1 1 1 1 Clathrin light chain CDC37_N PF03234.14 EEA23103.1 - 1.5e-50 171.4 7.1 3.9e-50 170.1 2.7 2.9 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EEA23103.1 - 5.9e-41 139.1 0.2 3.7e-40 136.5 0.0 2.2 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EEA23103.1 - 1.6e-36 124.4 1.0 1.6e-36 124.4 1.0 2.7 3 0 0 3 3 3 1 Cdc37 C terminal domain Thiamine_BP PF01910.17 EEA23103.1 - 0.053 13.4 0.1 0.19 11.7 0.1 2.0 1 0 0 1 1 1 0 Thiamine-binding protein Cytochrom_B562 PF07361.11 EEA23103.1 - 0.054 14.2 0.7 3 8.5 0.2 3.1 2 1 0 2 2 2 0 Cytochrome b562 SusD-like_3 PF14322.6 EEA23103.1 - 0.072 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Starch-binding associating with outer membrane ABC_membrane PF00664.23 EEA23104.1 - 9.4e-50 169.8 8.3 1.2e-49 169.4 8.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EEA23104.1 - 1.2e-35 123.0 0.0 4.8e-35 121.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EEA23104.1 - 1.8e-05 24.3 0.0 0.0014 18.1 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA23104.1 - 0.004 17.4 0.1 0.038 14.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EEA23104.1 - 0.007 16.8 0.1 0.1 13.0 0.1 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA23104.1 - 0.0075 16.7 0.0 0.026 14.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EEA23104.1 - 0.01 15.5 0.0 0.029 14.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EEA23104.1 - 0.069 12.9 0.1 0.59 9.8 0.0 2.3 2 1 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 EEA23104.1 - 0.07 12.8 0.0 0.23 11.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EEA23104.1 - 0.13 12.2 0.1 0.81 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EEA23104.1 - 0.18 12.0 0.5 2.2 8.6 0.5 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EEA23104.1 - 0.48 10.9 4.1 0.73 10.3 0.1 2.7 3 0 0 3 3 3 0 AAA domain Nucleoside_tran PF01733.18 EEA23105.1 - 4.1e-43 147.9 7.8 4.1e-43 147.9 7.8 2.1 2 1 0 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 EEA23105.1 - 0.00052 19.0 33.9 0.00081 18.4 2.6 3.4 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF2975 PF11188.8 EEA23105.1 - 0.031 14.2 14.7 0.2 11.6 0.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2975) DUF1980 PF09323.10 EEA23105.1 - 1.1 9.1 0.0 1.1 9.1 0.0 2.5 3 1 0 3 3 3 0 Domain of unknown function (DUF1980) APH PF01636.23 EEA23106.1 - 0.0025 17.8 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA23107.1 - 3.6e-40 138.1 0.0 5e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain MSA-2c PF12238.8 EEA23107.1 - 0.59 10.1 6.5 1.3 9.0 6.5 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c COX7a PF02238.15 EEA23109.1 - 3.2e-23 81.9 2.3 4.2e-23 81.5 2.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Nitroreductase PF00881.24 EEA23111.1 - 1.6e-11 44.5 0.0 2.1e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family HmuY PF14064.6 EEA23111.1 - 0.089 13.0 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 HmuY protein Fungal_trans PF04082.18 EEA23112.1 - 2.9e-09 36.4 0.1 5.2e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aminotran_5 PF00266.19 EEA23113.1 - 1.5e-07 30.8 0.0 2.2e-06 26.9 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V IDO PF01231.18 EEA23114.1 - 5.7e-153 509.8 0.0 6.6e-153 509.6 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase IDO PF01231.18 EEA23115.1 - 8.5e-107 357.6 0.0 1e-106 357.4 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase HATPase_c_4 PF13749.6 EEA23115.1 - 0.21 11.7 0.6 3.2 8.0 0.1 2.2 2 0 0 2 2 2 0 Putative ATP-dependent DNA helicase recG C-terminal DUF4246 PF14033.6 EEA23116.1 - 3.8e-174 580.1 0.0 4.5e-174 579.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 EEA23116.1 - 0.039 14.4 0.0 0.088 13.2 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase DUF4246 PF14033.6 EEA23117.1 - 3.8e-174 580.1 0.0 4.5e-174 579.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 EEA23117.1 - 0.039 14.4 0.0 0.088 13.2 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Ins_P5_2-kin PF06090.12 EEA23118.1 - 3.6e-56 191.0 0.0 1.7e-55 188.8 0.0 1.8 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF3439 PF11921.8 EEA23118.1 - 0.46 10.5 8.6 0.91 9.5 8.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF1682 PF07946.14 EEA23119.1 - 1.3e-116 389.4 0.5 1.4e-116 389.2 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) CBF PF03914.17 EEA23119.1 - 0.088 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 CBF/Mak21 family Thiamine_BP PF01910.17 EEA23120.1 - 6.6e-29 99.7 0.0 7.6e-29 99.5 0.0 1.0 1 0 0 1 1 1 1 Thiamine-binding protein Ge1_WD40 PF16529.5 EEA23122.1 - 0.002 17.2 0.0 0.0037 16.3 0.0 1.4 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF445 PF04286.12 EEA23122.1 - 0.53 10.0 16.4 0.66 9.7 5.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF445) MbeD_MobD PF04899.12 EEA23122.1 - 3.3 7.9 7.7 6.4 7.0 3.3 3.0 2 0 0 2 2 2 0 MbeD/MobD like Adeno_VII PF03228.14 EEA23122.1 - 3.8 8.2 6.0 3.2 8.4 0.4 3.1 3 0 0 3 3 3 0 Adenoviral core protein VII Atg14 PF10186.9 EEA23122.1 - 8.9 5.3 12.7 0.49 9.4 1.7 2.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 GATase_2 PF00310.21 EEA23123.1 - 9.1e-181 601.1 0.0 1.2e-180 600.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EEA23123.1 - 1.9e-156 520.8 0.1 3.4e-156 520.0 0.0 1.5 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EEA23123.1 - 6.6e-115 383.4 0.0 3.2e-112 374.6 0.0 2.2 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 EEA23123.1 - 7.6e-85 283.3 3.4 1.2e-84 282.6 3.4 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EEA23123.1 - 1.2e-26 93.7 0.1 3.9e-26 92.0 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EEA23123.1 - 2.5e-21 75.6 0.1 5e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EEA23123.1 - 1.1e-08 35.2 0.0 3.6e-08 33.5 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA23123.1 - 4.4e-08 33.1 2.3 0.0024 17.5 0.7 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA23123.1 - 5.8e-08 33.2 0.2 6.6e-05 23.4 0.1 3.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA23123.1 - 4e-07 29.7 0.2 7.8e-07 28.7 0.2 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EEA23123.1 - 4.5e-07 29.4 1.2 0.019 14.2 0.0 3.8 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA23123.1 - 2e-05 24.2 0.8 4e-05 23.1 0.8 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA23123.1 - 4.8e-05 22.6 0.3 0.00019 20.7 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EEA23123.1 - 6.3e-05 21.8 0.3 6.3e-05 21.8 0.3 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 EEA23123.1 - 0.00023 20.5 0.0 0.00065 19.0 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 EEA23123.1 - 0.00031 21.1 0.1 1.3 9.5 0.1 2.8 2 0 0 2 2 2 2 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 EEA23123.1 - 0.0026 17.1 0.2 0.51 9.6 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FMO-like PF00743.19 EEA23123.1 - 0.0047 15.4 0.1 1.4 7.2 0.0 2.9 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like Thi4 PF01946.17 EEA23123.1 - 0.0048 16.2 0.3 0.028 13.6 0.1 2.2 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EEA23123.1 - 0.0052 15.9 0.5 0.35 9.9 0.2 2.5 2 0 0 2 2 2 1 Lycopene cyclase protein PG_isomerase_N PF18353.1 EEA23123.1 - 0.017 15.5 0.0 0.042 14.2 0.0 1.7 1 0 0 1 1 1 0 Phosphoglucose isomerase N-terminal domain 2-Hacid_dh_C PF02826.19 EEA23123.1 - 0.036 13.4 0.1 0.19 11.0 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EEA23123.1 - 0.092 11.8 3.2 0.052 12.6 0.2 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A AdoHcyase_NAD PF00670.21 EEA23123.1 - 0.24 11.5 0.7 24 5.0 0.1 2.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FMN_dh PF01070.18 EEA23123.1 - 0.39 9.7 2.2 1.2 8.1 1.8 2.0 2 0 0 2 2 2 0 FMN-dependent dehydrogenase DUF3128 PF11326.8 EEA23124.1 - 2.1e-26 92.1 3.5 2.1e-26 92.1 3.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3128) DUF4635 PF15466.6 EEA23124.1 - 0.065 12.8 0.4 0.1 12.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Ndc1_Nup PF09531.10 EEA23124.1 - 0.067 11.9 4.4 0.058 12.1 4.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup tRNA-synt_1c PF00749.21 EEA23125.1 - 1.7e-92 309.7 0.0 2.1e-92 309.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EEA23125.1 - 2.8e-28 99.0 0.0 1.3e-27 96.8 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain RNA12 PF10443.9 EEA23126.1 - 1e-158 528.8 0.0 1.4e-158 528.3 0.0 1.1 1 0 0 1 1 1 1 RNA12 protein RRM_1 PF00076.22 EEA23126.1 - 1.4e-05 24.8 0.0 3.1e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 EEA23126.1 - 0.00021 21.3 0.1 0.00062 19.7 0.1 1.9 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea ScsC_N PF18312.1 EEA23126.1 - 0.008 16.0 2.3 8.7 6.3 0.0 3.6 3 0 0 3 3 3 2 Copper resistance protein ScsC N-terminal domain DUF2487 PF10673.9 EEA23126.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) MFS_1 PF07690.16 EEA23127.1 - 1.4e-32 113.0 7.1 1.4e-32 113.0 7.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA23127.1 - 0.00046 19.6 0.1 0.00046 19.6 0.1 2.4 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB DUF2070 PF09843.9 EEA23127.1 - 0.083 11.2 0.1 0.12 10.6 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MscL PF01741.18 EEA23128.1 - 3.5e-18 66.1 0.0 4.5e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-BED PF02892.15 EEA23128.1 - 0.028 14.5 3.4 0.058 13.4 3.4 1.5 1 0 0 1 1 1 0 BED zinc finger C1_1 PF00130.22 EEA23128.1 - 0.056 13.3 1.4 0.11 12.4 1.4 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Vps39_2 PF10367.9 EEA23128.1 - 0.15 12.6 0.2 0.5 10.8 0.2 1.7 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 FMN_dh PF01070.18 EEA23129.1 - 3.1e-105 352.1 0.0 3.8e-105 351.8 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EEA23129.1 - 6.6e-20 71.0 0.0 2e-19 69.5 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EEA23129.1 - 1.1e-06 28.0 0.1 1.7e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EEA23129.1 - 4e-05 22.8 0.1 0.00017 20.7 0.0 2.0 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EEA23129.1 - 0.019 14.4 0.1 0.031 13.7 0.1 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase His_biosynth PF00977.21 EEA23129.1 - 0.072 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein Aminotran_1_2 PF00155.21 EEA23130.1 - 2.1e-65 221.3 0.0 2.6e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EEA23130.1 - 0.0025 17.2 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EEA23130.1 - 0.023 13.7 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Tmemb_18A PF09771.9 EEA23130.1 - 0.16 12.3 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 188 AMP-binding PF00501.28 EEA23131.1 - 2.1e-36 125.4 0.0 3.5e-36 124.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EEA23131.1 - 1.9e-10 40.5 0.5 3.9e-10 39.5 0.5 1.6 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Peptidase_M16_C PF05193.21 EEA23132.1 - 1.5e-51 175.0 0.0 3.2e-51 173.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA23132.1 - 1.3e-42 145.3 0.0 5.9e-41 139.9 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) TRPM_tetra PF16519.5 EEA23132.1 - 0.14 12.2 0.5 0.47 10.6 0.5 1.8 1 0 0 1 1 1 0 Tetramerisation domain of TRPM SMRP1 PF15181.6 EEA23132.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 Tom22 PF04281.13 EEA23133.1 - 1.4e-52 177.2 0.4 1.6e-52 177.0 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 PP1c_bdg PF10488.9 EEA23133.1 - 0.049 13.1 0.2 0.064 12.7 0.2 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region Tom22 PF04281.13 EEA23134.1 - 1.7e-41 141.2 0.1 2.1e-41 140.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF4211 PF13926.6 EEA23135.1 - 3.8e-39 134.0 2.0 4.9e-39 133.7 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) DUF4038 PF13204.6 EEA23137.1 - 0.097 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) GOLD_2 PF13897.6 EEA23137.1 - 0.15 12.5 1.5 0.26 11.8 1.5 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Sigma70_ner PF04546.13 EEA23137.1 - 0.35 10.7 5.4 0.61 9.9 5.4 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region CobT PF06213.12 EEA23137.1 - 0.4 10.0 11.1 0.57 9.5 11.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Roughex PF06020.11 EEA23137.1 - 0.99 8.4 6.8 1.4 7.9 6.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein SDA1 PF05285.12 EEA23137.1 - 1.9 7.8 9.3 2.5 7.4 9.3 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EEA23137.1 - 2.4 6.3 10.6 3.3 5.8 10.6 1.1 1 0 0 1 1 1 0 Nop14-like family BTB PF00651.31 EEA23138.1 - 6.1e-08 32.9 0.1 4e-06 27.0 0.1 2.2 1 1 0 2 2 2 2 BTB/POZ domain DUF1024 PF06260.12 EEA23138.1 - 0.043 14.1 0.0 0.075 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1024) DUF4449 PF14613.6 EEA23139.1 - 3.3e-60 202.9 2.2 3.3e-60 202.9 2.2 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF4449) Sporozoite_P67 PF05642.11 EEA23139.1 - 0.42 8.6 8.9 0.0067 14.6 1.3 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Prp18 PF02840.15 EEA23139.1 - 1.2 9.2 10.0 1.8 8.6 0.0 3.4 3 2 2 5 5 5 0 Prp18 domain ILVD_EDD PF00920.21 EEA23140.1 - 1e-161 539.1 0.1 1.2e-161 538.9 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family Mcl1_mid PF12341.8 EEA23141.1 - 2.6e-103 345.4 0.0 1.4e-102 343.1 0.0 2.1 2 1 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 EEA23141.1 - 1.8e-19 69.8 0.0 0.00048 20.4 0.0 7.9 3 1 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA23141.1 - 3.6e-16 59.2 5.0 2.1e-06 28.4 0.1 6.9 7 0 0 7 7 7 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EEA23141.1 - 6.5e-09 35.3 0.0 6.2e-07 28.8 0.0 2.6 1 1 1 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 EEA23141.1 - 3.1e-06 27.2 0.9 0.0036 17.2 0.1 3.6 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA23141.1 - 0.0037 16.3 0.4 5.8 5.8 0.1 3.6 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein MMS1_N PF10433.9 EEA23141.1 - 0.007 15.0 0.0 0.023 13.4 0.0 1.7 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term DNA_pol_alpha_N PF12254.8 EEA23141.1 - 0.018 15.1 4.0 0.11 12.6 1.7 2.5 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal Cytochrom_D1 PF02239.16 EEA23141.1 - 0.048 12.2 0.1 0.68 8.4 0.1 2.2 1 1 1 2 2 2 0 Cytochrome D1 heme domain IKI3 PF04762.12 EEA23141.1 - 0.072 11.1 0.1 0.44 8.5 0.1 2.1 1 1 0 1 1 1 0 IKI3 family PD40 PF07676.12 EEA23141.1 - 0.11 12.5 1.2 47 4.1 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat MMU163 PF17119.5 EEA23142.1 - 1.7e-107 358.2 0.0 2.6e-107 357.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis MFS_1 PF07690.16 EEA23143.1 - 1.2e-41 142.9 16.1 1.2e-41 142.9 16.1 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23143.1 - 3.3e-10 39.4 3.0 3.3e-10 39.4 3.0 1.8 1 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EEA23143.1 - 0.0014 17.1 1.3 0.0027 16.2 1.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EEA23143.1 - 0.012 14.5 3.5 0.036 12.9 1.0 3.0 2 1 0 2 2 2 0 MFS_1 like family LacY_symp PF01306.19 EEA23143.1 - 0.017 13.9 0.5 0.017 13.9 0.5 2.2 2 0 0 2 2 2 0 LacY proton/sugar symporter DUF1129 PF06570.11 EEA23143.1 - 0.022 14.3 5.0 5.4 6.4 0.0 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF1129) V_ATPase_I PF01496.19 EEA23144.1 - 3.1 5.6 5.3 4.3 5.1 5.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.12 EEA23144.1 - 6.1 7.4 8.9 11 6.6 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF3619 PF12279.8 EEA23144.1 - 7.4 6.9 13.4 0.21 11.9 5.8 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3619) NUDIX PF00293.28 EEA23146.1 - 1.3e-12 47.9 0.0 3.8e-12 46.4 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain VTC PF09359.10 EEA23147.1 - 4.3e-89 298.6 0.2 8.3e-89 297.6 0.2 1.5 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 EEA23147.1 - 2e-11 44.1 3.1 2e-11 44.1 3.1 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF202) SPX PF03105.19 EEA23147.1 - 3.5e-05 23.9 19.0 0.00013 22.1 0.1 4.1 3 1 2 5 5 5 3 SPX domain HCV_capsid PF01543.17 EEA23147.1 - 0.012 15.8 1.1 0.022 15.0 1.1 1.4 1 0 0 1 1 1 0 Hepatitis C virus capsid protein MerC PF03203.14 EEA23147.1 - 0.29 11.6 1.5 0.51 10.8 1.0 1.6 1 1 0 1 1 1 0 MerC mercury resistance protein Abhydrolase_6 PF12697.7 EEA23148.1 - 2.4e-13 51.2 0.0 3.2e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA23148.1 - 1.9e-06 27.7 0.0 4.3e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA23148.1 - 0.0066 15.7 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EEA23148.1 - 0.02 14.6 0.0 0.078 12.7 0.0 1.8 2 0 0 2 2 2 0 PGAP1-like protein Ser_hydrolase PF06821.13 EEA23148.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase NACHT_N PF17100.5 EEA23149.1 - 7.2e-38 130.6 8.3 6.6e-23 81.7 0.5 3.1 1 1 1 2 2 2 2 N-terminal domain of NWD NACHT-NTPase Trypan_glycop PF00913.19 EEA23149.1 - 0.055 12.7 0.6 3.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) DUF515 PF04415.12 EEA23149.1 - 0.075 11.4 0.3 0.23 9.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF515) 6PF2K PF01591.18 EEA23151.1 - 1.2e-67 227.5 0.0 8.6e-47 159.3 0.0 2.3 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EEA23151.1 - 1.4e-31 109.7 0.1 4e-24 85.4 0.0 3.2 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EEA23151.1 - 0.0001 22.5 0.1 0.1 12.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain KTI12 PF08433.10 EEA23151.1 - 0.011 15.3 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF202 PF02656.15 EEA23152.1 - 0.00043 20.7 2.2 0.00043 20.7 2.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) PQ-loop PF04193.14 EEA23153.1 - 2.2e-37 126.6 11.5 1.1e-18 66.7 1.8 2.5 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EEA23153.1 - 0.068 13.2 0.1 0.068 13.2 0.1 2.7 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange SOG2 PF10428.9 EEA23154.1 - 0.23 10.6 15.2 0.29 10.3 15.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SWI-SNF_Ssr4 PF08549.10 EEA23154.1 - 1.2 7.7 3.9 1.5 7.4 3.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Hamartin PF04388.12 EEA23154.1 - 1.8 7.1 8.1 2.1 6.9 8.1 1.1 1 0 0 1 1 1 0 Hamartin protein Apt1 PF10351.9 EEA23154.1 - 3.5 6.4 6.9 4.3 6.1 6.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EEA23154.1 - 9.1 4.7 9.8 12 4.4 9.8 1.1 1 0 0 1 1 1 0 Macoilin family GLEYA PF10528.9 EEA23155.1 - 5.2e-18 65.3 2.1 5.2e-18 65.3 2.1 2.1 2 0 0 2 2 2 1 GLEYA domain PA14 PF07691.12 EEA23155.1 - 0.00011 22.1 0.9 0.00026 20.8 0.9 1.7 1 0 0 1 1 1 1 PA14 domain PNP_UDP_1 PF01048.20 EEA23156.1 - 1.7e-10 40.6 0.6 1.3e-09 37.7 0.6 2.2 1 1 0 1 1 1 1 Phosphorylase superfamily NB-ARC PF00931.22 EEA23156.1 - 3.9e-09 36.1 0.0 9.4e-09 34.8 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 EEA23156.1 - 0.00081 19.8 0.8 0.013 15.9 0.0 3.0 1 1 1 3 3 3 1 AAA ATPase domain Glyco_hydro_7 PF00840.20 EEA23157.1 - 7.6e-196 651.0 12.6 1.1e-195 650.5 12.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 CBM_1 PF00734.18 EEA23157.1 - 4.1e-14 52.2 12.0 4.1e-14 52.2 12.0 4.1 4 0 0 4 4 4 1 Fungal cellulose binding domain Toxin_7 PF05980.12 EEA23157.1 - 0.37 11.1 4.9 0.36 11.1 1.6 2.6 2 0 0 2 2 2 0 Toxin 7 Glyco_hydro_28 PF00295.17 EEA23159.1 - 5.9e-124 413.4 21.7 7e-124 413.1 21.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Rick_17kDa_Anti PF05433.15 EEA23160.1 - 2.7e-05 23.9 8.5 2.7e-05 23.9 8.5 2.4 2 0 0 2 2 2 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EEA23160.1 - 0.0074 16.3 5.1 0.0074 16.3 5.1 2.4 3 0 0 3 3 3 1 Glycine zipper DUF533 PF04391.12 EEA23160.1 - 0.017 14.7 0.3 0.017 14.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF533) TraT PF05818.12 EEA23160.1 - 1.2 8.8 3.9 0.89 9.2 1.9 1.8 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein SH3_1 PF00018.28 EEA23161.1 - 7.9e-06 25.4 0.0 1.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EEA23161.1 - 0.0071 16.2 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_16 PF18348.1 EEA23161.1 - 0.011 15.5 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain Inhibitor_Mig-6 PF11555.8 EEA23161.1 - 0.033 14.3 4.2 0.046 13.8 1.8 2.5 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 DDE_3 PF13358.6 EEA23162.1 - 7.3e-12 45.3 0.2 2.1e-11 43.8 0.2 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA23162.1 - 6.3e-10 39.2 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA23162.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA23162.1 - 0.0077 16.2 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA23162.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA23162.1 - 0.0093 16.4 0.1 13 6.3 0.0 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA23162.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA23162.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA23162.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA23162.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA23162.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 Pkinase PF00069.25 EEA23163.1 - 3.1e-47 161.2 0.0 4.2e-47 160.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23163.1 - 1.3e-24 86.9 0.0 4.9e-21 75.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA23163.1 - 0.0041 15.9 0.0 0.0073 15.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EEA23163.1 - 0.12 12.3 0.2 0.51 10.2 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L27A PF00828.19 EEA23164.1 - 4.5e-31 108.2 0.1 7e-31 107.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A PIG-Y PF15159.6 EEA23165.1 - 1.6e-21 77.0 8.2 2.5e-21 76.3 8.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1218 PF06749.12 EEA23165.1 - 0.8 10.3 3.5 25 5.5 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) SelP_N PF04592.14 EEA23165.1 - 3.1 7.1 7.9 5.6 6.3 5.6 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region GATase_4 PF13230.6 EEA23166.1 - 1.3e-14 53.7 0.0 8.4e-13 47.8 0.0 2.3 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 EEA23166.1 - 1.8e-07 31.4 0.0 3e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EEA23167.1 - 1.3e-14 53.7 0.0 8.4e-13 47.8 0.0 2.3 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 EEA23167.1 - 1.8e-07 31.4 0.0 3e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Dynamin_N PF00350.23 EEA23168.1 - 5.4e-45 153.5 0.0 1.2e-44 152.4 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EEA23168.1 - 1.6e-17 63.7 0.0 3.7e-14 52.6 0.0 2.5 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EEA23168.1 - 2.2e-05 24.5 0.0 0.00033 20.7 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EEA23168.1 - 0.035 13.8 0.3 0.21 11.3 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 EEA23168.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Se-cys_synth_N PF12390.8 EEA23168.1 - 0.072 13.3 0.0 0.26 11.5 0.0 2.0 1 0 0 1 1 1 0 Selenocysteine synthase N terminal AAA_16 PF13191.6 EEA23168.1 - 0.096 13.1 0.0 0.44 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Cyclin PF08613.11 EEA23169.1 - 2e-14 54.3 0.0 3.8e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EEA23169.1 - 0.0048 16.7 0.0 0.0079 15.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pyr_redox_2 PF07992.14 EEA23170.1 - 7.3e-53 179.7 0.0 9.3e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA23170.1 - 2.2e-11 44.1 0.0 2e-10 41.1 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA23170.1 - 0.00088 18.6 0.1 0.62 9.3 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase COX14 PF14880.6 EEA23170.1 - 0.0013 18.6 1.7 0.0061 16.4 1.7 2.2 1 0 0 1 1 1 1 Cytochrome oxidase c assembly UPF0193 PF05250.11 EEA23170.1 - 0.018 14.9 0.2 0.018 14.9 0.2 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0193) SAPIS-gp6 PF16722.5 EEA23171.1 - 0.14 12.6 3.4 0.81 10.1 0.9 2.5 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus rRNA_processing PF08524.11 EEA23171.1 - 3.4 7.7 8.9 13 5.8 8.9 2.1 1 1 0 1 1 1 0 rRNA processing CPSF100_C PF13299.6 EEA23171.1 - 7.1 6.8 9.3 0.11 12.7 0.7 2.2 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal GTP_EFTU PF00009.27 EEA23172.1 - 4.2e-57 192.8 0.1 5.5e-57 192.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EEA23172.1 - 3.6e-21 75.6 0.0 8.2e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EEA23172.1 - 5.1e-18 65.2 0.7 1.4e-17 63.9 0.7 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA23172.1 - 6.9e-06 26.1 0.1 1.6e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA23172.1 - 0.0013 18.7 0.2 0.0054 16.7 0.1 2.0 1 1 1 2 2 2 1 RsgA GTPase cobW PF02492.19 EEA23172.1 - 0.023 14.3 0.5 0.24 11.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EEA23172.1 - 0.033 13.9 0.2 6.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IF3_N PF05198.16 EEA23173.1 - 6.8e-12 45.5 0.2 1.3e-11 44.6 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 EEA23173.1 - 7.2e-08 32.3 0.7 1.1e-07 31.7 0.7 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 EEA23173.1 - 2.5e-06 27.3 0.4 4.6e-06 26.4 0.4 1.5 1 1 0 1 1 1 1 Mitochondrial translation initiation factor SAVED PF18145.1 EEA23173.1 - 0.035 13.9 0.4 0.052 13.4 0.4 1.3 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain DUF2175 PF09943.9 EEA23173.1 - 0.27 11.5 5.1 0.22 11.8 0.9 2.2 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) GDA1_CD39 PF01150.17 EEA23174.1 - 3.2e-101 339.0 0.0 4.4e-101 338.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DDE_3 PF13358.6 EEA23175.1 - 7.3e-12 45.3 0.2 2.1e-11 43.8 0.2 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA23175.1 - 6.3e-10 39.2 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA23175.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA23175.1 - 0.0077 16.2 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA23175.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA23175.1 - 0.0093 16.4 0.1 13 6.3 0.0 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA23175.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA23175.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA23175.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA23175.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA23175.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 DUF4598 PF15370.6 EEA23176.1 - 3.9e-26 91.7 6.4 3.9e-26 91.7 6.4 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4598) Tim54 PF11711.8 EEA23176.1 - 1.3 7.7 7.2 0.13 11.0 2.5 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 IF4E PF01652.18 EEA23177.1 - 2.2e-31 108.8 0.2 3e-31 108.4 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E COMPASS-Shg1 PF05205.12 EEA23178.1 - 1.3e-26 93.3 0.6 1.3e-26 93.3 0.6 1.9 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 Cation_efflux PF01545.21 EEA23180.1 - 1.3e-15 57.7 10.6 1.7e-15 57.3 10.6 1.1 1 0 0 1 1 1 1 Cation efflux family zf-RING_2 PF13639.6 EEA23181.1 - 3e-08 33.9 6.9 5.8e-08 32.9 2.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EEA23181.1 - 1.3e-07 31.7 4.6 4e-07 30.2 4.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EEA23181.1 - 7.1e-07 29.0 6.9 2.6e-06 27.2 2.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA23181.1 - 1.7e-06 27.8 1.4 2.9e-06 27.0 1.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA23181.1 - 1.8e-06 27.8 2.2 4.7e-06 26.5 2.2 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA23181.1 - 0.00015 21.6 1.5 0.00015 21.6 1.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA23181.1 - 0.00018 21.3 1.1 0.00018 21.3 1.1 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EEA23181.1 - 0.00018 21.1 9.5 0.0031 17.2 0.2 3.3 3 0 0 3 3 3 2 RING-like zinc finger zf-RING_UBOX PF13445.6 EEA23181.1 - 0.0013 18.7 5.8 0.0017 18.3 1.7 2.9 1 1 1 2 2 2 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EEA23181.1 - 0.005 16.4 0.6 0.005 16.4 0.6 1.6 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EEA23181.1 - 0.0069 16.4 0.7 0.015 15.3 0.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF5337 PF17272.2 EEA23181.1 - 0.33 10.8 2.3 0.86 9.5 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5337) DUF2921 PF11145.8 EEA23181.1 - 0.34 8.7 0.3 0.49 8.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) RINGv PF12906.7 EEA23181.1 - 8.7 6.6 7.0 0.7 10.1 1.8 1.8 2 0 0 2 2 2 0 RING-variant domain GCV_H PF01597.19 EEA23182.1 - 2.9e-41 140.2 0.6 3.5e-41 139.9 0.6 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 EEA23182.1 - 0.1 12.5 0.3 0.48 10.3 0.2 2.0 1 1 1 2 2 2 0 Biotin-requiring enzyme Ribosomal_S6 PF01250.17 EEA23183.1 - 1.9e-23 82.6 0.0 2.4e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Lactamase_B PF00753.27 EEA23186.1 - 3.1e-06 27.3 0.1 7.8e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA23186.1 - 0.0023 17.5 0.2 0.0048 16.4 0.2 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EEA23186.1 - 0.12 12.3 0.1 0.32 10.9 0.1 1.7 1 1 0 1 1 1 0 Beta-lactamase superfamily domain NAD_binding_2 PF03446.15 EEA23187.1 - 8.1e-31 107.3 0.5 1.4e-30 106.6 0.5 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA23187.1 - 3.6e-25 88.6 0.0 6.6e-25 87.7 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Glyco_hydro_4 PF02056.16 EEA23187.1 - 7e-06 25.7 0.1 0.00028 20.5 0.0 2.2 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase IlvN PF07991.12 EEA23187.1 - 0.0011 18.6 0.1 0.0021 17.6 0.1 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain OCD_Mu_crystall PF02423.15 EEA23187.1 - 0.0059 15.6 0.1 0.0092 14.9 0.1 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.17 EEA23187.1 - 0.019 15.5 0.1 0.061 13.9 0.0 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ADH_N PF08240.12 EEA23188.1 - 5.8e-19 68.0 0.8 1.4e-18 66.7 0.8 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA23188.1 - 1.8e-13 50.6 0.0 2.9e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_32 PF13679.6 EEA23188.1 - 0.022 14.7 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EEA23188.1 - 0.028 15.1 0.1 0.081 13.6 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EEA23188.1 - 0.038 13.8 0.1 0.092 12.5 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EEA23188.1 - 0.06 14.1 0.0 0.14 12.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Fungal_trans PF04082.18 EEA23189.1 - 2.9e-11 42.9 0.1 3.1e-06 26.4 0.1 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA23189.1 - 1.5e-08 34.6 12.3 0.0011 19.3 0.6 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA23189.1 - 1.1e-06 28.8 1.6 1.1e-06 28.8 1.6 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA23189.1 - 1.4e-05 25.5 11.1 0.019 15.8 4.5 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EEA23189.1 - 0.1 13.2 4.5 1.1 9.9 0.6 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 EEA23189.1 - 0.55 10.6 3.0 5 7.5 1.4 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EEA23189.1 - 0.69 10.4 7.0 4.6 7.8 2.4 2.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger CMD PF02627.20 EEA23190.1 - 1.6e-21 76.1 0.1 2.6e-21 75.4 0.1 1.3 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family TFX_C PF14601.6 EEA23190.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.5 1 1 0 1 1 1 0 DNA_binding protein, TFX, C-term NAD_binding_2 PF03446.15 EEA23191.1 - 7.8e-33 113.9 0.0 1.1e-32 113.4 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA23191.1 - 2.5e-21 76.2 0.0 4.3e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 EEA23191.1 - 0.0079 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EEA23191.1 - 0.024 15.2 0.0 0.051 14.2 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EEA23191.1 - 0.057 13.5 0.0 0.086 12.9 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EEA23191.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PTR2 PF00854.21 EEA23194.1 - 5.2e-80 269.2 8.1 1.7e-79 267.5 8.1 1.7 1 1 0 1 1 1 1 POT family CMD PF02627.20 EEA23195.1 - 1.7e-15 56.8 0.0 5.4e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 Carboxymuconolactone decarboxylase family A_thal_3526 PF09713.10 EEA23195.1 - 2.7 8.3 5.0 12 6.2 1.0 3.4 4 0 0 4 4 4 0 Plant protein 1589 of unknown function (A_thal_3526) MFS_1 PF07690.16 EEA23196.1 - 4.6e-29 101.5 15.6 4.6e-29 101.5 15.6 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily FAD_binding_4 PF01565.23 EEA23197.1 - 3.1e-21 75.6 1.3 5.6e-21 74.7 1.3 1.5 1 0 0 1 1 1 1 FAD binding domain DUF3124 PF11322.8 EEA23197.1 - 0.042 14.0 0.3 0.26 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3124) p450 PF00067.22 EEA23199.1 - 5.1e-37 127.7 0.0 7.4e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EEA23200.1 - 6.4e-19 68.2 0.0 1.9e-14 53.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EEA23200.1 - 9.5e-06 25.6 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA23200.1 - 0.023 14.2 0.0 0.12 11.8 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family p450 PF00067.22 EEA23201.1 - 9.1e-34 117.0 0.0 2.2e-33 115.7 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 p450 PF00067.22 EEA23202.1 - 2.7e-48 164.9 0.0 3.6e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 EEA23203.1 - 2.3e-24 85.7 2.1 5.1e-24 84.6 2.1 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA23203.1 - 0.00044 20.3 0.0 0.00092 19.3 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 EEA23204.1 - 1.8e-22 79.5 0.1 4.1e-22 78.4 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain CoA_binding_2 PF13380.6 EEA23204.1 - 0.083 13.4 0.1 0.2 12.2 0.1 1.6 1 0 0 1 1 1 0 CoA binding domain Chs7 PF12271.8 EEA23205.1 - 3e-120 400.9 11.8 3.5e-120 400.7 11.8 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone UPF0242 PF06785.11 EEA23205.1 - 1.2 9.2 2.3 3.7 7.6 2.3 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Abhydrolase_6 PF12697.7 EEA23206.1 - 4.2e-05 24.3 2.4 6.9e-05 23.6 1.6 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EEA23206.1 - 5e-05 22.9 0.0 7.1e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EEA23206.1 - 0.0013 18.5 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 EEA23206.1 - 0.0081 15.4 0.0 0.016 14.4 0.0 1.4 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EEA23206.1 - 0.037 13.3 0.2 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA23206.1 - 0.069 12.8 0.2 0.14 11.8 0.1 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF900 PF05990.12 EEA23206.1 - 0.12 11.8 0.1 0.79 9.2 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_2 PF02230.16 EEA23206.1 - 0.16 11.7 0.1 6.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Acetyltransf_10 PF13673.7 EEA23207.1 - 1.8e-10 40.9 0.0 3.5e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA23207.1 - 1.4e-09 38.2 0.0 5.5e-09 36.3 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA23207.1 - 4.1e-09 36.7 0.0 6.4e-09 36.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EEA23207.1 - 0.00016 21.8 0.0 0.013 15.6 0.0 2.6 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA23207.1 - 0.00018 21.6 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EEA23207.1 - 0.0015 18.5 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein DUF5421 PF17458.2 EEA23207.1 - 0.0082 15.6 1.0 0.0082 15.6 1.0 1.5 2 0 0 2 2 2 1 Family of unknown function (DUF5421) Arrestin_C PF02752.22 EEA23208.1 - 9.8e-20 71.4 0.0 6.3e-18 65.5 0.0 3.0 3 1 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EEA23208.1 - 7e-11 42.4 0.1 1.2e-05 25.5 0.0 2.4 1 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Acetyltransf_4 PF13420.7 EEA23209.1 - 0.015 15.4 0.0 0.032 14.4 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain RRM_1 PF00076.22 EEA23212.1 - 2.2e-59 197.2 0.0 7.6e-21 73.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA23212.1 - 2.7e-07 30.4 0.0 0.0052 16.6 0.0 2.9 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EEA23212.1 - 4.1e-07 29.6 0.0 0.00036 20.1 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA23212.1 - 0.00067 19.7 0.1 0.99 9.6 0.0 3.4 3 1 0 3 3 3 2 RNA recognition motif RRM_8 PF11835.8 EEA23212.1 - 0.00087 19.4 0.0 1.6 9.0 0.0 2.5 2 0 0 2 2 2 2 RRM-like domain Cas_Cas2CT1978 PF09707.10 EEA23212.1 - 0.0029 17.6 0.0 0.48 10.5 0.0 2.5 2 0 0 2 2 2 1 CRISPR-associated protein (Cas_Cas2CT1978) Nup35_RRM_2 PF14605.6 EEA23212.1 - 0.0049 16.9 0.1 2.9 8.0 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EEA23212.1 - 0.011 15.7 0.1 40 4.2 0.0 3.2 2 1 1 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EEA23212.1 - 0.077 13.0 0.1 3 7.9 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif Limkain-b1 PF11608.8 EEA23212.1 - 0.11 12.6 0.1 34 4.6 0.0 3.3 3 1 0 3 3 3 0 Limkain b1 RRM_1 PF00076.22 EEA23213.1 - 1.3e-59 197.9 0.0 6.2e-21 74.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA23213.1 - 1.6e-07 31.0 0.0 0.0043 16.9 0.0 3.0 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EEA23213.1 - 2.5e-07 30.3 0.0 0.0003 20.4 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA23213.1 - 0.00041 20.4 0.1 0.81 9.8 0.0 3.4 3 1 0 3 3 3 2 RNA recognition motif RRM_8 PF11835.8 EEA23213.1 - 0.00058 20.0 0.0 1.3 9.3 0.0 2.5 3 0 0 3 3 2 2 RRM-like domain Cas_Cas2CT1978 PF09707.10 EEA23213.1 - 0.002 18.1 0.0 0.4 10.8 0.0 2.5 2 0 0 2 2 2 1 CRISPR-associated protein (Cas_Cas2CT1978) Nup35_RRM_2 PF14605.6 EEA23213.1 - 0.003 17.5 0.1 2.4 8.2 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EEA23213.1 - 0.0068 16.4 0.1 33 4.5 0.0 3.2 2 1 1 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EEA23213.1 - 0.054 13.5 0.1 2.4 8.2 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif Limkain-b1 PF11608.8 EEA23213.1 - 0.067 13.3 0.1 29 4.8 0.0 3.3 3 1 0 3 3 3 0 Limkain b1 RNA_bind PF08675.11 EEA23213.1 - 0.085 12.9 0.1 14 5.8 0.0 2.6 2 0 0 2 2 2 0 RNA binding domain SET_assoc PF11767.8 EEA23213.1 - 0.15 11.7 0.0 24 4.7 0.0 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated MFS_1 PF07690.16 EEA23214.1 - 1.5e-41 142.5 44.7 1.5e-41 142.5 44.7 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23214.1 - 2.7e-10 39.7 36.3 5.2e-10 38.8 5.6 3.2 2 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EEA23214.1 - 1.4e-09 37.0 23.8 3e-09 35.9 23.8 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3377 PF11857.8 EEA23214.1 - 0.15 12.0 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) CrgA PF06781.12 EEA23214.1 - 0.18 11.9 3.5 24 5.0 0.6 3.8 3 0 0 3 3 3 0 Cell division protein CrgA Zn_clus PF00172.18 EEA23215.1 - 4.4e-06 26.7 10.2 9.3e-06 25.7 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain L31 PF09784.9 EEA23215.1 - 0.051 14.0 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 Fungal_trans PF04082.18 EEA23215.1 - 0.066 12.2 0.1 0.22 10.5 0.1 1.9 1 1 0 1 1 1 0 Fungal specific transcription factor domain HRI1 PF16815.5 EEA23216.1 - 4.6e-39 134.5 1.3 5.3e-39 134.3 1.3 1.0 1 0 0 1 1 1 1 Protein HRI1 Fungal_trans_2 PF11951.8 EEA23217.1 - 6.6e-46 156.8 0.9 8.3e-46 156.5 0.9 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23217.1 - 1.6e-06 28.1 11.1 1.6e-06 28.1 11.1 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RHD3 PF05879.12 EEA23218.1 - 0 1064.5 0.0 0 1064.2 0.0 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) p450 PF00067.22 EEA23218.1 - 1.6e-52 178.8 0.1 5.4e-52 177.1 0.0 1.8 2 0 0 2 2 2 1 Cytochrome P450 GBP PF02263.19 EEA23218.1 - 1.6e-07 30.9 0.2 3.3e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EEA23218.1 - 9.2e-06 25.8 0.0 1.9e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EEA23218.1 - 0.00021 21.3 0.0 0.00046 20.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EEA23218.1 - 0.013 14.8 0.0 0.069 12.4 0.1 2.0 2 0 0 2 2 2 0 Septin AAA_28 PF13521.6 EEA23218.1 - 0.017 15.4 0.7 0.048 13.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF5442 PF17514.2 EEA23218.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5442) V-SNARE PF05008.15 EEA23218.1 - 0.91 9.9 4.1 0.39 11.1 0.6 2.2 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus MFS_1 PF07690.16 EEA23219.1 - 2.2e-33 115.7 15.0 5.2e-24 84.8 1.5 3.3 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23219.1 - 1.2e-12 47.4 2.0 1.2e-12 47.4 2.0 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EEA23219.1 - 6.5e-06 24.8 0.3 9e-06 24.4 0.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EEA23219.1 - 0.0064 14.8 0.4 2 6.6 0.1 2.3 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Fungal_trans_2 PF11951.8 EEA23220.1 - 6.6e-19 68.0 0.0 7.1e-19 67.9 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 EEA23221.1 - 6.7e-18 64.6 0.9 7.6e-18 64.5 0.9 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cyclase PF04199.13 EEA23222.1 - 9.6e-12 45.3 0.0 2.2e-11 44.1 0.0 1.4 1 1 1 2 2 2 1 Putative cyclase Cupin_3 PF05899.12 EEA23222.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) HMG_box_2 PF09011.10 EEA23222.1 - 0.064 13.9 0.2 0.17 12.5 0.1 1.7 2 0 0 2 2 2 0 HMG-box domain DUF5490 PF17593.2 EEA23222.1 - 0.1 12.6 0.1 0.26 11.3 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5490) Dynamin_M PF01031.20 EEA23223.1 - 4.6e-37 127.8 0.2 1.3e-36 126.3 0.2 1.7 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EEA23223.1 - 1.5e-27 96.7 0.3 3.4e-27 95.5 0.0 1.8 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EEA23223.1 - 1.2e-05 25.4 0.2 8.6e-05 22.6 0.1 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EEA23223.1 - 2.2e-05 23.9 0.4 0.087 12.1 0.0 2.7 2 0 0 2 2 2 2 AIG1 family GTP_EFTU PF00009.27 EEA23223.1 - 0.011 15.3 1.0 0.47 10.0 0.2 2.7 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain GED PF02212.18 EEA23223.1 - 0.015 15.4 0.6 0.051 13.7 0.1 2.2 2 0 0 2 2 2 0 Dynamin GTPase effector domain AAA_15 PF13175.6 EEA23223.1 - 0.022 14.5 0.2 0.073 12.8 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain IF3_N PF05198.16 EEA23223.1 - 0.053 13.8 0.1 4.1 7.8 0.0 2.5 2 0 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain Roc PF08477.13 EEA23223.1 - 0.055 13.7 0.0 1.4 9.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RBD-FIP PF09457.10 EEA23223.1 - 0.42 10.6 4.4 4.9 7.2 0.1 3.1 3 0 0 3 3 3 0 FIP domain 4HBT_2 PF13279.6 EEA23224.1 - 7e-06 26.5 0.0 1.4e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Thioesterase-like superfamily HIG_1_N PF04588.13 EEA23225.1 - 5.1e-08 33.0 0.1 5.1e-08 33.0 0.1 2.1 2 0 0 2 2 2 1 Hypoxia induced protein conserved region DUF3683 PF12447.8 EEA23225.1 - 0.017 15.2 0.1 0.058 13.5 0.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3683) HSP70 PF00012.20 EEA23225.1 - 0.24 9.5 9.4 0.31 9.2 9.4 1.1 1 0 0 1 1 1 0 Hsp70 protein Med26 PF08711.11 EEA23226.1 - 2e-09 37.3 0.0 4.5e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Tox-SHH PF15652.6 EEA23226.1 - 0.42 11.6 2.1 0.72 10.8 0.6 2.2 2 0 0 2 2 2 0 HNH/Endo VII superfamily toxin with a SHH signature Nup54 PF13874.6 EEA23227.1 - 9.7e-41 139.2 0.0 9.7e-41 139.2 0.0 2.3 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 EEA23227.1 - 2.9e-25 88.9 70.5 9.4e-14 52.0 32.9 3.3 2 1 1 3 3 3 2 Nucleoporin FG repeat region Nup54_57_C PF18570.1 EEA23227.1 - 1.2e-09 37.6 0.8 2.3e-09 36.7 0.8 1.5 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain V-SNARE_C PF12352.8 EEA23227.1 - 0.09 13.1 0.4 2.7 8.4 0.1 2.6 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Prefoldin PF02996.17 EEA23227.1 - 2.2 8.2 7.1 0.58 10.1 0.8 2.6 3 0 0 3 3 3 0 Prefoldin subunit TMF_DNA_bd PF12329.8 EEA23227.1 - 2.7 8.1 6.6 0.38 10.8 1.2 2.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Suf PF05843.14 EEA23227.1 - 4.7 7.1 6.0 8.1 6.3 6.0 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CX9C PF16860.5 EEA23228.1 - 0.0002 21.3 8.8 0.0027 17.7 4.0 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EEA23228.1 - 0.00051 20.1 14.7 0.0029 17.7 5.3 2.6 3 0 0 3 3 3 2 CHCH domain Pet191_N PF10203.9 EEA23228.1 - 0.018 15.4 7.9 5.3 7.4 4.6 3.0 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 EEA23228.1 - 0.12 12.6 10.6 1.2 9.5 3.0 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Cmc1 PF08583.10 EEA23228.1 - 1 9.4 12.8 4.2 7.5 1.7 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like 4HBT PF03061.22 EEA23229.1 - 1.5e-09 38.0 0.0 2.1e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Bul1_C PF04426.12 EEA23230.1 - 0.021 14.2 0.5 0.043 13.2 0.5 1.5 1 0 0 1 1 1 0 Bul1 C terminus Glutaredoxin2_C PF04399.13 EEA23230.1 - 0.035 13.9 0.1 0.36 10.7 0.0 2.3 2 1 0 2 2 2 0 Glutaredoxin 2, C terminal domain bZIP_1 PF00170.21 EEA23230.1 - 0.22 11.7 1.2 7.5 6.7 0.2 2.7 2 0 0 2 2 2 0 bZIP transcription factor TSC22 PF01166.18 EEA23230.1 - 0.83 10.0 6.2 3.7 7.9 0.3 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family SlyX PF04102.12 EEA23230.1 - 5.1 7.8 17.7 19 6.0 0.1 3.5 2 1 1 3 3 3 0 SlyX Cpn60_TCP1 PF00118.24 EEA23231.1 - 7.9e-87 291.9 13.5 2.1e-86 290.5 13.5 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Myb_DNA-binding PF00249.31 EEA23232.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain ATP-synt_Eps PF04627.13 EEA23233.1 - 3.8e-22 78.0 2.1 4.8e-22 77.7 2.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Mak10 PF04112.13 EEA23234.1 - 7.1e-67 224.1 0.2 1.2e-66 223.4 0.2 1.4 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase adh_short PF00106.25 EEA23235.1 - 0.051 13.0 0.1 0.08 12.4 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23235.1 - 0.063 12.8 0.0 0.09 12.3 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Fungal_trans PF04082.18 EEA23236.1 - 3.2e-13 49.3 0.1 7.8e-13 48.1 0.0 1.7 1 1 1 2 2 2 1 Fungal specific transcription factor domain CAP PF00188.26 EEA23237.1 - 1.1e-16 61.8 1.1 1.7e-16 61.2 1.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PXPV PF12778.7 EEA23237.1 - 0.16 11.8 0.4 0.16 11.8 0.4 2.3 2 0 0 2 2 2 0 PXPV repeat (3 copies) Fe-ADH PF00465.19 EEA23238.1 - 2.5e-06 26.6 0.0 2.6e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DUF4925 PF16272.5 EEA23238.1 - 0.024 14.1 0.0 0.027 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4925) T4_Rnl2_C PF18043.1 EEA23238.1 - 0.082 13.1 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal GST_N_4 PF17172.4 EEA23239.1 - 0.11 13.3 0.0 0.17 12.6 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Thioredox_DsbH PF03190.15 EEA23240.1 - 6.2e-71 237.6 0.0 1.3e-70 236.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EEA23240.1 - 1.1e-05 25.6 0.0 2.5e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_9 PF00759.19 EEA23240.1 - 0.00088 18.8 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Glyco_hydro_88 PF07470.13 EEA23240.1 - 0.0031 16.6 0.0 0.8 8.7 0.1 2.9 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 EEA23240.1 - 0.036 13.6 0.0 0.097 12.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 76 Mrr_N PF14338.6 EEA23240.1 - 0.064 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Mrr N-terminal domain Sigma70_r4 PF04545.16 EEA23240.1 - 0.18 11.3 0.0 0.43 10.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 WD40 PF00400.32 EEA23241.1 - 7.5e-21 74.1 7.4 2.3e-06 28.2 0.2 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA23241.1 - 0.00052 20.3 0.0 0.36 11.1 0.0 3.5 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Reg_prop PF07494.11 EEA23241.1 - 0.053 13.7 0.0 1.2 9.6 0.0 2.9 2 0 0 2 2 2 0 Two component regulator propeller Nup160 PF11715.8 EEA23241.1 - 0.058 12.0 0.1 0.87 8.1 0.0 2.6 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Sigma70_r1_2 PF00140.20 EEA23241.1 - 0.11 12.6 0.7 0.23 11.5 0.7 1.6 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 LSM14 PF12701.7 EEA23242.1 - 9.4e-28 96.1 0.1 1.6e-27 95.4 0.1 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EEA23242.1 - 1.4e-18 67.7 4.2 2.8e-18 66.7 4.2 1.5 1 0 0 1 1 1 1 FDF domain SM-ATX PF14438.6 EEA23242.1 - 1.8e-06 28.0 0.0 3.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 EEA23242.1 - 0.19 11.4 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 LSM domain GRP PF07172.11 EEA23242.1 - 1.4 9.7 18.1 0.72 10.6 13.5 2.4 2 0 0 2 2 2 0 Glycine rich protein family ACBP PF00887.19 EEA23243.1 - 1.8e-21 76.1 0.0 3.3e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein CDC45 PF02724.14 EEA23243.1 - 9.7e-06 24.2 5.1 1.4e-05 23.7 5.1 1.2 1 0 0 1 1 1 1 CDC45-like protein RRN3 PF05327.11 EEA23243.1 - 0.0066 15.1 3.1 0.0095 14.5 3.1 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Nop53 PF07767.11 EEA23243.1 - 0.021 14.2 8.2 0.033 13.6 8.2 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) NOA36 PF06524.12 EEA23243.1 - 0.041 13.2 7.0 0.066 12.5 7.0 1.3 1 0 0 1 1 1 0 NOA36 protein Hid1 PF12722.7 EEA23243.1 - 0.076 11.1 3.2 0.085 11.0 3.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Tnp_DNA_bind PF14706.6 EEA23243.1 - 0.13 12.2 1.0 0.41 10.5 1.0 1.8 1 0 0 1 1 1 0 Transposase DNA-binding Baculo_F PF12259.8 EEA23243.1 - 0.22 10.0 0.1 0.3 9.5 0.1 1.1 1 0 0 1 1 1 0 Baculovirus F protein Sporozoite_P67 PF05642.11 EEA23243.1 - 1.5 6.8 4.0 1.9 6.5 4.0 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen GST_N_2 PF13409.6 EEA23245.1 - 4.6e-18 65.3 0.0 1.7e-17 63.5 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA23245.1 - 1.5e-17 63.7 0.0 2.8e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA23245.1 - 1.2e-16 60.8 0.1 3.3e-16 59.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EEA23245.1 - 9.1e-06 25.8 0.0 1.5e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 EEA23246.1 - 5.4e-18 65.1 0.0 8e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA23246.1 - 8.2e-18 64.6 0.0 1.3e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA23246.1 - 8.5e-17 61.3 0.0 1.5e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EEA23246.1 - 4.9e-06 26.7 0.0 7.3e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Cofilin_ADF PF00241.20 EEA23247.1 - 1.6e-33 115.0 0.1 1.9e-33 114.9 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein COX4 PF02936.14 EEA23248.1 - 1.5e-43 148.1 0.6 1.8e-43 147.8 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF3106 PF11304.8 EEA23248.1 - 0.18 12.3 4.5 0.074 13.5 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) ATP-synt_ab PF00006.25 EEA23249.1 - 1.1e-61 208.2 0.0 1.9e-61 207.4 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EEA23249.1 - 8.3e-24 83.9 0.2 3.7e-23 81.8 0.1 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 EEA23249.1 - 0.0041 16.5 0.2 0.0068 15.8 0.2 1.4 1 0 0 1 1 1 1 KaiC AAA PF00004.29 EEA23249.1 - 0.015 15.7 0.1 0.81 10.1 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EEA23249.1 - 0.019 14.9 0.4 0.043 13.7 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase NB-ARC PF00931.22 EEA23249.1 - 0.019 14.2 0.3 0.11 11.7 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.6 EEA23249.1 - 0.042 14.2 1.1 0.48 10.7 0.2 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EEA23249.1 - 0.043 13.7 0.0 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EEA23249.1 - 0.056 13.3 0.2 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 EEA23249.1 - 0.1 13.0 0.1 0.49 10.7 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EEA23249.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase T3SS_ATPase_C PF18269.1 EEA23249.1 - 0.1 12.5 0.8 0.43 10.5 0.8 1.9 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain 3Beta_HSD PF01073.19 EEA23250.1 - 6.6e-40 136.9 0.0 9e-40 136.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA23250.1 - 1.5e-21 77.0 0.0 2.3e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA23250.1 - 6.6e-14 51.7 0.4 5.5e-13 48.7 0.4 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EEA23250.1 - 3.1e-13 49.9 0.0 2.4e-12 46.9 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EEA23250.1 - 4.1e-11 42.6 0.0 5.6e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA23250.1 - 3.3e-08 33.0 0.0 5.1e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EEA23250.1 - 4.9e-06 26.1 0.0 0.00018 21.1 0.0 2.7 2 1 1 3 3 3 1 short chain dehydrogenase KR PF08659.10 EEA23250.1 - 6.6e-06 26.1 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EEA23250.1 - 0.00035 20.8 0.0 0.0006 20.1 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Pentapeptide_4 PF13599.6 EEA23251.1 - 0.0082 16.3 0.0 0.32 11.2 0.0 2.6 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_1 PF07690.16 EEA23252.1 - 8.8e-34 117.0 37.3 3.9e-32 111.6 38.8 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Chordopox_L2 PF05803.12 EEA23252.1 - 0.025 14.4 0.1 0.09 12.6 0.1 2.0 1 0 0 1 1 1 0 Chordopoxvirus L2 protein SH PF01445.17 EEA23252.1 - 0.053 13.5 0.7 0.25 11.4 0.0 2.5 2 0 0 2 2 2 0 Viral small hydrophobic protein DUF2627 PF11118.8 EEA23252.1 - 1.9 9.1 0.0 1.9 9.1 0.0 4.3 4 2 0 4 4 4 0 Protein of unknown function (DUF2627) Saf_2TM PF18303.1 EEA23252.1 - 2.3 7.8 0.0 2.3 7.8 0.0 4.1 4 1 0 4 4 4 0 SAVED-fused 2TM effector domain Fungal_trans_2 PF11951.8 EEA23253.1 - 2.7e-05 23.2 0.0 0.00017 20.5 0.0 2.2 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23253.1 - 3.8e-05 23.7 13.1 7.2e-05 22.8 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TSC22 PF01166.18 EEA23253.1 - 0.081 13.2 1.5 0.27 11.6 1.5 1.9 1 0 0 1 1 1 0 TSC-22/dip/bun family Lipase_2 PF01674.18 EEA23254.1 - 3.1e-06 26.9 0.0 9.1e-06 25.3 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 2) Abhydrolase_6 PF12697.7 EEA23254.1 - 0.00041 21.0 0.1 0.00062 20.4 0.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA23254.1 - 0.0064 16.2 0.1 0.065 12.9 0.0 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA23254.1 - 0.014 14.7 0.1 0.049 12.9 0.0 1.9 2 1 0 2 2 2 0 Serine aminopeptidase, S33 DUF900 PF05990.12 EEA23254.1 - 0.023 14.2 0.0 0.067 12.7 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) DUF1364 PF07102.12 EEA23254.1 - 0.029 14.2 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1364) GFA PF04828.14 EEA23255.1 - 2.4e-13 50.2 0.5 4e-13 49.5 0.5 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme ABC_tran PF00005.27 EEA23256.1 - 1.4e-42 145.5 0.0 9.1e-26 91.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA23256.1 - 5.9e-34 118.0 34.0 1.1e-22 81.0 16.1 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 EEA23256.1 - 8.4e-11 41.7 3.5 2.9e-05 23.6 1.3 4.2 2 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA23256.1 - 2e-07 31.4 0.4 0.011 16.1 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EEA23256.1 - 7.1e-07 29.3 0.3 1.1 9.0 0.0 4.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA23256.1 - 1.7e-05 24.8 0.2 0.06 13.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EEA23256.1 - 8.6e-05 22.2 2.4 0.062 13.1 0.5 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA23256.1 - 0.00012 22.5 1.5 0.76 10.1 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EEA23256.1 - 0.00016 21.8 0.0 0.56 10.3 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_25 PF13481.6 EEA23256.1 - 0.00023 20.8 0.3 0.017 14.7 0.1 3.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EEA23256.1 - 0.0013 18.9 0.2 1.8 8.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EEA23256.1 - 0.0068 16.9 0.0 4 7.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EEA23256.1 - 0.012 15.7 1.2 4.7 7.2 0.1 2.8 2 0 0 2 2 2 0 Dynamin family NACHT PF05729.12 EEA23256.1 - 0.017 15.0 0.3 8.9 6.2 0.2 2.6 2 0 0 2 2 2 0 NACHT domain DUF87 PF01935.17 EEA23256.1 - 0.019 15.1 1.5 0.056 13.5 0.2 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_15 PF13175.6 EEA23256.1 - 0.028 14.1 0.0 6.2 6.4 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 EEA23256.1 - 0.039 13.0 1.0 1.4 7.9 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 EEA23256.1 - 0.046 13.2 0.1 10 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 EEA23256.1 - 0.055 13.1 1.3 1.5 8.4 0.1 2.7 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.6 EEA23256.1 - 0.08 13.2 0.0 12 6.3 0.0 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 EEA23256.1 - 0.09 13.3 0.0 11 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA23256.1 - 0.17 11.6 1.0 45 3.7 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 EEA23256.1 - 0.34 10.2 1.1 6.2 6.1 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Glyoxalase_6 PF18029.1 EEA23257.1 - 0.00087 20.1 0.0 0.0019 18.9 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 EEA23257.1 - 0.0026 18.0 0.1 0.025 14.8 0.0 2.0 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MIP PF00230.20 EEA23258.1 - 8.3e-33 114.0 8.3 1.2e-32 113.4 8.3 1.3 1 0 0 1 1 1 1 Major intrinsic protein MFS_1 PF07690.16 EEA23259.1 - 1.3e-43 149.3 52.1 4e-43 147.7 50.3 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23259.1 - 5.3e-16 58.5 24.7 1.5e-12 47.1 11.7 2.8 3 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EEA23259.1 - 2.8e-15 55.8 17.0 2.8e-15 55.8 17.0 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.18 EEA23260.1 - 1.8e-06 28.0 10.9 3.1e-06 27.2 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2417 PF10329.9 EEA23260.1 - 0.14 11.5 0.3 0.28 10.6 0.3 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Glyco_hydro_71 PF03659.14 EEA23262.1 - 1.1e-94 317.3 6.1 1.3e-94 317.1 6.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Sporozoite_P67 PF05642.11 EEA23263.1 - 0.1 10.7 6.7 0.15 10.2 6.7 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DIOX_N PF14226.6 EEA23264.1 - 2.1e-30 105.9 0.0 3.4e-30 105.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA23264.1 - 7.7e-25 87.3 0.0 1.4e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 EEA23265.1 - 1.1e-05 25.4 9.1 2.2e-05 24.5 9.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA23265.1 - 1.9e-05 23.8 1.9 3.7e-05 22.9 1.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EEA23267.1 - 6.9e-34 117.3 46.3 4.4e-32 111.4 28.9 1.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Vma12 PF11712.8 EEA23267.1 - 0.51 10.4 3.2 10 6.2 0.2 2.7 2 1 1 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase MFS_1 PF07690.16 EEA23268.1 - 2.6e-28 98.9 44.3 2.7e-28 98.9 31.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23268.1 - 1.6e-10 40.5 16.8 3.3e-10 39.4 16.8 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter YMF19 PF02326.15 EEA23268.1 - 0.34 11.7 0.1 0.34 11.7 0.1 1.8 2 0 0 2 2 2 0 Plant ATP synthase F0 Fungal_trans_2 PF11951.8 EEA23269.1 - 4.6e-05 22.4 0.3 0.073 11.9 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Acetyltransf_7 PF13508.7 EEA23270.1 - 1.9e-05 25.0 0.0 2.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA23270.1 - 4.5e-05 23.7 0.0 6.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA23270.1 - 0.0003 20.7 0.0 0.00044 20.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA23270.1 - 0.16 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AA_permease_2 PF13520.6 EEA23271.1 - 4e-46 157.7 44.6 5.3e-46 157.3 44.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA23271.1 - 1.4e-16 60.2 44.0 4e-16 58.7 44.0 1.7 1 1 0 1 1 1 1 Amino acid permease YpmT PF17431.2 EEA23271.1 - 0.0017 18.3 1.2 0.0017 18.3 1.2 2.8 3 0 0 3 3 3 1 Uncharacterized YmpT-like PalH PF08733.10 EEA23272.1 - 0.99 8.3 19.6 1.5 7.8 19.6 1.3 1 1 0 1 1 1 0 PalH/RIM21 DUF3112 PF11309.8 EEA23272.1 - 2.2 7.7 12.6 0.024 14.1 2.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3112) p450 PF00067.22 EEA23273.1 - 1.5e-58 198.7 0.0 1.9e-58 198.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MASE2 PF05230.11 EEA23273.1 - 0.32 11.1 2.9 0.6 10.2 2.9 1.4 1 0 0 1 1 1 0 MASE2 domain Sugar_tr PF00083.24 EEA23274.1 - 2.3e-81 274.0 24.1 2.7e-81 273.7 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23274.1 - 2.2e-18 66.3 37.3 4.2e-16 58.8 28.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA23274.1 - 6.5 5.5 17.5 0.065 12.1 6.1 2.3 2 0 0 2 2 2 0 MFS_1 like family p450 PF00067.22 EEA23275.1 - 4e-78 263.2 0.0 5e-78 262.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2_2 PF12756.7 EEA23276.1 - 5.2e-07 29.9 0.5 0.00063 20.0 0.1 2.2 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EEA23276.1 - 0.00034 21.2 7.8 0.016 16.0 1.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA23276.1 - 0.0028 18.0 9.6 0.093 13.2 2.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type Prok-RING_4 PF14447.6 EEA23276.1 - 0.086 12.7 0.8 6.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EEA23276.1 - 0.14 12.2 2.0 8 6.6 0.1 2.5 2 0 0 2 2 2 0 RING-type zinc-finger zf-Di19 PF05605.12 EEA23276.1 - 0.62 10.4 6.2 1.1 9.6 0.6 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding MscL PF01741.18 EEA23277.1 - 8.7e-21 74.5 0.1 1.1e-20 74.2 0.1 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL C1_1 PF00130.22 EEA23277.1 - 0.034 14.0 2.5 0.065 13.1 2.5 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PyrI_C PF02748.15 EEA23277.1 - 0.14 12.0 0.5 0.14 12.0 0.5 1.9 2 1 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain CDC45 PF02724.14 EEA23278.1 - 3.4 5.8 20.0 5.5 5.1 20.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_76 PF03663.14 EEA23279.1 - 3.5e-43 148.5 18.4 4.2e-43 148.3 18.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EEA23279.1 - 5.6e-05 22.4 1.3 0.014 14.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 EEA23279.1 - 0.0041 15.7 0.0 0.28 9.6 0.0 2.2 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 Phage_holin_5_1 PF06946.11 EEA23279.1 - 0.13 12.7 2.0 9.8 6.6 0.0 3.0 2 1 1 3 3 3 0 Bacteriophage A118-like holin, Hol118 NAD_binding_1 PF00175.21 EEA23281.1 - 3.8e-29 101.5 0.0 6.5e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EEA23281.1 - 1.5e-17 63.7 0.0 2.6e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EEA23281.1 - 4.1e-06 27.0 0.0 0.00096 19.3 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Glyco_hydro_16 PF00722.21 EEA23282.1 - 1.3e-07 31.3 0.9 2.5e-07 30.4 0.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Acyl_transf_3 PF01757.22 EEA23282.1 - 3.8e-06 26.2 35.2 8e-06 25.1 35.2 1.4 1 0 0 1 1 1 1 Acyltransferase family Glyco_tranf_2_3 PF13641.6 EEA23283.1 - 3.9e-17 62.9 0.0 5.9e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EEA23283.1 - 5.7e-17 62.3 10.3 5.7e-17 62.3 10.3 1.9 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EEA23283.1 - 0.0014 18.2 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EEA23283.1 - 0.016 15.0 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 MSV199 PF10553.9 EEA23283.1 - 0.086 13.1 0.7 1.6 9.0 0.1 2.3 2 0 0 2 2 2 0 MSV199 domain Amino_oxidase PF01593.24 EEA23285.1 - 1.8e-06 27.5 0.1 1.8e-06 27.5 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase zf-MYND PF01753.18 EEA23286.1 - 6.4e-11 42.1 10.7 1.1e-10 41.4 10.7 1.4 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 EEA23286.1 - 0.085 12.7 9.2 0.14 12.0 9.2 1.4 1 0 0 1 1 1 0 HIT zinc finger zf-C6H2 PF15801.5 EEA23286.1 - 0.35 11.2 8.6 0.72 10.2 8.6 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Ecl1 PF12855.7 EEA23286.1 - 1.8 9.7 9.7 0.088 14.0 3.7 1.8 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins MFS_1 PF07690.16 EEA23287.1 - 3.4e-29 101.9 34.6 3.4e-29 101.9 34.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF21 PF01595.20 EEA23287.1 - 0.071 12.8 1.1 0.32 10.7 0.1 2.3 1 1 1 2 2 2 0 Cyclin M transmembrane N-terminal domain Peptidase_M20 PF01546.28 EEA23288.1 - 1.4e-07 31.4 0.0 2.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA23288.1 - 7.3e-06 25.9 0.0 2.1e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Fungal_trans_2 PF11951.8 EEA23290.1 - 2.1e-10 40.0 0.4 2.9e-06 26.3 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain CBM9_2 PF16011.5 EEA23291.1 - 0.0009 19.0 0.2 0.0014 18.4 0.2 1.3 1 1 0 1 1 1 1 Carbohydrate-binding family 9 Sugar_tr PF00083.24 EEA23292.1 - 1.6e-80 271.2 22.1 1.9e-80 271.0 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23292.1 - 9.8e-26 90.5 25.0 9.8e-26 90.5 25.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA23292.1 - 0.00025 19.6 2.6 0.00043 18.8 2.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Glyco_hydro_3_C PF01915.22 EEA23293.1 - 2.1e-56 191.1 0.0 5.3e-56 189.8 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA23293.1 - 5.8e-39 134.3 0.0 1e-38 133.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA23293.1 - 5.9e-24 84.0 0.0 1.2e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EEA23293.1 - 3.1e-14 53.0 0.0 6.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Zn_clus PF00172.18 EEA23294.1 - 2.6e-10 40.2 7.9 5.9e-10 39.1 7.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Caps_synth PF05704.12 EEA23295.1 - 6.1e-10 38.9 0.0 1e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 EEA23295.1 - 3.3e-05 24.4 0.0 6.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif WD40 PF00400.32 EEA23296.1 - 9.6e-117 377.5 59.1 5.3e-11 42.9 0.7 11.8 11 0 0 11 11 11 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA23296.1 - 1.8e-30 105.1 18.6 0.00035 20.8 0.0 11.3 2 1 9 11 11 11 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA23296.1 - 1.1e-23 83.7 33.1 0.021 13.8 0.1 11.1 1 1 10 11 11 11 10 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EEA23296.1 - 1.4e-16 60.9 5.5 0.0057 16.5 0.1 5.2 1 1 4 5 5 5 5 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EEA23296.1 - 2.2e-15 56.8 4.0 1.2e-05 24.8 0.1 5.9 1 1 5 6 6 6 3 WD40-like domain Cytochrom_D1 PF02239.16 EEA23296.1 - 2.7e-13 49.2 10.2 0.0026 16.4 0.2 5.3 1 1 4 6 6 6 5 Cytochrome D1 heme domain NACHT PF05729.12 EEA23296.1 - 1.9e-11 44.2 0.1 3.8e-11 43.2 0.1 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA23296.1 - 7e-09 36.3 0.2 2.1e-08 34.8 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain Ses_B PF17046.5 EEA23296.1 - 0.00034 20.5 2.7 0.0019 18.1 2.7 2.5 1 0 0 1 1 1 1 SesB domain on fungal death-pathway protein Methyltransf_3 PF01596.17 EEA23296.1 - 0.0005 19.3 0.0 36 3.5 0.0 5.9 3 1 3 7 7 7 0 O-methyltransferase AAA_22 PF13401.6 EEA23296.1 - 0.0011 19.2 0.0 0.0027 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain VID27 PF08553.10 EEA23296.1 - 0.0012 18.0 10.2 0.032 13.3 0.1 4.1 1 1 3 4 4 4 1 VID27 C-terminal WD40-like domain L_lac_phage_MSP PF06488.11 EEA23296.1 - 0.0019 17.6 8.8 0.36 10.1 0.1 4.9 1 1 4 6 6 6 2 Phage tail tube protein KAP_NTPase PF07693.14 EEA23296.1 - 0.003 16.8 0.0 0.0058 15.9 0.0 1.4 1 0 0 1 1 1 1 KAP family P-loop domain NB-ARC PF00931.22 EEA23296.1 - 0.011 14.9 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF5114 PF17141.4 EEA23296.1 - 0.018 15.6 17.7 5.1 7.7 0.2 6.4 1 1 6 8 8 8 0 Domain of unknown function (DUF5114) APS_kinase PF01583.20 EEA23296.1 - 0.024 14.6 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.29 EEA23296.1 - 0.032 14.7 0.2 0.14 12.6 0.1 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EEA23296.1 - 0.034 14.7 0.0 0.099 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain PD40 PF07676.12 EEA23296.1 - 0.058 13.4 28.2 57 3.8 0.1 10.9 12 0 0 12 12 12 0 WD40-like Beta Propeller Repeat Coat_X PF07552.11 EEA23296.1 - 0.063 13.1 15.9 4.2 7.3 0.1 6.8 7 2 2 9 9 8 0 Spore Coat Protein X and V domain AAA_30 PF13604.6 EEA23296.1 - 0.067 12.9 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Marek_SORF3 PF07153.11 EEA23296.1 - 0.14 11.5 9.3 14 4.9 0.1 5.2 2 1 3 6 6 6 0 Marek's disease-like virus SORF3 protein Aldedh PF00171.22 EEA23297.1 - 3.9e-132 441.1 0.1 4.7e-132 440.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA23297.1 - 0.03 13.8 0.1 0.11 12.0 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) p450 PF00067.22 EEA23298.1 - 3.3e-72 243.7 0.0 4.6e-72 243.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 EEA23299.1 - 4.5e-07 29.9 6.8 7.9e-07 29.1 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA23299.1 - 5.3e-06 25.7 0.0 1.2e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23300.1 - 5.5e-08 32.8 14.4 1.3e-07 31.6 14.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GEMIN8 PF15348.6 EEA23300.1 - 0.11 12.8 0.7 0.25 11.6 0.7 1.5 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 AF-4 PF05110.13 EEA23300.1 - 2.9 5.9 13.0 3.9 5.4 13.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 EEA23300.1 - 3.9 7.0 16.7 8 6.0 16.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Metallophos PF00149.28 EEA23301.1 - 1.5e-16 61.5 0.1 2.3e-16 60.9 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EEA23301.1 - 3.3e-14 53.5 0.0 1e-13 51.9 0.0 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EEA23301.1 - 9e-12 45.4 4.8 1.6e-11 44.6 4.8 1.4 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 EEA23301.1 - 0.00012 22.5 0.1 0.00025 21.5 0.1 1.5 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Cupin_2 PF07883.11 EEA23301.1 - 0.0035 17.0 0.0 0.0069 16.1 0.0 1.5 1 0 0 1 1 1 1 Cupin domain RRP7 PF12923.7 EEA23302.1 - 0.00018 21.6 0.2 0.0004 20.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Phosphoesterase PF04185.14 EEA23303.1 - 5.2e-71 239.7 5.5 9.5e-71 238.8 0.9 2.1 2 0 0 2 2 2 2 Phosphoesterase family RicinB_lectin_2 PF14200.6 EEA23303.1 - 0.00032 21.4 4.6 0.013 16.2 0.3 2.6 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Fascin PF06268.13 EEA23303.1 - 0.036 14.3 0.1 0.093 13.0 0.1 1.6 1 0 0 1 1 1 0 Fascin domain GATase PF00117.28 EEA23304.1 - 4.6e-36 124.4 0.0 2.5e-35 122.0 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 EEA23304.1 - 2e-34 117.5 0.0 3.8e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 EEA23304.1 - 2.6e-07 30.0 0.0 9.1e-05 21.7 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EEA23304.1 - 1.9e-05 24.6 0.0 3.9e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 PAPS_reduct PF01507.19 EEA23304.1 - 0.02 14.9 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family SIS PF01380.22 EEA23304.1 - 0.17 11.7 0.0 38 4.1 0.0 3.0 3 0 0 3 3 3 0 SIS domain tRNA_Me_trans PF03054.16 EEA23304.1 - 0.21 10.3 0.0 0.4 9.4 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase PNP_UDP_1 PF01048.20 EEA23305.1 - 2.2e-07 30.4 0.4 4.5e-07 29.4 0.4 1.5 1 1 0 1 1 1 1 Phosphorylase superfamily DHC_N1 PF08385.12 EEA23305.1 - 0.057 12.1 1.2 0.063 11.9 0.1 1.6 2 0 0 2 2 2 0 Dynein heavy chain, N-terminal region 1 FMN_dh PF01070.18 EEA23306.1 - 4.1e-95 318.8 0.0 5.7e-95 318.3 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EEA23306.1 - 5.6e-06 25.6 0.1 0.00018 20.6 0.0 2.2 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EEA23306.1 - 1.3e-05 24.5 0.0 2.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase Dimerisation PF08100.11 EEA23306.1 - 0.023 14.7 0.0 0.063 13.3 0.0 1.7 1 0 0 1 1 1 0 Dimerisation domain NMO PF03060.15 EEA23306.1 - 0.03 13.7 0.1 0.058 12.8 0.1 1.5 1 0 0 1 1 1 0 Nitronate monooxygenase ThiG PF05690.14 EEA23306.1 - 0.04 13.2 0.2 0.8 9.0 0.0 2.6 3 0 0 3 3 3 0 Thiazole biosynthesis protein ThiG Ank_2 PF12796.7 EEA23307.1 - 1.2e-45 153.9 0.0 3.1e-12 46.9 0.1 7.0 2 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA23307.1 - 3.1e-40 136.0 9.2 2.6e-08 34.2 0.0 10.0 6 4 4 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA23307.1 - 7.9e-34 115.3 8.0 1e-05 25.7 0.0 9.4 7 2 3 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA23307.1 - 1.2e-31 105.2 9.4 0.00059 20.1 0.0 12.9 13 1 0 13 13 13 6 Ankyrin repeat Ank PF00023.30 EEA23307.1 - 1.1e-28 98.4 16.0 0.00064 20.1 0.0 11.3 13 0 0 13 13 12 7 Ankyrin repeat SesA PF17107.5 EEA23307.1 - 5e-07 29.9 0.2 1.1e-05 25.5 0.0 2.7 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NACHT PF05729.12 EEA23307.1 - 7.5e-07 29.2 0.0 3.1e-06 27.2 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA23307.1 - 8.5e-06 26.3 0.0 4.5e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Helo_like_N PF17111.5 EEA23307.1 - 3.4e-05 23.3 0.1 0.00029 20.3 0.0 2.2 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins DUF2075 PF09848.9 EEA23307.1 - 0.00096 18.5 0.0 0.0027 17.0 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EEA23307.1 - 0.0062 16.8 0.0 0.021 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EEA23307.1 - 0.035 13.3 0.0 0.074 12.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Mg_chelatase PF01078.21 EEA23307.1 - 0.039 13.3 0.0 3.9 6.8 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI LANC_like PF05147.13 EEA23307.1 - 0.087 11.4 0.0 0.17 10.4 0.0 1.4 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein MFS_1 PF07690.16 EEA23308.1 - 1.1e-35 123.3 29.1 1.1e-35 123.3 29.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA23308.1 - 0.00029 20.2 1.7 0.00029 20.2 1.7 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Cad PF03596.13 EEA23309.1 - 2.9e-26 92.6 6.2 4.2e-26 92.1 6.2 1.1 1 0 0 1 1 1 1 Cadmium resistance transporter FAR1 PF03101.15 EEA23310.1 - 1.5e-08 35.3 0.1 2.7e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.11 EEA23310.1 - 0.00027 21.3 0.5 0.0098 16.3 0.5 2.6 1 1 0 1 1 1 1 Transcription factor AFT Trs65 PF12735.7 EEA23310.1 - 0.17 11.3 0.7 0.28 10.5 0.7 1.3 1 0 0 1 1 1 0 TRAPP trafficking subunit Trs65 COesterase PF00135.28 EEA23311.1 - 1.9e-91 307.5 0.2 6.6e-81 272.7 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA23311.1 - 7.7e-08 32.4 0.0 1.3e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Oxidored_FMN PF00724.20 EEA23313.1 - 2.1e-59 201.5 0.0 9.4e-56 189.5 0.0 2.2 1 1 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Sugar_tr PF00083.24 EEA23314.1 - 4.4e-97 325.8 26.6 5.4e-97 325.5 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23314.1 - 3.7e-37 128.1 50.8 2.4e-31 109.0 23.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA23314.1 - 0.75 8.3 26.5 0.017 13.7 8.1 3.3 2 1 1 3 3 3 0 MFS/sugar transport protein FAA_hydrolase PF01557.18 EEA23315.1 - 3.1e-48 164.3 0.0 4.3e-48 163.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EEA23315.1 - 1.4e-23 83.1 0.0 2.2e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Lactamase_B PF00753.27 EEA23316.1 - 8e-06 26.0 2.1 1.6e-05 25.0 2.1 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA23316.1 - 0.0025 17.4 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain MFS_1 PF07690.16 EEA23318.1 - 7.1e-08 31.8 38.0 1.2e-06 27.7 0.1 4.5 4 2 0 4 4 4 2 Major Facilitator Superfamily LapA_dom PF06305.11 EEA23318.1 - 1 9.3 8.4 9.1 6.2 0.0 4.4 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain adh_short PF00106.25 EEA23320.1 - 8.9e-19 67.7 0.0 1.9e-18 66.6 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23320.1 - 1.9e-14 53.8 0.0 5.5e-14 52.3 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 EEA23320.1 - 0.034 14.1 0.1 0.045 13.6 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ank_2 PF12796.7 EEA23321.1 - 5.9e-90 296.0 0.0 1.2e-13 51.4 0.0 7.7 1 1 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA23321.1 - 4.8e-57 183.2 0.2 0.0012 19.2 0.0 16.0 15 1 1 16 16 16 12 Ankyrin repeat Ank_4 PF13637.6 EEA23321.1 - 1.3e-54 181.9 0.1 3.1e-08 34.0 0.0 9.9 5 2 5 10 10 10 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA23321.1 - 6.9e-53 176.0 4.5 1.4e-05 25.2 0.0 12.0 3 2 9 12 12 12 11 Ankyrin repeats (many copies) Ank PF00023.30 EEA23321.1 - 3.3e-47 156.9 4.5 0.0019 18.5 0.0 16.2 15 1 0 15 15 15 11 Ankyrin repeat CorA PF01544.18 EEA23321.1 - 1.5e-07 31.0 0.2 2.8e-07 30.1 0.2 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Fungal_trans PF04082.18 EEA23322.1 - 6.3e-18 64.7 0.1 1.1e-17 64.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23322.1 - 7.9e-09 35.5 5.0 1.7e-08 34.5 5.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EEA23323.1 - 6.2e-24 84.5 0.0 5.9e-21 74.8 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23323.1 - 6.5e-14 52.1 0.0 1.9e-12 47.3 0.1 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23323.1 - 5.2e-10 39.5 0.1 7.5e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Aminotran_1_2 PF00155.21 EEA23324.1 - 5.7e-12 45.5 0.0 2.2e-11 43.6 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EEA23324.1 - 0.0057 15.5 0.0 0.049 12.4 0.0 2.0 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase Cas_St_Csn2 PF16813.5 EEA23324.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Csn2 subfamily St PhyH PF05721.13 EEA23325.1 - 7.9e-20 72.0 0.0 9.4e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EEA23325.1 - 0.015 14.1 0.0 0.035 12.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) Cytochrom_D1 PF02239.16 EEA23325.1 - 0.024 13.2 0.0 0.036 12.6 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain PhyH PF05721.13 EEA23326.1 - 7.9e-20 72.0 0.0 9.4e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EEA23326.1 - 0.015 14.1 0.0 0.035 12.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) Cytochrom_D1 PF02239.16 EEA23326.1 - 0.024 13.2 0.0 0.036 12.6 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain AA_permease PF00324.21 EEA23327.1 - 6e-112 374.7 39.7 7.4e-112 374.4 39.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA23327.1 - 2.1e-24 86.1 45.5 2.5e-24 85.9 45.5 1.0 1 0 0 1 1 1 1 Amino acid permease Fungal_trans_2 PF11951.8 EEA23328.1 - 1.1e-45 156.1 2.1 1.3e-45 155.9 2.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4404 PF14357.6 EEA23328.1 - 0.15 12.7 0.9 20 5.9 0.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Abhydrolase_6 PF12697.7 EEA23329.1 - 4.1e-13 50.4 0.0 7.8e-13 49.5 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 EEA23329.1 - 0.09 12.3 0.1 0.49 9.9 0.0 2.2 2 1 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) TMEM252 PF15664.5 EEA23330.1 - 0.34 10.6 4.4 0.58 9.9 4.4 1.3 1 0 0 1 1 1 0 Transmembrane protein 252 family RCR PF12273.8 EEA23330.1 - 0.7 10.6 7.1 1.3 9.7 7.1 1.4 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red OPT PF03169.15 EEA23332.1 - 1.6e-126 423.4 43.5 1.9e-126 423.2 43.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein AMP-binding PF00501.28 EEA23333.1 - 8.3e-102 340.9 0.0 9.8e-102 340.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA23333.1 - 5.6e-12 46.5 0.0 1.5e-11 45.1 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain K_oxygenase PF13434.6 EEA23334.1 - 4.8e-117 390.9 0.1 5.6e-117 390.7 0.1 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EEA23334.1 - 6.3e-12 45.4 0.1 6.9e-10 38.7 0.0 3.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA23334.1 - 3.5e-10 39.6 0.0 6e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA23334.1 - 3.6e-07 30.3 0.0 0.00052 20.0 0.0 3.2 2 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EEA23334.1 - 0.0054 17.3 0.0 0.58 10.7 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DUF3632 PF12311.8 EEA23335.1 - 1.5e-15 58.0 0.0 2.1e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) DUF3632 PF12311.8 EEA23336.1 - 1.8e-09 38.3 0.0 2.5e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) DUF3632 PF12311.8 EEA23337.1 - 1.2e-09 38.9 0.0 1.5e-09 38.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) p450 PF00067.22 EEA23338.1 - 1.2e-64 218.8 0.0 1.4e-64 218.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pyr_redox_2 PF07992.14 EEA23339.1 - 1.1e-20 74.1 0.0 1.3e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA23339.1 - 5.6e-11 42.9 0.3 1.1e-10 42.0 0.3 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA23339.1 - 3.8e-06 26.2 0.5 0.01 14.9 0.1 2.3 1 1 1 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EEA23339.1 - 0.00022 20.6 0.0 0.00035 19.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA23339.1 - 0.0022 17.2 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EEA23339.1 - 0.076 12.2 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 EEA23339.1 - 0.12 12.6 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA23339.1 - 0.12 11.9 2.1 0.14 11.7 0.3 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase ApbA PF02558.16 EEA23339.1 - 0.13 11.9 0.1 0.56 9.9 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 EEA23339.1 - 0.43 9.4 1.3 7.2 5.3 0.2 2.1 2 0 0 2 2 2 0 Tryptophan halogenase gag_pre-integrs PF13976.6 EEA23340.1 - 9.8e-08 31.8 0.0 1.9e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA23340.1 - 0.00024 21.3 0.0 0.00046 20.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF4508 PF14969.6 EEA23340.1 - 0.022 15.0 0.3 0.13 12.6 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4508) REV1_C PF16727.5 EEA23340.1 - 0.14 12.6 2.7 6.6 7.2 0.3 2.6 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain RVT_2 PF07727.14 EEA23341.1 - 5e-27 95.1 0.2 9.7e-27 94.2 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EEA23341.1 - 0.0007 19.2 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA23341.1 - 0.035 14.0 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK HAD_2 PF13419.6 EEA23342.1 - 1.7e-10 41.3 0.0 2e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA23342.1 - 2.7e-05 24.6 0.0 3.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA23342.1 - 0.00037 20.5 0.0 0.00071 19.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like TPT PF03151.16 EEA23343.1 - 2.1e-27 96.3 29.0 3.2e-27 95.6 28.3 1.6 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.11 EEA23343.1 - 0.0012 18.2 25.4 0.0017 17.6 25.4 1.2 1 0 0 1 1 1 1 UAA transporter family Dioxygenase_C PF00775.21 EEA23344.1 - 2.9e-37 127.9 0.0 4e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EEA23344.1 - 6.2e-28 96.5 0.0 1.1e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 Catechol dioxygenase N terminus NOA36 PF06524.12 EEA23345.1 - 9.2 5.5 20.9 12 5.1 20.9 1.2 1 0 0 1 1 1 0 NOA36 protein ADP_ribosyl_GH PF03747.14 EEA23346.1 - 5.5e-62 210.1 0.4 6.5e-62 209.9 0.4 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase PhyH PF05721.13 EEA23347.1 - 5e-15 56.3 0.1 8.1e-15 55.6 0.1 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EEA23347.1 - 0.0011 17.8 0.0 0.002 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) pPIWI_RE_Z PF18155.1 EEA23347.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 pPIWI RE three-gene island domain Z Fungal_trans_2 PF11951.8 EEA23348.1 - 7.7e-49 166.5 0.6 9.8e-49 166.2 0.6 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23348.1 - 1.1e-08 35.0 12.5 1.9e-08 34.2 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldolase_II PF00596.21 EEA23349.1 - 3.5e-46 157.5 0.0 4.4e-46 157.1 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain AA_permease PF00324.21 EEA23350.1 - 4.4e-67 226.7 41.5 5.3e-67 226.5 41.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA23350.1 - 3.5e-23 82.1 48.0 4.3e-23 81.8 48.0 1.1 1 0 0 1 1 1 1 Amino acid permease ApbA PF02558.16 EEA23351.1 - 6.8e-30 103.7 0.1 1e-29 103.1 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EEA23351.1 - 4.2e-26 91.6 0.0 2.6e-25 89.0 0.0 2.3 4 0 0 4 4 4 1 Ketopantoate reductase PanE/ApbA C terminal ThiF PF00899.21 EEA23351.1 - 0.026 13.9 0.7 0.057 12.8 0.7 1.5 1 0 0 1 1 1 0 ThiF family NmrA PF05368.13 EEA23352.1 - 3.2e-12 46.5 0.0 5.5e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA23352.1 - 1.6e-11 44.4 0.1 2.4e-11 43.9 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA23352.1 - 0.0015 18.1 0.1 0.0023 17.4 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EEA23352.1 - 0.002 18.6 0.0 0.0036 17.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EEA23352.1 - 0.0054 16.9 0.1 0.012 15.7 0.0 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 EEA23352.1 - 0.092 11.8 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain SepF PF04472.12 EEA23352.1 - 0.094 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Cell division protein SepF NAD_binding_10 PF13460.6 EEA23353.1 - 2.1e-10 40.8 0.1 2.6e-10 40.5 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding DUF3175 PF11373.8 EEA23353.1 - 0.025 14.7 0.0 0.04 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3175) AflR PF08493.10 EEA23354.1 - 2e-10 40.6 4.1 2e-10 40.6 4.1 1.8 2 1 0 2 2 2 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EEA23354.1 - 6.5e-10 39.0 10.2 1.2e-09 38.2 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BNR_2 PF13088.6 EEA23355.1 - 2.1e-19 69.9 0.1 5.3e-11 42.3 0.2 2.0 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.20 EEA23355.1 - 4.7e-05 22.8 22.3 0.46 10.7 1.3 6.2 5 0 0 5 5 5 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 EEA23355.1 - 0.00068 18.5 1.1 0.0074 15.1 0.0 2.5 1 1 1 2 2 2 1 Sortilin, neurotensin receptor 3, BNR_4 PF15892.5 EEA23355.1 - 0.0047 16.3 0.4 0.04 13.3 0.0 1.9 1 1 1 2 2 2 2 BNR repeat-containing family member F5_F8_type_C PF00754.25 EEA23355.1 - 0.1 12.7 6.2 13 6.0 0.0 4.2 1 1 2 5 5 5 0 F5/8 type C domain CyRPA PF18638.1 EEA23355.1 - 0.56 9.3 2.8 10 5.2 0.0 3.3 3 1 1 4 4 4 0 Cysteine-Rich Protective Antigen 6 bladed domain Response_reg PF00072.24 EEA23356.1 - 3.8e-21 75.3 0.1 1e-20 74.0 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EEA23356.1 - 8e-20 71.4 0.0 1.9e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EEA23356.1 - 1.5e-12 47.4 1.2 3.4e-12 46.2 0.2 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 EEA23356.1 - 0.035 14.7 0.0 0.1 13.2 0.0 1.9 1 0 0 1 1 1 0 GAF domain GAF_2 PF13185.6 EEA23356.1 - 0.043 14.1 0.0 0.13 12.6 0.0 1.8 2 0 0 2 2 2 0 GAF domain GAF_3 PF13492.6 EEA23356.1 - 0.11 12.9 0.0 0.42 11.0 0.0 2.1 2 0 0 2 2 2 0 GAF domain Pyr_redox_2 PF07992.14 EEA23357.1 - 5.9e-17 61.8 0.0 1.1e-15 57.7 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA23357.1 - 1.7e-06 27.4 0.2 0.00018 20.8 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 EEA23357.1 - 7.5e-06 25.4 0.7 0.17 11.1 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA23357.1 - 8.7e-06 25.8 0.2 0.093 12.7 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.14 EEA23357.1 - 8.1e-05 21.5 0.1 0.039 12.7 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein DAO PF01266.24 EEA23357.1 - 0.0023 17.6 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA23357.1 - 0.0035 16.6 0.0 0.0074 15.5 0.0 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EEA23357.1 - 0.0048 16.2 0.1 0.0089 15.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA23357.1 - 0.0069 16.6 0.1 0.02 15.1 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EEA23357.1 - 0.01 14.9 0.1 0.02 14.0 0.1 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.6 EEA23357.1 - 0.041 13.0 0.0 2.1 7.4 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) RVT_2 PF07727.14 EEA23358.1 - 9.4e-11 41.8 0.0 1.6e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA23358.1 - 1.5e-07 31.6 0.3 5.7e-06 26.5 0.0 3.0 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 EEA23358.1 - 0.00023 21.0 0.2 0.00075 19.3 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA23358.1 - 0.14 12.4 0.0 0.75 10.0 0.0 2.3 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Integrase_H2C2 PF17921.1 EEA23358.1 - 0.85 9.8 8.7 0.47 10.6 0.1 3.6 3 0 0 3 3 3 0 Integrase zinc binding domain Abhydrolase_1 PF00561.20 EEA23360.1 - 6.7e-20 71.8 0.2 5e-19 69.0 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA23360.1 - 2.1e-19 71.0 2.1 4.4e-19 70.0 2.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA23360.1 - 4.5e-08 32.7 0.0 1e-07 31.5 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ndr PF03096.14 EEA23360.1 - 0.0014 17.4 0.0 0.0022 16.8 0.0 1.2 1 0 0 1 1 1 1 Ndr family Chlorophyllase2 PF12740.7 EEA23360.1 - 0.047 12.6 0.0 0.1 11.5 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF659 PF04937.15 EEA23362.1 - 1.7e-10 40.9 1.0 3.1e-10 40.1 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Dimer_Tnp_hAT PF05699.14 EEA23362.1 - 2.8e-06 27.0 0.1 8.9e-06 25.4 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2110 PF09883.9 EEA23362.1 - 0.055 13.1 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) APG6_N PF17675.1 EEA23362.1 - 0.25 11.9 6.9 0.75 10.3 6.9 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region MFS_1 PF07690.16 EEA23363.1 - 1e-33 116.8 24.6 1e-33 116.8 24.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4519 PF15012.6 EEA23363.1 - 0.068 13.4 0.2 0.24 11.6 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) TPT PF03151.16 EEA23364.1 - 6.7e-21 74.9 22.6 8.5e-21 74.6 22.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EEA23364.1 - 2.7e-08 33.4 23.3 1.3e-07 31.2 23.2 1.9 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EEA23364.1 - 0.00071 19.8 14.2 0.00071 19.8 14.2 3.1 3 1 0 3 3 3 2 EamA-like transporter family Peptidase_C12 PF01088.21 EEA23365.1 - 1.2e-40 139.5 0.0 1.4e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Nucleotid_trans PF03407.16 EEA23366.1 - 4.3e-10 39.9 0.7 6.8e-10 39.3 0.7 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_transf_34 PF05637.12 EEA23366.1 - 7.9e-09 35.6 5.8 6.6e-08 32.6 5.7 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 EEA23367.1 - 4e-10 40.0 0.7 6.4e-10 39.4 0.7 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_transf_34 PF05637.12 EEA23367.1 - 6.9e-09 35.8 5.7 5.7e-08 32.8 5.5 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Glyco_hydro_31 PF01055.26 EEA23368.1 - 7.8e-144 480.1 5.3 1e-143 479.7 5.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EEA23368.1 - 4.5e-35 120.3 0.0 8e-35 119.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EEA23368.1 - 1.7e-07 31.4 0.3 4e-07 30.3 0.3 1.7 1 0 0 1 1 1 1 Galactose mutarotase-like DsbD PF02683.15 EEA23369.1 - 0.04 13.8 1.0 0.089 12.7 1.0 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region Amidohydro_1 PF01979.20 EEA23370.1 - 8e-27 94.5 0.0 8.1e-26 91.1 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA23370.1 - 2e-15 57.3 0.1 2.8e-06 27.1 0.0 2.6 2 1 0 3 3 3 2 Amidohydrolase family Urease_alpha PF00449.20 EEA23370.1 - 0.0034 17.7 0.1 0.0072 16.7 0.1 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain DHDPS PF00701.22 EEA23371.1 - 1.3e-35 122.5 0.0 5.5e-35 120.5 0.0 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family Fungal_trans PF04082.18 EEA23372.1 - 2.4e-22 79.3 3.2 3.4e-22 78.7 3.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23372.1 - 8.7e-08 32.2 10.7 1.4e-07 31.5 10.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TauD PF02668.16 EEA23373.1 - 1.2e-50 172.8 0.1 1.5e-50 172.5 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EEA23374.1 - 3.5e-34 118.3 29.5 3.5e-34 118.3 29.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4901 PF16244.5 EEA23374.1 - 0.061 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4901) FliC PF12445.8 EEA23374.1 - 0.12 12.7 0.1 0.24 11.7 0.1 1.4 1 0 0 1 1 1 0 Flagellin protein DHHC PF01529.20 EEA23374.1 - 1.5 8.9 4.5 2.1 8.5 0.1 2.9 2 2 0 2 2 2 0 DHHC palmitoyltransferase MFS_1 PF07690.16 EEA23375.1 - 8.3e-33 113.8 24.1 1.1e-32 113.3 24.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sulfatase PF00884.23 EEA23376.1 - 5.7e-67 226.3 0.5 8e-67 225.8 0.5 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EEA23376.1 - 0.032 13.8 0.1 4.8 6.7 0.0 2.1 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EEA23376.1 - 0.042 12.5 0.1 0.19 10.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF229) MFS_1 PF07690.16 EEA23377.1 - 3e-39 135.0 46.9 3e-39 135.0 46.9 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA23377.1 - 1.1e-11 43.9 10.8 1.1e-11 43.9 10.8 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EEA23377.1 - 2.6e-06 26.1 0.9 5.1e-06 25.2 0.9 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector Antimicrobial10 PF08105.11 EEA23377.1 - 0.063 13.4 0.0 0.3 11.2 0.0 2.2 1 0 0 1 1 1 0 Metchnikowin family FA_desaturase PF00487.24 EEA23377.1 - 0.86 9.4 13.2 0.044 13.6 3.9 2.3 2 0 0 2 2 2 0 Fatty acid desaturase DUF1793 PF08760.11 EEA23378.1 - 2.4e-39 135.5 1.6 2.8e-39 135.2 1.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 EEA23379.1 - 4.1e-54 182.8 0.5 3.7e-51 173.2 0.5 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EEA23379.1 - 1.1e-14 54.8 1.1 1.4e-07 31.6 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF5127) DUF1793 PF08760.11 EEA23379.1 - 7.5e-09 36.3 0.1 1.7e-08 35.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) Alginate_lyase PF05426.12 EEA23379.1 - 0.025 14.2 0.2 0.038 13.5 0.2 1.3 1 0 0 1 1 1 0 Alginate lyase Bac_rhamnosid6H PF17389.2 EEA23379.1 - 0.036 13.3 0.9 0.083 12.1 0.9 1.5 1 1 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain ArabFuran-catal PF09206.11 EEA23380.1 - 3e-147 490.0 9.7 3.9e-147 489.6 9.7 1.1 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 EEA23380.1 - 9.9e-58 194.1 1.6 1.9e-57 193.2 1.4 1.6 1 1 1 2 2 2 1 Alpha-L-arabinofuranosidase B (ABFB) domain MFS_1 PF07690.16 EEA23381.1 - 2.4e-16 59.6 48.6 1.9e-15 56.7 26.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2614 PF11023.8 EEA23381.1 - 5.5 7.1 10.3 0.48 10.5 0.3 3.4 2 2 2 4 4 4 0 Zinc-ribbon containing domain CaATP_NAI PF12515.8 EEA23383.1 - 0.27 10.9 0.4 1.3 8.7 0.4 1.9 1 1 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Pro-kuma_activ PF09286.11 EEA23384.1 - 4.2e-44 150.3 0.0 1.1e-43 149.0 0.0 1.7 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Na_H_Exchanger PF00999.21 EEA23385.1 - 2.7e-58 197.6 48.9 4.2e-58 197.0 48.9 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family rve PF00665.26 EEA23387.1 - 1.1e-07 32.0 0.1 2.9e-07 30.7 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EEA23387.1 - 0.00021 21.1 0.8 0.00021 21.1 0.8 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain RVT_2 PF07727.14 EEA23387.1 - 0.21 11.2 0.1 0.33 10.6 0.1 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EEA23390.1 - 1.1e-22 80.7 0.0 2.9e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 EEA23390.1 - 0.0014 18.7 1.6 0.0014 18.7 1.6 2.2 2 0 0 2 2 2 1 Zinc knuckle DUF3071 PF11268.8 EEA23390.1 - 0.011 15.8 0.1 0.053 13.6 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) zf-RVT PF13966.6 EEA23390.1 - 0.05 14.3 0.1 0.05 14.3 0.1 2.7 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase DUF16 PF01519.16 EEA23390.1 - 3.7 8.1 11.2 0.16 12.4 4.3 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 EEA23390.1 - 8.3 7.1 12.1 0.29 11.8 2.0 3.4 2 1 0 2 2 2 0 SlyX BORCS7 PF16088.5 EEA23390.1 - 9.4 6.6 8.4 0.78 10.0 2.5 2.3 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 Alpha_GJ PF03229.13 EEA23391.1 - 0.0061 17.1 1.0 0.01 16.4 1.0 1.3 1 0 0 1 1 1 1 Alphavirus glycoprotein J Ank_2 PF12796.7 EEA23392.1 - 1.2e-69 230.9 15.4 2.9e-13 50.2 0.3 9.7 5 2 6 11 11 11 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA23392.1 - 2e-69 229.1 8.2 2.2e-08 34.4 0.0 12.6 7 2 5 14 14 14 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA23392.1 - 2.4e-51 165.7 27.8 0.0021 18.4 0.0 18.7 20 0 0 20 20 20 13 Ankyrin repeat Ank PF00023.30 EEA23392.1 - 4e-34 115.6 36.8 0.011 16.1 0.2 16.9 19 0 0 19 19 19 10 Ankyrin repeat Ank_5 PF13857.6 EEA23392.1 - 1.2e-26 92.3 25.1 0.099 13.0 0.1 14.8 6 4 10 16 16 16 11 Ankyrin repeats (many copies) SnoaL_2 PF12680.7 EEA23392.1 - 0.12 13.1 0.0 38 5.0 0.0 2.8 2 0 0 2 2 2 0 SnoaL-like domain NmrA PF05368.13 EEA23393.1 - 1.4e-12 47.7 0.0 1.9e-11 44.0 0.0 2.1 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA23393.1 - 1.7e-08 34.6 0.0 2.8e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Glyco_hydro_17 PF00332.18 EEA23395.1 - 0.0034 17.0 0.8 0.019 14.6 0.4 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 p450 PF00067.22 EEA23396.1 - 9e-53 179.6 0.0 1.1e-52 179.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EEA23397.1 - 1.1e-45 156.1 60.2 9e-45 153.1 59.4 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA23397.1 - 3.7e-19 68.6 24.9 5e-19 68.2 24.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA23397.1 - 3.2e-17 62.5 5.3 3.2e-17 62.5 5.3 3.3 2 1 1 3 3 3 1 Sugar (and other) transporter Fungal_trans_2 PF11951.8 EEA23398.1 - 2.5e-07 29.9 0.7 8e-05 21.6 0.7 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF1186 PF06685.11 EEA23398.1 - 0.0083 15.5 0.0 0.17 11.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1186) ADH_zinc_N PF00107.26 EEA23399.1 - 1.6e-23 83.1 0.2 2.7e-23 82.4 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA23399.1 - 1.4e-15 58.5 0.1 4.5e-15 56.9 0.1 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA23399.1 - 5.8e-08 32.6 0.0 1.3e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain WD40 PF00400.32 EEA23400.1 - 0.00028 21.6 0.4 0.0036 18.1 0.1 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF5329 PF17263.2 EEA23400.1 - 0.093 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5329) Zn_clus PF00172.18 EEA23401.1 - 1.1e-08 35.0 7.5 2.1e-08 34.2 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Epimerase PF01370.21 EEA23402.1 - 8.4e-13 48.3 0.1 2.2e-12 46.9 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EEA23402.1 - 2.7e-10 40.2 0.1 6.6e-10 38.9 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EEA23402.1 - 5.2e-10 39.5 0.1 1e-09 38.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EEA23402.1 - 1.1e-06 28.3 0.2 9e-06 25.3 0.1 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EEA23402.1 - 0.00024 20.6 0.1 0.0007 19.1 0.1 1.8 2 0 0 2 2 2 1 short chain dehydrogenase Semialdhyde_dh PF01118.24 EEA23402.1 - 0.0015 18.9 0.6 0.28 11.6 0.2 2.6 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EEA23402.1 - 0.0018 17.4 0.0 0.031 13.4 0.0 2.0 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EEA23402.1 - 0.0031 16.7 0.0 0.0051 16.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EEA23402.1 - 0.0032 16.5 0.0 0.0046 16.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 EEA23402.1 - 0.0087 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 KR domain UDPG_MGDP_dh_N PF03721.14 EEA23402.1 - 0.042 13.4 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EEA23402.1 - 0.06 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 EEA23402.1 - 0.088 11.9 0.1 0.32 10.1 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DapB_N PF01113.20 EEA23402.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Glyco_hydro_43 PF04616.14 EEA23403.1 - 2.5e-107 358.5 2.2 4.2e-105 351.2 0.8 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EEA23403.1 - 9.7e-50 169.1 0.0 1.4e-49 168.6 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1349 PF07081.11 EEA23403.1 - 0.007 16.1 0.3 0.015 15.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1349) Lipase_GDSL_2 PF13472.6 EEA23404.1 - 9.6e-14 52.2 0.2 1.4e-13 51.7 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EEA23404.1 - 0.0035 17.3 0.0 0.0064 16.5 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Glyco_hydro_67M PF07488.12 EEA23405.1 - 1.1e-137 458.5 0.0 1.5e-137 458.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 EEA23405.1 - 1.6e-87 292.7 2.3 1.7e-87 292.7 1.3 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.14 EEA23405.1 - 5.2e-23 81.6 0.0 8.6e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.15 EEA23405.1 - 0.011 16.5 0.0 0.022 15.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 Sugar_tr PF00083.24 EEA23406.1 - 2.8e-82 277.0 22.1 3.2e-82 276.8 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23406.1 - 4.1e-12 45.7 37.0 8.2e-08 31.6 25.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Tannase PF07519.11 EEA23407.1 - 1.6e-120 403.2 2.6 1.9e-120 402.9 2.6 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 EEA23407.1 - 0.0083 15.8 1.4 0.051 13.2 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA23407.1 - 0.031 13.5 0.0 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_M61 PF05299.12 EEA23408.1 - 0.00023 21.5 0.4 0.0012 19.2 0.4 2.0 1 1 0 1 1 1 1 M61 glycyl aminopeptidase Peptidase_M1 PF01433.20 EEA23408.1 - 0.018 14.6 0.1 0.039 13.5 0.0 1.5 2 0 0 2 2 2 0 Peptidase family M1 domain Peptidase_M99_m PF17130.4 EEA23408.1 - 0.041 13.8 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 beta-barrel domain of carboxypeptidase M99 APH PF01636.23 EEA23409.1 - 1.2e-10 41.8 0.0 3.1e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EEA23409.1 - 0.25 10.2 0.0 2.2 7.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Chitin_synth_2 PF03142.15 EEA23411.1 - 1.2e-291 967.9 0.1 1.6e-291 967.5 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EEA23411.1 - 4.2e-13 49.7 3.4 1.6e-12 47.8 3.4 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EEA23411.1 - 1.6e-10 41.3 0.0 3.2e-09 37.0 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EEA23411.1 - 0.0001 22.1 0.0 0.0093 15.8 0.0 2.7 3 0 0 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EEA23411.1 - 0.00032 20.2 0.0 0.0042 16.6 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 AveC_like PF17198.4 EEA23411.1 - 0.0026 17.2 0.1 0.0026 17.2 0.1 2.3 2 0 0 2 2 2 1 Spirocyclase AveC-like Sel1 PF08238.12 EEA23412.1 - 7.2e-33 112.3 24.2 3.7e-05 24.3 1.5 7.5 7 0 0 7 7 7 7 Sel1 repeat 2-Hacid_dh_C PF02826.19 EEA23413.1 - 4.9e-37 127.0 0.0 2.1e-20 72.9 0.0 3.2 3 0 0 3 3 3 3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 EEA23413.1 - 0.021 13.6 0.0 0.03 13.0 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase DUF1965 PF09248.10 EEA23413.1 - 0.045 13.5 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) F420_oxidored PF03807.17 EEA23413.1 - 0.13 12.9 0.1 0.38 11.4 0.0 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF2642 PF10842.8 EEA23413.1 - 0.16 11.8 0.0 0.55 10.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) 3HCDH_N PF02737.18 EEA23413.1 - 0.18 11.6 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cation_efflux PF01545.21 EEA23414.1 - 1.6e-52 178.2 9.8 6.1e-52 176.2 9.8 1.8 1 1 0 1 1 1 1 Cation efflux family Dicty_CAR PF05462.11 EEA23414.1 - 0.052 12.7 0.5 0.089 11.9 0.5 1.3 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor DUF3613 PF12266.8 EEA23415.1 - 0.013 15.3 0.1 0.03 14.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3613) Myosin_head PF00063.21 EEA23416.1 - 1.5e-240 800.1 5.7 1.8e-240 799.8 5.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EEA23416.1 - 2.1e-51 174.3 0.0 4e-51 173.4 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EEA23416.1 - 3.8e-13 48.8 0.0 1e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EEA23416.1 - 4.3e-08 32.7 0.0 1.7e-07 30.8 0.0 2.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EEA23416.1 - 1.1e-06 28.3 0.0 3.4e-06 26.8 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain Hpr_kinase_C PF07475.12 EEA23416.1 - 0.0095 15.5 2.4 2.6 7.5 0.0 3.6 4 0 0 4 4 4 1 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 EEA23416.1 - 0.016 15.5 0.0 0.056 13.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain IQ PF00612.27 EEA23416.1 - 0.031 14.1 9.7 1.1 9.3 1.0 2.6 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_16 PF13191.6 EEA23416.1 - 0.034 14.5 0.0 0.088 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain DUF2075 PF09848.9 EEA23416.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EEA23416.1 - 0.19 11.7 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 NACHT domain OPA3 PF07047.12 EEA23418.1 - 3.7e-48 162.4 4.1 5.5e-48 161.9 4.1 1.3 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Med11 PF10280.9 EEA23418.1 - 0.006 17.0 1.3 0.006 17.0 1.3 1.8 2 0 0 2 2 2 1 Mediator complex protein BatD PF13584.6 EEA23418.1 - 0.0069 15.3 0.8 0.0096 14.8 0.8 1.2 1 0 0 1 1 1 1 Oxygen tolerance Mito_fiss_reg PF05308.11 EEA23418.1 - 1 9.4 9.7 0.13 12.3 1.9 2.1 2 0 0 2 2 2 0 Mitochondrial fission regulator APG6_N PF17675.1 EEA23418.1 - 1.6 9.3 12.4 0.76 10.3 2.4 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Pkinase PF00069.25 EEA23419.1 - 4.2e-68 229.6 0.0 6.1e-68 229.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23419.1 - 7.5e-44 150.0 0.0 1.2e-43 149.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EEA23419.1 - 7.8e-08 32.4 0.0 0.017 15.3 0.0 3.1 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EEA23419.1 - 7.7e-06 25.4 0.0 1.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA23419.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF202 PF02656.15 EEA23420.1 - 2.2e-14 53.6 1.6 2.2e-14 53.6 1.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Ndc1_Nup PF09531.10 EEA23420.1 - 0.041 12.6 0.7 0.046 12.4 0.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mt_ATP-synt_B PF05405.14 EEA23420.1 - 0.33 10.6 2.0 0.49 10.0 2.0 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Peptidase_S64 PF08192.11 EEA23420.1 - 0.87 8.0 6.8 1 7.7 6.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.9 EEA23420.1 - 2 7.2 7.6 2.4 6.9 7.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain LAMTOR PF15454.6 EEA23420.1 - 2.8 8.6 10.1 0.36 11.5 5.4 1.8 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator HATPase_c_3 PF13589.6 EEA23421.1 - 6.5e-14 51.9 0.1 1.5e-13 50.8 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 EEA23421.1 - 9.1e-12 44.7 0.0 2.5e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 EEA23421.1 - 7.1e-08 32.9 0.0 1.7e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DHHC PF01529.20 EEA23422.1 - 8e-32 110.2 6.5 1.4e-31 109.3 6.5 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase Cupin_1 PF00190.22 EEA23423.1 - 3.4e-39 133.9 0.0 3.1e-20 72.3 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EEA23423.1 - 8.2e-22 76.7 0.1 2.7e-12 46.2 0.0 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EEA23423.1 - 6.1e-08 32.2 0.0 0.0078 15.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 EEA23423.1 - 5e-05 23.2 0.1 0.0014 18.6 0.0 2.3 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_6 PF12852.7 EEA23423.1 - 0.001 18.8 0.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 2 Cupin MannoseP_isomer PF01050.18 EEA23423.1 - 0.002 18.0 0.0 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase Cupin_4 PF08007.12 EEA23423.1 - 0.14 11.6 0.0 1.6 8.1 0.0 2.1 2 0 0 2 2 2 0 Cupin superfamily protein 3-HAO PF06052.12 EEA23423.1 - 0.17 11.6 0.0 0.37 10.4 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Apolipoprotein PF01442.18 EEA23425.1 - 0.0013 18.7 3.9 0.0026 17.7 3.9 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Helo_like_N PF17111.5 EEA23425.1 - 0.0036 16.7 3.0 0.0089 15.4 3.0 1.6 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins FlaC_arch PF05377.11 EEA23425.1 - 0.083 13.3 2.7 0.43 11.0 1.3 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Lzipper-MIP1 PF14389.6 EEA23425.1 - 0.19 12.1 12.6 0.33 11.3 1.6 3.7 4 0 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Snapin_Pallidin PF14712.6 EEA23425.1 - 0.38 11.2 7.7 0.13 12.6 2.3 2.6 1 1 1 2 2 2 0 Snapin/Pallidin Macoilin PF09726.9 EEA23425.1 - 0.59 8.6 26.0 0.0027 16.3 16.6 1.7 2 0 0 2 2 2 0 Macoilin family DUF573 PF04504.14 EEA23425.1 - 1 10.0 5.3 1 10.1 0.1 3.0 2 1 0 3 3 3 0 Protein of unknown function, DUF573 ABC_tran_CTD PF16326.5 EEA23425.1 - 5.6 7.3 5.9 1.6 9.0 1.9 2.1 2 0 0 2 2 2 0 ABC transporter C-terminal domain CorA PF01544.18 EEA23425.1 - 9.6 5.4 6.7 2.5 7.3 3.1 1.8 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein HSP70 PF00012.20 EEA23426.1 - 0.0014 16.9 0.2 0.0064 14.7 0.0 2.0 3 0 0 3 3 3 1 Hsp70 protein SSI PF00720.17 EEA23426.1 - 0.12 12.4 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Subtilisin inhibitor-like Aldedh PF00171.22 EEA23427.1 - 2.8e-155 517.3 0.0 3.2e-155 517.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA23427.1 - 0.00019 20.9 0.0 0.0018 17.7 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) Helicase_C PF00271.31 EEA23428.1 - 1.5e-12 47.8 0.0 2.6e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Abhydro_lipase PF04083.16 EEA23429.1 - 2.2e-20 72.0 0.0 4.6e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EEA23429.1 - 6.3e-07 29.3 0.1 7.7e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA23429.1 - 0.0099 15.2 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 HDV_ag PF01517.18 EEA23429.1 - 0.083 12.7 0.6 0.2 11.4 0.6 1.6 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Chlorophyllase2 PF12740.7 EEA23429.1 - 0.19 10.6 0.0 1.2 7.9 0.0 1.9 2 0 0 2 2 2 0 Chlorophyllase enzyme Phosphoesterase PF04185.14 EEA23430.1 - 3.2e-61 207.5 1.6 7.2e-61 206.3 1.6 1.6 1 1 0 1 1 1 1 Phosphoesterase family Fungal_trans PF04082.18 EEA23431.1 - 3.6e-06 26.2 1.1 3.6e-06 26.2 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23431.1 - 0.0027 17.8 5.1 0.0058 16.7 5.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo70 PF03081.15 EEA23431.1 - 0.013 14.6 0.2 0.34 9.9 0.3 2.1 2 0 0 2 2 2 0 Exo70 exocyst complex subunit PSI_integrin PF17205.3 EEA23431.1 - 0.74 9.6 4.3 0.96 9.2 2.5 2.0 2 0 0 2 2 2 0 Integrin plexin domain HrpJ PF07201.11 EEA23431.1 - 0.89 9.9 3.8 2.2 8.6 3.8 1.6 1 0 0 1 1 1 0 HrpJ-like domain CDH-cyt PF16010.5 EEA23432.1 - 6.1e-25 88.0 0.3 6.1e-25 88.0 0.3 1.6 1 1 1 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 EEA23432.1 - 0.00081 19.5 12.3 0.0021 18.2 12.3 1.8 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DOMON PF03351.17 EEA23432.1 - 0.0068 16.6 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 DOMON domain CECR6_TMEM121 PF14997.6 EEA23432.1 - 0.032 14.1 0.5 0.47 10.3 0.3 2.0 1 1 0 2 2 2 0 CECR6/TMEM121 family Glycophorin_A PF01102.18 EEA23432.1 - 0.044 14.0 1.6 11 6.3 0.5 2.4 2 0 0 2 2 2 0 Glycophorin A DUF1129 PF06570.11 EEA23432.1 - 0.4 10.1 4.7 7 6.1 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) DUF508 PF04370.12 EEA23432.1 - 0.92 9.2 6.7 1.7 8.4 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF508) SR-25 PF10500.9 EEA23432.1 - 7.8 6.0 8.3 11 5.6 8.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Copper-bind PF00127.20 EEA23433.1 - 0.00085 19.7 0.0 0.0018 18.7 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EEA23433.1 - 0.014 15.5 0.0 0.031 14.4 0.0 1.5 1 1 0 1 1 1 0 Cupredoxin-like domain Tyrosinase PF00264.20 EEA23434.1 - 2e-53 182.0 1.9 2e-53 182.0 1.9 2.0 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EEA23434.1 - 1.7e-23 83.6 0.0 3e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Metallophos PF00149.28 EEA23435.1 - 2.3e-07 31.5 0.4 4.9e-07 30.5 0.4 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase eIF-3_zeta PF05091.12 EEA23436.1 - 3.2e-210 699.5 0.0 4e-210 699.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) bZIP_2 PF07716.15 EEA23437.1 - 0.0029 17.7 11.8 0.11 12.6 5.1 2.4 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EEA23437.1 - 0.0071 16.4 11.9 0.019 15.0 11.9 1.7 1 1 0 1 1 1 1 bZIP transcription factor SIKE PF05769.11 EEA23437.1 - 0.013 15.5 4.7 0.027 14.4 4.7 1.4 1 0 0 1 1 1 0 SIKE family HMMR_N PF15905.5 EEA23437.1 - 0.014 14.9 2.6 0.022 14.2 2.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Aminopep PF10023.9 EEA23437.1 - 0.18 11.1 3.3 0.28 10.5 3.3 1.2 1 0 0 1 1 1 0 Putative aminopeptidase DUF4407 PF14362.6 EEA23437.1 - 0.39 10.0 1.6 0.62 9.4 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TEX13 PF15186.6 EEA23437.1 - 2.4 7.8 5.3 4 7.1 5.3 1.3 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family DUF148 PF02520.17 EEA23437.1 - 5.5 7.1 8.2 1.5 9.0 4.8 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF148 APG6_N PF17675.1 EEA23438.1 - 0.33 11.5 6.2 0.8 10.2 6.2 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region MFS_1 PF07690.16 EEA23439.1 - 5e-45 154.0 51.2 1.9e-42 145.4 28.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23439.1 - 1e-10 41.1 26.8 1.9e-10 40.2 9.8 3.1 2 1 0 3 3 3 3 Sugar (and other) transporter BT1 PF03092.16 EEA23439.1 - 0.074 11.3 15.6 0.011 14.0 4.3 2.8 3 0 0 3 3 3 0 BT1 family TMEM43 PF07787.12 EEA23439.1 - 6.8 6.0 7.1 1.5 8.2 1.3 2.7 3 1 0 3 3 3 0 Transmembrane protein 43 MFS_1 PF07690.16 EEA23440.1 - 3.6e-29 101.8 16.9 4.3e-29 101.5 16.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EEA23441.1 - 0.0062 15.5 20.3 0.061 12.2 5.4 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily gag_pre-integrs PF13976.6 EEA23442.1 - 6e-08 32.4 0.6 2e-07 30.7 0.0 2.1 2 0 0 2 2 2 1 GAG-pre-integrase domain REV1_C PF16727.5 EEA23442.1 - 0.33 11.4 4.0 7 7.1 0.3 2.6 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain RVT_2 PF07727.14 EEA23443.1 - 5.6e-29 101.5 0.2 6.8e-28 97.9 0.2 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Orthopox_F14 PF06076.12 EEA23443.1 - 0.052 13.8 2.8 0.15 12.4 2.8 1.8 1 0 0 1 1 1 0 Orthopoxvirus F14 protein Flg_hook PF02120.16 EEA23443.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK NmrA PF05368.13 EEA23444.1 - 2.4e-26 92.7 0.0 3.6e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA23444.1 - 2.9e-16 59.9 0.0 6.5e-16 58.8 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EEA23444.1 - 0.00047 19.4 0.1 0.00066 18.9 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain HTH_56 PF18662.1 EEA23444.1 - 0.069 13.2 0.0 0.3 11.2 0.0 2.0 2 0 0 2 2 2 0 Cch helix turn helix domain Endotoxin_C2 PF18449.1 EEA23444.1 - 0.14 12.6 1.4 0.6 10.5 0.5 2.4 2 1 0 2 2 2 0 Delta endotoxin OCRE PF17780.1 EEA23444.1 - 3.6 7.7 5.4 2.7 8.1 0.4 2.5 2 1 0 2 2 2 0 OCRE domain AMP-binding PF00501.28 EEA23445.1 - 2.1e-49 168.3 0.1 2.8e-49 167.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF1772 PF08592.11 EEA23446.1 - 1.8e-22 80.1 4.5 2.7e-22 79.6 4.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) EthD PF07110.11 EEA23447.1 - 1.2e-19 71.3 2.7 1.8e-19 70.7 2.7 1.3 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EEA23447.1 - 2.9e-05 24.5 0.5 5.7e-05 23.5 0.5 1.6 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase p47_phox_C PF08944.11 EEA23447.1 - 0.0083 15.5 0.4 0.021 14.3 0.4 1.5 1 0 0 1 1 1 1 NADPH oxidase subunit p47Phox, C terminal domain ketoacyl-synt PF00109.26 EEA23448.1 - 2.3e-71 240.3 0.0 4.1e-71 239.5 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EEA23448.1 - 5.4e-45 154.0 0.0 4.8e-44 150.9 0.0 2.4 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EEA23448.1 - 4.9e-32 111.7 0.0 2.4e-31 109.4 0.0 2.0 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA23448.1 - 8.3e-22 77.4 0.7 2.6e-21 75.8 0.7 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EEA23448.1 - 3.7e-11 43.2 1.3 1e-10 41.8 1.3 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EEA23448.1 - 8.5e-11 42.3 0.1 2.6e-10 40.8 0.0 1.9 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 EEA23448.1 - 4.2e-09 36.1 0.0 9.2e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EEA23448.1 - 0.00054 19.4 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Aldo_ket_red PF00248.21 EEA23449.1 - 4.2e-51 173.9 0.0 2.1e-50 171.6 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family adh_short PF00106.25 EEA23450.1 - 3.2e-39 134.4 2.6 3.2e-39 134.4 2.6 1.5 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23450.1 - 1e-29 103.7 3.3 3.4e-29 102.1 2.4 1.9 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EEA23450.1 - 1.1e-07 31.5 0.1 1.9e-06 27.5 0.3 2.0 1 1 0 2 2 2 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EEA23450.1 - 4.6e-06 26.4 0.3 8.9e-06 25.4 0.1 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EEA23450.1 - 4.7e-06 26.6 0.0 9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA23450.1 - 0.0006 19.3 0.2 0.0021 17.6 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EEA23450.1 - 0.00087 19.8 0.1 0.0026 18.3 0.1 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EEA23450.1 - 0.0015 18.7 0.1 0.0032 17.6 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_zinc_N PF00107.26 EEA23450.1 - 0.0034 17.3 0.1 0.007 16.3 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DFP PF04127.15 EEA23450.1 - 0.0055 16.6 0.2 0.012 15.5 0.2 1.5 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein RmlD_sub_bind PF04321.17 EEA23450.1 - 0.011 14.8 0.4 0.11 11.6 0.1 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain 2-Hacid_dh_C PF02826.19 EEA23450.1 - 0.026 13.9 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA23450.1 - 0.035 14.0 0.1 0.062 13.2 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PALP PF00291.25 EEA23450.1 - 0.049 13.1 0.1 0.07 12.5 0.1 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme ApbA PF02558.16 EEA23450.1 - 0.1 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EEA23450.1 - 0.11 11.7 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Eno-Rase_NADH_b PF12242.8 EEA23450.1 - 0.13 12.1 0.1 0.31 10.8 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1971 PF09313.11 EEA23450.1 - 0.16 12.0 0.0 3.8 7.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1971) Methyltransf_2 PF00891.18 EEA23451.1 - 1.6e-21 76.6 0.0 2.5e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation PF08100.11 EEA23451.1 - 0.0025 17.8 0.1 0.019 15.0 0.0 2.3 2 0 0 2 2 2 1 Dimerisation domain Raf1_HTH PF18579.1 EEA23451.1 - 0.05 13.3 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain Cu-oxidase_3 PF07732.15 EEA23452.1 - 1.2e-06 28.5 0.0 2.3e-06 27.6 0.0 1.4 1 1 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 EEA23453.1 - 1.5e-24 86.9 0.7 1.9e-20 73.6 0.0 3.0 2 1 1 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA23453.1 - 6.2e-15 55.1 0.3 2.1e-13 50.2 0.2 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EEA23453.1 - 5.4e-06 26.4 1.8 2.2e-05 24.4 1.4 2.3 2 0 0 2 2 2 1 Multicopper oxidase GMC_oxred_N PF00732.19 EEA23455.1 - 1.1e-32 113.7 0.0 3.2e-31 108.8 0.0 2.1 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA23455.1 - 3.5e-29 102.2 0.0 5.6e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EEA23455.1 - 1.9e-05 24.8 0.1 6.7e-05 23.1 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA23455.1 - 2e-05 23.8 0.2 3.2e-05 23.2 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EEA23455.1 - 3.9e-05 23.0 0.1 0.0001 21.7 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA23455.1 - 0.00032 20.1 0.1 0.00049 19.4 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA23455.1 - 0.00084 19.0 0.2 0.0017 18.0 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA23455.1 - 0.001 18.4 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EEA23455.1 - 0.0011 19.2 0.0 0.0024 18.1 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain HI0933_like PF03486.14 EEA23455.1 - 0.0025 16.6 0.1 0.0038 16.0 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_9 PF13454.6 EEA23455.1 - 0.0066 16.5 0.1 0.14 12.2 0.1 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EEA23455.1 - 0.0095 15.1 0.2 0.015 14.4 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EEA23455.1 - 0.025 13.8 0.1 0.043 13.1 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 EEA23455.1 - 0.073 13.6 0.3 0.25 11.9 0.1 2.0 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA23455.1 - 0.099 12.0 0.4 0.2 11.0 0.2 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_DMAT PF11991.8 EEA23456.1 - 3.4e-99 332.7 0.0 3.9e-99 332.5 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase adh_short PF00106.25 EEA23457.1 - 2.4e-36 125.1 0.1 2.9e-36 124.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23457.1 - 4.9e-32 111.4 0.0 6.4e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23457.1 - 1.8e-10 41.0 0.0 2.6e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA23457.1 - 8.4e-05 21.8 0.1 0.00017 20.9 0.1 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA23457.1 - 0.0097 15.4 0.1 0.32 10.4 0.1 2.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Questin_oxidase PF14027.6 EEA23458.1 - 9e-89 298.4 0.3 1.1e-88 298.1 0.3 1.0 1 0 0 1 1 1 1 Questin oxidase-like NAD_binding_10 PF13460.6 EEA23459.1 - 1.8e-14 54.0 0.0 2.3e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA23459.1 - 5.1e-08 32.8 0.0 9.1e-08 31.9 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EEA23459.1 - 0.00027 20.0 0.0 0.00032 19.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.17 EEA23459.1 - 0.0019 18.8 0.0 0.0035 17.9 0.0 1.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EEA23459.1 - 0.0088 16.2 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.21 EEA23459.1 - 0.013 15.0 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA23459.1 - 0.018 14.2 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 Male sterility protein Polysacc_synt_2 PF02719.15 EEA23459.1 - 0.019 14.1 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein KR PF08659.10 EEA23459.1 - 0.055 13.4 0.0 0.082 12.8 0.0 1.2 1 0 0 1 1 1 0 KR domain Semialdhyde_dh PF01118.24 EEA23459.1 - 0.078 13.4 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EEA23459.1 - 0.088 12.2 0.0 0.19 11.1 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 EEA23459.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ABM PF03992.16 EEA23460.1 - 0.029 14.5 0.0 0.036 14.2 0.0 1.3 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase p450 PF00067.22 EEA23461.1 - 6e-47 160.4 0.0 6.6e-37 127.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 PEGSRP PF07623.11 EEA23461.1 - 0.016 14.9 0.0 0.071 12.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1584) Herpes_IE68 PF02479.16 EEA23461.1 - 0.02 14.5 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus immediate early protein adh_short PF00106.25 EEA23462.1 - 1.9e-35 122.1 0.1 4.3e-35 121.0 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23462.1 - 1.4e-23 83.7 0.0 2e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23462.1 - 5.7e-10 39.4 0.0 7.2e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA23462.1 - 9e-05 22.1 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA23462.1 - 0.00023 20.4 0.0 0.00049 19.3 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EEA23462.1 - 0.00098 19.1 0.1 0.0016 18.4 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EEA23462.1 - 0.0024 17.3 0.0 0.0035 16.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EEA23462.1 - 0.017 14.2 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain NAD_binding_4 PF07993.12 EEA23462.1 - 0.086 12.0 0.1 0.12 11.5 0.1 1.4 1 1 0 1 1 1 0 Male sterility protein Lactamase_B PF00753.27 EEA23463.1 - 4.4e-15 56.2 6.9 6.1e-14 52.5 6.9 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 EEA23463.1 - 0.00016 21.5 0.6 0.00069 19.6 0.0 2.3 3 0 0 3 3 3 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 EEA23463.1 - 0.0012 18.4 0.7 0.002 17.7 0.7 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain adh_short_C2 PF13561.6 EEA23464.1 - 3.3e-53 180.6 1.1 4.2e-53 180.3 1.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA23464.1 - 1.2e-46 158.6 1.7 1.6e-46 158.2 1.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA23464.1 - 3.4e-10 40.1 0.2 4.2e-10 39.8 0.2 1.1 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 EEA23464.1 - 0.045 13.1 0.2 0.12 11.8 0.2 1.6 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 EEA23464.1 - 0.096 12.1 0.3 0.49 9.8 0.3 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family AflR PF08493.10 EEA23465.1 - 3.2e-46 158.1 12.5 5.3e-46 157.4 12.5 1.2 1 0 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EEA23465.1 - 7.4e-08 32.4 9.3 1.3e-07 31.6 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transferase PF02458.15 EEA23466.1 - 2.4e-22 79.2 0.0 4.2e-19 68.5 0.0 2.1 2 0 0 2 2 2 2 Transferase family Rrf2 PF02082.20 EEA23467.1 - 0.015 15.6 0.0 0.044 14.1 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator Scytalone_dh PF02982.14 EEA23468.1 - 9.7e-68 227.0 2.0 1.1e-67 226.8 2.0 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EEA23468.1 - 1.2e-07 31.9 0.3 1.4e-07 31.7 0.3 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EEA23468.1 - 0.065 13.6 0.9 2.3 8.6 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 EEA23468.1 - 0.1 12.8 0.8 0.31 11.3 0.8 1.8 1 1 0 1 1 1 0 SnoaL-like domain DHDPS PF00701.22 EEA23470.1 - 1.7e-40 138.5 0.0 2.1e-40 138.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Aminotran_1_2 PF00155.21 EEA23471.1 - 3.5e-62 210.7 0.0 4.2e-62 210.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4597 PF15366.6 EEA23472.1 - 0.0098 15.6 0.7 0.018 14.7 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4597) Caudo_TAP PF02413.17 EEA23472.1 - 0.053 13.7 1.9 0.072 13.2 1.9 1.3 1 1 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Hydantoinase_B PF02538.14 EEA23474.1 - 2.2e-211 702.8 0.1 2.8e-211 702.4 0.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EEA23474.1 - 2.2e-100 335.7 0.1 4.6e-100 334.6 0.0 1.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EEA23474.1 - 4.9e-59 199.0 0.2 6.1e-57 192.2 0.0 2.3 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Proteasome_A_N PF10584.9 EEA23474.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature DUF3546 PF12066.8 EEA23476.1 - 5.6e-30 103.8 3.1 5.6e-30 103.8 3.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) DUF4187 PF13821.6 EEA23476.1 - 4.6e-12 45.5 0.1 1.1e-11 44.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.13 EEA23476.1 - 7.7e-11 42.7 2.0 7.7e-11 42.7 2.0 2.3 1 1 2 3 3 3 1 Arsenite-resistance protein 2 CBFB_NFYA PF02045.15 EEA23477.1 - 1.5e-28 99.2 4.6 3e-28 98.2 4.6 1.5 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B TFIIA PF03153.13 EEA23477.1 - 0.00047 20.3 24.6 0.00056 20.0 24.6 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Hus1 PF04005.12 EEA23477.1 - 0.045 12.9 0.0 0.076 12.1 0.0 1.3 1 0 0 1 1 1 0 Hus1-like protein p450 PF00067.22 EEA23478.1 - 1.2e-13 50.7 0.1 5.3e-09 35.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 NmrA PF05368.13 EEA23480.1 - 1.3e-22 80.6 0.0 1.6e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA23480.1 - 5.1e-19 68.9 0.0 6.9e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA23480.1 - 7.3e-06 25.6 0.0 0.00091 18.8 0.0 2.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EEA23480.1 - 0.0017 18.5 0.1 0.003 17.7 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 EEA23480.1 - 0.004 17.4 0.0 0.023 15.0 0.0 2.2 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Ldh_1_N PF00056.23 EEA23480.1 - 0.0082 16.2 0.1 0.016 15.3 0.1 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Isochorismatase PF00857.20 EEA23480.1 - 0.015 15.4 0.0 0.94 9.6 0.0 2.4 2 0 0 2 2 2 0 Isochorismatase family Semialdhyde_dh PF01118.24 EEA23480.1 - 0.07 13.6 0.1 0.14 12.6 0.1 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Caps_synth PF05704.12 EEA23481.1 - 7.3e-14 51.8 0.0 1.5e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 EEA23481.1 - 4.2e-05 24.1 0.0 8.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif p450 PF00067.22 EEA23482.1 - 5.9e-26 91.2 0.2 1.1e-16 60.7 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Transferase PF02458.15 EEA23483.1 - 3.8e-19 68.7 0.0 9.1e-18 64.1 0.0 2.1 2 0 0 2 2 2 2 Transferase family Transferase PF02458.15 EEA23484.1 - 4.5e-18 65.1 0.0 5.6e-18 64.8 0.0 1.0 1 0 0 1 1 1 1 Transferase family DUF1593 PF07632.11 EEA23485.1 - 1.4e-95 319.6 0.0 2e-95 319.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 EEA23485.1 - 0.039 12.7 0.0 0.055 12.2 0.0 1.2 1 0 0 1 1 1 0 REJ domain ADH_N PF08240.12 EEA23486.1 - 1.2e-30 105.6 0.4 1.9e-30 104.9 0.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA23486.1 - 5e-13 49.2 0.0 8.7e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA23486.1 - 1.6e-06 27.8 0.2 1.7e-05 24.4 0.2 2.3 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus TrkA_N PF02254.18 EEA23486.1 - 0.12 12.7 0.0 0.43 10.9 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain Aldo_ket_red PF00248.21 EEA23487.1 - 1.5e-44 152.4 0.0 2.1e-44 151.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Zn_clus PF00172.18 EEA23488.1 - 0.016 15.3 0.7 0.031 14.4 0.7 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA23489.1 - 3.3e-14 52.5 0.5 7.8e-14 51.3 0.5 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 EEA23489.1 - 0.064 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain MIT PF04212.18 EEA23489.1 - 0.12 12.4 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Sugar_tr PF00083.24 EEA23490.1 - 3.4e-73 247.1 23.0 4.1e-73 246.8 23.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23490.1 - 1.1e-18 67.3 28.4 1.1e-18 67.3 28.4 1.9 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23491.1 - 6.4e-80 269.2 20.9 7.9e-80 268.9 20.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23491.1 - 1e-34 120.0 42.8 1.4e-31 109.7 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA23491.1 - 0.00072 18.1 7.1 0.0037 15.7 0.9 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) ATS3 PF06232.11 EEA23491.1 - 0.017 15.0 0.3 0.037 13.9 0.3 1.4 1 0 0 1 1 1 0 Embryo-specific protein 3, (ATS3) Phage_holin_3_2 PF04550.12 EEA23491.1 - 0.043 14.4 0.6 0.12 12.9 0.6 1.7 1 0 0 1 1 1 0 Phage holin family 2 YqfD PF06898.11 EEA23491.1 - 1.4 7.6 3.4 5.3 5.8 0.1 2.8 3 0 0 3 3 3 0 Putative stage IV sporulation protein YqfD DUF3792 PF12670.7 EEA23491.1 - 9.2 6.5 17.1 0.079 13.1 1.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) DUF4188 PF13826.6 EEA23492.1 - 5.8e-39 133.1 0.4 8.1e-39 132.6 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) ABM PF03992.16 EEA23492.1 - 0.041 14.0 0.4 0.38 10.9 0.2 2.6 3 0 0 3 3 3 0 Antibiotic biosynthesis monooxygenase Kinesin PF00225.23 EEA23493.1 - 4.9e-108 361.0 0.0 7.7e-108 360.4 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 EEA23493.1 - 1.6e-44 152.3 0.0 3.9e-44 151.0 0.0 1.7 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 EEA23493.1 - 1.2e-37 129.8 10.4 2.4e-31 109.3 0.3 3.1 3 1 1 4 4 4 2 Kinesin-associated Microtub_bd PF16796.5 EEA23493.1 - 7.1e-25 87.7 0.0 2.1e-24 86.2 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.26 EEA23493.1 - 2e-07 31.2 0.1 1.6e-06 28.3 0.1 2.6 2 0 0 2 2 2 1 FHA domain KIF1B PF12423.8 EEA23493.1 - 2.8e-07 30.9 0.3 1.1e-06 28.9 0.1 2.3 2 0 0 2 2 2 1 Kinesin protein 1B PH PF00169.29 EEA23493.1 - 5.1e-06 27.0 0.0 1.9e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 PH domain AAA_22 PF13401.6 EEA23493.1 - 0.085 13.1 1.1 1 9.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain Selenoprotein_S PF06936.11 EEA23493.1 - 0.26 11.1 8.4 0.88 9.3 8.4 1.8 1 0 0 1 1 1 0 Selenoprotein S (SelS) DUF334 PF03904.13 EEA23493.1 - 0.53 9.8 3.8 3 7.3 3.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF334) NmrA PF05368.13 EEA23494.1 - 1e-53 182.3 0.5 1.4e-53 181.9 0.5 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA23494.1 - 1.5e-18 67.3 0.1 2.1e-18 66.9 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA23494.1 - 3e-06 26.5 0.0 4.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA23494.1 - 0.0083 15.6 0.1 0.013 14.9 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EEA23494.1 - 0.089 13.1 0.1 0.5 10.6 0.1 2.2 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain SOBP PF15279.6 EEA23495.1 - 0.36 11.4 4.8 0.41 11.2 4.8 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein PP2C_2 PF13672.6 EEA23495.1 - 0.83 9.3 5.1 1 8.9 5.1 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C DNase_NucA_NucB PF14040.6 EEA23496.1 - 1.4e-08 35.1 0.7 2.3e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Deoxyribonuclease NucA/NucB DUF3713 PF12506.8 EEA23496.1 - 0.18 12.1 0.0 0.18 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) DUF515 PF04415.12 EEA23496.1 - 1 7.7 5.8 1.6 7.0 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Glyco_transf_90 PF05686.12 EEA23497.1 - 4.3e-28 98.3 0.2 6e-28 97.9 0.2 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 EEA23497.1 - 0.0083 16.5 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 BCS1_N PF08740.11 EEA23498.1 - 1.3e-48 165.5 0.6 2.5e-48 164.6 0.6 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EEA23498.1 - 2e-17 63.8 0.0 3.1e-08 34.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA23498.1 - 0.0046 17.3 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EEA23498.1 - 0.0072 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 EEA23498.1 - 0.043 13.4 0.0 0.096 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EEA23498.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF3342 PF11822.8 EEA23498.1 - 0.14 12.4 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) AAA_5 PF07728.14 EEA23498.1 - 0.18 11.8 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Glyco_hydro_43 PF04616.14 EEA23499.1 - 2.7e-32 112.3 0.0 3.7e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Na_H_Exchanger PF00999.21 EEA23500.1 - 3e-08 32.9 6.9 0.00059 18.7 0.7 3.0 3 0 0 3 3 3 3 Sodium/hydrogen exchanger family Na_H_Exchanger PF00999.21 EEA23501.1 - 6.5e-25 87.7 14.5 8e-25 87.4 14.5 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Sbt_1 PF05982.12 EEA23501.1 - 0.011 15.0 11.0 0.018 14.3 10.8 1.4 1 1 1 2 2 2 0 Na+-dependent bicarbonate transporter superfamily F-box-like PF12937.7 EEA23502.1 - 0.063 13.2 0.8 0.37 10.7 0.4 2.5 2 0 0 2 2 2 0 F-box-like MFS_1 PF07690.16 EEA23504.1 - 3.3e-26 92.0 54.4 3.3e-26 92.0 54.4 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Zn_clus PF00172.18 EEA23504.1 - 2.7e-08 33.8 2.0 4.9e-08 33.0 2.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AflR PF08493.10 EEA23504.1 - 4e-07 29.8 2.1 4e-07 29.8 2.1 1.7 2 0 0 2 2 2 1 Aflatoxin regulatory protein TRI12 PF06609.13 EEA23504.1 - 4.8e-07 28.6 4.7 4.8e-07 28.6 4.7 2.2 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) p450 PF00067.22 EEA23504.1 - 4.2e-05 22.5 0.0 6.4e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 HTH_27 PF13463.6 EEA23505.1 - 0.096 13.2 0.1 0.24 11.9 0.0 1.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain Methyltransf_2 PF00891.18 EEA23506.1 - 4.4e-11 42.5 0.0 4.8e-11 42.3 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_33 PF10017.9 EEA23506.1 - 0.063 12.4 0.0 3 6.9 0.0 2.0 1 1 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent Phosphodiest PF01663.22 EEA23507.1 - 6.6e-87 292.4 0.2 8.8e-87 292.0 0.2 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EEA23507.1 - 9.4e-05 21.9 0.1 0.098 12.0 0.1 2.3 1 1 0 1 1 1 1 Sulfatase Git3 PF11710.8 EEA23509.1 - 1e-10 41.8 7.4 1e-10 41.8 7.4 1.7 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EEA23509.1 - 6.6e-09 35.7 0.8 1.8e-08 34.4 0.1 2.1 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Frizzled PF01534.17 EEA23509.1 - 6.4e-05 22.2 7.9 0.012 14.6 0.0 2.2 2 0 0 2 2 2 2 Frizzled/Smoothened family membrane region Fip1 PF05182.13 EEA23509.1 - 0.33 10.5 1.8 0.32 10.6 0.4 1.6 2 0 0 2 2 2 0 Fip1 motif DUF4834 PF16118.5 EEA23509.1 - 8.7 7.4 5.8 0.77 10.8 0.2 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) HLH PF00010.26 EEA23512.1 - 2e-15 56.5 1.1 5.7e-15 55.0 0.9 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Lzipper-MIP1 PF14389.6 EEA23512.1 - 0.063 13.6 3.0 0.1 12.9 0.7 2.5 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 YabA PF06156.13 EEA23512.1 - 0.08 13.6 3.4 0.14 12.8 2.8 1.7 1 1 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 EEA23512.1 - 0.12 12.8 4.3 0.29 11.6 4.3 1.6 1 0 0 1 1 1 0 Cell division protein ZapB RNR_Alpha PF17975.1 EEA23512.1 - 0.15 12.5 0.9 0.33 11.5 0.9 1.5 1 0 0 1 1 1 0 Ribonucleotide reductase alpha domain HALZ PF02183.18 EEA23512.1 - 0.16 12.2 0.9 0.37 11.1 0.9 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper APG6_N PF17675.1 EEA23512.1 - 0.37 11.3 4.7 0.65 10.5 4.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Rootletin PF15035.6 EEA23512.1 - 0.4 10.7 12.2 1.8 8.6 1.5 2.4 2 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion SlyX PF04102.12 EEA23512.1 - 0.85 10.3 4.9 0.5 11.0 2.4 1.9 2 0 0 2 2 2 0 SlyX DUF1640 PF07798.11 EEA23512.1 - 3.8 7.5 6.7 1.2 9.1 2.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Neur_chan_memb PF02932.16 EEA23512.1 - 6.9 6.7 7.2 0.97 9.4 2.4 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Mid2 PF04478.12 EEA23513.1 - 0.035 13.9 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Ofd1_CTDD PF10637.9 EEA23514.1 - 1.6e-96 322.6 0.0 5.1e-93 311.1 0.0 2.4 3 0 0 3 3 3 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EEA23514.1 - 2.3e-26 92.3 0.0 6.4e-26 90.9 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EEA23514.1 - 6e-14 52.7 0.0 1.3e-13 51.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RVT_1 PF00078.27 EEA23515.1 - 1e-26 93.8 0.0 1.8e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA23515.1 - 1.2e-22 80.0 1.9 1.5e-22 79.7 0.1 2.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EEA23515.1 - 2.4e-13 50.5 0.0 6.3e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 RNase H Exo_endo_phos PF03372.23 EEA23515.1 - 7.8e-05 22.3 0.1 0.00022 20.8 0.1 1.8 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EEA23515.1 - 0.21 11.8 8.1 0.019 15.0 1.9 2.3 2 0 0 2 2 2 0 Zinc knuckle DUF4300 PF14133.6 EEA23515.1 - 0.24 11.1 0.2 0.51 10.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) Sod_Fe_C PF02777.18 EEA23516.1 - 2e-32 111.4 0.4 6.5e-32 109.8 0.3 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EEA23516.1 - 5.8e-24 84.4 1.4 1.5e-23 83.1 1.4 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Aminotran_1_2 PF00155.21 EEA23516.1 - 1.9e-23 83.2 0.0 4.8e-23 81.9 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II ECH_1 PF00378.20 EEA23517.1 - 2e-21 76.5 0.0 2.6e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA23517.1 - 5.6e-06 26.1 0.0 6.9e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EEA23517.1 - 0.015 15.2 0.0 6.3 6.7 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 Nucleo_P87 PF07267.11 EEA23518.1 - 0.22 10.4 3.9 0.3 9.9 3.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ECH_1 PF00378.20 EEA23519.1 - 1.7e-21 76.7 0.0 2.2e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA23519.1 - 4.5e-06 26.4 0.0 6e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EEA23519.1 - 0.012 15.5 0.0 5.9 6.8 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 SIT PF15330.6 EEA23520.1 - 2.1 8.8 3.7 18 5.8 0.8 2.4 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT TAFII55_N PF04658.13 EEA23521.1 - 3e-53 179.8 0.2 6.3e-53 178.8 0.2 1.6 1 0 0 1 1 1 1 TAFII55 protein conserved region Bromo_TP PF07524.13 EEA23522.1 - 1.6e-09 37.6 0.0 3.8e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EEA23522.1 - 0.00072 19.6 0.0 0.0012 19.0 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit BRO1 PF03097.18 EEA23523.1 - 1.2e-06 27.6 0.0 1.8e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain UPF0767 PF15990.5 EEA23523.1 - 0.13 12.5 0.0 3.8 7.7 0.0 2.6 2 0 0 2 2 2 0 UPF0767 family FliH PF02108.16 EEA23523.1 - 0.16 12.0 0.1 7.4 6.7 0.0 2.2 2 0 0 2 2 2 0 Flagellar assembly protein FliH Ank_2 PF12796.7 EEA23524.1 - 3.3e-23 82.1 0.1 1.1e-09 38.8 0.0 4.9 4 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA23524.1 - 9.6e-17 59.4 2.5 0.04 14.5 0.0 7.5 8 0 0 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 EEA23524.1 - 7.1e-15 55.2 0.5 0.1 13.2 0.0 6.5 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA23524.1 - 4.4e-14 52.4 1.8 0.00034 20.9 0.0 6.6 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA23524.1 - 1.2e-13 50.8 1.2 0.18 12.3 0.0 7.0 7 0 0 7 7 7 3 Ankyrin repeat F-box-like PF12937.7 EEA23524.1 - 0.024 14.5 0.1 0.055 13.4 0.1 1.6 1 0 0 1 1 1 0 F-box-like NDUFB10 PF10249.9 EEA23524.1 - 0.028 14.9 0.0 0.08 13.4 0.0 1.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit 10 HET PF06985.11 EEA23525.1 - 3.9e-09 37.0 0.3 6.1e-07 29.9 0.0 2.7 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Glyco_transf_34 PF05637.12 EEA23526.1 - 4.7e-65 219.6 2.6 5.8e-65 219.3 1.1 2.0 2 0 0 2 2 2 1 galactosyl transferase GMA12/MNN10 family SNF2_N PF00176.23 EEA23526.1 - 3.1e-58 197.2 0.0 4.7e-58 196.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain p450 PF00067.22 EEA23526.1 - 1.3e-20 73.6 0.0 1.3e-17 63.7 0.0 2.8 1 1 1 2 2 2 2 Cytochrome P450 Helicase_C PF00271.31 EEA23526.1 - 4.7e-13 49.5 0.0 2e-12 47.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA23526.1 - 1.7e-06 28.1 0.0 3.2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA23526.1 - 0.0016 17.7 0.0 0.0031 16.8 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EEA23526.1 - 0.0017 18.0 0.0 0.0093 15.7 0.0 2.0 1 1 0 1 1 1 1 SWI2/SNF2 ATPase NACHT PF05729.12 EEA23527.1 - 6.1e-09 36.0 0.0 1.4e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA23527.1 - 1.4e-08 35.3 1.1 4.1e-07 30.6 0.0 3.0 2 0 0 2 2 2 1 AAA ATPase domain KAP_NTPase PF07693.14 EEA23527.1 - 4.5e-07 29.4 1.0 0.006 15.9 0.0 3.1 3 0 0 3 3 3 2 KAP family P-loop domain AAA_22 PF13401.6 EEA23527.1 - 0.0002 21.7 0.0 0.0011 19.2 0.0 2.2 1 1 1 2 2 2 1 AAA domain NB-ARC PF00931.22 EEA23527.1 - 0.0012 18.1 0.1 0.005 16.1 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain Parvo_NS1 PF01057.17 EEA23527.1 - 0.0079 15.3 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA PF00004.29 EEA23527.1 - 0.0089 16.4 0.2 0.063 13.7 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA23527.1 - 0.013 15.5 0.0 0.043 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EEA23527.1 - 0.027 14.0 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PPV_E1_C PF00519.17 EEA23527.1 - 0.03 13.2 0.0 0.053 12.3 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase 6PF2K PF01591.18 EEA23527.1 - 0.048 13.0 0.4 0.66 9.2 0.0 2.6 3 0 0 3 3 3 0 6-phosphofructo-2-kinase DUF2075 PF09848.9 EEA23527.1 - 0.076 12.2 1.2 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KinB_sensor PF16767.5 EEA23527.1 - 0.097 13.1 0.1 0.097 13.1 0.1 3.0 3 0 0 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB RNA_helicase PF00910.22 EEA23527.1 - 0.13 12.6 0.1 0.45 10.9 0.0 2.0 2 0 0 2 2 1 0 RNA helicase adh_short PF00106.25 EEA23528.1 - 9.9e-25 87.1 0.0 2.8e-20 72.6 0.0 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23528.1 - 4.6e-16 59.1 0.0 3.4e-15 56.3 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23528.1 - 2.1e-06 27.8 0.1 3.1e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Pedibin PF08182.11 EEA23529.1 - 0.089 12.6 0.3 0.16 11.8 0.3 1.4 1 0 0 1 1 1 0 Pedibin/Hym-346 family Fungal_trans PF04082.18 EEA23531.1 - 3.2e-19 69.0 2.2 4.6e-19 68.5 2.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23531.1 - 9.1e-08 32.1 8.1 2e-07 31.0 8.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF790 PF05626.11 EEA23531.1 - 0.0096 14.7 0.1 0.014 14.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF790) Pec_lyase_C PF00544.19 EEA23532.1 - 4.7e-38 130.9 13.5 6.6e-38 130.4 13.5 1.2 1 0 0 1 1 1 1 Pectate lyase ABC2_membrane PF01061.24 EEA23533.1 - 1.6e-89 298.9 64.8 3.5e-46 157.3 29.2 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EEA23533.1 - 1.9e-35 122.4 0.0 1.4e-16 61.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EEA23533.1 - 8.6e-33 112.1 12.9 1.9e-30 104.6 0.0 4.2 4 0 0 4 4 4 2 CDR ABC transporter ABC_trans_N PF14510.6 EEA23533.1 - 1.2e-19 70.7 0.0 3.1e-19 69.4 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EEA23533.1 - 7.2e-08 31.9 14.8 7.2e-08 31.9 14.8 3.2 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_16 PF13191.6 EEA23533.1 - 1.2e-05 25.7 0.1 0.061 13.7 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EEA23533.1 - 1.9e-05 24.4 0.0 0.0003 20.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EEA23533.1 - 0.00011 22.1 0.0 0.035 14.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EEA23533.1 - 0.001 19.0 0.0 0.73 9.6 0.0 2.8 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA23533.1 - 0.006 16.0 0.0 0.31 10.4 0.0 2.7 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA23533.1 - 0.0064 16.2 0.5 0.76 9.6 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA23533.1 - 0.011 15.8 0.0 4.3 7.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EEA23533.1 - 0.04 14.4 0.1 0.4 11.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EEA23533.1 - 0.063 13.6 1.2 7.1 6.9 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EEA23533.1 - 0.12 12.5 0.1 8.4 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EEA23533.1 - 0.16 11.5 2.0 6.2 6.4 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EEA23533.1 - 0.2 11.6 1.0 18 5.2 0.2 2.9 2 0 0 2 2 2 0 NACHT domain MFS_1 PF07690.16 EEA23534.1 - 1.9e-30 106.0 44.6 3.5e-30 105.1 44.6 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4407 PF14362.6 EEA23534.1 - 0.26 10.6 3.3 7.5 5.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) zf-C2H2 PF00096.26 EEA23535.1 - 0.04 14.4 17.5 3.4 8.3 0.4 3.9 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA23535.1 - 0.057 14.3 10.8 0.38 11.7 1.4 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-TRAF PF02176.18 EEA23535.1 - 0.079 13.7 0.2 0.26 12.0 0.2 1.9 1 0 0 1 1 1 0 TRAF-type zinc finger Sybindin PF04099.12 EEA23536.1 - 4.3e-49 166.1 0.0 7e-49 165.4 0.0 1.3 1 1 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EEA23536.1 - 8.6e-09 35.6 0.0 1.5e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region VWA_2 PF13519.6 EEA23537.1 - 2.7e-21 76.2 0.0 9.7e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.14 EEA23537.1 - 2.8e-07 30.5 0.0 4.2e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 EEA23537.1 - 1.7e-06 28.4 0.2 2.6e-06 27.8 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 EEA23537.1 - 0.041 13.8 0.1 0.11 12.5 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif Nbl1_Borealin_N PF10444.9 EEA23538.1 - 9.3e-19 66.8 4.0 1.6e-18 66.1 4.0 1.4 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal Polyoma_coat PF00718.20 EEA23538.1 - 0.088 12.1 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Polyomavirus coat protein RhoGAP PF00620.27 EEA23539.1 - 1.4e-35 122.4 0.4 3.1e-35 121.3 0.4 1.6 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EEA23539.1 - 7.5e-32 109.4 37.6 4.1e-12 46.1 5.3 4.9 5 0 0 5 5 5 4 LIM domain 3Beta_HSD PF01073.19 EEA23540.1 - 3.1e-48 164.2 0.0 3.4e-47 160.8 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA23540.1 - 2.3e-16 60.0 0.1 2.1e-15 56.9 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA23540.1 - 5e-12 45.5 0.0 4.4e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EEA23540.1 - 4.4e-09 36.2 0.0 4.5e-06 26.3 0.0 3.2 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EEA23540.1 - 4.9e-05 22.6 0.0 0.00022 20.4 0.0 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EEA23540.1 - 0.021 14.0 0.1 0.36 9.9 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Pkinase PF00069.25 EEA23541.1 - 2.1e-59 201.0 0.0 1.3e-38 132.9 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23541.1 - 1.2e-27 96.9 0.0 2.3e-20 73.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EEA23541.1 - 2e-12 47.2 0.0 4e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EEA23541.1 - 1.9e-08 34.0 0.0 1.7e-05 24.3 0.0 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EEA23541.1 - 8.6e-05 22.6 0.0 0.0068 16.4 0.3 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA23541.1 - 0.00075 18.9 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EEA23541.1 - 0.016 14.2 0.0 0.029 13.3 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain PAS_9 PF13426.7 EEA23541.1 - 0.026 14.8 0.0 0.069 13.4 0.0 1.7 1 0 0 1 1 1 0 PAS domain RIO1 PF01163.22 EEA23541.1 - 0.054 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 EEA23541.1 - 0.13 11.3 0.1 0.25 10.3 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 EEA23541.1 - 0.22 11.1 0.2 13 5.3 0.0 2.5 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EEA23541.1 - 1.2 7.8 6.7 1.4 7.6 0.1 2.6 2 0 0 2 2 2 0 Fungal protein kinase SLAC1 PF03595.17 EEA23542.1 - 4.1e-92 308.9 54.4 4.6e-92 308.7 54.4 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel SLAC1 PF03595.17 EEA23543.1 - 2.2e-86 290.1 49.3 2.6e-86 289.8 49.3 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel SLAC1 PF03595.17 EEA23544.1 - 8.1e-90 301.4 53.1 1.1e-89 301.0 53.1 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel HTH_psq PF05225.16 EEA23546.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 EEA23546.1 - 0.0012 18.8 0.0 0.0026 17.7 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 EEA23546.1 - 0.011 15.6 0.3 0.038 13.8 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_24 PF13412.6 EEA23546.1 - 0.017 14.7 0.0 0.077 12.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 EEA23546.1 - 0.035 14.2 0.0 0.074 13.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain MarR PF01047.22 EEA23546.1 - 0.041 13.8 0.0 0.19 11.7 0.0 2.0 2 0 0 2 2 2 0 MarR family HTH_3 PF01381.22 EEA23546.1 - 0.051 13.6 0.1 0.26 11.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix HTH_AraC PF00165.23 EEA23546.1 - 0.052 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_Tnp_1_2 PF13022.6 EEA23546.1 - 0.064 13.4 0.0 0.094 12.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase AbiEi_4 PF13338.6 EEA23546.1 - 0.084 13.0 0.0 15 5.8 0.0 2.2 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin HTH_10 PF04967.12 EEA23546.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain Sigma70_r4 PF04545.16 EEA23546.1 - 0.16 11.5 0.0 0.4 10.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_4 PF13613.6 EEA23546.1 - 0.19 11.5 0.1 0.54 10.0 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease MS_channel PF00924.18 EEA23547.1 - 4e-24 85.3 0.9 7.5e-24 84.4 0.9 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 EEA23547.1 - 0.00026 20.3 0.1 0.00057 19.3 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EEA23547.1 - 0.00069 19.0 0.4 0.0016 17.8 0.4 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EEA23547.1 - 0.0013 18.4 0.0 0.0038 17.0 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EEA23547.1 - 0.034 14.6 0.1 0.089 13.3 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair Amidohydro_2 PF04909.14 EEA23548.1 - 2.9e-34 119.2 0.0 7.2e-34 117.9 0.1 1.6 2 0 0 2 2 2 1 Amidohydrolase TatD_DNase PF01026.21 EEA23548.1 - 0.095 12.1 0.0 0.29 10.5 0.0 1.8 2 0 0 2 2 2 0 TatD related DNase FAA_hydrolase PF01557.18 EEA23550.1 - 2e-58 197.6 0.0 2.5e-58 197.3 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family GspH PF12019.8 EEA23550.1 - 0.14 12.6 0.1 0.29 11.6 0.1 1.6 1 1 0 1 1 1 0 Type II transport protein GspH Glyoxalase PF00903.25 EEA23551.1 - 2.5e-07 31.0 4.6 1.4e-06 28.6 2.5 2.5 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FAD_binding_3 PF01494.19 EEA23552.1 - 1.1e-37 130.2 0.0 2.9e-21 76.1 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 EEA23552.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EEA23552.1 - 0.064 12.5 0.0 1.7 7.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA23552.1 - 0.15 11.1 0.0 2.4 7.1 0.1 2.3 3 0 0 3 3 3 0 Lycopene cyclase protein Chromate_transp PF02417.15 EEA23553.1 - 3.2e-59 199.6 36.3 3.6e-31 108.4 14.6 2.4 3 0 0 3 3 3 2 Chromate transporter CcmH PF03918.14 EEA23553.1 - 0.31 10.3 1.1 1 8.7 0.0 2.3 2 0 0 2 2 2 0 Cytochrome C biogenesis protein Podoplanin PF05808.11 EEA23553.1 - 0.72 9.9 4.5 0.61 10.2 0.4 2.4 1 1 1 2 2 2 0 Podoplanin Tubulin PF00091.25 EEA23554.1 - 4.9e-65 219.4 0.0 6.6e-65 219.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EEA23554.1 - 3.2e-45 153.3 0.0 5e-45 152.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EEA23554.1 - 0.0022 17.7 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Mito_carr PF00153.27 EEA23555.1 - 2.6e-64 213.2 1.1 2.2e-20 72.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 EEA23555.1 - 0.078 13.2 0.0 5.2 7.3 0.0 2.5 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase PAE PF03283.13 EEA23555.1 - 0.2 10.7 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Pectinacetylesterase Antimicrobial19 PF08225.11 EEA23556.1 - 0.074 12.7 0.2 0.34 10.5 0.0 2.0 2 0 0 2 2 2 0 Pseudin antimicrobial peptide Amidase PF01425.21 EEA23557.1 - 7.6e-87 292.1 0.0 7.1e-86 288.9 0.0 1.9 1 1 0 1 1 1 1 Amidase Transp_cyt_pur PF02133.15 EEA23558.1 - 3.5e-12 45.8 5.7 4.3e-12 45.5 5.7 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.15 EEA23559.1 - 3e-56 191.1 26.8 3.5e-56 190.9 26.8 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1479 PF07350.12 EEA23560.1 - 4.1e-128 427.7 0.0 4.8e-128 427.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) GIT_CC PF16559.5 EEA23560.1 - 0.2 11.6 0.1 1.2 9.1 0.0 2.0 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Fungal_trans PF04082.18 EEA23561.1 - 6.6e-23 81.1 2.7 9.4e-23 80.6 2.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain TauD PF02668.16 EEA23562.1 - 3e-46 158.4 0.3 4.3e-46 157.9 0.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EEA23562.1 - 1.8e-05 25.3 0.8 4.4e-05 24.0 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 EEA23562.1 - 0.00034 19.8 0.0 0.0071 15.5 0.0 2.8 1 1 1 2 2 2 1 CsiD Glutaredoxin PF00462.24 EEA23563.1 - 3.1e-18 65.7 0.0 1e-16 60.9 0.0 2.7 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin PF00085.20 EEA23563.1 - 6.8e-13 48.5 0.0 1.8e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EEA23563.1 - 0.0081 16.5 0.0 2.7 8.4 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like RNase_T PF00929.24 EEA23564.1 - 6.6e-12 46.3 0.0 2.4e-11 44.5 0.0 1.9 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EEA23564.1 - 0.001 18.8 0.0 0.0044 16.8 0.0 1.9 1 1 0 1 1 1 1 3'-5' exonuclease FapA PF03961.13 EEA23565.1 - 0.04 12.5 0.4 0.074 11.6 0.4 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Cnn_1N PF07989.11 EEA23565.1 - 0.051 13.7 4.0 0.8 9.9 0.1 3.2 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 CCDC92 PF14916.6 EEA23565.1 - 0.11 12.3 1.9 12 5.8 0.0 2.6 2 0 0 2 2 2 0 Coiled-coil domain of unknown function Yippee-Mis18 PF03226.14 EEA23565.1 - 0.17 12.1 1.4 0.35 11.1 1.4 1.5 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2703 PF10865.8 EEA23565.1 - 0.3 11.3 1.8 9 6.5 0.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2703) DUF2757 PF10955.8 EEA23565.1 - 0.53 10.6 0.0 0.53 10.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) TSC22 PF01166.18 EEA23565.1 - 0.67 10.3 6.3 16 5.9 3.0 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family SlyX PF04102.12 EEA23565.1 - 4.6 7.9 6.1 6.1 7.5 0.1 3.4 3 0 0 3 3 3 0 SlyX DivIC PF04977.15 EEA23565.1 - 6.4 6.6 6.0 2 8.3 0.2 2.6 3 0 0 3 3 3 0 Septum formation initiator Beta_elim_lyase PF01212.21 EEA23566.1 - 2.6e-70 237.0 0.0 3.1e-70 236.8 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EEA23566.1 - 0.056 12.6 0.0 0.079 12.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA23566.1 - 0.085 11.4 0.0 0.23 10.0 0.0 1.5 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Pkinase PF00069.25 EEA23567.1 - 8.4e-69 231.9 0.0 2.1e-68 230.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23567.1 - 9e-34 116.9 0.0 1.7e-33 116.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EEA23567.1 - 6.7e-10 39.2 0.1 5.5e-09 36.3 0.1 2.3 2 0 0 2 2 2 1 FHA domain APH PF01636.23 EEA23567.1 - 0.0002 21.3 2.5 0.9 9.4 0.0 3.6 3 1 1 4 4 4 2 Phosphotransferase enzyme family Yop-YscD_cpl PF16697.5 EEA23567.1 - 0.0003 21.0 0.2 0.0034 17.7 0.0 2.5 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 EEA23567.1 - 0.0056 16.0 0.4 0.0097 15.3 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA23567.1 - 0.012 15.0 0.0 0.033 13.5 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EEA23567.1 - 0.047 12.5 0.0 0.12 11.2 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase RIO1 PF01163.22 EEA23567.1 - 0.11 12.1 0.2 0.18 11.4 0.2 1.3 1 0 0 1 1 1 0 RIO1 family MFS_1 PF07690.16 EEA23568.1 - 7.6e-45 153.4 42.2 7.6e-45 153.4 42.2 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23568.1 - 7.9e-11 41.5 30.0 2e-10 40.2 8.8 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_4 PF06779.14 EEA23568.1 - 0.00039 19.8 25.3 0.0013 18.1 10.5 2.5 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EEA23568.1 - 0.0016 17.3 0.2 0.0016 17.3 0.2 3.9 2 1 1 4 4 4 2 MFS_1 like family RNA_replicase_B PF03431.13 EEA23568.1 - 0.094 11.2 0.1 0.13 10.7 0.1 1.1 1 0 0 1 1 1 0 RNA replicase, beta-chain OATP PF03137.20 EEA23568.1 - 0.13 10.5 16.7 2 6.6 0.4 3.4 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Mobilization_B PF17511.2 EEA23568.1 - 5.4 7.4 9.5 0.66 10.3 0.8 2.6 2 0 0 2 2 2 0 Mobilization protein B FSH1 PF03959.13 EEA23569.1 - 1.9e-26 93.1 0.0 6.5e-26 91.3 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EEA23569.1 - 0.05 14.2 0.2 0.068 13.8 0.2 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EEA23569.1 - 0.086 12.6 0.0 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase ketoacyl-synt PF00109.26 EEA23570.1 - 5.1e-72 242.5 0.2 2.8e-71 240.1 0.1 2.3 3 0 0 3 3 2 1 Beta-ketoacyl synthase, N-terminal domain HTH_51 PF18558.1 EEA23570.1 - 4e-36 122.8 0.0 1.2e-35 121.3 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain Ketoacyl-synt_C PF02801.22 EEA23570.1 - 1.7e-29 102.2 0.0 4.7e-29 100.8 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EEA23570.1 - 3.6e-25 88.6 0.0 1.2e-24 86.9 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein Acyl_transf_1 PF00698.21 EEA23570.1 - 8.6e-23 81.3 0.0 1.6e-21 77.2 0.0 2.4 2 0 0 2 2 2 1 Acyl transferase domain SAT PF16073.5 EEA23570.1 - 6.1e-15 55.6 0.3 3.4e-10 40.1 0.2 3.6 3 0 0 3 3 3 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_12 PF08242.12 EEA23570.1 - 1.2e-12 48.4 0.0 3.2e-12 47.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EEA23570.1 - 1.9e-10 40.9 0.4 8.4e-10 38.9 0.2 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site Epimerase PF01370.21 EEA23570.1 - 6.9e-09 35.5 0.0 1.5e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 EEA23570.1 - 3.3e-08 34.1 0.0 9.4e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EEA23570.1 - 4.2e-07 30.4 0.0 1.1e-06 29.1 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EEA23570.1 - 1.2e-06 28.1 1.7 4.6e-06 26.2 0.1 2.5 3 0 0 3 3 2 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 EEA23570.1 - 6.5e-06 26.7 0.0 1.7e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PS-DH PF14765.6 EEA23570.1 - 1.4e-05 24.5 0.0 3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_23 PF13489.6 EEA23570.1 - 2.4e-05 24.2 0.0 5.8e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain KR PF08659.10 EEA23570.1 - 0.00062 19.7 0.2 0.0059 16.5 0.0 2.5 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EEA23570.1 - 0.0017 17.6 0.1 0.01 15.0 0.0 2.3 3 0 0 3 3 3 1 Polysaccharide biosynthesis protein Methyltransf_31 PF13847.6 EEA23570.1 - 0.0017 18.2 0.0 0.0037 17.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain K_oxygenase PF13434.6 EEA23570.1 - 0.065 12.4 0.1 0.55 9.3 0.1 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) DciA PF05258.12 EEA23570.1 - 0.15 12.5 0.0 0.77 10.2 0.0 2.3 2 0 0 2 2 1 0 Dna[CI] antecedent, DciA RmlD_sub_bind PF04321.17 EEA23570.1 - 0.17 10.9 0.0 12 4.9 0.0 2.4 2 0 0 2 2 2 0 RmlD substrate binding domain Ubie_methyltran PF01209.18 EEA23570.1 - 0.18 11.1 0.0 0.44 9.8 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Transferase PF02458.15 EEA23571.1 - 8.4e-19 67.5 0.0 1.5e-18 66.7 0.0 1.3 2 0 0 2 2 2 1 Transferase family PapA_C PF16911.5 EEA23572.1 - 0.00085 19.4 0.1 0.71 10.0 0.0 2.7 3 0 0 3 3 3 2 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus Neocarzinostat PF00960.18 EEA23572.1 - 0.22 11.5 1.9 0.44 10.6 1.9 1.4 1 0 0 1 1 1 0 Neocarzinostatin family ADH_zinc_N PF00107.26 EEA23573.1 - 2.3e-08 34.1 0.0 4.2e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA23573.1 - 2.4e-08 33.8 0.1 1.7e-07 31.1 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EEA23573.1 - 0.023 14.6 0.1 0.049 13.5 0.1 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Tri3 PF07428.11 EEA23574.1 - 8.6e-05 21.6 0.0 0.00033 19.7 0.0 1.8 2 0 0 2 2 2 1 15-O-acetyltransferase Tri3 ketoacyl-synt PF00109.26 EEA23575.1 - 4.6e-73 245.9 0.1 1e-72 244.8 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EEA23575.1 - 1.2e-33 115.7 0.2 4.9e-33 113.6 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EEA23575.1 - 2.7e-21 76.1 0.0 5.8e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EEA23575.1 - 3.1e-20 72.9 0.0 9.1e-19 68.1 0.0 2.2 2 0 0 2 2 2 1 Acyl transferase domain SAT PF16073.5 EEA23575.1 - 1e-14 54.9 3.3 3.1e-13 50.0 0.1 3.5 3 1 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis PP-binding PF00550.25 EEA23575.1 - 1.1e-13 51.3 3.0 7.6e-08 32.6 0.5 2.9 3 0 0 3 3 3 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EEA23575.1 - 1.7e-09 38.1 0.0 4.6e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EEA23575.1 - 4.7e-05 22.9 0.1 0.00012 21.6 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Epimerase PF01370.21 EEA23576.1 - 5.2e-23 81.8 0.0 7e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA23576.1 - 1e-10 41.3 0.0 1.6e-09 37.3 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EEA23576.1 - 1.5e-10 40.5 0.0 2.1e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA23576.1 - 1.6e-10 40.9 0.0 2.5e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EEA23576.1 - 3.2e-06 27.2 0.0 2.5e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 EEA23576.1 - 9e-06 25.3 0.0 1.5e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA23576.1 - 1e-05 25.5 0.0 1.8e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA23576.1 - 3.1e-05 23.3 0.0 4.5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short_C2 PF13561.6 EEA23576.1 - 0.0015 18.1 0.0 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 EEA23576.1 - 0.081 12.5 0.0 0.49 9.9 0.0 1.9 2 0 0 2 2 2 0 NmrA-like family Abhydrolase_6 PF12697.7 EEA23577.1 - 1.5e-09 38.8 0.0 2.1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA23577.1 - 0.00049 19.4 0.0 0.00075 18.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 adh_short PF00106.25 EEA23578.1 - 4.5e-09 36.0 0.0 8.3e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA23578.1 - 1.5e-06 28.3 0.0 2.2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EEA23578.1 - 3.8e-05 23.4 0.0 6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase OrsD PF12013.8 EEA23579.1 - 5.6e-11 42.9 0.7 1.1e-10 42.0 0.1 1.8 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D Fungal_trans_2 PF11951.8 EEA23579.1 - 7e-06 25.1 1.4 1.1e-05 24.5 1.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EEA23581.1 - 2.2e-32 112.4 23.5 2.2e-32 112.4 23.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23581.1 - 2.4e-09 36.6 20.5 4e-09 35.9 10.1 2.5 2 1 0 3 3 3 2 Sugar (and other) transporter PTR2 PF00854.21 EEA23581.1 - 0.0011 17.9 4.9 0.0019 17.1 4.9 1.5 1 0 0 1 1 1 1 POT family Borrelia_P13 PF05628.12 EEA23581.1 - 0.17 11.8 1.8 0.35 10.8 0.1 2.3 2 1 0 2 2 2 0 Borrelia membrane protein P13 GMC_oxred_N PF00732.19 EEA23582.1 - 5.6e-61 206.5 0.0 7.5e-61 206.1 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA23582.1 - 3.2e-36 125.0 0.0 5.6e-36 124.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EEA23582.1 - 0.00037 19.7 0.2 0.00065 18.9 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EEA23582.1 - 0.00065 19.4 0.0 0.094 12.3 0.1 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EEA23582.1 - 0.00069 18.9 0.4 0.0014 17.9 0.1 1.6 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EEA23582.1 - 0.0046 17.2 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA23582.1 - 0.028 13.7 0.0 0.34 10.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EEA23582.1 - 0.054 12.3 0.1 0.086 11.7 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_2 PF00890.24 EEA23582.1 - 0.081 12.0 0.0 5.8 5.9 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain p450 PF00067.22 EEA23583.1 - 4.5e-07 29.0 0.0 9e-07 28.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 EEA23584.1 - 0.00014 21.4 0.0 0.017 14.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Chitin_bind_1 PF00187.19 EEA23585.1 - 1.1e-11 45.0 86.4 6.2e-06 26.6 21.9 3.9 4 0 0 4 4 4 3 Chitin recognition protein LysM PF01476.20 EEA23585.1 - 0.2 11.8 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 LysM domain RVT_2 PF07727.14 EEA23588.1 - 4.8e-11 42.8 0.0 8.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA23588.1 - 7.5e-08 32.6 0.1 3.2e-06 27.3 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EEA23588.1 - 0.00044 20.0 0.2 0.00044 20.0 0.2 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA23588.1 - 0.14 12.4 0.0 0.53 10.5 0.0 2.0 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Arteri_Gl PF00951.18 EEA23588.1 - 0.16 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein DUF3517 PF12030.8 EEA23588.1 - 0.17 10.8 0.0 0.39 9.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3517) Integrase_H2C2 PF17921.1 EEA23588.1 - 0.29 11.3 4.8 0.28 11.3 0.1 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain CPT PF07931.12 EEA23589.1 - 0.073 12.9 0.0 0.082 12.7 0.0 1.1 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein peroxidase PF00141.23 EEA23590.1 - 1.2e-86 290.2 0.0 2.6e-46 158.2 0.0 2.2 2 0 0 2 2 2 2 Peroxidase GST_C_3 PF14497.6 EEA23590.1 - 0.047 13.9 0.0 16 5.7 0.0 2.5 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain p450 PF00067.22 EEA23592.1 - 1.1e-81 274.9 0.0 1.4e-81 274.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EEA23593.1 - 1.2e-36 126.4 56.5 1.2e-36 126.4 56.5 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA23593.1 - 7e-14 51.2 15.0 7e-14 51.2 15.0 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Aldo_ket_red PF00248.21 EEA23594.1 - 5.2e-41 140.8 0.0 5.9e-41 140.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family FSH1 PF03959.13 EEA23595.1 - 1.1e-30 106.9 0.0 1.5e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EEA23595.1 - 0.016 15.0 0.0 0.35 10.6 0.0 2.2 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Fungal_trans PF04082.18 EEA23596.1 - 5.5e-13 48.6 0.3 3e-12 46.1 0.0 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain HrpB7 PF09486.10 EEA23596.1 - 0.06 13.7 4.0 1 9.8 0.5 2.3 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Fungal_trans PF04082.18 EEA23597.1 - 3.6e-13 49.2 0.3 2.3e-12 46.5 0.0 2.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain HrpB7 PF09486.10 EEA23597.1 - 0.037 14.4 3.9 0.8 10.1 0.5 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) P16-Arc PF04699.14 EEA23597.1 - 0.25 11.8 1.0 0.68 10.4 0.2 2.0 2 1 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) ADH_N PF08240.12 EEA23598.1 - 4.7e-10 39.3 0.0 8.9e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA23598.1 - 4.6e-08 33.1 0.0 7.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Fas_alpha_ACP PF18325.1 EEA23599.1 - 6.1e-57 192.5 0.0 2e-56 190.8 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 EEA23599.1 - 8e-33 113.8 0.0 1.6e-32 112.8 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 EEA23599.1 - 1.2e-21 77.5 0.0 2.5e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EEA23599.1 - 1.9e-19 69.8 0.4 6.9e-19 68.0 0.1 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EEA23599.1 - 0.0023 17.4 0.0 0.0059 16.1 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA23599.1 - 0.075 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 KR domain adh_short_C2 PF13561.6 EEA23599.1 - 0.093 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase DUF1729 PF08354.10 EEA23600.1 - 2.4e-150 500.3 0.0 4.5e-150 499.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EEA23600.1 - 2e-53 182.0 0.0 4.5e-53 180.8 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 EEA23600.1 - 1.9e-30 106.4 0.0 4.4e-30 105.2 0.0 1.7 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_meander PF17951.1 EEA23600.1 - 5.5e-23 81.4 0.0 1.2e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 EEA23600.1 - 1.4e-21 76.4 0.0 3e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EEA23600.1 - 1.5e-08 34.9 0.0 4.1e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 EEA23600.1 - 0.00052 20.0 1.2 0.0012 18.8 1.2 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta NMO PF03060.15 EEA23600.1 - 0.0007 19.1 0.1 0.0059 16.0 0.1 2.2 1 1 0 1 1 1 1 Nitronate monooxygenase Fungal_trans PF04082.18 EEA23601.1 - 1.5e-16 60.2 1.8 1.9e-16 59.9 0.3 1.8 1 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23601.1 - 6.8e-09 35.7 8.2 1.3e-08 34.8 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Av_adeno_fibre PF06536.11 EEA23601.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Avian adenovirus fibre, N-terminal FAS_I_H PF18314.1 EEA23601.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 EEA23602.1 - 7.8e-73 245.2 0.0 1.8e-72 244.0 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain HTH_51 PF18558.1 EEA23602.1 - 8.2e-34 115.4 0.0 2.3e-33 113.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain Ketoacyl-synt_C PF02801.22 EEA23602.1 - 2.9e-30 104.7 0.5 7.6e-30 103.4 0.1 2.0 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 EEA23602.1 - 2.6e-29 102.7 1.3 8.2e-29 101.1 0.9 1.9 2 0 0 2 2 2 1 Acyl transferase domain NAD_binding_4 PF07993.12 EEA23602.1 - 6.1e-23 81.3 0.0 1.4e-22 80.1 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EEA23602.1 - 6.5e-23 80.9 6.6 5e-12 46.0 0.2 3.2 3 0 0 3 3 3 2 Phosphopantetheine attachment site SAT PF16073.5 EEA23602.1 - 2.7e-16 60.0 4.6 1.4e-14 54.4 0.1 3.7 3 1 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_12 PF08242.12 EEA23602.1 - 1.1e-14 54.9 0.0 3e-14 53.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PS-DH PF14765.6 EEA23602.1 - 2.9e-10 39.9 0.0 5.1e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_25 PF13649.6 EEA23602.1 - 2.6e-08 34.5 0.0 7.1e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA23602.1 - 1e-07 32.5 0.0 3e-07 31.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 EEA23602.1 - 1.2e-07 31.4 0.6 2e-06 27.4 0.1 2.9 3 0 0 3 3 3 1 Thiolase, N-terminal domain Methyltransf_23 PF13489.6 EEA23602.1 - 2e-07 31.0 0.0 7.2e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Epimerase PF01370.21 EEA23602.1 - 2.3e-06 27.3 0.0 4.1e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_31 PF13847.6 EEA23602.1 - 4.7e-06 26.5 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EEA23602.1 - 0.0014 19.1 0.0 0.0035 17.8 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Polysacc_synt_2 PF02719.15 EEA23602.1 - 0.023 13.8 0.0 0.1 11.7 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein ACP_syn_III PF08545.10 EEA23602.1 - 0.079 12.8 2.1 2 8.3 0.3 3.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Semialdhyde_dh PF01118.24 EEA23602.1 - 0.1 13.0 0.0 0.3 11.5 0.0 1.8 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CENP-B_dimeris PF09026.10 EEA23602.1 - 0.37 11.2 5.1 0.83 10.1 5.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain adh_short PF00106.25 EEA23603.1 - 2.8e-40 137.9 0.0 3.5e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23603.1 - 6.9e-35 120.7 0.0 8.9e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23603.1 - 7.1e-11 42.3 0.0 9.6e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA23603.1 - 0.013 15.0 0.0 0.17 11.3 0.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EEA23603.1 - 0.018 14.5 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Transferase PF02458.15 EEA23604.1 - 1.2e-24 86.7 0.0 1.7e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Transferase family DUF711 PF05167.12 EEA23604.1 - 0.1 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) FAD_binding_3 PF01494.19 EEA23605.1 - 8e-21 74.7 0.2 6.1e-10 38.9 0.0 2.4 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 EEA23605.1 - 9.5e-05 22.1 1.1 0.00083 19.0 0.7 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA23605.1 - 0.0001 21.7 0.1 0.03 13.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA23605.1 - 0.00011 22.4 0.0 0.00035 20.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA23605.1 - 0.0019 18.2 0.0 0.0054 16.7 0.0 1.8 1 1 0 1 1 1 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EEA23605.1 - 0.0051 15.7 0.1 0.46 9.3 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 EEA23605.1 - 0.0065 17.0 0.0 0.026 15.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA23605.1 - 0.017 14.2 0.1 0.077 12.1 0.1 2.0 1 1 0 1 1 1 0 FAD binding domain SE PF08491.10 EEA23605.1 - 0.091 11.8 0.0 5.5 6.0 0.0 2.2 2 0 0 2 2 2 0 Squalene epoxidase Pyr_redox_3 PF13738.6 EEA23605.1 - 0.12 11.6 0.2 0.58 9.4 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA23605.1 - 0.15 11.1 0.0 3.3 6.7 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_4 PF01565.23 EEA23606.1 - 2.6e-26 92.0 5.4 4.4e-26 91.3 5.4 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA23606.1 - 3.5e-10 39.8 0.1 6.4e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 EEA23608.1 - 8.5e-29 100.1 0.1 1.7e-28 99.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Rap1_C PF11626.8 EEA23608.1 - 0.0019 18.2 0.0 0.1 12.7 0.0 2.7 2 1 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BBE PF08031.12 EEA23608.1 - 0.0074 16.4 0.1 0.02 15.0 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like zf-C2HCIx2C PF10782.9 EEA23608.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger FAD_binding_4 PF01565.23 EEA23609.1 - 5.9e-29 100.6 0.1 1.2e-28 99.6 0.1 1.5 2 0 0 2 2 2 1 FAD binding domain zf-C2HCIx2C PF10782.9 EEA23609.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger Acetyltransf_1 PF00583.25 EEA23610.1 - 7.5e-14 52.0 0.0 9.4e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA23610.1 - 1.3e-11 44.5 0.0 1.7e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA23610.1 - 8.6e-10 38.9 0.0 1.3e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA23610.1 - 2.8e-06 27.2 0.0 4.5e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EEA23610.1 - 0.0012 18.9 0.2 0.0034 17.4 0.2 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA23610.1 - 0.0057 16.8 0.0 0.0093 16.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EEA23610.1 - 0.014 15.5 0.0 0.016 15.3 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF2156 PF09924.9 EEA23610.1 - 0.028 13.4 0.0 0.029 13.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) Acetyltransf_3 PF13302.7 EEA23610.1 - 0.045 14.4 0.0 0.051 14.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 EEA23610.1 - 0.046 13.4 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ DUF16 PF01519.16 EEA23611.1 - 9.1e-05 22.9 1.8 9.1e-05 22.9 1.8 2.3 2 1 0 2 2 2 1 Protein of unknown function DUF16 T2SSL PF05134.13 EEA23611.1 - 0.02 14.2 0.3 0.041 13.2 0.3 1.7 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein L MetOD2 PF18548.1 EEA23611.1 - 0.026 14.6 4.1 0.11 12.7 1.6 2.5 2 0 0 2 2 2 0 Metanogen output domain 2 RHD_dimer PF16179.5 EEA23611.1 - 0.041 13.9 1.9 0.058 13.4 0.2 1.9 2 0 0 2 2 2 0 Rel homology dimerisation domain SlyX PF04102.12 EEA23611.1 - 6.2 7.5 7.6 0.52 11.0 0.5 2.6 3 0 0 3 3 3 0 SlyX F-box-like PF12937.7 EEA23612.1 - 0.099 12.6 6.0 1.6 8.7 4.8 3.0 2 1 0 2 2 2 0 F-box-like Alginate_lyase2 PF08787.11 EEA23613.1 - 1.4e-36 126.6 0.1 1.7e-36 126.3 0.1 1.0 1 0 0 1 1 1 1 Alginate lyase p450 PF00067.22 EEA23614.1 - 2.9e-67 227.4 0.0 3.7e-67 227.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRRNT_2 PF08263.12 EEA23614.1 - 0.19 12.1 0.1 0.45 10.9 0.1 1.7 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain Isochorismatase PF00857.20 EEA23615.1 - 6.8e-25 88.2 0.0 9e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family Fungal_trans PF04082.18 EEA23616.1 - 6.8e-10 38.4 0.0 1.1e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HgmA PF04209.13 EEA23617.1 - 1.7e-144 481.7 0.1 1.9e-144 481.5 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Transp_cyt_pur PF02133.15 EEA23618.1 - 1.5e-27 96.5 25.7 3.6e-26 91.9 25.7 2.1 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2106 PF09879.9 EEA23618.1 - 0.018 14.5 0.1 0.061 12.9 0.1 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) Isochorismatase PF00857.20 EEA23619.1 - 7.5e-30 104.4 0.0 8.9e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family MFS_1 PF07690.16 EEA23620.1 - 1.1e-50 172.5 45.5 4.2e-44 150.9 36.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23620.1 - 1.7e-10 40.4 12.9 1.7e-10 40.4 12.9 2.5 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EEA23620.1 - 1e-08 34.1 19.5 2.8e-08 32.7 19.4 1.8 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Abhydrolase_3 PF07859.13 EEA23621.1 - 2.8e-57 194.0 0.1 4.7e-57 193.2 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA23621.1 - 5.3e-06 27.2 1.1 8.4e-06 26.5 1.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EEA23621.1 - 9.3e-06 25.3 0.0 3.1e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EEA23621.1 - 1e-05 24.6 1.1 3.3e-05 23.0 1.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EEA23621.1 - 0.071 12.0 0.0 0.094 11.6 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase Toxin_22 PF08092.11 EEA23621.1 - 0.44 10.6 2.0 1.1 9.4 0.1 2.4 2 0 0 2 2 2 0 Magi peptide toxin family Ank_2 PF12796.7 EEA23622.1 - 2.2e-21 76.2 0.2 8.4e-12 45.5 0.0 4.1 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA23622.1 - 3.8e-19 68.5 4.4 4.9e-12 45.8 0.1 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA23622.1 - 7.5e-19 67.3 1.3 3.2e-05 24.2 0.1 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EEA23622.1 - 1.9e-16 60.2 1.1 5.4e-05 23.7 0.1 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA23622.1 - 3e-15 54.8 4.4 0.0008 19.7 0.1 5.5 6 0 0 6 6 6 3 Ankyrin repeat Epimerase PF01370.21 EEA23623.1 - 1.1e-16 61.0 0.1 2.2e-16 60.1 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EEA23623.1 - 2.2e-09 37.3 0.5 5.6e-09 35.9 0.4 1.7 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 EEA23623.1 - 2.8e-09 36.4 0.6 5.5e-09 35.4 0.6 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EEA23623.1 - 6.4e-08 32.7 0.2 1.2e-07 31.9 0.2 1.5 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EEA23623.1 - 2.9e-07 30.2 0.3 7e-07 29.0 0.3 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EEA23623.1 - 8.9e-06 25.0 0.2 9.3e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 EEA23623.1 - 0.0064 15.7 0.2 0.0098 15.1 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA23623.1 - 0.018 14.1 0.9 0.058 12.5 0.9 1.7 1 1 0 1 1 1 0 RmlD substrate binding domain Cellulase PF00150.18 EEA23624.1 - 3.5e-46 157.9 3.6 5.2e-46 157.3 3.6 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 EEA23624.1 - 1.8e-11 43.8 18.6 1.8e-11 43.8 18.6 2.7 2 0 0 2 2 2 1 Fungal cellulose binding domain Toxin_7 PF05980.12 EEA23624.1 - 0.026 14.8 0.6 0.05 13.8 0.6 1.4 1 0 0 1 1 1 0 Toxin 7 MFS_1 PF07690.16 EEA23625.1 - 3.9e-35 121.4 22.8 3.9e-35 121.4 22.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily UPF0060 PF02694.15 EEA23625.1 - 0.057 13.7 1.1 0.057 13.7 1.1 2.8 4 0 0 4 4 4 0 Uncharacterised BCR, YnfA/UPF0060 family Phage_holin_5_2 PF16079.5 EEA23625.1 - 0.58 10.5 9.3 0.17 12.3 0.5 3.7 3 1 1 4 4 4 0 Phage holin family Hol44, in holin superfamily V zf-C2H2_2 PF12756.7 EEA23626.1 - 1.2e-26 93.0 1.5 3e-26 91.7 1.5 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EEA23626.1 - 0.28 12.1 2.5 2.6 9.1 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Methyltransf_23 PF13489.6 EEA23627.1 - 2e-21 76.5 0.0 3.1e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA23627.1 - 2.8e-15 56.8 0.0 8.6e-15 55.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA23627.1 - 4.3e-14 52.9 0.0 9.3e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA23627.1 - 1.6e-12 47.5 0.0 5.6e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EEA23627.1 - 6e-09 36.5 0.0 3.9e-08 33.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA23627.1 - 8.5e-08 31.8 0.0 1.8e-06 27.5 0.0 2.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EEA23627.1 - 1.2e-05 25.5 0.0 2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EEA23627.1 - 6.7e-05 22.5 0.0 0.0016 18.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EEA23627.1 - 6.7e-05 22.3 0.0 0.0019 17.5 0.0 2.1 2 0 0 2 2 2 1 O-methyltransferase domain PrmA PF06325.13 EEA23627.1 - 0.00047 19.7 0.0 0.00072 19.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EEA23627.1 - 0.0028 17.1 0.0 0.021 14.3 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.15 EEA23627.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase CMAS PF02353.20 EEA23627.1 - 0.025 13.9 0.0 0.073 12.3 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EEA23627.1 - 0.044 13.5 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase UPF0146 PF03686.13 EEA23627.1 - 0.052 13.4 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0146) p450 PF00067.22 EEA23628.1 - 3.3e-55 187.7 0.0 4.4e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 dCMP_cyt_deam_1 PF00383.23 EEA23629.1 - 5.9e-08 32.5 0.0 9.1e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA23629.1 - 4.7e-06 26.4 0.0 6.7e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Glyco_hydro_16 PF00722.21 EEA23630.1 - 7.6e-17 61.3 0.8 1.5e-16 60.4 0.8 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_trans_2_3 PF13632.6 EEA23631.1 - 2e-54 184.5 0.9 2e-54 184.5 0.9 2.5 2 1 1 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EEA23631.1 - 0.0019 18.0 0.0 0.0089 15.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glycophorin_A PF01102.18 EEA23631.1 - 0.073 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Glycophorin A peroxidase PF00141.23 EEA23632.1 - 3e-21 76.2 0.0 4.9e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 Peroxidase PSI_PSAK PF01241.18 EEA23632.1 - 0.0072 16.3 0.1 0.02 14.9 0.1 1.8 1 1 0 1 1 1 1 Photosystem I psaG / psaK GST_C_2 PF13410.6 EEA23632.1 - 0.085 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain WSC PF01822.19 EEA23633.1 - 1.2e-61 204.8 62.4 6.8e-18 64.6 10.0 4.5 4 0 0 4 4 4 4 WSC domain Glyoxal_oxid_N PF07250.11 EEA23633.1 - 6.1e-25 87.8 0.0 6.3e-24 84.5 0.0 2.3 2 0 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EEA23633.1 - 1.1e-18 67.3 0.0 3.8e-18 65.6 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.6 EEA23633.1 - 0.028 14.7 0.8 2.9 8.3 0.0 4.1 4 0 0 4 4 4 0 Kelch motif Metallophos PF00149.28 EEA23634.1 - 2.8e-19 70.4 2.4 2.8e-19 70.4 2.4 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EEA23634.1 - 7.5e-19 68.4 0.1 1.8e-18 67.1 0.1 1.7 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EEA23634.1 - 2.5e-14 53.6 2.0 3.8e-14 53.0 1.2 1.8 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain RVT_2 PF07727.14 EEA23635.1 - 2.7e-40 138.5 0.0 4.5e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA23635.1 - 4.5e-08 32.8 0.1 1.3e-07 31.3 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA23635.1 - 3.7e-06 27.1 0.0 1e-05 25.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 EEA23635.1 - 0.00019 21.1 0.8 0.11 12.3 0.0 3.1 2 0 0 2 2 2 2 Integrase core domain DUF4160 PF13711.6 EEA23635.1 - 0.13 12.6 0.2 0.67 10.3 0.2 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) DUF3328 PF11807.8 EEA23636.1 - 0.0062 16.3 0.0 0.0079 16.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Patatin PF01734.22 EEA23637.1 - 2.4e-09 37.7 0.1 3.2e-09 37.3 0.1 1.1 1 0 0 1 1 1 1 Patatin-like phospholipase Patatin PF01734.22 EEA23638.1 - 0.021 15.0 0.1 0.033 14.4 0.1 1.3 1 0 0 1 1 1 0 Patatin-like phospholipase Baculo_PEP_C PF04513.12 EEA23639.1 - 0.018 15.1 7.2 0.54 10.3 0.6 3.9 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HCR PF07111.12 EEA23639.1 - 0.037 12.1 5.5 0.067 11.3 5.5 1.3 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) DUF4208 PF13907.6 EEA23639.1 - 0.15 12.5 3.1 0.81 10.2 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4208) CwsA PF10814.8 EEA23639.1 - 0.21 11.8 0.1 0.21 11.8 0.1 2.3 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA AAA_13 PF13166.6 EEA23639.1 - 3.8 6.0 11.2 3.6 6.1 4.3 2.2 2 0 0 2 2 2 0 AAA domain NPV_P10 PF05531.12 EEA23639.1 - 4.1 7.9 7.6 17 5.9 1.9 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Zn_clus PF00172.18 EEA23640.1 - 1.1e-09 38.3 7.4 2.5e-09 37.1 7.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA23641.1 - 3.5e-32 111.7 15.6 3.5e-32 111.7 15.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA23641.1 - 4.2e-15 55.6 3.3 4.2e-15 55.6 3.3 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter DUF1269 PF06897.12 EEA23641.1 - 0.17 12.2 1.5 5.4 7.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) Amidase PF01425.21 EEA23642.1 - 3.1e-93 313.2 0.0 8e-93 311.8 0.0 1.6 1 1 0 1 1 1 1 Amidase Reo_sigma1 PF01664.16 EEA23642.1 - 0.011 15.1 0.1 0.057 12.7 0.0 1.9 2 0 0 2 2 2 0 Reovirus viral attachment protein sigma 1 APH PF01636.23 EEA23645.1 - 4.3e-15 56.3 0.1 6.1e-15 55.8 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA23645.1 - 3.1e-09 36.7 0.0 3.7e-08 33.2 0.0 2.1 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EEA23645.1 - 0.024 14.0 0.0 3 7.2 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain DEAD PF00270.29 EEA23646.1 - 3.2e-14 53.1 0.1 7.3e-14 51.9 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA23646.1 - 2e-13 50.7 0.0 5e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA23646.1 - 4.4e-06 26.8 0.0 1.9e-05 24.7 0.0 2.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA23646.1 - 0.018 14.2 0.0 0.035 13.3 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CTU2 PF10288.9 EEA23646.1 - 0.082 13.2 1.8 0.94 9.7 0.1 2.8 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 AF-4 PF05110.13 EEA23646.1 - 0.32 9.0 18.0 0.43 8.6 18.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Hamartin PF04388.12 EEA23646.1 - 4 6.0 6.4 6.8 5.2 6.4 1.4 1 0 0 1 1 1 0 Hamartin protein OrsD PF12013.8 EEA23647.1 - 3.9e-12 46.6 12.4 4.2e-12 46.5 9.6 2.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D Helicase_C PF00271.31 EEA23647.1 - 8.2e-12 45.4 0.0 1e-10 41.9 0.0 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA23647.1 - 4.6e-11 42.8 0.0 1.7e-10 41.0 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA23647.1 - 0.00085 19.4 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EEA23647.1 - 0.016 15.9 0.1 0.058 14.1 0.1 2.0 1 0 0 1 1 1 0 RecQ zinc-binding zf-C2H2_12 PF18658.1 EEA23647.1 - 0.035 13.7 3.0 0.19 11.3 3.0 2.3 1 0 0 1 1 1 0 Zinc-finger C2H2-type Peptidase_S8 PF00082.22 EEA23647.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Subtilase family DEAD PF00270.29 EEA23648.1 - 4.4e-11 42.9 0.0 1.6e-10 41.0 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA23648.1 - 1.5e-08 34.9 0.1 2.2e-07 31.2 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OrsD PF12013.8 EEA23648.1 - 6e-05 23.5 6.9 7.3e-05 23.2 4.2 2.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 EEA23648.1 - 0.00082 19.4 0.0 0.0019 18.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EEA23648.1 - 0.016 15.9 0.1 0.056 14.2 0.1 2.0 1 0 0 1 1 1 0 RecQ zinc-binding Peptidase_S8 PF00082.22 EEA23648.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Subtilase family DEAD PF00270.29 EEA23649.1 - 2.6e-14 53.4 0.1 5.9e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA23649.1 - 2.7e-13 50.2 0.0 6e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA23649.1 - 1.9e-06 28.0 0.0 6.7e-06 26.2 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CTU2 PF10288.9 EEA23649.1 - 0.089 13.0 1.1 1.4 9.2 0.0 2.8 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 AF-4 PF05110.13 EEA23649.1 - 6.6 4.7 19.9 11 4.0 19.9 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CENP-B_dimeris PF09026.10 EEA23650.1 - 1.4 9.4 6.3 0.13 12.7 1.1 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain OrsD PF12013.8 EEA23651.1 - 2.4e-14 53.8 0.3 8e-14 52.1 0.1 2.0 1 1 1 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D APG6_N PF17675.1 EEA23653.1 - 0.0021 18.6 6.2 0.0026 18.3 6.2 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 EEA23653.1 - 0.0059 16.2 3.0 0.0059 16.2 3.0 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit ZapB PF06005.12 EEA23653.1 - 0.011 16.1 8.8 0.019 15.4 8.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB GAS PF13851.6 EEA23653.1 - 0.025 13.9 10.0 0.032 13.6 10.0 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_23 PF13476.6 EEA23653.1 - 0.032 14.7 5.0 0.036 14.5 5.0 1.2 1 0 0 1 1 1 0 AAA domain DUF5595 PF18077.1 EEA23653.1 - 0.053 13.6 0.8 0.053 13.6 0.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5595) Jnk-SapK_ap_N PF09744.9 EEA23653.1 - 0.075 13.2 9.3 0.11 12.8 9.3 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF1798 PF08807.10 EEA23653.1 - 0.09 12.9 3.8 0.14 12.3 3.5 1.5 1 1 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) NRBF2 PF08961.10 EEA23653.1 - 0.16 11.5 7.6 0.36 10.4 7.6 1.8 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator HALZ PF02183.18 EEA23653.1 - 0.37 11.0 14.3 0.25 11.6 2.2 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper YabA PF06156.13 EEA23653.1 - 0.38 11.4 6.4 0.63 10.7 6.4 1.4 1 0 0 1 1 1 0 Initiation control protein YabA Tho2 PF11262.8 EEA23653.1 - 1.1 8.4 6.3 1.5 7.9 6.3 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DivIC PF04977.15 EEA23653.1 - 5.4 6.9 11.7 17 5.3 11.7 1.8 1 1 0 1 1 1 0 Septum formation initiator Mrpl_C PF18502.1 EEA23655.1 - 0.014 15.6 2.1 0.021 15.1 1.0 1.7 1 1 1 2 2 2 0 54S ribosomal protein L8 C-terminal domain Helitron_like_N PF14214.6 EEA23655.1 - 0.13 12.4 0.2 0.18 12.0 0.2 1.1 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus Alk_phosphatase PF00245.20 EEA23656.1 - 4.3e-71 240.0 0.4 3.3e-70 237.1 0.4 2.0 1 1 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.23 EEA23656.1 - 2e-08 34.0 1.4 9.1e-07 28.6 1.3 2.6 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EEA23656.1 - 7.8e-05 22.4 0.4 0.00015 21.5 0.4 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EEA23656.1 - 0.00074 18.9 0.2 0.0019 17.6 0.1 1.7 2 0 0 2 2 2 1 Metalloenzyme superfamily DUF229 PF02995.17 EEA23656.1 - 0.011 14.4 0.1 0.017 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF1501 PF07394.12 EEA23656.1 - 0.062 12.4 0.2 0.094 11.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) GMC_oxred_N PF00732.19 EEA23657.1 - 3e-62 210.6 1.5 4.3e-62 210.1 1.5 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA23657.1 - 3.9e-29 102.0 0.0 6.4e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EEA23657.1 - 3.5e-05 23.9 0.8 9.9e-05 22.5 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA23657.1 - 0.0007 18.4 0.4 0.0054 15.5 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EEA23657.1 - 0.0016 19.0 0.2 0.0048 17.4 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA23657.1 - 0.0017 17.7 0.7 0.0091 15.3 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA23657.1 - 0.0017 17.7 0.1 0.0035 16.6 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EEA23657.1 - 0.0022 17.1 0.3 0.0034 16.5 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EEA23657.1 - 0.0066 16.1 0.5 0.0066 16.1 0.5 2.3 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA23657.1 - 0.0094 15.1 2.2 0.015 14.4 1.1 1.8 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 EEA23657.1 - 0.042 12.7 0.1 0.069 12.0 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase TrkA_N PF02254.18 EEA23657.1 - 0.049 13.9 0.2 0.1 12.9 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_9 PF13454.6 EEA23657.1 - 0.052 13.5 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding Mannitol_dh_C PF08125.13 EEA23658.1 - 1.2e-74 250.9 0.0 1.8e-74 250.4 0.0 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EEA23658.1 - 1.8e-45 154.8 0.0 3.3e-45 153.9 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain Abhydrolase_3 PF07859.13 EEA23659.1 - 1.6e-07 31.4 0.0 1.8e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA23659.1 - 0.0041 16.0 0.0 0.0051 15.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family FAD_binding_4 PF01565.23 EEA23660.1 - 2.2e-20 72.8 0.0 3.9e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA23660.1 - 3.2e-05 24.0 0.3 0.00069 19.7 0.0 2.7 2 0 0 2 2 2 1 Berberine and berberine like Sugar_tr PF00083.24 EEA23661.1 - 2.2e-73 247.7 18.8 2.6e-73 247.4 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23661.1 - 7.9e-27 94.1 21.9 1.1e-26 93.7 21.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily 7tm_1 PF00001.21 EEA23661.1 - 0.0017 17.7 0.0 0.0047 16.3 0.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TRI12 PF06609.13 EEA23661.1 - 0.018 13.5 3.9 0.016 13.7 0.7 2.0 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Glyco_hydro_2_C PF02836.17 EEA23663.1 - 7.3e-104 347.1 0.8 9.9e-104 346.7 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 EEA23663.1 - 6.2e-57 193.0 0.0 1.4e-56 191.9 0.0 1.5 2 0 0 2 2 2 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 EEA23663.1 - 7.1e-45 152.9 0.3 1.4e-44 152.0 0.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 EEA23663.1 - 1.4e-21 76.7 0.4 5e-21 75.0 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 EEA23663.1 - 1.5e-07 32.1 0.1 5e-06 27.2 0.0 2.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.14 EEA23663.1 - 0.039 13.2 0.4 0.28 10.4 0.1 2.4 2 1 1 3 3 3 0 Glucanosyltransferase REV1_C PF16727.5 EEA23664.1 - 0.18 12.2 3.8 4.7 7.7 0.3 2.4 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA23664.1 - 2.8 7.7 5.7 0.78 9.5 0.2 2.5 3 0 0 3 3 3 0 Sulfotransferase domain RVT_2 PF07727.14 EEA23665.1 - 2e-38 132.4 0.2 3.6e-38 131.6 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EEA23665.1 - 0.017 14.6 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Orthopox_F14 PF06076.12 EEA23665.1 - 0.057 13.7 2.8 0.15 12.3 2.8 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein Flg_hook PF02120.16 EEA23665.1 - 0.057 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Hydrolase PF00702.26 EEA23666.1 - 3.1e-07 30.9 0.0 6.5e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA23666.1 - 6.2e-06 26.4 0.0 7.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DAO PF01266.24 EEA23667.1 - 3.4e-43 148.6 0.0 4e-43 148.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA23667.1 - 0.0085 15.4 0.0 0.042 13.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA23667.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EEA23667.1 - 0.038 14.0 0.1 3.9 7.4 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EEA23667.1 - 0.095 12.9 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SLT PF01464.20 EEA23668.1 - 0.053 13.2 0.1 0.91 9.2 0.1 2.3 1 1 0 1 1 1 0 Transglycosylase SLT domain GST_C PF00043.25 EEA23669.1 - 4.4e-08 33.2 0.0 5.8e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA23669.1 - 7.2e-07 29.5 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA23669.1 - 1.2e-06 28.8 0.0 2.4e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA23669.1 - 1.7e-06 28.0 0.0 2.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA23669.1 - 1.3e-05 25.4 0.0 3.1e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA23669.1 - 6.6e-05 23.0 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Zn_clus PF00172.18 EEA23670.1 - 3e-07 30.4 5.0 5.4e-07 29.6 5.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_S29 PF02907.15 EEA23670.1 - 0.089 12.5 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Zn_clus PF00172.18 EEA23671.1 - 3e-07 30.4 5.0 5.4e-07 29.6 5.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_S29 PF02907.15 EEA23671.1 - 0.089 12.5 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease AAA_16 PF13191.6 EEA23672.1 - 2.5e-09 37.7 0.1 2.5e-09 37.7 0.1 3.5 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 EEA23672.1 - 1.7e-06 28.4 0.0 2e-05 24.9 0.0 2.9 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EEA23672.1 - 4.1e-05 23.6 0.1 0.00087 19.2 0.0 3.1 2 0 0 2 2 2 1 NACHT domain TPR_10 PF13374.6 EEA23672.1 - 6.2e-05 22.7 8.4 0.051 13.5 0.1 6.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA23672.1 - 0.00015 21.9 17.0 0.0064 16.8 0.1 7.5 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_3 PF07720.12 EEA23672.1 - 0.006 16.6 0.1 1.1 9.3 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat AAA PF00004.29 EEA23672.1 - 0.037 14.5 0.8 0.33 11.4 0.0 3.2 2 2 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) HR_lesion PF05514.11 EEA23672.1 - 0.19 11.9 0.8 1.1 9.5 0.3 2.3 2 0 0 2 2 2 0 HR-like lesion-inducing ComGF PF15980.5 EEA23672.1 - 0.69 10.3 4.9 0.36 11.2 0.1 3.0 3 0 0 3 3 3 0 Putative Competence protein ComGF adh_short PF00106.25 EEA23673.1 - 2.5e-22 79.3 0.4 5.8e-17 61.8 0.4 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23673.1 - 1.6e-14 54.1 0.4 4.2e-10 39.6 0.4 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23673.1 - 7.3e-12 45.6 0.5 1.1e-11 44.9 0.5 1.3 1 0 0 1 1 1 1 KR domain 2_5_RNA_ligase2 PF13563.6 EEA23673.1 - 0.025 14.5 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily Fungal_trans_2 PF11951.8 EEA23674.1 - 0.00059 18.8 2.3 0.0016 17.3 2.3 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Neisseria_TspB PF05616.13 EEA23675.1 - 5.8 5.3 9.9 6.8 5.0 9.9 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Ank_2 PF12796.7 EEA23676.1 - 1.3e-30 105.8 0.0 6.9e-13 49.0 0.0 3.0 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA23676.1 - 2.2e-20 72.8 0.2 4.9e-07 30.2 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA23676.1 - 4.1e-17 60.5 0.0 0.0028 18.0 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EEA23676.1 - 6.1e-17 61.5 2.1 0.00021 21.5 0.0 4.6 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA23676.1 - 1e-13 51.0 0.0 0.0025 18.2 0.1 4.7 4 0 0 4 4 4 4 Ankyrin repeat p450 PF00067.22 EEA23677.1 - 9.9e-38 130.1 0.0 1.4e-37 129.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3437 PF11919.8 EEA23677.1 - 0.09 12.7 1.1 0.39 10.7 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) F-box-like PF12937.7 EEA23678.1 - 0.0095 15.8 0.0 0.027 14.4 0.0 1.8 1 0 0 1 1 1 1 F-box-like DDE_1 PF03184.19 EEA23679.1 - 6.2e-30 104.1 0.1 1.4e-29 102.9 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-CCHC_2 PF13696.6 EEA23679.1 - 0.0018 18.0 3.2 0.0033 17.2 3.2 1.5 1 0 0 1 1 1 1 Zinc knuckle Rrn6 PF10214.9 EEA23679.1 - 0.48 8.9 11.4 0.65 8.4 11.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor zf-CCHC PF00098.23 EEA23679.1 - 0.51 10.5 2.4 0.95 9.7 2.4 1.5 1 0 0 1 1 1 0 Zinc knuckle Nucleo_P87 PF07267.11 EEA23679.1 - 0.62 8.9 5.9 0.79 8.5 5.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PNP_UDP_1 PF01048.20 EEA23680.1 - 0.022 14.0 0.2 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Phosphorylase superfamily Ank_2 PF12796.7 EEA23681.1 - 2.3e-64 213.9 16.2 1.2e-15 57.8 0.0 8.3 5 3 3 8 8 8 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA23681.1 - 7.2e-52 173.1 14.6 2.1e-08 34.6 0.1 12.2 6 3 7 13 13 13 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA23681.1 - 6.6e-46 153.8 15.1 1.3e-07 31.7 0.0 12.5 5 2 7 12 12 12 9 Ankyrin repeats (many copies) Ank PF00023.30 EEA23681.1 - 2.3e-45 151.1 20.8 0.00042 20.6 0.1 13.0 12 0 0 12 12 12 10 Ankyrin repeat Ank_3 PF13606.6 EEA23681.1 - 9.6e-40 130.0 18.7 9.1e-05 22.6 0.0 14.7 15 0 0 15 15 15 9 Ankyrin repeat NACHT PF05729.12 EEA23681.1 - 0.00023 21.1 0.0 0.00061 19.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_14 PF13173.6 EEA23681.1 - 0.014 15.4 0.0 0.037 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA23681.1 - 0.017 15.5 0.0 0.047 14.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase PNP_UDP_1 PF01048.20 EEA23681.1 - 0.071 12.3 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Phosphorylase superfamily Glyco_hydro_3 PF00933.21 EEA23682.1 - 2e-12 47.2 0.0 2.1e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain DUF3435 PF11917.8 EEA23683.1 - 7.3e-146 486.4 2.3 1e-145 485.9 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) BNIP2 PF12496.8 EEA23683.1 - 0.41 11.1 8.8 1.3 9.4 8.8 1.8 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 zf-Di19 PF05605.12 EEA23683.1 - 1.6 9.1 4.0 1.1 9.6 0.6 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding YL1 PF05764.13 EEA23683.1 - 1.8 8.6 16.2 0.45 10.6 6.6 2.3 2 0 0 2 2 2 0 YL1 nuclear protein CENP-B_dimeris PF09026.10 EEA23683.1 - 8 6.9 16.2 29 5.2 16.2 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain WD40 PF00400.32 EEA23686.1 - 1.9e-124 401.9 33.1 2.9e-09 37.4 0.0 13.7 13 0 0 13 13 13 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA23686.1 - 8e-39 131.8 0.3 0.0024 18.2 0.0 11.4 1 1 9 11 11 11 11 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA23686.1 - 8.3e-14 51.9 0.0 0.017 15.0 0.0 5.3 1 1 5 7 7 7 6 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA23686.1 - 1e-13 51.0 13.1 1.5 7.8 0.0 11.3 1 1 12 13 13 13 4 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1652 PF07865.11 EEA23686.1 - 8.5e-13 47.9 0.2 0.23 11.3 0.0 8.9 9 1 1 10 10 8 2 Protein of unknown function (DUF1652) NACHT PF05729.12 EEA23686.1 - 1.8e-10 41.0 0.1 4.9e-10 39.6 0.1 1.8 1 0 0 1 1 1 1 NACHT domain Cytochrom_D1 PF02239.16 EEA23686.1 - 4.2e-09 35.4 0.2 0.37 9.3 0.0 4.8 2 1 4 6 6 6 3 Cytochrome D1 heme domain AAA_16 PF13191.6 EEA23686.1 - 1.3e-08 35.4 0.3 4.9e-08 33.6 0.1 2.1 2 0 0 2 2 2 1 AAA ATPase domain WD40_like PF17005.5 EEA23686.1 - 1.1e-07 31.5 0.0 0.1 11.9 0.0 5.0 4 1 1 7 7 7 2 WD40-like domain PQQ_2 PF13360.6 EEA23686.1 - 2e-06 27.6 18.4 0.012 15.3 0.6 4.5 1 1 3 4 4 4 3 PQQ-like domain Proteasome_A_N PF10584.9 EEA23686.1 - 1.3e-05 24.8 0.8 7.7 6.3 0.0 6.7 7 0 0 7 7 6 1 Proteasome subunit A N-terminal signature PD40 PF07676.12 EEA23686.1 - 2.9e-05 23.9 3.1 56 3.9 0.0 8.1 9 0 0 9 9 8 0 WD40-like Beta Propeller Repeat PNP_UDP_1 PF01048.20 EEA23686.1 - 3e-05 23.4 0.8 0.00011 21.5 0.8 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily AAA PF00004.29 EEA23686.1 - 0.002 18.5 0.4 0.0077 16.6 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IKI3 PF04762.12 EEA23686.1 - 0.0029 15.7 0.1 0.22 9.5 0.0 3.0 2 1 1 3 3 3 1 IKI3 family DUF4596 PF15363.6 EEA23686.1 - 0.0045 17.2 17.7 7.7 6.8 0.1 7.9 7 1 1 8 8 8 1 Domain of unknown function (DUF4596) PALB2_WD40 PF16756.5 EEA23686.1 - 0.0067 15.4 7.5 7.4 5.4 1.9 5.5 2 2 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain AAA_30 PF13604.6 EEA23686.1 - 0.034 13.8 0.0 0.075 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA23686.1 - 0.04 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EEA23686.1 - 0.041 13.1 0.0 0.092 11.9 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.6 EEA23686.1 - 0.052 13.9 0.0 0.6 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain TFIIIC_delta PF12657.7 EEA23686.1 - 0.16 11.9 3.2 32 4.4 0.0 5.1 5 1 0 5 5 5 0 Transcription factor IIIC subunit delta N-term DUF3435 PF11917.8 EEA23687.1 - 2e-112 376.2 0.0 2.9e-112 375.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) RRN3 PF05327.11 EEA23687.1 - 0.033 12.8 2.7 0.046 12.3 2.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.13 EEA23687.1 - 4.6 7.1 6.9 12 5.7 6.9 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region rve PF00665.26 EEA23688.1 - 2.4e-07 31.0 0.2 1.7e-06 28.2 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain Clr5 PF14420.6 EEA23688.1 - 0.00065 19.9 0.0 0.0047 17.1 0.0 2.3 2 0 0 2 2 2 1 Clr5 domain HTH_Tnp_Tc3_2 PF01498.18 EEA23688.1 - 0.0078 16.4 1.0 0.06 13.6 0.1 2.8 3 0 0 3 3 3 1 Transposase HTH_32 PF13565.6 EEA23688.1 - 0.01 16.4 0.4 0.07 13.7 0.0 2.7 3 0 0 3 3 3 0 Homeodomain-like domain PDZ_assoc PF10600.9 EEA23688.1 - 0.16 12.8 0.4 0.47 11.3 0.2 1.8 1 1 1 2 2 2 0 PDZ-associated domain of NMDA receptors Asp PF00026.23 EEA23690.1 - 4.7e-17 62.4 5.3 6.2e-17 62.0 5.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EEA23690.1 - 0.015 15.1 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Epimerase PF01370.21 EEA23691.1 - 9.6e-06 25.2 0.1 7e-05 22.4 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA23691.1 - 0.00017 21.6 0.1 0.00056 19.9 0.1 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EEA23691.1 - 0.0017 18.8 0.0 0.003 18.0 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EEA23691.1 - 0.0061 15.6 0.0 0.023 13.7 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EEA23691.1 - 0.0067 16.7 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 EEA23691.1 - 0.0094 15.5 0.5 0.15 11.6 0.2 2.3 3 0 0 3 3 3 1 NmrA-like family KR PF08659.10 EEA23691.1 - 0.013 15.4 0.2 0.026 14.4 0.2 1.4 1 0 0 1 1 1 0 KR domain TrkA_N PF02254.18 EEA23691.1 - 0.025 14.8 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_4 PF07993.12 EEA23691.1 - 0.067 12.3 0.2 2.5 7.2 0.1 2.2 2 0 0 2 2 2 0 Male sterility protein GDP_Man_Dehyd PF16363.5 EEA23691.1 - 0.069 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EEA23691.1 - 0.1 12.1 0.0 0.6 9.5 0.0 1.9 2 0 0 2 2 2 0 short chain dehydrogenase Shikimate_DH PF01488.20 EEA23691.1 - 0.11 12.6 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 EEA23691.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Aldo_ket_red PF00248.21 EEA23692.1 - 5.4e-34 117.7 0.0 7.2e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Sgf11_N PF18519.1 EEA23692.1 - 0.082 12.5 0.4 0.26 10.9 0.4 1.9 1 0 0 1 1 1 0 SAGA-associated factor 11 N-terminal domain Zn_clus PF00172.18 EEA23693.1 - 0.00041 20.4 11.2 0.00093 19.3 11.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SSPI PF14098.6 EEA23693.1 - 0.026 14.7 0.0 0.059 13.5 0.0 1.5 1 0 0 1 1 1 0 Small, acid-soluble spore protein I DUF1381 PF07129.11 EEA23694.1 - 0.17 11.8 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1381) FAD_binding_3 PF01494.19 EEA23695.1 - 2.2e-11 43.6 0.3 6.5e-05 22.3 0.1 2.4 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA23695.1 - 5.3e-06 26.6 0.7 1.2e-05 25.4 0.4 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA23695.1 - 0.00075 18.7 0.1 0.0016 17.6 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA23695.1 - 0.00076 18.8 0.0 0.013 14.8 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA23695.1 - 0.0016 17.2 0.1 0.0028 16.4 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EEA23695.1 - 0.0021 17.7 0.6 0.0044 16.7 0.6 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA23695.1 - 0.0026 18.3 0.1 0.071 13.7 0.0 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EEA23695.1 - 0.0042 16.4 0.1 0.007 15.7 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EEA23695.1 - 0.037 13.9 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EEA23695.1 - 0.043 12.9 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.14 EEA23695.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.17 EEA23695.1 - 0.071 12.3 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EEA23695.1 - 0.14 11.2 0.1 0.77 8.7 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_2 PF03446.15 EEA23695.1 - 0.16 12.1 0.1 0.63 10.2 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_23 PF13489.6 EEA23696.1 - 8e-13 48.5 0.0 1.2e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA23696.1 - 5.2e-07 30.3 0.0 1.5e-06 28.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA23696.1 - 1.4e-05 25.6 0.0 2.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA23696.1 - 0.0083 16.8 0.0 0.13 13.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA23696.1 - 0.032 13.6 0.0 0.43 9.9 0.0 2.3 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EEA23696.1 - 0.076 12.3 0.0 0.15 11.3 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain Methyltransf_31 PF13847.6 EEA23696.1 - 0.077 12.8 0.0 3.4 7.4 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EEA23696.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ammonium_transp PF00909.21 EEA23697.1 - 5.9e-73 245.9 20.1 6.7e-73 245.7 20.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family FMN_bind_2 PF04299.12 EEA23698.1 - 7.1e-59 198.3 0.1 8.3e-59 198.1 0.1 1.0 1 0 0 1 1 1 1 Putative FMN-binding domain Peptidase_A4 PF01828.17 EEA23699.1 - 3.2e-80 268.5 14.9 3.8e-80 268.3 14.9 1.1 1 0 0 1 1 1 1 Peptidase A4 family M60-like_N PF17291.2 EEA23699.1 - 0.039 13.8 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of M60-like peptidases FMO-like PF00743.19 EEA23700.1 - 2e-37 128.8 0.0 8.1e-21 74.0 0.0 3.0 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA23700.1 - 3.4e-13 49.5 0.3 5.2e-09 35.8 0.1 3.1 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA23700.1 - 1.6e-12 47.3 0.0 6.8e-12 45.2 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA23700.1 - 1.5e-08 34.2 0.3 9.9e-07 28.2 0.2 2.5 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EEA23700.1 - 2.5e-08 34.0 0.5 9.4e-07 28.9 0.8 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EEA23700.1 - 1.3e-07 31.6 0.1 0.0015 18.2 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA23700.1 - 5e-07 29.8 0.0 1.2e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA23700.1 - 3.6e-05 23.1 0.1 0.0043 16.3 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EEA23700.1 - 0.0062 17.1 0.3 0.18 12.4 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA23700.1 - 0.015 14.6 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EEA23700.1 - 0.022 14.1 0.0 0.043 13.2 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA23700.1 - 0.031 13.4 0.0 0.25 10.4 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 EEA23700.1 - 0.082 11.6 1.7 0.11 11.1 0.4 1.8 2 0 0 2 2 2 0 HI0933-like protein Glu_dehyd_C PF16912.5 EEA23700.1 - 0.14 11.6 0.0 3.9 6.9 0.0 2.2 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus MCRA PF06100.11 EEA23700.1 - 0.14 10.9 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 MCRA family GIDA PF01134.22 EEA23700.1 - 0.15 11.1 0.0 0.57 9.2 0.1 1.9 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EEA23700.1 - 0.21 10.8 0.1 0.36 10.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Fungal_trans_2 PF11951.8 EEA23701.1 - 6.2e-12 45.0 2.1 1.3e-11 44.0 2.1 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23702.1 - 6.7e-10 38.9 10.2 1.1e-09 38.3 10.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EEA23703.1 - 5.1e-40 137.3 7.4 6.9e-40 136.9 7.4 1.2 1 0 0 1 1 1 1 RTA1 like protein LHC PF00556.20 EEA23703.1 - 0.073 13.3 0.7 0.073 13.3 0.7 2.6 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit AA_permease PF00324.21 EEA23704.1 - 2.2e-121 405.8 31.8 2.5e-121 405.6 31.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA23704.1 - 8.4e-34 117.1 38.2 1e-33 116.8 38.2 1.0 1 0 0 1 1 1 1 Amino acid permease Asp PF00026.23 EEA23705.1 - 1.1e-65 222.1 2.4 1.4e-65 221.8 2.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA23705.1 - 3e-09 37.4 6.7 4.2e-06 27.1 0.0 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA23705.1 - 0.0015 19.1 5.8 0.019 15.6 0.3 3.5 3 1 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 EEA23705.1 - 0.0039 17.7 0.4 1.5 9.4 0.0 3.5 3 2 0 3 3 3 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EEA23705.1 - 0.07 12.9 0.0 1.3 8.8 0.0 2.3 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Iso_dh PF00180.20 EEA23706.1 - 3.8e-12 46.0 0.0 4.2e-12 45.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 EEA23707.1 - 1.4e-39 136.3 0.0 1.6e-39 136.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF4875 PF16175.5 EEA23707.1 - 0.063 13.4 0.0 0.17 12.0 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4875) Aminotran_5 PF00266.19 EEA23708.1 - 1.6e-21 76.7 0.0 2.3e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EEA23708.1 - 0.0026 16.3 0.0 0.0045 15.6 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Kelch_5 PF13854.6 EEA23711.1 - 7.6e-13 48.1 0.7 5.6e-12 45.4 0.3 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 EEA23711.1 - 0.00012 22.2 1.7 0.02 15.2 0.1 4.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EEA23711.1 - 0.00073 19.1 1.2 1.1 8.9 0.2 4.0 4 1 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EEA23711.1 - 0.00079 19.6 4.5 0.0047 17.2 0.5 3.8 3 1 1 4 4 4 1 Kelch motif SKG6 PF08693.10 EEA23711.1 - 0.0062 15.9 7.6 0.016 14.6 7.6 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TraL PF07178.11 EEA23711.1 - 0.18 12.3 0.1 23 5.5 0.1 2.6 2 0 0 2 2 2 0 TraL protein Transcrip_act PF04949.13 EEA23714.1 - 0.039 13.8 3.3 0.064 13.1 3.3 1.3 1 0 0 1 1 1 0 Transcriptional activator Syntaxin_2 PF14523.6 EEA23714.1 - 0.051 14.0 1.4 0.22 11.9 1.4 2.2 1 1 0 1 1 1 0 Syntaxin-like protein Hydantoinase_B PF02538.14 EEA23714.1 - 0.11 10.9 0.2 0.16 10.3 0.2 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase p450 PF00067.22 EEA23715.1 - 9.7e-51 172.9 0.0 1.2e-50 172.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Kelch_3 PF13415.6 EEA23716.1 - 7.2e-29 99.5 4.6 4e-07 30.2 0.0 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EEA23716.1 - 1.9e-28 98.2 15.1 6.8e-15 54.8 0.0 6.9 6 2 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EEA23716.1 - 7.3e-18 64.2 4.3 0.0036 17.5 0.0 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EEA23716.1 - 9.7e-18 63.5 6.1 0.018 14.6 0.0 6.9 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 EEA23716.1 - 2.5e-15 55.7 3.3 0.0084 16.1 0.0 6.1 5 2 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EEA23716.1 - 3.3e-11 42.9 0.7 0.018 15.0 0.0 5.7 6 0 0 6 6 6 3 Kelch motif PQQ_3 PF13570.6 EEA23716.1 - 0.016 15.7 3.8 3.4 8.3 0.0 4.7 5 1 0 5 5 5 0 PQQ-like domain Kelch_3 PF13415.6 EEA23717.1 - 7.2e-29 99.5 4.6 4e-07 30.2 0.0 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EEA23717.1 - 1.9e-28 98.2 15.1 6.8e-15 54.8 0.0 6.9 6 2 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EEA23717.1 - 7.3e-18 64.2 4.3 0.0036 17.5 0.0 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EEA23717.1 - 9.7e-18 63.5 6.1 0.018 14.6 0.0 6.9 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 EEA23717.1 - 2.5e-15 55.7 3.3 0.0084 16.1 0.0 6.1 5 2 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EEA23717.1 - 3.3e-11 42.9 0.7 0.018 15.0 0.0 5.7 6 0 0 6 6 6 3 Kelch motif PQQ_3 PF13570.6 EEA23717.1 - 0.016 15.7 3.8 3.4 8.3 0.0 4.7 5 1 0 5 5 5 0 PQQ-like domain Kelch_3 PF13415.6 EEA23718.1 - 7.2e-29 99.5 4.6 4e-07 30.2 0.0 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EEA23718.1 - 1.9e-28 98.2 15.1 6.8e-15 54.8 0.0 6.9 6 2 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EEA23718.1 - 7.3e-18 64.2 4.3 0.0036 17.5 0.0 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EEA23718.1 - 9.7e-18 63.5 6.1 0.018 14.6 0.0 6.9 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 EEA23718.1 - 2.5e-15 55.7 3.3 0.0084 16.1 0.0 6.1 5 2 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EEA23718.1 - 3.3e-11 42.9 0.7 0.018 15.0 0.0 5.7 6 0 0 6 6 6 3 Kelch motif PQQ_3 PF13570.6 EEA23718.1 - 0.016 15.7 3.8 3.4 8.3 0.0 4.7 5 1 0 5 5 5 0 PQQ-like domain FPN1 PF06963.12 EEA23719.1 - 8.8e-122 406.8 17.6 1e-121 406.6 17.6 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Acyl_transf_3 PF01757.22 EEA23720.1 - 6.4e-24 84.6 18.7 9.3e-24 84.1 18.7 1.2 1 0 0 1 1 1 1 Acyltransferase family TMEM223 PF14640.6 EEA23720.1 - 0.0078 16.4 0.5 0.017 15.3 0.5 1.6 1 0 0 1 1 1 1 Transmembrane protein 223 Dabb PF07876.12 EEA23721.1 - 1.1e-20 74.1 0.0 1.2e-20 73.9 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain adh_short PF00106.25 EEA23722.1 - 1.7e-28 99.4 0.0 2.4e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23722.1 - 1.2e-22 80.7 0.0 1.8e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23722.1 - 0.01 15.7 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 KR domain FMO-like PF00743.19 EEA23723.1 - 1.3e-13 50.3 0.2 4e-13 48.7 0.1 1.8 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA23723.1 - 1.2e-11 44.4 0.9 1e-09 38.1 0.7 3.0 1 1 2 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA23723.1 - 2.9e-10 40.2 0.0 7.2e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA23723.1 - 1.8e-09 37.8 0.1 3.7e-05 23.7 0.0 3.1 2 1 0 2 2 2 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 EEA23723.1 - 5.8e-09 35.5 0.5 1.7e-05 24.1 0.0 2.4 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EEA23723.1 - 2.4e-08 33.5 0.0 6.7e-06 25.5 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA23723.1 - 2.1e-05 24.3 3.3 0.0037 16.9 0.2 3.1 1 1 1 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 EEA23723.1 - 0.0024 17.2 0.1 0.039 13.2 0.1 2.2 2 0 0 2 2 2 1 Thi4 family FB_lectin PF07367.11 EEA23723.1 - 0.036 14.0 2.1 0.048 13.6 0.6 2.1 2 0 0 2 2 2 0 Fungal fruit body lectin Fungal_trans PF04082.18 EEA23724.1 - 5.1e-11 42.1 0.3 7.9e-11 41.5 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain TauD PF02668.16 EEA23727.1 - 2.1e-46 158.9 0.3 2.6e-46 158.6 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF3632 PF12311.8 EEA23728.1 - 6.2e-29 101.6 1.0 9e-29 101.1 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) A_deaminase PF00962.22 EEA23729.1 - 1.9e-41 142.5 0.0 2.4e-41 142.1 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Fungal_trans_2 PF11951.8 EEA23730.1 - 4.6e-31 108.0 3.0 9.8e-31 106.9 3.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA23730.1 - 0.00019 21.5 9.3 0.00041 20.4 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dpoe2NT PF12213.8 EEA23730.1 - 0.078 13.3 0.5 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal TPP_enzyme_N PF02776.18 EEA23731.1 - 1.9e-23 82.9 0.0 3.3e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA23731.1 - 1.9e-11 43.8 0.0 4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EEA23731.1 - 3.2e-10 40.0 0.4 8e-10 38.7 0.1 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fungal_trans_2 PF11951.8 EEA23732.1 - 2.6e-15 56.1 1.7 1.1e-14 54.1 1.7 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Aldedh PF00171.22 EEA23733.1 - 5e-139 463.8 0.0 6e-139 463.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family D-ser_dehydrat PF14031.6 EEA23734.1 - 5e-22 78.4 0.0 1.4e-21 77.0 0.0 1.8 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EEA23734.1 - 2e-09 37.4 0.0 2.8e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Gti1_Pac2 PF09729.9 EEA23734.1 - 0.005 17.0 0.1 0.0085 16.2 0.1 1.3 1 0 0 1 1 1 1 Gti1/Pac2 family ABC2_membrane PF01061.24 EEA23735.1 - 4.6e-86 287.6 44.5 2.9e-48 164.1 16.3 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EEA23735.1 - 1.7e-36 125.7 0.0 1.3e-17 64.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EEA23735.1 - 4.8e-28 96.9 9.7 3.8e-26 90.8 0.1 3.5 3 0 0 3 3 3 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EEA23735.1 - 9.6e-08 31.5 35.7 6.4e-05 22.2 15.0 2.5 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_16 PF13191.6 EEA23735.1 - 8.8e-06 26.2 0.0 0.019 15.4 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA23735.1 - 6e-05 23.0 0.2 0.01 15.7 0.0 2.6 3 0 0 3 3 3 1 RsgA GTPase AAA_25 PF13481.6 EEA23735.1 - 0.00016 21.3 0.1 0.0062 16.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA23735.1 - 0.00035 20.8 0.4 0.87 9.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EEA23735.1 - 0.00063 19.4 0.4 0.087 12.6 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA23735.1 - 0.00083 19.6 0.1 0.79 10.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EEA23735.1 - 0.0016 19.0 0.0 3 8.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EEA23735.1 - 0.0066 16.7 1.1 0.72 10.1 0.4 2.8 3 0 0 3 3 3 1 AAA domain ABC_trans_N PF14510.6 EEA23735.1 - 0.011 16.4 0.0 0.024 15.2 0.0 1.5 1 0 0 1 1 1 0 ABC-transporter N-terminal cobW PF02492.19 EEA23735.1 - 0.011 15.3 1.8 2 8.0 0.4 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EEA23735.1 - 0.016 15.2 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EEA23735.1 - 0.077 12.3 0.4 4.2 6.6 0.3 2.4 2 0 0 2 2 2 0 Zeta toxin MMR_HSR1 PF01926.23 EEA23735.1 - 0.12 12.5 0.3 23 5.1 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 EEA23735.1 - 0.15 11.8 0.8 5.3 6.7 0.4 2.3 2 0 0 2 2 2 0 AAA domain Med7 PF05983.11 EEA23736.1 - 5.9e-65 219.0 0.9 7.3e-65 218.6 0.9 1.1 1 0 0 1 1 1 1 MED7 protein Med7 PF05983.11 EEA23737.1 - 5.9e-65 219.0 0.9 7.3e-65 218.6 0.9 1.1 1 0 0 1 1 1 1 MED7 protein PAP2 PF01569.21 EEA23738.1 - 1.3e-29 102.7 0.4 1.3e-29 102.7 0.4 1.8 2 1 0 2 2 2 1 PAP2 superfamily Frag1 PF10277.9 EEA23738.1 - 0.015 14.8 1.6 0.05 13.1 1.0 2.0 1 1 1 2 2 2 0 Frag1/DRAM/Sfk1 family DUF5510 PF17629.2 EEA23738.1 - 0.25 11.3 0.1 0.25 11.3 0.1 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5510) PAP2 PF01569.21 EEA23739.1 - 1.4e-29 102.6 0.4 1.4e-29 102.6 0.4 1.9 2 1 0 2 2 2 1 PAP2 superfamily DUF5510 PF17629.2 EEA23739.1 - 0.27 11.2 0.1 0.27 11.2 0.1 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5510) SCP2 PF02036.17 EEA23740.1 - 1.5e-25 89.6 0.3 1.7e-25 89.4 0.3 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EEA23740.1 - 0.00014 22.2 0.1 0.00019 21.7 0.1 1.3 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 EEA23740.1 - 0.0055 17.1 0.0 0.0069 16.8 0.0 1.2 1 0 0 1 1 1 1 Sterol carrier protein domain Chorion_S16 PF05836.12 EEA23741.1 - 0.072 13.3 0.5 0.32 11.2 0.7 1.9 2 0 0 2 2 2 0 Chorion protein S16 Pectate_lyase_3 PF12708.7 EEA23742.1 - 1.3e-92 309.5 35.0 2.1e-82 276.1 12.2 3.9 4 1 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EEA23742.1 - 6.7e-06 25.7 5.3 0.025 14.3 0.7 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Vps36-NZF-N PF16988.5 EEA23743.1 - 0.047 13.1 3.6 0.1 12.0 3.6 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain CBP_BcsO PF17037.5 EEA23743.1 - 2.7 8.1 8.6 5.2 7.2 8.6 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsO Peptidase_M24 PF00557.24 EEA23746.1 - 1e-40 139.7 0.0 1.4e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 PGA2 PF07543.12 EEA23746.1 - 0.1 12.6 3.6 0.17 11.8 3.6 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 Nucleoporin_FG PF13634.6 EEA23748.1 - 8.6e-13 49.0 211.3 0.00027 21.7 9.5 12.1 2 2 10 12 12 12 8 Nucleoporin FG repeat region Ran_BP1 PF00638.18 EEA23748.1 - 2.1e-08 34.5 0.1 3.8e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 RanBP1 domain Ribosomal_L31e PF01198.19 EEA23749.1 - 2.7e-40 136.5 0.5 3.4e-40 136.1 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e MS_channel PF00924.18 EEA23749.1 - 0.056 13.0 0.0 0.067 12.7 0.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel CN_hydrolase PF00795.22 EEA23750.1 - 4e-60 203.4 0.0 4.5e-60 203.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Glyco_hydro_18 PF00704.28 EEA23753.1 - 4.9e-69 233.5 4.3 7.9e-69 232.8 4.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EEA23753.1 - 5.4e-21 74.4 0.0 1.7e-05 24.8 0.0 3.8 3 0 0 3 3 3 3 LysM domain ATG2_CAD PF13329.6 EEA23754.1 - 3e-46 157.0 0.0 7.9e-46 155.6 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EEA23754.1 - 4.9e-31 106.9 0.0 1.4e-30 105.5 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EEA23754.1 - 0.04 13.7 0.0 0.095 12.5 0.0 1.6 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EEA23754.1 - 0.042 13.6 0.0 0.098 12.4 0.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal A_deaminase PF00962.22 EEA23755.1 - 8.8e-24 84.4 0.0 1.4e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF1772 PF08592.11 EEA23756.1 - 0.00033 21.0 1.1 0.00033 21.0 1.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF1772) MFS_1 PF07690.16 EEA23758.1 - 2.9e-41 141.6 53.3 2.9e-41 141.6 53.3 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA23758.1 - 8.2e-18 64.2 14.1 1.2e-17 63.6 14.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA23758.1 - 1.7e-11 43.7 17.1 1.7e-11 43.7 17.1 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter EthD PF07110.11 EEA23759.1 - 2.5e-19 70.2 0.3 3.2e-19 69.9 0.3 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EEA23759.1 - 0.018 15.5 0.4 0.042 14.3 0.4 1.6 1 1 0 1 1 1 0 Methylmuconolactone methyl-isomerase Mannitol_dh_C PF08125.13 EEA23759.1 - 0.098 12.1 0.0 0.22 11.0 0.0 1.5 2 0 0 2 2 2 0 Mannitol dehydrogenase C-terminal domain EthD PF07110.11 EEA23760.1 - 2.5e-19 70.2 0.3 3.2e-19 69.9 0.3 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EEA23760.1 - 0.018 15.5 0.4 0.042 14.3 0.4 1.6 1 1 0 1 1 1 0 Methylmuconolactone methyl-isomerase Mannitol_dh_C PF08125.13 EEA23760.1 - 0.098 12.1 0.0 0.22 11.0 0.0 1.5 2 0 0 2 2 2 0 Mannitol dehydrogenase C-terminal domain ketoacyl-synt PF00109.26 EEA23761.1 - 1.8e-72 244.0 0.0 3.8e-72 242.9 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 EEA23761.1 - 5e-72 242.8 0.0 7.8e-72 242.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EEA23761.1 - 3.4e-51 174.4 0.0 6.2e-51 173.5 0.0 1.3 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 EEA23761.1 - 1e-50 172.1 0.0 1.2e-48 165.4 0.0 2.5 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EEA23761.1 - 2.4e-43 148.9 0.0 4.6e-43 147.9 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EEA23761.1 - 6.6e-40 137.2 0.0 1.3e-39 136.3 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase NAD_binding_4 PF07993.12 EEA23761.1 - 1.1e-32 113.2 0.0 3.3e-32 111.7 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein Ketoacyl-synt_C PF02801.22 EEA23761.1 - 1.9e-29 102.1 0.0 7.3e-29 100.2 0.0 2.1 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EEA23761.1 - 1.7e-17 63.5 0.7 6.3e-08 32.9 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 EEA23761.1 - 2.4e-17 63.5 0.0 9.8e-17 61.5 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EEA23761.1 - 4.7e-16 59.2 0.0 1.8e-15 57.4 0.0 2.1 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EEA23761.1 - 1.2e-13 51.5 0.0 1.4e-12 48.1 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Epimerase PF01370.21 EEA23761.1 - 4.7e-13 49.2 0.0 5.8e-11 42.3 0.0 2.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Methyltransf_11 PF08241.12 EEA23761.1 - 2.8e-11 43.9 0.0 1e-10 42.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA23761.1 - 1.1e-10 41.6 0.0 2.5e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA23761.1 - 1.5e-09 37.8 0.0 5.5e-09 36.0 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain adh_short PF00106.25 EEA23761.1 - 2.5e-09 36.9 0.0 1e-08 34.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase 3Beta_HSD PF01073.19 EEA23761.1 - 1.4e-06 27.5 0.0 3.2e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 EEA23761.1 - 1.5e-05 24.5 0.0 3.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EEA23761.1 - 3.7e-05 23.2 0.0 7.9e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 EEA23761.1 - 0.00038 21.5 0.0 0.003 18.6 0.0 2.7 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EEA23761.1 - 0.0017 18.0 0.0 0.0042 16.7 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase GDP_Man_Dehyd PF16363.5 EEA23761.1 - 0.0042 16.5 0.0 0.12 11.8 0.1 2.3 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Methyltransf_16 PF10294.9 EEA23761.1 - 0.0074 16.0 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase RrnaAD PF00398.20 EEA23761.1 - 0.041 13.0 0.0 0.073 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase ACP_syn_III PF08545.10 EEA23761.1 - 0.18 11.7 0.2 0.55 10.1 0.2 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III adh_short PF00106.25 EEA23762.1 - 1.1e-32 113.1 0.0 1.3e-32 112.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23762.1 - 3.6e-24 85.6 0.0 4.3e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23762.1 - 0.00021 21.3 0.0 0.0005 20.0 0.0 1.6 1 1 0 1 1 1 1 KR domain Nucleos_tra2_C PF07662.13 EEA23763.1 - 6.2e-72 241.8 1.0 6.2e-72 241.8 1.0 2.3 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EEA23763.1 - 1.7e-21 76.6 1.2 1.7e-21 76.6 1.2 2.7 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter N-terminus Sugar_tr PF00083.24 EEA23764.1 - 3.3e-94 316.3 25.5 3.8e-94 316.1 25.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23764.1 - 3.2e-26 92.1 35.0 5.4e-23 81.5 20.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5311 PF17238.2 EEA23764.1 - 0.028 14.3 0.3 9.7 6.0 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5311) Sugar_tr PF00083.24 EEA23765.1 - 3.3e-94 316.3 25.5 3.8e-94 316.1 25.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA23765.1 - 3.2e-26 92.1 35.0 5.4e-23 81.5 20.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5311 PF17238.2 EEA23765.1 - 0.028 14.3 0.3 9.7 6.0 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5311) GSu_C4xC__C2xCH PF09698.10 EEA23766.1 - 0.057 14.2 0.5 0.14 12.9 0.5 1.7 1 0 0 1 1 1 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) UQ_con PF00179.26 EEA23767.1 - 1.5e-49 167.3 0.0 1.8e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA23767.1 - 2.9e-05 23.8 0.0 5.1e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EEA23767.1 - 0.00041 20.6 0.0 0.00061 20.1 0.0 1.4 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 EEA23767.1 - 0.0038 17.1 0.0 0.0058 16.5 0.0 1.4 1 0 0 1 1 1 1 UEV domain Pkinase PF00069.25 EEA23768.1 - 3.9e-60 203.5 0.0 5e-60 203.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23768.1 - 2.7e-27 95.7 0.0 3.9e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA23768.1 - 1.6e-08 34.3 0.0 3.1e-08 33.3 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EEA23768.1 - 0.0044 16.4 0.0 0.055 12.8 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4926 PF16277.5 EEA23768.1 - 0.14 11.6 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4926) F-box-like PF12937.7 EEA23769.1 - 1.9e-09 37.2 0.2 4e-09 36.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA23769.1 - 3e-06 27.0 0.5 6.6e-06 25.9 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EEA23769.1 - 0.08 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 F-box DHBP_synthase PF00926.19 EEA23770.1 - 5.7e-77 257.6 0.0 6.8e-77 257.3 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase TFA2_Winged_2 PF18121.1 EEA23771.1 - 3.1e-22 78.0 4.1 8.8e-22 76.6 0.7 2.6 3 0 0 3 3 3 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EEA23771.1 - 2.1e-20 72.7 0.1 1.4e-19 70.1 0.0 2.3 2 1 0 2 2 2 1 TFIIE beta subunit core domain PhoQ_Sensor PF08918.10 EEA23771.1 - 0.075 12.9 0.2 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 PhoQ Sensor TPR_MLP1_2 PF07926.12 EEA23772.1 - 4.7e-34 117.2 31.2 4.7e-34 117.2 31.2 19.3 8 7 12 20 20 20 5 TPR/MLP1/MLP2-like protein KASH_CCD PF14662.6 EEA23772.1 - 9.5e-05 22.3 28.6 9.5e-05 22.3 28.6 13.8 5 5 6 13 13 13 2 Coiled-coil region of CCDC155 or KASH CENP-F_leu_zip PF10473.9 EEA23772.1 - 0.0056 16.7 16.5 0.0056 16.7 16.5 16.7 6 5 8 15 15 15 6 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Hexapep PF00132.24 EEA23773.1 - 3.1e-12 45.7 10.8 0.00059 19.5 1.4 4.4 2 2 2 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EEA23773.1 - 0.00064 19.4 0.7 0.00064 19.4 0.7 3.9 3 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Acid_PPase PF12689.7 EEA23775.1 - 8.1e-71 237.3 0.0 9.5e-71 237.1 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase NIF PF03031.18 EEA23775.1 - 0.087 12.6 0.0 0.18 11.6 0.0 1.5 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase WD40 PF00400.32 EEA23776.1 - 8e-42 140.4 14.8 5.5e-06 27.0 0.1 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EEA23776.1 - 1.5e-08 34.4 0.1 2.9e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA23776.1 - 8.1e-08 32.0 0.0 1.6e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EEA23776.1 - 2.1e-07 31.2 1.2 0.27 11.6 0.0 5.0 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EEA23776.1 - 0.00018 21.5 0.0 2.7 8.1 0.0 4.3 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 EEA23776.1 - 0.0024 16.6 8.3 2.7 6.5 0.1 5.2 5 1 1 6 6 6 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 EEA23776.1 - 0.029 14.0 0.2 4.8 6.7 0.0 2.5 1 1 0 2 2 2 0 PQQ-like domain WD40_like PF17005.5 EEA23776.1 - 0.041 13.2 0.0 1.9 7.7 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain F-box_4 PF15966.5 EEA23776.1 - 0.08 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 F-box LRR_6 PF13516.6 EEA23777.1 - 0.00021 21.1 1.7 4.4 7.6 0.1 3.8 3 0 0 3 3 3 2 Leucine Rich repeat LRR_8 PF13855.6 EEA23777.1 - 0.0008 19.1 0.7 0.62 9.9 0.1 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EEA23777.1 - 0.0011 19.4 2.0 0.0079 16.6 2.8 2.1 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EEA23777.1 - 0.091 13.4 0.1 23 6.0 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat adh_short PF00106.25 EEA23778.1 - 5.6e-23 81.4 0.0 7.1e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23778.1 - 7.1e-13 48.6 0.0 9.2e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23778.1 - 0.00036 20.5 0.0 0.00089 19.2 0.0 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA23778.1 - 0.00083 18.9 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family BES1_N PF05687.13 EEA23778.1 - 0.082 13.3 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal NAD_binding_4 PF07993.12 EEA23778.1 - 0.098 11.8 0.0 1.1 8.4 0.0 2.3 2 1 1 3 3 3 0 Male sterility protein Nuc_sug_transp PF04142.15 EEA23780.1 - 6.3e-78 262.1 8.6 7.9e-78 261.8 8.6 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UPF0182 PF03699.13 EEA23780.1 - 1.3 7.1 8.5 2 6.4 1.9 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) TPT PF03151.16 EEA23780.1 - 2.5 7.4 14.4 0.96 8.7 0.9 2.7 2 1 0 2 2 2 0 Triose-phosphate Transporter family Sec63 PF02889.16 EEA23781.1 - 1.3e-34 119.5 0.2 2.2e-34 118.8 0.2 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EEA23781.1 - 1.2e-25 90.3 0.0 2.4e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA23781.1 - 1.2e-11 44.9 0.0 3.6e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA23781.1 - 9.1e-08 32.4 0.0 3.4e-07 30.6 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EEA23781.1 - 0.00023 21.4 0.0 0.00093 19.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA23781.1 - 0.0014 19.0 0.3 0.0085 16.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EEA23781.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EEA23781.1 - 0.097 13.1 0.0 0.32 11.4 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Helicase_RecD PF05127.14 EEA23781.1 - 0.099 12.5 0.1 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Helicase T2SSE PF00437.20 EEA23781.1 - 0.13 11.3 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein HHH_5 PF14520.6 EEA23781.1 - 0.15 12.7 0.1 0.42 11.3 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain MMR_HSR1 PF01926.23 EEA23782.1 - 5.5e-18 65.1 0.0 1.1e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EEA23782.1 - 1e-05 25.6 0.0 0.004 17.2 0.0 2.4 2 0 0 2 2 2 2 Dynamin family FeoB_N PF02421.18 EEA23782.1 - 2.3e-05 24.0 0.0 3.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EEA23782.1 - 2.8e-05 24.1 0.2 0.00094 19.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EEA23782.1 - 3.7e-05 23.4 0.1 0.0024 17.5 0.1 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EEA23782.1 - 0.0018 17.6 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 AIG1 family AAA_29 PF13555.6 EEA23782.1 - 0.016 15.0 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRPRB PF09439.10 EEA23782.1 - 0.016 14.6 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 EEA23782.1 - 0.022 15.0 0.5 0.06 13.6 0.1 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IIGP PF05049.13 EEA23782.1 - 0.045 12.8 0.0 0.096 11.7 0.0 1.5 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 EEA23782.1 - 0.066 13.7 0.1 0.14 12.6 0.1 1.5 1 1 0 1 1 1 0 ABC transporter Clat_adaptor_s PF01217.20 EEA23783.1 - 1.6e-43 148.1 0.0 4.8e-43 146.5 0.0 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Ribosomal_L7Ae PF01248.26 EEA23784.1 - 1e-22 79.7 0.5 1.6e-22 79.0 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CLPTM1 PF05602.12 EEA23784.1 - 0.017 14.2 0.3 0.022 13.8 0.3 1.2 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) adh_short PF00106.25 EEA23785.1 - 6.9e-23 81.1 0.0 8.6e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23785.1 - 3.4e-19 69.3 0.0 4.3e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23785.1 - 4.1e-11 43.1 0.1 5.6e-11 42.7 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA23785.1 - 0.00035 20.1 0.0 0.0013 18.3 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EEA23785.1 - 0.047 13.8 0.0 0.091 12.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EEA23785.1 - 0.047 13.6 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EEA23785.1 - 0.16 11.1 0.1 0.43 9.7 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein CLASP_N PF12348.8 EEA23786.1 - 1.3e-08 34.7 0.1 1e-06 28.5 0.1 2.9 2 1 0 2 2 2 1 CLASP N terminal HEAT_2 PF13646.6 EEA23786.1 - 4.6e-06 26.9 1.6 0.017 15.5 0.0 4.6 3 2 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EEA23786.1 - 8.1e-05 22.6 1.7 4 7.9 0.5 4.7 4 0 0 4 4 4 2 HEAT repeat TAN PF11640.8 EEA23786.1 - 0.0003 20.9 0.1 0.002 18.3 0.1 2.3 1 1 0 1 1 1 1 Telomere-length maintenance and DNA damage repair Cnd1 PF12717.7 EEA23786.1 - 0.00035 20.7 1.0 1.4 9.0 0.2 3.0 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EEA23786.1 - 0.00068 18.3 2.2 0.007 15.0 2.2 2.6 1 1 0 1 1 1 1 Adaptin N terminal region Golgin_A5 PF09787.9 EEA23786.1 - 0.12 11.8 10.3 0.28 10.6 10.3 1.5 1 0 0 1 1 1 0 Golgin subfamily A member 5 YnfE PF17452.2 EEA23786.1 - 0.16 12.2 0.2 14 6.1 0.1 2.7 2 0 0 2 2 2 0 Uncharacterized YnfE-like G-gamma PF00631.22 EEA23786.1 - 0.33 11.0 6.8 0.15 12.1 0.5 2.9 2 0 0 2 2 2 0 GGL domain Spc7 PF08317.11 EEA23786.1 - 0.51 9.2 10.8 1.2 7.9 10.8 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 EEA23786.1 - 0.94 6.9 9.8 1.7 6.1 9.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DAO PF01266.24 EEA23787.1 - 1.2e-38 133.6 0.0 1.5e-38 133.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA23787.1 - 2.2e-06 27.1 0.0 3.7e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EEA23787.1 - 1.4e-05 25.2 0.0 3.1e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EEA23787.1 - 0.00016 21.1 0.0 0.092 12.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA23787.1 - 0.0002 20.5 0.0 0.00028 20.0 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EEA23787.1 - 0.001 19.1 0.1 0.002 18.2 0.1 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EEA23787.1 - 0.0045 16.2 0.0 0.0077 15.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA23787.1 - 0.007 15.5 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EEA23787.1 - 0.014 15.9 0.3 0.41 11.3 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA23787.1 - 0.015 14.7 0.0 0.025 13.9 0.0 1.5 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase DUF2931 PF11153.8 EEA23787.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2931) K_oxygenase PF13434.6 EEA23787.1 - 0.087 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Mqo PF06039.15 EEA23787.1 - 0.25 9.8 0.1 0.36 9.3 0.1 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Chorismate_bind PF00425.18 EEA23788.1 - 6.2e-91 304.5 0.0 8.9e-91 304.0 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EEA23788.1 - 2.3e-28 99.2 0.0 2.5e-24 86.1 0.0 3.2 3 1 0 3 3 3 2 Anthranilate synthase component I, N terminal region Phage_holin_3_1 PF05106.12 EEA23788.1 - 0.14 12.6 0.0 4.3 7.8 0.0 2.5 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) POR PF01558.18 EEA23788.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase ATG16 PF08614.11 EEA23789.1 - 0.0014 18.9 7.5 0.065 13.5 0.1 2.6 2 1 1 3 3 3 2 Autophagy protein 16 (ATG16) Fungal_trans_2 PF11951.8 EEA23789.1 - 0.0036 16.2 0.8 0.0062 15.4 0.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mod_r PF07200.13 EEA23789.1 - 0.028 14.5 1.0 0.26 11.4 0.7 2.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CCDC-167 PF15188.6 EEA23789.1 - 0.036 14.4 2.3 0.12 12.7 2.3 1.9 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 EEA23789.1 - 0.22 11.6 1.4 0.93 9.5 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) ANAPC4_WD40 PF12894.7 EEA23790.1 - 4.5e-09 36.5 0.3 0.51 10.7 0.0 5.6 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA23790.1 - 4.2e-05 23.5 0.1 0.0003 20.7 0.0 2.5 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EEA23790.1 - 0.00012 22.8 9.3 3.2 8.8 0.1 6.9 7 0 0 7 7 7 1 WD domain, G-beta repeat IKI3 PF04762.12 EEA23790.1 - 0.16 9.9 0.2 0.64 7.9 0.0 1.9 1 1 1 2 2 2 0 IKI3 family Ge1_WD40 PF16529.5 EEA23790.1 - 0.64 8.9 2.7 3.6 6.5 0.8 2.5 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1751 PF08551.10 EEA23791.1 - 2.7e-29 101.7 3.6 6.3e-29 100.5 3.6 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EEA23791.1 - 9.7e-05 22.4 8.9 0.00019 21.4 8.9 1.5 1 0 0 1 1 1 1 Rhomboid family L51_S25_CI-B8 PF05047.16 EEA23792.1 - 2.9e-11 43.1 0.0 4.8e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain BRCT_3 PF18428.1 EEA23792.1 - 0.021 14.9 0.1 0.041 14.0 0.1 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain tRNA-synt_1 PF00133.22 EEA23793.1 - 1.3e-37 129.4 0.0 1.9e-27 95.8 0.0 3.1 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EEA23793.1 - 1.7e-15 57.3 0.1 3.4e-15 56.3 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EEA23793.1 - 4e-15 55.5 0.0 5.2e-10 38.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EEA23793.1 - 7.2e-08 32.1 0.0 2.3e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EEA23793.1 - 0.049 12.5 0.0 0.13 11.1 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (K) ENTH PF01417.20 EEA23794.1 - 1.1e-46 158.0 0.0 1.6e-46 157.4 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EEA23794.1 - 0.00017 20.7 0.0 0.00025 20.1 0.0 1.2 1 0 0 1 1 1 1 ANTH domain UIM PF02809.20 EEA23794.1 - 0.00073 19.3 4.3 0.0068 16.2 0.6 2.7 2 0 0 2 2 2 1 Ubiquitin interaction motif DUF1720 PF08226.11 EEA23794.1 - 0.0017 18.7 28.7 0.0017 18.7 28.7 4.5 2 2 1 3 3 3 1 Domain of unknown function (DUF1720) DUF4264 PF14084.6 EEA23794.1 - 0.0056 16.3 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4264) TMEM219 PF14940.6 EEA23794.1 - 0.22 11.1 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 Transmembrane 219 MMR_HSR1 PF01926.23 EEA23795.1 - 5.8e-05 23.1 0.1 0.047 13.8 0.0 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase PLU-1 PF08429.11 EEA23795.1 - 0.019 14.1 1.2 0.043 13.0 1.2 1.6 1 1 0 1 1 1 0 PLU-1-like protein RsgA_GTPase PF03193.16 EEA23795.1 - 0.041 13.8 0.0 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 RsgA GTPase ATPase-cat_bd PF12156.8 EEA23795.1 - 0.13 13.0 0.0 0.3 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase YozE_SAM_like PF06855.12 EEA23795.1 - 0.25 11.6 0.8 1.1 9.4 0.0 2.4 3 0 0 3 3 3 0 YozE SAM-like fold Dynamin_N PF00350.23 EEA23795.1 - 0.31 11.1 2.1 7 6.7 0.2 2.8 2 1 1 3 3 3 0 Dynamin family Sde2_N_Ubi PF13019.6 EEA23796.1 - 8.7e-72 240.3 0.5 1.5e-71 239.6 0.5 1.4 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain GET2 PF08690.10 EEA23796.1 - 1.7 8.2 4.9 2.5 7.7 4.9 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 S10_plectin PF03501.15 EEA23797.1 - 1.7e-41 140.2 0.1 2.1e-41 139.9 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain HEAT_2 PF13646.6 EEA23799.1 - 5.8e-19 68.3 1.2 1.8e-05 25.0 0.0 4.3 1 1 4 5 5 5 5 HEAT repeats HEAT_EZ PF13513.6 EEA23799.1 - 4.9e-10 39.7 0.0 4.1 8.0 0.0 6.4 5 2 2 7 7 7 2 HEAT-like repeat HEAT PF02985.22 EEA23799.1 - 6.1e-09 35.4 0.0 1.9 9.0 0.0 5.5 6 0 0 6 6 6 2 HEAT repeat CTK3 PF12243.8 EEA23799.1 - 8.5e-06 25.8 1.4 0.064 13.3 0.1 3.4 2 1 1 3 3 3 2 CTD kinase subunit gamma CTK3 U3snoRNP10 PF12397.8 EEA23799.1 - 0.0023 18.3 0.8 1.5 9.2 0.2 3.9 1 1 0 2 2 2 1 U3 small nucleolar RNA-associated protein 10 F-box-like PF12937.7 EEA23799.1 - 0.0023 17.8 3.5 30 4.6 0.0 4.8 5 1 0 5 5 4 0 F-box-like VHS PF00790.19 EEA23799.1 - 0.003 17.4 3.9 0.2 11.5 0.0 3.5 2 2 2 4 4 4 1 VHS domain Glyco_trans_2_3 PF13632.6 EEA23799.1 - 0.0054 16.7 0.1 2.3 8.1 0.0 3.6 3 1 1 4 4 4 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EEA23799.1 - 0.019 14.5 0.0 0.059 12.9 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 21 F-box PF00646.33 EEA23799.1 - 0.03 14.2 0.5 76 3.3 0.0 5.1 6 0 0 6 6 6 0 F-box domain FhuF PF06276.12 EEA23799.1 - 0.074 13.5 0.0 3.2 8.1 0.0 3.2 4 0 0 4 4 4 0 Ferric iron reductase FhuF-like transporter A_thal_3526 PF09713.10 EEA23799.1 - 0.08 13.2 0.0 10 6.5 0.0 3.6 4 1 1 5 5 5 0 Plant protein 1589 of unknown function (A_thal_3526) NACHT PF05729.12 EEA23800.1 - 4.7e-17 62.4 0.1 1.6e-16 60.7 0.0 2.0 2 0 0 2 2 2 1 NACHT domain PNP_UDP_1 PF01048.20 EEA23800.1 - 3.7e-13 49.3 0.0 6.7e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily NB-ARC PF00931.22 EEA23800.1 - 1.5e-07 30.9 0.0 2.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 EEA23800.1 - 0.0024 18.2 0.1 0.013 15.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA23800.1 - 0.015 15.9 0.0 0.034 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA23800.1 - 0.025 14.5 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.6 EEA23800.1 - 0.025 14.6 0.0 0.076 13.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA23800.1 - 0.027 14.9 0.1 0.19 12.1 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EEA23800.1 - 0.037 14.4 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 EEA23800.1 - 0.048 14.1 0.0 0.29 11.6 0.0 2.4 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EEA23800.1 - 0.063 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EEA23800.1 - 0.072 12.8 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EEA23800.1 - 0.08 13.4 0.0 0.29 11.5 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EEA23800.1 - 0.18 11.1 0.1 2.9 7.2 0.0 2.1 2 0 0 2 2 2 0 KaiC TerC PF03741.16 EEA23800.1 - 0.48 10.1 1.4 0.82 9.3 1.4 1.3 1 0 0 1 1 1 0 Integral membrane protein TerC family HIT PF01230.23 EEA23801.1 - 2e-23 82.9 0.1 2.7e-23 82.5 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EEA23801.1 - 2.5e-13 50.5 0.0 3.5e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EEA23801.1 - 0.00026 20.9 0.0 0.00034 20.5 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CRAL_TRIO PF00650.20 EEA23802.1 - 2.3e-43 147.7 0.1 5.6e-43 146.4 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA23802.1 - 6e-15 55.2 0.1 1.7e-14 53.7 0.1 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EEA23802.1 - 1.5e-05 25.2 0.0 2.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Retrotrans_gag PF03732.17 EEA23802.1 - 0.11 12.8 1.1 12 6.3 0.1 2.6 2 0 0 2 2 2 0 Retrotransposon gag protein DASH_Dam1 PF08653.10 EEA23803.1 - 1.5e-29 101.6 2.5 2e-29 101.2 2.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 UCH PF00443.29 EEA23804.1 - 1.1e-45 156.2 0.2 1.5e-45 155.7 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA23804.1 - 4.8e-18 65.8 8.2 1.8e-17 64.0 3.8 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EEA23804.1 - 9.1e-06 25.9 2.1 4.8e-05 23.6 0.9 2.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein DUF3973 PF13119.6 EEA23804.1 - 0.096 12.8 3.8 0.1 12.7 1.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3973) Ytp1 PF10355.9 EEA23805.1 - 3.3e-115 384.1 10.1 5.1e-115 383.4 10.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EEA23805.1 - 5.7e-26 90.3 13.2 6.6e-26 90.2 8.9 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) DUF3382 PF11862.8 EEA23805.1 - 1.6 9.1 7.0 11 6.3 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) DUF4131 PF13567.6 EEA23805.1 - 1.9 8.1 5.3 2.3 7.8 0.4 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) Rhomboid PF01694.22 EEA23806.1 - 7.4e-18 65.0 11.0 7.4e-18 65.0 11.0 1.5 2 0 0 2 2 2 1 Rhomboid family Gaa1 PF04114.14 EEA23807.1 - 3.9e-187 623.2 6.6 4.7e-187 623.0 6.6 1.0 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.27 EEA23808.1 - 5.6e-09 36.5 0.0 1.4e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EEA23808.1 - 5.9e-05 22.6 0.9 0.00012 21.5 0.9 1.5 1 0 0 1 1 1 1 Rpn9 C-terminal helix Methyltransf_23 PF13489.6 EEA23809.1 - 1.4e-15 57.6 0.0 1.8e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA23809.1 - 2.3e-13 50.2 0.0 2.6e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA23809.1 - 3.1e-13 50.2 0.0 1.8e-12 47.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA23809.1 - 3.6e-12 46.8 0.0 7.9e-12 45.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA23809.1 - 3.2e-11 43.8 0.0 3.7e-10 40.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA23809.1 - 6.9e-09 35.4 0.0 1.3e-08 34.5 0.0 1.4 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EEA23809.1 - 0.0097 15.9 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EEA23809.1 - 0.043 13.1 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase NmrA PF05368.13 EEA23810.1 - 8.8e-15 54.9 0.0 1.2e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EEA23810.1 - 4.2e-14 52.6 0.0 7.4e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA23810.1 - 5e-13 49.4 0.0 7.2e-13 48.8 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA23810.1 - 5.8e-11 41.9 0.0 1.1e-10 41.0 0.0 1.4 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EEA23810.1 - 1.2e-07 31.1 0.0 2.2e-06 27.0 0.0 2.4 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EEA23810.1 - 1.6e-07 31.1 0.1 8.1e-07 28.7 0.1 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EEA23810.1 - 0.00019 20.7 0.1 0.01 15.0 0.1 2.7 1 1 1 2 2 2 1 Male sterility protein adh_short PF00106.25 EEA23810.1 - 0.00039 19.9 0.0 0.00066 19.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA23810.1 - 0.0047 16.9 0.0 0.46 10.4 0.0 3.0 2 1 0 2 2 2 1 KR domain DUF4838 PF16126.5 EEA23810.1 - 0.01 15.3 0.0 0.79 9.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4838) Polysacc_synt_2 PF02719.15 EEA23810.1 - 0.093 11.9 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short_C2 PF13561.6 EEA23810.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EEA23811.1 - 1e-07 32.0 0.0 1.6e-07 31.4 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA23811.1 - 1.7e-07 31.0 0.0 2.5e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EEA23811.1 - 7.3e-06 25.6 0.0 1.5e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA23811.1 - 2.9e-05 23.2 0.0 6.3e-05 22.1 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EEA23811.1 - 0.00085 18.5 0.1 0.013 14.6 0.1 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain DUF4838 PF16126.5 EEA23811.1 - 0.0046 16.4 0.0 0.53 9.6 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4838) DDE_3 PF13358.6 EEA23812.1 - 7.4e-13 48.5 0.1 2.1e-12 47.0 0.1 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA23812.1 - 6.5e-10 39.1 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA23812.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA23812.1 - 0.0078 16.1 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA23812.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA23812.1 - 0.012 16.0 0.1 13 6.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA23812.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA23812.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA23812.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA23812.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA23812.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 Mog1 PF04603.12 EEA23813.1 - 3.8e-27 95.3 0.0 5.6e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Ran-interacting Mog1 protein DUF1907 PF08925.11 EEA23814.1 - 1.5e-107 359.3 0.0 1.7e-107 359.1 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) Sec23_trunk PF04811.15 EEA23815.1 - 8.4e-70 235.1 0.0 1.5e-69 234.2 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EEA23815.1 - 1.1e-22 79.8 0.0 3.6e-22 78.1 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EEA23815.1 - 3.5e-17 62.9 0.0 8.2e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EEA23815.1 - 8.7e-17 60.9 5.0 1.5e-16 60.1 5.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EEA23815.1 - 9.6e-09 35.0 0.0 2.2e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EEA23815.1 - 0.027 13.9 0.1 0.06 12.7 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Kinesin PF00225.23 EEA23816.1 - 5.4e-83 278.7 0.0 8.3e-83 278.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EEA23816.1 - 1e-21 77.5 0.0 2.1e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding HHH PF00633.23 EEA23816.1 - 0.00028 20.6 0.2 0.13 12.2 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_5 PF14520.6 EEA23816.1 - 0.011 16.4 3.6 0.14 12.8 0.4 3.2 2 1 1 3 3 3 0 Helix-hairpin-helix domain KLRAQ PF10205.9 EEA23816.1 - 0.055 13.7 0.7 3.9 7.8 0.4 2.8 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein HEM4 PF02602.15 EEA23817.1 - 2.6e-37 128.4 0.0 6e-37 127.2 0.0 1.6 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD NYN PF01936.18 EEA23818.1 - 7.7e-05 23.2 0.0 0.00031 21.2 0.0 2.2 1 1 0 1 1 1 1 NYN domain HSP9_HSP12 PF04119.12 EEA23819.1 - 4.3e-26 91.1 6.9 4.3e-26 91.1 6.9 1.6 2 0 0 2 2 2 1 Heat shock protein 9/12 YtxH PF12732.7 EEA23819.1 - 0.56 10.8 3.0 4.2 8.0 3.0 2.1 1 1 0 1 1 1 0 YtxH-like protein SEO_N PF14576.6 EEA23820.1 - 0.013 14.7 0.2 0.025 13.7 0.2 1.4 1 0 0 1 1 1 0 Sieve element occlusion N-terminus GIT_CC PF16559.5 EEA23820.1 - 0.013 15.3 4.1 0.13 12.1 0.2 2.9 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Fib_alpha PF08702.10 EEA23820.1 - 0.26 11.5 6.5 2 8.6 1.1 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EEA23820.1 - 0.3 11.4 10.3 2.5 8.5 4.9 3.9 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 EEA23820.1 - 0.42 11.1 5.9 3 8.4 0.2 3.5 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Takusan PF04822.13 EEA23820.1 - 0.45 10.4 7.4 0.12 12.3 1.5 2.9 3 1 0 3 3 3 0 Takusan APG6_N PF17675.1 EEA23820.1 - 1.2 9.7 24.3 1.3 9.6 2.5 3.2 2 1 1 3 3 3 0 Apg6 coiled-coil region FapA PF03961.13 EEA23820.1 - 1.8 7.1 6.9 2.8 6.5 4.2 2.1 1 1 2 3 3 3 0 Flagellar Assembly Protein A Occludin_ELL PF07303.13 EEA23820.1 - 2.4 8.9 6.5 14 6.5 0.7 3.5 3 1 1 4 4 4 0 Occludin homology domain GAS PF13851.6 EEA23820.1 - 3.7 6.8 15.4 0.12 11.8 2.9 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Nsp1_C PF05064.13 EEA23820.1 - 9.1 6.1 9.9 25 4.7 0.1 3.2 1 1 2 3 3 3 0 Nsp1-like C-terminal region POTRA_TamA_1 PF17243.2 EEA23820.1 - 9.4 6.4 6.9 2.6 8.2 1.3 2.8 3 0 0 3 3 3 0 POTRA domain TamA domain 1 COG6 PF06419.11 EEA23821.1 - 2.3e-209 696.7 0.8 2.6e-209 696.6 0.8 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 COG2 PF06148.11 EEA23821.1 - 0.00026 21.1 1.7 0.0016 18.6 0.3 2.9 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 EEA23821.1 - 0.036 14.3 0.6 0.12 12.6 0.4 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4054 PF13262.6 EEA23821.1 - 0.11 12.5 0.1 0.46 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4054) Forkhead PF00250.18 EEA23821.1 - 0.16 12.2 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Forkhead domain NIF3 PF01784.18 EEA23822.1 - 3.1e-57 194.0 0.0 3.8e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.18 EEA23823.1 - 2.7e-18 66.0 0.0 6.5e-18 64.8 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein Redoxin PF08534.10 EEA23824.1 - 2.6e-28 98.6 0.0 3.1e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EEA23824.1 - 3.4e-07 30.2 0.0 4.4e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Ras PF00071.22 EEA23825.1 - 2.8e-52 176.6 0.0 3.4e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA23825.1 - 5.2e-19 68.6 0.0 9.4e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA23825.1 - 5e-10 39.1 0.0 7.6e-10 38.5 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA23825.1 - 2.2e-05 24.1 0.1 0.00019 21.0 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EEA23825.1 - 0.0001 22.3 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA23825.1 - 0.0015 18.4 0.2 1.5 8.7 0.1 2.3 1 1 1 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EEA23825.1 - 0.042 14.1 0.4 0.53 10.6 0.1 2.5 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 EEA23825.1 - 0.085 12.1 0.0 1.6 7.9 0.0 2.2 1 1 1 2 2 2 0 Septin AAA_16 PF13191.6 EEA23825.1 - 0.2 12.0 1.1 1.5 9.2 1.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain Carboxyl_trans PF01039.22 EEA23826.1 - 2.1e-137 458.8 0.1 2.5e-137 458.5 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Acyl-CoA_dh_1 PF00441.24 EEA23827.1 - 3.7e-40 137.6 0.3 5.7e-40 137.0 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA23827.1 - 4.9e-30 104.5 0.0 8.9e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA23827.1 - 3.8e-27 94.3 0.1 7.6e-27 93.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA23827.1 - 7.7e-16 58.6 0.0 1.2e-15 58.0 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EEA23827.1 - 0.00078 19.2 0.0 0.0028 17.4 0.0 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_1 PF00441.24 EEA23828.1 - 2.4e-40 138.2 0.3 3.6e-40 137.6 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EEA23828.1 - 2.9e-27 94.7 0.1 5.2e-27 93.9 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EEA23828.1 - 4.7e-21 75.6 0.2 9.1e-21 74.6 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EEA23828.1 - 5.2e-16 59.1 0.0 7.9e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EEA23828.1 - 0.00054 19.7 0.1 0.002 17.9 0.1 1.8 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HSP70 PF00012.20 EEA23829.1 - 3e-13 48.8 0.0 1.2e-12 46.8 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA23829.1 - 3.3e-08 32.7 0.8 0.00067 18.6 0.1 2.3 2 0 0 2 2 2 2 MreB/Mbl protein StbA PF06406.11 EEA23829.1 - 0.21 10.8 0.6 12 5.0 0.0 2.1 2 0 0 2 2 2 0 StbA protein HAP1_N PF04849.13 EEA23830.1 - 0.067 12.4 21.5 0.12 11.6 21.5 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF4164 PF13747.6 EEA23830.1 - 0.43 10.9 11.3 3 8.2 9.4 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) CLZ PF16526.5 EEA23830.1 - 4.9 7.6 15.3 4.3 7.8 7.5 2.8 1 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3883 PF13020.6 EEA23831.1 - 0.0051 16.8 0.0 0.024 14.6 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3883) MPDZ_u10 PF16667.5 EEA23831.1 - 0.035 15.0 1.3 0.088 13.7 1.3 1.6 1 0 0 1 1 1 0 Unstructured region 10 on multiple PDZ protein Ank_2 PF12796.7 EEA23832.1 - 6.8e-20 71.4 0.0 1e-08 35.6 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA23832.1 - 1.9e-16 60.2 0.3 2.9e-05 24.5 0.0 4.5 2 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA23832.1 - 4.7e-14 52.1 0.0 0.27 11.7 0.0 7.1 7 0 0 7 7 7 3 Ankyrin repeat Ank_3 PF13606.6 EEA23832.1 - 4.6e-13 48.1 0.0 1.9 9.3 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EEA23832.1 - 8.9e-05 22.7 0.2 4 7.9 0.0 4.7 3 2 2 5 5 5 2 Ankyrin repeats (many copies) DUF416 PF04222.12 EEA23832.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF416) Abhydrolase_3 PF07859.13 EEA23833.1 - 3.2e-46 157.9 0.0 4.3e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA23833.1 - 0.0098 14.8 0.0 0.02 13.8 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family GST_C_2 PF13410.6 EEA23833.1 - 0.071 13.1 0.0 0.51 10.4 0.0 2.3 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Abhydrolase_6 PF12697.7 EEA23833.1 - 0.072 13.7 0.0 0.091 13.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family APH PF01636.23 EEA23835.1 - 3.2e-07 30.5 0.3 1.7e-05 24.9 0.3 2.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EEA23836.1 - 9e-09 35.1 0.0 4.2e-08 32.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23836.1 - 0.0025 17.1 0.2 0.0041 16.4 0.1 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1489 PF07370.11 EEA23836.1 - 0.16 11.7 0.0 13 5.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1489) Ank_2 PF12796.7 EEA23837.1 - 4.2e-28 97.8 0.9 2.3e-14 53.7 0.2 3.4 3 1 0 3 3 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA23837.1 - 3.9e-22 78.0 6.4 8.7e-06 25.9 0.1 5.8 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA23837.1 - 1.3e-20 71.2 1.5 0.0025 18.2 0.0 6.1 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EEA23837.1 - 3.9e-19 68.2 1.9 0.011 16.2 0.0 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EEA23837.1 - 5.9e-17 61.8 4.8 2e-06 28.2 0.2 4.6 3 1 2 5 5 4 3 Ankyrin repeats (many copies) NACHT PF05729.12 EEA23837.1 - 5.1e-08 33.0 0.0 1.3e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 EEA23837.1 - 0.00045 19.5 0.1 0.32 10.2 0.0 2.6 2 1 0 2 2 2 2 Phosphorylase superfamily AAA_16 PF13191.6 EEA23837.1 - 0.0014 19.1 0.1 0.0088 16.4 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 EEA23837.1 - 0.0085 16.5 0.0 0.038 14.4 0.0 2.2 2 0 0 2 2 2 1 RNA helicase Ribosomal_S15 PF00312.22 EEA23837.1 - 0.069 13.4 0.3 0.19 12.0 0.3 1.7 1 0 0 1 1 1 0 Ribosomal protein S15 CTD_bind PF04818.13 EEA23837.1 - 0.12 13.2 0.7 12 6.8 0.0 3.4 3 0 0 3 3 3 0 RNA polymerase II-binding domain. AAA_14 PF13173.6 EEA23837.1 - 0.14 12.1 0.0 0.71 9.9 0.0 2.3 1 0 0 1 1 1 0 AAA domain PNP_UDP_1 PF01048.20 EEA23838.1 - 1.3e-05 24.6 0.2 1.4e-05 24.4 0.2 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily SHR-BD PF06650.12 EEA23839.1 - 0.0075 15.7 0.1 15 4.8 0.0 4.4 1 1 2 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 Phage_Mu_Gp45 PF06890.12 EEA23839.1 - 0.02 14.6 0.1 18 5.2 0.0 3.7 3 2 2 5 5 5 0 Bacteriophage Mu Gp45 protein DUF5619 PF18505.1 EEA23839.1 - 0.12 12.4 2.3 30 4.7 0.1 3.9 1 1 4 5 5 5 0 Domain of unknown function (DUF5619) DUF3328 PF11807.8 EEA23840.1 - 6.7e-62 209.1 0.2 7.8e-62 208.9 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) TMEM208_SND2 PF05620.11 EEA23840.1 - 0.23 11.2 0.1 0.39 10.5 0.1 1.3 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DDE_1 PF03184.19 EEA23841.1 - 1.7e-22 79.9 0.0 3.6e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA23841.1 - 9e-09 35.2 0.3 3.1e-08 33.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA23841.1 - 0.023 14.8 0.1 0.52 10.5 0.0 2.7 3 0 0 3 3 3 0 Transcription factor Pcc1 Amidase PF01425.21 EEA23841.1 - 0.064 12.2 1.4 0.098 11.6 1.4 1.2 1 0 0 1 1 1 0 Amidase Aminotran_3 PF00202.21 EEA23842.1 - 1.6e-51 175.2 0.7 6.2e-50 170.0 0.3 2.9 2 1 0 2 2 2 1 Aminotransferase class-III DegT_DnrJ_EryC1 PF01041.17 EEA23842.1 - 0.00039 19.8 0.0 0.00086 18.7 0.0 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family MFS_1 PF07690.16 EEA23843.1 - 3.7e-26 91.9 46.5 3.7e-26 91.9 46.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pyridoxal_deC PF00282.19 EEA23844.1 - 7e-26 90.8 0.0 1.5e-25 89.8 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EEA23844.1 - 0.0042 16.4 0.0 0.0051 16.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase RTP1_C1 PF10363.9 EEA23844.1 - 0.019 15.1 0.0 0.053 13.7 0.0 1.7 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 Aminotran_1_2 PF00155.21 EEA23844.1 - 0.21 10.7 0.0 0.35 10.0 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II AAA_23 PF13476.6 EEA23845.1 - 0.14 12.6 2.3 0.25 11.8 2.3 1.3 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 EEA23846.1 - 1.6e-07 30.9 0.2 2.2e-07 30.5 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23846.1 - 0.011 15.1 0.3 0.015 14.6 0.3 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DUF3723 PF12520.8 EEA23847.1 - 8.1e-194 645.0 0.2 1.2e-193 644.5 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) DUF2786 PF10979.8 EEA23848.1 - 8.6e-12 44.8 0.0 8.6e-12 44.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) Asp PF00026.23 EEA23849.1 - 1.9e-15 57.1 1.5 3e-15 56.5 1.5 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease zf-C3HC4_3 PF13920.6 EEA23850.1 - 4.2e-05 23.3 12.9 7.3e-05 22.6 12.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HIP1_clath_bdg PF16515.5 EEA23850.1 - 0.015 15.8 5.3 0.015 15.8 5.3 2.1 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0242 PF06785.11 EEA23850.1 - 0.022 14.9 8.5 0.034 14.3 8.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Prok-RING_4 PF14447.6 EEA23850.1 - 0.028 14.3 14.3 0.057 13.3 14.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 V_ATPase_I PF01496.19 EEA23850.1 - 0.047 11.6 0.4 0.054 11.4 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATG16 PF08614.11 EEA23850.1 - 0.055 13.7 10.0 0.097 12.9 10.0 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) zf-RING_2 PF13639.6 EEA23850.1 - 0.074 13.4 12.5 0.19 12.1 12.5 1.8 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 EEA23850.1 - 0.076 12.9 13.0 0.21 11.5 13.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF641 PF04859.12 EEA23850.1 - 0.15 12.4 2.5 0.33 11.3 2.5 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) APG6_N PF17675.1 EEA23850.1 - 0.18 12.3 12.8 0.32 11.5 12.8 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region AAA_lid_9 PF17871.1 EEA23850.1 - 0.18 11.7 2.6 0.24 11.4 0.5 2.0 2 0 0 2 2 2 0 AAA lid domain DUF4407 PF14362.6 EEA23850.1 - 0.2 11.0 9.6 0.41 10.0 8.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DHR10 PF18595.1 EEA23850.1 - 0.23 11.5 11.1 0.43 10.6 11.1 1.4 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain zf-C3HC4_4 PF15227.6 EEA23850.1 - 0.44 10.7 15.2 0.14 12.3 11.5 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF4140 PF13600.6 EEA23850.1 - 0.78 10.2 5.5 0.31 11.5 2.5 2.1 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2968 PF11180.8 EEA23850.1 - 0.92 9.1 11.8 3.2 7.4 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) TMF_TATA_bd PF12325.8 EEA23850.1 - 1.2 9.3 9.3 1.3 9.2 5.5 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding zf-RING_6 PF14835.6 EEA23850.1 - 1.3 8.9 11.7 0.9 9.5 9.5 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Bap31_Bap29_C PF18035.1 EEA23850.1 - 1.9 8.5 5.0 22 5.1 5.0 2.4 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain zf-RING_5 PF14634.6 EEA23850.1 - 3.6 7.6 14.3 11 6.1 14.3 1.9 1 1 0 1 1 1 0 zinc-RING finger domain adh_short_C2 PF13561.6 EEA23851.1 - 1.4e-56 191.7 0.0 2e-56 191.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA23851.1 - 2.8e-39 134.6 0.1 4.1e-39 134.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA23851.1 - 1.2e-12 48.1 0.1 2e-12 47.4 0.1 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EEA23851.1 - 0.0033 16.9 0.1 0.5 9.7 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EEA23851.1 - 0.0069 15.9 0.1 0.016 14.6 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family CPSase_L_D2 PF02786.17 EEA23852.1 - 1.3e-72 243.8 0.0 2e-72 243.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EEA23852.1 - 1.6e-36 125.2 0.0 3.7e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EEA23852.1 - 3.8e-36 123.5 0.0 9.1e-36 122.2 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EEA23852.1 - 1.6e-17 63.1 1.0 1.2e-16 60.2 0.2 2.7 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EEA23852.1 - 1e-09 38.2 0.0 2.5e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EEA23852.1 - 4.9e-09 36.0 0.0 9.8e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EEA23852.1 - 9.5e-05 22.5 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EEA23852.1 - 0.00019 21.2 0.0 0.0081 16.0 0.0 2.8 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 EEA23852.1 - 0.0021 17.9 0.1 0.0074 16.2 0.0 1.8 2 0 0 2 2 2 1 Glycine cleavage H-protein HlyD_3 PF13437.6 EEA23852.1 - 0.0037 17.9 0.0 3.6 8.3 0.0 2.7 2 0 0 2 2 2 1 HlyD family secretion protein GARS_A PF01071.19 EEA23852.1 - 0.0055 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 EEA23852.1 - 0.014 14.7 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp RimK PF08443.11 EEA23852.1 - 0.015 14.9 0.0 0.12 12.0 0.0 2.3 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Capsid_VP7 PF17071.5 EEA23852.1 - 0.018 14.3 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Outer capsid protein VP7 ATP-grasp_4 PF13535.6 EEA23852.1 - 0.03 13.9 0.0 0.078 12.6 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain HlyD_D23 PF16576.5 EEA23852.1 - 0.092 11.9 0.0 6.6 5.9 0.0 2.6 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion PBP1_TM PF14812.6 EEA23853.1 - 0.11 12.9 0.3 0.11 12.9 0.3 4.3 4 1 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1752 PF08550.10 EEA23855.1 - 2.2e-07 30.6 0.4 2.2e-07 30.6 0.4 2.3 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) MARVEL PF01284.23 EEA23856.1 - 0.39 10.7 10.7 1.3 9.0 10.7 2.0 1 1 0 1 1 1 0 Membrane-associating domain Spem1 PF15670.5 EEA23857.1 - 0.11 12.1 2.3 0.31 10.6 2.3 1.7 1 0 0 1 1 1 0 Spermatid maturation protein 1 NDUFB11 PF17250.2 EEA23857.1 - 3.6 8.3 5.4 2.5 8.8 0.1 3.0 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase 11 kDa subunit PHD PF00628.29 EEA23858.1 - 1.6e-09 37.5 1.8 3.7e-09 36.3 1.8 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EEA23858.1 - 0.0089 15.6 2.3 0.015 14.9 2.3 1.4 1 0 0 1 1 1 1 PHD-finger UIM PF02809.20 EEA23858.1 - 0.13 12.3 4.1 0.57 10.2 4.1 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif MFS_1 PF07690.16 EEA23859.1 - 6.8e-40 137.1 32.9 7.8e-40 136.9 32.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3390 PF11870.8 EEA23859.1 - 0.02 15.3 0.1 0.044 14.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3390) eIF-5a PF01287.20 EEA23860.1 - 6e-07 29.5 0.0 1.4e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold adh_short PF00106.25 EEA23861.1 - 1.9e-36 125.3 0.1 6.1e-36 123.7 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23861.1 - 5.7e-26 91.5 0.0 9.4e-26 90.8 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23861.1 - 2.7e-10 40.5 0.0 3.4e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EEA23861.1 - 0.00037 20.8 0.0 0.0022 18.3 0.1 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EEA23861.1 - 0.0025 17.7 0.0 0.0044 16.9 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA23861.1 - 0.0079 15.7 0.0 0.01 15.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Abhydrolase_6 PF12697.7 EEA23863.1 - 9.4e-17 62.4 4.1 1.9e-15 58.0 4.1 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA23863.1 - 2.2e-13 50.5 0.1 1.2e-12 48.1 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA23863.1 - 4.5e-06 26.1 0.0 1.4e-05 24.5 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 stn_TNFRSF12A PF12191.8 EEA23864.1 - 0.14 12.4 0.1 7 6.9 0.0 2.3 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain SRR1 PF07985.12 EEA23865.1 - 1.9e-18 66.2 0.0 3.4e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 SRR1 RRP7 PF12923.7 EEA23865.1 - 0.16 12.1 0.1 0.16 12.1 0.1 2.0 3 0 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Ank_2 PF12796.7 EEA23866.1 - 1.1e-71 237.4 14.8 1.6e-10 41.4 0.2 10.5 8 2 2 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA23866.1 - 6.1e-60 198.9 20.4 1.8e-09 37.9 0.0 16.0 7 3 11 18 18 18 15 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA23866.1 - 2.1e-48 156.7 26.3 0.001 19.4 0.0 19.7 20 0 0 20 20 20 11 Ankyrin repeat Ank PF00023.30 EEA23866.1 - 3.4e-41 137.9 35.7 0.0065 16.9 0.0 18.3 17 1 0 17 17 17 11 Ankyrin repeat Ank_5 PF13857.6 EEA23866.1 - 4.3e-31 106.6 22.4 0.0031 17.8 0.2 14.3 7 3 8 15 15 15 11 Ankyrin repeats (many copies) Clr5 PF14420.6 EEA23866.1 - 2.3e-17 62.9 0.9 4.8e-17 61.9 0.9 1.6 1 0 0 1 1 1 1 Clr5 domain Glyco_hydro_17 PF00332.18 EEA23867.1 - 3.4e-09 36.7 2.5 1.6e-05 24.7 0.4 2.3 1 1 0 2 2 2 2 Glycosyl hydrolases family 17 SP_C-Propep PF08999.10 EEA23867.1 - 0.01 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Romo1 PF10247.9 EEA23867.1 - 2.8 8.4 5.2 14 6.1 0.4 2.8 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 DHHC PF01529.20 EEA23871.1 - 6.3e-25 87.8 5.3 1.2e-24 86.9 2.0 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4131 PF13567.6 EEA23871.1 - 0.33 10.6 3.3 0.19 11.4 1.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Phage_holin_3_6 PF07332.11 EEA23871.1 - 3.2 7.8 5.7 1.3 9.0 2.1 1.9 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Vac14_Fig4_bd PF11916.8 EEA23872.1 - 2.5e-81 271.6 8.3 2.5e-81 271.6 8.3 1.7 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EEA23872.1 - 9.1e-44 148.0 0.0 1.2e-41 141.2 0.0 3.6 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EEA23872.1 - 5.6e-09 36.3 2.0 0.0057 17.1 0.0 5.5 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.22 EEA23872.1 - 1.4e-07 31.1 0.4 0.001 19.1 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EEA23872.1 - 7.9e-05 22.7 0.5 0.1 12.6 0.2 3.4 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA23872.1 - 0.00021 21.6 0.7 0.99 9.8 0.0 5.0 5 2 0 5 5 5 1 HEAT repeats DUF3385 PF11865.8 EEA23872.1 - 0.0015 18.5 0.0 1.1 9.1 0.0 3.9 3 1 0 3 3 3 1 Domain of unknown function (DUF3385) Arm PF00514.23 EEA23872.1 - 0.019 15.0 0.0 15 5.8 0.0 4.7 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Paramyxo_C PF01692.18 EEA23872.1 - 0.039 13.3 0.1 0.12 11.7 0.1 1.8 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C Activator-TraM PF11657.8 EEA23872.1 - 0.22 11.3 1.4 0.9 9.4 1.4 2.0 1 0 0 1 1 1 0 Transcriptional activator TraM SNF2_N PF00176.23 EEA23873.1 - 4.6e-58 196.6 0.0 7.2e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EEA23873.1 - 3.7e-57 193.4 0.6 1e-55 188.7 0.4 2.3 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 EEA23873.1 - 4e-16 59.4 0.0 1.1e-15 58.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA23873.1 - 1.6e-08 34.8 0.0 2.9e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EEA23873.1 - 0.0011 18.2 0.0 0.0054 15.9 0.0 2.0 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Mito_carr PF00153.27 EEA23874.1 - 4.2e-50 167.6 2.3 2.9e-19 68.8 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein zf-C2H2_jaz PF12171.8 EEA23876.1 - 2.9e-10 40.2 4.5 2.9e-10 40.2 4.5 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-SCNM1 PF15803.5 EEA23876.1 - 0.037 13.7 0.3 0.037 13.7 0.3 1.6 2 0 0 2 2 2 0 Zinc-finger of sodium channel modifier 1 TEX13 PF15186.6 EEA23876.1 - 0.13 11.9 0.2 0.13 11.9 0.2 1.6 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family zf-C2H2_2 PF12756.7 EEA23876.1 - 0.18 12.1 4.0 0.54 10.6 4.0 1.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EEA23876.1 - 0.28 11.2 2.7 0.52 10.4 2.7 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EEA23876.1 - 0.32 12.0 3.3 0.24 12.3 1.5 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger Aconitase PF00330.20 EEA23877.1 - 3.9e-152 507.5 0.0 4.7e-152 507.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EEA23877.1 - 7.7e-45 152.4 0.0 1.3e-44 151.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain BLACT_WH PF17778.1 EEA23878.1 - 3.7e-19 68.4 0.4 1.2e-18 66.9 0.1 2.0 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 EEA23878.1 - 7.4e-15 55.5 3.9 9.4e-13 48.6 3.9 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA23878.1 - 3e-06 26.9 1.4 1.1e-05 25.1 1.4 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Glyco_transf_20 PF00982.21 EEA23879.1 - 8.9e-199 661.0 0.0 1e-198 660.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EEA23879.1 - 0.032 13.9 0.3 0.07 12.8 0.1 1.7 2 0 0 2 2 2 0 Starch synthase catalytic domain Ribosomal_S17 PF00366.20 EEA23880.1 - 7.5e-16 58.0 1.5 1e-15 57.6 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein S17 AAA PF00004.29 EEA23881.1 - 1.3e-37 129.2 0.0 2.6e-37 128.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EEA23881.1 - 3.3e-08 33.4 0.1 6.4e-07 29.3 0.0 3.1 4 0 0 4 4 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EEA23881.1 - 3.6e-07 29.9 0.0 7.8e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EEA23881.1 - 4.1e-05 23.9 0.2 0.0017 18.6 0.0 2.6 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EEA23881.1 - 6.8e-05 22.7 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EEA23881.1 - 0.00015 21.9 0.0 0.00041 20.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA23881.1 - 0.00041 20.8 1.3 0.0037 17.7 0.1 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EEA23881.1 - 0.0012 18.8 0.0 0.0031 17.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EEA23881.1 - 0.003 16.8 0.0 0.0051 16.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EEA23881.1 - 0.0043 16.8 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EEA23881.1 - 0.0045 16.4 0.1 0.0099 15.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EEA23881.1 - 0.01 16.0 0.0 0.023 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EEA23881.1 - 0.013 14.6 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 EEA23881.1 - 0.062 12.9 0.0 0.18 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EEA23881.1 - 0.076 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EEA23881.1 - 0.086 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA23881.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EEA23881.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EEA23881.1 - 0.13 12.0 0.0 0.41 10.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.6 EEA23881.1 - 0.13 12.8 0.0 0.36 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EEA23881.1 - 0.19 12.0 0.6 0.72 10.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain Ntox28 PF15605.6 EEA23881.1 - 0.69 10.2 4.5 0.49 10.7 0.1 2.4 2 0 0 2 2 2 0 Bacterial toxin 28 Mito_carr PF00153.27 EEA23882.1 - 6.4e-65 215.1 5.0 1e-22 79.8 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA23882.1 - 0.0086 15.3 1.6 0.19 10.9 0.1 3.0 2 1 2 4 4 4 1 Gammaproteobacterial serine protease IBR PF01485.21 EEA23883.1 - 1.6e-21 76.2 47.0 2.3e-12 46.9 5.6 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EEA23883.1 - 5e-06 26.3 39.8 0.00032 20.5 6.3 4.4 3 1 1 4 4 4 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA23883.1 - 0.0001 22.5 44.8 0.0004 20.6 10.2 3.7 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 EEA23883.1 - 0.00065 19.5 44.9 0.00066 19.5 6.8 4.9 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA23883.1 - 0.0063 16.4 11.2 0.0063 16.4 11.2 3.7 3 0 0 3 3 3 1 zinc-RING finger domain UN_NPL4 PF11543.8 EEA23883.1 - 0.0071 16.8 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-RING_UBOX PF13445.6 EEA23883.1 - 0.016 15.2 5.4 0.016 15.2 5.4 4.0 3 1 0 3 3 3 0 RING-type zinc-finger Trp_syntA PF00290.20 EEA23883.1 - 0.084 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Tryptophan synthase alpha chain IBR PF01485.21 EEA23884.1 - 1.9e-21 76.0 47.0 2.5e-12 46.8 5.6 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EEA23884.1 - 4.4e-06 26.5 39.4 0.00034 20.4 6.3 4.3 3 1 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA23884.1 - 0.00012 22.3 44.8 0.00042 20.6 10.2 3.7 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 EEA23884.1 - 0.0007 19.4 6.8 0.0007 19.4 6.8 4.9 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA23884.1 - 0.0066 16.4 11.2 0.0066 16.4 11.2 3.7 3 0 0 3 3 3 2 zinc-RING finger domain UN_NPL4 PF11543.8 EEA23884.1 - 0.0075 16.7 0.0 0.016 15.7 0.0 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-RING_UBOX PF13445.6 EEA23884.1 - 0.017 15.1 5.4 0.017 15.1 5.4 4.0 3 1 0 3 3 3 0 RING-type zinc-finger Trp_syntA PF00290.20 EEA23884.1 - 0.088 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Tryptophan synthase alpha chain Methyltransf_2 PF00891.18 EEA23886.1 - 8.9e-21 74.2 0.0 1.8e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EEA23886.1 - 0.00083 20.0 0.0 0.003 18.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA23886.1 - 0.0021 17.9 0.0 0.0042 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA23886.1 - 0.22 10.8 0.0 0.78 9.0 0.0 1.8 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF3328 PF11807.8 EEA23887.1 - 1.3e-24 87.2 6.4 1.2e-23 84.1 6.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EEA23888.1 - 4.1e-38 131.3 0.0 5e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) BCD PF15461.6 EEA23888.1 - 0.16 11.5 0.2 0.22 11.0 0.2 1.2 1 0 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase ECSCR PF15820.5 EEA23889.1 - 0.22 11.4 0.7 1.4 8.8 0.1 2.4 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator W2 PF02020.18 EEA23890.1 - 1.1e-20 73.6 6.5 1.1e-20 73.6 6.5 2.6 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 EEA23890.1 - 2.2e-12 46.2 22.3 2.1e-06 27.2 0.5 3.9 1 1 4 5 5 5 5 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 EEA23890.1 - 1.8e-05 24.4 0.0 3.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 EEA23890.1 - 0.00045 19.9 12.8 0.34 10.7 1.0 3.9 1 1 3 4 4 4 4 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.7 EEA23890.1 - 0.0072 16.7 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EEA23890.1 - 0.011 13.9 1.4 0.13 10.4 1.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) HSF_DNA-bind PF00447.17 EEA23891.1 - 4.6e-31 107.3 1.9 4.6e-31 107.3 1.9 2.1 2 0 0 2 2 2 1 HSF-type DNA-binding Response_reg PF00072.24 EEA23891.1 - 2.9e-23 82.2 0.1 6.8e-23 81.0 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Ets PF00178.22 EEA23891.1 - 0.057 13.9 0.4 0.2 12.1 0.1 2.1 2 0 0 2 2 2 0 Ets-domain Abhydrolase_6 PF12697.7 EEA23893.1 - 5.7e-13 50.0 0.1 6.9e-13 49.7 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA23893.1 - 4.6e-11 42.9 0.0 1.5e-10 41.2 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA23893.1 - 8.8e-09 35.0 0.0 1.7e-08 34.1 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EEA23893.1 - 6.1e-07 29.5 0.0 9.5e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EEA23893.1 - 5e-05 23.2 0.0 7.4e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase DUF900 PF05990.12 EEA23893.1 - 0.00028 20.5 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 EEA23893.1 - 0.00072 19.2 0.0 0.00093 18.8 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Thioesterase PF00975.20 EEA23893.1 - 0.0013 18.9 0.0 0.0031 17.7 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain PGAP1 PF07819.13 EEA23893.1 - 0.0027 17.5 0.0 0.0039 16.9 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_2 PF02230.16 EEA23893.1 - 0.008 16.0 0.0 0.056 13.2 0.0 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase LCAT PF02450.15 EEA23893.1 - 0.039 13.1 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Cutinase PF01083.22 EEA23893.1 - 0.064 13.2 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Cutinase DUF726 PF05277.12 EEA23893.1 - 0.072 12.0 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF2974 PF11187.8 EEA23893.1 - 0.086 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 EEA23893.1 - 0.099 12.5 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 EEA23893.1 - 0.13 11.9 3.8 0.24 11.0 0.4 2.1 1 1 1 2 2 2 0 Putative esterase GST_N_4 PF17172.4 EEA23894.1 - 2.3e-17 63.5 0.0 4.9e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EEA23894.1 - 1.1e-05 25.1 0.0 0.0015 18.3 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain WSC PF01822.19 EEA23895.1 - 3.6e-09 36.7 11.3 3.6e-09 36.7 11.3 2.0 2 0 0 2 2 2 1 WSC domain VSP PF03302.13 EEA23895.1 - 0.032 13.1 31.1 0.077 11.8 31.1 1.6 1 1 0 1 1 1 0 Giardia variant-specific surface protein Podoplanin PF05808.11 EEA23895.1 - 0.95 9.6 17.6 0.49 10.5 15.0 1.8 2 0 0 2 2 2 0 Podoplanin DUF4690 PF15756.5 EEA23895.1 - 4.1 8.1 18.0 0.12 12.9 6.7 2.9 2 1 1 3 3 3 0 Small Novel Rich in Cartilage BTB PF00651.31 EEA23896.1 - 2.6e-11 43.8 1.1 7.7e-11 42.2 0.0 2.3 3 0 0 3 3 3 1 BTB/POZ domain TPR_MLP1_2 PF07926.12 EEA23896.1 - 0.089 12.9 1.8 0.22 11.6 1.8 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein zinc_ribbon_4 PF13717.6 EEA23896.1 - 0.11 12.5 1.0 8.4 6.4 0.0 2.6 2 0 0 2 2 2 0 zinc-ribbon domain DUF4391 PF14335.6 EEA23896.1 - 0.11 12.2 1.1 0.19 11.4 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) NYD-SP28_assoc PF14775.6 EEA23896.1 - 0.14 12.3 0.3 0.39 10.9 0.3 1.7 1 0 0 1 1 1 0 Sperm tail C-terminal domain Cytochrome_C7 PF14522.6 EEA23896.1 - 0.81 9.7 4.2 4.3 7.4 4.2 2.2 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c GLYCAM-1 PF05242.11 EEA23898.1 - 3.5 7.8 7.5 0.59 10.3 0.2 3.3 3 1 1 4 4 4 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) IMS PF00817.20 EEA23899.1 - 1.6e-35 122.3 0.0 5.9e-34 117.2 0.0 2.4 1 1 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EEA23899.1 - 3.2e-14 53.6 0.0 8e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 EEA23899.1 - 4.2e-13 48.6 4.6 8.5e-13 47.7 4.6 1.5 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 EEA23899.1 - 0.074 13.4 0.1 0.17 12.3 0.1 1.7 1 0 0 1 1 1 0 IMS family HHH motif PhyH PF05721.13 EEA23900.1 - 0.05 13.9 0.0 0.06 13.6 0.0 1.2 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) Retinal PF15449.6 EEA23901.1 - 2.9 5.6 14.2 3.3 5.4 14.2 1.0 1 0 0 1 1 1 0 Retinal protein Mg_chelatase_C PF13335.6 EEA23902.1 - 0.013 16.1 0.0 0.028 15.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal NADHdh_A3 PF14987.6 EEA23903.1 - 0.1 12.9 0.1 0.13 12.6 0.1 1.1 1 0 0 1 1 1 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 DDOST_48kD PF03345.14 EEA23904.1 - 5.4e-156 519.6 0.0 6.2e-156 519.4 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Pet191_N PF10203.9 EEA23905.1 - 8.1e-27 93.3 4.6 1e-26 93.0 4.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COBRA PF04833.15 EEA23905.1 - 0.0041 17.0 0.2 0.0044 16.9 0.2 1.1 1 0 0 1 1 1 1 COBRA-like protein Cmc1 PF08583.10 EEA23905.1 - 0.019 15.0 2.4 3.6 7.7 0.3 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like PAN_3 PF08277.12 EEA23905.1 - 0.055 13.3 0.4 0.11 12.3 0.4 1.5 1 0 0 1 1 1 0 PAN-like domain Hs1pro-1_C PF07014.12 EEA23905.1 - 0.21 11.0 0.0 0.25 10.8 0.0 1.1 1 0 0 1 1 1 0 Hs1pro-1 protein C-terminus CX9C PF16860.5 EEA23905.1 - 0.95 9.5 9.3 6.1 6.9 0.2 3.0 1 1 2 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 EEA23906.1 - 1.4e-15 57.3 0.6 1.8e-15 57.0 0.6 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Hs1pro-1_C PF07014.12 EEA23906.1 - 0.17 11.3 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 Hs1pro-1 protein C-terminus Pro-kuma_activ PF09286.11 EEA23907.1 - 6.9e-32 110.7 0.2 1.4e-31 109.7 0.1 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Abhydrolase_1 PF00561.20 EEA23908.1 - 3.1e-26 92.6 0.0 3.9e-25 89.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EEA23908.1 - 2.1e-23 81.7 0.1 4.1e-23 80.7 0.1 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EEA23908.1 - 8.2e-05 22.0 0.0 0.012 14.9 0.0 2.4 2 1 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EEA23908.1 - 0.0014 18.4 0.1 0.046 13.4 0.0 2.4 3 0 0 3 3 3 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EEA23909.1 - 2.2e-22 80.0 0.0 3.3e-21 76.1 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA23909.1 - 8.1e-05 22.0 0.0 0.019 14.3 0.0 2.4 2 1 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EEA23909.1 - 0.00081 19.1 0.0 0.026 14.2 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase (FSH1) EXS PF03124.14 EEA23911.1 - 8.2e-99 331.0 36.8 1e-98 330.7 36.8 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EEA23911.1 - 1.4e-81 275.4 8.8 1.4e-81 275.4 8.8 2.0 2 0 0 2 2 2 1 SPX domain Bax1-I PF01027.20 EEA23912.1 - 8.1e-54 182.6 28.6 9.3e-54 182.4 28.6 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF5504 PF17608.2 EEA23912.1 - 0.0092 16.1 6.1 0.0092 16.1 6.1 2.1 1 1 1 2 2 2 1 Family of unknown function (DUF5504) DUF2070 PF09843.9 EEA23912.1 - 8.3 4.6 21.3 11 4.2 21.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Aa_trans PF01490.18 EEA23913.1 - 6.5e-94 314.9 17.6 6.5e-94 314.9 17.6 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EEA23913.1 - 8.8e-06 25.0 21.1 8.8e-06 25.0 21.1 1.5 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family ORMDL PF04061.14 EEA23913.1 - 4.3 7.1 7.7 0.22 11.3 0.3 2.5 2 1 1 3 3 3 0 ORMDL family adh_short PF00106.25 EEA23914.1 - 8.2e-38 129.8 0.0 1e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA23914.1 - 5.6e-29 101.4 0.0 8.6e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA23914.1 - 0.00024 21.1 0.0 0.0032 17.4 0.0 2.0 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 EEA23914.1 - 0.16 11.3 0.1 0.23 10.8 0.1 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) EMC1_C PF07774.13 EEA23915.1 - 1.2e-73 247.3 0.0 2e-73 246.6 0.0 1.4 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EEA23915.1 - 4.4e-35 121.4 7.4 1.9e-31 109.5 1.9 2.5 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 EEA23915.1 - 1.8e-06 27.6 8.9 0.01 15.8 0.0 6.3 7 0 0 7 7 7 2 PQQ enzyme repeat Peptidase_S8 PF00082.22 EEA23916.1 - 1.3e-35 123.1 12.3 2e-35 122.5 11.7 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EEA23916.1 - 1.5e-20 73.6 0.2 4e-20 72.3 0.2 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 TgMIC1 PF11476.8 EEA23916.1 - 0.022 14.5 1.4 0.057 13.2 0.0 2.2 2 0 0 2 2 2 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Beach PF02138.18 EEA23917.1 - 1.5e-118 395.2 0.0 2.6e-118 394.4 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EEA23917.1 - 2e-11 43.9 0.2 2e-11 43.9 0.2 2.0 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EEA23917.1 - 4.9e-08 33.3 0.0 1.1e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 EEA23917.1 - 2.9e-05 24.7 5.1 0.086 13.7 0.1 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF4704 PF15787.5 EEA23917.1 - 3.7e-05 23.1 0.0 0.025 13.8 0.0 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF4704) TAL_FSA PF00923.19 EEA23918.1 - 1.2e-94 316.9 0.0 1.3e-94 316.7 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Sod_Cu PF00080.20 EEA23919.1 - 1.8e-46 157.8 4.3 2.1e-46 157.6 4.3 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) SNase PF00565.17 EEA23920.1 - 2.4e-78 259.6 0.9 1.3e-25 89.9 0.0 5.5 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EEA23920.1 - 8.8e-25 87.1 0.0 1.9e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 EEA23920.1 - 4.6e-06 26.1 0.0 1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Agenet PF05641.12 EEA23920.1 - 0.0027 18.1 0.3 0.022 15.2 0.1 2.7 2 0 0 2 2 2 1 Agenet domain CRAL_TRIO PF00650.20 EEA23921.1 - 8.1e-26 90.6 0.0 1.1e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA23921.1 - 4e-11 42.9 0.0 9.3e-11 41.7 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain UQ_con PF00179.26 EEA23922.1 - 1.5e-38 131.6 0.0 2e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA23922.1 - 0.027 14.8 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 RWD domain NOA36 PF06524.12 EEA23922.1 - 5.2 6.3 14.7 6.5 6.0 14.7 1.1 1 0 0 1 1 1 0 NOA36 protein ABC_tran PF00005.27 EEA23923.1 - 3.5e-55 186.3 0.0 1.7e-32 112.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA23923.1 - 8.5e-51 173.2 25.8 8.6e-33 114.2 9.9 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA23923.1 - 6.3e-08 32.3 4.4 0.0068 15.9 0.0 4.5 3 2 2 5 5 5 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EEA23923.1 - 1.3e-06 28.4 0.0 0.047 13.8 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EEA23923.1 - 2.5e-06 28.1 2.0 0.0016 19.0 0.1 2.8 3 0 0 3 3 2 2 AAA domain AAA_21 PF13304.6 EEA23923.1 - 6.7e-06 26.1 3.4 0.029 14.2 0.2 3.5 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA23923.1 - 7.4e-05 22.7 0.2 0.11 12.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EEA23923.1 - 0.00032 21.1 1.9 0.61 10.4 0.1 3.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA23923.1 - 0.00071 19.9 2.1 8 6.7 0.0 3.7 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EEA23923.1 - 0.00071 19.3 1.0 0.65 9.8 0.1 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EEA23923.1 - 0.0023 17.7 1.2 0.27 11.0 0.0 3.0 3 0 0 3 3 2 1 IstB-like ATP binding protein T2SSE PF00437.20 EEA23923.1 - 0.0068 15.5 0.2 0.033 13.2 0.1 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_15 PF13175.6 EEA23923.1 - 0.0097 15.6 0.0 0.51 10.0 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EEA23923.1 - 0.057 12.9 0.2 11 5.5 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 EEA23923.1 - 0.057 13.5 5.7 0.43 10.6 0.4 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_18 PF13238.6 EEA23923.1 - 0.062 13.8 0.3 13 6.3 0.0 3.2 3 0 0 3 3 2 0 AAA domain AAA PF00004.29 EEA23923.1 - 0.071 13.5 1.4 6.9 7.1 0.1 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.7 EEA23923.1 - 0.08 11.9 0.0 0.64 8.9 0.0 2.3 3 0 0 3 3 3 0 AAA-like domain DEAD PF00270.29 EEA23923.1 - 0.091 12.5 0.5 17 5.1 0.0 3.0 2 1 0 2 2 2 0 DEAD/DEAH box helicase cobW PF02492.19 EEA23923.1 - 0.1 12.2 0.8 0.34 10.5 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Guanylate_kin PF00625.21 EEA23923.1 - 0.18 11.5 0.7 1 9.0 0.0 2.4 3 0 0 3 3 2 0 Guanylate kinase Zeta_toxin PF06414.12 EEA23923.1 - 0.2 10.9 1.3 5.9 6.1 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin Roc PF08477.13 EEA23923.1 - 0.22 11.7 0.7 12 6.1 0.1 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EEA23923.1 - 0.24 11.1 0.7 16 5.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 EEA23923.1 - 0.45 10.5 2.0 19 5.3 0.0 3.0 3 0 0 3 3 2 0 Dynamin family NACHT PF05729.12 EEA23923.1 - 0.46 10.4 2.2 3.1 7.7 0.2 2.6 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EEA23923.1 - 0.54 9.8 5.6 3 7.4 0.1 2.8 3 0 0 3 3 2 0 AAA domain AAA_12 PF13087.6 EEA23924.1 - 3e-35 121.7 0.1 4.9e-35 121.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EEA23924.1 - 6.2e-23 81.9 0.0 2.1e-21 76.9 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA23924.1 - 2.7e-09 37.0 0.0 6e-07 29.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EEA23924.1 - 9.6e-08 32.5 0.0 4e-06 27.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EEA23924.1 - 2.3e-05 24.5 0.0 6.5e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA23924.1 - 0.001 18.9 0.0 0.0033 17.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 EEA23924.1 - 0.0011 18.8 0.0 0.12 12.1 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EEA23924.1 - 0.0047 16.4 0.0 0.023 14.2 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein UvrD-helicase PF00580.21 EEA23924.1 - 0.023 14.2 0.0 0.38 10.2 0.0 2.7 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 EEA23924.1 - 0.038 13.2 0.0 0.75 9.0 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) WD40 PF00400.32 EEA23925.1 - 7.6e-16 58.2 0.0 0.01 16.7 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA23925.1 - 0.00036 20.8 0.1 19 5.6 0.0 4.8 3 2 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain CDV3 PF15359.6 EEA23925.1 - 1.3 9.6 16.5 0.33 11.4 5.0 2.3 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Nop14 PF04147.12 EEA23925.1 - 4.4 5.4 12.8 6.1 4.9 12.8 1.1 1 0 0 1 1 1 0 Nop14-like family PRP38 PF03371.15 EEA23927.1 - 1.4e-62 210.6 0.0 1.8e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 PRP38 family Tnp_22_trimer PF17489.2 EEA23927.1 - 0.0021 18.0 0.4 0.0041 17.0 0.4 1.4 1 0 0 1 1 1 1 L1 transposable element trimerization domain HetR_C PF18460.1 EEA23927.1 - 0.093 12.7 0.5 0.21 11.5 0.5 1.5 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain Integrase_H2C2 PF17921.1 EEA23927.1 - 0.2 11.8 0.3 3.1 8.0 0.0 2.2 2 0 0 2 2 2 0 Integrase zinc binding domain DUF3445 PF11927.8 EEA23928.1 - 8.5e-76 254.5 0.0 1.1e-75 254.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Ank_2 PF12796.7 EEA23929.1 - 4.6e-45 152.1 10.8 1.7e-15 57.3 0.1 4.6 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA23929.1 - 6.9e-38 128.5 6.4 1.1e-08 35.4 0.2 8.0 2 1 5 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 EEA23929.1 - 8.9e-28 95.5 15.8 2e-06 28.0 0.2 9.2 9 0 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 EEA23929.1 - 2.2e-23 79.8 6.0 0.02 15.4 0.1 9.4 10 0 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 EEA23929.1 - 7.9e-23 80.2 12.1 0.0079 16.5 0.0 7.4 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Bro-N PF02498.17 EEA23929.1 - 0.14 12.9 0.0 0.45 11.2 0.0 1.8 2 0 0 2 2 2 0 BRO family, N-terminal domain RdRP PF05183.12 EEA23930.1 - 3.7e-133 445.2 0.0 4.9e-133 444.9 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Opi1 PF08618.10 EEA23932.1 - 2.4e-45 155.6 14.3 9e-34 117.4 3.8 3.3 1 1 1 3 3 3 3 Transcription factor Opi1 adh_short_C2 PF13561.6 EEA23934.1 - 6.6e-53 179.7 0.5 1.4e-52 178.6 0.5 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA23934.1 - 6.5e-34 117.1 1.1 3.9e-33 114.6 1.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA23934.1 - 9.3e-09 35.4 1.4 1.2e-07 31.8 0.3 2.2 1 1 1 2 2 2 1 KR domain F420_oxidored PF03807.17 EEA23934.1 - 0.0027 18.2 1.0 0.0048 17.5 1.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EEA23934.1 - 0.021 14.2 0.1 0.65 9.3 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 EEA23934.1 - 0.078 12.3 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 EEA23934.1 - 0.095 12.2 0.1 0.23 10.9 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EEA23934.1 - 0.12 12.2 0.7 0.19 11.6 0.7 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Voldacs PF03517.13 EEA23936.1 - 1.1e-33 116.2 0.1 1.1e-33 116.2 0.1 1.5 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling PUL PF08324.11 EEA23937.1 - 1.1e-71 241.4 3.0 1.5e-71 240.9 3.0 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 EEA23937.1 - 5e-45 152.4 0.0 1.3e-44 151.1 0.1 1.7 2 0 0 2 2 2 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EEA23937.1 - 5.3e-32 109.4 13.9 7.4e-07 29.8 0.0 8.3 8 0 0 8 8 8 5 WD domain, G-beta repeat INCA1 PF15142.6 EEA23937.1 - 0.13 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 INCA1 Mcl1_mid PF12341.8 EEA23937.1 - 0.2 11.0 0.5 4.5 6.5 0.0 2.9 4 0 0 4 4 4 0 Minichromosome loss protein, Mcl1, middle region YjeF_N PF03853.15 EEA23938.1 - 2.1e-35 122.1 0.0 2.7e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus YjeF_N PF03853.15 EEA23939.1 - 5.2e-34 117.6 0.0 6.3e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus NAD_binding_10 PF13460.6 EEA23939.1 - 0.25 11.2 0.0 0.32 10.9 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding Ribosomal_S16 PF00886.19 EEA23940.1 - 2.7e-26 91.4 0.1 3.9e-26 90.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 RRM_1 PF00076.22 EEA23941.1 - 3.8e-18 65.1 0.1 3.8e-13 49.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA23941.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Bot1p PF12298.8 EEA23942.1 - 2.1e-56 190.8 2.0 2.1e-56 190.8 2.0 1.9 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein DUF501 PF04417.12 EEA23942.1 - 0.019 14.8 0.5 0.04 13.7 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF501) HLH PF00010.26 EEA23943.1 - 2.1e-12 46.8 0.1 3.9e-12 45.9 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DHHW PF14286.6 EEA23943.1 - 0.17 11.2 4.3 0.3 10.3 4.3 1.5 1 0 0 1 1 1 0 DHHW protein Mito_fiss_reg PF05308.11 EEA23943.1 - 0.38 10.8 14.8 0.77 9.8 1.0 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator Macoilin PF09726.9 EEA23943.1 - 2.1 6.8 12.7 3 6.3 12.7 1.2 1 0 0 1 1 1 0 Macoilin family Hamartin PF04388.12 EEA23943.1 - 3.5 6.2 13.0 4.6 5.8 13.0 1.1 1 0 0 1 1 1 0 Hamartin protein DUF4629 PF15442.6 EEA23943.1 - 6.8 6.9 13.8 0.18 12.0 7.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4629) Response_reg PF00072.24 EEA23944.1 - 1e-20 74.0 0.0 1.2e-13 51.2 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain PQ-loop PF04193.14 EEA23945.1 - 4.6e-22 77.5 7.9 1.2e-19 69.8 0.5 3.3 2 1 1 3 3 3 2 PQ loop repeat SH3_1 PF00018.28 EEA23946.1 - 4.8e-11 42.1 0.1 9.9e-11 41.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EEA23946.1 - 3e-07 30.2 0.0 5.7e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EEA23946.1 - 5e-06 26.1 0.0 9.4e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 EEA23946.1 - 0.0036 17.3 0.0 0.0063 16.6 0.0 1.3 1 0 0 1 1 1 1 SH3 domain DUF4203 PF13886.6 EEA23946.1 - 0.094 12.4 11.7 0.13 11.9 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4203) TMEM220 PF15071.6 EEA23946.1 - 0.16 12.7 3.7 0.4 11.4 3.7 1.7 1 1 0 1 1 1 0 Transmembrane family 220, helix EMC3_TMCO1 PF01956.16 EEA23946.1 - 0.23 11.2 2.5 1.9 8.2 1.0 2.3 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF1129 PF06570.11 EEA23946.1 - 2.6 7.5 8.3 1 8.8 5.7 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) Dynactin_p22 PF07426.11 EEA23947.1 - 5.2e-11 42.7 0.0 1e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Dynactin subunit p22 UBA_4 PF14555.6 EEA23947.1 - 2e-10 40.3 0.0 5.7e-10 38.9 0.0 1.9 1 0 0 1 1 1 1 UBA-like domain Tex_N PF09371.10 EEA23947.1 - 0.0037 16.9 2.3 0.035 13.8 2.4 2.4 2 0 0 2 2 2 1 Tex-like protein N-terminal domain AMP-binding PF00501.28 EEA23948.1 - 1.3e-92 310.6 0.0 1.7e-92 310.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA23948.1 - 1.2e-19 71.0 0.0 2.7e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Pkinase PF00069.25 EEA23949.1 - 1.2e-47 162.5 0.0 1.9e-47 161.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23949.1 - 2.1e-27 96.1 0.0 1.2e-26 93.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA23949.1 - 6.9e-05 22.3 0.2 0.00059 19.2 0.2 2.0 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EEA23949.1 - 0.053 13.1 0.6 0.75 9.4 0.0 2.5 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EEA23949.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family M16C_assoc PF08367.11 EEA23949.1 - 0.18 10.9 0.2 0.31 10.1 0.2 1.3 1 0 0 1 1 1 0 Peptidase M16C associated ABM PF03992.16 EEA23950.1 - 0.018 15.1 0.1 0.041 14.0 0.0 1.6 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase DUF2052 PF09747.9 EEA23951.1 - 7.1e-20 72.0 21.5 1.7e-09 38.1 16.1 2.3 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Spermine_synth PF01564.17 EEA23952.1 - 3.9e-07 29.6 0.0 7.4e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 EEA23952.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EEA23952.1 - 0.1 13.4 0.0 0.41 11.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Spermine_synth PF01564.17 EEA23953.1 - 2.5e-07 30.3 0.0 4.2e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 EEA23953.1 - 0.047 13.5 0.0 0.074 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EEA23953.1 - 0.18 12.6 0.0 0.31 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Y_phosphatase3 PF13350.6 EEA23954.1 - 3e-61 207.3 0.0 3.4e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EEA23954.1 - 0.0037 16.8 0.0 0.01 15.4 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EEA23954.1 - 0.0065 16.1 0.0 0.009 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EEA23954.1 - 0.051 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Myotub-related PF06602.14 EEA23954.1 - 0.13 11.1 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DLIC PF05783.11 EEA23955.1 - 8.9e-38 130.3 0.3 9.3e-34 117.1 0.0 3.5 3 1 0 3 3 3 3 Dynein light intermediate chain (DLIC) Urb2 PF10441.9 EEA23955.1 - 0.078 12.9 0.0 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 Urb2/Npa2 family RRM_1 PF00076.22 EEA23956.1 - 4e-20 71.4 0.0 1.2e-19 69.9 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA23956.1 - 1.7e-05 24.8 0.0 5.2e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EEA23956.1 - 0.039 13.5 0.0 0.1 12.2 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EEA23956.1 - 0.12 12.1 0.2 0.54 10.0 0.2 2.3 1 1 0 1 1 1 0 Ribonuclease B OB domain DUF3006 PF11213.8 EEA23956.1 - 0.71 10.1 5.5 10 6.5 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF3006) WD40 PF00400.32 EEA23957.1 - 0.00076 20.2 2.9 0.6 11.1 0.0 3.4 4 0 0 4 4 4 2 WD domain, G-beta repeat IKI3 PF04762.12 EEA23957.1 - 0.0053 14.8 0.0 0.007 14.4 0.0 1.1 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EEA23957.1 - 0.0089 16.3 0.0 0.84 10.0 0.0 3.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA23957.1 - 0.058 12.3 0.1 0.22 10.4 0.0 1.8 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EEA23957.1 - 0.16 11.3 0.0 0.38 10.0 0.0 1.7 1 1 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Septin PF00735.18 EEA23958.1 - 1.9e-108 362.0 0.0 3.4e-108 361.2 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EEA23958.1 - 3.1e-05 24.0 0.0 7.5e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EEA23958.1 - 0.00034 20.7 1.8 0.77 9.8 0.0 3.0 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EEA23958.1 - 0.00047 19.8 0.2 0.037 13.5 0.1 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA23958.1 - 0.0017 18.3 1.9 0.0077 16.2 0.2 2.6 3 1 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 EEA23958.1 - 0.042 13.2 0.0 0.088 12.1 0.0 1.6 1 0 0 1 1 1 0 AIG1 family AAA_33 PF13671.6 EEA23958.1 - 0.052 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA23958.1 - 0.065 13.5 1.6 0.19 12.0 0.1 2.3 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 EEA23958.1 - 0.1 12.8 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase EB1 PF03271.17 EEA23958.1 - 0.11 12.8 1.8 2.8 8.3 1.1 2.6 2 0 0 2 2 2 0 EB1-like C-terminal motif IIGP PF05049.13 EEA23958.1 - 0.13 11.3 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Ribosomal_S17e PF00833.18 EEA23958.1 - 0.65 9.9 4.1 1.4 8.8 4.1 1.5 1 0 0 1 1 1 0 Ribosomal S17 FtsK_SpoIIIE PF01580.18 EEA23958.1 - 0.65 9.3 3.1 0.35 10.2 0.1 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family CNH PF00780.22 EEA23959.1 - 3.5e-80 269.6 0.0 5.6e-78 262.3 0.0 2.2 2 0 0 2 2 2 2 CNH domain PH_5 PF15405.6 EEA23959.1 - 4.6e-42 143.3 0.0 1.2e-41 142.0 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EEA23959.1 - 3.7e-39 134.8 0.0 6.7e-39 134.0 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EEA23959.1 - 7.8e-15 54.7 0.1 2e-14 53.4 0.0 1.8 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ATP-synt_C PF00137.21 EEA23960.1 - 2.7e-28 98.1 33.7 7.8e-17 61.4 12.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C ATP-synt_C PF00137.21 EEA23961.1 - 2.7e-28 98.1 33.7 7.8e-17 61.4 12.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Pkinase PF00069.25 EEA23962.1 - 2.7e-63 213.8 0.0 3.2e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23962.1 - 2.7e-32 112.1 0.0 3.5e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EEA23962.1 - 0.004 16.8 0.0 0.017 14.8 0.0 1.8 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EEA23962.1 - 0.02 14.2 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EEA23962.1 - 0.02 13.8 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Gly_transf_sug PF04488.15 EEA23963.1 - 2.7e-14 53.6 0.0 4.9e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Abhydrolase_1 PF00561.20 EEA23964.1 - 1.3e-45 156.1 0.0 6.3e-45 153.8 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EEA23964.1 - 0.00044 20.0 0.0 0.00091 18.9 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 EEA23964.1 - 0.084 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase ThiF PF00899.21 EEA23965.1 - 5.3e-41 140.6 0.0 8.3e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.18 EEA23965.1 - 0.0022 18.2 0.0 0.027 14.7 0.0 2.5 2 0 0 2 2 2 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EEA23965.1 - 0.0029 17.9 1.6 0.044 14.0 1.6 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EEA23965.1 - 0.036 13.6 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EEA23965.1 - 0.051 14.0 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 EEA23965.1 - 0.079 12.6 0.2 0.17 11.5 0.2 1.7 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF2093 PF09866.9 EEA23965.1 - 0.11 11.9 0.1 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2093) Coatomer_E PF04733.14 EEA23965.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Coatomer epsilon subunit Fusion_gly PF00523.18 EEA23965.1 - 0.34 9.1 0.6 0.55 8.4 0.6 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 Metallophos PF00149.28 EEA23966.1 - 3.5e-12 47.3 0.0 5.3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA23966.1 - 2.7e-05 24.4 0.0 4.4e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EEA23966.1 - 0.023 14.0 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Tugs PF17840.1 EEA23966.1 - 0.046 13.9 0.0 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain LCCL PF03815.19 EEA23967.1 - 5.4e-22 77.7 0.1 9.1e-22 77.0 0.1 1.3 1 0 0 1 1 1 1 LCCL domain DUF4191 PF13829.6 EEA23967.1 - 0.088 12.1 2.6 0.21 10.9 2.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF1772 PF08592.11 EEA23968.1 - 8.1e-05 23.0 0.3 0.00024 21.4 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF1772) MARVEL PF01284.23 EEA23969.1 - 2.4e-18 66.6 9.6 2.9e-18 66.3 9.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain Papilloma_E5A PF05776.12 EEA23969.1 - 0.089 13.2 0.4 0.089 13.2 0.4 1.7 2 0 0 2 2 2 0 Papillomavirus E5A protein DUF4336 PF14234.6 EEA23970.1 - 6e-20 71.7 0.1 1.6e-13 50.5 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4336) Sld3_N PF18523.1 EEA23970.1 - 0.0098 16.0 0.1 5 7.3 0.1 2.3 1 1 1 2 2 2 2 Sld3 N-terminal domain Nse4_C PF08743.10 EEA23971.1 - 4.8e-30 103.7 0.0 1.7e-29 101.9 0.0 2.0 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EEA23971.1 - 2.5e-14 53.1 1.3 7.3e-14 51.6 1.3 1.8 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE PI3Ka PF00613.20 EEA23972.1 - 6.9e-58 195.1 0.1 1.2e-57 194.3 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EEA23972.1 - 4.9e-45 154.3 0.0 5e-31 108.4 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EEA23972.1 - 2.8e-32 111.5 0.0 4.7e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 FAA_hydrolase PF01557.18 EEA23972.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Fumarylacetoacetate (FAA) hydrolase family HCO3_cotransp PF00955.21 EEA23973.1 - 5.1e-70 236.7 13.3 4.8e-38 131.3 0.6 2.1 1 1 1 2 2 2 2 HCO3- transporter family MMR_HSR1 PF01926.23 EEA23974.1 - 3.5e-13 49.6 0.0 8e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA23974.1 - 3.4e-06 27.1 0.8 9.9e-06 25.6 0.8 1.7 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EEA23974.1 - 4.3e-06 26.3 0.0 7.2e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 EEA23974.1 - 0.00069 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Septin PF00735.18 EEA23974.1 - 0.0012 18.2 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 Septin Roc PF08477.13 EEA23974.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Isy1 PF06246.12 EEA23975.1 - 1.7e-89 299.8 3.7 1.9e-89 299.6 3.7 1.0 1 0 0 1 1 1 1 Isy1-like splicing family RlmM_FDX PF18125.1 EEA23975.1 - 0.026 15.0 0.4 0.056 13.9 0.4 1.5 1 0 0 1 1 1 0 RlmM ferredoxin-like domain YolD PF08863.10 EEA23975.1 - 0.061 13.4 0.1 0.15 12.1 0.1 1.6 1 0 0 1 1 1 0 YolD-like protein Myosin_head PF00063.21 EEA23976.1 - 1.5e-267 889.3 0.0 4e-267 887.9 0.0 1.8 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EEA23976.1 - 1.2e-15 56.5 274.5 8.7e-08 30.5 38.0 8.0 2 2 5 7 7 7 6 Myosin tail Myosin_N PF02736.19 EEA23976.1 - 9.3e-11 41.4 0.0 2.6e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Rootletin PF15035.6 EEA23976.1 - 0.0025 17.9 24.1 0.0025 17.9 24.1 10.2 2 2 6 9 9 9 1 Ciliary rootlet component, centrosome cohesion BPL_C PF02237.17 EEA23976.1 - 0.054 13.4 0.1 3.3 7.7 0.0 2.5 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain AAA_22 PF13401.6 EEA23976.1 - 0.07 13.4 0.0 0.07 13.4 0.0 5.4 6 0 0 6 6 6 0 AAA domain Erf4 PF10256.9 EEA23976.1 - 0.18 11.9 0.8 12 6.0 0.0 3.2 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Tnp_22_trimer PF17489.2 EEA23976.1 - 4.1 7.4 11.7 1.9 8.5 2.1 4.7 2 1 1 3 3 3 0 L1 transposable element trimerization domain zf-C3H1 PF10650.9 EEA23977.1 - 9.6e-13 47.6 1.0 1.6e-12 46.9 1.0 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain Ntox1 PF15500.6 EEA23977.1 - 0.00028 21.2 3.5 0.76 10.2 0.3 3.6 3 0 0 3 3 3 2 Putative RNase-like toxin, toxin_1 HAP1_N PF04849.13 EEA23977.1 - 0.16 11.1 7.2 0.33 10.1 3.1 2.3 2 0 0 2 2 2 0 HAP1 N-terminal conserved region zf-C3H1 PF10650.9 EEA23978.1 - 9.1e-13 47.7 1.0 1.6e-12 46.9 1.0 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain Ntox1 PF15500.6 EEA23978.1 - 0.00026 21.3 3.5 0.74 10.2 0.3 3.6 3 0 0 3 3 3 2 Putative RNase-like toxin, toxin_1 HAP1_N PF04849.13 EEA23978.1 - 0.15 11.2 7.2 0.32 10.2 3.1 2.3 2 0 0 2 2 2 0 HAP1 N-terminal conserved region THOC7 PF05615.13 EEA23978.1 - 2.6 8.3 12.7 5.1 7.4 1.4 3.2 3 0 0 3 3 3 0 Tho complex subunit 7 ApbA PF02558.16 EEA23979.1 - 5.4e-29 100.8 0.0 6.6e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EEA23979.1 - 3e-15 56.5 0.0 4.7e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal PglD_N PF17836.1 EEA23979.1 - 0.16 12.7 0.0 0.46 11.2 0.0 1.8 2 0 0 2 2 2 0 PglD N-terminal domain ABC_membrane PF00664.23 EEA23981.1 - 8.6e-39 133.8 11.8 1.1e-38 133.5 11.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EEA23981.1 - 3.9e-34 118.1 0.0 7.5e-34 117.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EEA23981.1 - 4.5e-06 26.3 0.0 0.0015 18.0 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA23981.1 - 0.00027 21.4 0.0 0.00068 20.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA23981.1 - 0.00051 20.3 0.0 0.0015 18.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EEA23981.1 - 0.0018 18.1 0.1 0.032 14.0 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_14 PF13173.6 EEA23981.1 - 0.026 14.5 0.0 0.53 10.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EEA23981.1 - 0.04 13.7 0.0 0.096 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EEA23981.1 - 0.049 14.0 0.0 0.32 11.4 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EEA23981.1 - 0.053 13.2 0.0 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 EEA23981.1 - 0.061 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 EEA23981.1 - 0.085 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EEA23981.1 - 0.12 12.6 0.0 0.42 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EEA23981.1 - 0.17 12.4 0.0 0.43 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AIM24 PF01987.17 EEA23982.1 - 2e-48 164.8 0.0 2.6e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 SprT-like PF10263.9 EEA23983.1 - 1.2e-34 118.5 0.3 2.4e-34 117.6 0.3 1.5 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 EEA23983.1 - 6.2e-08 32.4 3.0 1.2e-07 31.5 3.0 1.5 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EEA23983.1 - 0.045 13.9 0.3 0.11 12.6 0.3 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DUF4379 PF14311.6 EEA23983.1 - 0.1 13.0 1.1 0.4 11.1 1.1 2.1 1 0 0 1 1 1 0 Probable Zinc-ribbon domain Glucan_synthase PF02364.15 EEA23984.1 - 0 1385.9 0.0 0 1385.4 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EEA23984.1 - 3.2e-43 147.1 0.2 8.7e-43 145.7 0.2 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 BatA PF07584.11 EEA23984.1 - 2.1 8.8 6.0 9.6 6.7 0.1 3.3 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal Aminotran_1_2 PF00155.21 EEA23985.1 - 2.3e-38 132.3 0.0 2.7e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA23985.1 - 0.00059 18.5 0.0 0.0013 17.3 0.0 1.5 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Glyco_hydro_17 PF00332.18 EEA23986.1 - 5.7e-09 36.0 0.4 1.2e-08 35.0 0.2 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 DUF2013 PF09431.10 EEA23987.1 - 2.2e-51 173.7 0.6 2.2e-51 173.7 0.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Glyco_hydro_47 PF01532.20 EEA23988.1 - 3.9e-192 639.2 0.0 4.9e-192 638.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 APG9 PF04109.16 EEA23989.1 - 1.9e-211 703.2 15.1 2.3e-211 703.0 15.1 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 RasGAP PF00616.19 EEA23990.1 - 1.9e-30 106.1 0.0 2.2e-27 96.2 0.0 2.8 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EEA23990.1 - 2.8e-07 30.8 0.0 4.3e-06 27.0 0.0 2.4 2 0 0 2 2 2 1 C2 domain WD40 PF00400.32 EEA23991.1 - 5.1e-08 33.4 0.4 1.5 9.8 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat COQ9 PF08511.11 EEA23992.1 - 2.1e-27 94.7 0.1 4.4e-27 93.7 0.1 1.5 1 0 0 1 1 1 1 COQ9 RRM_1 PF00076.22 EEA23993.1 - 1.3e-47 159.5 0.0 3.3e-17 62.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA23993.1 - 4.2e-05 23.1 0.0 0.091 12.4 0.0 2.7 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EEA23993.1 - 0.00067 19.7 0.1 7.8 6.6 0.0 4.1 3 2 0 3 3 3 1 Limkain b1 RRM_3 PF08777.11 EEA23993.1 - 0.00091 19.2 0.0 3.7 7.7 0.0 3.4 3 0 0 3 3 3 2 RNA binding motif RRM_Rrp7 PF17799.1 EEA23993.1 - 0.04 13.7 0.0 1.2 8.9 0.0 2.7 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain PH PF00169.29 EEA23994.1 - 0.00017 22.1 0.1 0.00072 20.0 0.0 2.2 2 0 0 2 2 2 1 PH domain DUF3921 PF13060.6 EEA23994.1 - 0.054 13.5 0.2 0.17 12.0 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3921) DUF5344 PF17279.2 EEA23994.1 - 0.1 13.2 0.6 1.6 9.4 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Tim17 PF02466.19 EEA23995.1 - 2.1e-06 28.0 10.5 3.9e-06 27.2 10.5 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family RPT PF13446.6 EEA23996.1 - 2.5e-55 184.2 0.1 2.1e-20 72.4 0.0 4.6 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH PF00443.29 EEA23996.1 - 6.1e-41 140.6 0.0 2.5e-40 138.6 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WRKY PF03106.15 EEA23996.1 - 0.015 15.5 0.2 0.16 12.2 0.0 2.4 2 0 0 2 2 2 0 WRKY DNA -binding domain UCH_1 PF13423.6 EEA23996.1 - 0.018 14.6 6.1 0.22 11.1 6.1 2.5 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Vps39_2 PF10367.9 EEA23996.1 - 0.13 12.8 0.3 0.96 9.9 0.2 2.4 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 Pkinase PF00069.25 EEA23997.1 - 6.9e-68 228.9 0.0 9.1e-68 228.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA23997.1 - 1.8e-31 109.4 0.0 2.8e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA23997.1 - 0.0081 15.1 0.0 0.016 14.1 0.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA23997.1 - 0.038 13.3 0.1 0.082 12.2 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA23997.1 - 0.052 13.5 0.4 0.17 11.8 0.0 1.9 3 0 0 3 3 3 0 Phosphotransferase enzyme family DIT1_PvcA PF05141.12 EEA23999.1 - 9.8e-85 284.4 0.0 1.4e-84 283.8 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein TauD PF02668.16 EEA23999.1 - 3.8e-15 56.4 0.0 7.7e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DAHP_snth_FXD PF18152.1 EEA23999.1 - 0.16 11.8 0.0 0.45 10.4 0.0 1.7 1 0 0 1 1 1 0 DAHP synthase ferredoxin-like domain FAD_binding_3 PF01494.19 EEA24000.1 - 2.5e-57 194.7 0.0 3.4e-57 194.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EEA24000.1 - 4.6e-05 22.8 0.2 0.00042 19.7 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA24000.1 - 0.00021 21.8 0.0 0.0034 17.9 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA24000.1 - 0.00022 21.4 0.4 0.00086 19.5 0.1 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA24000.1 - 0.00039 20.1 0.7 0.0041 16.8 0.4 2.4 3 1 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA24000.1 - 0.00053 19.2 0.2 0.0017 17.5 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EEA24000.1 - 0.00054 18.8 0.4 0.0015 17.3 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EEA24000.1 - 0.00071 18.9 0.0 0.0029 16.9 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA24000.1 - 0.00098 18.6 0.4 0.0018 17.7 0.2 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EEA24000.1 - 0.0011 18.1 0.3 0.0048 16.0 0.1 2.0 3 0 0 3 3 3 1 Lycopene cyclase protein Thi4 PF01946.17 EEA24000.1 - 0.002 17.4 0.2 0.015 14.6 0.1 2.1 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 EEA24000.1 - 0.011 15.0 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 EEA24000.1 - 0.032 13.1 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 EEA24000.1 - 0.078 12.0 0.1 0.15 11.1 0.0 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A XdhC_C PF13478.6 EEA24000.1 - 0.12 12.8 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain SAT PF16073.5 EEA24001.1 - 1.2e-55 188.8 0.0 1.5e-55 188.6 0.0 1.1 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis adh_short_C2 PF13561.6 EEA24002.1 - 1.9e-32 112.7 0.0 3.9e-32 111.7 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA24002.1 - 6.3e-28 97.6 0.1 3.9e-27 95.0 0.0 2.1 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA24002.1 - 0.00096 19.1 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 KR domain YCII PF03795.14 EEA24003.1 - 6.3e-06 26.5 0.0 7.3e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain AAA_18 PF13238.6 EEA24003.1 - 0.048 14.2 0.0 0.052 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain Dabb PF07876.12 EEA24004.1 - 4.9e-11 43.1 0.0 5.6e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Whirly PF08536.11 EEA24004.1 - 0.041 13.7 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 Whirly transcription factor ADH_zinc_N PF00107.26 EEA24005.1 - 7.1e-28 97.2 0.1 1.4e-27 96.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA24005.1 - 5.6e-17 63.0 0.1 1.1e-16 62.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA24005.1 - 4.9e-07 29.6 0.1 1.6e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EEA24005.1 - 0.064 12.7 0.1 0.12 11.8 0.1 1.5 1 1 0 1 1 1 0 short chain dehydrogenase FAD_binding_3 PF01494.19 EEA24006.1 - 1.3e-68 231.8 0.0 1.6e-68 231.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EEA24006.1 - 5.4e-06 26.5 0.0 1.4e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.24 EEA24006.1 - 0.00032 20.4 0.0 0.0069 16.0 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA24006.1 - 0.0029 16.9 0.0 0.0043 16.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA24006.1 - 0.0074 15.7 0.2 0.011 15.1 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA24006.1 - 0.042 12.9 0.1 0.074 12.1 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain SE PF08491.10 EEA24006.1 - 0.11 11.5 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase Pyr_redox PF00070.27 EEA24006.1 - 0.16 12.6 0.1 4.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EEA24007.1 - 3.8e-16 59.0 53.8 1.5e-13 50.4 33.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF389 PF04087.14 EEA24007.1 - 0.0014 18.7 2.5 0.0014 18.7 2.5 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF389) Aminotran_4 PF01063.19 EEA24008.1 - 1.7e-21 77.1 0.0 2e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV CoA_transf_3 PF02515.17 EEA24009.1 - 6.1e-36 124.3 0.0 1.7e-35 122.9 0.0 1.6 2 0 0 2 2 2 1 CoA-transferase family III DUF2370 PF10176.9 EEA24010.1 - 6.7e-93 310.5 0.0 1.1e-92 309.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) DUF2370 PF10176.9 EEA24011.1 - 4.7e-93 311.0 0.0 6.5e-93 310.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) CoA_trans PF01144.23 EEA24013.1 - 2.4e-105 350.7 1.3 3.4e-65 219.5 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase WSC PF01822.19 EEA24014.1 - 4.7e-12 45.9 11.2 9.8e-12 44.9 11.2 1.5 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 EEA24014.1 - 2.6e-08 33.1 3.0 6.5e-08 31.9 3.0 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Amnionless PF14828.6 EEA24014.1 - 0.018 13.9 0.1 0.018 13.9 0.1 1.4 2 0 0 2 2 2 0 Amnionless DUF5305 PF17231.2 EEA24014.1 - 0.022 14.1 0.2 0.032 13.6 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) EphA2_TM PF14575.6 EEA24014.1 - 0.031 15.1 0.0 0.075 13.9 0.0 1.7 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain MGC-24 PF05283.11 EEA24014.1 - 0.034 14.6 5.9 0.054 13.9 5.6 1.5 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TrbL PF04610.14 EEA24014.1 - 0.039 13.7 3.3 0.057 13.2 3.3 1.2 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein Nitrate_red_gam PF02665.14 EEA24014.1 - 0.039 13.5 0.2 0.073 12.6 0.2 1.4 1 0 0 1 1 1 0 Nitrate reductase gamma subunit DUF3042 PF11240.8 EEA24014.1 - 0.096 12.7 0.2 0.21 11.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Insulin_TMD PF17870.1 EEA24014.1 - 0.16 12.1 0.1 0.31 11.1 0.1 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Trp_oprn_chp PF09534.10 EEA24014.1 - 0.73 9.6 9.0 0.02 14.7 2.7 1.6 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Gram_pos_anchor PF00746.21 EEA24014.1 - 5 7.2 11.1 0.12 12.3 2.5 2.7 2 1 0 2 2 2 0 LPXTG cell wall anchor motif Herpes_capsid PF06112.11 EEA24014.1 - 9.3 6.3 11.5 21 5.1 11.5 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CDP-OH_P_transf PF01066.21 EEA24015.1 - 4e-13 49.9 0.4 1.4e-12 48.2 0.0 2.1 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Gar1 PF04410.14 EEA24016.1 - 6.8e-39 133.1 0.0 8.8e-39 132.7 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region tRNA-synt_2b PF00587.25 EEA24017.1 - 2.1e-31 109.3 0.0 6.1e-28 98.0 0.0 2.5 1 1 1 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EEA24017.1 - 5e-16 58.6 0.1 1.3e-15 57.3 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EEA24017.1 - 2.5e-13 49.9 0.0 4.6e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EEA24017.1 - 0.0065 16.5 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain Fungal_trans PF04082.18 EEA24018.1 - 3.7e-21 75.4 0.9 6.4e-21 74.6 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 EEA24018.1 - 0.0022 18.7 9.0 0.025 15.4 1.0 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA24018.1 - 0.0035 17.7 2.0 0.0035 17.7 2.0 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 EEA24018.1 - 0.26 11.9 4.4 9.3 7.0 0.3 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain Form_Nir_trans PF01226.17 EEA24019.1 - 6.1e-72 241.8 20.6 7.2e-72 241.5 20.6 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter DUF2107 PF09880.9 EEA24019.1 - 0.012 15.7 0.2 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2107) UPF0016 PF01169.19 EEA24019.1 - 0.07 13.5 0.3 0.07 13.5 0.3 3.5 2 1 1 3 3 3 0 Uncharacterized protein family UPF0016 Fungal_trans PF04082.18 EEA24021.1 - 2.5e-09 36.6 0.3 4.8e-09 35.6 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24021.1 - 5.9e-09 35.9 10.0 1.3e-08 34.8 10.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Atg14 PF10186.9 EEA24021.1 - 0.63 9.1 4.4 1 8.4 4.4 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 G_glu_transpept PF01019.21 EEA24022.1 - 7.4e-140 467.1 0.0 8.5e-140 466.9 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase MFS_1 PF07690.16 EEA24024.1 - 1.7e-50 171.9 51.8 1.5e-46 158.9 35.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TPMT PF05724.11 EEA24025.1 - 3.2e-24 85.8 0.0 5.4e-24 85.1 0.0 1.3 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 EEA24025.1 - 3.8e-08 33.9 0.0 7.8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA24025.1 - 2.9e-07 30.5 0.0 4.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA24025.1 - 9.9e-07 29.4 0.0 2.7e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA24025.1 - 1.1e-06 28.5 0.0 1.9e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA24025.1 - 0.01 16.5 0.0 0.026 15.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 EEA24025.1 - 0.085 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB OTU PF02338.19 EEA24026.1 - 4e-22 79.1 0.0 2.4e-17 63.6 0.0 2.4 2 0 0 2 2 2 2 OTU-like cysteine protease Peptidase_C65 PF10275.9 EEA24026.1 - 1.2e-05 24.9 0.1 0.0025 17.3 0.0 2.7 3 0 0 3 3 3 2 Peptidase C65 Otubain NIL PF09383.10 EEA24026.1 - 0.038 13.8 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 NIL domain ApbA_C PF08546.11 EEA24026.1 - 0.047 13.9 2.8 0.57 10.4 0.1 2.6 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA C terminal ThiD2 PF17792.1 EEA24026.1 - 0.6 10.6 7.4 3.8 8.0 1.1 2.4 2 0 0 2 2 2 0 ThiD2 family DUF4678 PF15727.5 EEA24026.1 - 1.6 7.9 6.8 2 7.6 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) DUF4551 PF15087.6 EEA24026.1 - 2.9 6.6 7.1 3.6 6.3 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) adh_short_C2 PF13561.6 EEA24027.1 - 2.6e-48 164.6 0.0 3e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA24027.1 - 4.2e-45 153.6 0.0 5.8e-45 153.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA24027.1 - 3.8e-08 33.4 0.0 6.3e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Trehalase PF01204.18 EEA24028.1 - 5.7e-185 616.0 0.0 6.7e-185 615.8 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EEA24028.1 - 9e-15 54.1 0.1 1.4e-14 53.5 0.1 1.3 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain ICL PF00463.21 EEA24029.1 - 2.7e-294 976.5 3.0 3.1e-294 976.4 3.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EEA24029.1 - 6.6e-12 45.4 0.1 1.9e-11 43.9 0.0 1.7 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Fungal_trans PF04082.18 EEA24030.1 - 4.3e-13 48.9 0.1 8.2e-13 48.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dabb PF07876.12 EEA24031.1 - 4.8e-14 52.8 0.1 5.7e-14 52.5 0.1 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain FAA_hydrolase PF01557.18 EEA24032.1 - 5.4e-52 176.6 0.0 7.5e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EEA24032.1 - 3.8e-11 43.1 0.0 9.8e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal HgmA PF04209.13 EEA24033.1 - 1.8e-35 122.5 0.0 2.3e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase p450 PF00067.22 EEA24033.1 - 1.2e-23 83.6 0.0 4.6e-13 48.7 0.1 2.1 2 0 0 2 2 2 2 Cytochrome P450 Aldedh PF00171.22 EEA24034.1 - 5.2e-75 252.7 0.0 6.9e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PIG-H PF10181.9 EEA24034.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component Asparaginase_2 PF01112.18 EEA24034.1 - 0.094 11.7 0.2 0.15 11.0 0.2 1.2 1 0 0 1 1 1 0 Asparaginase Adap_comp_sub PF00928.21 EEA24035.1 - 2.8e-59 200.7 0.0 5.8e-59 199.6 0.0 1.5 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EEA24035.1 - 0.00015 21.7 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Rrn6 PF10214.9 EEA24035.1 - 1.2 7.5 9.4 1.7 7.0 9.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF4536 PF15055.6 EEA24036.1 - 2.5e-08 34.0 3.3 7.1e-08 32.6 0.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) DUF4588 PF15251.6 EEA24037.1 - 2.2e-07 30.9 0.2 2.9e-07 30.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) Inhibitor_I53 PF11714.8 EEA24037.1 - 0.1 12.8 2.4 0.2 11.9 2.4 1.5 1 0 0 1 1 1 0 Thrombin inhibitor Madanin SNF2_N PF00176.23 EEA24038.1 - 1.8e-75 253.8 0.1 3.1e-75 253.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EEA24038.1 - 2e-40 137.4 2.5 8.1e-40 135.4 2.5 2.2 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 EEA24038.1 - 3.9e-38 130.6 0.5 3.9e-38 130.6 0.5 3.9 4 0 0 4 4 3 1 HAND Helicase_C PF00271.31 EEA24038.1 - 2.6e-18 66.4 0.5 3.2e-17 62.9 0.0 2.8 3 0 0 3 3 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA24038.1 - 1.3e-10 41.5 1.7 3.5e-10 40.2 0.0 2.7 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EEA24038.1 - 5.5e-07 29.1 0.0 1.8e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EEA24038.1 - 0.0002 21.2 0.0 0.00062 19.6 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EEA24038.1 - 0.00036 20.3 0.0 0.0012 18.5 0.0 1.9 1 0 0 1 1 1 1 SWI2/SNF2 ATPase Sporozoite_P67 PF05642.11 EEA24038.1 - 0.012 13.8 6.9 0.02 13.0 6.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ERCC3_RAD25_C PF16203.5 EEA24038.1 - 0.013 14.7 0.2 0.032 13.4 0.2 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 EEA24038.1 - 0.021 14.9 0.0 0.1 12.6 0.0 2.2 1 0 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.31 EEA24038.1 - 0.026 14.7 0.2 3 8.1 0.0 2.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain DEAD_2 PF06733.15 EEA24038.1 - 0.034 13.8 0.1 0.081 12.5 0.1 1.6 1 0 0 1 1 1 0 DEAD_2 Ku_C PF03730.14 EEA24038.1 - 0.61 10.8 5.6 0.23 12.2 1.3 2.7 2 0 0 2 2 1 0 Ku70/Ku80 C-terminal arm Ank_2 PF12796.7 EEA24039.1 - 1.3e-58 195.6 14.2 5.8e-12 46.0 0.1 8.6 3 2 5 9 9 9 8 Ankyrin repeats (3 copies) Ank PF00023.30 EEA24039.1 - 2.6e-50 166.8 1.9 3.1e-05 24.2 0.2 14.7 15 1 0 15 15 15 9 Ankyrin repeat Ank_5 PF13857.6 EEA24039.1 - 7.9e-50 166.3 21.7 3.9e-11 43.0 0.0 12.0 9 3 3 12 12 12 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA24039.1 - 2.3e-49 165.2 22.7 6.4e-08 33.0 0.0 12.9 8 4 4 13 13 13 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA24039.1 - 2.6e-44 144.1 16.2 6.4e-06 26.1 0.0 15.9 17 0 0 17 17 16 6 Ankyrin repeat NACHT PF05729.12 EEA24039.1 - 8.8e-09 35.5 0.3 9e-08 32.2 0.1 2.7 3 0 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 EEA24039.1 - 3.1e-07 30.7 0.0 1.4e-06 28.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA24039.1 - 9.4e-05 22.9 0.0 0.00037 20.9 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain Helo_like_N PF17111.5 EEA24039.1 - 0.00036 20.0 0.0 0.00085 18.8 0.0 1.6 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EEA24039.1 - 0.0012 19.1 0.1 0.0045 17.2 0.1 2.0 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NB-ARC PF00931.22 EEA24039.1 - 0.0073 15.5 0.0 0.018 14.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 EEA24039.1 - 0.012 16.1 0.0 0.057 13.9 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EEA24039.1 - 0.8 9.4 3.8 12 5.5 0.1 2.7 1 1 1 2 2 2 0 AAA domain Asp PF00026.23 EEA24041.1 - 2.6e-66 224.2 7.6 3.2e-66 223.9 7.6 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA24041.1 - 8.4e-14 52.2 1.0 2.8e-12 47.2 1.0 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA24041.1 - 3.1e-05 24.5 6.1 0.12 13.1 0.0 3.7 3 1 1 4 4 4 2 Aspartyl protease SpoU_methylase PF00588.19 EEA24042.1 - 1.9e-24 86.4 0.2 1.7e-23 83.4 0.2 2.3 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EEA24042.1 - 4.6e-07 30.0 0.0 9.7e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding zf-PHD-like PF15446.6 EEA24043.1 - 2.2e-68 229.2 12.8 2.2e-68 229.2 12.8 2.0 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 EEA24043.1 - 9.4e-53 179.1 0.1 1.5e-52 178.5 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CCCH_6 PF18585.1 EEA24043.1 - 4.4e-25 87.3 0.4 1.4e-24 85.7 0.4 2.0 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 EEA24043.1 - 1.5e-18 67.1 0.0 3.8e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EEA24043.1 - 1.6e-10 40.6 2.7 3.4e-10 39.6 2.7 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD PF00628.29 EEA24043.1 - 3.8e-06 26.7 19.1 1.1e-05 25.3 5.5 3.3 3 1 0 3 3 2 2 PHD-finger Chromo PF00385.24 EEA24043.1 - 1.3e-05 25.0 5.3 0.043 13.7 3.3 3.2 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DUF1087 PF06465.13 EEA24043.1 - 0.00021 21.3 0.0 0.0011 18.9 0.0 2.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) ResIII PF04851.15 EEA24043.1 - 0.0079 16.2 0.0 0.028 14.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Myc_N PF01056.18 EEA24043.1 - 0.015 15.2 0.4 0.015 15.2 0.4 2.3 3 0 0 3 3 2 0 Myc amino-terminal region VapB_antitoxin PF09957.9 EEA24043.1 - 0.032 14.1 0.1 0.09 12.7 0.1 1.8 1 0 0 1 1 1 0 Bacterial antitoxin of type II TA system, VapB C1_1 PF00130.22 EEA24043.1 - 7.7 6.5 17.5 0.59 10.1 2.3 3.6 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Torus PF16131.5 EEA24044.1 - 0.013 16.2 0.1 0.022 15.4 0.1 1.3 1 0 0 1 1 1 0 Torus domain MRP-S28 PF10213.9 EEA24045.1 - 4.5e-45 153.1 0.3 1.2e-44 151.8 0.3 1.7 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Glyco_tran_28_C PF04101.16 EEA24046.1 - 5e-18 65.6 0.0 3.3e-17 63.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 EEA24046.1 - 0.005 15.7 0.0 0.0067 15.3 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ECH_1 PF00378.20 EEA24046.1 - 0.049 13.0 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Glycos_transf_1 PF00534.20 EEA24046.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 Actin PF00022.19 EEA24047.1 - 7.5e-129 429.9 0.0 3.7e-128 427.6 0.0 1.8 1 1 0 1 1 1 1 Actin Peptidase_M24_C PF16188.5 EEA24047.1 - 0.12 12.4 0.1 0.26 11.4 0.1 1.4 1 0 0 1 1 1 0 C-terminal region of peptidase_M24 Acetyltransf_10 PF13673.7 EEA24048.1 - 3.3e-09 36.7 0.0 4.4e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA24048.1 - 1e-08 35.4 0.0 1.3e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA24048.1 - 6.1e-06 26.6 0.0 9.2e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA24048.1 - 8.2e-05 22.8 0.0 0.00011 22.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA24048.1 - 0.021 14.9 0.6 0.19 11.8 0.6 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain 3HCDH_N PF02737.18 EEA24049.1 - 2e-27 96.2 0.0 4.4e-27 95.1 0.0 1.6 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EEA24049.1 - 1.6e-10 41.5 0.0 3.7e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Pyr_redox PF00070.27 EEA24049.1 - 0.084 13.4 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA24049.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain zf-CCHC PF00098.23 EEA24050.1 - 3e-53 175.6 96.9 6.6e-07 29.1 2.2 11.3 11 0 0 11 11 11 11 Zinc knuckle zf-CCHC_4 PF14392.6 EEA24050.1 - 4.4e-10 39.1 64.8 0.00017 21.2 0.1 10.9 11 0 0 11 11 11 7 Zinc knuckle zf-CCHC_3 PF13917.6 EEA24050.1 - 2.7e-09 36.8 68.9 0.17 11.8 0.6 11.1 2 2 9 11 11 11 9 Zinc knuckle zf-CCHC_2 PF13696.6 EEA24050.1 - 1.4e-07 31.2 18.2 5.7e-05 22.8 2.0 10.7 11 0 0 11 11 11 6 Zinc knuckle zf-CCHC_6 PF15288.6 EEA24050.1 - 0.0092 15.8 0.5 0.0092 15.8 0.5 11.0 10 1 1 11 11 11 5 Zinc knuckle zf-C2H2_10 PF16588.5 EEA24050.1 - 0.049 13.4 0.7 0.049 13.4 0.7 8.8 9 0 0 9 9 9 0 C2H2 zinc-finger SCVP PF17619.2 EEA24050.1 - 6.1 7.8 10.3 0.36 11.7 1.0 3.1 3 1 0 3 3 3 0 Secreted clade V proteins Sugar_tr PF00083.24 EEA24051.1 - 1.9e-111 373.2 24.4 2.3e-111 372.9 24.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24051.1 - 6.1e-15 55.0 39.0 2.6e-13 49.6 9.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EEA24051.1 - 2.9e-05 22.6 2.6 2.9e-05 22.6 2.6 1.8 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Gln-synt_C PF00120.24 EEA24052.1 - 8.9e-17 61.1 0.0 5.2e-14 52.0 0.0 2.2 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EEA24052.1 - 9e-14 51.0 0.0 1.6e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Med1 PF10744.9 EEA24053.1 - 7e-124 414.0 0.0 1e-123 413.5 0.0 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Methyltransf_32 PF13679.6 EEA24058.1 - 1.1e-21 77.4 0.1 3.1e-21 76.0 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.11 EEA24060.1 - 2.8e-26 91.9 0.6 1.1e-25 90.1 0.1 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 EEA24060.1 - 0.00027 20.9 0.2 0.00055 19.9 0.2 1.6 1 0 0 1 1 1 1 SNARE domain Cnn_1N PF07989.11 EEA24060.1 - 0.0063 16.6 1.9 0.14 12.3 0.0 2.5 3 0 0 3 3 3 1 Centrosomin N-terminal motif 1 Phage_int_SAM_2 PF12834.7 EEA24060.1 - 0.065 13.9 0.2 2 9.2 0.0 2.5 2 0 0 2 2 2 0 Phage integrase, N-terminal APG6_N PF17675.1 EEA24060.1 - 0.12 12.9 1.6 3.4 8.2 0.2 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF5132 PF17195.4 EEA24060.1 - 0.27 11.3 1.7 7.9 6.7 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) DUF4164 PF13747.6 EEA24060.1 - 0.47 10.8 7.7 9.7 6.6 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Ribosomal_L29 PF00831.23 EEA24060.1 - 0.56 10.2 2.3 0.89 9.6 0.0 2.6 4 0 0 4 4 4 0 Ribosomal L29 protein NPV_P10 PF05531.12 EEA24060.1 - 2.6 8.6 5.8 40 4.8 0.1 3.6 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein NAP PF00956.18 EEA24061.1 - 9e-24 84.1 8.9 9e-24 84.1 8.9 2.9 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) AIM3 PF17096.5 EEA24061.1 - 0.035 15.1 2.6 0.11 13.4 0.1 2.3 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 BT1 PF03092.16 EEA24061.1 - 0.092 11.0 1.1 0.13 10.5 1.1 1.1 1 0 0 1 1 1 0 BT1 family DUF4611 PF15387.6 EEA24061.1 - 3.2 8.0 34.4 0.32 11.2 5.4 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) RPN2_C PF18004.1 EEA24061.1 - 3.8 7.4 16.4 0.56 10.1 5.1 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Asparaginase PF00710.20 EEA24062.1 - 1.2e-58 197.9 0.0 1.6e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EEA24062.1 - 1.3e-26 93.1 0.1 3e-26 91.9 0.1 1.7 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 EEA24062.1 - 2.7e-16 59.9 0.5 9.1e-10 39.0 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA24062.1 - 7.7e-10 39.1 0.1 4.8e-05 23.8 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA24062.1 - 1.5e-08 34.2 0.3 0.022 15.2 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EEA24062.1 - 7.7e-08 32.5 0.0 1.3e-06 28.6 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EEA24062.1 - 1.1e-07 31.9 2.3 0.0046 17.4 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat NmrA PF05368.13 EEA24063.1 - 1.2e-71 241.0 0.0 1.5e-71 240.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family DUF1996 PF09362.10 EEA24064.1 - 3e-77 259.8 0.4 4e-77 259.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) TALPID3 PF15324.6 EEA24064.1 - 2.7 5.5 6.5 3.6 5.1 6.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Aldo_ket_red PF00248.21 EEA24065.1 - 3.3e-71 239.9 0.0 3.7e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Phage_ABA_S PF18066.1 EEA24065.1 - 0.048 14.3 0.1 0.36 11.6 0.0 2.3 2 0 0 2 2 2 0 Phage ABA sandwich domain Pyr_redox_2 PF07992.14 EEA24066.1 - 6.2e-41 140.5 1.1 8e-41 140.2 1.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA24066.1 - 5.8e-13 49.2 0.6 4.3e-10 40.0 0.3 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA24066.1 - 1.2e-08 34.6 2.1 7.6e-07 28.7 0.8 2.1 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA24066.1 - 9.4e-08 31.5 2.8 0.025 13.6 0.0 3.2 2 1 1 3 3 3 3 Lycopene cyclase protein K_oxygenase PF13434.6 EEA24066.1 - 0.00047 19.4 1.8 0.5 9.4 0.1 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EEA24066.1 - 0.00056 19.9 0.2 0.77 9.7 0.1 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EEA24066.1 - 0.0059 15.9 4.7 0.11 11.7 0.2 2.6 3 0 0 3 3 3 2 Thi4 family DUF5130 PF17174.4 EEA24066.1 - 0.032 14.5 0.6 0.63 10.2 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5130) Mqo PF06039.15 EEA24066.1 - 0.067 11.7 0.4 0.65 8.5 0.1 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) DAO PF01266.24 EEA24066.1 - 0.091 12.3 7.9 1.3 8.5 2.7 3.5 2 1 1 3 3 3 0 FAD dependent oxidoreductase SH3_10 PF17902.1 EEA24066.1 - 0.1 12.7 0.1 0.57 10.3 0.1 2.2 2 0 0 2 2 2 0 SH3 domain NAD_binding_8 PF13450.6 EEA24066.1 - 0.13 12.5 0.1 23 5.3 0.0 3.1 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA24066.1 - 0.13 10.9 10.3 1.1 7.8 0.5 3.4 3 1 1 4 4 4 0 HI0933-like protein Amino_oxidase PF01593.24 EEA24066.1 - 0.19 11.0 1.1 0.35 10.1 0.2 1.7 1 1 1 2 2 2 0 Flavin containing amine oxidoreductase AA_permease_2 PF13520.6 EEA24067.1 - 2.7e-43 148.4 51.9 3.5e-43 148.0 51.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA24067.1 - 1.9e-17 63.1 38.3 2.6e-17 62.6 38.3 1.1 1 0 0 1 1 1 1 Amino acid permease adh_short PF00106.25 EEA24068.1 - 2.2e-22 79.5 0.0 8.5e-20 71.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24068.1 - 3.1e-17 62.9 0.0 7e-16 58.5 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24068.1 - 1.1e-09 38.5 0.2 2e-09 37.6 0.2 1.3 1 0 0 1 1 1 1 KR domain Pyr_redox_2 PF07992.14 EEA24068.1 - 0.0021 17.3 0.2 0.0034 16.7 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UPF0051 PF01458.17 EEA24068.1 - 0.084 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein family (UPF0051) 3HCDH_N PF02737.18 EEA24068.1 - 0.1 12.5 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_hydro_127 PF07944.12 EEA24069.1 - 1.5e-24 86.4 0.0 2.2e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 RVT_2 PF07727.14 EEA24070.1 - 9.1e-11 41.9 0.0 1.6e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA24070.1 - 1.9e-07 31.3 1.9 5.5e-06 26.6 0.0 3.3 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 EEA24070.1 - 0.00023 21.0 0.2 0.00072 19.4 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Cu_amine_oxid PF01179.20 EEA24070.1 - 0.025 13.5 1.5 0.046 12.6 1.5 1.3 1 0 0 1 1 1 0 Copper amine oxidase, enzyme domain Integrase_H2C2 PF17921.1 EEA24070.1 - 2 8.6 13.0 0.45 10.7 0.1 4.3 4 0 0 4 4 4 0 Integrase zinc binding domain PNTB PF02233.16 EEA24072.1 - 5.6e-175 582.7 25.4 5.6e-175 582.7 25.4 1.9 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EEA24072.1 - 2.5e-69 232.9 0.1 2.5e-69 232.9 0.1 2.6 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EEA24072.1 - 4.7e-46 156.5 0.0 9.5e-46 155.5 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EEA24072.1 - 6.8e-30 103.4 3.5 6.8e-30 103.4 3.5 5.0 4 1 1 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EEA24072.1 - 0.0074 15.7 0.1 1.2 8.5 0.1 2.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EEA24072.1 - 0.011 15.0 0.2 0.028 13.7 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.22 EEA24072.1 - 0.023 14.4 0.2 0.091 12.5 0.2 2.0 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain CoA_binding PF02629.19 EEA24072.1 - 0.044 14.5 4.4 0.69 10.6 0.9 2.9 2 1 0 2 2 2 0 CoA binding domain PRIMA1 PF16101.5 EEA24072.1 - 0.2 11.7 5.9 0.13 12.3 3.2 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 NAD_binding_8 PF13450.6 EEA24072.1 - 0.31 11.3 3.9 0.15 12.3 0.4 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain CAP_N PF01213.19 EEA24072.1 - 1.3 8.5 2.6 2.4 7.5 2.6 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal ELO PF01151.18 EEA24074.1 - 4.5e-62 209.8 26.2 5.3e-62 209.6 26.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family COX5A PF02284.16 EEA24075.1 - 4.1e-38 129.5 0.4 5.7e-38 129.1 0.4 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Glyco_transf_15 PF01793.16 EEA24076.1 - 7.7e-115 383.6 10.4 9.7e-115 383.3 10.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase GCP_N_terminal PF17681.1 EEA24077.1 - 1.5e-33 116.7 1.1 1.5e-33 116.7 1.1 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EEA24077.1 - 1.4e-27 97.0 1.0 2.5e-27 96.2 1.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 EEA24077.1 - 1.1e-06 27.4 0.1 4e-06 25.5 0.1 2.0 1 1 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 MBA1 PF07961.11 EEA24077.1 - 0.049 12.7 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 MBA1-like protein FAM176 PF14851.6 EEA24077.1 - 0.92 9.2 5.7 14 5.3 5.4 2.3 2 0 0 2 2 2 0 FAM176 family FYDLN_acid PF09538.10 EEA24077.1 - 6.7 7.4 10.1 11 6.7 5.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) GATase_5 PF13507.6 EEA24078.1 - 7e-103 343.2 0.0 1e-102 342.7 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EEA24078.1 - 8.7e-40 136.4 0.7 2.9e-24 86.0 0.5 2.4 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EEA24078.1 - 3.9e-34 117.1 0.0 1.7e-33 115.0 0.0 2.1 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EEA24078.1 - 2e-21 76.2 0.0 4.4e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain MFS_1 PF07690.16 EEA24079.1 - 2.2e-43 148.6 29.0 2.2e-43 148.6 29.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA24079.1 - 1.4e-09 37.0 1.9 2.2e-09 36.3 1.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA24079.1 - 2.8e-08 33.0 22.0 9.6e-08 31.3 22.0 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2178 PF09946.9 EEA24079.1 - 0.35 11.0 8.0 0.32 11.2 0.5 3.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2178) DUF996 PF06195.13 EEA24079.1 - 0.42 10.9 10.7 0.099 12.9 1.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF996) Fungal_trans PF04082.18 EEA24080.1 - 2e-09 36.9 0.0 3.3e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24080.1 - 2.3e-06 27.6 12.2 4.2e-06 26.8 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA24081.1 - 1.8e-09 37.0 0.0 3.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24081.1 - 2.2e-06 27.7 12.2 4.1e-06 26.8 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_2 PF07719.17 EEA24082.1 - 4.8e-27 91.8 16.4 0.00048 20.0 0.5 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.28 EEA24082.1 - 3.5e-26 89.9 8.8 9.4e-05 22.1 1.1 9.5 9 0 0 9 9 9 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA24082.1 - 3.3e-25 88.1 16.3 2.1e-19 69.5 0.9 5.8 5 1 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EEA24082.1 - 3.8e-17 61.0 6.9 0.033 14.4 0.2 8.8 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 EEA24082.1 - 7.5e-16 58.4 15.8 0.00047 20.6 0.1 7.0 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24082.1 - 2.8e-14 53.1 25.9 0.019 15.3 0.1 9.5 7 4 1 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24082.1 - 1.4e-11 44.2 19.9 0.26 12.2 0.1 9.2 8 3 2 10 10 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24082.1 - 3.9e-11 43.4 24.3 0.083 13.6 0.1 8.8 8 1 2 10 10 10 4 Tetratricopeptide repeat TPR_10 PF13374.6 EEA24082.1 - 1e-10 41.1 14.0 0.00026 20.8 0.0 7.5 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA24082.1 - 4.5e-09 35.9 10.5 0.37 10.5 0.1 8.2 9 0 0 9 9 9 3 TPR repeat TPR_7 PF13176.6 EEA24082.1 - 4.9e-08 32.4 16.1 0.8 9.9 0.1 9.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA24082.1 - 1.9e-07 31.3 12.9 0.31 11.8 0.3 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA24082.1 - 0.00018 21.6 9.5 1.2 9.6 0.1 7.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_4 PF07721.14 EEA24082.1 - 0.0016 18.9 10.2 0.085 13.5 0.6 6.4 7 0 0 7 7 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 EEA24082.1 - 0.022 14.5 3.5 3 7.5 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.5 EEA24082.1 - 0.074 13.1 0.0 0.46 10.5 0.0 2.4 2 0 0 2 2 2 0 Putative TPR-like repeat Calsequestrin PF01216.17 EEA24082.1 - 0.1 11.6 0.1 0.15 11.0 0.1 1.1 1 0 0 1 1 1 0 Calsequestrin TPR_MalT PF17874.1 EEA24082.1 - 0.12 11.8 9.4 0.71 9.2 0.2 3.8 3 1 0 4 4 4 0 MalT-like TPR region DUF572 PF04502.13 EEA24083.1 - 6.1e-71 239.7 13.0 7.3e-71 239.5 13.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Zn_ribbon_SprT PF17283.2 EEA24083.1 - 0.72 9.8 3.8 0.71 9.8 2.2 1.8 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zf-ACC PF17848.1 EEA24083.1 - 1.2 9.3 4.9 2.5 8.2 0.5 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain TF_Zn_Ribbon PF08271.12 EEA24083.1 - 3.1 7.4 7.9 2.4 7.7 1.3 2.7 3 0 0 3 3 3 0 TFIIB zinc-binding DUF572 PF04502.13 EEA24084.1 - 6.8e-68 229.7 13.7 8.1e-68 229.5 13.7 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) TF_Zn_Ribbon PF08271.12 EEA24084.1 - 6.8 6.3 6.6 2.4 7.7 1.3 2.6 3 0 0 3 3 3 0 TFIIB zinc-binding FAT PF02259.23 EEA24085.1 - 1.8e-76 257.6 9.1 4.4e-76 256.4 9.1 1.8 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EEA24085.1 - 1.3e-35 123.5 0.2 3.6e-35 122.0 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EEA24085.1 - 0.00012 21.8 0.1 0.00029 20.6 0.1 1.8 1 0 0 1 1 1 1 FATC domain TPR_2 PF07719.17 EEA24085.1 - 0.045 13.9 3.5 1.6 9.1 0.4 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Ilar_coat PF01787.16 EEA24085.1 - 3.5 7.4 6.9 9.5 6.0 6.9 1.8 1 1 0 1 1 1 0 Ilarvirus coat protein AAA PF00004.29 EEA24086.1 - 1.7e-54 183.8 0.0 5.4e-39 133.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA24086.1 - 1.3e-09 37.7 0.0 2.6e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain CDC48_2 PF02933.17 EEA24086.1 - 2.4e-09 36.8 0.1 7.3e-08 32.1 0.0 2.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 EEA24086.1 - 5.7e-09 36.4 0.1 0.0002 21.7 0.0 4.0 2 2 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EEA24086.1 - 5.2e-08 33.2 0.0 0.0011 19.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EEA24086.1 - 8e-08 32.8 0.1 0.0042 17.5 0.0 3.3 3 0 0 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 EEA24086.1 - 6.7e-07 29.6 0.0 3.9e-05 23.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EEA24086.1 - 1.3e-06 27.9 0.1 0.0075 15.5 0.0 2.6 2 1 1 3 3 3 2 TIP49 P-loop domain RuvB_N PF05496.12 EEA24086.1 - 2.4e-06 27.4 0.1 0.037 13.8 0.1 2.8 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EEA24086.1 - 2.7e-06 26.9 0.1 0.0053 16.2 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EEA24086.1 - 3.7e-06 27.5 0.0 0.011 16.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EEA24086.1 - 4.8e-05 23.2 0.0 0.006 16.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA24086.1 - 5.4e-05 23.5 0.0 0.029 14.8 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 EEA24086.1 - 7.1e-05 22.8 0.0 0.0015 18.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EEA24086.1 - 8.6e-05 22.6 0.0 0.35 10.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 EEA24086.1 - 0.00014 21.9 0.0 0.00051 20.2 0.0 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain IstB_IS21 PF01695.17 EEA24086.1 - 0.00022 21.0 0.0 0.11 12.2 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_7 PF12775.7 EEA24086.1 - 0.00049 19.7 0.1 0.027 14.0 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_28 PF13521.6 EEA24086.1 - 0.0012 19.1 0.0 0.39 10.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EEA24086.1 - 0.0031 17.5 0.0 0.27 11.2 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EEA24086.1 - 0.0032 16.9 0.3 0.023 14.0 0.2 2.2 2 0 0 2 2 2 1 KaiC ABC_tran PF00005.27 EEA24086.1 - 0.0094 16.5 0.2 0.028 14.9 0.1 1.8 2 0 0 2 2 1 1 ABC transporter NB-ARC PF00931.22 EEA24086.1 - 0.011 15.0 0.1 1.5 7.9 0.1 2.7 2 1 0 2 2 2 0 NB-ARC domain Parvo_NS1 PF01057.17 EEA24086.1 - 0.015 14.4 0.0 0.47 9.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 EEA24086.1 - 0.016 15.1 1.5 24 4.7 0.0 3.8 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea KTI12 PF08433.10 EEA24086.1 - 0.021 14.3 0.0 2 7.8 0.0 2.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_3 PF07726.11 EEA24086.1 - 0.025 14.5 0.0 0.27 11.1 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EEA24086.1 - 0.027 14.3 0.1 0.56 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA24086.1 - 0.031 13.9 0.1 1.9 8.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EEA24086.1 - 0.047 13.6 0.2 6.9 6.5 0.1 2.7 3 0 0 3 3 2 0 NACHT domain AAA_17 PF13207.6 EEA24086.1 - 0.061 13.7 0.0 9.9 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EEA24086.1 - 0.08 12.6 0.0 0.62 9.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EEA24086.1 - 0.15 12.4 0.6 0.63 10.4 0.2 2.2 2 1 0 2 2 1 0 AAA domain DUF2075 PF09848.9 EEA24086.1 - 0.22 10.7 0.1 0.76 9.0 0.1 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) B56 PF01603.20 EEA24087.1 - 2.2e-191 636.3 2.1 2.7e-191 636.0 2.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Tau95 PF09734.9 EEA24088.1 - 5.9e-40 137.3 0.2 1.2e-39 136.3 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EEA24088.1 - 1.4e-27 96.4 0.3 8.1e-25 87.5 0.3 2.6 1 1 0 1 1 1 1 Tau95 Triple barrel domain DUF1350 PF07082.11 EEA24088.1 - 0.089 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) DAZAP2 PF11029.8 EEA24089.1 - 0.0096 16.8 0.0 0.026 15.5 0.0 1.7 1 1 0 1 1 1 1 DAZ associated protein 2 (DAZAP2) PfkB PF00294.24 EEA24090.1 - 1.7e-32 113.0 0.3 1e-31 110.4 0.3 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase MCM PF00493.23 EEA24091.1 - 8.3e-104 345.6 0.1 2.5e-103 344.0 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EEA24091.1 - 1.7e-36 124.8 1.0 3.2e-36 124.0 1.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA24091.1 - 3e-28 98.1 1.9 7.4e-28 96.8 1.9 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA24091.1 - 2.9e-15 56.7 0.2 7e-15 55.5 0.2 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EEA24091.1 - 1.3e-06 27.9 0.0 0.00096 18.6 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EEA24091.1 - 7e-05 22.8 0.0 0.00017 21.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EEA24091.1 - 0.00049 20.0 0.1 0.0019 18.1 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EEA24091.1 - 0.039 13.7 0.1 0.43 10.3 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain Vps54 PF07928.12 EEA24092.1 - 2.8e-51 173.5 0.1 8.3e-51 171.9 0.1 1.9 1 0 0 1 1 1 1 Vps54-like protein Vps54_N PF10475.9 EEA24092.1 - 9.8e-07 28.3 0.7 9.8e-07 28.3 0.7 2.2 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EEA24092.1 - 0.00012 22.0 0.8 0.00037 20.4 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) FliJ PF02050.16 EEA24092.1 - 0.0093 16.2 1.0 0.042 14.1 1.0 2.2 1 0 0 1 1 1 1 Flagellar FliJ protein Nnf1 PF03980.14 EEA24092.1 - 0.018 15.4 0.3 0.066 13.6 0.3 2.0 1 0 0 1 1 1 0 Nnf1 GPS2_interact PF15784.5 EEA24092.1 - 2.4 8.7 7.8 0.51 10.8 0.6 2.9 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Glycogen_syn PF05693.13 EEA24094.1 - 0 1154.3 0.0 0 1154.1 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EEA24094.1 - 2.4e-05 24.0 0.0 0.0027 17.3 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA24094.1 - 2.9e-05 24.5 0.0 0.031 14.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EEA24094.1 - 5.7e-05 23.2 0.3 0.00012 22.1 0.3 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EEA24094.1 - 0.0002 21.8 0.0 0.00043 20.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain ADH_zinc_N_2 PF13602.6 EEA24095.1 - 2.2e-15 57.9 0.1 6.3e-15 56.4 0.0 1.7 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EEA24095.1 - 9e-14 51.6 0.4 2.7e-13 50.0 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA24095.1 - 1.4e-09 37.8 1.1 2.3e-06 27.4 0.0 3.4 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EEA24095.1 - 0.00011 21.5 0.1 0.00023 20.5 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_2 PF16884.5 EEA24095.1 - 0.00041 20.2 0.3 0.0074 16.2 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase polyprenyl_synt PF00348.17 EEA24096.1 - 5.3e-90 300.9 0.0 6.6e-90 300.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Mistic PF11458.8 EEA24096.1 - 0.12 12.4 2.0 0.31 11.0 0.1 2.7 3 1 1 4 4 4 0 Membrane-integrating protein Mistic Sec2p PF06428.11 EEA24096.1 - 0.21 11.6 1.3 0.35 10.8 1.3 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p HTH_23 PF13384.6 EEA24097.1 - 9.8e-06 25.2 0.0 3.2e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 EEA24097.1 - 3.2e-05 24.5 0.1 7.2e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_5 PF01022.20 EEA24097.1 - 0.00024 20.9 0.8 0.074 12.9 0.1 2.2 2 0 0 2 2 2 2 Bacterial regulatory protein, arsR family TrmB PF01978.19 EEA24097.1 - 0.00025 20.9 0.1 0.0026 17.6 0.0 2.2 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Sigma70_r4_2 PF08281.12 EEA24097.1 - 0.00043 19.9 0.1 0.002 17.8 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_10 PF04967.12 EEA24097.1 - 0.0027 17.5 0.2 0.13 12.1 0.1 2.2 2 0 0 2 2 2 1 HTH DNA binding domain HTH_29 PF13551.6 EEA24097.1 - 0.0031 17.5 0.0 0.034 14.2 0.0 2.5 2 1 0 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.6 EEA24097.1 - 0.023 14.2 0.0 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Fe_dep_repress PF01325.19 EEA24097.1 - 0.024 14.9 0.2 0.34 11.1 0.0 2.3 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_28 PF13518.6 EEA24097.1 - 0.027 14.6 0.0 0.095 12.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_IclR PF09339.10 EEA24097.1 - 0.064 13.1 0.0 3 7.7 0.0 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain HRDC PF00570.23 EEA24097.1 - 0.11 12.5 0.0 0.32 11.0 0.0 1.7 2 0 0 2 2 2 0 HRDC domain HTH_17 PF12728.7 EEA24097.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain AA_permease_2 PF13520.6 EEA24099.1 - 5.4e-70 236.3 37.3 6.4e-70 236.1 37.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA24099.1 - 1.8e-21 76.3 32.5 2.3e-21 76.0 32.5 1.1 1 0 0 1 1 1 1 Amino acid permease TMEM52 PF14979.6 EEA24099.1 - 0.22 11.5 0.2 0.5 10.3 0.2 1.6 1 0 0 1 1 1 0 Transmembrane 52 DUF3188 PF11384.8 EEA24099.1 - 5.7 6.7 9.2 15 5.4 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) F-box-like PF12937.7 EEA24100.1 - 1.7e-08 34.2 2.2 6.6e-08 32.3 0.4 2.7 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 EEA24100.1 - 0.001 19.4 5.4 0.0041 17.5 0.6 3.3 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) ANAPC8 PF04049.13 EEA24101.1 - 1.6e-54 183.8 0.3 3.8e-54 182.6 0.0 1.9 2 0 0 2 2 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 EEA24101.1 - 1.1e-21 75.2 7.5 1.8e-05 24.6 0.0 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 EEA24101.1 - 6e-19 67.0 8.4 0.00018 21.2 0.0 7.9 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA24101.1 - 6.8e-17 60.2 18.1 0.096 12.9 0.1 9.2 9 1 0 9 9 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24101.1 - 7.4e-12 45.0 11.7 0.007 17.1 0.0 7.9 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 EEA24101.1 - 4.6e-10 39.9 12.2 0.13 12.8 0.0 8.0 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EEA24101.1 - 3.5e-09 36.7 12.9 0.00086 19.4 0.1 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA24101.1 - 1.7e-08 34.0 6.9 1.1e-06 28.2 0.3 4.5 4 1 1 5 5 5 2 TPR repeat TPR_12 PF13424.6 EEA24101.1 - 7.7e-08 32.5 9.2 1.9 8.8 0.0 6.2 6 1 0 6 6 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EEA24101.1 - 1.7e-07 31.1 0.4 3.5 8.2 0.0 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24101.1 - 4.1e-07 30.6 14.4 1.7e-05 25.4 0.0 6.5 6 2 1 7 7 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA24101.1 - 6.4e-05 23.1 14.4 0.23 11.7 1.0 6.2 6 1 2 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EEA24101.1 - 0.00012 21.5 7.8 0.00023 20.4 1.7 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EEA24101.1 - 0.00012 22.5 24.7 0.53 11.0 0.5 9.6 9 1 0 9 9 9 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA24101.1 - 0.00013 21.8 9.4 0.5 10.5 0.3 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EEA24101.1 - 0.1 12.5 10.6 6.3 6.8 0.7 6.3 6 0 0 6 6 5 0 Tetratricopeptide repeat CDC45 PF02724.14 EEA24101.1 - 0.14 10.4 3.5 0.21 9.8 3.5 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_ligase_A_M PF01068.21 EEA24102.1 - 2.3e-22 79.6 0.0 4.3e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EEA24103.1 - 6.6e-11 42.8 0.0 1.3e-10 41.9 0.0 1.5 1 1 0 1 1 1 1 DNA ligase N terminus DUF3449 PF11931.8 EEA24104.1 - 6.7e-77 257.4 1.1 6.7e-77 257.4 1.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EEA24104.1 - 6.1e-25 87.6 0.3 2.3e-24 85.7 0.0 2.1 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EEA24104.1 - 1.5e-15 56.7 1.1 4.1e-15 55.3 1.1 1.8 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 EEA24104.1 - 2.2e-08 34.2 2.4 7.6e-07 29.3 1.0 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA24104.1 - 3.3e-08 33.6 1.0 3.3e-08 33.6 1.0 2.5 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EEA24104.1 - 0.00078 19.7 0.7 0.0073 16.6 0.2 2.4 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) PRP9_N PF16958.5 EEA24104.1 - 0.0098 15.9 14.6 0.032 14.2 1.7 3.6 4 1 1 5 5 5 2 Pre-mRNA-splicing factor PRP9 N-terminus zf-LYAR PF08790.11 EEA24104.1 - 0.086 12.8 0.2 0.21 11.5 0.2 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2_4 PF13894.6 EEA24104.1 - 0.11 13.4 0.9 15 6.7 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA24104.1 - 3.3 8.3 4.3 9.9 6.8 0.5 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type DEAD PF00270.29 EEA24105.1 - 1.5e-41 142.1 0.2 2.7e-41 141.3 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA24105.1 - 1.5e-33 115.5 0.1 6.5e-33 113.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EEA24105.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA24105.1 - 0.0017 18.7 0.1 0.017 15.5 0.1 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EEA24105.1 - 0.0045 17.0 0.0 0.0087 16.1 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EEA24105.1 - 0.029 14.4 0.6 0.1 12.6 0.2 2.3 1 1 1 2 2 2 0 Flavivirus DEAD domain TniB PF05621.11 EEA24105.1 - 0.059 12.8 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Helicase_RecD PF05127.14 EEA24105.1 - 0.076 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 EEA24105.1 - 0.21 11.9 1.0 1.1 9.6 1.0 2.0 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 EEA24106.1 - 1.5e-41 142.1 0.2 2.7e-41 141.3 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA24106.1 - 1.5e-33 115.5 0.1 6.5e-33 113.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EEA24106.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA24106.1 - 0.0017 18.7 0.1 0.017 15.5 0.1 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EEA24106.1 - 0.0045 17.0 0.0 0.0087 16.1 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EEA24106.1 - 0.029 14.4 0.6 0.1 12.6 0.2 2.3 1 1 1 2 2 2 0 Flavivirus DEAD domain TniB PF05621.11 EEA24106.1 - 0.059 12.8 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Helicase_RecD PF05127.14 EEA24106.1 - 0.076 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 EEA24106.1 - 0.21 11.9 1.0 1.1 9.6 1.0 2.0 1 1 0 1 1 1 0 AAA domain Helicase_C PF00271.31 EEA24107.1 - 2e-33 115.1 0.0 3.3e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA24107.1 - 3.1e-20 72.7 0.0 6.6e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase TniB PF05621.11 EEA24107.1 - 0.04 13.3 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein tRNA-synt_1b PF00579.25 EEA24107.1 - 0.11 11.8 0.0 0.28 10.4 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) Melibiase_2 PF16499.5 EEA24108.1 - 1.8e-54 184.8 2.6 1.3e-37 129.6 0.2 2.5 2 0 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 EEA24108.1 - 1.1e-13 51.0 2.0 1.9e-12 47.1 0.1 3.0 3 0 0 3 3 3 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EEA24108.1 - 3.6e-05 22.9 0.0 7.7e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Melibiase GFA PF04828.14 EEA24109.1 - 0.00094 19.5 0.5 0.00094 19.5 0.5 1.8 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme zf-ribbon_3 PF13248.6 EEA24109.1 - 0.041 13.3 0.5 0.041 13.3 0.5 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Herpes_UL49_1 PF03117.14 EEA24109.1 - 0.41 9.9 3.2 0.54 9.5 3.2 1.1 1 0 0 1 1 1 0 UL49 family NPP1 PF05630.11 EEA24110.1 - 0.00025 21.2 4.1 0.0019 18.3 0.5 2.1 1 1 1 2 2 2 2 Necrosis inducing protein (NPP1) TrkH PF02386.16 EEA24111.1 - 1.8e-153 511.7 5.1 1.8e-153 511.7 5.1 2.1 2 0 0 2 2 2 2 Cation transport protein FAA_hydrolase PF01557.18 EEA24112.1 - 2.5e-64 216.9 0.0 4.4e-64 216.1 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_1 PF00561.20 EEA24112.1 - 3.3e-20 72.8 0.0 3.9e-15 56.2 0.0 2.7 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA24112.1 - 1.6e-17 64.8 0.0 2.4e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA24112.1 - 7.1e-17 61.5 0.0 1.2e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EEA24112.1 - 2e-08 34.6 0.0 3.7e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Ser_hydrolase PF06821.13 EEA24112.1 - 0.00036 20.5 0.1 0.0008 19.3 0.1 1.6 1 0 0 1 1 1 1 Serine hydrolase PGAP1 PF07819.13 EEA24112.1 - 0.00041 20.1 0.1 0.035 13.8 0.0 2.3 2 0 0 2 2 2 1 PGAP1-like protein Ndr PF03096.14 EEA24112.1 - 0.00058 18.7 0.0 0.00088 18.1 0.0 1.2 1 0 0 1 1 1 1 Ndr family Chlorophyllase2 PF12740.7 EEA24112.1 - 0.0049 15.8 0.1 0.0089 15.0 0.1 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_8 PF06259.12 EEA24112.1 - 0.027 14.1 1.0 0.094 12.3 0.2 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase Esterase PF00756.20 EEA24112.1 - 0.061 13.0 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Putative esterase PAF-AH_p_II PF03403.13 EEA24112.1 - 0.16 10.5 0.1 0.4 9.1 0.0 1.5 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II LCAT PF02450.15 EEA24112.1 - 0.25 10.5 0.0 0.41 9.8 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Glyco_hydro_16 PF00722.21 EEA24114.1 - 1.5e-08 34.3 0.2 2.5e-08 33.6 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 CN_hydrolase PF00795.22 EEA24115.1 - 2.1e-35 122.3 0.0 2.7e-35 122.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Dynamin_M PF01031.20 EEA24116.1 - 1.7e-102 342.5 0.1 3.4e-102 341.5 0.1 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EEA24116.1 - 2.1e-57 193.9 0.1 4.1e-57 192.9 0.1 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EEA24116.1 - 1.7e-30 105.0 6.6 1.7e-30 105.0 6.6 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EEA24116.1 - 3.5e-05 23.9 0.5 0.00018 21.5 0.5 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2226 PF09987.9 EEA24116.1 - 0.0013 18.2 0.4 0.18 11.1 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2226) FeoB_N PF02421.18 EEA24116.1 - 0.078 12.5 0.6 16 5.0 0.1 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_15 PF13175.6 EEA24116.1 - 1.1 8.9 5.7 6.1 6.5 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain ATP-synt_ab PF00006.25 EEA24117.1 - 3.2e-110 366.8 0.0 4.6e-110 366.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EEA24117.1 - 2.2e-47 159.9 0.1 4.2e-47 159.0 0.1 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EEA24117.1 - 5.3e-16 58.9 1.2 1e-15 58.0 1.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain WD40 PF00400.32 EEA24118.1 - 2.2e-22 78.9 17.0 0.00012 22.8 0.0 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24118.1 - 2.5e-11 43.7 2.3 0.26 11.6 0.0 4.6 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA24118.1 - 1.5e-07 31.5 0.3 7.7e-05 22.7 0.1 2.6 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA24118.1 - 1.5e-05 24.2 2.2 0.064 12.2 0.1 3.2 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EEA24118.1 - 0.0006 18.6 0.4 0.0086 14.8 0.1 2.2 2 0 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 EEA24118.1 - 0.037 13.3 0.1 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain IKI3 PF04762.12 EEA24118.1 - 0.04 11.9 0.3 2.2 6.2 0.0 2.2 2 0 0 2 2 2 0 IKI3 family Frtz PF11768.8 EEA24118.1 - 0.097 11.0 0.1 0.29 9.4 0.0 1.7 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_3 PF15911.5 EEA24118.1 - 0.14 12.2 0.2 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF4221 PF13970.6 EEA24118.1 - 0.26 10.8 0.6 0.97 8.9 0.1 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4221) PQQ_2 PF13360.6 EEA24119.1 - 0.077 12.6 1.2 1.5 8.4 1.1 2.8 2 1 0 2 2 2 0 PQQ-like domain ANAPC4_WD40 PF12894.7 EEA24119.1 - 0.11 12.8 0.0 36 4.8 0.0 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA24119.1 - 0.13 13.2 2.7 0.32 12.0 0.5 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat PQQ_3 PF13570.6 EEA24119.1 - 0.36 11.4 7.0 2 9.0 0.7 3.8 3 0 0 3 3 3 0 PQQ-like domain Proteasome PF00227.26 EEA24120.1 - 1.4e-55 187.7 0.1 1.9e-55 187.3 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA24120.1 - 5.9e-13 48.2 0.3 2.1e-12 46.5 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Terminase_5 PF06056.12 EEA24120.1 - 0.16 11.9 0.1 0.35 10.8 0.1 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) zf-RanBP PF00641.18 EEA24121.1 - 5.7e-21 73.5 10.5 8.4e-11 41.0 1.6 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EEA24121.1 - 7.7e-08 32.0 0.0 1.7e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 EEA24121.1 - 8.2e-07 29.7 0.0 1.2e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Exonuclease zf-ribbon_3 PF13248.6 EEA24121.1 - 1.3 8.5 5.1 2.5 7.6 0.3 3.0 3 0 0 3 3 3 0 zinc-ribbon domain DZR PF12773.7 EEA24121.1 - 4 7.5 7.6 60 3.8 7.7 2.4 1 1 0 1 1 1 0 Double zinc ribbon Cnd3 PF12719.7 EEA24122.1 - 1.8e-92 309.7 1.0 2.6e-91 305.9 0.2 2.3 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EEA24122.1 - 1.4e-06 28.6 11.4 0.0026 18.1 2.5 4.9 2 2 1 3 3 3 3 HEAT repeats HEAT_EZ PF13513.6 EEA24122.1 - 4.2e-05 23.9 3.4 0.12 13.0 0.0 4.8 5 0 0 5 5 5 2 HEAT-like repeat UNC45-central PF11701.8 EEA24122.1 - 0.00056 19.9 1.6 0.36 10.8 0.1 3.5 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central HEAT PF02985.22 EEA24122.1 - 0.0012 18.9 11.6 3.4 8.2 0.0 6.7 7 0 0 7 7 7 1 HEAT repeat Cnd1 PF12717.7 EEA24122.1 - 0.0021 18.1 1.7 0.11 12.5 0.0 3.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 DUF3558 PF12079.8 EEA24122.1 - 0.084 12.9 1.9 0.24 11.4 1.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) PALP PF00291.25 EEA24123.1 - 3e-69 233.7 0.2 3.5e-69 233.5 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Oxidored_molyb PF00174.19 EEA24124.1 - 3.1e-60 202.7 0.1 4.3e-60 202.2 0.1 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EEA24124.1 - 6.6e-24 84.5 0.0 1.3e-23 83.5 0.0 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Thymopoietin PF08198.11 EEA24124.1 - 0.067 12.8 0.0 5.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Thymopoietin protein Tim17 PF02466.19 EEA24125.1 - 1.8e-35 121.7 5.7 2.4e-35 121.3 5.7 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF4048 PF13257.6 EEA24126.1 - 8.2e-91 304.4 31.2 8.2e-91 304.4 31.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4048) IFP_35_N PF07334.13 EEA24126.1 - 3.4 7.8 7.3 0.55 10.4 2.8 2.0 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Bap31_Bap29_C PF18035.1 EEA24126.1 - 7.2 6.7 11.4 4.4 7.4 8.6 2.2 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4048 PF13257.6 EEA24127.1 - 6.5e-91 304.7 31.2 6.5e-91 304.7 31.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4048) Bap31_Bap29_C PF18035.1 EEA24127.1 - 1.4 9.0 8.6 3.9 7.6 8.5 1.8 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain IFP_35_N PF07334.13 EEA24127.1 - 1.6 8.9 6.5 0.49 10.5 2.8 2.0 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Pkinase PF00069.25 EEA24128.1 - 1.8e-69 234.1 0.0 2.4e-69 233.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24128.1 - 2.7e-46 158.0 0.0 4.7e-46 157.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA24128.1 - 3.4e-06 26.1 0.0 7.7e-06 24.9 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EEA24128.1 - 0.00087 18.7 0.0 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Glycos_transf_2 PF00535.26 EEA24128.1 - 0.12 12.2 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 FAD-oxidase_C PF02913.19 EEA24129.1 - 3.3e-61 207.1 0.0 4.7e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EEA24129.1 - 2.2e-37 127.9 0.5 4.3e-37 126.9 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain RmlD_sub_bind PF04321.17 EEA24130.1 - 1.4e-60 204.8 0.1 1.8e-60 204.5 0.1 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EEA24130.1 - 5.3e-25 88.3 0.0 7.1e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA24130.1 - 9.2e-11 41.4 0.2 3.4e-07 29.7 0.0 3.1 3 0 0 3 3 3 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EEA24130.1 - 1.3e-10 41.2 0.0 3.9e-10 39.7 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EEA24130.1 - 7.9e-09 35.1 0.3 3.6e-07 29.6 0.0 2.3 2 0 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 EEA24130.1 - 2.7e-07 29.9 0.0 2e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EEA24130.1 - 0.04 13.8 0.0 0.097 12.6 0.0 1.7 1 1 0 1 1 1 0 NAD(P)H-binding KR PF08659.10 EEA24130.1 - 0.34 10.8 1.2 2.6 7.9 0.2 2.6 3 0 0 3 3 3 0 KR domain PH PF00169.29 EEA24131.1 - 7.8e-05 23.1 0.4 0.00018 22.0 0.4 1.5 1 0 0 1 1 1 1 PH domain ASFV_L11L PF05293.11 EEA24132.1 - 0.27 11.6 7.7 1.3 9.4 0.2 3.2 3 1 1 4 4 4 0 African swine fever virus (ASFV) L11L protein Ank_2 PF12796.7 EEA24133.1 - 6.8e-47 158.0 0.0 3e-15 56.6 0.1 4.7 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA24133.1 - 8.8e-42 141.0 0.0 2.4e-08 34.4 0.0 5.7 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EEA24133.1 - 1.4e-40 136.0 0.0 3.7e-09 36.6 0.2 7.9 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EEA24133.1 - 2.6e-35 116.4 0.0 1.6e-06 28.0 0.1 8.0 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EEA24133.1 - 3.1e-32 110.2 0.0 6.9e-07 29.4 0.0 6.3 3 2 4 7 7 7 6 Ankyrin repeats (many copies) UPF0047 PF01894.17 EEA24134.1 - 2.3e-37 127.6 0.0 2.7e-37 127.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 zf-CHCC PF10276.9 EEA24135.1 - 8.9e-18 64.1 0.7 1.4e-17 63.4 0.7 1.3 1 0 0 1 1 1 1 Zinc-finger domain Tad_C PF09977.9 EEA24135.1 - 0.31 12.3 3.5 0.2 12.9 1.6 1.6 2 0 0 2 2 2 0 Putative Tad-like Flp pilus-assembly MPP6 PF10175.9 EEA24136.1 - 2.2e-05 24.9 3.4 0.0014 19.2 3.4 2.3 1 1 0 1 1 1 1 M-phase phosphoprotein 6 SNARE_assoc PF09335.11 EEA24137.1 - 8.2e-12 45.7 7.8 8.2e-12 45.7 7.8 2.1 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF1771 PF08590.10 EEA24138.1 - 1.5e-14 54.1 9.4 3.4e-14 53.0 9.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) zf_CCCH_4 PF18345.1 EEA24138.1 - 2.3e-08 33.8 9.6 1.7e-05 24.7 1.8 2.9 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 EEA24138.1 - 4.8e-08 32.7 2.0 0.0024 17.7 0.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Smr PF01713.21 EEA24138.1 - 3.1e-07 30.6 0.2 1e-06 29.0 0.2 1.9 1 0 0 1 1 1 1 Smr domain zf-CCCH_2 PF14608.6 EEA24138.1 - 4.5e-05 23.8 6.4 0.021 15.3 0.9 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EEA24138.1 - 0.00034 20.3 12.4 0.0019 17.9 1.7 3.1 2 1 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EEA24138.1 - 0.0032 17.7 2.8 1.6 9.0 0.1 2.4 1 1 1 2 2 2 2 Zinc-finger containing family CUE PF02845.16 EEA24138.1 - 0.0083 15.8 0.1 0.029 14.1 0.1 2.0 1 0 0 1 1 1 1 CUE domain Torus PF16131.5 EEA24138.1 - 0.11 13.2 3.4 3.2 8.5 0.9 2.6 1 1 1 2 2 2 0 Torus domain SapB_1 PF05184.15 EEA24138.1 - 0.25 11.4 7.9 2 8.5 0.1 3.9 4 0 0 4 4 4 0 Saposin-like type B, region 1 HpcH_HpaI PF03328.14 EEA24139.1 - 3.1e-45 154.0 0.2 8e-45 152.7 0.0 1.6 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EEA24139.1 - 5e-16 58.8 0.3 1.5e-07 30.9 0.0 2.0 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold SnoaL_3 PF13474.6 EEA24139.1 - 0.011 16.0 0.1 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 SnoaL-like domain PK PF00224.21 EEA24139.1 - 0.027 13.4 0.0 0.047 12.6 0.0 1.4 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain DUF846 PF05832.12 EEA24140.1 - 8.6e-50 168.4 9.8 1e-49 168.2 9.8 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TMEM220 PF15071.6 EEA24140.1 - 0.077 13.7 1.5 0.094 13.5 0.4 1.7 2 0 0 2 2 2 0 Transmembrane family 220, helix DUF4133 PF13571.6 EEA24140.1 - 0.55 10.6 3.3 1.5 9.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Dioxygenase_C PF00775.21 EEA24141.1 - 4.4e-41 140.3 0.0 5.8e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EEA24141.1 - 2.8e-24 84.8 0.0 4.7e-24 84.0 0.0 1.4 1 0 0 1 1 1 1 Catechol dioxygenase N terminus SpaA PF17802.1 EEA24141.1 - 0.015 15.6 0.0 0.024 15.0 0.0 1.3 1 0 0 1 1 1 0 Prealbumin-like fold domain CarboxypepD_reg PF13620.6 EEA24141.1 - 0.076 13.3 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain HALZ PF02183.18 EEA24142.1 - 0.0019 18.4 0.6 0.0019 18.4 0.6 2.9 2 1 1 3 3 3 1 Homeobox associated leucine zipper GAS PF13851.6 EEA24142.1 - 0.2 11.0 12.7 0.79 9.0 11.1 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding GIT_CC PF16559.5 EEA24142.1 - 6.5 6.7 7.2 0.76 9.7 0.1 2.8 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor ketoacyl-synt PF00109.26 EEA24143.1 - 2.3e-69 233.8 0.0 4.2e-69 232.9 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA24143.1 - 3.9e-58 196.3 1.2 1.9e-57 194.1 0.6 2.5 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EEA24143.1 - 2.6e-56 191.1 0.0 8.5e-56 189.4 0.0 1.8 2 0 0 2 2 2 1 Polyketide synthase dehydratase Condensation PF00668.20 EEA24143.1 - 3.7e-52 177.5 0.0 5.2e-52 177.0 0.0 1.2 1 0 0 1 1 1 1 Condensation domain Acyl_transf_1 PF00698.21 EEA24143.1 - 8.6e-52 176.6 0.0 1.5e-51 175.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA24143.1 - 3.8e-37 126.9 0.0 1.7e-36 124.8 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EEA24143.1 - 2.2e-28 98.9 0.0 5.3e-28 97.7 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EEA24143.1 - 4.2e-15 55.9 0.0 1.3e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA24143.1 - 5.4e-15 56.6 0.0 1.1e-13 52.4 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EEA24143.1 - 4.5e-10 39.3 0.1 1.6e-09 37.5 0.1 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24143.1 - 1.9e-07 30.9 0.3 4.3e-07 29.7 0.3 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EEA24143.1 - 6.6e-07 29.6 0.2 1.9e-06 28.2 0.2 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 EEA24143.1 - 0.0023 17.8 0.1 0.0049 16.7 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EEA24143.1 - 0.013 14.8 0.2 0.032 13.6 0.2 1.6 1 0 0 1 1 1 0 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 EEA24143.1 - 0.02 14.0 0.0 0.034 13.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EEA24143.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Lipocalin_5 PF13924.6 EEA24144.1 - 2e-41 141.1 0.0 2.3e-41 140.9 0.0 1.0 1 0 0 1 1 1 1 Lipocalin-like domain adh_short PF00106.25 EEA24145.1 - 1.6e-45 155.0 1.7 2.8e-35 121.6 0.4 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24145.1 - 5e-36 124.4 0.5 4.1e-27 95.3 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24145.1 - 0.00012 22.0 0.3 0.00024 21.0 0.0 1.7 2 0 0 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.19 EEA24145.1 - 0.00015 21.1 0.1 0.00045 19.6 0.0 1.7 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 EEA24145.1 - 0.0037 16.8 0.1 0.011 15.2 0.1 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Glyco_hydro_88 PF07470.13 EEA24146.1 - 4.8e-42 144.3 0.6 6.3e-42 143.9 0.6 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 DUF3602 PF12223.8 EEA24147.1 - 1.5e-24 86.4 4.0 1.4e-22 80.0 0.2 2.5 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 EEA24147.1 - 0.04 13.5 2.4 3 7.4 0.0 2.8 1 1 1 2 2 2 0 GTP1/OBG zf-U1 PF06220.12 EEA24148.1 - 1.3e-06 28.0 1.0 1.8e-06 27.6 1.0 1.2 1 0 0 1 1 1 1 U1 zinc finger TRP PF06011.12 EEA24149.1 - 2.9e-163 543.6 28.4 4.2e-163 543.0 28.4 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EEA24149.1 - 2.5e-43 147.8 1.9 3.9e-43 147.1 1.9 1.3 1 0 0 1 1 1 1 ML-like domain Ac76 PF05814.11 EEA24149.1 - 0.46 10.5 8.0 3.6 7.7 1.1 3.2 2 1 1 3 3 3 0 Orf76 (Ac76) SLATT_fungal PF18142.1 EEA24149.1 - 6.3 6.8 6.8 2.7 8.0 2.3 2.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain O-ag_pol_Wzy PF14296.6 EEA24151.1 - 0.025 13.2 0.5 0.035 12.8 0.5 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy Hydrolase PF00702.26 EEA24152.1 - 5.1e-17 62.9 0.0 1.4e-13 51.6 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA24152.1 - 2.3e-15 57.1 0.0 7.3e-15 55.5 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA24152.1 - 4.3e-07 29.9 0.0 1.4e-06 28.3 0.0 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EEA24152.1 - 0.0014 19.1 0.1 0.0064 16.9 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 EEA24152.1 - 0.0075 15.9 0.0 0.19 11.3 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase Hydrolase_6 PF13344.6 EEA24152.1 - 0.13 12.4 0.0 3.3 7.9 0.0 2.5 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase zf-CCHC_3 PF13917.6 EEA24153.1 - 0.019 14.9 0.6 0.019 14.9 0.6 4.0 3 1 1 4 4 4 0 Zinc knuckle zf-CCHC PF00098.23 EEA24153.1 - 0.51 10.5 0.0 0.51 10.5 0.0 5.1 5 0 0 5 5 5 0 Zinc knuckle Cys_rich_CPXG PF14255.6 EEA24153.1 - 1.2 9.1 5.9 9.1 6.3 1.0 2.7 2 0 0 2 2 2 0 Cysteine-rich CPXCG DUF3292 PF11696.8 EEA24153.1 - 2.4 6.4 5.0 5.3 5.3 5.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) ORMDL PF04061.14 EEA24154.1 - 4.9e-56 188.3 5.3 6.1e-56 188.0 5.3 1.1 1 0 0 1 1 1 1 ORMDL family ORMDL PF04061.14 EEA24155.1 - 3.9e-58 195.1 5.0 4.7e-58 194.8 5.0 1.1 1 0 0 1 1 1 1 ORMDL family PBP1_TM PF14812.6 EEA24156.1 - 5.9 7.3 11.9 1.7 9.1 5.7 2.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CH PF00307.31 EEA24157.1 - 2.2e-14 53.6 0.0 4.5e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EEA24157.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain DUF4677 PF15726.5 EEA24157.1 - 0.38 10.9 2.0 0.61 10.2 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) NDUFA12 PF05071.16 EEA24158.1 - 1.4e-12 48.2 7.7 3.3e-12 47.1 7.7 1.8 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 EMP24_GP25L PF01105.24 EEA24162.1 - 1.6e-40 139.0 0.0 1.8e-40 138.9 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 EEA24162.1 - 0.11 10.7 0.9 0.14 10.3 0.9 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF4470 PF14737.6 EEA24163.1 - 2.1e-26 91.9 0.2 3.6e-26 91.2 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 EEA24163.1 - 1.3e-08 34.8 9.1 1.3e-08 34.8 9.1 2.1 3 0 0 3 3 3 1 MYND finger Sugar_tr PF00083.24 EEA24164.1 - 2.7e-76 257.3 13.8 3.1e-76 257.1 13.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24164.1 - 4.3e-20 71.9 13.6 4.3e-20 71.9 13.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF998 PF06197.13 EEA24164.1 - 0.015 14.9 0.3 0.015 14.9 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF998) DUF4396 PF14342.6 EEA24165.1 - 5.9e-46 156.3 3.4 7.4e-46 156.0 3.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) YabA PF06156.13 EEA24165.1 - 0.14 12.8 0.1 0.22 12.2 0.1 1.3 1 0 0 1 1 1 0 Initiation control protein YabA Yeast_MT PF11403.8 EEA24165.1 - 0.61 10.7 10.4 0.43 11.2 6.0 2.2 2 0 0 2 2 2 0 Yeast metallothionein Sugar_tr PF00083.24 EEA24166.1 - 4.6e-72 243.3 19.3 5.6e-72 243.0 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24166.1 - 5.4e-23 81.5 31.7 5.4e-23 81.5 31.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1485 PF07364.12 EEA24167.1 - 1.2e-105 353.0 0.5 1.5e-105 352.6 0.5 1.1 1 0 0 1 1 1 1 Metallopeptidase family M81 MlrC_C PF07171.12 EEA24167.1 - 2.6e-59 200.4 0.5 7e-59 199.0 0.3 1.8 2 0 0 2 2 2 1 MlrC C-terminus UPF0029 PF01205.19 EEA24168.1 - 1.6e-34 118.4 0.1 3.6e-34 117.2 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EEA24168.1 - 2.9e-08 34.0 0.0 4.7e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 RWD domain Cytokin_check_N PF10407.9 EEA24168.1 - 0.17 11.8 0.0 0.45 10.5 0.0 1.6 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Glyco_hydro_61 PF03443.14 EEA24169.1 - 0.084 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 61 Ribosomal_L4 PF00573.22 EEA24170.1 - 1.9e-38 132.1 0.4 2.6e-38 131.7 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EEA24170.1 - 1.1e-30 105.5 1.5 2.7e-30 104.2 1.5 1.7 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain Zn_clus PF00172.18 EEA24171.1 - 3.9e-08 33.3 11.6 7.1e-08 32.4 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3395 PF11875.8 EEA24172.1 - 9.9e-42 142.5 0.6 2.1e-41 141.4 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EEA24172.1 - 1.3e-17 63.6 0.1 2.4e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain PRR20 PF15708.5 EEA24173.1 - 0.43 10.5 8.3 3.2 7.6 0.3 2.2 2 0 0 2 2 2 0 Proline-rich protein family 20 AF-4 PF05110.13 EEA24173.1 - 0.68 7.9 30.0 0.78 7.7 30.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ank_2 PF12796.7 EEA24174.1 - 9.7e-28 96.6 0.8 4.2e-07 30.4 0.5 6.3 4 2 3 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA24174.1 - 5.5e-23 81.0 6.5 3e-05 24.5 0.1 8.5 7 2 3 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EEA24174.1 - 3.6e-22 77.8 8.9 0.0017 18.8 0.3 9.7 10 0 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.6 EEA24174.1 - 2.9e-19 67.1 6.7 0.25 12.0 0.1 11.0 10 2 0 10 10 10 4 Ankyrin repeat Ank_5 PF13857.6 EEA24174.1 - 5.6e-18 64.8 3.9 2.7e-08 33.9 1.0 7.5 8 0 0 8 8 8 4 Ankyrin repeats (many copies) SKIP_SNW PF02731.15 EEA24175.1 - 4e-72 241.1 7.0 4e-72 241.1 7.0 2.3 2 0 0 2 2 2 1 SKIP/SNW domain SR-25 PF10500.9 EEA24175.1 - 0.44 10.1 23.5 0.8 9.3 23.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM60A PF15396.6 EEA24175.1 - 1.2 9.1 8.7 2.7 7.9 8.7 1.6 1 0 0 1 1 1 0 Protein Family FAM60A Sugar_tr PF00083.24 EEA24176.1 - 3.1e-05 23.0 4.0 5e-05 22.3 4.0 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter ACT_7 PF13840.6 EEA24177.1 - 4.2e-27 93.7 0.1 5.1e-19 67.8 0.0 3.5 3 0 0 3 3 3 3 ACT domain Pep1_7 PF17232.2 EEA24177.1 - 0.12 12.9 0.2 0.54 10.7 0.0 2.1 2 0 0 2 2 2 0 Elicitor peptide 1-7 SRAP PF02586.14 EEA24178.1 - 1e-82 276.9 0.3 1.6e-82 276.3 0.3 1.3 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) TPR_10 PF13374.6 EEA24179.1 - 4.2e-06 26.4 0.7 0.16 11.9 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA24179.1 - 0.00091 19.7 5.2 0.011 16.2 0.5 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA24179.1 - 0.0024 17.8 3.0 15 5.9 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA24179.1 - 0.0075 16.1 0.5 1.2 9.1 0.4 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24179.1 - 0.014 15.7 10.7 0.43 10.9 0.0 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24179.1 - 0.02 15.7 6.2 29 5.8 0.1 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 EEA24179.1 - 0.02 15.5 1.3 2 9.3 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA24179.1 - 0.094 12.9 9.9 5.9 7.3 0.6 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat WD40 PF00400.32 EEA24180.1 - 1.3e-45 152.5 22.5 1.6e-09 38.2 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24180.1 - 4.4e-10 39.7 0.2 0.058 13.7 0.0 4.4 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA24180.1 - 2.6e-06 26.4 6.3 0.071 11.8 0.1 4.7 2 1 3 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 EEA24180.1 - 0.0013 18.7 0.0 1.2 9.0 0.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA24180.1 - 0.0015 17.6 0.1 7.5 5.4 0.0 3.8 2 2 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EEA24180.1 - 0.0058 15.2 0.0 0.61 8.6 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 EEA24180.1 - 0.013 15.4 0.2 22 5.1 0.0 4.4 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EEA24180.1 - 0.014 14.8 0.0 0.83 8.9 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain Sdh5 PF03937.16 EEA24181.1 - 9.9e-25 86.3 0.5 1.9e-24 85.4 0.5 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Zn_clus PF00172.18 EEA24183.1 - 9.9e-09 35.2 12.2 1.7e-08 34.4 12.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IMUP PF15761.5 EEA24183.1 - 1.1 10.0 4.3 2 9.1 4.3 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein Aminotran_1_2 PF00155.21 EEA24184.1 - 1.2e-08 34.5 0.0 2.2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II EarP PF10093.9 EEA24184.1 - 0.14 11.3 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP LCCL PF03815.19 EEA24185.1 - 4.4e-22 78.0 0.3 7.2e-22 77.3 0.3 1.3 1 0 0 1 1 1 1 LCCL domain DUF1282 PF06930.12 EEA24185.1 - 4.5 7.0 11.7 0.44 10.3 6.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1282) WD40 PF00400.32 EEA24187.1 - 1.5e-23 82.6 15.2 0.00021 22.0 0.3 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24187.1 - 3.4e-13 49.7 0.7 0.083 13.2 0.1 5.1 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA24187.1 - 6e-05 23.0 0.0 0.69 9.8 0.0 3.5 3 1 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 EEA24187.1 - 0.00022 21.0 1.9 0.14 12.1 0.0 3.7 4 0 0 4 4 4 1 PQQ enzyme repeat Coatomer_WDAD PF04053.14 EEA24187.1 - 0.0037 16.4 0.1 0.019 14.1 0.0 1.9 2 0 0 2 2 2 1 Coatomer WD associated region DUF5046 PF16465.5 EEA24187.1 - 0.0047 16.4 0.3 0.049 13.1 0.2 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF5046) VID27 PF08553.10 EEA24187.1 - 0.014 14.5 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 EEA24187.1 - 0.062 12.3 0.3 6.1 5.7 0.0 3.1 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EEA24187.1 - 0.59 10.7 3.9 1.7 9.2 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.32 EEA24188.1 - 1.5e-23 82.6 15.2 0.00021 22.0 0.3 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24188.1 - 3.4e-13 49.7 0.7 0.083 13.2 0.1 5.1 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA24188.1 - 6e-05 23.0 0.0 0.69 9.8 0.0 3.5 3 1 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 EEA24188.1 - 0.00022 21.0 1.9 0.14 12.1 0.0 3.7 4 0 0 4 4 4 1 PQQ enzyme repeat Coatomer_WDAD PF04053.14 EEA24188.1 - 0.0037 16.4 0.1 0.019 14.1 0.0 1.9 2 0 0 2 2 2 1 Coatomer WD associated region DUF5046 PF16465.5 EEA24188.1 - 0.0047 16.4 0.3 0.049 13.1 0.2 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF5046) VID27 PF08553.10 EEA24188.1 - 0.014 14.5 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 EEA24188.1 - 0.062 12.3 0.3 6.1 5.7 0.0 3.1 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EEA24188.1 - 0.59 10.7 3.9 1.7 9.2 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain Septin PF00735.18 EEA24189.1 - 1.1e-114 382.5 0.2 1.8e-114 381.8 0.2 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EEA24189.1 - 1.6e-07 31.4 0.0 3.6e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA24189.1 - 5.5e-06 26.4 1.2 5.5e-05 23.1 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EEA24189.1 - 9.7e-05 22.0 8.0 9.8e-05 22.0 0.5 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EEA24189.1 - 0.00072 19.8 0.6 0.0021 18.4 0.0 2.1 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 EEA24189.1 - 0.0026 17.3 0.1 0.0051 16.3 0.1 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 EEA24189.1 - 0.0037 17.5 0.2 0.0084 16.3 0.2 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EEA24189.1 - 0.0057 16.0 0.0 0.011 15.0 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 EEA24189.1 - 0.0082 15.2 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FOXP-CC PF16159.5 EEA24189.1 - 0.013 16.1 2.2 0.024 15.3 0.9 2.2 1 1 1 2 2 1 0 FOXP coiled-coil domain AAA_24 PF13479.6 EEA24189.1 - 0.014 15.1 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA24189.1 - 0.028 14.8 0.6 0.084 13.2 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain KAP_NTPase PF07693.14 EEA24189.1 - 0.035 13.4 0.1 0.05 12.8 0.1 1.6 1 1 0 1 1 1 0 KAP family P-loop domain Ras PF00071.22 EEA24189.1 - 0.036 13.6 1.1 0.13 11.8 0.5 2.2 2 1 0 2 2 2 0 Ras family T2SSE PF00437.20 EEA24189.1 - 0.041 12.9 0.6 0.079 12.0 0.1 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 EEA24189.1 - 0.056 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EEA24189.1 - 0.064 12.8 0.3 0.59 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EEA24189.1 - 0.084 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EEA24189.1 - 0.089 12.5 0.4 4.1 7.1 0.4 2.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EEA24189.1 - 0.091 13.3 1.4 0.18 12.3 0.0 2.1 2 1 0 2 2 2 0 ABC transporter FtsK_SpoIIIE PF01580.18 EEA24189.1 - 0.091 12.1 0.4 0.19 11.0 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 EEA24189.1 - 0.12 12.7 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Casc1_N PF15927.5 EEA24189.1 - 0.13 12.0 10.9 0.3 10.7 10.9 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus ATP_bind_1 PF03029.17 EEA24189.1 - 0.2 11.4 0.9 12 5.6 0.1 2.8 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EEA24189.1 - 0.76 9.8 7.4 3.6 7.6 0.1 3.1 2 1 1 3 3 3 0 Dynamin family AAA_11 PF13086.6 EEA24189.1 - 4.8 6.9 7.6 25 4.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain DegS PF05384.11 EEA24189.1 - 7.5 6.0 16.0 2.7 7.5 9.5 2.8 2 1 1 3 3 3 0 Sensor protein DegS APG6_N PF17675.1 EEA24189.1 - 8.4 6.9 15.3 2 8.9 10.6 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region WD40 PF00400.32 EEA24190.1 - 6e-38 128.2 17.4 8.7e-08 32.7 0.0 11.6 13 0 0 13 13 13 6 WD domain, G-beta repeat Utp12 PF04003.12 EEA24190.1 - 4.9e-28 97.6 0.1 7.8e-28 96.9 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EEA24190.1 - 5.3e-20 71.5 0.1 0.35 11.2 0.1 9.9 4 2 5 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA24190.1 - 5.8e-10 38.7 1.7 0.074 12.0 0.0 5.6 3 3 4 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EEA24190.1 - 0.00023 21.1 7.0 0.12 12.3 0.2 5.6 5 3 2 7 7 7 2 Eukaryotic translation initiation factor eIF2A Gmad1 PF10647.9 EEA24190.1 - 0.0003 20.6 3.5 0.018 14.8 0.0 3.5 2 1 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain Utp21 PF04192.12 EEA24190.1 - 0.00052 19.6 0.0 0.00084 18.9 0.0 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain Nup160 PF11715.8 EEA24190.1 - 0.00063 18.5 7.8 2.6 6.6 0.0 5.2 3 3 3 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EEA24190.1 - 0.00094 17.8 0.0 0.012 14.2 0.0 2.5 3 1 0 3 3 3 1 Cytochrome D1 heme domain WD40_like PF17005.5 EEA24190.1 - 0.014 14.7 0.0 2 7.7 0.0 3.6 4 0 0 4 4 4 0 WD40-like domain Coatomer_WDAD PF04053.14 EEA24190.1 - 0.17 10.9 0.0 0.93 8.5 0.0 2.2 2 0 0 2 2 2 0 Coatomer WD associated region PQQ_3 PF13570.6 EEA24190.1 - 0.31 11.6 9.7 19 5.9 0.0 6.3 8 0 0 8 8 8 0 PQQ-like domain Cyclase PF04199.13 EEA24191.1 - 4.1e-13 49.8 0.0 5.3e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Zn_clus PF00172.18 EEA24192.1 - 2.9e-09 36.9 7.2 5.9e-09 35.9 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA24192.1 - 1.8e-06 27.2 0.0 6.8e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Cu-oxidase PF00394.22 EEA24193.1 - 3.2e-41 141.1 5.3 3.6e-39 134.4 0.3 3.5 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EEA24193.1 - 2.4e-39 134.0 1.3 2.4e-39 134.0 1.3 4.2 3 1 1 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA24193.1 - 5.1e-37 126.7 14.6 4.2e-35 120.5 4.1 3.2 3 1 0 3 3 3 2 Multicopper oxidase DUF1100 PF06500.11 EEA24194.1 - 4.2e-10 39.0 0.0 7e-10 38.3 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S9 PF00326.21 EEA24194.1 - 1e-07 31.7 0.0 8.8e-07 28.6 0.0 2.5 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EEA24194.1 - 0.00018 21.2 0.0 0.0075 15.9 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA24194.1 - 0.00041 21.0 0.0 0.00059 20.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA24194.1 - 0.001 18.4 0.0 0.011 15.0 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 EEA24194.1 - 0.0012 18.5 0.0 0.0022 17.7 0.0 1.5 1 1 0 1 1 1 1 Putative esterase DLH PF01738.18 EEA24194.1 - 0.0083 15.7 0.0 0.02 14.4 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EEA24194.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.4 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1100 PF06500.11 EEA24195.1 - 2e-06 26.9 0.0 3.6e-06 26.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S9 PF00326.21 EEA24195.1 - 6.1e-06 25.9 0.1 4.1e-05 23.2 0.1 2.3 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EEA24195.1 - 0.00056 20.6 0.4 0.00091 19.9 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EEA24195.1 - 0.0009 19.0 0.1 0.002 17.8 0.1 1.6 1 1 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 EEA24195.1 - 0.0034 17.1 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA24195.1 - 0.0042 16.4 0.0 0.0068 15.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 EEA24195.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.8 1 1 0 1 1 1 0 Dienelactone hydrolase family Ndr PF03096.14 EEA24195.1 - 0.21 10.2 0.0 0.46 9.1 0.0 1.5 2 0 0 2 2 2 0 Ndr family adh_short_C2 PF13561.6 EEA24196.1 - 3.1e-57 193.8 0.2 5.6e-57 193.0 0.2 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA24196.1 - 7.9e-48 162.5 0.6 1e-47 162.2 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA24196.1 - 7.6e-20 71.6 0.2 9.9e-20 71.2 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA24196.1 - 0.00016 21.2 0.1 0.00022 20.7 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA24196.1 - 0.0089 15.2 0.0 0.011 14.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Scytalone_dh PF02982.14 EEA24197.1 - 2.3e-85 284.2 3.5 2.7e-85 284.1 3.5 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EEA24197.1 - 1.4e-07 31.7 1.7 1.7e-07 31.4 1.7 1.1 1 0 0 1 1 1 1 SnoaL-like domain Scytalone_dh PF02982.14 EEA24198.1 - 3e-85 283.9 3.5 3.5e-85 283.7 3.5 1.1 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EEA24198.1 - 1.8e-07 31.4 1.7 2.2e-07 31.0 1.7 1.1 1 0 0 1 1 1 1 SnoaL-like domain SGL PF08450.12 EEA24199.1 - 3e-05 23.7 0.1 4.4e-05 23.2 0.1 1.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Peptidase_S31 PF05578.12 EEA24199.1 - 0.024 14.2 0.0 0.1 12.1 0.0 1.8 1 1 1 2 2 2 0 Pestivirus NS3 polyprotein peptidase S31 Cu-oxidase_3 PF07732.15 EEA24200.1 - 9.3e-39 132.1 3.0 2.1e-38 131.0 3.0 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA24200.1 - 4.2e-27 94.6 7.2 2.3e-21 76.0 0.0 4.1 4 1 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 EEA24200.1 - 1.7e-14 54.3 0.1 4.9e-14 52.7 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase AraC_binding PF02311.19 EEA24201.1 - 0.042 13.8 0.0 0.042 13.8 0.0 1.1 1 0 0 1 1 1 0 AraC-like ligand binding domain Helicase_C PF00271.31 EEA24202.1 - 2.7e-10 40.6 0.1 5.3e-09 36.4 0.1 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA24202.1 - 0.0052 16.6 0.0 0.009 15.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SH3_17 PF18350.1 EEA24205.1 - 0.00062 19.6 0.5 0.001 18.9 0.3 1.4 1 1 0 1 1 1 1 Restriction endonuclease SH3 domain DUF1241 PF06840.11 EEA24205.1 - 0.052 13.2 0.1 0.064 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) SAT PF16073.5 EEA24206.1 - 3.4e-82 275.8 0.5 2.8e-81 272.8 0.1 2.4 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 EEA24206.1 - 5e-81 272.0 0.0 8.4e-81 271.3 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EEA24206.1 - 4e-38 131.7 0.0 6e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA24206.1 - 3.2e-36 123.9 1.1 7.9e-36 122.7 1.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EEA24206.1 - 6.5e-24 84.1 4.5 1.5e-11 44.5 0.5 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thioesterase PF00975.20 EEA24206.1 - 4.7e-23 82.5 0.0 3e-22 79.9 0.0 2.4 2 0 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 EEA24206.1 - 2.4e-15 56.6 0.0 3.8e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EEA24206.1 - 8.4e-05 22.0 0.0 0.00029 20.3 0.0 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain Abhydrolase_6 PF12697.7 EEA24206.1 - 0.00075 20.2 0.1 0.019 15.6 0.0 2.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family KAsynt_C_assoc PF16197.5 EEA24206.1 - 0.014 15.9 0.0 0.032 14.7 0.0 1.6 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension DUF2974 PF11187.8 EEA24206.1 - 0.017 14.7 0.0 0.07 12.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EEA24206.1 - 0.13 11.5 0.0 16 4.7 0.0 2.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 SH3_2 PF07653.17 EEA24207.1 - 6.2e-08 32.2 0.1 2e-07 30.6 0.1 2.0 1 0 0 1 1 1 1 Variant SH3 domain Transglut_core PF01841.19 EEA24207.1 - 1.7e-07 31.6 0.0 5.2e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_1 PF00018.28 EEA24207.1 - 4.1e-07 29.5 0.6 4.5e-06 26.2 0.0 2.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EEA24207.1 - 0.0076 16.1 1.2 0.049 13.5 0.1 2.7 3 0 0 3 3 3 1 Variant SH3 domain DHHA2 PF02833.14 EEA24208.1 - 1.5e-36 125.7 0.1 2.7e-36 124.9 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EEA24208.1 - 5e-05 23.5 0.0 0.00015 22.0 0.0 1.9 1 1 0 1 1 1 1 DHH family PLU-1 PF08429.11 EEA24209.1 - 3.2e-109 365.2 21.4 1.1e-104 350.3 19.0 2.2 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 EEA24209.1 - 6.9e-44 148.9 0.4 2.1e-43 147.3 0.3 2.0 2 0 0 2 2 1 1 JmjC domain, hydroxylase ARID PF01388.21 EEA24209.1 - 3.2e-22 79.0 0.1 1e-21 77.4 0.1 2.0 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 EEA24209.1 - 2.6e-17 62.5 1.9 6.7e-17 61.1 1.9 1.8 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 EEA24209.1 - 2.1e-15 56.4 32.2 5.3e-09 35.8 8.1 3.6 3 0 0 3 3 3 2 PHD-finger zf-C5HC2 PF02928.16 EEA24209.1 - 1.3e-12 47.9 8.0 3.8e-12 46.4 8.0 1.9 1 0 0 1 1 1 1 C5HC2 zinc finger Prok-RING_1 PF14446.6 EEA24209.1 - 0.0011 18.9 3.7 0.0011 18.9 3.7 3.0 2 1 1 3 3 3 1 Prokaryotic RING finger family 1 C1_2 PF03107.16 EEA24209.1 - 0.018 15.4 0.8 0.018 15.4 0.8 4.7 4 1 1 5 5 4 0 C1 domain zf-PHD-like PF15446.6 EEA24209.1 - 0.021 14.4 7.3 0.092 12.4 0.9 2.7 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain ORC4_C PF14629.6 EEA24209.1 - 0.061 12.7 0.3 2.6 7.4 0.0 2.9 3 0 0 3 3 3 0 Origin recognition complex (ORC) subunit 4 C-terminus C1_1 PF00130.22 EEA24209.1 - 0.065 13.1 17.1 0.053 13.4 1.0 3.2 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RanBP PF00641.18 EEA24209.1 - 0.21 10.9 8.4 2.2 7.7 0.5 2.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others PHD_4 PF16866.5 EEA24209.1 - 0.59 10.3 26.0 0.044 13.9 6.2 3.1 3 0 0 3 3 3 0 PHD-finger zf-HC5HC2H PF13771.6 EEA24209.1 - 2.2 8.6 17.8 0.13 12.5 1.5 3.2 3 0 0 3 3 2 0 PHD-like zinc-binding domain PHD_2 PF13831.6 EEA24209.1 - 5.7 6.6 12.4 0.071 12.7 1.8 2.6 2 0 0 2 2 2 0 PHD-finger Rubredoxin PF00301.20 EEA24209.1 - 6.3 6.9 8.7 6.4 6.9 0.2 4.0 3 0 0 3 3 3 0 Rubredoxin GIY-YIG PF01541.24 EEA24210.1 - 2.3e-14 53.4 0.0 4.4e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain FANCL_C PF11793.8 EEA24210.1 - 0.00017 21.7 1.9 0.00032 20.8 1.9 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain zf-HC5HC2H PF13771.6 EEA24210.1 - 0.00028 21.1 0.4 0.0006 20.0 0.4 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain Prok-RING_1 PF14446.6 EEA24210.1 - 0.004 17.0 3.6 0.004 17.0 3.6 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-HC5HC2H_2 PF13832.6 EEA24210.1 - 0.0062 16.7 0.6 0.015 15.4 0.6 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-RING_9 PF13901.6 EEA24210.1 - 0.016 15.2 1.3 0.028 14.4 1.3 1.4 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon C1_1 PF00130.22 EEA24210.1 - 0.022 14.7 2.5 0.022 14.7 2.5 1.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 EEA24210.1 - 0.025 14.9 5.4 0.044 14.1 5.4 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING-like PF08746.11 EEA24210.1 - 0.034 14.5 4.7 0.11 12.9 4.8 1.9 1 1 0 1 1 1 0 RING-like domain T5orf172 PF10544.9 EEA24210.1 - 0.11 13.0 0.0 0.26 11.9 0.0 1.7 1 0 0 1 1 1 0 T5orf172 domain PHD PF00628.29 EEA24210.1 - 0.12 12.3 6.5 0.28 11.1 6.5 1.7 1 1 0 1 1 1 0 PHD-finger Thymidylate_kin PF02223.17 EEA24211.1 - 3.9e-48 163.6 0.0 4.5e-48 163.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase KTI12 PF08433.10 EEA24211.1 - 0.065 12.7 0.0 0.17 11.3 0.0 1.6 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_28 PF13521.6 EEA24211.1 - 0.14 12.4 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain TGT PF01702.18 EEA24212.1 - 8.1e-64 216.0 0.0 1e-63 215.6 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase MTHFR PF02219.17 EEA24213.1 - 1.3e-100 336.4 0.0 1.2e-99 333.3 0.0 2.0 2 0 0 2 2 2 1 Methylenetetrahydrofolate reductase FLILHELTA PF10306.9 EEA24214.1 - 5.9e-30 103.5 0.0 1e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 EEA24214.1 - 0.001 19.6 0.5 0.0014 19.1 0.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) NDK PF00334.19 EEA24215.1 - 3.3e-54 182.6 0.0 3.8e-54 182.4 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Glyco_hydro_31 PF01055.26 EEA24216.1 - 1.3e-137 459.6 12.2 1.9e-137 459.1 12.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EEA24216.1 - 1.4e-26 92.6 0.9 3.7e-26 91.2 0.2 2.2 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EEA24216.1 - 2.5e-06 27.6 0.4 7.1e-06 26.2 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) PQ-loop PF04193.14 EEA24217.1 - 1.2e-19 69.8 6.5 5e-12 45.4 0.0 2.7 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 EEA24217.1 - 7.6e-05 23.6 1.7 0.00012 22.9 1.2 1.6 1 1 0 1 1 1 1 ER lumen protein retaining receptor NMT1_2 PF13379.6 EEA24218.1 - 0.003 17.3 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 NMT1-like family NMT1_3 PF16868.5 EEA24218.1 - 0.07 12.5 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 NMT1-like family CdhD PF03599.16 EEA24218.1 - 0.2 10.3 0.2 0.3 9.8 0.2 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit DUF4139 PF13598.6 EEA24219.1 - 1.1e-34 120.0 0.0 1.1e-34 120.0 0.0 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 EEA24219.1 - 1.2e-23 83.4 3.0 1.2e-23 83.4 3.0 3.6 4 1 0 4 4 4 1 N-terminal domain of unknown function (DUF4140) CIA30 PF08547.12 EEA24219.1 - 0.078 13.0 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Complex I intermediate-associated protein 30 (CIA30) DUF3987 PF13148.6 EEA24219.1 - 0.5 9.3 8.5 0.41 9.6 5.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Halogen_Hydrol PF10112.9 EEA24219.1 - 0.64 10.0 7.3 7.8 6.5 2.9 2.4 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein NUDIX PF00293.28 EEA24220.1 - 1.9e-18 66.8 0.1 4e-18 65.7 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EEA24220.1 - 4e-12 46.7 0.0 8.4e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EEA24220.1 - 8.4e-07 28.5 1.3 1.4e-06 27.8 1.3 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain adh_short PF00106.25 EEA24221.1 - 6.6e-31 107.3 0.0 4.7e-30 104.5 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24221.1 - 6.2e-28 97.9 0.0 5.8e-26 91.5 0.0 2.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24221.1 - 1.3e-09 38.3 0.0 2.9e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA24221.1 - 0.042 13.0 0.0 0.068 12.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EEA24221.1 - 0.082 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Pkinase PF00069.25 EEA24222.1 - 4.4e-70 236.1 0.0 5.8e-70 235.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24222.1 - 4.8e-33 114.5 0.0 8.3e-33 113.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA24222.1 - 0.00062 19.2 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA24222.1 - 0.013 14.9 0.2 0.027 13.8 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA24222.1 - 0.047 12.5 0.0 0.047 12.5 0.0 2.1 3 0 0 3 3 3 0 Fungal protein kinase XRN_M PF17846.1 EEA24223.1 - 1.7e-100 337.1 3.1 2.9e-100 336.3 3.1 1.3 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EEA24223.1 - 4.8e-96 320.9 1.3 6.3e-96 320.5 0.0 1.8 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EEA24223.1 - 6.1e-76 254.5 0.5 1.6e-75 253.1 0.0 1.9 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EEA24223.1 - 9.9e-33 112.2 0.1 3.4e-32 110.5 0.1 2.0 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EEA24223.1 - 3.7e-24 84.6 0.3 8.3e-24 83.5 0.3 1.7 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 EEA24223.1 - 1.7e-07 31.2 1.4 4.6e-07 29.8 1.4 1.8 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 CAF1C_H4-bd PF12265.8 EEA24224.1 - 6.3e-28 96.8 2.8 9.9e-28 96.2 1.0 2.2 2 1 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EEA24224.1 - 2.1e-25 88.5 5.8 0.0001 23.0 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24224.1 - 1.6e-07 31.5 0.5 0.016 15.5 0.0 4.6 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EEA24224.1 - 0.0018 16.7 0.0 0.24 9.7 0.0 2.1 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz SGL PF08450.12 EEA24224.1 - 0.022 14.3 0.0 0.042 13.4 0.0 1.5 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region DUF3751 PF12571.8 EEA24224.1 - 0.038 14.1 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Phage tail-collar fibre protein GTP_cyclohydroI PF01227.22 EEA24225.1 - 1.7e-72 242.6 0.2 2.5e-72 242.1 0.2 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EEA24225.1 - 0.0028 17.8 0.0 0.0051 16.9 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein DUF3638 PF12340.8 EEA24225.1 - 0.089 12.1 0.3 0.14 11.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) GGACT PF06094.12 EEA24227.1 - 9.2e-19 68.2 0.0 1.6e-18 67.4 0.0 1.4 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Peptidase_C48 PF02902.19 EEA24228.1 - 2.4e-35 122.3 0.0 4.6e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain IF4E PF01652.18 EEA24229.1 - 9.6e-55 184.7 0.0 1.7e-54 183.9 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E HDA2-3 PF11496.8 EEA24231.1 - 1.2e-39 136.2 5.4 4.4e-39 134.4 0.0 3.2 2 2 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 GAS PF13851.6 EEA24231.1 - 0.014 14.8 43.5 0.062 12.7 29.2 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Baculo_PEP_C PF04513.12 EEA24231.1 - 0.02 14.9 0.6 0.02 14.9 0.6 3.8 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 EEA24231.1 - 0.11 12.5 45.9 1.5 8.8 9.2 4.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EEA24231.1 - 0.24 11.6 53.8 0.052 13.8 13.5 3.7 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Filament PF00038.21 EEA24231.1 - 4 6.9 45.2 0.26 10.8 32.9 2.6 1 1 1 2 2 2 0 Intermediate filament protein DUF3584 PF12128.8 EEA24231.1 - 5.1 4.5 39.0 8.8 3.7 39.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Pmp3 PF01679.17 EEA24232.1 - 2.8e-21 75.5 9.5 3.6e-21 75.1 9.5 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator SPC22 PF04573.12 EEA24233.1 - 3e-40 137.5 0.0 2.5e-37 128.0 0.0 2.2 1 1 0 1 1 1 1 Signal peptidase subunit BCDHK_Adom3 PF10436.9 EEA24234.1 - 3.7e-47 160.2 0.1 7.1e-47 159.3 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EEA24234.1 - 7e-05 23.3 0.0 0.00044 20.7 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EEA24234.1 - 0.12 12.3 0.0 1.4 8.8 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 EEA24234.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase USP7_ICP0_bdg PF12436.8 EEA24235.1 - 8.5e-88 293.7 0.2 1.8e-86 289.3 0.1 2.3 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EEA24235.1 - 5e-76 255.0 6.0 4.7e-74 248.5 1.1 3.3 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 EEA24235.1 - 2.2e-49 168.3 0.4 4e-49 167.4 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA24235.1 - 2.8e-19 69.9 0.0 1.1e-18 68.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EEA24235.1 - 4.5e-09 36.5 0.0 1.4e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 MATH domain Rad60-SLD PF11976.8 EEA24235.1 - 1.3e-05 24.9 2.8 0.99 9.3 0.0 4.5 4 1 0 4 4 4 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EEA24235.1 - 0.0078 16.0 1.9 34 4.3 0.0 5.1 5 0 0 5 5 5 0 Ubiquitin family YukD PF08817.10 EEA24235.1 - 0.043 14.5 0.0 9.4 7.0 0.0 2.9 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD YceG PF02618.16 EEA24235.1 - 0.073 12.6 1.2 9.3 5.7 0.0 3.3 3 1 0 4 4 4 0 YceG-like family FAD_binding_3 PF01494.19 EEA24236.1 - 1.3e-27 96.9 0.0 2.4e-15 56.6 0.0 2.0 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EEA24236.1 - 4.9e-10 39.5 4.3 1.4e-05 24.9 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA24236.1 - 1.8e-08 34.0 0.0 0.0003 20.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA24236.1 - 1.3e-06 28.8 0.0 0.006 17.1 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA24236.1 - 1.7e-06 27.4 1.3 5.7e-06 25.7 1.0 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EEA24236.1 - 0.0002 20.2 0.5 0.0087 14.8 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EEA24236.1 - 0.00043 20.5 1.0 0.0011 19.2 0.5 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EEA24236.1 - 0.00054 19.4 0.1 0.026 13.8 0.0 2.3 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EEA24236.1 - 0.0018 17.6 0.0 0.0038 16.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA24236.1 - 0.012 14.7 0.3 0.017 14.2 0.3 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EEA24236.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EEA24236.1 - 0.05 12.9 0.4 0.098 12.0 0.4 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EEA24236.1 - 0.052 12.6 0.6 6.1 5.8 0.4 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Ank_4 PF13637.6 EEA24237.1 - 0.002 18.6 0.0 0.19 12.3 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA24237.1 - 0.006 17.2 0.0 0.025 15.1 0.0 2.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA24237.1 - 0.018 15.5 0.2 0.3 11.6 0.1 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 EEA24237.1 - 0.027 15.0 0.0 0.63 10.8 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 EEA24237.1 - 0.08 13.3 0.3 0.43 11.0 0.1 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) MFS_1 PF07690.16 EEA24238.1 - 5.2e-23 81.5 44.5 5.2e-23 81.5 44.5 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA24238.1 - 1.2e-10 40.9 7.0 1.2e-10 40.9 7.0 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter EMP24_GP25L PF01105.24 EEA24239.1 - 1.4e-46 158.8 4.0 1.5e-46 158.6 4.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Spc7 PF08317.11 EEA24239.1 - 0.025 13.5 0.0 0.031 13.2 0.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein IrmA PF18673.1 EEA24239.1 - 0.089 12.9 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 interleukin receptor mimic protein A DUF2012 PF09430.10 EEA24239.1 - 0.098 12.8 0.2 0.19 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Glyco_hydro_3_C PF01915.22 EEA24241.1 - 7.1e-56 189.4 0.0 1.6e-55 188.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA24241.1 - 9.3e-47 159.9 0.0 1.4e-46 159.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA24241.1 - 5.2e-21 74.5 0.1 1.8e-20 72.8 0.1 1.9 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EEA24241.1 - 9.5e-17 61.2 0.0 2.2e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 PA14 domain Phage_tail_X PF05489.12 EEA24241.1 - 0.044 13.5 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Phage Tail Protein X Hydrophobin PF01185.18 EEA24242.1 - 3.4e-10 40.4 7.6 3.7e-09 37.1 2.4 2.8 2 1 1 3 3 3 2 Fungal hydrophobin RNA_pol_Rpc4 PF05132.14 EEA24242.1 - 0.0022 18.4 4.0 0.11 12.9 3.6 2.3 2 0 0 2 2 2 1 RNA polymerase III RPC4 Corona_nucleoca PF00937.18 EEA24242.1 - 0.46 9.5 6.8 0.14 11.2 2.1 1.9 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein Miga PF10265.9 EEA24242.1 - 1.4 7.8 10.7 1.9 7.3 10.7 1.1 1 0 0 1 1 1 0 Mitoguardin CTD_bind PF04818.13 EEA24243.1 - 5.7e-12 46.3 0.3 1.7e-11 44.7 0.1 2.0 3 0 0 3 3 3 1 RNA polymerase II-binding domain. Pkinase PF00069.25 EEA24244.1 - 1.3e-09 37.8 0.0 2e-09 37.2 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain DUF4748 PF15932.5 EEA24245.1 - 2.6e-24 84.7 2.2 4.6e-24 83.9 2.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) ERCC3_RAD25_C PF16203.5 EEA24246.1 - 1.6e-124 414.0 0.4 4e-124 412.7 0.4 1.7 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EEA24246.1 - 5.7e-35 120.2 0.0 2e-34 118.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA24246.1 - 8.8e-16 58.4 0.0 1.9e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA24246.1 - 4.8e-13 49.4 0.2 1.1e-12 48.2 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EEA24246.1 - 3e-08 32.8 0.0 3.7e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 EEA24246.1 - 0.00074 19.3 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.6 EEA24246.1 - 0.0015 17.5 0.0 0.0027 16.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF4677 PF15726.5 EEA24246.1 - 0.023 14.8 0.4 0.1 12.8 0.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) AChE_tetra PF08674.10 EEA24246.1 - 5.8 6.7 5.5 1.8 8.3 0.9 2.5 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain Aldo_ket_red PF00248.21 EEA24247.1 - 2.2e-37 128.9 0.0 4.4e-36 124.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family PSK_trans_fac PF07704.11 EEA24247.1 - 0.072 13.9 0.1 0.56 11.0 0.0 2.2 2 0 0 2 2 2 0 Rv0623-like transcription factor Sugar_tr PF00083.24 EEA24248.1 - 2e-07 30.3 2.0 2.6e-07 29.9 2.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24248.1 - 3.6e-06 26.2 7.6 4.8e-06 25.7 7.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 EEA24249.1 - 4.1e-09 36.4 10.0 4.1e-09 36.4 10.0 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA24249.1 - 0.069 12.2 0.1 0.12 11.4 0.1 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Rep_fac-A_C PF08646.10 EEA24249.1 - 0.2 11.4 1.7 0.34 10.7 1.7 1.3 1 0 0 1 1 1 0 Replication factor-A C terminal domain Phosphodiest PF01663.22 EEA24251.1 - 2.2e-17 63.7 0.0 4.6e-17 62.7 0.0 1.5 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase HD PF01966.22 EEA24251.1 - 0.00011 22.4 0.1 0.00022 21.4 0.1 1.5 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 EEA24251.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 HDOD domain PhyH PF05721.13 EEA24252.1 - 2.7e-27 96.4 0.0 3.4e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EEA24252.1 - 0.00071 19.9 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Cupin_2 PF07883.11 EEA24252.1 - 0.081 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Questin_oxidase PF14027.6 EEA24253.1 - 1.3e-94 317.6 0.5 1.6e-94 317.2 0.5 1.1 1 0 0 1 1 1 1 Questin oxidase-like DUF1910 PF08928.10 EEA24253.1 - 0.0071 16.3 1.5 0.37 10.8 0.0 2.6 3 0 0 3 3 3 2 Domain of unknown function (DUF1910) RVT_1 PF00078.27 EEA24254.1 - 5.9e-28 97.9 0.0 1.4e-26 93.4 0.0 2.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA24254.1 - 1.7e-21 76.3 0.0 4.2e-21 75.0 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EEA24254.1 - 0.00015 21.3 0.0 0.00027 20.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EEA24254.1 - 0.0076 16.3 0.8 0.015 15.3 0.8 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF16 PF01519.16 EEA24254.1 - 0.11 12.9 6.1 0.036 14.6 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF16 RNA_pol_L_2 PF13656.6 EEA24254.1 - 0.13 12.1 0.5 0.8 9.5 0.0 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Dynactin_p22 PF07426.11 EEA24254.1 - 0.19 11.6 4.1 0.23 11.3 2.2 2.1 2 0 0 2 2 2 0 Dynactin subunit p22 Fib_alpha PF08702.10 EEA24254.1 - 6 7.0 11.6 0.23 11.6 3.7 2.6 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family MPM1 PF17234.2 EEA24255.1 - 0.011 16.0 0.9 0.026 14.8 0.9 1.6 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Glyco_hydro_18 PF00704.28 EEA24256.1 - 3.6e-20 72.9 5.5 2.9e-19 70.0 5.5 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 E1-E2_ATPase PF00122.20 EEA24257.1 - 1.4e-34 119.2 4.7 1.2e-21 77.1 0.1 3.6 3 0 0 3 3 3 3 E1-E2 ATPase Hydrolase PF00702.26 EEA24257.1 - 3.6e-18 66.6 0.0 8.1e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA24257.1 - 1e-09 37.9 0.0 2.1e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EEA24257.1 - 0.0071 16.1 0.2 0.026 14.3 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA24257.1 - 0.008 16.2 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) CDC45 PF02724.14 EEA24257.1 - 0.021 13.2 2.7 0.038 12.3 2.7 1.4 1 0 0 1 1 1 0 CDC45-like protein B12-binding PF02310.19 EEA24257.1 - 0.028 14.5 0.3 0.11 12.5 0.0 2.2 2 0 0 2 2 2 0 B12 binding domain FixP_N PF14715.6 EEA24257.1 - 1.7 8.5 5.7 13 5.7 0.5 2.8 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Nop14 PF04147.12 EEA24257.1 - 2.5 6.2 8.3 3.5 5.7 8.3 1.1 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 EEA24257.1 - 5.8 5.8 12.9 10 5.0 12.9 1.3 1 0 0 1 1 1 0 Paf1 Arylesterase PF01731.20 EEA24258.1 - 0.0004 20.5 0.0 0.001 19.2 0.0 1.7 2 0 0 2 2 2 1 Arylesterase SGL PF08450.12 EEA24258.1 - 0.0019 17.8 0.0 0.032 13.8 0.0 2.1 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Tetraspanin PF00335.20 EEA24259.1 - 1.9e-07 31.0 2.5 7.4e-07 29.1 2.5 1.8 1 1 0 1 1 1 1 Tetraspanin family tRNA-synt_1c PF00749.21 EEA24261.1 - 1.6e-102 342.6 0.0 2.1e-102 342.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EEA24261.1 - 7.8e-38 130.1 0.3 1.8e-37 128.9 0.2 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.6 EEA24261.1 - 0.0058 16.8 0.1 0.18 12.0 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA24261.1 - 0.014 15.6 0.1 0.036 14.3 0.1 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA24261.1 - 0.066 13.3 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ribosomal_L1 PF00687.21 EEA24262.1 - 1.7e-28 99.7 0.0 2.3e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Ribosomal_L1 PF00687.21 EEA24263.1 - 8.3e-27 94.2 0.0 1.2e-26 93.8 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family COG2 PF06148.11 EEA24264.1 - 5.5e-35 120.3 0.4 1.3e-34 119.1 0.4 1.7 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EEA24264.1 - 4e-05 23.6 1.7 0.00024 21.1 0.0 2.7 2 1 0 2 2 2 1 Vps51/Vps67 Sec8_exocyst PF04048.14 EEA24264.1 - 0.0099 15.8 0.3 0.024 14.5 0.3 1.7 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Baculo_PEP_C PF04513.12 EEA24264.1 - 0.071 13.1 0.7 1.8 8.6 0.0 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SKA2 PF16740.5 EEA24264.1 - 0.077 12.8 3.6 1.9 8.3 0.3 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 FUSC PF04632.12 EEA24264.1 - 0.11 11.0 0.1 0.23 9.9 0.0 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family Bcr-Abl_Oligo PF09036.10 EEA24264.1 - 0.16 12.0 1.6 0.39 10.7 0.0 2.4 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain DUF2120 PF09893.9 EEA24264.1 - 0.42 10.7 5.5 0.49 10.5 0.2 2.2 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) DUF4665 PF15679.5 EEA24264.1 - 2.1 9.0 4.3 33 5.2 0.1 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4665) DUF749 PF05370.11 EEA24264.1 - 7.9 6.6 8.2 7.1 6.8 1.3 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF749) ParA PF10609.9 EEA24266.1 - 6.1e-86 287.9 0.1 1.8e-85 286.3 0.1 1.6 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EEA24266.1 - 1.7e-09 37.8 0.0 6.4e-09 35.9 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EEA24266.1 - 1.6e-06 27.7 0.0 7.3e-06 25.5 0.0 1.8 1 1 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 EEA24266.1 - 3.1e-05 24.0 0.4 0.0001 22.3 0.4 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EEA24266.1 - 0.00053 19.3 0.3 0.0012 18.1 0.3 1.5 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_25 PF13481.6 EEA24266.1 - 0.00055 19.6 0.1 0.00088 18.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 EEA24266.1 - 0.0035 16.9 0.0 0.0086 15.6 0.0 1.7 2 1 0 2 2 2 1 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 EEA24266.1 - 0.01 14.9 0.5 0.016 14.2 0.5 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_26 PF13500.6 EEA24266.1 - 0.011 15.6 0.9 4.5 7.0 0.7 2.7 3 0 0 3 3 3 0 AAA domain APS_kinase PF01583.20 EEA24266.1 - 0.059 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Fer4_NifH PF00142.18 EEA24266.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family RsgA_GTPase PF03193.16 EEA24266.1 - 2.8 7.8 4.1 1.2 9.0 1.4 1.7 2 0 0 2 2 2 0 RsgA GTPase TOM13 PF08219.11 EEA24267.1 - 3e-35 120.0 0.0 3.9e-35 119.7 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 SEP PF08059.13 EEA24268.1 - 4e-25 88.2 0.0 9.9e-25 86.9 0.0 1.7 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.6 EEA24268.1 - 5.1e-15 55.0 0.3 9.1e-15 54.2 0.3 1.4 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EEA24268.1 - 6.4e-14 51.9 0.0 1.1e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 UBX domain TAP_C PF03943.13 EEA24268.1 - 0.00017 21.2 0.0 0.00027 20.5 0.0 1.3 1 0 0 1 1 1 1 TAP C-terminal domain 60KD_IMP PF02096.20 EEA24269.1 - 2.1e-23 83.0 0.1 4.1e-23 82.1 0.1 1.5 1 0 0 1 1 1 1 60Kd inner membrane protein PEP-utilisers_N PF05524.13 EEA24269.1 - 2.7 8.2 8.8 1.1 9.4 5.6 2.0 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal Fungal_trans PF04082.18 EEA24270.1 - 2.5e-17 62.8 0.3 4.5e-17 62.0 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24270.1 - 5.1e-07 29.7 11.5 9.6e-07 28.8 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TAFII28 PF04719.14 EEA24273.1 - 2.5e-25 88.4 2.2 8.2e-24 83.5 0.6 2.3 2 0 0 2 2 2 1 hTAFII28-like protein conserved region SIMPL PF04402.14 EEA24273.1 - 0.00097 19.6 3.1 0.0015 19.0 3.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Methyltrans_RNA PF04452.14 EEA24273.1 - 0.018 14.4 0.7 0.038 13.3 0.6 1.6 1 1 0 1 1 1 0 RNA methyltransferase BSP_II PF05432.11 EEA24273.1 - 0.12 12.0 11.8 0.75 9.4 1.3 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TAF6_C PF07571.13 EEA24274.1 - 2.9e-31 107.6 0.0 7.5e-31 106.3 0.0 1.8 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EEA24274.1 - 7.5e-26 90.1 0.0 1.9e-25 88.8 0.1 1.7 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EEA24274.1 - 0.0024 18.3 0.2 0.0058 17.0 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA24274.1 - 0.0038 17.5 0.1 0.012 15.9 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EEA24274.1 - 0.0088 16.1 0.1 0.028 14.5 0.1 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EEA24274.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Bromodomain associated SAM_decarbox PF01536.16 EEA24275.1 - 4.7e-132 440.3 0.0 5.6e-132 440.1 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase CRAL_TRIO PF00650.20 EEA24276.1 - 2.7e-15 56.5 0.0 3.7e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA24276.1 - 4.1e-09 36.5 0.0 9e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain PI-PLC-C1 PF16670.5 EEA24277.1 - 4.5e-125 417.1 0.0 5.3e-125 416.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoinositide phospholipase C, Ca2+-dependent Involucrin2 PF06994.11 EEA24277.1 - 1.4 9.1 6.6 2.7 8.1 6.6 1.4 1 0 0 1 1 1 0 Involucrin IPP-2 PF04979.14 EEA24278.1 - 6.7e-20 72.2 24.4 1e-18 68.4 21.2 2.5 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) IPP-2 PF04979.14 EEA24279.1 - 6.7e-20 72.2 24.4 1e-18 68.4 21.2 2.5 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) GMC_oxred_N PF00732.19 EEA24280.1 - 1.4e-59 201.9 0.0 1.8e-59 201.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA24280.1 - 4e-35 121.4 0.0 6.4e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EEA24280.1 - 5.3e-07 29.0 0.0 9.1e-07 28.2 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EEA24280.1 - 2.7e-05 24.3 0.4 0.00016 21.8 0.0 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA24280.1 - 0.00047 19.3 0.4 0.04 13.0 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA24280.1 - 0.00088 18.6 0.1 0.0031 16.8 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA24280.1 - 0.0023 17.6 4.5 0.0075 15.9 4.6 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA24280.1 - 0.015 14.5 0.1 0.033 13.4 0.1 1.5 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EEA24280.1 - 0.025 13.4 0.2 0.036 12.9 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_9 PF13454.6 EEA24280.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EEA24280.1 - 0.1 11.3 0.1 0.2 10.3 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 EEA24280.1 - 0.13 11.5 0.0 1.4 8.2 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA24280.1 - 0.17 10.9 0.1 0.87 8.6 0.0 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF3682 PF12446.8 EEA24281.1 - 1.3 9.5 12.1 0.18 12.3 6.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) CAF1A PF12253.8 EEA24282.1 - 5.5e-22 77.7 3.8 5.5e-22 77.7 3.8 3.8 2 1 0 2 2 1 1 Chromatin assembly factor 1 subunit A Peptidase_S64 PF08192.11 EEA24282.1 - 0.066 11.7 16.1 0.093 11.2 16.1 1.2 1 0 0 1 1 1 0 Peptidase family S64 CAF-1_p150 PF11600.8 EEA24282.1 - 0.073 12.8 62.0 0.17 11.5 62.0 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Cwf_Cwc_15 PF04889.12 EEA24282.1 - 0.099 12.4 36.1 0.73 9.5 26.4 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Asp-B-Hydro_N PF05279.11 EEA24282.1 - 0.22 11.6 29.4 0.61 10.1 29.4 1.8 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF262 PF03235.14 EEA24282.1 - 0.28 11.3 7.0 0.52 10.4 7.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF262 Mitofilin PF09731.9 EEA24282.1 - 0.98 8.2 35.6 1.6 7.5 35.6 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Hamartin PF04388.12 EEA24282.1 - 0.99 8.0 26.3 1.4 7.5 26.3 1.3 1 0 0 1 1 1 0 Hamartin protein Raftlin PF15250.6 EEA24282.1 - 1.8 7.3 20.2 3.5 6.3 20.2 1.4 1 0 0 1 1 1 0 Raftlin FAM60A PF15396.6 EEA24282.1 - 2.8 7.9 25.4 9 6.2 25.4 1.9 1 0 0 1 1 1 0 Protein Family FAM60A Zip PF02535.22 EEA24282.1 - 5.9 6.0 12.5 12 4.9 12.5 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter CoA_transf_3 PF02515.17 EEA24284.1 - 6e-65 219.7 0.0 8.2e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III WW PF00397.26 EEA24285.1 - 5.4e-10 39.2 0.5 1.3e-09 38.0 0.5 1.7 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 EEA24285.1 - 3.3e-05 24.1 0.2 3.7e-05 23.9 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Remorin_C PF03763.13 EEA24285.1 - 0.065 13.1 0.1 0.065 13.1 0.1 1.5 2 0 0 2 2 2 0 Remorin, C-terminal region RVT_2 PF07727.14 EEA24286.1 - 5.7e-34 117.8 0.1 1.1e-33 116.9 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA24286.1 - 1.6e-08 34.8 0.0 6e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EEA24286.1 - 2e-06 27.6 0.0 4.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain Ank_2 PF12796.7 EEA24287.1 - 2.8e-44 149.6 0.3 3.4e-15 56.4 0.3 6.1 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA24287.1 - 6.3e-42 141.4 0.5 1.2e-09 38.5 0.0 8.6 3 1 5 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA24287.1 - 6.5e-35 115.2 0.5 6.7e-05 23.0 0.0 10.8 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 EEA24287.1 - 4.1e-31 106.0 1.1 3.9e-07 30.2 0.0 8.4 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EEA24287.1 - 8.6e-28 96.0 9.1 7.1e-10 38.9 0.0 7.6 3 1 6 9 9 9 6 Ankyrin repeats (many copies) CorA PF01544.18 EEA24287.1 - 4.1e-09 36.2 0.3 4.1e-09 36.2 0.3 2.2 3 0 0 3 3 3 1 CorA-like Mg2+ transporter protein SLAC1 PF03595.17 EEA24287.1 - 0.15 11.3 4.8 0.25 10.6 4.8 1.2 1 0 0 1 1 1 0 Voltage-dependent anion channel Fungal_trans PF04082.18 EEA24288.1 - 5.9e-15 55.0 1.0 5.9e-15 55.0 1.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain adh_short PF00106.25 EEA24289.1 - 2.8e-24 85.6 0.0 2.1e-17 63.2 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24289.1 - 1.2e-12 47.9 0.0 6.7e-07 29.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24289.1 - 4.9e-06 26.6 0.1 7.7e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA24289.1 - 0.0062 15.7 0.0 0.13 11.4 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Aldo_ket_red PF00248.21 EEA24290.1 - 4.5e-36 124.6 0.0 6.6e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_18 PF00704.28 EEA24292.1 - 1.9e-19 70.5 0.2 6.2e-19 68.9 0.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Spc7 PF08317.11 EEA24294.1 - 2.1e-06 26.8 70.6 9e-05 21.5 19.1 4.2 4 0 0 4 4 4 4 Spc7 kinetochore protein Fez1 PF06818.15 EEA24294.1 - 2.7e-05 24.7 69.1 0.026 15.0 18.6 5.1 1 1 4 5 5 5 3 Fez1 DUF4200 PF13863.6 EEA24294.1 - 0.0057 17.0 14.2 0.0057 17.0 14.2 5.7 4 2 1 5 5 5 2 Domain of unknown function (DUF4200) HALZ PF02183.18 EEA24294.1 - 0.079 13.2 0.3 0.079 13.2 0.3 5.5 5 1 0 5 5 5 0 Homeobox associated leucine zipper Filament PF00038.21 EEA24294.1 - 0.21 11.1 75.2 0.62 9.6 18.8 4.1 1 1 2 3 3 3 0 Intermediate filament protein BRX_N PF13713.6 EEA24294.1 - 0.42 10.4 3.2 0.63 9.9 0.0 2.6 2 0 0 2 2 2 0 Transcription factor BRX N-terminal domain ATG16 PF08614.11 EEA24294.1 - 1 9.6 83.6 0.14 12.4 6.0 6.1 2 1 5 7 7 7 0 Autophagy protein 16 (ATG16) FliJ PF02050.16 EEA24294.1 - 1.2 9.3 57.0 0.1 12.9 10.3 4.9 4 2 0 4 4 4 0 Flagellar FliJ protein TSC22 PF01166.18 EEA24294.1 - 1.4 9.3 28.4 0.47 10.8 1.1 7.0 4 1 2 6 6 6 0 TSC-22/dip/bun family AAA_13 PF13166.6 EEA24294.1 - 5.1 5.6 55.2 2.1 6.9 23.2 3.4 1 1 0 2 2 2 0 AAA domain Glyco_hydro_18 PF00704.28 EEA24295.1 - 3.6e-14 53.2 0.0 4.9e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Zn_clus PF00172.18 EEA24296.1 - 1.4e-06 28.4 11.6 2.8e-06 27.3 11.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA24296.1 - 0.00013 20.9 0.8 0.00033 19.6 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain FAD_binding_3 PF01494.19 EEA24297.1 - 4.1e-25 88.8 0.1 2e-24 86.5 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA24297.1 - 6.4e-07 29.5 0.1 1.7e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA24297.1 - 5.8e-06 25.8 0.3 0.0011 18.3 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA24297.1 - 2.4e-05 24.1 1.4 0.00011 21.9 0.4 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA24297.1 - 2.9e-05 24.6 0.2 0.0011 19.5 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA24297.1 - 0.00065 19.1 0.3 0.0027 17.0 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA24297.1 - 0.0011 18.4 0.1 0.53 9.5 0.0 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EEA24297.1 - 0.0027 16.9 0.5 0.0055 15.8 0.3 1.5 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EEA24297.1 - 0.0048 16.0 1.3 0.054 12.5 1.2 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.14 EEA24297.1 - 0.006 15.5 0.0 0.0095 14.8 0.0 1.3 1 0 0 1 1 1 1 Tryptophan halogenase Thi4 PF01946.17 EEA24297.1 - 0.0097 15.2 0.1 0.018 14.3 0.1 1.4 1 0 0 1 1 1 1 Thi4 family UDPG_MGDP_dh_N PF03721.14 EEA24297.1 - 0.043 13.4 0.2 0.089 12.4 0.2 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EEA24297.1 - 0.043 14.3 0.0 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.18 EEA24297.1 - 0.073 13.3 0.1 0.2 11.9 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain GIDA PF01134.22 EEA24297.1 - 0.087 11.9 0.2 0.14 11.2 0.2 1.4 1 1 0 1 1 1 0 Glucose inhibited division protein A KGG PF10685.9 EEA24298.1 - 4.2e-17 61.8 15.3 7.9e-09 35.5 0.4 3.6 3 1 1 4 4 4 3 Stress-induced bacterial acidophilic repeat motif DUF5551 PF17705.1 EEA24298.1 - 0.015 14.9 1.3 0.034 13.8 0.1 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5551) AT_hook PF02178.19 EEA24298.1 - 7.3 6.8 11.2 1.1 9.4 0.3 3.2 2 0 0 2 2 2 0 AT hook motif PhoD PF09423.10 EEA24299.1 - 2.4e-36 125.5 0.0 6.6e-36 124.0 0.0 1.7 1 1 0 1 1 1 1 PhoD-like phosphatase Pur_ac_phosph_N PF16656.5 EEA24299.1 - 0.00047 20.7 0.3 0.0013 19.2 0.3 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 EEA24299.1 - 0.0081 16.7 0.1 0.023 15.2 0.1 1.7 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain SRP54 PF00448.22 EEA24300.1 - 1.9e-74 249.6 2.8 1.9e-74 249.6 2.8 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EEA24300.1 - 1.8e-28 99.0 0.2 1.8e-28 99.0 0.2 4.4 4 1 2 6 6 3 1 Signal peptide binding domain SRP54_N PF02881.19 EEA24300.1 - 1.8e-20 73.0 2.4 1.9e-20 72.9 0.7 2.0 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EEA24300.1 - 7.1e-07 29.0 0.3 2e-06 27.5 0.3 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EEA24300.1 - 1.9e-05 25.1 0.1 1.9e-05 25.1 0.1 2.0 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 EEA24300.1 - 5.8e-05 23.3 0.0 0.00015 22.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA24300.1 - 6.9e-05 23.3 0.0 0.00015 22.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 EEA24300.1 - 0.00025 20.1 1.6 0.0023 17.0 0.2 2.9 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EEA24300.1 - 0.0014 19.0 0.1 0.014 15.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EEA24300.1 - 0.002 18.2 0.0 0.0055 16.8 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 EEA24300.1 - 0.0022 18.1 0.2 0.02 15.0 0.1 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EEA24300.1 - 0.0022 17.3 0.1 0.0022 17.3 0.1 1.8 2 0 0 2 2 1 1 Zeta toxin AAA_30 PF13604.6 EEA24300.1 - 0.0026 17.5 0.2 0.0078 15.9 0.2 1.9 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 EEA24300.1 - 0.0035 17.2 0.0 0.0092 15.9 0.0 1.7 1 0 0 1 1 1 1 Adenylylsulphate kinase SRPRB PF09439.10 EEA24300.1 - 0.0061 16.0 0.8 1.7 8.0 0.9 2.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 EEA24300.1 - 0.0064 17.0 0.1 0.016 15.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EEA24300.1 - 0.0093 16.2 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EEA24300.1 - 0.012 15.4 0.4 0.036 13.8 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein 6PF2K PF01591.18 EEA24300.1 - 0.016 14.5 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MobB PF03205.14 EEA24300.1 - 0.017 15.0 0.1 0.053 13.4 0.0 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B Thymidylate_kin PF02223.17 EEA24300.1 - 0.021 14.5 0.2 0.062 13.0 0.1 1.9 2 0 0 2 2 1 0 Thymidylate kinase ResIII PF04851.15 EEA24300.1 - 0.039 14.0 1.0 0.27 11.2 1.0 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit HAUS2 PF15003.6 EEA24300.1 - 0.042 13.6 1.0 0.06 13.1 0.1 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 AAA_31 PF13614.6 EEA24300.1 - 0.042 13.8 0.3 0.31 10.9 0.1 2.2 1 1 1 2 2 2 0 AAA domain Methyltransf_25 PF13649.6 EEA24300.1 - 0.083 13.6 0.4 6.4 7.5 0.0 3.0 3 0 0 3 3 2 0 Methyltransferase domain AAA_24 PF13479.6 EEA24300.1 - 0.091 12.5 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Methyltransf_24 PF13578.6 EEA24300.1 - 0.15 13.1 0.0 0.36 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Rrp15p PF07890.12 EEA24301.1 - 7.3e-38 129.9 13.1 7.3e-38 129.9 13.1 2.4 2 1 0 2 2 2 1 Rrp15p Dioxygenase_N PF04444.14 EEA24301.1 - 0.11 12.4 0.2 4.5 7.2 0.1 2.4 2 0 0 2 2 2 0 Catechol dioxygenase N terminus DUF3295 PF11702.8 EEA24301.1 - 0.3 10.4 19.1 0.39 10.0 19.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) FAM75 PF14650.6 EEA24301.1 - 0.38 10.2 8.6 0.093 12.3 4.2 1.9 2 0 0 2 2 2 0 FAM75 family Fer2 PF00111.27 EEA24302.1 - 1.1e-13 51.0 0.5 1.5e-13 50.5 0.5 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain YcgR_2 PF12945.7 EEA24302.1 - 0.078 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Flagellar protein YcgR Mito_carr PF00153.27 EEA24303.1 - 2.1e-10 40.4 5.8 0.0017 18.2 0.0 5.0 4 2 0 4 4 4 4 Mitochondrial carrier protein MAP65_ASE1 PF03999.12 EEA24303.1 - 0.0096 14.7 1.0 0.014 14.1 1.0 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) NMO PF03060.15 EEA24304.1 - 7e-55 186.7 1.1 6.4e-54 183.6 1.1 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EEA24304.1 - 7.8e-10 38.3 0.0 1.7e-08 33.9 0.0 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EEA24304.1 - 0.0022 17.1 0.1 0.0036 16.4 0.1 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.14 EEA24304.1 - 0.012 14.9 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 EEA24304.1 - 0.024 14.1 0.1 0.047 13.2 0.1 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Glu_synthase PF01645.17 EEA24304.1 - 0.042 13.0 0.0 0.099 11.8 0.0 1.6 2 0 0 2 2 2 0 Conserved region in glutamate synthase TMP-TENI PF02581.17 EEA24304.1 - 0.062 12.6 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 Thiamine monophosphate synthase Hydrophobin PF01185.18 EEA24305.1 - 2.3e-08 34.5 7.0 3.4e-08 34.0 7.0 1.3 1 0 0 1 1 1 1 Fungal hydrophobin FAD_binding_2 PF00890.24 EEA24306.1 - 1.9e-119 399.4 1.5 2.6e-119 399.0 1.5 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EEA24306.1 - 1.7e-41 141.2 1.5 2.5e-41 140.6 1.5 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EEA24306.1 - 5.7e-06 25.8 1.1 0.0033 16.7 0.4 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA24306.1 - 0.00035 19.8 1.9 0.042 12.9 2.5 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EEA24306.1 - 0.0028 16.9 0.2 0.7 9.1 0.0 2.6 3 0 0 3 3 3 2 Thi4 family FAD_binding_3 PF01494.19 EEA24306.1 - 0.016 14.4 0.8 0.033 13.4 0.8 1.4 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 EEA24306.1 - 0.054 13.1 0.3 0.11 12.1 0.3 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase WW PF00397.26 EEA24307.1 - 3.8e-10 39.7 1.1 1e-09 38.3 1.1 1.8 1 0 0 1 1 1 1 WW domain SDA1 PF05285.12 EEA24307.1 - 0.0026 17.3 17.2 0.0049 16.4 17.2 1.3 1 1 0 1 1 1 1 SDA1 WRW PF10206.9 EEA24307.1 - 0.038 14.4 0.9 0.19 12.1 0.9 2.0 1 1 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f Ank_4 PF13637.6 EEA24308.1 - 4.9e-14 52.5 0.3 9.7e-08 32.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA24308.1 - 1e-12 48.4 0.2 3.3e-12 46.8 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA24308.1 - 4.9e-10 39.5 0.9 5.4e-08 33.0 0.4 3.2 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA24308.1 - 6.3e-10 38.4 0.3 2.7e-06 27.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EEA24308.1 - 1.4e-08 34.8 2.5 1.5e-06 28.4 0.2 2.9 3 0 0 3 3 3 2 Ankyrin repeat Glyco_transf_21 PF13506.6 EEA24309.1 - 1.3e-12 47.5 0.1 7.6e-06 25.5 0.0 3.9 3 1 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EEA24309.1 - 3.8e-07 30.2 0.0 9.1e-07 29.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EEA24309.1 - 0.00023 21.0 0.0 0.17 11.6 0.0 2.9 3 0 0 3 3 3 2 Glycosyl transferase family 2 HAT_KAT11 PF08214.11 EEA24310.1 - 7.4e-103 344.5 0.0 9.9e-103 344.1 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein Hid1 PF12722.7 EEA24311.1 - 0 1099.5 0.0 0 1099.4 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EEA24311.1 - 3e-99 333.2 0.0 3.4e-99 333.0 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein NPCC PF08058.11 EEA24312.1 - 3.1e-24 85.5 0.0 5.1e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore complex component AMP-binding PF00501.28 EEA24313.1 - 8.5e-07 27.9 0.1 0.00046 18.9 0.0 2.2 2 1 0 2 2 2 2 AMP-binding enzyme Ribosomal_L19 PF01245.20 EEA24315.1 - 8.2e-16 57.9 0.1 1.5e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L19 Hap4_Hap_bind PF10297.9 EEA24316.1 - 4.2e-09 36.2 6.9 1.2e-08 34.8 6.9 1.8 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 EEA24316.1 - 5.4e-07 29.6 7.0 8.3e-07 29.0 6.4 1.6 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EEA24316.1 - 0.00013 22.0 4.2 0.00029 20.9 4.2 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Striatin PF08232.12 EEA24316.1 - 0.00073 20.2 2.1 0.001 19.7 0.9 1.8 1 1 0 1 1 1 1 Striatin family dsrm PF00035.26 EEA24316.1 - 0.024 15.3 0.0 0.063 14.0 0.0 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding motif Fmp27_WPPW PF10359.9 EEA24316.1 - 0.083 11.7 3.4 0.11 11.4 3.4 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain LCD1 PF09798.9 EEA24316.1 - 0.084 11.4 1.6 0.11 11.0 1.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Baculo_PEP_C PF04513.12 EEA24316.1 - 0.094 12.8 0.2 0.18 11.9 0.2 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus FapA PF03961.13 EEA24316.1 - 0.1 11.2 1.8 0.14 10.7 1.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Plk4_PB2 PF18409.1 EEA24316.1 - 0.17 12.5 1.2 0.27 11.9 0.2 1.8 2 0 0 2 2 1 0 Polo-like Kinase 4 Polo Box 2 KxDL PF10241.9 EEA24316.1 - 0.2 12.0 2.0 0.41 10.9 2.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein DUF1640 PF07798.11 EEA24316.1 - 0.36 10.9 5.3 0.64 10.0 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4757 PF15949.5 EEA24316.1 - 0.46 10.9 9.0 0.37 11.3 5.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4757) SlyX PF04102.12 EEA24316.1 - 0.6 10.8 3.3 1.6 9.4 3.3 1.8 1 0 0 1 1 1 0 SlyX bZIP_Maf PF03131.17 EEA24316.1 - 3.9 8.0 11.0 0.39 11.3 5.8 1.9 1 1 1 2 2 2 0 bZIP Maf transcription factor Jnk-SapK_ap_N PF09744.9 EEA24316.1 - 4.3 7.5 8.6 6.9 6.9 8.6 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 EEA24316.1 - 5.3 6.3 7.6 8.1 5.7 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sdh_cyt PF01127.22 EEA24317.1 - 1.2e-24 86.7 4.4 1.7e-24 86.1 4.4 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Mg_trans_NIPA PF05653.14 EEA24317.1 - 0.0062 15.7 0.5 0.0075 15.4 0.5 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA NTP_transf_3 PF12804.7 EEA24318.1 - 6.5e-22 78.6 0.2 1.9e-12 47.8 0.0 2.1 1 1 1 2 2 2 2 MobA-like NTP transferase domain Adap_comp_sub PF00928.21 EEA24319.1 - 3.5e-91 305.2 0.0 5.1e-91 304.7 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family MoeA_N PF03453.17 EEA24319.1 - 1.3e-29 102.9 0.1 2.8e-29 101.9 0.1 1.6 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 EEA24319.1 - 2.1e-24 85.8 0.0 3.7e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain Clat_adaptor_s PF01217.20 EEA24319.1 - 5.9e-09 36.0 0.3 1e-08 35.2 0.3 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MoeA_C PF03454.15 EEA24319.1 - 1.1e-06 28.7 0.0 2.9e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Ribonucleas_3_3 PF14622.6 EEA24320.1 - 1.4e-24 86.7 0.0 2.9e-24 85.7 0.0 1.5 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EEA24320.1 - 0.0022 18.6 0.0 0.011 16.3 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease III domain Abhydrolase_6 PF12697.7 EEA24321.1 - 1.2e-16 62.0 1.3 1.4e-16 61.7 1.3 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA24321.1 - 0.0037 17.0 0.0 0.032 13.9 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA24321.1 - 0.036 13.3 0.1 0.8 8.9 0.0 2.6 3 1 0 3 3 3 0 Serine aminopeptidase, S33 Dyp_perox PF04261.12 EEA24322.1 - 4.9e-87 292.0 0.0 5.8e-87 291.7 0.0 1.0 1 0 0 1 1 1 1 Dyp-type peroxidase family Oxidored_molyb PF00174.19 EEA24323.1 - 6.6e-35 120.2 0.0 1.2e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EEA24323.1 - 2e-11 44.1 0.1 3.5e-11 43.3 0.1 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain WD40 PF00400.32 EEA24325.1 - 4.1e-18 65.4 6.9 4e-11 43.3 0.3 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24325.1 - 3.3e-07 30.5 0.0 0.015 15.6 0.0 4.7 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA24325.1 - 0.0012 17.6 0.1 0.085 11.5 0.0 2.5 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 EEA24325.1 - 0.0087 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region Nucleoporin_N PF08801.11 EEA24325.1 - 0.014 14.1 0.0 2.2 6.9 0.0 2.8 1 1 1 3 3 3 0 Nup133 N terminal like Nbas_N PF15492.6 EEA24325.1 - 0.021 14.1 0.0 1.3 8.3 0.0 3.1 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 EEA24325.1 - 0.03 13.6 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain Ge1_WD40 PF16529.5 EEA24325.1 - 0.15 11.0 0.0 0.25 10.2 0.0 1.5 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Amidase PF01425.21 EEA24326.1 - 0.00031 19.8 0.0 0.065 12.2 0.0 2.1 2 0 0 2 2 2 2 Amidase Molybdopterin PF00384.22 EEA24327.1 - 7e-70 236.1 0.0 1.3e-69 235.3 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 EEA24327.1 - 4.6e-28 97.5 0.0 1.1e-27 96.3 0.0 1.7 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 EEA24327.1 - 3.6e-13 49.3 0.9 8.6e-13 48.1 0.4 2.0 2 0 0 2 2 2 1 Molybdopterin oxidoreductase Fe4S4 domain Gtr1_RagA PF04670.12 EEA24328.1 - 2.2e-92 308.6 0.1 2.6e-92 308.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EEA24328.1 - 1.3e-08 34.5 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA24328.1 - 1.3e-08 35.0 0.0 2.5e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EEA24328.1 - 8.4e-08 32.0 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EEA24328.1 - 4.3e-07 30.0 0.0 7.3e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EEA24328.1 - 0.0017 17.6 2.3 0.49 9.5 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 EEA24328.1 - 0.0052 16.3 0.0 0.0083 15.7 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 EEA24328.1 - 0.0089 15.8 0.5 0.049 13.4 0.2 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF815 PF05673.13 EEA24328.1 - 0.014 14.6 0.1 0.023 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 EEA24328.1 - 0.017 15.6 0.0 0.037 14.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EEA24328.1 - 0.018 15.0 0.2 0.44 10.4 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase AIG1 PF04548.16 EEA24328.1 - 0.018 14.3 0.2 0.51 9.6 0.0 2.4 2 0 0 2 2 2 0 AIG1 family MMR_HSR1_Xtn PF16897.5 EEA24328.1 - 0.029 14.4 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_7 PF12775.7 EEA24328.1 - 0.079 12.5 0.1 0.19 11.2 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF1688 PF07958.11 EEA24329.1 - 1.9e-184 613.2 0.0 2.2e-184 613.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) TPR_2 PF07719.17 EEA24330.1 - 6.1e-07 29.1 0.5 0.011 15.8 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 EEA24330.1 - 8.5e-05 22.4 0.0 0.0003 20.6 0.0 2.0 1 0 0 1 1 1 1 UBA/TS-N domain TPR_1 PF00515.28 EEA24330.1 - 0.00057 19.6 0.3 0.77 9.7 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24330.1 - 0.0041 17.4 0.0 0.13 12.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24330.1 - 0.011 16.4 0.2 2.6 8.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DnaJ PF00226.31 EEA24330.1 - 0.043 14.0 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain GCD14 PF08704.10 EEA24331.1 - 2.5e-61 207.5 2.4 1.1e-56 192.3 0.1 2.9 1 1 1 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_24 PF13578.6 EEA24331.1 - 0.15 13.1 0.3 1 10.4 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain CCDC53 PF10152.9 EEA24331.1 - 0.32 11.4 4.4 0.64 10.4 4.4 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Chorion_2 PF03964.15 EEA24331.1 - 3.4 8.6 8.0 0.81 10.6 1.2 2.5 2 0 0 2 2 2 0 Chorion family 2 tRNA-synt_1e PF01406.19 EEA24332.1 - 3.4e-115 384.6 0.0 5.7e-115 383.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DALR_2 PF09190.11 EEA24332.1 - 5.3e-06 26.8 0.1 1.7e-05 25.2 0.1 1.9 1 0 0 1 1 1 1 DALR domain tRNA-synt_1g PF09334.11 EEA24332.1 - 4.2e-05 22.5 0.9 0.23 10.2 0.1 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 EEA24332.1 - 0.015 14.2 0.1 0.87 8.4 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) 40S_SA_C PF16122.5 EEA24332.1 - 4.3 8.8 7.0 5.9 8.3 3.5 3.0 2 0 0 2 2 2 0 40S ribosomal protein SA C-terminus SGS PF05002.15 EEA24333.1 - 2.7e-29 101.1 7.8 1.1e-28 99.2 7.8 2.1 1 1 0 1 1 1 1 SGS domain CS PF04969.16 EEA24333.1 - 2.9e-16 60.2 1.3 1.4e-15 58.0 0.2 2.3 2 0 0 2 2 2 1 CS domain TPR_16 PF13432.6 EEA24333.1 - 0.0018 18.9 4.5 0.084 13.5 0.7 3.1 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF4887 PF16228.5 EEA24333.1 - 0.047 13.9 5.8 0.12 12.6 5.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) TPR_11 PF13414.6 EEA24333.1 - 0.13 12.0 0.2 0.38 10.5 0.0 1.9 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.17 EEA24333.1 - 0.19 12.0 0.3 25 5.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PQ-loop PF04193.14 EEA24334.1 - 1.2e-40 137.1 12.5 2.7e-21 75.1 1.5 2.7 2 0 0 2 2 2 2 PQ loop repeat TAL_FSA PF00923.19 EEA24335.1 - 1.4e-44 152.6 0.0 1.7e-44 152.3 0.0 1.1 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Peptidase_S39 PF02122.15 EEA24335.1 - 0.048 13.2 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase S39 TAL_FSA PF00923.19 EEA24336.1 - 4.4e-41 141.1 0.0 5.5e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Peptidase_S39 PF02122.15 EEA24336.1 - 0.033 13.7 0.0 0.047 13.2 0.0 1.1 1 0 0 1 1 1 0 Peptidase S39 SQHop_cyclase_C PF13243.6 EEA24337.1 - 1.8e-51 175.2 0.1 9.8e-49 166.2 0.2 2.3 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EEA24337.1 - 2.5e-46 158.1 1.7 3.9e-39 134.5 0.3 3.4 2 1 1 3 3 3 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EEA24337.1 - 1.8e-32 110.7 6.2 1.5e-09 37.4 0.1 5.7 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EEA24337.1 - 4.7e-06 26.1 0.6 0.17 11.2 0.1 4.8 2 1 3 5 5 5 2 Pectic acid lyase TED_complement PF07678.14 EEA24337.1 - 3.2e-05 23.1 0.0 0.015 14.4 0.1 3.3 2 1 1 3 3 3 1 A-macroglobulin TED domain LPD16 PF18830.1 EEA24337.1 - 0.14 12.2 0.0 0.5 10.3 0.0 1.9 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 16 TP6A_N PF04406.14 EEA24338.1 - 2.8e-21 75.3 0.0 5.1e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Flavi_M PF01004.19 EEA24338.1 - 0.024 14.4 0.0 0.081 12.7 0.0 1.8 2 0 0 2 2 2 0 Flavivirus envelope glycoprotein M UQ_con PF00179.26 EEA24339.1 - 1.8e-50 170.2 0.0 2.1e-50 170.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ribosomal_L27 PF01016.19 EEA24341.1 - 3.7e-28 97.4 0.0 7.7e-28 96.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L27 protein Rad9_Rad53_bind PF08605.10 EEA24342.1 - 9.2e-23 80.8 0.0 1.6e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding Tudor_3 PF18115.1 EEA24342.1 - 2e-16 59.5 0.2 6.5e-16 57.9 0.1 2.0 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain BRCT_2 PF16589.5 EEA24342.1 - 7.1e-09 36.0 0.0 2.2e-08 34.4 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EEA24342.1 - 2e-06 28.1 0.0 5.5e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EEA24342.1 - 6.4e-06 26.0 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain tRNA_int_endo PF01974.17 EEA24343.1 - 6.7e-21 74.2 0.1 1.7e-20 72.8 0.1 1.7 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EEA24343.1 - 0.0029 17.3 0.0 0.14 11.8 0.0 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain LAT PF15234.6 EEA24343.1 - 0.12 12.1 1.5 0.23 11.1 1.5 1.4 1 0 0 1 1 1 0 Linker for activation of T-cells Nop10p PF04135.12 EEA24344.1 - 3.9e-22 78.0 0.8 4.6e-22 77.8 0.8 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family NOB1_Zn_bind PF08772.11 EEA24345.1 - 5.8e-32 109.7 3.8 1e-31 108.9 3.8 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EEA24345.1 - 1.9e-30 105.2 0.1 7.5e-30 103.3 0.1 2.1 1 0 0 1 1 1 1 PIN domain of ribonuclease zinc_ribbon_15 PF17032.5 EEA24345.1 - 0.032 15.0 0.6 0.06 14.1 0.6 1.4 1 0 0 1 1 1 0 zinc-ribbon family DZR PF12773.7 EEA24345.1 - 0.046 13.7 0.8 0.088 12.8 0.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-NADH-PPase PF09297.11 EEA24345.1 - 0.081 12.6 1.9 0.35 10.6 0.3 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain HypA PF01155.19 EEA24345.1 - 0.17 11.9 1.2 1.3 9.1 1.4 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2321 PF10083.9 EEA24345.1 - 0.17 11.5 4.1 0.19 11.3 0.5 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) COMP PF11598.8 EEA24345.1 - 0.19 12.2 4.3 6.7 7.3 0.3 3.1 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein RecR PF02132.15 EEA24345.1 - 0.42 10.2 2.5 1.3 8.6 2.5 1.8 1 1 0 1 1 1 0 RecR protein Zn-ribbon_8 PF09723.10 EEA24345.1 - 1.9 8.7 5.1 0.62 10.2 1.9 1.9 2 0 0 2 2 2 0 Zinc ribbon domain PHO4 PF01384.20 EEA24346.1 - 3.7 6.5 10.4 7.5 5.5 10.1 1.6 1 1 1 2 2 2 0 Phosphate transporter family Peptidase_M18 PF02127.15 EEA24347.1 - 8.2e-134 446.6 0.0 9.5e-134 446.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Glyco_hydro_71 PF03659.14 EEA24348.1 - 5.7e-138 459.8 5.3 5.7e-138 459.8 5.3 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 LysM PF01476.20 EEA24349.1 - 3.3e-26 91.1 0.0 1.8e-05 24.7 0.0 4.2 4 0 0 4 4 4 4 LysM domain DUF1153 PF06627.11 EEA24349.1 - 0.014 15.6 0.0 0.91 9.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1153) DUF1983 PF09327.11 EEA24349.1 - 0.027 14.5 0.1 5.8 7.1 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1983) HTH_28 PF13518.6 EEA24349.1 - 0.037 14.2 0.0 26 5.0 0.0 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain Ribosomal_L12_N PF16320.5 EEA24349.1 - 0.21 11.4 0.0 16 5.3 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain Kdo PF06293.14 EEA24350.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MFS_1 PF07690.16 EEA24351.1 - 5.2e-32 111.1 27.9 6.9e-32 110.7 27.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA24351.1 - 7.6e-05 22.2 3.2 7.6e-05 22.2 3.2 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB ABC2_membrane PF01061.24 EEA24352.1 - 3.6e-78 261.8 54.4 2.5e-40 138.1 24.9 3.0 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EEA24352.1 - 1.5e-36 125.9 0.0 5.1e-17 62.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EEA24352.1 - 1.2e-26 92.4 0.7 2.3e-20 72.3 0.0 3.4 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EEA24352.1 - 1.5e-13 51.1 0.0 1.2e-12 48.3 0.0 2.4 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_21 PF13304.6 EEA24352.1 - 5.6e-06 26.4 0.0 0.086 12.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EEA24352.1 - 9.8e-06 26.0 0.1 0.035 14.5 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EEA24352.1 - 0.00012 21.7 0.1 0.011 15.4 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EEA24352.1 - 0.00013 21.7 0.0 0.0066 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EEA24352.1 - 0.00013 21.9 0.1 0.0007 19.5 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EEA24352.1 - 0.00021 21.5 0.0 0.0073 16.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA24352.1 - 0.00029 21.4 0.1 0.012 16.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_17 PF13207.6 EEA24352.1 - 0.0017 18.8 0.2 0.18 12.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EEA24352.1 - 0.015 14.9 1.4 0.24 11.0 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EEA24352.1 - 0.018 14.7 0.7 2.4 7.8 0.3 2.5 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EEA24352.1 - 0.02 14.4 1.8 0.26 10.7 0.0 3.2 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA24352.1 - 0.021 15.1 0.7 0.76 10.0 0.1 3.0 3 1 0 3 3 2 0 AAA domain AAA_28 PF13521.6 EEA24352.1 - 0.065 13.5 1.0 0.19 12.0 0.2 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EEA24352.1 - 0.11 12.4 0.9 7.6 6.4 0.3 2.4 2 0 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.23 EEA24352.1 - 0.12 12.5 0.3 12 6.0 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase DnaB_C PF03796.15 EEA24352.1 - 0.18 11.1 0.0 8.6 5.6 0.0 2.4 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain PduV-EutP PF10662.9 EEA24352.1 - 0.28 10.9 0.8 8.5 6.1 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 EEA24352.1 - 0.33 11.4 0.1 0.33 11.4 0.1 4.1 4 1 0 4 4 3 0 AAA domain ABC2_membrane_3 PF12698.7 EEA24352.1 - 0.82 8.7 46.8 0.083 12.0 23.9 3.8 3 2 1 4 4 4 0 ABC-2 family transporter protein Meth_synt_2 PF01717.18 EEA24353.1 - 8.3e-148 491.9 0.0 6.3e-144 479.2 0.0 2.5 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EEA24353.1 - 3.8e-118 394.6 0.0 8.4e-112 373.7 0.0 2.8 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 EEA24353.1 - 4.7e-05 22.7 0.0 0.0099 15.1 0.0 2.5 2 0 0 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) DUF4947 PF16305.5 EEA24353.1 - 0.087 12.8 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4947) Glyco_hydro_72 PF03198.14 EEA24354.1 - 5.5e-120 400.4 10.2 7.9e-120 399.9 10.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EEA24354.1 - 8.8e-21 74.4 1.8 2.9e-20 72.7 1.8 2.0 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 EEA24354.1 - 0.0016 17.9 2.9 0.0037 16.7 2.9 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EEA24354.1 - 0.002 17.3 0.1 0.0055 15.9 0.5 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain fn2 PF00040.19 EEA24354.1 - 0.11 12.8 0.6 0.42 10.9 0.6 2.0 1 0 0 1 1 1 0 Fibronectin type II domain NmrA PF05368.13 EEA24355.1 - 5.4e-29 101.4 0.0 7.1e-29 101.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA24355.1 - 2.6e-23 82.8 0.0 3.7e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EEA24355.1 - 1e-06 29.0 0.0 1.9e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EEA24355.1 - 6.3e-05 23.4 0.0 0.00011 22.6 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EEA24355.1 - 0.00023 21.2 0.0 0.00065 19.8 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EEA24355.1 - 0.0019 17.7 0.1 0.015 14.8 0.0 2.3 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family CbiJ PF02571.14 EEA24355.1 - 0.0055 16.2 0.0 0.0093 15.5 0.0 1.3 1 0 0 1 1 1 1 Precorrin-6x reductase CbiJ/CobK KR PF08659.10 EEA24355.1 - 0.036 14.0 0.1 0.062 13.2 0.1 1.4 1 0 0 1 1 1 0 KR domain TrkA_N PF02254.18 EEA24355.1 - 0.049 13.9 0.0 0.097 12.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain DapB_N PF01113.20 EEA24355.1 - 0.055 13.6 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EEA24355.1 - 0.092 13.3 0.2 0.2 12.3 0.2 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 EEA24355.1 - 0.16 11.5 0.1 0.26 10.7 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DUF3759 PF12585.8 EEA24356.1 - 1.4e-40 137.2 3.7 1.7e-40 137.0 3.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) Abhydrolase_2 PF02230.16 EEA24357.1 - 4.3e-11 43.0 0.0 2.8e-09 37.1 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Presenilin PF01080.17 EEA24358.1 - 0.74 8.5 5.1 1.4 7.6 5.1 1.4 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 EEA24358.1 - 1.2 8.4 5.0 1.8 7.8 5.0 1.2 1 0 0 1 1 1 0 NOA36 protein NST1 PF13945.6 EEA24358.1 - 1.3 9.1 23.7 2.8 8.0 23.7 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator NPR3 PF03666.13 EEA24358.1 - 4.4 6.0 8.4 6.7 5.4 8.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 EEA24358.1 - 4.5 5.5 15.9 0.92 7.8 12.0 1.8 2 0 0 2 2 2 0 Menin DUF2076 PF09849.9 EEA24358.1 - 9.6 6.2 13.0 18 5.3 13.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Metallophos PF00149.28 EEA24359.1 - 3e-36 125.8 0.1 5e-36 125.1 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 EEA24359.1 - 0.045 13.5 1.1 2.1 8.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) NopRA1 PF16201.5 EEA24360.1 - 0.012 15.2 0.2 0.021 14.4 0.2 1.3 1 0 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 Glycos_transf_2 PF00535.26 EEA24361.1 - 6e-22 78.2 0.0 1.4e-20 73.8 0.0 2.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EEA24361.1 - 3e-06 27.3 0.0 0.0063 16.4 0.0 2.7 3 0 0 3 3 3 2 Glycosyltransferase like family 2 STE3 PF02076.15 EEA24361.1 - 0.086 12.0 1.4 0.14 11.4 1.4 1.2 1 0 0 1 1 1 0 Pheromone A receptor WD40 PF00400.32 EEA24362.1 - 3.3e-21 75.2 4.5 1.1e-06 29.2 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24362.1 - 2.1e-08 34.3 0.4 0.098 13.0 0.0 3.9 3 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Me-amine-dh_H PF06433.11 EEA24362.1 - 0.00023 20.1 0.0 0.13 11.2 0.0 2.1 2 0 0 2 2 2 2 Methylamine dehydrogenase heavy chain (MADH) Nup160 PF11715.8 EEA24362.1 - 0.00068 18.4 0.2 0.59 8.7 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EEA24362.1 - 0.0067 15.4 0.0 0.74 8.7 0.0 2.5 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein RRM_1 PF00076.22 EEA24363.1 - 3.1e-16 58.9 0.0 5.7e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EEA24363.1 - 1.5e-08 35.0 13.1 1.5e-08 35.0 13.1 4.6 5 0 0 5 5 5 2 C-terminal duplication domain of Friend of PRMT1 CH PF00307.31 EEA24364.1 - 5.6e-47 158.4 0.4 1.4e-22 79.9 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EEA24364.1 - 1.2e-26 92.6 0.5 3.1e-26 91.2 0.1 2.0 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EEA24364.1 - 5e-10 39.1 0.4 6.2e-07 29.2 0.1 2.8 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 EEA24364.1 - 3.7e-05 23.3 0.1 0.00055 19.7 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EEA24364.1 - 0.00013 21.3 0.1 0.0063 16.0 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EEA24364.1 - 0.00025 20.8 0.4 0.0013 18.6 0.0 2.4 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 EEA24364.1 - 0.0079 16.6 0.4 0.0079 16.6 0.4 3.0 4 0 0 4 4 3 1 EF-hand domain pair CH_2 PF06294.11 EEA24364.1 - 0.013 15.6 0.0 0.66 10.1 0.0 2.9 2 0 0 2 2 2 0 CH-like domain in sperm protein Spectrin PF00435.21 EEA24364.1 - 0.052 14.0 0.0 0.052 14.0 0.0 3.0 2 1 0 3 3 3 0 Spectrin repeat DUF641 PF04859.12 EEA24364.1 - 0.55 10.6 2.9 42 4.5 0.1 3.4 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) FliG_N PF14842.6 EEA24364.1 - 0.67 10.5 2.8 3.3 8.3 0.1 3.1 2 1 0 3 3 3 0 FliG N-terminal domain Baculo_PEP_C PF04513.12 EEA24364.1 - 5.2 7.1 6.1 1.2 9.1 0.5 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Aldo_ket_red PF00248.21 EEA24365.1 - 8.5e-44 149.9 0.0 2.8e-32 112.1 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Rit1_C PF17184.4 EEA24366.1 - 4.8e-99 331.2 0.0 6e-99 330.9 0.0 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EEA24366.1 - 3e-37 127.3 0.0 1.7e-36 124.8 0.0 2.1 2 0 0 2 2 2 1 Rit1 DUSP-like domain HAD_2 PF13419.6 EEA24367.1 - 1e-21 77.8 0.1 1.5e-21 77.3 0.1 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA24367.1 - 1.2e-10 42.0 0.2 4e-10 40.3 0.2 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA24367.1 - 1.1e-06 28.6 0.1 2e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.18 EEA24367.1 - 4.6e-05 23.2 0.0 0.0042 16.9 0.0 2.2 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase DDE_3 PF13358.6 EEA24368.1 - 2.1e-16 60.0 0.0 3.7e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 EEA24368.1 - 2.1e-06 28.2 5.0 0.0048 17.5 0.1 2.5 1 1 1 2 2 2 2 Homeodomain-like domain rve PF00665.26 EEA24368.1 - 0.14 12.4 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain NUDIX PF00293.28 EEA24369.1 - 4.9e-17 62.2 0.0 8.7e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 EEA24370.1 - 2e-05 24.7 0.0 5.5e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain EST1_DNA_bind PF10373.9 EEA24372.1 - 1.8e-13 50.6 0.1 3e-12 46.6 0.0 2.4 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain K_trans PF02705.16 EEA24373.1 - 2e-184 614.1 20.6 2.6e-184 613.7 20.6 1.1 1 0 0 1 1 1 1 K+ potassium transporter Striatin PF08232.12 EEA24374.1 - 0.0069 17.0 0.9 0.02 15.5 0.9 1.8 1 0 0 1 1 1 1 Striatin family Fez1 PF06818.15 EEA24374.1 - 0.012 16.1 0.7 0.019 15.4 0.7 1.3 1 0 0 1 1 1 0 Fez1 Autophagy_N PF03986.13 EEA24376.1 - 3.4e-45 153.3 0.2 3.4e-45 153.3 0.2 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 EEA24376.1 - 1.2e-15 56.7 0.7 2.4e-15 55.7 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 EEA24376.1 - 9.9e-14 51.7 0.7 1.9e-13 50.8 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain TFIIB PF00382.19 EEA24377.1 - 0.1 12.7 0.0 4.2 7.5 0.0 2.6 2 1 0 2 2 2 0 Transcription factor TFIIB repeat MUG113 PF13455.6 EEA24378.1 - 4.2e-28 97.8 0.3 9.3e-28 96.7 0.3 1.6 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EEA24378.1 - 1.1e-26 93.3 0.1 1.1e-26 93.3 0.1 2.2 2 1 0 2 2 2 1 T5orf172 domain Promethin PF16015.5 EEA24379.1 - 4.1e-29 100.6 7.9 7.7e-29 99.7 7.9 1.5 1 0 0 1 1 1 1 Promethin IBN_N PF03810.19 EEA24379.1 - 0.031 14.2 0.2 0.065 13.2 0.2 1.5 1 0 0 1 1 1 0 Importin-beta N-terminal domain DUF4191 PF13829.6 EEA24379.1 - 0.16 11.3 0.4 0.36 10.1 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) SecY PF00344.20 EEA24380.1 - 5.4e-73 245.9 6.4 6.7e-73 245.6 6.4 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EEA24380.1 - 2.3e-17 62.5 0.3 6e-17 61.2 0.3 1.8 1 0 0 1 1 1 1 Plug domain of Sec61p ArgJ PF01960.18 EEA24381.1 - 1.1e-147 491.7 0.2 1.2e-147 491.5 0.2 1.0 1 0 0 1 1 1 1 ArgJ family ORC2 PF04084.14 EEA24382.1 - 2.7e-118 394.7 0.0 3.4e-118 394.4 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 ORC6 PF05460.13 EEA24382.1 - 0.36 10.1 4.3 0.62 9.3 4.3 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Pox_Ag35 PF03286.14 EEA24382.1 - 4.5 7.0 8.0 9.2 6.0 8.0 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FUN14 PF04930.15 EEA24383.1 - 4.8e-10 39.7 1.0 9.7e-10 38.7 1.0 1.5 1 0 0 1 1 1 1 FUN14 family DsbD PF02683.15 EEA24383.1 - 0.026 14.4 0.9 0.04 13.8 0.5 1.5 1 1 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region SOR_SNZ PF01680.17 EEA24384.1 - 1.5e-108 361.3 4.6 2.1e-108 360.9 4.6 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EEA24384.1 - 3.3e-09 36.4 5.1 1.7e-06 27.6 0.0 2.5 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG TetR_C_27 PF17935.1 EEA24384.1 - 0.0015 18.5 0.0 0.0046 17.0 0.0 1.7 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Dus PF01207.17 EEA24384.1 - 0.0022 17.2 0.6 0.42 9.6 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.21 EEA24384.1 - 0.0025 17.0 0.0 0.16 11.1 0.0 2.3 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase His_biosynth PF00977.21 EEA24384.1 - 0.0027 17.2 0.1 0.03 13.8 0.0 2.4 2 2 0 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 EEA24384.1 - 0.0093 15.2 0.5 0.16 11.1 0.0 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase IBN_N PF03810.19 EEA24385.1 - 1.4e-06 28.1 0.1 5.4e-06 26.2 0.1 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Importin_rep PF18773.1 EEA24385.1 - 0.0003 20.4 1.5 0.00063 19.4 1.5 1.6 1 0 0 1 1 1 1 Importin 13 repeat Importin_rep_3 PF18806.1 EEA24385.1 - 0.0031 17.5 0.0 0.014 15.5 0.0 2.1 1 0 0 1 1 1 1 Importin 13 repeat CSN7a_helixI PF18392.1 EEA24385.1 - 0.13 12.1 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain Creatinase_N_2 PF16189.5 EEA24386.1 - 1.5e-52 178.0 0.1 1e-50 172.0 0.0 2.4 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EEA24386.1 - 9.1e-43 146.4 0.0 3.4e-42 144.5 0.0 1.8 2 0 0 2 2 2 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EEA24386.1 - 6.9e-23 80.5 0.6 1.8e-22 79.2 0.6 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EEA24386.1 - 5.2e-20 72.4 0.0 2.4e-18 67.1 0.0 2.4 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Sec8_exocyst PF04048.14 EEA24387.1 - 1.2e-45 154.9 2.2 1.2e-45 154.9 2.2 2.2 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EEA24387.1 - 6.1e-10 38.9 3.0 1.1e-09 38.0 3.0 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Zw10 PF06248.13 EEA24387.1 - 0.00013 20.7 2.2 0.00026 19.7 2.2 1.4 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Dor1 PF04124.12 EEA24387.1 - 0.0012 17.6 5.9 0.0029 16.3 5.9 1.6 1 0 0 1 1 1 1 Dor1-like family DUF3405 PF11885.8 EEA24388.1 - 3e-172 573.9 1.6 3e-172 573.9 1.6 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3405) Cutinase PF01083.22 EEA24389.1 - 3.2e-44 151.0 0.5 4e-44 150.7 0.5 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EEA24389.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain Baculo_PEP_C PF04513.12 EEA24389.1 - 0.04 14.0 3.7 0.075 13.1 3.7 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus VirJ PF06057.11 EEA24389.1 - 0.071 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_9 PF10081.9 EEA24389.1 - 0.17 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family ABC_membrane PF00664.23 EEA24390.1 - 1e-63 215.6 40.0 9e-39 133.8 16.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA24390.1 - 4.5e-49 166.5 0.6 5.3e-30 104.7 0.2 2.9 2 0 0 2 2 2 2 ABC transporter MMR_HSR1 PF01926.23 EEA24390.1 - 5e-05 23.4 1.3 0.011 15.9 0.1 3.0 3 0 0 3 3 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 EEA24390.1 - 7.3e-05 22.3 4.3 2.4 7.5 0.1 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA24390.1 - 0.00024 20.8 0.2 0.048 13.4 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA24390.1 - 0.001 19.6 0.2 0.043 14.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EEA24390.1 - 0.0026 17.7 0.5 1 9.3 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase Orthoreo_P10 PF07204.11 EEA24390.1 - 0.0042 17.0 1.1 0.41 10.6 0.2 2.7 2 0 0 2 2 2 1 Orthoreovirus membrane fusion protein p10 AAA_16 PF13191.6 EEA24390.1 - 0.0048 17.3 0.1 4.6 7.6 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 EEA24390.1 - 0.0074 16.4 4.5 0.33 11.0 0.0 2.9 3 0 0 3 3 2 1 Helicase HerA, central domain ATP-synt_ab PF00006.25 EEA24390.1 - 0.0081 15.8 0.1 4.3 6.9 0.0 2.4 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain TrwB_AAD_bind PF10412.9 EEA24390.1 - 0.01 14.8 1.0 2.8 6.8 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 EEA24390.1 - 0.012 14.9 0.0 1.2 8.5 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.6 EEA24390.1 - 0.012 15.3 0.7 1.6 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EEA24390.1 - 0.015 15.1 4.5 0.57 9.9 0.1 3.7 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 EEA24390.1 - 0.015 14.9 3.9 0.26 10.8 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EEA24390.1 - 0.016 14.8 0.2 0.59 9.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_15 PF13175.6 EEA24390.1 - 0.025 14.3 1.2 0.36 10.5 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.23 EEA24390.1 - 0.027 14.6 3.4 1.4 9.0 1.1 2.8 2 0 0 2 2 2 0 Dynamin family Zeta_toxin PF06414.12 EEA24390.1 - 0.027 13.8 0.1 5.3 6.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EEA24390.1 - 0.052 13.1 0.1 11 5.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 EEA24390.1 - 0.054 13.0 0.3 4 6.8 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_22 PF13401.6 EEA24390.1 - 0.061 13.6 0.1 7.2 6.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EEA24390.1 - 0.095 11.7 1.2 0.61 9.0 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 EEA24390.1 - 0.16 11.7 1.8 8.2 6.1 0.2 2.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SRP54 PF00448.22 EEA24390.1 - 0.18 11.4 1.5 12 5.5 0.2 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NACHT PF05729.12 EEA24390.1 - 0.35 10.8 1.2 5.7 6.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Orf78 PF06024.12 EEA24390.1 - 0.41 11.0 1.9 2.3 8.5 0.2 3.1 2 0 0 2 2 2 0 Orf78 (ac78) HLH PF00010.26 EEA24391.1 - 2.3e-13 49.9 1.8 4.6e-13 48.9 1.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Propeptide_C1 PF08127.13 EEA24391.1 - 0.064 13.2 0.2 0.16 11.9 0.2 1.7 1 0 0 1 1 1 0 Peptidase family C1 propeptide DUF1281 PF06924.11 EEA24391.1 - 0.15 11.6 0.9 0.29 10.7 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) CN_hydrolase PF00795.22 EEA24392.1 - 5.8e-09 35.7 0.0 8.8e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase SAC3_GANP PF03399.16 EEA24393.1 - 1e-104 350.1 2.8 1.7e-104 349.4 2.8 1.3 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EEA24393.1 - 0.0001 22.3 0.1 0.00075 19.5 0.1 2.3 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family ssDNA-exonuc_C PF10141.9 EEA24393.1 - 0.012 15.2 0.2 0.029 14.0 0.2 1.5 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain PfkB PF00294.24 EEA24394.1 - 7.7e-21 74.7 0.0 1e-20 74.3 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Sec20 PF03908.13 EEA24394.1 - 0.12 12.3 0.1 0.28 11.1 0.1 1.6 1 0 0 1 1 1 0 Sec20 ABC_membrane PF00664.23 EEA24395.1 - 1e-81 274.6 27.0 1.7e-43 149.3 11.3 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA24395.1 - 1.1e-53 181.4 0.1 5.5e-31 107.9 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EEA24395.1 - 7e-11 42.0 6.7 0.00075 19.0 0.1 4.9 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EEA24395.1 - 1.4e-06 28.3 0.1 0.054 13.6 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EEA24395.1 - 9.5e-06 26.1 1.0 0.12 12.8 0.3 3.2 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA24395.1 - 3.5e-05 23.8 0.0 0.027 14.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EEA24395.1 - 4.8e-05 23.0 0.1 0.078 12.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA24395.1 - 5.4e-05 23.8 0.2 0.007 16.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain MTABC_N PF16185.5 EEA24395.1 - 0.00014 21.5 5.9 0.00036 20.1 5.9 1.8 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region AAA_21 PF13304.6 EEA24395.1 - 0.00024 21.0 1.4 0.04 13.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EEA24395.1 - 0.001 18.9 0.1 0.18 11.5 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EEA24395.1 - 0.0012 18.6 1.0 0.079 12.7 0.0 3.4 2 1 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EEA24395.1 - 0.0017 18.4 0.4 0.22 11.5 0.0 2.5 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.17 EEA24395.1 - 0.014 15.5 0.8 1.8 8.6 0.1 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 EEA24395.1 - 0.018 15.5 0.0 1.6 9.2 0.0 2.7 2 0 0 2 2 2 0 RNA helicase T2SSE PF00437.20 EEA24395.1 - 0.021 13.9 0.1 3.2 6.7 0.0 3.0 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_22 PF13401.6 EEA24395.1 - 0.03 14.6 1.5 3.2 8.0 0.0 3.3 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 EEA24395.1 - 0.082 13.1 0.2 15 5.8 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EEA24395.1 - 0.17 11.6 1.4 6.5 6.4 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 EEA24395.1 - 0.18 11.1 0.0 3.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.12 EEA24395.1 - 1.1 9.1 6.1 0.5 10.3 0.1 2.9 3 0 0 3 3 3 0 NACHT domain DUF2841 PF11001.8 EEA24396.1 - 3.3e-41 140.2 0.1 4.6e-41 139.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Fungal_trans_2 PF11951.8 EEA24397.1 - 2.5e-21 75.9 1.7 5.3e-21 74.9 1.7 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24397.1 - 1.2e-07 31.7 9.4 2.1e-07 31.0 9.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHDPS PF00701.22 EEA24398.1 - 5.2e-35 120.6 0.0 1.6e-34 119.0 0.0 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family bVLRF1 PF18826.1 EEA24399.1 - 3.8e-65 218.3 0.7 1.1e-64 216.8 0.7 1.8 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EEA24399.1 - 3.4e-05 24.0 0.2 9.2e-05 22.7 0.1 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) zf-C2H2_2 PF12756.7 EEA24399.1 - 0.018 15.3 0.1 0.039 14.3 0.1 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Ank PF00023.30 EEA24399.1 - 0.2 12.2 0.3 0.49 10.9 0.3 1.7 1 0 0 1 1 1 0 Ankyrin repeat Pkinase PF00069.25 EEA24400.1 - 1.3e-58 198.4 0.0 2e-58 197.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24400.1 - 1.9e-27 96.2 0.0 2.9e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EEA24400.1 - 5.6e-11 42.6 0.1 1.3e-10 41.5 0.1 1.7 1 0 0 1 1 1 1 FHA domain Kdo PF06293.14 EEA24400.1 - 0.00025 20.5 0.0 0.00044 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA24400.1 - 0.00063 18.6 3.7 0.00081 18.3 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EEA24400.1 - 0.00091 18.6 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 EEA24400.1 - 0.0075 15.8 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Yop-YscD_cpl PF16697.5 EEA24400.1 - 0.024 14.9 0.0 0.23 11.8 0.0 2.4 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain APH PF01636.23 EEA24400.1 - 0.11 12.4 0.5 0.18 11.7 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Myb_DNA-bind_6 PF13921.6 EEA24401.1 - 0.00098 19.3 0.2 0.0019 18.4 0.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA24401.1 - 0.0017 18.5 0.9 0.0027 17.8 0.9 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain SOG2 PF10428.9 EEA24401.1 - 0.02 14.1 5.4 0.025 13.8 5.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein LIN37 PF15306.6 EEA24401.1 - 0.046 13.9 0.0 0.046 13.9 0.0 2.1 2 1 0 2 2 2 0 LIN37 Cys_Met_Meta_PP PF01053.20 EEA24402.1 - 8.2e-28 97.0 0.0 1.2e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Lysine_decarbox PF03641.14 EEA24403.1 - 2e-29 102.3 0.0 2.7e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EEA24403.1 - 7.4e-08 32.1 0.6 1.6e-07 31.0 0.6 1.8 1 1 0 1 1 1 1 SLOG cluster4 family MFS_1 PF07690.16 EEA24405.1 - 2.9e-56 190.9 57.9 1.4e-50 172.3 45.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA24405.1 - 1.1e-25 90.2 21.0 1.7e-25 89.5 21.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA24405.1 - 2.2e-15 56.5 7.0 2.2e-15 56.5 7.0 3.9 3 1 1 4 4 4 2 Sugar (and other) transporter MFS_3 PF05977.13 EEA24405.1 - 7.1e-05 21.4 11.8 0.0064 14.9 4.0 2.4 2 0 0 2 2 2 2 Transmembrane secretion effector OATP PF03137.20 EEA24405.1 - 0.33 9.2 16.7 0.033 12.5 0.2 3.4 2 2 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family ATP-grasp_4 PF13535.6 EEA24406.1 - 3.5e-11 43.0 0.0 1.1e-10 41.4 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_N PF18130.1 EEA24406.1 - 1.4e-08 35.2 0.0 2.7e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp N-terminal domain Dala_Dala_lig_C PF07478.13 EEA24406.1 - 0.00065 19.3 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EEA24406.1 - 0.034 14.2 0.0 0.5 10.4 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Adap_comp_sub PF00928.21 EEA24407.1 - 3.8e-83 278.9 0.0 4.7e-83 278.6 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EEA24407.1 - 7.3e-06 26.0 0.2 1.3e-05 25.2 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EEA24407.1 - 0.034 13.6 0.1 0.058 12.8 0.1 1.4 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Erf4 PF10256.9 EEA24408.1 - 6.8e-39 132.6 0.0 1e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Oxidored_FMN PF00724.20 EEA24409.1 - 2e-63 214.7 0.0 2.4e-63 214.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family FliT PF05400.13 EEA24410.1 - 0.011 16.5 0.3 0.065 14.1 0.3 2.1 1 1 0 1 1 1 0 Flagellar protein FliT Dynamin_N PF00350.23 EEA24411.1 - 1.7e-14 54.2 0.0 1.7e-14 54.2 0.0 3.0 2 1 1 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EEA24411.1 - 1.9e-05 24.7 0.2 0.00047 20.2 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EEA24411.1 - 0.00026 21.5 1.0 0.00083 19.9 0.0 2.4 2 1 0 2 2 1 1 ABC transporter RsgA_GTPase PF03193.16 EEA24411.1 - 0.00048 20.1 0.0 0.0046 16.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 EEA24411.1 - 0.0054 16.0 0.2 0.023 14.0 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin IIGP PF05049.13 EEA24411.1 - 0.015 14.3 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 EEA24411.1 - 0.016 15.6 0.1 0.22 11.9 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain Chal_sti_synt_N PF00195.19 EEA24411.1 - 0.028 13.9 0.8 0.1 12.0 0.1 2.0 2 0 0 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain SMC_N PF02463.19 EEA24411.1 - 0.031 13.7 0.1 0.098 12.1 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain ING PF12998.7 EEA24411.1 - 0.043 14.4 6.7 2.5 8.8 0.4 4.0 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF3456 PF11938.8 EEA24411.1 - 0.046 14.2 7.6 0.23 11.9 0.3 3.9 3 0 0 3 3 3 0 TLR4 regulator and MIR-interacting MSAP 14-3-3 PF00244.20 EEA24411.1 - 0.058 12.9 11.8 0.22 11.0 1.7 2.8 3 0 0 3 3 2 0 14-3-3 protein AIG1 PF04548.16 EEA24411.1 - 0.059 12.7 0.0 0.16 11.3 0.0 1.8 1 0 0 1 1 1 0 AIG1 family AAA_22 PF13401.6 EEA24411.1 - 0.12 12.7 0.0 1.1 9.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Tsc35 PF15079.6 EEA24411.1 - 0.21 11.1 5.9 0.63 9.6 5.4 2.1 1 1 1 2 2 2 0 Testis-specific protein 35 AAA_23 PF13476.6 EEA24411.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.8 2 1 0 2 2 1 0 AAA domain Seryl_tRNA_N PF02403.22 EEA24411.1 - 1.3 9.3 9.5 7.5 6.8 1.6 3.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMF_TATA_bd PF12325.8 EEA24411.1 - 4.2 7.6 14.4 0.063 13.5 2.5 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Tex_N PF09371.10 EEA24411.1 - 8.2 6.1 9.7 0.79 9.4 4.0 2.2 2 0 0 2 2 2 0 Tex-like protein N-terminal domain WD40 PF00400.32 EEA24412.1 - 1.8e-17 63.4 6.0 1.3e-05 25.8 0.2 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24412.1 - 1.2e-06 28.8 0.0 0.0023 18.2 0.0 4.7 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA24412.1 - 0.059 12.7 0.0 0.094 12.0 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain Cpn60_TCP1 PF00118.24 EEA24413.1 - 2.9e-152 507.8 16.6 3.2e-152 507.6 16.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ProRS-C_1 PF09180.11 EEA24414.1 - 6.2e-23 80.8 0.2 1.4e-22 79.6 0.2 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EEA24414.1 - 1.1e-18 67.8 0.0 2.2e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EEA24414.1 - 2e-12 47.1 0.0 8.8e-12 45.0 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain RNase_PH PF01138.21 EEA24416.1 - 2.7e-31 108.8 0.0 4.4e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PEMT PF04191.13 EEA24417.1 - 1.5e-59 199.0 7.5 6.1e-36 123.0 0.7 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase SKICH PF17751.1 EEA24417.1 - 0.033 14.7 0.0 1.5 9.4 0.0 2.3 2 0 0 2 2 2 0 SKICH domain HECW_N PF16562.5 EEA24417.1 - 0.056 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 ParA PF10609.9 EEA24418.1 - 1.7e-93 312.6 0.0 2e-93 312.4 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EEA24418.1 - 9.3e-10 38.7 0.0 4.3e-09 36.5 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EEA24418.1 - 1.3e-06 28.5 0.0 1.5e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EEA24418.1 - 1.9e-06 27.3 0.5 4.7e-05 22.7 0.1 2.6 1 1 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 EEA24418.1 - 0.00057 19.4 0.0 0.45 9.9 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_26 PF13500.6 EEA24418.1 - 0.0023 17.8 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EEA24418.1 - 0.0064 16.2 0.0 0.009 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EEA24418.1 - 0.0079 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop RsgA_GTPase PF03193.16 EEA24418.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 EEA24418.1 - 0.034 14.1 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EEA24418.1 - 0.043 13.4 0.1 0.083 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 EEA24418.1 - 0.045 13.0 0.0 0.11 11.8 0.0 1.6 1 1 0 1 1 1 0 ATPase MipZ RNA_helicase PF00910.22 EEA24418.1 - 0.048 14.0 0.0 0.097 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EEA24418.1 - 0.11 12.9 0.0 0.17 12.2 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 EEA24418.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain TsaE PF02367.17 EEA24418.1 - 0.15 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EEA24418.1 - 0.17 11.1 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Asp PF00026.23 EEA24419.1 - 2.4e-66 224.3 11.9 3.4e-66 223.8 11.9 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA24419.1 - 1.3e-10 41.8 4.3 0.0001 22.6 0.0 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA24419.1 - 3.8e-09 37.1 4.8 0.00054 20.6 1.3 3.6 2 2 1 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EEA24419.1 - 0.00014 22.4 4.1 0.24 12.0 1.0 3.3 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EEA24419.1 - 0.0066 16.2 0.5 0.03 14.1 0.0 2.3 2 1 1 3 3 3 1 Xylanase inhibitor C-terminal tRNA_bind PF01588.20 EEA24420.1 - 1.6e-22 79.4 0.4 3.9e-21 75.0 0.0 2.9 2 1 0 2 2 2 1 Putative tRNA binding domain GST_C_2 PF13410.6 EEA24420.1 - 1e-05 25.5 0.0 2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA24420.1 - 0.0059 16.8 0.0 0.0059 16.8 0.0 3.4 3 1 0 3 3 3 1 Glutathione S-transferase, C-terminal domain Pol_alpha_B_N PF08418.10 EEA24420.1 - 0.0061 16.6 1.8 0.0061 16.6 1.8 1.5 2 0 0 2 2 2 1 DNA polymerase alpha subunit B N-terminal GST_C_6 PF17171.4 EEA24420.1 - 0.052 13.3 0.0 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA24420.1 - 0.29 11.3 0.0 0.29 11.3 0.0 2.2 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain Presenilin PF01080.17 EEA24420.1 - 3.6 6.2 5.0 5.5 5.6 5.0 1.2 1 0 0 1 1 1 0 Presenilin Anp1 PF03452.14 EEA24421.1 - 3.1e-112 374.3 0.8 4.4e-112 373.8 0.0 1.6 2 0 0 2 2 2 1 Anp1 Dcc1 PF09724.9 EEA24422.1 - 8.6e-21 74.6 0.0 1.4e-20 73.9 0.0 1.3 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Acetyltransf_9 PF13527.7 EEA24423.1 - 0.00055 20.0 0.1 0.0018 18.3 0.1 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA24423.1 - 0.0012 19.3 0.0 0.0028 18.0 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA24423.1 - 0.0096 15.9 0.0 0.05 13.6 0.0 2.2 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.7 EEA24423.1 - 0.018 15.0 0.1 0.16 11.9 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA24423.1 - 0.033 14.4 0.0 0.083 13.1 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family IBR PF01485.21 EEA24424.1 - 0.00035 20.8 3.7 0.00035 20.8 3.7 3.1 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain DUF4972 PF16342.5 EEA24424.1 - 0.091 12.4 0.1 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) HORMA PF02301.18 EEA24425.1 - 5.1e-08 32.8 0.0 7.7e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 HORMA domain Cas_Csm6 PF09659.10 EEA24425.1 - 0.2 10.4 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) IBN_N PF03810.19 EEA24426.1 - 2.5e-09 36.9 1.1 2.2e-07 30.7 0.1 4.0 3 2 1 4 4 4 1 Importin-beta N-terminal domain RICTOR_N PF14664.6 EEA24426.1 - 5.3e-05 22.4 1.4 0.00014 21.0 0.1 2.2 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, N-term CAS_CSE1 PF03378.15 EEA24426.1 - 0.00014 20.5 0.1 0.00046 18.8 0.1 1.9 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus RIX1 PF08167.12 EEA24426.1 - 0.00073 19.3 0.8 0.0033 17.2 0.0 2.6 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Xpo1 PF08389.12 EEA24426.1 - 0.0026 17.8 0.1 0.11 12.6 0.0 3.8 4 0 0 4 4 4 1 Exportin 1-like protein Mo25 PF08569.11 EEA24426.1 - 0.16 11.3 1.0 11 5.3 0.0 2.8 3 1 0 3 3 3 0 Mo25-like Zn_clus PF00172.18 EEA24427.1 - 4.6e-06 26.7 16.2 4.6e-06 26.7 16.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Uds1 PF15456.6 EEA24427.1 - 0.00067 19.8 2.6 0.00073 19.7 0.1 2.2 2 0 0 2 2 2 1 Up-regulated During Septation SlyX PF04102.12 EEA24427.1 - 0.049 14.3 0.9 0.11 13.2 0.9 1.5 1 0 0 1 1 1 0 SlyX SpoOE-like PF09388.10 EEA24427.1 - 0.05 13.5 0.5 0.1 12.5 0.5 1.5 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein GvpG PF05120.12 EEA24427.1 - 0.14 12.2 0.3 0.26 11.3 0.3 1.4 1 0 0 1 1 1 0 Gas vesicle protein G PhyH PF05721.13 EEA24428.1 - 1.4e-08 35.3 0.0 3.1e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Het-C PF07217.11 EEA24429.1 - 1.1e-276 918.9 0.0 1.7e-276 918.2 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C CS PF04969.16 EEA24430.1 - 8.5e-07 29.9 0.0 1.5e-06 29.1 0.0 1.4 1 1 0 1 1 1 1 CS domain CS PF04969.16 EEA24431.1 - 6.6e-07 30.3 0.0 1.2e-06 29.5 0.0 1.5 1 1 0 1 1 1 1 CS domain Ribosomal_L2_C PF03947.18 EEA24432.1 - 3.4e-41 140.4 5.7 3.4e-41 140.4 5.7 1.6 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EEA24432.1 - 1.8e-14 53.5 0.1 4.4e-14 52.2 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DUF3093 PF11292.8 EEA24432.1 - 0.18 12.1 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) Ribosomal_L2_C PF03947.18 EEA24433.1 - 6.5e-24 84.5 0.5 1.5e-23 83.3 0.2 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EEA24433.1 - 1.8e-14 53.4 0.1 3.3e-14 52.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DUF3093 PF11292.8 EEA24433.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) DDE_1 PF03184.19 EEA24434.1 - 3.2e-17 62.7 0.0 7e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA24434.1 - 2.6e-15 56.2 0.2 7.6e-14 51.5 0.0 2.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_24 PF13412.6 EEA24434.1 - 0.036 13.6 0.0 0.086 12.4 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 EEA24434.1 - 0.056 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Med9 PF07544.13 EEA24434.1 - 0.073 13.2 0.8 0.26 11.4 0.8 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DNA_repr_REX1B PF14966.6 EEA24434.1 - 0.08 13.6 0.9 0.28 11.9 0.1 2.2 2 0 0 2 2 2 0 DNA repair REX1-B LexA_DNA_bind PF01726.16 EEA24434.1 - 0.093 12.5 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 LexA DNA binding domain XPG_N PF00752.17 EEA24434.1 - 0.12 12.8 0.2 3.7 8.1 0.0 2.7 1 1 0 2 2 2 0 XPG N-terminal domain Fungal_trans PF04082.18 EEA24435.1 - 5.4e-24 84.7 3.3 8.7e-24 84.0 3.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24435.1 - 7.3e-07 29.2 11.9 1.8e-06 28.0 11.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.12 EEA24436.1 - 2.2e-25 88.7 2.8 4.6e-25 87.6 2.8 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA24436.1 - 1.5e-15 57.3 0.1 2.4e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA24436.1 - 0.00061 19.2 0.1 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 EEA24436.1 - 0.0043 16.6 0.3 0.0073 15.8 0.3 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus NAD_binding_10 PF13460.6 EEA24436.1 - 0.0059 16.5 0.1 0.009 15.9 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 EEA24436.1 - 0.0063 16.8 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 EEA24436.1 - 0.021 14.1 0.2 0.032 13.5 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 EEA24436.1 - 0.032 14.0 0.2 0.054 13.2 0.2 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ADH_zinc_N_2 PF13602.6 EEA24436.1 - 0.033 15.3 0.0 0.083 13.9 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase MFS_1 PF07690.16 EEA24437.1 - 8.6e-29 100.6 52.9 3.2e-27 95.4 52.9 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily NADH_dh_m_C1 PF15088.6 EEA24437.1 - 2.4 7.8 6.8 0.87 9.2 0.8 2.9 2 1 0 2 2 2 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Zn_clus PF00172.18 EEA24438.1 - 3.1e-10 40.0 10.4 6.8e-10 38.9 10.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA24438.1 - 0.01 14.9 0.5 0.018 14.1 0.5 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Pkinase PF00069.25 EEA24439.1 - 1.3e-54 185.4 0.0 1.7e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24439.1 - 3.3e-34 118.3 0.0 4.6e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA24439.1 - 3.6e-12 46.2 0.0 2.9e-08 33.4 0.0 2.2 1 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 EEA24439.1 - 0.007 15.7 0.0 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Sad1_UNC PF07738.13 EEA24440.1 - 7.8e-32 110.1 0.0 1.3e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal KRAP_IP3R_bind PF14722.6 EEA24440.1 - 0.014 15.2 0.0 0.045 13.5 0.0 1.9 1 0 0 1 1 1 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain Muskelin_N PF06588.11 EEA24440.1 - 0.065 13.1 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Muskelin N-terminus Spo12 PF05032.12 EEA24441.1 - 1.7e-16 59.8 1.2 4.4e-16 58.5 1.2 1.8 1 0 0 1 1 1 1 Spo12 family Spo12 PF05032.12 EEA24442.1 - 1.7e-16 59.8 1.2 4.4e-16 58.5 1.2 1.8 1 0 0 1 1 1 1 Spo12 family Acyl-CoA_dh_1 PF00441.24 EEA24443.1 - 8.4e-32 110.4 1.4 1.5e-31 109.6 1.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EEA24443.1 - 2e-20 72.8 0.0 3.4e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EEA24443.1 - 1.3e-14 54.8 0.1 2.6e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EEA24443.1 - 4.5e-13 49.6 3.0 1e-12 48.5 3.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EEA24444.1 - 9e-45 152.5 0.0 1.5e-42 145.3 0.0 2.3 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EEA24444.1 - 2.4e-31 107.8 0.0 4.3e-31 107.0 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EEA24444.1 - 7.2e-21 74.6 0.0 9.4e-17 61.4 0.0 3.5 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Sacchrp_dh_NADP PF03435.18 EEA24444.1 - 0.019 15.2 0.0 0.24 11.7 0.0 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 EEA24444.1 - 0.036 13.3 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 EEA24444.1 - 0.077 13.2 0.0 1.4 9.0 0.0 2.7 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EEA24444.1 - 0.092 12.6 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EEA24444.1 - 0.14 12.4 0.0 0.98 9.7 0.0 2.4 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA24444.1 - 0.15 11.6 0.2 0.42 10.1 0.2 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase DUF2278 PF10042.9 EEA24444.1 - 0.17 11.9 0.0 0.27 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) Glycos_transf_1 PF00534.20 EEA24445.1 - 9.6e-33 113.1 0.0 1.8e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA24445.1 - 7.1e-28 97.7 0.0 1.6e-27 96.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EEA24445.1 - 1.8e-17 64.2 0.4 1e-16 61.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EEA24445.1 - 6e-14 52.4 0.0 5.3e-13 49.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EEA24445.1 - 6.4e-08 32.9 0.0 1.5e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 MMR_HSR1 PF01926.23 EEA24446.1 - 5.5e-16 58.7 0.2 1e-13 51.4 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA24446.1 - 7.9e-07 28.7 0.2 0.00012 21.6 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EEA24446.1 - 3.7e-05 23.7 0.0 0.012 15.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EEA24446.1 - 0.016 14.5 0.0 0.036 13.4 0.0 1.6 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 EEA24446.1 - 0.21 11.6 12.5 0.27 11.3 0.2 3.5 4 1 1 5 5 5 0 Dynamin family LTV PF04180.14 EEA24447.1 - 3.6e-127 425.3 10.5 4.1e-127 425.1 10.5 1.0 1 0 0 1 1 1 1 Low temperature viability protein MAGE_N PF12440.8 EEA24447.1 - 2.4 8.9 6.2 41 4.9 0.1 3.2 2 1 0 2 2 2 0 Melanoma associated antigen family N terminal PLDc_2 PF13091.6 EEA24448.1 - 2.7e-16 59.7 0.0 9.1e-09 35.3 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EEA24448.1 - 2.3e-09 37.0 0.4 0.00029 20.9 0.1 2.9 2 1 0 2 2 2 2 Phospholipase D Active site motif NDUFA12 PF05071.16 EEA24449.1 - 2.1e-32 111.8 0.9 2.5e-32 111.6 0.9 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 TPR_14 PF13428.6 EEA24450.1 - 4.8e-11 42.5 12.7 2.4 9.2 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 EEA24450.1 - 3e-05 23.8 2.6 8.1 6.8 0.1 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA24450.1 - 0.00033 20.6 7.5 5 7.6 0.2 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA24450.1 - 0.00034 20.3 0.8 0.19 11.6 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA24450.1 - 0.013 15.4 2.7 14 6.0 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2076 PF09849.9 EEA24450.1 - 0.016 15.2 2.4 0.047 13.7 2.4 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CHIP_TPR_N PF18391.1 EEA24450.1 - 0.025 15.3 0.3 0.12 13.2 0.3 2.3 1 0 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain TPR_17 PF13431.6 EEA24450.1 - 0.051 14.0 1.9 50 4.6 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EEA24450.1 - 0.064 13.8 11.0 0.97 10.0 0.1 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF1840 PF08895.11 EEA24450.1 - 0.28 11.6 4.6 16 5.9 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1840) TPR_12 PF13424.6 EEA24450.1 - 0.42 10.9 10.2 16 5.9 0.5 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24450.1 - 1.3 9.7 8.3 16 6.3 0.1 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat RIX1 PF08167.12 EEA24451.1 - 6.3e-62 208.7 3.5 6.3e-62 208.7 3.5 1.9 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis NPR2 PF06218.11 EEA24451.1 - 0.15 10.8 0.1 0.23 10.1 0.1 1.2 1 0 0 1 1 1 0 Nitrogen permease regulator 2 MBOAT_2 PF13813.6 EEA24452.1 - 3.6e-23 81.6 2.1 1e-22 80.2 2.1 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family SNF2_N PF00176.23 EEA24453.1 - 2.2e-66 224.0 0.0 3.3e-66 223.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EEA24453.1 - 1.9e-20 72.6 0.0 4.2e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EEA24453.1 - 1.1e-16 61.1 0.0 2.4e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EEA24453.1 - 6.7e-10 38.6 6.9 1.5e-09 37.5 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA24453.1 - 5.3e-09 36.3 6.3 5.3e-09 36.3 6.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EEA24453.1 - 1.4e-07 31.3 6.9 3.5e-07 30.0 6.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA24453.1 - 1.9e-07 30.9 4.8 1.9e-07 30.9 4.8 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA24453.1 - 1.9e-07 31.2 3.6 5.1e-07 29.9 3.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EEA24453.1 - 1.1e-06 28.5 2.9 2.6e-06 27.3 2.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 EEA24453.1 - 1.1e-05 25.1 4.6 2.9e-05 23.8 4.0 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 EEA24453.1 - 3.6e-05 23.6 5.0 8.5e-05 22.4 5.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EEA24453.1 - 5.2e-05 23.3 5.6 0.0001 22.4 5.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EEA24453.1 - 0.00039 20.2 4.6 0.00039 20.2 4.6 1.7 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EEA24453.1 - 0.0011 18.7 1.9 0.0038 17.0 1.9 2.0 1 0 0 1 1 1 1 RING-like zinc finger U-box PF04564.15 EEA24453.1 - 0.012 15.8 0.0 0.032 14.4 0.0 1.7 1 0 0 1 1 1 0 U-box domain zf-ANAPC11 PF12861.7 EEA24453.1 - 0.012 15.6 0.9 0.029 14.4 0.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger HDA2-3 PF11496.8 EEA24453.1 - 0.077 12.2 0.0 0.27 10.4 0.0 1.9 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 zf-RING_4 PF14570.6 EEA24453.1 - 1.5 8.7 3.6 3.4 7.5 3.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain MMR_HSR1_Xtn PF16897.5 EEA24454.1 - 5.8e-34 116.3 1.3 1.1e-33 115.4 0.6 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EEA24454.1 - 5e-21 74.9 0.0 1.1e-20 73.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EEA24454.1 - 7.7e-19 67.5 0.1 1.6e-18 66.4 0.1 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EEA24454.1 - 5.7e-13 48.7 0.0 9.9e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA24454.1 - 3e-05 24.2 0.2 0.044 13.8 0.0 2.4 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 EEA24454.1 - 0.063 12.6 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 AIG1 family MeaB PF03308.16 EEA24454.1 - 0.068 12.1 0.3 0.15 11.1 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MCM PF00493.23 EEA24454.1 - 0.11 11.6 0.0 0.26 10.3 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain Torus PF16131.5 EEA24455.1 - 1.9e-46 157.2 1.8 6.7e-46 155.5 0.1 2.4 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 EEA24455.1 - 2.5e-09 36.8 0.0 5.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EEA24455.1 - 0.00014 21.8 0.4 0.00014 21.8 0.4 1.7 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 EEA24455.1 - 0.011 15.6 0.8 0.02 14.8 0.8 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nup35_RRM_2 PF14605.6 EEA24455.1 - 0.028 14.4 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Alpha_Helical PF18489.1 EEA24455.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Alpha helical domain zf-CCCH_4 PF18044.1 EEA24455.1 - 0.6 10.0 2.0 1.2 9.1 2.0 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger HGTP_anticodon2 PF12745.7 EEA24456.1 - 8.3e-86 287.7 2.4 3.7e-85 285.6 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EEA24456.1 - 3.2e-77 259.5 0.0 4.6e-37 127.8 0.0 3.9 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24456.1 - 9e-40 136.6 0.0 3.7e-17 62.5 0.0 3.6 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 EEA24456.1 - 9.1e-18 64.6 0.1 2.9e-17 63.0 0.1 1.9 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.6 EEA24456.1 - 1.7e-12 47.3 0.1 3.6e-11 42.9 0.0 2.3 2 0 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.23 EEA24456.1 - 4.6e-08 33.3 3.8 4.3e-06 26.8 0.0 3.4 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EEA24456.1 - 0.0059 16.0 0.0 0.63 9.3 0.0 2.7 2 0 0 2 2 2 1 Kinase-like HGTP_anticodon PF03129.20 EEA24456.1 - 0.0072 16.5 0.0 0.0072 16.5 0.0 1.9 2 0 0 2 2 1 1 Anticodon binding domain FTA2 PF13095.6 EEA24456.1 - 0.024 14.3 0.1 0.59 9.7 0.0 3.2 4 0 0 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 HIF-1a_CTAD PF08778.10 EEA24456.1 - 0.077 12.6 0.1 0.2 11.3 0.1 1.7 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain DUF1682 PF07946.14 EEA24456.1 - 3.2 6.9 10.8 5.4 6.1 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) OmpH PF03938.14 EEA24456.1 - 7.8 6.8 15.1 19 5.6 15.1 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Cut12 PF11500.8 EEA24457.1 - 2.6e-44 150.7 16.3 2.6e-44 150.7 16.3 2.9 2 1 0 2 2 2 1 Spindle pole body formation-associated protein Lebercilin PF15619.6 EEA24457.1 - 0.058 13.1 37.5 0.64 9.6 12.9 3.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Peptidase_S49 PF01343.18 EEA24457.1 - 0.4 10.6 2.9 16 5.4 0.1 2.5 2 0 0 2 2 2 0 Peptidase family S49 SpecificRecomb PF10136.9 EEA24457.1 - 2.9 6.1 6.8 2.4 6.3 5.5 1.4 1 1 0 1 1 1 0 Site-specific recombinase DUF89 PF01937.19 EEA24458.1 - 1.1e-134 448.9 0.0 1.2e-134 448.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Cytochrom_C550 PF14495.6 EEA24458.1 - 0.14 11.8 0.0 0.43 10.3 0.0 1.8 1 0 0 1 1 1 0 Cytochrome c-550 domain Metallophos PF00149.28 EEA24459.1 - 7.3e-33 114.8 0.1 1.1e-32 114.2 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EEA24459.1 - 9e-33 112.4 0.6 2e-32 111.4 0.6 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 EEA24459.1 - 4.3e-14 51.6 1.4 5.4e-05 22.8 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA24459.1 - 6.5e-10 38.4 2.8 0.0022 18.0 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EEA24459.1 - 2.2e-06 27.2 3.1 0.022 14.4 0.6 3.1 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.6 EEA24459.1 - 9.6e-06 26.0 0.4 0.056 13.9 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24459.1 - 1.8e-05 25.3 3.8 0.16 12.7 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EEA24459.1 - 0.00053 20.1 0.1 0.0059 16.7 0.0 2.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA24459.1 - 0.0012 19.3 0.6 0.57 10.9 0.0 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA24459.1 - 0.013 15.7 0.9 0.67 10.3 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24459.1 - 0.017 15.9 2.4 1.7 9.7 0.1 4.1 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 EEA24459.1 - 0.019 14.2 0.4 0.62 9.2 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Vps4_C PF09336.10 EEA24459.1 - 0.034 14.1 0.1 4.3 7.4 0.0 2.6 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain TPR_17 PF13431.6 EEA24459.1 - 0.038 14.4 0.8 1.2 9.7 0.1 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24459.1 - 0.12 12.7 0.7 0.98 9.8 0.2 2.4 2 1 1 3 3 2 0 Tetratricopeptide repeat MIT PF04212.18 EEA24459.1 - 0.13 12.3 0.1 22 5.2 0.0 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Kelch_4 PF13418.6 EEA24459.1 - 0.16 12.0 0.6 0.71 9.9 0.1 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Spt4 PF06093.13 EEA24460.1 - 1e-32 112.1 0.2 1.2e-32 111.8 0.2 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger TackOD1 PF18551.1 EEA24460.1 - 0.043 13.5 1.0 0.059 13.0 1.0 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Zn_ribbon_17 PF17120.5 EEA24460.1 - 0.23 11.1 2.9 0.46 10.2 2.9 1.5 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Aminotran_3 PF00202.21 EEA24461.1 - 1.3e-123 412.7 0.0 1.4e-123 412.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EEA24461.1 - 0.067 12.3 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Aminotran_3 PF00202.21 EEA24462.1 - 1.3e-123 412.7 0.0 1.4e-123 412.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EEA24462.1 - 0.067 12.3 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II OppC_N PF12911.7 EEA24463.1 - 0.13 12.2 1.4 7.9 6.6 0.0 2.9 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MFS_MOT1 PF16983.5 EEA24463.1 - 4.9 7.6 8.3 2.5 8.5 0.5 2.8 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily Bestrophin PF01062.21 EEA24464.1 - 2.7e-36 125.5 0.0 5e-36 124.6 0.0 1.4 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel T6SS_VasE PF05936.12 EEA24464.1 - 0.015 14.0 0.0 0.023 13.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE DUF1153 PF06627.11 EEA24464.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) Sugar_tr PF00083.24 EEA24466.1 - 1.4e-90 304.3 22.1 1.9e-90 303.9 22.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24466.1 - 5.9e-11 41.9 46.7 1.2e-09 37.6 35.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GSH_synth_ATP PF03917.17 EEA24467.1 - 5.1e-75 252.6 0.0 6.3e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EEA24467.1 - 4.5e-29 100.9 0.0 1.3e-28 99.4 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic glutathione synthase SNF2_N PF00176.23 EEA24468.1 - 5.7e-46 156.8 0.8 1.1e-45 156.0 0.1 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA24468.1 - 1.1e-20 74.1 0.0 3.7e-20 72.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA24468.1 - 5e-06 26.6 0.0 1.4e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA24468.1 - 0.00029 20.1 0.1 0.00068 18.9 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EEA24468.1 - 0.00034 20.4 0.0 0.082 12.6 0.0 2.6 2 0 0 2 2 2 2 SWI2/SNF2 ATPase DUF4041 PF13250.6 EEA24468.1 - 0.025 14.5 0.3 0.07 13.0 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) Arch_fla_DE PF04659.13 EEA24468.1 - 0.097 12.5 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Archaeal flagella protein PIG-X PF08320.12 EEA24469.1 - 8.6e-71 238.2 0.0 1.9e-70 237.1 0.0 1.6 2 0 0 2 2 2 1 PIG-X / PBN1 GATase PF00117.28 EEA24470.1 - 7.2e-47 159.6 0.0 9.7e-47 159.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EEA24470.1 - 1.5e-45 154.2 0.0 3.4e-45 153.0 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 EEA24470.1 - 0.00031 20.6 0.5 0.004 16.9 0.5 2.3 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 EEA24470.1 - 0.004 17.0 0.0 0.0088 15.9 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family DnaJ_C PF01556.18 EEA24471.1 - 3.6e-37 127.7 1.6 4.7e-37 127.3 1.6 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA24471.1 - 1e-27 96.0 6.2 1.6e-27 95.4 6.2 1.3 1 0 0 1 1 1 1 DnaJ domain Malate_DH PF12434.8 EEA24471.1 - 0.1 12.6 0.3 0.25 11.4 0.3 1.6 1 0 0 1 1 1 0 Malate dehydrogenase enzyme Chorion_3 PF05387.11 EEA24471.1 - 0.19 11.3 1.2 0.42 10.2 1.2 1.5 1 0 0 1 1 1 0 Chorion family 3 ETF PF01012.21 EEA24472.1 - 7.2e-43 146.6 0.4 8.5e-43 146.3 0.4 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Ribosomal_L20 PF00453.18 EEA24472.1 - 0.17 12.0 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L20 Ysc84 PF04366.12 EEA24473.1 - 1.6e-46 157.2 0.1 3.4e-46 156.1 0.0 1.6 2 0 0 2 2 2 1 Las17-binding protein actin regulator PARP PF00644.20 EEA24474.1 - 2e-55 187.4 3.6 2.8e-55 186.9 0.0 2.7 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EEA24474.1 - 1.6e-41 141.6 0.7 2.9e-41 140.8 0.7 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EEA24474.1 - 2.2e-20 72.5 0.6 6e-20 71.1 0.6 1.8 1 0 0 1 1 1 1 WGR domain BRCT PF00533.26 EEA24474.1 - 3.7e-11 43.3 0.0 8.3e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EEA24474.1 - 1.7e-06 27.8 0.0 3.8e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EEA24474.1 - 0.00021 21.6 0.0 0.00046 20.6 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Peptidase_S10 PF00450.22 EEA24475.1 - 1.8e-89 301.0 1.5 2.3e-89 300.7 1.5 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase MFS_1 PF07690.16 EEA24476.1 - 6.8e-31 107.5 29.5 6.8e-31 107.5 29.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF308 PF03729.13 EEA24476.1 - 0.24 11.8 0.2 0.24 11.8 0.2 4.7 3 1 0 4 4 4 0 Short repeat of unknown function (DUF308) OppC_N PF12911.7 EEA24476.1 - 0.58 10.2 0.0 0.58 10.2 0.0 3.0 2 1 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C RNA_pol_I_A49 PF06870.12 EEA24477.1 - 1.8e-74 251.0 0.1 2.3e-74 250.6 0.1 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Ribosomal_L27e PF01777.18 EEA24477.1 - 0.046 14.1 0.4 0.34 11.3 0.0 2.4 2 1 0 2 2 2 0 Ribosomal L27e protein family Peroxin-3 PF04882.12 EEA24478.1 - 4.1e-163 543.7 3.3 5.7e-163 543.3 3.3 1.2 1 0 0 1 1 1 1 Peroxin-3 ATG101 PF07855.12 EEA24479.1 - 6.3e-55 185.4 0.0 7.2e-55 185.2 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 SQHop_cyclase_C PF13243.6 EEA24479.1 - 0.14 11.3 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain TB2_DP1_HVA22 PF03134.19 EEA24480.1 - 1.6e-27 95.2 9.1 1.6e-27 95.2 9.1 1.7 1 1 1 2 2 2 2 TB2/DP1, HVA22 family RhodobacterPufX PF11511.8 EEA24480.1 - 4.5 6.9 5.6 2.4 7.8 2.0 2.2 2 0 0 2 2 2 0 Intrinsic membrane protein PufX TB2_DP1_HVA22 PF03134.19 EEA24481.1 - 1.6e-27 95.2 9.1 1.6e-27 95.2 9.1 1.7 1 1 1 2 2 2 2 TB2/DP1, HVA22 family RhodobacterPufX PF11511.8 EEA24481.1 - 4.5 6.9 5.6 2.4 7.8 2.0 2.2 2 0 0 2 2 2 0 Intrinsic membrane protein PufX Aminotran_1_2 PF00155.21 EEA24482.1 - 3.8e-86 289.5 0.0 5.2e-86 289.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA24482.1 - 3.3e-06 25.9 0.0 5.5e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EEA24482.1 - 1.3e-05 24.6 0.2 2.4e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EEA24482.1 - 6e-05 22.2 0.0 9.6e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF3405 PF11885.8 EEA24482.1 - 0.33 9.5 1.6 0.4 9.2 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) DUF2471 PF10616.9 EEA24485.1 - 0.045 14.3 0.0 0.063 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2471) Na_H_Exchanger PF00999.21 EEA24486.1 - 1.1e-68 231.8 35.2 1.4e-68 231.4 35.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SNF2_N PF00176.23 EEA24486.1 - 1.1e-64 218.4 1.3 2.2e-64 217.4 1.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 EEA24486.1 - 1.1e-48 165.0 23.0 1.1e-48 165.0 23.0 4.6 3 1 1 4 4 4 1 DNA-binding domain Helicase_C PF00271.31 EEA24486.1 - 3.4e-19 69.2 0.0 8e-19 68.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA24486.1 - 2e-07 31.2 1.4 2.9e-06 27.4 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA24486.1 - 0.0043 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EEA24486.1 - 0.013 14.7 0.0 0.071 12.3 0.0 2.2 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 PepSY_TM PF03929.16 EEA24486.1 - 0.75 9.4 2.8 1.4 8.6 0.2 2.8 2 0 0 2 2 2 0 PepSY-associated TM region DUF4192 PF13830.6 EEA24487.1 - 1.5 8.9 3.4 0.79 9.7 0.6 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4192) MFS_2 PF13347.6 EEA24488.1 - 1.2e-10 40.5 10.0 3e-10 39.2 4.7 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein PUCC PF03209.15 EEA24488.1 - 0.0014 17.7 1.8 0.0033 16.5 1.8 1.5 1 0 0 1 1 1 1 PUCC protein MARCKS PF02063.17 EEA24488.1 - 0.072 13.1 1.4 0.085 12.8 0.0 1.7 2 0 0 2 2 2 0 MARCKS family Phosphonate-bd PF12974.7 EEA24488.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein STE PF02200.16 EEA24489.1 - 1.6e-56 189.5 0.1 2.7e-56 188.7 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EEA24489.1 - 1.8e-11 43.8 10.7 5e-07 29.8 0.9 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA24489.1 - 6.1e-09 35.9 4.1 6.1e-09 35.9 4.1 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA24489.1 - 2.7e-08 34.0 8.5 0.0002 21.9 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EEA24489.1 - 8e-05 22.5 0.2 8e-05 22.5 0.2 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA24489.1 - 0.0026 18.0 0.2 0.041 14.2 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding NOA36 PF06524.12 EEA24489.1 - 0.059 12.7 1.1 0.1 11.9 1.1 1.3 1 0 0 1 1 1 0 NOA36 protein zinc_ribbon_9 PF14369.6 EEA24489.1 - 0.09 13.1 0.2 0.22 11.8 0.2 1.6 1 0 0 1 1 1 0 zinc-ribbon FYDLN_acid PF09538.10 EEA24489.1 - 0.12 13.0 0.2 0.38 11.4 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf-C2H2_2 PF12756.7 EEA24489.1 - 0.15 12.4 1.0 0.43 10.9 1.0 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-TRAF PF02176.18 EEA24489.1 - 0.17 12.6 2.6 0.29 11.9 2.6 1.3 1 0 0 1 1 1 0 TRAF-type zinc finger zf-Di19 PF05605.12 EEA24489.1 - 0.48 10.8 4.3 0.2 12.0 0.4 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding FOXP-CC PF16159.5 EEA24489.1 - 1.4 9.6 3.8 19 5.9 0.2 2.7 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2HC_2 PF13913.6 EEA24489.1 - 2 8.4 5.3 2.3 8.2 0.3 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DUF5544 PF17698.1 EEA24489.1 - 6.2 7.0 6.6 9.4 6.4 0.2 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5544) DUF4602 PF15375.6 EEA24490.1 - 2.3e-11 44.1 19.1 8e-11 42.4 19.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) ECM1 PF05782.11 EEA24490.1 - 0.06 12.3 2.6 0.073 12.0 2.6 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) His_biosynth PF00977.21 EEA24491.1 - 2.9e-33 115.2 0.0 3.8e-33 114.9 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein SecE PF00584.20 EEA24493.1 - 1.3 9.0 5.3 6.7 6.7 0.9 2.1 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex Radical_SAM_C PF16199.5 EEA24494.1 - 2.3e-32 110.8 0.0 4.9e-32 109.8 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EEA24494.1 - 2.3e-20 73.6 0.1 9.5e-20 71.6 0.0 2.0 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EEA24494.1 - 1.2e-10 41.6 0.1 2.4e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA24494.1 - 3.4e-06 27.0 0.1 1.2e-05 25.2 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA24494.1 - 0.12 12.8 0.2 0.29 11.6 0.2 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AP_endonuc_2 PF01261.24 EEA24494.1 - 0.17 11.3 0.0 0.36 10.2 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel CoA_binding PF02629.19 EEA24495.1 - 1.7e-27 95.9 3.6 2e-27 95.7 0.9 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EEA24495.1 - 1.2e-22 80.4 0.2 1.9e-22 79.7 0.2 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EEA24495.1 - 2.5e-08 33.8 0.0 4.6e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EEA24495.1 - 0.00095 19.6 0.1 0.0022 18.4 0.1 1.7 1 0 0 1 1 1 1 CoA binding domain RFX_DNA_binding PF02257.15 EEA24496.1 - 4.9e-28 97.6 0.2 1e-27 96.6 0.2 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain ThiF PF00899.21 EEA24498.1 - 8.8e-30 103.8 0.0 1.3e-29 103.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family Swi5 PF07061.11 EEA24499.1 - 2.9e-30 104.2 0.0 4.5e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Swi5 Prefoldin_2 PF01920.20 EEA24499.1 - 0.00062 19.7 0.4 0.0011 18.8 0.4 1.4 1 0 0 1 1 1 1 Prefoldin subunit FlxA PF14282.6 EEA24499.1 - 0.0087 16.0 6.4 0.011 15.7 6.4 1.2 1 0 0 1 1 1 1 FlxA-like protein Tropomyosin_1 PF12718.7 EEA24499.1 - 0.019 15.1 0.5 0.022 14.9 0.5 1.1 1 0 0 1 1 1 0 Tropomyosin like ADIP PF11559.8 EEA24499.1 - 0.024 14.7 0.7 0.029 14.5 0.7 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4472 PF14739.6 EEA24499.1 - 0.031 15.0 0.1 0.04 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) CLZ PF16526.5 EEA24499.1 - 0.034 14.5 0.3 0.059 13.7 0.3 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels LZ3wCH PF18517.1 EEA24499.1 - 0.041 14.0 0.0 0.1 12.7 0.0 1.7 2 0 0 2 2 2 0 Leucine zipper with capping helix domain Not3 PF04065.15 EEA24499.1 - 0.054 12.9 2.1 0.097 12.1 2.0 1.5 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component MscS_porin PF12795.7 EEA24499.1 - 0.058 12.9 6.5 0.067 12.7 6.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF4200 PF13863.6 EEA24499.1 - 0.08 13.3 0.6 0.14 12.6 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Swi5 PF07061.11 EEA24500.1 - 6.6e-32 109.4 0.1 1e-31 108.8 0.1 1.3 1 0 0 1 1 1 1 Swi5 Prefoldin_2 PF01920.20 EEA24500.1 - 0.0024 17.8 0.6 0.004 17.1 0.6 1.4 1 0 0 1 1 1 1 Prefoldin subunit HsbA PF12296.8 EEA24500.1 - 0.0058 17.0 0.1 0.008 16.6 0.1 1.2 1 0 0 1 1 1 1 Hydrophobic surface binding protein A DUF4472 PF14739.6 EEA24500.1 - 0.0074 17.0 0.4 0.01 16.5 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4472) CCDC-167 PF15188.6 EEA24500.1 - 0.015 15.6 0.1 0.023 15.0 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 COG6 PF06419.11 EEA24500.1 - 0.019 13.2 0.2 0.019 13.2 0.2 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 FlxA PF14282.6 EEA24500.1 - 0.019 15.0 8.5 0.025 14.5 8.5 1.2 1 0 0 1 1 1 0 FlxA-like protein Tropomyosin_1 PF12718.7 EEA24500.1 - 0.02 15.0 0.9 0.025 14.7 0.9 1.1 1 0 0 1 1 1 0 Tropomyosin like CLZ PF16526.5 EEA24500.1 - 0.032 14.6 0.4 0.055 13.8 0.4 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Not3 PF04065.15 EEA24500.1 - 0.034 13.6 2.1 0.079 12.4 2.3 1.4 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component LZ3wCH PF18517.1 EEA24500.1 - 0.039 14.1 0.0 0.093 12.8 0.0 1.7 2 0 0 2 2 2 0 Leucine zipper with capping helix domain SF1-HH PF16275.5 EEA24500.1 - 0.049 14.0 0.8 0.049 14.0 0.8 1.5 2 0 0 2 2 2 0 Splicing factor 1 helix-hairpin domain CCM2_C PF16545.5 EEA24500.1 - 0.063 13.8 0.1 0.12 12.9 0.1 1.7 1 1 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology SlyX PF04102.12 EEA24500.1 - 0.082 13.5 1.5 0.12 13.0 1.0 1.5 1 1 0 1 1 1 0 SlyX DUF4200 PF13863.6 EEA24500.1 - 0.092 13.1 1.4 0.096 13.1 1.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Ytp1 PF10355.9 EEA24501.1 - 3.5e-73 246.2 24.2 1.3e-72 244.4 16.9 2.8 2 1 0 2 2 2 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EEA24501.1 - 1.6e-32 111.4 5.0 1.6e-32 111.4 5.0 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) DUF3180 PF11377.8 EEA24501.1 - 0.0017 18.5 8.2 0.083 13.0 6.1 2.9 2 2 0 2 2 2 1 Protein of unknown function (DUF3180) ExoD PF06055.12 EEA24501.1 - 0.24 10.8 6.6 0.029 13.7 1.6 2.2 2 0 0 2 2 2 0 Exopolysaccharide synthesis, ExoD Ytp1 PF10355.9 EEA24502.1 - 3.8e-73 246.1 24.4 1.4e-72 244.2 17.1 2.8 2 1 0 2 2 2 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EEA24502.1 - 1.5e-32 111.5 5.0 1.5e-32 111.5 5.0 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) DUF3180 PF11377.8 EEA24502.1 - 0.0016 18.6 8.1 0.079 13.1 6.1 2.9 2 2 0 2 2 2 1 Protein of unknown function (DUF3180) ExoD PF06055.12 EEA24502.1 - 0.23 10.8 6.6 0.029 13.8 1.6 2.2 2 0 0 2 2 2 0 Exopolysaccharide synthesis, ExoD ABC_membrane PF00664.23 EEA24503.1 - 1.4e-106 356.2 37.1 1.8e-56 191.8 16.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA24503.1 - 1.1e-70 236.5 0.0 2.2e-34 118.9 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EEA24503.1 - 6.8e-14 51.8 0.0 7.5e-05 22.3 0.6 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA24503.1 - 1.4e-09 38.6 2.4 0.0005 20.5 0.1 3.6 2 2 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA24503.1 - 5.6e-07 29.6 0.0 0.032 14.1 0.0 3.5 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EEA24503.1 - 6e-07 29.1 1.2 0.0024 17.5 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EEA24503.1 - 2e-06 26.9 1.7 0.0059 15.5 0.0 2.8 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA PF00004.29 EEA24503.1 - 3.4e-05 24.3 0.6 4.5 7.7 0.0 4.5 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA24503.1 - 4.3e-05 23.8 0.0 0.7 10.2 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_25 PF13481.6 EEA24503.1 - 0.00011 21.8 1.0 0.12 12.0 0.1 3.4 3 1 0 3 3 3 1 AAA domain AAA_21 PF13304.6 EEA24503.1 - 0.00043 20.2 0.8 0.58 9.9 0.0 3.2 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EEA24503.1 - 0.00072 19.4 2.0 0.54 9.9 0.0 2.6 3 0 0 3 3 3 2 AAA ATPase domain AAA_7 PF12775.7 EEA24503.1 - 0.0014 18.2 0.1 1.5 8.3 0.0 2.7 3 0 0 3 3 2 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 EEA24503.1 - 0.0015 17.8 0.2 2.4 7.4 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin G-alpha PF00503.20 EEA24503.1 - 0.002 17.4 0.1 1.5 7.9 0.0 2.4 2 0 0 2 2 2 2 G-protein alpha subunit AAA_30 PF13604.6 EEA24503.1 - 0.0034 17.1 7.8 0.56 9.9 0.0 4.1 4 1 0 4 4 4 2 AAA domain AAA_5 PF07728.14 EEA24503.1 - 0.005 16.8 0.1 3.9 7.5 0.0 3.0 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EEA24503.1 - 0.0061 17.1 0.2 7.8 7.1 0.1 2.9 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EEA24503.1 - 0.0082 16.3 0.0 5.8 7.1 0.0 3.0 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 EEA24503.1 - 0.0097 15.8 0.0 0.82 9.6 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain SbcCD_C PF13558.6 EEA24503.1 - 0.011 16.0 4.6 1.9 8.8 0.4 4.1 3 2 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.6 EEA24503.1 - 0.014 15.7 0.3 0.59 10.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EEA24503.1 - 0.02 14.5 0.1 4.7 6.8 0.0 2.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain APS_kinase PF01583.20 EEA24503.1 - 0.021 14.7 0.0 1.4 8.7 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF2207 PF09972.9 EEA24503.1 - 0.026 13.3 0.0 0.026 13.3 0.0 3.7 3 2 0 3 3 3 0 Predicted membrane protein (DUF2207) Mg_chelatase PF01078.21 EEA24503.1 - 0.031 13.7 0.0 2.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF4355 PF14265.6 EEA24503.1 - 0.066 13.4 0.4 0.25 11.6 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) AAA_24 PF13479.6 EEA24503.1 - 0.067 12.9 0.2 14 5.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EEA24503.1 - 0.071 13.5 0.0 13 6.3 0.0 3.1 3 0 0 3 3 2 0 RNA helicase PRK PF00485.18 EEA24503.1 - 0.14 11.9 0.0 6.4 6.5 0.0 2.7 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family MMR_HSR1 PF01926.23 EEA24503.1 - 0.22 11.6 1.4 20 5.3 0.0 3.1 3 0 0 3 3 2 0 50S ribosome-binding GTPase DUF87 PF01935.17 EEA24503.1 - 0.53 10.3 3.2 9 6.3 0.0 3.0 3 0 0 3 3 2 0 Helicase HerA, central domain DUF2518 PF10726.9 EEA24503.1 - 0.74 9.5 5.7 0.11 12.2 0.5 2.3 2 0 0 2 2 1 0 Protein of function (DUF2518) Usp PF00582.26 EEA24503.1 - 1.8 9.0 4.2 7 7.2 0.2 3.0 3 0 0 3 3 2 0 Universal stress protein family AAA_23 PF13476.6 EEA24503.1 - 2 8.9 10.9 0.87 10.0 0.5 3.6 4 0 0 4 4 4 0 AAA domain Skp1 PF01466.19 EEA24504.1 - 2.6e-28 97.9 0.5 4.6e-28 97.1 0.5 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EEA24504.1 - 2.4e-23 82.1 0.3 5.7e-23 80.9 0.2 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 EEA24504.1 - 0.079 13.2 0.0 1.1 9.5 0.0 2.1 1 1 0 1 1 1 0 BTB/POZ domain Skp1 PF01466.19 EEA24505.1 - 2.6e-28 97.9 0.5 4.6e-28 97.1 0.5 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EEA24505.1 - 2.4e-23 82.1 0.3 5.7e-23 80.9 0.2 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 EEA24505.1 - 0.079 13.2 0.0 1.1 9.5 0.0 2.1 1 1 0 1 1 1 0 BTB/POZ domain Glyco_transf_22 PF03901.17 EEA24506.1 - 4.7e-68 230.3 23.0 6.3e-68 229.9 23.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family XPC-binding PF09280.11 EEA24508.1 - 5.8e-24 83.6 18.0 9.5e-24 82.9 18.0 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.31 EEA24508.1 - 1.4e-23 82.4 1.3 2.1e-12 46.7 0.1 2.5 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 EEA24508.1 - 2.8e-23 81.4 0.1 4.7e-23 80.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EEA24508.1 - 3.7e-08 33.1 0.2 6e-08 32.4 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EEA24508.1 - 0.0013 19.0 0.2 0.0025 18.1 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA24508.1 - 0.005 16.9 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EEA24508.1 - 0.035 13.9 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain Ubiquitin_2 PF14560.6 EEA24508.1 - 0.059 13.8 0.1 0.12 12.9 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 EEA24508.1 - 0.1 13.1 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Phasin_2 PF09361.10 EEA24508.1 - 2.3 8.5 6.3 1.4 9.2 0.9 2.4 1 1 1 2 2 2 0 Phasin protein Asp PF00026.23 EEA24509.1 - 9.5e-51 173.1 0.2 1.1e-50 172.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA24509.1 - 0.0047 17.2 0.2 0.61 10.3 0.0 2.6 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA24509.1 - 0.026 15.1 0.2 7.4 7.3 0.0 3.0 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 EEA24509.1 - 0.079 13.5 0.0 7.2 7.2 0.0 3.1 4 0 0 4 4 4 0 gag-polyprotein putative aspartyl protease Cys_Met_Meta_PP PF01053.20 EEA24512.1 - 8.5e-142 472.2 0.0 9.8e-142 472.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EEA24512.1 - 3.1e-06 26.6 0.0 4.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EEA24512.1 - 2.4e-05 23.5 0.0 4.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EEA24512.1 - 2.8e-05 23.6 0.1 8.2e-05 22.1 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.11 EEA24512.1 - 0.00013 20.6 0.0 0.00041 19.0 0.0 1.7 1 1 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.21 EEA24512.1 - 0.0084 15.4 0.0 0.032 13.5 0.0 1.8 2 0 0 2 2 2 1 Beta-eliminating lyase TQ PF18202.1 EEA24512.1 - 0.06 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 T-Q ester bond containing domain Fungal_trans PF04082.18 EEA24513.1 - 4.4e-35 121.0 0.0 1e-34 119.8 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24513.1 - 0.025 14.7 3.3 0.051 13.7 3.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA PF00004.29 EEA24515.1 - 1.5e-37 129.0 0.0 3.2e-37 127.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA24515.1 - 2.4e-09 36.8 0.1 5.2e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EEA24515.1 - 2.3e-05 24.9 0.2 0.0004 20.8 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EEA24515.1 - 2.7e-05 24.0 0.0 5.8e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EEA24515.1 - 3.4e-05 23.9 0.0 8.8e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EEA24515.1 - 3.6e-05 23.8 0.2 0.00047 20.2 0.2 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA24515.1 - 0.00023 21.3 0.0 0.00049 20.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA24515.1 - 0.00035 20.8 0.6 0.0038 17.5 0.1 2.5 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EEA24515.1 - 0.00042 20.9 0.0 0.0021 18.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA24515.1 - 0.00059 20.0 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EEA24515.1 - 0.00071 19.4 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EEA24515.1 - 0.00079 18.9 0.1 0.0019 17.7 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA24515.1 - 0.0014 19.0 0.0 0.0038 17.6 0.0 1.9 1 1 0 1 1 1 1 RNA helicase TniB PF05621.11 EEA24515.1 - 0.002 17.6 0.0 1.5 8.2 0.0 2.4 1 1 0 2 2 2 2 Bacterial TniB protein AAA_25 PF13481.6 EEA24515.1 - 0.0023 17.5 0.1 0.034 13.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 EEA24515.1 - 0.0048 16.0 0.0 0.0086 15.2 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 NACHT PF05729.12 EEA24515.1 - 0.0054 16.7 0.0 0.016 15.1 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 EEA24515.1 - 0.0073 16.0 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EEA24515.1 - 0.0084 16.4 0.0 0.021 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EEA24515.1 - 0.015 15.2 0.1 0.041 13.8 0.1 1.6 1 1 1 2 2 2 0 Rad17 P-loop domain Sigma54_activ_2 PF14532.6 EEA24515.1 - 0.017 15.2 0.0 0.039 14.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 EEA24515.1 - 0.025 15.1 0.0 0.073 13.6 0.0 1.9 1 1 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 EEA24515.1 - 0.026 14.2 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 EEA24515.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 EEA24515.1 - 0.064 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 EEA24515.1 - 0.067 13.1 0.0 0.25 11.2 0.0 1.8 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea CPT PF07931.12 EEA24515.1 - 0.069 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TsaE PF02367.17 EEA24515.1 - 0.089 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Guanylate_kin PF00625.21 EEA24515.1 - 0.12 12.0 0.0 1.7 8.3 0.0 2.7 2 1 0 2 2 2 0 Guanylate kinase TIP49 PF06068.13 EEA24515.1 - 0.13 11.5 0.1 0.38 9.9 0.0 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain Viral_helicase1 PF01443.18 EEA24515.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 EEA24515.1 - 0.16 11.3 0.0 0.78 9.0 0.0 2.0 1 1 1 2 2 2 0 KaiC AAA_21 PF13304.6 EEA24515.1 - 0.16 11.7 0.0 13 5.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Csm1 PF12539.8 EEA24516.1 - 8.6e-32 109.6 0.3 3.4e-31 107.7 0.1 2.0 2 0 0 2 2 1 1 Chromosome segregation protein Csm1/Pcs1 ADIP PF11559.8 EEA24516.1 - 0.00023 21.3 6.4 0.00061 19.9 6.4 1.8 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DHR10 PF18595.1 EEA24516.1 - 0.00067 19.7 12.5 0.0028 17.7 12.4 2.1 1 1 0 1 1 1 1 Designed helical repeat protein 10 domain EzrA PF06160.12 EEA24516.1 - 0.00069 17.9 4.1 0.001 17.3 4.1 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Filament PF00038.21 EEA24516.1 - 0.0038 16.8 9.7 0.011 15.3 9.7 1.8 1 1 0 1 1 1 1 Intermediate filament protein TMF_DNA_bd PF12329.8 EEA24516.1 - 0.0042 17.1 1.2 0.0042 17.1 1.2 3.1 3 0 0 3 3 3 1 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 EEA24516.1 - 0.0043 16.0 9.0 0.0043 16.0 9.0 1.6 2 0 0 2 2 1 1 Spc7 kinetochore protein PKcGMP_CC PF16808.5 EEA24516.1 - 0.0063 16.3 1.5 0.033 14.1 0.5 2.4 1 1 1 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Csm1_N PF18504.1 EEA24516.1 - 0.01 16.1 7.4 0.062 13.7 3.6 3.1 1 1 1 2 2 2 0 Csm1 N-terminal domain TMF_TATA_bd PF12325.8 EEA24516.1 - 0.015 15.5 2.9 0.015 15.5 2.9 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding APG6_N PF17675.1 EEA24516.1 - 0.017 15.7 8.7 0.017 15.7 8.7 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF445 PF04286.12 EEA24516.1 - 0.031 14.1 1.4 0.047 13.5 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF3138 PF11336.8 EEA24516.1 - 0.034 12.8 2.7 0.055 12.1 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Strabismus PF06638.11 EEA24516.1 - 0.048 12.3 0.2 0.091 11.4 0.2 1.4 1 0 0 1 1 1 0 Strabismus protein NPV_P10 PF05531.12 EEA24516.1 - 0.057 13.9 2.1 0.25 11.8 2.0 2.2 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein Poxvirus_B22R PF04395.12 EEA24516.1 - 0.08 12.5 12.6 2.3 7.7 12.6 2.2 1 1 0 1 1 1 0 Poxvirus B22R protein XhlA PF10779.9 EEA24516.1 - 0.084 13.1 1.0 0.27 11.5 1.0 1.9 1 0 0 1 1 1 0 Haemolysin XhlA CENP-K PF11802.8 EEA24516.1 - 0.1 12.1 3.7 0.16 11.5 3.7 1.2 1 0 0 1 1 1 0 Centromere-associated protein K HAUS-augmin3 PF14932.6 EEA24516.1 - 0.12 12.0 7.2 0.21 11.1 7.2 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 GAS PF13851.6 EEA24516.1 - 0.12 11.7 11.0 0.16 11.3 8.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding V_ATPase_I PF01496.19 EEA24516.1 - 0.13 10.1 2.7 0.23 9.3 2.7 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.8 EEA24516.1 - 0.17 11.2 10.8 0.27 10.5 9.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) GCN5L1 PF06320.13 EEA24516.1 - 0.24 11.6 4.1 0.69 10.1 3.8 2.0 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) NYD-SP28 PF14772.6 EEA24516.1 - 0.25 11.4 6.2 0.079 13.0 0.8 2.5 1 1 0 2 2 2 0 Sperm tail HAP1_N PF04849.13 EEA24516.1 - 0.26 10.5 10.2 1.2 8.2 8.1 2.0 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Holin_BhlA PF10960.8 EEA24516.1 - 0.31 11.1 1.1 9 6.3 0.0 3.1 3 0 0 3 3 3 0 BhlA holin family CREPT PF16566.5 EEA24516.1 - 0.34 11.1 6.4 0.75 10.0 6.4 1.6 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2203 PF09969.9 EEA24516.1 - 0.34 11.6 6.6 2.3 9.0 4.6 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) HIP1_clath_bdg PF16515.5 EEA24516.1 - 0.45 11.2 11.8 0.4 11.3 7.5 2.8 2 1 1 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 COG2 PF06148.11 EEA24516.1 - 0.47 10.5 6.3 2.1 8.4 0.2 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Bacillus_HBL PF05791.11 EEA24516.1 - 0.51 10.1 6.8 16 5.3 4.6 2.7 3 1 0 3 3 2 0 Bacillus haemolytic enterotoxin (HBL) DUF4446 PF14584.6 EEA24516.1 - 0.53 10.3 3.9 0.56 10.2 1.4 2.2 2 1 1 3 3 2 0 Protein of unknown function (DUF4446) Prominin PF05478.11 EEA24516.1 - 0.55 8.1 3.0 0.74 7.7 3.0 1.1 1 0 0 1 1 1 0 Prominin Mt_ATP-synt_D PF05873.12 EEA24516.1 - 0.56 10.1 2.6 0.69 9.8 0.7 2.0 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF641 PF04859.12 EEA24516.1 - 0.58 10.5 8.2 2.1 8.7 7.5 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Seryl_tRNA_N PF02403.22 EEA24516.1 - 0.59 10.4 7.9 2 8.7 7.9 2.0 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 EEA24516.1 - 0.6 10.2 3.1 1.3 9.1 3.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 EEA24516.1 - 0.73 9.9 11.6 0.37 10.9 7.3 2.3 2 1 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 EEA24516.1 - 0.88 8.6 7.9 1.8 7.6 7.9 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.10 EEA24516.1 - 0.95 9.6 7.2 0.84 9.8 2.7 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CLZ PF16526.5 EEA24516.1 - 1.1 9.6 7.8 0.97 9.8 4.5 2.6 2 0 0 2 2 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Bap31_Bap29_C PF18035.1 EEA24516.1 - 1.6 8.8 10.5 1.3e+02 2.7 0.0 4.1 3 1 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain PspA_IM30 PF04012.12 EEA24516.1 - 1.7 8.2 22.1 0.073 12.6 13.9 2.7 1 1 2 3 3 3 0 PspA/IM30 family Phage_GP20 PF06810.11 EEA24516.1 - 1.7 8.4 11.7 2.6 7.8 9.8 2.3 1 1 0 1 1 1 0 Phage minor structural protein GP20 YabA PF06156.13 EEA24516.1 - 1.9 9.2 8.3 4.8 7.9 2.2 3.0 1 1 2 3 3 3 0 Initiation control protein YabA Syntaxin-6_N PF09177.11 EEA24516.1 - 2.1 8.9 6.6 17 6.0 4.7 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 EEA24516.1 - 2.8 8.3 9.3 4.8 7.5 1.1 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF812 PF05667.11 EEA24516.1 - 3.3 6.5 19.7 48 2.6 19.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF812) IFT20 PF14931.6 EEA24516.1 - 3.7 7.8 10.8 3.5 7.8 8.5 2.1 2 1 1 3 3 1 0 Intraflagellar transport complex B, subunit 20 USP8_interact PF08941.10 EEA24516.1 - 4.3 7.1 6.0 1.5 8.6 1.5 2.1 1 1 1 2 2 2 0 USP8 interacting DUF724 PF05266.14 EEA24516.1 - 4.8 7.0 8.1 13 5.5 7.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Prefoldin_2 PF01920.20 EEA24516.1 - 5.1 7.1 12.2 0.46 10.5 3.4 3.0 2 1 0 3 3 3 0 Prefoldin subunit Spc24 PF08286.11 EEA24516.1 - 5.4 7.3 13.2 0.081 13.2 2.7 3.0 2 1 1 3 3 2 0 Spc24 subunit of Ndc80 SlyX PF04102.12 EEA24516.1 - 7 7.4 9.2 3.2 8.4 3.4 3.0 2 1 1 3 3 2 0 SlyX AAA_13 PF13166.6 EEA24516.1 - 8.1 4.9 13.6 0.044 12.4 4.5 1.8 2 0 0 2 2 2 0 AAA domain DUF4094 PF13334.6 EEA24516.1 - 8.8 6.8 7.7 94 3.5 7.7 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) IFT57 PF10498.9 EEA24516.1 - 9.5 5.1 13.5 0.41 9.6 6.7 1.9 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 PigN PF04987.14 EEA24517.1 - 1.7e-164 548.0 39.5 1.7e-164 548.0 39.5 1.7 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EEA24517.1 - 1.3e-08 34.8 2.4 4e-07 29.9 2.1 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EEA24517.1 - 1.1e-07 31.5 0.1 2.3e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EEA24517.1 - 0.00021 20.8 0.0 0.00032 20.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sybindin PF04099.12 EEA24518.1 - 1.5e-25 89.8 0.0 1.8e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EEA24518.1 - 0.0037 17.4 0.1 0.0054 16.9 0.1 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Pkinase PF00069.25 EEA24519.1 - 1.1e-56 192.1 0.2 2.6e-50 171.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24519.1 - 1.2e-35 123.1 0.1 1.2e-33 116.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA24519.1 - 1.1e-08 34.7 0.0 1.6e-07 31.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EEA24519.1 - 0.00044 20.2 0.0 0.0012 18.8 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EEA24519.1 - 0.017 13.9 2.7 0.027 13.3 0.0 2.3 3 0 0 3 3 3 0 Fungal protein kinase AT_hook PF02178.19 EEA24520.1 - 0.0078 16.0 1.5 0.033 14.0 1.5 2.2 1 0 0 1 1 1 1 AT hook motif SRI PF08236.11 EEA24521.1 - 1.1e-20 73.6 15.6 3.4e-20 72.0 15.6 1.9 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 EEA24521.1 - 8.2e-18 65.4 0.6 8.2e-18 65.4 0.6 3.6 3 1 0 3 3 3 1 SET domain AWS PF17907.1 EEA24521.1 - 3.4e-12 46.2 11.2 3.4e-12 46.2 11.2 2.5 2 0 0 2 2 2 1 AWS domain Med26 PF08711.11 EEA24521.1 - 0.00011 22.1 0.1 0.0004 20.3 0.1 2.1 1 0 0 1 1 1 1 TFIIS helical bundle-like domain WW PF00397.26 EEA24521.1 - 0.0092 16.0 0.4 0.023 14.8 0.4 1.7 1 0 0 1 1 1 1 WW domain Pox_H7 PF04787.12 EEA24521.1 - 0.31 11.6 3.7 0.61 10.6 3.7 1.4 1 0 0 1 1 1 0 Late protein H7 eIF-6 PF01912.18 EEA24522.1 - 7.1e-79 263.8 0.8 9.2e-79 263.4 0.8 1.1 1 0 0 1 1 1 1 eIF-6 family Pkinase PF00069.25 EEA24523.1 - 1.9e-48 165.1 0.0 2.6e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24523.1 - 4e-27 95.1 0.0 5.4e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA24523.1 - 0.005 16.2 0.0 0.0096 15.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA24523.1 - 0.01 15.2 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EEA24523.1 - 0.072 13.0 1.2 1.8 8.4 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family BAR PF03114.18 EEA24524.1 - 3.8e-66 223.1 5.0 4.6e-66 222.9 5.0 1.1 1 0 0 1 1 1 1 BAR domain CP12 PF02672.15 EEA24524.1 - 0.0053 17.5 0.0 0.053 14.3 0.0 2.6 1 1 1 2 2 2 1 CP12 domain FliD_N PF02465.18 EEA24524.1 - 0.99 10.1 5.4 12 6.6 0.2 2.5 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Pept_tRNA_hydro PF01195.19 EEA24525.1 - 2.2e-22 79.8 0.0 6.1e-07 29.6 0.0 3.1 3 0 0 3 3 3 3 Peptidyl-tRNA hydrolase DNA_pol3_finger PF17657.1 EEA24525.1 - 0.12 11.7 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha subunit finger domain Cupin_2 PF07883.11 EEA24526.1 - 7.8e-08 31.9 0.2 1.2e-07 31.3 0.2 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EEA24526.1 - 0.022 14.5 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Methyltransf_23 PF13489.6 EEA24528.1 - 1.4e-16 60.8 0.0 2.2e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA24528.1 - 3e-08 34.3 0.0 2.1e-07 31.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA24528.1 - 6.4e-07 29.3 0.0 0.002 17.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EEA24528.1 - 1.5e-06 28.8 0.0 0.0023 18.6 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EEA24528.1 - 0.0034 18.0 0.0 0.015 15.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EEA24528.1 - 0.014 14.9 0.0 0.035 13.6 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EEA24528.1 - 0.054 13.6 0.0 0.081 13.0 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 EEA24528.1 - 0.065 12.8 0.0 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EEA24528.1 - 0.11 11.8 0.0 1.7 7.9 0.0 2.4 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family DAP3 PF10236.9 EEA24529.1 - 5.9e-100 334.5 0.0 7.3e-100 334.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 T2SSE PF00437.20 EEA24529.1 - 0.071 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein RRS1 PF04939.12 EEA24530.1 - 5.9e-58 195.3 1.2 7.3e-58 195.0 1.2 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) MTP18 PF10558.9 EEA24531.1 - 3.6e-82 274.4 0.0 4.9e-82 274.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) ATP19 PF11022.8 EEA24532.1 - 6.9e-27 93.6 0.1 7.7e-27 93.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K DUF3360 PF11840.8 EEA24532.1 - 0.057 12.2 0.2 0.062 12.0 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3360) PHP PF02811.19 EEA24533.1 - 2.4e-16 60.5 0.0 4.3e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 PHP domain ACPS PF01648.20 EEA24533.1 - 5.5e-12 45.8 0.0 9.7e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily FKBP_C PF00254.28 EEA24534.1 - 7e-25 87.2 0.0 7.9e-25 87.0 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Glyco_hydro_9 PF00759.19 EEA24536.1 - 0.15 11.4 0.4 0.2 11.0 0.4 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 IBR PF01485.21 EEA24537.1 - 1.2e-05 25.4 3.8 1.2e-05 25.4 3.8 4.7 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain HTH_Tnp_Tc3_2 PF01498.18 EEA24537.1 - 0.074 13.3 0.3 34 4.8 0.0 3.5 4 0 0 4 4 4 0 Transposase Mobilization_B PF17511.2 EEA24537.1 - 0.076 13.4 0.3 0.43 11.0 0.0 2.4 3 0 0 3 3 3 0 Mobilization protein B Ank_2 PF12796.7 EEA24538.1 - 2.2e-25 89.0 0.0 1.4e-09 38.4 0.0 5.6 3 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA24538.1 - 8.5e-22 77.2 2.5 0.00062 20.3 0.0 7.3 5 3 3 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA24538.1 - 2e-18 64.6 5.7 0.0037 17.7 0.1 8.4 9 0 0 9 9 9 4 Ankyrin repeat Ank PF00023.30 EEA24538.1 - 7e-13 48.4 5.1 0.023 15.1 0.0 7.2 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EEA24538.1 - 4.6e-11 42.7 0.1 0.036 14.4 0.0 5.8 6 0 0 6 6 6 2 Ankyrin repeats (many copies) F-box-like PF12937.7 EEA24538.1 - 7.3e-05 22.6 0.1 0.00019 21.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EEA24538.1 - 0.014 15.3 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 F-box F-box PF00646.33 EEA24538.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 F-box domain DUF4533 PF15047.6 EEA24539.1 - 5.1 6.6 4.5 12 5.4 4.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) DUF948 PF06103.11 EEA24540.1 - 0.1 12.9 0.3 0.24 11.7 0.3 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) PIF2 PF04631.12 EEA24540.1 - 0.19 10.5 0.1 0.33 9.7 0.1 1.3 1 0 0 1 1 1 0 Per os infectivity factor 2 EAP30 PF04157.16 EEA24541.1 - 9.7e-42 142.9 1.0 1.3e-41 142.4 1.0 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 EEA24541.1 - 5.7e-25 86.5 2.2 5.7e-25 86.5 2.2 2.4 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vps36_ESCRT-II PF11605.8 EEA24541.1 - 1.6e-24 85.9 0.0 2.8e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.15 EEA24541.1 - 1.2e-05 25.3 3.5 0.0015 18.5 0.4 2.5 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EEA24541.1 - 0.0022 17.3 0.9 0.0022 17.3 0.9 2.7 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others EutK_C PF16365.5 EEA24541.1 - 0.055 13.5 0.1 0.055 13.5 0.1 2.3 3 0 0 3 3 3 0 Ethanolamine utilization protein EutK C-terminus DUF3646 PF12362.8 EEA24541.1 - 0.1 13.0 0.1 0.24 11.7 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal DZR PF12773.7 EEA24541.1 - 0.67 10.0 4.5 0.91 9.6 0.3 2.3 2 0 0 2 2 2 0 Double zinc ribbon zf-C2H2_4 PF13894.6 EEA24541.1 - 9.2 7.4 6.8 69 4.7 0.3 3.4 2 1 1 3 3 3 0 C2H2-type zinc finger SAC3_GANP PF03399.16 EEA24542.1 - 1.6e-25 90.1 1.1 5.5e-13 49.0 0.1 2.2 1 1 1 2 2 2 2 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EEA24542.1 - 0.00035 20.6 0.0 0.00074 19.5 0.0 1.5 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family TPR_MalT PF17874.1 EEA24542.1 - 0.096 12.0 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 MalT-like TPR region SH3_1 PF00018.28 EEA24543.1 - 8e-23 79.8 0.0 5.2e-11 42.0 0.0 2.8 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EEA24543.1 - 3.4e-15 55.6 0.1 1.3e-06 28.2 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 EEA24543.1 - 2.4e-12 46.8 0.0 5.4e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EEA24543.1 - 3.4e-11 42.7 0.0 3.7e-06 26.5 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EEA24543.1 - 2.2e-07 30.7 0.7 3.8e-07 29.9 0.7 1.4 1 0 0 1 1 1 1 PB1 domain EVI2A PF05399.11 EEA24543.1 - 2.1 7.9 5.5 4 7.0 5.5 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Zn_clus PF00172.18 EEA24544.1 - 1.1e-05 25.4 5.8 2.8e-05 24.1 5.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidase PF01425.21 EEA24545.1 - 4.2e-98 329.3 0.0 1.6e-85 287.8 0.0 2.2 2 0 0 2 2 2 2 Amidase AFG1_ATPase PF03969.16 EEA24546.1 - 3.5e-93 312.4 0.0 1.8e-88 296.8 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 EEA24546.1 - 0.00017 21.5 0.0 0.14 12.0 0.0 2.3 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_14 PF13173.6 EEA24546.1 - 0.007 16.4 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA24546.1 - 0.0078 16.6 0.0 0.56 10.6 0.0 2.8 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EEA24546.1 - 0.02 15.3 0.0 0.05 14.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA24546.1 - 0.037 14.3 0.0 0.2 11.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA24546.1 - 0.041 14.3 0.0 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AFG1_ATPase PF03969.16 EEA24547.1 - 5.7e-92 308.4 0.0 3.7e-87 292.6 0.0 2.0 2 0 0 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 EEA24547.1 - 7.5e-05 22.7 0.0 0.086 12.7 0.0 2.3 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_16 PF13191.6 EEA24547.1 - 0.0043 17.4 0.0 0.61 10.5 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 EEA24547.1 - 0.0044 17.0 0.0 0.009 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EEA24547.1 - 0.013 15.9 0.0 0.031 14.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA24547.1 - 0.022 15.1 0.0 0.13 12.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA24547.1 - 0.044 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Methyltransf_31 PF13847.6 EEA24547.1 - 0.18 11.6 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TGT PF01702.18 EEA24548.1 - 1.8e-144 481.2 0.0 2.2e-144 481.0 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase TGT PF01702.18 EEA24549.1 - 2.2e-106 355.9 0.0 3e-106 355.5 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DND1_DSRM PF14709.7 EEA24550.1 - 0.002 18.3 0.0 0.24 11.7 0.0 2.1 2 0 0 2 2 2 2 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.26 EEA24550.1 - 0.11 13.2 0.1 0.25 12.1 0.1 1.6 1 1 0 1 1 1 0 Double-stranded RNA binding motif ECM1 PF05782.11 EEA24551.1 - 0.16 10.9 1.1 0.42 9.5 1.1 1.6 1 1 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) R3H-assoc PF13902.6 EEA24552.1 - 5.7e-23 81.8 9.9 7.2e-23 81.4 9.1 1.7 1 1 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.22 EEA24552.1 - 0.00035 20.5 0.0 0.033 14.2 0.0 2.7 2 0 0 2 2 2 1 R3H domain DDHD PF02862.17 EEA24552.1 - 0.024 14.8 0.2 0.039 14.1 0.2 1.3 1 0 0 1 1 1 0 DDHD domain Vfa1 PF08432.10 EEA24552.1 - 2.1 8.6 9.1 4.1 7.7 9.1 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Inositol_P PF00459.25 EEA24553.1 - 6.1e-34 117.8 0.1 1.2e-33 116.9 0.1 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family Peptidase_M28 PF04389.17 EEA24553.1 - 4e-26 92.0 0.1 6.6e-26 91.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EEA24553.1 - 0.00017 21.3 0.0 0.00031 20.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF4363 PF14276.6 EEA24554.1 - 0.024 14.7 0.2 0.075 13.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) RhoGEF PF00621.20 EEA24554.1 - 0.31 11.3 2.7 1.6 9.0 2.7 2.2 1 1 0 1 1 1 0 RhoGEF domain zf-C3HC4 PF00097.25 EEA24555.1 - 1.8 8.5 8.5 2.8 7.9 5.3 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA24555.1 - 3.3 7.6 7.4 11 6.0 4.1 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1774 PF08611.10 EEA24556.1 - 1.1e-34 118.7 4.4 1.1e-34 118.7 4.4 2.8 3 1 0 3 3 3 1 Fungal protein of unknown function (DUF1774) Cu-oxidase_3 PF07732.15 EEA24557.1 - 1e-39 135.2 1.9 5e-38 129.8 0.1 2.8 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA24557.1 - 1.7e-36 125.0 1.5 2.2e-33 114.9 0.1 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EEA24557.1 - 8.7e-14 51.9 0.0 1e-11 45.2 0.0 3.2 3 0 0 3 3 3 1 Multicopper oxidase Phosphoesterase PF04185.14 EEA24558.1 - 8.1e-69 232.5 6.2 1.3e-68 231.8 6.2 1.3 1 0 0 1 1 1 1 Phosphoesterase family Fascin PF06268.13 EEA24558.1 - 0.00011 22.4 0.2 0.0006 20.0 0.1 2.1 1 1 1 2 2 2 1 Fascin domain PIN7 PF18475.1 EEA24558.1 - 0.025 15.2 0.1 15 6.3 0.1 2.5 2 0 0 2 2 2 0 PIN domain PAD_M PF08527.10 EEA24558.1 - 0.095 12.4 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain Chitin_synth_1 PF01644.17 EEA24559.1 - 1.3e-78 262.6 0.2 2e-78 262.0 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EEA24559.1 - 2.7e-28 97.7 0.2 5.5e-28 96.7 0.2 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EEA24559.1 - 9.4e-24 83.9 0.4 6.3e-20 71.3 0.0 2.2 1 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EEA24559.1 - 1.6e-07 31.5 0.6 4.7e-07 29.9 0.6 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EEA24559.1 - 0.14 12.1 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF998 PF06197.13 EEA24560.1 - 0.031 13.9 15.0 0.04 13.5 15.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF998) DUF4231 PF14015.6 EEA24560.1 - 1.1 9.8 7.8 8.7 6.9 2.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Rer1 PF03248.13 EEA24560.1 - 3 7.6 8.3 0.44 10.3 3.7 1.9 1 1 1 2 2 2 0 Rer1 family GFO_IDH_MocA PF01408.22 EEA24561.1 - 1e-24 87.6 0.1 1.7e-24 87.0 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EEA24561.1 - 0.0041 17.7 0.1 0.0075 16.9 0.1 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GTF2I PF02946.14 EEA24561.1 - 0.086 12.9 0.0 0.42 10.7 0.0 2.1 2 0 0 2 2 2 0 GTF2I-like repeat Methyltransf_23 PF13489.6 EEA24562.1 - 2.4e-21 76.3 0.0 4.2e-21 75.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA24562.1 - 3.8e-12 46.8 0.0 1.3e-11 45.0 0.0 2.0 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA24562.1 - 2.8e-09 37.5 0.0 5.6e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA24562.1 - 1.1e-08 35.1 0.0 1.7e-07 31.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA24562.1 - 2.5e-08 34.6 0.0 1.9e-07 31.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EEA24562.1 - 2.3e-05 24.6 0.0 5.2e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EEA24562.1 - 0.00042 19.7 0.0 0.005 16.2 0.0 2.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EEA24562.1 - 0.004 16.6 0.0 0.0083 15.6 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EEA24562.1 - 0.0065 16.0 0.0 0.018 14.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EEA24562.1 - 0.015 15.1 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 EEA24562.1 - 0.053 13.3 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EEA24562.1 - 0.092 12.0 0.0 0.27 10.5 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 EEA24562.1 - 0.14 11.4 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain DUF938 PF06080.12 EEA24562.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) zf-AN1 PF01428.16 EEA24563.1 - 1.6e-23 82.6 27.7 1.2e-11 44.6 10.9 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 EEA24563.1 - 0.0058 16.8 20.0 0.0077 16.4 4.3 2.6 2 1 0 2 2 2 2 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 EEA24563.1 - 0.41 11.0 14.1 0.16 12.4 2.8 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Hist_deacetyl PF00850.19 EEA24564.1 - 1e-52 179.5 0.0 1.9e-52 178.7 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain RTP801_C PF07809.11 EEA24564.1 - 0.064 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 RTP801 C-terminal region Ala_racemase_N PF01168.20 EEA24565.1 - 1.5e-17 64.0 0.1 2.8e-17 63.1 0.0 1.4 2 0 0 2 2 2 1 Alanine racemase, N-terminal domain Adaptin_N PF01602.20 EEA24566.1 - 3.3e-128 428.5 4.9 3.9e-128 428.3 4.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EEA24566.1 - 8.4e-46 154.8 0.0 2e-45 153.6 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EEA24566.1 - 1.3e-20 73.8 0.1 3.5e-20 72.4 0.0 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 EEA24566.1 - 4.8e-05 23.5 0.6 0.0051 16.9 0.0 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Homeodomain PF00046.29 EEA24568.1 - 9.3e-17 60.6 4.1 1.9e-16 59.6 4.1 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EEA24568.1 - 0.04 13.8 0.1 0.13 12.1 0.1 1.9 1 0 0 1 1 1 0 Homeobox KN domain efThoc1 PF11957.8 EEA24569.1 - 3.6e-151 504.2 4.7 5.5e-151 503.6 4.7 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Aquarius_N PF16399.5 EEA24570.1 - 0 1092.0 0.4 0 1091.6 0.4 1.2 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EEA24570.1 - 2.2e-28 99.3 0.0 4.7e-28 98.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EEA24570.1 - 2e-22 80.2 0.0 5.3e-22 78.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA24570.1 - 1.3e-07 31.5 0.0 0.00038 20.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EEA24570.1 - 2.1e-06 28.1 0.0 8.7e-06 26.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EEA24570.1 - 1.5e-05 25.1 0.0 3.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EEA24570.1 - 0.0004 20.0 1.1 0.011 15.2 0.1 3.0 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EEA24570.1 - 0.0038 17.0 0.1 0.3 10.8 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase DnaB_C PF03796.15 EEA24570.1 - 0.0061 15.9 0.0 0.025 13.9 0.0 1.9 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain UvrD_C_2 PF13538.6 EEA24570.1 - 0.0063 16.3 1.4 0.018 14.8 0.3 2.3 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA PF00004.29 EEA24570.1 - 0.0095 16.4 0.0 0.026 15.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA24570.1 - 0.022 15.1 1.5 0.05 14.0 0.0 2.3 3 0 0 3 3 2 0 AAA ATPase domain AAA_5 PF07728.14 EEA24570.1 - 0.031 14.3 0.0 0.07 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 EEA24570.1 - 0.07 12.4 1.1 0.13 11.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 EEA24570.1 - 0.086 12.6 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA24570.1 - 0.12 12.6 0.0 0.62 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EEA24570.1 - 0.17 10.9 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 4HBT PF03061.22 EEA24571.1 - 3.6e-15 56.1 0.0 4.9e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EEA24571.1 - 0.14 12.3 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) Tfb2 PF03849.14 EEA24572.1 - 8.6e-138 459.1 0.0 1.5e-137 458.3 0.0 1.4 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EEA24572.1 - 1.3e-22 80.0 0.1 2.8e-22 78.9 0.1 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EEA24572.1 - 3.1e-05 24.1 0.0 7.8e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Tfb2 PF03849.14 EEA24573.1 - 4.8e-100 335.0 0.0 1e-99 333.9 0.0 1.5 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EEA24573.1 - 1.2e-22 80.1 0.1 2.3e-22 79.2 0.1 1.5 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EEA24573.1 - 2.8e-05 24.3 0.0 6.5e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhzC-PhzF PF02567.16 EEA24574.1 - 6.2e-40 137.4 0.0 2.3e-39 135.6 0.0 1.7 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein TIMELESS PF04821.14 EEA24575.1 - 4.3e-86 288.6 0.5 4.3e-86 288.6 0.5 2.2 2 0 0 2 2 2 1 Timeless protein TIMELESS_C PF05029.13 EEA24575.1 - 1.1e-46 160.2 0.0 1.1e-46 160.2 0.0 4.4 2 1 1 3 3 3 1 Timeless protein C terminal region 3HCDH_N PF02737.18 EEA24576.1 - 6.4e-53 179.3 0.5 1e-52 178.7 0.5 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EEA24576.1 - 1.7e-34 118.3 0.0 4.8e-34 116.8 0.0 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Sacchrp_dh_NADP PF03435.18 EEA24576.1 - 0.00025 21.3 0.1 0.00054 20.2 0.1 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EEA24576.1 - 0.00076 19.7 0.4 0.0024 18.1 0.4 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EEA24576.1 - 0.021 14.2 0.3 0.034 13.5 0.3 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 EEA24576.1 - 0.024 14.2 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA24576.1 - 0.056 12.7 0.0 0.07 12.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EEA24576.1 - 0.11 12.0 0.2 0.23 11.0 0.2 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EEA24576.1 - 0.11 12.7 0.1 0.79 10.0 0.1 2.2 2 0 0 2 2 2 0 TrkA-N domain FeoC PF09012.10 EEA24576.1 - 0.16 12.1 0.0 0.48 10.5 0.0 1.7 1 0 0 1 1 1 0 FeoC like transcriptional regulator RsbU_N PF08673.10 EEA24576.1 - 0.17 12.0 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain F420_oxidored PF03807.17 EEA24576.1 - 0.32 11.6 1.9 1.1 9.8 1.6 2.2 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Actin PF00022.19 EEA24577.1 - 2.7e-103 345.7 0.0 1.4e-102 343.3 0.0 1.8 1 1 0 1 1 1 1 Actin CC2-LZ PF16516.5 EEA24577.1 - 0.015 15.6 0.1 0.036 14.4 0.1 1.5 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator GCIP PF13324.6 EEA24578.1 - 1.5e-23 83.7 6.0 2.3e-23 83.1 6.0 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting DUF4085 PF13315.6 EEA24578.1 - 0.0088 15.7 4.4 0.96 9.0 1.2 3.1 2 1 0 2 2 2 2 Protein of unknown function (DUF4085) DUF4611 PF15387.6 EEA24578.1 - 0.53 10.5 13.0 29 5.0 8.7 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4611) Tcp11 PF05794.13 EEA24578.1 - 0.74 8.8 3.9 0.92 8.5 2.3 1.9 1 1 1 2 2 2 0 T-complex protein 11 Importin_rep_6 PF18829.1 EEA24578.1 - 0.77 9.9 3.4 2.4 8.3 3.2 2.1 1 1 0 1 1 1 0 Importin repeat 6 YL1 PF05764.13 EEA24578.1 - 1.8 8.6 10.1 0.23 11.6 5.1 1.9 2 0 0 2 2 2 0 YL1 nuclear protein LRR_8 PF13855.6 EEA24579.1 - 6.8e-23 80.2 62.8 1.1e-05 25.0 8.1 8.7 5 2 4 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 EEA24579.1 - 2.1e-21 75.6 63.5 0.00092 19.6 2.5 11.2 3 3 6 12 12 12 12 Leucine Rich repeats (2 copies) LRRFIP PF09738.9 EEA24579.1 - 0.064 12.7 1.5 0.13 11.8 1.5 1.4 1 0 0 1 1 1 0 LRRFIP family LRR_1 PF00560.33 EEA24579.1 - 0.065 13.8 54.3 6 7.8 0.3 12.8 12 2 0 12 12 12 0 Leucine Rich Repeat Rootletin PF15035.6 EEA24580.1 - 0.049 13.6 7.8 0.092 12.8 7.8 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Ribosomal_L13e PF01294.18 EEA24581.1 - 1.1e-76 256.6 4.6 1.5e-76 256.3 4.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e BLOC1_2 PF10046.9 EEA24582.1 - 0.24 11.7 2.2 4.7 7.6 0.2 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin-6_N PF09177.11 EEA24582.1 - 4.8 7.8 6.3 7.2 7.2 2.5 2.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Oxidored-like PF09791.9 EEA24583.1 - 3.9e-24 84.0 3.5 8.4e-24 83.0 3.5 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF5522 PF17653.1 EEA24583.1 - 0.063 13.2 3.1 0.12 12.3 3.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5522) KAP PF05804.12 EEA24584.1 - 0.0002 19.7 0.2 0.003 15.8 0.1 2.1 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) RICTOR_V PF14668.6 EEA24584.1 - 0.0036 17.5 0.5 5.2 7.4 0.1 4.2 3 1 2 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 Rpr2 PF04032.16 EEA24584.1 - 0.0045 17.2 0.0 0.013 15.8 0.0 1.8 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Phage_integrase PF00589.22 EEA24584.1 - 0.14 11.9 0.0 0.43 10.4 0.0 1.8 1 0 0 1 1 1 0 Phage integrase family FPL PF09758.9 EEA24584.1 - 0.57 10.2 5.0 0.49 10.4 1.6 2.5 2 1 0 2 2 2 0 Uncharacterised conserved protein DPM3 PF08285.11 EEA24585.1 - 3e-31 107.5 0.2 3.3e-31 107.3 0.2 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LapA_dom PF06305.11 EEA24585.1 - 0.0017 18.2 0.1 0.019 14.8 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain EMC3_TMCO1 PF01956.16 EEA24585.1 - 0.02 14.7 0.0 0.027 14.2 0.0 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like LGT PF01790.18 EEA24585.1 - 0.038 13.2 0.1 0.044 13.0 0.1 1.2 1 0 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase DUF1043 PF06295.12 EEA24585.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DPM3 PF08285.11 EEA24586.1 - 5.3e-25 87.4 0.1 5.5e-25 87.4 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LapA_dom PF06305.11 EEA24586.1 - 0.009 15.8 0.1 0.017 14.9 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain EMC3_TMCO1 PF01956.16 EEA24586.1 - 0.016 14.9 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like LGT PF01790.18 EEA24586.1 - 0.084 12.1 0.0 0.094 11.9 0.0 1.1 1 0 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase DUF1043 PF06295.12 EEA24586.1 - 0.092 12.7 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Pribosyltran PF00156.27 EEA24587.1 - 4.1e-08 32.9 0.0 6.7e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Caskin-tail PF16632.5 EEA24587.1 - 0.15 12.5 0.1 30 5.1 0.0 2.3 2 0 0 2 2 2 0 C-terminal region of Caskin adh_short PF00106.25 EEA24588.1 - 2.8e-41 141.2 0.0 3.4e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24588.1 - 6.9e-28 97.8 0.0 8.7e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EEA24588.1 - 9.4e-05 21.9 0.0 0.00066 19.1 0.0 1.9 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EEA24588.1 - 0.0011 18.6 0.0 0.0027 17.3 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EEA24588.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding MGS PF02142.22 EEA24588.1 - 0.18 12.0 0.0 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 MGS-like domain ATP-grasp_2 PF08442.10 EEA24589.1 - 2.4e-76 255.8 1.7 2.9e-76 255.5 0.4 1.7 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EEA24589.1 - 1.1e-23 83.7 0.2 2.4e-23 82.7 0.2 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EEA24589.1 - 7.8e-09 35.3 0.7 1.9e-08 34.1 0.3 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EEA24589.1 - 0.00046 20.0 0.8 0.026 14.3 0.2 2.6 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Succ_CoA_lig PF13607.6 EEA24589.1 - 0.037 13.8 0.1 5.4 6.8 0.0 2.6 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain VID27_N PF17748.1 EEA24589.1 - 0.12 12.3 0.5 0.22 11.4 0.5 1.3 1 0 0 1 1 1 0 VID27 N-terminal region AA_permease_2 PF13520.6 EEA24590.1 - 2.8e-63 214.2 49.0 3.3e-63 214.0 49.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA24590.1 - 2.8e-22 79.0 44.3 3.9e-22 78.5 44.3 1.1 1 0 0 1 1 1 1 Amino acid permease PDGLE PF13190.6 EEA24590.1 - 0.12 12.3 0.6 3 7.8 0.0 3.3 3 0 0 3 3 3 0 PDGLE domain p450 PF00067.22 EEA24591.1 - 2.2e-43 148.7 0.0 9e-43 146.7 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 DUF5367 PF17329.2 EEA24591.1 - 0.046 13.9 0.1 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5367) Amidase PF01425.21 EEA24592.1 - 2.9e-73 247.4 1.3 8.1e-73 245.9 1.3 1.7 1 1 0 1 1 1 1 Amidase adh_short PF00106.25 EEA24593.1 - 2.6e-40 138.0 0.0 4.9e-40 137.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24593.1 - 4.3e-35 121.4 0.0 1.2e-34 119.9 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24593.1 - 2.7e-09 37.2 0.1 4.6e-07 29.9 0.0 2.2 2 0 0 2 2 2 2 KR domain CIMR PF00878.18 EEA24593.1 - 0.0094 16.0 0.0 3.1 7.8 0.0 2.2 1 1 1 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Epimerase PF01370.21 EEA24593.1 - 0.053 13.0 0.1 2.2 7.7 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 EEA24594.1 - 3.5e-35 121.7 0.0 2.2e-34 119.1 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA24594.1 - 8.6e-29 100.4 0.0 1.2e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA24594.1 - 2.1e-09 37.5 0.0 3e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA24594.1 - 0.00047 20.1 0.0 0.00075 19.4 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA24594.1 - 0.00067 19.2 0.0 0.00086 18.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA24594.1 - 0.028 13.8 0.0 0.038 13.4 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ISN1 PF06437.11 EEA24594.1 - 0.031 13.2 0.0 0.056 12.4 0.0 1.4 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase NmrA PF05368.13 EEA24594.1 - 0.047 13.2 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family THF_DHG_CYH_C PF02882.19 EEA24594.1 - 0.064 12.6 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Fungal_trans_2 PF11951.8 EEA24595.1 - 4.9e-11 42.1 2.9 1.2e-10 40.8 2.9 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain NPV_P10 PF05531.12 EEA24595.1 - 0.094 13.2 0.9 24 5.5 0.1 3.1 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Env-gp36 PF09590.10 EEA24595.1 - 0.15 10.4 0.1 0.21 9.9 0.1 1.1 1 0 0 1 1 1 0 Lentivirus surface glycoprotein p450 PF00067.22 EEA24596.1 - 5.7e-57 193.5 0.0 6.5e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_1 PF00561.20 EEA24597.1 - 5.5e-14 52.4 0.1 1.3e-12 47.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA24597.1 - 2.5e-06 28.3 0.0 3.9e-06 27.6 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA24597.1 - 0.00061 19.1 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ribonuc_L-PSP PF01042.21 EEA24598.1 - 6.6e-18 64.9 0.0 9.1e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP NOGCT PF08155.11 EEA24598.1 - 0.032 14.2 0.2 0.18 11.8 0.1 2.1 2 0 0 2 2 2 0 NOGCT (NUC087) domain Fungal_trans PF04082.18 EEA24599.1 - 1.8e-24 86.2 0.1 3e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24599.1 - 5.4e-06 26.4 14.7 8.4e-06 25.8 14.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA24600.1 - 1.4e-28 99.8 50.5 2.2e-28 99.2 43.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA24600.1 - 5.6e-06 25.5 32.4 0.00045 19.2 15.3 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 EEA24600.1 - 2.1e-05 23.6 26.0 0.0062 15.5 8.8 2.3 2 0 0 2 2 2 2 MFS_1 like family HSF_DNA-bind PF00447.17 EEA24602.1 - 5.5e-30 103.8 2.1 5.5e-30 103.8 2.1 2.3 3 0 0 3 3 1 1 HSF-type DNA-binding Spt20 PF12090.8 EEA24602.1 - 0.001 18.7 25.6 0.0026 17.4 25.2 1.9 2 0 0 2 2 2 1 Spt20 family CCDC53 PF10152.9 EEA24602.1 - 0.0032 17.9 3.7 0.0095 16.4 3.7 1.9 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex eIF-3_zeta PF05091.12 EEA24602.1 - 0.0083 15.2 3.6 0.012 14.7 3.6 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 EEA24602.1 - 0.079 11.7 3.5 0.11 11.2 3.5 1.2 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 EEA24602.1 - 0.093 12.7 15.6 0.018 15.0 11.9 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4834 PF16118.5 EEA24602.1 - 0.21 12.5 7.1 0.6 11.1 7.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) BRF1 PF07741.13 EEA24602.1 - 0.27 11.6 6.7 0.64 10.4 6.7 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain EIIBC-GUT_N PF03612.14 EEA24602.1 - 0.28 10.9 2.4 0.55 9.9 2.4 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4407 PF14362.6 EEA24602.1 - 0.29 10.4 4.3 0.5 9.7 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 EEA24602.1 - 0.41 10.7 2.4 0.78 9.8 2.4 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 EEA24602.1 - 0.51 9.8 5.9 1.2 8.6 5.9 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RLL PF10036.9 EEA24602.1 - 0.73 9.6 9.1 6.1 6.6 8.0 2.1 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein DUF4770 PF15994.5 EEA24602.1 - 0.8 9.9 9.8 1.6 8.9 9.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PAT1 PF09770.9 EEA24602.1 - 0.83 7.8 17.6 1.1 7.4 17.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CobT PF06213.12 EEA24602.1 - 1 8.7 11.2 2.2 7.6 11.2 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3464 PF11947.8 EEA24602.1 - 1.9 8.2 8.5 6.7 6.5 9.0 1.6 2 0 0 2 2 1 0 Photosynthesis affected mutant 68 CPSF100_C PF13299.6 EEA24602.1 - 3.4 7.8 5.8 6.9 6.8 5.8 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3245 PF11595.8 EEA24603.1 - 4.1e-29 102.0 8.6 4.1e-29 102.0 8.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3245) DUF2052 PF09747.9 EEA24603.1 - 0.086 13.0 11.0 0.13 12.4 11.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SUIM_assoc PF16619.5 EEA24603.1 - 0.39 10.8 18.2 0.2 11.8 3.7 2.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 SAPS PF04499.15 EEA24603.1 - 1.8 7.3 11.1 2.3 6.9 11.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ycf1 PF05758.12 EEA24603.1 - 2.9 5.7 5.7 3.8 5.3 5.7 1.1 1 0 0 1 1 1 0 Ycf1 PGA2 PF07543.12 EEA24603.1 - 3.3 7.7 19.2 0.27 11.2 14.3 1.8 2 0 0 2 2 2 0 Protein trafficking PGA2 Neur_chan_memb PF02932.16 EEA24603.1 - 4.1 7.4 9.3 5.8 6.9 9.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ABC1 PF03109.16 EEA24605.1 - 1e-20 74.0 0.1 2.3e-11 43.9 0.0 2.8 3 0 0 3 3 3 2 ABC1 family RIO1 PF01163.22 EEA24605.1 - 0.037 13.6 0.0 0.091 12.4 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Cyto_heme_lyase PF01265.17 EEA24606.1 - 1.7e-125 418.5 4.5 1.9e-125 418.3 4.5 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase UQ_con PF00179.26 EEA24607.1 - 1.4e-19 70.2 0.1 2e-19 69.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Bac_surface_Ag PF01103.23 EEA24609.1 - 1.5e-45 156.1 0.2 1.9e-45 155.7 0.2 1.1 1 0 0 1 1 1 1 Surface antigen Yip1 PF04893.17 EEA24610.1 - 7.9e-07 29.0 16.3 0.00018 21.3 9.3 2.4 2 0 0 2 2 2 2 Yip1 domain UFD1 PF03152.14 EEA24611.1 - 3.4e-30 104.8 0.0 1.9e-26 92.6 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 EEA24611.1 - 3.8e-06 27.0 0.3 1.7e-05 24.9 0.3 2.1 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A zinc_ribbon_4 PF13717.6 EEA24611.1 - 1.5 8.8 5.9 14 5.7 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon domain F-box-like PF12937.7 EEA24612.1 - 0.045 13.6 0.1 0.62 10.0 0.0 2.4 2 0 0 2 2 2 0 F-box-like AAA PF00004.29 EEA24613.1 - 1e-43 148.9 0.0 1.7e-43 148.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA24613.1 - 4.9e-14 51.9 0.0 1e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EEA24613.1 - 9.8e-08 32.3 0.0 1.9e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EEA24613.1 - 6.3e-07 29.5 0.0 1.6e-06 28.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA24613.1 - 1.1e-06 29.2 0.0 4.3e-05 24.0 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 EEA24613.1 - 4e-06 26.7 2.9 1e-05 25.4 2.9 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EEA24613.1 - 1.4e-05 25.4 0.2 0.0063 16.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EEA24613.1 - 6.5e-05 22.7 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EEA24613.1 - 0.00045 20.8 0.0 0.028 15.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EEA24613.1 - 0.0011 18.8 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EEA24613.1 - 0.0011 18.2 0.0 0.0023 17.2 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EEA24613.1 - 0.002 18.3 0.0 0.004 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EEA24613.1 - 0.0053 16.6 0.0 0.015 15.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EEA24613.1 - 0.0078 15.6 0.0 0.019 14.3 0.0 1.6 1 0 0 1 1 1 1 KaiC Mg_chelatase PF01078.21 EEA24613.1 - 0.0079 15.6 0.1 0.018 14.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EEA24613.1 - 0.01 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EEA24613.1 - 0.012 15.9 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EEA24613.1 - 0.021 14.0 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EEA24613.1 - 0.021 14.5 0.0 0.094 12.4 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EEA24613.1 - 0.026 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 EEA24613.1 - 0.026 14.0 0.0 0.1 12.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein HR1 PF02185.16 EEA24613.1 - 0.038 14.1 0.8 0.095 12.8 0.8 1.7 1 0 0 1 1 1 0 Hr1 repeat RNA_helicase PF00910.22 EEA24613.1 - 0.038 14.4 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EEA24613.1 - 0.04 13.6 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EEA24613.1 - 0.042 13.9 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EEA24613.1 - 0.066 12.8 0.1 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Prot_ATP_OB_N PF17758.1 EEA24613.1 - 0.069 12.8 0.2 0.24 11.1 0.2 2.0 1 1 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain Parvo_NS1 PF01057.17 EEA24613.1 - 0.09 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EEA24613.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF2072 PF09845.9 EEA24613.1 - 0.16 12.2 0.1 0.3 11.4 0.1 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein AAA PF00004.29 EEA24614.1 - 7.7e-44 149.3 0.0 1.1e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EEA24614.1 - 6.9e-08 32.8 0.0 1.3e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EEA24614.1 - 4.2e-07 30.0 0.0 1.1e-06 28.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA24614.1 - 2.5e-06 28.0 0.1 3.3e-05 24.3 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 EEA24614.1 - 2.8e-06 27.2 2.9 7.7e-06 25.8 2.9 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EEA24614.1 - 8.3e-06 26.1 0.1 0.0049 17.1 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EEA24614.1 - 4.8e-05 23.2 0.0 9.2e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EEA24614.1 - 0.00084 18.6 0.0 0.0017 17.6 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EEA24614.1 - 0.00086 19.1 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EEA24614.1 - 0.0016 18.6 0.0 0.0026 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EEA24614.1 - 0.0056 16.0 0.0 0.014 14.7 0.0 1.6 1 0 0 1 1 1 1 KaiC Mg_chelatase PF01078.21 EEA24614.1 - 0.0061 16.0 0.1 0.014 14.8 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EEA24614.1 - 0.0061 16.4 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EEA24614.1 - 0.0076 16.8 0.0 0.018 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EEA24614.1 - 0.0077 16.2 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EEA24614.1 - 0.0093 16.2 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EEA24614.1 - 0.014 15.1 0.0 0.071 12.8 0.0 2.1 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF815 PF05673.13 EEA24614.1 - 0.015 14.5 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 EEA24614.1 - 0.018 14.5 0.0 0.079 12.4 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EEA24614.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EEA24614.1 - 0.028 14.8 0.0 0.051 14.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase HR1 PF02185.16 EEA24614.1 - 0.029 14.5 0.8 0.073 13.2 0.8 1.7 1 0 0 1 1 1 0 Hr1 repeat AAA_14 PF13173.6 EEA24614.1 - 0.031 14.3 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EEA24614.1 - 0.036 13.8 0.0 0.079 12.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA24614.1 - 0.048 13.2 0.1 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Prot_ATP_OB_N PF17758.1 EEA24614.1 - 0.054 13.1 0.2 0.19 11.4 0.2 1.9 1 1 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain Parvo_NS1 PF01057.17 EEA24614.1 - 0.074 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 EEA24614.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA24614.1 - 0.12 12.2 0.0 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EEA24614.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF2072 PF09845.9 EEA24614.1 - 0.13 12.5 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein AAA_19 PF13245.6 EEA24614.1 - 0.16 12.3 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EEA24614.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EEA24614.1 - 0.19 11.4 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Na_Ca_ex PF01699.24 EEA24615.1 - 3.6e-21 75.7 34.3 1.9e-15 57.2 12.7 3.8 5 1 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EEA24615.1 - 1e-14 55.0 8.3 1e-14 55.0 8.3 4.6 5 0 0 5 5 5 2 Inner membrane component domain YccF PF03733.13 EEA24616.1 - 9e-15 55.1 8.3 9e-15 55.1 8.3 3.9 4 0 0 4 4 4 2 Inner membrane component domain Na_Ca_ex PF01699.24 EEA24616.1 - 1.3e-10 41.5 22.8 3e-08 33.7 13.8 3.9 5 1 0 5 5 5 2 Sodium/calcium exchanger protein Nic96 PF04097.14 EEA24617.1 - 4.2e-214 712.6 0.0 5.7e-214 712.1 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 COX16 PF14138.6 EEA24618.1 - 1.8e-30 105.2 0.1 2.4e-30 104.9 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 DUF1646 PF07854.12 EEA24618.1 - 0.24 10.7 0.0 0.31 10.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1646) COX16 PF14138.6 EEA24619.1 - 1.8e-30 105.2 0.1 2.4e-30 104.9 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 DUF1646 PF07854.12 EEA24619.1 - 0.24 10.7 0.0 0.31 10.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1646) Y_phosphatase PF00102.27 EEA24620.1 - 8.9e-62 208.7 0.1 4.7e-61 206.3 0.1 2.2 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EEA24620.1 - 2.5e-09 37.6 0.0 1.2e-08 35.5 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EEA24620.1 - 0.041 13.7 0.1 0.13 12.1 0.1 1.9 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EEA24620.1 - 0.045 13.7 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family F-box PF00646.33 EEA24621.1 - 0.0029 17.4 0.5 0.0064 16.4 0.5 1.5 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.6 EEA24621.1 - 0.058 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 F-box-like domain F-box-like PF12937.7 EEA24621.1 - 0.26 11.2 1.2 0.57 10.1 1.2 1.6 1 0 0 1 1 1 0 F-box-like BK_channel_a PF03493.18 EEA24622.1 - 0.019 15.1 0.1 0.034 14.3 0.1 1.4 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit FGGY_C PF02782.16 EEA24623.1 - 7.1e-51 172.8 0.1 1.1e-50 172.2 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EEA24623.1 - 1.6e-22 80.3 0.1 3.9e-21 75.7 0.1 2.5 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EEA24623.1 - 0.009 15.5 0.0 0.092 12.2 0.0 2.2 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family DEDD_Tnp_IS110 PF01548.17 EEA24623.1 - 0.24 11.3 1.2 2.3 8.1 0.2 2.4 2 0 0 2 2 2 0 Transposase Swi3 PF07962.12 EEA24624.1 - 2.6e-35 120.3 0.4 7e-35 118.9 0.6 1.6 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 Med5 PF08689.10 EEA24624.1 - 0.28 9.0 5.2 2.5 5.8 0.2 2.4 1 1 2 3 3 3 0 Mediator complex subunit Med5 NADH-u_ox-rdase PF10785.9 EEA24625.1 - 2.6e-30 104.9 0.1 4.3e-30 104.2 0.1 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 EEA24625.1 - 1.1e-25 89.4 0.1 1.6e-25 88.9 0.1 1.3 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit dCMP_cyt_deam_1 PF00383.23 EEA24626.1 - 8.2e-25 86.6 0.0 1.2e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA24626.1 - 1.6e-21 76.5 0.0 2.1e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EEA24626.1 - 0.00095 19.3 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EEA24626.1 - 0.0038 17.4 0.0 0.006 16.7 0.0 1.2 1 0 0 1 1 1 1 APOBEC3 Bd3614-deam PF14439.6 EEA24626.1 - 0.0091 16.1 0.2 0.042 13.9 0.2 1.9 1 1 0 1 1 1 1 Bd3614-like deaminase NAD1 PF18778.1 EEA24626.1 - 0.027 14.6 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC4_like PF18774.1 EEA24626.1 - 0.049 13.6 0.0 0.075 13.0 0.0 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase XOO_2897-deam PF14440.6 EEA24626.1 - 0.054 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase APOBEC_N PF08210.11 EEA24626.1 - 0.062 13.2 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain APOBEC2 PF18772.1 EEA24626.1 - 0.089 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 APOBEC2 PI3_PI4_kinase PF00454.27 EEA24627.1 - 1.2e-49 169.4 0.1 3.1e-49 168.1 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EEA24627.1 - 3.4e-38 131.8 2.4 7.3e-38 130.7 1.5 2.0 2 0 0 2 2 2 1 FAT domain UME PF08064.13 EEA24627.1 - 1.4e-31 108.4 0.2 7.3e-31 106.1 0.2 2.4 1 0 0 1 1 1 1 UME (NUC010) domain TPR_19 PF14559.6 EEA24627.1 - 0.012 16.1 0.4 0.11 13.0 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24627.1 - 0.2 12.6 4.3 2.2e+02 3.1 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.17 EEA24627.1 - 0.41 11.1 2.3 0.66 10.4 0.1 2.6 3 0 0 3 3 3 0 Bacterial transcriptional activator domain RRM_1 PF00076.22 EEA24628.1 - 3.9e-15 55.4 0.0 5.5e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA24628.1 - 0.0026 17.3 0.0 0.004 16.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA24628.1 - 0.077 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EEA24628.1 - 0.083 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif RRM_3 PF08777.11 EEA24628.1 - 0.21 11.6 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif AAA PF00004.29 EEA24629.1 - 1.2e-62 210.2 0.0 5.4e-40 136.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA24629.1 - 1.8e-16 59.6 0.3 7.5e-11 41.7 0.2 3.0 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EEA24629.1 - 1.1e-11 45.4 2.4 0.0039 17.6 0.1 4.5 2 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 EEA24629.1 - 7.8e-08 32.7 0.8 0.17 12.2 0.1 4.0 2 2 2 4 4 4 2 AAA domain AAA_5 PF07728.14 EEA24629.1 - 9.4e-07 28.9 0.8 0.056 13.4 0.1 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EEA24629.1 - 7.8e-06 25.9 0.0 0.096 12.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EEA24629.1 - 1.3e-05 25.2 0.0 0.0014 18.6 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain Bac_DnaA PF00308.18 EEA24629.1 - 2.2e-05 24.4 0.0 0.0021 17.9 0.0 2.8 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_28 PF13521.6 EEA24629.1 - 3.2e-05 24.2 0.0 0.13 12.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EEA24629.1 - 3.6e-05 23.7 0.8 0.5 10.3 0.1 3.6 2 2 1 3 3 3 2 NACHT domain AAA_25 PF13481.6 EEA24629.1 - 9.6e-05 22.0 0.1 0.25 10.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EEA24629.1 - 0.00018 21.0 0.0 0.2 11.1 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 EEA24629.1 - 0.0002 21.5 0.0 0.85 9.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EEA24629.1 - 0.0002 21.1 0.0 0.83 9.4 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein RuvB_N PF05496.12 EEA24629.1 - 0.00021 21.1 0.0 0.0061 16.3 0.0 3.0 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EEA24629.1 - 0.00027 21.3 0.0 0.82 10.1 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_2 PF07724.14 EEA24629.1 - 0.00048 20.3 0.0 0.088 12.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EEA24629.1 - 0.001 18.4 0.1 0.07 12.3 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 EEA24629.1 - 0.002 17.3 0.1 1.1 8.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ATPase_2 PF01637.18 EEA24629.1 - 0.0026 17.7 0.8 4.8 7.0 0.0 3.8 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EEA24629.1 - 0.0067 16.2 0.0 0.36 10.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EEA24629.1 - 0.0068 16.9 0.8 1.2 9.6 0.1 3.0 3 1 0 3 3 2 1 ABC transporter AAA_18 PF13238.6 EEA24629.1 - 0.007 16.9 0.2 4.4 7.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EEA24629.1 - 0.0075 15.7 0.2 1.5 8.1 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EEA24629.1 - 0.015 14.7 0.0 3 7.1 0.0 3.0 3 0 0 3 3 3 0 KaiC Sigma54_activ_2 PF14532.6 EEA24629.1 - 0.019 15.1 0.0 0.87 9.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 EEA24629.1 - 0.023 14.5 0.0 5.5 6.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EEA24629.1 - 0.027 14.9 0.1 9.2 6.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EEA24629.1 - 0.039 13.7 0.0 4.9 6.8 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase TniB PF05621.11 EEA24629.1 - 0.04 13.3 0.0 9.9 5.5 0.0 3.5 3 1 0 4 4 4 0 Bacterial TniB protein AAA_23 PF13476.6 EEA24629.1 - 0.064 13.8 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EEA24629.1 - 0.071 12.8 0.0 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EEA24629.1 - 0.073 12.8 0.0 0.51 10.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 EEA24629.1 - 0.084 12.9 0.0 8.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EEA24629.1 - 0.14 11.9 0.0 8.7 6.0 0.0 3.0 2 1 1 3 3 3 0 Sigma-54 interaction domain Adeno_IVa2 PF02456.15 EEA24629.1 - 0.29 9.9 0.7 3.9 6.2 0.1 2.5 3 0 0 3 3 3 0 Adenovirus IVa2 protein Ras PF00071.22 EEA24630.1 - 2.1e-65 219.3 0.0 2.4e-65 219.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA24630.1 - 6.4e-34 116.8 0.0 1e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA24630.1 - 2e-13 50.2 0.0 2.4e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA24630.1 - 6e-06 25.9 0.1 3.4e-05 23.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EEA24630.1 - 0.00016 21.1 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EEA24630.1 - 0.00067 19.6 0.2 0.65 9.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EEA24630.1 - 0.0039 17.2 0.0 0.0082 16.2 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA24630.1 - 0.023 14.2 0.0 0.13 11.8 0.0 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA PF00004.29 EEA24630.1 - 0.065 13.7 0.0 8.1 6.9 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA24630.1 - 0.088 13.1 0.1 0.77 10.0 0.0 2.1 1 1 0 2 2 2 0 AAA domain NCA2 PF08637.10 EEA24631.1 - 7.1e-101 337.2 0.0 1.4e-100 336.2 0.0 1.5 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 RNase_H PF00075.24 EEA24632.1 - 3.6e-07 30.4 0.0 6.3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 EEA24632.1 - 3.3e-05 24.5 0.0 6.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase HTH_Tnp_Tc3_2 PF01498.18 EEA24633.1 - 1.8e-11 44.1 0.2 2.3e-10 40.6 0.0 2.5 3 0 0 3 3 3 1 Transposase HTH_32 PF13565.6 EEA24633.1 - 4.6e-07 30.4 7.1 7e-06 26.6 0.1 4.1 3 2 1 4 4 4 1 Homeodomain-like domain HTH_23 PF13384.6 EEA24633.1 - 1.5e-06 27.8 0.0 1.3e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 EEA24633.1 - 0.0028 17.8 0.7 0.083 13.0 0.0 3.0 3 0 0 3 3 3 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 EEA24633.1 - 0.0046 16.6 0.1 0.017 14.8 0.1 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 TrmB PF01978.19 EEA24633.1 - 0.011 15.6 0.1 0.077 12.9 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HRDC PF00570.23 EEA24633.1 - 0.092 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 HRDC domain DUF835 PF05763.12 EEA24633.1 - 0.48 10.1 1.9 2 8.1 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF835) HTH_Tnp_Tc3_2 PF01498.18 EEA24634.1 - 1.8e-11 44.1 0.2 2.3e-10 40.6 0.0 2.5 3 0 0 3 3 3 1 Transposase HTH_32 PF13565.6 EEA24634.1 - 4.6e-07 30.4 7.1 7e-06 26.6 0.1 4.1 3 2 1 4 4 4 1 Homeodomain-like domain HTH_23 PF13384.6 EEA24634.1 - 1.5e-06 27.8 0.0 1.3e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 EEA24634.1 - 0.0028 17.8 0.7 0.083 13.0 0.0 3.0 3 0 0 3 3 3 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 EEA24634.1 - 0.0046 16.6 0.1 0.017 14.8 0.1 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 TrmB PF01978.19 EEA24634.1 - 0.011 15.6 0.1 0.077 12.9 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HRDC PF00570.23 EEA24634.1 - 0.092 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 HRDC domain DUF835 PF05763.12 EEA24634.1 - 0.48 10.1 1.9 2 8.1 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF835) DDE_3 PF13358.6 EEA24635.1 - 3.3e-06 26.9 0.1 5.1e-06 26.3 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EEA24636.1 - 7.2e-13 48.5 0.1 2.1e-12 47.0 0.1 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA24636.1 - 6.4e-10 39.1 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA24636.1 - 0.0015 18.3 1.6 0.0061 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA24636.1 - 0.0076 16.2 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA24636.1 - 0.009 15.8 0.1 0.022 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 EEA24636.1 - 0.011 16.3 10.8 0.13 12.9 0.5 3.7 2 1 2 4 4 4 0 Homeodomain-like domain DUF4350 PF14258.6 EEA24636.1 - 0.014 15.8 0.1 14 6.2 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4350) HTH_33 PF13592.6 EEA24636.1 - 0.033 13.8 1.2 6.9 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA24636.1 - 0.041 14.0 0.0 8.9 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA24636.1 - 0.18 12.0 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA24636.1 - 0.2 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 DDE_1 PF03184.19 EEA24637.1 - 6.2e-33 113.9 0.0 1.5e-32 112.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA24637.1 - 1.2e-09 38.1 0.1 4.2e-09 36.3 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA24637.1 - 1.2e-05 24.9 0.0 2.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.6 EEA24637.1 - 0.086 13.0 0.1 0.53 10.5 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain DDE_1 PF03184.19 EEA24638.1 - 5.6e-28 97.8 0.0 8.7e-28 97.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA24638.1 - 2e-09 37.3 0.0 7e-09 35.6 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA24638.1 - 0.0004 20.1 0.0 0.001 18.7 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EEA24638.1 - 0.0063 16.3 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_DeoR PF08220.12 EEA24638.1 - 0.073 12.8 0.3 0.31 10.8 0.2 2.2 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain GlnD_UR_UTase PF08335.11 EEA24638.1 - 0.11 12.5 0.6 0.22 11.6 0.6 1.4 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase AAA_18 PF13238.6 EEA24639.1 - 3.1e-24 86.0 0.0 6.9e-24 84.9 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EEA24639.1 - 8.1e-06 26.3 0.0 3.1e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EEA24639.1 - 0.0005 20.5 0.0 0.005 17.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EEA24639.1 - 0.0049 17.0 0.0 0.016 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain ADK PF00406.22 EEA24639.1 - 0.005 16.9 0.0 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 Adenylate kinase AAA_28 PF13521.6 EEA24639.1 - 0.0097 16.2 0.0 0.032 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA24639.1 - 0.013 15.9 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase KTI12 PF08433.10 EEA24639.1 - 0.055 12.9 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 EEA24639.1 - 0.076 12.9 0.2 0.15 11.9 0.1 1.6 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 EEA24639.1 - 0.076 13.0 0.0 0.18 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EEA24639.1 - 0.13 12.5 0.1 0.35 11.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA24640.1 - 3.1e-24 86.0 0.0 6.9e-24 84.9 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EEA24640.1 - 8.1e-06 26.3 0.0 3.1e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EEA24640.1 - 0.0005 20.5 0.0 0.005 17.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EEA24640.1 - 0.0049 17.0 0.0 0.016 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain ADK PF00406.22 EEA24640.1 - 0.005 16.9 0.0 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 Adenylate kinase AAA_28 PF13521.6 EEA24640.1 - 0.0097 16.2 0.0 0.032 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA24640.1 - 0.013 15.9 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase KTI12 PF08433.10 EEA24640.1 - 0.055 12.9 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 EEA24640.1 - 0.076 12.9 0.2 0.15 11.9 0.1 1.6 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 EEA24640.1 - 0.076 13.0 0.0 0.18 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EEA24640.1 - 0.13 12.5 0.1 0.35 11.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain Ham1p_like PF01725.16 EEA24641.1 - 2.1e-58 197.3 0.0 2.3e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF1918 PF08940.11 EEA24641.1 - 0.11 12.2 0.1 0.41 10.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) Glyco_hydro_42 PF02449.15 EEA24641.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Beta-galactosidase Ham1p_like PF01725.16 EEA24642.1 - 9.7e-33 113.7 0.0 1.1e-32 113.5 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF1918 PF08940.11 EEA24642.1 - 0.088 12.5 0.1 0.22 11.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Ham1p_like PF01725.16 EEA24643.1 - 9.7e-33 113.7 0.0 1.1e-32 113.5 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF1918 PF08940.11 EEA24643.1 - 0.088 12.5 0.1 0.22 11.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Ham1p_like PF01725.16 EEA24644.1 - 9.7e-33 113.7 0.0 1.1e-32 113.5 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF1918 PF08940.11 EEA24644.1 - 0.088 12.5 0.1 0.22 11.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Ham1p_like PF01725.16 EEA24645.1 - 9.7e-33 113.7 0.0 1.1e-32 113.5 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF1918 PF08940.11 EEA24645.1 - 0.088 12.5 0.1 0.22 11.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Myosin_head PF00063.21 EEA24646.1 - 3.9e-262 871.4 2.8 3.9e-262 871.4 2.8 1.5 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 EEA24646.1 - 1.5e-26 92.7 2.5 1.5e-26 92.7 2.5 2.9 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 EEA24646.1 - 2.3e-16 58.0 27.0 5.2e-05 22.7 2.0 5.8 5 0 0 5 5 5 4 IQ calmodulin-binding motif Myosin_N PF02736.19 EEA24646.1 - 4e-05 23.4 0.9 0.0001 22.0 0.9 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain GAS PF13851.6 EEA24646.1 - 8.7e-05 22.0 15.2 8.7e-05 22.0 15.2 3.1 3 1 1 4 4 4 1 Growth-arrest specific micro-tubule binding AAA_16 PF13191.6 EEA24646.1 - 0.0021 18.5 0.7 0.013 15.9 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA24646.1 - 0.0057 16.6 0.0 0.021 14.8 0.0 2.0 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EEA24646.1 - 0.01 16.1 0.5 0.041 14.1 0.0 2.3 2 0 0 2 2 1 0 AAA domain ATG16 PF08614.11 EEA24646.1 - 0.036 14.3 30.5 0.48 10.6 30.7 2.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) TMP_2 PF06791.13 EEA24646.1 - 0.12 12.0 0.9 0.27 10.9 0.9 1.5 1 0 0 1 1 1 0 Prophage tail length tape measure protein RNA_helicase PF00910.22 EEA24646.1 - 0.15 12.4 0.1 1 9.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Phage_GP20 PF06810.11 EEA24646.1 - 0.21 11.4 10.6 6.2 6.6 9.9 2.8 1 1 0 1 1 1 0 Phage minor structural protein GP20 KASH_CCD PF14662.6 EEA24646.1 - 1.4 8.7 29.0 0.034 14.0 7.9 2.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 EEA24646.1 - 2.3 8.7 35.5 0.83 10.2 22.8 3.4 2 1 1 3 3 3 0 Apg6 coiled-coil region Baculo_PEP_C PF04513.12 EEA24646.1 - 3.7 7.6 11.6 0.51 10.4 5.1 3.1 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4665 PF15679.5 EEA24646.1 - 4.1 8.1 5.7 4.1 8.1 1.4 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4665) DUF4615 PF15393.6 EEA24646.1 - 6.2 7.4 10.3 90 3.6 10.2 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4615) DegQ PF08181.11 EEA24646.1 - 6.8 6.9 9.6 0.39 10.8 2.0 2.9 2 0 0 2 2 2 0 DegQ (SacQ) family NAP PF00956.18 EEA24647.1 - 3.1e-99 331.5 7.6 3.1e-99 331.5 7.6 1.7 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) P5-ATPase PF12409.8 EEA24648.1 - 1e-36 125.8 0.0 2.2e-36 124.7 0.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EEA24648.1 - 3.1e-31 108.3 0.6 8.1e-31 106.9 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EEA24648.1 - 3.5e-17 63.4 0.1 2.1e-08 34.7 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA24648.1 - 0.0004 20.0 0.0 0.00085 19.0 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EEA24648.1 - 0.0029 17.6 0.0 0.0058 16.7 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA24648.1 - 0.0084 15.9 0.0 3.3 7.4 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase NADH_B2 PF14813.6 EEA24649.1 - 0.0092 15.8 0.2 0.01 15.6 0.2 1.1 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Pkinase PF00069.25 EEA24650.1 - 4.8e-64 216.3 0.0 5.7e-64 216.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24650.1 - 2.5e-29 102.3 0.0 3.4e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA24650.1 - 0.00044 19.7 0.0 0.0015 17.9 0.0 1.7 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EEA24650.1 - 0.0057 15.7 0.0 0.016 14.1 0.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EEA24650.1 - 0.029 13.2 0.0 0.041 12.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EEA24650.1 - 0.083 12.5 0.1 9.1 5.8 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 2-Hacid_dh_C PF02826.19 EEA24651.1 - 2.8e-51 173.4 0.0 5.1e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA24651.1 - 3.1e-37 127.2 0.1 4.7e-37 126.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA24651.1 - 4.9e-05 23.5 0.1 0.00016 21.9 0.1 1.9 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.25 EEA24651.1 - 0.00015 21.5 0.0 0.0004 20.1 0.0 1.8 1 0 0 1 1 1 1 ACT domain IlvN PF07991.12 EEA24651.1 - 0.0002 20.9 0.3 0.014 15.0 0.0 2.7 3 0 0 3 3 3 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 EEA24651.1 - 0.0096 16.0 0.2 0.025 14.6 0.0 1.7 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 EEA24651.1 - 0.036 14.6 0.5 0.41 11.2 0.0 2.5 2 1 0 2 2 2 0 XdhC Rossmann domain tRNA-synt_2b PF00587.25 EEA24652.1 - 7.7e-40 136.8 0.0 1.4e-39 135.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EEA24652.1 - 1.2e-16 60.9 8.9 1.2e-16 60.9 8.9 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain RF-1 PF00472.20 EEA24652.1 - 0.022 14.7 4.4 0.049 13.6 4.4 1.6 1 0 0 1 1 1 0 RF-1 domain Cytochrom_C552 PF02335.15 EEA24652.1 - 0.058 12.3 9.2 0.63 8.9 0.2 2.2 2 0 0 2 2 2 0 Cytochrome c552 Ras PF00071.22 EEA24653.1 - 2e-45 154.3 0.2 2.2e-45 154.1 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA24653.1 - 4.9e-16 59.0 0.1 6.5e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA24653.1 - 5.8e-08 32.4 0.0 6.5e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA24653.1 - 4.3e-05 23.6 0.0 5.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA24653.1 - 6.1e-05 22.7 0.5 0.00092 18.8 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EEA24653.1 - 0.00066 19.2 0.0 0.00097 18.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EEA24653.1 - 0.00066 19.6 0.1 0.11 12.4 0.0 2.1 1 1 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 EEA24653.1 - 0.0074 16.5 0.0 0.015 15.5 0.0 1.5 2 0 0 2 2 2 1 AAA domain FeoB_N PF02421.18 EEA24653.1 - 0.019 14.5 0.0 0.13 11.7 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_14 PF13173.6 EEA24653.1 - 0.035 14.2 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EEA24653.1 - 0.13 11.7 0.1 0.39 10.1 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein WAPL PF07814.13 EEA24654.1 - 6.9e-72 242.3 7.3 1e-71 241.7 7.3 1.3 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin UPRTase PF14681.6 EEA24655.1 - 1.9e-78 262.6 0.0 2.4e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EEA24655.1 - 0.0029 17.2 0.0 0.0039 16.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.13 EEA24655.1 - 0.22 11.5 0.2 0.36 10.8 0.2 1.2 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) Elf1 PF05129.13 EEA24656.1 - 3.8e-29 100.5 0.1 4.8e-29 100.2 0.1 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-Sec23_Sec24 PF04810.15 EEA24656.1 - 0.012 15.6 0.8 0.41 10.7 0.2 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 EEA24656.1 - 0.021 14.2 0.1 0.041 13.3 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain EST1_DNA_bind PF10373.9 EEA24656.1 - 0.099 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain Ribosomal_S3Ae PF01015.18 EEA24657.1 - 4.6e-88 294.1 1.9 5.8e-88 293.8 1.9 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 EEA24657.1 - 0.012 16.2 0.1 0.096 13.2 0.0 2.2 2 0 0 2 2 2 0 Translation initiation factor SUI1 NEMO PF11577.8 EEA24657.1 - 0.14 12.2 0.3 0.84 9.7 0.0 2.2 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO Peptidase_C78 PF07910.13 EEA24658.1 - 6e-67 225.2 0.0 9.5e-67 224.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C78 zf-Di19 PF05605.12 EEA24658.1 - 0.00081 19.6 5.7 0.047 14.0 1.5 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 EEA24658.1 - 0.026 14.1 0.1 0.076 12.6 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger RBDV_coat PF06593.11 EEA24658.1 - 0.19 11.2 0.0 0.85 9.0 0.0 1.8 2 0 0 2 2 2 0 Raspberry bushy dwarf virus coat protein AA_kinase PF00696.28 EEA24659.1 - 3.5e-39 134.8 0.2 5.6e-39 134.2 0.2 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 EEA24659.1 - 1e-13 50.8 1.3 2.6e-11 43.2 0.2 2.6 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 EEA24659.1 - 1e-10 41.1 1.4 3.7e-08 33.0 0.1 3.3 3 0 0 3 3 3 2 ACT domain Forkhead PF00250.18 EEA24660.1 - 1.6e-35 121.2 0.0 2.9e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain G10 PF01125.17 EEA24661.1 - 1e-67 226.5 5.5 1.1e-67 226.3 5.5 1.0 1 0 0 1 1 1 1 G10 protein zf-Tim10_DDP PF02953.15 EEA24662.1 - 2.3e-21 75.2 4.6 2.8e-21 74.9 4.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger GhoS PF11080.8 EEA24662.1 - 0.017 15.1 0.1 0.021 14.8 0.1 1.1 1 0 0 1 1 1 0 Endoribonuclease GhoS Ribosomal_L23eN PF03939.13 EEA24663.1 - 3.2e-24 84.9 7.1 3.2e-24 84.9 7.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EEA24663.1 - 8.2e-16 58.2 1.2 1.3e-15 57.5 1.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 Bmt2 PF11968.8 EEA24664.1 - 3.4e-86 288.6 0.0 4.2e-86 288.3 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Aa_trans PF01490.18 EEA24665.1 - 1e-65 222.1 23.7 1.2e-65 221.9 23.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MerC PF03203.14 EEA24665.1 - 0.023 15.2 5.0 0.023 15.2 5.0 2.8 2 1 1 3 3 3 0 MerC mercury resistance protein Phage_holin_2_3 PF16080.5 EEA24665.1 - 8.3 6.3 9.0 0.48 10.2 0.2 3.2 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Aa_trans PF01490.18 EEA24666.1 - 2.3e-46 158.3 9.7 2.7e-46 158.1 9.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EEA24666.1 - 0.00016 20.9 4.1 0.00022 20.4 4.1 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Phage_holin_2_3 PF16080.5 EEA24666.1 - 5.4 6.8 9.0 0.37 10.6 0.2 3.1 3 0 0 3 3 3 0 Bacteriophage holin family HP1 eRF1_2 PF03464.15 EEA24667.1 - 5e-47 159.6 0.1 8.2e-47 158.9 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EEA24667.1 - 7.1e-39 132.8 0.6 1.6e-38 131.7 0.6 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EEA24667.1 - 9.2e-22 77.4 0.0 1.5e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EEA24667.1 - 8.5e-09 35.8 0.0 1.5e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EEA24667.1 - 4.1e-08 33.6 0.1 6.4e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor eRF1_2 PF03464.15 EEA24668.1 - 5.2e-47 159.5 0.1 8.7e-47 158.8 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EEA24668.1 - 7.6e-39 132.7 0.6 1.7e-38 131.6 0.6 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EEA24668.1 - 9.8e-22 77.3 0.0 1.6e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EEA24668.1 - 9.1e-09 35.7 0.0 1.6e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EEA24668.1 - 4.4e-08 33.5 0.1 6.8e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Sugar_tr PF00083.24 EEA24669.1 - 0.037 12.9 3.3 0.04 12.8 3.3 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter PDT PF00800.18 EEA24670.1 - 2.5e-60 203.4 0.2 3.6e-60 202.9 0.2 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EEA24670.1 - 4.9e-07 29.4 0.0 1.3e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 ACT domain T2SSF PF00482.23 EEA24670.1 - 0.11 12.5 0.8 0.21 11.5 0.4 1.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F MaoC_dehydratas PF01575.19 EEA24671.1 - 0.0003 20.4 0.0 0.00052 19.6 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain DER1 PF04511.15 EEA24672.1 - 3.5e-13 49.9 0.1 4.4e-13 49.6 0.1 1.1 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 EEA24672.1 - 0.0017 18.3 0.0 0.0027 17.7 0.0 1.3 1 0 0 1 1 1 1 Rhomboid family DUF3298 PF11738.8 EEA24672.1 - 0.093 13.8 0.3 0.19 12.8 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3298) DER1 PF04511.15 EEA24673.1 - 6.6e-14 52.3 1.2 7.6e-14 52.1 1.2 1.0 1 0 0 1 1 1 1 Der1-like family DKCLD PF08068.12 EEA24674.1 - 8.8e-34 115.4 0.1 3e-32 110.4 0.1 2.7 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 EEA24674.1 - 2.4e-23 83.1 0.1 1.9e-20 73.7 0.1 3.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EEA24674.1 - 2.6e-23 81.9 1.9 4.6e-23 81.1 1.9 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EEA24674.1 - 7.1e-22 77.2 1.6 1.3e-21 76.4 1.6 1.4 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EEA24674.1 - 0.0055 16.9 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain Med19 PF10278.9 EEA24674.1 - 3.5 7.5 20.5 6.4 6.7 20.5 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RNA_polI_A34 PF08208.11 EEA24674.1 - 9.2 6.3 29.5 15 5.6 29.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CLTH PF10607.9 EEA24675.1 - 4e-35 120.9 0.0 8.3e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EEA24675.1 - 0.0015 18.4 0.0 0.0033 17.3 0.0 1.6 1 0 0 1 1 1 1 LisH DNA_meth_N PF18284.1 EEA24675.1 - 0.081 12.8 0.3 0.39 10.6 0.0 2.3 2 0 0 2 2 2 0 DNA methylase N-terminal domain DMAP1 PF05499.12 EEA24675.1 - 0.18 11.7 6.7 0.08 12.8 2.6 2.4 3 0 0 3 3 3 0 DNA methyltransferase 1-associated protein 1 (DMAP1) COX16 PF14138.6 EEA24675.1 - 0.25 11.9 1.6 0.65 10.6 1.6 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 DUF2203 PF09969.9 EEA24675.1 - 0.91 10.3 5.9 9.6 7.0 2.0 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF2431 PF10354.9 EEA24676.1 - 2.2e-62 210.3 0.2 5.7e-62 208.9 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) Sigma70_ner PF04546.13 EEA24676.1 - 0.48 10.3 10.8 3.1 7.6 1.0 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region E7 PF00527.18 EEA24676.1 - 2 8.7 11.4 5.6 7.2 2.0 2.8 2 0 0 2 2 2 0 E7 protein, Early protein Peroxin-13_N PF04088.13 EEA24676.1 - 9.1 6.6 0.0 9.1 6.6 0.0 3.4 4 1 0 4 4 4 0 Peroxin 13, N-terminal region EamA PF00892.20 EEA24677.1 - 3e-06 27.5 9.7 3e-06 27.5 9.7 2.2 2 0 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 EEA24677.1 - 0.015 14.7 17.2 0.21 10.9 17.2 2.2 1 1 0 1 1 1 0 Triose-phosphate Transporter family UPF0370 PF13980.6 EEA24677.1 - 0.13 12.3 0.2 0.44 10.6 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) Ycf66_N PF07444.11 EEA24677.1 - 0.18 12.0 5.8 0.61 10.3 1.4 3.2 3 0 0 3 3 3 0 Ycf66 protein N-terminus Thioredoxin PF00085.20 EEA24678.1 - 0.00089 19.2 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin SMI1_KNR4 PF09346.10 EEA24679.1 - 2.3e-34 118.7 0.0 6.9e-34 117.1 0.0 1.8 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) PNRC PF15365.6 EEA24680.1 - 1e-08 34.7 8.7 1e-08 34.7 8.7 3.2 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator motif zf-rbx1 PF12678.7 EEA24681.1 - 3.8e-25 87.9 12.8 5.6e-25 87.4 12.8 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EEA24681.1 - 3.6e-17 62.2 10.0 4.7e-17 61.8 10.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EEA24681.1 - 2.8e-06 27.6 14.8 0.0001 22.6 14.8 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA24681.1 - 9.4e-05 22.2 3.7 9.4e-05 22.2 3.7 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA24681.1 - 0.0015 18.3 11.9 0.028 14.3 11.9 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EEA24681.1 - 0.2 11.9 9.1 0.88 9.8 9.2 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 EEA24681.1 - 0.28 11.1 10.6 0.67 9.9 4.3 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EEA24681.1 - 0.64 9.7 14.6 0.11 12.1 4.6 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EEA24681.1 - 0.65 10.1 8.3 2.5 8.2 8.3 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 EEA24681.1 - 1.1 9.1 17.1 99 2.8 17.1 2.5 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 EEA24681.1 - 9.2 6.3 11.4 51 3.9 11.4 2.3 1 1 0 1 1 1 0 zinc-RING finger domain SPC12 PF06645.13 EEA24682.1 - 2.1e-30 104.6 0.7 2.8e-30 104.2 0.7 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) ZYG-11_interact PF05884.12 EEA24682.1 - 0.0023 17.4 0.1 0.0025 17.3 0.1 1.1 1 0 0 1 1 1 1 Interactor of ZYG-11 DUF3040 PF11239.8 EEA24682.1 - 0.066 13.5 0.4 0.11 12.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Es2 PF09751.9 EEA24683.1 - 7.6e-135 451.0 11.1 9.2e-135 450.7 11.1 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 PBD PF00786.28 EEA24684.1 - 0.082 13.3 0.1 0.27 11.6 0.1 1.9 1 0 0 1 1 1 0 P21-Rho-binding domain DUF3533 PF12051.8 EEA24684.1 - 0.13 11.1 0.1 0.24 10.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Mid1 PF12929.7 EEA24685.1 - 4.9e-157 523.5 14.2 5.8e-157 523.2 14.2 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EEA24685.1 - 0.0024 18.5 7.7 0.041 14.5 3.3 2.8 2 1 0 2 2 2 2 Fz domain CorA PF01544.18 EEA24686.1 - 1.5e-40 139.4 0.0 2.2e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Microtub_bind PF13931.6 EEA24686.1 - 0.12 12.8 0.9 0.71 10.3 0.6 2.2 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding GHMP_kinases_N PF00288.26 EEA24687.1 - 8.4e-10 38.8 0.0 2.1e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EEA24687.1 - 9.4e-05 22.7 0.0 0.0002 21.7 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal TPR_2 PF07719.17 EEA24688.1 - 2.7e-30 102.0 30.2 0.0031 17.5 0.1 12.2 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 EEA24688.1 - 1.9e-25 87.6 26.3 8.5e-06 25.4 0.0 11.2 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_8 PF13181.6 EEA24688.1 - 2.5e-20 70.9 20.2 0.0032 17.6 0.2 11.2 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 EEA24688.1 - 1e-19 70.8 26.3 2.1e-05 24.9 0.0 10.9 8 5 3 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24688.1 - 5.4e-14 51.7 30.3 0.15 13.0 0.0 12.7 11 3 2 13 13 12 5 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24688.1 - 3e-13 49.9 23.0 0.0096 16.2 0.2 9.3 7 2 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 EEA24688.1 - 9.7e-13 47.9 18.4 0.11 13.1 0.1 11.5 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24688.1 - 2.6e-12 47.2 28.2 2e-05 25.1 0.1 9.3 10 2 0 10 10 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 EEA24688.1 - 1.2e-09 37.5 19.1 0.003 17.5 0.2 8.4 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 EEA24688.1 - 7.8e-08 32.2 3.8 1 9.9 0.0 7.4 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA24688.1 - 4e-06 26.5 31.8 0.0019 18.0 0.0 9.3 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 EEA24688.1 - 6e-06 25.8 25.0 0.091 12.5 0.1 8.5 9 0 0 9 9 9 3 TPR repeat ANAPC3 PF12895.7 EEA24688.1 - 0.00028 21.0 7.9 1.6 9.0 0.1 6.0 5 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 EEA24688.1 - 0.0052 16.7 8.7 0.42 10.6 0.2 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 EEA24688.1 - 0.0081 16.7 6.7 0.43 11.3 0.6 5.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TOM20_plant PF06552.12 EEA24688.1 - 0.54 10.0 4.8 1.1 9.0 0.1 3.6 3 2 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 Acyltransferase PF01553.21 EEA24689.1 - 3.4e-26 91.5 0.0 5.6e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EEA24689.1 - 2.4e-14 53.2 0.1 5.1e-14 52.1 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus NAD_kinase PF01513.21 EEA24690.1 - 6.9e-50 169.9 0.0 1.4e-49 168.9 0.0 1.4 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EEA24690.1 - 0.0034 17.0 0.0 0.0056 16.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pkinase PF00069.25 EEA24691.1 - 1.1e-67 228.1 0.8 1.1e-66 224.9 0.8 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24691.1 - 5.4e-51 173.4 0.0 9.2e-51 172.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EEA24691.1 - 1.8e-24 85.8 0.4 1.9e-23 82.6 0.0 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain PH_11 PF15413.6 EEA24691.1 - 1e-13 51.6 0.3 2.6e-13 50.3 0.3 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EEA24691.1 - 4.3e-06 27.2 0.1 1.2e-05 25.7 0.1 1.8 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EEA24691.1 - 8.2e-06 25.3 0.0 1.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA24691.1 - 1e-05 24.5 0.2 4.1e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EEA24691.1 - 6.9e-05 21.9 0.3 0.00014 21.0 0.3 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EEA24691.1 - 0.011 14.8 0.1 0.019 14.0 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 KIND PF16474.5 EEA24691.1 - 0.13 12.2 1.7 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain APH PF01636.23 EEA24691.1 - 2.1 8.2 6.2 0.41 10.5 0.3 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family HGTP_anticodon PF03129.20 EEA24693.1 - 2.2e-20 72.6 0.0 2.2e-20 72.6 0.0 3.1 3 1 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EEA24693.1 - 5.6e-09 36.2 0.0 2.7e-08 34.0 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) InPase PF18823.1 EEA24693.1 - 0.072 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Inorganic Pyrophosphatase Brix PF04427.18 EEA24694.1 - 1.6e-23 83.8 0.3 2.5e-23 83.2 0.3 1.3 1 0 0 1 1 1 1 Brix domain Nop14 PF04147.12 EEA24694.1 - 0.11 10.6 18.0 0.15 10.2 18.0 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EEA24694.1 - 0.25 9.4 18.0 0.37 8.8 18.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 EEA24694.1 - 0.26 9.8 7.4 0.36 9.3 7.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 EEA24694.1 - 0.38 10.1 20.7 0.56 9.5 20.7 1.2 1 0 0 1 1 1 0 BUD22 adh_short_C2 PF13561.6 EEA24695.1 - 3.1e-24 85.8 0.0 9e-13 48.3 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA24695.1 - 7.4e-08 32.1 0.0 9.3e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase ABC2_membrane PF01061.24 EEA24696.1 - 4.3e-15 55.7 9.7 3.3e-10 39.7 3.1 2.1 1 1 1 2 2 2 2 ABC-2 type transporter NDT80_PhoG PF05224.12 EEA24697.1 - 2e-37 129.2 0.0 4.3e-37 128.1 0.0 1.6 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Ribosomal_60s PF00428.19 EEA24697.1 - 3.3 8.4 16.7 0.14 12.7 3.2 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Fungal_trans PF04082.18 EEA24698.1 - 0.0011 18.1 0.1 0.0016 17.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pox_A_type_inc PF04508.12 EEA24698.1 - 0.43 10.5 1.6 0.92 9.5 1.6 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Glyco_hydro_3 PF00933.21 EEA24700.1 - 2.2e-72 244.1 0.0 2.9e-72 243.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 EEA24700.1 - 2.7e-05 24.4 0.0 8.1e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Glyco_hydro_3_C PF01915.22 EEA24700.1 - 0.00012 22.2 0.3 0.00023 21.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain SMODS PF18144.1 EEA24700.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Glucosamine_iso PF01182.20 EEA24701.1 - 6.9e-22 78.4 0.0 9.8e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Aldedh PF00171.22 EEA24702.1 - 2.5e-158 527.4 1.5 3.1e-158 527.1 1.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Wtap PF17098.5 EEA24702.1 - 0.0065 16.4 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 WTAP/Mum2p family GMC_oxred_N PF00732.19 EEA24703.1 - 7.1e-47 160.2 0.0 9e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA24703.1 - 1.7e-38 132.4 0.0 2.6e-38 131.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EEA24703.1 - 2.5e-05 24.4 0.1 0.00018 21.6 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA24703.1 - 0.00016 20.9 0.0 0.00022 20.4 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EEA24703.1 - 0.00018 20.8 0.0 0.52 9.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EEA24703.1 - 0.0021 17.4 0.0 0.013 14.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA24703.1 - 0.0024 17.5 0.0 0.0087 15.7 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA24703.1 - 0.03 14.9 0.0 2.3 8.8 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EEA24703.1 - 0.033 13.1 0.0 0.048 12.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Amidohydro_1 PF01979.20 EEA24704.1 - 9.3e-19 67.9 0.0 2.5e-18 66.5 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA24704.1 - 1.8e-12 47.5 0.4 5.9e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family MFS_1 PF07690.16 EEA24705.1 - 1.9e-13 50.1 29.0 2.8e-13 49.5 29.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EEA24705.1 - 2.7e-08 33.7 7.1 2.7e-08 33.7 7.1 2.2 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 LapA_dom PF06305.11 EEA24705.1 - 0.55 10.1 4.8 4.3 7.2 0.0 3.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain AMP-binding PF00501.28 EEA24706.1 - 5.4e-91 305.3 0.0 6.9e-91 304.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA24706.1 - 4.2e-10 40.5 0.1 7.8e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Amidase PF01425.21 EEA24707.1 - 0.0016 17.5 0.2 1.3 7.9 0.0 2.4 2 1 0 2 2 2 2 Amidase Fungal_trans PF04082.18 EEA24708.1 - 1.4e-32 112.8 0.5 2.3e-32 112.1 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24708.1 - 0.0008 19.5 17.2 0.0016 18.5 17.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA24709.1 - 1.4e-32 112.8 0.5 2.3e-32 112.1 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24709.1 - 0.0008 19.5 17.2 0.0016 18.5 17.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EEA24710.1 - 1.5e-11 44.1 0.2 1.5e-09 37.6 0.0 3.0 2 1 0 2 2 2 1 FAD binding domain DAO PF01266.24 EEA24710.1 - 0.01 15.5 0.2 0.032 13.8 0.1 1.8 2 1 0 2 2 2 0 FAD dependent oxidoreductase Fungal_TACC PF12709.7 EEA24711.1 - 3.3e-11 43.5 21.8 9.7e-10 38.8 2.6 4.3 4 0 0 4 4 4 2 Fungal Transforming acidic coiled-coil (TACC) proteins LMP PF04778.12 EEA24711.1 - 0.0067 16.4 0.7 0.0067 16.4 0.7 2.6 2 1 0 2 2 2 1 LMP repeated region QueH PF02677.14 EEA24711.1 - 0.13 12.4 1.2 2.1 8.4 3.0 2.0 2 1 0 2 2 2 0 Epoxyqueuosine reductase QueH Tropomyosin_1 PF12718.7 EEA24711.1 - 0.41 10.8 36.0 0.22 11.7 20.5 3.4 2 1 1 3 3 3 0 Tropomyosin like Pkip-1 PF06878.11 EEA24711.1 - 1.1 9.3 4.3 6.9 6.7 1.5 2.7 2 1 0 2 2 2 0 Pkip-1 protein DUF4407 PF14362.6 EEA24711.1 - 4.6 6.5 28.7 3.1 7.0 11.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) CorA PF01544.18 EEA24711.1 - 8.6 5.6 6.6 0.82 8.9 1.5 1.9 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Pox_A_type_inc PF04508.12 EEA24711.1 - 9.2 6.3 9.8 0.67 9.9 0.1 4.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat HALZ PF02183.18 EEA24711.1 - 9.3 6.6 13.1 1.6 9.1 0.4 4.6 4 1 1 5 5 5 0 Homeobox associated leucine zipper MFS_1 PF07690.16 EEA24712.1 - 1.2e-31 109.9 23.3 1.2e-31 109.9 23.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA24712.1 - 2.2e-10 40.0 3.9 2.2e-10 40.0 3.9 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 EEA24712.1 - 0.5 8.7 6.5 0.92 7.8 4.0 2.0 1 1 0 2 2 2 0 Transmembrane secretion effector MFS_1_like PF12832.7 EEA24712.1 - 2.8 6.7 14.9 0.19 10.6 5.0 2.4 2 0 0 2 2 2 0 MFS_1 like family zf-C3HC4_3 PF13920.6 EEA24713.1 - 2.8 7.9 7.1 1.7 8.6 3.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Peptidase_S49_N PF08496.10 EEA24713.1 - 3.8 7.6 12.7 6.3 6.8 7.9 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Peptidase_S28 PF05577.12 EEA24714.1 - 9e-55 186.2 0.4 2.5e-42 145.2 0.0 2.2 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EEA24714.1 - 0.1 12.1 0.1 0.26 10.7 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family SlyX PF04102.12 EEA24715.1 - 0.0031 18.1 2.5 1.1 9.9 0.5 2.4 2 0 0 2 2 2 2 SlyX End3 PF12761.7 EEA24715.1 - 0.014 15.6 0.1 3.5 7.7 0.1 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 PV-1 PF06637.11 EEA24715.1 - 0.014 14.2 0.1 0.024 13.5 0.1 1.3 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF2046 PF09755.9 EEA24715.1 - 0.021 14.1 0.1 0.19 10.9 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) SOGA PF11365.8 EEA24715.1 - 0.034 15.3 1.6 0.21 12.7 0.2 2.2 2 0 0 2 2 2 0 Protein SOGA FlaC_arch PF05377.11 EEA24715.1 - 0.13 12.7 0.7 0.3 11.5 0.1 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CCDC106 PF15794.5 EEA24715.1 - 0.33 10.6 9.9 3.6 7.3 4.0 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 DivIC PF04977.15 EEA24715.1 - 0.36 10.6 2.2 0.62 9.9 0.1 2.0 2 0 0 2 2 2 0 Septum formation initiator ATG16 PF08614.11 EEA24715.1 - 0.59 10.3 12.2 0.16 12.2 3.5 2.2 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) GreA_GreB_N PF03449.15 EEA24715.1 - 0.89 9.8 3.8 0.62 10.3 1.8 1.7 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal JIP_LZII PF16471.5 EEA24715.1 - 1.8 8.8 4.9 1 9.6 1.6 2.0 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II CENP-F_N PF10481.9 EEA24715.1 - 4.2 6.9 6.1 8.6 5.9 6.1 1.7 1 1 0 1 1 1 0 Cenp-F N-terminal domain Macoilin PF09726.9 EEA24715.1 - 5.5 5.4 5.9 8.3 4.8 5.9 1.2 1 0 0 1 1 1 0 Macoilin family RRM_1 PF00076.22 EEA24716.1 - 9.5e-11 41.4 0.1 3e-10 39.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA24716.1 - 3.2e-07 30.2 0.0 7.5e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF530 PF04409.12 EEA24716.1 - 0.059 11.7 0.1 0.1 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF530) IBN_N PF03810.19 EEA24718.1 - 7.4e-16 57.8 0.1 1e-13 51.0 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 EEA24718.1 - 6.2e-07 28.6 0.1 5.8e-06 25.4 0.0 2.5 2 0 0 2 2 2 1 Cse1 RIX1 PF08167.12 EEA24718.1 - 0.00016 21.4 0.1 0.92 9.2 0.0 3.8 3 1 1 4 4 4 2 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 EEA24718.1 - 0.0069 16.5 0.2 0.099 12.8 0.1 2.7 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EEA24718.1 - 0.0075 16.6 0.9 2 8.8 0.0 3.5 2 1 0 2 2 2 1 HEAT repeats SapB_2 PF03489.17 EEA24718.1 - 0.14 12.3 2.8 1.5 9.0 0.0 3.9 4 0 0 4 4 4 0 Saposin-like type B, region 2 Xpo1 PF08389.12 EEA24718.1 - 0.16 12.0 0.8 6.5 6.8 0.0 3.6 3 0 0 3 3 3 0 Exportin 1-like protein HEAT_EZ PF13513.6 EEA24718.1 - 8.7 7.0 6.6 38 4.9 0.6 4.8 5 2 0 5 5 5 0 HEAT-like repeat DSHCT PF08148.12 EEA24719.1 - 2.5e-52 176.8 0.4 6.8e-52 175.4 0.4 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EEA24719.1 - 6.1e-39 132.9 0.1 6.1e-39 132.9 0.1 1.9 2 0 0 2 2 2 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 EEA24719.1 - 2.6e-19 70.2 0.0 5.1e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 EEA24719.1 - 2.3e-18 66.5 0.0 6.6e-18 65.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA24719.1 - 7.2e-06 26.1 0.0 1.7e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA24719.1 - 7.4e-06 26.3 0.0 2.8e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain RNA_pol_3_Rpc31 PF11705.8 EEA24719.1 - 8 6.6 12.6 26 5.0 12.6 1.9 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2415 PF10313.9 EEA24720.1 - 1.2e-14 54.0 0.1 3.4e-14 52.5 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) HSP70 PF00012.20 EEA24721.1 - 1.4e-265 882.2 16.3 1.6e-265 882.0 16.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA24721.1 - 4.6e-15 55.3 7.3 1.5e-13 50.3 1.2 2.9 3 0 0 3 3 3 2 MreB/Mbl protein FGGY_C PF02782.16 EEA24721.1 - 0.00042 20.1 0.0 0.0013 18.5 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 EEA24721.1 - 0.0069 15.7 1.7 0.12 11.6 0.1 2.7 2 1 1 3 3 3 1 StbA protein Toxin-deaminase PF14424.6 EEA24721.1 - 0.033 14.3 0.7 0.079 13.0 0.0 2.0 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases Big_3_4 PF13754.6 EEA24721.1 - 0.11 12.3 0.0 4.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function TetR_C_25 PF17933.1 EEA24721.1 - 0.13 12.6 0.1 34 4.8 0.0 2.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain eIF3g PF12353.8 EEA24722.1 - 2e-45 154.2 3.4 3e-45 153.7 3.4 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EEA24722.1 - 4.4e-17 61.7 0.0 7.1e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_7 PF18586.1 EEA24722.1 - 0.022 15.1 0.2 0.05 14.0 0.2 1.5 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 RRM_occluded PF16842.5 EEA24722.1 - 0.1 12.5 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif K_channel_TID PF07941.11 EEA24722.1 - 0.31 11.5 8.7 1.2 9.6 8.7 2.0 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain ribosomal_L24 PF17136.4 EEA24722.1 - 2.3 8.7 8.0 0.16 12.4 1.0 2.5 2 1 1 3 3 3 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 NDT80_PhoG PF05224.12 EEA24723.1 - 5.8e-39 134.2 0.3 9.6e-39 133.5 0.3 1.4 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family CBM_4_9 PF02018.17 EEA24724.1 - 2.1e-06 28.1 0.1 3.8e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain AMP-binding PF00501.28 EEA24725.1 - 5.4e-88 295.4 0.0 8.2e-88 294.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA24725.1 - 0.00024 22.0 0.1 0.00083 20.3 0.1 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CdhD PF03599.16 EEA24725.1 - 0.023 13.4 0.0 0.037 12.7 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit AMP-binding PF00501.28 EEA24726.1 - 4.3e-88 295.8 0.0 6.4e-88 295.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA24726.1 - 0.00023 22.1 0.1 0.00075 20.4 0.1 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CdhD PF03599.16 EEA24726.1 - 0.02 13.6 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit Methyltransf_16 PF10294.9 EEA24727.1 - 1.3e-12 47.8 0.0 1.5e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase p450 PF00067.22 EEA24730.1 - 2.7e-44 151.7 0.0 1.4e-37 129.5 0.0 2.7 1 1 2 3 3 3 2 Cytochrome P450 Transp_cyt_pur PF02133.15 EEA24731.1 - 1.3e-41 142.8 41.0 1.6e-41 142.5 41.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Ribosomal_S14 PF00253.21 EEA24732.1 - 2.3e-15 56.1 2.9 2.5e-15 55.9 2.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.6 EEA24732.1 - 0.042 13.8 0.4 0.055 13.4 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) NMO PF03060.15 EEA24733.1 - 5.2e-58 197.0 1.0 7.3e-58 196.5 1.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EEA24733.1 - 3.8e-11 42.6 0.9 8.5e-11 41.4 0.9 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EEA24733.1 - 8.4e-08 31.6 1.8 1.3e-07 31.0 1.8 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EEA24733.1 - 2.6e-06 26.8 0.4 4.3e-06 26.1 0.4 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase DHO_dh PF01180.21 EEA24733.1 - 0.00028 20.2 0.2 0.00044 19.6 0.2 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NanE PF04131.14 EEA24733.1 - 0.1 11.8 0.0 0.25 10.5 0.0 1.7 1 1 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase SPX PF03105.19 EEA24734.1 - 2e-05 24.7 0.6 0.005 16.8 0.0 2.1 2 0 0 2 2 2 2 SPX domain Ank_2 PF12796.7 EEA24735.1 - 5.3e-22 78.2 0.0 9.3e-09 35.8 0.0 3.5 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA24735.1 - 2.8e-16 58.0 0.1 0.0099 16.3 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EEA24735.1 - 1.8e-15 57.1 0.2 0.00017 22.0 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA24735.1 - 3.1e-10 40.0 0.1 0.2 12.1 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EEA24735.1 - 2.9e-09 37.0 0.1 0.16 12.3 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) adh_short PF00106.25 EEA24736.1 - 4e-24 85.1 0.1 5.4e-24 84.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24736.1 - 1.4e-11 44.5 0.0 2e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24736.1 - 5.7e-06 26.4 0.2 1.3e-05 25.2 0.2 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA24736.1 - 0.0044 16.2 0.0 0.0065 15.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_7 PF13241.6 EEA24736.1 - 0.044 14.2 0.1 3.6 8.1 0.1 2.2 2 0 0 2 2 2 0 Putative NAD(P)-binding GATase_6 PF13522.6 EEA24736.1 - 0.091 13.0 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase domain Eno-Rase_NADH_b PF12242.8 EEA24736.1 - 0.15 11.9 0.1 0.31 10.8 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Pterin_bind PF00809.22 EEA24738.1 - 1.8e-77 260.3 0.0 2.4e-77 259.9 0.0 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EEA24738.1 - 1.5e-36 125.3 0.0 3.2e-36 124.2 0.0 1.6 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) LBP_M PF17385.2 EEA24738.1 - 0.088 12.3 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase central domain ArfGap PF01412.18 EEA24739.1 - 1.1e-34 119.0 0.1 1.8e-34 118.3 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ArfGap PF01412.18 EEA24740.1 - 1.1e-34 119.0 0.1 1.8e-34 118.3 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TIM21 PF08294.11 EEA24741.1 - 2.3e-42 144.3 0.0 2.8e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 EEA24741.1 - 1.1e-05 25.1 0.0 3e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 CMD PF02627.20 EEA24742.1 - 0.0049 16.9 0.0 0.0095 16.0 0.0 1.4 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Transcrip_act PF04949.13 EEA24742.1 - 0.14 12.0 0.1 0.33 10.8 0.1 1.5 1 0 0 1 1 1 0 Transcriptional activator MR_MLE_C PF13378.6 EEA24743.1 - 2.3e-56 190.8 0.0 3.3e-56 190.3 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EEA24743.1 - 1.9e-06 28.1 0.0 3.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Peptidase_Prp PF04327.12 EEA24743.1 - 0.047 13.9 0.0 0.099 12.9 0.0 1.5 1 0 0 1 1 1 0 Cysteine protease Prp MAAL_C PF07476.11 EEA24743.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus PWI PF01480.17 EEA24744.1 - 1.5e-16 60.5 1.1 3.5e-16 59.3 1.1 1.7 1 0 0 1 1 1 1 PWI domain DUF4298 PF14131.6 EEA24744.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) PGI PF00342.19 EEA24745.1 - 3.5e-241 800.9 1.2 4.1e-241 800.7 1.2 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Ribosomal_S21 PF01165.20 EEA24747.1 - 1.8e-09 37.2 0.9 1.8e-09 37.2 0.9 1.9 2 0 0 2 2 2 1 Ribosomal protein S21 Dermcidin PF15291.6 EEA24747.1 - 0.041 14.4 1.5 0.12 12.9 1.5 1.8 1 0 0 1 1 1 0 Dermcidin, antibiotic peptide T2SSF PF00482.23 EEA24747.1 - 0.13 12.3 0.3 0.37 10.8 0.2 1.8 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein F Rhodanese PF00581.20 EEA24748.1 - 9.1e-11 42.2 0.0 1.2e-10 41.9 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_28 PF02636.17 EEA24749.1 - 1.4e-79 267.4 0.0 1.8e-79 267.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase NAAA-beta PF15508.6 EEA24751.1 - 2.7e-16 59.6 0.1 5.3e-16 58.7 0.1 1.5 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase GMC_oxred_N PF00732.19 EEA24752.1 - 2.6e-52 178.0 0.0 3.4e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA24752.1 - 2.7e-32 112.3 0.0 4.8e-32 111.5 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EEA24752.1 - 0.0012 19.1 0.1 0.0031 17.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA24752.1 - 0.025 13.7 0.6 0.15 11.1 0.9 2.0 3 0 0 3 3 3 0 FAD binding domain Lycopene_cycl PF05834.12 EEA24752.1 - 0.039 13.0 0.1 0.075 12.1 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EEA24752.1 - 0.064 12.5 0.6 0.13 11.4 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA24752.1 - 0.072 12.3 0.1 0.15 11.3 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 EEA24754.1 - 3.2e-64 216.9 0.0 4.5e-64 216.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24754.1 - 1.3e-25 90.1 0.0 2.3e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA24754.1 - 0.0013 18.1 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA24754.1 - 0.0032 16.8 0.0 0.04 13.2 0.0 2.2 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EEA24754.1 - 0.0059 16.2 0.0 0.0059 16.2 0.0 1.7 2 0 0 2 2 2 1 RIO1 family Haspin_kinase PF12330.8 EEA24754.1 - 0.021 13.8 0.0 0.033 13.1 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EEA24754.1 - 0.16 11.9 0.1 0.16 11.9 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family HMA PF00403.26 EEA24755.1 - 1.4e-13 51.1 0.0 2.5e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EEA24755.1 - 7.3e-09 35.9 0.0 1.1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TPR_1 PF00515.28 EEA24756.1 - 3e-15 55.3 0.6 1.3e-06 27.9 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA24756.1 - 8.8e-15 53.6 1.4 3.2e-05 23.7 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24756.1 - 1.5e-09 38.0 0.1 7e-06 26.2 0.0 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA24756.1 - 1.5e-08 34.2 0.6 0.00015 21.7 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA24756.1 - 5.3e-07 29.2 1.0 0.00033 20.5 0.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA24756.1 - 7.8e-07 28.7 0.8 0.0001 21.9 0.1 3.7 2 1 1 3 3 3 1 TPR repeat TPR_6 PF13174.6 EEA24756.1 - 6.1e-06 26.5 0.0 2.4 9.0 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EEA24756.1 - 0.00028 21.0 0.1 0.21 11.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24756.1 - 0.00055 20.5 0.4 0.12 13.0 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EEA24756.1 - 0.0078 16.1 0.9 3.4 7.7 0.0 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24756.1 - 0.0094 16.7 1.1 0.33 11.9 0.0 3.4 3 1 1 4 4 3 1 Tetratricopeptide repeat PB1 PF00564.24 EEA24756.1 - 0.013 15.4 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 PB1 domain TPR_4 PF07721.14 EEA24756.1 - 0.029 15.0 1.9 69 4.5 0.0 4.4 4 1 0 4 4 3 0 Tetratricopeptide repeat Syntaxin-18_N PF10496.9 EEA24757.1 - 3.8e-14 52.7 0.8 3.8e-14 52.7 0.8 3.2 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 EEA24757.1 - 9.1e-06 25.6 0.4 0.00011 22.1 0.0 2.5 2 0 0 2 2 2 1 SNARE domain LPP PF04728.13 EEA24757.1 - 5.1 7.6 7.1 0.58 10.6 0.1 3.0 4 1 0 4 4 4 0 Lipoprotein leucine-zipper Aminotran_1_2 PF00155.21 EEA24758.1 - 1.9e-82 277.3 0.0 2.2e-82 277.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II RIH_assoc PF08454.11 EEA24759.1 - 0.0041 16.9 0.7 0.061 13.2 0.0 3.1 3 1 0 3 3 3 1 RyR and IP3R Homology associated MSP1_C PF07462.11 EEA24759.1 - 0.059 12.1 0.1 0.093 11.4 0.1 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus NACHT PF05729.12 EEA24759.1 - 0.088 12.7 0.6 0.46 10.4 0.1 2.3 2 0 0 2 2 2 0 NACHT domain RNase_P_Rpp14 PF01900.19 EEA24759.1 - 0.17 12.2 0.4 0.98 9.7 0.1 2.5 3 0 0 3 3 3 0 Rpp14/Pop5 family Alpha_GJ PF03229.13 EEA24759.1 - 8.3 7.0 10.7 24 5.5 9.0 2.3 2 0 0 2 2 2 0 Alphavirus glycoprotein J zf-RING_2 PF13639.6 EEA24760.1 - 1.7e-13 50.7 5.5 3.3e-13 49.8 5.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EEA24760.1 - 8.7e-11 41.4 2.0 8.7e-11 41.4 2.0 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA24760.1 - 5.2e-09 35.8 5.6 1.1e-08 34.8 5.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA24760.1 - 2.4e-08 33.7 3.1 4.6e-08 32.8 3.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA24760.1 - 1.3e-06 28.5 8.3 7.1e-06 26.2 8.3 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EEA24760.1 - 2.4e-05 24.2 2.1 4.8e-05 23.2 2.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA24760.1 - 7.5e-05 22.5 1.7 0.00014 21.7 1.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA24760.1 - 0.00062 19.6 7.1 0.00062 19.6 7.1 2.7 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EEA24760.1 - 0.00072 19.6 2.1 0.0015 18.5 2.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EEA24760.1 - 0.0035 17.1 3.9 0.0064 16.3 3.9 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 EEA24760.1 - 0.007 16.4 6.2 0.007 16.4 6.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING-like PF08746.11 EEA24760.1 - 0.047 14.0 1.5 0.089 13.1 1.5 1.5 1 0 0 1 1 1 0 RING-like domain Zn_ribbon_17 PF17120.5 EEA24760.1 - 0.098 12.3 1.5 0.17 11.5 1.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EEA24760.1 - 0.68 10.1 5.3 1.5 9.1 5.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.6 EEA24760.1 - 0.85 9.6 3.5 1.1 9.2 1.6 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.8 EEA24760.1 - 1.1 9.4 5.3 14 6.0 5.4 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain MS_channel PF00924.18 EEA24761.1 - 5.7e-19 68.5 2.8 9.5e-19 67.8 2.8 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel LRR19-TM PF15176.6 EEA24761.1 - 0.0018 18.2 0.0 0.0058 16.6 0.0 1.9 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain EF-hand_7 PF13499.6 EEA24761.1 - 0.0079 16.6 0.1 0.019 15.4 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EEA24761.1 - 0.0097 15.4 0.1 0.023 14.2 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EEA24761.1 - 0.012 15.5 0.0 0.029 14.3 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 EEA24761.1 - 0.049 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 EF hand Mgm101p PF06420.12 EEA24762.1 - 5.1e-87 289.7 0.0 6.7e-87 289.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 DUF908 PF06012.12 EEA24762.1 - 0.091 12.2 4.0 0.12 11.7 4.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) FSA_C PF10479.9 EEA24762.1 - 0.45 8.6 2.1 0.53 8.4 2.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 EEA24762.1 - 0.85 9.6 21.4 1.5 8.8 21.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Med3 PF11593.8 EEA24762.1 - 1.4 8.1 10.9 1.7 7.7 10.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Med13_C PF06333.12 EEA24762.1 - 1.4 8.1 9.1 1.9 7.7 9.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain CHCH PF06747.13 EEA24763.1 - 7.7e-08 32.3 7.3 1.3e-07 31.6 7.3 1.4 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EEA24763.1 - 0.0017 18.3 0.8 0.14 12.2 0.1 2.4 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Toxin_25 PF08095.11 EEA24763.1 - 0.013 15.4 0.4 0.013 15.4 0.4 2.2 2 1 0 2 2 2 0 Hefutoxin family Cmc1 PF08583.10 EEA24763.1 - 0.026 14.5 5.7 32 4.7 0.3 2.2 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like FAM212 PF15342.6 EEA24763.1 - 0.68 9.8 3.6 0.86 9.4 0.8 2.1 1 1 1 2 2 2 0 FAM212 family BPL_N PF09825.9 EEA24764.1 - 3.2e-150 500.4 0.1 3.9e-150 500.1 0.1 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EEA24764.1 - 3.4e-24 85.2 0.0 8.1e-24 84.0 0.0 1.6 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family TANGO2 PF05742.12 EEA24765.1 - 2.5e-69 234.1 0.0 5.2e-69 233.1 0.0 1.5 1 1 0 1 1 1 1 Transport and Golgi organisation 2 Carb_anhydrase PF00194.21 EEA24766.1 - 1.2e-33 116.7 0.0 2.8e-33 115.5 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase TB2_DP1_HVA22 PF03134.19 EEA24768.1 - 1.2e-23 82.9 5.3 2e-23 82.1 5.3 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family PYST-C1 PF09690.10 EEA24768.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) MIF4G PF02854.19 EEA24769.1 - 7.4e-51 172.8 0.0 1.4e-50 171.9 0.0 1.5 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EEA24769.1 - 4.6e-22 78.0 2.3 1.4e-21 76.4 2.3 1.9 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Usp PF00582.26 EEA24770.1 - 2.6e-22 79.8 0.1 5e-22 78.9 0.1 1.5 1 0 0 1 1 1 1 Universal stress protein family FAD_binding_3 PF01494.19 EEA24771.1 - 7.1e-45 153.8 0.0 9.4e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA24771.1 - 2e-06 27.9 0.1 5.2e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA24771.1 - 9.4e-06 24.6 0.1 3.8e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EEA24771.1 - 1.7e-05 24.6 0.2 0.0064 16.1 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA24771.1 - 2.4e-05 23.7 0.0 9.1e-05 21.8 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA24771.1 - 0.0002 21.9 0.0 0.011 16.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA24771.1 - 0.00042 19.5 0.1 0.001 18.2 0.1 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Amino_oxidase PF01593.24 EEA24771.1 - 0.00044 19.6 0.1 0.069 12.4 0.0 2.4 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EEA24771.1 - 0.0014 18.0 0.0 0.011 15.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA24771.1 - 0.0025 17.0 0.0 0.0041 16.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EEA24771.1 - 0.0026 17.0 0.2 0.0044 16.3 0.2 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 EEA24771.1 - 0.0084 15.2 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EEA24771.1 - 0.024 14.0 0.0 0.049 13.0 0.0 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EEA24771.1 - 0.036 14.1 0.1 0.42 10.6 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 EEA24771.1 - 0.082 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 EEA24771.1 - 0.12 11.2 0.2 0.18 10.7 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase F-box-like PF12937.7 EEA24772.1 - 0.0063 16.4 0.6 0.84 9.6 0.0 3.6 3 0 0 3 3 3 1 F-box-like Dynamin_N PF00350.23 EEA24773.1 - 6.4e-31 107.7 0.1 1.2e-30 106.8 0.1 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EEA24773.1 - 1.7e-18 66.9 0.0 9.8e-18 64.4 0.0 2.1 1 1 0 1 1 1 1 Dynamin central region Fungal_trans_2 PF11951.8 EEA24773.1 - 6.3e-08 31.8 2.2 1.1e-07 31.0 2.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MMR_HSR1 PF01926.23 EEA24773.1 - 0.00033 20.7 0.1 0.0012 18.9 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EEA24773.1 - 0.018 15.2 1.2 0.039 14.1 0.2 2.1 2 0 0 2 2 2 0 Dynamin GTPase effector domain AAA_29 PF13555.6 EEA24773.1 - 0.076 12.8 0.3 0.77 9.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA24773.1 - 0.1 13.0 0.1 0.48 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain TP2 PF01254.18 EEA24773.1 - 0.63 10.6 3.3 0.29 11.7 0.5 1.9 2 0 0 2 2 2 0 Nuclear transition protein 2 DIOX_N PF14226.6 EEA24774.1 - 5.8e-26 91.6 0.0 1e-25 90.8 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA24774.1 - 8e-20 71.2 0.0 1.4e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GBP_repeat PF02526.14 EEA24774.1 - 0.17 11.6 1.0 0.33 10.7 0.1 2.0 2 0 0 2 2 2 0 Glycophorin-binding protein Aldedh PF00171.22 EEA24776.1 - 1.2e-148 495.5 0.4 1.4e-148 495.2 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family S4 PF01479.25 EEA24776.1 - 0.13 12.0 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 S4 domain TMEM154 PF15102.6 EEA24777.1 - 0.043 13.7 0.1 0.043 13.7 0.1 2.4 2 0 0 2 2 2 0 TMEM154 protein family Pro_isomerase PF00160.21 EEA24778.1 - 1.3e-51 175.0 0.0 3.1e-51 173.8 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EEA24778.1 - 1.1e-10 41.9 0.1 0.0011 19.7 0.0 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EEA24778.1 - 7.8e-05 21.8 0.1 0.012 14.6 0.1 3.0 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EEA24778.1 - 0.031 14.6 0.0 1.4 9.2 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Cpn60_TCP1 PF00118.24 EEA24779.1 - 4.1e-143 477.6 13.1 4.6e-143 477.4 13.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Phage_tube PF04985.14 EEA24779.1 - 0.08 12.6 0.0 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Phage tail tube protein FII CRM1_repeat PF18777.1 EEA24779.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat CFEM PF05730.11 EEA24780.1 - 9.1e-10 38.5 8.8 1.9e-09 37.4 8.8 1.5 1 0 0 1 1 1 1 CFEM domain Macoilin PF09726.9 EEA24780.1 - 0.00034 19.3 5.4 0.00047 18.9 5.4 1.3 1 0 0 1 1 1 1 Macoilin family TFIIA PF03153.13 EEA24780.1 - 0.0018 18.3 19.6 0.0027 17.8 19.6 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TMEM132D_C PF15706.5 EEA24780.1 - 0.0021 17.8 0.6 0.026 14.3 0.0 2.4 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term LRRFIP PF09738.9 EEA24780.1 - 0.0051 16.3 3.4 0.0051 16.3 3.4 2.0 2 0 0 2 2 1 1 LRRFIP family DUF5129 PF17173.4 EEA24780.1 - 0.011 14.9 0.1 0.017 14.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) FlxA PF14282.6 EEA24780.1 - 0.012 15.6 33.7 0.012 15.6 33.7 2.8 3 1 0 3 3 1 0 FlxA-like protein Siah-Interact_N PF09032.11 EEA24780.1 - 0.032 14.5 8.5 0.081 13.3 8.5 1.6 1 0 0 1 1 1 0 Siah interacting protein, N terminal SKG6 PF08693.10 EEA24780.1 - 0.076 12.4 7.3 0.27 10.7 7.3 2.0 1 1 0 1 1 1 0 Transmembrane alpha-helix domain 60KD_IMP PF02096.20 EEA24780.1 - 0.24 11.3 8.0 0.43 10.5 8.0 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein DUF4407 PF14362.6 EEA24780.1 - 0.91 8.8 12.6 0.042 13.2 6.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Tmemb_cc2 PF10267.9 EEA24780.1 - 1.3 8.1 11.7 0.2 10.7 1.5 2.1 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Roughex PF06020.11 EEA24780.1 - 2.2 7.3 7.1 3.9 6.5 7.1 1.5 1 0 0 1 1 1 0 Drosophila roughex protein EMP24_GP25L PF01105.24 EEA24780.1 - 2.3 8.2 6.6 4.2 7.3 6.6 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Spc24 PF08286.11 EEA24780.1 - 4.6 7.5 8.4 8.3 6.7 8.4 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 GET2 PF08690.10 EEA24780.1 - 5 6.7 17.3 0.015 14.9 7.5 1.7 2 0 0 2 2 2 0 GET complex subunit GET2 DUF4140 PF13600.6 EEA24780.1 - 6.2 7.3 10.2 0.94 10.0 6.0 1.8 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) OmpH PF03938.14 EEA24780.1 - 7.2 7.0 23.3 11 6.4 23.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3632 PF12311.8 EEA24784.1 - 2e-33 116.3 0.0 2.5e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) CDH-cyt PF16010.5 EEA24785.1 - 3.5e-24 85.5 0.3 3.5e-24 85.5 0.3 1.6 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 EEA24785.1 - 4.7e-09 36.5 13.9 1.3e-08 35.1 13.9 1.8 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DOMON PF03351.17 EEA24785.1 - 1.2e-05 25.5 0.1 3e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 DOMON domain DUF2427 PF10348.9 EEA24785.1 - 0.0029 17.3 7.3 0.0029 17.3 7.3 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF2427) Frag1 PF10277.9 EEA24785.1 - 0.018 14.6 14.3 0.043 13.3 14.2 1.7 1 1 0 1 1 1 0 Frag1/DRAM/Sfk1 family PixA PF12306.8 EEA24785.1 - 0.019 15.1 0.1 0.11 12.6 0.1 2.1 1 1 1 2 2 2 0 Inclusion body protein SOR PF07682.11 EEA24785.1 - 0.043 12.7 0.0 0.067 12.1 0.0 1.2 1 0 0 1 1 1 0 Sulphur oxygenase reductase DUF4079 PF13301.6 EEA24785.1 - 0.087 13.0 12.9 1.5 9.0 2.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF3139 PF11337.8 EEA24785.1 - 0.19 12.4 1.0 6.6 7.5 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) DUF4191 PF13829.6 EEA24785.1 - 0.59 9.4 6.2 0.16 11.3 3.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4191) CobD_Cbib PF03186.13 EEA24785.1 - 0.96 8.6 5.6 3.2 6.9 5.3 2.0 1 1 1 2 2 2 0 CobD/Cbib protein DUF2270 PF10028.9 EEA24785.1 - 1.1 8.8 5.2 20 4.7 0.0 2.4 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2270) DUF1430 PF07242.11 EEA24785.1 - 2.1 8.7 10.8 19 5.6 6.5 2.8 2 1 1 3 3 2 0 Protein of unknown function (DUF1430) DUF202 PF02656.15 EEA24785.1 - 9.4 6.8 20.1 0.97 9.9 3.0 4.0 3 1 1 4 4 3 0 Domain of unknown function (DUF202) FA_desaturase PF00487.24 EEA24786.1 - 4e-25 89.1 25.9 6.3e-25 88.5 25.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EEA24786.1 - 2.2e-09 37.3 0.0 4.6e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Drf_FH1 PF06346.12 EEA24787.1 - 0.011 15.4 32.8 0.011 15.4 32.8 4.9 2 1 3 5 5 5 0 Formin Homology Region 1 ABC_tran PF00005.27 EEA24788.1 - 8.8e-46 155.8 0.0 1.9e-26 93.2 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EEA24788.1 - 4.1e-29 102.1 36.7 2.4e-24 86.4 11.6 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EEA24788.1 - 5.8e-11 42.7 4.8 0.062 13.1 0.0 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA24788.1 - 1.2e-09 38.0 4.7 0.013 15.0 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA24788.1 - 6e-09 36.5 0.2 0.0045 17.4 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA24788.1 - 3.7e-06 27.2 1.2 0.13 12.5 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EEA24788.1 - 8.6e-06 25.8 0.3 0.015 15.3 0.0 3.9 4 0 0 4 4 3 1 AAA domain AAA_29 PF13555.6 EEA24788.1 - 2e-05 24.2 0.7 0.28 10.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.29 EEA24788.1 - 2.9e-05 24.5 0.0 0.21 12.0 0.0 3.9 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EEA24788.1 - 5e-05 23.3 0.2 0.23 11.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase NB-ARC PF00931.22 EEA24788.1 - 5.1e-05 22.6 0.2 0.2 10.8 0.0 2.8 2 1 0 2 2 2 2 NB-ARC domain MMR_HSR1 PF01926.23 EEA24788.1 - 9.1e-05 22.5 0.0 0.17 12.0 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 EEA24788.1 - 0.00015 21.9 0.0 0.72 10.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EEA24788.1 - 0.00026 20.8 0.0 0.08 12.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EEA24788.1 - 0.0013 18.3 0.0 0.43 10.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 EEA24788.1 - 0.0022 17.6 0.0 0.75 9.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EEA24788.1 - 0.0025 17.8 0.2 0.8 9.6 0.0 2.7 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EEA24788.1 - 0.0033 17.8 0.1 8.5 6.8 0.0 3.4 3 0 0 3 3 3 0 RNA helicase AAA_23 PF13476.6 EEA24788.1 - 0.007 16.9 2.8 7.3 7.0 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EEA24788.1 - 0.011 15.5 0.0 4 7.1 0.0 2.8 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EEA24788.1 - 0.014 15.1 0.4 4 7.0 0.2 2.6 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.6 EEA24788.1 - 0.02 15.5 0.0 8.9 6.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EEA24788.1 - 0.021 14.6 0.1 0.16 11.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 EEA24788.1 - 0.023 14.6 0.1 0.37 10.7 0.0 2.6 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 EEA24788.1 - 0.033 13.2 0.0 5.6 5.9 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Septin PF00735.18 EEA24788.1 - 0.043 13.1 0.1 10 5.3 0.0 2.3 2 0 0 2 2 2 0 Septin PRK PF00485.18 EEA24788.1 - 0.048 13.4 0.1 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 EEA24788.1 - 0.057 13.3 1.6 15 5.5 0.0 3.1 3 0 0 3 3 3 0 NTPase AAA_19 PF13245.6 EEA24788.1 - 0.069 13.5 0.0 9.4 6.6 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EEA24788.1 - 0.095 12.7 1.8 25 4.9 0.1 4.0 3 1 1 4 4 3 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EEA24788.1 - 0.1 12.5 1.0 1.1 9.2 0.1 2.9 4 0 0 4 4 3 0 Rad17 P-loop domain Sigma54_activat PF00158.26 EEA24788.1 - 0.11 12.2 0.1 5.7 6.6 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain Roc PF08477.13 EEA24788.1 - 0.14 12.3 0.1 18 5.6 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 EEA24788.1 - 0.17 11.4 1.3 7.4 6.1 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.13 EEA24788.1 - 0.18 10.9 0.3 9.3 5.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF87 PF01935.17 EEA24788.1 - 0.24 11.5 1.3 2 8.5 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_15 PF13175.6 EEA24788.1 - 0.28 10.9 0.8 24 4.5 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 EEA24788.1 - 0.29 11.2 5.8 1.8 8.6 0.1 3.1 4 0 0 4 4 3 0 Dynamin family dNK PF01712.19 EEA24788.1 - 1 9.1 4.1 9.7 6.0 0.0 3.1 3 0 0 3 3 3 0 Deoxynucleoside kinase PGM_PMM_I PF02878.16 EEA24789.1 - 2e-37 128.0 0.1 4.2e-37 126.9 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EEA24789.1 - 3.6e-21 75.7 0.0 8.9e-21 74.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EEA24789.1 - 2.2e-14 53.6 0.0 3.9e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EEA24789.1 - 5.5e-05 23.3 0.0 0.00014 22.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain BHD_3 PF10405.9 EEA24789.1 - 0.0036 17.7 0.0 0.012 15.9 0.0 1.8 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 Pyr_redox_2 PF07992.14 EEA24790.1 - 1.1e-69 234.9 6.0 1.8e-69 234.2 6.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EEA24790.1 - 1.6e-39 134.5 0.3 4.6e-39 133.1 0.0 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EEA24790.1 - 1.5e-23 83.1 9.3 4.6e-22 78.4 0.7 3.5 3 1 1 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA24790.1 - 3.7e-11 43.0 11.6 1.3e-09 38.0 0.3 3.2 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA24790.1 - 8.1e-10 38.4 5.5 1.2e-07 31.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA24790.1 - 8.3e-10 38.3 8.7 6.1e-08 32.1 3.4 2.7 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EEA24790.1 - 2.4e-09 37.3 4.0 5.6e-05 23.3 0.7 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA24790.1 - 6.9e-07 28.7 10.9 7.9e-07 28.5 2.7 2.4 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EEA24790.1 - 7.8e-07 29.0 12.0 0.034 13.7 0.4 4.1 4 0 0 4 4 4 3 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA24790.1 - 1.4e-06 27.3 13.3 0.00071 18.4 1.6 4.1 4 0 0 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 EEA24790.1 - 2.7e-06 26.8 0.7 0.035 13.2 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 EEA24790.1 - 7.2e-06 25.5 8.4 0.0029 16.9 0.7 3.3 3 1 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EEA24790.1 - 1.3e-05 24.5 3.3 0.00026 20.3 0.1 2.4 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EEA24790.1 - 0.0014 17.7 4.2 0.028 13.5 0.1 2.7 3 1 0 3 3 3 1 Lycopene cyclase protein THF_DHG_CYH_C PF02882.19 EEA24790.1 - 0.073 12.4 0.9 0.7 9.2 0.1 2.8 2 1 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FAD_binding_3 PF01494.19 EEA24790.1 - 0.12 11.6 10.2 0.54 9.4 1.1 2.8 2 1 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.6 EEA24790.1 - 0.66 10.4 4.3 0.62 10.5 0.1 2.7 4 0 0 4 4 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 EEA24790.1 - 0.75 8.6 6.0 1.1 8.0 0.6 2.3 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 EEA24790.1 - 4 7.3 9.4 0.074 12.9 1.0 2.4 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FMO-like PF00743.19 EEA24790.1 - 4.1 5.7 4.9 1.2 7.5 0.7 2.0 2 1 0 2 2 2 0 Flavin-binding monooxygenase-like Sugar_tr PF00083.24 EEA24791.1 - 6.7e-86 288.9 22.4 8.1e-86 288.7 22.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24791.1 - 5e-20 71.7 49.7 5.2e-16 58.5 20.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA24791.1 - 0.0013 17.2 5.3 0.0023 16.4 5.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Rick_17kDa_Anti PF05433.15 EEA24791.1 - 0.25 11.2 3.6 0.85 9.5 3.6 1.9 1 0 0 1 1 1 0 Glycine zipper 2TM domain Sugar_tr PF00083.24 EEA24792.1 - 1.4e-81 274.7 19.7 1e-80 271.9 19.7 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24792.1 - 5.1e-23 81.6 29.5 1e-19 70.7 12.8 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA24792.1 - 0.0015 17.1 5.3 0.0025 16.3 5.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Rick_17kDa_Anti PF05433.15 EEA24792.1 - 0.27 11.1 3.6 0.88 9.5 3.6 1.9 1 0 0 1 1 1 0 Glycine zipper 2TM domain Sugar_tr PF00083.24 EEA24793.1 - 4.3e-77 259.9 19.7 5.5e-77 259.5 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24793.1 - 1.2e-18 67.2 46.0 4.2e-16 58.8 20.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA24793.1 - 0.00095 17.7 5.3 0.0017 16.9 5.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Rick_17kDa_Anti PF05433.15 EEA24793.1 - 6.8 6.7 8.7 0.68 9.8 3.6 2.1 2 0 0 2 2 2 0 Glycine zipper 2TM domain Cu_amine_oxid PF01179.20 EEA24794.1 - 3.5e-164 546.6 0.1 4.3e-164 546.3 0.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EEA24794.1 - 1.1e-06 29.0 0.0 2.8e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EEA24794.1 - 0.02 15.1 0.1 0.041 14.1 0.1 1.5 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain Fungal_trans PF04082.18 EEA24797.1 - 5.2e-13 48.6 0.1 1.2e-12 47.5 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24797.1 - 1.1e-05 25.5 9.9 1.9e-05 24.6 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2039 PF10217.9 EEA24797.1 - 0.55 10.6 7.2 1.2 9.6 7.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) TolA_bind_tri PF16331.5 EEA24797.1 - 1.2 9.2 8.2 0.21 11.7 3.5 2.0 2 0 0 2 2 2 0 TolA binding protein trimerisation FMO-like PF00743.19 EEA24798.1 - 1.4e-15 56.7 0.1 1.2e-13 50.4 0.1 2.8 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EEA24798.1 - 2.1e-15 56.7 0.0 9.2e-11 41.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA24798.1 - 1.1e-12 47.9 0.0 9.7e-12 44.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA24798.1 - 2.6e-10 40.0 0.1 2.4e-08 33.5 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EEA24798.1 - 2.8e-08 33.9 0.0 2e-06 27.9 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA24798.1 - 2.2e-05 23.9 0.0 0.00025 20.4 0.1 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EEA24798.1 - 2.9e-05 24.5 0.0 0.11 13.1 0.0 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA24798.1 - 0.00022 20.4 0.0 4.4 6.3 0.1 3.4 4 0 0 4 4 4 2 Lycopene cyclase protein DAO PF01266.24 EEA24798.1 - 0.00051 19.7 1.4 0.042 13.4 0.2 3.5 2 1 2 4 4 4 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EEA24798.1 - 0.0058 16.6 1.6 4.6 7.2 0.0 3.9 4 0 0 4 4 4 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 EEA24798.1 - 0.01 16.2 0.0 0.024 15.1 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 EEA24798.1 - 0.024 13.9 0.2 0.43 9.9 0.1 2.8 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EEA24798.1 - 0.05 12.7 0.0 0.24 10.4 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Shikimate_DH PF01488.20 EEA24798.1 - 0.075 13.1 0.0 0.69 10.0 0.0 2.5 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase NADHdh_A3 PF14987.6 EEA24798.1 - 0.076 13.3 0.2 1 9.7 0.2 2.3 2 0 0 2 2 2 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 GIDA PF01134.22 EEA24798.1 - 0.35 9.9 1.0 2.5 7.1 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 EEA24798.1 - 0.61 8.7 3.4 2.8 6.5 0.2 2.9 4 0 0 4 4 4 0 HI0933-like protein Abhydrolase_3 PF07859.13 EEA24799.1 - 9.6e-20 71.3 0.0 1.2e-19 71.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EEA24799.1 - 2.2e-16 59.7 0.0 1.7e-15 56.8 0.0 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase DUF2974 PF11187.8 EEA24799.1 - 0.0033 17.0 0.0 0.0053 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Peptidase_S9 PF00326.21 EEA24799.1 - 0.066 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Epimerase PF01370.21 EEA24800.1 - 2.5e-16 59.9 0.0 4e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA24800.1 - 5.8e-14 51.8 0.0 7.6e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA24800.1 - 1e-08 35.0 0.1 1e-06 28.4 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EEA24800.1 - 3.2e-08 33.7 0.0 1.2e-07 31.8 0.0 1.8 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA24800.1 - 1.9e-07 30.9 0.0 6e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 NmrA-like family NAD_binding_4 PF07993.12 EEA24800.1 - 2e-06 27.2 0.0 3.1e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein KR PF08659.10 EEA24800.1 - 0.028 14.3 0.2 0.14 12.0 0.2 1.9 2 0 0 2 2 2 0 KR domain DUF3425 PF11905.8 EEA24801.1 - 1.2e-20 73.8 0.0 2.5e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DUF3716 PF12511.8 EEA24801.1 - 5.1 7.2 8.7 3.1 7.9 6.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) T2SSC PF11356.8 EEA24802.1 - 0.0087 16.0 0.7 0.019 14.8 0.7 1.5 1 0 0 1 1 1 1 Type II secretion system protein C MFS_1 PF07690.16 EEA24803.1 - 6.4e-48 163.5 46.3 6.4e-48 163.5 46.3 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA24803.1 - 1e-10 40.7 28.9 2.4e-10 39.5 28.9 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA24803.1 - 3.5e-08 32.7 10.2 3.5e-08 32.7 10.2 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EEA24803.1 - 0.00047 18.6 3.6 0.00047 18.6 3.6 2.6 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Glyco_hydro_16 PF00722.21 EEA24804.1 - 3.3e-40 137.4 5.3 3.3e-40 137.4 5.3 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Pkinase PF00069.25 EEA24806.1 - 4e-73 246.0 0.0 5.4e-73 245.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24806.1 - 3.1e-36 125.0 0.0 4.9e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EEA24806.1 - 9.2e-18 64.8 0.0 9.5e-11 42.2 0.0 2.4 2 0 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 EEA24806.1 - 1.2e-14 54.1 0.0 2.8e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EEA24806.1 - 1.8e-05 24.2 0.0 2.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EEA24806.1 - 0.00038 20.1 0.1 0.00089 18.9 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EEA24806.1 - 0.0072 15.3 0.2 0.013 14.4 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA24806.1 - 0.037 13.4 0.0 0.08 12.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA24806.1 - 0.041 13.8 0.0 0.041 13.8 0.0 2.2 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EEA24806.1 - 0.15 11.0 0.2 0.25 10.3 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase YukC PF10140.9 EEA24806.1 - 0.23 10.3 0.1 0.36 9.6 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF3328 PF11807.8 EEA24807.1 - 2.2e-34 119.2 0.3 2.8e-34 118.8 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EEA24808.1 - 2.3e-34 119.1 0.3 3e-34 118.7 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF1746 PF08508.10 EEA24810.1 - 1.5e-40 138.1 2.3 2e-40 137.7 2.3 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Alg6_Alg8 PF03155.15 EEA24811.1 - 3e-127 425.5 24.7 2.5e-80 270.8 8.5 2.1 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family COX17 PF05051.13 EEA24812.1 - 2.6e-22 78.9 6.9 3.1e-22 78.7 6.9 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EEA24812.1 - 0.021 14.8 3.5 0.32 11.0 0.0 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like LRR_6 PF13516.6 EEA24813.1 - 2.7e-12 45.7 7.3 0.0089 16.0 0.0 8.1 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.7 EEA24813.1 - 0.0013 19.1 14.2 2.5 8.7 0.2 5.6 4 2 1 6 6 6 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EEA24813.1 - 0.012 16.0 2.8 93 4.2 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 EEA24813.1 - 1.2 8.9 12.0 1.2 8.9 0.1 4.9 4 1 0 4 4 4 0 Leucine rich repeat Paf1 PF03985.13 EEA24813.1 - 1.9 7.4 23.3 2.8 6.8 23.3 1.1 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 EEA24813.1 - 5.7 5.0 23.0 7.4 4.6 23.0 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EEA24813.1 - 7.1 5.8 12.8 11 5.3 12.8 1.2 1 0 0 1 1 1 0 NOA36 protein TFIIS_M PF07500.14 EEA24814.1 - 5.7e-32 110.5 0.7 1.2e-31 109.5 0.7 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EEA24814.1 - 1.1e-18 66.8 4.6 1.7e-18 66.2 4.6 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EEA24814.1 - 1.7e-13 50.4 1.8 3.1e-13 49.5 0.4 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Baculo_LEF5_C PF11792.8 EEA24814.1 - 0.068 12.9 0.1 0.068 12.9 0.1 2.0 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain Pectinesterase PF01095.19 EEA24816.1 - 2.4e-25 88.9 3.1 1.1e-20 73.6 3.0 2.1 2 0 0 2 2 2 2 Pectinesterase Hydantoinase_B PF02538.14 EEA24817.1 - 2.7e-207 689.3 0.3 3.4e-207 688.9 0.3 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EEA24817.1 - 2.6e-92 309.2 0.0 4.5e-92 308.4 0.0 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EEA24817.1 - 1.3e-56 191.1 0.0 4.8e-55 186.0 0.0 2.3 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Fungal_trans PF04082.18 EEA24818.1 - 7.3e-27 94.1 0.1 1.2e-26 93.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24818.1 - 3.5e-07 30.2 8.9 5.8e-07 29.5 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EEA24819.1 - 1.8e-08 34.4 11.8 2.9e-08 33.7 11.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EEA24820.1 - 7.3e-85 285.5 26.3 8.2e-85 285.3 26.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA24820.1 - 5.3e-28 98.0 18.8 5.3e-28 98.0 18.8 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily MauE PF07291.11 EEA24820.1 - 0.15 11.8 3.5 0.15 11.8 1.3 2.0 2 0 0 2 2 2 0 Methylamine utilisation protein MauE MIP PF00230.20 EEA24821.1 - 6.7e-37 127.4 5.2 8.8e-37 127.0 5.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein p450 PF00067.22 EEA24822.1 - 7.2e-65 219.5 0.0 8.1e-65 219.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HsbA PF12296.8 EEA24823.1 - 9.8e-18 64.7 0.0 1.7e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A Bromo_TP_like PF17027.5 EEA24823.1 - 0.026 14.7 0.5 6.8 6.9 0.0 2.7 2 1 1 3 3 3 0 Histone-fold protein DUF4085 PF13315.6 EEA24823.1 - 0.13 11.9 0.0 0.37 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4085) TetR_C_14 PF17754.1 EEA24823.1 - 0.21 11.5 0.0 0.91 9.5 0.0 1.8 2 0 0 2 2 2 0 MftR C-terminal domain Fungal_trans PF04082.18 EEA24824.1 - 3e-13 49.4 0.1 7.2e-13 48.2 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24824.1 - 9.4e-07 28.9 14.1 1.6e-06 28.1 14.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_15 PF01793.16 EEA24825.1 - 5e-110 367.8 7.0 6.3e-110 367.4 7.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase SyrA PF11089.8 EEA24825.1 - 0.08 13.0 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Exopolysaccharide production repressor Glyco_transf_15 PF01793.16 EEA24826.1 - 5.5e-105 351.2 7.8 7.1e-105 350.8 7.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase SyrA PF11089.8 EEA24826.1 - 0.062 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Exopolysaccharide production repressor SBP_bac_3 PF00497.20 EEA24826.1 - 0.2 11.1 0.0 3 7.2 0.1 2.2 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 E1-E2_ATPase PF00122.20 EEA24827.1 - 4e-42 143.8 3.9 1.2e-40 139.0 0.1 3.2 3 0 0 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.26 EEA24827.1 - 1.3e-16 61.5 0.0 5.7e-16 59.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA24827.1 - 7e-08 32.0 0.0 2.4e-07 30.4 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EEA24827.1 - 0.0027 17.5 0.2 0.0068 16.2 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA24827.1 - 0.039 14.0 0.0 0.079 13.1 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) GNVR PF13807.6 EEA24827.1 - 0.24 11.4 1.8 0.34 10.9 0.0 2.3 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase HSP70 PF00012.20 EEA24829.1 - 0.46 8.6 1.0 18 3.3 0.1 2.9 2 1 1 3 3 3 0 Hsp70 protein Cytochrom_C_2 PF01322.20 EEA24830.1 - 0.011 16.6 2.4 0.11 13.4 0.0 2.6 1 1 0 2 2 2 0 Cytochrome C' Epimerase PF01370.21 EEA24831.1 - 7.8e-14 51.7 0.7 4.3e-13 49.3 0.5 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA24831.1 - 7.1e-12 45.6 0.1 8.7e-12 45.3 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA24831.1 - 7.2e-10 38.8 0.4 1.1e-09 38.2 0.4 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EEA24831.1 - 3.3e-08 32.9 0.1 4.9e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA24831.1 - 1.7e-07 31.0 0.5 1.1e-06 28.3 0.4 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EEA24831.1 - 1.3e-06 27.7 0.1 0.00032 19.9 0.1 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 EEA24831.1 - 7.6e-06 26.2 0.2 1.3e-05 25.4 0.2 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EEA24831.1 - 2.3e-05 24.6 0.1 4.2e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain adh_short PF00106.25 EEA24831.1 - 3e-05 23.6 0.3 4.7e-05 22.9 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EEA24831.1 - 0.0042 16.3 0.1 0.0063 15.7 0.1 1.3 1 0 0 1 1 1 1 Male sterility protein adh_short_C2 PF13561.6 EEA24831.1 - 0.0051 16.4 0.3 0.0083 15.7 0.3 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24831.1 - 0.0056 16.6 0.2 0.0099 15.8 0.2 1.4 1 0 0 1 1 1 1 KR domain DapB_N PF01113.20 EEA24831.1 - 0.016 15.3 0.3 0.03 14.4 0.3 1.5 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EEA24831.1 - 0.022 15.3 0.1 0.04 14.5 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Amidoligase_2 PF12224.8 EEA24832.1 - 2e-11 44.1 0.0 4.4e-11 42.9 0.0 1.6 1 1 0 1 1 1 1 Putative amidoligase enzyme Glyco_hydro_cc PF11790.8 EEA24834.1 - 4.7e-59 199.8 0.9 5.7e-59 199.6 0.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core JmjN PF02375.17 EEA24834.1 - 0.026 14.5 0.1 0.055 13.4 0.1 1.5 1 0 0 1 1 1 0 jmjN domain Fungal_trans_2 PF11951.8 EEA24835.1 - 4.6e-09 35.6 0.4 6.9e-09 35.0 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24835.1 - 1.8e-06 27.9 12.0 3.8e-06 26.9 12.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EEA24836.1 - 6.5e-41 140.6 0.5 8e-41 140.2 0.5 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ail_Lom PF06316.11 EEA24836.1 - 0.08 12.7 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Enterobacterial Ail/Lom protein AMP-binding PF00501.28 EEA24838.1 - 1.5e-28 99.5 0.0 3.9e-28 98.2 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme Lactamase_B PF00753.27 EEA24839.1 - 3.6e-07 30.4 0.1 1.2e-06 28.7 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA24839.1 - 3.8e-06 26.6 0.1 8e-06 25.5 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EEA24839.1 - 0.01 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain ABC1 PF03109.16 EEA24840.1 - 4e-22 78.6 0.1 3.6e-21 75.5 0.0 2.3 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 EEA24840.1 - 0.029 14.3 0.3 0.14 12.1 0.3 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family AMP-binding PF00501.28 EEA24841.1 - 1.9e-84 283.7 0.0 3.1e-84 283.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 EEA24841.1 - 1.1e-67 228.3 0.0 1.9e-67 227.5 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Condensation PF00668.20 EEA24841.1 - 1.4e-60 205.3 0.1 2.3e-60 204.6 0.1 1.2 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 EEA24841.1 - 9.4e-49 165.8 0.0 4.2e-48 163.6 0.0 2.2 3 0 0 3 3 2 1 KR domain PS-DH PF14765.6 EEA24841.1 - 4e-45 154.3 0.0 7e-45 153.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EEA24841.1 - 2e-44 152.4 0.0 3.9e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA24841.1 - 1.7e-29 102.2 0.0 8.2e-29 100.0 0.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EEA24841.1 - 1.3e-22 80.4 0.0 1e-21 77.5 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EEA24841.1 - 1.5e-19 70.1 0.1 2.9e-09 37.1 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site NAD_binding_4 PF07993.12 EEA24841.1 - 5.5e-18 65.1 0.0 1.9e-17 63.3 0.0 2.0 2 1 0 2 2 2 1 Male sterility protein KAsynt_C_assoc PF16197.5 EEA24841.1 - 8e-13 48.8 0.0 2.3e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 EEA24841.1 - 1.6e-12 47.6 0.0 3.3e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA24841.1 - 8e-12 45.7 0.0 3e-11 43.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA24841.1 - 2.7e-10 40.7 0.0 7.6e-10 39.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EEA24841.1 - 2.2e-08 33.8 0.0 7.1e-08 32.1 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_31 PF13847.6 EEA24841.1 - 3.6e-08 33.3 0.0 1.1e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 EEA24841.1 - 3.4e-06 26.7 0.0 7.5e-05 22.3 0.0 2.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Thiolase_N PF00108.23 EEA24841.1 - 3.4e-05 23.3 0.2 0.00025 20.5 0.0 2.3 2 0 0 2 2 2 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EEA24841.1 - 0.00018 20.9 0.0 0.00035 20.0 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family AMP-binding_C PF13193.6 EEA24841.1 - 0.013 16.5 0.0 0.046 14.7 0.0 2.1 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain ACP_syn_III PF08545.10 EEA24841.1 - 0.039 13.8 0.6 0.19 11.6 0.5 2.2 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_24 PF13578.6 EEA24841.1 - 0.04 14.9 0.0 0.29 12.2 0.0 2.6 2 0 0 2 2 1 0 Methyltransferase domain MFS_1 PF07690.16 EEA24842.1 - 1.7e-50 171.9 20.9 1.7e-50 171.9 20.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA24842.1 - 1e-13 51.0 0.2 1e-13 51.0 0.2 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EEA24842.1 - 7.8e-05 21.3 0.9 7.8e-05 21.3 0.9 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Cyd_oper_YbgE PF09600.10 EEA24842.1 - 0.05 14.0 0.5 0.05 14.0 0.5 2.3 2 0 0 2 2 2 0 Cyd operon protein YbgE (Cyd_oper_YbgE) MFS_3 PF05977.13 EEA24842.1 - 0.097 11.0 6.0 0.93 7.8 6.0 2.1 1 1 0 1 1 1 0 Transmembrane secretion effector COX2-transmemb PF09125.10 EEA24842.1 - 0.14 12.0 0.0 0.73 9.7 0.0 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane p450 PF00067.22 EEA24843.1 - 3.2e-54 184.4 0.0 3.9e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EEA24844.1 - 1.4e-69 235.0 0.0 1.8e-69 234.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Myb_DNA-binding PF00249.31 EEA24845.1 - 5.9e-33 112.8 13.7 7.1e-12 45.3 1.1 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA24845.1 - 9.2e-26 89.9 6.7 4.7e-13 49.2 0.5 3.3 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA24845.1 - 5.2e-07 29.5 0.4 5.5e-06 26.2 0.0 2.3 2 0 0 2 2 2 1 Myb DNA-binding like SANT_DAMP1_like PF16282.5 EEA24845.1 - 0.0011 19.1 0.2 0.0043 17.2 0.0 2.0 1 1 0 2 2 2 1 SANT/Myb-like domain of DAMP1 MADF_DNA_bdg PF10545.9 EEA24845.1 - 0.082 13.2 6.2 1.6 9.1 0.3 3.2 2 1 1 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like adh_short_C2 PF13561.6 EEA24846.1 - 2.8e-60 203.8 0.6 3.3e-60 203.5 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA24846.1 - 1.8e-43 148.3 0.5 2.4e-43 147.9 0.2 1.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA24846.1 - 3.4e-10 40.1 0.4 5.1e-10 39.5 0.4 1.2 1 0 0 1 1 1 1 KR domain Goodbye PF17109.5 EEA24847.1 - 5.3e-39 133.4 0.0 4.2e-38 130.5 0.0 2.6 3 0 0 3 3 3 1 fungal STAND N-terminal Goodbye domain NACHT PF05729.12 EEA24847.1 - 2e-07 31.1 0.1 9.2e-07 28.9 0.0 2.2 3 0 0 3 3 3 1 NACHT domain AAA_16 PF13191.6 EEA24847.1 - 5.6e-06 26.8 0.0 5.5e-05 23.6 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EEA24847.1 - 5.8e-05 23.4 0.0 0.00033 20.9 0.0 2.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EEA24847.1 - 0.0075 16.6 0.0 0.021 15.2 0.0 1.8 1 0 0 1 1 1 1 RNA helicase TPR_2 PF07719.17 EEA24847.1 - 0.0077 16.3 4.2 1.2 9.5 1.4 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_5 PF07728.14 EEA24847.1 - 0.025 14.6 0.0 0.38 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EEA24847.1 - 0.16 12.4 0.0 0.91 10.0 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TPR_7 PF13176.6 EEA24847.1 - 0.18 11.9 0.3 78 3.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24847.1 - 3.4 8.0 6.0 4.4 7.7 0.3 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat Thymosin PF01290.20 EEA24850.1 - 0.062 13.0 0.1 0.2 11.4 0.1 1.9 1 0 0 1 1 1 0 Thymosin beta-4 family PAPS_reduct PF01507.19 EEA24851.1 - 3e-28 99.0 0.0 6.6e-19 68.6 0.0 2.3 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family aGPT-Pplase3 PF18746.1 EEA24851.1 - 0.005 16.2 0.6 1.3 8.3 0.1 2.1 2 0 0 2 2 2 2 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 PAPS_reduct PF01507.19 EEA24852.1 - 1.2e-28 100.3 0.0 3.5e-19 69.5 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family SNARE PF05739.19 EEA24853.1 - 1.3e-13 50.7 0.6 2.2e-13 50.0 0.1 1.7 2 0 0 2 2 2 1 SNARE domain Syntaxin-5_N PF11416.8 EEA24853.1 - 2.3e-10 39.4 0.4 4.8e-10 38.4 0.4 1.6 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 EEA24853.1 - 0.00026 20.8 4.5 0.0024 17.6 0.1 2.7 2 1 0 2 2 2 1 Syntaxin KxDL PF10241.9 EEA24853.1 - 0.00052 20.2 3.6 0.18 12.1 0.1 3.2 4 0 0 4 4 4 2 Uncharacterized conserved protein Snapin_Pallidin PF14712.6 EEA24853.1 - 0.027 14.9 0.8 9.7 6.7 0.0 3.2 3 0 0 3 3 3 0 Snapin/Pallidin FlxA PF14282.6 EEA24853.1 - 0.04 13.9 1.0 0.04 13.9 1.0 2.5 3 2 0 3 3 3 0 FlxA-like protein Syntaxin-18_N PF10496.9 EEA24853.1 - 0.053 13.8 1.4 0.48 10.7 0.0 2.7 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus NPV_P10 PF05531.12 EEA24853.1 - 0.083 13.4 3.0 15 6.1 0.1 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4988 PF16378.5 EEA24853.1 - 0.089 12.5 5.3 8.7 6.0 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function MCPsignal PF00015.21 EEA24853.1 - 1.4 8.7 7.1 0.28 11.0 0.6 2.6 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SUR7 PF06687.12 EEA24856.1 - 2.4e-28 99.2 10.3 2.4e-28 99.2 10.3 1.4 2 0 0 2 2 2 1 SUR7/PalI family SCIMP PF15050.6 EEA24856.1 - 0.021 15.3 0.2 0.064 13.7 0.0 1.9 2 0 0 2 2 2 0 SCIMP protein Pox_P21 PF05313.12 EEA24856.1 - 0.064 12.8 1.5 0.12 12.0 1.5 1.3 1 0 0 1 1 1 0 Poxvirus P21 membrane protein DUF2298 PF10060.9 EEA24856.1 - 0.12 11.1 4.1 0.19 10.4 4.1 1.2 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) DUF4381 PF14316.6 EEA24856.1 - 0.38 11.0 3.5 0.18 12.1 0.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4381) DUF3043 PF11241.8 EEA24856.1 - 0.7 9.9 1.8 1.3 9.0 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) adh_short_C2 PF13561.6 EEA24857.1 - 8.7e-64 215.3 0.1 1e-63 215.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA24857.1 - 1.1e-42 145.7 0.0 1.3e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA24857.1 - 8.4e-15 55.1 0.0 1.2e-14 54.7 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EEA24858.1 - 9.7e-38 129.6 0.0 1.5e-37 128.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24858.1 - 2.8e-27 95.8 0.0 4e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24858.1 - 1.3e-08 35.0 0.1 4.8e-07 29.8 0.1 2.2 1 1 0 1 1 1 1 KR domain UPF0146 PF03686.13 EEA24858.1 - 0.00031 20.6 0.0 0.00094 19.1 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0146) Epimerase PF01370.21 EEA24858.1 - 0.00058 19.4 0.0 0.00091 18.7 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Vut_1 PF02592.15 EEA24858.1 - 0.0076 16.6 0.3 0.013 15.9 0.3 1.3 1 0 0 1 1 1 1 Putative vitamin uptake transporter 2-Hacid_dh_C PF02826.19 EEA24858.1 - 0.073 12.4 0.0 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Abhydrolase_6 PF12697.7 EEA24859.1 - 2e-08 35.1 0.0 2.5e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA24859.1 - 0.0025 17.1 0.1 0.045 13.0 0.1 2.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DAO PF01266.24 EEA24860.1 - 1.3e-26 94.0 0.1 1.6e-26 93.7 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EEA24860.1 - 0.0044 17.0 0.0 0.019 15.0 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EEA24860.1 - 0.081 13.2 0.1 0.28 11.4 0.1 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA24860.1 - 0.11 11.7 0.0 0.44 9.7 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA24860.1 - 0.16 11.2 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family MFS_1 PF07690.16 EEA24861.1 - 1.5e-39 136.0 49.7 1.3e-37 129.6 49.7 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Pyr_redox_3 PF13738.6 EEA24862.1 - 1.1e-18 67.5 0.0 6.8e-16 58.4 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA24862.1 - 3e-18 66.1 0.0 1.8e-13 50.4 0.0 2.9 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EEA24862.1 - 4.9e-15 54.9 0.0 6.9e-12 44.6 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EEA24862.1 - 3.6e-11 42.8 0.0 2.3e-07 30.3 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EEA24862.1 - 3.8e-09 37.0 0.1 0.00023 21.7 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA24862.1 - 1.2e-07 31.3 0.0 1.6e-05 24.3 0.1 2.9 3 0 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 EEA24862.1 - 8.7e-07 29.1 0.0 8.5e-06 25.9 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 EEA24862.1 - 6.4e-06 25.6 0.0 0.0019 17.6 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 EEA24862.1 - 1.4e-05 24.8 0.0 0.0031 17.2 0.1 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EEA24862.1 - 8.7e-05 22.6 0.0 0.41 10.7 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EEA24862.1 - 0.0001 21.5 0.5 0.0019 17.4 0.2 2.6 2 1 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 EEA24862.1 - 0.00023 21.1 0.1 0.4 10.6 0.0 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 EEA24862.1 - 0.00027 20.6 0.4 0.056 13.0 0.1 2.4 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain HI0933_like PF03486.14 EEA24862.1 - 0.0004 19.2 0.1 0.001 17.9 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein TrkA_N PF02254.18 EEA24862.1 - 0.00047 20.4 0.1 0.039 14.2 0.0 2.6 2 0 0 2 2 2 1 TrkA-N domain GIDA PF01134.22 EEA24862.1 - 0.00085 18.5 0.7 0.035 13.2 0.0 2.8 3 0 0 3 3 3 1 Glucose inhibited division protein A ApbA PF02558.16 EEA24862.1 - 0.005 16.5 0.0 0.3 10.7 0.0 2.4 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 EEA24862.1 - 0.0064 15.8 0.0 0.017 14.3 0.0 1.7 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EEA24862.1 - 0.0098 15.0 0.0 0.048 12.7 0.0 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EEA24862.1 - 0.022 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EEA24862.1 - 0.025 14.0 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EEA24862.1 - 0.033 14.6 0.0 8.5 6.9 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_9 PF13454.6 EEA24862.1 - 0.059 13.4 0.2 4.3 7.3 0.1 3.0 2 1 1 3 3 3 0 FAD-NAD(P)-binding XdhC_C PF13478.6 EEA24862.1 - 0.1 13.1 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain SnoaL_2 PF12680.7 EEA24862.1 - 0.14 12.8 0.0 0.43 11.2 0.0 1.9 1 0 0 1 1 1 0 SnoaL-like domain NAD_Gly3P_dh_N PF01210.23 EEA24862.1 - 0.14 12.1 0.2 22 5.0 0.0 2.7 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF1479 PF07350.12 EEA24863.1 - 5.8e-165 549.1 0.0 6.7e-165 548.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) UCH PF00443.29 EEA24863.1 - 0.058 12.9 0.0 0.078 12.5 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DUF1479 PF07350.12 EEA24864.1 - 2.9e-127 424.9 0.0 3.6e-127 424.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) UCH PF00443.29 EEA24864.1 - 0.039 13.4 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Pkinase PF00069.25 EEA24865.1 - 8e-17 61.5 0.0 5.5e-16 58.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24865.1 - 0.00083 18.7 0.0 0.011 15.0 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase FAD_binding_4 PF01565.23 EEA24866.1 - 6.8e-19 68.0 0.2 1.3e-18 67.1 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA24866.1 - 5.4e-07 29.6 0.1 1.4e-06 28.3 0.1 1.8 1 0 0 1 1 1 1 Berberine and berberine like FAD-oxidase_C PF02913.19 EEA24866.1 - 0.032 13.8 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain Cytokin-bind PF09265.10 EEA24866.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding AMP-binding PF00501.28 EEA24867.1 - 5.7e-13 48.2 0.0 8.5e-13 47.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme His_Phos_1 PF00300.22 EEA24868.1 - 0.055 13.1 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) Sugar_tr PF00083.24 EEA24869.1 - 1e-40 140.0 22.1 1.7e-28 99.7 0.3 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EEA24869.1 - 7.5e-16 58.0 32.8 1.4e-15 57.1 29.7 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EEA24869.1 - 0.041 12.2 2.0 0.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family VirE2 PF07229.12 EEA24869.1 - 8.4 4.9 5.9 2.3 6.7 1.1 1.9 1 1 1 2 2 2 0 VirE2 ArAE_2_N PF10337.9 EEA24870.1 - 0.18 10.8 1.3 0.4 9.7 1.3 1.5 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal HisG PF01634.18 EEA24871.1 - 3.1e-55 186.5 0.3 5.3e-55 185.7 0.3 1.4 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EEA24871.1 - 3.4e-29 100.8 1.1 8e-29 99.6 1.1 1.7 1 0 0 1 1 1 1 HisG, C-terminal domain DUF1697 PF08002.11 EEA24871.1 - 0.043 14.3 0.1 0.069 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) adh_short PF00106.25 EEA24872.1 - 4.8e-22 78.4 0.3 2.4e-20 72.9 0.1 2.3 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24872.1 - 4.8e-19 68.8 0.4 1.6e-12 47.5 0.1 2.7 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24872.1 - 7.3e-06 26.0 0.0 1.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 EEA24872.1 - 0.0035 17.3 0.0 0.0067 16.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Polysacc_synt_2 PF02719.15 EEA24872.1 - 0.015 14.5 0.1 0.023 13.9 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Bact_lectin PF18483.1 EEA24872.1 - 0.053 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial lectin ADH_N_2 PF16884.5 EEA24873.1 - 1.4e-24 86.0 0.0 2.7e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EEA24873.1 - 1.4e-20 73.6 0.0 2.3e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA24873.1 - 3e-06 28.3 0.0 7.5e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EEA24874.1 - 1.4e-24 86.0 0.0 2.7e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EEA24874.1 - 1.4e-20 73.6 0.0 2.3e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA24874.1 - 3e-06 28.3 0.0 7.5e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Hydrolase_4 PF12146.8 EEA24877.1 - 0.02 14.2 0.0 0.039 13.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA24877.1 - 0.023 15.3 0.0 0.042 14.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.14 EEA24877.1 - 0.087 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Peptidase_S9 PF00326.21 EEA24877.1 - 0.13 11.7 0.2 0.45 9.9 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family LCAT PF02450.15 EEA24877.1 - 0.14 11.2 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.20 EEA24877.1 - 0.17 11.5 1.0 0.67 9.5 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF2235 PF09994.9 EEA24878.1 - 2.8e-76 256.6 0.0 3.6e-76 256.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Fungal_trans PF04082.18 EEA24879.1 - 2.8e-07 29.8 0.0 5.2e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24879.1 - 0.025 14.7 3.6 0.06 13.5 3.6 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_6 PF12697.7 EEA24880.1 - 2.3e-06 28.4 0.0 4e-06 27.6 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA24880.1 - 0.0018 18.0 0.2 0.004 16.8 0.2 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EEA24880.1 - 0.015 15.4 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 Thioesterase domain Hydrolase_4 PF12146.8 EEA24880.1 - 0.059 12.6 0.0 0.097 11.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 MutS_V PF00488.21 EEA24883.1 - 6.4e-74 248.1 0.1 1.5e-73 246.9 0.1 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EEA24883.1 - 1.9e-38 132.6 2.3 4.7e-38 131.3 2.3 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EEA24883.1 - 1.4e-29 102.6 0.0 3.5e-29 101.3 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EEA24883.1 - 1.2e-08 35.3 0.0 5.7e-08 33.1 0.0 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EEA24883.1 - 0.0012 19.1 0.5 0.046 14.1 0.0 3.3 3 0 0 3 3 3 1 MutS family domain IV DUF4911 PF16256.5 EEA24883.1 - 0.009 16.0 0.0 0.16 11.9 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4911) zf-C2H2_jaz PF12171.8 EEA24884.1 - 0.053 13.8 0.2 0.15 12.4 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-SCNM1 PF15803.5 EEA24884.1 - 0.35 10.5 1.6 0.84 9.3 0.6 2.1 2 0 0 2 2 2 0 Zinc-finger of sodium channel modifier 1 Prenyltrans PF00432.21 EEA24885.1 - 4.3e-54 179.9 5.4 4.8e-11 42.2 0.0 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EEA24885.1 - 0.0062 15.7 0.0 0.052 12.6 0.0 2.4 1 1 1 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EEA24885.1 - 0.0096 15.1 0.0 8.4 5.4 0.0 3.4 2 1 2 4 4 4 1 Squalene-hopene cyclase N-terminal domain DHOR PF06537.11 EEA24885.1 - 0.18 10.4 0.0 0.27 9.8 0.0 1.2 1 0 0 1 1 1 0 Di-haem oxidoreductase, putative peroxidase Methyltransf_23 PF13489.6 EEA24886.1 - 1.9e-15 57.1 0.0 2.7e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA24886.1 - 1.4e-12 48.0 0.0 2.9e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA24886.1 - 2.6e-10 40.9 0.0 4.2e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA24886.1 - 1.3e-09 38.6 0.0 2.3e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA24886.1 - 1.1e-08 35.1 0.0 1.3e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA24886.1 - 0.00075 18.9 0.0 0.00085 18.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EEA24886.1 - 0.097 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) RhoGAP PF00620.27 EEA24887.1 - 1.7e-29 102.7 0.0 2.7e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain adh_short PF00106.25 EEA24888.1 - 7.2e-82 273.6 8.4 7.1e-44 149.6 0.6 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24888.1 - 2.8e-66 223.4 2.7 1.1e-35 123.3 0.2 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EEA24888.1 - 1e-31 109.1 0.0 1.8e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EEA24888.1 - 1.1e-26 93.9 2.7 1.6e-12 47.7 0.3 2.4 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 EEA24888.1 - 8.5e-05 21.9 1.2 0.00043 19.6 0.2 2.5 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PglL_A PF15864.5 EEA24888.1 - 2.2 8.1 6.7 10 6.0 1.0 2.4 2 0 0 2 2 2 0 Protein glycosylation ligase AAA_16 PF13191.6 EEA24889.1 - 0.018 15.4 0.0 0.052 13.9 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EEA24889.1 - 0.11 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cas_St_Csn2 PF16813.5 EEA24889.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Csn2 subfamily St Ribosomal_L30_N PF08079.12 EEA24890.1 - 2.4e-27 95.0 16.9 3.7e-27 94.4 16.9 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EEA24890.1 - 3.6e-17 62.0 1.3 3.6e-17 62.0 1.3 1.8 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e EAP30 PF04157.16 EEA24891.1 - 7.9e-73 244.6 0.0 9e-73 244.4 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family eIF-3c_N PF05470.12 EEA24892.1 - 2.3e-175 584.3 18.9 8.9e-142 473.4 0.8 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EEA24892.1 - 9.9e-14 51.7 3.7 5.5e-13 49.3 0.1 3.4 3 1 0 3 3 3 1 PCI domain DUF1385 PF07136.11 EEA24892.1 - 0.014 14.7 0.0 0.063 12.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) CDC45 PF02724.14 EEA24892.1 - 5.2 5.2 18.5 8.3 4.6 18.5 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF3713 PF12506.8 EEA24892.1 - 7.7 6.9 8.8 5.5 7.3 2.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3713) Pkinase PF00069.25 EEA24893.1 - 9.8e-51 172.6 0.3 7.2e-50 169.8 0.3 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA24893.1 - 1.8e-23 83.2 0.0 3.9e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA24893.1 - 0.0004 20.4 0.1 0.0004 20.4 0.1 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 EEA24893.1 - 0.0032 17.1 0.4 0.017 14.8 0.4 2.0 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EEA24893.1 - 0.12 12.0 3.4 0.36 10.4 0.2 2.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase SNF2_N PF00176.23 EEA24894.1 - 1.1e-66 225.0 0.0 2.2e-66 224.0 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA24894.1 - 4.2e-18 65.7 0.0 1.4e-17 64.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA24894.1 - 3.5e-08 33.6 0.0 2e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Baculo_F PF12259.8 EEA24894.1 - 0.0049 15.4 2.8 0.0077 14.8 2.8 1.2 1 0 0 1 1 1 1 Baculovirus F protein TFIIF_beta PF02270.15 EEA24894.1 - 0.01 15.9 0.0 0.031 14.4 0.0 1.8 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain IMS_C PF11799.8 EEA24894.1 - 0.053 14.2 0.1 0.91 10.2 0.0 2.9 3 0 0 3 3 3 0 impB/mucB/samB family C-terminal domain FtsL PF04999.13 EEA24894.1 - 0.7 9.9 3.3 1.9 8.5 3.3 1.7 1 0 0 1 1 1 0 Cell division protein FtsL AAA_11 PF13086.6 EEA24894.1 - 0.8 9.4 0.0 0.8 9.4 0.0 4.0 3 1 0 3 3 3 0 AAA domain Med27 PF11571.8 EEA24897.1 - 2.6e-16 59.8 0.0 5.3e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit 27 NAD_binding_1 PF00175.21 EEA24898.1 - 1.2e-12 48.4 0.0 2.2e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Globin PF00042.22 EEA24898.1 - 4.9e-10 40.0 0.1 1.1e-09 38.8 0.0 1.7 2 0 0 2 2 2 1 Globin NAD_binding_6 PF08030.12 EEA24898.1 - 2.1e-05 24.7 0.0 4.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 EEA24898.1 - 6.8e-05 23.2 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Protoglobin PF11563.8 EEA24898.1 - 0.00015 21.7 0.1 0.00029 20.8 0.1 1.5 1 1 0 1 1 1 1 Protoglobin FAD_binding_8 PF08022.12 EEA24898.1 - 0.026 14.6 0.0 0.063 13.4 0.0 1.6 1 0 0 1 1 1 0 FAD-binding domain DSBA PF01323.20 EEA24899.1 - 1.8e-28 99.7 0.0 2.1e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EEA24899.1 - 0.05 13.8 0.0 0.18 12.0 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin MFS_1 PF07690.16 EEA24900.1 - 3.9e-24 85.2 32.0 4.7e-24 85.0 31.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA24900.1 - 2.3e-07 30.5 15.5 0.0013 18.1 3.2 2.6 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB UPF0239 PF06783.11 EEA24900.1 - 0.1 12.8 0.1 0.8 9.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Ig_mannosidase PF17753.1 EEA24900.1 - 0.12 12.1 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 Ig-fold domain FAD_binding_3 PF01494.19 EEA24901.1 - 1.5e-15 57.4 0.2 5.7e-15 55.4 0.2 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA24901.1 - 8.9e-05 21.9 0.6 0.13 11.5 0.1 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA24901.1 - 0.00021 21.5 0.0 0.00046 20.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA24901.1 - 0.00044 20.3 0.1 0.0011 19.0 0.1 1.7 1 1 0 1 1 1 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EEA24901.1 - 0.001 18.1 0.2 0.075 11.9 0.1 2.1 2 0 0 2 2 2 2 Tryptophan halogenase DAO PF01266.24 EEA24901.1 - 0.0066 16.1 3.1 0.018 14.6 0.2 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EEA24901.1 - 0.0067 15.8 0.1 0.015 14.6 0.1 1.6 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EEA24901.1 - 0.01 14.9 0.5 0.1 11.6 0.5 2.0 1 1 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 EEA24901.1 - 0.067 13.8 0.1 1.4 9.5 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase APH PF01636.23 EEA24902.1 - 1.8e-05 24.8 0.0 2e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family BTB PF00651.31 EEA24903.1 - 0.036 14.3 0.0 0.055 13.7 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain BUD22 PF09073.10 EEA24904.1 - 0.0046 16.4 20.1 0.0058 16.0 20.1 1.2 1 0 0 1 1 1 1 BUD22 SDA1 PF05285.12 EEA24904.1 - 0.024 14.1 17.0 0.031 13.7 17.0 1.3 1 0 0 1 1 1 0 SDA1 Mak16 PF04874.14 EEA24904.1 - 5.4 7.7 18.5 1.3 9.7 3.3 2.5 2 0 0 2 2 2 0 Mak16 protein C-terminal region Caskin-Pro-rich PF16907.5 EEA24904.1 - 7.9 7.1 7.8 1.7 9.2 3.1 2.5 2 1 0 2 2 2 0 Proline rich region of Caskin proteins Velvet PF11754.8 EEA24905.1 - 9.7e-95 317.2 0.0 1.2e-94 316.9 0.0 1.0 1 0 0 1 1 1 1 Velvet factor DUF3474 PF11960.8 EEA24907.1 - 0.082 13.1 1.3 0.15 12.2 1.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3474) NmrA PF05368.13 EEA24908.1 - 7.7e-31 107.4 0.0 1.7e-30 106.3 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA24908.1 - 5.7e-10 39.4 0.0 7.8e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA24908.1 - 8.3e-06 25.4 0.0 1.9e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EEA24908.1 - 0.0015 18.8 0.0 0.0029 17.9 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain GDP_Man_Dehyd PF16363.5 EEA24908.1 - 0.0044 16.5 0.0 0.036 13.5 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EEA24908.1 - 0.03 13.3 0.0 0.05 12.6 0.0 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Fungal_trans PF04082.18 EEA24909.1 - 1.7e-08 33.8 0.0 3.7e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24909.1 - 1e-06 28.7 12.5 2.4e-06 27.6 12.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GP63 PF17471.2 EEA24909.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Gene product 63 Aminotran_5 PF00266.19 EEA24910.1 - 3.1e-16 59.3 0.0 9.8e-16 57.7 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EEA24910.1 - 0.00035 19.9 0.0 0.0022 17.2 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EEA24910.1 - 0.019 14.3 0.1 0.12 11.7 0.1 2.0 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Fibrillarin PF01269.17 EEA24910.1 - 0.11 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin Ku_C PF03730.14 EEA24911.1 - 0.13 13.0 1.6 0.24 12.1 0.1 2.2 2 1 0 2 2 2 0 Ku70/Ku80 C-terminal arm Pam17 PF08566.10 EEA24913.1 - 5.4e-68 228.0 0.0 8.2e-68 227.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 CLLAC PF15675.5 EEA24913.1 - 0.21 11.2 1.1 0.45 10.1 1.1 1.5 1 0 0 1 1 1 0 CLLAC-motif containing domain Far-17a_AIG1 PF04750.14 EEA24914.1 - 2.6e-58 196.7 10.3 3e-58 196.5 10.3 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF5336 PF17270.2 EEA24914.1 - 0.14 11.8 0.8 0.51 10.0 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5336) Fungal_trans_2 PF11951.8 EEA24915.1 - 2.7e-52 177.9 0.8 3.8e-52 177.4 0.8 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24915.1 - 4.6e-10 39.4 9.1 9.8e-10 38.4 9.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3602 PF12223.8 EEA24916.1 - 4e-16 59.4 10.3 9.3e-12 45.4 1.8 2.9 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) eIF2A PF08662.11 EEA24917.1 - 1.3e-34 119.8 0.8 7.8e-32 110.7 0.4 3.5 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EEA24917.1 - 2.8e-08 33.5 0.0 6.4e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EEA24917.1 - 0.054 14.4 1.1 2.2 9.3 0.1 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat SWIB PF02201.18 EEA24918.1 - 4.2e-27 93.8 0.1 1.2e-26 92.3 0.1 1.9 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 EEA24918.1 - 1.2e-10 41.1 0.0 3.7e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 DEK C terminal domain zf-C3HC4_3 PF13920.6 EEA24918.1 - 7e-07 29.0 8.8 7e-07 29.0 8.8 3.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA24918.1 - 0.0052 16.6 10.5 0.0052 16.6 10.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Vps51 PF08700.11 EEA24918.1 - 0.11 12.5 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 Vps51/Vps67 MutS_V PF00488.21 EEA24919.1 - 4.3e-62 209.5 0.7 7.1e-62 208.8 0.7 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EEA24919.1 - 2.6e-35 122.4 2.9 6.5e-35 121.1 2.9 1.7 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 EEA24919.1 - 2.2e-09 37.7 0.0 4.9e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EEA24919.1 - 4.9e-09 36.4 0.1 1.1e-08 35.3 0.1 1.7 1 0 0 1 1 1 1 MutS family domain IV WD40 PF00400.32 EEA24920.1 - 5.8e-56 185.2 20.9 3.8e-10 40.2 0.0 9.0 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA24920.1 - 9.2e-25 86.8 1.4 0.00082 19.6 0.0 6.8 3 3 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA24920.1 - 1.7e-07 31.3 0.0 0.0036 17.2 0.0 3.7 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA24920.1 - 2.4e-06 26.7 0.2 0.17 10.8 0.0 4.1 3 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EEA24920.1 - 3.5e-06 26.0 3.3 4.4 5.8 0.0 5.4 2 2 4 6 6 6 3 Nucleoporin Nup120/160 NLE PF08154.12 EEA24920.1 - 0.00018 22.0 0.0 0.00032 21.2 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain WD40_like PF17005.5 EEA24920.1 - 0.00037 19.9 0.0 3.3 6.9 0.0 4.3 3 2 2 5 5 5 2 WD40-like domain PD40 PF07676.12 EEA24920.1 - 0.011 15.7 0.1 24 5.0 0.0 4.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EEA24920.1 - 0.018 14.4 0.4 9 5.5 0.0 3.7 3 2 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal DUF5046 PF16465.5 EEA24920.1 - 0.041 13.3 0.0 3.1 7.2 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5046) DUF4550 PF15084.6 EEA24920.1 - 0.067 13.6 0.2 0.32 11.4 0.1 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4550) CAP PF00188.26 EEA24921.1 - 2.5e-19 70.4 4.3 4.6e-19 69.5 4.3 1.4 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Epimerase PF01370.21 EEA24922.1 - 1.6e-19 70.4 0.0 3e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA24922.1 - 3.1e-16 59.2 0.0 6.2e-16 58.2 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EEA24922.1 - 4.4e-12 45.7 0.1 2.3e-11 43.3 0.1 1.8 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EEA24922.1 - 6.4e-11 42.2 0.0 1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EEA24922.1 - 1.6e-06 28.1 0.0 2.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EEA24922.1 - 3.5e-06 27.1 0.0 6.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EEA24922.1 - 0.00012 21.6 0.0 0.00025 20.6 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.13 EEA24922.1 - 0.00034 20.3 0.3 0.0016 18.0 0.1 2.1 3 0 0 3 3 3 1 NmrA-like family Polysacc_synt_2 PF02719.15 EEA24922.1 - 0.0016 17.6 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA24922.1 - 0.1 11.7 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Sec10 PF07393.11 EEA24923.1 - 2.9e-160 535.1 0.0 3.7e-160 534.7 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 EEA24923.1 - 4.4e-06 26.5 0.0 1.1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA24923.1 - 3.2e-05 23.7 0.0 6.9e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EEA24923.1 - 0.013 15.3 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 F-box BCS1_N PF08740.11 EEA24924.1 - 3.2e-35 121.8 0.1 5.2e-35 121.1 0.1 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EEA24924.1 - 5.4e-24 85.1 0.0 9.5e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA24924.1 - 1.1e-05 25.3 0.0 2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EEA24924.1 - 0.014 14.6 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 EEA24924.1 - 0.015 15.3 0.0 0.043 13.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EEA24924.1 - 0.029 14.7 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EEA24924.1 - 0.031 14.8 0.0 0.062 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA24924.1 - 0.039 14.3 0.0 0.13 12.7 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain TIP49 PF06068.13 EEA24924.1 - 0.22 10.7 0.0 0.38 9.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Cytochrom_C1 PF02167.15 EEA24925.1 - 9.2e-93 310.0 0.0 1.2e-92 309.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EEA24925.1 - 0.0076 16.5 0.1 0.017 15.4 0.1 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Phi-29_GP3 PF05435.11 EEA24925.1 - 0.081 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Phi-29 DNA terminal protein GP3 Cytochrom_C PF00034.21 EEA24925.1 - 0.15 13.2 1.8 0.6 11.3 0.3 2.7 3 1 0 3 3 3 0 Cytochrome c AIG2_2 PF13772.6 EEA24926.1 - 0.0033 17.8 0.1 0.01 16.2 0.0 1.8 2 0 0 2 2 2 1 AIG2-like family Cyto_heme_lyase PF01265.17 EEA24927.1 - 0.82 9.2 7.4 1.6 8.3 7.4 1.4 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase DAHP_synth_1 PF00793.20 EEA24929.1 - 3.5e-104 347.5 0.0 4.1e-104 347.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family RSN1_7TM PF02714.15 EEA24930.1 - 2.5e-81 273.0 25.1 4e-81 272.3 25.1 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EEA24930.1 - 8.9e-42 143.3 0.1 1.4e-41 142.7 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EEA24930.1 - 1.5e-36 125.5 0.1 1.5e-36 125.5 0.1 2.5 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport Lig_chan PF00060.26 EEA24930.1 - 0.074 12.9 0.2 5.8 6.8 0.0 3.1 3 1 0 3 3 3 0 Ligand-gated ion channel REC1 PF18501.1 EEA24930.1 - 0.14 12.0 0.2 0.28 11.0 0.2 1.4 1 0 0 1 1 1 0 Alpha helical recognition lobe domain Curto_V3 PF07436.11 EEA24930.1 - 1.1 9.7 3.2 4.3 7.8 3.2 2.0 1 0 0 1 1 1 0 Curtovirus V3 protein Anoctamin PF04547.12 EEA24930.1 - 1.2 7.9 11.5 0.012 14.5 1.2 2.3 1 1 1 2 2 2 0 Calcium-activated chloride channel F-box-like PF12937.7 EEA24931.1 - 0.00014 21.7 0.1 0.00036 20.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like PDR_CDR PF06422.12 EEA24932.1 - 0.024 14.5 0.1 0.039 13.8 0.1 1.4 1 0 0 1 1 1 0 CDR ABC transporter PAC1 PF16094.5 EEA24932.1 - 0.032 13.4 0.0 0.034 13.3 0.0 1.1 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 NrsF PF06532.11 EEA24932.1 - 0.11 12.3 2.1 1.9 8.1 0.4 2.1 1 1 1 2 2 2 0 Negative regulator of sigma F Git3 PF11710.8 EEA24933.1 - 1.9e-28 99.6 13.9 7.1e-28 97.8 13.9 1.8 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EEA24933.1 - 1.8e-15 56.8 0.2 5.2e-15 55.3 0.2 1.8 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EEA24933.1 - 0.00045 19.4 14.7 0.00068 18.9 14.7 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 EEA24933.1 - 0.00063 19.1 11.6 0.00066 19.1 10.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) OppC_N PF12911.7 EEA24933.1 - 0.21 11.6 1.8 14 5.8 0.2 2.9 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF4969 PF16339.5 EEA24933.1 - 0.61 10.5 7.8 1.5 9.2 0.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4969) G_glu_transpept PF01019.21 EEA24935.1 - 2.5e-167 557.7 0.0 2.9e-167 557.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase MFS_1 PF07690.16 EEA24936.1 - 6.6e-15 54.9 34.0 3.5e-13 49.2 32.4 2.7 1 1 0 1 1 1 1 Major Facilitator Superfamily SLX9 PF15341.6 EEA24937.1 - 2.6e-37 128.1 12.4 3.2e-37 127.9 12.4 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 NAD_Gly3P_dh_N PF01210.23 EEA24938.1 - 3.4e-47 160.3 0.0 6.5e-47 159.4 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EEA24938.1 - 3.1e-44 150.7 0.1 5.6e-44 149.9 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 EEA24938.1 - 0.093 13.3 0.0 16 6.2 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent hDGE_amylase PF14701.6 EEA24939.1 - 5e-185 615.8 0.0 6.5e-185 615.4 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EEA24939.1 - 9.8e-123 409.9 0.0 2.6e-122 408.5 0.0 1.7 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EEA24939.1 - 7.2e-86 288.0 0.0 1.1e-85 287.3 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EEA24939.1 - 1.1e-31 108.8 0.0 2.3e-31 107.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 EEA24939.1 - 0.0037 16.9 0.0 0.0081 15.8 0.0 1.5 1 0 0 1 1 1 1 Alpha amylase, catalytic domain NAD_binding_11 PF14833.6 EEA24940.1 - 3e-40 137.2 0.9 2.1e-29 102.2 0.0 2.2 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 EEA24940.1 - 3e-36 125.0 0.2 1.4e-35 122.8 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EEA24940.1 - 0.00037 20.4 0.1 0.00082 19.3 0.1 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EEA24940.1 - 0.00041 20.9 0.1 0.0035 17.9 0.0 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh PF00984.19 EEA24940.1 - 0.0042 17.2 0.5 0.34 11.1 0.0 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain F_bP_aldolase PF01116.20 EEA24941.1 - 3.1e-85 286.1 0.2 3.4e-85 285.9 0.2 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II F_bP_aldolase PF01116.20 EEA24942.1 - 3.1e-85 286.1 0.2 3.4e-85 285.9 0.2 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Methyltransf_2 PF00891.18 EEA24943.1 - 2.4e-27 95.6 0.0 3.7e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain DUF2805 PF10985.8 EEA24943.1 - 0.043 14.2 0.0 0.093 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2805) Sigma70_r4 PF04545.16 EEA24943.1 - 0.094 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 Methyltransf_4 PF02390.17 EEA24943.1 - 0.17 11.4 0.1 0.77 9.2 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase MFS_1 PF07690.16 EEA24945.1 - 9.6e-14 51.1 13.7 1.2e-13 50.8 13.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyoxalase PF00903.25 EEA24946.1 - 3.3e-24 85.5 0.6 1.7e-16 60.6 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EEA24946.1 - 1.1e-15 57.8 0.2 5.2e-08 33.1 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EEA24946.1 - 1.3e-07 31.9 0.0 0.0074 16.4 0.0 3.0 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EEA24946.1 - 0.00022 21.4 0.1 0.0048 17.1 0.0 2.7 3 0 0 3 3 3 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_6 PF18029.1 EEA24946.1 - 0.018 15.8 0.0 2 9.3 0.0 2.5 2 1 0 2 2 2 0 Glyoxalase-like domain TPR_17 PF13431.6 EEA24947.1 - 0.046 14.1 0.1 0.12 12.8 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat FMN_dh PF01070.18 EEA24948.1 - 2e-115 385.5 0.1 2.4e-115 385.3 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EEA24948.1 - 5.9e-16 58.4 0.0 5.8e-15 55.2 0.0 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 EEA24948.1 - 0.00015 20.9 0.1 0.00083 18.5 0.0 2.2 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EEA24948.1 - 0.00041 19.6 0.0 0.00075 18.7 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EEA24948.1 - 0.0017 17.8 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EEA24948.1 - 0.038 13.4 0.0 0.23 10.9 0.0 1.9 2 0 0 2 2 2 0 Histidine biosynthesis protein DHO_dh PF01180.21 EEA24948.1 - 0.089 12.0 0.1 0.54 9.4 0.0 2.0 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Aldedh PF00171.22 EEA24949.1 - 1.3e-90 304.2 0.0 1.4e-90 304.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DRTGG PF07085.12 EEA24949.1 - 0.052 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 DRTGG domain DDE_1 PF03184.19 EEA24950.1 - 3.2e-23 82.3 0.0 6e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA24950.1 - 7.5e-09 35.5 0.3 2.6e-08 33.8 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA24950.1 - 0.03 14.5 0.0 0.44 10.7 0.0 2.3 2 0 0 2 2 2 0 Transcription factor Pcc1 Fer2_3 PF13085.6 EEA24951.1 - 1.7e-31 108.5 0.0 2.9e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EEA24951.1 - 1.5e-08 35.0 6.5 1.5e-08 35.0 6.5 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EEA24951.1 - 6.1e-07 29.5 3.8 6.1e-07 29.5 3.8 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EEA24951.1 - 2.1e-06 28.1 8.5 2.1e-06 28.1 8.5 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 EEA24951.1 - 0.0032 18.0 4.7 0.0032 18.0 4.7 2.4 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EEA24951.1 - 0.013 15.4 0.4 0.013 15.4 0.4 2.3 3 0 0 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain Fer4_18 PF13746.6 EEA24951.1 - 0.67 10.2 6.3 0.68 10.1 0.1 2.6 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 EEA24951.1 - 2.7 8.2 12.2 39 4.5 5.4 2.9 2 1 2 4 4 4 0 4Fe-4S dicluster domain adh_short PF00106.25 EEA24952.1 - 1.3e-34 119.3 0.0 1.7e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA24952.1 - 7.5e-29 100.9 0.0 9.5e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA24952.1 - 4.5e-06 26.7 0.0 0.0002 21.3 0.0 2.2 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA24952.1 - 0.014 14.8 0.0 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DFP PF04127.15 EEA24952.1 - 0.093 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein FAD_binding_4 PF01565.23 EEA24953.1 - 1.1e-25 90.0 0.0 1.7e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EEA24953.1 - 7.4e-07 29.0 0.0 1.6e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain Pyr_redox_2 PF07992.14 EEA24954.1 - 5.2e-19 68.6 0.0 3.8e-11 42.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA24954.1 - 0.0028 16.8 0.1 0.019 14.1 0.0 2.0 1 1 1 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EEA24954.1 - 0.0097 14.6 0.0 0.12 11.1 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EEA24954.1 - 0.019 15.2 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA24954.1 - 0.034 13.2 0.0 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Amino_oxidase PF01593.24 EEA24954.1 - 0.05 12.9 0.0 0.2 10.9 0.0 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EEA24954.1 - 0.057 13.4 0.3 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding ThiS PF02597.20 EEA24954.1 - 0.067 13.8 0.2 7.6 7.3 0.0 3.4 3 1 1 4 4 4 0 ThiS family Thi4 PF01946.17 EEA24954.1 - 0.082 12.1 0.1 0.17 11.1 0.1 1.4 1 0 0 1 1 1 0 Thi4 family K_oxygenase PF13434.6 EEA24954.1 - 0.14 11.3 0.4 3 6.9 0.0 2.3 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EEA24954.1 - 0.18 10.8 0.2 12 4.9 0.1 2.1 1 1 0 2 2 2 0 Lycopene cyclase protein NAD_binding_10 PF13460.6 EEA24955.1 - 4.8e-14 52.7 0.0 2.6e-13 50.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EEA24955.1 - 3.1e-13 49.8 0.0 4.8e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EEA24955.1 - 0.013 15.4 0.0 0.17 11.8 0.0 2.3 2 0 0 2 2 2 0 KR domain Epimerase PF01370.21 EEA24955.1 - 0.023 14.2 0.1 0.2 11.1 0.0 2.4 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF659 PF04937.15 EEA24956.1 - 1.7e-10 40.9 1.0 3.1e-10 40.1 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Dimer_Tnp_hAT PF05699.14 EEA24956.1 - 2.8e-06 27.0 0.1 8.9e-06 25.4 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2110 PF09883.9 EEA24956.1 - 0.055 13.1 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) APG6_N PF17675.1 EEA24956.1 - 0.25 11.9 6.9 0.75 10.3 6.9 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region DPBB_1 PF03330.18 EEA24957.1 - 2.8e-05 24.3 0.0 4.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Lytic transglycolase FAM70 PF14967.6 EEA24957.1 - 0.035 13.6 0.4 0.055 12.9 0.0 1.5 2 0 0 2 2 2 0 FAM70 protein DUF2273 PF10031.9 EEA24957.1 - 0.58 10.2 4.4 1 9.4 4.4 1.3 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) ThiF PF00899.21 EEA24959.1 - 9.1e-60 202.0 0.0 1.2e-59 201.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EEA24959.1 - 6.5e-11 42.7 0.0 1.4e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain S1-P1_nuclease PF02265.16 EEA24960.1 - 7.2e-71 239.0 0.2 8.3e-71 238.8 0.2 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease Fungal_trans PF04082.18 EEA24961.1 - 5e-06 25.7 0.8 8.2e-06 25.0 0.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 EEA24962.1 - 8.9e-19 68.0 0.0 1.1e-18 67.6 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA24962.1 - 2.3e-12 47.2 0.0 4.7e-12 46.2 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA24962.1 - 0.00073 18.6 0.1 0.0011 18.1 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DXP_reductoisom PF02670.16 EEA24962.1 - 0.0022 18.7 0.3 0.0044 17.7 0.3 1.6 1 1 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Semialdhyde_dh PF01118.24 EEA24962.1 - 0.005 17.3 0.1 0.0082 16.6 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EEA24962.1 - 0.0071 15.5 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EEA24962.1 - 0.033 13.6 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EEA24962.1 - 0.037 14.1 0.1 0.057 13.5 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus HlyE PF06109.13 EEA24963.1 - 0.043 13.1 0.2 0.097 12.0 0.1 1.6 2 0 0 2 2 2 0 Haemolysin E (HlyE) DUF948 PF06103.11 EEA24963.1 - 0.05 13.9 1.5 0.55 10.5 0.1 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 EEA24963.1 - 0.41 10.7 12.8 0.12 12.4 4.3 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Abhydrolase_4 PF08386.10 EEA24964.1 - 4.4e-21 74.9 0.0 5.4e-19 68.2 0.0 2.6 2 0 0 2 2 2 2 TAP-like protein Abhydrolase_1 PF00561.20 EEA24964.1 - 1.4e-13 51.1 0.0 1.2e-10 41.5 0.0 2.6 2 1 0 3 3 3 2 alpha/beta hydrolase fold Aminotran_3 PF00202.21 EEA24965.1 - 3.6e-92 309.1 0.0 4.3e-92 308.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans PF04082.18 EEA24966.1 - 1.6e-10 40.5 0.0 2.8e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA24966.1 - 0.00026 21.1 8.3 0.0005 20.1 8.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DDE_1 PF03184.19 EEA24967.1 - 6.5e-17 61.7 0.0 1.5e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC_4 PF14392.6 EEA24967.1 - 0.15 11.8 0.9 0.38 10.5 0.9 1.7 1 0 0 1 1 1 0 Zinc knuckle Asp PF00026.23 EEA24968.1 - 8e-47 160.2 0.0 9.6e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA24968.1 - 0.0064 17.1 0.0 2 9.1 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease CE2_N PF17996.1 EEA24969.1 - 9.5e-19 67.4 0.0 2e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Lipase_GDSL_2 PF13472.6 EEA24969.1 - 1.7e-16 61.1 1.5 2.6e-16 60.5 1.5 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CBM_1 PF00734.18 EEA24969.1 - 1.6e-13 50.3 9.7 3.3e-13 49.3 9.7 1.6 1 0 0 1 1 1 1 Fungal cellulose binding domain Lipase_GDSL PF00657.22 EEA24969.1 - 4.1e-07 30.2 0.1 7.4e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SKG6 PF08693.10 EEA24970.1 - 0.0002 20.7 3.1 0.00041 19.7 3.1 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Podoplanin PF05808.11 EEA24970.1 - 0.0014 18.7 5.0 0.0022 18.1 5.0 1.2 1 0 0 1 1 1 1 Podoplanin DUF2207 PF09972.9 EEA24970.1 - 0.0024 16.7 0.0 0.0031 16.3 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Stevor PF17410.2 EEA24970.1 - 0.0037 16.9 3.7 0.0055 16.3 3.7 1.1 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame Glycophorin_A PF01102.18 EEA24970.1 - 0.028 14.6 0.6 0.048 13.9 0.6 1.3 1 0 0 1 1 1 0 Glycophorin A TMEM154 PF15102.6 EEA24970.1 - 0.075 12.9 0.9 0.13 12.2 0.9 1.3 1 0 0 1 1 1 0 TMEM154 protein family Gram_pos_anchor PF00746.21 EEA24970.1 - 0.082 12.9 1.2 0.25 11.3 1.2 1.9 1 0 0 1 1 1 0 LPXTG cell wall anchor motif RCR PF12273.8 EEA24970.1 - 0.12 13.0 11.0 5.8 7.6 11.0 2.3 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red TrbL PF04610.14 EEA24970.1 - 0.46 10.2 10.0 0.62 9.8 10.0 1.1 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein DUF2076 PF09849.9 EEA24970.1 - 3.9 7.4 11.9 6.6 6.7 11.9 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Glyco_hydro_31 PF01055.26 EEA24971.1 - 1e-112 377.6 2.1 1.5e-112 377.1 2.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EEA24971.1 - 0.00082 19.7 0.1 0.0083 16.4 0.1 2.6 2 1 0 2 2 2 1 Galactose mutarotase-like DUF4968 PF16338.5 EEA24971.1 - 0.033 14.5 0.0 0.053 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4968) MFS_1 PF07690.16 EEA24972.1 - 1.5e-47 162.2 36.7 1.5e-47 162.2 36.7 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA24972.1 - 5.6e-14 51.9 7.5 5.6e-14 51.9 7.5 2.6 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 EEA24972.1 - 2.3e-07 30.5 4.0 2.3e-07 30.5 4.0 2.4 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EEA24972.1 - 2.7 6.2 20.6 0.1 10.9 7.1 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Aminotran_5 PF00266.19 EEA24973.1 - 1.3e-26 93.4 0.0 2.2e-17 63.1 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class-V p450 PF00067.22 EEA24974.1 - 6.8e-82 275.6 0.0 9.1e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 EEA24975.1 - 1.7e-20 73.6 0.0 4e-20 72.3 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA24975.1 - 8.1e-10 38.4 0.1 5.3e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA24975.1 - 5.4e-09 35.6 0.4 6.5e-08 32.1 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EEA24975.1 - 1e-07 31.9 0.0 0.00021 21.0 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA24975.1 - 4.6e-06 26.8 0.1 1e-05 25.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA24975.1 - 3.1e-05 24.4 0.3 0.0031 18.0 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA24975.1 - 4e-05 22.5 0.1 0.00015 20.6 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EEA24975.1 - 8.1e-05 22.1 0.1 0.0002 20.9 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA24975.1 - 0.0017 17.7 0.1 0.0028 17.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA24975.1 - 0.002 17.3 0.0 0.0029 16.8 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EEA24975.1 - 0.0054 16.1 0.1 0.0087 15.4 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EEA24975.1 - 0.021 14.1 0.0 0.35 10.1 0.0 2.4 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 EEA24975.1 - 0.024 13.9 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EEA24975.1 - 0.039 12.8 0.1 0.25 10.1 0.1 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EEA24975.1 - 0.14 11.2 0.1 0.35 9.9 0.1 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein UDPG_MGDP_dh_N PF03721.14 EEA24975.1 - 0.19 11.3 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MFS_1 PF07690.16 EEA24976.1 - 3.5e-35 121.6 24.6 3.5e-35 121.6 24.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Telomerase_RBD PF12009.8 EEA24977.1 - 2.8e-46 156.9 0.5 1e-45 155.2 0.2 2.2 1 1 1 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EEA24977.1 - 9.7e-15 54.7 0.3 8.3e-11 41.8 0.0 2.8 3 0 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) PBP PF01161.20 EEA24978.1 - 4.8e-15 56.1 0.0 5.6e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein RhoGEF PF00621.20 EEA24979.1 - 8.1e-37 127.2 0.1 1.7e-36 126.2 0.1 1.6 1 0 0 1 1 1 1 RhoGEF domain TFIIA PF03153.13 EEA24979.1 - 0.00013 22.1 20.7 0.00013 22.1 20.7 3.0 4 0 0 4 4 4 1 Transcription factor IIA, alpha/beta subunit DUF2457 PF10446.9 EEA24979.1 - 0.00046 19.5 32.3 0.00046 19.5 32.3 4.6 5 1 0 6 6 6 1 Protein of unknown function (DUF2457) BSP_II PF05432.11 EEA24979.1 - 0.039 13.6 21.3 0.12 12.0 21.3 1.9 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Afi1 PF07792.12 EEA24979.1 - 0.044 14.3 9.3 0.022 15.2 6.2 2.2 1 1 1 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RXT2_N PF08595.11 EEA24979.1 - 0.12 12.4 13.9 0.5 10.4 13.9 2.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 EEA24979.1 - 0.22 9.6 35.8 0.35 8.9 35.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC27 PF09507.10 EEA24979.1 - 0.25 10.7 22.9 0.063 12.7 12.8 2.6 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 EEA24979.1 - 0.58 8.3 28.8 1 7.5 28.8 1.3 1 0 0 1 1 1 0 Nop14-like family Cytomega_UL84 PF06284.11 EEA24979.1 - 5.3 5.4 16.1 9.1 4.6 16.1 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Peptidase_C48 PF02902.19 EEA24980.1 - 3.5e-18 66.3 0.4 1.9e-17 63.9 0.4 2.0 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF4951 PF16309.5 EEA24980.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) GST_N_3 PF13417.6 EEA24981.1 - 1.2e-12 48.1 0.0 2.7e-12 46.9 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA24981.1 - 3.1e-10 40.2 0.0 8.3e-10 38.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA24981.1 - 1.5e-09 38.0 0.1 2.7e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA24981.1 - 2.5e-09 37.3 0.0 5.4e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA24981.1 - 1.6e-08 34.6 0.1 2.5e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA24981.1 - 9e-05 22.4 0.5 0.00015 21.7 0.2 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EEA24981.1 - 0.0018 18.8 0.0 0.025 15.1 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EEA24981.1 - 0.013 16.3 0.0 0.032 15.0 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain Pro-kuma_activ PF09286.11 EEA24982.1 - 6.1e-37 127.1 0.0 4.2e-36 124.4 0.0 2.1 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain DUF5609 PF18429.1 EEA24982.1 - 0.0057 16.4 0.0 0.13 12.1 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5609) Peptidase_S8 PF00082.22 EEA24982.1 - 0.016 14.5 0.0 0.05 12.9 0.0 1.6 1 1 0 1 1 1 0 Subtilase family Not3 PF04065.15 EEA24983.1 - 1.8e-85 286.0 18.9 2.7e-85 285.5 18.9 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EEA24983.1 - 2.4e-44 150.6 10.7 6.4e-44 149.2 10.7 1.8 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.9 EEA24983.1 - 0.066 13.1 2.2 0.17 11.8 2.2 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) RPW8 PF05659.11 EEA24983.1 - 0.085 12.6 8.6 0.022 14.4 2.1 2.3 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Snf7 PF03357.21 EEA24983.1 - 0.086 12.4 9.5 0.67 9.5 4.9 2.3 1 1 1 2 2 2 0 Snf7 MCM3AP_GANP PF16769.5 EEA24983.1 - 0.11 10.7 7.7 0.17 10.1 7.7 1.2 1 0 0 1 1 1 0 MCM3AP domain of GANP LPP PF04728.13 EEA24983.1 - 0.13 12.7 0.6 0.6 10.5 0.3 2.3 2 0 0 2 2 1 0 Lipoprotein leucine-zipper Snapin_Pallidin PF14712.6 EEA24983.1 - 0.19 12.2 5.7 0.55 10.7 0.8 2.5 2 0 0 2 2 2 0 Snapin/Pallidin DUF1192 PF06698.11 EEA24983.1 - 0.27 11.3 3.4 0.2 11.7 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Cep57_MT_bd PF06657.13 EEA24983.1 - 0.38 11.2 5.2 9.5 6.8 0.4 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 PI3K_P85_iSH2 PF16454.5 EEA24983.1 - 0.4 10.3 14.2 0.4 10.3 1.3 2.9 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Mu-like_Pro PF10123.9 EEA24983.1 - 1.4 8.4 7.3 3.1 7.2 7.3 1.5 1 0 0 1 1 1 0 Mu-like prophage I protein Tyr_Deacylase PF02580.16 EEA24984.1 - 1.3e-53 181.4 0.1 1.5e-53 181.2 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DMRL_synthase PF00885.19 EEA24984.1 - 0.067 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 6,7-dimethyl-8-ribityllumazine synthase TPP_enzyme_N PF02776.18 EEA24984.1 - 0.13 11.9 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Tyr_Deacylase PF02580.16 EEA24985.1 - 1.3e-53 181.4 0.1 1.5e-53 181.2 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DMRL_synthase PF00885.19 EEA24985.1 - 0.067 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 6,7-dimethyl-8-ribityllumazine synthase TPP_enzyme_N PF02776.18 EEA24985.1 - 0.13 11.9 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Tyr_Deacylase PF02580.16 EEA24986.1 - 3.1e-52 176.9 0.0 3.5e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Tyr_Deacylase PF02580.16 EEA24987.1 - 1.3e-53 181.4 0.1 1.5e-53 181.2 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DMRL_synthase PF00885.19 EEA24987.1 - 0.067 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 6,7-dimethyl-8-ribityllumazine synthase TPP_enzyme_N PF02776.18 EEA24987.1 - 0.13 11.9 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain DDE_1 PF03184.19 EEA24988.1 - 1.6e-40 138.6 2.2 3.3e-40 137.6 0.3 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_ABP1_N PF18107.1 EEA24988.1 - 1.1e-20 73.0 1.7 1.1e-20 73.0 1.7 2.0 2 0 0 2 2 2 1 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 EEA24988.1 - 3.6e-17 62.1 2.1 3.6e-17 62.1 2.1 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_32 PF13565.6 EEA24988.1 - 0.11 13.2 0.9 1.2 9.8 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain Pro_isomerase PF00160.21 EEA24989.1 - 4.6e-50 170.0 0.3 7.1e-50 169.4 0.3 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EEA24989.1 - 6.7e-06 25.8 3.1 0.00051 19.9 0.9 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA24989.1 - 3.5e-05 23.4 3.1 0.0001 22.0 0.7 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA24989.1 - 0.002 18.2 1.2 0.002 18.2 1.2 3.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EEA24989.1 - 0.014 15.5 1.3 0.031 14.4 1.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA24989.1 - 0.081 13.6 8.9 0.23 12.1 8.5 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA24989.1 - 0.17 12.8 6.7 0.2 12.5 2.8 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA24989.1 - 0.27 11.6 3.9 5.6 7.3 3.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA24989.1 - 1.1 10.0 3.7 6.2 7.7 0.4 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat EI24 PF07264.11 EEA24990.1 - 1.7e-13 51.2 3.3 9.7e-06 25.9 1.2 2.2 1 1 1 2 2 2 2 Etoposide-induced protein 2.4 (EI24) Wzy_C_2 PF11846.8 EEA24990.1 - 0.036 14.0 0.7 0.063 13.2 0.0 1.7 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal DUF4112 PF13430.6 EEA24990.1 - 0.044 14.0 0.1 1.4 9.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4112) DUF3742 PF12553.8 EEA24990.1 - 0.17 12.0 0.0 0.46 10.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) EI24 PF07264.11 EEA24991.1 - 2.8e-05 24.4 2.7 4.6e-05 23.7 2.7 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Inp1 PF12634.7 EEA24992.1 - 1.4e-34 119.1 0.0 2.9e-34 118.0 0.0 1.6 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 SRP14 PF02290.15 EEA24993.1 - 3.6e-27 94.5 1.2 1.1e-26 93.0 1.2 1.8 1 1 0 1 1 1 1 Signal recognition particle 14kD protein Ank_2 PF12796.7 EEA24994.1 - 2.4e-10 40.9 0.5 4.5e-05 24.0 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA24994.1 - 5.5e-08 33.2 0.2 4e-07 30.4 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EEA24994.1 - 7.2e-06 26.2 0.1 0.021 15.2 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EEA24994.1 - 0.00015 22.0 0.1 0.016 15.5 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA24994.1 - 0.00027 21.1 0.6 0.25 12.0 0.0 3.4 2 2 0 2 2 2 1 Ankyrin repeat DUF2795 PF11387.8 EEA24994.1 - 0.2 11.9 0.5 0.55 10.5 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2795) MIF4G PF02854.19 EEA24995.1 - 6.9e-24 84.7 0.6 6.9e-24 84.7 0.6 2.3 3 0 0 3 3 3 1 MIF4G domain MA3 PF02847.17 EEA24995.1 - 7.6e-18 64.5 0.1 3.3e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 MA3 domain Aldedh PF00171.22 EEA24998.1 - 6.6e-169 562.3 0.2 7.5e-169 562.1 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Acetyltransf_1 PF00583.25 EEA24999.1 - 1.5e-13 51.0 0.0 2.3e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA24999.1 - 6.8e-08 32.8 0.1 1.1e-07 32.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA24999.1 - 1.6e-07 31.3 0.0 2.9e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA24999.1 - 0.0075 16.4 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EEA24999.1 - 0.017 15.3 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA24999.1 - 0.025 14.5 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein PIG-U PF06728.13 EEA25000.1 - 6.4e-124 413.9 25.8 7.5e-124 413.6 25.8 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Pescadillo_N PF06732.11 EEA25001.1 - 5.2e-125 416.5 0.2 5.2e-125 416.5 0.2 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EEA25001.1 - 4.1e-05 23.9 0.0 0.00021 21.6 0.0 2.2 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EEA25001.1 - 0.0011 19.2 0.0 0.071 13.5 0.0 3.2 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EEA25001.1 - 0.062 13.6 0.1 0.3 11.4 0.1 2.2 1 1 0 1 1 1 0 DNA ligase 3 BRCT domain adh_short PF00106.25 EEA25002.1 - 0.0015 18.0 0.0 0.0031 17.0 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase PRMT5 PF05185.16 EEA25002.1 - 0.087 12.7 0.3 0.25 11.2 0.1 1.7 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase Fungal_trans_2 PF11951.8 EEA25003.1 - 1.9e-07 30.3 3.4 2.9e-07 29.6 3.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25003.1 - 3.1e-07 30.4 14.1 5.6e-07 29.6 14.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydrolase_like PF13242.6 EEA25004.1 - 0.00015 21.8 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EEA25004.1 - 0.0048 17.2 0.0 0.081 13.2 0.0 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 EEA25004.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase LMWPc PF01451.21 EEA25005.1 - 4e-32 111.5 0.0 5.1e-27 95.0 0.0 2.1 2 0 0 2 2 2 2 Low molecular weight phosphotyrosine protein phosphatase NTase_sub_bind PF08780.11 EEA25005.1 - 0.12 12.4 0.1 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 Nucleotidyltransferase substrate binding protein like Ribosomal_L27A PF00828.19 EEA25006.1 - 5.1e-23 82.1 0.0 7.6e-23 81.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RAP PF08373.10 EEA25006.1 - 0.12 12.5 0.4 0.21 11.7 0.4 1.5 1 0 0 1 1 1 0 RAP domain MFS_1 PF07690.16 EEA25007.1 - 2.6e-30 105.6 30.2 4.5e-30 104.8 27.5 1.9 2 0 0 2 2 2 2 Major Facilitator Superfamily DLH PF01738.18 EEA25008.1 - 3.1e-09 36.7 0.0 4.1e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Chitin_synth_1 PF01644.17 EEA25009.1 - 1e-75 253.2 0.0 1.5e-75 252.6 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EEA25009.1 - 3.2e-30 103.9 0.0 7.2e-30 102.8 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EEA25009.1 - 1.2e-18 67.0 0.0 1.2e-18 67.0 0.0 2.1 1 1 0 2 2 2 1 Chitin synthase Chitin_synth_1 PF01644.17 EEA25010.1 - 1e-75 253.2 0.0 1.5e-75 252.6 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EEA25010.1 - 3.2e-30 103.9 0.0 7.2e-30 102.8 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EEA25010.1 - 1.2e-18 67.0 0.0 1.2e-18 67.0 0.0 2.1 1 1 0 2 2 2 1 Chitin synthase TMEM234 PF10639.9 EEA25011.1 - 1.2e-34 118.8 0.1 1e-26 93.2 0.1 2.0 2 0 0 2 2 2 2 Putative transmembrane family 234 EamA PF00892.20 EEA25011.1 - 0.00035 20.8 3.7 0.17 12.0 3.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family UBN_AB PF14075.6 EEA25011.1 - 0.075 12.8 0.1 0.098 12.4 0.1 1.1 1 0 0 1 1 1 0 Ubinuclein conserved middle domain PetM PF08041.11 EEA25011.1 - 0.082 12.5 1.3 0.082 12.5 1.3 2.1 3 0 0 3 3 3 0 PetM family of cytochrome b6f complex subunit 7 DDE_1 PF03184.19 EEA25012.1 - 7.4e-21 74.6 0.0 1.4e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA25012.1 - 5.9e-10 39.0 0.3 3.1e-09 36.7 0.3 2.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Hid1 PF12722.7 EEA25012.1 - 0.47 8.5 5.7 0.68 8.0 5.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MAJIN PF15077.6 EEA25012.1 - 1 9.1 7.9 2.1 8.1 7.9 1.5 1 0 0 1 1 1 0 Membrane-anchored junction protein XRN_M PF17846.1 EEA25012.1 - 2.4 7.0 7.2 7.8 5.3 6.6 1.9 2 0 0 2 2 2 0 Xrn1 helical domain DUF4407 PF14362.6 EEA25012.1 - 8.9 5.6 12.2 14 4.9 12.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) adh_short PF00106.25 EEA25013.1 - 3.9e-28 98.2 0.0 1.1e-27 96.8 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25013.1 - 1.4e-14 54.2 0.0 2.2e-14 53.6 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA25013.1 - 9e-10 38.7 0.1 1.2e-09 38.3 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA25013.1 - 0.00026 20.5 0.0 0.00032 20.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EEA25013.1 - 0.093 13.0 0.1 0.25 11.6 0.1 1.7 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain RibD_C PF01872.17 EEA25014.1 - 7.5e-29 101.0 0.0 3.6e-15 56.3 0.0 2.1 1 1 0 2 2 2 2 RibD C-terminal domain SUKH_6 PF14568.6 EEA25014.1 - 0.17 12.3 0.0 0.3 11.5 0.0 1.3 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall MRC1 PF09444.10 EEA25015.1 - 4.1e-40 137.7 23.7 4.1e-40 137.7 23.7 6.6 7 1 1 8 8 8 1 MRC1-like domain Plus-3 PF03126.18 EEA25016.1 - 5.3e-32 110.6 0.0 7.4e-31 106.9 0.0 2.5 2 0 0 2 2 2 1 Plus-3 domain COQ7 PF03232.13 EEA25017.1 - 9.6e-68 227.3 2.1 1.2e-67 227.0 2.1 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EEA25017.1 - 0.00018 21.9 0.4 0.0006 20.2 0.4 1.9 1 1 0 1 1 1 1 Rubrerythrin Asp PF00026.23 EEA25018.1 - 0.0046 16.4 0.0 0.0046 16.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease HsbA PF12296.8 EEA25019.1 - 3.2e-23 82.4 0.2 2.2e-22 79.7 0.3 1.9 2 0 0 2 2 2 1 Hydrophobic surface binding protein A DUF327 PF03885.13 EEA25019.1 - 0.0097 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF327) Topo-VIb_trans PF09239.11 EEA25019.1 - 0.14 12.0 0.0 2.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Topoisomerase VI B subunit, transducer Vps52 PF04129.12 EEA25019.1 - 0.5 9.0 2.6 5.2 5.7 0.1 2.1 1 1 1 2 2 2 0 Vps52 / Sac2 family Mss4 PF04421.13 EEA25020.1 - 0.09 12.9 0.1 0.32 11.2 0.1 1.9 2 0 0 2 2 2 0 Mss4 protein AAA_16 PF13191.6 EEA25022.1 - 0.00075 19.9 0.7 0.0079 16.6 0.7 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA25022.1 - 0.0017 18.6 0.0 0.0024 18.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EEA25022.1 - 0.015 14.5 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 EEA25022.1 - 0.07 13.1 0.0 1 9.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EEA25022.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EEA25022.1 - 0.15 11.4 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 EEA25022.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Cys_Met_Meta_PP PF01053.20 EEA25023.1 - 3.6e-69 233.1 0.0 9.3e-66 221.9 0.0 2.2 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme TPR_10 PF13374.6 EEA25023.1 - 5.2e-65 213.7 0.0 7.7e-13 47.9 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 EEA25023.1 - 3.4e-49 165.0 0.2 4.2e-16 59.0 0.1 5.7 1 1 3 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 EEA25023.1 - 5e-20 70.0 0.0 0.0046 16.9 0.0 5.8 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 EEA25023.1 - 4.2e-13 48.3 0.5 0.44 10.8 0.0 6.0 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EEA25023.1 - 2.4e-12 46.1 0.5 0.4 10.6 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA25023.1 - 4e-09 36.3 4.1 1.6e-07 31.0 5.0 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_17 PF13431.6 EEA25023.1 - 1.4e-07 31.3 3.3 1.2 9.7 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 EEA25023.1 - 6.7e-05 23.2 0.0 17 6.4 0.0 4.7 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA25023.1 - 0.00039 20.4 3.9 51 4.4 0.0 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA25023.1 - 0.00046 20.8 1.1 30 5.4 0.0 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Aminotran_5 PF00266.19 EEA25023.1 - 0.0013 17.8 0.0 0.0022 17.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V TPR_19 PF14559.6 EEA25023.1 - 0.0016 18.9 0.1 7.5 7.2 0.0 4.2 2 1 2 4 4 4 1 Tetratricopeptide repeat HemY_N PF07219.13 EEA25023.1 - 0.011 15.9 0.2 0.78 10.0 0.0 3.6 3 1 1 4 4 4 0 HemY protein N-terminus TPR_6 PF13174.6 EEA25023.1 - 0.03 14.9 2.8 3.5e+02 2.2 0.1 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 EEA25023.1 - 0.062 13.0 0.7 1.4 8.6 0.0 3.3 3 1 1 4 4 4 0 26S proteasome subunit RPN7 DUF4919 PF16266.5 EEA25023.1 - 0.079 12.9 0.7 4.5 7.2 0.1 2.8 1 1 3 4 4 4 0 Domain of unknown function (DUF4919) PTR2 PF00854.21 EEA25024.1 - 4.1e-67 226.7 0.4 7.5e-67 225.9 0.3 1.4 1 1 0 1 1 1 1 POT family FAD_binding_4 PF01565.23 EEA25025.1 - 5.7e-28 97.4 3.2 9.4e-28 96.7 3.2 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA25025.1 - 1.4e-10 41.1 0.0 3e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like LigD_N PF13298.6 EEA25026.1 - 9.7e-37 125.5 0.0 2.3e-36 124.3 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase Ligase (LigD) Raffinose_syn PF05691.12 EEA25027.1 - 2.3e-51 174.5 2.7 7.4e-50 169.5 2.7 2.2 1 1 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 TMEM126 PF07114.11 EEA25027.1 - 0.11 11.9 0.0 0.57 9.5 0.0 2.0 2 0 0 2 2 2 0 Transmembrane protein 126 DUF1929 PF09118.11 EEA25028.1 - 5e-21 74.8 0.4 9.9e-21 73.8 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.6 EEA25028.1 - 5.1e-16 58.3 1.3 3e-08 33.6 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EEA25028.1 - 2.1e-13 49.6 0.0 2.1e-06 27.2 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EEA25028.1 - 1.2e-08 34.8 7.1 0.002 18.1 0.0 4.9 5 1 0 5 5 5 2 Galactose oxidase, central domain Glyoxal_oxid_N PF07250.11 EEA25028.1 - 1.4e-08 34.3 0.0 0.0069 15.6 0.1 2.9 2 1 0 2 2 2 2 Glyoxal oxidase N-terminus Kelch_2 PF07646.15 EEA25028.1 - 2.7e-06 27.1 5.4 0.048 13.6 0.0 4.5 4 2 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 EEA25028.1 - 0.002 18.4 0.0 0.12 12.7 0.0 3.6 3 0 0 3 3 3 1 Galactose oxidase, central domain FAD_binding_4 PF01565.23 EEA25028.1 - 0.0029 17.3 0.9 0.075 12.8 0.0 2.7 2 0 0 2 2 2 1 FAD binding domain R3H PF01424.22 EEA25029.1 - 4.6e-11 42.5 0.0 9.8e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 EEA25029.1 - 9.7e-07 28.7 58.7 4.1e-05 23.5 14.4 13.1 15 0 0 15 15 15 7 NF-X1 type zinc finger Glyco_hydro_92 PF07971.12 EEA25030.1 - 5.2e-143 477.3 0.6 6.4e-143 477.0 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EEA25030.1 - 1.3e-56 192.2 1.6 2.1e-56 191.5 1.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain MFS_1 PF07690.16 EEA25031.1 - 5.8e-40 137.3 43.0 5.8e-40 137.3 43.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Evr1_Alr PF04777.13 EEA25032.1 - 1.2e-25 89.8 2.8 3.2e-25 88.5 0.1 2.5 2 0 0 2 2 2 1 Erv1 / Alr family zf-LYAR PF08790.11 EEA25032.1 - 2.1e-14 53.1 2.9 7.3e-14 51.4 2.9 2.0 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger Bys1 PF04681.12 EEA25032.1 - 3.1e-07 30.5 0.3 8.4e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 Blastomyces yeast-phase-specific protein Aminotran_4 PF01063.19 EEA25033.1 - 1.1e-29 103.9 0.0 1.4e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Aminotran_4 PF01063.19 EEA25034.1 - 1.1e-29 103.9 0.0 1.4e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV CAP59_mtransfer PF11735.8 EEA25035.1 - 0.071 12.8 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 Asp PF00026.23 EEA25036.1 - 0.015 14.7 1.3 0.019 14.4 1.3 1.2 1 0 0 1 1 1 0 Eukaryotic aspartyl protease RVT_2 PF07727.14 EEA25038.1 - 3.2e-07 30.3 0.0 5.9e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA25038.1 - 5.7e-06 26.5 0.0 1.6e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Cas_NE0113 PF09623.10 EEA25039.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein NE0113 (Cas_NE0113) DUF5401 PF17380.2 EEA25039.1 - 0.26 9.3 4.4 0.35 8.9 4.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) RVT_2 PF07727.14 EEA25040.1 - 9e-26 91.0 0.0 4.6e-16 59.2 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA25040.1 - 4.5e-08 32.8 0.1 1.4e-07 31.3 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA25040.1 - 3.3e-07 30.5 0.1 1e-05 25.7 0.0 2.8 3 0 0 3 3 3 1 Integrase core domain rve_3 PF13683.6 EEA25040.1 - 0.0013 18.5 3.9 0.11 12.3 0.0 3.4 3 0 0 3 3 3 2 Integrase core domain DUF4160 PF13711.6 EEA25040.1 - 0.12 12.7 0.2 0.68 10.3 0.2 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) Mannosidase_ig PF17786.1 EEA25042.1 - 1.3e-13 51.3 0.0 8e-13 48.8 0.0 2.2 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EEA25042.1 - 7.6e-08 33.0 0.0 2.9e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EEA25042.1 - 0.028 14.3 0.1 0.24 11.3 0.0 2.5 3 1 0 3 3 3 0 Glycosyl hydrolases family 2, sugar binding domain ATP11 PF06644.11 EEA25044.1 - 9.6e-102 340.4 0.0 1.1e-101 340.2 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein CCDC24 PF15669.5 EEA25044.1 - 0.08 12.8 1.3 0.14 12.1 1.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family FAM60A PF15396.6 EEA25044.1 - 0.13 12.3 0.4 0.18 11.8 0.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Herpes_pp85 PF04637.12 EEA25044.1 - 1.4 7.2 3.8 2 6.7 3.8 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Hydrolase_4 PF12146.8 EEA25045.1 - 1.3e-14 54.0 0.0 1.5e-10 40.8 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA25045.1 - 4.9e-12 46.0 0.0 7e-08 32.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA25045.1 - 9.6e-07 29.6 0.0 1e-05 26.3 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.12 EEA25045.1 - 1.6e-05 23.8 0.0 0.031 13.0 0.1 2.9 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) FSH1 PF03959.13 EEA25045.1 - 4.4e-05 23.3 0.0 0.00016 21.4 0.0 1.9 2 1 0 2 2 2 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 EEA25045.1 - 0.00014 21.9 0.0 0.037 14.0 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 EEA25045.1 - 0.00017 21.2 0.0 0.0056 16.3 0.0 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DUF818 PF05677.12 EEA25045.1 - 0.00029 19.9 0.0 0.00038 19.5 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) DLH PF01738.18 EEA25045.1 - 0.0004 20.0 0.0 0.0072 15.9 0.0 2.2 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EEA25045.1 - 0.00065 19.2 0.0 0.0066 15.9 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EEA25045.1 - 0.0037 17.1 0.0 0.0078 16.1 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA25045.1 - 0.0086 15.8 0.0 0.075 12.7 0.0 2.2 1 1 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EEA25045.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 EEA25045.1 - 0.025 14.2 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF2974 PF11187.8 EEA25045.1 - 0.11 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Proteasome PF00227.26 EEA25046.1 - 4.3e-48 163.3 0.3 4.9e-48 163.1 0.3 1.0 1 0 0 1 1 1 1 Proteasome subunit Cyclin PF08613.11 EEA25047.1 - 3.3e-37 128.4 8.4 7.3e-24 85.0 0.6 2.7 3 0 0 3 3 3 2 Cyclin PrpF PF04303.13 EEA25049.1 - 5e-86 289.0 0.3 5.6e-86 288.8 0.3 1.0 1 0 0 1 1 1 1 PrpF protein MFS_1 PF07690.16 EEA25050.1 - 8.5e-30 103.9 53.0 2e-25 89.5 33.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA25050.1 - 8.6e-20 71.0 25.6 2.4e-19 69.6 25.6 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter p450 PF00067.22 EEA25052.1 - 1.4e-22 80.1 0.0 2.5e-07 29.8 0.0 3.1 2 1 1 3 3 3 3 Cytochrome P450 MFS_1 PF07690.16 EEA25053.1 - 2.2e-11 43.3 2.8 2.4e-11 43.2 2.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Intg_mem_TP0381 PF09529.10 EEA25053.1 - 0.038 13.5 1.5 0.056 13.0 1.5 1.2 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) ABC_tran PF00005.27 EEA25054.1 - 3e-35 121.7 0.0 4e-24 85.7 0.0 3.0 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EEA25054.1 - 3.6e-25 89.1 6.0 3.6e-25 89.1 6.0 3.6 3 1 1 4 4 4 1 ABC transporter transmembrane region SMC_N PF02463.19 EEA25054.1 - 3.9e-06 26.5 1.4 0.084 12.3 0.0 3.2 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA25054.1 - 0.0026 17.6 0.2 5.7 6.7 0.1 3.3 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EEA25054.1 - 0.0056 16.9 0.3 0.55 10.5 0.2 3.0 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.17 EEA25054.1 - 0.012 15.3 0.3 0.38 10.5 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 EEA25054.1 - 0.049 14.0 0.2 0.48 10.8 0.1 2.6 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EEA25054.1 - 0.05 12.7 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 EEA25054.1 - 0.056 13.7 0.0 0.28 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 EEA25054.1 - 0.077 12.4 0.2 0.15 11.5 0.2 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_29 PF13555.6 EEA25054.1 - 0.18 11.6 0.7 0.41 10.4 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Phage_holin_5_2 PF16079.5 EEA25055.1 - 0.61 10.5 7.4 1.9 8.9 0.0 3.7 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V MFS_1 PF07690.16 EEA25055.1 - 4.5 6.1 24.6 0.12 11.2 18.0 1.8 2 0 0 2 2 2 0 Major Facilitator Superfamily RVT_1 PF00078.27 EEA25056.1 - 2.7e-28 99.0 0.0 4.8e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA25056.1 - 2e-21 76.0 0.0 6.7e-21 74.3 0.0 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EEA25056.1 - 1.2e-13 51.5 0.0 5.3e-13 49.4 0.0 2.2 2 0 0 2 2 2 1 RNase H Exo_endo_phos PF03372.23 EEA25056.1 - 3.4e-05 23.5 0.1 7.5e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF179 PF02622.15 EEA25057.1 - 0.018 15.0 0.1 0.047 13.7 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized ACR, COG1678 RVT_1 PF00078.27 EEA25059.1 - 7.3e-30 104.1 0.0 1.3e-29 103.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EEA25059.1 - 2e-22 79.2 0.1 5e-22 78.0 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EEA25059.1 - 1.8e-10 41.1 0.0 3.7e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 RNase H Exo_endo_phos PF03372.23 EEA25059.1 - 0.015 14.9 0.0 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Sfi1_C PF10638.9 EEA25059.1 - 0.047 14.4 0.1 0.12 13.1 0.1 1.6 1 0 0 1 1 1 0 Spindle body associated protein C-terminus DUF4300 PF14133.6 EEA25060.1 - 0.013 15.2 0.1 0.016 14.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) HsbA PF12296.8 EEA25060.1 - 0.082 13.3 0.2 0.11 12.9 0.2 1.2 1 0 0 1 1 1 0 Hydrophobic surface binding protein A RVT_2 PF07727.14 EEA25061.1 - 2.4e-13 50.3 0.0 4e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) OrsD PF12013.8 EEA25062.1 - 2.9e-12 47.0 9.6 2.9e-12 47.0 9.6 2.4 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA25062.1 - 3.4e-11 43.2 0.0 1.1e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA25062.1 - 0.00054 20.0 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_S8 PF00082.22 EEA25062.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Subtilase family zf-C2H2_12 PF18658.1 EEA25062.1 - 1.8 8.2 8.7 0.14 11.8 3.0 2.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type Integrase_H2C2 PF17921.1 EEA25063.1 - 8.4e-15 54.6 0.0 2.1e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EEA25063.1 - 1.8e-10 41.0 0.0 4.6e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 EEA25063.1 - 1.5e-07 31.2 0.6 3.9e-07 29.9 0.6 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EEA25063.1 - 0.0035 17.5 0.0 0.009 16.2 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger TORC_M PF12885.7 EEA25063.1 - 0.016 15.2 0.0 0.49 10.3 0.0 2.3 1 1 0 1 1 1 0 Transducer of regulated CREB activity middle domain HsbA PF12296.8 EEA25064.1 - 1.6e-15 57.6 0.1 1.3e-14 54.7 0.0 2.0 2 0 0 2 2 2 1 Hydrophobic surface binding protein A IL6 PF00489.17 EEA25065.1 - 0.073 12.6 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Glyco_hydro_18 PF00704.28 EEA25067.1 - 2.7e-49 168.6 0.4 7.3e-49 167.2 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EEA25067.1 - 0.0042 17.5 3.9 0.0042 17.5 3.9 3.4 2 1 0 2 2 2 1 Chitin recognition protein LysM PF01476.20 EEA25067.1 - 0.1 12.7 0.0 0.87 9.7 0.0 2.7 3 0 0 3 3 3 0 LysM domain Astacin PF01400.24 EEA25067.1 - 0.14 11.8 0.4 0.38 10.3 0.4 1.7 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) zf-CCCH_2 PF14608.6 EEA25067.1 - 1.4 9.5 5.0 6.7 7.4 0.2 2.9 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger p450 PF00067.22 EEA25068.1 - 1.4e-11 43.9 0.0 1.5e-11 43.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RVT_2 PF07727.14 EEA25069.1 - 3.1e-38 131.8 0.2 5.6e-38 131.0 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA25069.1 - 1.7e-07 31.0 0.7 4.6e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 GAG-pre-integrase domain rve PF00665.26 EEA25069.1 - 0.00054 20.1 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA25069.1 - 0.023 14.2 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Orthopox_F14 PF06076.12 EEA25069.1 - 0.11 12.8 3.2 0.3 11.4 3.2 1.8 1 0 0 1 1 1 0 Orthopoxvirus F14 protein REV1_C PF16727.5 EEA25069.1 - 1.2 9.6 3.6 16 5.9 0.3 2.7 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain LysM PF01476.20 EEA25070.1 - 0.061 13.4 1.7 0.24 11.5 0.1 2.7 3 0 0 3 3 3 0 LysM domain Asp PF00026.23 EEA25071.1 - 4.5e-52 177.4 0.0 5.4e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA25071.1 - 2e-06 28.3 0.0 0.046 14.4 0.1 3.1 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 EEA25071.1 - 8.7e-05 22.8 0.1 1.2 9.4 0.0 3.1 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EEA25071.1 - 0.055 14.0 0.0 16 6.1 0.0 3.2 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EEA25071.1 - 0.095 12.5 0.0 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal APH PF01636.23 EEA25072.1 - 3.8e-06 27.0 0.0 0.033 14.1 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EEA25072.1 - 0.11 11.7 0.1 0.25 10.5 0.0 1.6 2 0 0 2 2 2 0 Fructosamine kinase APH PF01636.23 EEA25074.1 - 4.7e-06 26.7 0.0 1.7e-05 24.9 0.0 1.9 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA25074.1 - 4.9e-06 26.3 0.0 0.00012 21.8 0.0 2.3 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 EEA25074.1 - 0.0025 17.2 0.0 0.0055 16.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EEA25074.1 - 0.032 13.6 0.0 0.059 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain WaaY PF06176.11 EEA25074.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Bys1 PF04681.12 EEA25075.1 - 0.085 12.8 0.0 0.097 12.6 0.0 1.2 1 0 0 1 1 1 0 Blastomyces yeast-phase-specific protein TSNAXIP1_N PF15739.5 EEA25076.1 - 0.02 15.3 0.1 0.048 14.0 0.1 1.7 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus SMK-1 PF04802.15 EEA25076.1 - 0.11 12.3 0.2 0.16 11.8 0.2 1.2 1 0 0 1 1 1 0 Component of IIS longevity pathway SMK-1 DLH PF01738.18 EEA25077.1 - 1.2e-10 41.3 0.0 1.4e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family ADIP PF11559.8 EEA25077.1 - 0.21 11.6 0.0 0.31 11.1 0.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DLH PF01738.18 EEA25078.1 - 8.9e-11 41.7 0.0 1e-10 41.5 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family ADIP PF11559.8 EEA25078.1 - 0.17 12.0 0.0 0.24 11.5 0.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DLH PF01738.18 EEA25079.1 - 4.1e-07 29.8 0.0 5.2e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family ADIP PF11559.8 EEA25079.1 - 0.22 11.6 0.0 0.29 11.2 0.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Asp PF00026.23 EEA25084.1 - 1.7e-42 146.0 0.7 2e-42 145.7 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease zf-BED PF02892.15 EEA25085.1 - 0.036 14.1 0.1 0.059 13.4 0.1 1.4 1 0 0 1 1 1 0 BED zinc finger Dimer_Tnp_hAT PF05699.14 EEA25086.1 - 9.2e-15 54.2 0.0 1.8e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Mrpl_C PF18502.1 EEA25086.1 - 0.001 19.3 1.8 0.008 16.4 1.8 2.3 2 1 0 2 2 2 1 54S ribosomal protein L8 C-terminal domain Helitron_like_N PF14214.6 EEA25086.1 - 0.13 12.5 0.5 0.21 11.8 0.5 1.2 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus Fungal_trans_2 PF11951.8 EEA25088.1 - 1.1e-16 60.7 0.9 1.1e-16 60.7 0.9 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25088.1 - 2.2e-07 30.9 9.2 5.8e-07 29.5 9.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 EEA25088.1 - 0.87 10.1 5.9 1.9 9.0 5.9 1.5 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Cu_amine_oxid PF01179.20 EEA25089.1 - 1.4e-126 422.7 6.2 1.7e-126 422.4 6.2 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EEA25089.1 - 1.3e-25 88.9 0.9 2.6e-25 88.0 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Asp PF00026.23 EEA25090.1 - 9.5e-55 186.2 0.2 1.1e-54 186.0 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA25090.1 - 9.1e-06 26.0 0.1 0.17 12.1 0.0 3.2 2 1 0 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA25090.1 - 0.028 15.1 0.6 16 6.2 0.1 3.1 2 1 0 2 2 2 0 Aspartyl protease HALZ PF02183.18 EEA25092.1 - 0.0012 19.0 4.6 0.0012 19.0 4.6 2.0 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF4201 PF13870.6 EEA25092.1 - 0.004 16.9 6.7 0.0064 16.3 6.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) FtsL PF04999.13 EEA25092.1 - 0.015 15.2 2.9 0.038 14.0 2.9 1.7 1 1 0 1 1 1 0 Cell division protein FtsL PRKG1_interact PF15898.5 EEA25092.1 - 0.028 15.3 3.6 0.028 15.3 3.6 1.6 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain UPF0242 PF06785.11 EEA25092.1 - 0.039 14.1 6.8 0.047 13.8 6.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TetR PF13972.6 EEA25092.1 - 0.044 13.5 3.1 0.069 12.9 3.1 1.4 1 0 0 1 1 1 0 Bacterial transcriptional repressor DUF4337 PF14235.6 EEA25092.1 - 0.05 13.7 2.9 0.073 13.2 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) V_ATPase_I PF01496.19 EEA25092.1 - 0.084 10.8 2.6 0.08 10.8 2.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5320 PF17253.2 EEA25092.1 - 0.12 13.5 1.6 0.2 12.7 1.2 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5320) Baculo_gp64 PF03273.13 EEA25092.1 - 0.12 11.2 0.5 0.13 11.0 0.5 1.0 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family DASH_Dam1 PF08653.10 EEA25092.1 - 0.13 12.1 0.7 0.13 12.1 0.7 1.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 betaPIX_CC PF16523.5 EEA25092.1 - 0.24 11.3 7.4 1.1 9.2 4.2 2.3 1 1 1 2 2 2 0 betaPIX coiled coil bZIP_1 PF00170.21 EEA25092.1 - 0.52 10.4 6.7 0.29 11.3 3.5 2.0 2 0 0 2 2 2 0 bZIP transcription factor JIP_LZII PF16471.5 EEA25092.1 - 0.55 10.4 6.8 0.12 12.6 3.3 1.8 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DivIC PF04977.15 EEA25092.1 - 0.66 9.8 5.9 1.7 8.5 5.9 1.8 1 1 0 1 1 1 0 Septum formation initiator BMFP PF04380.13 EEA25092.1 - 0.87 10.1 7.2 0.12 12.8 3.1 1.8 2 1 0 2 2 1 0 Membrane fusogenic activity SseC PF04888.12 EEA25092.1 - 1.4 8.4 3.1 1.9 8.0 3.1 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family APG6_N PF17675.1 EEA25092.1 - 3.2 8.3 17.2 13 6.3 17.2 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region AAA_23 PF13476.6 EEA25092.1 - 5.5 7.4 7.8 6.4 7.2 7.8 1.2 1 0 0 1 1 1 0 AAA domain Integrase_H2C2 PF17921.1 EEA25093.1 - 3.9e-06 26.9 0.0 7.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVP_2 PF08284.11 EEA25093.1 - 4.6e-05 23.2 0.0 8.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 EEA25093.1 - 0.031 14.5 0.0 0.076 13.2 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger gag-asp_proteas PF13975.6 EEA25093.1 - 0.032 14.8 0.0 0.061 13.9 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease rve PF00665.26 EEA25094.1 - 2.5e-10 40.6 0.1 7.3e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain APH PF01636.23 EEA25095.1 - 7.1e-07 29.4 0.0 7.8e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA25095.1 - 5e-06 26.3 0.0 6.4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EEA25095.1 - 0.00018 20.9 0.0 0.00021 20.7 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EEA25095.1 - 0.0021 17.5 0.0 0.0024 17.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.11 EEA25095.1 - 0.0031 17.2 0.0 0.0035 17.0 0.0 1.0 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Chromo PF00385.24 EEA25096.1 - 0.0049 16.7 0.0 0.0089 15.9 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SH3_2 PF07653.17 EEA25096.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain RT_RNaseH PF17917.1 EEA25097.1 - 8.3e-35 119.3 0.0 1.5e-34 118.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EEA25097.1 - 2.3e-30 105.8 0.3 3.6e-30 105.1 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EEA25097.1 - 8.8e-28 96.3 0.0 1.9e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EEA25097.1 - 4.8e-05 23.4 0.0 0.0003 20.8 0.0 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain RVP_2 PF08284.11 EEA25098.1 - 0.002 17.9 0.1 0.0031 17.3 0.1 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF3560 PF12083.8 EEA25098.1 - 0.011 15.8 5.5 0.024 14.8 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) DUF1635 PF07795.11 EEA25099.1 - 0.48 10.2 10.6 0.082 12.8 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) CheZ PF04344.13 EEA25099.1 - 0.66 9.9 7.6 9.1 6.1 0.0 2.8 1 1 2 3 3 3 0 Chemotaxis phosphatase, CheZ DUF1003 PF06210.11 EEA25099.1 - 6.4 6.9 9.1 19 5.4 9.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Asp PF00026.23 EEA25100.1 - 3e-56 191.2 0.0 3.7e-56 190.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA25100.1 - 0.0016 18.7 0.0 1.8 8.8 0.0 2.7 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA25100.1 - 0.038 14.6 0.1 30 5.3 0.0 3.1 2 1 0 2 2 2 0 Aspartyl protease Acetyltransf_1 PF00583.25 EEA25102.1 - 7.2e-08 32.7 0.0 1.4e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Pho86 PF11124.8 EEA25102.1 - 0.0012 18.4 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 SAM35 PF10806.8 EEA25102.1 - 0.0082 16.4 0.1 6.2 7.1 0.0 2.4 2 1 0 2 2 2 2 SAM35, subunit of SAM coomplex Acetyltransf_10 PF13673.7 EEA25102.1 - 0.046 13.7 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA25102.1 - 0.051 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA25102.1 - 0.1 13.0 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sugar_tr PF00083.24 EEA25103.1 - 5e-47 160.8 15.3 1.4e-46 159.3 15.3 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA25103.1 - 7.6e-19 67.8 26.9 7.6e-19 67.8 26.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily NAD_binding_8 PF13450.6 EEA25104.1 - 1.4e-12 47.7 0.0 2.5e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EEA25104.1 - 3.8e-08 33.1 0.0 5.8e-05 22.6 0.0 3.0 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EEA25104.1 - 0.0076 16.2 2.2 1.2 9.1 0.0 3.3 4 0 0 4 4 4 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EEA25104.1 - 0.017 14.4 0.0 0.081 12.1 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA25104.1 - 0.03 13.9 0.1 0.064 12.8 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Alanine_zipper PF11839.8 EEA25106.1 - 0.4 11.1 1.9 12 6.4 0.1 2.2 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein 2-Hacid_dh_C PF02826.19 EEA25108.1 - 2.9e-45 153.8 0.0 4.4e-45 153.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA25108.1 - 0.00014 21.5 0.0 0.00036 20.2 0.0 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 EEA25108.1 - 0.022 15.3 0.0 0.23 11.9 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_binding_7 PF13241.6 EEA25108.1 - 0.024 15.1 0.0 0.25 11.8 0.0 2.2 2 0 0 2 2 2 0 Putative NAD(P)-binding ELFV_dehydrog PF00208.21 EEA25108.1 - 0.061 13.0 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AA_permease_2 PF13520.6 EEA25109.1 - 2.3e-76 257.3 31.6 2.8e-76 257.0 31.6 1.1 1 0 0 1 1 1 1 Amino acid permease Asp PF00026.23 EEA25110.1 - 1e-47 163.1 0.1 1.2e-47 162.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA25110.1 - 0.0011 19.6 0.2 5 7.8 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 EEA25110.1 - 0.0041 17.4 0.0 0.26 11.5 0.0 2.7 2 1 1 3 3 3 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EEA25110.1 - 0.028 15.0 0.0 12 6.5 0.0 2.6 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease TPP_enzyme_N PF02776.18 EEA25111.1 - 5.2e-33 114.1 0.0 1.2e-32 112.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA25111.1 - 1.4e-17 63.7 0.0 5.8e-17 61.7 0.0 2.1 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EEA25111.1 - 3.3e-17 62.7 2.0 3.7e-16 59.3 0.1 3.1 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 EEA25111.1 - 0.016 14.9 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit TPP_enzyme_N PF02776.18 EEA25112.1 - 5.2e-33 114.1 0.0 1.2e-32 112.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA25112.1 - 1.4e-17 63.7 0.0 5.8e-17 61.7 0.0 2.1 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EEA25112.1 - 3.3e-17 62.7 2.0 3.7e-16 59.3 0.1 3.1 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 EEA25112.1 - 0.016 14.9 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Amidase PF01425.21 EEA25113.1 - 2e-97 327.0 0.0 2.2e-97 326.9 0.0 1.0 1 0 0 1 1 1 1 Amidase DIM1 PF02966.16 EEA25113.1 - 0.2 11.4 0.0 0.32 10.8 0.0 1.2 1 0 0 1 1 1 0 Mitosis protein DIM1 LigB PF02900.18 EEA25114.1 - 1.6e-30 106.1 0.0 2.1e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Fungal_trans PF04082.18 EEA25115.1 - 1.4e-14 53.8 0.7 2.3e-14 53.0 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25115.1 - 2e-07 31.0 9.7 3.9e-07 30.1 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HNH PF01844.23 EEA25115.1 - 0.01 16.0 0.1 0.33 11.1 0.1 2.5 2 0 0 2 2 2 0 HNH endonuclease FAD_binding_3 PF01494.19 EEA25116.1 - 1e-12 48.0 0.0 2.6e-12 46.7 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EEA25116.1 - 0.0023 17.0 0.0 0.12 11.4 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase Pyr_redox_2 PF07992.14 EEA25116.1 - 0.0063 15.8 0.1 0.013 14.7 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA25116.1 - 0.016 15.5 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Peptidase_M20 PF01546.28 EEA25117.1 - 2.9e-27 95.7 0.0 4.5e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EEA25117.1 - 0.0019 18.0 0.0 0.0054 16.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 M20_dimer PF07687.14 EEA25117.1 - 0.003 17.5 0.0 0.0061 16.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Fungal_trans PF04082.18 EEA25118.1 - 1.2e-19 70.4 0.5 2e-19 69.7 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DIM PF08194.12 EEA25118.1 - 0.064 13.5 1.0 0.11 12.7 0.1 1.9 2 0 0 2 2 2 0 DIM protein Zn_clus PF00172.18 EEA25118.1 - 0.79 9.9 3.8 0.3 11.3 1.1 1.6 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain 2-Hacid_dh_C PF02826.19 EEA25119.1 - 2.4e-42 144.3 0.0 3.4e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA25119.1 - 8.5e-20 70.8 0.2 1.3e-19 70.2 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA25119.1 - 7.6e-05 22.9 1.1 0.00012 22.3 0.2 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EEA25119.1 - 0.00022 21.7 0.1 0.00079 20.0 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 EEA25119.1 - 0.0019 18.3 0.6 0.0037 17.3 0.1 1.7 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EEA25119.1 - 0.0021 17.7 0.1 0.0047 16.5 0.0 1.7 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 EEA25119.1 - 0.021 15.3 0.2 0.12 12.8 0.0 2.1 2 0 0 2 2 2 0 XdhC Rossmann domain Sacchrp_dh_NADP PF03435.18 EEA25119.1 - 0.025 14.8 1.0 0.065 13.5 0.1 2.3 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EEA25119.1 - 0.1 12.7 0.1 1 9.4 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EEA25119.1 - 0.27 10.5 3.9 0.42 9.9 0.9 2.5 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Aldolase_II PF00596.21 EEA25120.1 - 8.2e-49 166.1 0.1 1e-48 165.8 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain NmrA PF05368.13 EEA25121.1 - 3.4e-31 108.6 0.0 4.4e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA25121.1 - 2.7e-11 43.7 0.0 7.4e-11 42.3 0.0 1.8 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EEA25121.1 - 3.4e-06 26.3 0.3 5.8e-06 25.5 0.3 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA25121.1 - 7.2e-06 25.6 0.0 0.0002 20.9 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EEA25121.1 - 2e-05 25.0 0.0 5.8e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EEA25121.1 - 0.00016 22.0 0.2 0.00033 20.9 0.2 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EEA25121.1 - 0.00066 19.9 0.1 0.0015 18.7 0.1 1.6 2 0 0 2 2 2 1 TrkA-N domain KR PF08659.10 EEA25121.1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 KR domain DapB_N PF01113.20 EEA25121.1 - 0.0045 17.1 0.3 0.0084 16.2 0.3 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 EEA25121.1 - 0.053 13.0 0.1 0.088 12.3 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase FAD_binding_3 PF01494.19 EEA25122.1 - 8.5e-29 100.9 0.0 2.4e-28 99.4 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA25122.1 - 1.3e-08 34.8 0.2 0.00034 20.3 0.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA25122.1 - 2.7e-06 27.5 0.2 9.1e-06 25.8 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA25122.1 - 3.3e-06 26.6 0.1 0.00011 21.6 0.0 2.4 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA25122.1 - 0.00022 20.5 0.3 0.00036 19.7 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 EEA25122.1 - 0.00032 19.8 0.0 0.039 13.0 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase Lycopene_cycl PF05834.12 EEA25122.1 - 0.0012 18.0 0.0 0.0069 15.5 0.1 2.1 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 EEA25122.1 - 0.002 18.7 0.0 0.01 16.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA25122.1 - 0.034 13.5 0.0 0.49 9.6 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EEA25122.1 - 0.056 12.1 0.0 0.14 10.8 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 EEA25122.1 - 0.15 11.3 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.18 EEA25122.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF455 PF04305.14 EEA25123.1 - 1.6e-97 325.9 0.1 2.1e-97 325.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Rieske PF00355.26 EEA25123.1 - 6.3e-06 26.1 0.0 1.4e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EEA25123.1 - 1.8e-05 24.6 0.0 5.3e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Asp PF00026.23 EEA25125.1 - 2.4e-42 145.5 0.0 3e-42 145.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Glyco_hydro_76 PF03663.14 EEA25126.1 - 1.4e-140 469.0 30.8 1.7e-140 468.7 30.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Ammonium_transp PF00909.21 EEA25127.1 - 1.5e-76 257.7 32.4 1.7e-76 257.5 32.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF1604 PF07713.13 EEA25127.1 - 0.23 11.3 0.5 12 5.8 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1604) HLH PF00010.26 EEA25130.1 - 1.4e-13 50.6 0.8 2.5e-13 49.7 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SR-25 PF10500.9 EEA25130.1 - 0.047 13.3 9.5 0.067 12.8 9.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TSC22 PF01166.18 EEA25130.1 - 0.14 12.5 1.7 0.19 12.1 0.3 1.9 2 0 0 2 2 2 0 TSC-22/dip/bun family XkdW PF09636.10 EEA25130.1 - 0.18 11.9 1.6 0.26 11.4 0.4 1.9 2 0 0 2 2 2 0 XkdW protein Glyco_hydro_28 PF00295.17 EEA25131.1 - 1e-46 159.5 11.2 1.4e-46 159.1 11.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 EEA25131.1 - 0.00026 20.9 18.0 0.00028 20.7 15.5 2.4 1 1 2 3 3 3 2 Right handed beta helix region DUF3224 PF11528.8 EEA25131.1 - 0.024 14.4 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3224) DLH PF01738.18 EEA25132.1 - 4.4e-25 88.5 0.3 5.4e-25 88.2 0.3 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EEA25132.1 - 0.0027 17.6 0.5 0.0082 16.1 0.0 1.9 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.11 EEA25132.1 - 0.02 14.2 0.0 0.038 13.3 0.0 1.4 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DLH PF01738.18 EEA25133.1 - 4.4e-25 88.5 0.3 5.4e-25 88.2 0.3 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EEA25133.1 - 0.0027 17.6 0.5 0.0082 16.1 0.0 1.9 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.11 EEA25133.1 - 0.02 14.2 0.0 0.038 13.3 0.0 1.4 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DLH PF01738.18 EEA25134.1 - 5.3e-12 45.8 0.1 7.3e-12 45.3 0.1 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EEA25134.1 - 0.0078 16.2 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.11 EEA25134.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF1758 PF05585.12 EEA25134.1 - 0.19 11.5 0.0 0.32 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Glyco_hydro_3_C PF01915.22 EEA25135.1 - 2.8e-45 154.8 0.1 4.3e-45 154.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA25135.1 - 4.4e-28 98.6 0.0 8.6e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA25135.1 - 3.7e-06 27.0 0.0 8.3e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.11 EEA25135.1 - 0.04 14.2 0.1 0.17 12.2 0.0 2.0 2 0 0 2 2 2 0 CARDB DDR PF08841.10 EEA25135.1 - 0.057 12.4 0.0 0.14 11.1 0.0 1.5 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain SnoaL_2 PF12680.7 EEA25136.1 - 2.9e-06 27.9 0.0 5.7e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EEA25136.1 - 3.6e-05 23.6 0.0 6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase AMP-binding PF00501.28 EEA25137.1 - 1e-71 241.8 0.0 1.5e-71 241.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EEA25137.1 - 2.4e-60 203.9 0.0 5e-60 202.8 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.25 EEA25137.1 - 9.7e-53 178.5 2.4 1.9e-52 177.6 2.4 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25137.1 - 3.8e-40 137.9 2.5 4e-40 137.8 1.3 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA25137.1 - 1.1e-16 61.2 1.9 5e-13 49.3 1.1 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EEA25137.1 - 4.4e-14 52.5 0.0 2e-07 30.8 0.0 2.8 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA25137.1 - 8.9e-11 42.0 0.0 2.3e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EEA25137.1 - 3.6e-10 39.3 0.2 3.1e-06 26.4 0.0 3.2 3 0 0 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EEA25137.1 - 1.7e-08 33.9 0.1 1.1e-05 24.7 0.0 3.1 2 1 0 2 2 2 2 RmlD substrate binding domain NAD_binding_10 PF13460.6 EEA25137.1 - 3.4e-07 30.3 0.5 4e-05 23.6 0.4 3.4 4 0 0 4 4 4 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EEA25137.1 - 0.00012 21.3 4.9 0.018 14.2 0.3 3.1 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EEA25137.1 - 0.0019 17.7 0.2 1.8 7.9 0.0 2.3 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase DFP PF04127.15 EEA25137.1 - 0.017 14.9 1.1 0.061 13.1 1.1 1.9 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NmrA PF05368.13 EEA25137.1 - 4.3 6.8 5.0 5.8 6.4 1.6 2.8 4 1 0 4 4 4 0 NmrA-like family Aa_trans PF01490.18 EEA25138.1 - 2.8e-51 174.5 41.2 3.2e-51 174.3 41.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein COX2_TM PF02790.15 EEA25138.1 - 0.0055 16.8 1.6 0.0055 16.8 1.6 3.3 3 0 0 3 3 3 1 Cytochrome C oxidase subunit II, transmembrane domain ATG27 PF09451.10 EEA25138.1 - 0.063 13.1 0.3 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 adh_short PF00106.25 EEA25139.1 - 6.5e-34 117.1 0.1 7.6e-34 116.9 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25139.1 - 1.4e-29 103.3 0.1 1.8e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA25139.1 - 3.5e-10 40.1 0.1 6.5e-10 39.2 0.1 1.4 1 1 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EEA25139.1 - 0.011 15.1 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EEA25139.1 - 0.012 15.1 0.1 0.017 14.6 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Oxidored_FMN PF00724.20 EEA25141.1 - 1.4e-73 248.1 0.0 2.1e-73 247.6 0.0 1.3 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF1848 PF08902.11 EEA25141.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) Oxidored_FMN PF00724.20 EEA25142.1 - 2e-58 198.3 0.0 2.6e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF1848 PF08902.11 EEA25142.1 - 0.069 12.9 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) Arrestin_C PF02752.22 EEA25143.1 - 2.9e-05 24.5 0.1 0.038 14.4 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EEA25143.1 - 0.015 15.3 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EEA25144.1 - 0.00017 22.1 0.0 0.39 11.2 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EEA25144.1 - 0.0096 16.0 0.0 0.019 15.0 0.0 1.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Glyco_hydro_30 PF02055.16 EEA25146.1 - 3.4e-34 118.4 7.5 6.1e-34 117.5 7.5 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 EEA25146.1 - 2.9e-08 33.8 0.2 8.8e-08 32.3 0.2 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 EEA25146.1 - 1e-05 24.9 3.8 2.7e-05 23.5 3.7 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 59 Collar PF07484.12 EEA25146.1 - 0.0087 16.1 0.2 0.024 14.6 0.2 1.8 1 0 0 1 1 1 1 Phage Tail Collar Domain RTA1 PF04479.13 EEA25147.1 - 2.4e-56 190.6 12.1 3.5e-56 190.1 12.1 1.2 1 0 0 1 1 1 1 RTA1 like protein Mucin PF01456.17 EEA25147.1 - 7.3 6.6 18.4 0.61 10.1 1.2 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein TRAM_LAG1_CLN8 PF03798.16 EEA25148.1 - 1.5e-34 119.5 15.4 2.8e-34 118.6 15.4 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EEA25148.1 - 1.2e-21 76.1 2.4 1.5e-21 75.8 0.6 2.2 2 0 0 2 2 2 1 TRAM1-like protein FMO-like PF00743.19 EEA25149.1 - 1.8e-20 72.9 0.0 8.6e-20 70.6 0.0 1.9 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA25149.1 - 5e-13 49.0 0.0 3.7e-09 36.3 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA25149.1 - 4.6e-09 35.9 0.0 2.6e-08 33.4 0.0 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA25149.1 - 1.1e-08 34.7 0.0 1.1e-05 24.8 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EEA25149.1 - 2.8e-05 24.2 0.6 8.3e-05 22.7 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EEA25149.1 - 0.00013 21.4 0.0 0.064 12.5 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EEA25149.1 - 0.00029 20.9 0.4 0.072 13.1 0.1 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EEA25149.1 - 0.0015 19.0 1.7 0.26 11.9 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EEA25149.1 - 0.0023 17.8 0.1 0.0037 17.2 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 EEA25149.1 - 0.0023 17.6 2.5 0.0055 16.3 0.3 2.5 3 1 0 4 4 4 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EEA25149.1 - 0.0027 17.8 0.0 5 7.2 0.0 3.0 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EEA25149.1 - 0.15 10.8 0.8 1.4 7.6 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 EEA25149.1 - 0.99 8.4 3.6 0.25 10.4 0.3 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A PCI PF01399.27 EEA25150.1 - 0.0056 17.2 0.0 1.9 9.1 0.0 2.8 2 0 0 2 2 2 2 PCI domain 5_nucleotid_C PF02872.18 EEA25151.1 - 5.2e-40 137.3 0.0 1e-39 136.3 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EEA25151.1 - 2.3e-05 25.0 0.0 4.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FA_desaturase PF00487.24 EEA25153.1 - 0.04 13.8 10.8 0.017 14.9 8.5 1.4 1 1 0 1 1 1 0 Fatty acid desaturase TRP PF06011.12 EEA25155.1 - 7.1e-145 483.0 35.3 8.6e-145 482.7 35.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EEA25155.1 - 1.2e-36 126.1 0.9 1.9e-36 125.5 0.9 1.3 1 0 0 1 1 1 1 ML-like domain CFEM PF05730.11 EEA25156.1 - 6.3e-13 48.6 10.2 6.8e-13 48.5 9.2 1.6 1 1 0 1 1 1 1 CFEM domain DUF2892 PF11127.8 EEA25156.1 - 1.9 8.6 0.0 1.9 8.6 0.0 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF2892) Ldh_2 PF02615.14 EEA25158.1 - 4.7e-127 423.7 0.3 5.3e-127 423.6 0.3 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Quaking_NLS PF16551.5 EEA25158.1 - 0.06 13.0 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Putative nuclear localisation signal of quaking adh_short_C2 PF13561.6 EEA25159.1 - 8.5e-53 179.3 0.4 1.1e-52 178.9 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA25159.1 - 2.3e-37 128.4 1.7 3.1e-37 128.0 1.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Dabb PF07876.12 EEA25160.1 - 0.00029 21.4 0.0 0.00035 21.1 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain WBS28 PF15164.6 EEA25161.1 - 0.075 12.3 2.0 0.45 9.8 0.0 2.1 2 0 0 2 2 2 0 Williams-Beuren syndrome chromosomal region 28 protein homologue Abhydrolase_1 PF00561.20 EEA25163.1 - 1.6e-15 57.5 0.0 7.4e-11 42.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA25163.1 - 3.8e-11 42.7 0.0 9.4e-11 41.4 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA25163.1 - 4.7e-05 23.3 0.0 0.098 12.4 0.0 3.0 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EEA25163.1 - 6.2e-05 23.7 0.0 7.8e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 EEA25163.1 - 0.0029 16.3 0.0 0.0075 15.0 0.0 1.6 2 0 0 2 2 2 1 Ndr family Peptidase_S9 PF00326.21 EEA25163.1 - 0.027 13.9 0.0 6.2 6.2 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EEA25163.1 - 0.056 13.0 0.0 0.089 12.4 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) peroxidase PF00141.23 EEA25164.1 - 2.4e-42 145.2 0.0 3.6e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 Peroxidase MFAP1 PF06991.11 EEA25165.1 - 0.00096 19.1 1.4 0.0012 18.8 1.4 1.1 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing Amidohydro_1 PF01979.20 EEA25166.1 - 4e-36 125.0 0.7 5.3e-31 108.2 0.1 2.0 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 EEA25166.1 - 1.4e-07 31.4 0.2 0.00028 20.5 0.0 3.0 1 1 0 2 2 2 2 Amidohydrolase family HMGL-like PF00682.19 EEA25166.1 - 0.02 14.5 0.2 0.033 13.8 0.2 1.3 1 0 0 1 1 1 0 HMGL-like KRBA1 PF15287.6 EEA25166.1 - 0.12 12.1 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 KRBA1 family repeat T2SSF PF00482.23 EEA25166.1 - 0.13 12.2 0.4 1.1 9.3 0.0 2.4 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F Cu-oxidase_3 PF07732.15 EEA25167.1 - 2.6e-27 95.2 0.8 9.7e-27 93.3 0.0 2.5 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EEA25167.1 - 5.8e-24 85.0 0.2 1.7e-23 83.5 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA25167.1 - 2.7e-20 72.5 12.4 3e-18 65.9 4.0 4.6 4 2 0 4 4 4 2 Multicopper oxidase DUF2703 PF10865.8 EEA25167.1 - 0.2 11.8 0.0 0.42 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) AMP-binding PF00501.28 EEA25168.1 - 3.6e-32 111.5 0.0 1.2e-31 109.8 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EEA25168.1 - 3.2e-24 85.5 0.0 4.6e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EEA25168.1 - 5.9e-07 29.2 0.0 3.1e-06 26.8 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA25168.1 - 1.2e-06 28.8 1.0 4e-06 27.1 0.0 2.6 3 0 0 3 3 3 1 Phosphopantetheine attachment site KR PF08659.10 EEA25168.1 - 3.3e-05 23.9 0.2 0.00017 21.6 0.0 2.2 2 0 0 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 EEA25168.1 - 0.00057 19.4 0.0 0.12 11.8 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EEA25168.1 - 0.077 12.1 0.0 0.19 10.9 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA25169.1 - 1.9e-20 73.4 0.0 2.7e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA25169.1 - 5.7e-14 51.8 0.0 8e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA25169.1 - 9.7e-10 38.4 0.0 1.8e-09 37.5 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EEA25169.1 - 5.2e-09 35.6 0.0 6.6e-08 32.0 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EEA25169.1 - 1.3e-08 34.9 0.0 1.9e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EEA25169.1 - 1.7e-05 24.8 0.0 2.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA25169.1 - 0.00016 20.9 0.0 0.00027 20.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EEA25169.1 - 0.00024 20.6 0.0 0.00067 19.2 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase F420_oxidored PF03807.17 EEA25169.1 - 0.0013 19.3 0.0 0.0029 18.1 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 EEA25169.1 - 0.01 15.4 0.1 0.028 14.0 0.1 1.8 2 1 0 2 2 2 0 NmrA-like family RmlD_sub_bind PF04321.17 EEA25169.1 - 0.09 11.9 0.1 0.2 10.7 0.1 1.7 1 1 0 1 1 1 0 RmlD substrate binding domain DIOX_N PF14226.6 EEA25170.1 - 1.4e-28 100.0 0.0 2e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA25170.1 - 4.9e-21 75.1 0.0 1.3e-20 73.8 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EEA25171.1 - 8.6e-28 97.3 48.6 3.6e-27 95.2 46.0 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Methyltransf_2 PF00891.18 EEA25172.1 - 1.4e-22 80.1 0.0 2.2e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EEA25172.1 - 0.00015 22.4 0.0 0.00052 20.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA25172.1 - 0.0013 19.5 0.0 0.0028 18.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA25172.1 - 0.0013 18.5 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF1731 PF08338.11 EEA25172.1 - 0.046 13.5 0.0 0.36 10.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1731) CheR PF01739.18 EEA25172.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_11 PF08241.12 EEA25172.1 - 0.09 13.4 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ketoacyl-synt PF00109.26 EEA25173.1 - 7.5e-73 245.2 0.1 1.8e-72 244.0 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EEA25173.1 - 3.7e-32 110.8 0.0 7.4e-32 109.8 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain HTH_51 PF18558.1 EEA25173.1 - 9.6e-28 95.9 0.0 2.8e-27 94.4 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain PP-binding PF00550.25 EEA25173.1 - 6.3e-23 80.9 8.7 2.1e-12 47.2 0.8 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 EEA25173.1 - 8e-23 81.1 0.2 1.3e-22 80.4 0.2 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EEA25173.1 - 1.1e-19 71.1 0.0 2.1e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Abhydrolase_3 PF07859.13 EEA25173.1 - 4.4e-13 49.6 0.0 2.8e-09 37.2 0.0 3.0 3 0 0 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA25173.1 - 4.1e-09 36.2 0.0 1e-05 25.1 0.0 2.5 2 0 0 2 2 2 2 Prolyl oligopeptidase family KAsynt_C_assoc PF16197.5 EEA25173.1 - 7.2e-09 36.1 0.0 2.9e-08 34.2 0.0 2.1 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 EEA25173.1 - 7.1e-07 29.2 0.1 1.5e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA25173.1 - 7.2e-06 26.7 0.0 2e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Abhydrolase_6 PF12697.7 EEA25173.1 - 9.9e-06 26.3 1.5 0.00016 22.3 0.3 2.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 EEA25173.1 - 4.2e-05 23.2 0.0 0.019 14.5 0.0 2.5 2 0 0 2 2 2 2 Dienelactone hydrolase family Thiolase_N PF00108.23 EEA25173.1 - 0.00015 21.3 0.1 0.00034 20.0 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 EEA25173.1 - 0.00081 20.0 0.0 0.0059 17.2 0.0 2.6 3 0 0 3 3 1 1 Methyltransferase domain Abhydrolase_2 PF02230.16 EEA25173.1 - 0.0019 18.1 0.0 0.85 9.4 0.0 2.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Methyltransf_25 PF13649.6 EEA25173.1 - 0.0048 17.6 0.1 0.032 14.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Hydrolase_4 PF12146.8 EEA25173.1 - 0.061 12.6 0.1 0.78 9.0 0.0 2.6 3 0 0 3 3 3 0 Serine aminopeptidase, S33 AXE1 PF05448.12 EEA25173.1 - 0.092 11.4 0.0 0.19 10.4 0.0 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Methyltransf_31 PF13847.6 EEA25173.1 - 0.13 12.0 0.0 0.51 10.1 0.0 2.0 2 0 0 2 2 1 0 Methyltransferase domain FAD_binding_4 PF01565.23 EEA25174.1 - 1.5e-20 73.3 1.0 2.3e-20 72.8 1.0 1.2 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA25174.1 - 3.6e-05 23.8 0.0 7.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like p450 PF00067.22 EEA25175.1 - 1.2e-67 228.7 0.0 1.6e-67 228.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Myb_DNA-binding PF00249.31 EEA25176.1 - 5.1e-31 106.6 14.2 1.8e-10 40.8 0.9 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA25176.1 - 1.7e-28 98.7 6.6 1.1e-12 48.0 1.1 3.5 1 1 2 3 3 3 3 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 EEA25176.1 - 1.5e-05 25.2 7.6 0.11 12.9 1.1 3.3 2 1 1 3 3 3 2 Alcohol dehydrogenase transcription factor Myb/SANT-like SLIDE PF09111.10 EEA25176.1 - 0.037 14.0 0.2 0.69 10.0 0.1 2.8 1 1 2 3 3 3 0 SLIDE SANT_DAMP1_like PF16282.5 EEA25176.1 - 0.043 14.0 0.8 13 6.1 0.1 2.4 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 CHAD PF05235.14 EEA25176.1 - 0.061 13.3 4.0 0.097 12.6 4.0 1.2 1 0 0 1 1 1 0 CHAD domain Rap1_C PF11626.8 EEA25176.1 - 0.088 12.9 7.0 3.2 7.9 0.5 3.4 2 1 1 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_4 PF13837.6 EEA25176.1 - 0.091 13.1 10.5 5.9 7.3 0.8 3.5 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain FAD_binding_4 PF01565.23 EEA25177.1 - 3.4e-21 75.5 2.6 3.5e-21 75.4 0.3 2.2 3 0 0 3 3 3 1 FAD binding domain BBE PF08031.12 EEA25177.1 - 0.0033 17.5 0.0 0.043 13.9 0.0 2.3 2 0 0 2 2 2 1 Berberine and berberine like MFS_1 PF07690.16 EEA25178.1 - 5.1e-15 55.2 61.3 1.5e-09 37.3 42.3 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily ADH_zinc_N_2 PF13602.6 EEA25179.1 - 1.8e-26 93.7 0.0 3e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EEA25179.1 - 7.3e-15 55.1 0.0 1.3e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA25179.1 - 3.6e-07 30.0 0.0 1.4e-06 28.1 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.6 EEA25179.1 - 0.039 13.8 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding Abhydrolase_3 PF07859.13 EEA25180.1 - 4.9e-36 124.6 0.1 1.9e-25 89.9 0.1 3.1 2 1 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EEA25180.1 - 1.9e-15 56.7 0.0 3.3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 EEA25180.1 - 0.013 14.4 0.0 0.64 8.8 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family ParA PF10609.9 EEA25181.1 - 8.9e-86 287.3 0.1 5.2e-54 183.3 0.0 2.0 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EEA25181.1 - 3.4e-13 49.8 0.0 3.9e-10 39.9 0.0 2.2 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EEA25181.1 - 9.7e-10 38.6 0.1 2.5e-09 37.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 EEA25181.1 - 1.4e-06 27.8 0.1 2.4e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EEA25181.1 - 0.0002 20.7 0.2 0.0019 17.4 0.3 2.3 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.6 EEA25181.1 - 0.00054 19.6 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 EEA25181.1 - 0.005 16.3 0.0 0.071 12.5 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Ribosomal_S27e PF01667.17 EEA25181.1 - 0.014 15.1 0.1 0.027 14.1 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein S27 MeaB PF03308.16 EEA25181.1 - 0.053 12.5 0.2 0.088 11.8 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB VirC1 PF07015.11 EEA25181.1 - 0.056 12.7 0.1 0.086 12.1 0.1 1.2 1 0 0 1 1 1 0 VirC1 protein CBP_BcsQ PF06564.12 EEA25181.1 - 0.072 12.6 0.1 0.21 11.0 0.1 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 EEA25181.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_26 PF13500.6 EEA25181.1 - 0.12 12.2 0.4 6.2 6.6 0.4 2.2 2 0 0 2 2 2 0 AAA domain FTHFS PF01268.19 EEA25181.1 - 0.19 9.9 0.0 0.27 9.4 0.0 1.1 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase DUF1610 PF07754.11 EEA25181.1 - 0.37 10.8 2.7 0.76 9.8 2.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) ParA PF10609.9 EEA25182.1 - 8.9e-86 287.3 0.1 5.2e-54 183.3 0.0 2.0 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EEA25182.1 - 3.4e-13 49.8 0.0 3.9e-10 39.9 0.0 2.2 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EEA25182.1 - 9.7e-10 38.6 0.1 2.5e-09 37.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 EEA25182.1 - 1.4e-06 27.8 0.1 2.4e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EEA25182.1 - 0.0002 20.7 0.2 0.0019 17.4 0.3 2.3 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.6 EEA25182.1 - 0.00054 19.6 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 EEA25182.1 - 0.005 16.3 0.0 0.071 12.5 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Ribosomal_S27e PF01667.17 EEA25182.1 - 0.014 15.1 0.1 0.027 14.1 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein S27 MeaB PF03308.16 EEA25182.1 - 0.053 12.5 0.2 0.088 11.8 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB VirC1 PF07015.11 EEA25182.1 - 0.056 12.7 0.1 0.086 12.1 0.1 1.2 1 0 0 1 1 1 0 VirC1 protein CBP_BcsQ PF06564.12 EEA25182.1 - 0.072 12.6 0.1 0.21 11.0 0.1 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 EEA25182.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_26 PF13500.6 EEA25182.1 - 0.12 12.2 0.4 6.2 6.6 0.4 2.2 2 0 0 2 2 2 0 AAA domain FTHFS PF01268.19 EEA25182.1 - 0.19 9.9 0.0 0.27 9.4 0.0 1.1 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase DUF1610 PF07754.11 EEA25182.1 - 0.37 10.8 2.7 0.76 9.8 2.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) TRAUB PF08164.12 EEA25183.1 - 5.6e-32 110.1 0.1 2.9e-31 107.8 0.1 2.3 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EEA25183.1 - 3e-24 86.3 4.7 3e-24 86.3 4.7 3.0 3 2 0 3 3 3 1 Apoptosis antagonizing transcription factor DUF2433 PF10360.9 EEA25184.1 - 3.9e-49 165.9 0.0 8.2e-49 164.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos_2 PF12850.7 EEA25184.1 - 0.0012 19.0 0.0 0.0043 17.2 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EEA25184.1 - 0.0014 19.1 0.0 0.004 17.7 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PAP1 PF08601.10 EEA25185.1 - 8.1e-112 374.6 42.5 7e-103 345.2 12.9 4.0 3 1 1 4 4 4 2 Transcription factor PAP1 bZIP_1 PF00170.21 EEA25185.1 - 4e-09 36.4 10.7 1e-08 35.1 10.7 1.7 1 0 0 1 1 1 1 bZIP transcription factor DUF16 PF01519.16 EEA25185.1 - 0.0022 18.5 0.8 0.006 17.0 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function DUF16 EMP24_GP25L PF01105.24 EEA25185.1 - 0.018 15.0 0.5 0.035 14.0 0.5 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD SHE3 PF17078.5 EEA25185.1 - 0.019 14.7 3.4 0.046 13.4 3.4 1.6 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_2 PF07716.15 EEA25185.1 - 0.029 14.4 13.8 0.061 13.4 12.6 2.1 1 1 1 2 2 2 0 Basic region leucine zipper SlyX PF04102.12 EEA25185.1 - 0.082 13.5 0.4 0.27 11.9 0.4 1.9 1 0 0 1 1 1 0 SlyX PSI_PsaF PF02507.15 EEA25185.1 - 0.17 11.7 0.1 0.32 10.8 0.1 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III UPF0242 PF06785.11 EEA25185.1 - 2.2 8.4 6.9 5 7.2 6.9 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF812 PF05667.11 EEA25185.1 - 3 6.6 11.3 0.03 13.2 3.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF812) bZIP_Maf PF03131.17 EEA25185.1 - 5 7.7 16.9 0.16 12.5 10.1 2.0 2 0 0 2 2 2 0 bZIP Maf transcription factor PAP1 PF08601.10 EEA25186.1 - 1.1e-88 298.5 55.1 1.4e-70 238.9 2.3 5.0 3 1 2 5 5 5 3 Transcription factor PAP1 bZIP_1 PF00170.21 EEA25186.1 - 3.7e-09 36.5 10.7 9.7e-09 35.2 10.7 1.7 1 0 0 1 1 1 1 bZIP transcription factor DUF16 PF01519.16 EEA25186.1 - 0.002 18.6 0.8 0.0055 17.2 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function DUF16 EMP24_GP25L PF01105.24 EEA25186.1 - 0.016 15.1 0.4 0.032 14.2 0.4 1.5 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD SHE3 PF17078.5 EEA25186.1 - 0.017 14.8 3.4 0.043 13.5 3.4 1.6 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_2 PF07716.15 EEA25186.1 - 0.028 14.5 13.9 0.058 13.5 12.7 2.1 1 1 1 2 2 2 0 Basic region leucine zipper SlyX PF04102.12 EEA25186.1 - 0.08 13.6 0.4 0.25 12.0 0.4 1.9 1 0 0 1 1 1 0 SlyX PSI_PsaF PF02507.15 EEA25186.1 - 0.15 11.8 0.1 0.3 10.9 0.1 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III DUF5320 PF17253.2 EEA25186.1 - 0.28 12.3 1.2 0.77 10.9 1.2 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5320) UPF0242 PF06785.11 EEA25186.1 - 2.1 8.4 6.9 4.6 7.3 6.9 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_Maf PF03131.17 EEA25186.1 - 4.6 7.8 16.9 0.15 12.6 10.1 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor Tudor_3 PF18115.1 EEA25188.1 - 3.4e-08 33.2 0.0 5.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain SMN PF06003.12 EEA25188.1 - 3.4e-05 23.2 1.0 3.4e-05 23.2 1.0 1.8 1 1 1 2 2 2 1 Survival motor neuron protein (SMN) DUF4537 PF15057.6 EEA25188.1 - 0.00015 21.7 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) LBR_tudor PF09465.10 EEA25188.1 - 0.017 14.9 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Tudor_2 PF18104.1 EEA25188.1 - 0.023 14.4 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain TUDOR PF00567.24 EEA25188.1 - 0.031 14.3 0.0 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 Tudor domain DUF2730 PF10805.8 EEA25188.1 - 0.12 12.5 0.2 0.21 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Fis1_TPR_C PF14853.6 EEA25188.1 - 0.21 11.7 0.2 0.37 10.9 0.2 1.3 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat YbjQ_1 PF01906.17 EEA25190.1 - 1.1e-28 99.9 1.0 7.1e-28 97.3 0.4 2.0 2 0 0 2 2 2 1 Putative heavy-metal-binding Beta-lactamase PF00144.24 EEA25193.1 - 1.5e-50 172.3 0.0 2.1e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EEA25193.1 - 0.03 13.7 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase COesterase PF00135.28 EEA25194.1 - 1.6e-63 215.4 0.0 2.1e-63 215.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA25194.1 - 1.6e-05 24.9 0.3 0.03 14.2 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA25194.1 - 0.0014 18.1 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EEA25194.1 - 0.0087 15.7 0.0 0.27 10.8 0.0 2.3 2 0 0 2 2 2 1 Putative esterase MFS_1 PF07690.16 EEA25195.1 - 4.5e-30 104.8 29.9 4.5e-30 104.8 29.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EEA25195.1 - 0.0003 20.2 7.5 0.0003 20.2 7.5 1.9 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB DAO PF01266.24 EEA25196.1 - 7.8e-29 101.3 0.0 9.4e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA25196.1 - 0.00085 18.6 0.2 0.0015 17.8 0.2 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EEA25196.1 - 0.001 19.0 0.0 0.037 14.0 0.1 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EEA25196.1 - 0.025 14.8 1.3 0.064 13.5 0.5 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Amidase PF01425.21 EEA25198.1 - 1.1e-88 298.1 0.0 1.8e-88 297.5 0.0 1.3 1 0 0 1 1 1 1 Amidase Zn_clus PF00172.18 EEA25199.1 - 3e-07 30.4 13.0 7.9e-07 29.1 13.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt4 PF06093.13 EEA25199.1 - 1.3 9.2 7.8 1.8 8.7 6.5 1.9 2 0 0 2 2 2 0 Spt4/RpoE2 zinc finger Fungal_trans_2 PF11951.8 EEA25200.1 - 8.1e-23 80.8 1.9 2.7e-22 79.1 1.9 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Aldedh PF00171.22 EEA25201.1 - 7.1e-170 565.5 3.1 3.7e-163 543.3 0.1 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA25201.1 - 0.16 11.4 0.0 1.5 8.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) DAO PF01266.24 EEA25202.1 - 3e-37 129.0 0.0 3.8e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA25202.1 - 7e-06 25.5 0.0 1.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EEA25202.1 - 0.00045 20.4 0.6 0.00094 19.4 0.6 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA25202.1 - 0.0016 17.5 0.8 0.025 13.6 0.6 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EEA25202.1 - 0.045 13.8 1.5 0.21 11.6 0.6 2.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EEA25202.1 - 0.046 12.9 0.0 0.089 12.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA25202.1 - 0.1 11.8 0.0 1.4 8.0 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EEA25202.1 - 0.2 10.9 1.3 0.59 9.3 1.3 1.9 1 1 0 1 1 1 0 FAD binding domain Aminotran_3 PF00202.21 EEA25203.1 - 5.6e-53 180.1 1.1 1.1e-51 175.8 1.1 2.0 1 1 0 1 1 1 1 Aminotransferase class-III Cupin_3 PF05899.12 EEA25203.1 - 0.00031 20.4 0.2 0.00055 19.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.12 EEA25203.1 - 0.00041 20.1 0.0 0.00072 19.4 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ 3Beta_HSD PF01073.19 EEA25204.1 - 5.7e-19 68.2 0.2 1.7e-13 50.2 0.0 3.0 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA25204.1 - 1.2e-13 51.1 1.1 2.5e-09 37.0 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA25204.1 - 3.3e-06 26.5 1.0 5e-05 22.6 0.2 2.1 1 1 1 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 EEA25204.1 - 6.1e-05 22.3 0.0 0.033 13.3 0.0 2.1 1 1 0 2 2 2 2 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EEA25204.1 - 0.00011 21.8 1.8 0.015 14.7 0.2 2.1 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase KR PF08659.10 EEA25204.1 - 0.0032 17.4 0.1 1.5 8.7 0.2 2.2 1 1 1 2 2 2 2 KR domain NmrA PF05368.13 EEA25204.1 - 0.07 12.7 0.6 9.5 5.7 0.1 2.1 2 0 0 2 2 2 0 NmrA-like family MTD PF01993.18 EEA25204.1 - 0.11 11.8 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase NPC1_N PF16414.5 EEA25205.1 - 2.5e-84 282.7 6.1 4.2e-84 281.9 6.1 1.4 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 EEA25205.1 - 4.6e-81 273.1 10.3 1.8e-80 271.2 10.4 1.8 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EEA25205.1 - 3.2e-53 179.7 7.4 3.2e-53 179.7 7.4 3.3 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EEA25205.1 - 6.5e-06 25.3 9.4 6.5e-06 25.3 9.4 3.4 4 0 0 4 4 4 1 MMPL family Folate_rec PF03024.14 EEA25205.1 - 0.029 14.3 2.4 0.064 13.1 2.4 1.5 1 0 0 1 1 1 0 Folate receptor family HEAT PF02985.22 EEA25205.1 - 0.27 11.6 3.6 9.1 6.8 0.3 3.8 3 0 0 3 3 3 0 HEAT repeat Alpha-amylase PF00128.24 EEA25206.1 - 4.2e-58 197.5 3.2 6.2e-58 197.0 3.2 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain CBM_20 PF00686.19 EEA25206.1 - 4.8e-35 119.4 0.5 1.1e-34 118.2 0.5 1.7 1 0 0 1 1 1 1 Starch binding domain DUF1966 PF09260.11 EEA25206.1 - 3.2e-31 107.5 0.2 3.2e-31 107.5 0.2 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF1966) HEAT_2 PF13646.6 EEA25207.1 - 4.8e-20 71.7 3.3 0.00015 22.1 0.0 7.7 7 1 1 8 8 8 6 HEAT repeats HEAT PF02985.22 EEA25207.1 - 1.7e-18 65.1 2.9 0.0012 18.9 0.0 10.4 12 0 0 12 12 11 2 HEAT repeat HEAT_EZ PF13513.6 EEA25207.1 - 6.5e-18 64.8 7.6 6.3e-05 23.4 0.0 10.1 8 2 2 10 10 10 3 HEAT-like repeat Cnd1 PF12717.7 EEA25207.1 - 8.2e-12 45.5 0.4 0.00023 21.2 0.0 4.7 4 0 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 EEA25207.1 - 1.5e-07 31.2 0.0 6.8e-07 29.1 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EEA25207.1 - 5.2e-06 27.0 0.0 0.64 10.7 0.0 5.5 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region ParcG PF10274.9 EEA25207.1 - 9e-06 25.9 0.7 0.018 15.2 0.1 4.0 3 2 2 5 5 5 1 Parkin co-regulated protein Adaptin_N PF01602.20 EEA25207.1 - 1e-05 24.4 0.0 0.18 10.3 0.0 3.3 3 1 0 3 3 3 2 Adaptin N terminal region MMS19_C PF12460.8 EEA25207.1 - 2.3e-05 23.7 0.1 2.8 6.9 0.0 3.8 3 1 0 3 3 3 3 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.9 EEA25207.1 - 6.6e-05 23.1 2.1 7.4 6.8 0.0 5.9 5 1 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Tti2 PF10521.9 EEA25207.1 - 0.00025 20.7 0.2 5.1 6.5 0.0 4.5 4 1 1 5 5 5 2 Tti2 family DUF577 PF04510.12 EEA25207.1 - 0.0033 17.4 0.0 0.013 15.4 0.0 2.1 1 1 0 1 1 1 1 Family of unknown function (DUF577) CLASP_N PF12348.8 EEA25207.1 - 0.0046 16.5 0.0 0.65 9.5 0.0 3.3 3 0 0 3 3 3 1 CLASP N terminal UNC45-central PF11701.8 EEA25207.1 - 0.0078 16.2 0.4 0.17 11.8 0.3 3.1 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central RIX1 PF08167.12 EEA25207.1 - 0.0094 15.7 0.0 1.6 8.5 0.0 3.5 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Arm PF00514.23 EEA25207.1 - 0.02 14.9 0.2 32 4.8 0.0 5.0 5 0 0 5 5 3 0 Armadillo/beta-catenin-like repeat TPR_12 PF13424.6 EEA25208.1 - 2.1e-142 463.7 43.7 7e-19 67.9 0.4 8.5 1 1 9 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 EEA25208.1 - 8.9e-122 394.2 3.2 2.5e-12 46.2 0.0 10.6 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.28 EEA25208.1 - 1.9e-52 173.0 38.8 9.8e-06 25.2 0.4 11.1 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_7 PF13176.6 EEA25208.1 - 3.9e-44 145.5 12.6 0.0014 18.6 0.0 10.8 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_8 PF13181.6 EEA25208.1 - 4.1e-33 110.8 35.4 0.01 16.0 0.1 11.0 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA25208.1 - 5.3e-32 111.5 9.0 3.2e-10 39.9 0.3 5.5 2 1 3 5 5 5 4 MalT-like TPR region TPR_2 PF07719.17 EEA25208.1 - 1.6e-30 102.7 28.5 0.0034 17.4 0.1 11.2 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_14 PF13428.6 EEA25208.1 - 7.6e-21 73.0 10.1 1.1 10.2 0.0 10.7 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA25208.1 - 1.3e-20 73.7 16.6 0.0018 18.9 0.1 9.4 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_17 PF13431.6 EEA25208.1 - 4.1e-17 61.2 14.0 1.1 9.8 0.1 11.0 10 0 0 10 10 10 1 Tetratricopeptide repeat NB-ARC PF00931.22 EEA25208.1 - 1.7e-14 53.7 0.0 2.4e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain PNP_UDP_1 PF01048.20 EEA25208.1 - 9e-14 51.3 0.0 1.5e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 EEA25208.1 - 1.8e-07 31.7 0.0 4.6e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain TPR_21 PF09976.9 EEA25208.1 - 5.7e-07 29.4 26.4 3.5 7.3 0.0 9.7 3 2 6 10 10 10 1 Tetratricopeptide repeat-like domain TPR_19 PF14559.6 EEA25208.1 - 3.3e-06 27.5 20.5 0.77 10.3 0.3 7.2 6 1 1 7 7 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA25208.1 - 5.8e-06 26.4 11.4 1.2 9.4 0.0 6.2 2 1 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 EEA25208.1 - 1.7e-05 25.0 0.0 39 5.3 0.0 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat PPR PF01535.20 EEA25208.1 - 2.2e-05 24.4 10.4 99 3.5 0.0 9.0 9 0 0 9 9 9 0 PPR repeat DUF5344 PF17279.2 EEA25208.1 - 0.00011 22.8 0.4 21 5.8 0.0 5.8 6 0 0 6 6 6 0 Family of unknown function (DUF5344) DUF2225 PF09986.9 EEA25208.1 - 0.00011 22.0 13.3 1.5 8.5 0.4 5.1 1 1 4 5 5 5 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 EEA25208.1 - 0.00016 21.3 36.1 0.22 11.2 0.1 10.3 10 1 0 10 10 10 3 TPR repeat SPO22 PF08631.10 EEA25208.1 - 0.0012 18.4 3.1 3.6 7.0 0.0 5.6 5 1 0 5 5 5 1 Meiosis protein SPO22/ZIP4 like Phage_T4_Ndd PF06591.11 EEA25208.1 - 0.035 13.9 0.1 0.11 12.3 0.0 1.8 2 0 0 2 2 1 0 T4-like phage nuclear disruption protein (Ndd) TniB PF05621.11 EEA25208.1 - 0.037 13.4 0.0 0.65 9.4 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein RPN6_N PF18055.1 EEA25208.1 - 0.038 14.4 6.5 8.7 6.7 0.2 5.2 3 2 3 7 7 7 0 26S proteasome regulatory subunit RPN6 N-terminal domain NACHT PF05729.12 EEA25208.1 - 0.076 12.9 0.2 0.25 11.3 0.2 1.8 1 1 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EEA25208.1 - 0.15 12.3 0.0 0.73 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain Thymosin PF01290.20 EEA25208.1 - 0.19 11.5 0.0 41 4.0 0.0 4.2 4 0 0 4 4 4 0 Thymosin beta-4 family TPR_6 PF13174.6 EEA25208.1 - 0.29 11.9 43.5 3.7 8.4 0.2 10.1 10 0 0 10 10 10 0 Tetratricopeptide repeat B1 PF02246.15 EEA25208.1 - 0.42 10.7 2.0 75 3.5 0.0 4.4 6 0 0 6 6 4 0 Protein L b1 domain ABC2_membrane PF01061.24 EEA25209.1 - 1.1e-78 263.5 52.0 8e-45 152.8 17.4 3.0 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EEA25209.1 - 7.5e-43 146.3 0.0 1.7e-20 74.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EEA25209.1 - 2.8e-22 78.4 14.6 5.5e-22 77.5 0.1 3.5 4 0 0 4 4 3 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EEA25209.1 - 1.6e-08 34.0 21.8 3.8e-07 29.5 10.7 2.6 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 EEA25209.1 - 7e-07 29.8 0.0 0.0011 19.4 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EEA25209.1 - 4.4e-06 26.7 0.0 0.12 12.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA25209.1 - 2.1e-05 24.5 0.0 0.00044 20.2 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EEA25209.1 - 0.0011 18.7 0.1 0.034 13.9 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EEA25209.1 - 0.0028 18.2 0.0 0.37 11.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA25209.1 - 0.006 16.9 0.0 0.67 10.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EEA25209.1 - 0.01 15.9 0.0 5.9 7.0 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 EEA25209.1 - 0.02 14.8 0.1 0.69 9.8 0.1 2.7 3 0 0 3 3 3 0 NACHT domain AAA_33 PF13671.6 EEA25209.1 - 0.039 14.1 0.0 0.42 10.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EEA25209.1 - 0.042 13.4 0.0 0.72 9.4 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EEA25209.1 - 0.052 13.8 0.5 0.39 10.9 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA25209.1 - 0.073 12.6 0.1 0.32 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain TMIE PF16038.5 EEA25209.1 - 0.083 12.7 0.5 0.23 11.3 0.0 2.0 2 0 0 2 2 1 0 TMIE protein AAA_30 PF13604.6 EEA25209.1 - 0.11 12.2 0.0 2 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EEA25209.1 - 0.17 11.6 0.0 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FAD_binding_4 PF01565.23 EEA25210.1 - 1.8e-22 79.6 3.3 2.8e-22 79.0 3.3 1.3 1 0 0 1 1 1 1 FAD binding domain Herpes_UL49_5 PF05702.11 EEA25210.1 - 0.19 11.8 0.3 0.39 10.8 0.3 1.4 1 0 0 1 1 1 0 Herpesvirus UL49.5 envelope/tegument protein Metallophos PF00149.28 EEA25211.1 - 2.3e-28 100.1 2.1 4.3e-28 99.2 2.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EEA25211.1 - 4.8e-16 59.4 0.4 4.8e-16 59.4 0.4 2.2 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EEA25211.1 - 6.5e-13 49.1 0.1 1.6e-12 47.8 0.1 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 EEA25211.1 - 0.035 14.6 0.1 0.076 13.5 0.1 1.6 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain Ank_2 PF12796.7 EEA25212.1 - 5.2e-60 200.0 12.9 1.1e-13 51.6 0.1 4.8 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA25212.1 - 2.2e-42 142.9 14.1 2.1e-08 34.5 0.1 5.6 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA25212.1 - 4.4e-35 115.7 4.8 0.00041 20.6 0.0 7.2 7 0 0 7 7 7 7 Ankyrin repeat Ank PF00023.30 EEA25212.1 - 2e-31 107.0 16.9 1.6e-05 25.1 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 EEA25212.1 - 1.7e-26 91.9 13.9 7.6e-05 22.9 0.1 7.1 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Erythro-docking PF09277.11 EEA25212.1 - 0.09 12.7 1.4 2.1 8.3 0.1 3.4 4 0 0 4 4 4 0 Erythronolide synthase, docking Glyco_hydro_25 PF01183.20 EEA25213.1 - 2.5e-41 141.8 0.8 2.8e-41 141.6 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 OPT PF03169.15 EEA25214.1 - 1.2e-163 546.1 56.7 1.3e-163 545.9 56.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DAO PF01266.24 EEA25215.1 - 7.8e-27 94.8 0.2 1.2e-26 94.1 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fungal_trans PF04082.18 EEA25215.1 - 6.5e-21 74.5 0.0 1.5e-20 73.3 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25215.1 - 5.9e-09 35.9 6.7 1.4e-08 34.7 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 EEA25215.1 - 0.00096 18.5 0.1 0.0015 17.8 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA25215.1 - 0.0011 19.2 1.1 0.0051 17.0 0.4 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EEA25215.1 - 0.0029 17.2 0.9 0.0058 16.3 0.9 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 EEA25215.1 - 0.0077 15.4 0.5 0.013 14.7 0.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Ehbp PF10622.9 EEA25215.1 - 0.048 13.7 0.3 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 Energy-converting hydrogenase B subunit P (EhbP) FAD_binding_2 PF00890.24 EEA25215.1 - 0.054 12.6 1.5 0.13 11.3 1.5 1.6 1 0 0 1 1 1 0 FAD binding domain SMC_Nse1 PF07574.13 EEA25215.1 - 0.13 12.1 1.2 0.25 11.2 1.2 1.4 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex Pyr_redox PF00070.27 EEA25215.1 - 0.14 12.7 0.8 0.35 11.5 0.8 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase APH PF01636.23 EEA25215.1 - 0.2 11.5 0.9 0.64 9.9 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family 3HCDH_N PF02737.18 EEA25215.1 - 0.76 9.6 2.7 0.36 10.7 0.1 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EEA25216.1 - 3.1e-44 150.5 0.0 5.8e-44 149.6 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA25216.1 - 1.7e-05 24.5 0.0 3.3e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA25216.1 - 0.012 15.8 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short PF00106.25 EEA25218.1 - 1.5e-33 115.9 0.0 2.6e-33 115.1 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25218.1 - 1.5e-26 93.5 0.0 2.3e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.8 EEA25218.1 - 0.018 14.8 0.9 0.18 11.6 0.2 2.3 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADH_zinc_N PF00107.26 EEA25218.1 - 0.046 13.7 0.1 0.15 12.0 0.1 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA25218.1 - 0.049 13.0 0.0 0.42 9.9 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 EEA25218.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Cul7 PF11515.8 EEA25218.1 - 0.16 12.2 0.0 0.51 10.7 0.0 1.7 2 0 0 2 2 2 0 Mouse development and cellular proliferation protein Cullin-7 Amidohydro_1 PF01979.20 EEA25219.1 - 3.1e-56 191.1 0.1 3.7e-56 190.9 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA25219.1 - 1e-10 41.7 0.0 1.1e-07 31.7 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 EEA25219.1 - 0.00066 19.1 0.0 0.0014 18.1 0.0 1.5 1 0 0 1 1 1 1 Adenosine/AMP deaminase adh_short PF00106.25 EEA25220.1 - 3e-17 62.7 0.2 7.9e-17 61.4 0.2 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA25220.1 - 1.2e-09 38.3 0.1 2.3e-09 37.4 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EEA25220.1 - 7.6e-09 35.5 0.0 1.3e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PEX11 PF05648.14 EEA25221.1 - 2.5e-34 118.7 0.0 2.8e-34 118.5 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) F-actin_cap_A PF01267.17 EEA25222.1 - 2.5e-95 318.9 0.0 2.8e-95 318.7 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF3188 PF11384.8 EEA25225.1 - 0.00019 21.1 0.3 0.00029 20.5 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3188) PIRT PF15099.6 EEA25225.1 - 0.0072 15.9 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family DAG1 PF05454.11 EEA25225.1 - 0.0081 15.6 0.4 0.015 14.7 0.0 1.6 2 0 0 2 2 2 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Orf78 PF06024.12 EEA25225.1 - 0.016 15.5 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF3185 PF11381.8 EEA25225.1 - 0.017 15.1 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) EphA2_TM PF14575.6 EEA25225.1 - 0.019 15.8 0.0 0.04 14.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EEA25225.1 - 0.024 14.6 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family TMEM171 PF15471.6 EEA25225.1 - 0.064 12.2 0.1 0.064 12.2 0.1 1.7 1 1 0 1 1 1 0 Transmembrane protein family 171 TMEM72 PF16054.5 EEA25225.1 - 0.14 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein family 72 SNF2_N PF00176.23 EEA25226.1 - 1.9e-62 211.0 0.0 3.4e-62 210.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA25226.1 - 2.6e-18 66.4 0.0 3.7e-17 62.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 EEA25226.1 - 4.3e-09 36.1 3.0 8.5e-09 35.1 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA25226.1 - 3.8e-08 33.0 2.2 3.8e-08 33.0 2.2 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EEA25226.1 - 3.2e-06 27.2 0.5 9.6e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-RING_2 PF13639.6 EEA25226.1 - 7.2e-06 26.2 3.2 1.5e-05 25.2 3.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EEA25226.1 - 5.6e-05 22.9 2.9 0.00011 21.9 2.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA25226.1 - 0.00011 22.1 3.4 0.00022 21.1 3.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA25226.1 - 0.00016 21.6 1.4 0.00034 20.6 1.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 EEA25226.1 - 0.0013 18.5 4.2 0.0029 17.4 4.2 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EEA25226.1 - 0.0018 18.1 3.7 0.0071 16.2 3.7 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EEA25226.1 - 0.034 14.3 4.7 0.077 13.2 4.7 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_14 PF17978.1 EEA25226.1 - 0.05 14.0 0.4 0.11 12.9 0.4 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EEA25226.1 - 0.095 12.5 0.4 0.22 11.3 0.4 1.6 1 0 0 1 1 1 0 RING-like zinc finger CDC45 PF02724.14 EEA25226.1 - 0.4 8.9 19.3 0.82 7.9 19.3 1.4 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EEA25226.1 - 0.47 9.8 22.4 0.95 8.8 22.4 1.4 1 0 0 1 1 1 0 SDA1 DZR PF12773.7 EEA25226.1 - 1.3 9.1 4.5 4.1 7.5 4.7 1.7 1 1 0 1 1 1 0 Double zinc ribbon YL1 PF05764.13 EEA25226.1 - 3.5 7.7 31.0 0.39 10.8 23.1 2.4 2 0 0 2 2 2 0 YL1 nuclear protein Ras PF00071.22 EEA25227.1 - 6.1e-49 165.7 0.0 7.4e-49 165.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA25227.1 - 3.9e-29 101.3 0.0 1e-28 100.0 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA25227.1 - 8.1e-10 38.4 0.0 1.1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 EEA25227.1 - 0.00055 20.3 0.1 0.0033 17.8 0.1 2.1 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 EEA25227.1 - 0.00067 19.7 0.0 0.0012 18.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EEA25227.1 - 0.0042 16.5 0.0 0.0054 16.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EEA25227.1 - 0.021 14.7 0.1 6.4 6.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Pox_A32 PF04665.12 EEA25227.1 - 0.023 14.2 0.1 0.043 13.3 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_7 PF12775.7 EEA25227.1 - 0.038 13.5 0.1 0.062 12.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 EEA25227.1 - 0.038 13.2 1.8 1.7 7.7 0.1 2.4 2 1 1 3 3 3 0 G-protein alpha subunit AAA_24 PF13479.6 EEA25227.1 - 0.07 12.9 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EEA25227.1 - 0.086 12.8 0.1 0.18 11.8 0.1 1.5 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EEA25227.1 - 0.1 12.7 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA25227.1 - 0.13 12.6 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Nas2_N PF18265.1 EEA25228.1 - 5.2e-29 100.0 0.1 7.3e-29 99.5 0.1 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 EEA25228.1 - 1e-12 47.7 0.2 1.7e-12 46.9 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EEA25228.1 - 3.3e-07 30.5 0.0 8.8e-07 29.2 0.1 1.7 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EEA25228.1 - 2.5e-06 27.7 0.1 4.7e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 EEA25228.1 - 6.4e-06 26.5 0.0 1e-05 25.9 0.0 1.4 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain Nop PF01798.18 EEA25228.1 - 0.12 11.9 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin Nas2_N PF18265.1 EEA25229.1 - 4.8e-19 68.1 0.1 6.9e-19 67.6 0.1 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 EEA25229.1 - 6.1e-13 48.4 0.2 1e-12 47.7 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EEA25229.1 - 2.8e-07 30.8 0.0 4.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EEA25229.1 - 1.7e-06 28.3 0.1 2.7e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 EEA25229.1 - 3.2e-06 27.5 0.0 4.6e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain RhoGEF PF00621.20 EEA25230.1 - 2.6e-18 66.9 0.4 4.3e-18 66.2 0.4 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 EEA25230.1 - 0.051 14.1 0.0 0.18 12.3 0.0 2.0 2 0 0 2 2 2 0 PH domain SBDS PF01172.18 EEA25231.1 - 7.5e-26 90.0 0.0 9.1e-26 89.8 0.0 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS PF01172.18 EEA25232.1 - 7.5e-26 90.0 0.0 9.1e-26 89.8 0.0 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein UDG PF03167.19 EEA25233.1 - 9.4e-18 64.7 0.0 2.1e-17 63.6 0.0 1.5 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily DDE_1 PF03184.19 EEA25234.1 - 5.1e-24 84.9 0.0 1e-23 83.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA25234.1 - 8.7e-09 35.3 0.3 3.4e-08 33.4 0.3 2.1 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA25234.1 - 0.0096 16.0 0.1 0.18 12.0 0.0 2.6 3 0 0 3 3 3 1 Transcription factor Pcc1 Amidase PF01425.21 EEA25234.1 - 0.082 11.8 1.5 0.13 11.2 1.5 1.2 1 0 0 1 1 1 0 Amidase MFS_1 PF07690.16 EEA25236.1 - 5.9e-33 114.2 35.5 5.9e-33 114.2 35.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA25236.1 - 8.3e-14 51.3 11.4 8.3e-14 51.3 11.4 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EEA25236.1 - 8.4e-07 27.8 6.4 1.2e-06 27.2 6.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Aldo_ket_red PF00248.21 EEA25237.1 - 9.9e-65 218.6 0.1 1.2e-64 218.4 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family LpxI_C PF06230.11 EEA25237.1 - 0.036 13.9 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 LpxI C-terminal domain NAD_binding_8 PF13450.6 EEA25238.1 - 5.9e-10 39.2 0.3 1.3e-09 38.1 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EEA25238.1 - 3.6e-08 33.2 0.5 5.8e-08 32.5 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA25238.1 - 8.2e-08 31.7 0.7 1.2e-07 31.2 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EEA25238.1 - 8.9e-07 27.9 0.4 1.3e-06 27.4 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein Amino_oxidase PF01593.24 EEA25238.1 - 9.3e-05 21.9 0.0 0.00035 20.0 0.0 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EEA25238.1 - 0.00025 21.6 0.1 0.00059 20.3 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA25238.1 - 0.0013 18.0 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA25238.1 - 0.0013 18.4 0.3 0.0021 17.7 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EEA25238.1 - 0.0044 16.2 0.4 0.0071 15.5 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EEA25238.1 - 0.009 15.3 0.2 0.02 14.2 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA25238.1 - 0.031 13.5 0.2 0.052 12.8 0.2 1.2 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EEA25238.1 - 0.045 13.1 0.1 0.078 12.3 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EEA25238.1 - 0.11 11.7 0.6 0.18 11.0 0.6 1.2 1 0 0 1 1 1 0 FAD binding domain Zn_clus PF00172.18 EEA25239.1 - 1.6e-08 34.5 10.9 3.5e-08 33.4 10.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EEA25240.1 - 8.2e-72 242.4 0.0 1.1e-71 242.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ndr PF03096.14 EEA25240.1 - 0.016 13.9 0.2 0.6 8.7 0.0 2.2 2 0 0 2 2 2 0 Ndr family Duffy_binding PF05424.11 EEA25240.1 - 0.035 14.2 0.3 0.075 13.1 0.0 1.7 2 1 1 3 3 3 0 Duffy binding domain FancD2 PF14631.6 EEA25240.1 - 0.081 10.3 0.0 3.8 4.8 0.0 2.0 2 0 0 2 2 2 0 Fanconi anaemia protein FancD2 nuclease FAD_binding_3 PF01494.19 EEA25241.1 - 7.3e-22 78.1 0.1 3.1e-20 72.7 0.1 2.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA25241.1 - 5.6e-05 23.3 0.0 0.00015 21.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA25241.1 - 0.0029 18.1 0.0 0.0072 16.9 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA25241.1 - 0.019 14.6 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA25241.1 - 0.021 14.0 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA25241.1 - 0.022 14.0 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EEA25241.1 - 0.049 12.7 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EEA25241.1 - 0.067 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EEA25241.1 - 0.1 11.9 0.0 1.3 8.3 0.0 2.1 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain EthD PF07110.11 EEA25242.1 - 6.1e-17 62.6 0.7 9.2e-17 62.0 0.7 1.3 1 0 0 1 1 1 1 EthD domain NAD_binding_10 PF13460.6 EEA25243.1 - 2.1e-13 50.6 0.0 4e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA25243.1 - 6e-12 45.6 0.0 9.3e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Shikimate_DH PF01488.20 EEA25243.1 - 0.00011 22.3 0.2 0.0002 21.4 0.2 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EEA25243.1 - 0.0008 18.9 0.1 0.0013 18.2 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EEA25243.1 - 0.0048 17.3 0.2 0.012 16.1 0.2 1.7 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 EEA25243.1 - 0.0077 16.0 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ApbA PF02558.16 EEA25243.1 - 0.008 15.8 0.2 0.017 14.8 0.1 1.6 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EEA25243.1 - 0.011 16.2 0.1 0.026 15.1 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 EEA25243.1 - 0.014 15.5 0.1 0.026 14.7 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_2 PF03446.15 EEA25243.1 - 0.016 15.4 0.0 0.13 12.4 0.0 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase GDP_Man_Dehyd PF16363.5 EEA25243.1 - 0.024 14.0 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase KR PF08659.10 EEA25243.1 - 0.03 14.2 0.1 0.073 13.0 0.1 1.7 2 0 0 2 2 2 0 KR domain GFO_IDH_MocA PF01408.22 EEA25243.1 - 0.033 15.0 0.0 0.063 14.1 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold 3Beta_HSD PF01073.19 EEA25243.1 - 0.072 12.1 0.0 0.82 8.6 0.0 2.0 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EEA25243.1 - 0.13 12.5 0.1 0.25 11.6 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain DLH PF01738.18 EEA25244.1 - 1.4e-08 34.6 0.0 1.7e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family ketoacyl-synt PF00109.26 EEA25245.1 - 4.6e-76 255.7 0.0 7.6e-76 255.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EEA25245.1 - 1e-65 221.8 1.4 2.7e-65 220.4 0.2 2.3 2 1 1 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EEA25245.1 - 4.9e-39 134.7 0.0 7.9e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA25245.1 - 1.3e-34 118.7 0.0 2.8e-34 117.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EEA25245.1 - 2.2e-28 98.4 2.5 1.6e-13 50.7 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thioesterase PF00975.20 EEA25245.1 - 5.1e-21 75.9 0.0 1.5e-20 74.4 0.0 1.8 1 0 0 1 1 1 1 Thioesterase domain PS-DH PF14765.6 EEA25245.1 - 1.1e-14 54.4 0.0 1.7e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EEA25245.1 - 2.5e-05 24.7 0.0 7e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 EEA25245.1 - 0.00018 22.2 0.0 0.00059 20.5 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thiolase_N PF00108.23 EEA25245.1 - 0.0061 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain DUF2974 PF11187.8 EEA25245.1 - 0.034 13.7 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) ACP_syn_III PF08545.10 EEA25245.1 - 0.13 12.2 0.2 0.77 9.7 0.1 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Fe-ADH PF00465.19 EEA25246.1 - 2.9e-53 181.0 0.0 3.6e-53 180.7 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EEA25246.1 - 1.2e-07 31.7 0.0 1.7e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DUF807 PF05660.11 EEA25246.1 - 0.14 12.1 0.0 0.39 10.7 0.0 1.7 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) Methyltransf_2 PF00891.18 EEA25247.1 - 9.4e-11 41.4 0.0 1.7e-10 40.6 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase domain p450 PF00067.22 EEA25248.1 - 6.7e-49 166.9 0.0 9.2e-49 166.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cupin_2 PF07883.11 EEA25249.1 - 1.1e-12 47.5 0.2 1.9e-12 46.7 0.2 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EEA25249.1 - 0.021 14.4 0.1 0.042 13.5 0.1 1.4 1 0 0 1 1 1 0 Cupin EthD PF07110.11 EEA25251.1 - 0.0042 18.2 0.0 0.0073 17.4 0.0 1.5 1 0 0 1 1 1 1 EthD domain NAD_binding_6 PF08030.12 EEA25253.1 - 1.6e-22 80.3 0.0 2.5e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EEA25253.1 - 1.1e-21 76.9 0.0 2.2e-21 76.0 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EEA25253.1 - 3.3e-19 69.2 8.1 3.3e-19 69.2 8.1 2.2 1 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 EEA25253.1 - 0.16 12.6 0.0 4.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain NRDE-2 PF08424.10 EEA25254.1 - 1.6e-98 329.8 2.1 1e-97 327.2 2.6 2.1 2 0 0 2 2 2 1 NRDE-2, necessary for RNA interference BP28CT PF08146.12 EEA25255.1 - 3.4e-41 140.7 3.6 7.8e-41 139.5 1.9 2.7 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EEA25255.1 - 6.5e-24 84.5 1.1 6.5e-24 84.5 1.1 5.9 5 1 1 6 6 6 1 U3 small nucleolar RNA-associated protein 10 HEAT_EZ PF13513.6 EEA25255.1 - 0.0003 21.2 14.9 0.21 12.1 0.2 7.1 8 1 1 9 9 9 2 HEAT-like repeat Tti2 PF10521.9 EEA25255.1 - 0.00033 20.3 0.3 0.069 12.7 0.0 3.6 2 1 1 3 3 3 1 Tti2 family HEAT PF02985.22 EEA25255.1 - 0.2 12.0 7.8 4.8 7.7 0.0 6.1 6 0 0 6 6 6 0 HEAT repeat Ank_2 PF12796.7 EEA25256.1 - 1.3e-44 150.7 0.0 6.8e-10 39.4 0.0 5.7 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA25256.1 - 5.1e-43 144.6 0.2 2.2e-12 46.9 0.0 6.7 4 2 3 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA25256.1 - 4.1e-34 112.7 0.4 0.0075 16.7 0.0 10.3 10 0 0 10 10 9 9 Ankyrin repeat Ank_4 PF13637.6 EEA25256.1 - 2.5e-32 110.8 0.5 3.3e-07 30.7 0.0 7.7 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EEA25256.1 - 2e-25 88.1 0.0 0.014 15.8 0.0 10.0 10 0 0 10 10 10 6 Ankyrin repeat NACHT PF05729.12 EEA25256.1 - 2.1e-08 34.3 0.0 4.5e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 EEA25256.1 - 0.0077 15.5 0.1 4.2 6.5 0.0 2.7 2 1 1 3 3 3 2 KAP family P-loop domain AAA_22 PF13401.6 EEA25256.1 - 0.037 14.3 0.1 0.15 12.3 0.1 2.1 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA25256.1 - 0.079 12.9 0.1 0.23 11.4 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EEA25256.1 - 0.08 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 EEA25256.1 - 0.096 12.7 0.0 5.7 6.9 0.0 3.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Bul1_N PF04425.12 EEA25257.1 - 0.00012 20.9 1.0 0.00025 20.0 0.4 1.7 2 0 0 2 2 2 1 Bul1 N terminus Arrestin_N PF00339.29 EEA25257.1 - 0.00056 20.0 0.0 0.0019 18.3 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 EEA25257.1 - 0.002 17.6 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 Bul1 C terminus Sulfatase PF00884.23 EEA25258.1 - 6.7e-61 206.4 0.1 8.6e-61 206.0 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 EEA25258.1 - 1.5e-20 72.7 0.7 2.8e-20 71.9 0.7 1.5 1 0 0 1 1 1 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 EEA25258.1 - 1e-11 45.1 0.4 6.9e-10 39.0 0.1 2.5 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 EEA25258.1 - 0.013 16.2 0.3 0.036 14.8 0.2 1.7 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF229 PF02995.17 EEA25258.1 - 0.013 14.1 0.0 0.017 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF1501 PF07394.12 EEA25258.1 - 0.013 14.5 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF4976 PF16347.5 EEA25258.1 - 0.071 13.4 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) EMP70 PF02990.16 EEA25259.1 - 9.2e-198 658.1 0.3 1.2e-197 657.7 0.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 ubiquitin PF00240.23 EEA25260.1 - 1.8e-21 75.7 0.0 2.6e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EEA25260.1 - 2.6e-09 36.8 0.0 4.2e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EEA25260.1 - 3.6e-08 33.1 0.1 1e-07 31.7 0.1 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 EEA25260.1 - 1.2e-06 28.6 0.0 2.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EEA25260.1 - 5.3e-06 26.9 0.0 1.2e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain YukD PF08817.10 EEA25260.1 - 0.0024 18.5 0.0 0.0091 16.7 0.0 2.0 2 0 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.6 EEA25260.1 - 0.0048 17.3 0.1 0.018 15.5 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Blt1 PF12754.7 EEA25260.1 - 0.074 13.4 0.9 0.098 13.0 0.1 1.7 2 0 0 2 2 2 0 Blt1 N-terminal domain STI1 PF17830.1 EEA25260.1 - 0.15 12.0 19.5 1.7 8.7 1.7 3.7 2 1 1 3 3 3 0 STI1 domain GerD PF17898.1 EEA25260.1 - 3.4 7.6 4.9 4.6 7.2 2.9 2.1 2 1 1 3 3 3 0 Spore germination GerD central core domain MMS1_N PF10433.9 EEA25261.1 - 7.5e-160 532.8 0.0 1.7e-159 531.6 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EEA25261.1 - 2.6e-100 335.9 0.0 1.9e-99 333.1 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 EEA25261.1 - 0.0073 16.6 0.0 0.36 11.2 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_N PF14781.6 EEA25261.1 - 0.071 13.0 0.1 40 4.2 0.0 3.7 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, N-terminal CN_hydrolase PF00795.22 EEA25262.1 - 3.4e-30 105.2 0.0 6.7e-26 91.2 0.0 2.2 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase GrpB PF04229.14 EEA25263.1 - 2.7e-47 161.0 0.0 3.1e-47 160.7 0.0 1.0 1 0 0 1 1 1 1 GrpB protein GrpB PF04229.14 EEA25264.1 - 2.7e-47 161.0 0.0 3.1e-47 160.7 0.0 1.0 1 0 0 1 1 1 1 GrpB protein Asparaginase_2 PF01112.18 EEA25265.1 - 5.6e-72 242.4 6.2 8.4e-72 241.8 6.2 1.2 1 0 0 1 1 1 1 Asparaginase tRNA-synt_2 PF00152.20 EEA25265.1 - 2.9e-26 92.3 0.0 4.5e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) HIT PF01230.23 EEA25265.1 - 2e-10 41.3 0.0 0.00051 20.7 0.0 2.6 2 0 0 2 2 2 2 HIT domain tRNA-synt_2d PF01409.20 EEA25265.1 - 0.00017 21.2 0.1 0.28 10.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) MFS_1 PF07690.16 EEA25267.1 - 5.9e-34 117.5 56.1 9.5e-34 116.9 56.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Annexin PF00191.20 EEA25267.1 - 0.061 13.4 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Annexin ArAE_2_N PF10337.9 EEA25268.1 - 5.7e-35 121.2 11.4 1.2e-31 110.3 8.6 3.7 2 1 0 2 2 2 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EEA25268.1 - 2.3e-12 47.1 16.6 2.3e-12 47.1 16.6 2.5 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EEA25268.1 - 0.00012 22.0 0.2 0.0012 18.7 0.2 2.8 1 1 0 1 1 1 1 Aromatic acid exporter family member 2 BING4CT PF08149.11 EEA25268.1 - 0.019 14.7 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 BING4CT (NUC141) domain BAR_3 PF16746.5 EEA25268.1 - 0.079 12.7 0.1 0.2 11.3 0.0 1.7 2 0 0 2 2 2 0 BAR domain of APPL family RGS12_us2 PF16611.5 EEA25269.1 - 0.021 15.2 4.4 0.082 13.3 4.4 2.1 1 0 0 1 1 1 0 Unstructured region between RBD and GoLoco Pyridoxal_deC PF00282.19 EEA25270.1 - 2.1e-76 257.1 0.0 2.8e-76 256.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EEA25270.1 - 0.00013 21.0 0.0 0.00023 20.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 EEA25270.1 - 0.014 14.2 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain TPR_1 PF00515.28 EEA25271.1 - 2.6e-07 30.1 3.5 0.018 14.9 0.8 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA25271.1 - 5.3e-07 29.3 3.4 0.14 12.3 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA25271.1 - 0.0049 17.3 0.3 0.033 14.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA25271.1 - 0.046 13.9 3.2 9.2 6.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Pox_T4_N PF04491.12 EEA25271.1 - 0.082 12.8 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus TPR_16 PF13432.6 EEA25271.1 - 0.12 13.0 0.0 2 9.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat CheR PF01739.18 EEA25271.1 - 0.17 11.3 2.5 2.5 7.5 0.1 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Fis1_TPR_C PF14853.6 EEA25271.1 - 0.29 11.2 2.0 28 4.9 0.6 2.9 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat UPF0160 PF03690.13 EEA25272.1 - 0.039 13.6 0.0 0.048 13.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) Nyv1_N PF09426.10 EEA25272.1 - 0.098 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal eIF-3_zeta PF05091.12 EEA25273.1 - 0.049 12.6 17.9 0.065 12.2 17.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 EEA25273.1 - 0.098 12.1 13.5 0.14 11.6 13.5 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Plasmodium_Vir PF05795.11 EEA25273.1 - 0.24 10.8 7.7 0.32 10.4 7.7 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DcuA_DcuB PF03605.14 EEA25273.1 - 0.25 10.2 8.6 0.41 9.5 8.6 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF648 PF04890.13 EEA25273.1 - 0.29 10.8 11.2 0.36 10.5 11.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF648) PPL5 PF18168.1 EEA25273.1 - 0.33 10.2 7.7 0.5 9.6 7.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Band_3_cyto PF07565.13 EEA25273.1 - 0.34 10.7 12.1 0.49 10.2 12.1 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Peptidase_S49_N PF08496.10 EEA25273.1 - 0.36 10.9 13.7 0.65 10.1 13.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 EEA25273.1 - 0.73 9.6 19.7 1.2 8.9 19.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Draxin PF15550.6 EEA25273.1 - 0.92 9.3 14.2 1.3 8.8 14.2 1.4 1 0 0 1 1 1 0 Draxin GREB1 PF15782.5 EEA25273.1 - 0.94 6.5 24.6 1.1 6.3 24.6 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2052 PF09747.9 EEA25273.1 - 1.2 9.3 19.3 2 8.5 19.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Macoilin PF09726.9 EEA25273.1 - 2.3 6.6 15.8 3 6.3 15.8 1.1 1 0 0 1 1 1 0 Macoilin family Peptidase_S15 PF02129.18 EEA25273.1 - 2.4 7.7 17.9 4.5 6.8 17.9 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) YABBY PF04690.13 EEA25273.1 - 2.9 8.4 17.2 6 7.4 17.2 1.6 1 0 0 1 1 1 0 YABBY protein SID-1_RNA_chan PF13965.6 EEA25273.1 - 3.4 6.0 6.1 4.4 5.6 6.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 EEA25273.1 - 4.3 6.2 20.0 6 5.8 20.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 EOS1 PF12326.8 EEA25273.1 - 5.4 6.9 6.8 8.9 6.2 6.8 1.5 1 0 0 1 1 1 0 N-glycosylation protein CDK5_activator PF03261.15 EEA25273.1 - 5.5 6.4 16.3 7.6 6.0 16.3 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Membralin PF09746.9 EEA25273.1 - 6 5.8 11.7 8.2 5.4 11.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein Zip PF02535.22 EEA25273.1 - 6.3 5.9 6.0 8.5 5.5 6.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter V_ATPase_I PF01496.19 EEA25273.1 - 6.8 4.5 19.1 9.2 4.0 19.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4638 PF15472.6 EEA25273.1 - 7.4 6.2 15.5 11 5.6 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Rtf2 PF04641.12 EEA25273.1 - 7.7 5.8 18.4 13 5.1 18.4 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Exonuc_VII_L PF02601.15 EEA25273.1 - 8 5.9 22.3 12 5.4 22.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM176 PF14851.6 EEA25273.1 - 8 6.1 9.2 14 5.3 9.2 1.3 1 0 0 1 1 1 0 FAM176 family TERB2 PF15101.6 EEA25273.1 - 9.3 6.2 26.7 18 5.3 26.7 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF1682 PF07946.14 EEA25273.1 - 9.9 5.3 15.0 10 5.2 13.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) PDZ_1 PF12812.7 EEA25274.1 - 3e-54 181.0 0.1 1e-35 121.6 0.0 3.0 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 EEA25274.1 - 5e-24 85.9 0.6 3.7e-21 76.6 0.1 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 EEA25274.1 - 4.9e-19 67.9 0.1 3.4e-09 36.4 0.4 4.5 4 0 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 EEA25274.1 - 9.1e-13 48.3 0.0 0.00011 22.5 0.0 3.9 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.24 EEA25274.1 - 3.1e-12 46.7 0.0 0.00011 22.5 0.0 3.7 3 0 0 3 3 3 3 PDZ domain Trypsin PF00089.26 EEA25274.1 - 0.00068 19.5 0.1 0.0029 17.5 0.1 2.0 1 1 0 1 1 1 1 Trypsin 4HPAD_g_N PF18671.1 EEA25274.1 - 0.0048 16.6 0.0 0.015 15.0 0.0 1.9 1 0 0 1 1 1 1 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal Tricorn_PDZ PF14685.6 EEA25274.1 - 0.0076 16.2 0.1 1.8 8.6 0.1 3.7 4 0 0 4 4 4 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 EEA25274.1 - 0.023 13.4 0.1 0.048 12.3 0.1 1.4 1 0 0 1 1 1 0 Peptidase S46 Peptidase_S7 PF00949.21 EEA25274.1 - 0.11 12.4 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Pup PF05639.11 EEA25274.1 - 0.11 13.4 0.0 1.3 10.0 0.0 2.4 2 0 0 2 2 2 0 Pup-like protein MFS_1 PF07690.16 EEA25275.1 - 1.3e-14 54.0 19.9 1.6e-14 53.6 19.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily HMG_box PF00505.19 EEA25275.1 - 0.15 12.5 0.0 19 5.7 0.0 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box DUF5012 PF16404.5 EEA25276.1 - 0.041 14.0 0.0 0.059 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5012) FBPase_2 PF06874.11 EEA25276.1 - 0.28 9.4 0.0 0.37 9.0 0.0 1.0 1 0 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase Chorein_N PF12624.7 EEA25277.1 - 0.13 12.4 1.0 0.42 10.7 1.0 1.8 1 1 0 1 1 1 0 N-terminal region of Chorein or VPS13 GFA PF04828.14 EEA25278.1 - 2.4e-05 24.6 2.7 2.4e-05 24.6 2.7 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Thymidylat_synt PF00303.19 EEA25279.1 - 5e-108 360.3 0.0 5.7e-108 360.1 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Peptidase_A4 PF01828.17 EEA25280.1 - 1.5e-76 256.5 11.4 1.8e-76 256.3 11.4 1.1 1 0 0 1 1 1 1 Peptidase A4 family GST_N PF02798.20 EEA25281.1 - 3.9e-16 59.1 0.0 5.8e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA25281.1 - 1.9e-13 50.6 0.0 3e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA25281.1 - 9.3e-11 41.9 0.0 1.5e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA25281.1 - 1.9e-09 37.6 0.0 3.8e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA25281.1 - 1.7e-08 34.4 0.0 4.4e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA25281.1 - 0.0009 19.4 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Zn_clus PF00172.18 EEA25282.1 - 4.8e-07 29.8 9.3 4.8e-07 29.8 9.3 2.5 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_12 PF13424.6 EEA25283.1 - 2e-27 95.3 6.6 1e-09 38.5 0.0 5.2 4 1 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 EEA25283.1 - 4.3e-22 77.3 12.2 2.7e-06 27.1 0.0 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EEA25283.1 - 7.3e-09 35.1 8.2 0.61 10.2 0.0 7.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA25283.1 - 2.3e-07 30.5 7.1 0.00078 18.9 0.1 3.6 3 1 0 3 3 3 2 MalT-like TPR region TPR_19 PF14559.6 EEA25283.1 - 1.2e-06 29.0 7.9 3 8.4 0.1 5.4 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA25283.1 - 2.1e-06 28.2 6.1 0.088 13.5 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EEA25283.1 - 1.8e-05 25.2 10.5 2.6 9.1 0.2 6.3 6 1 1 7 7 7 3 Tetratricopeptide repeat PPR PF01535.20 EEA25283.1 - 0.00027 21.0 0.0 1.2 9.5 0.0 4.2 4 0 0 4 4 4 1 PPR repeat TPR_11 PF13414.6 EEA25283.1 - 0.011 15.3 0.4 1.5 8.6 0.0 3.9 5 0 0 5 5 5 0 TPR repeat TPR_2 PF07719.17 EEA25283.1 - 0.015 15.4 1.7 18 5.8 0.0 5.4 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_4 PF07721.14 EEA25283.1 - 0.024 15.3 8.1 6.5 7.7 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA25283.1 - 0.081 13.2 0.1 15 6.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA25283.1 - 0.17 12.6 3.6 1.8e+02 3.1 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat INCENP_ARK-bind PF03941.15 EEA25284.1 - 4.6e-16 58.5 2.8 4.6e-16 58.5 2.8 2.7 3 0 0 3 3 3 1 Inner centromere protein, ARK binding region Reticulon PF02453.17 EEA25285.1 - 2.7e-28 98.9 2.0 3.7e-28 98.5 2.0 1.2 1 0 0 1 1 1 1 Reticulon YL1 PF05764.13 EEA25286.1 - 4e-06 27.1 11.0 7.3e-06 26.3 11.0 1.3 1 0 0 1 1 1 1 YL1 nuclear protein DNA_topoisoIV PF00521.20 EEA25287.1 - 2.2e-137 458.5 0.9 4.3e-137 457.5 0.2 1.8 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EEA25287.1 - 5e-53 178.8 6.9 1.7e-52 177.1 6.9 2.0 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EEA25287.1 - 1.9e-26 92.6 2.6 5.6e-26 91.1 2.6 1.8 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EEA25287.1 - 4.6e-16 59.3 0.1 1.7e-15 57.5 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EEA25287.1 - 1.2e-06 28.6 0.0 6.3e-06 26.4 0.0 2.3 1 0 0 1 1 1 1 Toprim domain RabGAP-TBC PF00566.18 EEA25288.1 - 9.3e-49 166.0 0.3 3e-48 164.3 0.0 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Euplotes_phero PF05842.11 EEA25288.1 - 0.13 12.8 0.1 0.93 10.1 0.0 2.3 1 1 0 2 2 2 0 Euplotes octocarinatus mating pheromone protein MSC PF09402.10 EEA25288.1 - 6 6.2 14.1 6.8 6.0 4.7 2.4 1 1 1 2 2 2 0 Man1-Src1p-C-terminal domain T2SSF PF00482.23 EEA25288.1 - 8.3 6.4 8.3 5.7 6.9 0.1 3.2 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F Fungal_trans PF04082.18 EEA25290.1 - 0.00015 20.9 0.1 0.00025 20.2 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyr_redox_2 PF07992.14 EEA25291.1 - 8.9e-18 64.5 0.0 1.4e-16 60.6 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA25291.1 - 0.0021 18.6 0.1 0.037 14.6 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SBDS_C PF09377.10 EEA25292.1 - 2.6e-44 149.9 0.0 4.8e-44 149.1 0.0 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EEA25292.1 - 3.8e-30 103.8 0.7 7.1e-30 102.9 0.7 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein AP3D1 PF06375.11 EEA25292.1 - 0.0085 16.3 1.4 0.022 15.0 1.4 1.7 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 S-antigen PF05756.11 EEA25292.1 - 0.53 10.7 2.8 1.2 9.5 2.8 1.5 1 0 0 1 1 1 0 S-antigen protein Peptidase_S10 PF00450.22 EEA25293.1 - 3.5e-131 438.5 0.2 4.3e-131 438.2 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EEA25293.1 - 3.8e-15 56.5 0.0 9.6e-15 55.2 0.0 1.7 2 0 0 2 2 2 1 Carboxypeptidase Y pro-peptide ApoLp-III PF07464.11 EEA25293.1 - 0.0012 19.0 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Ribosomal_S13 PF00416.22 EEA25294.1 - 2.7e-56 189.5 3.7 3.1e-56 189.3 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EEA25294.1 - 0.056 12.2 0.0 0.057 12.2 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF2746 PF10874.8 EEA25294.1 - 0.06 13.8 0.0 0.1 13.0 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2746) HHH_6 PF14579.6 EEA25294.1 - 0.1 12.8 0.0 0.33 11.2 0.0 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_S13 PF00416.22 EEA25295.1 - 4.1e-51 172.7 2.0 4.6e-51 172.5 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 DUF2746 PF10874.8 EEA25295.1 - 0.039 14.4 0.0 0.067 13.6 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2746) DUF1822 PF08852.11 EEA25295.1 - 0.11 11.5 0.0 0.13 11.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) FbpA PF05833.11 EEA25295.1 - 0.12 11.1 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Med4 PF10018.9 EEA25296.1 - 1.6e-44 151.9 4.1 2.2e-44 151.4 4.1 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 RP-C_C PF11800.8 EEA25296.1 - 0.00033 20.8 1.3 0.00033 20.8 1.3 1.9 2 0 0 2 2 2 1 Replication protein C C-terminal region PBP1_TM PF14812.6 EEA25296.1 - 0.014 15.8 6.8 0.04 14.3 6.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pes-10 PF07149.11 EEA25296.1 - 0.032 13.3 3.2 0.044 12.8 3.2 1.2 1 0 0 1 1 1 0 Pes-10 DUF572 PF04502.13 EEA25296.1 - 0.51 9.9 8.7 0.76 9.3 8.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) YL1 PF05764.13 EEA25296.1 - 0.54 10.3 12.7 0.9 9.6 12.7 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Baculo_PEP_C PF04513.12 EEA25296.1 - 0.95 9.5 5.6 13 5.8 1.1 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_DNA_bd PF12329.8 EEA25296.1 - 1.1 9.3 7.7 1.7 8.7 0.2 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF2151 PF10221.9 EEA25296.1 - 2 6.9 8.1 2.2 6.8 2.0 1.9 1 1 1 2 2 2 0 Cell cycle and development regulator CDC45 PF02724.14 EEA25296.1 - 4.1 5.6 10.2 5 5.3 10.2 1.2 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 EEA25296.1 - 4.5 5.7 7.3 5.5 5.4 7.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 MFS_1 PF07690.16 EEA25297.1 - 5e-22 78.3 21.2 5e-22 78.3 21.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 EEA25298.1 - 1.5e-27 96.5 27.2 1.5e-27 96.5 27.2 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF202 PF02656.15 EEA25299.1 - 8.4e-17 61.4 0.1 3.7e-16 59.3 0.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF202) PatG_D PF18047.1 EEA25299.1 - 0.15 12.5 0.0 0.38 11.2 0.0 1.5 1 1 0 1 1 1 0 PatG Domain Rhodanese PF00581.20 EEA25300.1 - 2e-16 60.4 0.0 4.3e-10 40.1 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain zf-CCCH_4 PF18044.1 EEA25302.1 - 8.8e-05 22.2 1.4 8.8e-05 22.2 1.4 3.6 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EEA25302.1 - 0.00025 20.9 1.5 0.00025 20.9 1.5 3.2 2 1 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) T3SSipB PF16535.5 EEA25302.1 - 0.011 16.2 1.9 0.019 15.4 1.9 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF3450 PF11932.8 EEA25302.1 - 0.051 12.9 3.1 0.081 12.2 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Torus PF16131.5 EEA25302.1 - 0.067 13.9 0.1 0.067 13.9 0.1 2.7 3 1 0 3 3 3 0 Torus domain YkyA PF10368.9 EEA25302.1 - 0.15 11.7 7.1 2 8.1 4.9 2.2 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Dynactin_p22 PF07426.11 EEA25302.1 - 0.16 11.9 2.4 0.29 11.0 2.4 1.4 1 0 0 1 1 1 0 Dynactin subunit p22 WXG100 PF06013.12 EEA25302.1 - 0.58 10.4 2.1 8.3 6.7 0.1 2.4 2 0 0 2 2 2 0 Proteins of 100 residues with WXG zf_CCCH_4 PF18345.1 EEA25302.1 - 0.7 10.0 12.2 0.12 12.4 2.6 3.2 3 0 0 3 3 3 0 Zinc finger domain RVT_1 PF00078.27 EEA25303.1 - 1.4e-19 70.5 0.0 1.2e-14 54.4 0.0 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 EEA25303.1 - 0.0018 18.9 0.2 0.0081 16.9 0.1 2.1 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Hepatitis_core PF00906.20 EEA25303.1 - 0.0072 15.9 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 Hepatitis core antigen Fungal_trans PF04082.18 EEA25304.1 - 8.6e-13 47.9 0.1 1.4e-12 47.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25304.1 - 4.4e-08 33.1 12.4 9.3e-08 32.1 12.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RseC_MucC PF04246.12 EEA25304.1 - 1.7 8.6 4.4 4.2 7.3 4.4 1.7 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC MFS_1 PF07690.16 EEA25305.1 - 1.6e-23 83.3 54.4 2e-16 59.9 32.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA25305.1 - 6.9 5.4 26.9 0.011 14.6 13.2 2.1 1 1 1 2 2 2 0 MFS_1 like family Zn_clus PF00172.18 EEA25306.1 - 4.5e-09 36.3 14.0 7.8e-09 35.5 14.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA25306.1 - 3.3e-08 32.8 0.1 9e-08 31.3 0.1 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF3381 PF11861.8 EEA25306.1 - 0.35 10.7 1.8 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) PHD PF00628.29 EEA25307.1 - 1.6e-05 24.7 8.9 3.3e-05 23.7 8.9 1.5 1 0 0 1 1 1 1 PHD-finger ADK_lid PF05191.14 EEA25307.1 - 0.79 9.8 6.3 0.3 11.1 0.9 2.5 2 0 0 2 2 2 0 Adenylate kinase, active site lid FAD_binding_4 PF01565.23 EEA25308.1 - 7e-22 77.7 4.2 9.6e-22 77.2 2.8 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EEA25308.1 - 8.4e-13 48.2 1.4 2.5e-12 46.7 1.4 1.9 1 0 0 1 1 1 1 Berberine and berberine like LapA_dom PF06305.11 EEA25309.1 - 2.4 8.0 7.6 2.8 7.8 0.0 3.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Glyco_hydro_92 PF07971.12 EEA25310.1 - 1.4e-144 482.5 1.2 1.7e-144 482.2 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EEA25310.1 - 1.3e-61 208.5 3.3 3e-61 207.4 3.3 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain APG17 PF04108.12 EEA25311.1 - 0.041 13.0 0.1 0.051 12.7 0.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 DUF3485 PF11984.8 EEA25313.1 - 0.08 12.7 0.4 0.35 10.6 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3485) Rad4 PF03835.15 EEA25314.1 - 1.5e-37 128.5 0.4 4.5e-37 127.0 0.4 1.8 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EEA25314.1 - 1e-27 96.3 0.2 6.4e-27 93.8 0.1 2.4 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EEA25314.1 - 4.5e-23 80.8 0.3 1e-22 79.7 0.3 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EEA25314.1 - 2.9e-14 53.8 0.1 2.9e-14 53.8 0.1 2.8 2 1 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EEA25314.1 - 0.022 15.2 0.0 0.1 13.1 0.0 2.2 1 1 0 1 1 1 0 Transglutaminase-like superfamily E1_dh PF00676.20 EEA25315.1 - 5.2e-96 321.1 0.0 6.3e-96 320.9 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EEA25315.1 - 0.0041 16.9 1.4 0.0071 16.1 1.4 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EEA25315.1 - 0.095 11.9 0.5 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase Aminotran_3 PF00202.21 EEA25317.1 - 3.5e-94 315.7 0.1 4.6e-94 315.4 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EEA25317.1 - 0.00063 19.0 0.0 0.0018 17.5 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Fungal_trans_2 PF11951.8 EEA25318.1 - 1.4e-14 53.8 0.1 8.1e-09 34.8 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25318.1 - 2.6e-05 24.2 9.4 4.7e-05 23.4 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BSD PF03909.17 EEA25319.1 - 1.3e-20 73.1 1.4 2.8e-20 72.0 1.4 1.6 1 0 0 1 1 1 1 BSD domain Suf PF05843.14 EEA25319.1 - 0.35 10.8 6.5 0.33 10.9 5.2 1.4 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) Ran-binding PF05508.11 EEA25320.1 - 2.1e-116 388.3 0.6 3.4e-116 387.6 0.6 1.3 1 0 0 1 1 1 1 RanGTP-binding protein Rx_N PF18052.1 EEA25320.1 - 0.024 14.9 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 Rx N-terminal domain ALGX PF16822.5 EEA25320.1 - 0.051 13.3 1.1 0.39 10.4 0.1 2.3 2 0 0 2 2 2 0 SGNH hydrolase-like domain, acetyltransferase AlgX GTP_EFTU PF00009.27 EEA25321.1 - 1.7e-40 138.7 0.0 3e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EEA25321.1 - 5e-28 97.6 0.0 1.1e-27 96.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EEA25321.1 - 6.3e-06 26.5 0.1 1.6e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA25321.1 - 0.021 14.9 0.0 0.13 12.3 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase GFA PF04828.14 EEA25322.1 - 1.9e-21 76.2 2.8 2.6e-21 75.8 2.8 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme WGG PF10273.9 EEA25324.1 - 1.1e-28 99.6 0.2 2e-28 98.9 0.2 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 PBP1_TM PF14812.6 EEA25324.1 - 0.027 14.8 13.5 0.08 13.3 13.5 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Vfa1 PF08432.10 EEA25324.1 - 0.036 14.4 4.5 0.051 13.9 4.5 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3245 PF11595.8 EEA25324.1 - 0.099 13.1 7.2 0.19 12.2 7.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) DUF4611 PF15387.6 EEA25324.1 - 0.13 12.5 8.6 0.23 11.7 8.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RXT2_N PF08595.11 EEA25324.1 - 0.18 11.8 6.4 0.27 11.3 6.4 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 EEA25324.1 - 0.39 8.8 15.2 0.54 8.3 15.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF913 PF06025.12 EEA25324.1 - 0.45 9.4 1.4 0.57 9.1 1.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NOA36 PF06524.12 EEA25324.1 - 0.54 9.5 14.8 0.73 9.1 14.8 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 EEA25324.1 - 0.94 8.6 16.8 1.2 8.2 16.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 EEA25324.1 - 1.1 7.5 9.9 1.1 7.4 9.9 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 EEA25324.1 - 2 8.8 17.2 4.1 7.8 17.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3295 PF11702.8 EEA25324.1 - 2.1 7.6 9.2 2.5 7.4 9.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) YL1 PF05764.13 EEA25324.1 - 3 7.9 13.8 3.9 7.5 13.8 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Astro_capsid_p PF12226.8 EEA25324.1 - 8.8 5.4 12.3 12 5.0 12.3 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CIAPIN1 PF05093.13 EEA25325.1 - 3.5e-39 133.3 5.1 5.6e-39 132.7 5.1 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EEA25325.1 - 6.5e-37 126.7 0.0 9.5e-37 126.2 0.0 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus Thiamine_BP PF01910.17 EEA25326.1 - 3.2e-25 87.9 0.0 3.7e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Thiamine-binding protein FAD_binding_4 PF01565.23 EEA25328.1 - 2.8e-23 82.2 2.5 5.4e-23 81.3 2.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA25328.1 - 0.067 13.3 0.3 0.17 12.0 0.3 1.7 1 0 0 1 1 1 0 Berberine and berberine like AA_permease_2 PF13520.6 EEA25329.1 - 1.6e-49 168.9 51.6 2.3e-49 168.4 51.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA25329.1 - 2.1e-32 112.4 38.9 2.1e-32 112.4 38.9 1.8 2 0 0 2 2 2 1 Amino acid permease Acetyltransf_7 PF13508.7 EEA25331.1 - 1.5e-05 25.3 0.0 3.5e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA25331.1 - 7.5e-05 22.9 0.0 0.00014 22.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA25331.1 - 0.002 18.1 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Isochorismatase PF00857.20 EEA25332.1 - 7.7e-29 101.1 0.0 8.7e-29 100.9 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family Peptidase_S9 PF00326.21 EEA25332.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family AP_endonuc_2 PF01261.24 EEA25333.1 - 5.4e-44 150.2 0.0 7.3e-44 149.7 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel 6PGD PF00393.19 EEA25334.1 - 4.4e-85 285.6 0.0 5.4e-85 285.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EEA25334.1 - 1.8e-34 119.2 0.0 2.8e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EEA25334.1 - 6.9e-08 32.6 0.1 1.2e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EEA25334.1 - 0.00012 22.2 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 EEA25334.1 - 0.0049 16.3 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EEA25334.1 - 0.0049 16.5 0.0 0.0082 15.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EEA25334.1 - 0.022 14.4 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_11 PF14833.6 EEA25334.1 - 0.042 14.1 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Pyr_redox PF00070.27 EEA25334.1 - 0.057 14.0 0.2 0.14 12.8 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA25334.1 - 0.13 12.5 0.2 0.36 11.1 0.2 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Metallophos PF00149.28 EEA25335.1 - 1.2e-12 48.8 0.0 1.8e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF236 PF03057.14 EEA25335.1 - 0.05 13.6 0.8 0.14 12.1 0.8 1.8 1 0 0 1 1 1 0 DUF236 repeat Mucin PF01456.17 EEA25336.1 - 0.0013 18.8 7.9 0.0022 18.0 7.9 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4690 PF15756.5 EEA25336.1 - 0.0013 19.3 2.0 0.0028 18.2 2.0 1.5 1 0 0 1 1 1 1 Small Novel Rich in Cartilage Mid2 PF04478.12 EEA25336.1 - 0.064 13.1 1.2 0.1 12.5 1.2 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Fungal_trans PF04082.18 EEA25338.1 - 5.8e-09 35.4 0.2 3.1e-08 33.0 0.0 2.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25338.1 - 7.7e-08 32.3 9.6 1.8e-07 31.2 9.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PNP_UDP_1 PF01048.20 EEA25339.1 - 7.4e-39 133.4 0.2 9.6e-39 133.0 0.2 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DUF572 PF04502.13 EEA25340.1 - 5.5e-70 236.6 1.1 6.3e-70 236.4 1.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) GTP_CH_N PF12471.8 EEA25340.1 - 0.027 14.2 0.0 0.043 13.6 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase N terminal PTPA PF03095.15 EEA25341.1 - 6.2e-120 400.2 0.0 7.2e-120 400.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein ATG16 PF08614.11 EEA25343.1 - 8.7e-05 22.8 30.0 8.7e-05 22.8 30.0 9.1 1 1 8 9 9 9 2 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EEA25343.1 - 0.002 17.0 12.5 0.002 17.0 12.5 8.9 1 1 11 12 12 12 1 Spc7 kinetochore protein SOAR PF16533.5 EEA25343.1 - 0.0057 16.6 6.7 0.0057 16.6 6.7 10.1 4 2 7 11 11 11 1 STIM1 Orai1-activating region Filament PF00038.21 EEA25343.1 - 0.3 10.6 163.5 3.7 7.1 3.2 8.1 1 1 6 7 7 7 0 Intermediate filament protein ELM2 PF01448.24 EEA25343.1 - 0.95 10.3 6.0 37 5.2 0.2 3.8 3 0 0 3 3 3 0 ELM2 domain DUF3800 PF12686.7 EEA25343.1 - 1.4 9.5 4.7 7.3e+02 0.8 4.7 4.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) ObR_Ig PF18589.1 EEA25343.1 - 9.5 6.7 6.6 4.9 7.6 0.7 3.6 2 0 0 2 2 2 0 Obesity receptor immunoglobulin like domain BUD22 PF09073.10 EEA25344.1 - 1e-108 364.5 37.4 1.2e-108 364.2 37.4 1.0 1 0 0 1 1 1 1 BUD22 ChiC PF06483.11 EEA25344.1 - 0.014 15.3 0.2 0.033 14.1 0.2 1.6 1 0 0 1 1 1 0 Chitinase C Complex1_30kDa PF00329.19 EEA25345.1 - 4.5e-46 156.4 0.0 6.3e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Complex1_30kDa PF00329.19 EEA25346.1 - 4.9e-46 156.3 0.0 7.4e-46 155.7 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit zf-RING_4 PF14570.6 EEA25347.1 - 2.5e-19 68.8 13.3 4.1e-19 68.1 13.3 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EEA25347.1 - 4e-06 26.6 7.7 6.8e-06 25.9 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EEA25347.1 - 0.00068 19.4 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 EEA25347.1 - 0.0012 19.1 11.5 0.0021 18.3 11.5 1.4 1 0 0 1 1 1 1 Ring finger domain Baculo_IE-1 PF05290.11 EEA25347.1 - 0.0016 18.4 5.4 0.0026 17.7 5.4 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 EEA25347.1 - 0.22 11.4 9.6 1.6 8.7 9.9 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EEA25347.1 - 0.23 11.3 12.7 0.44 10.5 12.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF737 PF05300.11 EEA25347.1 - 1.1 9.6 0.0 1.1 9.6 0.0 5.1 3 2 1 4 4 2 0 Protein of unknown function (DUF737) MCLC PF05934.11 EEA25347.1 - 1.2 7.7 5.5 2.3 6.9 5.5 1.3 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) DZR PF12773.7 EEA25347.1 - 2.5 8.2 10.0 53 3.9 10.6 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-RING_UBOX PF13445.6 EEA25347.1 - 5.2 7.2 10.8 11 6.2 10.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger E1_dh PF00676.20 EEA25348.1 - 6.9e-89 297.7 0.0 8.5e-89 297.4 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EEA25348.1 - 0.0014 18.4 0.2 0.023 14.5 0.2 2.3 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Rossmann-like PF10727.9 EEA25348.1 - 0.015 15.1 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 Rossmann-like domain Malate_DH PF12434.8 EEA25348.1 - 0.92 9.6 5.6 3.2 7.9 0.3 2.8 2 0 0 2 2 2 0 Malate dehydrogenase enzyme GST_C PF00043.25 EEA25349.1 - 1.1e-12 47.9 0.0 2e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA25349.1 - 3.3e-11 43.4 0.0 6.2e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA25349.1 - 4.6e-10 39.6 0.0 8.5e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA25349.1 - 6.3e-06 26.4 0.0 7.9e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA25349.1 - 7.9e-06 25.8 0.1 1.4e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA25349.1 - 0.0028 17.9 0.0 0.005 17.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 EEA25349.1 - 0.036 14.7 0.0 0.065 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA25350.1 - 3.2e-11 43.5 0.0 4.8e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA25350.1 - 3.7e-05 24.0 0.0 6.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA25350.1 - 0.0027 18.0 0.0 0.0041 17.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA25351.1 - 1.2e-12 47.8 0.0 2.1e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA25351.1 - 4.6e-10 39.6 0.0 8.7e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA25351.1 - 8e-06 25.8 0.1 1.5e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA25351.1 - 7.5e-05 23.1 0.0 0.00015 22.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 EEA25351.1 - 0.037 14.6 0.0 0.066 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA25351.1 - 0.08 13.3 0.0 1 9.8 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Acetyltransf_1 PF00583.25 EEA25352.1 - 6.9e-13 48.9 0.1 2.3e-12 47.2 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA25352.1 - 5.1e-12 45.8 0.0 8.4e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA25352.1 - 6.7e-12 45.7 0.0 1.6e-11 44.4 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA25352.1 - 2.1e-05 24.6 0.0 0.00039 20.5 0.0 2.3 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA25352.1 - 0.00058 19.9 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EEA25352.1 - 0.0013 19.4 0.0 0.11 13.2 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA25352.1 - 0.0016 18.4 0.0 0.0039 17.1 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein GNAT_acetyltran PF12746.7 EEA25352.1 - 0.032 13.8 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Ig_mannosidase PF17753.1 EEA25354.1 - 2.9e-19 68.6 0.0 1.1e-18 66.7 0.0 2.1 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 EEA25354.1 - 1.7e-13 51.0 0.4 8.2e-12 45.6 0.1 3.0 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EEA25354.1 - 1.5e-10 41.7 0.1 2.5e-09 37.8 0.1 2.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 PEP_mutase PF13714.6 EEA25355.1 - 1.8e-39 135.6 0.1 2.1e-39 135.4 0.1 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EEA25355.1 - 8.6e-22 77.3 0.1 1.1e-21 76.9 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family DUF1275 PF06912.11 EEA25356.1 - 2e-45 155.1 14.6 2.4e-45 154.8 14.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) DUF3040 PF11239.8 EEA25356.1 - 0.53 10.6 5.5 1.4 9.3 0.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) NAD_binding_10 PF13460.6 EEA25357.1 - 1.1e-12 48.3 0.0 1.6e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Aldedh PF00171.22 EEA25358.1 - 2.9e-111 372.3 0.0 3.5e-111 372.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 EEA25359.1 - 1.2e-98 330.6 0.0 1.3e-98 330.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Abhydrolase_1 PF00561.20 EEA25360.1 - 5.2e-23 82.0 0.0 2.9e-21 76.3 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA25360.1 - 1.6e-16 61.6 0.7 2.1e-16 61.2 0.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA25360.1 - 4.6e-09 35.9 0.0 7.3e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EEA25360.1 - 2.4e-07 30.7 0.1 0.0001 22.1 0.0 2.2 1 1 1 2 2 2 2 PGAP1-like protein DUF915 PF06028.11 EEA25360.1 - 0.00051 19.4 0.0 0.37 10.1 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 EEA25360.1 - 0.0022 17.7 0.0 0.0031 17.2 0.0 1.2 1 0 0 1 1 1 1 Putative esterase UPF0227 PF05728.12 EEA25360.1 - 0.0028 17.6 0.0 0.0043 17.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Chlorophyllase PF07224.11 EEA25360.1 - 0.0074 15.3 0.1 0.013 14.5 0.1 1.5 1 1 0 1 1 1 1 Chlorophyllase Thioesterase PF00975.20 EEA25360.1 - 0.0075 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 EEA25360.1 - 0.024 14.5 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EEA25360.1 - 0.025 13.5 0.4 0.055 12.4 0.3 1.8 1 1 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 EEA25360.1 - 0.043 13.6 0.0 0.7 9.6 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase BAAT_C PF08840.11 EEA25360.1 - 0.047 13.6 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF726 PF05277.12 EEA25360.1 - 0.068 12.1 0.0 0.09 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Lipase_2 PF01674.18 EEA25360.1 - 0.17 11.4 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) PAF-AH_p_II PF03403.13 EEA25360.1 - 0.18 10.3 0.1 0.34 9.4 0.0 1.4 1 1 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Palm_thioest PF02089.15 EEA25360.1 - 0.19 11.5 0.0 0.49 10.2 0.0 1.6 2 0 0 2 2 2 0 Palmitoyl protein thioesterase KIX_2 PF16987.5 EEA25362.1 - 1.3e-05 25.1 0.7 2.7e-05 24.0 0.7 1.6 1 0 0 1 1 1 1 KIX domain KIX PF02172.16 EEA25362.1 - 0.033 14.4 0.9 0.054 13.8 0.9 1.3 1 0 0 1 1 1 0 KIX domain Bac_luciferase PF00296.20 EEA25363.1 - 2.5e-59 201.3 0.2 3.4e-59 200.8 0.2 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Glyco_hydro_3_C PF01915.22 EEA25364.1 - 2.1e-46 158.4 0.0 3.5e-46 157.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA25364.1 - 7.7e-45 153.6 0.0 1.2e-44 153.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA25364.1 - 8.7e-20 70.6 0.2 1.5e-19 69.8 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Fungal_trans PF04082.18 EEA25365.1 - 4.5e-08 32.4 2.0 8.9e-07 28.2 2.0 2.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25365.1 - 0.00032 20.8 14.9 0.00057 20.0 14.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3445 PF11927.8 EEA25367.1 - 5.5e-70 235.5 0.0 6.6e-70 235.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Glyco_hydro_79C PF16862.5 EEA25368.1 - 3.3e-14 53.6 0.1 5.4e-14 52.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain ResIII PF04851.15 EEA25369.1 - 0.026 14.5 0.0 0.038 14.0 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit HSP70 PF00012.20 EEA25371.1 - 2.3e-09 36.0 0.2 1.8e-08 33.0 0.2 1.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA25371.1 - 0.024 13.5 0.4 0.14 10.9 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein PAP1 PF08601.10 EEA25373.1 - 0.61 9.8 10.9 0.89 9.2 10.9 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 N2227 PF07942.12 EEA25374.1 - 2e-91 306.0 0.0 2.5e-91 305.7 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_31 PF13847.6 EEA25374.1 - 0.0059 16.4 0.0 0.073 12.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA25374.1 - 0.0084 16.0 0.0 0.017 14.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA25374.1 - 0.018 15.7 0.0 0.066 13.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 EEA25374.1 - 0.048 14.4 0.0 0.24 12.2 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain PAC4 PF16093.5 EEA25375.1 - 1.2e-26 92.7 0.4 1.6e-26 92.3 0.4 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 GAPES4 PF17157.4 EEA25375.1 - 0.14 12.5 0.1 0.28 11.6 0.1 1.5 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain DUF2278 PF10042.9 EEA25377.1 - 2.4e-69 233.5 1.2 3.5e-69 232.9 1.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2278) MFS_1 PF07690.16 EEA25378.1 - 8.8e-37 126.8 53.3 4e-36 124.7 36.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA25378.1 - 6.6e-17 61.5 1.1 6.6e-17 61.5 1.1 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EEA25378.1 - 4.7e-07 29.4 1.8 4.7e-07 29.4 1.8 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EEA25378.1 - 2.8e-05 22.7 1.6 2.8e-05 22.7 1.6 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) FA_desaturase PF00487.24 EEA25378.1 - 1.5 8.6 20.6 0.061 13.1 5.9 2.9 1 1 0 2 2 2 0 Fatty acid desaturase AA_permease PF00324.21 EEA25380.1 - 6.5e-116 387.8 44.5 7.9e-116 387.5 44.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA25380.1 - 1.6e-29 103.0 50.9 3.5e-29 101.9 50.4 1.6 1 1 1 2 2 2 1 Amino acid permease Pkinase PF00069.25 EEA25381.1 - 2.8e-27 95.7 0.0 5.6e-27 94.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25381.1 - 2.4e-06 27.0 0.0 7.1e-06 25.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EEA25381.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Ank_2 PF12796.7 EEA25383.1 - 2.8e-126 412.4 34.1 2.3e-15 56.9 0.7 15.2 4 4 9 16 16 16 16 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA25383.1 - 2.1e-94 308.8 29.7 7.9e-09 35.9 0.1 22.0 8 5 16 24 24 24 22 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA25383.1 - 9.4e-82 268.0 34.2 2.4e-09 37.3 0.1 20.7 10 5 12 22 22 22 19 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA25383.1 - 1.4e-77 246.3 28.1 0.0062 17.0 0.0 28.2 30 0 0 30 30 30 19 Ankyrin repeat Ank PF00023.30 EEA25383.1 - 2.8e-66 217.2 38.5 0.00017 21.9 0.0 24.7 22 2 2 24 24 24 18 Ankyrin repeat SPRY PF00622.28 EEA25383.1 - 1.5e-15 57.4 0.7 3.2e-15 56.3 0.7 1.5 1 0 0 1 1 1 1 SPRY domain Ank_4 PF13637.6 EEA25386.1 - 1.2e-06 29.0 0.0 0.028 15.0 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA25386.1 - 1.2e-05 25.7 0.0 0.025 15.2 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA25386.1 - 0.0014 19.0 0.0 0.19 12.4 0.0 4.2 5 0 0 5 5 5 1 Ankyrin repeat DUF1931 PF09123.11 EEA25386.1 - 0.034 14.3 0.2 0.097 12.8 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1931) Ank PF00023.30 EEA25386.1 - 0.055 13.9 0.0 8.9 7.0 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeat Peptidase_S8 PF00082.22 EEA25387.1 - 2.1e-09 37.1 0.0 5.2e-08 32.5 0.0 2.6 1 1 0 1 1 1 1 Subtilase family Alpha-amylase PF00128.24 EEA25388.1 - 3.9e-21 76.0 0.0 7.5e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 EEA25388.1 - 6.3e-05 21.4 1.1 0.19 9.9 0.0 3.0 3 0 0 3 3 3 2 Glycosyl hydrolase family 70 DUF1947 PF09183.10 EEA25389.1 - 0.063 13.6 0.2 0.3 11.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) PIN_12 PF16289.5 EEA25389.1 - 0.14 12.6 1.0 0.32 11.5 0.2 2.0 2 0 0 2 2 2 0 PIN domain Mito_carr PF00153.27 EEA25390.1 - 1.1e-43 147.0 8.1 4.6e-16 58.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Amidase PF01425.21 EEA25391.1 - 7.3e-94 315.3 0.0 1.2e-93 314.6 0.0 1.3 1 1 0 1 1 1 1 Amidase STAT_alpha PF01017.20 EEA25392.1 - 0.00044 20.2 1.2 0.97 9.3 0.2 2.5 2 0 0 2 2 2 2 STAT protein, all-alpha domain GTP1_OBG PF01018.22 EEA25392.1 - 0.0056 16.3 1.2 0.0056 16.3 1.2 2.6 3 0 0 3 3 3 1 GTP1/OBG p450 PF00067.22 EEA25395.1 - 1.8e-50 172.0 0.0 2.5e-50 171.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CCDC-167 PF15188.6 EEA25397.1 - 0.22 11.9 10.2 0.53 10.6 10.2 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 XRN_M PF17846.1 EEA25397.1 - 4.2 6.2 9.0 5.4 5.9 9.0 1.3 1 0 0 1 1 1 0 Xrn1 helical domain HAUS6_N PF14661.6 EEA25397.1 - 6.1 6.4 9.4 12 5.4 9.4 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus adh_short_C2 PF13561.6 EEA25400.1 - 1.6e-43 148.9 1.0 2.1e-43 148.5 1.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA25400.1 - 2.6e-41 141.3 0.3 4.4e-41 140.5 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA25400.1 - 1.6e-12 47.7 0.4 2.7e-12 46.9 0.4 1.3 1 0 0 1 1 1 1 KR domain Acetyltransf_7 PF13508.7 EEA25401.1 - 1.1e-10 41.8 0.0 2.1e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA25401.1 - 2.8e-10 40.2 0.0 5.9e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA25401.1 - 5.2e-09 36.3 0.1 7.4e-09 35.9 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EEA25401.1 - 0.00032 20.8 0.0 0.0012 18.9 0.0 1.9 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA25401.1 - 0.018 15.0 0.0 0.048 13.6 0.0 1.7 1 1 0 1 1 1 0 FR47-like protein DNA_pol3_tau_5 PF12170.8 EEA25401.1 - 0.054 13.6 0.2 0.12 12.4 0.1 1.6 2 0 0 2 2 2 0 DNA polymerase III tau subunit V interacting with alpha Acetyltransf_CG PF14542.6 EEA25401.1 - 0.18 12.0 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase PAP_central PF04928.17 EEA25402.1 - 5.7e-109 362.9 0.0 7.9e-109 362.4 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EEA25402.1 - 3.8e-59 199.2 0.0 5.6e-59 198.6 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EEA25402.1 - 3.5e-11 43.3 0.0 7.2e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EEA25402.1 - 0.17 11.6 0.1 0.41 10.4 0.1 1.6 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Fungal_trans PF04082.18 EEA25404.1 - 1.9e-22 79.6 0.2 2.8e-20 72.5 0.0 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25404.1 - 7.7e-06 25.9 13.7 1.3e-05 25.2 13.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Say1_Mug180 PF10340.9 EEA25405.1 - 1.2e-26 93.5 0.0 1.7e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EEA25405.1 - 6.1e-23 81.8 0.0 8.4e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA25405.1 - 0.0045 15.9 0.0 0.45 9.3 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Peptidase_S9 PF00326.21 EEA25405.1 - 0.067 12.7 0.0 0.34 10.3 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EEA25405.1 - 0.089 12.6 0.1 4.5 7.0 0.0 2.8 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Say1_Mug180 PF10340.9 EEA25406.1 - 4.7e-26 91.5 0.0 7.4e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EEA25406.1 - 3.8e-20 72.7 0.0 5.6e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA25406.1 - 0.0042 16.0 0.0 0.43 9.4 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Peptidase_S9 PF00326.21 EEA25406.1 - 0.065 12.7 0.0 0.33 10.4 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EEA25406.1 - 0.083 12.7 0.1 4.3 7.1 0.0 2.8 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Cyc-maltodext_N PF09087.11 EEA25406.1 - 0.14 12.4 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 Cyclomaltodextrinase, N-terminal Tri3 PF07428.11 EEA25407.1 - 1.8e-212 705.6 0.0 2.1e-212 705.4 0.0 1.0 1 0 0 1 1 1 1 15-O-acetyltransferase Tri3 AATase PF07247.12 EEA25407.1 - 6.7e-06 24.9 0.3 0.045 12.3 0.0 2.1 2 0 0 2 2 2 2 Alcohol acetyltransferase Flavin_Reduct PF01613.18 EEA25408.1 - 2.4e-20 73.1 0.0 4e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain DUF447 PF04289.12 EEA25408.1 - 0.095 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF447) Mucin PF01456.17 EEA25410.1 - 0.068 13.2 3.5 0.094 12.7 3.5 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Pyr_redox_2 PF07992.14 EEA25411.1 - 7.1e-35 120.6 0.0 4.8e-33 114.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA25411.1 - 7.3e-09 36.1 0.0 5.3e-07 30.1 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA25411.1 - 0.17 12.1 0.0 14 6.0 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain CMD PF02627.20 EEA25412.1 - 0.00027 20.9 0.0 0.0045 17.0 0.0 2.2 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family MFS_1 PF07690.16 EEA25413.1 - 7e-24 84.4 16.8 7e-24 84.4 16.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily HSP20 PF00011.21 EEA25414.1 - 2.1e-11 43.9 2.0 5.1e-11 42.6 0.3 2.0 2 0 0 2 2 2 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EEA25414.1 - 0.00044 19.7 0.0 0.035 13.7 0.0 2.9 3 0 0 3 3 3 1 HSP20-like domain found in ArsA ExbD PF02472.16 EEA25414.1 - 0.11 12.6 1.7 0.19 11.9 1.7 1.3 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR Ank_2 PF12796.7 EEA25417.1 - 9.6e-48 160.7 0.0 3.1e-15 56.5 0.1 4.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA25417.1 - 1.7e-42 143.2 5.9 1e-11 45.1 0.2 7.3 4 2 3 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EEA25417.1 - 5.6e-38 127.8 2.0 3.6e-05 24.0 0.0 9.2 9 0 0 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 EEA25417.1 - 1.4e-33 111.1 1.9 0.00017 21.8 0.0 9.1 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EEA25417.1 - 5.1e-28 96.8 5.3 6.2e-06 26.4 0.0 7.9 3 2 5 8 8 8 7 Ankyrin repeats (many copies) CorA PF01544.18 EEA25417.1 - 1.6e-13 50.6 1.0 4.4e-13 49.2 0.6 1.9 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein CENP-B_N PF04218.13 EEA25417.1 - 0.067 12.8 0.1 0.73 9.5 0.0 2.4 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain GLE1 PF07817.13 EEA25417.1 - 0.1 11.8 0.5 0.21 10.7 0.5 1.5 1 0 0 1 1 1 0 GLE1-like protein HBS1_N PF08938.10 EEA25417.1 - 0.7 10.2 4.5 2.1 8.7 4.5 1.9 1 0 0 1 1 1 0 HBS1 N-terminus A_deaminase PF00962.22 EEA25418.1 - 5.2e-39 134.5 0.0 6e-39 134.3 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 EEA25418.1 - 0.00052 19.4 0.0 0.00077 18.9 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase family DUF2764 PF10962.8 EEA25418.1 - 0.16 11.5 0.1 0.24 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2764) MFS_1 PF07690.16 EEA25419.1 - 2.4e-33 115.6 31.5 2.4e-33 115.6 31.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA25419.1 - 1.6e-05 24.4 17.9 3.8e-05 23.2 4.7 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Caskin1-CID PF16600.5 EEA25420.1 - 3 8.5 6.2 0.52 10.9 1.1 2.3 2 0 0 2 2 2 0 Caskin1 CASK-interaction domain RVT_2 PF07727.14 EEA25421.1 - 6.3e-07 29.3 0.0 1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA25421.1 - 0.00039 20.6 0.0 0.0013 18.9 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Podoplanin PF05808.11 EEA25423.1 - 0.007 16.5 0.2 0.007 16.5 0.2 2.6 3 0 0 3 3 3 1 Podoplanin DUF5305 PF17231.2 EEA25423.1 - 0.12 11.7 0.0 0.46 9.8 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5305) TRI5 PF06330.11 EEA25425.1 - 3.4e-28 98.5 0.4 4.7e-28 98.1 0.4 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) p450 PF00067.22 EEA25426.1 - 1.3e-76 258.3 0.0 1.5e-76 258.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_transf_22 PF03901.17 EEA25426.1 - 0.028 13.7 0.3 0.04 13.1 0.3 1.2 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family TaqI_C PF12950.7 EEA25426.1 - 0.064 13.3 0.1 0.35 10.9 0.0 2.2 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain MFS_1 PF07690.16 EEA25427.1 - 3.3e-31 108.5 54.0 3.3e-31 108.5 54.0 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA25427.1 - 4e-09 35.8 12.0 4e-09 35.8 12.0 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter DUF485 PF04341.12 EEA25427.1 - 0.028 14.4 1.0 0.028 14.4 1.0 3.6 3 0 0 3 3 3 0 Protein of unknown function, DUF485 DEFB136 PF17333.2 EEA25427.1 - 6.4 6.8 6.0 0.93 9.5 1.5 1.9 2 0 0 2 2 2 0 Beta defensin 136 DDE_Tnp_1_7 PF13843.6 EEA25428.1 - 5e-52 177.3 0.0 6.4e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA25428.1 - 6.6e-12 46.0 9.4 1.5e-11 44.9 9.4 1.7 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon Aminotran_1_2 PF00155.21 EEA25429.1 - 1.4e-14 54.1 0.0 1.7e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Pectate_lyase_3 PF12708.7 EEA25430.1 - 2.3e-104 347.9 10.4 9.3e-88 293.6 8.1 2.7 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EEA25430.1 - 4.2e-07 29.6 2.3 0.02 14.6 0.1 2.9 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase FMO-like PF00743.19 EEA25431.1 - 1.6e-10 40.1 0.1 6.1e-10 38.1 0.1 1.8 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EEA25431.1 - 7.1e-10 38.5 0.0 3.2e-07 29.8 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EEA25431.1 - 2e-09 37.2 0.0 2.6e-07 30.2 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA25431.1 - 3.5e-09 36.3 0.0 2.6e-06 26.9 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA25431.1 - 2.2e-08 34.2 0.2 6.7e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA25431.1 - 5.6e-06 26.4 1.4 0.00088 19.3 0.0 3.8 4 1 0 4 4 4 1 FAD-NAD(P)-binding Thi4 PF01946.17 EEA25431.1 - 0.054 12.7 0.0 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 Thi4 family Shikimate_DH PF01488.20 EEA25431.1 - 0.1 12.7 0.2 21 5.2 0.0 3.7 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EEA25432.1 - 6.4e-65 219.7 0.0 1.1e-63 215.6 0.0 2.5 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EEA25432.1 - 3.8e-31 108.4 0.0 6.9e-31 107.5 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain SE PF08491.10 EEA25432.1 - 0.0011 18.1 0.0 0.098 11.7 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase NAD_binding_8 PF13450.6 EEA25432.1 - 0.021 15.1 0.1 0.069 13.4 0.1 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA25432.1 - 0.037 13.2 0.0 0.12 11.6 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA25432.1 - 0.054 12.2 0.0 0.084 11.6 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 EEA25432.1 - 0.14 11.3 0.2 0.42 9.6 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain FAD_binding_4 PF01565.23 EEA25433.1 - 4.6e-22 78.2 0.0 8.2e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EEA25433.1 - 1.4e-14 54.3 0.0 2.2e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain ADH_zinc_N PF00107.26 EEA25434.1 - 5.8e-26 91.0 0.1 1.1e-25 90.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA25434.1 - 9.6e-19 67.3 0.1 2.2e-18 66.1 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 EEA25434.1 - 3.5e-10 39.7 0.1 7e-10 38.8 0.1 1.4 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EEA25434.1 - 2e-05 24.0 0.7 3.5e-05 23.2 0.7 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EEA25434.1 - 0.00014 22.9 0.1 0.0017 19.4 0.0 2.6 1 1 1 2 2 2 1 Zinc-binding dehydrogenase FAD_binding_2 PF00890.24 EEA25434.1 - 0.027 13.5 0.8 0.039 13.0 0.8 1.2 1 0 0 1 1 1 0 FAD binding domain PALP PF00291.25 EEA25434.1 - 0.028 13.8 0.3 0.041 13.3 0.3 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Methyltransf_25 PF13649.6 EEA25434.1 - 0.1 13.3 0.0 0.44 11.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Fungal_trans PF04082.18 EEA25435.1 - 9e-08 31.5 0.0 2.4e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_31 PF13847.6 EEA25436.1 - 2e-06 27.7 0.3 4.3e-06 26.6 0.3 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA25436.1 - 3.4e-06 27.7 0.0 7.6e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EEA25436.1 - 1.3e-05 25.1 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EEA25436.1 - 0.0015 17.9 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EEA25436.1 - 0.0019 18.0 0.0 0.0069 16.1 0.0 1.8 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_24 PF13578.6 EEA25436.1 - 0.002 19.1 0.0 0.0037 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA25436.1 - 0.0032 18.2 0.0 0.0095 16.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Fibrillarin PF01269.17 EEA25436.1 - 0.0065 15.6 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Fibrillarin Methyltransf_3 PF01596.17 EEA25436.1 - 0.0084 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.6 EEA25436.1 - 0.012 15.5 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain SoPB_HTH PF18090.1 EEA25436.1 - 0.022 14.9 0.0 0.056 13.6 0.0 1.7 1 0 0 1 1 1 0 Centromere-binding protein HTH domain TPR_10 PF13374.6 EEA25436.1 - 0.029 14.2 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat CMAS PF02353.20 EEA25436.1 - 0.04 13.2 0.1 0.07 12.4 0.1 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EEA25436.1 - 0.057 14.1 0.1 0.23 12.1 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain TehB PF03848.14 EEA25436.1 - 0.13 11.6 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB AA_permease PF00324.21 EEA25437.1 - 2.4e-51 174.8 28.4 2.9e-51 174.6 28.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA25437.1 - 8e-19 67.8 32.4 1.1e-18 67.3 32.4 1.2 1 0 0 1 1 1 1 Amino acid permease DUF2556 PF10831.8 EEA25437.1 - 0.88 9.6 4.4 3.1 7.8 4.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) NDUF_B12 PF08122.12 EEA25437.1 - 1.4 9.0 4.7 4.2 7.5 0.0 3.5 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF2631 PF10939.8 EEA25437.1 - 7.7 6.4 6.2 13 5.7 0.6 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2631) Asp PF00026.23 EEA25438.1 - 2.9e-38 132.1 0.0 3.4e-38 131.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA25438.1 - 0.041 14.5 0.0 20 5.9 0.0 3.3 3 0 0 3 3 3 0 Aspartyl protease DAO PF01266.24 EEA25439.1 - 7.8e-23 81.6 0.0 9.6e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase tRNA-synt_1b PF00579.25 EEA25440.1 - 5e-55 186.9 0.0 6.2e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Epimerase PF01370.21 EEA25440.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family IMPa_helical PF18642.1 EEA25440.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Immunomodulating metalloprotease helical domain Cation_efflux PF01545.21 EEA25441.1 - 6.1e-14 52.2 9.2 8e-14 51.8 9.2 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EEA25441.1 - 9e-10 38.6 0.2 2.3e-09 37.2 0.2 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter GAT PF03127.14 EEA25442.1 - 7.6e-15 55.0 2.5 2.1e-14 53.6 0.5 2.2 2 0 0 2 2 2 1 GAT domain VHS PF00790.19 EEA25442.1 - 0.0059 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EEA25443.1 - 4.3e-15 55.8 2.5 1.4e-14 54.1 0.5 2.2 2 0 0 2 2 2 1 GAT domain SIKE PF05769.11 EEA25443.1 - 0.14 12.1 0.4 0.26 11.2 0.4 1.4 1 0 0 1 1 1 0 SIKE family Ribosomal_L22 PF00237.19 EEA25444.1 - 2.7e-41 140.0 0.1 4.2e-41 139.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e 2-Hacid_dh_C PF02826.19 EEA25445.1 - 9e-56 188.0 0.0 1.7e-55 187.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA25445.1 - 4.1e-17 62.1 0.0 5e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA25445.1 - 0.00092 19.4 0.5 0.0021 18.3 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EEA25445.1 - 0.082 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ADH_N PF08240.12 EEA25446.1 - 1e-27 96.2 0.2 1.7e-27 95.4 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA25446.1 - 1.4e-13 51.0 0.2 6.4e-13 48.8 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA25446.1 - 6.3e-13 48.7 0.3 3.4e-06 26.7 0.0 2.2 1 1 1 2 2 2 2 Glucose dehydrogenase C-terminus ApbA PF02558.16 EEA25446.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 EEA25446.1 - 0.026 14.8 0.1 0.068 13.4 0.0 1.8 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EEA25446.1 - 0.13 11.8 0.5 0.25 10.9 0.0 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain adh_short_C2 PF13561.6 EEA25447.1 - 8.5e-47 159.7 0.1 9.6e-47 159.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA25447.1 - 1e-44 152.3 0.1 1.3e-44 152.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA25447.1 - 4.7e-12 46.2 0.1 6.5e-12 45.7 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA25447.1 - 2e-05 24.2 0.1 4.4e-05 23.1 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA25447.1 - 2.7e-05 23.7 0.0 3.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EEA25447.1 - 5.9e-05 23.0 0.0 0.00016 21.6 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EEA25447.1 - 0.0018 17.5 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein YjeF_N PF03853.15 EEA25447.1 - 0.09 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus RmlD_sub_bind PF04321.17 EEA25447.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Fungal_trans PF04082.18 EEA25448.1 - 1.3e-08 34.3 0.6 1.1e-07 31.2 0.6 2.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25448.1 - 7.9e-07 29.1 6.2 1.5e-06 28.2 6.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain K_channel_TID PF07941.11 EEA25448.1 - 0.045 14.2 3.4 0.11 12.9 3.4 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain RNR_inhib PF08591.10 EEA25448.1 - 2.6 9.4 6.1 0.39 12.1 0.2 2.5 2 1 0 2 2 2 0 Ribonucleotide reductase inhibitor adh_short_C2 PF13561.6 EEA25449.1 - 1.2e-55 188.6 0.1 1.5e-55 188.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA25449.1 - 2.5e-52 177.2 0.2 4.8e-52 176.3 0.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA25449.1 - 5e-10 39.6 0.3 8.6e-10 38.8 0.1 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EEA25449.1 - 4.7e-08 32.8 0.0 6.7e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA25449.1 - 0.00016 21.2 0.0 0.00023 20.7 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EEA25449.1 - 0.00044 19.4 0.4 0.0015 17.7 0.2 2.0 2 1 0 2 2 2 1 RmlD substrate binding domain ADH_zinc_N PF00107.26 EEA25449.1 - 0.001 19.0 0.1 0.0023 17.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.6 EEA25449.1 - 0.017 15.5 0.1 0.076 13.5 0.1 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding Glyco_transf_5 PF08323.11 EEA25449.1 - 0.035 13.8 0.0 0.45 10.2 0.0 2.1 2 0 0 2 2 2 0 Starch synthase catalytic domain THF_DHG_CYH_C PF02882.19 EEA25449.1 - 0.057 12.7 0.1 0.13 11.6 0.1 1.6 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.16 EEA25449.1 - 0.069 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Glyco_transf_4 PF13439.6 EEA25449.1 - 0.12 12.3 0.0 4.7 7.2 0.0 2.3 2 1 0 2 2 2 0 Glycosyltransferase Family 4 NmrA PF05368.13 EEA25449.1 - 0.14 11.7 0.6 0.27 10.8 0.6 1.4 1 0 0 1 1 1 0 NmrA-like family Ferric_reduct PF01794.19 EEA25450.1 - 4.8e-26 91.3 7.3 1.4e-25 89.9 7.3 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EEA25450.1 - 1.1e-14 54.9 0.1 2.8e-11 43.8 0.0 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EEA25450.1 - 8.7e-11 41.9 0.2 9.7e-06 25.6 0.2 2.6 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 EEA25450.1 - 0.18 12.5 0.0 0.44 11.2 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain UBA_4 PF14555.6 EEA25451.1 - 3.6e-13 49.1 0.0 8e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EEA25451.1 - 3.1e-10 40.1 0.0 7.8e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 UBX domain DUF1682 PF07946.14 EEA25451.1 - 0.51 9.5 8.3 0.86 8.8 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pan3_PK PF18101.1 EEA25452.1 - 5.7e-63 211.0 1.1 9.4e-63 210.3 1.1 1.4 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EEA25452.1 - 8.1e-07 28.7 0.0 1.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25452.1 - 0.0065 15.8 0.1 0.01 15.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pan3_PK PF18101.1 EEA25453.1 - 1.1e-62 210.0 1.1 1.8e-62 209.4 1.1 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EEA25453.1 - 1.6e-06 27.7 0.0 2.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25453.1 - 0.012 14.9 0.1 0.019 14.3 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase LSM PF01423.22 EEA25454.1 - 3.3e-20 71.5 0.2 4.3e-20 71.2 0.2 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA25454.1 - 0.023 14.8 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Zn_clus PF00172.18 EEA25455.1 - 0.027 14.6 9.7 0.06 13.5 9.7 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Dioxygenase_C PF00775.21 EEA25456.1 - 4.7e-43 146.7 0.0 6.7e-43 146.2 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EEA25456.1 - 3.5e-32 110.1 0.0 6.6e-32 109.2 0.0 1.5 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 EEA25456.1 - 0.009 16.3 0.0 0.044 14.1 0.0 2.1 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain Vps39_2 PF10367.9 EEA25457.1 - 4.7e-08 33.4 0.0 4.1e-07 30.4 0.0 2.5 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 EEA25457.1 - 0.00012 22.3 0.2 0.006 16.9 0.0 3.0 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 CASP_C PF08172.12 EEA25458.1 - 1.4e-88 296.5 2.0 1.4e-88 296.5 2.0 3.7 3 1 0 3 3 3 1 CASP C terminal Fez1 PF06818.15 EEA25458.1 - 0.052 14.0 0.7 0.052 14.0 0.7 4.6 4 1 0 4 4 4 0 Fez1 FliD_C PF07195.12 EEA25458.1 - 0.47 9.8 21.3 0.023 14.1 2.2 3.9 3 1 0 3 3 3 0 Flagellar hook-associated protein 2 C-terminus K_channel_TID PF07941.11 EEA25458.1 - 1.1 9.8 13.2 1.9 9.0 7.9 2.6 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain NAD_binding_1 PF00175.21 EEA25458.1 - 2 9.1 6.1 2.7 8.7 0.0 3.5 4 0 0 4 4 4 0 Oxidoreductase NAD-binding domain betaPIX_CC PF16523.5 EEA25458.1 - 2.6 7.9 22.0 1.2 9.0 5.4 4.3 3 1 0 3 3 3 0 betaPIX coiled coil LIF_OSM PF01291.17 EEA25458.1 - 3.4 7.8 6.5 40 4.3 0.0 4.3 5 0 0 5 5 5 0 LIF / OSM family Fib_alpha PF08702.10 EEA25458.1 - 3.7 7.7 28.0 0.026 14.7 8.6 3.9 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family HALZ PF02183.18 EEA25458.1 - 4.7 7.5 17.4 3.1 8.1 0.1 5.2 4 1 1 5 5 5 0 Homeobox associated leucine zipper Peptidase_M16 PF00675.20 EEA25459.1 - 5.4e-56 188.7 1.1 8.5e-56 188.1 0.5 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA25459.1 - 4.3e-36 124.6 0.0 6.1e-35 120.9 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain MccV PF17508.2 EEA25459.1 - 0.14 12.7 0.1 11 6.7 0.0 2.5 2 0 0 2 2 2 0 Microcin V bacteriocin Epimerase PF01370.21 EEA25460.1 - 4.5e-19 68.9 0.0 5.7e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA25460.1 - 1.5e-12 47.1 0.0 1.9e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA25460.1 - 2.2e-07 30.6 0.0 4.2e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EEA25460.1 - 0.00013 21.2 0.0 0.00022 20.5 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 EEA25460.1 - 0.00048 20.4 0.0 0.00074 19.8 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 EEA25460.1 - 0.001 18.3 0.0 0.069 12.3 0.0 2.6 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 EEA25460.1 - 0.0015 18.0 0.0 0.035 13.6 0.0 2.4 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 EEA25460.1 - 0.0043 17.0 0.0 0.0065 16.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EEA25460.1 - 0.0061 15.7 0.0 0.017 14.3 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Cytochrome-c551 PF10643.9 EEA25460.1 - 0.16 11.6 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 FAD_binding_3 PF01494.19 EEA25461.1 - 1.6e-18 67.1 0.0 5.6e-11 42.3 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EEA25461.1 - 1.8e-06 27.4 0.0 0.0068 15.7 0.3 2.4 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA25461.1 - 2.1e-06 27.9 0.5 4.5e-06 26.8 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA25461.1 - 1.6e-05 24.2 1.0 0.0045 16.1 2.4 2.2 1 1 1 2 2 2 2 FAD binding domain DAO PF01266.24 EEA25461.1 - 1.7e-05 24.6 0.7 0.012 15.2 0.9 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase ThiF PF00899.21 EEA25461.1 - 0.012 15.0 0.9 0.017 14.5 0.1 1.7 2 0 0 2 2 2 0 ThiF family Pyr_redox PF00070.27 EEA25461.1 - 0.012 16.1 0.1 0.82 10.3 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EEA25461.1 - 0.018 13.9 0.1 0.026 13.4 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EEA25461.1 - 0.024 13.9 0.3 0.045 13.0 0.3 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EEA25461.1 - 0.061 12.6 0.8 0.29 10.3 0.5 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA25461.1 - 0.095 11.8 0.4 0.15 11.1 0.4 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EEA25461.1 - 0.12 11.7 0.4 0.34 10.2 0.4 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase Fibrillarin PF01269.17 EEA25462.1 - 2.4e-104 347.4 0.0 2.9e-104 347.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EEA25462.1 - 4.5e-06 26.5 0.1 8.3e-06 25.7 0.1 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 EEA25462.1 - 0.018 14.7 0.0 0.041 13.5 0.0 1.6 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 EEA25462.1 - 0.043 13.6 0.0 0.062 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3455 PF11937.8 EEA25463.1 - 5e-47 160.2 1.3 7e-47 159.7 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) DUF2990 PF11693.8 EEA25463.1 - 3e-19 68.9 1.5 5.8e-19 68.0 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2990) DUF2976 PF11190.8 EEA25463.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) ADH_N_2 PF16884.5 EEA25464.1 - 1.3e-23 82.9 0.0 2.1e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EEA25464.1 - 3.2e-21 75.7 0.0 4.5e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA25464.1 - 5.8e-11 43.6 0.0 1e-10 42.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CybS PF05328.12 EEA25465.1 - 3.3e-50 169.2 0.0 4.5e-50 168.8 0.0 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Sdh_cyt PF01127.22 EEA25465.1 - 0.16 12.0 1.7 1.7 8.7 1.7 2.1 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit CybS PF05328.12 EEA25466.1 - 2e-27 95.5 0.0 3.1e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Maf PF02545.14 EEA25467.1 - 1.2e-45 155.4 0.0 1.4e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein GFA PF04828.14 EEA25468.1 - 0.0036 17.6 0.0 0.035 14.4 0.0 2.4 2 1 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_2 PF13240.6 EEA25468.1 - 0.025 14.3 0.9 0.065 13.0 0.9 1.7 1 0 0 1 1 1 0 zinc-ribbon domain HLH PF00010.26 EEA25469.1 - 2.8e-08 33.6 0.0 5e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Umbravirus_LDM PF04817.12 EEA25469.1 - 0.0093 15.3 0.1 0.01 15.2 0.1 1.1 1 0 0 1 1 1 1 Umbravirus long distance movement (LDM) family Med9 PF07544.13 EEA25469.1 - 0.011 15.8 0.4 0.024 14.7 0.1 1.7 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 MIG-14_Wnt-bd PF06664.12 EEA25471.1 - 0.028 13.7 12.1 0.052 12.8 12.1 1.4 1 1 0 1 1 1 0 Wnt-binding factor required for Wnt secretion DUF4079 PF13301.6 EEA25471.1 - 0.27 11.4 4.0 1.2 9.3 2.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) DUF3671 PF12420.8 EEA25471.1 - 6.4 6.9 9.7 3.1 7.9 4.3 2.9 3 1 0 3 3 3 0 Protein of unknown function Fungal_trans_2 PF11951.8 EEA25472.1 - 4.8e-11 42.1 0.3 9.5e-11 41.1 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25472.1 - 2.4e-08 34.0 8.9 4.5e-08 33.1 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VWA_2 PF13519.6 EEA25473.1 - 0.0027 18.3 0.0 0.014 16.1 0.0 2.3 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EEA25473.1 - 0.0029 17.9 0.0 0.055 13.7 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain ANAPC4 PF12896.7 EEA25475.1 - 1.2e-69 233.9 2.3 1.7e-69 233.4 2.3 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EEA25475.1 - 4.9e-31 106.9 0.0 3.7e-30 104.1 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT_EZ PF13513.6 EEA25476.1 - 1e-12 48.3 10.7 2.9e-08 34.0 0.0 7.2 8 0 0 8 8 8 2 HEAT-like repeat HEAT PF02985.22 EEA25476.1 - 5.3e-12 44.9 12.7 3.7e-05 23.6 0.1 8.6 9 1 0 9 9 9 2 HEAT repeat IBN_N PF03810.19 EEA25476.1 - 2.9e-08 33.5 3.7 9.2e-08 31.9 0.2 3.7 5 0 0 5 5 5 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EEA25476.1 - 4.4e-08 33.4 11.6 0.00083 19.7 0.1 6.7 4 2 4 8 8 8 4 HEAT repeats CLASP_N PF12348.8 EEA25476.1 - 3.6e-05 23.4 0.1 0.057 13.0 0.0 3.9 2 1 0 3 3 3 1 CLASP N terminal DUF3338 PF11819.8 EEA25476.1 - 0.1 12.6 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3338) ADSL_C PF10397.9 EEA25476.1 - 0.21 12.2 1.2 1.1 9.9 0.1 2.5 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus Arm PF00514.23 EEA25476.1 - 2.4 8.3 5.4 1.1e+02 3.1 0.0 4.8 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Ribosomal_S8 PF00410.19 EEA25477.1 - 5.1e-21 74.9 0.1 7.6e-21 74.4 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S8 PF00410.19 EEA25478.1 - 5.1e-21 74.9 0.1 7.6e-21 74.4 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 His_Phos_1 PF00300.22 EEA25479.1 - 1.4e-14 54.3 0.0 3.6e-12 46.4 0.0 2.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lactamase_B_2 PF12706.7 EEA25480.1 - 1.6e-12 47.4 0.0 2.5e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EEA25480.1 - 1.2e-07 31.8 0.0 3.9e-07 30.1 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Zn_clus PF00172.18 EEA25481.1 - 4.3e-06 26.8 7.1 7.6e-06 25.9 7.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ubiquitin PF00240.23 EEA25482.1 - 2.9e-06 26.9 0.0 5.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EEA25482.1 - 0.015 15.8 0.0 0.086 13.4 0.0 2.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain PS_Dcarbxylase PF02666.15 EEA25483.1 - 3.2e-81 271.6 0.0 3.3e-80 268.4 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Pkinase PF00069.25 EEA25484.1 - 3.9e-17 62.5 0.0 2e-16 60.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25484.1 - 1.4e-05 24.5 0.0 0.00011 21.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase ANAPC10 PF03256.16 EEA25485.1 - 1.8e-41 141.8 0.0 2.6e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Iso_dh PF00180.20 EEA25486.1 - 3.5e-123 411.2 0.0 4e-123 411.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CDP-OH_P_transf PF01066.21 EEA25487.1 - 4e-13 49.9 0.5 1.4e-12 48.1 0.5 2.0 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase DIT1_PvcA PF05141.12 EEA25488.1 - 2.2e-91 306.1 0.0 3.6e-91 305.5 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein PP2C PF00481.21 EEA25488.1 - 1.6e-33 116.5 0.0 1.7e-27 96.7 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C AMP-binding PF00501.28 EEA25488.1 - 6.2e-30 104.1 0.0 9.6e-30 103.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Transferase PF02458.15 EEA25488.1 - 4e-08 32.4 0.0 0.013 14.2 0.0 3.1 3 0 0 3 3 3 3 Transferase family PP-binding PF00550.25 EEA25488.1 - 0.00067 20.0 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP2C_2 PF13672.6 EEA25488.1 - 0.0057 16.3 0.0 0.094 12.3 0.0 2.5 2 0 0 2 2 2 1 Protein phosphatase 2C MFS_1 PF07690.16 EEA25489.1 - 6.5e-43 147.0 59.5 1.4e-40 139.3 59.9 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA25489.1 - 1e-09 37.8 34.7 4e-08 32.6 14.5 2.8 1 1 2 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EEA25489.1 - 3.1e-06 25.9 14.0 3.1e-06 25.9 14.0 2.3 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF3989 PF13150.6 EEA25489.1 - 0.11 12.2 0.1 11 5.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) SelK_SelG PF10961.8 EEA25489.1 - 0.14 12.8 0.6 0.56 10.9 0.2 2.3 1 1 0 1 1 1 0 Selenoprotein SelK_SelG OATP PF03137.20 EEA25489.1 - 4.6 5.4 11.2 0.4 8.9 1.0 2.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EEA25490.1 - 3.9e-23 82.0 48.7 3.1e-21 75.7 47.3 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Fez1 PF06818.15 EEA25491.1 - 0.024 15.1 6.6 0.042 14.3 6.6 1.3 1 0 0 1 1 1 0 Fez1 ATG16 PF08614.11 EEA25491.1 - 0.074 13.3 10.6 0.18 12.0 10.6 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Cob_adeno_trans PF01923.18 EEA25491.1 - 0.45 10.7 3.6 0.45 10.6 2.3 1.6 2 0 0 2 2 2 0 Cobalamin adenosyltransferase Atg14 PF10186.9 EEA25491.1 - 0.84 8.7 9.0 1.3 8.0 9.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Csm1_N PF18504.1 EEA25491.1 - 2.4 8.5 9.6 6.8 7.1 0.9 2.7 3 0 0 3 3 2 0 Csm1 N-terminal domain DUF16 PF01519.16 EEA25491.1 - 2.7 8.5 11.8 6.7 7.3 9.3 2.5 2 1 0 2 2 1 0 Protein of unknown function DUF16 TMF_DNA_bd PF12329.8 EEA25491.1 - 2.7 8.0 12.3 4 7.5 0.3 3.0 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 EEA25491.1 - 3.2 6.6 15.0 0.71 8.7 11.4 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF724 PF05266.14 EEA25491.1 - 3.4 7.5 8.8 6.1 6.6 8.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 EEA25491.1 - 4.3 7.4 12.3 1.7 8.7 4.8 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein FAM76 PF16046.5 EEA25491.1 - 5.2 6.3 6.2 10 5.3 6.2 1.4 1 0 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 EEA25491.1 - 6.6 6.0 6.4 11 5.3 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1640 PF07798.11 EEA25491.1 - 7.4 6.6 13.8 2.6 8.0 9.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) RRM_1 PF00076.22 EEA25492.1 - 1.3e-42 143.4 0.5 1.9e-20 72.4 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EEA25492.1 - 5.7e-24 85.0 0.1 1.8e-23 83.5 0.1 1.9 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EEA25492.1 - 2.5e-05 24.1 0.0 0.042 13.7 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 EEA25492.1 - 0.0067 16.5 0.0 0.024 14.7 0.0 2.0 1 0 0 1 1 1 1 RNA binding motif PHM7_cyt PF14703.6 EEA25492.1 - 0.015 15.5 0.1 3.3 7.9 0.0 3.0 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EEA25492.1 - 0.056 13.6 0.1 2 8.6 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif RRM_5 PF13893.6 EEA25492.1 - 0.081 12.5 0.0 0.76 9.4 0.0 2.1 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP PF17069.5 EEA25492.1 - 0.28 10.7 38.6 0.42 10.1 38.6 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Cyt-b5 PF00173.28 EEA25493.1 - 1.3e-19 70.1 2.2 3.1e-19 68.9 0.1 2.2 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EEA25493.1 - 9e-14 52.0 15.8 2.2e-13 50.7 15.8 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Pox_Ag35 PF03286.14 EEA25494.1 - 0.23 11.2 2.1 0.46 10.2 2.1 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Fungal_trans PF04082.18 EEA25495.1 - 4.1e-21 75.2 1.0 7.2e-21 74.4 1.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25495.1 - 9.3e-05 22.5 16.2 9.3e-05 22.5 16.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3782 PF12644.7 EEA25495.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) Zn_clus PF00172.18 EEA25496.1 - 0.035 14.2 9.3 0.067 13.3 9.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Adap_comp_sub PF00928.21 EEA25497.1 - 5.9e-19 68.5 0.0 8e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EEA25497.1 - 2e-06 27.8 0.1 3.4e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 EEA25497.1 - 0.00054 20.4 0.2 0.0012 19.2 0.2 1.6 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) muHD PF10291.9 EEA25497.1 - 0.00086 18.8 0.0 0.0017 17.8 0.0 1.4 1 1 0 1 1 1 1 Muniscin C-terminal mu homology domain DUF2420 PF10336.9 EEA25498.1 - 9e-19 67.5 0.1 2.6e-18 66.0 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Mg_trans_NIPA PF05653.14 EEA25499.1 - 2.6e-104 348.5 14.5 3.1e-104 348.3 14.5 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EEA25499.1 - 0.00011 22.4 5.8 0.00011 22.4 5.8 3.2 2 1 1 3 3 3 2 EamA-like transporter family Acyl_transf_3 PF01757.22 EEA25499.1 - 0.4 9.7 15.3 7.4 5.5 12.4 2.3 1 1 1 2 2 2 0 Acyltransferase family AgrB PF04647.15 EEA25499.1 - 3.3 7.0 15.1 0.46 9.8 6.4 3.0 1 1 1 3 3 3 0 Accessory gene regulator B Syja_N PF02383.18 EEA25501.1 - 8.5e-92 307.9 0.0 1.6e-91 307.0 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EEA25501.1 - 1.6e-40 137.4 0.0 3.6e-40 136.3 0.0 1.6 1 0 0 1 1 1 1 Inositol phosphatase SnoaL_4 PF13577.6 EEA25501.1 - 6.5e-05 23.1 0.0 0.00015 21.8 0.0 1.7 1 0 0 1 1 1 1 SnoaL-like domain HEAT_EZ PF13513.6 EEA25502.1 - 2.9e-38 129.8 8.0 2.1e-16 60.1 0.0 10.2 8 3 3 11 11 10 7 HEAT-like repeat HEAT PF02985.22 EEA25502.1 - 7e-29 97.4 13.1 8.5e-06 25.6 0.0 11.4 12 0 0 12 12 11 5 HEAT repeat HEAT_2 PF13646.6 EEA25502.1 - 1.6e-19 70.0 2.9 0.0011 19.3 0.0 8.4 8 2 2 10 10 10 5 HEAT repeats Cnd1 PF12717.7 EEA25502.1 - 5.3e-15 55.8 0.1 4.5e-05 23.5 0.0 5.0 4 1 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EEA25502.1 - 2.7e-09 37.5 0.0 0.4 11.3 0.0 6.8 5 2 4 9 9 8 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EEA25502.1 - 3.5e-08 32.5 0.1 0.0012 17.5 0.0 4.0 2 2 1 4 4 4 2 Adaptin N terminal region Arm PF00514.23 EEA25502.1 - 2.5e-07 30.5 2.9 0.39 10.8 0.0 6.6 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EEA25502.1 - 3.2e-07 30.2 0.0 4.1 6.9 0.0 6.5 4 3 2 6 6 6 2 CLASP N terminal MMS19_C PF12460.8 EEA25502.1 - 1.2e-06 27.9 5.0 0.091 11.9 0.0 5.2 5 1 0 6 6 6 1 RNAPII transcription regulator C-terminal IBN_N PF03810.19 EEA25502.1 - 2e-05 24.4 0.3 0.12 12.3 0.0 5.1 4 1 1 5 5 3 1 Importin-beta N-terminal domain DRIM PF07539.12 EEA25502.1 - 0.00015 20.2 0.0 0.024 12.9 0.0 3.8 3 1 0 4 4 4 1 Down-regulated in metastasis Xpo1 PF08389.12 EEA25502.1 - 0.0017 18.4 1.7 2.2 8.3 0.0 4.8 3 2 0 3 3 3 1 Exportin 1-like protein DUF3437 PF11919.8 EEA25502.1 - 0.0025 17.7 0.1 0.55 10.2 0.0 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) Tti2 PF10521.9 EEA25502.1 - 0.0048 16.5 0.9 18 4.8 0.0 4.4 3 1 2 5 5 5 0 Tti2 family RIX1 PF08167.12 EEA25502.1 - 0.005 16.6 0.0 3.6 7.3 0.0 4.4 5 1 0 5 5 5 1 rRNA processing/ribosome biogenesis Dopey_N PF04118.14 EEA25502.1 - 0.014 14.5 1.1 0.43 9.7 0.0 3.0 2 1 1 3 3 3 0 Dopey, N-terminal TIP120 PF08623.10 EEA25502.1 - 0.059 13.1 0.3 13 5.5 0.0 4.2 5 0 0 5 5 5 0 TATA-binding protein interacting (TIP20) Cohesin_HEAT PF12765.7 EEA25502.1 - 0.84 10.0 7.8 41 4.6 0.0 5.8 7 0 0 7 7 7 0 HEAT repeat associated with sister chromatid cohesion Bac_luciferase PF00296.20 EEA25503.1 - 1.4e-58 198.8 0.0 2.2e-58 198.1 0.0 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase FMO-like PF00743.19 EEA25504.1 - 3.2e-15 55.6 0.1 2.1e-12 46.3 0.0 2.7 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EEA25504.1 - 9.7e-15 54.6 0.0 2.8e-14 53.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA25504.1 - 1.1e-10 41.2 0.0 5.8e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA25504.1 - 2.5e-08 33.6 0.0 3.5e-06 26.5 0.0 2.6 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA25504.1 - 2e-06 27.7 0.4 7e-05 22.6 0.4 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EEA25504.1 - 1.6e-05 24.3 0.0 0.0033 16.6 0.0 3.0 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EEA25504.1 - 6e-05 23.1 0.9 0.00085 19.3 0.0 3.2 3 1 0 3 3 3 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 EEA25504.1 - 0.00012 21.5 0.0 0.38 10.1 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EEA25504.1 - 0.0029 16.8 0.1 0.49 9.4 0.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EEA25504.1 - 0.0029 16.9 0.0 0.014 14.6 0.0 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EEA25504.1 - 0.067 12.4 0.4 0.11 11.7 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 EEA25504.1 - 0.08 13.0 0.0 25 4.9 0.0 3.3 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EEA25504.1 - 0.08 12.2 0.0 0.33 10.2 0.1 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EEA25504.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase ADH_zinc_N PF00107.26 EEA25505.1 - 7.3e-07 29.2 0.1 1.9e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA25505.1 - 8.5e-05 22.4 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Zn_clus PF00172.18 EEA25506.1 - 1.6e-07 31.3 14.9 2.4e-07 30.7 14.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA25506.1 - 5.3e-05 22.2 2.4 8.8e-05 21.5 2.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain IL34 PF15036.6 EEA25506.1 - 0.15 12.1 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Interleukin 34 Peptidase_C12 PF01088.21 EEA25507.1 - 4e-70 235.8 0.0 5e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EEA25507.1 - 4.1e-09 36.2 0.1 4.1e-09 36.2 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases Choline_kinase PF01633.20 EEA25508.1 - 1.9e-57 194.3 0.0 4.8e-57 193.0 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EEA25508.1 - 5.4e-17 61.2 0.0 1.2e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EEA25508.1 - 5.5e-05 23.2 0.3 5.5e-05 23.2 0.3 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family MSP1_C PF07462.11 EEA25509.1 - 0.29 9.8 0.1 0.32 9.6 0.1 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Mem_trans PF03547.18 EEA25510.1 - 3.8e-56 190.2 0.0 5e-56 189.7 0.0 1.2 1 0 0 1 1 1 1 Membrane transport protein Mem_trans PF03547.18 EEA25511.1 - 6.2e-41 140.1 0.0 9.2e-41 139.5 0.0 1.2 1 0 0 1 1 1 1 Membrane transport protein Pkinase PF00069.25 EEA25512.1 - 3.9e-54 183.8 0.0 2.3e-51 174.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25512.1 - 2.8e-31 108.8 0.0 1.5e-30 106.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EEA25512.1 - 0.0022 17.1 0.1 0.0037 16.4 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 EEA25512.1 - 0.0083 15.5 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA25512.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pyr_redox_2 PF07992.14 EEA25513.1 - 1.4e-58 198.4 2.6 2.3e-58 197.8 2.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EEA25513.1 - 5.6e-31 107.0 0.6 1.2e-30 105.9 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EEA25513.1 - 8e-15 55.2 0.3 8e-15 55.2 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA25513.1 - 4.5e-11 42.5 3.1 4.3e-10 39.3 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA25513.1 - 1.2e-06 27.9 0.1 2.4e-06 26.9 0.0 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 EEA25513.1 - 0.0085 16.0 0.2 0.0085 16.0 0.2 2.4 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EEA25513.1 - 0.028 13.8 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EEA25513.1 - 0.28 10.2 7.4 0.22 10.5 2.7 2.8 3 1 0 3 3 3 0 Glucose inhibited division protein A DAO PF01266.24 EEA25513.1 - 1.3 8.5 4.9 1.4 8.4 1.7 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase MFS_1 PF07690.16 EEA25514.1 - 2.2e-36 125.5 20.0 2.7e-36 125.2 20.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CorA PF01544.18 EEA25515.1 - 2.9e-08 33.4 7.2 1.1e-07 31.5 7.5 1.8 1 1 1 2 2 2 1 CorA-like Mg2+ transporter protein RHH_4 PF13467.6 EEA25515.1 - 0.065 13.1 2.5 1.8 8.5 0.0 3.4 3 1 0 3 3 3 0 Ribbon-helix-helix domain Ion_trans PF00520.31 EEA25515.1 - 0.068 12.4 2.8 0.1 11.8 2.8 1.2 1 0 0 1 1 1 0 Ion transport protein Glyco_hydro_64 PF16483.5 EEA25517.1 - 9.1e-120 400.3 0.0 1.1e-119 400.1 0.0 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase CDC45 PF02724.14 EEA25518.1 - 0.25 9.6 2.8 0.26 9.6 2.8 1.0 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EEA25518.1 - 0.52 9.7 5.8 0.6 9.5 5.8 1.1 1 0 0 1 1 1 0 SDA1 ADH_zinc_N_2 PF13602.6 EEA25519.1 - 2.6e-12 47.9 0.0 6e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA25519.1 - 7.8e-12 45.0 0.0 2.1e-11 43.7 0.0 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain GreA_GreB PF01272.19 EEA25519.1 - 0.047 13.6 0.1 9.4 6.2 0.0 2.4 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term Acetyltransf_10 PF13673.7 EEA25520.1 - 1e-07 32.0 0.0 2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA25520.1 - 3.8e-07 30.4 0.0 2e-06 28.0 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA25520.1 - 4.5e-05 23.8 0.0 8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA25520.1 - 0.00065 19.6 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EEA25520.1 - 0.0034 17.5 0.0 0.016 15.3 0.0 2.0 2 1 1 3 3 3 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EEA25520.1 - 0.0081 16.2 0.0 0.46 10.6 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain TIM21 PF08294.11 EEA25520.1 - 0.053 13.4 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 TIM21 HXXSHH PF07586.11 EEA25521.1 - 0.007 16.0 2.6 0.012 15.2 2.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1552) DUF4200 PF13863.6 EEA25521.1 - 0.042 14.3 3.6 0.068 13.6 2.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Jnk-SapK_ap_N PF09744.9 EEA25521.1 - 0.27 11.5 8.7 0.32 11.2 7.0 2.1 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF2951 PF11166.8 EEA25521.1 - 0.51 10.6 5.4 5 7.4 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) Spc7 PF08317.11 EEA25521.1 - 0.89 8.4 11.0 0.17 10.7 0.1 2.2 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 EEA25521.1 - 7.3 6.6 7.8 3.7 7.6 3.6 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) tRNA-synt_2b PF00587.25 EEA25522.1 - 4.5e-32 111.5 0.0 7e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EEA25522.1 - 6.4e-05 23.0 0.0 0.00014 21.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain zf-met PF12874.7 EEA25523.1 - 1.5e-16 60.2 31.8 6.3e-06 26.4 1.5 7.2 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EEA25523.1 - 3.6e-15 55.5 34.6 0.026 14.9 0.9 7.3 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EEA25523.1 - 4.2e-15 55.6 31.9 2.1e-07 31.0 2.1 7.1 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EEA25523.1 - 3.6e-12 46.0 31.9 0.026 15.4 0.3 7.8 7 1 1 8 8 8 5 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EEA25523.1 - 2.9e-11 43.6 34.5 0.021 15.1 1.0 7.0 2 2 5 7 7 7 5 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EEA25523.1 - 2.9e-05 23.9 33.8 0.15 12.1 0.3 7.3 7 0 0 7 7 7 3 C2H2-type zinc finger Rad50_zn_hook PF04423.14 EEA25523.1 - 0.0012 18.6 3.3 0.73 9.7 0.0 4.1 3 1 1 4 4 4 1 Rad50 zinc hook motif zf-C2H2_9 PF16293.5 EEA25523.1 - 0.0075 16.1 12.3 1.8 8.5 0.2 5.1 4 2 2 6 6 6 2 C2H2 type zinc-finger (1 copy) zf-C2HC_2 PF13913.6 EEA25523.1 - 0.022 14.6 18.6 0.37 10.8 0.5 5.5 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 EEA25523.1 - 0.083 12.7 19.2 1.4 8.8 2.3 5.1 5 0 0 5 5 5 0 zinc-finger C2H2-type DUF2256 PF10013.9 EEA25523.1 - 0.85 9.8 16.3 2.3 8.4 0.1 5.5 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) AKAP95 PF04988.12 EEA25523.1 - 4.4 7.5 24.2 1 9.6 3.7 4.6 2 2 3 5 5 5 0 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_2 PF13465.6 EEA25523.1 - 6.4 7.4 36.1 0.57 10.7 1.3 7.3 6 1 1 7 7 7 0 Zinc-finger double domain p450 PF00067.22 EEA25525.1 - 4.4e-61 207.0 0.0 5.4e-61 206.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_transf_28 PF03033.20 EEA25527.1 - 1.3e-17 64.1 0.3 1.9e-10 40.9 0.0 2.5 2 0 0 2 2 2 2 Glycosyltransferase family 28 N-terminal domain ATG_C PF09333.11 EEA25527.1 - 1.9e-05 24.9 0.0 5.5e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain UDPGT PF00201.18 EEA25527.1 - 0.00011 21.2 0.0 0.00017 20.5 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EEA25527.1 - 0.045 13.7 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain UIM PF02809.20 EEA25527.1 - 1 9.4 8.4 0.049 13.6 0.8 2.9 3 0 0 3 3 3 0 Ubiquitin interaction motif ADH_N PF08240.12 EEA25528.1 - 3.6e-27 94.4 2.7 8.2e-27 93.2 2.7 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA25528.1 - 4.1e-12 46.2 0.0 7.2e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EEA25528.1 - 2e-05 24.2 3.0 0.039 13.4 1.7 3.2 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus Glyco_hydro_16 PF00722.21 EEA25529.1 - 2.7e-44 150.7 0.7 2.7e-44 150.7 0.7 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Fungal_trans_2 PF11951.8 EEA25530.1 - 7.9e-08 31.5 0.3 1.3e-07 30.8 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_S18 PF01084.20 EEA25530.1 - 0.037 14.2 0.0 0.48 10.7 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S18 Abhydrolase_1 PF00561.20 EEA25531.1 - 8e-12 45.3 0.2 1.2e-11 44.8 0.2 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA25531.1 - 3.1e-09 37.8 7.0 4.4e-09 37.3 7.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA25531.1 - 2.9e-07 30.0 0.1 4.3e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EEA25531.1 - 0.1 11.3 0.0 0.15 10.7 0.0 1.3 1 0 0 1 1 1 0 Ndr family F-box-like PF12937.7 EEA25532.1 - 0.0003 20.6 1.1 0.00072 19.4 1.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA25532.1 - 0.00039 20.2 1.3 0.00088 19.1 1.3 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EEA25532.1 - 0.00066 19.5 1.1 0.001 18.9 0.4 1.6 2 0 0 2 2 2 1 F-box ATP-synt_G PF04718.15 EEA25533.1 - 9.4e-37 125.9 0.3 3.6e-36 124.0 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Senescence PF06911.12 EEA25533.1 - 0.0045 17.3 0.3 0.0063 16.8 0.3 1.4 1 0 0 1 1 1 1 Senescence-associated protein FAM199X PF15814.5 EEA25533.1 - 0.19 10.8 1.7 0.25 10.4 1.7 1.1 1 0 0 1 1 1 0 Protein family FAM199X DEAD PF00270.29 EEA25534.1 - 1.3e-25 90.2 0.3 1.2e-24 87.0 0.3 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA25534.1 - 4.3e-24 85.0 0.1 2.4e-23 82.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA25534.1 - 1.6e-06 28.2 0.0 1.6e-05 25.0 0.0 2.4 1 1 2 3 3 3 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EEA25534.1 - 0.017 14.0 0.0 0.21 10.3 0.1 2.3 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Methyltransf_16 PF10294.9 EEA25536.1 - 1.1e-22 80.6 0.0 2.1e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EEA25536.1 - 1.6e-05 24.8 0.0 3.7e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA25536.1 - 0.12 13.1 0.0 0.31 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PHBC_N PF12551.8 EEA25536.1 - 3.3 7.5 5.3 1.6 8.5 0.1 2.8 3 0 0 3 3 3 0 Poly-beta-hydroxybutyrate polymerase N terminal VPS28 PF03997.12 EEA25537.1 - 3.9e-74 248.4 0.1 4.6e-74 248.2 0.1 1.0 1 0 0 1 1 1 1 VPS28 protein Noc2 PF03715.13 EEA25538.1 - 1.3e-128 428.5 0.2 3.5e-128 427.0 0.0 1.8 2 0 0 2 2 2 1 Noc2p family Nop14 PF04147.12 EEA25538.1 - 0.056 11.7 0.0 0.056 11.7 0.0 3.4 2 1 1 3 3 3 0 Nop14-like family TrkH PF02386.16 EEA25539.1 - 1.2e-93 314.2 12.0 4.1e-92 309.2 4.1 2.0 2 0 0 2 2 2 2 Cation transport protein Glyco_hydro_18 PF00704.28 EEA25540.1 - 2e-24 86.9 0.3 3.5e-24 86.1 0.3 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 ABC_tran PF00005.27 EEA25541.1 - 6.2e-44 149.8 1.3 2.2e-21 76.8 0.0 3.5 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EEA25541.1 - 1e-13 51.8 9.1 0.00062 19.7 0.0 4.3 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA25541.1 - 4.3e-13 49.2 0.4 0.0012 18.3 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 EEA25541.1 - 4e-09 36.4 2.0 1.5e-08 34.5 2.0 2.0 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 EEA25541.1 - 5.7e-08 32.8 0.2 0.0041 17.2 0.0 3.3 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EEA25541.1 - 9.4e-07 28.5 0.9 0.0026 17.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EEA25541.1 - 3.9e-06 26.8 0.2 0.0043 16.8 0.0 2.5 2 1 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 EEA25541.1 - 2e-05 25.0 6.4 0.0059 17.0 0.1 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EEA25541.1 - 7.3e-05 23.3 1.4 0.21 12.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EEA25541.1 - 0.00013 22.1 0.1 0.15 12.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EEA25541.1 - 0.00016 21.6 0.1 0.31 11.0 0.0 2.8 2 1 0 2 2 2 2 NACHT domain AAA_28 PF13521.6 EEA25541.1 - 0.00028 21.2 0.8 0.12 12.6 0.1 2.8 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EEA25541.1 - 0.0003 20.7 0.7 0.59 10.0 0.1 3.1 3 0 0 3 3 2 2 RsgA GTPase AAA_30 PF13604.6 EEA25541.1 - 0.00032 20.5 0.3 0.73 9.5 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EEA25541.1 - 0.00038 21.0 20.4 0.093 13.2 11.5 3.3 3 1 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 EEA25541.1 - 0.0007 20.0 0.1 2.7 8.4 0.1 2.9 3 0 0 3 3 2 2 RNA helicase AAA_14 PF13173.6 EEA25541.1 - 0.00076 19.5 0.3 3.7 7.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 EEA25541.1 - 0.00091 19.2 0.6 0.15 11.9 0.1 2.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA PF00004.29 EEA25541.1 - 0.0034 17.8 1.0 1.4 9.4 0.1 3.2 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA25541.1 - 0.0064 16.8 6.1 1.1 9.5 0.1 3.5 3 2 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EEA25541.1 - 0.0065 15.7 0.8 3.5 6.7 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain NTPase_1 PF03266.15 EEA25541.1 - 0.0095 15.9 0.3 9.7 6.1 0.0 3.9 4 0 0 4 4 4 0 NTPase Thymidylate_kin PF02223.17 EEA25541.1 - 0.01 15.5 0.4 7.6 6.2 0.0 3.0 3 0 0 3 3 3 0 Thymidylate kinase Dynamin_N PF00350.23 EEA25541.1 - 0.012 15.7 3.0 3.5 7.6 1.9 3.0 2 1 0 2 2 2 0 Dynamin family ADPrib_exo_Tox PF03496.14 EEA25541.1 - 0.016 14.5 0.9 0.081 12.3 0.7 2.2 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme Rad17 PF03215.15 EEA25541.1 - 0.025 14.5 0.0 2.7 7.9 0.0 2.8 3 0 0 3 3 3 0 Rad17 P-loop domain Zeta_toxin PF06414.12 EEA25541.1 - 0.029 13.6 0.5 2.4 7.4 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_5 PF07728.14 EEA25541.1 - 0.03 14.3 2.4 1.2 9.1 0.0 3.5 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 EEA25541.1 - 0.031 14.0 0.1 12 5.5 0.1 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 EEA25541.1 - 0.037 13.0 7.1 0.44 9.5 0.3 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 EEA25541.1 - 0.046 14.1 5.8 2.4 8.6 0.0 3.8 2 1 1 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EEA25541.1 - 0.047 13.0 2.3 0.44 9.8 0.1 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_27 PF13514.6 EEA25541.1 - 0.052 13.1 4.2 0.23 11.0 0.2 2.7 3 1 0 3 3 2 0 AAA domain AAA_7 PF12775.7 EEA25541.1 - 0.054 13.0 0.2 0.86 9.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region MobB PF03205.14 EEA25541.1 - 0.056 13.3 0.6 11 5.9 0.6 2.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PRK PF00485.18 EEA25541.1 - 0.093 12.5 0.0 13 5.4 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.20 EEA25541.1 - 0.12 11.5 1.3 0.88 8.7 0.2 2.2 2 0 0 2 2 2 0 G-protein alpha subunit NifQ PF04891.12 EEA25541.1 - 0.14 12.5 1.4 0.71 10.2 0.0 2.4 2 1 0 2 2 2 0 NifQ SRPRB PF09439.10 EEA25541.1 - 0.22 10.9 3.4 3.8 6.9 0.1 3.1 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit DUF87 PF01935.17 EEA25541.1 - 5.4 7.0 18.9 0.69 10.0 0.1 3.7 3 1 1 4 4 3 0 Helicase HerA, central domain MoaC PF01967.21 EEA25542.1 - 8.6e-47 158.6 0.4 1.6e-46 157.7 0.4 1.5 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 EEA25542.1 - 4.6e-37 126.8 0.2 2.1e-36 124.7 0.0 2.1 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EEA25542.1 - 8.2e-27 94.6 0.1 1.6e-26 93.6 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EEA25542.1 - 0.00028 21.2 0.0 0.00069 19.9 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain PRIMA1 PF16101.5 EEA25542.1 - 3 7.9 12.4 2.3 8.3 9.0 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 BTB PF00651.31 EEA25543.1 - 2e-16 60.2 0.0 3.6e-15 56.2 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain FYVE PF01363.21 EEA25543.1 - 0.5 10.5 3.4 2 8.6 3.4 2.1 1 1 0 1 1 1 0 FYVE zinc finger Acetyltransf_3 PF13302.7 EEA25544.1 - 1e-16 61.8 0.0 1.4e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA25544.1 - 0.0011 19.2 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EEA25544.1 - 0.0076 16.4 0.1 0.013 15.7 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain bZIP_1 PF00170.21 EEA25545.1 - 1.9e-09 37.5 12.8 1.9e-09 37.5 12.8 1.9 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EEA25545.1 - 4.8e-05 23.4 12.0 4.8e-05 23.4 12.0 2.8 3 0 0 3 3 3 1 Basic region leucine zipper TFIIA PF03153.13 EEA25545.1 - 0.92 9.4 26.6 0.18 11.8 22.9 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDE_1 PF03184.19 EEA25546.1 - 1.1e-33 116.3 0.0 2.2e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA25546.1 - 3.5e-10 39.8 0.5 1.7e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA25546.1 - 2e-06 27.4 0.0 5.3e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-CCHC_2 PF13696.6 EEA25546.1 - 0.08 12.8 1.5 0.14 12.0 1.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EEA25546.1 - 0.34 11.1 2.1 0.62 10.3 2.1 1.4 1 0 0 1 1 1 0 Zinc knuckle adh_short PF00106.25 EEA25547.1 - 4.3e-40 137.3 0.5 6.2e-40 136.8 0.1 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25547.1 - 1e-27 97.2 0.0 2.6e-27 95.9 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA25547.1 - 3.2e-07 30.5 0.1 4.7e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA25547.1 - 2.1e-05 24.5 0.0 3.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA25547.1 - 3.6e-05 23.5 0.0 7.1e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family Vma12 PF11712.8 EEA25547.1 - 0.03 14.4 0.3 0.049 13.7 0.3 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Epimerase PF01370.21 EEA25547.1 - 0.032 13.7 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EEA25547.1 - 0.091 12.1 0.0 3.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EEA25547.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Zn_clus PF00172.18 EEA25548.1 - 0.13 12.4 15.3 0.26 11.4 15.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Lactamase_B_4 PF13691.6 EEA25549.1 - 2.6e-21 75.1 0.0 7.4e-21 73.6 0.0 1.9 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EEA25549.1 - 3e-12 46.5 0.1 6.2e-05 22.6 0.1 2.8 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EEA25549.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily WD40 PF00400.32 EEA25550.1 - 2.1e-50 167.6 16.2 3.3e-09 37.2 0.6 8.4 8 1 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA25550.1 - 1.9e-11 44.1 0.1 0.0002 21.6 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA25550.1 - 7.5e-08 31.5 0.9 0.00021 20.1 0.0 3.9 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EEA25550.1 - 0.0047 15.7 0.0 3.5 6.3 0.0 2.9 2 1 1 3 3 3 2 Nup133 N terminal like Ge1_WD40 PF16529.5 EEA25550.1 - 0.025 13.6 0.2 3.2 6.6 0.0 3.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein His_Phos_2 PF00328.22 EEA25551.1 - 1.3e-10 41.2 0.0 1.3e-09 37.9 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.22 EEA25552.1 - 9.1e-14 51.6 0.5 3.2e-12 46.5 0.5 2.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) 2OG-FeII_Oxy_3 PF13640.6 EEA25553.1 - 6.7e-11 42.9 0.0 1.1e-10 42.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3201 PF11447.8 EEA25553.1 - 0.0021 17.6 0.1 0.0041 16.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3201) DUF3328 PF11807.8 EEA25555.1 - 2.5e-39 135.3 0.0 3.8e-39 134.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EEA25556.1 - 0.056 13.2 3.4 0.15 11.8 3.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) EamA PF00892.20 EEA25557.1 - 8.9e-06 25.9 5.0 1.3e-05 25.4 5.0 1.4 1 0 0 1 1 1 1 EamA-like transporter family Wzy_C PF04932.15 EEA25557.1 - 0.027 14.1 0.2 0.05 13.2 0.2 1.5 1 0 0 1 1 1 0 O-Antigen ligase DUF2254 PF10011.9 EEA25557.1 - 0.18 10.6 0.8 0.28 9.9 0.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF3328 PF11807.8 EEA25558.1 - 1.9e-22 80.2 3.9 8.1e-22 78.1 3.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF2976 PF11190.8 EEA25558.1 - 0.0072 16.1 0.1 5.5 6.9 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2976) Vpu PF00558.19 EEA25558.1 - 0.075 12.8 0.5 0.21 11.4 0.5 1.7 1 0 0 1 1 1 0 Vpu protein Abhydrolase_3 PF07859.13 EEA25559.1 - 1.1e-46 159.3 0.1 2.3e-46 158.3 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA25559.1 - 2.3e-12 46.6 0.3 2.8e-11 43.0 0.3 1.9 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EEA25559.1 - 0.012 14.5 0.0 0.016 14.0 0.0 1.1 1 0 0 1 1 1 0 Steryl acetyl hydrolase DUF2974 PF11187.8 EEA25559.1 - 0.018 14.6 0.1 0.028 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_2 PF02230.16 EEA25559.1 - 0.13 12.1 0.0 0.41 10.4 0.0 1.8 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Gtr1_RagA PF04670.12 EEA25560.1 - 2.3e-68 230.0 0.1 3.9e-68 229.3 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EEA25560.1 - 7.2e-05 22.3 0.0 0.00015 21.2 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EEA25560.1 - 0.021 14.3 0.1 0.047 13.1 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EEA25560.1 - 0.036 14.2 0.0 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA25560.1 - 0.071 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Roc PF08477.13 EEA25560.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EEA25560.1 - 0.16 12.3 0.0 0.41 11.0 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain Cyt-b5 PF00173.28 EEA25561.1 - 4.2e-07 30.0 0.0 8.6e-07 29.0 0.0 1.6 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ribosomal_S25 PF03297.15 EEA25562.1 - 3.6e-39 133.0 3.8 3.9e-39 132.9 3.8 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_DeoR PF08220.12 EEA25562.1 - 0.00099 18.8 0.1 0.0014 18.4 0.1 1.2 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_24 PF13412.6 EEA25562.1 - 0.012 15.1 0.1 0.018 14.6 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 EEA25562.1 - 0.015 15.1 0.1 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.12 EEA25562.1 - 0.017 15.1 0.1 0.023 14.6 0.1 1.3 1 0 0 1 1 1 0 HTH domain Rrf2 PF02082.20 EEA25562.1 - 0.029 14.7 0.1 0.041 14.2 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator ketoacyl-synt PF00109.26 EEA25563.1 - 2.4e-73 246.9 0.0 9e-73 245.0 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EEA25563.1 - 1.7e-62 211.3 2.8 2.5e-59 200.9 0.1 3.1 2 1 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EEA25563.1 - 5.6e-49 167.4 0.0 1.2e-48 166.3 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA25563.1 - 2.6e-35 121.0 2.1 6.2e-35 119.8 2.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EEA25563.1 - 2.2e-21 77.0 0.0 7.9e-21 75.2 0.0 2.0 1 0 0 1 1 1 1 Thioesterase domain PS-DH PF14765.6 EEA25563.1 - 1.1e-11 44.6 0.1 2e-11 43.7 0.1 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 EEA25563.1 - 1.4e-10 41.4 0.4 4.9e-10 39.6 0.4 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EEA25563.1 - 1.1e-07 32.3 0.2 5.5e-07 30.0 0.0 2.4 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EEA25563.1 - 0.0012 18.3 0.0 0.0029 17.0 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain DUF2974 PF11187.8 EEA25563.1 - 0.13 11.8 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Glu_dehyd_C PF16912.5 EEA25563.1 - 0.19 11.2 1.3 12 5.3 0.1 2.8 3 0 0 3 3 3 0 Glucose dehydrogenase C-terminus Bac_DNA_binding PF00216.21 EEA25563.1 - 0.42 10.8 1.6 3.5 7.9 0.0 3.0 3 0 0 3 3 3 0 Bacterial DNA-binding protein ABC_membrane PF00664.23 EEA25564.1 - 8.2e-91 304.4 21.8 1.5e-45 156.0 6.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA25564.1 - 6.1e-71 237.3 0.7 3.6e-35 121.5 0.1 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EEA25564.1 - 2.2e-13 50.2 6.1 0.0002 20.8 1.0 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EEA25564.1 - 1.2e-09 38.2 0.2 0.0006 19.7 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EEA25564.1 - 2.8e-09 36.6 0.1 0.0024 17.6 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA25564.1 - 2.3e-08 34.6 1.1 0.0018 18.7 0.1 2.9 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA25564.1 - 6.8e-08 32.9 0.9 0.008 16.5 0.0 3.6 2 2 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 EEA25564.1 - 2.1e-07 30.1 1.4 0.018 13.9 0.1 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_15 PF13175.6 EEA25564.1 - 3e-07 30.5 0.0 0.0088 15.8 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain G-alpha PF00503.20 EEA25564.1 - 6.5e-06 25.5 0.1 0.032 13.4 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_30 PF13604.6 EEA25564.1 - 1e-05 25.3 5.3 0.063 13.0 0.9 4.1 2 2 0 2 2 2 2 AAA domain DUF87 PF01935.17 EEA25564.1 - 1.4e-05 25.3 0.3 0.017 15.2 0.0 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 EEA25564.1 - 2.6e-05 24.3 0.1 0.057 13.5 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EEA25564.1 - 3.3e-05 23.3 0.1 0.012 14.9 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 EEA25564.1 - 8e-05 22.4 0.0 0.3 10.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EEA25564.1 - 8.6e-05 22.5 0.5 0.61 9.8 0.0 3.3 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system APS_kinase PF01583.20 EEA25564.1 - 0.00012 22.0 0.1 0.065 13.1 0.0 2.7 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_33 PF13671.6 EEA25564.1 - 0.00021 21.5 0.2 0.72 10.0 0.0 3.0 2 1 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 EEA25564.1 - 0.00021 21.4 3.3 1.2 9.4 0.2 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit DUF815 PF05673.13 EEA25564.1 - 0.00025 20.3 0.0 0.14 11.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 EEA25564.1 - 0.00028 20.5 0.0 0.59 9.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EEA25564.1 - 0.00056 19.3 0.1 0.83 9.0 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_18 PF13238.6 EEA25564.1 - 0.00068 20.2 0.0 0.7 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EEA25564.1 - 0.00079 20.0 0.2 1.2 9.6 0.0 2.7 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 EEA25564.1 - 0.0015 18.3 0.3 17 5.1 0.0 3.9 4 0 0 4 4 4 0 IstB-like ATP binding protein Ploopntkinase3 PF18751.1 EEA25564.1 - 0.0015 18.5 0.1 1.2 9.0 0.1 2.5 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 AAA_5 PF07728.14 EEA25564.1 - 0.0018 18.2 1.0 2.4 8.2 0.0 4.3 4 1 1 5 5 4 1 AAA domain (dynein-related subfamily) IIGP PF05049.13 EEA25564.1 - 0.0023 17.0 0.2 0.12 11.4 0.0 2.4 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) PRK PF00485.18 EEA25564.1 - 0.0053 16.5 0.1 2.2 8.0 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 EEA25564.1 - 0.0094 16.2 0.1 5.5 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA25564.1 - 0.011 15.3 0.0 3.8 7.0 0.0 3.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EEA25564.1 - 0.017 15.2 1.5 0.8 9.7 0.2 2.6 2 0 0 2 2 2 0 Dynamin family TniB PF05621.11 EEA25564.1 - 0.03 13.7 0.2 45 3.4 0.0 4.4 4 1 1 5 5 5 0 Bacterial TniB protein SRP54 PF00448.22 EEA25564.1 - 0.034 13.8 0.0 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Septin PF00735.18 EEA25564.1 - 0.036 13.3 0.5 0.92 8.7 0.0 2.5 3 0 0 3 3 2 0 Septin KAP_NTPase PF07693.14 EEA25564.1 - 0.044 13.0 0.0 5.5 6.1 0.0 2.4 2 0 0 2 2 2 0 KAP family P-loop domain Pox_A32 PF04665.12 EEA25564.1 - 0.048 13.1 0.1 3.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein Mg_chelatase PF01078.21 EEA25564.1 - 0.049 13.0 0.0 3.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA25564.1 - 0.056 13.8 0.0 9.6 6.6 0.0 2.8 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 EEA25564.1 - 0.058 12.6 0.0 11 5.1 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 EEA25564.1 - 0.063 13.2 0.1 6 6.7 0.0 2.6 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.17 EEA25564.1 - 0.064 13.0 0.2 11 5.7 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein TrwB_AAD_bind PF10412.9 EEA25564.1 - 0.076 11.9 0.1 0.84 8.5 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain FeoB_N PF02421.18 EEA25564.1 - 0.12 11.9 0.0 5.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Roc PF08477.13 EEA25564.1 - 0.14 12.4 0.1 33 4.7 0.0 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 EEA25564.1 - 0.15 12.0 0.1 5.4 6.9 0.0 2.7 3 0 0 3 3 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 EEA25564.1 - 0.26 11.2 1.5 29 4.5 0.0 3.6 4 0 0 4 4 3 0 NTPase Halogen_Hydrol PF10112.9 EEA25564.1 - 1.7 8.6 3.4 4.9 7.1 0.1 2.7 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein UDPGT PF00201.18 EEA25565.1 - 2.4e-25 89.3 0.0 3.5e-25 88.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EEA25565.1 - 4.3e-07 30.1 0.0 7.6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.6 EEA25565.1 - 0.0025 18.2 0.0 0.0047 17.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 RTA1 PF04479.13 EEA25567.1 - 1.5e-59 201.1 13.4 2.3e-59 200.5 13.4 1.2 1 0 0 1 1 1 1 RTA1 like protein NrsF PF06532.11 EEA25567.1 - 0.2 11.4 12.0 0.12 12.1 2.2 2.5 3 0 0 3 3 3 0 Negative regulator of sigma F DUF4134 PF13572.6 EEA25567.1 - 0.22 11.9 0.2 0.22 11.9 0.2 3.4 3 2 2 5 5 5 0 Domain of unknown function (DUF4134) DUF5373 PF17343.2 EEA25567.1 - 2.4 7.9 8.5 3.8 7.3 2.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5373) DUF2809 PF10990.8 EEA25567.1 - 2.8 8.7 9.8 12 6.7 0.1 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF2809) DUF996 PF06195.13 EEA25567.1 - 2.9 8.2 21.5 0.041 14.2 7.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF996) COX7B PF05392.11 EEA25567.1 - 7.5 6.3 5.8 6.9 6.4 0.0 3.4 3 1 1 4 4 4 0 Cytochrome C oxidase chain VIIB ketoacyl-synt PF00109.26 EEA25568.1 - 2.6e-77 259.8 0.3 4.6e-77 259.0 0.3 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA25568.1 - 8.9e-63 211.4 0.1 3e-62 209.7 0.1 2.0 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 EEA25568.1 - 8.8e-52 176.6 0.1 2.4e-51 175.2 0.1 1.8 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EEA25568.1 - 9.5e-52 176.1 0.0 2.1e-51 174.9 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EEA25568.1 - 7.8e-34 116.2 0.3 1.9e-33 115.0 0.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EEA25568.1 - 1.2e-19 70.8 0.0 2.9e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EEA25568.1 - 9.3e-18 64.5 0.0 3.1e-17 62.8 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EEA25568.1 - 2e-16 60.0 1.4 2.7e-15 56.3 0.0 2.9 3 0 0 3 3 3 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EEA25568.1 - 2.8e-14 54.3 0.0 9.4e-14 52.6 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EEA25568.1 - 1.3e-07 31.4 0.4 4.2e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EEA25568.1 - 2.9e-07 30.7 0.5 9.8e-07 29.0 0.0 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site ADH_N PF08240.12 EEA25568.1 - 2.4e-06 27.4 0.3 6.4e-06 26.0 0.3 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EEA25568.1 - 0.00034 20.0 0.1 0.00075 18.9 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ELFV_dehydrog PF00208.21 EEA25568.1 - 0.0016 18.2 0.7 4.4 6.9 0.1 3.2 3 0 0 3 3 3 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 EEA25568.1 - 0.014 14.8 0.2 5.1 6.4 0.1 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.21 EEA25568.1 - 0.04 13.3 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 ThiF family PALP PF00291.25 EEA25568.1 - 1.9 7.8 5.0 0.78 9.1 0.3 2.5 3 0 0 3 3 3 0 Pyridoxal-phosphate dependent enzyme ANAPC4_WD40 PF12894.7 EEA25569.1 - 1.2e-06 28.7 2.0 0.23 11.8 0.0 4.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA25569.1 - 0.0036 18.1 4.7 5.4 8.1 0.1 5.6 5 1 0 5 5 5 1 WD domain, G-beta repeat PD40 PF07676.12 EEA25569.1 - 0.098 12.6 1.8 0.39 10.7 0.2 2.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat HNH_4 PF13395.6 EEA25569.1 - 0.13 12.2 0.2 6.3 6.8 0.0 2.5 2 0 0 2 2 2 0 HNH endonuclease IKI3 PF04762.12 EEA25569.1 - 0.14 10.1 0.1 3.1 5.7 0.0 2.4 3 0 0 3 3 3 0 IKI3 family Dus PF01207.17 EEA25570.1 - 4.6e-59 200.0 0.0 1.3e-58 198.5 0.0 1.7 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) DUF1484 PF07363.11 EEA25570.1 - 0.047 14.7 0.8 2.4 9.2 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1484) DHO_dh PF01180.21 EEA25570.1 - 0.072 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Imm39 PF15568.6 EEA25570.1 - 0.092 12.9 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 39 LysM PF01476.20 EEA25571.1 - 9.9e-11 41.5 0.0 0.0017 18.4 0.0 3.3 3 0 0 3 3 3 3 LysM domain Aldo_ket_red PF00248.21 EEA25572.1 - 6.5e-55 186.4 0.0 7.9e-55 186.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ponericin PF07442.11 EEA25572.1 - 1.1 9.4 3.0 11 6.1 0.2 2.4 2 0 0 2 2 2 0 Ponericin Inositol_P PF00459.25 EEA25573.1 - 1.4e-58 198.6 0.0 1.8e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family Amino_oxidase PF01593.24 EEA25575.1 - 8.9e-18 64.8 0.0 1.1e-16 61.2 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EEA25575.1 - 3e-14 53.0 0.1 6.5e-14 51.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA25575.1 - 1.5e-06 27.2 0.6 0.014 14.2 0.2 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 EEA25575.1 - 2.3e-06 27.1 0.1 0.00059 19.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA25575.1 - 1.3e-05 25.0 0.8 3.4e-05 23.6 0.4 1.9 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EEA25575.1 - 6e-05 23.1 0.1 0.014 15.3 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EEA25575.1 - 0.0041 17.6 0.1 0.018 15.6 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA25575.1 - 0.0098 15.0 0.2 0.025 13.7 0.2 1.6 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EEA25575.1 - 0.015 14.7 0.1 0.028 13.8 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA25575.1 - 0.023 13.9 0.2 0.16 11.2 0.0 2.2 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA25575.1 - 0.095 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EEA25575.1 - 0.098 11.7 0.2 0.17 10.9 0.2 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A ApbA PF02558.16 EEA25575.1 - 0.14 11.8 0.1 2.6 7.7 0.0 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 EEA25575.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pox_E6 PF04656.12 EEA25575.1 - 0.18 10.2 0.0 0.25 9.8 0.0 1.1 1 0 0 1 1 1 0 Pox virus E6 protein DUF1365 PF07103.11 EEA25576.1 - 7.7e-43 146.9 0.1 1.1e-42 146.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) DUF4688 PF15752.5 EEA25576.1 - 0.077 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4688) DSBA PF01323.20 EEA25577.1 - 8.8e-20 71.3 0.0 1e-19 71.1 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain DUF899 PF05988.12 EEA25577.1 - 0.16 11.4 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) Hexokinase_2 PF03727.16 EEA25578.1 - 6.7e-65 218.9 0.0 5.9e-63 212.5 0.0 2.1 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EEA25578.1 - 3.7e-61 206.5 0.0 6.3e-61 205.7 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Zn_clus PF00172.18 EEA25579.1 - 1.2e-06 28.5 9.3 2.2e-06 27.7 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glucosamine_iso PF01182.20 EEA25580.1 - 2.7e-20 73.2 0.0 5e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sugar-bind PF04198.13 EEA25580.1 - 0.014 14.6 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain AA_permease_2 PF13520.6 EEA25581.1 - 4e-60 203.8 57.2 4.8e-60 203.6 57.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA25581.1 - 6.2e-23 81.1 46.6 7.9e-23 80.8 46.6 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1689 PF07954.11 EEA25583.1 - 0.055 13.9 0.1 0.091 13.2 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1689) EMP24_GP25L PF01105.24 EEA25583.1 - 0.069 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD LCM PF04072.14 EEA25584.1 - 6.5e-22 78.4 0.0 1.7e-20 73.8 0.0 2.5 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Alpha_GJ PF03229.13 EEA25584.1 - 0.13 12.8 0.3 0.13 12.8 0.3 1.7 2 0 0 2 2 2 0 Alphavirus glycoprotein J zf-RING_2 PF13639.6 EEA25585.1 - 1.3e-07 31.9 8.6 2.2e-07 31.1 8.6 1.4 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 EEA25585.1 - 6.6e-05 23.0 6.0 0.00014 21.9 6.0 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 EEA25585.1 - 0.00011 22.4 7.9 0.00024 21.3 7.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EEA25585.1 - 0.0002 21.3 2.4 0.00043 20.3 2.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EEA25585.1 - 0.00034 20.4 9.2 0.0006 19.6 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA25585.1 - 0.01 15.7 8.0 0.019 14.8 8.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2884 PF11101.8 EEA25585.1 - 0.14 11.7 3.6 13 5.2 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2884) RINGv PF12906.7 EEA25585.1 - 0.17 12.1 7.3 0.35 11.0 7.3 1.6 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 EEA25585.1 - 0.32 10.7 6.1 0.61 9.8 6.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 EEA25585.1 - 0.32 10.9 5.7 0.68 9.9 5.7 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 EEA25585.1 - 0.4 11.0 8.0 0.7 10.3 8.0 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 EEA25585.1 - 0.4 10.5 6.7 5.5 6.9 1.0 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EEA25585.1 - 0.7 9.7 2.9 1.3 8.8 2.9 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EEA25585.1 - 1.7 8.6 5.8 3.2 7.7 5.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 EEA25585.1 - 2 8.4 7.1 3.4 7.6 7.1 1.4 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EEA25585.1 - 5 7.1 6.1 11 6.0 6.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DEAD_2 PF06733.15 EEA25586.1 - 6.4e-55 185.5 1.1 1.1e-54 184.7 0.3 1.8 2 0 0 2 2 2 1 DEAD_2 HBB PF06777.11 EEA25586.1 - 1.4e-45 155.4 3.1 6.3e-41 140.2 1.0 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EEA25586.1 - 6e-43 147.0 0.0 1.6e-42 145.6 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 EEA25586.1 - 8.6e-07 29.1 0.0 4.7e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EEA25586.1 - 0.003 17.4 0.4 0.0092 15.8 0.4 1.8 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 EEA25586.1 - 0.005 16.6 0.0 0.54 10.0 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.23 EEA25586.1 - 0.017 13.8 0.2 0.39 9.4 0.2 2.2 1 1 0 1 1 1 0 SNF2 family N-terminal domain DUF2075 PF09848.9 EEA25586.1 - 0.027 13.7 0.4 1.1 8.4 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EEA25586.1 - 0.037 14.4 0.0 0.11 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA25586.1 - 0.053 13.8 0.8 8.5 6.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF2492 PF10678.9 EEA25586.1 - 0.11 12.8 0.1 0.39 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2492) DUF4953 PF16313.5 EEA25586.1 - 0.13 11.5 0.3 0.61 9.2 0.0 1.9 2 0 0 2 2 2 0 Met-zincin RNA_pol_Rpb1_5 PF04998.17 EEA25587.1 - 2.9e-80 269.6 1.3 6.6e-80 268.4 1.3 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EEA25587.1 - 2.5e-63 213.3 0.1 4.9e-63 212.3 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EEA25587.1 - 1.2e-35 122.8 0.0 5.7e-35 120.6 0.0 2.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EEA25587.1 - 1e-29 103.9 0.4 1.3e-27 97.0 0.1 3.3 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EEA25587.1 - 4.6e-15 55.5 2.5 5.6e-15 55.2 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Nop14 PF04147.12 EEA25587.1 - 0.016 13.4 23.1 0.028 12.7 23.1 1.2 1 0 0 1 1 1 0 Nop14-like family Lipid_DES PF08557.10 EEA25587.1 - 0.064 12.8 0.2 0.24 10.9 0.0 2.1 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) SDA1 PF05285.12 EEA25587.1 - 1.5 8.2 31.8 2.9 7.2 31.8 1.4 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EEA25587.1 - 5.6 6.2 26.6 10 5.3 26.6 1.3 1 0 0 1 1 1 0 BUD22 PRP3 PF08572.10 EEA25588.1 - 2.8e-72 243.1 7.2 5.4e-72 242.2 7.2 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EEA25588.1 - 2.2e-47 160.8 0.1 2.2e-47 160.8 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Gar1 PF04410.14 EEA25589.1 - 1.9e-47 160.9 0.3 4.8e-47 159.6 0.3 1.7 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region SR-25 PF10500.9 EEA25589.1 - 2.7 7.5 11.9 14 5.2 6.4 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 EEA25589.1 - 5 6.8 18.4 0.63 9.7 10.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Glyco_transf_22 PF03901.17 EEA25590.1 - 1.4e-83 281.4 10.0 1.7e-83 281.2 10.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family 2-Hacid_dh_C PF02826.19 EEA25591.1 - 3.3e-41 140.6 0.1 8e-41 139.3 0.1 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA25591.1 - 3.3e-23 81.8 0.0 8.7e-23 80.5 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 EEA25591.1 - 0.00021 21.8 0.2 0.059 13.9 0.0 2.3 2 0 0 2 2 2 2 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 EEA25591.1 - 0.00022 21.3 1.3 0.00047 20.2 1.3 1.5 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain F420_oxidored PF03807.17 EEA25591.1 - 0.0004 20.9 0.7 0.0021 18.6 0.1 2.2 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 EEA25591.1 - 0.0098 15.5 0.1 0.017 14.7 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 EEA25591.1 - 0.094 12.0 3.5 0.28 10.4 3.4 1.7 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EEA25591.1 - 0.12 12.6 2.6 3 8.1 0.5 2.8 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain His_Phos_1 PF00300.22 EEA25592.1 - 6.7e-19 68.3 0.0 1.7e-18 67.0 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Transp_inhibit PF18791.1 EEA25592.1 - 0.11 12.0 0.1 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 Transport inhibitor response 1 protein domain Ndc1_Nup PF09531.10 EEA25593.1 - 0.038 12.7 2.2 0.046 12.4 2.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ndc1_Nup PF09531.10 EEA25594.1 - 0.038 12.7 2.2 0.046 12.4 2.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Rav1p_C PF12234.8 EEA25595.1 - 6.1e-281 933.4 0.0 8.7e-281 933.0 0.0 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal WD40 PF00400.32 EEA25595.1 - 5e-05 24.0 2.4 2.1 9.4 0.0 5.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA25595.1 - 0.0056 16.9 0.2 26 5.2 0.0 3.9 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA25595.1 - 0.026 13.2 0.2 0.072 11.7 0.2 1.7 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Sfi1 PF08457.10 EEA25596.1 - 4.1e-187 623.2 87.4 4.1e-187 623.2 76.9 2.2 1 1 1 2 2 2 2 Sfi1 spindle body protein MAGI_u1 PF16663.5 EEA25596.1 - 0.97 9.6 3.1 8 6.6 0.2 2.6 2 0 0 2 2 2 0 Unstructured region on MAGI NDUF_B7 PF05676.13 EEA25597.1 - 0.0045 16.7 2.8 0.86 9.4 0.5 2.1 1 1 1 2 2 2 2 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CX9C PF16860.5 EEA25597.1 - 0.0046 16.9 3.1 0.0079 16.2 3.1 1.5 1 1 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EEA25597.1 - 0.19 11.9 4.5 1.1 9.5 3.4 2.2 1 1 1 2 2 2 0 CHCH domain tRNA-synt_1 PF00133.22 EEA25598.1 - 8.6e-224 744.3 0.0 1.2e-223 743.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EEA25598.1 - 7.1e-26 91.0 0.0 1.7e-25 89.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EEA25598.1 - 5e-14 51.9 0.0 4.1e-06 25.8 0.0 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EEA25598.1 - 0.078 12.3 0.0 0.28 10.5 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain TAN PF11640.8 EEA25598.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair Uso1_p115_head PF04869.14 EEA25599.1 - 4.3e-107 357.8 0.0 9.7e-107 356.7 0.0 1.6 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EEA25599.1 - 1.8e-16 60.7 33.1 1.8e-16 60.7 33.1 3.5 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region Myosin_tail_1 PF01576.19 EEA25599.1 - 6.4e-06 24.3 51.1 6.4e-06 24.3 51.1 2.0 1 1 1 2 2 2 1 Myosin tail PKK PF12474.8 EEA25599.1 - 0.005 17.0 29.4 0.005 17.0 29.4 4.4 1 1 2 3 3 3 2 Polo kinase kinase Phage_Mu_Gam PF07352.12 EEA25599.1 - 0.015 15.2 2.5 0.015 15.2 2.5 4.6 2 1 2 5 5 5 0 Bacteriophage Mu Gam like protein DUF3584 PF12128.8 EEA25599.1 - 0.086 10.3 60.3 0.12 9.8 60.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GARP PF16731.5 EEA25599.1 - 2 8.0 32.8 0.093 12.4 16.4 3.2 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma XRN_M PF17846.1 EEA25600.1 - 5.1e-145 483.8 2.0 1.3e-143 479.2 0.0 2.5 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 EEA25600.1 - 2.6e-100 334.9 1.7 1.2e-99 332.6 0.0 2.1 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 EEA25600.1 - 0.002 18.1 1.8 0.0035 17.4 1.8 1.4 1 0 0 1 1 1 1 Zinc knuckle UDPG_MGDP_dh_N PF03721.14 EEA25600.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain zf-CCHC_2 PF13696.6 EEA25600.1 - 0.16 11.8 1.6 0.33 10.8 1.6 1.5 1 0 0 1 1 1 0 Zinc knuckle EPSP_synthase PF00275.20 EEA25601.1 - 2.5e-123 411.9 0.0 3.9e-123 411.3 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EEA25601.1 - 6.8e-101 336.8 0.1 1.1e-100 336.2 0.1 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EEA25601.1 - 1.5e-56 192.2 0.0 4.4e-56 190.7 0.0 1.9 2 0 0 2 2 2 1 Type I 3-dehydroquinase SKI PF01202.22 EEA25601.1 - 1.2e-38 132.8 0.0 1.4e-36 126.0 0.0 2.7 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 EEA25601.1 - 5.5e-24 84.2 0.0 1.7e-23 82.6 0.0 2.0 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EEA25601.1 - 8.6e-09 35.0 0.3 2.9e-08 33.3 0.1 2.0 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 EEA25601.1 - 1.4e-08 34.8 0.0 3.5e-08 33.5 0.0 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.20 EEA25601.1 - 0.00015 21.8 0.0 0.00043 20.3 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_16 PF13191.6 EEA25601.1 - 0.0012 19.3 0.8 1.7 9.0 0.0 3.8 4 0 0 4 4 4 1 AAA ATPase domain AAA_18 PF13238.6 EEA25601.1 - 0.024 15.2 0.0 0.06 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sacchrp_dh_NADP PF03435.18 EEA25601.1 - 0.024 14.9 0.0 0.16 12.3 0.0 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain AAA_24 PF13479.6 EEA25601.1 - 0.029 14.1 0.1 0.082 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EEA25601.1 - 0.049 13.7 0.0 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EEA25601.1 - 0.082 13.2 0.0 0.41 10.9 0.0 2.2 1 0 0 1 1 1 0 AAA domain zf-C2H2 PF00096.26 EEA25602.1 - 3e-10 40.0 13.8 0.00016 22.0 1.4 4.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA25602.1 - 5.2e-06 26.8 10.8 0.029 15.2 1.1 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA25602.1 - 0.18 12.3 6.3 19 5.9 1.1 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-BED PF02892.15 EEA25602.1 - 0.35 10.9 2.0 0.88 9.7 2.0 1.7 1 0 0 1 1 1 0 BED zinc finger zf-Di19 PF05605.12 EEA25602.1 - 0.64 10.4 6.5 0.93 9.8 1.5 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CENP-T_C PF15511.6 EEA25603.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EEA25603.1 - 2.4e-05 24.7 0.1 2.8e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EEA25603.1 - 7.2e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EEA25603.1 - 0.0002 21.6 0.1 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EEA25603.1 - 0.0004 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EEA25603.1 - 0.0085 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EEA25603.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EEA25603.1 - 0.052 13.3 0.2 0.064 13.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 EEA25603.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region Histone PF00125.24 EEA25604.1 - 1e-51 174.7 2.5 1.1e-51 174.6 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EEA25604.1 - 6e-06 26.6 0.0 9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EEA25604.1 - 4.9e-05 23.4 0.5 7.4e-05 22.8 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EEA25604.1 - 6.5e-05 23.5 1.2 7.7e-05 23.3 1.2 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EEA25604.1 - 0.0032 17.7 0.3 0.0065 16.7 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EEA25604.1 - 0.026 14.6 0.2 0.042 13.9 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit MFS_1 PF07690.16 EEA25605.1 - 3.1e-41 141.5 45.9 3.1e-41 141.5 45.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA25605.1 - 1.2e-08 34.3 12.9 1.2e-08 34.3 12.9 2.5 1 1 1 2 2 2 1 Sugar (and other) transporter Anophelin PF10731.9 EEA25605.1 - 0.022 14.6 0.5 0.059 13.2 0.5 1.7 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Mpv17_PMP22 PF04117.12 EEA25606.1 - 3.6e-16 59.1 0.2 3.6e-16 59.1 0.2 2.2 2 1 1 3 3 3 1 Mpv17 / PMP22 family Exo5 PF09810.9 EEA25607.1 - 3.4e-140 467.7 0.0 5.8e-140 467.0 0.0 1.4 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EEA25607.1 - 0.00013 21.9 0.0 0.85 9.5 0.0 3.3 2 1 0 2 2 2 2 PD-(D/E)XK nuclease superfamily DUF3799 PF12684.7 EEA25607.1 - 0.0033 17.2 0.0 0.0081 15.9 0.0 1.6 2 0 0 2 2 2 1 PDDEXK-like domain of unknown function (DUF3799) DUF3445 PF11927.8 EEA25608.1 - 3e-80 269.1 0.0 4.2e-80 268.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) DUF4079 PF13301.6 EEA25608.1 - 0.034 14.3 0.0 0.049 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) OPT PF03169.15 EEA25609.1 - 2e-161 538.7 16.6 2.3e-161 538.5 16.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein SH3_9 PF14604.6 EEA25610.1 - 1.7e-07 30.9 0.0 2.8e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Podoplanin PF05808.11 EEA25610.1 - 1.9e-06 28.1 7.5 3.9e-06 27.1 7.5 1.6 1 0 0 1 1 1 1 Podoplanin SH3_1 PF00018.28 EEA25610.1 - 3.2e-05 23.4 0.0 4.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EEA25610.1 - 4.9e-05 22.9 0.0 8.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain CYYR1 PF10873.8 EEA25610.1 - 0.00071 20.0 0.0 0.00071 20.0 0.0 3.2 3 0 0 3 3 3 1 Cysteine and tyrosine-rich protein 1 DUF2613 PF11021.8 EEA25610.1 - 0.012 15.7 4.7 0.012 15.7 4.7 4.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) CEBP1_N PF16368.5 EEA25610.1 - 0.013 15.1 10.5 0.021 14.3 10.5 1.3 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein 1 N-terminus LapA_dom PF06305.11 EEA25610.1 - 0.041 13.7 0.2 0.041 13.7 0.2 1.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain GT87 PF09594.10 EEA25610.1 - 0.24 11.1 3.6 2.4 7.8 0.1 2.7 3 0 0 3 3 3 0 Glycosyltransferase family 87 Pkinase PF00069.25 EEA25611.1 - 3.6e-42 144.6 0.0 5e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25611.1 - 3.9e-15 55.8 0.0 5.8e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase KIX_2 PF16987.5 EEA25611.1 - 0.00041 20.3 0.4 0.00081 19.3 0.4 1.5 1 0 0 1 1 1 1 KIX domain APH PF01636.23 EEA25611.1 - 0.0072 16.3 0.1 0.95 9.3 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 EEA25612.1 - 1.2e-39 136.3 0.0 1.9e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25612.1 - 3.8e-15 55.9 0.0 5.5e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase KIX_2 PF16987.5 EEA25612.1 - 0.0004 20.3 0.4 0.00079 19.4 0.4 1.5 1 0 0 1 1 1 1 KIX domain APH PF01636.23 EEA25612.1 - 0.007 16.3 0.1 0.93 9.4 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family muHD PF10291.9 EEA25613.1 - 2.5e-84 282.8 0.4 3.5e-84 282.3 0.4 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EEA25613.1 - 2.3e-06 27.8 0.1 1.4e-05 25.3 0.0 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Laminin_II PF06009.12 EEA25613.1 - 0.15 12.0 1.6 0.39 10.7 1.6 1.7 1 0 0 1 1 1 0 Laminin Domain II COG2 PF06148.11 EEA25613.1 - 0.29 11.2 1.1 1.1 9.4 0.1 2.3 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 MAD PF05557.13 EEA25614.1 - 3.1e-60 204.3 77.0 3.4e-51 174.5 78.3 2.7 2 1 0 2 2 2 2 Mitotic checkpoint protein Ribosomal_L7Ae PF01248.26 EEA25615.1 - 5.7e-20 70.9 1.0 6.1e-19 67.6 1.0 2.5 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Colicin_Pyocin PF01320.18 EEA25615.1 - 0.02 15.0 0.2 0.02 15.0 0.2 1.9 2 0 0 2 2 2 0 Colicin immunity protein / pyocin immunity protein MSC PF09402.10 EEA25615.1 - 0.028 13.9 0.8 0.047 13.2 0.8 1.3 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Ribosomal_L7Ae PF01248.26 EEA25616.1 - 1.6e-24 85.4 0.0 1.8e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L7Ae PF01248.26 EEA25617.1 - 1.5e-15 56.7 0.0 1.8e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FAM163 PF15069.6 EEA25618.1 - 0.011 16.1 0.6 0.47 10.9 0.0 2.4 2 0 0 2 2 2 0 FAM163 family Shisa PF13908.6 EEA25618.1 - 0.016 15.5 0.3 0.049 13.9 0.0 1.9 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator FLYWCH PF04500.16 EEA25618.1 - 0.093 12.9 1.0 0.23 11.6 0.5 1.9 2 0 0 2 2 2 0 FLYWCH zinc finger domain Conotoxin PF02950.17 EEA25618.1 - 0.25 12.4 2.1 3 8.9 0.0 2.8 2 0 0 2 2 2 0 Conotoxin MMR_HSR1_C PF08438.10 EEA25621.1 - 9.6e-36 122.8 0.0 2.6e-35 121.4 0.0 1.8 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EEA25621.1 - 4e-16 59.1 0.0 1.1e-15 57.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA25621.1 - 1.9e-05 24.2 0.0 0.00017 21.2 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EEA25621.1 - 0.0061 16.1 0.5 0.63 9.6 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EEA25621.1 - 0.018 15.5 0.2 0.81 10.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter MMR_HSR1_Xtn PF16897.5 EEA25621.1 - 0.033 14.2 0.2 0.077 13.0 0.2 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain KTI12 PF08433.10 EEA25621.1 - 0.069 12.6 0.1 0.22 11.0 0.0 1.8 2 1 0 2 2 2 0 Chromatin associated protein KTI12 Dynamin_N PF00350.23 EEA25621.1 - 0.092 12.8 1.4 0.23 11.5 0.3 2.2 3 0 0 3 3 3 0 Dynamin family Ploopntkinase3 PF18751.1 EEA25621.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_16 PF13191.6 EEA25621.1 - 0.12 12.8 0.0 0.31 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain ATP_bind_1 PF03029.17 EEA25621.1 - 0.12 12.1 0.1 18 5.0 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Zip PF02535.22 EEA25622.1 - 1.9 7.7 4.5 2 7.5 4.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SET PF00856.28 EEA25623.1 - 0.0098 16.3 0.0 0.038 14.4 0.0 1.9 2 0 0 2 2 2 1 SET domain DUF4145 PF13643.6 EEA25623.1 - 0.032 14.4 0.0 0.065 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) Fungal_trans PF04082.18 EEA25624.1 - 5.6e-32 110.8 0.0 9.1e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25624.1 - 7.9e-08 32.3 16.0 1.3e-07 31.6 16.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_1 PF00170.21 EEA25624.1 - 0.24 11.5 0.0 0.24 11.5 0.0 2.3 3 0 0 3 3 3 0 bZIP transcription factor Fungal_trans PF04082.18 EEA25625.1 - 1.1e-19 70.6 0.1 1.6e-19 70.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25625.1 - 2.2e-10 40.5 10.5 3.8e-10 39.7 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transketolase_N PF00456.21 EEA25626.1 - 3.3e-152 506.3 0.1 4.5e-152 505.8 0.1 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EEA25626.1 - 6e-44 149.8 0.0 1e-43 149.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EEA25626.1 - 2.1e-11 43.8 0.0 4.7e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EEA25626.1 - 5.4e-05 22.5 0.1 0.0023 17.2 0.0 2.2 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 EEA25626.1 - 0.023 13.7 0.0 0.041 12.8 0.0 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component Beta_elim_lyase PF01212.21 EEA25626.1 - 0.084 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase ThiP_synth PF10120.9 EEA25626.1 - 0.16 11.5 0.4 7.2 6.2 0.0 2.2 2 0 0 2 2 2 0 Thiamine-phosphate synthase Spermine_synth PF01564.17 EEA25627.1 - 5.1e-75 251.0 0.0 7.4e-75 250.5 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EEA25627.1 - 2.6e-25 88.1 0.2 4.4e-25 87.3 0.2 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EEA25627.1 - 0.00011 22.8 0.0 0.00028 21.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA25627.1 - 0.0032 18.2 0.2 0.024 15.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EEA25627.1 - 0.011 14.9 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_18 PF12847.7 EEA25627.1 - 0.033 14.1 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Spermine_synth PF01564.17 EEA25628.1 - 1.4e-74 249.6 0.0 1.7e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_25 PF13649.6 EEA25628.1 - 7.7e-05 23.3 0.0 0.00016 22.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.16 EEA25628.1 - 0.0063 15.8 0.0 0.0084 15.4 0.0 1.2 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Methyltransf_12 PF08242.12 EEA25628.1 - 0.0067 17.1 0.0 0.014 16.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EEA25628.1 - 0.02 14.8 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 EEA25628.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_30 PF05430.11 EEA25628.1 - 0.16 11.9 0.0 0.39 10.6 0.0 1.7 2 0 0 2 2 2 0 S-adenosyl-L-methionine-dependent methyltransferase Spermine_synth PF01564.17 EEA25629.1 - 5.5e-74 247.6 0.0 8.1e-74 247.1 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EEA25629.1 - 2.6e-25 88.1 0.2 4.4e-25 87.3 0.2 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EEA25629.1 - 0.00011 22.8 0.0 0.00029 21.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA25629.1 - 0.0033 18.1 0.2 0.024 15.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EEA25629.1 - 0.011 15.0 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_18 PF12847.7 EEA25629.1 - 0.033 14.1 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UcrQ PF02939.16 EEA25630.1 - 7.5e-33 112.3 0.2 9e-33 112.0 0.2 1.1 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 EEA25630.1 - 0.036 14.5 0.0 0.048 14.1 0.0 1.2 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 Protamine_like PF06382.11 EEA25630.1 - 0.18 12.0 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Protamine and protamine like Band_7 PF01145.25 EEA25631.1 - 3.1e-24 86.0 7.5 6.8e-24 84.8 7.5 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EEA25631.1 - 0.0015 17.6 3.9 0.002 17.3 3.9 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial PknG_rubred PF16919.5 EEA25631.1 - 0.08 13.1 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain Methyltransf_34 PF11312.8 EEA25632.1 - 8.3e-106 353.7 0.1 1.2e-105 353.2 0.1 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Borrelia_P83 PF05262.11 EEA25633.1 - 0.047 12.2 6.9 0.089 11.3 6.9 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein Abhydrolase_3 PF07859.13 EEA25634.1 - 8.9e-37 127.0 0.0 1.2e-36 126.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA25634.1 - 9.7e-05 21.9 0.0 0.00017 21.1 0.0 1.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EEA25634.1 - 0.00018 21.1 0.0 0.24 10.9 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Esterase PF00756.20 EEA25634.1 - 0.0014 18.3 0.0 0.87 9.2 0.0 2.3 2 1 0 2 2 2 2 Putative esterase AXE1 PF05448.12 EEA25634.1 - 0.062 12.0 0.0 7.3 5.2 0.0 2.2 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) COesterase PF00135.28 EEA25634.1 - 0.094 11.6 0.0 0.23 10.3 0.0 1.5 2 0 0 2 2 2 0 Carboxylesterase family DUF2974 PF11187.8 EEA25634.1 - 0.19 11.2 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Aldo_ket_red PF00248.21 EEA25635.1 - 5.5e-49 166.9 0.0 6.3e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Tubulin PF00091.25 EEA25638.1 - 4.9e-69 232.5 0.0 8.2e-69 231.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EEA25638.1 - 5.7e-45 152.5 1.5 6.5e-45 152.4 0.2 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EEA25638.1 - 9e-07 29.2 0.0 2.4e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EEA25638.1 - 0.04 13.6 0.0 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 Tubulin domain DUF202 PF02656.15 EEA25639.1 - 2.9e-22 78.9 0.9 2.9e-22 78.9 0.9 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF202) DUF202 PF02656.15 EEA25640.1 - 2.9e-22 78.9 0.9 2.9e-22 78.9 0.9 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF202) DUF202 PF02656.15 EEA25641.1 - 2.9e-22 78.9 0.9 2.9e-22 78.9 0.9 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF202) DUF202 PF02656.15 EEA25642.1 - 2.9e-22 78.9 0.9 2.9e-22 78.9 0.9 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF202) PTPA PF03095.15 EEA25643.1 - 6.1e-109 364.1 0.0 7.3e-109 363.9 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein NLRC4_HD2 PF17776.1 EEA25643.1 - 0.02 15.4 0.0 2.1 8.9 0.0 3.1 3 0 0 3 3 3 0 NLRC4 helical domain HD2 RRM_occluded PF16842.5 EEA25643.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif zf-AN1 PF01428.16 EEA25644.1 - 9.6e-13 48.1 6.0 9.6e-13 48.1 6.0 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EEA25644.1 - 0.11 12.8 8.3 0.055 13.8 6.3 1.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain DUF1754 PF08555.10 EEA25645.1 - 4.5e-13 49.8 16.1 7.1e-13 49.2 16.1 1.3 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Phlebovirus_NSM PF07246.11 EEA25645.1 - 1.3 8.3 9.0 2 7.7 9.0 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M FYVE_2 PF02318.16 EEA25645.1 - 2.4 8.4 6.0 0.44 10.8 2.7 1.6 2 0 0 2 2 2 0 FYVE-type zinc finger PRP1_N PF06424.12 EEA25645.1 - 4.1 7.8 12.3 15 5.9 12.3 1.7 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF1754 PF08555.10 EEA25646.1 - 1.4e-12 48.2 16.6 2.1e-12 47.7 16.6 1.2 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Phlebovirus_NSM PF07246.11 EEA25646.1 - 3.9 6.8 6.3 5 6.4 6.3 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M EamA PF00892.20 EEA25647.1 - 2.1e-13 50.6 24.6 2e-06 28.0 0.6 2.4 2 0 0 2 2 2 2 EamA-like transporter family CSG2 PF16965.5 EEA25647.1 - 9.9e-05 21.5 13.9 0.0029 16.6 13.9 2.5 1 1 0 1 1 1 1 Ceramide synthase regulator SLC35F PF06027.12 EEA25647.1 - 0.0015 18.1 3.7 0.0015 18.1 3.7 1.6 2 0 0 2 2 2 1 Solute carrier family 35 UAA PF08449.11 EEA25647.1 - 0.031 13.5 4.8 0.03 13.6 3.9 1.5 1 1 0 1 1 1 0 UAA transporter family Nuc_sug_transp PF04142.15 EEA25647.1 - 0.039 13.1 7.6 0.16 11.2 7.6 1.8 1 1 0 1 1 1 0 Nucleotide-sugar transporter DUF202 PF02656.15 EEA25647.1 - 0.041 14.3 1.9 0.041 14.3 1.9 4.6 4 2 0 4 4 4 0 Domain of unknown function (DUF202) DUF4395 PF14340.6 EEA25647.1 - 5.3 7.4 13.5 0.72 10.2 0.7 4.3 2 1 1 4 4 4 0 Domain of unknown function (DUF4395) Actin PF00022.19 EEA25648.1 - 3.7e-110 368.3 0.0 2.5e-109 365.6 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EEA25648.1 - 0.0016 17.3 0.0 0.0049 15.7 0.0 1.7 1 1 0 1 1 1 1 MreB/Mbl protein NAD_binding_2 PF03446.15 EEA25649.1 - 7.7e-25 87.9 0.0 1.1e-24 87.4 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA25649.1 - 9e-12 45.3 0.0 1.8e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF3425 PF11905.8 EEA25650.1 - 1.6e-18 66.8 2.2 3.1e-18 65.9 2.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EEA25650.1 - 0.0091 16.1 12.8 0.039 14.0 11.6 2.1 1 1 1 2 2 2 1 bZIP transcription factor COG5 PF10392.9 EEA25650.1 - 0.018 15.2 1.4 5.8 7.1 2.7 2.2 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Phage_portal PF04860.12 EEA25650.1 - 0.067 12.4 0.3 3.2 6.9 0.2 2.2 2 0 0 2 2 2 0 Phage portal protein CENP-F_leu_zip PF10473.9 EEA25650.1 - 0.15 12.1 3.1 0.24 11.4 3.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact PF15898.5 EEA25650.1 - 0.83 10.6 6.2 1.5 9.7 6.2 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain bZIP_2 PF07716.15 EEA25650.1 - 6.2 7.0 14.0 0.27 11.3 5.5 2.2 2 0 0 2 2 2 0 Basic region leucine zipper GTP_cyclohydro2 PF00925.20 EEA25651.1 - 1.1e-56 190.9 0.0 1.6e-56 190.4 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II PsbQ PF05757.11 EEA25651.1 - 0.13 12.0 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) DUF1325 PF07039.11 EEA25652.1 - 1.3e-33 115.9 0.7 2.9e-33 114.8 0.0 2.0 2 0 0 2 2 2 1 SGF29 tudor-like domain LBR_tudor PF09465.10 EEA25652.1 - 0.056 13.3 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain DUF3381 PF11861.8 EEA25652.1 - 2.6 7.8 18.6 0.57 10.0 8.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF1325 PF07039.11 EEA25653.1 - 1.2e-33 116.0 0.8 2.6e-33 114.9 0.0 2.0 2 0 0 2 2 2 1 SGF29 tudor-like domain LBR_tudor PF09465.10 EEA25653.1 - 0.053 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain DUF3381 PF11861.8 EEA25653.1 - 2 8.2 18.6 0.53 10.1 8.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) SR-25 PF10500.9 EEA25653.1 - 5.2 6.6 44.4 0.29 10.7 17.7 3.2 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein DUF1325 PF07039.11 EEA25654.1 - 3.8e-29 101.4 2.6 3.2e-27 95.2 0.0 3.0 3 0 0 3 3 3 2 SGF29 tudor-like domain LBR_tudor PF09465.10 EEA25654.1 - 0.059 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain DUF3381 PF11861.8 EEA25654.1 - 2.5 7.9 18.6 0.56 10.0 8.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) SR-25 PF10500.9 EEA25654.1 - 6.6 6.3 44.4 0.3 10.6 17.7 3.2 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein PMI_typeI PF01238.21 EEA25655.1 - 1.4e-146 488.5 0.0 1.6e-146 488.3 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 EEA25655.1 - 0.11 12.4 0.0 30 4.5 0.0 2.8 3 0 0 3 3 3 0 AraC-like ligand binding domain Coatomer_E PF04733.14 EEA25656.1 - 5e-63 213.2 5.8 5.7e-63 213.0 5.8 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EEA25656.1 - 8.1e-11 42.3 16.3 8.3e-05 23.0 2.7 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA25656.1 - 5e-08 33.1 0.8 0.0017 18.5 0.8 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EEA25656.1 - 6.7e-08 33.1 10.7 0.014 16.0 4.7 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 EEA25656.1 - 2.8e-06 27.4 14.2 0.042 14.5 0.4 4.4 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 EEA25656.1 - 9.2e-06 26.0 4.1 1.5 9.6 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA25656.1 - 6.5e-05 23.4 15.6 0.005 17.5 0.1 5.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA25656.1 - 0.00015 22.0 10.8 0.0078 16.5 3.0 3.8 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA25656.1 - 0.00094 18.9 4.2 0.23 11.3 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA25656.1 - 0.0016 18.4 15.6 0.015 15.4 0.1 5.1 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EEA25656.1 - 0.0031 16.8 8.3 0.0072 15.6 3.0 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA25656.1 - 0.0098 16.2 1.1 2 9.0 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA25656.1 - 0.035 14.0 6.1 4.3 7.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 EEA25656.1 - 0.097 12.8 5.4 0.34 11.1 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Type_III_YscG PF09477.10 EEA25656.1 - 0.1 12.7 5.0 0.23 11.5 1.3 3.0 2 2 2 4 4 4 0 Bacterial type II secretion system chaperone protein (type_III_yscG) NTP_transferase PF00483.23 EEA25656.1 - 0.13 11.8 0.9 0.2 11.2 0.9 1.3 1 0 0 1 1 1 0 Nucleotidyl transferase AhpC-TSA_2 PF13911.6 EEA25658.1 - 5.9e-13 48.9 0.0 1.1e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Glyco_hydro_16 PF00722.21 EEA25659.1 - 9.9e-40 135.9 4.2 9.9e-40 135.9 4.2 2.2 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 GREB1 PF15782.5 EEA25659.1 - 6.1 3.8 9.1 7.9 3.5 9.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Stanniocalcin PF03298.13 EEA25661.1 - 0.00069 19.0 0.0 0.00075 18.9 0.0 1.2 1 0 0 1 1 1 1 Stanniocalcin family MID_MedPIWI PF18296.1 EEA25661.1 - 0.076 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 MID domain of medPIWI PI-PLC-X PF00388.19 EEA25662.1 - 9.5e-60 200.4 0.0 1.8e-59 199.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EEA25662.1 - 1.1e-45 154.7 0.1 3.1e-42 143.5 0.1 2.6 2 0 0 2 2 2 2 Phosphatidylinositol-specific phospholipase C, Y domain GDPD PF03009.17 EEA25662.1 - 0.0044 16.8 0.0 0.0096 15.7 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EF-hand_like PF09279.11 EEA25662.1 - 0.026 15.0 0.1 0.068 13.7 0.0 1.7 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.32 EEA25662.1 - 0.054 13.1 0.1 0.69 9.6 0.0 2.8 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 EEA25662.1 - 0.13 12.7 0.8 0.46 11.0 0.2 2.3 2 0 0 2 2 2 0 EF-hand domain pair DUF3439 PF11921.8 EEA25662.1 - 2.6 8.1 8.6 5.9 6.9 8.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) UPF1_Zn_bind PF09416.10 EEA25663.1 - 1.4e-71 239.4 3.0 1.8e-71 239.1 1.6 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EEA25663.1 - 7.3e-59 198.7 0.0 1.5e-58 197.7 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.6 EEA25663.1 - 1.8e-54 185.3 2.7 3.4e-31 109.0 0.2 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 EEA25663.1 - 1.6e-33 114.8 0.0 3e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EEA25663.1 - 1.4e-13 51.0 0.3 2e-12 47.2 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA25663.1 - 3e-11 43.8 0.0 2.5e-10 40.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EEA25663.1 - 7.9e-06 26.0 0.0 1.5e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EEA25663.1 - 3.2e-05 23.8 0.2 0.31 10.8 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 EEA25663.1 - 0.0006 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Helicase DUF2075 PF09848.9 EEA25663.1 - 0.0006 19.2 0.1 0.012 14.9 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 EEA25663.1 - 0.002 17.7 0.0 0.024 14.2 0.0 2.3 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 EEA25663.1 - 0.0025 17.1 0.1 0.57 9.3 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase DEAD PF00270.29 EEA25663.1 - 0.0074 16.1 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_10 PF12846.7 EEA25663.1 - 0.014 14.3 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain ATPase PF06745.13 EEA25663.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 EEA25663.1 - 0.14 12.5 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ribosomal_S27e PF01667.17 EEA25663.1 - 0.61 9.8 3.2 0.7 9.6 0.8 2.2 2 0 0 2 2 2 0 Ribosomal protein S27 zf-UBP PF02148.19 EEA25663.1 - 3.1 8.2 7.4 7.7 6.9 7.4 1.7 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein Brix PF04427.18 EEA25664.1 - 1.4e-30 106.8 0.0 1.8e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Brix domain BRCT PF00533.26 EEA25665.1 - 3.5e-08 33.7 0.5 6.8e-08 32.8 0.1 1.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EEA25665.1 - 3.8e-08 33.2 0.1 8e-08 32.1 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain WGR PF05406.15 EEA25665.1 - 5e-05 23.3 0.1 0.0001 22.3 0.1 1.5 1 0 0 1 1 1 1 WGR domain BRCT_2 PF16589.5 EEA25665.1 - 5.7e-05 23.4 0.0 0.00015 22.1 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EEA25665.1 - 0.00026 21.2 0.2 0.00079 19.7 0.0 1.9 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EEA25665.1 - 0.023 14.8 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain IGPS PF00218.21 EEA25666.1 - 2e-96 322.1 0.0 1.1e-95 319.6 0.0 1.9 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EEA25666.1 - 1.2e-55 188.4 0.0 2.8e-51 174.0 0.0 2.6 2 1 1 3 3 3 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EEA25666.1 - 3.8e-46 157.3 0.0 6.2e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EEA25666.1 - 4.4e-05 23.3 0.1 0.00016 21.5 0.1 1.8 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 EEA25666.1 - 0.00078 19.3 1.0 0.05 13.4 0.0 3.1 3 0 0 3 3 3 1 Quinolinate phosphoribosyl transferase, C-terminal domain NanE PF04131.14 EEA25666.1 - 0.002 17.3 0.2 0.056 12.6 0.0 2.7 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 EEA25666.1 - 0.023 14.1 0.5 0.25 10.8 0.0 2.5 3 0 0 3 3 3 0 Histidine biosynthesis protein Peripla_BP_2 PF01497.18 EEA25666.1 - 0.05 13.2 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein Nup188_C PF18378.1 EEA25667.1 - 3.2e-143 477.1 0.7 5.8e-143 476.2 0.7 1.5 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 EEA25667.1 - 1.1e-75 255.3 1.7 6.1e-64 216.4 0.4 2.3 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 DUF465 PF04325.13 EEA25667.1 - 0.11 12.5 0.0 0.43 10.6 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF465) DUF4570 PF15134.6 EEA25667.1 - 0.3 11.1 1.3 0.83 9.7 1.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) G-alpha PF00503.20 EEA25668.1 - 5.5e-124 413.9 1.0 6.4e-124 413.7 1.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EEA25668.1 - 2.6e-15 56.3 1.5 3.1e-10 39.8 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 EEA25668.1 - 1.3e-05 24.9 0.0 5.5e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger Gtr1_RagA PF04670.12 EEA25668.1 - 0.00097 18.5 1.7 0.067 12.5 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EEA25668.1 - 0.0056 16.4 0.1 0.041 13.6 0.1 2.2 1 1 1 2 2 2 1 P-loop containing region of AAA domain Roc PF08477.13 EEA25668.1 - 0.02 15.1 0.8 2.4 8.4 0.0 2.9 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EEA25668.1 - 0.072 12.2 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain MMR_HSR1 PF01926.23 EEA25668.1 - 0.12 12.5 0.1 8.7 6.5 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA25668.1 - 0.13 11.8 0.1 1.7 8.1 0.1 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 EEA25668.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family G-alpha PF00503.20 EEA25669.1 - 5.5e-124 413.9 1.0 6.4e-124 413.7 1.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EEA25669.1 - 2.6e-15 56.3 1.5 3.1e-10 39.8 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 EEA25669.1 - 1.3e-05 24.9 0.0 5.5e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger Gtr1_RagA PF04670.12 EEA25669.1 - 0.00097 18.5 1.7 0.067 12.5 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EEA25669.1 - 0.0056 16.4 0.1 0.041 13.6 0.1 2.2 1 1 1 2 2 2 1 P-loop containing region of AAA domain Roc PF08477.13 EEA25669.1 - 0.02 15.1 0.8 2.4 8.4 0.0 2.9 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EEA25669.1 - 0.072 12.2 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain MMR_HSR1 PF01926.23 EEA25669.1 - 0.12 12.5 0.1 8.7 6.5 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA25669.1 - 0.13 11.8 0.1 1.7 8.1 0.1 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 EEA25669.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Use1 PF09753.9 EEA25670.1 - 5e-09 36.2 1.4 2.4e-08 34.0 1.4 2.0 1 1 0 1 1 1 1 Membrane fusion protein Use1 Snapin_Pallidin PF14712.6 EEA25670.1 - 0.09 13.2 0.1 0.26 11.7 0.1 1.8 1 0 0 1 1 1 0 Snapin/Pallidin Sacchrp_dh_NADP PF03435.18 EEA25671.1 - 1.4e-10 41.5 0.0 2.3e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF3640 PF12342.8 EEA25672.1 - 0.077 12.7 0.3 7.1 6.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3640) DUF1771 PF08590.10 EEA25674.1 - 3.5e-25 88.1 8.4 1.1e-24 86.5 8.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 EEA25674.1 - 1.7e-11 44.3 0.7 5.7e-11 42.6 0.4 2.1 2 0 0 2 2 2 1 Smr domain CsgA PF17334.2 EEA25674.1 - 0.53 11.1 4.7 7.5 7.4 1.1 2.6 3 0 0 3 3 3 0 Minor curli fiber component A DUF4407 PF14362.6 EEA25674.1 - 0.69 9.2 2.6 1.1 8.5 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peripla_BP_3 PF13377.6 EEA25674.1 - 1.2 9.5 3.1 1.1 9.5 0.2 2.1 2 0 0 2 2 2 0 Periplasmic binding protein-like domain polyprenyl_synt PF00348.17 EEA25675.1 - 9.3e-68 228.0 0.0 1.2e-67 227.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CDC14 PF08045.11 EEA25676.1 - 1.2e-131 438.0 0.0 1.4e-131 437.8 0.0 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component End3 PF12761.7 EEA25677.1 - 2.4e-71 240.1 1.9 3.3e-71 239.6 1.9 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EEA25677.1 - 5.3e-53 177.3 0.1 1.7e-49 166.1 0.1 2.3 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EEA25677.1 - 1.7e-08 33.4 0.3 1.8e-07 30.2 0.3 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EEA25677.1 - 1.4e-06 28.6 2.9 5e-06 26.9 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EEA25677.1 - 2.3e-05 24.2 0.1 0.0049 16.7 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EEA25677.1 - 3.5e-05 23.4 0.6 0.0004 20.1 0.2 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 EEA25677.1 - 0.0023 17.3 1.0 0.0095 15.4 0.2 2.3 2 0 0 2 2 2 1 EF hand RPW8 PF05659.11 EEA25677.1 - 0.0068 16.1 1.7 0.017 14.8 0.3 2.0 2 0 0 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF4407 PF14362.6 EEA25677.1 - 0.37 10.1 6.4 0.98 8.7 6.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4201 PF13870.6 EEA25677.1 - 0.92 9.2 11.5 0.21 11.3 5.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 EEA25677.1 - 1.5 8.9 9.0 0.71 9.9 1.7 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein RRP36 PF06102.12 EEA25677.1 - 2.8 7.9 10.8 0.18 11.7 3.4 2.2 1 1 1 2 2 2 0 rRNA biogenesis protein RRP36 Spc7 PF08317.11 EEA25677.1 - 2.9 6.7 10.2 0.92 8.3 5.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein SNF2_N PF00176.23 EEA25678.1 - 3.9e-64 216.6 0.2 1.2e-63 215.0 0.1 1.7 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA25678.1 - 4.8e-23 81.6 0.5 5.2e-22 78.3 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA25678.1 - 2.1e-07 31.1 0.0 7.1e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA25678.1 - 1e-05 24.9 0.0 3.1e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 EEA25678.1 - 2.9e-05 23.4 0.0 0.005 16.1 0.0 3.4 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 AT_hook PF02178.19 EEA25679.1 - 0.013 15.3 2.1 0.045 13.6 2.1 2.1 1 0 0 1 1 1 0 AT hook motif DSPc PF00782.20 EEA25680.1 - 2.8e-13 49.8 0.0 1.5e-12 47.4 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EEA25680.1 - 0.019 15.3 0.0 0.033 14.5 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain Acyl_CoA_thio PF02551.15 EEA25680.1 - 0.065 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Acyl-CoA thioesterase zf-C2H2_aberr PF17017.5 EEA25681.1 - 1.4e-06 28.5 0.3 3.6e-06 27.2 0.1 1.7 2 0 0 2 2 2 1 Aberrant zinc-finger zf-C2H2 PF00096.26 EEA25681.1 - 3.6e-06 27.1 15.1 0.14 12.6 2.4 3.9 3 1 0 3 3 3 3 Zinc finger, C2H2 type Cnn_1N PF07989.11 EEA25681.1 - 0.01 16.0 0.7 0.028 14.6 0.4 1.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Transpos_assoc PF13963.6 EEA25681.1 - 0.027 14.8 3.0 0.12 12.7 0.2 2.3 2 0 0 2 2 2 0 Transposase-associated domain Trimer_CC PF08954.11 EEA25681.1 - 0.03 13.9 0.5 0.065 12.8 0.5 1.5 1 0 0 1 1 1 0 Trimerisation motif zf-C2H2_4 PF13894.6 EEA25681.1 - 0.038 14.8 7.6 18 6.5 0.6 3.8 3 1 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA25681.1 - 0.84 10.2 10.9 7.2 7.2 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger double domain GST_N_3 PF13417.6 EEA25682.1 - 4.8e-06 26.9 0.0 1.1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA25682.1 - 0.00017 21.8 0.0 0.00041 20.6 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA25682.1 - 0.0029 17.9 0.0 0.0068 16.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain A_deaminase PF00962.22 EEA25684.1 - 1.3e-19 70.7 0.0 1.9e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase RVT_1 PF00078.27 EEA25685.1 - 4.1e-06 26.5 0.0 8.6e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CENP-B_dimeris PF09026.10 EEA25685.1 - 0.0025 18.2 15.3 0.024 15.0 3.1 3.5 3 0 0 3 3 3 2 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EEA25685.1 - 0.77 10.2 18.3 0.75 10.2 0.4 3.9 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Transp_cyt_pur PF02133.15 EEA25686.1 - 1.1e-152 508.9 45.2 1.3e-152 508.7 45.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Urb2 PF10441.9 EEA25687.1 - 3.4e-57 193.7 0.4 3.9e-56 190.2 0.0 3.1 3 0 0 3 3 3 1 Urb2/Npa2 family DUF543 PF04418.12 EEA25688.1 - 1.4e-28 98.7 0.0 1.5e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Copper-fist PF00649.18 EEA25689.1 - 3.3e-17 61.7 0.3 3.3e-17 61.7 0.3 1.8 2 0 0 2 2 2 1 Copper fist DNA binding domain Metallothio_2 PF01439.18 EEA25689.1 - 1.8 9.5 24.5 0.16 12.9 2.3 3.6 4 0 0 4 4 4 0 Metallothionein GST_N_4 PF17172.4 EEA25690.1 - 1.1e-21 77.4 0.1 2.2e-21 76.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EEA25690.1 - 3.1e-17 62.1 0.1 6.1e-17 61.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EEA25690.1 - 1.6e-12 47.8 0.2 4.7e-12 46.3 0.1 1.9 1 1 0 1 1 1 1 Outer mitochondrial membrane transport complex protein SAM35 PF10806.8 EEA25690.1 - 3.7e-06 27.2 0.0 7.7e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 SAM35, subunit of SAM coomplex GST_C_2 PF13410.6 EEA25690.1 - 0.035 14.1 0.0 0.075 13.1 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Methyltransf_31 PF13847.6 EEA25691.1 - 3.3e-09 36.7 0.0 5.7e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA25691.1 - 3.8e-09 37.1 0.0 1.2e-08 35.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA25691.1 - 3.6e-08 33.9 0.0 1.4e-07 32.1 0.0 2.1 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA25691.1 - 1.5e-07 32.0 0.0 3e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA25691.1 - 1.2e-06 28.5 0.0 1.8e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA25691.1 - 1.5e-05 24.5 0.0 3e-05 23.5 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_28 PF02636.17 EEA25691.1 - 0.00048 19.8 0.0 0.00066 19.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase CheR PF01739.18 EEA25691.1 - 0.00067 19.2 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_33 PF10017.9 EEA25691.1 - 0.00092 18.4 0.0 0.002 17.4 0.0 1.5 2 0 0 2 2 2 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_32 PF13679.6 EEA25691.1 - 0.0097 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_7 PF03492.15 EEA25691.1 - 0.021 14.1 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase PCMT PF01135.19 EEA25691.1 - 0.05 13.4 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 EEA25691.1 - 0.066 12.6 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.14 EEA25691.1 - 0.082 12.5 0.0 0.44 10.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain Mit_KHE1 PF10173.9 EEA25692.1 - 8.1e-63 211.9 1.4 1.3e-62 211.3 1.4 1.3 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related MARVEL PF01284.23 EEA25693.1 - 0.11 12.5 2.9 0.19 11.7 2.9 1.3 1 0 0 1 1 1 0 Membrane-associating domain Cupin_2 PF07883.11 EEA25694.1 - 0.00011 21.8 0.2 0.00019 21.1 0.2 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EEA25694.1 - 0.0014 18.2 0.3 0.0029 17.2 0.2 1.5 1 1 0 1 1 1 1 Cupin RNase_H PF00075.24 EEA25695.1 - 2.3e-11 44.0 0.0 4.3e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 EEA25695.1 - 2e-05 25.2 0.0 3.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_3 PF13456.6 EEA25695.1 - 0.028 14.2 0.0 0.051 13.4 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like Bys1 PF04681.12 EEA25696.1 - 1.9e-05 24.6 0.0 2.4e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Cullin PF00888.22 EEA25697.1 - 4.1e-192 640.1 13.4 5.6e-192 639.6 13.4 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EEA25697.1 - 1.4e-26 92.3 4.5 5.4e-26 90.4 4.5 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain WAC_Acf1_DNA_bd PF10537.9 EEA25697.1 - 0.1 13.1 2.7 0.38 11.3 0.9 2.9 2 0 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal AnfG_VnfG PF03139.15 EEA25697.1 - 0.41 10.8 10.1 0.04 14.0 1.5 3.4 3 1 1 4 4 4 0 Vanadium/alternative nitrogenase delta subunit CsgA PF17334.2 EEA25697.1 - 0.43 11.3 5.9 0.8 10.5 0.0 4.2 4 0 0 4 4 4 0 Minor curli fiber component A Phosphorylase PF00343.20 EEA25698.1 - 0 1051.3 0.0 0 1051.1 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DUF365 PF04033.12 EEA25698.1 - 0.019 15.3 0.2 6.8 7.0 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF365) Coatomer_b_Cpla PF14806.6 EEA25698.1 - 0.055 13.5 1.1 0.14 12.1 0.0 2.3 3 0 0 3 3 3 0 Coatomer beta subunit appendage platform G-alpha PF00503.20 EEA25699.1 - 9.7e-113 376.9 0.8 1.1e-112 376.7 0.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EEA25699.1 - 3.3e-15 56.0 1.0 2.6e-10 40.0 0.3 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA25699.1 - 2.3e-05 23.9 0.1 0.059 12.7 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region WAK PF08488.11 EEA25699.1 - 0.0018 18.8 0.1 0.021 15.3 0.0 2.2 2 0 0 2 2 2 1 Wall-associated kinase Roc PF08477.13 EEA25699.1 - 0.0027 17.9 0.5 0.85 9.8 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EEA25699.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pkinase PF00069.25 EEA25700.1 - 1.2e-66 224.8 0.0 1.5e-66 224.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25700.1 - 3.2e-31 108.6 0.0 4.3e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA25700.1 - 9.7e-06 24.8 0.1 1.3e-05 24.4 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA25700.1 - 0.00013 21.3 0.1 0.00044 19.7 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA25700.1 - 0.00028 20.3 0.0 0.052 12.9 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 EEA25700.1 - 0.00091 19.2 0.0 0.0025 17.8 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EEA25700.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EEA25700.1 - 0.041 13.5 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 EEA25701.1 - 1.1e-66 224.9 0.0 1.4e-66 224.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25701.1 - 2.9e-31 108.7 0.0 3.9e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA25701.1 - 9.3e-06 24.8 0.1 1.2e-05 24.4 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA25701.1 - 0.00012 21.5 0.1 0.00041 19.8 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA25701.1 - 0.00025 20.4 0.0 0.049 12.9 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 EEA25701.1 - 0.00087 19.3 0.0 0.0024 17.8 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EEA25701.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EEA25701.1 - 0.039 13.5 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Avl9 PF09794.9 EEA25702.1 - 1.4e-143 478.2 0.0 2.2e-143 477.5 0.0 1.3 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 EEA25702.1 - 4.1e-07 30.0 0.1 0.0013 18.7 0.0 2.6 1 1 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 EEA25702.1 - 7.4e-06 25.8 5.7 0.00046 19.9 0.7 3.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) Afi1 PF07792.12 EEA25702.1 - 1.2 9.6 0.0 1.2 9.6 0.0 3.0 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ABC_membrane_2 PF06472.15 EEA25703.1 - 1.1e-102 343.1 0.7 1.5e-102 342.6 0.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EEA25703.1 - 7.8e-18 65.3 0.0 1.6e-17 64.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EEA25703.1 - 7.5e-05 22.7 0.1 0.00021 21.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA25703.1 - 0.0042 17.6 0.2 0.012 16.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EEA25703.1 - 0.018 14.8 0.0 0.054 13.2 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Glyco_transf_22 PF03901.17 EEA25703.1 - 0.024 13.8 0.4 0.041 13.1 0.4 1.2 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family SMC_N PF02463.19 EEA25703.1 - 0.053 12.9 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 EEA25703.1 - 0.13 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_15 PF13175.6 EEA25703.1 - 0.18 11.5 0.0 0.43 10.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Fungal_trans PF04082.18 EEA25704.1 - 0.0001 21.4 0.2 0.00018 20.6 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25704.1 - 0.17 12.0 0.4 0.34 11.1 0.4 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DJ-1_PfpI PF01965.24 EEA25705.1 - 4e-12 46.2 0.0 6.7e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family LRR_6 PF13516.6 EEA25706.1 - 2e-05 24.3 0.4 1.9 8.8 0.0 5.0 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.7 EEA25706.1 - 0.0018 18.6 2.2 5.6 7.5 0.0 4.9 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) Ribosomal_L5e PF17144.4 EEA25707.1 - 6.7e-80 266.8 0.6 1.3e-79 265.9 0.6 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EEA25707.1 - 2.5e-34 118.1 9.8 2.5e-34 118.1 9.8 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.6 EEA25707.1 - 0.038 14.2 0.1 1.4 9.1 0.0 2.8 2 1 0 2 2 2 0 Threonine synthase N terminus Ribosomal_L18p PF00861.22 EEA25707.1 - 0.045 14.1 0.2 0.045 14.1 0.2 1.7 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Colicin_immun PF09204.10 EEA25707.1 - 0.52 10.9 5.3 0.4 11.2 2.5 2.3 2 1 0 2 2 2 0 Bacterial self-protective colicin-like immunity HAD_2 PF13419.6 EEA25708.1 - 3.8e-06 27.1 0.0 6.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA25708.1 - 0.0021 18.1 0.0 0.0036 17.3 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EEA25708.1 - 0.019 15.3 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA25709.1 - 3.8e-06 27.1 0.0 6.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA25709.1 - 0.0021 18.1 0.0 0.0036 17.3 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EEA25709.1 - 0.019 15.3 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase FTA4 PF13093.6 EEA25710.1 - 8.6e-60 202.1 4.9 9.9e-60 201.9 4.9 1.0 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF98 PF01947.16 EEA25710.1 - 0.015 15.3 0.3 0.029 14.3 0.0 1.6 2 0 0 2 2 2 0 p-hydroxybenzoic acid synthase AIG1 PF04548.16 EEA25710.1 - 0.11 11.8 1.6 0.64 9.3 0.1 2.1 2 0 0 2 2 2 0 AIG1 family RRF_GI PF12614.8 EEA25711.1 - 0.0077 16.4 0.6 0.012 15.8 0.6 1.4 1 0 0 1 1 1 1 Ribosome recycling factor SlyX PF04102.12 EEA25711.1 - 0.019 15.6 3.5 0.15 12.7 0.8 2.9 3 0 0 3 3 3 0 SlyX TRAF_BIRC3_bd PF16673.5 EEA25711.1 - 0.043 13.6 1.4 3.4 7.5 0.5 2.7 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain GlutR_dimer PF00745.20 EEA25711.1 - 0.49 10.9 4.7 0.47 10.9 1.1 2.3 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Fungal_trans_2 PF11951.8 EEA25712.1 - 2.5e-10 39.7 0.6 4.7e-09 35.5 0.1 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25712.1 - 9.2e-08 32.1 12.0 1.6e-07 31.4 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA25713.1 - 7e-26 91.0 60.0 4.3e-25 88.4 34.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pyr_redox_2 PF07992.14 EEA25714.1 - 1.9e-45 155.4 0.2 3e-45 154.7 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 EEA25714.1 - 5.7e-22 77.9 0.0 1e-21 77.1 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.27 EEA25714.1 - 1.8e-17 63.6 4.1 5.8e-17 62.0 1.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 EEA25714.1 - 6.4e-16 58.2 0.0 1.8e-15 56.7 0.0 1.9 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 EEA25714.1 - 2e-15 56.5 0.1 7.7e-15 54.6 0.0 2.1 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Fer2_BFD PF04324.15 EEA25714.1 - 3.9e-15 55.9 8.0 3.8e-12 46.3 5.7 2.8 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain NIR_SIR_ferr PF03460.17 EEA25714.1 - 5.6e-09 35.7 0.0 1.4e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rubredoxin_C PF18267.1 EEA25714.1 - 1.4e-05 24.9 3.3 0.045 13.7 0.2 3.8 4 0 0 4 4 4 2 Rubredoxin NAD+ reductase C-terminal domain NAD_binding_9 PF13454.6 EEA25714.1 - 0.0033 17.4 0.1 3.2 7.7 0.0 3.6 3 1 1 4 4 4 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EEA25714.1 - 0.088 11.5 0.0 3.3 6.3 0.0 2.4 2 0 0 2 2 2 0 HI0933-like protein Mo-co_dimer PF03404.16 EEA25715.1 - 6.4e-60 201.1 0.0 1.3e-59 200.1 0.0 1.6 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 EEA25715.1 - 2.3e-53 180.3 0.0 4e-53 179.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.24 EEA25715.1 - 4.4e-32 110.4 0.0 7.5e-32 109.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EEA25715.1 - 1.5e-31 109.3 0.0 3.4e-31 108.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EEA25715.1 - 2.7e-18 65.8 0.0 6e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EEA25715.1 - 0.0092 16.1 0.0 0.046 13.8 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain GCP_C_terminal PF04130.13 EEA25716.1 - 3.3e-70 237.0 0.0 5e-70 236.4 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EEA25716.1 - 5.6e-46 157.6 0.1 9.1e-46 156.9 0.1 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Eaf7 PF07904.13 EEA25717.1 - 3.1e-29 101.4 0.0 3.1e-29 101.4 0.0 2.1 2 0 0 2 2 2 1 Chromatin modification-related protein EAF7 Iso_dh PF00180.20 EEA25718.1 - 7.2e-101 337.8 0.0 8.7e-101 337.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HHH_2 PF12826.7 EEA25718.1 - 0.036 14.2 0.1 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif Phage_30_3 PF08010.11 EEA25718.1 - 0.046 13.5 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 Sec5 PF15469.6 EEA25719.1 - 2e-37 128.9 0.0 7.1e-37 127.1 0.0 2.0 2 0 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.11 EEA25719.1 - 1e-05 25.5 0.0 4.2e-05 23.6 0.0 2.1 1 0 0 1 1 1 1 Vps51/Vps67 rRNA_processing PF08524.11 EEA25720.1 - 0.0094 16.0 24.6 0.09 12.8 24.6 2.2 1 1 0 1 1 1 1 rRNA processing DUF4210 PF13915.6 EEA25721.1 - 7.9e-33 112.9 0.4 3.4e-32 110.8 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 EEA25721.1 - 8.8e-25 86.6 0.3 2e-24 85.5 0.3 1.7 1 0 0 1 1 1 1 Chromosome segregation during meiosis CAP_N PF01213.19 EEA25722.1 - 1.6e-114 382.6 0.3 1.6e-114 382.6 0.3 1.4 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EEA25722.1 - 5.1e-55 185.4 1.9 7.6e-55 184.8 1.9 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal DEC-1_N PF04625.13 EEA25722.1 - 0.03 13.3 21.7 0.48 9.4 13.4 2.2 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region PfkB PF00294.24 EEA25723.1 - 2.2e-11 43.6 0.0 3.1e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase dsrm PF00035.26 EEA25725.1 - 4.6e-07 30.5 0.0 9.6e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 EEA25725.1 - 6.7e-06 26.7 0.0 3.2e-05 24.5 0.0 2.2 2 1 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EEA25725.1 - 7.6e-05 22.9 0.0 0.0036 17.4 0.0 2.3 2 0 0 2 2 2 1 Ribonuclease-III-like Phage_portal_2 PF05136.13 EEA25725.1 - 0.1 11.7 0.1 1.1 8.3 0.1 2.1 2 0 0 2 2 2 0 Phage portal protein, lambda family BSP PF04450.12 EEA25726.1 - 3.4e-73 245.9 0.0 4e-73 245.6 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria Peptidase_M91 PF14891.6 EEA25726.1 - 0.042 14.2 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 Effector protein Peptidase_M76 PF09768.9 EEA25726.1 - 0.16 11.7 0.1 0.24 11.2 0.1 1.2 1 0 0 1 1 1 0 Peptidase M76 family CLASP_N PF12348.8 EEA25727.1 - 1.1e-156 519.1 0.2 9.8e-92 306.6 0.0 2.3 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 EEA25727.1 - 2.8e-05 24.0 0.1 7.9 7.0 0.0 5.1 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EEA25727.1 - 0.00098 19.2 0.0 0.6 10.1 0.0 3.4 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EEA25727.1 - 0.041 13.8 0.1 0.12 12.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) UME PF08064.13 EEA25727.1 - 0.16 11.9 0.2 1.5 8.8 0.0 2.6 3 0 0 3 3 3 0 UME (NUC010) domain RhoGAP PF00620.27 EEA25728.1 - 5.3e-48 162.7 0.0 2.1e-47 160.8 0.0 2.0 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EEA25728.1 - 8.2e-14 51.6 18.6 4e-09 36.6 2.7 2.4 2 0 0 2 2 2 2 LIM domain NAP PF00956.18 EEA25728.1 - 0.013 14.6 1.3 0.058 12.6 0.7 2.2 2 0 0 2 2 2 0 Nucleosome assembly protein (NAP) CENP-O PF09496.10 EEA25728.1 - 0.014 15.4 5.9 0.82 9.6 0.5 2.5 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component CENP-H PF05837.12 EEA25728.1 - 0.25 11.8 13.0 0.025 15.0 2.9 3.0 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Fez1 PF06818.15 EEA25728.1 - 0.53 10.7 18.2 1.1 9.7 13.4 2.7 1 1 1 2 2 2 0 Fez1 TF_Zn_Ribbon PF08271.12 EEA25728.1 - 2.4 7.7 15.4 1.8 8.2 1.1 4.4 3 1 1 4 4 4 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EEA25728.1 - 7.8 6.7 20.3 0.93 9.7 1.5 4.1 3 1 2 5 5 5 0 Zinc ribbon domain DASH_Ask1 PF08655.10 EEA25729.1 - 4.8e-31 106.4 0.1 7.8e-31 105.8 0.1 1.3 1 0 0 1 1 1 1 DASH complex subunit Ask1 MoCF_biosynth PF00994.24 EEA25729.1 - 0.043 13.5 0.0 0.082 12.6 0.0 1.4 1 0 0 1 1 1 0 Probable molybdopterin binding domain Abhydrolase_6 PF12697.7 EEA25732.1 - 1.2e-16 62.0 0.0 1.4e-16 61.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA25732.1 - 5.8e-13 49.1 0.0 1.3e-10 41.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA25732.1 - 1.1e-07 31.4 0.0 7.9e-07 28.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EEA25732.1 - 2.6e-06 26.3 0.0 3.6e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Ndr family LicD PF04991.13 EEA25733.1 - 1e-21 78.2 5.5 1.3e-14 54.9 1.1 2.1 1 1 1 2 2 2 2 LicD family WLM PF08325.10 EEA25734.1 - 3.1e-50 170.9 0.0 5.8e-50 170.0 0.0 1.4 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 EEA25734.1 - 7.5e-05 22.9 0.3 0.00014 22.0 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 SprT-like PF10263.9 EEA25734.1 - 0.0051 16.6 0.1 0.0087 15.9 0.1 1.4 1 0 0 1 1 1 1 SprT-like family Thiolase_N PF00108.23 EEA25735.1 - 3.7e-69 233.0 0.2 8.4e-69 231.8 0.0 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA25735.1 - 1.4e-41 141.0 0.2 1.4e-41 141.0 0.2 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EEA25735.1 - 0.00013 21.7 1.2 0.0013 18.3 0.8 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EEA25735.1 - 0.018 14.9 0.6 2.3 8.1 0.2 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III HSP70 PF00012.20 EEA25736.1 - 2e-170 567.9 1.2 3.1e-170 567.3 1.2 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA25736.1 - 9.5e-11 41.1 0.1 2.1e-10 40.0 0.0 1.5 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EEA25736.1 - 0.0055 17.1 0.3 3.8 8.0 0.0 3.2 2 2 0 2 2 2 2 Cell division protein FtsA FGGY_C PF02782.16 EEA25736.1 - 0.027 14.2 0.1 0.071 12.8 0.0 1.7 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Ketoacyl-synt_C PF02801.22 EEA25736.1 - 0.032 14.3 0.1 0.2 11.7 0.0 2.3 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Chitin_synth_2 PF03142.15 EEA25737.1 - 9e-23 80.7 4.0 1.9e-21 76.3 3.8 2.3 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EEA25737.1 - 5.7e-12 46.0 9.6 5.7e-12 46.0 9.6 2.7 2 2 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EEA25737.1 - 6.9e-11 42.5 0.0 1.2e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EEA25737.1 - 0.0028 17.5 0.0 3.3 7.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 La PF05383.17 EEA25738.1 - 4.2e-20 71.5 0.0 7.3e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EEA25738.1 - 4.2e-07 29.7 0.3 9.7e-07 28.5 0.3 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dabb PF07876.12 EEA25739.1 - 1.9e-10 41.2 0.0 2.1e-10 41.1 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain FSH1 PF03959.13 EEA25740.1 - 8.9e-26 90.9 0.0 1.3e-25 90.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) ketoacyl-synt PF00109.26 EEA25741.1 - 7.7e-69 232.1 0.0 1.3e-68 231.3 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA25741.1 - 2.1e-60 203.7 0.5 1.3e-59 201.1 0.0 2.5 3 0 0 3 3 2 1 KR domain Acyl_transf_1 PF00698.21 EEA25741.1 - 7.9e-41 140.6 0.4 1.3e-40 139.9 0.4 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA25741.1 - 3.8e-36 123.7 0.1 8e-36 122.6 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EEA25741.1 - 5.6e-32 111.2 0.0 9.2e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 EEA25741.1 - 1.1e-21 77.5 0.0 2.4e-21 76.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA25741.1 - 3.9e-15 56.3 0.0 1.7e-14 54.3 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA25741.1 - 2.9e-14 53.5 0.0 8e-14 52.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA25741.1 - 1.1e-13 51.3 0.0 3.1e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA25741.1 - 2.6e-13 50.1 0.0 6.4e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EEA25741.1 - 5.2e-10 39.1 0.0 1.3e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase KAsynt_C_assoc PF16197.5 EEA25741.1 - 2.2e-09 37.8 0.0 7.3e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Ubie_methyltran PF01209.18 EEA25741.1 - 1.2e-08 34.6 0.0 3.2e-08 33.2 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.25 EEA25741.1 - 1.4e-07 31.7 0.0 3.4e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_28 PF02636.17 EEA25741.1 - 0.00066 19.4 0.0 0.0015 18.2 0.0 1.5 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Thiolase_N PF00108.23 EEA25741.1 - 0.002 17.6 0.1 0.0039 16.6 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_16 PF10294.9 EEA25741.1 - 0.0038 17.0 0.0 0.008 15.9 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_33 PF10017.9 EEA25741.1 - 0.01 15.0 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_24 PF13578.6 EEA25741.1 - 0.02 15.9 0.0 0.16 13.0 0.0 2.6 3 0 0 3 3 1 0 Methyltransferase domain Abhydrolase_6 PF12697.7 EEA25741.1 - 0.028 15.0 0.1 0.25 11.9 0.0 2.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family FtsJ PF01728.19 EEA25741.1 - 0.05 13.7 0.0 0.67 10.1 0.0 2.6 2 0 0 2 2 2 0 FtsJ-like methyltransferase Alpha-amylase_C PF02806.18 EEA25742.1 - 7.1e-29 100.1 0.0 1.5e-28 99.1 0.0 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EEA25742.1 - 9.5e-19 67.6 0.1 2.3e-18 66.3 0.1 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 EEA25742.1 - 2.8e-16 60.0 0.1 6.1e-12 45.7 0.1 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EEA25742.1 - 0.16 11.0 0.1 0.39 9.7 0.1 1.6 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain AA_permease PF00324.21 EEA25743.1 - 7.6e-118 394.1 43.8 9.2e-118 393.8 43.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA25743.1 - 1e-29 103.6 46.1 1.3e-29 103.3 46.1 1.0 1 0 0 1 1 1 1 Amino acid permease JmjC PF02373.22 EEA25744.1 - 4.5e-37 127.0 1.1 7.6e-37 126.2 0.4 1.8 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 EEA25744.1 - 6.6e-19 68.1 2.7 1.2e-18 67.2 2.7 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EEA25744.1 - 8.6e-19 67.6 2.8 1.9e-18 66.5 2.8 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain JmjN PF02375.17 EEA25744.1 - 1.5e-15 56.8 0.6 4e-15 55.5 0.6 1.8 1 0 0 1 1 1 1 jmjN domain AA_permease_2 PF13520.6 EEA25745.1 - 1.6e-61 208.4 54.6 2e-61 208.1 54.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA25745.1 - 5.9e-33 114.2 49.3 7.8e-33 113.8 49.3 1.0 1 0 0 1 1 1 1 Amino acid permease Cyclase PF04199.13 EEA25746.1 - 7.1e-08 32.8 0.0 1.5e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Putative cyclase Pep1_7 PF17232.2 EEA25747.1 - 9 6.8 7.7 3.8 8.1 2.1 2.7 2 0 0 2 2 2 0 Elicitor peptide 1-7 Velvet PF11754.8 EEA25748.1 - 2.5e-51 175.1 0.0 1.1e-31 110.6 0.0 3.8 2 2 1 3 3 3 2 Velvet factor Rad51 PF08423.11 EEA25749.1 - 8.1e-45 153.1 0.0 3.3e-41 141.2 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 EEA25749.1 - 5.5e-10 39.1 0.0 9.4e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EEA25749.1 - 2.4e-08 33.6 0.1 2.4e-07 30.4 0.1 2.1 1 1 0 1 1 1 1 KaiC RecA PF00154.21 EEA25749.1 - 9.8e-06 25.2 0.1 0.0014 18.2 0.0 2.2 2 0 0 2 2 2 2 recA bacterial DNA recombination protein DnaB_C PF03796.15 EEA25749.1 - 0.0032 16.9 0.3 0.081 12.2 0.1 2.6 2 1 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EEA25749.1 - 0.013 15.8 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 EEA25749.1 - 0.033 13.6 0.2 0.091 12.2 0.2 1.6 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_24 PF13479.6 EEA25749.1 - 0.094 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain FA_desaturase PF00487.24 EEA25750.1 - 1.8e-22 80.4 22.9 1e-21 78.0 22.9 2.2 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EEA25750.1 - 9.7e-07 29.1 0.0 2.2e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) TRAPPC10 PF12584.8 EEA25752.1 - 2.8e-40 137.6 0.1 4.5e-40 136.9 0.1 1.4 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.8 EEA25752.1 - 0.00094 18.8 1.0 0.0015 18.1 0.1 1.8 2 0 0 2 2 2 1 Foie gras liver health family 1 TIG PF01833.24 EEA25753.1 - 6.9e-10 38.9 1.7 1.4e-09 37.9 0.3 2.4 2 0 0 2 2 2 1 IPT/TIG domain Ank_5 PF13857.6 EEA25753.1 - 7.8e-08 32.4 0.1 0.00059 20.1 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA25753.1 - 1.4e-06 28.8 0.0 2.7e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA25753.1 - 2.3e-05 24.6 2.5 0.23 12.0 0.5 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EEA25753.1 - 6.8e-05 23.4 0.1 0.00049 20.6 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA25753.1 - 0.0014 18.9 0.2 0.89 10.3 0.2 2.8 2 0 0 2 2 2 1 Ankyrin repeat DUF2157 PF09925.9 EEA25753.1 - 0.21 11.4 0.0 0.4 10.5 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Glyco_hydro_61 PF03443.14 EEA25755.1 - 5.2e-69 232.3 0.4 6.9e-69 231.9 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 SUI1 PF01253.22 EEA25756.1 - 2.8e-23 82.2 1.6 2.2e-22 79.3 0.5 2.4 2 0 0 2 2 2 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EEA25756.1 - 2.2e-08 34.7 0.0 1e-06 29.3 0.0 2.7 1 1 0 1 1 1 1 Pre-PUA-like domain Kin17_mid PF10357.9 EEA25756.1 - 0.077 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein Img2 PF05046.14 EEA25756.1 - 0.27 11.5 1.3 0.77 10.1 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) Carn_acyltransf PF00755.20 EEA25757.1 - 5.9e-208 692.2 0.0 8.6e-208 691.7 0.0 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF3439 PF11921.8 EEA25757.1 - 9.1 6.3 6.9 3.7 7.5 2.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Glyco_hydro_92 PF07971.12 EEA25758.1 - 1.2e-138 462.9 2.2 1.5e-138 462.6 2.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EEA25758.1 - 3.8e-46 157.9 5.3 6.7e-46 157.1 5.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain UPF0160 PF03690.13 EEA25759.1 - 1.7e-123 412.3 0.0 1.9e-123 412.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Dicty_CAR PF05462.11 EEA25760.1 - 4.5e-06 26.0 11.1 4.5e-06 26.0 11.1 2.0 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EEA25760.1 - 0.012 14.9 11.3 0.026 13.8 11.3 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 EEA25760.1 - 0.039 13.3 7.7 0.12 11.6 7.8 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Ocular_alb PF02101.15 EEA25760.1 - 0.29 10.0 5.5 0.54 9.1 5.5 1.5 1 0 0 1 1 1 0 Ocular albinism type 1 protein Git3 PF11710.8 EEA25760.1 - 5.9 6.6 21.3 0.62 9.8 16.1 2.0 2 1 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Ras PF00071.22 EEA25761.1 - 3.1e-63 212.2 0.2 3.8e-63 211.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA25761.1 - 2.2e-35 121.5 0.2 3.2e-35 121.0 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA25761.1 - 7.4e-13 48.3 0.1 9.8e-13 47.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA25761.1 - 8.8e-08 32.2 0.1 1.4e-07 31.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA25761.1 - 0.00016 21.6 0.2 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EEA25761.1 - 0.00057 19.3 0.1 0.00094 18.6 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA25761.1 - 0.0006 19.4 0.2 0.003 17.1 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EEA25761.1 - 0.0024 18.2 0.0 0.02 15.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EEA25761.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EEA25761.1 - 0.017 15.2 0.2 0.053 13.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA25761.1 - 0.019 15.4 0.1 0.033 14.6 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EEA25761.1 - 0.022 15.3 0.1 0.031 14.8 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EEA25761.1 - 0.023 14.4 0.1 0.061 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EEA25761.1 - 0.05 13.0 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein FeoB_N PF02421.18 EEA25761.1 - 0.074 12.6 0.1 0.23 11.0 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_7 PF12775.7 EEA25761.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_21 PF13304.6 EEA25761.1 - 0.12 12.1 0.7 0.17 11.7 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SpoIIID PF12116.8 EEA25761.1 - 0.13 12.3 0.1 2.8 8.1 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D Ras PF00071.22 EEA25762.1 - 3.1e-63 212.2 0.2 3.8e-63 211.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA25762.1 - 2.2e-35 121.5 0.2 3.2e-35 121.0 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA25762.1 - 7.4e-13 48.3 0.1 9.8e-13 47.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA25762.1 - 8.8e-08 32.2 0.1 1.4e-07 31.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA25762.1 - 0.00016 21.6 0.2 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EEA25762.1 - 0.00057 19.3 0.1 0.00094 18.6 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA25762.1 - 0.0006 19.4 0.2 0.003 17.1 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EEA25762.1 - 0.0024 18.2 0.0 0.02 15.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EEA25762.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EEA25762.1 - 0.017 15.2 0.2 0.053 13.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA25762.1 - 0.019 15.4 0.1 0.033 14.6 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EEA25762.1 - 0.022 15.3 0.1 0.031 14.8 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EEA25762.1 - 0.023 14.4 0.1 0.061 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EEA25762.1 - 0.05 13.0 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein FeoB_N PF02421.18 EEA25762.1 - 0.074 12.6 0.1 0.23 11.0 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_7 PF12775.7 EEA25762.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_21 PF13304.6 EEA25762.1 - 0.12 12.1 0.7 0.17 11.7 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SpoIIID PF12116.8 EEA25762.1 - 0.13 12.3 0.1 2.8 8.1 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D DDE_3 PF13358.6 EEA25763.1 - 1.4e-28 99.5 0.0 2.4e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA25763.1 - 6.9e-07 29.4 0.0 1.6e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 EEA25763.1 - 0.023 15.3 0.0 0.091 13.4 0.0 2.1 1 1 1 2 2 2 0 Homeodomain-like domain Fas_alpha_ACP PF18325.1 EEA25764.1 - 4.5e-58 196.2 0.2 2.4e-57 193.8 0.1 2.2 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 EEA25764.1 - 1.3e-47 162.1 0.0 2.8e-47 161.0 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 EEA25764.1 - 7.8e-22 78.1 0.0 2.6e-21 76.4 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EEA25764.1 - 3.2e-11 43.3 0.0 3.1e-10 40.1 0.0 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EEA25764.1 - 5.9e-07 29.1 0.0 1.9e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase DUF1729 PF08354.10 EEA25765.1 - 1.8e-139 464.6 0.0 2.9e-139 463.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EEA25765.1 - 4.6e-63 213.7 0.0 8.9e-60 202.8 0.0 3.2 3 0 0 3 3 3 2 Acyl transferase domain FAS_meander PF17951.1 EEA25765.1 - 1.7e-40 138.2 0.0 4e-40 137.0 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 EEA25765.1 - 1.2e-31 110.3 0.1 5.6e-31 108.1 0.0 2.0 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 EEA25765.1 - 6.1e-31 106.5 0.2 1.9e-30 105.0 0.0 1.8 2 0 0 2 2 2 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EEA25765.1 - 9.8e-26 90.4 0.0 2.8e-25 89.0 0.0 1.9 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 EEA25765.1 - 6.9e-11 42.3 0.0 1.5e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta Ank_2 PF12796.7 EEA25766.1 - 8.7e-20 71.1 0.6 4e-19 69.0 0.8 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA25766.1 - 1.9e-18 66.5 0.3 1.3e-10 41.6 0.2 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA25766.1 - 3.7e-18 65.1 3.1 3.5e-06 27.2 0.6 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EEA25766.1 - 4e-16 58.9 4.1 4.6e-08 33.2 0.5 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA25766.1 - 4.9e-15 54.1 0.4 0.00032 20.9 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeat bZIP_1 PF00170.21 EEA25766.1 - 0.18 11.9 5.2 0.39 10.8 5.2 1.6 1 0 0 1 1 1 0 bZIP transcription factor FAD_binding_3 PF01494.19 EEA25767.1 - 8.1e-75 252.2 0.0 1.1e-74 251.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EEA25767.1 - 1.6e-05 25.0 0.0 3.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_2 PF00890.24 EEA25767.1 - 5.5e-05 22.4 0.1 0.00059 19.0 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EEA25767.1 - 8.4e-05 22.3 0.5 0.0016 18.1 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EEA25767.1 - 0.00095 18.6 0.4 0.0021 17.5 0.2 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA25767.1 - 0.0092 15.2 0.0 0.029 13.6 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA25767.1 - 0.048 12.9 0.0 0.09 12.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA25767.1 - 0.057 12.1 0.1 0.092 11.4 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 EEA25767.1 - 0.17 11.1 0.1 0.3 10.3 0.1 1.3 1 0 0 1 1 1 0 Thi4 family p450 PF00067.22 EEA25768.1 - 9.5e-61 205.9 0.0 1.2e-60 205.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Chisel PF15355.6 EEA25768.1 - 0.098 12.9 0.0 10 6.4 0.0 2.5 2 0 0 2 2 2 0 Stretch-responsive small skeletal muscle X protein, Chisel SnoaL_3 PF13474.6 EEA25768.1 - 0.15 12.3 0.0 2.1 8.7 0.0 2.3 2 0 0 2 2 2 0 SnoaL-like domain Acyl-CoA_dh_1 PF00441.24 EEA25769.1 - 1.2e-17 64.5 1.2 4.5e-17 62.6 1.2 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EEA25769.1 - 1.3e-12 47.8 0.0 4.9e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain AidB_N PF18158.1 EEA25769.1 - 4.4e-09 36.5 0.0 7.8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_2 PF08028.11 EEA25769.1 - 0.0097 16.2 2.2 0.0097 16.2 2.2 2.0 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain AcylCoA_dehyd_C PF12186.8 EEA25769.1 - 0.12 12.5 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal PYC_OADA PF02436.18 EEA25769.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Conserved carboxylase domain NAD_binding_1 PF00175.21 EEA25770.1 - 3e-33 114.7 0.0 4.6e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EEA25770.1 - 2.8e-27 95.0 0.0 5.1e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 EEA25770.1 - 7.2e-19 67.7 0.2 1.6e-18 66.6 0.2 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EEA25770.1 - 3.4e-08 33.8 0.0 0.00025 21.2 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain DUF829 PF05705.14 EEA25771.1 - 1.6e-43 149.3 0.0 2.1e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) MFS_1 PF07690.16 EEA25772.1 - 1e-30 106.9 51.5 1.5e-30 106.4 48.8 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EEA25772.1 - 0.0015 16.9 0.8 0.0015 16.9 0.8 2.0 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Neurensin PF14927.6 EEA25772.1 - 0.11 12.2 0.0 30 4.3 0.0 3.0 2 0 0 2 2 2 0 Neurensin Zn_clus PF00172.18 EEA25773.1 - 0.1 12.7 5.9 0.32 11.1 1.7 2.3 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Chromo PF00385.24 EEA25774.1 - 1.1e-08 34.8 2.4 2.3e-08 33.8 2.4 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_2 PF07724.14 EEA25775.1 - 1.5e-38 132.6 0.0 1.6e-37 129.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EEA25775.1 - 2.2e-14 54.0 0.0 4.5e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EEA25775.1 - 9.6e-10 38.4 0.1 3.5e-09 36.6 0.0 1.9 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EEA25775.1 - 1.7e-06 28.1 0.0 3.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EEA25775.1 - 0.00041 19.8 0.2 0.018 14.4 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EEA25775.1 - 0.00058 19.6 0.0 0.079 12.7 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 EEA25775.1 - 0.0015 18.8 0.1 0.018 15.3 0.1 2.5 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 EEA25775.1 - 0.0045 16.1 0.0 0.0093 15.1 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain AAA_16 PF13191.6 EEA25775.1 - 0.0047 17.3 0.1 0.015 15.7 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EEA25775.1 - 0.0048 16.7 0.1 0.044 13.5 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EEA25775.1 - 0.0079 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 EEA25775.1 - 0.012 15.4 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EEA25775.1 - 0.043 13.3 0.0 0.08 12.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 EEA25775.1 - 0.043 13.7 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EEA25775.1 - 0.049 14.0 0.0 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 EEA25775.1 - 0.074 13.2 0.6 1.7 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA25775.1 - 0.13 12.8 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EEA25775.1 - 0.14 12.1 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EEA25775.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain F-box-like PF12937.7 EEA25776.1 - 0.00013 21.8 0.5 0.00013 21.8 0.5 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EEA25776.1 - 0.00026 20.8 1.4 0.00096 19.0 1.4 2.0 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.6 EEA25776.1 - 0.0033 17.4 0.0 0.007 16.3 0.0 1.6 1 1 0 1 1 1 1 F-box-like domain Brix PF04427.18 EEA25777.1 - 3.7e-30 105.5 0.0 4.7e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 Brix domain DNA_pol_phi PF04931.13 EEA25777.1 - 0.097 10.8 5.6 0.13 10.3 5.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Sporozoite_P67 PF05642.11 EEA25777.1 - 9.4 4.2 7.3 1.1 7.3 2.5 1.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen WW PF00397.26 EEA25778.1 - 2e-07 30.9 1.0 4.2e-07 29.9 1.0 1.6 1 0 0 1 1 1 1 WW domain Asp PF00026.23 EEA25779.1 - 9.2e-46 156.7 0.0 1.1e-45 156.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA25779.1 - 0.00014 22.5 0.3 0.61 10.8 0.2 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EEA25779.1 - 0.013 16.0 0.6 5.5 7.6 0.0 3.1 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 EEA25779.1 - 0.058 13.6 0.0 12 6.0 0.0 2.9 2 1 1 3 3 3 0 Xylanase inhibitor N-terminal DUF2169 PF09937.9 EEA25781.1 - 0.059 12.8 0.1 0.072 12.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2169) Abp2 PF09441.10 EEA25782.1 - 2e-83 278.6 0.1 3.9e-83 277.6 0.1 1.5 1 0 0 1 1 1 1 ARS binding protein 2 F-box-like PF12937.7 EEA25783.1 - 0.00015 21.6 0.0 0.0003 20.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like Use1 PF09753.9 EEA25783.1 - 0.23 11.2 7.0 0.078 12.7 3.5 1.9 2 0 0 2 2 2 0 Membrane fusion protein Use1 E2F_TDP PF02319.20 EEA25786.1 - 0.0058 16.7 0.1 0.01 15.9 0.1 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Myb_DNA-binding PF00249.31 EEA25787.1 - 0.0011 19.2 0.0 0.0027 17.9 0.0 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 EEA25787.1 - 0.067 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_6 PF13921.6 EEA25787.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain MSP1_C PF07462.11 EEA25787.1 - 0.47 9.1 1.7 0.48 9.0 1.7 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Glyco_hydro_31 PF01055.26 EEA25789.1 - 2.7e-110 369.6 4.5 3.4e-110 369.3 4.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EEA25789.1 - 7.9e-18 64.5 0.0 5.6e-17 61.8 0.1 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like PAP_assoc PF03828.19 EEA25790.1 - 2.7e-13 49.9 0.1 7e-13 48.6 0.1 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EEA25790.1 - 5.5e-08 33.0 0.0 1.1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Mito_fiss_reg PF05308.11 EEA25790.1 - 6.6 6.7 8.8 0.9 9.6 2.2 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator GFA PF04828.14 EEA25791.1 - 3e-16 59.5 12.5 2.3e-10 40.6 0.9 3.4 3 1 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme PRKCSH-like PF12999.7 EEA25792.1 - 4.5e-48 163.4 7.9 2.2e-28 99.2 0.5 3.0 3 0 0 3 3 3 2 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EEA25792.1 - 3.7e-32 111.1 4.5 4.8e-31 107.5 1.9 2.8 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EEA25792.1 - 4.3e-09 37.2 0.5 1.3e-08 35.7 0.1 2.1 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein ATG16 PF08614.11 EEA25792.1 - 0.0069 16.6 1.9 0.0069 16.6 1.9 3.0 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) ATG27 PF09451.10 EEA25792.1 - 0.011 15.6 1.1 0.024 14.5 1.1 1.5 1 0 0 1 1 1 0 Autophagy-related protein 27 Fib_alpha PF08702.10 EEA25792.1 - 0.15 12.2 5.5 1.8 8.7 0.1 3.0 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Herpes_UL6 PF01763.16 EEA25792.1 - 0.22 10.0 1.2 0.34 9.4 1.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like Rootletin PF15035.6 EEA25792.1 - 0.87 9.6 10.5 0.41 10.7 6.5 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF2203 PF09969.9 EEA25792.1 - 4.4 8.0 7.8 17 6.1 0.2 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Ldl_recept_a PF00057.18 EEA25792.1 - 4.5 7.6 11.0 0.86 9.9 1.3 2.8 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A GTP-bdg_M PF16360.5 EEA25792.1 - 5.3 7.7 10.0 3.1 8.5 6.6 2.4 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region CASP_C PF08172.12 EEA25792.1 - 6.9 5.9 12.6 0.088 12.1 5.2 1.5 2 0 0 2 2 2 0 CASP C terminal DUF4140 PF13600.6 EEA25792.1 - 8.5 6.9 11.8 10 6.6 5.7 3.0 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Rtf2 PF04641.12 EEA25793.1 - 1.9e-64 217.6 4.2 2.3e-64 217.3 4.2 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 EEA25793.1 - 1.5e-06 27.9 0.0 0.07 13.0 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 EEA25793.1 - 0.0074 16.2 0.2 0.013 15.4 0.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA25793.1 - 0.012 15.6 0.1 0.039 14.0 0.1 1.8 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EEA25793.1 - 0.029 14.2 0.2 0.056 13.3 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA25793.1 - 0.11 12.8 0.1 0.25 11.7 0.1 1.6 1 1 0 1 1 1 0 Ring finger domain zf-RING_11 PF17123.5 EEA25793.1 - 0.12 12.1 0.5 0.86 9.4 0.0 2.3 2 0 0 2 2 2 0 RING-like zinc finger RR_TM4-6 PF06459.12 EEA25793.1 - 0.97 9.2 7.7 1.6 8.5 7.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L50 PF10501.9 EEA25794.1 - 3.6e-20 72.1 0.0 7.7e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Ribosomal subunit 39S Methyltransf_25 PF13649.6 EEA25794.1 - 0.066 13.9 0.1 2.6 8.8 0.1 2.5 2 0 0 2 2 2 0 Methyltransferase domain Herpes_LMP2 PF07415.11 EEA25794.1 - 0.82 8.4 1.6 1.1 7.9 1.6 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Thiolase_N PF00108.23 EEA25795.1 - 6.6e-78 261.7 1.3 9.1e-78 261.2 1.3 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA25795.1 - 4.2e-44 149.2 1.3 8.7e-44 148.1 0.7 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EEA25795.1 - 0.014 15.0 0.7 0.052 13.1 0.3 2.1 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain DAHP_synth_1 PF00793.20 EEA25797.1 - 5.5e-100 333.8 0.0 6.8e-100 333.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family COX14 PF14880.6 EEA25798.1 - 8.2e-18 64.0 0.1 8.2e-18 64.0 0.1 2.0 2 0 0 2 2 2 1 Cytochrome oxidase c assembly SPX PF03105.19 EEA25798.1 - 0.24 11.3 8.1 0.4 10.6 8.1 1.3 1 1 0 1 1 1 0 SPX domain DUF3807 PF12720.7 EEA25798.1 - 6.9 6.9 7.6 2.3 8.5 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF2458 PF10454.9 EEA25799.1 - 2.3e-53 180.4 0.4 2.6e-53 180.2 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) MRFAP1 PF15155.6 EEA25799.1 - 0.059 13.9 1.3 0.11 13.0 1.3 1.5 1 0 0 1 1 1 0 MORF4 family-associated protein1 Hexokinase_2 PF03727.16 EEA25800.1 - 2.8e-60 203.7 0.0 4.2e-60 203.1 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EEA25800.1 - 1.3e-46 159.0 0.0 2e-46 158.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Tom37_C PF11801.8 EEA25800.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Tom37 C-terminal domain Glyoxalase PF00903.25 EEA25801.1 - 9.4e-13 48.5 0.0 1.6e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Hva1_TUDOR PF11160.8 EEA25801.1 - 3.3e-07 30.4 0.2 6e-07 29.5 0.2 1.5 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain Glyoxalase_2 PF12681.7 EEA25801.1 - 0.00011 22.1 0.1 0.0046 16.9 0.1 2.7 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 EEA25801.1 - 0.001 19.3 0.0 0.0022 18.3 0.0 1.5 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EEA25801.1 - 0.035 14.9 0.0 0.081 13.7 0.0 1.7 1 1 0 1 1 1 0 Glyoxalase-like domain AAA PF00004.29 EEA25803.1 - 5.3e-53 179.0 0.0 3.5e-43 147.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EEA25803.1 - 2.4e-29 101.6 0.2 5.3e-29 100.5 0.2 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EEA25803.1 - 2.2e-16 59.4 0.1 8.2e-09 35.1 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EEA25803.1 - 2.4e-08 34.6 4.3 0.0021 18.4 0.2 4.1 2 2 1 3 3 3 2 AAA ATPase domain NACHT PF05729.12 EEA25803.1 - 1e-07 32.0 1.6 2e-05 24.5 0.1 3.2 3 0 0 3 3 3 1 NACHT domain AAA_18 PF13238.6 EEA25803.1 - 3.7e-06 27.5 0.0 0.019 15.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EEA25803.1 - 6.3e-06 26.5 2.1 0.053 13.8 0.2 3.8 2 2 1 3 3 3 2 AAA domain TsaE PF02367.17 EEA25803.1 - 8.1e-06 25.8 0.0 0.011 15.7 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 EEA25803.1 - 8.9e-06 25.9 0.0 0.15 12.2 0.0 2.7 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EEA25803.1 - 4.3e-05 23.3 0.0 0.016 15.0 0.0 2.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EEA25803.1 - 0.00025 21.1 0.1 0.62 10.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EEA25803.1 - 0.00026 20.8 0.2 0.19 11.4 0.0 2.6 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_14 PF13173.6 EEA25803.1 - 0.00037 20.5 0.0 0.56 10.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EEA25803.1 - 0.0008 19.7 0.0 0.22 11.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EEA25803.1 - 0.00095 19.7 0.0 0.28 11.7 0.0 2.9 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 EEA25803.1 - 0.00096 18.7 0.0 0.026 14.0 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 EEA25803.1 - 0.003 16.8 0.0 0.57 9.4 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin KAP_NTPase PF07693.14 EEA25803.1 - 0.004 16.4 0.0 0.017 14.4 0.0 1.8 1 1 1 2 2 2 1 KAP family P-loop domain AAA_33 PF13671.6 EEA25803.1 - 0.0065 16.6 0.0 0.25 11.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EEA25803.1 - 0.0068 16.8 0.4 3 8.2 0.1 3.2 3 0 0 3 3 3 1 AAA domain ATPase PF06745.13 EEA25803.1 - 0.0084 15.5 0.1 0.96 8.8 0.0 2.3 2 0 0 2 2 2 1 KaiC Mg_chelatase PF01078.21 EEA25803.1 - 0.01 15.2 0.1 0.95 8.8 0.1 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA25803.1 - 0.011 16.1 0.0 9.7 6.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Viral_helicase1 PF01443.18 EEA25803.1 - 0.014 15.1 0.0 0.57 9.9 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EEA25803.1 - 0.02 14.8 0.0 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 EEA25803.1 - 0.023 14.4 0.1 0.32 10.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 EEA25803.1 - 0.025 14.2 4.3 9 5.8 0.2 3.8 2 2 2 4 4 4 0 AAA domain TIP49 PF06068.13 EEA25803.1 - 0.036 13.3 0.0 1.9 7.6 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain PEX-2N PF09263.10 EEA25803.1 - 0.047 14.0 0.1 2 8.8 0.0 2.7 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal ATPase_2 PF01637.18 EEA25803.1 - 0.1 12.5 0.0 2.8 7.8 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EEA25803.1 - 0.11 12.9 0.1 0.99 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EEA25803.1 - 0.28 10.8 1.8 2.1 7.9 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MCM PF00493.23 EEA25804.1 - 2.3e-103 344.1 0.0 3.8e-103 343.4 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA25804.1 - 3.1e-33 114.3 0.2 5.6e-33 113.5 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 EEA25804.1 - 3.2e-22 79.1 0.9 8.5e-22 77.7 0.9 1.8 1 0 0 1 1 1 1 MCM N-terminal domain MCM_lid PF17855.1 EEA25804.1 - 2.1e-20 72.9 0.2 5.4e-20 71.6 0.2 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EEA25804.1 - 3.1e-07 30.0 0.0 2e-05 24.0 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EEA25804.1 - 1.2e-06 28.6 0.0 4.2e-06 26.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 EEA25804.1 - 0.0031 17.3 0.0 0.0089 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 EEA25804.1 - 0.026 14.4 0.0 0.084 12.7 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EEA25804.1 - 0.16 11.6 0.0 0.79 9.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AMP-binding PF00501.28 EEA25805.1 - 4.6e-99 331.9 0.0 5.4e-99 331.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA25805.1 - 7.4e-10 39.7 0.5 1.6e-09 38.6 0.5 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Phage_capsid PF05065.13 EEA25805.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Phage capsid family Fungal_trans_2 PF11951.8 EEA25806.1 - 9.6e-56 189.2 7.5 1.5e-55 188.6 7.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25806.1 - 2.1e-08 34.2 11.2 4.9e-08 33.0 11.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.20 EEA25807.1 - 2.3e-163 543.9 0.1 2.8e-163 543.6 0.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EEA25807.1 - 8.6e-06 25.9 0.1 1.9e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EEA25807.1 - 0.00024 21.4 0.0 0.00049 20.5 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain CMAS PF02353.20 EEA25808.1 - 4.2e-62 209.9 0.1 5.4e-62 209.6 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EEA25808.1 - 1.6e-07 32.0 0.0 3.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA25808.1 - 4e-07 30.0 0.0 6.4e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA25808.1 - 8.1e-07 29.6 0.0 1.8e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EEA25808.1 - 0.00048 19.7 0.0 0.00081 19.0 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 EEA25808.1 - 0.018 15.8 0.0 0.041 14.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EEA25808.1 - 0.066 12.8 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 EEA25808.1 - 0.099 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Tropomyosin_1 PF12718.7 EEA25810.1 - 4.3e-52 176.1 32.4 5.1e-52 175.8 32.4 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EEA25810.1 - 1.3e-09 37.8 30.9 4.6e-05 22.9 16.3 2.6 1 1 1 2 2 2 2 Tropomyosin KLRAQ PF10205.9 EEA25810.1 - 0.0002 21.5 22.6 0.00064 19.9 10.6 2.9 1 1 1 2 2 2 1 Predicted coiled-coil domain-containing protein DUF4407 PF14362.6 EEA25810.1 - 0.0012 18.3 21.8 0.0014 18.0 15.2 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) GAS PF13851.6 EEA25810.1 - 0.0029 17.0 30.7 0.011 15.1 21.0 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding DUF724 PF05266.14 EEA25810.1 - 0.0076 16.1 22.8 0.033 14.0 8.4 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF724) Spc7 PF08317.11 EEA25810.1 - 0.011 14.7 31.9 0.2 10.5 11.4 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 EEA25810.1 - 0.011 15.8 27.3 0.2 11.8 0.3 4.4 2 1 3 5 5 5 0 bZIP transcription factor ATG16 PF08614.11 EEA25810.1 - 0.012 15.8 31.8 1.1 9.4 20.0 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 EEA25810.1 - 0.027 14.8 21.0 0.083 13.2 0.8 3.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ERM PF00769.19 EEA25810.1 - 0.028 14.2 35.7 0.028 14.2 15.2 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family SOGA PF11365.8 EEA25810.1 - 0.037 15.1 23.7 0.97 10.6 1.5 3.4 2 1 1 3 3 3 0 Protein SOGA ADIP PF11559.8 EEA25810.1 - 0.038 14.1 29.4 1.2 9.2 8.4 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Qua1 PF16274.5 EEA25810.1 - 0.038 13.8 0.4 0.038 13.8 0.4 2.8 2 1 1 3 3 2 0 Qua1 domain DUF1664 PF07889.12 EEA25810.1 - 0.055 13.5 14.9 0.42 10.7 4.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 EEA25810.1 - 0.055 14.0 38.2 0.091 13.3 21.6 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region XhlA PF10779.9 EEA25810.1 - 0.059 13.6 24.8 0.14 12.4 2.4 4.0 1 1 3 4 4 4 0 Haemolysin XhlA TACC_C PF05010.14 EEA25810.1 - 0.066 13.0 26.7 0.82 9.4 19.4 2.7 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal EzrA PF06160.12 EEA25810.1 - 0.076 11.2 24.1 0.11 10.6 8.4 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF4200 PF13863.6 EEA25810.1 - 0.082 13.3 31.9 0.38 11.2 14.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) MAD PF05557.13 EEA25810.1 - 0.097 11.0 29.0 0.13 10.6 29.0 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Jnk-SapK_ap_N PF09744.9 EEA25810.1 - 0.12 12.6 31.3 0.12 12.6 19.2 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 VGPC1_C PF16799.5 EEA25810.1 - 0.12 12.3 7.0 0.82 9.7 2.4 2.9 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 BST2 PF16716.5 EEA25810.1 - 0.13 12.9 26.9 0.22 12.2 8.8 3.7 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 MS_channel PF00924.18 EEA25810.1 - 0.19 11.3 1.5 0.24 10.9 1.2 1.2 1 1 0 1 1 1 0 Mechanosensitive ion channel FlaC_arch PF05377.11 EEA25810.1 - 0.19 12.2 20.3 0.36 11.3 1.1 4.3 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) Uso1_p115_C PF04871.13 EEA25810.1 - 0.21 11.9 32.8 0.95 9.8 12.8 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-F_leu_zip PF10473.9 EEA25810.1 - 0.23 11.5 31.5 0.41 10.7 10.3 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EEA25810.1 - 0.23 11.5 35.4 0.072 13.2 10.1 2.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Taxilin PF09728.9 EEA25810.1 - 0.25 10.5 28.7 1 8.5 7.2 2.1 1 1 1 2 2 2 0 Myosin-like coiled-coil protein KASH_CCD PF14662.6 EEA25810.1 - 0.27 11.1 31.1 3.1 7.6 18.5 2.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TMF_TATA_bd PF12325.8 EEA25810.1 - 0.29 11.4 25.7 0.28 11.4 16.1 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 EEA25810.1 - 0.38 10.8 29.7 1.6 8.8 13.3 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 EEA25810.1 - 0.41 11.3 23.4 2.9 8.6 3.7 4.0 1 1 3 4 4 4 0 SlyX Fmp27_WPPW PF10359.9 EEA25810.1 - 0.45 9.3 23.7 0.17 10.7 9.2 2.1 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain FPP PF05911.11 EEA25810.1 - 0.5 8.5 26.7 0.19 9.9 12.2 1.9 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil FapA PF03961.13 EEA25810.1 - 0.61 8.6 25.9 0.52 8.9 9.2 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A Fez1 PF06818.15 EEA25810.1 - 0.65 10.4 25.3 7.6 6.9 25.1 1.9 1 1 0 1 1 1 0 Fez1 DUF4201 PF13870.6 EEA25810.1 - 0.66 9.7 27.3 15 5.3 18.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) ZapB PF06005.12 EEA25810.1 - 0.68 10.4 37.9 1.7 9.2 10.1 4.1 1 1 3 4 4 4 0 Cell division protein ZapB Lebercilin PF15619.6 EEA25810.1 - 0.72 9.5 31.1 7.8 6.1 8.7 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF3450 PF11932.8 EEA25810.1 - 0.72 9.1 28.6 0.95 8.7 7.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Striatin PF08232.12 EEA25810.1 - 0.75 10.4 23.0 6.5 7.3 0.4 2.2 1 1 1 2 2 2 0 Striatin family Phage_GPO PF05929.11 EEA25810.1 - 1.4 8.5 19.8 0.62 9.6 14.7 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase FAM76 PF16046.5 EEA25810.1 - 1.5 8.1 21.4 1.9 7.8 6.6 2.1 1 1 1 2 2 2 0 FAM76 protein Prefoldin_2 PF01920.20 EEA25810.1 - 1.9 8.5 31.7 2.3 8.2 1.0 4.1 2 1 2 4 4 4 0 Prefoldin subunit OmpH PF03938.14 EEA25810.1 - 2.2 8.6 32.0 1.8 8.9 17.8 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Laminin_II PF06009.12 EEA25810.1 - 2.3 8.2 18.3 0.43 10.6 7.3 2.2 1 1 1 2 2 2 0 Laminin Domain II CALCOCO1 PF07888.11 EEA25810.1 - 2.6 6.8 29.5 4.8 5.9 9.1 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4795 PF16043.5 EEA25810.1 - 3.4 7.2 25.0 63 3.1 24.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) PRKG1_interact PF15898.5 EEA25810.1 - 3.5 8.6 28.1 10 7.1 20.5 2.9 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain FUSC PF04632.12 EEA25810.1 - 3.8 5.9 7.9 4.3 5.8 7.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family bZIP_2 PF07716.15 EEA25810.1 - 4.1 7.6 37.9 2.1 8.5 1.0 5.8 2 2 4 6 6 6 0 Basic region leucine zipper DUF2203 PF09969.9 EEA25810.1 - 4.6 8.0 18.8 9.3 7.0 5.8 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Atg14 PF10186.9 EEA25810.1 - 4.9 6.1 22.5 98 1.9 22.1 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5595 PF18077.1 EEA25810.1 - 5.5 7.2 20.9 1.8 8.7 4.3 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF5595) HMMR_N PF15905.5 EEA25810.1 - 6 6.2 31.1 23 4.3 31.1 1.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal TMF_DNA_bd PF12329.8 EEA25810.1 - 6.4 6.9 35.3 2.8 8.0 12.5 3.5 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF1640 PF07798.11 EEA25810.1 - 7.1 6.6 24.0 4.1e+02 0.9 24.0 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) DUF465 PF04325.13 EEA25810.1 - 7.3 6.7 16.5 1.1 9.3 0.2 3.9 4 2 0 4 4 2 0 Protein of unknown function (DUF465) YabA PF06156.13 EEA25810.1 - 7.6 7.2 25.0 1.8e+04 -4.8 24.5 3.2 1 1 0 1 1 0 0 Initiation control protein YabA AAA_13 PF13166.6 EEA25810.1 - 8.5 4.9 23.4 19 3.8 23.4 1.6 1 1 0 1 1 1 0 AAA domain DUF812 PF05667.11 EEA25810.1 - 8.7 5.1 28.6 8.6 5.1 9.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF2730 PF10805.8 EEA25810.1 - 9.2 6.4 16.8 1.5 8.9 3.1 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Mod_r PF07200.13 EEA25810.1 - 9.2 6.4 27.9 3.1 7.9 19.3 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TMPIT PF07851.13 EEA25810.1 - 9.3 5.4 20.8 4.1 6.6 3.4 2.0 1 1 1 2 2 2 0 TMPIT-like protein SpecificRecomb PF10136.9 EEA25810.1 - 9.4 4.4 10.5 10 4.3 10.5 1.1 1 0 0 1 1 1 0 Site-specific recombinase Nop25 PF09805.9 EEA25811.1 - 3.1e-39 134.6 16.3 3.1e-39 134.6 16.3 2.8 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) Leucyl-specific PF14795.6 EEA25811.1 - 0.11 12.5 0.1 0.11 12.5 0.1 2.1 2 1 1 3 3 3 0 Leucine-tRNA synthetase-specific domain ATP-synt_S1 PF05827.12 EEA25812.1 - 0.00031 20.6 0.6 0.00054 19.8 0.6 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF3439 PF11921.8 EEA25814.1 - 0.0038 17.2 7.6 0.0081 16.1 7.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) MBR1 PF17058.5 EEA25814.1 - 5.7 7.2 10.6 1.7 8.9 4.9 2.0 2 0 0 2 2 2 0 Mitochondrial biogenesis regulation protein 1 EXS PF03124.14 EEA25815.1 - 6.8e-109 364.2 7.4 7.7e-109 364.0 7.4 1.0 1 0 0 1 1 1 1 EXS family Pex2_Pex12 PF04757.14 EEA25816.1 - 7.3e-43 146.7 4.4 9.7e-43 146.3 4.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EEA25816.1 - 2.2e-11 43.4 9.8 3.9e-11 42.6 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA25816.1 - 2.9e-11 43.5 10.7 4.6e-11 42.9 10.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EEA25816.1 - 7.1e-11 41.8 7.8 1.2e-10 41.1 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA25816.1 - 8.5e-10 38.3 7.3 1.3e-09 37.7 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA25816.1 - 1.2e-09 38.0 4.7 1.2e-09 38.0 4.7 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA25816.1 - 6.9e-08 32.3 6.8 1.1e-07 31.6 6.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA25816.1 - 4.8e-07 29.5 7.1 8.1e-07 28.8 7.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EEA25816.1 - 1.1e-06 28.8 8.8 2.2e-06 27.8 8.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EEA25816.1 - 4.9e-06 26.6 8.9 1.1e-05 25.5 8.9 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EEA25816.1 - 0.0046 17.1 6.4 0.0084 16.2 6.4 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-Nse PF11789.8 EEA25816.1 - 0.0087 15.9 4.8 0.022 14.6 4.8 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 EEA25816.1 - 0.0093 15.8 1.8 0.066 13.1 2.8 1.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EEA25816.1 - 0.011 15.7 2.7 0.024 14.7 2.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Dzip-like_N PF13815.6 EEA25816.1 - 0.12 12.3 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Rtf2 PF04641.12 EEA25816.1 - 0.33 10.3 0.7 0.72 9.2 0.2 1.9 1 1 0 1 1 1 0 Rtf2 RING-finger zf-RING_4 PF14570.6 EEA25816.1 - 0.35 10.7 9.1 0.9 9.4 8.9 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FYVE PF01363.21 EEA25816.1 - 0.73 10.0 6.2 2.3 8.4 6.2 1.8 1 1 0 1 1 1 0 FYVE zinc finger zf-RING_11 PF17123.5 EEA25816.1 - 3.4 7.5 8.1 0.62 9.9 4.2 1.9 2 0 0 2 2 1 0 RING-like zinc finger IBR PF01485.21 EEA25816.1 - 6.8 7.0 8.3 23 5.3 8.3 1.9 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain DNA_pol_A_exo1 PF01612.20 EEA25817.1 - 2.5e-15 56.6 0.1 5.8e-15 55.4 0.1 1.7 1 0 0 1 1 1 1 3'-5' exonuclease YkyA PF10368.9 EEA25817.1 - 0.23 11.1 4.6 0.63 9.7 4.6 1.7 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein tRNA-synt_1c PF00749.21 EEA25817.1 - 3.2 6.6 7.5 0.81 8.5 0.0 2.8 2 1 1 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain LSM PF01423.22 EEA25818.1 - 1.4e-21 76.0 0.1 1.5e-21 75.8 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA25818.1 - 0.0071 16.5 0.0 0.0085 16.2 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain AA_permease PF00324.21 EEA25819.1 - 5.3e-152 506.8 42.6 6e-152 506.6 42.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA25819.1 - 3.8e-35 121.5 44.6 4.7e-35 121.2 44.6 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EEA25819.1 - 0.0032 16.3 0.9 0.007 15.2 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4781) RhoGAP PF00620.27 EEA25820.1 - 1.5e-16 60.6 0.1 3e-16 59.6 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 EEA25820.1 - 3e-12 46.4 0.0 7.5e-12 45.1 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EEA25820.1 - 7.1e-07 29.4 0.0 2.3e-06 27.8 0.0 2.0 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain adh_short PF00106.25 EEA25821.1 - 5.2e-26 91.3 0.4 7e-26 90.9 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25821.1 - 2.2e-16 60.1 0.7 2.9e-16 59.7 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EEA25821.1 - 4e-06 26.5 0.3 6.4e-05 22.5 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EEA25821.1 - 6.2e-06 26.2 0.4 1.1e-05 25.4 0.1 1.6 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 EEA25821.1 - 0.0053 16.7 0.4 0.007 16.3 0.4 1.4 1 1 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 EEA25821.1 - 0.036 14.3 0.1 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Fungal_trans_2 PF11951.8 EEA25822.1 - 3.8e-26 91.8 6.1 1.4e-25 89.9 6.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain GST_N_2 PF13409.6 EEA25822.1 - 0.0024 18.1 0.1 0.0083 16.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain MACPF PF01823.19 EEA25823.1 - 1.6e-16 61.1 1.0 1.6e-16 61.1 1.0 1.7 2 0 0 2 2 2 1 MAC/Perforin domain PNP_UDP_1 PF01048.20 EEA25824.1 - 8.1e-15 54.7 0.0 1.9e-14 53.5 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily Ank_4 PF13637.6 EEA25824.1 - 2.5e-09 37.5 0.0 7.6e-06 26.4 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA25824.1 - 5.3e-09 36.5 0.0 3.5e-06 27.5 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA25824.1 - 0.00015 22.0 0.1 0.0067 16.7 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA25824.1 - 0.00031 20.9 0.0 0.49 11.1 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EEA25824.1 - 0.0028 18.0 0.0 0.24 11.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat adh_short_C2 PF13561.6 EEA25825.1 - 4.6e-53 180.2 0.1 2.7e-52 177.6 0.1 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA25825.1 - 9.7e-40 136.1 1.4 3.3e-39 134.4 1.4 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA25825.1 - 5.3e-08 33.0 0.2 1e-07 32.1 0.2 1.4 1 1 0 1 1 1 1 KR domain MR_MLE_C PF13378.6 EEA25826.1 - 8.1e-42 143.3 0.0 1.1e-41 142.8 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EEA25826.1 - 4.7e-09 36.5 0.0 7.8e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Fungal_trans PF04082.18 EEA25827.1 - 9.3e-23 80.6 0.0 1.5e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25827.1 - 1.2e-06 28.5 12.1 2.2e-06 27.7 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 EEA25827.1 - 0.0065 16.5 2.5 0.018 15.1 2.5 1.8 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 EEA25828.1 - 2.4e-70 236.9 0.0 3.5e-70 236.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25828.1 - 8.3e-52 176.0 0.0 1.3e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA25828.1 - 0.00015 20.7 0.9 0.00025 20.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EEA25828.1 - 0.022 14.1 0.0 0.29 10.4 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Thioredoxin_7 PF13899.6 EEA25829.1 - 1.7e-16 60.2 0.0 3.6e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EEA25829.1 - 2.1e-15 56.2 0.6 4.2e-15 55.3 0.6 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EEA25829.1 - 2.2e-08 34.1 0.0 7e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 UBX domain TAP_C PF03943.13 EEA25829.1 - 0.05 13.3 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 TAP C-terminal domain AAA PF00004.29 EEA25830.1 - 4.2e-12 46.6 0.0 1.2e-11 45.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA25830.1 - 2.4e-10 40.8 0.0 5.9e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA25830.1 - 2.4e-10 41.1 0.6 2.7e-09 37.6 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain Cdc6_C PF09079.11 EEA25830.1 - 8.8e-08 32.0 0.4 1.3e-06 28.3 0.1 3.0 2 2 0 2 2 2 1 CDC6, C terminal winged helix domain AAA_19 PF13245.6 EEA25830.1 - 0.0001 22.7 0.0 0.00027 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EEA25830.1 - 0.00038 19.9 0.0 0.00079 18.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_lid_10 PF17872.1 EEA25830.1 - 0.00046 20.3 0.0 0.00096 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA lid domain NACHT PF05729.12 EEA25830.1 - 0.0018 18.2 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_11 PF13086.6 EEA25830.1 - 0.0066 16.3 0.2 0.039 13.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EEA25830.1 - 0.013 15.1 0.0 0.041 13.4 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EEA25830.1 - 0.013 15.9 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.15 EEA25830.1 - 0.014 15.4 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RuvB_N PF05496.12 EEA25830.1 - 0.042 13.6 0.0 0.31 10.8 0.0 2.1 1 1 1 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain T2SSE PF00437.20 EEA25830.1 - 0.043 12.9 0.0 0.087 11.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 EEA25830.1 - 0.083 13.1 0.0 0.92 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 EEA25830.1 - 0.11 11.7 0.0 0.27 10.4 0.0 1.6 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 EEA25830.1 - 0.11 12.6 0.0 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA25830.1 - 0.12 12.9 0.0 0.31 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA25830.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 NTPase DUF815 PF05673.13 EEA25830.1 - 0.15 11.2 0.0 0.37 9.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Amidohydro_2 PF04909.14 EEA25831.1 - 2.9e-15 56.8 0.3 1.7e-14 54.3 0.3 2.1 1 1 0 1 1 1 1 Amidohydrolase ADH_N PF08240.12 EEA25832.1 - 4.9e-25 87.5 0.1 8.2e-25 86.8 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA25832.1 - 6.5e-23 81.1 0.6 9.4e-23 80.6 0.6 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EEA25832.1 - 0.0021 17.9 0.0 0.0042 17.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EEA25832.1 - 0.0071 17.4 0.0 0.013 16.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EEA25832.1 - 0.067 12.5 0.8 0.099 11.9 0.8 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RecC_C PF17946.1 EEA25833.1 - 0.057 13.2 1.0 0.45 10.3 0.0 2.5 2 1 0 2 2 2 0 RecC C-terminal domain zf-H2C2_2 PF13465.6 EEA25835.1 - 1.9e-11 43.9 19.5 7.1e-06 26.2 1.4 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EEA25835.1 - 4.1e-09 36.4 25.0 0.0047 17.3 8.1 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EEA25835.1 - 1.3e-06 28.2 18.8 0.0021 18.0 0.1 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EEA25835.1 - 4.6e-06 27.0 21.3 0.044 14.6 6.5 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-Di19 PF05605.12 EEA25835.1 - 0.0073 16.6 6.2 0.016 15.5 6.2 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 EEA25835.1 - 0.05 13.4 0.5 0.11 12.3 0.5 1.5 1 0 0 1 1 1 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.10 EEA25835.1 - 0.16 12.1 7.0 0.14 12.2 1.4 2.6 1 1 2 3 3 3 0 Zinc ribbon domain DUF3268 PF11672.8 EEA25835.1 - 0.17 12.2 2.0 0.17 12.2 0.7 1.6 1 1 0 1 1 1 0 zinc-finger-containing domain zf-C2H2_jaz PF12171.8 EEA25835.1 - 0.2 12.0 8.7 2 8.8 2.4 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DZR PF12773.7 EEA25835.1 - 0.22 11.6 6.5 1.7 8.7 5.8 2.2 1 1 1 2 2 2 0 Double zinc ribbon zf-CHCC PF10276.9 EEA25835.1 - 0.38 10.8 5.9 0.88 9.7 0.3 3.0 3 0 0 3 3 3 0 Zinc-finger domain zf-C2HC_2 PF13913.6 EEA25835.1 - 0.58 10.1 5.5 0.31 11.0 0.5 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_9 PF16293.5 EEA25835.1 - 0.78 9.6 3.2 1.9 8.4 0.3 2.6 1 1 2 3 3 3 0 C2H2 type zinc-finger (1 copy) HNH_5 PF14279.6 EEA25835.1 - 1.1 9.2 3.7 5.4 7.0 1.9 2.8 2 1 0 2 2 2 0 HNH endonuclease zinc_ribbon_15 PF17032.5 EEA25835.1 - 2.2 9.1 4.5 13 6.7 4.2 2.0 1 1 1 2 2 2 0 zinc-ribbon family GAGA PF09237.11 EEA25835.1 - 3 7.7 6.3 11 5.9 1.0 2.6 1 1 1 2 2 2 0 GAGA factor Rpr2 PF04032.16 EEA25835.1 - 5.9 7.2 7.4 33 4.9 3.6 2.7 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2_3rep PF18868.1 EEA25835.1 - 9.9 6.9 9.5 11 6.8 2.7 3.4 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats DUF3074 PF11274.8 EEA25836.1 - 2.8e-46 157.8 0.2 3.8e-46 157.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) PA28_alpha PF02251.18 EEA25836.1 - 0.071 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit Stk19 PF10494.9 EEA25837.1 - 1.1e-88 297.1 0.0 1.3e-88 296.9 0.0 1.1 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Glyco_transf_20 PF00982.21 EEA25838.1 - 1.2e-162 542.0 0.0 1.7e-162 541.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EEA25838.1 - 2.8e-40 137.9 0.0 4.7e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 EEA25838.1 - 0.087 12.5 0.3 0.15 11.7 0.3 1.3 1 0 0 1 1 1 0 Starch synthase catalytic domain 4HBT_3 PF13622.6 EEA25839.1 - 1.8e-47 162.7 0.6 2.1e-47 162.5 0.6 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EEA25839.1 - 0.00021 21.6 0.0 0.39 11.1 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily 4HBT PF03061.22 EEA25840.1 - 7.6e-08 32.6 0.0 1.1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Sporozoite_P67 PF05642.11 EEA25841.1 - 0.39 8.8 7.1 0.4 8.7 7.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4512 PF14975.6 EEA25841.1 - 4.1 8.2 8.0 22 5.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) FSA_C PF10479.9 EEA25841.1 - 5.2 5.1 12.5 6.1 4.8 12.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Herpes_capsid PF06112.11 EEA25841.1 - 9.3 6.3 14.1 16 5.5 14.1 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein eIF3m_C_helix PF18005.1 EEA25842.1 - 5.7e-10 38.7 3.0 1.2e-09 37.7 3.0 1.6 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix PCI PF01399.27 EEA25842.1 - 1.9e-09 38.0 0.0 8.6e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 PCI domain DNA_pol_phi PF04931.13 EEA25842.1 - 0.00016 20.0 0.2 0.00021 19.5 0.2 1.1 1 0 0 1 1 1 1 DNA polymerase phi K_channel_TID PF07941.11 EEA25842.1 - 0.037 14.5 5.1 0.11 13.0 5.1 1.8 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain ADK PF00406.22 EEA25843.1 - 2.7e-42 144.4 0.0 3.4e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EEA25843.1 - 1.6e-35 122.4 0.0 2.7e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA25843.1 - 1.7e-09 38.3 0.0 1e-08 35.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EEA25843.1 - 2.6e-06 27.2 0.0 0.0002 21.1 0.0 2.1 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 EEA25843.1 - 2.7e-06 27.6 0.0 7.2e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF202 PF02656.15 EEA25844.1 - 0.067 13.6 2.9 2.6 8.5 0.5 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF4271 PF14093.6 EEA25844.1 - 0.57 10.1 4.6 0.47 10.3 1.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4271) THEG4 PF15834.5 EEA25844.1 - 2.6 8.0 5.5 0.92 9.5 1.7 2.1 2 0 0 2 2 2 0 Testis highly expressed protein 4 Trep_Strep PF09605.10 EEA25844.1 - 6.4 6.7 9.0 0.12 12.3 1.5 1.8 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Cnd2 PF05786.14 EEA25845.1 - 0 1041.1 0.7 0 1040.9 0.7 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EEA25845.1 - 0.0044 17.2 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Na_Ca_ex PF01699.24 EEA25846.1 - 2e-48 164.2 42.3 6.2e-26 91.2 17.8 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Adeno_E3_14_5 PF04834.12 EEA25846.1 - 0.097 13.2 0.0 0.41 11.2 0.0 2.1 1 0 0 1 1 1 0 Early E3 14.5 kDa protein Phage_holin_2_4 PF16082.5 EEA25846.1 - 3.9 7.3 5.4 0.63 9.8 1.0 2.0 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like EF-hand_4 PF12763.7 EEA25847.1 - 2.1e-25 88.7 0.0 2.2e-13 50.1 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 EEA25847.1 - 2.4e-09 36.7 0.4 2.4e-09 36.7 0.4 2.0 2 0 0 2 2 2 1 WH2 motif DUF1720 PF08226.11 EEA25847.1 - 3.2e-09 37.1 56.9 2.2e-07 31.2 32.2 7.5 5 2 2 7 7 7 3 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 EEA25847.1 - 8.7e-05 21.8 0.0 0.0021 17.5 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EEA25847.1 - 0.0034 17.2 0.0 0.0079 16.0 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 EEA25847.1 - 0.013 15.9 0.0 0.013 15.9 0.0 3.3 4 0 0 4 4 4 0 EF-hand domain pair EF-hand_6 PF13405.6 EEA25847.1 - 0.043 13.8 0.0 1.2 9.3 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain RNA_pol_L_2 PF13656.6 EEA25848.1 - 1.4e-25 88.9 0.0 1.8e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EEA25848.1 - 2.3e-09 36.5 0.0 3.2e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SUIM_assoc PF16619.5 EEA25849.1 - 0.0016 18.5 2.0 0.0016 18.5 2.0 4.0 4 1 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 MRC1 PF09444.10 EEA25849.1 - 0.15 12.6 10.3 2.1 8.8 5.2 2.7 2 0 0 2 2 2 0 MRC1-like domain LRR_6 PF13516.6 EEA25850.1 - 4.9e-06 26.2 8.5 0.08 13.0 0.0 5.9 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.7 EEA25850.1 - 3.9e-05 23.9 9.3 0.03 14.8 2.7 5.6 4 3 3 7 7 7 2 Leucine Rich repeats (2 copies) FYVE PF01363.21 EEA25850.1 - 0.051 13.7 0.4 0.19 11.9 0.4 2.0 1 1 0 1 1 1 0 FYVE zinc finger DUF4604 PF15377.6 EEA25850.1 - 0.16 12.4 14.2 0.24 11.8 14.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Use1 PF09753.9 EEA25850.1 - 0.2 11.3 7.5 0.41 10.3 7.5 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 LRR_1 PF00560.33 EEA25850.1 - 0.64 10.8 8.1 13 6.8 0.0 5.1 3 2 0 3 3 3 0 Leucine Rich Repeat Pex19 PF04614.12 EEA25850.1 - 0.64 9.8 7.9 1.9 8.2 6.1 2.2 2 0 0 2 2 2 0 Pex19 protein family SNF2_N PF00176.23 EEA25851.1 - 4.9e-50 170.2 1.7 1e-48 165.8 0.5 2.9 2 1 1 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA25851.1 - 2.4e-17 63.3 0.0 3.4e-16 59.6 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EEA25851.1 - 5.2e-06 26.2 8.1 5.2e-06 26.2 8.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EEA25851.1 - 0.00018 21.6 0.0 0.00067 19.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EEA25851.1 - 0.00047 19.1 0.1 0.0012 17.8 0.0 1.6 2 0 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 zf-RING_UBOX PF13445.6 EEA25851.1 - 0.0017 18.3 5.6 0.0017 18.3 5.6 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EEA25851.1 - 0.012 15.9 9.9 0.012 15.9 9.9 2.6 2 0 0 2 2 2 0 Ring finger domain ERCC3_RAD25_C PF16203.5 EEA25851.1 - 0.029 13.6 0.0 0.054 12.7 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Zn_Tnp_IS91 PF14319.6 EEA25851.1 - 7.5 6.7 15.1 0.34 11.0 2.7 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain C2 PF00168.30 EEA25852.1 - 3.7e-13 49.6 0.0 6.9e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain ArfGap PF01412.18 EEA25853.1 - 1.5e-34 118.6 0.1 6.9e-34 116.4 0.1 2.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EEA25853.1 - 6.4e-23 81.7 14.7 1.1e-22 80.9 14.7 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EEA25853.1 - 1.3e-11 44.9 1.9 1.6e-11 44.7 0.2 2.1 2 0 0 2 2 2 1 PH domain V_ATPase_I PF01496.19 EEA25853.1 - 0.49 8.3 4.5 0.1 10.5 0.5 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family YTH PF04146.15 EEA25854.1 - 1.2e-61 207.4 0.0 2.9e-61 206.2 0.0 1.7 1 0 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 EEA25854.1 - 2.9e-07 30.2 0.0 6e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cwf_Cwc_15 PF04889.12 EEA25854.1 - 0.22 11.2 14.0 0.42 10.3 14.0 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 EEA25854.1 - 0.26 9.4 10.0 0.35 9.0 10.0 1.1 1 0 0 1 1 1 0 Nop14-like family PI3_PI4_kinase PF00454.27 EEA25856.1 - 6e-36 124.5 0.0 3.1e-33 115.6 0.0 3.1 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EEA25856.1 - 1.7e-24 86.3 0.2 3.6e-24 85.2 0.2 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EEA25856.1 - 0.014 14.7 0.0 0.036 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Pkinase PF00069.25 EEA25857.1 - 2.1e-78 263.3 0.0 2.8e-78 262.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25857.1 - 3.8e-39 134.5 0.0 5.4e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EEA25857.1 - 3.5e-17 62.5 0.1 7.3e-17 61.5 0.1 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EEA25857.1 - 3.2e-12 46.4 0.0 9.4e-09 35.0 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EEA25857.1 - 4.6e-07 29.0 0.0 4.6e-07 29.0 0.0 2.3 2 1 1 3 3 3 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 EEA25857.1 - 2e-06 28.0 0.0 5.8e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain APH PF01636.23 EEA25857.1 - 0.00039 20.4 0.2 0.0011 18.9 0.2 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EEA25857.1 - 0.0012 18.6 0.1 0.39 10.3 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EEA25857.1 - 0.0031 16.9 0.1 0.0058 16.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2961 PF11175.8 EEA25857.1 - 0.15 11.6 0.0 0.35 10.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2961) p450 PF00067.22 EEA25858.1 - 2.2e-73 247.6 0.0 2.8e-73 247.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ABC2_membrane_5 PF13346.6 EEA25858.1 - 0.046 13.3 1.3 0.084 12.4 1.3 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein IGR PF09597.10 EEA25859.1 - 1.7e-24 85.7 0.5 2.9e-24 84.9 0.5 1.4 1 0 0 1 1 1 1 IGR protein motif SAM_1 PF00536.30 EEA25859.1 - 0.16 12.5 0.0 0.29 11.6 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pkinase PF00069.25 EEA25860.1 - 2.5e-63 213.9 0.0 3e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25860.1 - 1.8e-33 115.9 0.0 2.4e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA25860.1 - 0.0059 16.0 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EEA25860.1 - 0.16 11.9 0.2 0.43 10.4 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family PgdA_N PF18627.1 EEA25860.1 - 0.17 11.5 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Peptidoglycan GlcNAc deacetylase N-terminal domain Kinesin PF00225.23 EEA25861.1 - 2.7e-97 325.7 0.9 4.8e-97 324.9 0.0 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EEA25861.1 - 2.8e-23 82.5 0.0 8.7e-23 80.9 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding PKcGMP_CC PF16808.5 EEA25861.1 - 0.26 11.2 6.2 0.15 11.9 0.5 3.1 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Acyl-CoA_dh_2 PF08028.11 EEA25862.1 - 0.014 15.7 0.0 0.031 14.6 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain NodZ PF05830.11 EEA25862.1 - 0.15 10.9 0.0 1.8 7.3 0.0 2.1 2 0 0 2 2 2 0 Nodulation protein Z (NodZ) DAGAT PF03982.13 EEA25863.1 - 1.4e-95 319.6 0.0 1.8e-95 319.3 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Rer1 PF03248.13 EEA25863.1 - 0.0052 16.5 0.5 0.011 15.4 0.2 1.6 2 0 0 2 2 2 1 Rer1 family G-patch PF01585.23 EEA25864.1 - 2.2e-05 24.2 0.1 0.00025 20.9 0.1 2.5 1 1 0 1 1 1 1 G-patch domain SRP-alpha_N PF04086.13 EEA25864.1 - 0.41 10.5 37.8 0.64 9.9 37.8 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TFIIF_alpha PF05793.12 EEA25864.1 - 4.2 5.9 48.2 5.9 5.4 47.3 1.7 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Syja_N PF02383.18 EEA25865.1 - 9.8e-72 242.0 0.0 1.4e-71 241.5 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EEA25865.1 - 1.2e-08 34.8 0.1 2.3e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ntox23 PF15528.6 EEA25865.1 - 0.12 12.5 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial toxin 23 DUF305 PF03713.13 EEA25866.1 - 0.076 13.1 0.5 0.12 12.5 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF305) DUF1359 PF07097.11 EEA25866.1 - 0.088 13.1 1.3 0.18 12.1 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1359) DDE_1 PF03184.19 EEA25867.1 - 1e-31 109.9 0.0 2.1e-31 108.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 EEA25868.1 - 3.2e-31 108.3 0.0 6.9e-31 107.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA25868.1 - 3.7e-07 30.1 0.2 8.5e-07 28.9 0.2 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA25868.1 - 4.2e-05 23.2 0.1 0.00012 21.7 0.1 1.8 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EEA25868.1 - 0.00018 21.3 0.0 0.0049 16.6 0.0 2.9 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_28 PF13518.6 EEA25868.1 - 0.004 17.3 0.2 0.016 15.4 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain zf-CCHC_4 PF14392.6 EEA25868.1 - 0.021 14.6 0.4 0.043 13.6 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF2089 PF09862.9 EEA25868.1 - 0.32 11.1 3.1 0.23 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) Histone_HNS PF00816.21 EEA25868.1 - 7.2 7.5 11.8 87 4.0 0.0 3.8 3 1 0 3 3 3 0 H-NS histone family HTH_Tnp_Tc5 PF03221.16 EEA25869.1 - 5.2e-15 55.2 1.9 3.4e-14 52.6 0.0 3.0 3 1 0 3 3 3 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 EEA25869.1 - 2.2e-11 43.8 0.1 5.4e-11 42.5 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_24 PF13412.6 EEA25869.1 - 0.043 13.4 0.0 0.1 12.2 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 EEA25869.1 - 0.065 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain HTH_AsnC-type PF13404.6 EEA25869.1 - 0.095 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain DDE_1 PF03184.19 EEA25870.1 - 1.8e-31 109.1 0.0 3.6e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA25870.1 - 7.7e-11 41.9 0.6 2.6e-10 40.2 0.0 2.2 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain zf-CCHC_2 PF13696.6 EEA25870.1 - 0.097 12.5 2.0 0.17 11.7 2.0 1.4 1 0 0 1 1 1 0 Zinc knuckle Glyco_transf_15 PF01793.16 EEA25870.1 - 0.16 11.2 0.2 0.64 9.2 0.0 1.9 2 0 0 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase zf-CCHC PF00098.23 EEA25870.1 - 0.41 10.8 2.5 0.79 9.9 2.5 1.5 1 0 0 1 1 1 0 Zinc knuckle NACHT PF05729.12 EEA25871.1 - 0.069 13.1 0.0 0.078 12.9 0.0 1.2 1 0 0 1 1 1 0 NACHT domain Glyco_hydro_72 PF03198.14 EEA25872.1 - 1.3e-35 123.2 0.7 5.8e-34 117.8 0.7 2.0 1 1 0 1 1 1 1 Glucanosyltransferase Adaptin_N PF01602.20 EEA25873.1 - 8.2e-80 268.8 0.2 1.6e-79 267.9 0.2 1.5 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EEA25873.1 - 0.00031 20.8 0.3 0.034 14.2 0.0 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA25873.1 - 0.0027 18.0 1.7 1.3 9.4 0.0 3.2 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 EEA25873.1 - 0.0055 16.9 0.5 42 4.8 0.0 4.6 4 0 0 4 4 4 0 HEAT repeat AbiEi_3 PF11459.8 EEA25873.1 - 0.13 11.9 0.0 0.42 10.3 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system TPR_14 PF13428.6 EEA25874.1 - 7.9e-10 38.7 0.6 0.00091 19.9 0.1 4.8 3 2 2 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA25874.1 - 6.6e-08 32.4 1.0 0.0021 18.3 0.1 4.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA25874.1 - 5.9e-06 25.9 0.9 0.14 11.9 0.0 3.6 3 0 0 3 3 3 2 TPR repeat TPR_8 PF13181.6 EEA25874.1 - 7.2e-06 25.8 0.1 0.0007 19.6 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA25874.1 - 1.7e-05 24.6 0.6 0.0096 16.0 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA25874.1 - 6e-05 22.7 0.0 0.013 15.3 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA25874.1 - 0.00018 22.0 1.0 0.019 15.4 0.2 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA25874.1 - 0.012 16.2 0.3 0.1 13.2 0.1 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat MCD_N PF17408.2 EEA25874.1 - 0.025 14.7 0.1 4.3 7.5 0.0 3.5 3 1 0 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain TPR_9 PF13371.6 EEA25874.1 - 0.074 13.2 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat SUKH-4 PF14435.6 EEA25874.1 - 0.095 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 SUKH-4 immunity protein CENP-Q PF13094.6 EEA25876.1 - 0.083 13.1 5.8 0.17 12.1 3.6 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Aldedh PF00171.22 EEA25877.1 - 7.6e-13 47.8 10.7 1.9e-11 43.2 6.6 2.9 2 1 0 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA25877.1 - 0.0095 15.4 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Ribosomal_L18 PF17135.4 EEA25878.1 - 2.2e-96 320.7 4.5 2.4e-96 320.5 4.5 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EEA25878.1 - 0.0001 23.0 0.2 0.0001 23.0 0.2 2.2 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Mito_carr PF00153.27 EEA25879.1 - 2.7e-72 238.8 1.8 9.7e-24 83.1 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA25879.1 - 7.2e-05 22.1 0.6 0.025 13.7 0.0 2.9 3 1 1 4 4 4 2 Gammaproteobacterial serine protease Mito_carr PF00153.27 EEA25880.1 - 1.2e-72 239.9 1.8 7.4e-24 83.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA25880.1 - 3.9e-05 23.0 0.4 0.021 14.0 0.0 3.0 3 1 1 4 4 4 2 Gammaproteobacterial serine protease Mito_carr PF00153.27 EEA25881.1 - 5.2e-52 173.7 1.6 2.3e-22 78.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA25881.1 - 0.00049 19.3 0.7 0.24 10.5 0.1 3.0 3 1 1 4 4 4 2 Gammaproteobacterial serine protease RRM_1 PF00076.22 EEA25882.1 - 2.1e-12 46.7 0.0 2.8e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA25882.1 - 0.00055 19.9 0.0 0.00077 19.4 0.0 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif CH PF00307.31 EEA25883.1 - 4.4e-75 248.9 0.0 1.4e-20 73.5 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EEA25883.1 - 3.2e-06 27.5 2.1 3.8e-05 24.1 0.4 3.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EEA25883.1 - 0.00039 19.8 2.6 1.1 8.9 0.2 3.7 3 0 0 3 3 3 2 EF hand CAMSAP_CH PF11971.8 EEA25883.1 - 0.0014 18.5 0.0 0.97 9.3 0.0 3.5 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_6 PF13405.6 EEA25883.1 - 0.017 15.0 3.9 0.4 10.7 0.1 3.3 3 0 0 3 3 3 0 EF-hand domain DDHD PF02862.17 EEA25884.1 - 9e-49 166.6 0.0 9e-49 166.6 0.0 4.2 4 0 0 4 4 4 1 DDHD domain PXA PF02194.15 EEA25884.1 - 1.1e-32 113.5 0.1 3.2e-32 112.0 0.1 1.9 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 EEA25884.1 - 3.2e-19 69.5 0.7 1.2e-18 67.7 0.0 2.5 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 EEA25884.1 - 3.1e-07 30.4 0.2 1.2e-06 28.5 0.2 2.0 1 0 0 1 1 1 1 PX domain PC4 PF02229.16 EEA25885.1 - 1.2e-25 88.9 0.0 1.3e-24 85.5 0.0 2.3 2 1 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) Hydantoinase_B PF02538.14 EEA25886.1 - 7.5e-223 740.6 0.0 9.8e-223 740.2 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EEA25886.1 - 1.9e-102 342.5 0.2 4.1e-102 341.3 0.2 1.6 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EEA25886.1 - 1.3e-62 210.7 0.6 8.3e-61 204.8 0.0 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Creatininase PF02633.14 EEA25886.1 - 0.013 14.9 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 Creatinine amidohydrolase ZYG-11_interact PF05884.12 EEA25886.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 MIT PF04212.18 EEA25887.1 - 1e-13 51.1 1.7 2.2e-13 50.1 1.7 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain ELH PF02323.15 EEA25887.1 - 0.0064 15.9 4.5 0.0064 15.9 4.5 2.5 2 0 0 2 2 2 1 Egg-laying hormone precursor MukE PF04288.13 EEA25887.1 - 0.012 14.5 0.1 0.028 13.4 0.1 1.5 1 0 0 1 1 1 0 MukE-like family Utp14 PF04615.13 EEA25887.1 - 9.4 4.7 12.1 0.49 8.9 6.0 1.9 1 1 1 2 2 2 0 Utp14 protein PBP1_TM PF14812.6 EEA25888.1 - 6.5 7.2 27.1 0.042 14.2 8.2 4.6 5 0 0 5 5 5 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_M24 PF00557.24 EEA25889.1 - 1.2e-55 188.5 0.1 1.7e-55 188.0 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EEA25889.1 - 7.8e-26 90.2 0.0 2.4e-25 88.6 0.0 1.8 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain Peptidase_M1 PF01433.20 EEA25890.1 - 1.6e-45 155.4 0.8 2.3e-45 154.8 0.8 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EEA25890.1 - 8.9e-35 119.2 0.0 2.3e-34 117.9 0.0 1.8 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EEA25890.1 - 4.7e-30 105.2 0.1 7.2e-30 104.6 0.1 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain COX5A PF02284.16 EEA25890.1 - 0.0035 17.3 0.3 0.0081 16.2 0.3 1.6 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Peptidase_MA_2 PF13485.6 EEA25890.1 - 0.068 12.8 0.1 1.3 8.6 0.1 2.2 2 0 0 2 2 2 0 Peptidase MA superfamily TbpB_B_D PF01298.18 EEA25890.1 - 0.13 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 C-lobe and N-lobe beta barrels of Tf-binding protein B Peptidase_M61 PF05299.12 EEA25890.1 - 0.3 11.5 2.9 5.5 7.4 2.9 2.6 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Ubiq_cyt_C_chap PF03981.12 EEA25891.1 - 4.1e-37 127.4 0.1 7.4e-37 126.6 0.1 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone TIP41 PF04176.13 EEA25892.1 - 1.5e-70 236.2 0.0 1.8e-70 235.9 0.0 1.1 1 0 0 1 1 1 1 TIP41-like family DUF4279 PF14106.6 EEA25892.1 - 0.069 13.4 0.1 0.77 10.0 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4279) Pkinase PF00069.25 EEA25893.1 - 2e-72 243.7 0.0 2.6e-72 243.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25893.1 - 1.3e-43 149.1 0.0 1.8e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA25893.1 - 2.8e-07 30.2 0.0 1.5e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EEA25893.1 - 0.00026 20.4 0.2 0.00048 19.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EEA25893.1 - 0.0044 16.0 0.1 0.0069 15.4 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EEA25893.1 - 0.02 14.5 0.0 0.061 12.9 0.0 1.6 1 1 1 2 2 2 0 RIO1 family FTA2 PF13095.6 EEA25893.1 - 0.04 13.5 0.1 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EEA25893.1 - 0.041 13.4 0.1 0.1 12.1 0.0 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 EEA25893.1 - 0.07 13.0 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M76 PF09768.9 EEA25894.1 - 3.6e-73 244.9 2.7 4.3e-73 244.7 2.7 1.1 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M91 PF14891.6 EEA25894.1 - 0.015 15.6 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 Effector protein SprT-like PF10263.9 EEA25894.1 - 0.016 15.0 1.9 0.023 14.5 0.8 1.8 1 1 1 2 2 2 0 SprT-like family HNH_5 PF14279.6 EEA25894.1 - 0.045 13.6 2.2 0.19 11.6 0.3 2.5 2 0 0 2 2 2 0 HNH endonuclease Peptidase_M13 PF01431.21 EEA25894.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M13 AA_kinase PF00696.28 EEA25895.1 - 1.6e-41 142.5 0.6 2.2e-41 142.1 0.6 1.1 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EEA25895.1 - 1.1e-13 50.9 0.1 5e-13 48.8 0.0 2.1 2 0 0 2 2 2 1 PUA domain GPI-anchored PF10342.9 EEA25896.1 - 4.6e-15 56.2 0.0 1.2e-14 54.8 0.0 1.7 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family KRE9 PF05390.11 EEA25896.1 - 4.5e-14 53.0 3.4 4.5e-14 53.0 3.4 1.9 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 KRE9 PF05390.11 EEA25897.1 - 2.5e-14 53.8 3.4 2.5e-14 53.8 3.4 2.1 2 1 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 KRE9 PF05390.11 EEA25898.1 - 2.5e-14 53.8 3.4 2.5e-14 53.8 3.4 2.1 2 1 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 SRPRB PF09439.10 EEA25899.1 - 3.4e-25 88.5 1.1 4.2e-23 81.7 1.1 3.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EEA25899.1 - 0.00098 18.6 0.3 0.011 15.2 0.0 2.6 2 1 0 2 2 2 1 ADP-ribosylation factor family AAA_16 PF13191.6 EEA25899.1 - 0.0028 18.0 0.2 0.0076 16.6 0.1 1.8 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA25899.1 - 0.037 13.9 1.7 0.16 11.8 0.8 2.3 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EEA25899.1 - 0.056 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter RRM_Rrp7 PF17799.1 EEA25899.1 - 0.088 12.6 0.1 0.26 11.1 0.0 1.7 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain AAA_21 PF13304.6 EEA25899.1 - 0.089 12.6 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA25899.1 - 0.15 12.5 2.1 0.38 11.2 2.1 1.8 1 1 0 1 1 1 0 AAA domain B277 PF17623.2 EEA25899.1 - 2.3 7.3 7.5 1.1 8.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function PALP PF00291.25 EEA25900.1 - 9.8e-66 222.1 0.1 1.3e-65 221.8 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EEA25900.1 - 1.6e-11 44.4 0.0 8.2e-09 35.8 0.0 2.9 2 0 0 2 2 2 2 CBS domain DUF5496 PF17600.2 EEA25900.1 - 0.017 15.1 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5496) GHMP_kinases_C PF08544.13 EEA25900.1 - 0.075 13.4 0.1 8.6 6.8 0.0 2.6 2 0 0 2 2 2 0 GHMP kinases C terminal DUF2605 PF10792.9 EEA25901.1 - 1.9 8.4 6.2 2.9 7.9 1.4 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF2605) V_ATPase_I PF01496.19 EEA25901.1 - 4.4 5.1 21.7 0.28 9.0 7.2 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Type2_restr_D3 PF16902.5 EEA25901.1 - 8.1 6.5 8.2 0.68 9.9 0.1 3.4 5 0 0 5 5 5 0 Type-2 restriction enzyme D3 domain Cyclin PF08613.11 EEA25903.1 - 6.4e-40 137.2 0.0 9.7e-40 136.6 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EEA25903.1 - 0.021 14.6 0.1 0.036 13.8 0.1 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Cyclin PF08613.11 EEA25904.1 - 6.4e-40 137.2 0.0 9.7e-40 136.6 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EEA25904.1 - 0.021 14.6 0.1 0.036 13.8 0.1 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain DHHC PF01529.20 EEA25905.1 - 3.7e-34 117.7 14.3 3.7e-34 117.7 14.3 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EEA25905.1 - 4.4e-27 94.5 0.0 2.3e-12 47.3 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA25905.1 - 1.9e-24 85.4 0.9 3.5e-07 30.4 0.0 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA25905.1 - 6.5e-23 78.3 2.6 6.3e-07 29.2 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EEA25905.1 - 5.6e-21 74.0 0.6 4.6e-06 26.8 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EEA25905.1 - 8e-17 61.4 1.5 0.00014 22.3 0.0 4.6 1 1 4 5 5 5 4 Ankyrin repeats (many copies) K_oxygenase PF13434.6 EEA25906.1 - 7.6e-109 364.0 0.0 9e-109 363.7 0.0 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EEA25906.1 - 5e-07 29.2 0.0 6.6e-05 22.3 0.0 2.6 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA25906.1 - 6.9e-07 29.4 0.0 1.6e-05 24.9 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding DUF3990 PF13151.6 EEA25906.1 - 0.085 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) AMP-binding PF00501.28 EEA25907.1 - 3e-227 754.2 0.0 3.2e-80 269.8 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EEA25907.1 - 3.8e-203 675.3 0.7 4.4e-40 137.7 0.2 7.6 6 1 0 6 6 6 6 Condensation domain PP-binding PF00550.25 EEA25907.1 - 1.6e-54 182.1 14.4 2.8e-12 46.8 0.3 7.1 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA25907.1 - 2.3e-15 57.3 0.0 0.00095 20.1 0.0 3.8 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EEA25907.1 - 0.0039 15.9 1.4 11 4.6 0.0 5.1 7 0 0 7 7 7 1 Transferase family Imm1 PF14430.6 EEA25907.1 - 0.096 13.3 0.2 14 6.4 0.0 3.6 3 0 0 3 3 3 0 Immunity protein Imm1 Pkinase PF00069.25 EEA25908.1 - 4.6e-44 150.8 0.0 7.5e-42 143.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA25908.1 - 1.1e-24 87.1 0.0 2.6e-24 85.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase OB_NTP_bind PF07717.16 EEA25909.1 - 1.2e-22 80.0 0.0 2.5e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EEA25909.1 - 1.2e-19 70.6 0.0 1.2e-19 70.6 0.0 4.4 4 1 0 4 4 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EEA25909.1 - 9.7e-13 48.4 0.0 2.1e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA25909.1 - 1.5e-07 31.4 0.1 3.3e-07 30.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA25909.1 - 1.8e-05 25.0 0.3 0.00013 22.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EEA25909.1 - 0.00026 20.8 0.1 0.00026 20.8 0.1 1.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EEA25909.1 - 0.00076 18.6 0.0 0.0018 17.4 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EEA25909.1 - 0.00078 19.8 0.2 0.0017 18.7 0.2 1.6 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EEA25909.1 - 0.0065 16.1 0.3 0.019 14.6 0.3 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ATPase PF06745.13 EEA25909.1 - 0.032 13.6 0.0 0.068 12.5 0.0 1.5 1 0 0 1 1 1 0 KaiC FtsK_SpoIIIE PF01580.18 EEA25909.1 - 0.081 12.3 0.0 0.25 10.6 0.0 1.8 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EEA25909.1 - 0.1 13.1 0.6 0.57 10.7 0.1 2.4 1 1 1 2 2 2 0 ABC transporter AAA_23 PF13476.6 EEA25909.1 - 0.12 12.9 0.0 0.12 12.9 0.0 3.6 2 1 0 2 2 1 0 AAA domain ResIII PF04851.15 EEA25909.1 - 0.36 10.8 1.9 2.9 7.8 0.1 2.9 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit Cyt-b5 PF00173.28 EEA25910.1 - 3.9e-22 78.2 0.1 4.4e-22 78.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain V-ATPase_H_C PF11698.8 EEA25910.1 - 0.11 12.7 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 V-ATPase subunit H Cyt-b5 PF00173.28 EEA25911.1 - 1.4e-18 66.8 0.0 1.5e-18 66.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cyt-b5 PF00173.28 EEA25912.1 - 3.9e-22 78.2 0.1 4.4e-22 78.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain V-ATPase_H_C PF11698.8 EEA25912.1 - 0.11 12.7 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 V-ATPase subunit H Zip PF02535.22 EEA25913.1 - 1.3e-61 208.7 0.0 1.5e-61 208.5 0.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Acetyltransf_1 PF00583.25 EEA25914.1 - 3.5e-10 40.1 0.0 6.2e-10 39.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA25914.1 - 4.6e-06 26.6 0.0 1.1e-05 25.3 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA25914.1 - 2.2e-05 24.8 0.0 4.1e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA25914.1 - 0.011 15.7 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA25914.1 - 0.076 13.2 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Mcp5_PH PF12814.7 EEA25915.1 - 1.5e-46 157.5 0.1 3.2e-46 156.4 0.1 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Fez1 PF06818.15 EEA25915.1 - 5.1e-07 30.3 13.6 5.1e-07 30.3 13.6 1.8 2 0 0 2 2 2 1 Fez1 TPR_MLP1_2 PF07926.12 EEA25915.1 - 4.9e-05 23.4 17.4 0.015 15.3 8.1 2.5 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein DUF4482 PF14818.6 EEA25915.1 - 0.00079 20.3 0.2 0.00079 20.3 0.2 3.7 2 1 1 3 3 3 1 Domain of unknown function (DUF4482) DUF724 PF05266.14 EEA25915.1 - 0.0093 15.8 6.3 0.019 14.8 6.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Cnn_1N PF07989.11 EEA25915.1 - 0.016 15.4 11.2 0.052 13.7 6.1 2.6 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 MSL1_dimer PF16801.5 EEA25915.1 - 0.37 10.6 4.2 2.6 7.9 0.7 2.4 2 0 0 2 2 2 0 Dimerisation domain of Male-specific-Lethal 1 TACC_C PF05010.14 EEA25915.1 - 0.38 10.5 16.7 1.2 8.9 16.4 1.8 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal HIP1_clath_bdg PF16515.5 EEA25915.1 - 0.66 10.6 11.8 0.1 13.2 3.9 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Golgin_A5 PF09787.9 EEA25915.1 - 0.91 8.9 15.5 1.6 8.1 15.5 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DivIC PF04977.15 EEA25915.1 - 0.99 9.2 10.4 0.36 10.6 0.5 3.9 2 1 2 4 4 4 0 Septum formation initiator FliJ PF02050.16 EEA25915.1 - 1.1 9.5 12.1 1.6 8.9 10.9 2.0 2 0 0 2 2 2 0 Flagellar FliJ protein GAS PF13851.6 EEA25915.1 - 2 7.7 20.9 4.4 6.6 20.9 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 EEA25915.1 - 2.8 8.0 18.6 0.025 14.7 5.7 2.5 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EEA25915.1 - 6.8 6.7 19.3 11 6.1 18.8 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Abhydrolase_1 PF00561.20 EEA25917.1 - 1.1e-26 94.0 0.1 4.8e-26 91.9 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA25917.1 - 5.4e-11 42.2 0.0 5.4e-10 38.9 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA25917.1 - 2.6e-09 38.0 1.3 6.1e-09 36.8 1.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EEA25917.1 - 0.0019 18.3 0.0 0.012 15.7 0.0 2.0 2 0 0 2 2 2 1 TAP-like protein Ndr PF03096.14 EEA25917.1 - 0.018 13.8 0.0 0.024 13.3 0.0 1.1 1 0 0 1 1 1 0 Ndr family Esterase PF00756.20 EEA25917.1 - 0.033 13.8 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Peptidase_S28 PF05577.12 EEA25917.1 - 0.19 10.5 0.0 0.28 9.9 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 AMP-binding PF00501.28 EEA25919.1 - 6.1e-61 206.3 0.0 1e-60 205.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA25919.1 - 1.4e-11 45.2 0.0 4.3e-11 43.6 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain BolA PF01722.18 EEA25920.1 - 5.5e-30 103.5 1.8 7.4e-30 103.1 1.8 1.2 1 0 0 1 1 1 1 BolA-like protein Cofilin_ADF PF00241.20 EEA25920.1 - 0.04 13.7 0.0 0.063 13.1 0.0 1.6 1 1 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein Syntaxin PF00804.25 EEA25921.1 - 5.2e-12 45.9 12.4 5.2e-12 45.9 12.4 1.6 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 EEA25921.1 - 9.4e-11 41.5 2.8 4.2e-10 39.5 2.8 2.2 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.9 EEA25921.1 - 0.0073 16.1 11.0 0.021 14.6 10.9 1.8 1 1 0 1 1 1 1 Membrane fusion protein Use1 ETRAMP PF09716.10 EEA25921.1 - 0.0083 16.2 0.1 0.014 15.4 0.1 1.8 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Syntaxin_2 PF14523.6 EEA25921.1 - 0.012 15.9 7.0 0.012 15.9 7.0 2.7 2 2 0 2 2 2 0 Syntaxin-like protein T7SS_ESX_EspC PF10824.8 EEA25921.1 - 0.047 14.2 7.6 0.56 10.7 0.7 3.7 1 1 3 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm VitD-bind_III PF09164.10 EEA25921.1 - 0.06 13.4 0.1 0.18 11.8 0.1 1.9 2 0 0 2 2 2 0 Vitamin D binding protein, domain III BAR_3 PF16746.5 EEA25921.1 - 0.062 13.0 6.9 0.051 13.3 1.2 2.7 2 1 1 3 3 3 0 BAR domain of APPL family ApoLp-III PF07464.11 EEA25921.1 - 0.097 12.8 10.5 1.7 8.7 1.3 2.5 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) HisKA_3 PF07730.13 EEA25921.1 - 0.35 11.4 0.0 0.35 11.4 0.0 3.8 3 1 1 4 4 4 0 Histidine kinase Prominin PF05478.11 EEA25921.1 - 0.54 8.1 9.2 0.46 8.4 6.9 1.7 1 1 0 1 1 1 0 Prominin Mod_r PF07200.13 EEA25921.1 - 0.71 10.0 13.1 1.2 9.3 3.9 2.7 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2207 PF09972.9 EEA25921.1 - 1.4 7.6 4.4 2.2 7.0 0.1 2.0 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Muted PF14942.6 EEA25921.1 - 2.3 8.6 11.4 12 6.3 4.8 2.5 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein NPV_P10 PF05531.12 EEA25921.1 - 2.4 8.7 8.6 1.1 9.8 0.3 3.1 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Syntaxin-6_N PF09177.11 EEA25921.1 - 3 8.5 11.1 0.69 10.5 0.5 3.1 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Fib_alpha PF08702.10 EEA25921.1 - 3.2 7.9 13.4 1.6 8.9 2.9 2.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF148 PF02520.17 EEA25921.1 - 3.6 7.7 15.0 0.37 10.9 2.5 2.8 2 1 1 3 3 3 0 Domain of unknown function DUF148 Fungal_trans PF04082.18 EEA25922.1 - 3.9e-24 85.1 1.1 6.6e-24 84.4 1.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAPRTase PF04095.16 EEA25923.1 - 1.8e-53 181.6 0.0 6.1e-28 98.1 0.2 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EEA25923.1 - 4.6e-36 123.9 0.1 8.8e-36 123.0 0.1 1.5 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain ING PF12998.7 EEA25924.1 - 1.4e-24 86.6 5.2 2.4e-24 85.8 5.2 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EEA25924.1 - 2.1e-05 24.3 9.3 3.9e-05 23.4 9.3 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EEA25924.1 - 0.045 14.0 0.1 0.12 12.6 0.1 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain CREPT PF16566.5 EEA25924.1 - 0.19 11.9 3.6 0.62 10.2 3.6 1.8 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour PHD_2 PF13831.6 EEA25924.1 - 0.58 9.8 3.8 1.2 8.8 3.8 1.5 1 0 0 1 1 1 0 PHD-finger DUF5435 PF17503.2 EEA25924.1 - 1.1 8.9 3.3 10 5.8 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5435) RNA_pol_Rpc34 PF05158.12 EEA25925.1 - 1.5e-98 330.3 0.0 1.7e-98 330.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit PadR PF03551.14 EEA25925.1 - 0.0039 17.1 0.5 0.11 12.4 0.0 2.6 2 0 0 2 2 2 1 Transcriptional regulator PadR-like family MarR PF01047.22 EEA25925.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 MarR family TPR_1 PF00515.28 EEA25926.1 - 1.1e-40 135.8 21.8 3.5e-05 23.4 0.0 8.9 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EEA25926.1 - 6.5e-34 113.3 25.3 0.00091 19.2 0.2 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat STI1 PF17830.1 EEA25926.1 - 1.2e-33 114.8 7.8 5.1e-18 64.7 0.1 2.7 2 0 0 2 2 2 2 STI1 domain TPR_8 PF13181.6 EEA25926.1 - 4.7e-16 57.6 25.9 3.9e-05 23.5 0.2 8.4 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 EEA25926.1 - 1.7e-15 56.4 23.0 8.7e-05 22.1 0.2 8.9 6 2 3 9 9 9 4 TPR repeat TPR_12 PF13424.6 EEA25926.1 - 5.8e-15 55.4 23.1 6.7e-07 29.5 0.3 6.6 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 EEA25926.1 - 4.2e-12 46.5 19.2 0.0008 20.0 0.0 6.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA25926.1 - 5.9e-11 42.7 21.0 0.037 14.5 0.2 7.3 3 3 2 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EEA25926.1 - 3.3e-09 36.1 12.5 0.0048 16.8 0.0 7.4 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA25926.1 - 1.6e-08 34.6 23.0 0.17 12.8 0.1 9.4 6 2 4 10 10 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 EEA25926.1 - 3.1e-08 33.6 14.3 0.017 15.2 0.3 6.1 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EEA25926.1 - 5e-07 29.6 8.6 0.23 11.9 0.1 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EEA25926.1 - 0.0096 15.8 17.0 0.72 9.8 0.0 6.4 6 1 1 7 7 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EEA25926.1 - 0.016 15.3 4.5 17 5.6 0.0 5.4 6 1 1 7 7 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EEA25926.1 - 0.016 15.8 21.9 1.5 9.6 0.0 7.7 8 0 0 8 8 6 0 Tetratricopeptide repeat Inhibitor_I9 PF05922.16 EEA25926.1 - 0.097 13.4 0.2 0.47 11.1 0.2 2.3 1 0 0 1 1 1 0 Peptidase inhibitor I9 ANAPC3 PF12895.7 EEA25926.1 - 0.1 12.9 13.4 1.5 9.1 0.7 4.5 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 GlnE PF03710.15 EEA25926.1 - 0.16 11.4 6.4 3.9 6.8 6.4 2.5 1 1 0 1 1 1 0 Glutamate-ammonia ligase adenylyltransferase MIT PF04212.18 EEA25926.1 - 2.1 8.5 26.3 10 6.3 0.2 6.4 6 1 0 6 6 5 0 MIT (microtubule interacting and transport) domain ProSAAS PF07259.12 EEA25926.1 - 2.3 8.1 10.4 0.055 13.4 3.3 2.0 2 0 0 2 2 2 0 ProSAAS precursor PspA_IM30 PF04012.12 EEA25926.1 - 2.4 7.7 26.4 0.18 11.4 0.9 3.3 3 1 0 4 4 4 0 PspA/IM30 family TPR_20 PF14561.6 EEA25926.1 - 2.4 8.5 25.6 0.22 11.9 0.3 5.5 4 3 2 6 6 6 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EEA25926.1 - 4.2 6.9 11.9 20 4.8 0.1 5.6 6 0 0 6 6 6 0 SHNi-TPR NARP1 PF12569.8 EEA25926.1 - 8.7 5.1 25.7 0.044 12.7 0.6 4.2 3 2 2 5 5 5 0 NMDA receptor-regulated protein 1 AMP-binding PF00501.28 EEA25927.1 - 9.7e-78 261.6 0.0 1.2e-77 261.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EEA25927.1 - 2.2e-16 59.5 1.3 4.9e-16 58.4 0.4 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EEA25927.1 - 1.2e-14 55.1 0.1 6.7e-14 52.6 0.0 2.4 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain AAA PF00004.29 EEA25928.1 - 1.4e-14 54.7 0.0 2.4e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA25928.1 - 0.00012 22.5 0.1 0.00036 21.0 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EEA25928.1 - 0.00067 19.7 0.0 0.0015 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA25928.1 - 0.00071 19.9 0.3 0.0052 17.1 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 EEA25928.1 - 0.04 14.3 0.6 0.092 13.1 0.6 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EEA25928.1 - 0.046 13.4 0.3 0.096 12.4 0.3 1.4 1 0 0 1 1 1 0 AAA domain FlxA PF14282.6 EEA25928.1 - 0.054 13.5 1.1 0.14 12.2 1.1 1.6 1 0 0 1 1 1 0 FlxA-like protein SPOR PF05036.13 EEA25928.1 - 0.076 13.4 0.1 27 5.2 0.0 2.9 2 0 0 2 2 2 0 Sporulation related domain Sigma54_activat PF00158.26 EEA25928.1 - 0.08 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Torsin PF06309.11 EEA25928.1 - 0.082 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Torsin Img2 PF05046.14 EEA25928.1 - 0.09 13.1 0.3 0.39 11.0 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) IstB_IS21 PF01695.17 EEA25928.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Zot PF05707.12 EEA25928.1 - 0.14 11.8 0.1 1.2 8.8 0.0 2.2 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) AAA_28 PF13521.6 EEA25928.1 - 0.18 12.0 0.7 0.85 9.8 0.3 2.2 1 1 1 2 2 2 0 AAA domain AAA_11 PF13086.6 EEA25928.1 - 0.29 10.9 0.7 0.65 9.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain Isochorismatase PF00857.20 EEA25929.1 - 1.7e-17 64.1 0.0 2.4e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family VioE PF18234.1 EEA25929.1 - 0.18 11.9 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Violacein biosynthetic enzyme VioE Zn_clus PF00172.18 EEA25930.1 - 5.4e-09 36.0 10.9 1.2e-08 35.0 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA25930.1 - 0.0054 15.8 0.1 0.01 14.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ras PF00071.22 EEA25931.1 - 1.8e-51 174.0 0.8 2.7e-50 170.2 0.8 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EEA25931.1 - 1.4e-18 67.3 0.1 2.1e-17 63.4 0.1 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA25931.1 - 0.00054 19.5 0.1 0.0033 16.9 0.1 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_25 PF13481.6 EEA25931.1 - 0.042 13.4 0.1 0.33 10.5 0.1 2.2 2 1 0 2 2 2 0 AAA domain SRPRB PF09439.10 EEA25931.1 - 0.044 13.2 0.0 0.7 9.3 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EEA25931.1 - 0.076 12.5 0.2 1.9 8.0 0.0 2.5 2 1 1 3 3 3 0 Ferrous iron transport protein B Septin PF00735.18 EEA25931.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 EEA25931.1 - 0.17 11.7 0.0 9.2 6.1 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase DDE_3 PF13358.6 EEA25932.1 - 4.5e-08 33.0 0.1 1.2e-07 31.6 0.1 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 EEA25932.1 - 5e-06 26.1 0.2 2e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 EEA25932.1 - 0.00033 21.2 0.1 0.00033 21.2 0.1 3.4 4 1 0 4 4 4 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EEA25932.1 - 0.012 15.3 0.1 0.025 14.2 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_28 PF13518.6 EEA25932.1 - 0.022 14.9 0.3 0.074 13.2 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 EEA25932.1 - 0.056 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB CinA PF02464.17 EEA25933.1 - 8.9e-37 126.0 0.2 9.9e-37 125.9 0.2 1.0 1 0 0 1 1 1 1 Competence-damaged protein Kinesin_assoc PF16183.5 EEA25933.1 - 0.015 15.4 0.0 0.021 15.0 0.0 1.1 1 0 0 1 1 1 0 Kinesin-associated SHMT PF00464.19 EEA25934.1 - 5.7e-198 657.4 0.0 6.8e-198 657.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase MOSC PF03473.17 EEA25935.1 - 3.8e-29 101.4 0.0 5.6e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EEA25935.1 - 6.3e-10 39.0 0.0 1.5e-09 37.7 0.0 1.9 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain Tyrosinase PF00264.20 EEA25936.1 - 9.2e-53 179.8 0.1 1.5e-52 179.1 0.0 1.4 2 0 0 2 2 2 1 Common central domain of tyrosinase AA_permease_2 PF13520.6 EEA25937.1 - 3.7e-51 174.3 52.7 4.4e-51 174.0 52.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA25937.1 - 1.7e-24 86.3 46.6 3.2e-24 85.4 46.7 1.3 1 1 0 1 1 1 1 Amino acid permease Patatin PF01734.22 EEA25938.1 - 2.7e-14 53.9 0.0 7.2e-14 52.4 0.0 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase DUF2931 PF11153.8 EEA25938.1 - 0.14 11.9 0.0 0.47 10.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2931) Mg_trans_NIPA PF05653.14 EEA25939.1 - 1.4e-90 303.4 28.4 1.8e-90 303.0 28.4 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EEA25939.1 - 0.00031 20.9 6.1 0.00031 20.9 6.1 3.3 3 0 0 3 3 3 1 EamA-like transporter family rve_3 PF13683.6 EEA25939.1 - 0.05 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain DUF5362 PF17319.2 EEA25939.1 - 0.099 12.5 3.3 0.12 12.3 0.0 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5362) BRCT_2 PF16589.5 EEA25940.1 - 5.7e-10 39.5 0.0 2.5e-09 37.4 0.0 2.1 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EEA25940.1 - 0.0015 18.4 0.3 0.0059 16.5 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 EEA25940.1 - 0.012 16.0 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EEA25940.1 - 0.09 13.1 0.0 0.38 11.1 0.0 2.0 1 1 0 1 1 1 0 DNA ligase 3 BRCT domain Trypan_PARP PF05887.11 EEA25940.1 - 3.6 7.6 9.6 0.51 10.3 4.7 2.0 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) KilA-N PF04383.13 EEA25941.1 - 0.00011 22.0 0.0 0.0037 17.1 0.0 2.5 1 1 0 1 1 1 1 KilA-N domain DUF4587 PF15248.6 EEA25941.1 - 0.51 11.2 4.9 0.34 11.8 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4587) HA2 PF04408.23 EEA25942.1 - 9.9e-16 58.0 0.0 3.4e-15 56.2 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EEA25942.1 - 3.7e-14 53.0 0.8 1.4e-13 51.2 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA25942.1 - 1.9e-13 50.5 0.2 9.7e-13 48.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EEA25942.1 - 5.5e-08 33.1 0.0 1.4e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 EEA25942.1 - 6.1e-05 23.3 0.1 0.00024 21.4 0.1 2.0 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EEA25942.1 - 0.012 15.6 0.0 0.039 14.0 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Gcn1_N PF12074.8 EEA25943.1 - 2.3e-119 398.9 4.3 1.3e-118 396.4 4.3 2.5 1 0 0 1 1 1 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Ribosomal_L19e PF01280.20 EEA25943.1 - 2e-60 203.0 8.1 5.3e-60 201.7 8.1 1.8 1 0 0 1 1 1 1 Ribosomal protein L19e HEAT PF02985.22 EEA25943.1 - 3.3e-25 86.0 44.8 0.32 11.4 0.0 23.7 30 0 0 30 30 24 8 HEAT repeat HEAT_EZ PF13513.6 EEA25943.1 - 2.4e-23 82.2 54.0 1.8e-06 28.3 0.0 20.0 17 4 6 23 23 22 6 HEAT-like repeat HEAT_2 PF13646.6 EEA25943.1 - 7.1e-22 77.6 48.8 0.0001 22.6 0.0 15.7 9 4 6 17 17 16 9 HEAT repeats Vac14_Fab1_bd PF12755.7 EEA25943.1 - 4.6e-11 43.2 0.1 2.8 8.6 0.0 9.1 8 3 2 10 10 9 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EEA25943.1 - 2.6e-10 40.6 7.4 0.68 10.0 0.0 9.6 8 2 0 10 10 10 3 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EEA25943.1 - 2.6e-10 40.3 0.0 1.9 8.0 0.0 7.4 6 1 1 7 7 7 4 CLASP N terminal ParcG PF10274.9 EEA25943.1 - 1.1e-07 32.2 3.6 0.11 12.6 0.0 6.2 6 1 1 7 7 7 2 Parkin co-regulated protein TIP120 PF08623.10 EEA25943.1 - 3.8e-05 23.5 5.0 0.013 15.3 0.0 6.0 6 1 0 6 6 6 1 TATA-binding protein interacting (TIP20) Adaptin_N PF01602.20 EEA25943.1 - 0.00058 18.5 6.8 0.57 8.7 0.9 6.5 6 1 1 7 7 7 1 Adaptin N terminal region DUF3385 PF11865.8 EEA25943.1 - 0.002 18.0 0.3 3.9 7.4 0.0 5.4 6 2 1 7 7 7 1 Domain of unknown function (DUF3385) DUF937 PF06078.11 EEA25943.1 - 0.012 16.2 7.7 8.9 6.9 0.0 6.1 4 2 0 4 4 4 0 Bacterial protein of unknown function (DUF937) RTP1_C1 PF10363.9 EEA25943.1 - 2.3 8.4 8.1 1.2e+02 2.9 0.0 6.0 6 0 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 SKG6 PF08693.10 EEA25944.1 - 0.0085 15.5 0.9 0.019 14.4 0.9 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 EEA25944.1 - 0.012 15.0 0.0 0.028 13.9 0.0 1.6 1 0 0 1 1 1 0 Cortical protein marker for cell polarity TMEM154 PF15102.6 EEA25944.1 - 0.11 12.3 1.5 0.54 10.2 0.3 2.6 2 1 0 2 2 2 0 TMEM154 protein family TMEM132D_C PF15706.5 EEA25944.1 - 0.16 11.8 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term EphA2_TM PF14575.6 EEA25944.1 - 0.22 12.4 0.8 0.91 10.4 0.2 2.4 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SDA1 PF05285.12 EEA25945.1 - 0.032 13.7 0.1 0.032 13.7 0.1 1.7 2 0 0 2 2 2 0 SDA1 Zn_clus PF00172.18 EEA25946.1 - 2e-10 40.6 13.6 2e-10 40.6 13.6 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EEA25947.1 - 2e-32 112.3 0.6 3.2e-32 111.6 0.2 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25947.1 - 1.6e-20 73.7 0.2 2.3e-20 73.2 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA25947.1 - 6e-08 32.8 0.0 6.1e-07 29.5 0.0 2.0 1 1 0 1 1 1 1 KR domain DUF3852 PF12963.7 EEA25947.1 - 0.11 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3852) Vac7 PF12751.7 EEA25948.1 - 5.4e-151 503.4 1.5 5.4e-151 503.4 1.5 2.7 2 1 1 3 3 3 1 Vacuolar segregation subunit 7 CorA PF01544.18 EEA25949.1 - 2.2e-37 129.0 0.8 3.5e-36 125.0 0.8 2.2 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Trp_oprn_chp PF09534.10 EEA25950.1 - 0.7 9.7 11.0 0.66 9.7 1.6 3.9 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3824 PF12868.7 EEA25951.1 - 1e-35 123.5 37.5 1e-35 123.5 37.5 7.9 4 4 5 9 9 9 4 Domain of unknwon function (DUF3824) SARAF PF06682.12 EEA25951.1 - 0.63 9.6 13.4 8.7 5.9 11.6 2.3 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Ribosomal_L44 PF00935.19 EEA25952.1 - 6.6e-37 125.8 12.6 1.1e-36 125.2 12.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Fungal_trans_2 PF11951.8 EEA25953.1 - 8.8e-09 34.6 0.6 2.7e-08 33.1 0.6 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA25953.1 - 3.8e-07 30.1 12.6 1.1e-06 28.6 12.6 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LigT_PEase PF02834.16 EEA25954.1 - 0.00016 21.8 0.0 0.044 14.0 0.0 2.6 2 1 0 2 2 2 2 LigT like Phosphoesterase TetR_C_9 PF14514.6 EEA25954.1 - 0.1 12.7 0.0 1.4 9.1 0.0 2.2 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain ubiquitin PF00240.23 EEA25955.1 - 2.3e-25 88.2 0.0 2.5e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EEA25955.1 - 3e-14 52.6 0.1 3.3e-14 52.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA25955.1 - 0.0014 19.1 0.0 0.0045 17.4 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EEA25955.1 - 0.019 14.9 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain ubiquitin PF00240.23 EEA25956.1 - 5.9e-19 67.6 0.0 6.5e-19 67.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EEA25956.1 - 4.7e-09 36.0 0.0 5.5e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA25956.1 - 0.012 16.1 0.0 0.047 14.1 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain TBK1_ULD PF18396.1 EEA25956.1 - 0.047 13.6 0.0 0.058 13.3 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Elongin_A PF06881.11 EEA25957.1 - 5.6e-28 97.5 0.3 8.1e-28 97.0 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Med3 PF11593.8 EEA25957.1 - 7.7 5.6 10.2 12 5.0 10.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal p450 PF00067.22 EEA25958.1 - 2.8e-77 260.4 0.0 3.8e-77 260.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DBD_Tnp_Mut PF03108.15 EEA25959.1 - 8.4e-10 38.5 0.3 1.4e-09 37.8 0.3 1.3 1 0 0 1 1 1 1 MuDR family transposase THOC7 PF05615.13 EEA25960.1 - 2.1e-44 151.0 7.1 2.1e-44 151.0 7.1 2.3 1 1 1 2 2 2 1 Tho complex subunit 7 Bacillus_HBL PF05791.11 EEA25960.1 - 0.034 14.0 2.6 1.7 8.4 0.1 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Mod_r PF07200.13 EEA25960.1 - 0.85 9.7 17.8 0.13 12.4 13.7 1.9 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TBCA PF02970.16 EEA25961.1 - 1.4e-25 89.4 3.3 1.8e-25 89.1 3.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A APC_N_CC PF16689.5 EEA25961.1 - 0.035 14.2 3.2 0.049 13.7 0.1 2.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain GIT_CC PF16559.5 EEA25961.1 - 0.052 13.4 1.6 1.7 8.5 0.1 2.6 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor T3SSipB PF16535.5 EEA25961.1 - 0.077 13.5 3.9 0.24 11.9 0.7 2.0 1 1 0 2 2 2 0 Type III cell invasion protein SipB Matrilin_ccoil PF10393.9 EEA25961.1 - 0.83 9.6 4.3 1.1 9.1 0.7 2.4 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin CAP_N PF01213.19 EEA25962.1 - 0.12 11.8 3.4 0.19 11.2 3.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 EEA25962.1 - 0.15 12.1 0.7 0.28 11.2 0.7 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Band_7 PF01145.25 EEA25963.1 - 3e-13 50.2 0.1 3e-13 50.2 0.1 2.0 2 0 0 2 2 2 1 SPFH domain / Band 7 family DUF743 PF05332.11 EEA25963.1 - 0.16 12.0 1.9 0.36 10.9 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF743) DDE_1 PF03184.19 EEA25964.1 - 9.1e-31 106.8 0.2 2.9e-30 105.2 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA25964.1 - 5.4e-11 42.3 1.4 8.6e-10 38.5 0.0 2.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA25964.1 - 1.1e-05 25.1 0.0 2.3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-CCHC_2 PF13696.6 EEA25964.1 - 0.098 12.5 2.0 0.17 11.7 2.0 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EEA25964.1 - 0.44 10.7 2.5 0.78 9.9 2.5 1.4 1 0 0 1 1 1 0 Zinc knuckle p450 PF00067.22 EEA25965.1 - 2.5e-24 85.9 0.1 2.8e-24 85.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_18 PF00704.28 EEA25966.1 - 5e-45 154.6 0.5 5e-45 154.6 0.5 2.0 3 0 0 3 3 3 1 Glycosyl hydrolases family 18 LysM PF01476.20 EEA25966.1 - 5e-13 48.9 0.2 3.7e-06 26.9 0.0 3.1 3 0 0 3 3 3 2 LysM domain Chitin_bind_1 PF00187.19 EEA25966.1 - 0.0001 22.7 8.9 0.0001 22.7 8.9 3.9 2 0 0 2 2 2 1 Chitin recognition protein Sigma_reg_N PF13800.6 EEA25966.1 - 0.21 11.9 0.0 1.9 8.8 0.0 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal TBCC PF07986.12 EEA25966.1 - 3.4 7.4 7.1 14 5.4 7.5 1.8 2 0 0 2 2 2 0 Tubulin binding cofactor C F-box PF00646.33 EEA25967.1 - 0.00021 21.1 0.1 0.00021 21.1 0.1 1.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EEA25967.1 - 0.0028 17.5 0.9 0.018 14.9 0.1 2.6 2 0 0 2 2 2 1 F-box-like RVT_2 PF07727.14 EEA25969.1 - 2.6e-38 132.0 0.2 4.7e-38 131.2 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA25969.1 - 1.8e-07 30.9 0.0 4.3e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_1 PF00078.27 EEA25969.1 - 0.022 14.3 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA25969.1 - 0.063 13.2 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA25969.1 - 0.1 12.9 3.2 0.26 11.6 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein REV1_C PF16727.5 EEA25970.1 - 0.036 14.4 3.5 2.1 8.8 0.3 2.4 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA25970.1 - 0.59 9.9 5.5 0.34 10.7 0.3 2.6 2 1 1 3 3 3 0 Sulfotransferase domain Sugar_tr PF00083.24 EEA25974.1 - 3.1e-78 263.7 29.3 3.7e-78 263.4 29.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA25974.1 - 2.2e-22 79.5 36.4 4.1e-19 68.7 19.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA25974.1 - 0.25 9.9 30.3 0.033 12.8 5.1 2.7 3 0 0 3 3 3 0 MFS/sugar transport protein OATP PF03137.20 EEA25974.1 - 0.39 9.0 13.1 0.14 10.4 8.4 2.5 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family FAD_binding_3 PF01494.19 EEA25975.1 - 5.6e-13 48.9 1.5 6.5e-09 35.5 0.1 2.8 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EEA25975.1 - 6e-10 38.8 0.1 0.0001 21.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA25975.1 - 2.5e-06 26.8 0.0 5.2e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA25975.1 - 7.3e-06 26.1 0.0 2.7e-05 24.3 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA25975.1 - 1.9e-05 23.6 0.1 0.0015 17.4 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EEA25975.1 - 0.00014 21.1 0.0 0.00024 20.3 0.0 1.3 1 1 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EEA25975.1 - 0.00028 21.4 0.1 0.017 15.7 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA25975.1 - 0.00061 19.2 0.0 0.00081 18.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA25975.1 - 0.0016 17.7 0.2 0.047 12.9 0.1 2.5 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA25975.1 - 0.0017 18.0 0.0 0.014 15.0 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EEA25975.1 - 0.0032 16.4 0.1 1.3 7.8 0.0 2.4 3 0 0 3 3 3 2 Tryptophan halogenase AlaDh_PNT_C PF01262.21 EEA25975.1 - 0.015 14.6 0.1 0.036 13.4 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EEA25975.1 - 0.019 14.3 0.0 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EEA25975.1 - 0.023 14.7 0.1 9.4 6.2 0.1 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EEA25975.1 - 0.077 12.0 0.0 4.2 6.3 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 EEA25975.1 - 0.18 11.0 0.1 0.34 10.1 0.1 1.4 1 0 0 1 1 1 0 Thi4 family adh_short PF00106.25 EEA25976.1 - 2.6e-25 89.0 0.4 6.3e-24 84.5 0.4 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA25976.1 - 1.7e-16 60.5 0.1 1.1e-15 57.8 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA25976.1 - 1.4e-05 25.1 0.2 2.7e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_3 PF03447.16 EEA25976.1 - 0.0045 17.6 1.7 0.011 16.4 1.7 1.7 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ATP-grasp_5 PF13549.6 EEA25976.1 - 0.022 14.2 0.1 0.033 13.6 0.1 1.2 1 0 0 1 1 1 0 ATP-grasp domain Polysacc_synt_2 PF02719.15 EEA25976.1 - 0.023 13.8 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EEA25976.1 - 0.04 14.0 0.1 0.083 13.0 0.1 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EEA25976.1 - 0.049 13.9 0.3 0.083 13.1 0.3 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain MFS_1 PF07690.16 EEA25977.1 - 2e-53 181.6 41.7 4e-52 177.3 43.0 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA25977.1 - 1.7e-14 53.2 15.7 1.7e-14 53.2 15.7 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA25977.1 - 7e-11 41.6 9.1 7e-11 41.6 9.1 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EEA25977.1 - 4.8e-06 26.1 6.1 4.8e-06 26.1 6.1 2.4 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EEA25977.1 - 0.0013 17.6 3.9 0.0013 17.6 3.9 2.8 1 1 1 2 2 2 1 MFS_1 like family OATP PF03137.20 EEA25977.1 - 0.01 14.1 13.5 0.065 11.5 10.4 2.6 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TMEM107 PF14995.6 EEA25977.1 - 2.1 8.8 6.5 0.2 12.1 0.8 2.3 3 0 0 3 3 3 0 Transmembrane protein Malic_M PF03949.15 EEA25978.1 - 3.5e-92 308.3 0.0 5.7e-92 307.6 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EEA25978.1 - 5.8e-64 215.2 0.0 1.3e-63 214.1 0.0 1.6 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DUF4449 PF14613.6 EEA25979.1 - 8.2e-06 26.0 0.4 8.2e-06 26.0 0.4 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) Ribonuc_red_lgN PF00317.21 EEA25979.1 - 0.016 15.2 0.0 0.046 13.7 0.0 1.8 1 0 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain LBP_BPI_CETP PF01273.25 EEA25979.1 - 0.032 13.8 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain DnaJ_C PF01556.18 EEA25980.1 - 7.3e-26 91.0 0.0 1.3e-25 90.2 0.0 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA25980.1 - 5.4e-25 87.3 1.5 9.5e-25 86.5 1.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EEA25980.1 - 9.6e-15 54.7 16.4 1.6e-14 54.0 16.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EEA25980.1 - 9.7e-05 22.3 9.7 0.049 13.6 1.1 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein Lar_restr_allev PF14354.6 EEA25980.1 - 0.00031 21.1 9.5 0.023 15.1 1.7 2.8 2 1 1 3 3 3 2 Restriction alleviation protein Lar HypA PF01155.19 EEA25980.1 - 0.0046 17.0 6.4 0.77 9.8 0.3 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 EEA25980.1 - 0.18 11.5 7.2 1.1 8.9 0.9 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 GRP PF07172.11 EEA25980.1 - 0.18 12.5 7.8 0.45 11.2 7.8 1.7 1 0 0 1 1 1 0 Glycine rich protein family DZR PF12773.7 EEA25980.1 - 3.4 7.8 10.4 32 4.6 10.4 2.1 1 1 0 1 1 1 0 Double zinc ribbon PBAN PF05874.11 EEA25981.1 - 0.017 15.0 0.7 0.017 15.0 0.7 1.9 2 0 0 2 2 2 0 Pheromone biosynthesis activating neuropeptide (PBAN) TFIIA PF03153.13 EEA25981.1 - 0.4 10.6 17.0 0.62 10.0 17.0 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Plasmodium_Vir PF05795.11 EEA25981.1 - 1.6 8.1 8.5 0.73 9.2 6.4 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Macoilin PF09726.9 EEA25981.1 - 1.7 7.1 13.7 2.3 6.7 13.7 1.4 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 EEA25981.1 - 2 6.7 9.2 2.8 6.2 9.2 1.2 1 0 0 1 1 1 0 Menin Ribosomal_S4 PF00163.19 EEA25982.1 - 1.8e-10 41.6 3.7 2.4e-10 41.2 3.7 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 EEA25982.1 - 5.2e-08 32.5 0.1 8.8e-08 31.7 0.1 1.4 1 0 0 1 1 1 1 S4 domain Hpr_kinase_C PF07475.12 EEA25982.1 - 0.034 13.7 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain MFS_1 PF07690.16 EEA25983.1 - 2.2e-37 128.8 25.0 3.1e-37 128.3 23.2 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA25983.1 - 3.2e-05 23.4 4.2 3.2e-05 23.4 4.2 2.6 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EEA25983.1 - 0.00039 19.4 12.4 0.00045 19.2 3.4 2.2 1 1 1 2 2 2 2 MFS_1 like family Saf_2TM PF18303.1 EEA25983.1 - 0.015 14.9 2.3 4.1 7.0 0.0 3.0 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain OMPdecase PF00215.24 EEA25984.1 - 1.3e-75 253.9 0.2 1.5e-75 253.7 0.2 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family MAPEG PF01124.18 EEA25985.1 - 8e-24 84.0 1.2 1.1e-23 83.5 1.2 1.2 1 0 0 1 1 1 1 MAPEG family MBOAT PF03062.19 EEA25986.1 - 5e-23 82.0 16.2 8.2e-23 81.3 16.2 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EEA25986.1 - 0.023 15.0 4.6 0.07 13.4 4.6 1.8 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family PTS_EIIC PF02378.18 EEA25986.1 - 0.036 13.1 4.5 0.017 14.2 1.5 1.9 2 0 0 2 2 2 0 Phosphotransferase system, EIIC WD40 PF00400.32 EEA25987.1 - 2.7e-32 110.3 34.8 8.5e-07 29.6 3.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA25987.1 - 5.7e-17 61.8 0.3 0.00021 21.5 0.0 5.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA25987.1 - 0.0026 17.6 0.3 0.85 9.5 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EEA25987.1 - 0.037 12.4 0.0 0.19 10.0 0.0 1.8 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Bacteroid_pep PF14406.6 EEA25987.1 - 0.2 12.1 0.0 0.57 10.6 0.0 1.8 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Bacteroidetes Tmemb_170 PF10190.9 EEA25988.1 - 1e-21 77.2 14.3 1.2e-21 77.0 14.3 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF294 PF03445.13 EEA25989.1 - 0.067 13.0 0.2 0.23 11.2 0.1 1.9 2 0 0 2 2 2 0 Putative nucleotidyltransferase DUF294 ICMT PF04140.14 EEA25990.1 - 9.5e-28 96.5 0.8 2e-27 95.4 0.8 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EEA25990.1 - 7.1e-12 45.7 3.8 7.1e-12 45.7 3.8 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EEA25990.1 - 0.024 14.2 3.9 0.036 13.6 3.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) DUF3180 PF11377.8 EEA25990.1 - 0.098 12.8 1.5 0.12 12.5 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) Neurensin PF14927.6 EEA25990.1 - 5.2 6.8 9.2 1.3 8.7 2.1 2.6 1 1 1 2 2 2 0 Neurensin Hexapep PF00132.24 EEA25991.1 - 2.8e-14 52.2 14.5 1.8e-11 43.3 4.1 3.2 2 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EEA25991.1 - 1.4e-12 47.1 12.7 1.1e-10 41.0 3.7 3.2 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 EEA25991.1 - 4.1e-09 36.5 0.1 7e-09 35.8 0.1 1.4 1 0 0 1 1 1 1 Maltose acetyltransferase DUF2613 PF11021.8 EEA25991.1 - 1.1 9.4 3.6 25 5.1 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) DUF3517 PF12030.8 EEA25992.1 - 1.3e-109 366.2 0.0 2.7e-109 365.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 EEA25992.1 - 7.2e-40 137.1 0.3 1.5e-39 136.0 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA25992.1 - 1.1e-21 77.8 0.5 4.2e-21 75.9 0.5 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ADD_ATRX PF17981.1 EEA25992.1 - 0.15 12.0 0.1 0.33 10.8 0.1 1.5 1 0 0 1 1 1 0 Cysteine Rich ADD domain TFIIE_alpha PF02002.17 EEA25993.1 - 2.1e-18 66.1 0.1 3.8e-18 65.3 0.1 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit HTH_Crp_2 PF13545.6 EEA25993.1 - 0.013 15.5 0.2 0.023 14.7 0.2 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TF_Zn_Ribbon PF08271.12 EEA25993.1 - 0.023 14.2 0.9 0.12 11.9 1.0 2.1 1 1 1 2 2 2 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EEA25993.1 - 0.042 14.0 0.4 0.15 12.2 0.3 1.9 1 1 1 2 2 2 0 Zinc ribbon domain HTH_Mga PF08280.11 EEA25993.1 - 0.16 12.0 0.2 0.3 11.1 0.2 1.4 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain PseudoU_synth_1 PF01416.20 EEA25994.1 - 3e-11 43.7 0.0 2.9e-09 37.3 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF4441 PF14536.6 EEA25994.1 - 0.013 15.6 2.1 0.013 15.6 2.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4441) Anillin PF08174.11 EEA25995.1 - 1.2e-08 35.5 0.0 2.4e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 EEA25995.1 - 4e-08 33.7 0.0 1.1e-07 32.2 0.0 1.9 1 0 0 1 1 1 1 PH domain DEAD PF00270.29 EEA25996.1 - 8.2e-33 113.6 0.5 2.1e-32 112.3 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA25996.1 - 1.5e-16 60.7 0.1 9.7e-15 54.9 0.4 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA25996.1 - 1.7e-06 28.2 0.0 0.067 13.2 0.0 2.6 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EEA25996.1 - 0.014 14.2 0.0 0.024 13.4 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain Inhibitor_I34 PF10466.9 EEA25996.1 - 1 10.0 5.5 4.9 7.8 0.4 2.6 2 0 0 2 2 2 0 Saccharopepsin inhibitor I34 RRM_1 PF00076.22 EEA25997.1 - 1.2e-15 57.0 0.0 1.8e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KBP_C PF12309.8 EEA25998.1 - 0.097 12.2 1.1 0.18 11.3 1.1 1.4 1 0 0 1 1 1 0 KIF-1 binding protein C terminal DUF948 PF06103.11 EEA25998.1 - 0.12 12.6 0.0 0.57 10.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GreA_GreB_N PF03449.15 EEA25998.1 - 0.13 12.4 2.1 0.5 10.6 2.1 2.0 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Rotamase PF00639.21 EEA25999.1 - 4e-22 79.0 0.1 5.9e-22 78.4 0.1 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EEA25999.1 - 1.2e-14 54.8 0.0 1.7e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EEA25999.1 - 3e-10 40.0 1.3 3e-10 40.0 1.3 1.9 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 EEA25999.1 - 0.00022 22.0 0.0 0.00032 21.5 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW_1 PF18507.1 EEA25999.1 - 0.01 15.5 0.3 0.018 14.7 0.3 1.4 1 0 0 1 1 1 0 WW domain DUF2188 PF09954.9 EEA25999.1 - 0.084 13.0 0.1 1 9.6 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) RNA_POL_M_15KD PF02150.16 EEA26000.1 - 2.5e-11 43.3 1.6 2.5e-11 43.3 1.6 3.1 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit GFA PF04828.14 EEA26000.1 - 0.0004 20.7 5.0 0.25 11.7 2.0 2.4 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EEA26000.1 - 0.0037 17.2 8.0 0.21 11.6 0.6 2.4 2 0 0 2 2 2 2 Double zinc ribbon C1_1 PF00130.22 EEA26000.1 - 0.0051 16.7 6.6 0.46 10.4 1.2 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_2 PF13240.6 EEA26000.1 - 4.6 7.1 10.2 30 4.5 4.6 3.4 2 1 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.18 EEA26001.1 - 4.6e-15 55.2 3.1 4.6e-15 55.2 3.1 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EEA26001.1 - 2.4e-11 43.3 1.6 2.4e-11 43.3 1.6 3.1 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit GFA PF04828.14 EEA26001.1 - 0.0087 16.4 9.8 0.12 12.7 0.5 2.6 1 1 2 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme Lar_restr_allev PF14354.6 EEA26001.1 - 0.048 14.1 2.4 0.048 14.1 2.4 2.3 2 1 0 2 2 2 0 Restriction alleviation protein Lar DZR PF12773.7 EEA26001.1 - 0.061 13.4 11.5 1 9.5 1.5 2.5 2 1 0 2 2 2 0 Double zinc ribbon DUF3268 PF11672.8 EEA26001.1 - 3.6 8.0 7.3 2 8.8 2.2 2.2 2 0 0 2 2 2 0 zinc-finger-containing domain RNA_POL_M_15KD PF02150.16 EEA26002.1 - 2.9e-11 43.0 1.6 2.9e-11 43.0 1.6 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EEA26002.1 - 7e-10 38.6 0.3 7e-10 38.6 0.3 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) GFA PF04828.14 EEA26002.1 - 8.5e-05 22.8 3.3 0.054 13.8 0.8 2.1 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EEA26002.1 - 0.039 14.0 5.8 6.2 6.9 5.8 2.3 1 1 0 1 1 1 0 Double zinc ribbon Lar_restr_allev PF14354.6 EEA26002.1 - 0.12 12.8 2.1 1.5 9.3 0.1 2.3 2 0 0 2 2 2 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.7 EEA26002.1 - 0.26 11.3 6.0 2.1 8.4 0.1 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain CpXC PF14353.6 EEA26002.1 - 0.68 10.0 4.2 7 6.7 0.7 2.4 2 1 0 2 2 2 0 CpXC protein zf-RRN7 PF11781.8 EEA26002.1 - 0.73 9.6 4.9 12 5.7 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Nudix_N_2 PF14803.6 EEA26002.1 - 4.2 7.4 7.5 26 4.8 3.4 2.6 2 1 0 2 2 2 0 Nudix N-terminal Ribosomal_L14 PF00238.19 EEA26003.1 - 6.9e-48 161.8 1.0 7.6e-48 161.6 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Phage_antitermQ PF06530.12 EEA26003.1 - 0.16 11.8 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q SET PF00856.28 EEA26004.1 - 2.1e-12 47.7 0.0 8.7e-09 36.0 0.0 2.8 2 0 0 2 2 2 2 SET domain SAF PF08666.12 EEA26004.1 - 0.016 15.8 0.0 3.4 8.4 0.0 2.6 2 0 0 2 2 2 0 SAF domain Tmemb_55A PF09788.9 EEA26004.1 - 2.2 7.3 4.9 0.52 9.3 0.1 2.0 2 0 0 2 2 2 0 Transmembrane protein 55A SNO PF01174.19 EEA26005.1 - 1.7e-53 181.3 0.0 1.4e-42 145.7 0.0 2.1 1 1 1 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EEA26005.1 - 6.4e-09 35.7 0.0 1.5e-07 31.2 0.0 2.2 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 EEA26005.1 - 0.00026 20.8 0.0 0.00065 19.5 0.0 1.6 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.24 EEA26005.1 - 0.0038 17.0 0.0 0.0085 15.9 0.0 1.5 2 0 0 2 2 2 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 EEA26005.1 - 0.033 13.8 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S51 ACPS PF01648.20 EEA26006.1 - 1.5e-12 47.7 0.0 4.4e-12 46.1 0.0 1.9 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Glyco_hydro_64 PF16483.5 EEA26007.1 - 4.1e-122 408.0 13.1 8.2e-78 262.2 3.3 2.0 1 1 1 2 2 2 2 Beta-1,3-glucanase Acyltransferase PF01553.21 EEA26008.1 - 1.4e-32 112.1 0.0 2.1e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Phage_holin_3_6 PF07332.11 EEA26008.1 - 0.16 12.0 2.7 0.29 11.2 2.7 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III TPR_1 PF00515.28 EEA26009.1 - 5.6e-45 149.4 24.3 8e-10 38.1 0.5 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 EEA26009.1 - 6e-41 135.3 27.9 6.8e-07 28.9 0.2 11.0 11 0 0 11 11 11 7 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA26009.1 - 3.8e-34 116.8 28.5 1.5e-25 89.2 0.6 4.9 5 0 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EEA26009.1 - 2e-29 99.3 14.4 4.1e-05 23.4 0.1 10.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 EEA26009.1 - 3.3e-26 90.7 16.5 0.00017 21.2 0.0 9.6 8 3 2 10 10 10 6 TPR repeat TPR_19 PF14559.6 EEA26009.1 - 1.5e-24 86.3 23.1 3.5e-08 33.8 0.1 8.9 6 3 1 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 EEA26009.1 - 1.6e-22 79.8 20.2 7.6e-06 26.5 0.0 8.5 6 2 2 8 8 8 7 Tetratricopeptide repeat TPR_14 PF13428.6 EEA26009.1 - 1.6e-22 78.2 17.0 0.0037 18.0 0.0 9.5 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 EEA26009.1 - 4.6e-18 65.3 20.5 0.0074 16.5 0.0 8.3 5 2 2 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 EEA26009.1 - 2.1e-16 59.0 15.3 0.039 14.3 0.0 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 EEA26009.1 - 6.1e-11 41.5 12.1 0.056 13.5 0.0 7.3 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EEA26009.1 - 8.2e-08 32.3 7.2 0.15 12.3 0.0 6.3 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EEA26009.1 - 7.2e-07 29.4 24.1 0.65 10.8 0.0 9.6 11 0 0 11 11 9 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA26009.1 - 3.2e-06 26.8 4.0 0.77 9.7 0.3 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat Sel1 PF08238.12 EEA26009.1 - 0.00027 21.5 1.2 16 6.3 0.0 5.7 6 0 0 6 6 5 0 Sel1 repeat TPR_21 PF09976.9 EEA26009.1 - 0.0017 18.1 8.5 0.2 11.4 0.9 4.2 2 1 2 4 4 4 1 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 EEA26009.1 - 0.0086 15.5 9.0 0.033 13.6 0.0 3.6 4 0 0 4 4 4 2 MalT-like TPR region ChAPs PF09295.10 EEA26009.1 - 0.12 11.4 2.0 2.7 6.9 0.2 3.1 2 1 1 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) Ribos_L4_asso_C PF14374.6 EEA26009.1 - 0.17 11.9 1.2 2.7 8.1 0.0 3.0 3 0 0 3 3 2 0 60S ribosomal protein L4 C-terminal domain TPR_4 PF07721.14 EEA26009.1 - 4.4 8.2 5.9 1.5e+02 3.4 0.2 5.2 6 0 0 6 6 4 0 Tetratricopeptide repeat TMEM208_SND2 PF05620.11 EEA26010.1 - 1.5e-55 187.6 0.1 1.6e-55 187.4 0.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Bombinin PF05298.11 EEA26011.1 - 0.23 11.1 1.1 9.2 5.9 0.0 2.8 3 0 0 3 3 3 0 Bombinin Dicty_REP PF05086.12 EEA26011.1 - 3.5 5.5 4.8 6.3 4.6 4.8 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RINGv PF12906.7 EEA26012.1 - 2.2e-16 59.7 8.9 3.7e-16 59.0 8.9 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EEA26012.1 - 0.0012 19.1 7.7 0.0021 18.4 7.7 1.4 1 0 0 1 1 1 1 Ring finger domain S1FA PF04689.13 EEA26012.1 - 0.14 12.3 0.1 0.53 10.5 0.1 2.0 1 0 0 1 1 1 0 DNA binding protein S1FA zf-RING_4 PF14570.6 EEA26012.1 - 0.44 10.4 6.6 0.73 9.7 6.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EEA26012.1 - 0.76 9.9 2.3 1.6 8.8 2.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EEA26012.1 - 3.5 7.9 5.6 7.9 6.7 5.6 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 EEA26012.1 - 4.8 7.1 4.9 9.5 6.2 4.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HeLo PF14479.6 EEA26013.1 - 0.00082 19.3 6.9 0.064 13.1 0.1 2.8 2 1 1 3 3 3 2 Prion-inhibition and propagation Pkinase_Tyr PF07714.17 EEA26013.1 - 0.13 11.5 0.1 2.2 7.5 0.0 2.2 2 0 0 2 2 2 0 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EEA26013.1 - 0.21 12.0 0.8 1.1 9.7 0.8 2.1 1 1 1 2 2 2 0 Ras-binding domain of Byr2 ACC_central PF08326.12 EEA26014.1 - 3.4e-279 928.1 0.0 4.3e-279 927.8 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EEA26014.1 - 4.6e-188 625.9 0.0 1.2e-187 624.5 0.0 1.6 2 0 0 2 2 2 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EEA26014.1 - 1.6e-54 184.7 0.0 3.3e-54 183.6 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EEA26014.1 - 3.4e-28 98.4 0.1 6.6e-28 97.5 0.1 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EEA26014.1 - 6.9e-22 77.6 0.0 7.9e-20 71.0 0.0 3.3 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EEA26014.1 - 2.5e-17 62.4 0.3 7.9e-17 60.9 0.1 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 EEA26014.1 - 0.00049 20.2 0.0 0.0018 18.3 0.0 2.0 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EEA26014.1 - 0.0013 18.3 0.1 0.0048 16.5 0.0 2.0 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EEA26014.1 - 0.0077 15.8 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain GxGYxYP_N PF16216.5 EEA26014.1 - 0.011 15.9 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal Antiterm PF03589.13 EEA26014.1 - 0.086 13.2 0.1 3.1 8.2 0.0 3.2 3 0 0 3 3 3 0 Antitermination protein His_Phos_1 PF00300.22 EEA26015.1 - 6.6e-09 35.7 0.1 2.2e-08 34.1 0.0 2.0 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) NUDE_C PF04880.13 EEA26017.1 - 6.4e-52 176.6 5.9 6.4e-52 176.6 5.9 4.1 3 2 1 4 4 2 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.12 EEA26017.1 - 0.00064 19.8 29.7 0.012 15.7 9.3 3.5 1 1 1 3 3 3 3 TPR/MLP1/MLP2-like protein ZapB PF06005.12 EEA26017.1 - 0.0019 18.6 6.4 0.0019 18.6 6.4 4.7 2 1 3 5 5 5 2 Cell division protein ZapB CENP-F_leu_zip PF10473.9 EEA26017.1 - 0.012 15.6 28.1 0.051 13.6 12.6 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SOGA PF11365.8 EEA26017.1 - 0.014 16.5 4.1 0.014 16.5 4.1 3.7 2 1 1 4 4 3 0 Protein SOGA CLZ PF16526.5 EEA26017.1 - 0.033 14.5 2.7 0.033 14.5 2.7 3.9 3 2 2 5 5 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TolA_bind_tri PF16331.5 EEA26017.1 - 0.033 14.2 1.2 0.033 14.2 1.2 3.5 1 1 2 3 3 3 0 TolA binding protein trimerisation Fez1 PF06818.15 EEA26017.1 - 0.058 13.8 23.4 1 9.7 9.5 3.1 1 1 1 2 2 2 0 Fez1 Filament PF00038.21 EEA26017.1 - 0.26 10.8 26.2 3.6 7.1 19.9 2.7 1 1 1 2 2 2 0 Intermediate filament protein AAA_13 PF13166.6 EEA26017.1 - 0.33 9.5 19.1 0.47 9.0 19.1 1.1 1 0 0 1 1 1 0 AAA domain Seryl_tRNA_N PF02403.22 EEA26017.1 - 0.43 10.8 19.7 0.13 12.4 7.2 2.8 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.7 EEA26017.1 - 0.5 10.5 29.1 1 9.5 18.2 3.5 2 1 1 3 3 3 0 Tropomyosin like ERM PF00769.19 EEA26017.1 - 0.86 9.4 28.4 4.3 7.1 27.8 2.0 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Chibby PF14645.6 EEA26017.1 - 1.3 9.4 10.2 0.36 11.2 3.4 2.6 1 1 1 2 2 2 0 Chibby family Leu_zip PF15294.6 EEA26017.1 - 1.5 8.3 21.2 0.94 8.9 7.0 2.2 1 1 1 2 2 2 0 Leucine zipper GAS PF13851.6 EEA26017.1 - 1.6 8.0 26.4 2.5 7.4 14.5 2.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EEA26017.1 - 1.6 8.9 33.3 0.53 10.5 16.9 3.0 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 EEA26017.1 - 1.7 6.1 22.4 2.3 5.6 22.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 EEA26017.1 - 2.5 8.6 36.4 13 6.3 5.7 3.2 1 1 1 2 2 2 0 Apg6 coiled-coil region GrpE PF01025.19 EEA26017.1 - 3.3 7.4 25.6 0.08 12.6 10.2 3.0 1 1 2 3 3 3 0 GrpE CENP-H PF05837.12 EEA26017.1 - 3.4 8.1 22.2 0.092 13.2 8.7 3.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FPP PF05911.11 EEA26017.1 - 4.2 5.4 23.5 2.4 6.2 15.6 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Phage_GP20 PF06810.11 EEA26017.1 - 5.6 6.8 18.0 9.3 6.0 7.2 3.2 1 1 2 3 3 3 0 Phage minor structural protein GP20 Fmp27_WPPW PF10359.9 EEA26017.1 - 5.8 5.6 15.5 0.89 8.3 7.1 2.3 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Lectin_N PF03954.14 EEA26017.1 - 6.5 6.5 10.1 8.2 6.2 3.9 3.0 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain ADIP PF11559.8 EEA26017.1 - 8 6.5 24.9 8.6 6.4 3.0 3.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 EEA26017.1 - 8.4 5.2 28.1 0.99 8.2 17.1 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF745 PF05335.13 EEA26017.1 - 8.5 6.1 10.0 18 5.0 10.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF745) PRKG1_interact PF15898.5 EEA26017.1 - 8.5 7.3 23.0 3.7 8.5 8.7 3.0 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Ank_2 PF12796.7 EEA26018.1 - 6e-283 914.4 140.8 1.4e-19 70.5 1.8 14.7 2 2 19 22 22 22 20 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA26018.1 - 1.6e-173 561.1 106.9 5.5e-11 42.8 0.8 25.6 2 2 24 27 27 27 26 Ankyrin repeats (many copies) Ank PF00023.30 EEA26018.1 - 3.2e-122 394.2 89.9 3.3e-05 24.1 0.1 30.0 26 3 4 30 30 29 27 Ankyrin repeat Ank_5 PF13857.6 EEA26018.1 - 6.9e-114 370.4 40.5 5.7e-07 29.7 0.1 27.1 2 1 27 29 29 28 27 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA26018.1 - 3.4e-112 352.7 49.6 0.0031 17.9 0.0 29.8 28 1 1 29 29 29 28 Ankyrin repeat NACHT PF05729.12 EEA26018.1 - 9.6e-11 41.9 0.3 1.8e-10 41.0 0.3 1.4 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 EEA26018.1 - 2.2e-06 27.1 0.0 3.9e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.6 EEA26018.1 - 3.9e-06 27.2 0.1 9.3e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA26018.1 - 4.8e-06 27.1 0.0 1.4e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain DUF249 PF03158.13 EEA26018.1 - 8.9e-05 22.3 7.8 23 4.6 0.1 8.3 4 3 4 10 10 10 0 Multigene family 530 protein AAA PF00004.29 EEA26018.1 - 0.0019 18.6 0.0 0.0043 17.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Nsp2a_N PF17896.1 EEA26018.1 - 0.012 14.8 0.0 1.1e+02 1.8 0.0 5.8 8 1 1 9 9 9 0 Replicase polyprotein 1a N-terminal domain NB-ARC PF00931.22 EEA26018.1 - 0.019 14.2 0.0 0.035 13.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EEA26018.1 - 0.024 15.0 0.0 0.053 13.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase G6PD_C PF02781.16 EEA26018.1 - 0.037 13.2 0.4 49 3.0 0.0 5.4 6 1 3 9 9 9 0 Glucose-6-phosphate dehydrogenase, C-terminal domain KAP_NTPase PF07693.14 EEA26018.1 - 0.058 12.6 0.0 0.2 10.8 0.0 1.7 1 1 1 2 2 2 0 KAP family P-loop domain DUF5071 PF16804.5 EEA26018.1 - 0.077 13.3 0.0 4 7.7 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5071) DUF5343 PF17278.2 EEA26018.1 - 0.12 12.4 0.2 0.29 11.2 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5343) AAA_18 PF13238.6 EEA26018.1 - 0.13 12.8 0.0 0.53 10.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EEA26018.1 - 0.13 12.3 0.0 0.68 10.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain NCD1 PF04904.13 EEA26018.1 - 1.5 8.9 15.4 1e+02 3.0 0.0 10.1 7 4 7 14 14 14 0 NAB conserved region 1 (NCD1) Isochorismatase PF00857.20 EEA26019.1 - 4.2e-45 154.1 0.0 8.9e-45 153.0 0.0 1.6 2 0 0 2 2 2 1 Isochorismatase family FAR1 PF03101.15 EEA26019.1 - 0.0047 17.6 0.0 0.0089 16.7 0.0 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.11 EEA26019.1 - 0.12 12.7 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 Transcription factor AFT Sedlin_N PF04628.13 EEA26020.1 - 9.7e-40 135.7 0.0 1.1e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EEA26020.1 - 0.00067 19.6 0.0 0.029 14.3 0.0 2.1 2 0 0 2 2 2 2 Sybindin-like family DUF2040 PF09745.9 EEA26021.1 - 6.8e-38 129.4 25.5 6.8e-38 129.4 25.5 3.7 3 1 1 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) Zip PF02535.22 EEA26022.1 - 6.8e-25 88.0 6.1 3.5e-17 62.6 0.7 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter Sporozoite_P67 PF05642.11 EEA26022.1 - 0.39 8.7 2.3 0.7 7.9 2.3 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Endonuclease_NS PF01223.23 EEA26023.1 - 1.3e-61 208.4 0.0 1.5e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease zf-RING_UBOX PF13445.6 EEA26024.1 - 6e-10 39.0 8.8 5.9e-06 26.2 3.2 2.8 2 0 0 2 2 2 2 RING-type zinc-finger zf-NOSIP PF15906.5 EEA26024.1 - 4.4e-06 26.7 0.0 1.3e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_2 PF13639.6 EEA26024.1 - 7.3e-06 26.2 12.7 0.0055 17.0 5.4 2.9 2 1 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 EEA26024.1 - 4e-05 23.5 12.9 0.00019 21.3 5.5 2.8 2 1 0 2 2 2 2 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA26024.1 - 9.8e-05 22.1 12.7 0.0016 18.2 1.4 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA26024.1 - 0.00025 20.8 3.4 0.00025 20.8 3.4 3.0 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA26024.1 - 0.00041 20.2 16.2 0.0026 17.6 2.9 2.9 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Barttin PF15462.6 EEA26024.1 - 0.0011 18.8 1.4 0.0018 18.1 1.4 1.3 1 0 0 1 1 1 1 Bartter syndrome, infantile, with sensorineural deafness (Barttin) FYVE PF01363.21 EEA26024.1 - 0.0027 17.8 9.4 0.031 14.4 3.7 3.2 2 1 0 2 2 2 1 FYVE zinc finger zf-C3HC4_5 PF17121.5 EEA26024.1 - 0.029 14.2 1.2 0.11 12.4 1.2 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA26024.1 - 2.1 8.6 13.5 0.24 11.6 2.4 3.1 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EEA26024.1 - 2.9 7.8 21.8 0.8 9.6 7.0 3.5 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 Sec7 PF01369.20 EEA26025.1 - 5.2e-34 117.5 0.3 8.3e-34 116.9 0.3 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EEA26025.1 - 3.8e-06 27.4 0.1 1e-05 26.0 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EEA26025.1 - 5.2e-06 26.8 0.1 1.4e-05 25.4 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Peptidase_M14 PF00246.24 EEA26026.1 - 5.3e-77 259.5 0.0 6.9e-77 259.1 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EEA26026.1 - 8.4e-05 22.9 0.3 8.4e-05 22.9 0.3 1.7 2 0 0 2 2 2 1 Carboxypeptidase activation peptide Mac-1 PF09028.10 EEA26026.1 - 0.088 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Mac 1 BTB PF00651.31 EEA26027.1 - 6.8e-13 48.8 0.0 5.1e-12 46.0 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain bZIP_1 PF00170.21 EEA26027.1 - 0.054 13.6 1.0 0.054 13.6 1.0 2.0 2 0 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 EEA26027.1 - 0.056 13.5 1.3 0.23 11.6 1.3 2.1 1 1 0 1 1 1 0 Basic region leucine zipper CorA PF01544.18 EEA26029.1 - 9.7e-10 38.2 0.9 1.8e-09 37.4 0.9 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein NicO PF03824.16 EEA26030.1 - 3.1e-60 203.9 11.7 7.7e-56 189.5 3.5 2.2 2 0 0 2 2 2 2 High-affinity nickel-transport protein DNA_pol_B_thumb PF14791.6 EEA26031.1 - 1.1e-20 73.5 0.2 6.2e-20 71.1 0.4 2.2 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EEA26031.1 - 1e-19 70.0 1.0 2.2e-19 69.0 1.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 EEA26031.1 - 6.6e-17 61.8 0.1 2.4e-16 60.0 0.1 2.0 1 1 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 EEA26031.1 - 6.8e-09 36.0 0.0 9.3e-08 32.3 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain BRCT_2 PF16589.5 EEA26031.1 - 0.046 14.1 0.0 0.097 13.1 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain PhoLip_ATPase_C PF16212.5 EEA26032.1 - 2.5e-82 276.4 19.0 2.5e-82 276.4 19.0 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA26032.1 - 1.1e-26 92.3 8.0 3.2e-26 90.8 8.0 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EEA26032.1 - 2.9e-11 43.3 0.0 1.4e-10 41.2 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EEA26032.1 - 5.3e-11 43.2 1.8 2.9e-06 27.7 0.2 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EEA26032.1 - 3.8e-06 26.6 0.0 8.8e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EEA26032.1 - 0.0027 17.5 0.1 0.02 14.7 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DNA_III_psi PF03603.13 EEA26032.1 - 0.12 12.7 0.1 0.29 11.4 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase III psi subunit RNase_PH PF01138.21 EEA26033.1 - 1.4e-16 61.2 0.0 2.5e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EEA26033.1 - 1e-07 31.8 0.0 1.8e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Cwf_Cwc_15 PF04889.12 EEA26034.1 - 6.4e-82 275.0 13.8 7.5e-82 274.8 13.8 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 EEA26034.1 - 0.044 13.2 16.8 0.049 13.0 16.8 1.1 1 0 0 1 1 1 0 SDA1 PA26 PF04636.13 EEA26034.1 - 0.25 10.2 4.1 0.28 10.0 4.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Nop53 PF07767.11 EEA26034.1 - 2.3 7.5 22.4 3.1 7.1 22.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Hid1 PF12722.7 EEA26034.1 - 5.8 4.9 6.5 6.7 4.7 6.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med22 PF06179.12 EEA26035.1 - 4.9e-19 68.5 0.1 6e-19 68.2 0.1 1.0 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex DHFR_1 PF00186.19 EEA26036.1 - 5.9e-21 74.8 0.1 3.5e-10 39.8 0.0 3.4 1 1 1 2 2 2 2 Dihydrofolate reductase Voltage_CLC PF00654.20 EEA26037.1 - 4.1e-88 296.0 21.9 4.1e-88 296.0 21.9 2.2 2 1 0 2 2 2 1 Voltage gated chloride channel Arteri_Gl PF00951.18 EEA26037.1 - 0.29 10.9 5.0 0.076 12.8 1.3 1.9 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein Lipase_GDSL_2 PF13472.6 EEA26038.1 - 7.6e-24 85.1 0.0 1.4e-23 84.2 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EEA26038.1 - 2.2e-18 67.0 0.0 2.9e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase FlaC_arch PF05377.11 EEA26039.1 - 0.00022 21.5 1.6 0.0012 19.1 1.6 2.3 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.12 EEA26039.1 - 0.0045 17.0 0.5 0.01 15.9 0.5 1.7 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Atg14 PF10186.9 EEA26039.1 - 0.0097 15.0 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 MtrG PF04210.13 EEA26039.1 - 0.013 15.3 0.0 0.048 13.5 0.0 1.9 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G FliD_C PF07195.12 EEA26039.1 - 0.022 14.2 0.3 0.04 13.3 0.3 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF1664 PF07889.12 EEA26039.1 - 0.026 14.6 0.3 0.065 13.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HSBP1 PF06825.12 EEA26039.1 - 0.026 14.4 2.1 0.27 11.1 1.2 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Prefoldin_3 PF13758.6 EEA26039.1 - 0.031 14.3 1.4 0.031 14.3 1.4 2.4 3 1 0 3 3 3 0 Prefoldin subunit DUF948 PF06103.11 EEA26039.1 - 0.15 12.3 0.2 0.4 11.0 0.2 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EEA26039.1 - 0.4 11.2 5.4 2.1 8.9 3.8 2.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 EEA26039.1 - 2.3 8.5 7.5 0.67 10.2 2.7 2.6 2 1 1 3 3 3 0 Haemolysin XhlA Isochorismatase PF00857.20 EEA26041.1 - 2.5e-30 106.0 0.1 3.1e-30 105.6 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family HK PF02110.15 EEA26042.1 - 1.8e-71 240.4 0.6 1.8e-71 240.4 0.6 1.8 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EEA26042.1 - 8.4e-57 191.4 3.2 8.4e-57 191.4 3.2 1.7 2 0 0 2 2 2 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 EEA26042.1 - 9e-05 22.0 1.5 0.00031 20.2 0.1 2.4 2 1 0 2 2 2 1 Phosphomethylpyrimidine kinase eIF-5_eIF-2B PF01873.17 EEA26043.1 - 2.9e-39 133.6 0.0 5.1e-39 132.8 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EEA26043.1 - 3.4e-21 75.1 0.6 9.2e-21 73.8 0.0 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon MutL PF13941.6 EEA26044.1 - 0.0016 17.1 0.5 0.0031 16.2 0.5 1.4 1 0 0 1 1 1 1 MutL protein U3snoRNP10 PF12397.8 EEA26044.1 - 0.1 12.9 11.1 1.6 9.1 1.1 4.5 4 1 0 4 4 4 0 U3 small nucleolar RNA-associated protein 10 DUF1981 PF09324.10 EEA26044.1 - 0.18 11.7 2.7 3.2 7.7 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) Sec7_N PF12783.7 EEA26044.1 - 0.22 11.4 1.9 2.4 8.1 0.0 3.3 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DNA_ligase_A_M PF01068.21 EEA26045.1 - 1.3e-60 204.6 0.2 1.9e-47 161.6 0.2 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EEA26045.1 - 6.5e-45 153.6 0.0 1.3e-44 152.6 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EEA26045.1 - 4.3e-28 97.8 0.0 1.5e-27 96.1 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EEA26045.1 - 2.4e-05 24.7 0.1 3.8e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 RNA ligase Synaptonemal_3 PF15191.6 EEA26045.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 mRNA_cap_enzyme PF01331.19 EEA26046.1 - 1.1e-55 188.5 1.0 1.6e-55 187.9 1.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EEA26046.1 - 5e-36 123.6 0.2 1.2e-35 122.4 0.2 1.6 2 0 0 2 2 2 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EEA26046.1 - 8e-10 38.7 0.1 9e-07 28.7 0.4 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EEA26046.1 - 0.0021 18.4 0.7 0.0035 17.7 0.1 1.7 2 0 0 2 2 2 1 RNA ligase SCA7 PF08313.12 EEA26047.1 - 4.6e-31 106.5 1.3 1.4e-30 105.0 1.3 1.9 1 0 0 1 1 1 1 SCA7, zinc-binding domain CDC45 PF02724.14 EEA26047.1 - 0.12 10.6 11.2 0.17 10.1 11.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 EEA26047.1 - 0.13 10.9 6.1 0.17 10.5 6.1 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Cut8 PF08559.10 EEA26047.1 - 0.18 11.4 3.1 0.74 9.4 3.1 2.1 1 1 0 1 1 1 0 Cut8, nuclear proteasome tether protein DNA_pol_phi PF04931.13 EEA26047.1 - 2.3 6.2 9.3 3.8 5.5 9.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi SCA7 PF08313.12 EEA26048.1 - 5.3e-31 106.3 1.3 1.6e-30 104.8 1.3 1.9 1 0 0 1 1 1 1 SCA7, zinc-binding domain CDC45 PF02724.14 EEA26048.1 - 0.14 10.4 11.2 0.2 9.9 11.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 EEA26048.1 - 0.15 10.6 6.2 0.2 10.2 6.2 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Cut8 PF08559.10 EEA26048.1 - 0.21 11.2 3.0 0.82 9.2 3.0 2.0 1 1 0 1 1 1 0 Cut8, nuclear proteasome tether protein DNA_pol_phi PF04931.13 EEA26048.1 - 2.6 6.0 9.3 4.3 5.3 9.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi ketoacyl-synt PF00109.26 EEA26049.1 - 1e-59 202.2 4.3 2e-58 198.0 0.5 2.1 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EEA26049.1 - 3.7e-31 107.6 0.9 7.3e-31 106.6 0.9 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EEA26049.1 - 3.4e-05 23.4 0.4 0.001 18.5 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA26049.1 - 0.00019 21.1 2.0 0.0045 16.6 0.5 2.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain Arginase PF00491.21 EEA26050.1 - 1.8e-91 306.5 0.0 2.2e-91 306.2 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EEA26050.1 - 0.01 16.1 0.0 0.016 15.4 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain Ras PF00071.22 EEA26051.1 - 8.8e-53 178.2 0.0 1e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA26051.1 - 6.9e-19 68.2 0.0 9.4e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA26051.1 - 3.1e-06 26.7 0.0 4.2e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EEA26052.1 - 1.6e-52 177.4 0.0 2.1e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA26052.1 - 6.4e-19 68.3 0.0 8.6e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA26052.1 - 1.7e-06 27.6 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EEA26053.1 - 8.8e-53 178.2 0.0 1e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA26053.1 - 6.9e-19 68.2 0.0 9.4e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA26053.1 - 3.1e-06 26.7 0.0 4.2e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MFS_1 PF07690.16 EEA26054.1 - 6.4e-22 78.0 33.2 1e-20 74.0 32.4 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA26054.1 - 1.2e-07 30.6 18.7 2e-07 29.8 18.6 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1349 PF07081.11 EEA26055.1 - 3.7e-30 105.0 0.0 4.5e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) DUF2040 PF09745.9 EEA26056.1 - 0.14 12.2 0.1 0.14 12.2 0.1 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) GRDP-like PF07173.12 EEA26058.1 - 4.5e-21 76.0 0.2 1.5e-16 61.4 0.0 3.0 2 2 0 2 2 2 2 Glycine-rich domain-containing protein-like YqcI_YcgG PF08892.11 EEA26058.1 - 0.23 11.3 1.8 15 5.3 0.0 2.6 3 0 0 3 3 3 0 YqcI/YcgG family Iwr1 PF08574.10 EEA26061.1 - 1.4e-22 80.5 7.8 1.4e-22 80.5 7.8 3.1 3 0 0 3 3 3 1 Transcription factor Iwr1 GET2 PF08690.10 EEA26061.1 - 0.3 10.7 1.5 0.56 9.8 1.5 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 Nup_retrotrp_bd PF10599.9 EEA26061.1 - 2 9.1 8.0 26 5.6 0.2 2.7 1 1 1 2 2 2 0 Retro-transposon transporting motif RRM_1 PF00076.22 EEA26062.1 - 1.6e-38 130.4 0.1 7.1e-12 45.0 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA26062.1 - 2.3e-15 56.2 0.0 0.0013 18.5 0.0 4.3 4 0 0 4 4 4 3 Occluded RNA-recognition motif RRM PF10378.9 EEA26062.1 - 4.5e-07 29.5 1.6 3e-06 26.8 1.6 2.5 1 0 0 1 1 1 1 Putative RRM domain RRM_7 PF16367.5 EEA26062.1 - 2.2e-06 27.7 0.0 0.0034 17.5 0.0 3.5 3 0 0 3 3 3 1 RNA recognition motif DUF4523 PF15023.6 EEA26062.1 - 3.6e-06 26.9 0.0 0.012 15.4 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF4523) RRM_3 PF08777.11 EEA26062.1 - 0.00012 22.1 0.1 0.22 11.6 0.1 3.0 3 0 0 3 3 3 2 RNA binding motif Spo7_2_N PF15407.6 EEA26062.1 - 0.025 14.2 0.0 0.96 9.1 0.0 2.7 2 0 0 2 2 2 0 Sporulation protein family 7 RRM_Rrp7 PF17799.1 EEA26062.1 - 0.028 14.2 0.0 1.6 8.5 0.0 3.3 2 1 1 3 3 3 0 Rrp7 RRM-like N-terminal domain RNA_bind PF08675.11 EEA26062.1 - 0.043 13.8 0.3 0.22 11.6 0.0 2.4 3 0 0 3 3 3 0 RNA binding domain tRNA-synt_2 PF00152.20 EEA26063.1 - 1.6e-88 296.8 0.0 2.4e-88 296.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA26063.1 - 1.9e-08 34.1 0.0 3.6e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 EEA26063.1 - 0.064 13.5 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain MC1 PF05854.11 EEA26063.1 - 0.14 12.5 1.0 0.32 11.3 0.4 1.9 2 0 0 2 2 2 0 Non-histone chromosomal protein MC1 Ecl1 PF12855.7 EEA26064.1 - 4.4e-40 138.7 57.5 6.1e-40 138.2 33.1 3.1 2 1 0 2 2 2 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 EEA26064.1 - 0.01 15.9 3.5 0.029 14.4 3.5 1.7 1 0 0 1 1 1 0 MYND finger zf-FLZ PF04570.14 EEA26064.1 - 0.38 10.3 5.7 1.6 8.2 5.7 1.9 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF2256 PF10013.9 EEA26064.1 - 1 9.5 6.3 7.8 6.7 6.3 2.1 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) YL1 PF05764.13 EEA26065.1 - 3.5e-64 217.3 32.6 3.5e-64 217.3 32.6 3.1 2 1 1 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 EEA26065.1 - 2.6e-08 33.5 0.1 4.5e-08 32.7 0.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain PUF PF00806.19 EEA26066.1 - 2.5e-27 93.0 0.0 4.2e-05 23.0 0.0 6.1 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EEA26066.1 - 2.3e-10 40.1 0.0 5.1e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ham1p_like PF01725.16 EEA26067.1 - 4.2e-46 157.2 0.0 4.9e-46 157.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DcpS PF05652.12 EEA26068.1 - 3.7e-36 124.1 0.0 5.9e-36 123.5 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EEA26068.1 - 2e-29 102.4 0.0 4e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding UDG PF03167.19 EEA26068.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Uracil DNA glycosylase superfamily Peptidase_C12 PF01088.21 EEA26069.1 - 6.4e-53 179.6 0.0 7.8e-53 179.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 MT-A70 PF05063.14 EEA26070.1 - 9.8e-22 77.7 0.0 1.8e-21 76.8 0.0 1.5 1 0 0 1 1 1 1 MT-A70 RNase_H2_suC PF08615.11 EEA26070.1 - 4.4e-13 49.6 0.0 2.7e-09 37.3 0.0 2.4 1 1 1 2 2 2 2 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Cons_hypoth95 PF03602.15 EEA26070.1 - 0.21 11.2 0.0 0.38 10.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Amidohydro_3 PF07969.11 EEA26071.1 - 1.1e-37 130.6 1.0 2.8e-37 129.3 1.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EEA26071.1 - 8.6e-13 48.3 1.3 6.8e-09 35.5 0.0 3.1 3 0 0 3 3 3 2 Amidohydrolase family DUF3197 PF11432.8 EEA26071.1 - 0.16 11.9 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3197) RNase_T PF00929.24 EEA26072.1 - 3.7e-20 73.1 0.0 7.4e-20 72.1 0.0 1.5 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EEA26072.1 - 0.12 12.1 0.0 0.43 10.3 0.0 1.9 1 1 0 1 1 1 0 3'-5' exonuclease Nop53 PF07767.11 EEA26073.1 - 3.9e-105 352.5 39.0 5.2e-105 352.1 39.0 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Myb_Cef PF11831.8 EEA26074.1 - 5e-52 176.9 2.9 5e-52 176.9 2.9 4.0 4 0 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EEA26074.1 - 1.1e-21 76.8 4.5 7.5e-11 42.1 0.7 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA26074.1 - 2.2e-20 72.6 3.3 1.9e-13 50.4 0.7 3.2 2 1 1 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EEA26074.1 - 0.016 15.2 1.0 0.22 11.6 0.0 3.2 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MOZ_SAS PF01853.18 EEA26075.1 - 4.6e-80 267.5 0.0 6.5e-80 267.0 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EEA26075.1 - 1.8e-22 78.7 0.5 3.9e-22 77.6 0.5 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EEA26075.1 - 4.9e-20 71.2 0.1 1.1e-19 70.1 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EEA26075.1 - 0.0024 18.3 0.0 0.0051 17.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA26075.1 - 0.059 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Agenet PF05641.12 EEA26075.1 - 0.071 13.6 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Agenet domain FR47 PF08445.10 EEA26075.1 - 0.18 11.8 0.0 0.44 10.5 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein MOZ_SAS PF01853.18 EEA26076.1 - 3.8e-80 267.8 0.0 5.3e-80 267.3 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EEA26076.1 - 1.6e-22 78.9 0.5 3.5e-22 77.8 0.5 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EEA26076.1 - 5.7e-11 42.1 0.6 1.3e-10 41.0 0.6 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EEA26076.1 - 0.0022 18.4 0.0 0.0043 17.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA26076.1 - 0.051 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family FR47 PF08445.10 EEA26076.1 - 0.17 11.9 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Ferlin_C PF16165.5 EEA26076.1 - 9 6.2 6.8 0.27 11.2 0.1 1.9 3 0 0 3 3 3 0 Ferlin C-terminus F1F0-ATPsyn_F PF10791.9 EEA26078.1 - 2.4e-43 146.5 0.1 2.7e-43 146.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 EEA26078.1 - 0.011 16.1 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f ETC_C1_NDUFA4 PF04800.12 EEA26079.1 - 6.2e-36 122.5 1.0 8.7e-36 122.1 1.0 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region HEAT_2 PF13646.6 EEA26080.1 - 1.9e-30 105.1 3.2 8.6e-15 54.9 1.0 3.5 2 2 2 4 4 4 2 HEAT repeats HEAT_PBS PF03130.16 EEA26080.1 - 3.4e-22 76.8 0.1 0.0016 18.9 0.3 6.3 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 EEA26080.1 - 1.5e-10 40.4 1.6 0.28 11.6 0.0 6.2 7 0 0 7 7 7 3 HEAT repeat Cnd1 PF12717.7 EEA26080.1 - 0.00041 20.4 0.0 0.61 10.1 0.0 3.3 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EEA26080.1 - 0.00066 20.1 7.4 3.4 8.3 0.0 5.4 5 3 3 8 8 8 1 HEAT-like repeat Arm PF00514.23 EEA26080.1 - 0.0048 16.9 0.4 0.16 12.1 0.0 3.3 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Cohesin_HEAT PF12765.7 EEA26080.1 - 0.01 16.1 0.0 0.46 10.8 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion TFIIS_C PF01096.18 EEA26081.1 - 2.8e-13 49.5 3.3 2.8e-13 49.5 3.3 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EEA26081.1 - 7.1e-06 25.8 6.4 1.2e-05 25.1 0.2 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit CxC7 PF18866.1 EEA26081.1 - 0.024 14.8 1.7 1.8 8.7 0.1 3.1 2 1 1 3 3 3 0 CxC7 like cysteine cluster associated with KDZ transposases PNP_UDP_1 PF01048.20 EEA26081.1 - 0.092 12.0 0.0 0.11 11.7 0.0 1.3 1 1 0 1 1 1 0 Phosphorylase superfamily Ribosomal_S27e PF01667.17 EEA26081.1 - 0.28 10.9 4.1 5.6 6.8 0.0 3.1 2 1 1 3 3 3 0 Ribosomal protein S27 Zn_ribbon_recom PF13408.6 EEA26081.1 - 0.33 11.5 11.1 7.7 7.1 0.9 3.2 2 1 1 3 3 3 0 Recombinase zinc beta ribbon domain YhfH PF14149.6 EEA26081.1 - 0.44 10.6 5.6 16 5.6 0.1 3.2 3 0 0 3 3 3 0 YhfH-like protein DZR PF12773.7 EEA26081.1 - 0.44 10.6 10.5 0.21 11.6 0.8 2.5 1 1 2 3 3 3 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EEA26081.1 - 0.47 10.2 12.9 2.1 8.1 0.1 3.7 4 0 0 4 4 4 0 zinc-ribbon domain zf-trcl PF13451.6 EEA26081.1 - 2.7 7.9 10.4 1.6 8.7 1.4 3.4 3 1 0 3 3 3 0 Probable zinc-ribbon domain DNA_RNApol_7kD PF03604.13 EEA26081.1 - 6.2 6.6 13.4 5.3 6.8 0.2 3.8 3 1 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-ribbon_3 PF13248.6 EEA26081.1 - 8.7 5.9 10.5 12 5.4 0.0 3.6 4 0 0 4 4 4 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EEA26081.1 - 9.4 6.2 8.6 22 5.1 0.7 2.8 2 2 1 3 3 3 0 Putative transposase DNA-binding domain Nipped-B_C PF12830.7 EEA26082.1 - 7.5e-47 159.7 3.9 2.9e-45 154.6 0.7 3.3 2 1 1 3 3 3 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EEA26082.1 - 1.6e-11 44.3 6.9 7.2e-11 42.2 3.2 3.4 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Cnd3 PF12719.7 EEA26082.1 - 5.6e-05 22.5 1.0 0.014 14.6 0.0 3.2 2 1 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.7 EEA26082.1 - 0.00025 21.1 0.3 0.0017 18.4 0.1 2.5 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EEA26082.1 - 0.011 14.3 6.3 0.052 12.1 3.1 3.3 4 1 1 5 5 5 0 Adaptin N terminal region HEAT PF02985.22 EEA26082.1 - 0.059 13.7 12.2 1.3 9.5 0.4 5.9 7 0 0 7 7 7 0 HEAT repeat Archaeal_AmoA PF12942.7 EEA26082.1 - 0.16 11.6 0.2 0.31 10.7 0.2 1.3 1 0 0 1 1 1 0 Archaeal ammonia monooxygenase subunit A (AmoA) Tom22 PF04281.13 EEA26082.1 - 0.22 11.3 1.6 0.59 9.9 1.6 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Pyr_redox_2 PF07992.14 EEA26083.1 - 5.2e-43 147.4 0.0 6.9e-43 147.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA26083.1 - 1.3e-11 44.8 0.0 6e-10 39.5 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EEA26083.1 - 4.2e-07 29.1 0.2 1.2e-06 27.6 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EEA26083.1 - 1.4e-05 24.6 0.4 4.1e-05 23.2 0.4 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EEA26083.1 - 2.3e-05 24.8 0.6 6.6e-05 23.3 0.5 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EEA26083.1 - 0.00044 19.6 0.2 0.00089 18.6 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EEA26083.1 - 0.015 15.1 0.1 0.043 13.7 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair Pyr_redox_3 PF13738.6 EEA26083.1 - 0.026 13.8 2.3 0.43 9.8 1.8 2.4 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CLTH PF10607.9 EEA26084.1 - 5.7e-34 117.1 0.1 7.2e-34 116.8 0.1 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EEA26084.1 - 5.9e-09 35.6 0.0 1.1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 LisH CLTH PF10607.9 EEA26085.1 - 6.8e-34 116.9 0.1 8.8e-34 116.5 0.1 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EEA26085.1 - 6.9e-09 35.3 0.0 1.3e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 LisH CLTH PF10607.9 EEA26086.1 - 5.4e-34 117.2 0.1 6.8e-34 116.9 0.1 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EEA26086.1 - 5.7e-09 35.6 0.0 1.1e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 LisH CLTH PF10607.9 EEA26087.1 - 5.5e-34 117.2 0.1 7e-34 116.8 0.1 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EEA26087.1 - 6.1e-09 35.5 0.0 1.1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 LisH PRK PF00485.18 EEA26088.1 - 1.7e-58 197.6 0.0 2.8e-58 196.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 EEA26088.1 - 2.8e-43 147.8 0.1 4.5e-43 147.1 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 EEA26088.1 - 5.3e-06 27.0 0.0 1.4e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 EEA26088.1 - 0.004 17.0 0.0 0.0097 15.8 0.0 1.6 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 EEA26088.1 - 0.0063 15.8 0.0 0.016 14.5 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 EEA26088.1 - 0.01 16.2 1.2 0.18 12.2 0.2 2.9 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EEA26088.1 - 0.011 15.9 0.0 0.024 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EEA26088.1 - 0.018 15.0 0.0 0.55 10.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EEA26088.1 - 0.02 15.4 0.1 0.74 10.3 0.1 2.3 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 EEA26088.1 - 0.036 14.4 0.0 0.16 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Pribosyltran PF00156.27 EEA26088.1 - 0.042 13.4 0.0 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosyl transferase domain DUF87 PF01935.17 EEA26088.1 - 0.053 13.6 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA PF00004.29 EEA26088.1 - 0.082 13.3 0.0 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 EEA26088.1 - 0.088 12.9 0.1 0.2 11.7 0.1 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Cytidylate_kin2 PF13189.6 EEA26088.1 - 0.13 12.4 0.6 1.1 9.3 0.1 2.4 2 1 0 2 2 2 0 Cytidylate kinase-like family NUC153 PF08159.12 EEA26089.1 - 6.3e-15 54.7 0.9 6.3e-15 54.7 0.9 3.6 3 0 0 3 3 3 1 NUC153 domain Eaf7 PF07904.13 EEA26089.1 - 0.006 16.9 2.6 0.006 16.9 2.6 5.0 4 1 1 5 5 5 2 Chromatin modification-related protein EAF7 FNIP_N PF14636.6 EEA26090.1 - 2e-33 116.5 0.1 2e-33 116.5 0.1 4.2 3 1 1 4 4 4 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.6 EEA26090.1 - 0.12 12.3 0.2 1.9 8.4 0.0 2.5 2 1 1 3 3 3 0 Folliculin-interacting protein middle domain IML1 PF12257.8 EEA26091.1 - 7.5e-111 369.8 0.0 1.2e-110 369.2 0.0 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EEA26091.1 - 9.6e-26 89.6 0.3 1.9e-25 88.7 0.3 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Na_Ca_ex PF01699.24 EEA26092.1 - 1.3e-44 151.8 36.9 2.7e-24 85.8 16.3 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3270 PF11674.8 EEA26092.1 - 0.14 12.3 0.5 1.1 9.5 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) DUF4337 PF14235.6 EEA26092.1 - 0.22 11.6 1.8 3.5 7.7 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Oxidored_FMN PF00724.20 EEA26093.1 - 0.00059 19.2 0.0 0.00064 19.1 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family adh_short PF00106.25 EEA26094.1 - 2.5e-40 138.0 0.0 3.7e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA26094.1 - 6.6e-30 104.4 0.1 9.6e-30 103.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA26094.1 - 3.8e-11 43.2 0.6 2.9e-10 40.3 0.6 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA26094.1 - 5.9e-05 22.7 0.0 9e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EEA26094.1 - 0.003 17.8 0.1 0.0058 16.9 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain UPF0146 PF03686.13 EEA26094.1 - 0.0036 17.2 0.1 0.0091 15.9 0.0 1.6 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0146) NAD_binding_10 PF13460.6 EEA26094.1 - 0.008 16.1 0.2 0.044 13.7 0.1 2.0 2 0 0 2 2 2 1 NAD(P)H-binding Wax2_C PF12076.8 EEA26094.1 - 0.012 15.4 0.0 0.034 13.8 0.0 1.8 2 0 0 2 2 2 0 WAX2 C-terminal domain CheW PF01584.19 EEA26094.1 - 0.022 14.4 0.0 0.072 12.7 0.0 1.7 2 0 0 2 2 2 0 CheW-like domain 3Beta_HSD PF01073.19 EEA26094.1 - 0.11 11.5 0.1 0.16 10.9 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1776 PF08643.10 EEA26094.1 - 0.11 11.8 0.0 0.55 9.6 0.0 1.9 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) p450 PF00067.22 EEA26095.1 - 2.3e-56 191.5 0.0 2.6e-56 191.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EEA26096.1 - 2.5e-34 118.8 0.0 3.3e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ubie_methyltran PF01209.18 EEA26097.1 - 1.3e-77 260.2 0.0 2e-77 259.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EEA26097.1 - 4e-16 59.5 0.0 1.5e-15 57.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA26097.1 - 2e-14 54.0 0.0 1.4e-13 51.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA26097.1 - 7.6e-12 45.3 0.0 1.5e-11 44.3 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA26097.1 - 2.3e-10 41.1 0.0 4e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA26097.1 - 7.3e-07 29.2 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EEA26097.1 - 0.015 15.2 0.0 0.085 12.7 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase SIS PF01380.22 EEA26098.1 - 8.6e-12 45.0 0.0 2.3e-11 43.7 0.0 1.8 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EEA26098.1 - 2.3e-05 24.4 0.1 0.0018 18.3 0.1 2.6 1 1 1 2 2 2 2 SIS domain DDE_1 PF03184.19 EEA26099.1 - 5e-24 84.9 0.0 1e-23 83.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA26099.1 - 9.9e-09 35.1 0.3 3.3e-08 33.4 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA26099.1 - 0.0087 16.2 0.1 0.18 12.0 0.0 2.7 3 0 0 3 3 3 1 Transcription factor Pcc1 Amidase PF01425.21 EEA26099.1 - 0.071 12.1 1.4 0.11 11.4 1.4 1.2 1 0 0 1 1 1 0 Amidase Glyco_hydro_62 PF03664.13 EEA26100.1 - 2.1e-126 420.8 9.0 2.8e-126 420.4 9.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 CBM_1 PF00734.18 EEA26100.1 - 1.3e-10 41.1 16.7 1.3e-10 41.1 16.7 2.0 2 0 0 2 2 2 1 Fungal cellulose binding domain DUF3439 PF11921.8 EEA26100.1 - 3.3 7.7 11.8 8.6 6.3 11.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Peptidase_S9 PF00326.21 EEA26101.1 - 1.1e-06 28.3 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EEA26101.1 - 2.8e-06 27.2 0.2 5.9e-06 26.1 0.2 1.5 1 1 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 EEA26101.1 - 1.7e-05 24.4 0.0 2.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase MetallophosN PF16371.5 EEA26101.1 - 0.0046 17.2 0.0 0.0088 16.3 0.0 1.4 1 0 0 1 1 1 1 N terminal of Calcineurin-like phosphoesterase Abhydrolase_2 PF02230.16 EEA26101.1 - 0.014 15.2 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EEA26101.1 - 0.033 13.8 0.1 0.048 13.3 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 EEA26101.1 - 0.072 11.8 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Rhomboid_SP PF12595.8 EEA26101.1 - 0.16 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Rhomboid serine protease CTP_transf_like PF01467.26 EEA26102.1 - 4.2e-22 78.9 0.0 6e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like HECT PF00632.25 EEA26103.1 - 3.5e-73 246.8 0.0 9e-73 245.4 0.0 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Arm PF00514.23 EEA26103.1 - 7.4e-05 22.6 7.4 0.041 13.9 0.2 6.0 5 1 1 6 6 6 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EEA26103.1 - 0.00011 22.2 0.7 0.065 13.5 0.2 4.4 3 0 0 3 3 3 1 HEAT repeat RIX1 PF08167.12 EEA26103.1 - 0.0033 17.2 0.2 0.45 10.2 0.1 3.3 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis HEAT_EZ PF13513.6 EEA26103.1 - 0.0041 17.6 0.1 0.04 14.4 0.1 2.7 2 0 0 2 2 2 1 HEAT-like repeat UNC45-central PF11701.8 EEA26103.1 - 0.0092 16.0 0.7 7.6 6.5 0.0 3.6 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central Adaptin_N PF01602.20 EEA26103.1 - 0.013 14.1 0.1 0.064 11.8 0.0 2.2 2 0 0 2 2 2 0 Adaptin N terminal region HEAT_2 PF13646.6 EEA26103.1 - 0.031 14.7 0.0 9.8 6.6 0.0 3.4 2 0 0 2 2 2 0 HEAT repeats Granulin PF00396.18 EEA26104.1 - 0.00034 20.9 2.9 0.00034 20.9 2.9 2.5 2 1 0 2 2 2 2 Granulin Chitin_bind_1 PF00187.19 EEA26104.1 - 7 7.2 22.2 0.51 10.9 12.1 2.3 1 1 1 2 2 2 0 Chitin recognition protein FMO-like PF00743.19 EEA26105.1 - 6.2e-29 100.8 0.0 2.1e-18 66.0 0.0 3.4 3 1 1 4 4 4 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA26105.1 - 6.9e-10 38.7 3.5 5.1e-06 26.0 0.2 3.3 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA26105.1 - 6.5e-06 25.6 0.5 0.0004 19.7 1.1 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA26105.1 - 1.6e-05 25.0 0.1 0.00017 21.7 0.3 2.9 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EEA26105.1 - 6.4e-05 23.1 0.1 0.00016 21.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA26105.1 - 0.00036 20.2 3.9 0.032 13.8 1.7 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EEA26105.1 - 0.0035 16.5 0.6 0.065 12.4 0.0 2.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Semialdhyde_dh PF01118.24 EEA26105.1 - 0.092 13.2 0.0 0.91 10.0 0.0 2.5 4 0 0 4 4 4 0 Semialdehyde dehydrogenase, NAD binding domain Thi4 PF01946.17 EEA26105.1 - 0.099 11.9 0.6 0.25 10.6 0.2 1.7 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 EEA26105.1 - 0.22 10.2 1.3 0.37 9.4 1.3 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 EEA26105.1 - 0.22 10.5 0.6 0.32 10.0 0.6 1.2 1 0 0 1 1 1 0 FAD binding domain MSC PF09402.10 EEA26106.1 - 1.7e-99 333.5 0.0 2.5e-99 333.0 0.0 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EEA26106.1 - 3.6e-17 61.8 0.0 6.5e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 HeH/LEM domain Endonuc-dimeris PF09124.10 EEA26106.1 - 0.031 14.4 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation PP2C PF00481.21 EEA26107.1 - 1.2e-52 179.1 0.1 2.7e-52 178.0 0.0 1.7 2 0 0 2 2 2 1 Protein phosphatase 2C LRR_8 PF13855.6 EEA26107.1 - 2.9e-35 119.8 58.3 4.5e-10 39.1 1.2 11.1 4 4 6 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 EEA26107.1 - 1.9e-31 107.5 57.7 0.00021 21.6 0.2 11.7 8 3 1 11 11 11 9 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EEA26107.1 - 7.7e-28 97.3 0.0 1.7e-27 96.2 0.0 1.5 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ad_cyc_g-alpha PF08509.11 EEA26107.1 - 1e-12 47.6 0.2 4e-12 45.7 0.2 2.1 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_9 PF14580.6 EEA26107.1 - 4.2e-08 32.9 13.7 0.0037 16.8 0.4 4.8 2 1 4 6 6 6 5 Leucine-rich repeat LRR_5 PF13306.6 EEA26107.1 - 7.6e-08 32.4 2.9 1.6 8.7 0.2 5.2 5 0 0 5 5 5 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EEA26107.1 - 5.5e-05 23.2 51.1 2.3 9.1 0.0 14.9 16 0 0 16 16 16 2 Leucine Rich Repeat Glyco_hydro_16 PF00722.21 EEA26108.1 - 1.3e-41 142.0 3.6 2e-41 141.4 3.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 CBM26 PF16738.5 EEA26108.1 - 1.7 8.9 7.4 0.5 10.7 0.2 3.1 3 0 0 3 3 3 0 Starch-binding module 26 MIP PF00230.20 EEA26109.1 - 3.7e-25 89.0 3.4 4.3e-25 88.8 3.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein FGGY_C PF02782.16 EEA26110.1 - 3.8e-74 248.7 0.4 6.1e-74 248.0 0.4 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EEA26110.1 - 7.9e-68 228.6 0.0 1.1e-67 228.2 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Methyltransf_23 PF13489.6 EEA26111.1 - 8.8e-21 74.4 0.0 1.4e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA26111.1 - 1.3e-07 32.2 0.0 4.5e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA26111.1 - 1e-06 28.6 0.0 3.1e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 EEA26111.1 - 4.5e-06 26.2 0.0 1.3e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_11 PF08241.12 EEA26111.1 - 0.00011 22.7 0.0 0.00035 21.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA26111.1 - 0.00012 22.8 0.0 0.0012 19.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EEA26111.1 - 0.00038 19.5 0.0 0.23 10.4 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1698) MTS PF05175.14 EEA26111.1 - 0.0011 18.6 0.0 0.0031 17.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 EEA26111.1 - 0.0041 16.4 0.0 0.0077 15.6 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 EEA26111.1 - 0.052 13.7 0.0 0.086 12.9 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EEA26111.1 - 0.1 11.9 0.0 0.32 10.3 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family DnaJ PF00226.31 EEA26112.1 - 2.3e-19 69.3 0.8 5.8e-19 68.0 0.8 1.8 1 0 0 1 1 1 1 DnaJ domain zf-CCHC_6 PF15288.6 EEA26112.1 - 0.00093 19.0 0.7 0.0024 17.7 0.7 1.6 1 0 0 1 1 1 1 Zinc knuckle MULE PF10551.9 EEA26112.1 - 0.0039 17.6 0.0 0.011 16.1 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain RRM_1 PF00076.22 EEA26112.1 - 0.012 15.4 0.2 0.035 13.9 0.2 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_10 PF16588.5 EEA26112.1 - 0.023 14.4 1.9 0.048 13.4 1.9 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger MCR PF18509.1 EEA26112.1 - 0.22 11.2 1.3 0.42 10.2 1.3 1.5 1 0 0 1 1 1 0 Magnetochrome domain LDB19 PF13002.7 EEA26113.1 - 2e-53 181.0 0.1 3.5e-53 180.2 0.1 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EEA26113.1 - 6.5e-09 36.0 0.0 4.4e-08 33.3 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain TYA PF01021.19 EEA26114.1 - 0.18 12.1 1.3 0.37 11.1 1.2 1.5 1 1 0 1 1 1 0 TYA transposon protein Transp_cyt_pur PF02133.15 EEA26115.1 - 3.8e-98 329.1 32.8 4.7e-98 328.8 32.8 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin WD40 PF00400.32 EEA26116.1 - 4.6e-28 96.9 10.7 1.8e-06 28.5 0.2 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26116.1 - 5.7e-07 29.8 0.1 1.4 9.3 0.0 4.8 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA26116.1 - 0.0011 18.0 0.0 0.5 9.3 0.0 2.5 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EEA26116.1 - 0.023 13.3 4.2 2.6 6.6 0.0 3.5 3 1 1 4 4 4 0 Nucleoporin Nup120/160 PD40 PF07676.12 EEA26116.1 - 0.065 13.2 0.7 89 3.2 0.0 4.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat SRP9-21 PF05486.12 EEA26117.1 - 3.4e-32 110.7 2.2 3.4e-32 110.7 2.2 1.7 2 0 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) Ank_2 PF12796.7 EEA26118.1 - 2.5e-26 92.1 0.5 1.3e-13 51.3 0.1 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA26118.1 - 3.5e-12 46.3 0.0 1e-08 35.2 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA26118.1 - 4.7e-12 46.2 0.0 9.5e-10 38.8 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA26118.1 - 3.8e-11 42.2 0.0 2.5e-05 24.3 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EEA26118.1 - 1.8e-10 40.8 0.1 1.9e-07 31.2 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat bZIP_Maf PF03131.17 EEA26118.1 - 0.088 13.3 8.8 0.15 12.6 8.8 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Herpes_UL6 PF01763.16 EEA26118.1 - 0.1 11.1 0.6 0.19 10.2 0.6 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like GTP_EFTU PF00009.27 EEA26120.1 - 7.9e-20 71.2 0.0 1.8e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EEA26120.1 - 2e-08 34.5 1.9 1.1e-07 32.1 1.3 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EEA26120.1 - 4.5e-05 23.7 0.0 0.00016 22.0 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain PduV-EutP PF10662.9 EEA26120.1 - 0.002 17.9 0.3 2.2 8.0 0.1 3.3 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EEA26120.1 - 0.011 15.8 0.1 0.028 14.5 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA26120.1 - 0.015 15.2 0.1 4.6 7.1 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 EEA26120.1 - 0.06 13.4 0.3 0.36 10.9 0.1 2.2 2 0 0 2 2 2 0 Dynamin family Roc PF08477.13 EEA26120.1 - 0.069 13.4 0.1 2.7 8.2 0.1 2.7 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase LSM PF01423.22 EEA26121.1 - 7.2e-19 67.3 0.3 9.7e-19 66.8 0.3 1.2 1 0 0 1 1 1 1 LSM domain SH3_9 PF14604.6 EEA26121.1 - 1.7 8.6 4.2 5.3 7.0 0.0 2.8 3 0 0 3 3 3 0 Variant SH3 domain ATP13 PF12921.7 EEA26122.1 - 2.8e-19 69.1 0.0 1.3e-18 66.9 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial ATPase expression PPR_3 PF13812.6 EEA26122.1 - 1.5e-08 34.5 0.0 1e-06 28.7 0.0 2.5 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 EEA26122.1 - 5.9e-06 26.4 0.0 8.4e-05 22.7 0.0 2.5 2 0 0 2 2 2 1 PPR repeat family PIG-L PF02585.17 EEA26123.1 - 3.6e-31 108.5 0.1 5.2e-31 108.0 0.1 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase PIG-L PF02585.17 EEA26124.1 - 3.6e-31 108.5 0.1 5.2e-31 108.0 0.1 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Fungal_trans_2 PF11951.8 EEA26125.1 - 1.9e-15 56.6 6.8 1.7e-13 50.1 0.2 2.8 2 1 0 2 2 2 2 Fungal specific transcription factor domain 2OG-FeII_Oxy_3 PF13640.6 EEA26126.1 - 0.028 15.3 0.0 0.048 14.5 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Ax_dynein_light PF10211.9 EEA26127.1 - 0.05 13.5 1.8 0.13 12.2 1.8 1.7 1 0 0 1 1 1 0 Axonemal dynein light chain DASH_Spc19 PF08287.11 EEA26127.1 - 0.072 13.0 9.8 0.048 13.6 7.1 2.1 2 0 0 2 2 2 0 Spc19 Cnd1_N PF12922.7 EEA26127.1 - 1.7 8.4 7.9 0.64 9.8 0.8 2.6 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1, N-term Amidohydro_2 PF04909.14 EEA26128.1 - 2.8e-25 89.7 0.0 3.7e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase Ferritin_2 PF13668.6 EEA26129.1 - 4.2e-14 52.9 0.0 6.7e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain DUF3658 PF12395.8 EEA26129.1 - 0.073 13.0 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function OHCU_decarbox PF09349.10 EEA26130.1 - 9.7e-46 156.1 0.0 1.1e-45 155.9 0.0 1.0 1 0 0 1 1 1 1 OHCU decarboxylase DMAP1 PF05499.12 EEA26132.1 - 3.7 7.4 8.6 0.51 10.2 3.9 1.9 2 0 0 2 2 2 0 DNA methyltransferase 1-associated protein 1 (DMAP1) TruB_N PF01509.18 EEA26133.1 - 1e-45 155.7 0.2 1.5e-44 152.0 0.0 2.7 3 1 1 4 4 4 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EEA26133.1 - 5.5e-06 26.4 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Baculo_PP31 PF05311.11 EEA26133.1 - 0.077 12.5 0.0 0.18 11.2 0.0 1.6 1 1 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Smg8_Smg9 PF10220.9 EEA26133.1 - 0.34 9.1 3.0 0.46 8.7 3.0 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Arc_C PF18162.1 EEA26134.1 - 0.032 14.1 0.0 0.083 12.8 0.0 1.7 1 0 0 1 1 1 0 Arc C-lobe DNMT1-RFD PF12047.8 EEA26134.1 - 0.04 13.9 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain HpaP PF09483.10 EEA26134.1 - 0.069 13.4 0.2 0.56 10.5 0.0 2.4 2 0 0 2 2 2 0 Type III secretion protein (HpaP) Ebp2 PF05890.12 EEA26135.1 - 2e-95 319.4 16.9 2e-95 319.4 16.9 2.0 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 PNISR PF15996.5 EEA26135.1 - 7.8 6.7 31.7 0.42 10.9 18.1 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR HSBP1 PF06825.12 EEA26136.1 - 8.1e-20 70.4 0.0 1e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Matrilin_ccoil PF10393.9 EEA26136.1 - 0.0023 17.8 0.1 0.0089 15.9 0.1 1.8 1 1 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin NPV_P10 PF05531.12 EEA26136.1 - 0.0066 16.9 0.0 0.01 16.3 0.0 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 EEA26136.1 - 0.051 13.6 0.0 0.062 13.3 0.0 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Thioredoxin PF00085.20 EEA26137.1 - 1.1e-61 205.2 0.1 1.5e-30 105.2 0.0 2.5 3 0 0 3 3 3 2 Thioredoxin ERp29 PF07749.12 EEA26137.1 - 2.7e-24 85.9 0.2 5.2e-24 85.0 0.2 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EEA26137.1 - 4e-22 78.7 0.5 1.1e-09 38.7 0.0 3.0 3 1 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EEA26137.1 - 1.1e-15 57.7 0.0 8.1e-07 28.7 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EEA26137.1 - 4.2e-12 46.2 0.3 0.00011 22.4 0.0 4.4 3 2 1 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EEA26137.1 - 4.2e-11 42.9 0.0 6.1e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EEA26137.1 - 9.5e-11 41.7 0.0 0.00053 19.9 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family TraF PF13728.6 EEA26137.1 - 1.2e-06 28.5 0.0 0.021 14.6 0.0 2.3 2 0 0 2 2 2 2 F plasmid transfer operon protein ERp29_N PF07912.13 EEA26137.1 - 2.3e-05 24.5 0.0 0.0062 16.7 0.0 2.3 2 0 0 2 2 2 1 ERp29, N-terminal domain HyaE PF07449.11 EEA26137.1 - 2.6e-05 24.1 0.0 0.035 14.1 0.0 2.5 2 0 0 2 2 2 2 Hydrogenase-1 expression protein HyaE Redoxin PF08534.10 EEA26137.1 - 3.3e-05 23.6 0.5 0.18 11.5 0.1 2.5 2 1 0 2 2 2 2 Redoxin Thioredoxin_3 PF13192.6 EEA26137.1 - 0.00021 21.3 0.0 0.082 13.0 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_9 PF14595.6 EEA26137.1 - 0.00023 21.0 0.0 0.35 10.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Glutaredoxin PF00462.24 EEA26137.1 - 0.00081 19.6 1.0 1.9 8.8 0.1 3.1 2 2 0 2 2 2 2 Glutaredoxin Thioredoxin_4 PF13462.6 EEA26137.1 - 0.004 17.3 1.5 5.3 7.2 0.1 3.3 3 2 2 5 5 5 2 Thioredoxin DUF836 PF05768.14 EEA26137.1 - 0.012 16.0 0.0 0.18 12.2 0.0 2.4 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) DSBA PF01323.20 EEA26137.1 - 0.038 13.7 1.3 11 5.7 0.0 3.6 3 2 2 5 5 5 0 DSBA-like thioredoxin domain MKT1_C PF12246.8 EEA26138.1 - 2.6e-76 256.0 0.0 4.4e-76 255.3 0.0 1.4 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EEA26138.1 - 2.5e-30 104.7 0.0 7e-30 103.2 0.0 1.8 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EEA26138.1 - 1.8e-06 28.3 0.0 9.9e-06 26.0 0.0 2.2 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EEA26138.1 - 0.00045 20.5 0.0 0.0011 19.3 0.0 1.5 1 0 0 1 1 1 1 XPG I-region 2OG-FeII_Oxy PF03171.20 EEA26139.1 - 1.5e-16 60.7 0.0 1.1e-14 54.8 0.0 2.6 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EEA26139.1 - 1.1e-13 52.0 0.0 1.8e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal WD40 PF00400.32 EEA26140.1 - 1.6e-39 133.1 19.4 1.3e-05 25.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26140.1 - 7.1e-16 58.3 0.0 0.00032 20.9 0.1 5.2 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA26140.1 - 0.00013 21.9 0.0 0.15 12.0 0.0 2.6 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EEA26140.1 - 0.0018 17.6 0.0 0.059 12.7 0.0 2.9 2 1 1 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 EEA26140.1 - 0.047 12.6 0.2 21 4.0 0.0 3.6 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SelP_N PF04592.14 EEA26141.1 - 0.068 12.6 12.0 0.086 12.2 12.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Innate_immun PF12782.7 EEA26141.1 - 0.078 12.5 8.9 0.096 12.2 8.9 1.1 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family zf-MYND PF01753.18 EEA26142.1 - 7.3e-08 32.4 19.2 1.6e-07 31.3 19.2 1.6 1 0 0 1 1 1 1 MYND finger Na_Ca_ex PF01699.24 EEA26143.1 - 9.4e-31 106.8 41.4 2e-15 57.0 20.6 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF872 PF05915.12 EEA26143.1 - 0.055 13.6 0.0 0.3 11.3 0.0 2.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Phosducin PF02114.16 EEA26144.1 - 3.5e-12 45.9 0.2 1.4e-10 40.6 0.0 2.4 2 1 0 2 2 2 1 Phosducin Clathrin_lg_ch PF01086.17 EEA26144.1 - 0.029 14.4 5.9 0.04 14.0 5.9 1.1 1 0 0 1 1 1 0 Clathrin light chain Phosducin PF02114.16 EEA26145.1 - 8.8e-13 47.8 0.1 3.7e-11 42.5 0.0 2.4 2 1 0 2 2 2 1 Phosducin Clathrin_lg_ch PF01086.17 EEA26145.1 - 0.031 14.3 5.9 0.042 13.9 5.9 1.1 1 0 0 1 1 1 0 Clathrin light chain YEATS PF03366.16 EEA26146.1 - 3.4e-19 68.6 0.0 8.4e-19 67.3 0.0 1.7 2 0 0 2 2 2 1 YEATS family BET PF17035.5 EEA26146.1 - 1.6e-06 28.2 0.1 2.9e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation YEATS PF03366.16 EEA26147.1 - 3.4e-19 68.6 0.0 8.3e-19 67.3 0.0 1.7 2 0 0 2 2 2 1 YEATS family BET PF17035.5 EEA26147.1 - 1.6e-06 28.2 0.1 2.9e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Ran_BP1 PF00638.18 EEA26148.1 - 8e-49 165.0 1.6 1.3e-48 164.3 1.6 1.3 1 0 0 1 1 1 1 RanBP1 domain VID27_PH PF17747.1 EEA26148.1 - 0.00028 21.2 0.0 0.00039 20.7 0.0 1.2 1 0 0 1 1 1 1 VID27 PH-like domain WH1 PF00568.23 EEA26148.1 - 0.00032 20.6 0.2 0.0017 18.3 0.2 1.9 1 1 0 1 1 1 1 WH1 domain DDE_1 PF03184.19 EEA26149.1 - 4.9e-24 84.9 0.0 1e-23 83.9 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA26149.1 - 1.9e-08 34.2 0.3 6.5e-08 32.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Amidase PF01425.21 EEA26149.1 - 0.042 12.8 1.6 0.065 12.2 1.6 1.2 1 0 0 1 1 1 0 Amidase Pcc1 PF09341.10 EEA26149.1 - 0.065 13.4 0.1 1.3 9.2 0.0 2.7 3 0 0 3 3 3 0 Transcription factor Pcc1 FAD_binding_3 PF01494.19 EEA26150.1 - 1e-08 34.9 0.0 1.1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain zf-CpG_bind_C PF12269.8 EEA26151.1 - 0.026 14.3 0.3 0.043 13.6 0.3 1.4 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Prominin PF05478.11 EEA26151.1 - 0.15 10.0 0.3 0.24 9.3 0.3 1.2 1 0 0 1 1 1 0 Prominin DHR10 PF18595.1 EEA26151.1 - 0.35 10.9 3.3 0.7 10.0 3.3 1.5 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Peptidase_C2 PF00648.21 EEA26152.1 - 7e-64 215.7 1.1 3.4e-44 151.1 0.4 2.2 2 0 0 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.22 EEA26152.1 - 0.16 12.2 1.8 0.66 10.2 0.0 2.7 3 0 0 3 3 3 0 Calpain large subunit, domain III DUF5526 PF17664.1 EEA26152.1 - 1.7 8.2 17.1 1.3 8.6 14.9 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5526) Glyco_hydro_43 PF04616.14 EEA26153.1 - 1.1e-49 169.3 3.1 1.4e-49 168.9 3.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF2510 PF10708.9 EEA26153.1 - 9.4 6.1 8.5 0.51 10.2 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) Abhydrolase_3 PF07859.13 EEA26154.1 - 4.9e-06 26.6 0.0 0.00021 21.2 0.0 2.8 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EEA26154.1 - 0.0018 18.0 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA26154.1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF2653 PF10850.8 EEA26155.1 - 0.079 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2653) Cation_efflux PF01545.21 EEA26156.1 - 1.2e-51 175.2 7.6 1.6e-51 174.8 7.6 1.2 1 0 0 1 1 1 1 Cation efflux family BPD_transp_2 PF02653.16 EEA26156.1 - 0.0017 17.6 0.2 0.0017 17.6 0.2 2.0 3 0 0 3 3 3 1 Branched-chain amino acid transport system / permease component GerA PF03323.13 EEA26156.1 - 0.1 11.0 0.7 0.21 10.0 0.7 1.4 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein B-block_TFIIIC PF04182.12 EEA26157.1 - 0.079 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Pkinase PF00069.25 EEA26158.1 - 5.3e-73 245.6 0.0 8.2e-73 245.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26158.1 - 2.4e-30 105.7 0.0 3.1e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA26158.1 - 5.7e-05 22.6 0.0 0.00017 21.0 0.0 1.7 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EEA26158.1 - 0.00018 20.6 0.0 0.012 14.6 0.0 2.1 2 0 0 2 2 2 2 Haspin like kinase domain APH PF01636.23 EEA26158.1 - 0.0035 17.3 0.1 0.0084 16.1 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EEA26158.1 - 0.011 14.8 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.25 EEA26159.1 - 9.7e-69 231.7 0.0 1.7e-68 230.9 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26159.1 - 1.8e-27 96.3 0.0 2.5e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA26159.1 - 9.8e-05 21.8 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EEA26159.1 - 0.0013 17.8 0.1 0.013 14.4 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EEA26159.1 - 0.0045 16.9 0.0 0.0076 16.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EEA26159.1 - 0.013 14.6 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 2OG-FeII_Oxy_2 PF13532.6 EEA26160.1 - 1.6e-29 103.5 0.0 2.3e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DivIC PF04977.15 EEA26161.1 - 0.82 9.5 4.6 0.47 10.3 1.3 2.2 2 0 0 2 2 2 0 Septum formation initiator TolA_bind_tri PF16331.5 EEA26161.1 - 0.87 9.7 8.1 0.11 12.6 2.4 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation zf-C2H2_4 PF13894.6 EEA26161.1 - 1.1 10.3 3.2 0.74 10.8 0.7 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA26161.1 - 6.3 7.5 5.9 1.4 9.5 0.6 2.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type Acyl-CoA_dh_1 PF00441.24 EEA26162.1 - 1.6e-32 112.8 1.2 3e-32 111.9 1.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EEA26162.1 - 2.7e-21 75.6 0.0 5.7e-21 74.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EEA26162.1 - 8.4e-21 74.7 0.1 1.7e-20 73.7 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EEA26162.1 - 3.3e-14 53.3 1.7 3.3e-14 53.3 1.7 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_1 PF00441.24 EEA26163.1 - 1.3e-32 113.1 1.2 2.3e-32 112.3 1.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EEA26163.1 - 2.5e-21 75.6 0.0 4.6e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EEA26163.1 - 6.6e-21 75.1 0.1 1.4e-20 74.1 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EEA26163.1 - 2.6e-14 53.7 1.7 2.6e-14 53.7 1.7 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Gly_transf_sug PF04488.15 EEA26164.1 - 2.4e-13 50.6 0.1 5.3e-13 49.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif ABC2_membrane PF01061.24 EEA26165.1 - 5.3e-49 166.5 21.3 5.3e-49 166.5 21.3 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EEA26165.1 - 1.5e-37 129.1 0.2 7.3e-18 65.4 0.0 2.9 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EEA26165.1 - 6.1e-29 99.8 0.0 1.7e-28 98.4 0.0 1.8 1 0 0 1 1 1 1 CDR ABC transporter ABC_trans_N PF14510.6 EEA26165.1 - 3.2e-10 40.5 0.2 1.2e-09 38.6 0.2 2.1 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_21 PF13304.6 EEA26165.1 - 5.3e-06 26.5 0.0 0.051 13.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EEA26165.1 - 1.9e-05 25.1 1.8 0.00051 20.5 0.1 2.9 3 0 0 3 3 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA26165.1 - 2e-05 24.6 0.3 7.2e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EEA26165.1 - 3.2e-05 23.6 0.1 0.00084 19.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain ABC2_membrane_3 PF12698.7 EEA26165.1 - 0.00055 19.2 20.3 0.0011 18.2 20.3 1.5 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_33 PF13671.6 EEA26165.1 - 0.00059 20.0 1.1 0.015 15.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EEA26165.1 - 0.00074 19.2 0.1 0.11 12.2 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EEA26165.1 - 0.001 19.0 0.1 0.032 14.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EEA26165.1 - 0.0018 18.5 0.4 0.6 10.4 0.1 3.1 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA26165.1 - 0.0032 18.0 1.2 0.19 12.3 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EEA26165.1 - 0.0072 16.1 0.1 0.16 11.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EEA26165.1 - 0.0091 15.6 0.1 0.21 11.2 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EEA26165.1 - 0.015 15.8 0.0 0.35 11.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EEA26165.1 - 0.017 14.5 0.3 4.6 6.5 0.1 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_28 PF13521.6 EEA26165.1 - 0.033 14.5 2.0 0.048 13.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EEA26165.1 - 0.051 14.1 1.5 2 8.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EEA26165.1 - 0.065 12.3 0.7 0.28 10.2 0.0 2.3 3 0 0 3 3 3 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EEA26165.1 - 0.11 12.6 0.8 3.7 7.7 0.3 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rad17 PF03215.15 EEA26165.1 - 0.16 11.9 0.0 16 5.4 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain TMIE PF16038.5 EEA26165.1 - 0.3 10.9 0.8 1.1 9.1 0.8 2.0 1 0 0 1 1 1 0 TMIE protein Sid-5 PF17204.3 EEA26167.1 - 0.0033 17.5 0.8 0.0036 17.4 0.8 1.0 1 0 0 1 1 1 1 Sid-5 family Bac_transf PF02397.16 EEA26167.1 - 0.0065 16.1 0.1 0.0069 16.0 0.1 1.0 1 0 0 1 1 1 1 Bacterial sugar transferase FtsL PF04999.13 EEA26167.1 - 0.019 14.9 0.2 0.019 14.9 0.2 1.0 1 0 0 1 1 1 0 Cell division protein FtsL CcmE PF03100.15 EEA26167.1 - 0.11 12.4 0.2 0.12 12.4 0.2 1.0 1 0 0 1 1 1 0 CcmE OppC_N PF12911.7 EEA26167.1 - 0.12 12.3 2.6 0.14 12.1 2.6 1.2 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Tad PF13400.6 EEA26167.1 - 1.2 9.5 5.7 1.4 9.3 5.7 1.1 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like FeoB_associated PF12669.7 EEA26167.1 - 2.2 8.8 6.1 3.1 8.3 6.1 1.5 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein RRM_1 PF00076.22 EEA26169.1 - 1.3e-18 66.5 0.0 2e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trnau1ap PF17654.1 EEA26169.1 - 0.19 12.6 3.5 0.35 11.8 3.5 1.4 1 0 0 1 1 1 0 Selenocysteine tRNA 1 associated proteins 6PGD PF00393.19 EEA26170.1 - 1.7e-127 424.8 0.0 2e-127 424.5 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EEA26170.1 - 2.5e-49 167.5 0.0 3.6e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA26170.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase AD PF09793.9 EEA26171.1 - 1.6e-28 98.6 0.0 2.7e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain Glyco_hydro_15 PF00723.21 EEA26172.1 - 2.2e-18 66.3 0.0 1.4e-14 53.7 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Glyco_hydro_15 PF00723.21 EEA26173.1 - 8.2e-19 67.7 0.0 1.4e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 TPT PF03151.16 EEA26174.1 - 3.6e-21 75.8 15.8 4.4e-21 75.5 15.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA26174.1 - 1.9e-07 31.3 32.4 0.0011 19.1 10.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 EEA26174.1 - 3.4e-05 23.2 15.1 5.1e-05 22.7 15.1 1.2 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport REV PF00424.18 EEA26174.1 - 0.065 13.3 3.1 0.14 12.2 3.1 1.5 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) AP_endonuc_2 PF01261.24 EEA26175.1 - 1e-28 100.3 0.0 1.5e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Prismane PF03063.20 EEA26175.1 - 0.56 8.8 4.5 1 7.9 4.5 1.4 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Mad3_BUB1_I PF08311.12 EEA26176.1 - 1.2e-44 151.2 0.7 2.3e-44 150.3 0.2 1.7 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 EEA26176.1 - 2.1e-14 53.4 0.0 3.8e-13 49.4 0.0 2.6 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 EEA26176.1 - 5.7e-08 32.4 0.0 4.9e-07 29.4 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain Mad3_BUB1_I_2 PF17014.5 EEA26176.1 - 0.007 16.5 0.0 0.025 14.7 0.0 1.9 2 0 0 2 2 2 1 Putative Mad3/BUB1 like region 1 protein Peptidase_C15 PF01470.17 EEA26178.1 - 6.8e-11 42.7 0.1 0.0055 16.9 0.0 3.1 2 1 0 2 2 2 2 Pyroglutamyl peptidase MOSC PF03473.17 EEA26179.1 - 1.1e-31 109.6 0.0 1.6e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EEA26179.1 - 2.3e-22 79.1 0.0 3.7e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain DNA_pol_phi PF04931.13 EEA26180.1 - 8.2e-252 837.7 18.4 8.2e-252 837.7 18.4 1.4 2 0 0 2 2 2 1 DNA polymerase phi SDA1 PF05285.12 EEA26180.1 - 0.00015 21.3 23.3 0.00015 21.3 23.3 1.9 2 0 0 2 2 2 1 SDA1 SEO_N PF14576.6 EEA26180.1 - 0.0042 16.3 1.3 0.008 15.4 0.1 2.1 2 0 0 2 2 2 1 Sieve element occlusion N-terminus Cnd3 PF12719.7 EEA26180.1 - 0.0052 16.0 0.1 0.053 12.7 0.0 2.6 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain Nop14 PF04147.12 EEA26180.1 - 0.01 14.1 25.6 0.024 12.9 25.6 1.6 1 0 0 1 1 1 0 Nop14-like family Phage_holin_2_3 PF16080.5 EEA26180.1 - 0.036 13.8 0.1 0.081 12.7 0.1 1.5 1 0 0 1 1 1 0 Bacteriophage holin family HP1 CDC45 PF02724.14 EEA26180.1 - 0.064 11.6 13.4 0.14 10.5 13.4 1.6 1 0 0 1 1 1 0 CDC45-like protein TAN PF11640.8 EEA26180.1 - 0.87 9.7 5.2 1 9.5 0.6 3.1 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair BUD22 PF09073.10 EEA26180.1 - 1.9 7.8 32.4 0.081 12.3 25.2 2.3 3 0 0 3 3 3 0 BUD22 RRN3 PF05327.11 EEA26180.1 - 2.4 6.6 20.9 6.8 5.1 20.9 1.8 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TNT PF14021.6 EEA26181.1 - 4.9e-25 87.9 0.0 1e-24 86.9 0.0 1.5 1 0 0 1 1 1 1 Tuberculosis necrotizing toxin SAP30_Sin3_bdg PF13867.6 EEA26182.1 - 0.92 9.9 2.7 1.4 9.3 0.1 2.2 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 NADH-u_ox-rdase PF10785.9 EEA26183.1 - 0.53 11.0 2.8 5.8 7.7 0.0 3.5 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Histone PF00125.24 EEA26184.1 - 1.3e-35 122.6 0.4 1.6e-35 122.3 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EEA26184.1 - 0.00058 20.0 0.2 0.00086 19.4 0.2 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EEA26184.1 - 0.0058 17.0 0.6 0.0095 16.3 0.6 1.3 1 0 0 1 1 1 1 CENP-S protein SH3_17 PF18350.1 EEA26186.1 - 0.041 13.8 0.1 0.066 13.1 0.1 1.3 1 0 0 1 1 1 0 Restriction endonuclease SH3 domain Methyltransf_2 PF00891.18 EEA26187.1 - 6.1e-21 74.7 0.0 8.5e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain AMP-binding PF00501.28 EEA26188.1 - 5.2e-55 186.8 0.0 1.9e-54 184.9 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme Thioesterase PF00975.20 EEA26188.1 - 2.6e-28 99.7 0.0 9.7e-28 97.8 0.0 1.9 1 1 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 EEA26188.1 - 1.2e-09 38.3 0.0 2.9e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.7 EEA26188.1 - 0.0029 18.2 0.1 0.007 17.0 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA26188.1 - 0.0064 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA26188.1 - 0.042 13.1 0.0 0.31 10.3 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 NAD_binding_2 PF03446.15 EEA26189.1 - 3e-27 95.7 0.0 4.9e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA26189.1 - 8.3e-06 26.0 0.9 6.8e-05 23.1 0.5 2.5 2 1 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EEA26189.1 - 6e-05 23.1 0.0 0.00014 22.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EEA26189.1 - 0.001 19.6 0.0 0.0026 18.3 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EEA26189.1 - 0.025 13.9 0.0 0.13 11.6 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh PF00984.19 EEA26189.1 - 0.092 13.0 0.0 2 8.7 0.0 2.3 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Cu-oxidase_3 PF07732.15 EEA26190.1 - 9.6e-44 148.2 3.9 4.3e-43 146.1 0.9 2.7 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EEA26190.1 - 2.5e-34 118.7 1.1 1.2e-32 113.2 0.0 2.6 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EEA26190.1 - 2.2e-31 108.4 6.3 6e-26 90.8 0.5 4.0 3 1 0 3 3 3 3 Multicopper oxidase Rhodanese PF00581.20 EEA26191.1 - 4.1e-14 53.0 0.1 1.1e-13 51.6 0.0 1.7 2 0 0 2 2 2 1 Rhodanese-like domain Sld5 PF05916.11 EEA26192.1 - 2.4e-12 47.3 0.6 3.8e-12 46.6 0.6 1.4 1 1 0 1 1 1 1 GINS complex protein SLD5_C PF16922.5 EEA26192.1 - 1.2e-08 35.0 3.0 2.4e-08 34.0 3.0 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus UBM PF14377.6 EEA26192.1 - 0.043 13.3 0.5 0.18 11.3 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin binding region Cullin PF00888.22 EEA26193.1 - 8.3e-205 682.0 12.1 8.3e-205 682.0 12.1 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EEA26193.1 - 7.4e-26 90.0 1.8 1.7e-25 88.8 0.2 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain zf-DNL PF05180.12 EEA26194.1 - 2.1e-27 94.8 0.6 3.4e-27 94.2 0.6 1.3 1 0 0 1 1 1 1 DNL zinc finger Zn-ribbon_8 PF09723.10 EEA26194.1 - 0.019 15.1 0.8 0.036 14.2 0.8 1.4 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 EEA26194.1 - 0.021 14.7 0.4 0.15 12.0 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.18 EEA26194.1 - 0.021 14.6 1.0 1.3 8.9 0.2 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-CSL PF05207.13 EEA26194.1 - 0.024 14.3 0.2 0.043 13.5 0.2 1.4 1 0 0 1 1 1 0 CSL zinc finger zf-RING_7 PF02591.15 EEA26194.1 - 0.033 14.4 0.3 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 C4-type zinc ribbon domain HypA PF01155.19 EEA26194.1 - 0.11 12.5 0.2 0.17 11.9 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1 PF03811.13 EEA26194.1 - 0.17 11.7 0.4 0.17 11.7 0.4 2.1 3 0 0 3 3 3 0 InsA N-terminal domain DRIM PF07539.12 EEA26195.1 - 2.4e-188 627.3 0.1 2.4e-188 627.3 0.1 3.7 5 1 0 5 5 5 1 Down-regulated in metastasis HEAT_EZ PF13513.6 EEA26195.1 - 0.013 16.0 0.2 0.27 11.8 0.0 3.5 3 0 0 3 3 3 0 HEAT-like repeat HEAT PF02985.22 EEA26195.1 - 0.015 15.5 0.5 24 5.5 0.0 5.9 5 0 0 5 5 5 0 HEAT repeat BLM10_mid PF16507.5 EEA26195.1 - 0.13 10.9 3.0 0.16 10.6 0.2 2.5 2 0 0 2 2 2 0 Proteasome-substrate-size regulator, mid region CwfJ_C_1 PF04677.15 EEA26196.1 - 1.5e-22 79.7 0.0 2.5e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EEA26196.1 - 8.4e-14 52.3 0.1 1.5e-13 51.4 0.1 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Corona_S2 PF01601.16 EEA26198.1 - 1.5 7.2 14.8 2.1 6.7 14.8 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein RCR PF12273.8 EEA26199.1 - 6.3e-16 59.1 27.8 1.8e-15 57.6 27.8 1.7 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red LysE PF01810.18 EEA26199.1 - 0.0098 15.4 0.5 0.012 15.1 0.5 1.1 1 0 0 1 1 1 1 LysE type translocator SARAF PF06682.12 EEA26199.1 - 0.03 14.0 1.0 0.035 13.7 1.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2157 PF09925.9 EEA26199.1 - 0.031 14.1 0.0 0.032 14.0 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Arf PF00025.21 EEA26200.1 - 1.2e-42 145.4 0.0 1.4e-42 145.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EEA26200.1 - 1.8e-18 66.6 0.0 2.1e-18 66.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA26200.1 - 1e-14 54.8 0.0 1.4e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EEA26200.1 - 6.6e-08 32.6 0.0 1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EEA26200.1 - 2.6e-06 27.0 0.0 3.3e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EEA26200.1 - 5.4e-06 26.0 0.0 6e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EEA26200.1 - 0.00015 21.0 0.0 0.00065 19.0 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.23 EEA26200.1 - 0.0044 17.1 0.0 0.065 13.3 0.1 2.1 1 1 1 2 2 2 1 Dynamin family MMR_HSR1_Xtn PF16897.5 EEA26200.1 - 0.0049 16.9 0.0 0.008 16.2 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.6 EEA26200.1 - 0.029 14.7 0.0 0.14 12.4 0.0 2.0 2 1 0 3 3 3 0 AAA domain FeoB_N PF02421.18 EEA26200.1 - 0.035 13.6 0.2 0.15 11.6 0.0 2.0 2 1 0 2 2 2 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EEA26200.1 - 0.069 13.0 0.0 11 5.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase DUF1979 PF09322.10 EEA26200.1 - 0.39 10.6 1.3 9.8 6.2 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) Peptidase_A4 PF01828.17 EEA26201.1 - 2.3e-74 249.4 13.6 2.8e-74 249.1 13.6 1.1 1 0 0 1 1 1 1 Peptidase A4 family RNA_pol_Rpb2_6 PF00562.28 EEA26202.1 - 8e-115 384.0 0.0 1.1e-114 383.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EEA26202.1 - 3.1e-34 118.3 0.0 5.6e-34 117.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EEA26202.1 - 5.7e-28 96.9 0.0 1.4e-27 95.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 EEA26202.1 - 1.5e-25 89.0 0.0 3e-25 88.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EEA26202.1 - 5.4e-25 88.1 0.0 1.1e-24 87.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EEA26202.1 - 2.2e-14 53.6 0.0 2e-13 50.5 0.1 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 Proteasome PF00227.26 EEA26203.1 - 2.5e-42 144.5 0.2 1.3e-32 112.8 0.1 2.0 2 0 0 2 2 2 2 Proteasome subunit Pil1 PF13805.6 EEA26204.1 - 6.1e-96 321.0 5.5 7.6e-96 320.7 5.5 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 Seryl_tRNA_N PF02403.22 EEA26204.1 - 0.04 14.1 2.3 0.12 12.6 2.3 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 EEA26204.1 - 0.27 11.8 3.2 0.65 10.5 3.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Pil1 PF13805.6 EEA26205.1 - 3.9e-64 216.7 2.8 4.8e-64 216.4 2.8 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 Seryl_tRNA_N PF02403.22 EEA26205.1 - 0.066 13.4 2.7 0.083 13.1 1.6 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Pan3_PK PF18101.1 EEA26206.1 - 0.0024 17.9 0.5 0.0043 17.0 0.5 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain MFS_1 PF07690.16 EEA26207.1 - 5e-33 114.5 23.9 5e-33 114.5 23.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily CLN3 PF02487.17 EEA26207.1 - 0.09 11.8 1.6 4.5 6.2 0.6 2.2 2 0 0 2 2 2 0 CLN3 protein MFS_1_like PF12832.7 EEA26207.1 - 0.21 10.4 8.4 0.0081 15.1 1.7 2.0 2 0 0 2 2 2 0 MFS_1 like family LHC PF00556.20 EEA26207.1 - 1.6 9.0 5.8 5.1 7.4 1.5 3.4 3 0 0 3 3 3 0 Antenna complex alpha/beta subunit Acetyltransf_10 PF13673.7 EEA26208.1 - 8.5e-09 35.4 0.0 2.1e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA26208.1 - 1.5e-06 28.5 0.0 2.6e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA26208.1 - 5e-06 26.8 0.0 5.7e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA26208.1 - 0.00021 21.4 0.0 0.00053 20.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA26208.1 - 0.052 13.5 0.0 0.36 10.8 0.0 2.3 2 1 1 3 3 3 0 FR47-like protein Acetyltransf_4 PF13420.7 EEA26208.1 - 0.11 12.6 0.0 0.37 10.9 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain SWI-SNF_Ssr4 PF08549.10 EEA26209.1 - 1.5e-249 830.5 17.0 1.2e-233 777.9 1.3 2.1 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1750) Uds1 PF15456.6 EEA26209.1 - 0.12 12.6 0.4 0.29 11.3 0.4 1.6 1 1 1 2 2 2 0 Up-regulated During Septation Methyltransf_23 PF13489.6 EEA26210.1 - 1.5e-19 70.4 0.0 2.1e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA26210.1 - 9.1e-10 39.1 0.0 3.4e-09 37.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA26210.1 - 7.9e-09 35.5 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EEA26210.1 - 4.6e-06 27.3 0.0 7.6e-05 23.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA26210.1 - 2.7e-05 24.7 0.0 5.2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EEA26210.1 - 0.0034 16.9 0.0 0.011 15.2 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 EEA26210.1 - 0.008 15.5 0.0 0.056 12.8 0.0 2.2 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EEA26210.1 - 0.017 15.2 0.0 0.039 14.1 0.0 1.6 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EEA26212.1 - 1.8e-20 73.2 0.0 2.8e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation PF08100.11 EEA26212.1 - 0.0006 19.8 0.4 0.0012 18.8 0.4 1.5 1 0 0 1 1 1 1 Dimerisation domain Ppx-GppA PF02541.16 EEA26214.1 - 8.9e-48 163.2 0.0 1.2e-47 162.7 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family TPR_14 PF13428.6 EEA26214.1 - 0.2 12.6 0.4 0.62 11.0 0.4 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat GDA1_CD39 PF01150.17 EEA26214.1 - 0.2 10.3 0.0 0.5 9.0 0.1 1.5 2 0 0 2 2 2 0 GDA1/CD39 (nucleoside phosphatase) family Thi4 PF01946.17 EEA26215.1 - 2.4e-112 373.9 0.0 2.9e-112 373.6 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EEA26215.1 - 8.1e-07 28.9 1.6 2.9e-06 27.1 1.4 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA26215.1 - 3.4e-05 24.0 0.4 0.00012 22.2 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA26215.1 - 0.00061 18.9 0.4 0.0015 17.7 0.4 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EEA26215.1 - 0.002 17.4 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA26215.1 - 0.0031 17.5 0.9 0.0074 16.3 0.1 2.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EEA26215.1 - 0.01 14.9 0.9 0.31 10.1 0.5 2.2 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EEA26215.1 - 0.075 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA26215.1 - 0.08 12.2 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EEA26215.1 - 0.095 11.4 0.4 0.17 10.5 0.4 1.4 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EEA26215.1 - 0.2 10.5 0.2 0.29 9.9 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EEA26216.1 - 2.4e-112 373.9 0.0 2.9e-112 373.6 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EEA26216.1 - 8.1e-07 28.9 1.6 2.9e-06 27.1 1.4 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA26216.1 - 3.4e-05 24.0 0.4 0.00012 22.2 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA26216.1 - 0.00061 18.9 0.4 0.0015 17.7 0.4 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EEA26216.1 - 0.002 17.4 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA26216.1 - 0.0031 17.5 0.9 0.0074 16.3 0.1 2.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EEA26216.1 - 0.01 14.9 0.9 0.31 10.1 0.5 2.2 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EEA26216.1 - 0.075 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA26216.1 - 0.08 12.2 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EEA26216.1 - 0.095 11.4 0.4 0.17 10.5 0.4 1.4 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EEA26216.1 - 0.2 10.5 0.2 0.29 9.9 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Exo_endo_phos PF03372.23 EEA26217.1 - 5.2e-12 45.8 0.0 8.1e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 EEA26218.1 - 2.5e-53 176.9 15.9 5.6e-10 39.7 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26218.1 - 7.1e-17 61.5 0.0 0.0025 18.1 0.0 5.8 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA26218.1 - 2.8e-11 42.8 3.6 0.087 11.5 0.1 5.6 1 1 4 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 EEA26218.1 - 3.4e-05 23.3 0.0 0.006 16.0 0.0 2.3 2 0 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 EEA26218.1 - 3.7e-05 22.9 0.5 5.8 5.8 0.0 4.8 1 1 4 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 EEA26218.1 - 0.00088 18.4 0.0 0.053 12.6 0.0 3.2 2 1 2 4 4 4 1 VID27 C-terminal WD40-like domain Frtz PF11768.8 EEA26218.1 - 0.017 13.5 0.0 0.051 11.9 0.0 1.7 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 EEA26218.1 - 0.085 12.2 0.5 14 4.9 0.0 3.2 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Cation_efflux PF01545.21 EEA26220.1 - 1.8e-15 57.2 5.9 2.4e-15 56.8 5.9 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EEA26220.1 - 2.3e-07 30.8 0.2 2.3e-07 30.8 0.2 2.0 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter STE2 PF02116.15 EEA26220.1 - 0.02 14.2 1.9 0.034 13.5 1.9 1.4 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR LRR_3 PF07725.12 EEA26220.1 - 0.02 14.7 0.2 0.51 10.3 0.1 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat Glyco_hydro_cc PF11790.8 EEA26221.1 - 4e-57 193.5 1.4 5e-57 193.2 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core RED_N PF07808.13 EEA26223.1 - 1.5e-10 41.0 6.2 1.5e-10 41.0 6.2 2.5 2 0 0 2 2 2 1 RED-like protein N-terminal region baeRF_family3 PF18845.1 EEA26223.1 - 9 6.5 10.8 0.25 11.6 2.9 2.4 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 zf-UBR PF02207.20 EEA26224.1 - 3.2e-17 62.4 17.6 3.2e-17 62.4 17.6 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EEA26224.1 - 0.018 14.8 0.0 0.049 13.4 0.0 1.8 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS SDA1 PF05285.12 EEA26224.1 - 0.22 10.9 6.7 0.44 9.9 6.7 1.4 1 0 0 1 1 1 0 SDA1 DUF2722 PF10846.8 EEA26224.1 - 1.7 7.5 8.9 0.11 11.4 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF2457 PF10446.9 EEA26224.1 - 5.8 5.9 13.3 16 4.5 13.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) UCR_UQCRX_QCR9 PF05365.12 EEA26225.1 - 3.1e-29 100.7 1.6 3.6e-29 100.5 1.6 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Mago-bind PF09282.10 EEA26226.1 - 1.4e-13 50.4 2.4 1.4e-13 50.4 2.4 2.0 2 0 0 2 2 2 1 Mago binding Nucleo_P87 PF07267.11 EEA26226.1 - 0.35 9.7 6.7 0.34 9.7 6.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Rtf2 PF04641.12 EEA26226.1 - 0.69 9.2 14.1 0.9 8.8 14.1 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger MDM10 PF12519.8 EEA26226.1 - 2.1 7.1 6.1 2.7 6.8 6.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 RR_TM4-6 PF06459.12 EEA26226.1 - 5.5 6.7 12.3 6.6 6.5 12.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 XRN_M PF17846.1 EEA26226.1 - 5.9 5.7 7.9 7.9 5.3 7.9 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Amino_oxidase PF01593.24 EEA26227.1 - 5.4e-30 105.1 0.0 7.4e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EEA26227.1 - 1.3e-14 54.2 0.0 3.5e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA26227.1 - 1e-06 28.6 0.0 5.9e-06 26.1 0.0 2.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA26227.1 - 0.00013 21.3 0.0 0.034 13.4 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA26227.1 - 0.0011 18.9 0.1 0.0095 15.9 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EEA26227.1 - 0.003 18.1 0.0 3.8 8.1 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA26227.1 - 0.0066 15.2 0.0 0.29 9.8 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein K_oxygenase PF13434.6 EEA26227.1 - 0.0069 15.6 0.0 0.1 11.7 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 EEA26227.1 - 0.0088 15.2 0.0 0.042 12.9 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain MCRA PF06100.11 EEA26227.1 - 0.019 13.8 0.0 0.029 13.2 0.0 1.2 1 0 0 1 1 1 0 MCRA family Thi4 PF01946.17 EEA26227.1 - 0.04 13.1 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EEA26227.1 - 0.1 11.6 0.4 0.58 9.2 0.0 2.2 3 0 0 3 3 3 0 Glucose inhibited division protein A zf-CCCH_2 PF14608.6 EEA26228.1 - 1.6e-11 44.2 59.8 0.00029 21.2 13.8 5.4 5 0 0 5 5 5 4 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 EEA26228.1 - 0.01 16.1 0.1 0.022 15.1 0.1 1.5 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Med20 PF08612.11 EEA26228.1 - 0.04 13.3 0.0 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 TATA-binding related factor (TRF) of subunit 20 of Mediator complex p450 PF00067.22 EEA26229.1 - 3.4e-56 190.9 0.0 4.5e-56 190.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GCV_T PF01571.21 EEA26230.1 - 7.7e-05 22.2 0.0 0.00033 20.1 0.0 1.9 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain Big_4 PF07532.11 EEA26230.1 - 0.0027 17.4 0.2 0.0059 16.3 0.2 1.5 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 4) DCP2 PF05026.13 EEA26231.1 - 6.2e-31 106.6 1.2 1.2e-30 105.6 1.2 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EEA26231.1 - 9.1e-17 61.3 0.1 1.6e-16 60.5 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4112 PF13430.6 EEA26232.1 - 9.6e-36 122.2 0.2 1.2e-35 121.9 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF4810 PF16068.5 EEA26232.1 - 0.12 13.0 0.0 4.4 7.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) CTU2 PF10288.9 EEA26233.1 - 3e-09 37.1 4.1 4.5e-09 36.5 0.0 2.4 1 1 1 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 zf-ribbon_3 PF13248.6 EEA26233.1 - 0.045 13.2 3.4 0.21 11.1 1.6 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-UBR PF02207.20 EEA26233.1 - 0.66 10.2 3.5 10 6.4 0.5 2.3 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) DZR PF12773.7 EEA26233.1 - 2 8.5 6.8 0.61 10.2 0.7 2.4 2 0 0 2 2 2 0 Double zinc ribbon Lung_7-TM_R PF06814.13 EEA26234.1 - 3.3e-71 240.0 17.6 3.9e-71 239.7 17.6 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SurA_N_3 PF13624.6 EEA26234.1 - 9.3 6.0 6.4 4.5 7.0 0.1 2.9 2 1 1 3 3 3 0 SurA N-terminal domain GFO_IDH_MocA PF01408.22 EEA26236.1 - 9.4e-17 61.9 0.1 1.6e-16 61.2 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EEA26236.1 - 3.5e-05 23.8 0.0 8.6e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DDE_Tnp_1_7 PF13843.6 EEA26237.1 - 6.3e-58 196.8 0.3 1.2e-57 195.8 0.3 1.5 1 1 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA26237.1 - 7.5e-12 45.8 9.4 1.6e-11 44.8 9.4 1.6 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon DUF1308 PF07000.11 EEA26238.1 - 1.5e-11 44.5 0.1 3.4e-10 40.1 0.1 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1308) DUF5614 PF18474.1 EEA26238.1 - 0.12 11.7 0.1 6.3 6.0 0.0 3.2 4 0 0 4 4 4 0 Family of unknown function (DUF5614) DUF4407 PF14362.6 EEA26238.1 - 0.12 11.7 1.5 0.21 10.9 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 EEA26239.1 - 7.6e-17 61.4 1.6 5.3e-06 27.1 0.0 5.5 4 1 1 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26239.1 - 5.3e-08 33.1 0.0 0.00093 19.5 0.0 3.7 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EEA26239.1 - 0.00033 19.5 0.1 0.0035 16.2 0.1 2.1 1 1 0 2 2 2 1 Nup133 N terminal like WDCP PF15390.6 EEA26239.1 - 0.023 13.1 0.0 0.3 9.4 0.0 2.1 2 0 0 2 2 2 0 WD repeat and coiled-coil-containing protein family Cytochrom_D1 PF02239.16 EEA26239.1 - 0.035 12.6 0.0 7.8 4.9 0.0 2.8 2 2 0 2 2 2 0 Cytochrome D1 heme domain Frtz PF11768.8 EEA26239.1 - 0.13 10.5 0.1 0.65 8.3 0.0 1.8 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Mito_carr PF00153.27 EEA26240.1 - 1.9e-51 171.9 5.0 2.4e-18 65.8 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribonuc_red_sm PF00268.21 EEA26241.1 - 3.7e-122 407.1 0.7 4.5e-122 406.9 0.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain SNF2_N PF00176.23 EEA26242.1 - 1.3e-69 234.6 0.0 2e-69 234.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EEA26242.1 - 6.8e-24 83.6 0.0 1.9e-23 82.2 0.0 1.8 2 0 0 2 2 2 1 HIRAN domain Helicase_C PF00271.31 EEA26242.1 - 1.2e-15 57.8 0.0 2.9e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA26242.1 - 4.2e-05 23.6 0.0 0.0001 22.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PLU-1 PF08429.11 EEA26242.1 - 0.00016 21.0 1.8 0.00038 19.7 1.8 1.5 1 0 0 1 1 1 1 PLU-1-like protein zf-C3HC4_2 PF13923.6 EEA26242.1 - 0.00076 19.3 4.0 0.0016 18.2 4.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA26242.1 - 0.0013 18.7 8.1 0.0026 17.7 8.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EEA26242.1 - 0.0014 18.5 6.2 0.0024 17.7 6.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA26242.1 - 0.0029 17.4 7.3 0.0055 16.6 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA26242.1 - 0.0041 17.4 8.0 0.0097 16.2 8.0 1.7 1 0 0 1 1 1 1 Ring finger domain UBA_4 PF14555.6 EEA26242.1 - 0.0068 16.2 0.0 0.045 13.6 0.0 2.4 3 0 0 3 3 3 1 UBA-like domain zf-RING_5 PF14634.6 EEA26242.1 - 0.043 13.8 6.2 0.089 12.8 6.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EEA26242.1 - 0.23 11.7 7.3 0.48 10.6 7.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SQS_PSY PF00494.19 EEA26243.1 - 6.3e-50 170.1 0.0 9.9e-50 169.5 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase CorA PF01544.18 EEA26244.1 - 1.6e-25 90.1 9.0 2.9e-19 69.5 1.6 3.1 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein Brr6_like_C_C PF10104.9 EEA26244.1 - 0.082 12.7 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain DUF3645 PF12359.8 EEA26244.1 - 1.1 8.7 0.0 1.1 8.7 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3645) DNApol_Exo PF18136.1 EEA26245.1 - 1.5e-106 355.7 0.1 2.5e-106 355.0 0.1 1.3 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EEA26245.1 - 1.4e-56 192.2 0.0 2.6e-56 191.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 EEA26245.1 - 0.002 17.9 0.2 0.059 13.1 0.2 2.5 1 1 0 1 1 1 1 3'-5' exonuclease Bromodomain PF00439.25 EEA26245.1 - 0.14 12.2 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Bromodomain zf-C3HC4 PF00097.25 EEA26246.1 - 7.1e-09 35.4 7.1 1.2e-08 34.6 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA26246.1 - 8.7e-09 35.3 0.8 2.1e-08 34.0 0.3 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA26246.1 - 1.2e-08 34.6 4.6 1.2e-08 34.6 4.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA26246.1 - 9.4e-08 32.3 6.3 1.7e-07 31.4 6.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EEA26246.1 - 1.4e-07 31.2 8.7 3.6e-07 29.9 8.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA26246.1 - 1.6e-06 28.0 7.1 2.8e-06 27.2 7.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EEA26246.1 - 2.8e-05 24.2 3.6 0.00031 20.8 4.4 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EEA26246.1 - 6.6e-05 22.7 6.7 0.00058 19.7 6.7 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 SART-1 PF03343.13 EEA26246.1 - 0.016 13.8 0.1 0.016 13.8 0.1 1.1 1 0 0 1 1 1 0 SART-1 family zf-RING_11 PF17123.5 EEA26246.1 - 0.28 11.0 6.9 0.69 9.7 6.9 1.7 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 EEA26246.1 - 0.29 11.0 7.9 0.84 9.5 7.9 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EEA26246.1 - 0.67 10.2 4.5 1.7 8.9 4.5 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_10 PF16685.5 EEA26246.1 - 0.97 9.6 5.9 4.4 7.5 5.8 2.1 1 1 1 2 2 2 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EEA26246.1 - 1.2 9.5 8.4 3.8 7.9 8.4 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain UPF0052 PF01933.18 EEA26247.1 - 1e-60 205.5 0.0 1.3e-60 205.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 ThiJ_like PF17124.5 EEA26248.1 - 7.4e-56 188.9 0.0 9.1e-56 188.7 0.0 1.0 1 0 0 1 1 1 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 EEA26248.1 - 1.3e-08 34.8 0.0 2.7e-08 33.8 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EEA26248.1 - 0.002 17.8 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain ArabFuran-catal PF09206.11 EEA26249.1 - 2e-141 470.9 13.0 2.6e-141 470.5 13.0 1.1 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 EEA26249.1 - 4.9e-56 188.6 1.6 7.7e-56 188.0 1.6 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain IL33 PF15095.6 EEA26249.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Interleukin 33 AMP-binding PF00501.28 EEA26250.1 - 2.6e-42 144.9 0.0 3.4e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EEA26250.1 - 0.0091 15.9 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus PNP_phzG_C PF10590.9 EEA26251.1 - 7.8e-22 77.1 5.3 7.7e-21 73.9 2.2 2.6 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EEA26251.1 - 1.3e-06 28.5 0.0 2.5e-05 24.4 0.0 2.3 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Rav1p_C PF12234.8 EEA26251.1 - 0.0086 14.5 0.0 0.012 14.1 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal EamA PF00892.20 EEA26252.1 - 7.7e-05 22.9 14.9 0.0018 18.5 14.9 2.0 1 1 0 1 1 1 1 EamA-like transporter family TMEM234 PF10639.9 EEA26252.1 - 0.011 15.7 1.6 0.015 15.3 1.6 1.2 1 0 0 1 1 1 0 Putative transmembrane family 234 COQ7 PF03232.13 EEA26252.1 - 9.5 6.0 5.7 4.9 6.9 0.6 2.1 2 0 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 Voltage_CLC PF00654.20 EEA26253.1 - 2.8e-87 293.2 27.2 2.8e-87 293.2 27.2 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EEA26253.1 - 2.4e-11 43.9 0.0 5.4e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 CBS domain CBFD_NFYB_HMF PF00808.23 EEA26254.1 - 1.6e-16 60.4 0.7 2.3e-15 56.6 0.1 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA26254.1 - 0.0024 18.2 0.2 0.0024 18.2 0.2 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Rieske PF00355.26 EEA26255.1 - 2.7e-11 43.2 0.0 5.3e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EEA26255.1 - 7e-11 42.4 0.5 1.4e-10 41.5 0.5 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region PPR_2 PF13041.6 EEA26256.1 - 2.5e-42 142.8 7.9 2e-09 37.5 0.0 13.0 11 4 4 15 15 15 7 PPR repeat family PPR_3 PF13812.6 EEA26256.1 - 2.4e-28 98.0 0.0 0.0029 17.6 0.0 10.8 8 3 3 11 11 11 8 Pentatricopeptide repeat domain PPR PF01535.20 EEA26256.1 - 6e-22 76.3 30.8 0.00056 20.0 0.1 15.1 19 1 0 19 19 19 6 PPR repeat PPR_1 PF12854.7 EEA26256.1 - 8.3e-22 76.6 0.1 2.4e-06 27.2 0.0 10.7 11 0 0 11 11 11 3 PPR repeat PPR_long PF17177.4 EEA26256.1 - 8.7e-19 67.7 13.7 2.4e-08 33.6 0.0 6.3 4 1 1 5 5 5 3 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 EEA26256.1 - 1.2e-08 35.3 0.1 1.7e-06 28.4 0.0 3.9 4 0 0 4 4 4 1 Mitochondrial ribonuclease P subunit (RPM2) SelB-wing_2 PF09106.11 EEA26256.1 - 0.0077 16.4 0.0 0.34 11.1 0.0 4.0 5 0 0 5 5 4 1 Elongation factor SelB, winged helix RPN7 PF10602.9 EEA26256.1 - 0.015 15.0 0.2 3.6 7.3 0.0 3.4 3 0 0 3 3 3 0 26S proteasome subunit RPN7 Serglycin PF04360.12 EEA26256.1 - 0.023 14.6 0.4 0.06 13.3 0.4 1.7 1 0 0 1 1 1 0 Serglycin TPR_7 PF13176.6 EEA26256.1 - 0.063 13.3 1.7 23 5.3 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4205 PF13898.6 EEA26256.1 - 0.073 12.0 0.1 0.13 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) DUF507 PF04368.13 EEA26256.1 - 0.29 11.0 2.4 1.6 8.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF507) GHMP_kinases_N PF00288.26 EEA26257.1 - 1.3e-13 51.0 1.9 2.7e-13 49.9 1.9 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EEA26257.1 - 4e-11 43.1 0.1 2.1e-10 40.8 0.0 2.3 1 1 0 1 1 1 1 GHMP kinases C terminal Rad60-SLD_2 PF13881.6 EEA26258.1 - 9.7e-12 45.0 0.0 2.7e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EEA26258.1 - 0.00055 20.5 0.0 0.0016 19.0 0.0 1.7 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EEA26258.1 - 0.0031 17.2 0.3 0.0094 15.7 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family UMP1 PF05348.11 EEA26259.1 - 1.2e-37 128.7 0.0 1.5e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Ribosom_S12_S23 PF00164.25 EEA26260.1 - 1e-29 102.5 0.9 1.5e-29 101.9 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Glyco_transf_15 PF01793.16 EEA26261.1 - 3.1e-131 437.5 5.6 3.8e-131 437.2 5.6 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase EGF_3 PF12947.7 EEA26261.1 - 0.22 11.8 1.5 0.42 10.8 1.5 1.5 1 0 0 1 1 1 0 EGF domain PAT1 PF09770.9 EEA26262.1 - 0 1151.0 10.7 0 1147.0 10.7 1.9 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Erf4 PF10256.9 EEA26262.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family GDP_Man_Dehyd PF16363.5 EEA26263.1 - 3.7e-51 174.5 0.0 9.2e-51 173.2 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EEA26263.1 - 4.3e-47 160.6 0.0 5.8e-47 160.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA26263.1 - 3.5e-15 55.7 0.0 1e-14 54.3 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EEA26263.1 - 4.4e-12 45.7 0.0 1.3e-10 40.9 0.0 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA26263.1 - 5.5e-12 45.4 0.0 7.9e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EEA26263.1 - 3.6e-10 39.6 0.0 6.7e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA26263.1 - 3.6e-08 33.5 0.0 6.3e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA26263.1 - 1.6e-05 24.9 0.0 2.4e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short_C2 PF13561.6 EEA26263.1 - 2e-05 24.3 0.0 3.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_4 PF07993.12 EEA26263.1 - 0.00021 20.6 0.1 0.0055 15.9 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EEA26263.1 - 0.016 14.8 0.0 0.031 13.8 0.0 1.5 2 0 0 2 2 2 0 NmrA-like family UDPG_MGDP_dh_N PF03721.14 EEA26263.1 - 0.081 12.5 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF2759 PF10958.8 EEA26263.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) adh_short PF00106.25 EEA26264.1 - 1.5e-14 53.9 0.0 1.5e-11 44.1 0.0 2.4 1 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EEA26264.1 - 9.1e-08 32.2 0.0 3.1e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 EEA26264.1 - 2.6e-07 30.5 0.0 0.00012 21.7 0.0 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EEA26264.1 - 0.037 13.5 0.1 0.15 11.5 0.1 2.2 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA26264.1 - 0.17 11.0 0.0 0.17 11.0 0.0 2.3 3 0 0 3 3 3 0 Polysaccharide biosynthesis protein SUV3_C PF12513.8 EEA26265.1 - 1.6e-18 66.3 0.6 3.8e-18 65.2 0.6 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EEA26265.1 - 1.2e-10 41.7 0.0 2.8e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 EEA26265.1 - 0.0093 15.8 0.2 0.021 14.7 0.2 1.7 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 DUF4771 PF15995.5 EEA26265.1 - 0.079 13.2 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) Sec1 PF00995.23 EEA26266.1 - 2e-121 407.1 0.0 2.3e-121 406.9 0.0 1.0 1 0 0 1 1 1 1 Sec1 family G-patch PF01585.23 EEA26267.1 - 0.0041 17.0 0.1 0.0093 15.8 0.1 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EEA26267.1 - 0.012 15.7 0.1 0.031 14.4 0.1 1.7 1 0 0 1 1 1 0 G-patch domain HA2 PF04408.23 EEA26268.1 - 7.8e-25 87.3 0.1 7.8e-25 87.3 0.1 2.6 3 0 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA26268.1 - 1.6e-19 70.0 0.0 3.4e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA26268.1 - 1e-13 51.6 0.0 2.6e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EEA26268.1 - 1.7e-09 37.9 2.3 1e-08 35.4 0.9 2.4 2 0 0 2 2 2 1 S1 RNA binding domain DEAD PF00270.29 EEA26268.1 - 1.8e-06 27.8 0.1 3.9e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA26268.1 - 0.00022 21.5 0.0 0.00057 20.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EEA26268.1 - 0.0011 18.3 0.0 0.002 17.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EEA26268.1 - 0.0022 17.1 0.0 0.0051 15.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EEA26268.1 - 0.003 17.3 0.0 0.008 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA26268.1 - 0.016 15.5 0.0 0.038 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 EEA26268.1 - 0.04 13.9 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain SRP54 PF00448.22 EEA26268.1 - 0.056 13.1 0.1 0.14 11.8 0.1 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EEA26268.1 - 0.086 13.2 0.2 0.29 11.5 0.0 1.9 2 0 0 2 2 1 0 AAA ATPase domain ABC_tran PF00005.27 EEA26268.1 - 0.11 13.0 0.8 3.2 8.3 0.2 3.0 2 1 0 3 3 3 0 ABC transporter Microtub_bd PF16796.5 EEA26268.1 - 0.15 12.0 0.2 3 7.8 0.0 2.7 3 0 0 3 3 3 0 Microtubule binding ATPase PF06745.13 EEA26268.1 - 0.15 11.3 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 EEA26268.1 - 0.16 11.4 0.1 0.51 9.7 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein DUF5427 PF10310.9 EEA26268.1 - 6.2 5.7 10.5 1.3 7.9 5.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Npa1 PF11707.8 EEA26269.1 - 1.4e-97 327.1 0.6 6e-96 321.8 0.2 2.6 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EEA26269.1 - 2e-58 197.3 1.2 1.5e-57 194.5 0.1 3.0 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Creb_binding PF09030.10 EEA26269.1 - 0.0099 16.6 0.0 0.045 14.4 0.0 2.1 1 0 0 1 1 1 1 Creb binding Fungal_trans PF04082.18 EEA26271.1 - 2.9e-22 79.0 0.0 5e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26271.1 - 0.00089 19.3 8.3 0.0016 18.5 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_71 PF03659.14 EEA26272.1 - 1.1e-122 409.5 6.1 1.2e-122 409.3 6.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Zn_clus PF00172.18 EEA26273.1 - 6.8e-09 35.7 9.5 1.3e-08 34.8 9.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA26273.1 - 2.1e-07 30.1 0.7 2.8e-07 29.7 0.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Abhydrolase_3 PF07859.13 EEA26274.1 - 1.3e-31 110.1 0.1 2e-30 106.2 0.1 2.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EEA26274.1 - 0.0027 17.9 0.0 0.0061 16.7 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain COesterase PF00135.28 EEA26274.1 - 0.025 13.5 0.0 0.036 12.9 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family DUF2974 PF11187.8 EEA26274.1 - 0.064 12.8 0.0 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Chlorophyllase PF07224.11 EEA26274.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase AbiEii PF08843.11 EEA26275.1 - 9.2e-06 25.8 0.0 0.0062 16.5 0.0 2.0 1 1 1 2 2 2 2 Nucleotidyl transferase AbiEii toxin, Type IV TA system Pirin PF02678.16 EEA26277.1 - 4.6e-26 90.9 0.5 1.1e-25 89.8 0.5 1.6 1 1 0 1 1 1 1 Pirin Cupin_2 PF07883.11 EEA26277.1 - 8.4e-06 25.4 2.9 0.0002 21.0 0.4 2.9 2 1 0 2 2 2 2 Cupin domain MFS_1 PF07690.16 EEA26278.1 - 2.2e-27 95.9 40.0 3.9e-27 95.1 40.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EEA26278.1 - 1.1e-06 27.9 2.6 2e-06 27.0 2.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain COesterase PF00135.28 EEA26279.1 - 9.1e-82 275.5 0.6 1.2e-81 275.2 0.6 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA26279.1 - 1.4e-09 38.1 0.2 1.1e-08 35.2 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pro_dh PF01619.18 EEA26280.1 - 8.7e-61 206.0 0.5 1.1e-60 205.7 0.5 1.1 1 0 0 1 1 1 1 Proline dehydrogenase DUF4524 PF15025.6 EEA26280.1 - 0.081 12.7 0.7 0.16 11.7 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4524) PI-PLC-X PF00388.19 EEA26281.1 - 1.6e-06 27.8 0.0 2.6e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain 4HBT_3 PF13622.6 EEA26282.1 - 2.6e-81 273.6 0.1 4.4e-81 272.8 0.1 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EEA26282.1 - 5e-23 81.4 0.0 1.1e-10 41.5 0.0 4.4 3 1 0 3 3 3 3 Acyl-CoA thioesterase GFA PF04828.14 EEA26282.1 - 3.2e-20 72.3 1.0 6.6e-20 71.2 1.0 1.6 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme His_Phos_2 PF00328.22 EEA26282.1 - 0.037 13.4 0.0 0.29 10.4 0.0 2.0 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) Thaumatin PF00314.17 EEA26283.1 - 1.3e-67 227.6 0.9 2.5e-67 226.7 0.9 1.4 1 1 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 EEA26283.1 - 0.015 14.6 0.4 3.4 6.9 0.0 2.2 2 0 0 2 2 2 0 Beta-1,3-glucanase Pico_P2A PF00947.19 EEA26283.1 - 0.073 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Picornavirus core protein 2A Fungal_trans PF04082.18 EEA26284.1 - 2e-27 95.9 0.2 4e-27 94.9 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26284.1 - 7.3e-06 26.0 9.7 1.4e-05 25.1 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA26285.1 - 1.6e-12 47.0 0.4 3.1e-12 46.1 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Corona_S2 PF01601.16 EEA26285.1 - 0.1 11.1 0.0 0.14 10.6 0.0 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein COesterase PF00135.28 EEA26286.1 - 3.9e-64 217.4 0.0 5.1e-64 217.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA26286.1 - 3.8e-07 30.2 0.8 0.0031 17.4 0.3 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Sugar_tr PF00083.24 EEA26287.1 - 3.7e-89 299.6 15.0 2.3e-64 218.0 1.6 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EEA26287.1 - 8.2e-13 48.0 25.5 9.8e-13 47.7 15.4 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EEA26288.1 - 1.1e-24 86.9 0.1 1.7e-24 86.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26288.1 - 4e-05 23.6 15.6 0.00012 22.1 15.6 1.8 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Prefoldin_2 PF01920.20 EEA26289.1 - 4.3e-23 81.3 3.0 5.2e-23 81.0 3.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit FTA4 PF13093.6 EEA26289.1 - 0.071 13.0 3.5 0.088 12.7 3.5 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF5065 PF16723.5 EEA26289.1 - 0.073 13.1 0.0 0.082 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5065) DUF5082 PF16888.5 EEA26289.1 - 0.09 13.1 3.1 0.16 12.3 3.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) eIF-4B PF06273.11 EEA26289.1 - 0.18 10.8 4.5 0.2 10.7 4.5 1.0 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B APG6_N PF17675.1 EEA26289.1 - 1.1 9.8 12.2 8.4 6.9 0.1 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region ATG27 PF09451.10 EEA26290.1 - 2.3e-87 293.2 0.0 2.8e-87 292.9 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EEA26290.1 - 0.0017 18.5 0.1 0.24 11.5 0.1 2.7 3 0 0 3 3 3 2 Cation-independent mannose-6-phosphate receptor repeat Sulfotransfer_3 PF13469.6 EEA26291.1 - 0.02 15.3 0.0 2.1 8.7 0.0 3.1 1 1 0 1 1 1 0 Sulfotransferase family AAA_2 PF07724.14 EEA26292.1 - 1.6e-46 158.5 0.0 4.1e-45 154.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EEA26292.1 - 3.5e-33 113.6 1.1 3.5e-33 113.6 1.1 4.2 4 0 0 4 4 4 1 AAA lid domain AAA PF00004.29 EEA26292.1 - 9.3e-27 94.0 0.0 3.5e-14 53.4 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EEA26292.1 - 1.8e-24 85.6 2.1 4e-24 84.5 0.3 2.6 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EEA26292.1 - 3.5e-15 56.2 0.0 4.4e-09 36.5 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA26292.1 - 5.6e-14 52.6 0.1 5.5e-05 23.5 0.0 4.7 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EEA26292.1 - 6e-12 46.3 10.0 7.5e-07 29.7 0.1 5.1 6 1 0 6 6 3 2 AAA ATPase domain Sigma54_activat PF00158.26 EEA26292.1 - 1.1e-08 35.0 0.0 2.7e-05 23.9 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 EEA26292.1 - 3.1e-06 27.3 0.0 0.086 12.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EEA26292.1 - 3.6e-06 27.5 2.2 0.043 14.4 0.0 4.1 4 1 1 5 5 3 2 AAA domain AAA_7 PF12775.7 EEA26292.1 - 4.6e-06 26.3 0.0 0.015 14.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 EEA26292.1 - 5.4e-06 26.2 0.0 0.065 13.0 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_33 PF13671.6 EEA26292.1 - 1.7e-05 25.0 0.0 0.27 11.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EEA26292.1 - 2.1e-05 24.0 0.0 0.18 11.2 0.0 3.4 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 EEA26292.1 - 2.6e-05 23.7 0.7 0.24 10.8 0.0 4.5 4 2 1 5 5 4 1 Bacterial TniB protein ATPase_2 PF01637.18 EEA26292.1 - 4.1e-05 23.6 3.8 0.084 12.8 0.2 4.2 4 1 0 4 4 3 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EEA26292.1 - 5.8e-05 23.4 1.5 0.62 10.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 EEA26292.1 - 7.3e-05 23.1 0.0 0.56 10.6 0.0 2.5 2 0 0 2 2 2 2 RNA helicase RuvB_N PF05496.12 EEA26292.1 - 0.00021 21.1 1.3 4.2 7.1 0.7 4.5 3 1 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EEA26292.1 - 0.00021 21.0 0.0 1.3 8.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EEA26292.1 - 0.00026 21.0 0.0 0.57 10.1 0.0 3.0 2 0 0 2 2 2 2 RsgA GTPase TsaE PF02367.17 EEA26292.1 - 0.00029 20.8 0.0 0.41 10.6 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Clp_N PF02861.20 EEA26292.1 - 0.00029 20.9 0.8 0.37 11.0 0.0 3.8 3 0 0 3 3 3 1 Clp amino terminal domain, pathogenicity island component AAA_3 PF07726.11 EEA26292.1 - 0.00034 20.5 0.0 1.1 9.1 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 EEA26292.1 - 0.0007 19.7 0.0 0.0073 16.4 0.0 2.4 3 0 0 3 3 3 1 Torsin ABC_tran PF00005.27 EEA26292.1 - 0.00073 20.1 1.8 0.55 10.7 0.0 3.4 4 0 0 4 4 2 1 ABC transporter AAA_24 PF13479.6 EEA26292.1 - 0.00086 19.1 0.0 0.82 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EEA26292.1 - 0.00091 18.4 0.0 0.027 13.5 0.0 2.8 2 1 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.6 EEA26292.1 - 0.00099 19.5 0.1 0.4 11.0 0.1 3.3 2 1 1 3 3 2 1 AAA domain AAA_29 PF13555.6 EEA26292.1 - 0.0032 17.2 0.0 3.5 7.4 0.0 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EEA26292.1 - 0.0052 16.7 0.0 0.48 10.3 0.0 2.9 2 0 0 2 2 2 1 NACHT domain ResIII PF04851.15 EEA26292.1 - 0.0064 16.5 0.0 1.2 9.1 0.0 3.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_23 PF13476.6 EEA26292.1 - 0.0067 16.9 12.0 0.37 11.2 0.0 4.0 5 1 0 5 5 3 1 AAA domain Roc PF08477.13 EEA26292.1 - 0.011 15.9 0.0 3.4 7.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 EEA26292.1 - 0.011 15.3 2.8 0.53 9.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 EEA26292.1 - 0.015 15.3 0.0 0.27 11.1 0.0 2.6 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 EEA26292.1 - 0.016 14.5 0.0 1.4 8.1 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.15 EEA26292.1 - 0.016 15.1 0.0 5.9 6.8 0.0 2.7 2 0 0 2 2 2 0 Rad17 P-loop domain SRP54 PF00448.22 EEA26292.1 - 0.043 13.5 0.0 7.1 6.2 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_21 PF13304.6 EEA26292.1 - 0.14 12.0 0.6 21 4.8 0.0 3.7 4 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Macoilin PF09726.9 EEA26292.1 - 0.29 9.6 5.0 0.52 8.8 5.0 1.3 1 0 0 1 1 1 0 Macoilin family BPL_N PF09825.9 EEA26292.1 - 0.37 9.8 1.0 1 8.4 1.0 1.7 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal V_ATPase_I PF01496.19 EEA26292.1 - 0.5 8.2 2.2 0.75 7.6 2.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YlqD PF11068.8 EEA26292.1 - 0.89 9.9 8.6 0.17 12.2 3.7 2.5 2 0 0 2 2 1 0 YlqD protein Spc7 PF08317.11 EEA26292.1 - 0.94 8.3 10.1 2.4 7.0 10.1 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 EEA26292.1 - 5.7 7.2 14.1 2.3 8.5 9.7 2.5 3 0 0 3 3 2 0 TATA element modulatory factor 1 TATA binding Polysacc_deac_1 PF01522.21 EEA26293.1 - 2.2e-18 66.3 0.0 4.8e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EEA26293.1 - 2.6e-07 30.5 0.0 5.9e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) adh_short PF00106.25 EEA26293.1 - 5.5e-07 29.2 0.0 6.5e-06 25.7 0.0 2.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA26293.1 - 7.9e-06 25.6 0.0 2e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EEA26293.1 - 0.0026 17.2 0.0 0.0049 16.3 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_hydro_75 PF07335.11 EEA26294.1 - 4.3e-59 199.4 0.1 8.8e-59 198.4 0.1 1.5 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 Zn_clus PF00172.18 EEA26294.1 - 1.7e-11 44.1 11.3 3.5e-11 43.0 11.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA26294.1 - 3.4e-09 36.1 0.5 5.9e-09 35.3 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EEA26295.1 - 6.3e-35 120.7 28.2 6.3e-35 120.7 28.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA26295.1 - 1.4e-08 34.1 13.2 1.6e-07 30.6 13.2 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter Neurensin PF14927.6 EEA26295.1 - 0.0017 18.1 1.3 0.4 10.4 0.5 2.8 2 0 0 2 2 2 2 Neurensin UNC-93 PF05978.16 EEA26296.1 - 3e-11 43.3 3.9 3e-11 43.3 3.9 2.3 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EEA26296.1 - 5.1e-10 38.8 43.4 1.2e-09 37.6 43.4 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily LapA_dom PF06305.11 EEA26296.1 - 0.08 12.8 0.1 0.08 12.8 0.1 3.7 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain BcrAD_BadFG PF01869.20 EEA26297.1 - 2.7e-16 59.9 0.5 5.4e-16 58.9 0.5 1.5 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family SIS_2 PF13580.6 EEA26297.1 - 7.4e-05 22.8 0.0 0.00099 19.1 0.0 2.8 1 1 0 1 1 1 1 SIS domain SIS PF01380.22 EEA26297.1 - 0.0094 15.8 1.4 0.027 14.3 0.0 2.4 3 0 0 3 3 3 1 SIS domain DUF1343 PF07075.11 EEA26298.1 - 3e-118 395.2 0.0 3.9e-118 394.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1343) DUF1343 PF07075.11 EEA26299.1 - 2e-118 395.8 0.0 2.6e-118 395.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1343) Beta-lactamase PF00144.24 EEA26300.1 - 2.3e-53 181.6 0.9 3e-53 181.2 0.9 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EEA26300.1 - 0.0013 18.2 0.2 0.011 15.2 0.1 2.3 2 1 1 3 3 3 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 EEA26300.1 - 0.072 12.7 0.6 0.29 10.7 0.0 2.2 3 0 0 3 3 3 0 Beta-lactamase enzyme family SnoaL_2 PF12680.7 EEA26301.1 - 9e-06 26.3 0.1 9.8e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain EMC3_TMCO1 PF01956.16 EEA26302.1 - 0.58 9.9 5.2 12 5.6 0.1 2.5 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like AA_permease_2 PF13520.6 EEA26303.1 - 5.9e-49 167.0 49.6 7.5e-49 166.7 49.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA26303.1 - 7.7e-24 84.1 42.1 1e-23 83.7 42.1 1.1 1 0 0 1 1 1 1 Amino acid permease MerE PF05052.12 EEA26303.1 - 0.0028 17.5 0.6 0.018 14.9 0.6 2.4 1 0 0 1 1 1 1 MerE protein SID-1_RNA_chan PF13965.6 EEA26303.1 - 3.7 5.9 12.8 0.032 12.7 2.5 2.4 2 1 1 3 3 3 0 dsRNA-gated channel SID-1 Aldo_ket_red PF00248.21 EEA26304.1 - 1.8e-66 224.4 0.0 2e-66 224.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Fungal_trans_2 PF11951.8 EEA26305.1 - 1.3e-06 27.5 2.1 1.9e-06 27.0 2.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26305.1 - 2.8e-06 27.3 8.8 8e-06 25.9 8.8 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SNF2_N PF00176.23 EEA26306.1 - 9.8e-58 195.5 0.0 1.5e-57 194.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA26306.1 - 1.4e-14 54.3 0.0 3.2e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA26306.1 - 3.9e-10 40.0 1.0 8.4e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA26306.1 - 3.9e-05 23.5 0.0 7.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EEA26306.1 - 0.006 16.3 1.0 0.0069 16.1 0.0 1.6 2 0 0 2 2 2 1 SWI2/SNF2 ATPase SUKH-4 PF14435.6 EEA26306.1 - 0.18 11.9 0.2 0.42 10.6 0.2 1.5 1 0 0 1 1 1 0 SUKH-4 immunity protein EBP PF05241.12 EEA26308.1 - 1.1e-57 194.3 10.8 1.4e-57 194.0 10.8 1.0 1 0 0 1 1 1 1 Emopamil binding protein DUF2347 PF09804.9 EEA26309.1 - 4.9e-105 351.2 0.0 6.4e-105 350.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EEA26309.1 - 6.7e-58 196.2 0.3 2.3e-57 194.5 0.3 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4484) Avl9 PF09794.9 EEA26309.1 - 0.00043 19.1 0.0 0.019 13.7 0.0 2.4 2 1 0 2 2 2 2 Transport protein Avl9 SPA PF08616.10 EEA26309.1 - 0.0021 18.0 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Tubulin_3 PF14881.6 EEA26311.1 - 1.4e-83 279.0 0.1 1.1e-82 276.1 0.0 2.0 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.9 EEA26311.1 - 1e-43 148.4 0.0 3.1e-43 146.8 0.0 1.9 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 EEA26311.1 - 0.00013 22.2 0.0 0.71 10.0 0.0 2.5 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain HSP70 PF00012.20 EEA26312.1 - 3.6e-63 213.7 3.3 7.7e-62 209.3 0.5 2.6 3 0 0 3 3 3 2 Hsp70 protein DUF4296 PF14129.6 EEA26312.1 - 0.048 14.3 0.1 0.2 12.3 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) MFS_1 PF07690.16 EEA26313.1 - 1.1e-13 50.9 9.1 1.2e-13 50.7 9.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily RNR_inhib PF08591.10 EEA26315.1 - 2.8e-26 92.9 0.4 2.8e-26 92.9 0.4 2.5 3 0 0 3 3 3 1 Ribonucleotide reductase inhibitor adh_short PF00106.25 EEA26316.1 - 8.9e-22 77.5 0.5 7.6e-21 74.5 0.3 2.1 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA26316.1 - 4.9e-11 42.9 0.6 1.9e-10 41.0 0.2 2.2 2 1 1 3 3 3 1 KR domain adh_short_C2 PF13561.6 EEA26316.1 - 1.5e-09 37.8 0.8 5.8e-09 35.9 0.1 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EEA26316.1 - 0.02 14.3 0.1 0.18 11.2 0.1 2.1 1 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Fungal_trans_2 PF11951.8 EEA26317.1 - 9.3e-08 31.3 0.7 2.2e-07 30.1 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain SDA1 PF05285.12 EEA26318.1 - 7.6e-89 298.5 59.9 9.9e-89 298.2 48.8 3.1 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EEA26318.1 - 1.1e-23 83.3 0.0 2.9e-23 81.9 0.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain Chordopox_A30L PF06015.12 EEA26318.1 - 3.5 7.5 8.3 6.1 6.7 6.0 2.7 2 0 0 2 2 2 0 Chordopoxvirus A30L protein Ribosomal_S7 PF00177.21 EEA26319.1 - 4.7e-35 120.4 3.1 6e-35 120.1 3.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e AMP-binding PF00501.28 EEA26320.1 - 1.1e-67 228.4 0.7 9e-37 126.7 0.0 3.5 2 2 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 EEA26320.1 - 2.5e-09 37.9 0.0 2.1e-08 34.9 0.0 2.3 2 0 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.12 EEA26320.1 - 0.031 14.3 0.5 0.063 13.3 0.5 1.5 1 0 0 1 1 1 0 Gas vesicle protein G HMGL-like PF00682.19 EEA26322.1 - 4.5e-81 272.3 0.0 6.7e-81 271.7 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EEA26322.1 - 5.5e-21 74.9 0.0 1.3e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain HMGL-like PF00682.19 EEA26323.1 - 7e-70 235.6 0.0 1.1e-69 235.0 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EEA26323.1 - 4.4e-21 75.2 0.0 1.1e-20 73.9 0.0 1.7 1 1 0 1 1 1 1 LeuA allosteric (dimerisation) domain DEAD PF00270.29 EEA26324.1 - 1.3e-48 165.1 0.0 3.3e-48 163.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA26324.1 - 2.9e-31 108.1 1.3 2.3e-29 102.0 0.2 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EEA26324.1 - 0.00027 19.8 1.8 0.002 17.0 0.1 2.9 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 zf-C2H2 PF00096.26 EEA26325.1 - 7.3e-05 23.0 10.8 0.086 13.3 1.5 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EEA26325.1 - 0.00012 22.3 1.0 0.055 13.6 0.0 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EEA26325.1 - 0.00063 20.4 12.4 0.037 14.9 1.1 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA26325.1 - 0.024 15.1 0.5 0.024 15.1 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EEA26325.1 - 0.52 10.7 5.9 1.4 9.3 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF4719 PF15843.5 EEA26325.1 - 1.7 8.7 8.5 2.2 8.3 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4719) zf-C2H2 PF00096.26 EEA26326.1 - 7.3e-05 23.0 10.8 0.086 13.3 1.5 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EEA26326.1 - 0.00012 22.3 1.0 0.055 13.6 0.0 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EEA26326.1 - 0.00063 20.4 12.4 0.037 14.9 1.1 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA26326.1 - 0.024 15.1 0.5 0.024 15.1 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EEA26326.1 - 0.52 10.7 5.9 1.4 9.3 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF4719 PF15843.5 EEA26326.1 - 1.7 8.7 8.5 2.2 8.3 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4719) Dus PF01207.17 EEA26327.1 - 1.5e-42 145.8 0.0 9.9e-30 103.7 0.0 3.0 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf_CCCH_4 PF18345.1 EEA26327.1 - 1e-06 28.6 5.7 0.014 15.4 0.3 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EEA26327.1 - 1.1e-06 28.3 3.0 0.00022 21.0 0.3 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 EEA26327.1 - 5.4e-06 26.2 3.1 0.021 14.7 0.4 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EEA26327.1 - 0.13 13.0 11.2 0.34 11.6 0.3 2.9 2 1 1 3 3 3 0 Torus domain Mis14 PF08641.12 EEA26327.1 - 0.17 12.2 4.7 0.19 12.0 1.2 2.3 2 0 0 2 2 2 0 Kinetochore protein Mis14 like zf-CCCH_2 PF14608.6 EEA26327.1 - 0.39 11.3 3.4 3.1 8.4 0.5 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger MMM1 PF10296.9 EEA26328.1 - 2.2e-06 27.0 0.0 6.1e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 IER PF05760.12 EEA26328.1 - 0.2 11.9 2.6 3.1 8.0 0.1 2.3 2 0 0 2 2 2 0 Immediate early response protein (IER) Sigma70_ner PF04546.13 EEA26328.1 - 0.37 10.6 3.4 3.4 7.5 1.7 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region Bap31 PF05529.12 EEA26329.1 - 1.7e-46 157.5 9.3 2.2e-46 157.1 9.3 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EEA26329.1 - 2.6e-15 56.1 5.2 4.7e-15 55.3 5.2 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 EEA26329.1 - 0.0097 15.7 2.3 0.09 12.6 0.3 3.1 3 0 0 3 3 3 1 Septum formation initiator Csm1_N PF18504.1 EEA26329.1 - 0.062 13.6 0.2 0.12 12.8 0.2 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain Bap31 PF05529.12 EEA26330.1 - 1.3e-46 157.8 9.3 1.8e-46 157.4 9.3 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EEA26330.1 - 2.6e-15 56.1 5.2 4.8e-15 55.3 5.2 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 EEA26330.1 - 0.011 15.5 2.5 0.091 12.5 0.3 3.1 3 0 0 3 3 3 0 Septum formation initiator Csm1_N PF18504.1 EEA26330.1 - 0.062 13.6 0.2 0.12 12.8 0.2 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain Pkinase PF00069.25 EEA26333.1 - 7.6e-64 215.6 0.0 1.3e-63 214.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26333.1 - 5.2e-35 121.0 0.0 3.5e-29 101.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA26333.1 - 4.9e-07 29.4 0.0 0.0012 18.2 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 EEA26333.1 - 5.5e-05 23.2 0.0 0.00048 20.1 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EEA26333.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EEA26333.1 - 0.078 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EEA26333.1 - 0.094 11.6 0.0 0.2 10.5 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Senescence PF06911.12 EEA26335.1 - 2e-53 181.4 3.9 3.6e-53 180.6 3.9 1.4 1 0 0 1 1 1 1 Senescence-associated protein Acyl-CoA_dh_1 PF00441.24 EEA26336.1 - 1.1e-39 136.1 8.4 1.8e-39 135.3 8.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA26336.1 - 9.7e-30 103.5 1.6 1.4e-29 103.0 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA26336.1 - 1.8e-24 85.8 0.0 4.1e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA26336.1 - 1e-16 61.4 4.3 1.7e-16 60.7 4.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EEA26336.1 - 0.027 14.1 0.0 0.064 12.9 0.0 1.6 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_1 PF00441.24 EEA26337.1 - 1.1e-39 136.1 8.4 1.8e-39 135.3 8.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA26337.1 - 9.7e-30 103.5 1.6 1.4e-29 103.0 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA26337.1 - 1.8e-24 85.8 0.0 4.1e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA26337.1 - 1e-16 61.4 4.3 1.7e-16 60.7 4.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EEA26337.1 - 0.027 14.1 0.0 0.064 12.9 0.0 1.6 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal bZIP_1 PF00170.21 EEA26338.1 - 6.2e-05 23.0 7.7 0.00014 21.9 7.7 1.6 1 1 0 1 1 1 1 bZIP transcription factor Mito_fiss_reg PF05308.11 EEA26338.1 - 0.00046 20.3 13.4 0.00058 20.0 12.3 1.9 1 1 1 2 2 2 1 Mitochondrial fission regulator bZIP_2 PF07716.15 EEA26338.1 - 0.0024 17.9 12.2 0.015 15.4 9.2 2.3 1 1 1 2 2 2 2 Basic region leucine zipper YabA PF06156.13 EEA26338.1 - 0.0065 17.1 2.6 0.013 16.2 2.6 1.5 1 0 0 1 1 1 1 Initiation control protein YabA Fez1 PF06818.15 EEA26338.1 - 0.032 14.7 6.5 0.052 14.0 6.5 1.3 1 0 0 1 1 1 0 Fez1 BMFP PF04380.13 EEA26338.1 - 0.048 14.1 1.6 0.048 14.1 1.6 1.9 2 0 0 2 2 2 0 Membrane fusogenic activity FapA PF03961.13 EEA26338.1 - 0.31 9.6 2.9 0.4 9.2 2.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2937 PF11157.8 EEA26338.1 - 0.43 10.3 3.7 0.66 9.7 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) IFT57 PF10498.9 EEA26338.1 - 0.53 9.2 7.2 0.74 8.7 7.2 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF629 PF04780.12 EEA26338.1 - 0.54 8.7 3.5 0.73 8.3 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF629) V_ATPase_I PF01496.19 EEA26338.1 - 0.92 7.3 3.2 1.3 6.9 3.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 EEA26338.1 - 1.4 7.8 8.7 1.9 7.3 8.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein GWT1 PF06423.12 EEA26339.1 - 3.7e-40 137.5 0.7 3.7e-40 137.5 0.7 2.2 2 1 0 2 2 2 1 GWT1 DUF5562 PF17717.1 EEA26339.1 - 0.053 13.5 0.9 0.23 11.4 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5562) PDR_CDR PF06422.12 EEA26339.1 - 0.41 10.6 0.1 0.41 10.6 0.1 2.3 3 0 0 3 3 3 0 CDR ABC transporter Amidase PF01425.21 EEA26340.1 - 3.9e-81 273.3 0.1 7.8e-81 272.3 0.1 1.4 1 1 0 1 1 1 1 Amidase zf-U1 PF06220.12 EEA26340.1 - 0.029 14.1 0.0 0.082 12.7 0.0 1.8 1 0 0 1 1 1 0 U1 zinc finger PDEase_II PF02112.15 EEA26341.1 - 8.6e-56 189.5 0.0 1.2e-26 93.6 0.0 3.0 3 0 0 3 3 3 3 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 EEA26341.1 - 0.014 14.9 0.1 0.037 13.5 0.1 1.7 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EEA26341.1 - 0.032 14.2 0.6 0.087 12.8 0.6 1.7 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily SPRY PF00622.28 EEA26342.1 - 9.1e-20 71.0 0.0 1.4e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 SPRY domain DoxX PF07681.12 EEA26342.1 - 0.17 12.5 1.0 0.32 11.6 0.4 1.8 2 0 0 2 2 2 0 DoxX PAN_1 PF00024.26 EEA26343.1 - 2.8e-08 33.6 4.5 2e-05 24.5 0.2 2.3 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.6 EEA26343.1 - 0.00038 20.3 8.9 0.0016 18.3 1.8 2.5 2 0 0 2 2 2 2 PAN domain DUF4183 PF13799.6 EEA26344.1 - 0.11 12.3 0.3 0.19 11.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4183) Phage_holin_2_1 PF04971.12 EEA26344.1 - 0.12 12.4 0.1 0.19 11.7 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage P21 holin S Peptidase_M24 PF00557.24 EEA26345.1 - 5.7e-57 192.8 0.3 7e-57 192.5 0.3 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 DnaJ PF00226.31 EEA26347.1 - 1.4e-16 60.3 0.8 3.9e-16 58.9 0.8 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EEA26347.1 - 2.6e-06 26.8 0.0 3.6e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Sec63 Brl domain Imm_superinfect PF14373.6 EEA26347.1 - 0.053 13.4 0.3 0.13 12.2 0.1 1.8 2 0 0 2 2 2 0 Superinfection immunity protein ALO PF04030.14 EEA26348.1 - 5.3e-95 318.2 0.0 7.5e-95 317.7 0.0 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EEA26348.1 - 1.1e-32 112.6 0.1 1.6e-32 112.1 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Zn_clus PF00172.18 EEA26349.1 - 7.6e-09 35.6 11.2 7.6e-09 35.6 11.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4045 PF13254.6 EEA26350.1 - 6.9e-136 454.2 41.1 6.9e-136 454.2 41.1 5.8 4 2 1 5 5 5 1 Domain of unknown function (DUF4045) Gelsolin PF00626.22 EEA26350.1 - 2.7e-08 33.6 0.0 0.014 15.3 0.0 3.7 3 0 0 3 3 3 3 Gelsolin repeat Arf PF00025.21 EEA26351.1 - 9.7e-66 220.5 0.7 1.1e-65 220.4 0.7 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EEA26351.1 - 3.8e-13 49.3 3.4 3e-07 29.9 0.9 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EEA26351.1 - 5.4e-12 46.0 0.1 7.2e-12 45.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EEA26351.1 - 4.7e-11 42.5 0.0 5.5e-11 42.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EEA26351.1 - 3.7e-10 39.6 0.0 4.5e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EEA26351.1 - 3e-08 33.3 0.0 3.7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EEA26351.1 - 7.8e-08 32.4 0.0 1.2e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA26351.1 - 6.6e-05 22.5 0.0 0.0024 17.4 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EEA26351.1 - 0.028 14.0 0.2 0.07 12.7 0.2 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 EEA26351.1 - 0.07 12.7 0.1 1.8 8.1 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain 6PF2K PF01591.18 EEA26351.1 - 0.14 11.4 0.1 0.33 10.2 0.1 1.5 1 1 0 2 2 2 0 6-phosphofructo-2-kinase Acetyltransf_7 PF13508.7 EEA26352.1 - 0.019 15.4 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EEA26352.1 - 0.061 14.0 0.0 0.12 13.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA26352.1 - 0.063 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Zn_clus PF00172.18 EEA26353.1 - 9.7e-11 41.6 7.5 1.9e-10 40.7 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA26353.1 - 0.022 13.8 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain UPF0239 PF06783.11 EEA26353.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) MOZART1 PF12554.8 EEA26353.1 - 0.18 11.6 0.0 1.9 8.3 0.0 2.5 2 0 0 2 2 2 0 Mitotic-spindle organizing gamma-tubulin ring associated Chlam_OMP3 PF03503.13 EEA26353.1 - 0.97 9.8 5.7 4 7.8 5.0 2.3 2 0 0 2 2 2 0 Chlamydia cysteine-rich outer membrane protein 3 TFIIA PF03153.13 EEA26354.1 - 2.1e-79 268.5 0.0 3e-79 268.0 0.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit ANAPC4_WD40 PF12894.7 EEA26355.1 - 3.3e-17 62.5 3.3 5.8e-06 26.5 0.1 4.4 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA26355.1 - 3.4e-16 59.3 17.0 4.9e-05 24.0 0.0 6.6 6 1 1 7 7 7 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EEA26355.1 - 3.7e-06 26.1 0.0 0.00085 18.4 0.0 3.1 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EEA26355.1 - 8.9e-05 22.4 0.2 0.0099 15.8 0.1 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Kelch_5 PF13854.6 EEA26356.1 - 1.4e-25 88.8 0.6 1.4e-06 28.2 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 EEA26356.1 - 7.7e-25 86.6 8.9 3.3e-06 27.0 0.0 4.7 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EEA26356.1 - 4e-22 77.7 4.1 2.3e-05 24.5 0.1 5.0 4 1 1 5 5 5 4 Kelch motif Kelch_2 PF07646.15 EEA26356.1 - 6.3e-21 73.5 2.3 2.9e-06 27.0 0.1 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.25 EEA26356.1 - 5.3e-18 64.3 0.1 6.6e-06 25.6 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 EEA26356.1 - 1.2e-16 60.5 14.7 7.6e-08 32.5 0.1 5.8 7 0 0 7 7 7 4 Galactose oxidase, central domain BTB PF00651.31 EEA26356.1 - 4.7e-09 36.5 0.1 8.4e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Glyco_hydro_1 PF00232.18 EEA26357.1 - 8.2e-156 518.9 0.1 1e-155 518.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Mei5 PF10376.9 EEA26358.1 - 0.018 14.9 3.3 0.037 13.9 3.2 1.6 1 1 0 1 1 1 0 Double-strand recombination repair protein TFIIA PF03153.13 EEA26358.1 - 0.066 13.2 8.5 0.079 12.9 8.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lectin_N PF03954.14 EEA26358.1 - 0.12 12.1 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Sel1 PF08238.12 EEA26359.1 - 3.6e-37 126.0 34.1 2.3e-07 31.2 1.2 11.3 11 0 0 11 11 11 8 Sel1 repeat TPR_7 PF13176.6 EEA26359.1 - 0.056 13.5 7.9 21 5.4 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat OSTbeta PF15048.6 EEA26359.1 - 0.065 13.4 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF1835 PF08874.10 EEA26359.1 - 0.31 11.3 1.9 2.2 8.5 0.3 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF1835) RNA_pol_Rpb1_1 PF04997.12 EEA26360.1 - 7.8e-110 367.1 0.0 1.2e-109 366.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EEA26360.1 - 3.5e-104 348.0 0.2 5.2e-104 347.4 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EEA26360.1 - 3.6e-74 248.5 0.0 8e-74 247.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EEA26360.1 - 1.4e-64 217.5 0.7 2.9e-64 216.4 0.7 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EEA26360.1 - 3.6e-48 163.5 0.0 9e-48 162.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EEA26360.1 - 6.5e-46 155.7 7.9 1.3e-45 154.7 7.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EEA26360.1 - 4.8e-36 123.0 0.2 1.1e-35 121.9 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EEA26360.1 - 3.8e-13 49.0 178.2 0.027 14.8 6.4 13.9 12 1 1 13 13 13 11 RNA polymerase Rpb1 C-terminal repeat SMBP PF16785.5 EEA26360.1 - 0.004 17.4 2.3 0.55 10.5 0.4 2.6 2 0 0 2 2 2 2 Small metal-binding protein WD40 PF00400.32 EEA26361.1 - 1.2e-14 54.4 8.3 4.8e-05 24.0 0.2 5.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26361.1 - 1.8e-09 37.7 0.6 5e-05 23.5 0.0 4.5 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA26361.1 - 0.00022 21.2 0.0 0.92 9.4 0.0 2.6 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EEA26361.1 - 0.095 11.2 0.0 0.38 9.2 0.0 1.9 1 1 0 2 2 2 0 Cytochrome D1 heme domain Peptidase_C3 PF00548.20 EEA26361.1 - 0.095 12.6 0.0 0.31 10.9 0.0 1.6 1 1 1 2 2 2 0 3C cysteine protease (picornain 3C) Methyltransf_23 PF13489.6 EEA26362.1 - 2.1e-16 60.2 0.0 3.7e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA26362.1 - 4.1e-08 33.8 0.0 9.6e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA26362.1 - 2.8e-05 24.7 0.0 6.7e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA26362.1 - 0.00015 22.4 0.0 0.0006 20.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA26362.1 - 0.0017 17.9 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EEA26362.1 - 0.0053 16.6 0.0 0.0098 15.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA26362.1 - 0.018 14.5 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EEA26362.1 - 0.021 14.3 0.0 0.021 14.3 0.0 2.0 3 0 0 3 3 2 0 Putative methyltransferase FtsJ PF01728.19 EEA26362.1 - 0.028 14.5 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EEA26362.1 - 0.06 12.7 0.0 0.26 10.6 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EEA26362.1 - 0.065 12.5 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_16 PF10294.9 EEA26362.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase WD40 PF00400.32 EEA26363.1 - 5.3e-12 46.1 0.0 0.07 14.0 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26363.1 - 0.00082 19.6 0.0 9.8 6.6 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EEA26363.1 - 0.013 14.3 0.0 4 6.1 0.0 2.3 2 0 0 2 2 2 0 Nup133 N terminal like Macoilin PF09726.9 EEA26364.1 - 9.7 4.6 31.0 12 4.3 31.0 1.1 1 0 0 1 1 1 0 Macoilin family Thg1C PF14413.6 EEA26365.1 - 1.6e-53 180.0 0.5 2.1e-53 179.6 0.5 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.12 EEA26365.1 - 8.9e-48 161.4 0.2 3.5e-37 127.2 0.0 2.4 1 1 1 2 2 2 2 tRNAHis guanylyltransferase fn3 PF00041.21 EEA26366.1 - 3.8e-05 23.9 0.0 0.00021 21.5 0.0 2.3 2 0 0 2 2 2 1 Fibronectin type III domain ALIX_LYPXL_bnd PF13949.6 EEA26366.1 - 0.0049 16.2 31.3 0.012 15.0 31.3 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Taxilin PF09728.9 EEA26366.1 - 5 6.2 48.7 0.53 9.4 0.5 2.7 2 1 0 2 2 2 0 Myosin-like coiled-coil protein Leu_zip PF15294.6 EEA26366.1 - 7.3 6.0 39.0 0.57 9.7 32.0 2.0 1 1 1 2 2 2 0 Leucine zipper rhaM PF05336.13 EEA26367.1 - 2.9e-36 123.8 0.1 3.3e-36 123.6 0.1 1.0 1 0 0 1 1 1 1 L-rhamnose mutarotase Mg-por_mtran_C PF07109.11 EEA26367.1 - 0.062 13.7 0.0 0.078 13.3 0.0 1.2 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus LNS2 PF08235.13 EEA26368.1 - 1.6e-96 322.1 0.0 2.3e-96 321.6 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EEA26368.1 - 1.5e-42 143.6 0.0 4.4e-42 142.2 0.0 1.8 2 0 0 2 2 2 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 EEA26368.1 - 0.0082 15.8 0.1 0.24 11.0 0.0 2.6 3 0 0 3 3 3 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Herpes_LMP2 PF07415.11 EEA26368.1 - 0.61 8.8 2.8 1 8.0 2.8 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein TFIID-31kDa PF02291.15 EEA26369.1 - 7.2e-45 152.0 0.0 9.6e-45 151.6 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Cmc1 PF08583.10 EEA26370.1 - 7.2e-17 61.2 3.2 1.3e-16 60.3 3.2 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 EEA26370.1 - 0.0013 18.8 0.4 0.0022 18.1 0.4 1.4 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.13 EEA26370.1 - 0.0027 17.4 1.3 0.0043 16.7 1.3 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CX9C PF16860.5 EEA26370.1 - 0.015 15.3 0.1 0.027 14.5 0.1 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX17 PF05051.13 EEA26370.1 - 0.044 14.1 1.0 11 6.4 0.0 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Utp11 PF03998.13 EEA26371.1 - 3.6e-60 203.9 34.6 5.3e-60 203.4 34.6 1.2 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 EEA26371.1 - 0.089 12.1 1.7 0.27 10.5 0.2 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Histidinol_dh PF00815.20 EEA26372.1 - 1e-162 541.9 3.6 1.5e-162 541.3 3.6 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EEA26372.1 - 2.2e-24 85.1 0.3 4.8e-24 84.0 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EEA26372.1 - 9.9e-16 58.0 0.1 4.6e-15 55.8 0.1 2.3 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase BORCS7 PF16088.5 EEA26372.1 - 0.083 13.2 0.4 0.3 11.4 0.1 2.1 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 Glyco_hydro_47 PF01532.20 EEA26373.1 - 3.3e-135 451.5 0.0 3.7e-135 451.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 NmrA PF05368.13 EEA26374.1 - 6.8e-31 107.6 0.1 9.2e-31 107.2 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA26374.1 - 9.7e-13 48.4 0.0 1.2e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA26374.1 - 2.3e-07 30.5 0.0 4.6e-07 29.5 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EEA26374.1 - 2.6e-05 24.2 0.0 0.00012 22.0 0.0 1.9 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EEA26374.1 - 0.0003 19.9 0.0 0.00053 19.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA26374.1 - 0.0012 18.4 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EEA26374.1 - 0.051 13.0 0.1 0.07 12.6 0.1 1.2 1 0 0 1 1 1 0 short chain dehydrogenase DapB_N PF01113.20 EEA26374.1 - 0.061 13.4 0.0 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EEA26374.1 - 0.12 12.9 0.2 0.25 11.9 0.2 1.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 EEA26374.1 - 0.18 10.9 0.1 0.43 9.6 0.1 1.6 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Fungal_trans PF04082.18 EEA26375.1 - 3.6e-14 52.4 0.0 7.5e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26375.1 - 2e-06 27.8 13.4 3.6e-06 27.0 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDC45 PF02724.14 EEA26378.1 - 2.6e-242 805.7 9.4 3.3e-240 798.8 9.4 3.0 1 1 0 1 1 1 1 CDC45-like protein Cwf_Cwc_15 PF04889.12 EEA26378.1 - 0.00037 20.3 8.8 0.00037 20.3 8.8 2.3 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein DUF4604 PF15377.6 EEA26378.1 - 0.13 12.7 20.2 0.65 10.4 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) BUD22 PF09073.10 EEA26378.1 - 0.23 10.8 30.2 0.095 12.0 14.8 2.1 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 EEA26378.1 - 0.65 8.1 25.1 0.086 11.0 10.6 2.1 2 0 0 2 2 2 0 Nop14-like family PNISR PF15996.5 EEA26378.1 - 1.2 9.4 17.1 0.019 15.3 5.7 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SDA1 PF05285.12 EEA26378.1 - 1.6 8.1 26.4 1.7 8.0 12.3 2.2 2 0 0 2 2 2 0 SDA1 Spore_coat_CotO PF14153.6 EEA26378.1 - 1.6 8.6 9.3 0.027 14.4 2.2 1.6 2 0 0 2 2 2 0 Spore coat protein CotO FAM60A PF15396.6 EEA26378.1 - 2.1 8.3 8.9 0.067 13.2 2.1 1.8 2 0 0 2 2 2 0 Protein Family FAM60A RR_TM4-6 PF06459.12 EEA26378.1 - 5.2 6.8 12.7 1.3 8.8 7.1 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Peptidase_C13 PF01650.18 EEA26379.1 - 1.1e-40 139.8 0.0 1.5e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family Cnd1_N PF12922.7 EEA26379.1 - 0.16 11.8 0.1 0.28 11.0 0.1 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term MFS_1 PF07690.16 EEA26380.1 - 3.6e-40 138.0 40.2 3.6e-40 138.0 40.2 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA26380.1 - 2.2e-13 49.5 18.6 3.1e-13 49.0 18.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA26380.1 - 8.5e-09 34.8 7.2 8.5e-09 34.8 7.2 4.2 2 2 1 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 EEA26380.1 - 2.2 6.5 11.1 1.1 7.5 7.9 2.3 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2583 PF10762.9 EEA26380.1 - 2.6 8.5 8.8 3.4 8.2 0.2 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2583) FAD_binding_3 PF01494.19 EEA26381.1 - 8.7e-21 74.5 0.0 6.8e-20 71.6 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EEA26381.1 - 0.00026 20.2 0.1 0.58 9.1 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 EEA26381.1 - 0.0015 18.7 0.1 0.0042 17.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EEA26381.1 - 0.0035 16.6 0.0 0.12 11.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA26381.1 - 0.062 12.9 0.0 0.14 11.7 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EEA26381.1 - 0.071 11.9 0.0 1.1 8.0 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 EEA26381.1 - 0.08 12.2 0.2 0.49 9.6 0.0 2.1 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Homeobox_KN PF05920.11 EEA26382.1 - 2.8e-16 59.1 0.9 2.8e-16 59.1 0.9 2.0 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EEA26382.1 - 2.5e-05 24.0 0.4 6.2e-05 22.8 0.4 1.7 1 0 0 1 1 1 1 Homeodomain zf-C2H2 PF00096.26 EEA26382.1 - 9.4e-05 22.7 11.0 0.35 11.4 0.2 4.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA26382.1 - 0.033 15.0 0.7 0.033 15.0 0.7 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA26382.1 - 7.7 7.1 7.6 43 4.8 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger double domain Aldedh PF00171.22 EEA26383.1 - 1.9e-184 613.5 0.4 2.2e-184 613.3 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family UQ_con PF00179.26 EEA26385.1 - 7.7e-13 48.3 0.1 1.5e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA26385.1 - 0.022 15.0 0.2 0.042 14.1 0.2 1.4 1 0 0 1 1 1 0 RWD domain 2OG-FeII_Oxy_2 PF13532.6 EEA26387.1 - 8e-33 114.3 0.3 1.2e-32 113.7 0.3 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CUE PF02845.16 EEA26387.1 - 1.2e-06 28.0 0.0 3e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 CUE domain Lbh PF15317.6 EEA26387.1 - 0.023 15.5 0.2 0.066 14.1 0.2 1.7 1 0 0 1 1 1 0 Cardiac transcription factor regulator, Developmental protein WD40 PF00400.32 EEA26388.1 - 3.4e-17 62.5 15.6 0.0012 19.6 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Ccdc124 PF06244.12 EEA26389.1 - 9.7e-28 97.3 18.6 6.7e-27 94.6 18.6 2.1 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 DUF2020 PF09449.10 EEA26389.1 - 0.33 10.8 4.0 0.66 9.8 4.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2020) Cupin_8 PF13621.6 EEA26390.1 - 1.7e-32 113.1 0.0 6e-32 111.3 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EEA26390.1 - 7.4e-07 28.9 0.0 0.0028 17.2 0.0 2.4 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 EEA26390.1 - 0.041 14.3 0.0 0.098 13.1 0.0 1.7 1 0 0 1 1 1 0 JmjC domain, hydroxylase GTP1_OBG PF01018.22 EEA26391.1 - 4.4e-38 130.3 5.9 2e-30 105.5 6.0 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EEA26391.1 - 6.2e-22 77.8 0.0 9.9e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA26391.1 - 2.9e-07 30.2 0.1 6.4e-07 29.0 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 EEA26391.1 - 0.031 14.8 0.8 0.27 11.7 0.0 2.3 2 0 0 2 2 2 0 ABC transporter GTP_EFTU PF00009.27 EEA26391.1 - 0.068 12.7 0.0 14 5.2 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MeaB PF03308.16 EEA26391.1 - 0.12 11.3 0.0 0.44 9.5 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 EEA26391.1 - 0.14 11.8 0.0 1.6 8.3 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MFS_1 PF07690.16 EEA26392.1 - 6.9e-36 123.9 22.7 6.9e-36 123.9 22.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA26392.1 - 3e-09 36.2 4.9 3e-09 36.2 4.9 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EEA26392.1 - 9.6e-05 21.4 0.1 9.6e-05 21.4 0.1 3.1 2 2 1 3 3 3 1 MFS_1 like family TRI12 PF06609.13 EEA26392.1 - 0.00019 20.0 1.1 0.0003 19.4 1.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EEA26392.1 - 1.2 7.5 7.7 1.8 6.8 0.5 2.4 2 1 0 2 2 2 0 Transmembrane secretion effector Fungal_trans PF04082.18 EEA26393.1 - 3.7e-26 91.8 0.0 6.3e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26393.1 - 8.2e-08 32.2 12.2 1.3e-07 31.6 12.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S10 PF00338.22 EEA26393.1 - 0.0079 16.4 0.2 0.018 15.3 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DnaJ PF00226.31 EEA26394.1 - 7.2e-22 77.3 1.8 8.9e-22 77.0 0.2 2.0 2 0 0 2 2 2 1 DnaJ domain Adenylsucc_synt PF00709.21 EEA26395.1 - 4.1e-169 563.0 0.0 4.7e-169 562.8 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase KHA PF11834.8 EEA26395.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel Glyco_hydro_18 PF00704.28 EEA26398.1 - 1.6e-47 162.8 1.6 2.6e-47 162.1 1.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EEA26398.1 - 3.3e-08 33.5 0.0 0.0021 18.1 0.0 3.0 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EEA26398.1 - 0.00013 22.3 6.6 0.00013 22.3 6.6 5.3 4 1 1 5 5 5 1 Chitin recognition protein DUF1579 PF07617.11 EEA26398.1 - 0.023 14.6 0.4 0.051 13.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1579) Aldedh PF00171.22 EEA26399.1 - 5.7e-130 433.9 0.2 6.8e-130 433.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA26399.1 - 0.23 10.9 0.0 0.67 9.4 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) MFS_1 PF07690.16 EEA26401.1 - 1e-15 57.5 40.3 1e-15 57.5 40.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA26401.1 - 3.5e-07 29.5 11.8 3.5e-07 29.5 11.8 2.5 3 1 0 3 3 3 1 Sugar (and other) transporter Peptidase_A8 PF01252.18 EEA26401.1 - 0.0047 17.2 3.8 0.0047 17.2 3.8 2.8 3 1 1 4 4 4 1 Signal peptidase (SPase) II UPF0093 PF03653.13 EEA26401.1 - 0.62 10.3 5.4 3.5 7.9 5.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0093) DEAD PF00270.29 EEA26402.1 - 4.5e-42 143.8 0.0 8.1e-42 143.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA26402.1 - 5.9e-24 84.6 0.0 5e-23 81.6 0.1 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA26402.1 - 1.6e-06 28.2 0.0 2.7e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA26402.1 - 0.012 14.8 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 EEA26402.1 - 0.11 11.8 0.8 0.29 10.4 0.0 1.8 2 0 0 2 2 2 0 SecA DEAD-like domain Abhydrolase_2 PF02230.16 EEA26403.1 - 2.4e-10 40.6 0.0 9.3e-10 38.7 0.0 1.9 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Zot PF05707.12 EEA26404.1 - 0.003 17.2 0.0 0.0065 16.1 0.0 1.5 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) DUF87 PF01935.17 EEA26404.1 - 0.01 15.9 0.0 0.01 15.9 0.0 2.3 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_22 PF13401.6 EEA26404.1 - 0.064 13.5 0.0 21 5.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain TFIIA PF03153.13 EEA26407.1 - 0.065 13.2 0.5 0.064 13.3 0.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BetaGal_dom4_5 PF13364.6 EEA26412.1 - 4.4e-64 214.1 8.6 2e-36 125.0 0.1 3.6 3 0 0 3 3 3 3 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EEA26412.1 - 9.2e-57 191.8 0.1 1.9e-56 190.7 0.1 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 Glyco_hydro_35 PF01301.19 EEA26412.1 - 1.8e-27 96.8 0.1 2.9e-27 96.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom3 PF13363.6 EEA26412.1 - 1.7e-22 78.8 0.2 4.4e-22 77.4 0.2 1.8 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 Glyco_hydro_35 PF01301.19 EEA26413.1 - 8.9e-62 209.5 0.0 1e-61 209.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Cellulase PF00150.18 EEA26413.1 - 0.019 14.4 0.0 0.041 13.3 0.0 1.6 1 1 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) SLATT_fungal PF18142.1 EEA26414.1 - 1.1e-32 112.6 0.6 2.4e-32 111.4 0.1 1.8 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain DUF948 PF06103.11 EEA26414.1 - 0.00041 20.5 0.1 0.0054 17.0 0.0 2.3 2 1 0 2 2 2 1 Bacterial protein of unknown function (DUF948) COG2 PF06148.11 EEA26414.1 - 0.0096 16.0 2.9 0.032 14.3 0.3 2.4 2 1 1 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 EEA26414.1 - 0.015 15.3 0.4 0.08 13.0 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Lebercilin PF15619.6 EEA26414.1 - 0.037 13.7 0.6 0.11 12.1 0.6 1.9 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease IFT57 PF10498.9 EEA26414.1 - 0.042 12.8 0.2 0.042 12.8 0.2 1.5 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Golgin_A5 PF09787.9 EEA26414.1 - 0.37 10.2 6.7 0.024 14.1 1.5 1.6 2 0 0 2 2 2 0 Golgin subfamily A member 5 Apolipoprotein PF01442.18 EEA26414.1 - 2.7 7.8 7.8 5.6 6.8 7.8 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain ABC_tran_CTD PF16326.5 EEA26415.1 - 0.0002 21.5 3.5 0.0002 21.5 3.5 6.7 3 2 3 7 7 7 1 ABC transporter C-terminal domain CorA PF01544.18 EEA26415.1 - 0.0016 17.8 5.1 0.0016 17.8 5.1 3.6 3 1 1 4 4 4 1 CorA-like Mg2+ transporter protein EzrA PF06160.12 EEA26415.1 - 0.014 13.6 43.4 0.018 13.3 14.0 3.3 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA MtrG PF04210.13 EEA26415.1 - 0.14 12.1 3.2 14 5.6 0.1 3.8 3 1 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Fib_alpha PF08702.10 EEA26415.1 - 0.15 12.2 35.1 0.038 14.2 3.6 4.4 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Osmo_CC PF08946.10 EEA26415.1 - 1.3 9.4 21.3 0.65 10.3 1.9 4.9 4 1 0 4 4 4 0 Osmosensory transporter coiled coil CENP-F_leu_zip PF10473.9 EEA26415.1 - 2.9 7.9 51.0 0.053 13.6 16.7 4.0 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Zw10 PF06248.13 EEA26415.1 - 4.7 5.6 22.0 0.01 14.5 7.4 2.7 2 1 1 3 3 3 0 Centromere/kinetochore Zw10 RNA_pol_Rpb5_C PF01191.19 EEA26416.1 - 8.7e-34 115.2 0.1 1.5e-33 114.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EEA26416.1 - 1.5e-27 96.0 0.0 2.2e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EEA26416.1 - 0.0015 18.5 0.0 0.0036 17.3 0.0 1.6 2 0 0 2 2 2 1 Restriction endonuclease Sld3_N PF18523.1 EEA26416.1 - 0.15 12.2 0.2 0.36 11.0 0.2 1.6 1 0 0 1 1 1 0 Sld3 N-terminal domain RNA_pol_Rpb5_C PF01191.19 EEA26417.1 - 5.4e-34 115.9 0.1 7.8e-34 115.4 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain Mrr_cat PF04471.12 EEA26417.1 - 0.0012 18.9 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease RNA_pol_Rpb5_N PF03871.14 EEA26417.1 - 0.0022 18.5 0.0 0.0038 17.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Sld3_N PF18523.1 EEA26417.1 - 0.1 12.7 0.2 0.19 11.8 0.2 1.4 1 0 0 1 1 1 0 Sld3 N-terminal domain DUF2840 PF11000.8 EEA26418.1 - 0.097 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) Methyltr_RsmB-F PF01189.17 EEA26419.1 - 8.4e-35 120.2 0.0 7.3e-27 94.3 0.0 3.1 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EEA26419.1 - 0.2 11.8 0.0 0.41 10.7 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Clr2_transil PF16761.5 EEA26420.1 - 0.32 11.9 2.5 0.47 11.3 1.2 1.9 1 1 1 2 2 2 0 Transcription-silencing protein, cryptic loci regulator Clr2 AMP-binding PF00501.28 EEA26421.1 - 3.2e-84 283.0 0.0 4e-84 282.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA26421.1 - 1.1e-15 58.4 0.2 3.4e-15 56.8 0.3 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF3039 PF11238.8 EEA26421.1 - 0.079 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) bZIP_1 PF00170.21 EEA26422.1 - 7.3e-11 42.0 4.0 7.3e-11 42.0 4.0 1.9 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EEA26422.1 - 0.0001 22.3 5.9 0.00021 21.3 5.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper CDC45 PF02724.14 EEA26422.1 - 0.086 11.1 6.9 0.089 11.1 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3439 PF11921.8 EEA26422.1 - 0.13 12.2 1.9 0.25 11.3 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) bZIP_Maf PF03131.17 EEA26422.1 - 0.21 12.2 12.8 0.077 13.5 9.8 1.8 1 1 1 2 2 2 0 bZIP Maf transcription factor Aminotran_1_2 PF00155.21 EEA26423.1 - 5.7e-61 206.7 0.0 7.2e-61 206.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA26423.1 - 0.008 14.7 0.0 0.023 13.2 0.0 1.7 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.13 EEA26423.1 - 0.16 10.8 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 Allinase Tam41_Mmp37 PF09139.11 EEA26424.1 - 1.7e-132 441.8 0.0 2.1e-132 441.5 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial DUF1525 PF07511.11 EEA26424.1 - 0.12 12.6 0.3 21 5.3 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1525) BIR PF00653.21 EEA26425.1 - 5e-47 158.4 4.9 8.8e-23 80.8 0.1 2.6 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C2H2_jaz PF12171.8 EEA26426.1 - 2.1e-08 34.2 0.4 3.9e-08 33.4 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EEA26426.1 - 5e-06 26.7 0.5 9.1e-06 25.9 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EEA26426.1 - 0.00095 19.5 0.4 0.0016 18.8 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EEA26426.1 - 0.051 13.9 0.7 0.43 10.9 0.1 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) F-box-like PF12937.7 EEA26427.1 - 9.9e-05 22.2 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA26427.1 - 0.0026 17.6 0.3 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 F-box domain Amidohydro_1 PF01979.20 EEA26428.1 - 9.9e-14 51.4 0.2 1.9e-13 50.5 0.1 1.5 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA26428.1 - 2.4e-06 27.3 0.0 8.6e-06 25.5 0.0 2.0 2 1 0 2 2 2 1 Amidohydrolase family HemY_N PF07219.13 EEA26429.1 - 0.039 14.1 0.2 0.039 14.1 0.2 2.2 2 0 0 2 2 2 0 HemY protein N-terminus Pyrid_ox_like PF16242.5 EEA26430.1 - 5.4e-17 61.8 0.0 8.3e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 EEA26430.1 - 2.2e-05 24.5 0.0 3.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 EEA26430.1 - 0.04 13.6 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 Putative FMN-binding domain TFIID-18kDa PF02269.16 EEA26431.1 - 8.8e-33 112.2 0.6 1.1e-31 108.7 0.3 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TAFII28 PF04719.14 EEA26431.1 - 0.037 14.1 0.1 0.095 12.8 0.0 1.8 2 0 0 2 2 2 0 hTAFII28-like protein conserved region TP_methylase PF00590.20 EEA26432.1 - 4.6e-25 88.8 0.2 8.1e-25 88.0 0.2 1.4 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases UDPG_MGDP_dh_N PF03721.14 EEA26432.1 - 0.17 11.5 0.0 12 5.4 0.0 2.7 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Clat_adaptor_s PF01217.20 EEA26433.1 - 9.2e-56 187.7 2.0 1.1e-55 187.5 2.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DFF-C PF09033.10 EEA26434.1 - 0.17 11.8 0.0 0.24 11.3 0.0 1.1 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain DUF1601 PF07671.11 EEA26434.1 - 0.19 11.6 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1601) Ist1 PF03398.14 EEA26435.1 - 7.8e-45 152.7 3.0 1.1e-21 77.5 1.6 2.2 2 0 0 2 2 2 2 Regulator of Vps4 activity in the MVB pathway SAPS PF04499.15 EEA26435.1 - 8.2e-05 21.6 0.3 0.00012 21.0 0.3 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 EEA26435.1 - 0.072 12.9 1.9 0.15 11.9 1.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5327 PF17261.2 EEA26435.1 - 8.7 7.2 8.8 1.9e+02 2.8 8.8 2.6 1 1 0 1 1 1 0 Family of unknown function (DUF5327) CN_hydrolase PF00795.22 EEA26436.1 - 5.6e-44 150.4 0.0 7.5e-44 150.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EEA26436.1 - 1e-25 90.3 0.0 2.7e-25 88.9 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 EEA26436.1 - 0.075 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase DUF1338 PF07063.13 EEA26437.1 - 2.1e-108 362.4 0.0 2.7e-108 362.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) SUN PF03856.13 EEA26439.1 - 3.7e-76 255.8 11.3 5.8e-76 255.2 11.3 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) NPR3 PF03666.13 EEA26439.1 - 1.2 7.8 6.6 1.5 7.5 6.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SOG2 PF10428.9 EEA26439.1 - 2.9 7.0 33.5 4 6.5 33.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 EEA26439.1 - 4.3 6.1 19.1 7.6 5.3 19.1 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain BTB PF00651.31 EEA26440.1 - 9.4e-09 35.5 0.0 1.7e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Cupredoxin_1 PF13473.6 EEA26441.1 - 0.077 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Cupredoxin-like domain Phosphoesterase PF04185.14 EEA26442.1 - 6.2e-67 226.3 0.4 7.7e-67 226.0 0.4 1.1 1 0 0 1 1 1 1 Phosphoesterase family DUF5562 PF17717.1 EEA26442.1 - 0.013 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5562) CENP-X PF09415.10 EEA26443.1 - 4.1e-29 100.7 0.0 1.1e-28 99.3 0.0 1.8 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 EEA26443.1 - 0.0084 16.4 0.1 0.0084 16.4 0.1 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Senescence_reg PF04520.13 EEA26443.1 - 0.06 14.2 12.1 0.079 13.8 12.1 1.3 1 0 0 1 1 1 0 Senescence regulator Peptidase_S64 PF08192.11 EEA26443.1 - 0.14 10.7 9.5 0.15 10.5 9.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Herpes_DNAp_acc PF04929.12 EEA26443.1 - 0.3 10.0 13.5 0.39 9.7 13.5 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor SPX PF03105.19 EEA26443.1 - 0.32 10.9 19.3 0.38 10.6 19.3 1.0 1 0 0 1 1 1 0 SPX domain GET2 PF08690.10 EEA26443.1 - 0.36 10.5 12.0 0.53 9.9 12.0 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 PLN_propep PF16485.5 EEA26443.1 - 0.68 9.7 2.8 16 5.3 0.2 3.3 3 0 0 3 3 3 0 Protealysin propeptide Hamartin PF04388.12 EEA26443.1 - 2.1 6.9 14.0 2.5 6.7 14.0 1.0 1 0 0 1 1 1 0 Hamartin protein ORC6 PF05460.13 EEA26443.1 - 2.4 7.4 16.0 3.2 6.9 16.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Macoilin PF09726.9 EEA26443.1 - 2.8 6.4 12.4 3.1 6.2 12.4 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EEA26443.1 - 2.9 6.6 13.7 3.6 6.3 13.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EEA26443.1 - 7.9 5.1 12.1 8.7 5.0 12.1 1.1 1 0 0 1 1 1 0 Presenilin DUF4551 PF15087.6 EEA26443.1 - 8.3 5.1 12.5 9.9 4.9 12.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Nucleo_P87 PF07267.11 EEA26443.1 - 10 4.9 12.6 14 4.4 12.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Mis12 PF05859.12 EEA26444.1 - 1.3e-47 161.3 0.1 2.2e-47 160.5 0.1 1.4 1 0 0 1 1 1 1 Mis12 protein Fungal_trans PF04082.18 EEA26447.1 - 1.7e-11 43.7 0.1 2.9e-11 42.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26447.1 - 1.9e-06 27.9 12.3 3.3e-06 27.1 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA26448.1 - 4.8e-30 104.7 42.8 4.8e-30 104.7 42.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily ELK PF03789.13 EEA26448.1 - 0.041 14.0 1.6 0.094 12.8 0.0 2.1 2 0 0 2 2 2 0 ELK domain AIM3 PF17096.5 EEA26449.1 - 0.0089 16.9 0.1 0.0089 16.9 0.1 5.7 5 1 2 7 7 7 1 Altered inheritance of mitochondria protein 3 Lipase_3 PF01764.25 EEA26450.1 - 2e-06 27.7 0.0 5.1e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EEA26450.1 - 0.01 15.1 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 UPF0227 PF05728.12 EEA26450.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) AMP-binding PF00501.28 EEA26451.1 - 0 1052.3 0.0 1.7e-66 224.6 0.0 5.2 5 0 0 5 5 5 5 AMP-binding enzyme Condensation PF00668.20 EEA26451.1 - 2.5e-190 633.0 0.0 2.2e-40 138.7 0.0 5.6 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 EEA26451.1 - 4.3e-55 183.9 10.8 3.8e-13 49.6 0.1 6.2 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA26451.1 - 7.8e-06 26.8 0.0 0.43 11.6 0.0 3.5 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EEA26451.1 - 0.0007 18.6 1.4 1.8 7.3 0.0 4.8 5 0 0 5 5 5 1 GH3 auxin-responsive promoter Trypsin PF00089.26 EEA26451.1 - 0.15 11.9 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Trypsin DIOX_N PF14226.6 EEA26452.1 - 1.1e-24 87.4 0.0 2e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA26452.1 - 2.6e-10 40.7 0.0 7.1e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EEA26453.1 - 4.1e-13 49.0 51.0 1.6e-12 47.1 27.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Bap31 PF05529.12 EEA26453.1 - 0.032 14.1 1.0 0.032 14.1 1.0 2.8 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region DUF973 PF06157.11 EEA26453.1 - 0.13 11.3 2.2 0.36 9.9 2.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF973) DUF1275 PF06912.11 EEA26454.1 - 5.6e-44 150.4 12.2 6.6e-44 150.1 12.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) ABC2_membrane_6 PF06182.11 EEA26454.1 - 0.0094 15.7 2.6 0.019 14.7 2.6 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF2070 PF09843.9 EEA26454.1 - 1 7.5 7.1 1.3 7.2 7.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ELO PF01151.18 EEA26455.1 - 1e-83 280.7 3.5 1.2e-83 280.4 3.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Flagellin_N PF00669.20 EEA26455.1 - 0.61 10.2 5.5 5.1 7.2 3.0 2.2 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region DUF4381 PF14316.6 EEA26455.1 - 0.78 10.0 3.7 1.1 9.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) HEPN_RnaseLS PF18869.1 EEA26456.1 - 0.22 11.7 0.0 0.41 10.8 0.0 1.4 1 0 0 1 1 1 0 RnaseLS-like HEPN Hexapep PF00132.24 EEA26457.1 - 8.4e-08 31.7 6.1 0.00054 19.6 1.1 2.8 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EEA26457.1 - 1.9e-05 23.8 1.8 0.0076 15.2 0.1 2.2 1 1 1 2 2 2 2 L-fucokinase NTP_transf_3 PF12804.7 EEA26457.1 - 0.0016 18.8 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 EEA26457.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase DUF4954 PF16314.5 EEA26457.1 - 0.19 9.8 1.0 0.48 8.5 1.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EEA26457.1 - 5.1 6.9 8.4 11 5.8 0.8 3.1 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase BCNT PF07572.12 EEA26458.1 - 2.7e-27 94.6 0.6 7.8e-27 93.2 0.6 1.9 1 0 0 1 1 1 1 Bucentaur or craniofacial development Ribonuclease_T2 PF00445.18 EEA26459.1 - 7.8e-39 133.8 0.4 1.1e-38 133.3 0.4 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family MFS_1 PF07690.16 EEA26460.1 - 2.8e-21 75.8 27.7 2.8e-21 75.8 27.7 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily zf-C2H2 PF00096.26 EEA26461.1 - 6.4e-09 35.8 10.4 0.00041 20.6 3.6 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA26461.1 - 3.8e-05 23.9 2.9 3.8e-05 23.9 2.9 3.4 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA26461.1 - 5.4e-05 23.7 6.5 0.0097 16.7 2.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EEA26461.1 - 0.0006 20.4 3.6 0.35 11.5 0.2 2.4 1 1 1 2 2 2 2 FOXP coiled-coil domain Sina PF03145.16 EEA26461.1 - 0.082 12.9 1.5 0.12 12.3 1.5 1.2 1 0 0 1 1 1 0 Seven in absentia protein family zf-C2H2_6 PF13912.6 EEA26461.1 - 0.41 10.7 9.0 2.5 8.2 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Spt20 PF12090.8 EEA26463.1 - 3.3e-60 203.6 5.8 3.3e-60 203.6 5.8 6.9 4 2 2 6 6 6 1 Spt20 family Shadoo PF14999.6 EEA26464.1 - 7 6.8 10.5 1.9 8.6 5.7 2.4 2 1 0 3 3 3 0 Shadow of prion protein, neuroprotective Gly_transf_sug PF04488.15 EEA26465.1 - 1.5e-11 44.7 0.2 5.1e-11 43.1 0.1 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EEA26465.1 - 0.00059 19.3 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 EEA26465.1 - 0.022 14.1 0.3 0.044 13.1 0.0 1.6 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain DDE_Tnp_1_7 PF13843.6 EEA26466.1 - 1.2e-52 179.4 0.1 1.5e-52 179.1 0.1 1.1 1 0 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA26466.1 - 6.9e-12 46.0 9.4 1.6e-11 44.8 9.4 1.7 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon TruD PF01142.18 EEA26467.1 - 1.4e-66 225.1 0.3 6.3e-62 209.7 0.1 3.9 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) EcKinase PF02958.20 EEA26467.1 - 0.092 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase PHD PF00628.29 EEA26469.1 - 2.6e-08 33.6 6.8 4.3e-08 32.9 6.8 1.4 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.6 EEA26469.1 - 0.11 12.9 2.8 0.48 10.9 2.8 2.1 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx zf-CSL PF05207.13 EEA26469.1 - 0.16 11.7 0.4 0.33 10.7 0.4 1.5 1 0 0 1 1 1 0 CSL zinc finger PHD_2 PF13831.6 EEA26469.1 - 0.27 10.8 6.5 0.45 10.1 6.5 1.3 1 0 0 1 1 1 0 PHD-finger APC_u5 PF16630.5 EEA26469.1 - 0.96 10.5 7.2 6.6 7.8 0.2 2.8 2 0 0 2 2 2 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs DUF2293 PF10056.9 EEA26470.1 - 1.4e-27 95.7 0.3 3.9e-27 94.3 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) HTH_16 PF12645.7 EEA26470.1 - 0.0068 16.4 0.1 0.017 15.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain FA_hydroxylase PF04116.13 EEA26471.1 - 4.5e-24 85.3 14.6 4.5e-24 85.3 14.6 1.5 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily TCTP PF00838.17 EEA26472.1 - 1e-58 198.3 0.3 1.2e-58 198.2 0.3 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Cullin PF00888.22 EEA26472.1 - 0.031 12.9 0.1 0.038 12.6 0.1 1.0 1 0 0 1 1 1 0 Cullin family DUF3627 PF12299.8 EEA26472.1 - 0.036 14.1 0.1 0.09 12.9 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3627) Fungal_trans PF04082.18 EEA26473.1 - 3.7e-13 49.1 2.6 1.3e-12 47.3 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26473.1 - 4.3e-10 39.5 9.8 7.2e-10 38.8 9.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MIP-T3_C PF17749.1 EEA26473.1 - 0.046 13.7 1.4 0.13 12.3 1.4 1.7 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region SRP19 PF01922.17 EEA26474.1 - 1.6e-32 112.3 0.0 2.3e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 SRP19 protein Rad60-SLD PF11976.8 EEA26474.1 - 0.13 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Aminotran_3 PF00202.21 EEA26475.1 - 2.8e-91 306.2 0.0 3.3e-91 306.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III ABC_tran PF00005.27 EEA26476.1 - 4.9e-52 176.1 0.0 7.2e-31 107.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA26476.1 - 1.8e-43 149.2 29.2 9.5e-27 94.3 7.6 3.2 3 0 0 3 3 2 2 ABC transporter transmembrane region RsgA_GTPase PF03193.16 EEA26476.1 - 5.2e-07 29.7 0.0 0.005 16.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 EEA26476.1 - 6.2e-07 29.1 0.6 0.11 12.0 0.0 3.7 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA26476.1 - 3.4e-06 26.7 0.7 0.068 12.9 0.0 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EEA26476.1 - 5e-06 26.5 3.8 0.11 12.3 0.1 3.8 4 0 0 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA26476.1 - 8.5e-06 26.4 0.0 0.073 13.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EEA26476.1 - 7.6e-05 23.2 0.3 0.54 10.6 0.4 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA26476.1 - 9.2e-05 22.7 0.1 0.8 10.0 0.0 2.9 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EEA26476.1 - 0.0004 20.4 2.8 0.028 14.5 0.0 2.9 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_25 PF13481.6 EEA26476.1 - 0.00045 19.8 0.0 0.62 9.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EEA26476.1 - 0.00074 19.3 0.0 0.031 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EEA26476.1 - 0.0018 17.3 0.0 0.0036 16.3 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EEA26476.1 - 0.0018 18.5 0.0 0.55 10.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EEA26476.1 - 0.0024 17.0 0.0 1.2 8.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_18 PF13238.6 EEA26476.1 - 0.0051 17.3 0.0 3.9 8.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EEA26476.1 - 0.0062 16.3 0.1 6.6 6.4 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 EEA26476.1 - 0.019 14.3 0.0 2.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Dynamin_N PF00350.23 EEA26476.1 - 0.023 14.8 0.3 0.84 9.7 0.1 2.4 2 0 0 2 2 2 0 Dynamin family DUF87 PF01935.17 EEA26476.1 - 0.028 14.5 0.2 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain cobW PF02492.19 EEA26476.1 - 0.059 13.0 0.8 9 5.8 0.1 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Methyltransf_25 PF13649.6 EEA26476.1 - 0.061 14.0 0.1 4 8.2 0.0 3.1 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 EEA26476.1 - 0.063 14.0 0.1 0.64 10.8 0.0 2.6 1 1 1 2 2 2 0 Methyltransferase domain AAA_15 PF13175.6 EEA26476.1 - 0.069 12.9 0.0 0.42 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EEA26476.1 - 0.071 12.8 0.1 7.1 6.3 0.1 2.7 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 EEA26476.1 - 0.076 12.2 0.1 2.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 EEA26476.1 - 0.094 12.1 0.0 13 5.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 EEA26476.1 - 0.11 12.9 0.0 24 5.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase CbiA PF01656.23 EEA26476.1 - 0.16 12.0 0.0 1.9 8.6 0.0 2.4 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 EEA26476.1 - 0.18 11.7 0.7 5.2 7.0 0.1 2.8 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Bac_export_2 PF01312.19 EEA26476.1 - 0.21 10.7 2.4 1.5 8.0 0.1 2.8 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family AAA_27 PF13514.6 EEA26476.1 - 0.22 11.1 0.2 2.6 7.6 0.0 2.4 3 0 0 3 3 2 0 AAA domain DUF3328 PF11807.8 EEA26477.1 - 0.00027 20.8 0.6 0.00036 20.4 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) AMP-binding PF00501.28 EEA26478.1 - 0 1099.3 0.0 3.5e-75 253.2 0.0 5.2 5 0 0 5 5 5 5 AMP-binding enzyme Condensation PF00668.20 EEA26478.1 - 7.7e-179 595.1 0.2 2.2e-41 142.0 0.1 5.6 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 EEA26478.1 - 2e-53 178.6 3.4 1.7e-11 44.3 0.0 6.2 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA26478.1 - 2e-12 47.9 0.0 0.0055 17.7 0.0 6.1 6 0 0 6 6 6 3 AMP-binding enzyme C-terminal domain DUF2309 PF10070.9 EEA26478.1 - 0.37 9.1 1.3 0.61 8.3 1.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) DUF3328 PF11807.8 EEA26479.1 - 1.3e-34 119.9 0.2 1.7e-34 119.6 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ID PF18543.1 EEA26480.1 - 4.6e-06 26.6 3.5 28 4.8 0.0 6.6 1 1 7 8 8 8 1 Intracellular delivery domain FliC PF12445.8 EEA26480.1 - 2.9e-05 24.4 5.0 1 9.7 0.1 4.0 1 1 3 4 4 4 4 Flagellin protein DUF3660 PF12398.8 EEA26480.1 - 0.00016 21.7 7.1 69 3.6 0.0 7.1 6 2 2 8 8 8 0 Receptor serine/threonine kinase TPR_17 PF13431.6 EEA26480.1 - 0.00027 21.1 0.0 1.5e+02 3.1 0.0 6.2 6 2 0 6 6 6 0 Tetratricopeptide repeat ChW PF07538.11 EEA26480.1 - 0.077 12.9 4.5 2.5e+02 1.7 0.0 5.1 5 0 0 5 5 5 0 Clostridial hydrophobic W Colicin_Ia PF11504.8 EEA26480.1 - 0.75 9.9 4.8 17 5.6 0.1 4.3 1 1 5 6 6 6 0 Colicin Ia DUF3328 PF11807.8 EEA26481.1 - 2.9e-44 151.5 0.5 4e-44 151.0 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EEA26482.1 - 1.4e-19 70.8 5.6 3.2e-19 69.6 5.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_2 PF13347.6 EEA26483.1 - 1.8e-10 40.0 10.8 1.8e-10 40.0 10.8 2.6 3 1 0 3 3 3 1 MFS/sugar transport protein PUCC PF03209.15 EEA26483.1 - 0.00042 19.5 0.6 0.0011 18.1 0.6 1.6 1 0 0 1 1 1 1 PUCC protein DUF4040 PF13244.6 EEA26483.1 - 0.015 15.4 0.8 0.015 15.4 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4040) TMEM138 PF14935.6 EEA26483.1 - 0.035 14.7 3.2 10 6.8 1.3 3.1 2 0 0 2 2 2 0 Transmembrane protein 138 Aminotran_1_2 PF00155.21 EEA26484.1 - 1.2e-62 212.2 0.0 1.4e-62 212.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA26484.1 - 0.00084 18.0 0.0 0.0016 17.1 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EEA26484.1 - 0.0011 17.9 0.0 0.0054 15.7 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA26484.1 - 0.077 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EEA26484.1 - 0.08 12.2 0.0 0.15 11.4 0.0 1.4 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Lyase_aromatic PF00221.19 EEA26485.1 - 5.3e-155 516.6 0.9 6.7e-155 516.3 0.9 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase CPSF73-100_C PF11718.8 EEA26486.1 - 9.1e-77 257.5 0.8 1.4e-76 256.9 0.8 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EEA26486.1 - 2.3e-29 101.9 0.0 5.7e-29 100.6 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 EEA26486.1 - 5.9e-21 75.4 0.2 5.9e-21 75.4 0.2 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EEA26486.1 - 3.5e-15 55.9 0.1 5.9e-15 55.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EEA26486.1 - 7.3e-13 48.3 0.3 2.9e-12 46.4 0.0 2.1 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 EEA26486.1 - 0.00045 20.2 0.1 0.0015 18.4 0.1 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EEA26486.1 - 0.00046 19.8 0.1 0.001 18.6 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TAF4 PF05236.14 EEA26487.1 - 8.2e-30 104.5 0.1 1.4e-28 100.5 0.1 2.1 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Pkinase PF00069.25 EEA26488.1 - 6.5e-51 173.2 0.1 2.6e-50 171.2 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26488.1 - 9.1e-21 74.3 0.1 1.7e-19 70.1 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EEA26488.1 - 0.065 12.6 0.0 0.45 9.8 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family LCE6A PF15858.5 EEA26488.1 - 1.2 9.9 4.5 1.7 9.5 2.0 2.4 2 0 0 2 2 2 0 Late cornified envelope protein 6A family Pkinase PF00069.25 EEA26489.1 - 6.4e-51 173.2 0.1 2.6e-50 171.2 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26489.1 - 9e-21 74.3 0.1 1.7e-19 70.1 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EEA26489.1 - 0.064 12.6 0.0 0.44 9.9 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family LCE6A PF15858.5 EEA26489.1 - 1.2 9.9 4.5 1.7 9.5 2.0 2.4 2 0 0 2 2 2 0 Late cornified envelope protein 6A family Mtc PF03820.17 EEA26490.1 - 2.4e-117 391.4 0.0 2.7e-117 391.3 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier AAL_decarboxy PF03306.13 EEA26491.1 - 1.1e-68 230.9 0.0 1.2e-68 230.7 0.0 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase PHTB1_C PF14728.6 EEA26491.1 - 0.14 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 PTHB1 C-terminus TPP_enzyme_N PF02776.18 EEA26492.1 - 9.2e-44 149.1 0.4 2e-43 148.0 0.4 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EEA26492.1 - 7.6e-38 129.7 0.2 1.5e-36 125.5 0.0 2.4 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA26492.1 - 1.1e-24 86.7 0.0 2.2e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Methyltr_RsmB-F PF01189.17 EEA26494.1 - 5.6e-15 55.5 0.0 6.3e-08 32.5 0.0 2.7 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F IncFII_repA PF02387.15 EEA26494.1 - 0.056 12.7 0.2 0.26 10.5 0.0 2.0 2 0 0 2 2 2 0 IncFII RepA protein family DUF3328 PF11807.8 EEA26495.1 - 4.7e-28 98.5 2.2 6.5e-28 98.0 2.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DIOX_N PF14226.6 EEA26496.1 - 9.2e-24 84.5 0.0 1.7e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA26496.1 - 2.3e-16 60.1 0.0 5e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MAP17 PF15807.5 EEA26497.1 - 0.014 15.6 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 adh_short PF00106.25 EEA26498.1 - 8.2e-41 139.6 0.9 1.1e-40 139.2 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA26498.1 - 3e-37 128.4 0.9 4.4e-37 127.9 0.9 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA26498.1 - 4.8e-14 52.7 0.2 6e-14 52.4 0.2 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA26498.1 - 0.00012 21.3 0.4 0.00015 21.0 0.4 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 EEA26498.1 - 0.0081 15.9 0.5 0.022 14.5 0.5 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Sugar_tr PF00083.24 EEA26499.1 - 3.9e-41 141.4 21.8 2.4e-27 95.9 4.0 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EEA26499.1 - 1.4e-22 80.1 22.9 1.4e-22 80.1 22.9 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF872 PF05915.12 EEA26499.1 - 0.17 12.0 1.5 2.2 8.5 1.2 2.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) RTA1 PF04479.13 EEA26501.1 - 4.2e-49 167.0 4.6 1.4e-47 162.0 4.6 2.1 1 1 0 1 1 1 1 RTA1 like protein FYVE PF01363.21 EEA26503.1 - 2.2e-15 56.5 8.9 3.8e-15 55.8 8.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 EEA26503.1 - 0.02 15.1 9.0 0.02 15.1 9.0 2.1 2 0 0 2 2 2 0 AN1-like Zinc finger Acetyltransf_10 PF13673.7 EEA26504.1 - 4e-05 23.5 0.0 0.42 10.5 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA26504.1 - 9.6e-05 22.6 0.1 0.00017 21.8 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA26504.1 - 0.0018 18.7 0.1 0.004 17.5 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GMC_oxred_N PF00732.19 EEA26506.1 - 4e-47 161.0 0.9 6.3e-47 160.4 0.9 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA26506.1 - 1.6e-28 100.0 0.9 3.1e-28 99.1 0.1 1.9 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EEA26506.1 - 4.9e-07 29.2 0.7 3.4e-06 26.4 0.3 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA26506.1 - 3.3e-06 26.5 1.1 1.2e-05 24.7 0.4 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA26506.1 - 2.3e-05 23.8 0.1 4.5e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA26506.1 - 9e-05 22.6 1.1 0.00036 20.7 0.5 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA26506.1 - 0.00071 18.9 0.2 0.0016 17.8 0.2 1.5 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 EEA26506.1 - 0.0026 17.2 2.7 0.0061 15.9 2.7 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA26506.1 - 0.0066 15.2 1.8 0.014 14.1 0.5 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EEA26506.1 - 0.0092 16.5 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA26506.1 - 0.0095 15.2 0.0 3.4 6.8 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA26506.1 - 0.015 14.9 6.0 0.13 11.8 5.9 2.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EEA26506.1 - 0.02 14.0 1.4 0.1 11.7 1.0 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF5578 PF17741.1 EEA26506.1 - 0.052 13.0 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5578) 3HCDH_N PF02737.18 EEA26506.1 - 0.16 11.8 1.6 1.3 8.8 0.3 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AMP-binding PF00501.28 EEA26507.1 - 3.2e-24 85.3 0.0 4e-22 78.4 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme DEAD PF00270.29 EEA26508.1 - 1.5e-36 125.8 0.0 2.1e-18 66.7 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA26508.1 - 5.6e-18 65.3 0.0 3e-17 62.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA26508.1 - 1.4e-09 38.2 2.2 2.7e-09 37.2 0.0 2.5 2 2 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EEA26508.1 - 0.0011 19.4 0.0 0.0036 17.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EEA26508.1 - 0.047 14.0 0.0 8.7 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain PIGA PF08288.12 EEA26509.1 - 3.2e-45 152.6 2.5 3.5e-45 152.5 1.0 1.8 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EEA26509.1 - 9.1e-29 100.6 0.2 1.5e-28 99.9 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EEA26509.1 - 1.5e-27 96.2 0.0 2.3e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA26509.1 - 3.7e-24 85.7 0.1 6.7e-24 84.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EEA26509.1 - 3.3e-11 43.9 0.0 5.9e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EEA26509.1 - 3.4e-06 27.1 0.1 7.6e-06 26.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EEA26509.1 - 0.00037 20.8 0.0 0.00094 19.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Arf PF00025.21 EEA26511.1 - 9.6e-40 135.9 0.1 1.2e-26 93.2 0.1 2.3 2 1 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 EEA26511.1 - 1.1e-14 54.4 0.0 7.8e-09 35.1 0.0 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EEA26511.1 - 1.3e-11 44.7 0.0 3.3e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EEA26511.1 - 1.9e-09 37.2 0.0 2.4e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 EEA26511.1 - 1.9e-08 34.1 0.0 3.6e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 Ras family SRPRB PF09439.10 EEA26511.1 - 4.7e-06 26.2 0.0 2.5e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EEA26511.1 - 1.6e-05 25.0 0.0 2.5e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA26511.1 - 0.00097 18.7 1.2 0.011 15.3 1.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 EEA26511.1 - 0.16 11.8 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 EEA26511.1 - 0.19 11.1 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Sugar_tr PF00083.24 EEA26513.1 - 4.2e-81 273.1 24.8 4.9e-81 272.9 24.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA26513.1 - 1.4e-15 57.1 32.0 1.4e-15 57.1 32.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA26513.1 - 2.2e-08 33.1 23.4 7.7e-06 24.7 3.6 3.0 2 1 1 3 3 3 2 MFS/sugar transport protein Glyco_hydro_31 PF01055.26 EEA26514.1 - 3.3e-103 346.3 3.8 4.6e-103 345.8 3.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF4968 PF16338.5 EEA26514.1 - 0.053 13.8 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4968) Zn_clus PF00172.18 EEA26515.1 - 5.1e-09 36.1 7.4 5.1e-09 36.1 7.4 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA26515.1 - 0.00012 21.2 3.1 0.00015 20.9 1.6 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF1386 PF07138.11 EEA26515.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1386) Glyco_hydro_71 PF03659.14 EEA26516.1 - 2.8e-92 309.5 2.1 3.2e-92 309.2 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Prp18 PF02840.15 EEA26517.1 - 5.8e-56 188.5 0.0 5.8e-56 188.5 0.0 2.3 2 1 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EEA26517.1 - 1.8e-13 49.8 0.4 1.8e-13 49.8 0.4 2.7 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like DDHD PF02862.17 EEA26517.1 - 0.29 11.3 1.8 0.4 10.8 1.8 1.4 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.19 EEA26517.1 - 1.8 6.4 5.6 2.4 6.0 5.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SOBP PF15279.6 EEA26517.1 - 8.5 6.9 7.0 15 6.1 7.0 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein SAP18 PF06487.12 EEA26518.1 - 2e-48 164.2 0.0 3.9e-48 163.2 0.0 1.5 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) GST_N PF02798.20 EEA26519.1 - 2.4e-05 24.6 0.0 6.1e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA26519.1 - 3.3e-05 24.2 0.0 0.00018 21.8 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA26519.1 - 0.0011 19.2 0.0 0.0026 17.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA26519.1 - 0.084 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 EEA26519.1 - 0.095 13.5 0.0 0.59 10.9 0.0 2.3 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 EEA26519.1 - 0.1 12.6 0.0 0.29 11.2 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain BTB_2 PF02214.22 EEA26520.1 - 2e-05 24.8 0.1 0.0008 19.7 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain BTB PF00651.31 EEA26520.1 - 0.092 13.0 0.0 35 4.7 0.0 2.9 2 1 1 3 3 3 0 BTB/POZ domain Sugar_tr PF00083.24 EEA26521.1 - 5.9e-97 325.4 28.5 7e-97 325.1 28.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA26521.1 - 2.3e-19 69.5 39.2 2.3e-19 69.5 39.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GFO_IDH_MocA PF01408.22 EEA26522.1 - 2.8e-19 70.1 0.0 7.7e-19 68.7 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EEA26522.1 - 0.0068 16.8 0.0 0.02 15.3 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain ox_reductase_C PF08635.10 EEA26522.1 - 0.1 12.3 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain UbiA PF01040.18 EEA26523.1 - 1e-24 87.3 5.6 1e-24 87.3 5.6 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Sulfatase PF00884.23 EEA26524.1 - 1.6e-52 178.8 0.0 1.9e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EEA26524.1 - 0.081 12.5 0.0 2 7.9 0.0 2.2 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase Usp PF00582.26 EEA26526.1 - 8.5e-21 74.9 3.2 2e-13 51.1 0.3 3.5 3 0 0 3 3 3 2 Universal stress protein family ATP-synt_ab PF00006.25 EEA26527.1 - 1.8e-68 230.4 0.0 2.8e-68 229.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EEA26527.1 - 1.5e-13 51.0 0.2 3e-13 50.1 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab PF00006.25 EEA26528.1 - 1.3e-68 230.9 0.0 1.8e-68 230.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EEA26528.1 - 1.1e-13 51.4 0.2 2.3e-13 50.5 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain WD40 PF00400.32 EEA26529.1 - 2.2e-45 151.7 21.7 9e-08 32.7 0.8 8.1 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26529.1 - 5.7e-14 52.2 2.4 2.6e-06 27.6 0.1 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EEA26529.1 - 8.8e-05 21.4 1.0 1.5 7.5 0.0 3.2 2 1 1 3 3 3 3 Nup133 N terminal like Nup160 PF11715.8 EEA26529.1 - 0.00036 19.3 2.4 0.035 12.8 0.1 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 MerR PF00376.23 EEA26529.1 - 0.036 13.8 0.0 0.72 9.7 0.0 2.8 3 0 0 3 3 3 0 MerR family regulatory protein Trp_syntA PF00290.20 EEA26530.1 - 3.8e-92 307.8 0.0 7e-92 306.9 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 EEA26530.1 - 3.6e-49 167.7 1.6 5.5e-49 167.1 1.6 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peripla_BP_6 PF13458.6 EEA26530.1 - 0.0032 17.2 0.0 0.03 14.0 0.0 2.4 2 0 0 2 2 2 1 Periplasmic binding protein ADH_zinc_N PF00107.26 EEA26532.1 - 5.5e-22 78.1 0.4 8.6e-22 77.5 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA26532.1 - 4.6e-07 31.0 0.0 9.5e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA26532.1 - 6.9e-06 25.9 0.0 2.3e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EEA26532.1 - 0.024 13.9 0.7 0.04 13.2 0.7 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EEA26532.1 - 0.15 11.5 0.5 0.3 10.5 0.5 1.4 1 0 0 1 1 1 0 short chain dehydrogenase RVT_2 PF07727.14 EEA26533.1 - 4.2e-38 131.3 0.2 7.5e-38 130.5 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA26533.1 - 2.5e-07 30.5 0.0 5.8e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA26533.1 - 0.00069 19.8 0.0 0.0016 18.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA26533.1 - 0.03 13.8 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA26533.1 - 0.092 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA26533.1 - 0.14 12.5 3.2 0.37 11.1 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein Fungal_trans_2 PF11951.8 EEA26534.1 - 0.0009 18.2 0.7 0.019 13.8 0.1 2.2 1 1 1 2 2 2 2 Fungal specific transcription factor domain DUF829 PF05705.14 EEA26535.1 - 4.9e-42 144.5 0.0 6.2e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) p450 PF00067.22 EEA26536.1 - 3.1e-56 191.0 0.1 4.1e-56 190.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 HTH_Tnp_Tc3_2 PF01498.18 EEA26537.1 - 1.4e-09 38.1 2.0 1.4e-09 38.1 2.0 2.6 3 0 0 3 3 3 1 Transposase DDE_3 PF13358.6 EEA26537.1 - 5.4e-09 36.0 0.0 1.7e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 EEA26537.1 - 5.9e-06 26.8 4.9 0.00013 22.5 0.2 3.5 1 1 2 3 3 3 2 Homeodomain-like domain HTH_WhiA PF02650.14 EEA26537.1 - 0.02 15.2 1.7 0.04 14.3 1.7 1.4 1 0 0 1 1 1 0 WhiA C-terminal HTH domain DUF2045 PF09741.9 EEA26537.1 - 0.044 13.2 0.0 0.068 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2045) CPSase_L_D2 PF02786.17 EEA26537.1 - 0.15 11.6 0.1 0.24 10.9 0.1 1.2 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain RVT_2 PF07727.14 EEA26538.1 - 2.8e-40 138.5 0.0 4.9e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA26538.1 - 4.5e-08 32.8 0.1 1.4e-07 31.2 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA26538.1 - 5.9e-07 29.7 0.1 1.1e-05 25.6 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 EEA26538.1 - 0.00017 21.3 0.8 0.12 12.2 0.0 3.3 2 0 0 2 2 2 2 Integrase core domain AA_permease_2 PF13520.6 EEA26539.1 - 6.2e-65 219.7 46.6 7.5e-65 219.4 46.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA26539.1 - 4.7e-13 48.6 38.7 7.5e-13 47.9 38.7 1.3 1 1 0 1 1 1 1 Amino acid permease Acetyltransf_13 PF13880.6 EEA26539.1 - 0.034 14.1 0.0 1 9.4 0.0 2.8 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase DnaJ PF00226.31 EEA26540.1 - 4.5e-22 78.0 5.2 4.5e-22 78.0 5.2 2.7 3 1 0 3 3 3 1 DnaJ domain zf-C4H2 PF10146.9 EEA26540.1 - 6.5 7.0 16.4 2.1 8.6 13.1 1.8 2 1 0 2 2 2 0 Zinc finger-containing protein Presenilin PF01080.17 EEA26540.1 - 8.7 5.0 6.7 15 4.2 6.7 1.4 1 0 0 1 1 1 0 Presenilin Pyr_redox_2 PF07992.14 EEA26541.1 - 9.9e-40 136.6 0.0 1.2e-39 136.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA26541.1 - 2e-16 60.3 0.0 1e-11 45.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA26541.1 - 3e-09 36.5 0.0 2.2e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) TrkA_N PF02254.18 EEA26541.1 - 7.3e-05 23.0 0.0 0.035 14.4 0.0 2.4 2 0 0 2 2 2 2 TrkA-N domain Pyr_redox_3 PF13738.6 EEA26541.1 - 0.00083 18.7 0.0 0.0051 16.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA26541.1 - 0.0016 18.1 0.2 3 7.4 0.0 3.2 4 0 0 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA26541.1 - 0.0052 17.0 0.0 2.6 8.4 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EEA26541.1 - 0.023 14.7 0.1 9.7 6.2 0.0 3.0 3 0 0 3 3 3 0 FAD-NAD(P)-binding Herpes_UL49_1 PF03117.14 EEA26541.1 - 0.18 11.1 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 UL49 family Inv-AAD PF18785.1 EEA26542.1 - 9.8e-43 145.1 0.0 1.4e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EEA26542.1 - 5.4e-11 42.3 0.0 4.6e-10 39.3 0.0 2.3 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 EEA26542.1 - 7e-05 22.8 0.0 8.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain Stn1 PF10451.9 EEA26543.1 - 1.9e-13 50.0 0.4 2.2e-08 33.4 0.0 2.2 2 0 0 2 2 2 2 Telomere regulation protein Stn1 Stc1 PF12898.7 EEA26545.1 - 3.5e-18 65.9 9.1 7.7e-18 64.8 9.1 1.6 1 0 0 1 1 1 1 Stc1 domain Pkinase PF00069.25 EEA26546.1 - 6.4e-59 199.5 0.0 9.3e-59 198.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26546.1 - 2e-33 115.8 0.0 5.8e-32 111.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA26546.1 - 0.0022 17.0 0.0 0.0035 16.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EEA26546.1 - 0.014 14.4 0.0 0.019 13.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RNase_PH PF01138.21 EEA26547.1 - 6e-10 39.7 0.0 1.8e-08 35.0 0.0 2.4 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 SVIP PF15811.5 EEA26548.1 - 1.4 9.5 4.5 0.25 11.8 0.7 1.7 2 0 0 2 2 2 0 Small VCP/p97-interacting protein Cytochrom_C PF00034.21 EEA26549.1 - 8.8e-12 46.0 0.0 1.1e-11 45.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EEA26549.1 - 1.1e-08 35.2 1.5 5.8e-08 32.9 1.5 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EEA26549.1 - 0.00028 20.6 0.6 0.00079 19.1 0.5 1.9 1 1 0 1 1 1 1 Cytochrome c-550 domain Cytochrom_C PF00034.21 EEA26550.1 - 2e-09 38.4 0.0 2.3e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EEA26550.1 - 2.8e-07 30.8 1.5 1.4e-06 28.5 1.5 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EEA26550.1 - 0.00028 20.6 0.6 0.00077 19.2 0.6 1.9 1 1 0 1 1 1 1 Cytochrome c-550 domain Baculo_PEP_C PF04513.12 EEA26551.1 - 0.00037 20.5 6.1 0.013 15.6 0.3 3.3 3 0 0 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus I_LWEQ PF01608.17 EEA26551.1 - 0.16 12.2 0.4 0.3 11.3 0.4 1.4 1 0 0 1 1 1 0 I/LWEQ domain RNA_pol_A_bac PF01000.26 EEA26552.1 - 1.4e-28 99.5 0.0 2e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EEA26552.1 - 3.8e-17 61.5 0.0 5e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PriA_CRR PF18319.1 EEA26552.1 - 0.046 13.7 1.8 0.046 13.7 1.8 1.7 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain RNA_pol_A_bac PF01000.26 EEA26553.1 - 1.4e-28 99.5 0.0 2.3e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EEA26553.1 - 4.3e-17 61.3 0.0 5.8e-17 60.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PriA_CRR PF18319.1 EEA26553.1 - 0.049 13.6 1.8 0.049 13.6 1.8 1.7 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain Fungal_trans_2 PF11951.8 EEA26554.1 - 3.8e-39 134.6 0.1 3.8e-39 134.6 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26554.1 - 9.1e-08 32.1 5.9 1.8e-07 31.2 5.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CPSF100_C PF13299.6 EEA26554.1 - 0.12 12.6 0.2 0.2 11.9 0.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal GST_N PF02798.20 EEA26555.1 - 6.6e-14 52.0 0.0 1.1e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA26555.1 - 1.2e-11 44.8 0.0 2.2e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA26555.1 - 7e-10 39.0 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA26555.1 - 1.5e-08 34.8 0.0 2.6e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA26555.1 - 2.6e-06 27.3 0.0 4.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA26555.1 - 6.1e-05 23.1 0.0 9.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF3425 PF11905.8 EEA26556.1 - 2.4e-13 50.1 0.0 6.9e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) NUDIX PF00293.28 EEA26557.1 - 5.8e-18 65.2 0.2 6.9e-18 64.9 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain ATE_C PF04377.15 EEA26558.1 - 3.2e-47 160.5 1.4 6.9e-47 159.4 1.4 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EEA26558.1 - 9.1e-22 77.3 5.6 2.3e-21 76.0 5.6 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 EEA26558.1 - 0.015 15.5 0.5 0.032 14.4 0.5 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-Dof PF02701.15 EEA26558.1 - 0.093 12.9 1.4 0.17 12.1 0.7 1.8 2 0 0 2 2 2 0 Dof domain, zinc finger Calcipressin PF04847.12 EEA26559.1 - 2.1e-33 115.7 0.1 3.6e-33 114.9 0.1 1.4 1 0 0 1 1 1 1 Calcipressin AMP-binding PF00501.28 EEA26560.1 - 1.5e-79 267.6 0.0 1.9e-79 267.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA26560.1 - 3.2e-11 44.1 0.0 1.3e-10 42.1 0.0 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CFEM PF05730.11 EEA26561.1 - 2e-13 50.2 13.8 3.3e-13 49.5 13.8 1.4 1 0 0 1 1 1 1 CFEM domain Uds1 PF15456.6 EEA26562.1 - 2e-25 89.5 11.6 2e-25 89.5 11.6 2.5 3 0 0 3 3 3 1 Up-regulated During Septation Seryl_tRNA_N PF02403.22 EEA26562.1 - 0.19 12.0 6.4 0.76 10.0 6.4 2.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Prominin PF05478.11 EEA26562.1 - 1.1 7.2 4.1 0.52 8.2 1.7 1.5 1 1 1 2 2 2 0 Prominin Tropomyosin_1 PF12718.7 EEA26562.1 - 2.4 8.3 10.9 0.42 10.8 6.9 1.8 2 0 0 2 2 2 0 Tropomyosin like DUF4407 PF14362.6 EEA26562.1 - 3.5 6.9 9.3 0.32 10.3 5.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) BLOC1_2 PF10046.9 EEA26562.1 - 5.7 7.3 6.6 3.3 8.1 0.9 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 EEA26562.1 - 6.3 7.3 10.3 1.2 9.7 4.8 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region GrpE PF01025.19 EEA26563.1 - 1.6e-42 145.0 3.9 2.2e-42 144.6 3.8 1.2 1 0 0 1 1 1 1 GrpE DUF4201 PF13870.6 EEA26563.1 - 0.014 15.1 0.1 0.026 14.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) tRNA-synt_2d PF01409.20 EEA26564.1 - 6.3e-50 169.9 0.5 1e-26 93.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EEA26564.1 - 3.4e-28 97.9 0.0 9.3e-28 96.5 0.0 1.8 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Mito_carr PF00153.27 EEA26565.1 - 2.8e-61 203.5 0.1 2.8e-20 72.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein TauE PF01925.19 EEA26565.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE PDZ_1 PF12812.7 EEA26566.1 - 1.1e-30 105.5 0.9 8.7e-23 80.1 0.0 4.2 4 0 0 4 4 4 2 PDZ-like domain Trypsin_2 PF13365.6 EEA26566.1 - 3.5e-21 76.7 0.0 3e-19 70.4 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 EEA26566.1 - 1.7e-14 53.9 0.5 0.00017 21.9 0.0 3.9 4 0 0 4 4 4 3 PDZ domain PDZ_6 PF17820.1 EEA26566.1 - 9.4e-13 47.8 0.8 6.5e-05 22.7 0.0 4.1 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 EEA26566.1 - 4e-06 27.1 0.1 0.12 12.8 0.0 3.3 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 EEA26566.1 - 0.0013 18.6 0.3 1.7 8.7 0.0 3.5 4 0 0 4 4 4 2 Tricorn protease PDZ domain Trypsin PF00089.26 EEA26566.1 - 0.0035 17.2 0.0 0.0095 15.8 0.0 1.6 1 0 0 1 1 1 1 Trypsin PDZ_1 PF12812.7 EEA26567.1 - 1e-24 86.3 0.6 7.7e-23 80.3 0.0 3.9 4 0 0 4 4 4 1 PDZ-like domain Trypsin_2 PF13365.6 EEA26567.1 - 2.9e-21 76.9 0.0 2.6e-19 70.6 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 EEA26567.1 - 9.9e-11 41.3 1.3 5.8e-05 22.9 0.0 3.1 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 EEA26567.1 - 8.6e-10 38.8 0.6 0.00015 22.0 0.0 3.0 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 EEA26567.1 - 3.6e-06 27.2 0.1 0.11 12.9 0.0 3.2 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 EEA26567.1 - 0.0013 18.7 0.2 1.5 8.8 0.0 3.3 3 0 0 3 3 3 2 Tricorn protease PDZ domain Trypsin PF00089.26 EEA26567.1 - 0.003 17.4 0.0 0.0082 16.0 0.0 1.7 1 0 0 1 1 1 1 Trypsin Glyco_hydro_16 PF00722.21 EEA26568.1 - 0.00035 20.1 0.0 0.00097 18.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 COX6B PF02297.17 EEA26569.1 - 5.3e-18 65.0 5.8 6.6e-18 64.7 5.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EEA26569.1 - 0.01 15.8 1.9 0.016 15.2 1.7 1.4 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 EEA26569.1 - 0.035 14.0 1.0 0.057 13.4 0.9 1.4 1 1 0 1 1 1 0 APOBEC-like C-terminal domain T2SSJ PF11612.8 EEA26569.1 - 0.057 13.6 0.2 0.86 9.8 0.2 2.0 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein J B12D PF06522.11 EEA26570.1 - 0.00033 20.4 0.0 0.00046 19.9 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit ThrE PF06738.12 EEA26570.1 - 0.11 11.9 0.0 0.13 11.6 0.0 1.0 1 0 0 1 1 1 0 Putative threonine/serine exporter DUF3398 PF11878.8 EEA26570.1 - 0.15 12.5 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) B12D PF06522.11 EEA26571.1 - 0.00016 21.4 0.0 0.0002 21.1 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit RRM_1 PF00076.22 EEA26572.1 - 4.8e-17 61.5 0.0 7.6e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA26572.1 - 0.0026 17.8 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EEA26572.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 EEA26573.1 - 4.7e-17 61.6 0.0 7.5e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA26573.1 - 0.0026 17.9 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EEA26573.1 - 0.013 15.4 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SRA1 PF07304.11 EEA26574.1 - 3.2e-11 43.2 0.0 3.2e-11 43.2 0.0 4.3 6 0 0 6 6 6 1 Steroid receptor RNA activator (SRA1) WD40 PF00400.32 EEA26574.1 - 1.3e-09 38.4 4.6 1.3 10.0 0.0 6.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA26574.1 - 0.00018 21.8 0.1 0.0024 18.1 0.0 2.9 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Prp18 PF02840.15 EEA26574.1 - 0.021 14.9 0.0 0.05 13.6 0.0 1.6 1 0 0 1 1 1 0 Prp18 domain dsrm PF00035.26 EEA26574.1 - 0.059 14.1 0.0 0.2 12.4 0.0 1.9 1 0 0 1 1 1 0 Double-stranded RNA binding motif Sec16_C PF12931.7 EEA26574.1 - 0.08 12.6 0.0 0.45 10.1 0.0 2.1 1 1 0 1 1 1 0 Sec23-binding domain of Sec16 Pex14_N PF04695.13 EEA26575.1 - 2.3e-39 135.6 0.3 2.3e-39 135.6 0.3 2.2 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3035 PF11233.8 EEA26575.1 - 0.17 12.2 4.6 0.13 12.5 2.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3035) PAPA-1 PF04795.12 EEA26576.1 - 6.9e-30 103.7 1.3 6.9e-30 103.7 1.3 3.1 2 1 1 3 3 3 1 PAPA-1-like conserved region Amidohydro_2 PF04909.14 EEA26577.1 - 3.7e-34 118.8 0.4 4.7e-34 118.5 0.4 1.1 1 0 0 1 1 1 1 Amidohydrolase Fungal_trans PF04082.18 EEA26578.1 - 2.8e-10 39.7 0.0 4.7e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26578.1 - 2.7e-06 27.4 10.9 5.4e-06 26.4 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA26579.1 - 2.8e-10 39.7 0.0 4.7e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26579.1 - 2.7e-06 27.4 10.9 5.4e-06 26.4 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EEA26580.1 - 8.4e-20 71.3 0.1 2.3e-19 69.9 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA26580.1 - 6.7e-08 32.7 0.8 1.5e-07 31.5 0.8 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA26580.1 - 5.4e-06 25.9 0.3 1.3e-05 24.6 0.3 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA26580.1 - 7.5e-05 22.3 1.0 0.00012 21.6 1.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EEA26580.1 - 0.00029 20.5 8.0 0.00098 18.8 6.1 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA26580.1 - 0.0061 15.7 5.8 0.007 15.5 4.7 1.7 1 1 1 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EEA26580.1 - 0.038 14.6 0.6 0.038 14.6 0.6 2.2 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA26580.1 - 0.081 11.6 2.1 0.13 10.9 2.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Amino_oxidase PF01593.24 EEA26580.1 - 0.16 11.2 0.4 0.32 10.2 0.2 1.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EEA26580.1 - 0.2 10.9 4.1 0.072 12.3 1.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA26580.1 - 0.23 10.5 2.4 0.45 9.5 2.4 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A Mus7 PF09462.10 EEA26581.1 - 3.9e-180 600.7 0.0 6e-180 600.1 0.0 1.3 1 0 0 1 1 1 1 Mus7/MMS22 family An_peroxidase PF03098.15 EEA26582.1 - 5.4e-40 137.5 0.2 3.1e-26 92.0 0.1 3.1 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EEA26582.1 - 8.6e-08 31.3 0.0 2.9e-06 26.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 DUF2235 PF09994.9 EEA26583.1 - 6.7e-100 334.1 0.1 8.6e-100 333.8 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF896 PF05979.12 EEA26583.1 - 0.015 15.1 0.1 0.057 13.3 0.1 2.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) FAD_binding_2 PF00890.24 EEA26585.1 - 7.3e-94 315.2 0.0 8.3e-94 315.0 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EEA26585.1 - 1.4e-08 34.4 0.2 3.1e-08 33.3 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA26585.1 - 2.5e-07 30.8 1.5 5.9e-07 29.6 0.4 2.3 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EEA26585.1 - 1.2e-06 28.2 0.0 1.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EEA26585.1 - 7.9e-06 25.7 3.2 3.7e-05 23.5 2.8 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EEA26585.1 - 1.5e-05 24.3 0.3 1.5e-05 24.3 0.3 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EEA26585.1 - 2.9e-05 23.5 2.0 0.00011 21.6 0.2 2.7 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA26585.1 - 0.00061 18.6 0.8 0.0013 17.5 0.1 1.9 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EEA26585.1 - 0.00082 18.7 0.3 0.0018 17.6 0.3 1.5 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EEA26585.1 - 0.0025 16.9 0.4 0.0039 16.3 0.4 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 EEA26585.1 - 0.003 18.1 1.7 0.019 15.5 0.5 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA26585.1 - 0.012 14.9 0.1 0.026 13.8 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EEA26585.1 - 0.036 13.4 0.1 0.079 12.2 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EEA26585.1 - 0.074 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EEA26586.1 - 1.1e-47 163.4 1.6 3.2e-46 158.6 1.6 2.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EEA26586.1 - 5.1e-17 61.9 0.4 1.3e-16 60.6 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA26586.1 - 4e-06 26.3 0.1 1.4e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA26586.1 - 1.1e-05 25.9 0.2 2.2e-05 24.9 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA26586.1 - 0.00011 21.5 0.5 0.00017 20.9 0.5 1.2 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EEA26586.1 - 0.00021 20.1 0.6 0.00021 20.1 0.6 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EEA26586.1 - 0.00026 20.5 0.3 0.00037 20.0 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA26586.1 - 0.00027 20.3 0.0 0.00049 19.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EEA26586.1 - 0.00051 19.7 3.6 0.0013 18.3 3.6 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EEA26586.1 - 0.0023 17.9 0.1 0.51 10.3 0.0 2.8 3 0 0 3 3 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EEA26586.1 - 0.0029 16.9 0.3 0.0044 16.3 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EEA26586.1 - 0.0034 16.5 2.1 0.0053 15.9 2.1 1.2 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.18 EEA26586.1 - 0.016 15.1 0.4 0.028 14.3 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EEA26586.1 - 0.12 11.4 1.3 0.24 10.4 1.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 EEA26586.1 - 0.19 11.1 0.1 0.33 10.3 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 EEA26586.1 - 0.33 10.1 3.4 0.29 10.3 1.7 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Homeodomain PF00046.29 EEA26588.1 - 1e-14 54.1 3.8 1.9e-14 53.2 1.7 2.3 2 0 0 2 2 2 1 Homeodomain NmrA PF05368.13 EEA26589.1 - 2.8e-11 43.5 0.0 1.4e-10 41.2 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA26589.1 - 1.5e-09 38.0 0.0 3.2e-08 33.7 0.0 2.2 1 1 0 1 1 1 1 NAD(P)H-binding Myc_target_1 PF15179.6 EEA26590.1 - 0.061 13.2 1.1 0.064 13.2 0.6 1.4 1 1 0 1 1 1 0 Myc target protein 1 Mid2 PF04478.12 EEA26590.1 - 0.11 12.4 0.1 0.15 11.9 0.1 1.4 1 1 0 1 1 1 0 Mid2 like cell wall stress sensor Fungal_trans PF04082.18 EEA26591.1 - 3.5e-07 29.5 0.0 1.2e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Glyco_hydro_18 PF00704.28 EEA26592.1 - 4.7e-64 217.1 0.1 6.1e-64 216.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 30K_MP_C_Ter PF11330.8 EEA26593.1 - 0.068 12.5 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins DUF2236 PF09995.9 EEA26594.1 - 2.3e-31 109.8 0.0 3.1e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) AMP-binding PF00501.28 EEA26595.1 - 3.1e-09 35.9 0.0 3.7e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme FAD_binding_3 PF01494.19 EEA26596.1 - 6.9e-16 58.4 0.0 2.7e-15 56.5 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EEA26596.1 - 0.0029 16.7 0.0 0.0045 16.1 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Lipase_3 PF01764.25 EEA26597.1 - 1e-35 122.7 0.0 1.5e-35 122.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Lipase3_N PF03893.16 EEA26597.1 - 1.6e-12 47.3 0.2 3.2e-12 46.3 0.2 1.5 1 0 0 1 1 1 1 Lipase 3 N-terminal region Hydrolase_4 PF12146.8 EEA26597.1 - 0.0013 18.1 0.0 0.0023 17.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 EEA26597.1 - 0.0021 17.7 0.1 0.14 11.7 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 EEA26597.1 - 0.016 15.8 0.1 0.023 15.3 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EEA26597.1 - 0.019 15.1 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_5 PF12695.7 EEA26597.1 - 0.047 13.5 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Metallophos PF00149.28 EEA26598.1 - 2.4e-13 51.1 0.0 3.8e-13 50.4 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA26598.1 - 3.3e-06 27.4 0.0 0.00022 21.5 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain p450 PF00067.22 EEA26599.1 - 4.8e-29 101.4 0.0 3.3e-28 98.6 0.0 1.9 2 0 0 2 2 2 1 Cytochrome P450 BAH PF01426.18 EEA26599.1 - 0.058 13.2 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 BAH domain Peptidase_M19 PF01244.21 EEA26600.1 - 9.9e-71 238.5 0.0 1.2e-70 238.2 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Fungal_trans PF04082.18 EEA26601.1 - 1.6e-20 73.3 0.0 2.8e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26601.1 - 0.00012 22.1 7.5 0.0002 21.4 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4718 PF15842.5 EEA26601.1 - 0.013 15.3 0.1 0.036 13.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) MFS_1 PF07690.16 EEA26602.1 - 7.3e-28 97.5 34.8 7.3e-26 90.9 30.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FtsH_ext PF06480.15 EEA26602.1 - 0.087 13.2 0.5 0.64 10.4 0.3 2.4 1 1 1 2 2 2 0 FtsH Extracellular GST_N_2 PF13409.6 EEA26603.1 - 7.6e-09 35.8 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA26603.1 - 1.7e-08 34.8 0.0 3.2e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA26603.1 - 0.0017 18.3 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA26603.1 - 0.0043 17.2 0.0 0.0084 16.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA26603.1 - 0.085 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MFS_1 PF07690.16 EEA26604.1 - 2.5e-26 92.4 54.3 1.1e-25 90.4 38.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RVT_2 PF07727.14 EEA26605.1 - 5.8e-61 206.2 0.0 9.1e-61 205.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA26605.1 - 5.1e-16 58.9 0.0 2.1e-15 56.9 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain DUF4219 PF13961.6 EEA26605.1 - 2e-10 40.1 0.1 2e-10 40.1 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4219) gag_pre-integrs PF13976.6 EEA26605.1 - 1.4e-09 37.7 0.3 5.7e-09 35.7 0.1 2.2 2 0 0 2 2 2 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EEA26605.1 - 2.7e-08 33.6 1.1 5.5e-08 32.6 1.1 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 EEA26605.1 - 4.4e-06 26.5 1.7 1e-05 25.3 1.7 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 EEA26605.1 - 0.061 13.2 1.3 0.15 12.0 1.3 1.6 1 0 0 1 1 1 0 Zinc knuckle rve_3 PF13683.6 EEA26605.1 - 0.069 12.9 0.2 0.43 10.4 0.0 2.5 3 0 0 3 3 3 0 Integrase core domain CAF1A PF12253.8 EEA26605.1 - 0.079 13.1 1.0 0.24 11.6 0.4 2.1 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A RVT_1 PF00078.27 EEA26605.1 - 0.11 12.0 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_2 PF13696.6 EEA26605.1 - 0.38 10.6 1.2 0.78 9.6 1.2 1.5 1 0 0 1 1 1 0 Zinc knuckle Ank_2 PF12796.7 EEA26606.1 - 4.9e-262 847.4 74.0 1.1e-17 64.4 0.0 20.6 2 2 21 23 23 23 23 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA26606.1 - 8.2e-212 658.7 17.8 2.2e-05 24.5 0.0 38.8 39 0 0 39 39 39 37 Ankyrin repeat Ank_4 PF13637.6 EEA26606.1 - 8.9e-205 660.7 44.8 4.7e-10 39.8 0.0 31.7 5 4 28 34 34 34 34 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA26606.1 - 4.3e-187 603.7 40.1 6.4e-10 39.1 0.0 29.3 9 6 19 30 30 30 30 Ankyrin repeats (many copies) Ank PF00023.30 EEA26606.1 - 5.4e-177 567.4 50.3 1.1e-06 28.8 0.1 38.1 38 0 0 38 38 38 35 Ankyrin repeat UDPG_MGDP_dh_C PF03720.15 EEA26606.1 - 1e-12 48.4 4.6 15 6.1 0.0 16.0 12 4 8 20 20 18 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain DUF3944 PF13099.6 EEA26606.1 - 1.9e-07 30.8 0.2 43 4.1 0.0 7.2 6 0 0 6 6 6 0 Domain of unknown function (DUF3944) DUF1018 PF06252.12 EEA26606.1 - 4e-06 27.8 7.5 9.6 7.2 0.1 8.1 6 2 4 10 10 9 1 Protein of unknown function (DUF1018) Herpeto_peptide PF14409.6 EEA26606.1 - 5.7e-05 23.3 4.3 74 3.7 0.0 6.7 2 1 3 6 6 6 0 Ribosomally synthesized peptide in Herpetosiphon YlzJ PF14035.6 EEA26606.1 - 0.00054 20.1 0.0 57 4.0 0.0 6.7 3 3 4 7 7 7 0 YlzJ-like protein DBD_Tnp_Hermes PF10683.9 EEA26606.1 - 0.0023 17.6 2.5 56 3.5 0.0 7.8 10 0 0 10 10 8 0 Hermes transposase DNA-binding domain AbiEi_3_N PF17194.4 EEA26606.1 - 0.021 14.8 12.2 18 5.5 0.1 8.0 7 3 2 11 11 11 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain CppA_C PF14507.6 EEA26606.1 - 0.033 14.9 3.9 94 3.8 0.0 6.2 3 2 5 8 8 8 0 CppA C-terminal DUF3116 PF11313.8 EEA26606.1 - 0.08 12.8 0.0 3 7.8 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3116) PHB_acc_N PF07879.11 EEA26606.1 - 0.43 10.7 20.2 1e+02 3.1 0.1 11.0 11 3 3 14 14 13 0 PHB/PHA accumulation regulator DNA-binding domain V-SNARE PF05008.15 EEA26606.1 - 1 9.8 10.3 49 4.4 0.1 5.2 1 1 4 5 5 5 0 Vesicle transport v-SNARE protein N-terminus zf-GRF PF06839.12 EEA26608.1 - 2.4 8.3 10.5 0.026 14.6 2.2 2.1 2 0 0 2 2 2 0 GRF zinc finger RVT_2 PF07727.14 EEA26609.1 - 4.2e-38 131.3 0.2 7.5e-38 130.5 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA26609.1 - 2.5e-07 30.5 0.0 5.8e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA26609.1 - 0.00069 19.8 0.0 0.0016 18.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA26609.1 - 0.03 13.8 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA26609.1 - 0.092 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA26609.1 - 0.14 12.5 3.2 0.37 11.1 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein DUF3974 PF13120.6 EEA26610.1 - 0.004 17.2 0.2 0.037 14.1 0.2 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3974) OrsD PF12013.8 EEA26611.1 - 1.1e-19 71.0 0.0 3e-19 69.5 0.0 1.8 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D Helicase_C PF00271.31 EEA26612.1 - 8.7e-12 45.4 0.0 9.9e-11 42.0 0.0 2.6 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA26612.1 - 4.5e-11 42.8 0.0 1.6e-10 41.0 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 EEA26612.1 - 3.4e-05 24.3 6.0 4.3e-05 23.9 3.3 2.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 EEA26612.1 - 0.00083 19.4 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EEA26612.1 - 0.016 15.9 0.1 0.057 14.1 0.1 2.0 1 0 0 1 1 1 0 RecQ zinc-binding Peptidase_S8 PF00082.22 EEA26612.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Subtilase family OrsD PF12013.8 EEA26613.1 - 3.6e-22 79.0 0.2 4.4e-21 75.5 0.2 2.7 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EEA26613.1 - 6e-14 52.2 0.1 1.3e-13 51.2 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA26613.1 - 5.3e-13 49.3 0.0 1.2e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA26613.1 - 3e-06 27.3 0.0 8.5e-06 25.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EEA26613.1 - 0.002 17.9 0.2 1.7 8.3 0.1 3.1 3 0 0 3 3 3 2 AAA domain OrsD PF12013.8 EEA26614.1 - 3.7e-22 78.9 0.3 3.7e-22 78.9 0.3 2.4 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-CCHC PF00098.23 EEA26617.1 - 0.00012 22.0 3.1 0.00023 21.1 3.1 1.5 1 0 0 1 1 1 1 Zinc knuckle Retrotran_gag_2 PF14223.6 EEA26617.1 - 0.00086 19.0 1.3 0.0017 18.0 0.6 1.7 1 1 1 2 2 2 1 gag-polypeptide of LTR copia-type VP9 PF09625.10 EEA26617.1 - 0.062 13.5 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 VP9 protein zf-CCHC_3 PF13917.6 EEA26617.1 - 0.066 13.2 0.3 0.14 12.2 0.3 1.4 1 0 0 1 1 1 0 Zinc knuckle Asp PF00026.23 EEA26618.1 - 9e-52 176.4 0.7 1.1e-51 176.2 0.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA26618.1 - 0.0028 17.9 0.0 2.1 8.5 0.0 2.5 2 0 0 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA26618.1 - 0.052 14.2 0.0 0.38 11.4 0.0 2.4 2 1 0 2 2 2 0 Aspartyl protease Asp PF00026.23 EEA26619.1 - 5.1e-49 167.4 0.0 6e-49 167.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA26619.1 - 0.0079 16.5 0.0 0.66 10.2 0.1 2.7 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal CPT PF07931.12 EEA26620.1 - 0.055 13.3 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Integrase_H2C2 PF17921.1 EEA26621.1 - 9.2e-16 57.7 0.1 2.4e-15 56.4 0.1 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EEA26621.1 - 0.0046 17.1 0.0 0.0091 16.2 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Chromo PF00385.24 EEA26621.1 - 0.075 13.0 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain OrsD PF12013.8 EEA26622.1 - 2.3e-21 76.3 0.0 7.2e-21 74.8 0.0 1.9 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EEA26624.1 - 7.2e-05 23.2 0.0 0.00014 22.3 0.0 1.4 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D P2_Phage_GpR PF06891.11 EEA26624.1 - 0.14 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 P2 phage tail completion protein R (GpR) HsbA PF12296.8 EEA26625.1 - 2e-08 34.7 0.6 4.7e-08 33.5 0.3 1.7 1 1 1 2 2 2 1 Hydrophobic surface binding protein A PRANC PF09372.10 EEA26625.1 - 0.052 13.9 2.4 0.26 11.6 0.2 2.2 2 0 0 2 2 2 0 PRANC domain RVT_1 PF00078.27 EEA26627.1 - 3.3e-30 105.2 0.1 5.5e-30 104.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EEA26627.1 - 8.9e-29 99.5 0.0 1.7e-28 98.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EEA26627.1 - 3.6e-18 65.8 0.0 7.7e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EEA26627.1 - 1.8e-15 56.8 0.1 1.2e-14 54.2 0.0 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain Asp_protease_2 PF13650.6 EEA26627.1 - 0.002 18.7 0.0 0.0041 17.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease zf-H2C2 PF09337.10 EEA26627.1 - 0.008 16.4 0.0 0.022 15.0 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger zf-rbx1 PF12678.7 EEA26627.1 - 0.036 14.3 0.7 0.11 12.9 0.7 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Retrotrans_gag PF03732.17 EEA26628.1 - 8.2e-06 26.0 0.5 1.7e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC PF00098.23 EEA26628.1 - 1.2e-05 25.1 0.4 2e-05 24.5 0.4 1.3 1 0 0 1 1 1 1 Zinc knuckle TolA_bind_tri PF16331.5 EEA26628.1 - 0.021 14.9 1.6 0.23 11.6 0.2 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation V_ATPase_I PF01496.19 EEA26629.1 - 0.05 11.5 0.5 0.05 11.5 0.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 EEA26629.1 - 0.052 12.8 1.8 0.057 12.6 1.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein DivIC PF04977.15 EEA26629.1 - 0.061 13.1 4.0 0.06 13.1 2.4 1.8 2 0 0 2 2 2 0 Septum formation initiator CENP-H PF05837.12 EEA26629.1 - 0.08 13.4 5.5 0.11 12.9 5.4 1.3 1 1 0 1 1 1 0 Centromere protein H (CENP-H) PEP-utilisers_N PF05524.13 EEA26629.1 - 0.093 12.9 1.8 0.14 12.4 1.4 1.5 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF16 PF01519.16 EEA26629.1 - 0.12 12.9 3.0 0.18 12.3 3.0 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF16 Tweety PF04906.13 EEA26629.1 - 0.12 11.0 0.1 0.14 10.8 0.1 1.1 1 0 0 1 1 1 0 Tweety LcrG PF07216.12 EEA26629.1 - 0.24 11.3 3.0 0.3 11.0 1.2 2.0 2 0 0 2 2 2 0 LcrG protein JIP_LZII PF16471.5 EEA26629.1 - 0.36 11.0 6.4 4.6 7.5 0.2 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF1043 PF06295.12 EEA26629.1 - 0.61 10.1 4.3 0.55 10.3 3.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) APG6_N PF17675.1 EEA26629.1 - 4.9 7.7 11.3 3.4 8.2 9.6 1.6 1 1 1 2 2 2 0 Apg6 coiled-coil region CENP-H PF05837.12 EEA26630.1 - 0.012 16.0 2.0 0.015 15.7 2.0 1.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF16 PF01519.16 EEA26630.1 - 0.019 15.4 0.1 0.024 15.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 PEP-utilisers_N PF05524.13 EEA26630.1 - 0.079 13.1 2.0 0.13 12.4 2.0 1.4 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal DivIC PF04977.15 EEA26630.1 - 0.095 12.5 4.2 0.15 11.8 4.2 1.4 1 0 0 1 1 1 0 Septum formation initiator V_ATPase_I PF01496.19 EEA26630.1 - 0.16 9.8 0.6 0.17 9.8 0.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 EEA26630.1 - 0.28 10.4 1.7 0.32 10.2 1.7 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF1043 PF06295.12 EEA26630.1 - 0.37 10.8 4.8 0.94 9.5 4.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) CENP-H PF05837.12 EEA26631.1 - 0.017 15.5 2.7 0.029 14.8 2.7 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) PEP-utilisers_N PF05524.13 EEA26631.1 - 0.051 13.7 0.2 0.092 12.9 0.2 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal V_ATPase_I PF01496.19 EEA26631.1 - 0.06 11.3 0.3 0.064 11.2 0.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 EEA26631.1 - 0.14 11.4 2.4 0.17 11.1 2.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF16 PF01519.16 EEA26631.1 - 0.15 12.6 2.6 0.25 11.9 2.2 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 Tweety PF04906.13 EEA26631.1 - 0.2 10.3 0.1 0.27 9.9 0.1 1.1 1 0 0 1 1 1 0 Tweety DivIC PF04977.15 EEA26631.1 - 0.25 11.1 5.4 0.13 12.1 2.8 1.9 2 0 0 2 2 2 0 Septum formation initiator DUF1043 PF06295.12 EEA26631.1 - 0.61 10.1 3.5 0.71 9.9 2.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) LcrG PF07216.12 EEA26631.1 - 0.61 10.0 3.4 0.49 10.3 1.1 2.0 2 0 0 2 2 2 0 LcrG protein JIP_LZII PF16471.5 EEA26631.1 - 0.66 10.2 6.4 7.2 6.9 0.2 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Zn_clus PF00172.18 EEA26631.1 - 2 8.6 8.3 15 5.8 8.3 2.1 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain RT_RNaseH PF17917.1 EEA26632.1 - 2.7e-25 88.7 0.1 5.9e-25 87.6 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EEA26632.1 - 8.8e-23 80.2 0.6 2e-22 79.0 0.6 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EEA26632.1 - 3.7e-15 56.1 0.0 8.7e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 EEA26632.1 - 5.6e-14 52.0 0.0 1.1e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 EEA26632.1 - 0.0038 17.4 0.0 0.009 16.2 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 EEA26632.1 - 0.086 12.6 0.0 0.28 11.0 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain DUF4939 PF16297.5 EEA26633.1 - 7.4e-09 35.5 0.0 1.5e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC PF00098.23 EEA26633.1 - 6.1e-05 22.9 5.2 0.0001 22.2 5.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EEA26633.1 - 0.0078 16.2 3.6 0.02 14.9 3.6 1.7 1 0 0 1 1 1 1 Zinc knuckle DUF1489 PF07370.11 EEA26633.1 - 0.057 13.2 0.6 0.11 12.2 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) zf-CCHC_5 PF14787.6 EEA26633.1 - 0.064 13.0 2.7 0.13 12.0 2.2 1.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 EEA26633.1 - 0.19 11.6 3.7 0.31 10.9 3.7 1.3 1 0 0 1 1 1 0 Zinc knuckle Pox_A_type_inc PF04508.12 EEA26633.1 - 0.82 9.6 0.0 0.82 9.6 0.0 2.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Iron_permease PF04120.12 EEA26634.1 - 2.2e-39 134.1 16.2 1.7e-19 69.9 0.0 4.3 3 2 1 4 4 4 4 Low affinity iron permease DUF2839 PF10999.8 EEA26634.1 - 0.043 14.2 0.2 0.043 14.2 0.2 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2839) Gly_transf_sug PF04488.15 EEA26635.1 - 4.3e-18 65.7 0.0 7.7e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Cyt_b-c1_8 PF10890.8 EEA26635.1 - 0.00029 21.1 0.3 0.23 11.9 0.0 2.5 2 0 0 2 2 2 2 Cytochrome b-c1 complex subunit 8 COX2_TM PF02790.15 EEA26635.1 - 0.077 13.1 0.2 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF4051 PF13260.6 EEA26635.1 - 0.12 12.1 3.6 0.24 11.2 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) RVT_2 PF07727.14 EEA26636.1 - 2.8e-38 131.9 0.2 5e-38 131.1 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EEA26636.1 - 1.8e-07 30.9 0.0 4.3e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EEA26636.1 - 0.00047 20.3 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EEA26636.1 - 0.023 14.2 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flg_hook PF02120.16 EEA26636.1 - 0.068 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Orthopox_F14 PF06076.12 EEA26636.1 - 0.1 12.9 3.2 0.27 11.5 3.2 1.7 1 0 0 1 1 1 0 Orthopoxvirus F14 protein REV1_C PF16727.5 EEA26637.1 - 0.083 13.3 3.6 3.5 8.1 0.3 2.4 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Sulfotransfer_4 PF17784.1 EEA26637.1 - 2.1 8.1 6.1 0.57 10.0 0.2 2.6 3 0 0 3 3 3 0 Sulfotransferase domain TPR_10 PF13374.6 EEA26638.1 - 5.9e-20 70.5 0.1 4.9e-09 35.8 0.0 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA26638.1 - 9.5e-17 61.1 0.1 1.9e-16 60.1 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA26638.1 - 3.9e-10 39.1 4.5 7.8e-05 22.3 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA26638.1 - 1.7e-09 37.0 0.0 0.00095 19.0 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA26638.1 - 1.4e-07 31.2 4.4 0.0031 17.6 0.2 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA26638.1 - 5e-06 26.2 2.1 0.02 15.0 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA26638.1 - 6.2e-05 22.5 0.1 0.00012 21.6 0.1 1.4 1 1 0 1 1 1 1 MalT-like TPR region TPR_14 PF13428.6 EEA26638.1 - 0.00011 22.7 0.2 1.6 9.7 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA26638.1 - 0.00089 19.5 0.4 0.58 10.7 0.3 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA26638.1 - 0.0052 16.4 2.1 1.6 8.5 0.0 2.7 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.6 EEA26638.1 - 0.011 16.3 1.6 1.1 10.0 0.0 3.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EEA26638.1 - 0.013 15.2 2.7 1 9.0 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TipAS PF07739.13 EEA26638.1 - 0.057 14.0 0.1 0.48 11.0 0.0 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain RPN6_N PF18055.1 EEA26638.1 - 0.071 13.5 0.3 0.56 10.6 0.7 2.1 1 1 1 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain DUF4810 PF16068.5 EEA26638.1 - 0.1 13.2 0.9 2.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) 14-3-3 PF00244.20 EEA26638.1 - 0.1 12.1 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 14-3-3 protein TPR_19 PF14559.6 EEA26638.1 - 0.15 12.6 1.1 0.62 10.6 1.1 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA26638.1 - 0.18 12.5 3.8 3.3 8.5 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Cutinase PF01083.22 EEA26639.1 - 3.5e-37 128.1 0.4 4.4e-37 127.8 0.4 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EEA26639.1 - 4.8e-05 23.0 0.0 7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain DUF2974 PF11187.8 EEA26639.1 - 0.03 13.9 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_2 PF02230.16 EEA26639.1 - 0.053 13.3 0.0 0.081 12.7 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase VirJ PF06057.11 EEA26639.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) FSH1 PF03959.13 EEA26639.1 - 0.21 11.2 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Pollen_allerg_1 PF01357.21 EEA26641.1 - 2.7e-19 69.0 0.1 4.7e-19 68.2 0.1 1.4 1 0 0 1 1 1 1 Pollen allergen DPBB_1 PF03330.18 EEA26641.1 - 1.2e-05 25.4 0.0 6.3e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Lytic transglycolase HD PF01966.22 EEA26642.1 - 7.7e-08 32.6 0.8 1.3e-07 31.9 0.8 1.5 1 1 0 1 1 1 1 HD domain HDOD PF08668.12 EEA26642.1 - 0.0025 17.3 0.1 0.0041 16.6 0.1 1.4 1 1 0 1 1 1 1 HDOD domain MIOX PF05153.15 EEA26642.1 - 0.013 15.1 0.1 0.02 14.5 0.1 1.2 1 0 0 1 1 1 0 Myo-inositol oxygenase Sugar_tr PF00083.24 EEA26643.1 - 1.3e-36 126.5 27.7 1.9e-24 86.4 5.8 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EEA26643.1 - 3.1e-23 82.3 34.7 3.6e-13 49.2 11.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_3 PF00202.21 EEA26644.1 - 5e-38 130.8 0.0 1e-18 67.3 0.0 3.1 3 0 0 3 3 3 3 Aminotransferase class-III AAA_26 PF13500.6 EEA26644.1 - 5.7e-23 81.8 0.0 3.8e-22 79.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain Aminotran_1_2 PF00155.21 EEA26645.1 - 3.6e-36 125.1 0.0 4.1e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA26645.1 - 0.00026 19.7 0.0 0.00039 19.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme BATS PF06968.13 EEA26646.1 - 6.6e-22 77.5 0.1 2.1e-21 75.9 0.0 1.9 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EEA26646.1 - 1.8e-15 57.7 0.0 9.1e-15 55.4 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily TauD PF02668.16 EEA26647.1 - 5.6e-34 118.2 0.0 8.3e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family p450 PF00067.22 EEA26647.1 - 7.2e-25 87.7 0.0 2.1e-24 86.1 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 CsiD PF08943.10 EEA26647.1 - 0.08 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 CsiD FAD_binding_4 PF01565.23 EEA26648.1 - 3.8e-23 81.8 2.5 6.9e-23 80.9 2.5 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA26648.1 - 8.9e-09 35.3 0.0 2.4e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like ATP_transf PF09830.9 EEA26649.1 - 3.5e-18 65.5 0.0 3.4e-16 59.1 0.0 2.4 2 0 0 2 2 2 2 ATP adenylyltransferase HIT PF01230.23 EEA26649.1 - 0.13 13.0 0.1 0.35 11.6 0.1 1.8 2 0 0 2 2 2 0 HIT domain CcmH PF03918.14 EEA26650.1 - 0.014 14.7 0.4 0.039 13.3 0.4 1.7 1 0 0 1 1 1 0 Cytochrome C biogenesis protein FAD_binding_4 PF01565.23 EEA26652.1 - 7.6e-20 71.1 3.3 1.6e-19 70.1 3.3 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EEA26652.1 - 3.1e-07 30.4 0.1 8.2e-07 29.0 0.1 1.8 1 0 0 1 1 1 1 Berberine and berberine like Methyltransf_31 PF13847.6 EEA26653.1 - 3.6e-27 95.0 0.0 4.6e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA26653.1 - 3.6e-23 82.0 0.0 7.1e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA26653.1 - 1.4e-22 80.2 0.0 2.6e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA26653.1 - 3.3e-18 65.9 0.0 5.3e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EEA26653.1 - 2.4e-15 57.1 0.0 3.9e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA26653.1 - 3.6e-12 46.4 0.0 5.6e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EEA26653.1 - 5.2e-12 45.8 0.0 8.1e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 EEA26653.1 - 2.7e-08 33.8 0.0 3.7e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EEA26653.1 - 2e-07 30.7 0.0 3.1e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EEA26653.1 - 2.2e-07 30.5 0.0 3.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_9 PF08003.11 EEA26653.1 - 5.5e-06 25.5 0.1 8.4e-05 21.6 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) NodS PF05401.11 EEA26653.1 - 2.6e-05 23.9 0.0 3.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) DREV PF05219.12 EEA26653.1 - 5.4e-05 22.4 0.0 8.2e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase GidB PF02527.15 EEA26653.1 - 0.00048 19.5 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G TehB PF03848.14 EEA26653.1 - 0.00081 18.9 0.0 0.0011 18.4 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB RrnaAD PF00398.20 EEA26653.1 - 0.0014 17.8 0.0 0.0019 17.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.7 EEA26653.1 - 0.0017 18.3 0.0 0.0027 17.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EEA26653.1 - 0.0038 17.1 0.0 0.059 13.2 0.0 2.0 2 0 0 2 2 2 1 Hypothetical methyltransferase PrmA PF06325.13 EEA26653.1 - 0.013 14.9 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EEA26653.1 - 0.014 15.3 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EEA26653.1 - 0.027 13.8 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase UPF0020 PF01170.18 EEA26653.1 - 0.042 13.5 0.1 0.24 11.1 0.1 1.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Glyoxalase PF00903.25 EEA26654.1 - 8.9e-05 22.7 0.0 0.00015 21.9 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EEA26654.1 - 0.096 12.8 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain MFS_1 PF07690.16 EEA26655.1 - 3.3e-26 92.1 30.7 4e-26 91.8 29.8 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Acyl_transf_3 PF01757.22 EEA26655.1 - 0.0043 16.2 10.1 0.0043 16.2 10.1 2.8 2 1 0 2 2 2 1 Acyltransferase family But2 PF09792.9 EEA26656.1 - 6.9e-57 191.8 5.7 6.9e-57 191.8 5.7 1.7 2 0 0 2 2 2 1 Ubiquitin 3 binding protein But2 C-terminal domain KxDL PF10241.9 EEA26657.1 - 4.9e-31 106.8 0.1 6.6e-31 106.4 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein Cir_N PF10197.9 EEA26658.1 - 1.7e-06 28.1 4.4 1.7e-06 28.1 4.4 4.1 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR FAM91_C PF14648.6 EEA26658.1 - 0.054 12.3 0.3 0.096 11.5 0.3 1.3 1 0 0 1 1 1 0 FAM91 C-terminus PrmA PF06325.13 EEA26659.1 - 5.9e-11 42.3 0.0 1.2e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EEA26659.1 - 7.2e-11 42.6 0.0 2.2e-10 41.1 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA26659.1 - 5.2e-09 36.6 0.0 1.9e-08 34.8 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA26659.1 - 2.9e-08 33.6 0.0 5.4e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EEA26659.1 - 2.8e-06 27.3 0.0 6.1e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA26659.1 - 5.4e-06 26.1 0.1 9.8e-06 25.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EEA26659.1 - 5.8e-06 26.2 0.0 3.8e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EEA26659.1 - 0.0016 18.2 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 EEA26659.1 - 0.0018 17.3 0.1 0.0034 16.4 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 EEA26659.1 - 0.0031 16.9 0.1 0.007 15.7 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EEA26659.1 - 0.0032 16.8 0.0 0.006 15.9 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 EEA26659.1 - 0.0053 17.5 0.0 0.013 16.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EEA26659.1 - 0.0061 16.3 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein CMAS PF02353.20 EEA26659.1 - 0.016 14.5 0.0 0.028 13.7 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TehB PF03848.14 EEA26659.1 - 0.017 14.6 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 Tellurite resistance protein TehB Prefoldin_2 PF01920.20 EEA26659.1 - 0.018 15.0 2.8 0.088 12.8 3.4 1.8 2 0 0 2 2 2 0 Prefoldin subunit Methyltransf_16 PF10294.9 EEA26659.1 - 0.024 14.4 0.0 0.078 12.7 0.0 1.9 2 0 0 2 2 2 0 Lysine methyltransferase SMODS PF18144.1 EEA26659.1 - 0.032 14.4 0.6 0.71 10.0 0.2 2.8 3 0 0 3 3 3 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain PRMT5 PF05185.16 EEA26659.1 - 0.034 14.0 0.1 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase UPF0020 PF01170.18 EEA26659.1 - 0.064 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.15 EEA26659.1 - 0.08 12.6 0.1 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Mo25 PF08569.11 EEA26660.1 - 1e-125 419.5 0.0 1.2e-125 419.3 0.0 1.0 1 0 0 1 1 1 1 Mo25-like RepA_N PF06970.11 EEA26660.1 - 0.08 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus RabGAP-TBC PF00566.18 EEA26661.1 - 2e-34 119.1 0.0 3.4e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain p450 PF00067.22 EEA26662.1 - 3.5e-83 279.9 0.0 4.2e-83 279.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ELO PF01151.18 EEA26663.1 - 3.9e-64 216.6 11.6 4.8e-64 216.3 11.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family 4HBT_2 PF13279.6 EEA26664.1 - 5.4e-10 39.8 0.0 9.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily WBS_methylT PF12589.8 EEA26664.1 - 0.033 14.9 1.5 0.065 14.0 1.5 1.4 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome MFS_1 PF07690.16 EEA26665.1 - 2.3e-34 118.9 59.3 2.3e-34 118.9 59.3 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA26665.1 - 0.00016 20.3 30.2 0.00035 19.1 30.2 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2722 PF10846.8 EEA26666.1 - 0.84 8.5 39.5 33 3.3 39.5 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2722) DIL PF01843.19 EEA26667.1 - 4.6e-30 103.9 2.0 9.6e-30 102.9 2.0 1.6 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 EEA26667.1 - 1.3e-14 54.6 0.1 5.6e-14 52.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA26667.1 - 1e-10 41.6 0.0 6.7e-05 23.1 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA26667.1 - 1.1e-08 35.4 0.0 6.7e-05 23.4 0.0 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA26667.1 - 1.9e-08 34.3 0.0 0.0085 16.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EEA26667.1 - 7.3e-07 29.0 1.4 0.0047 17.3 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat RasGEF PF00617.19 EEA26668.1 - 2.4e-43 148.4 0.3 4.2e-43 147.6 0.3 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EEA26668.1 - 3.6e-13 49.7 0.1 1.1e-12 48.0 0.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif ARL6IP6 PF15062.6 EEA26668.1 - 0.07 13.3 0.9 13 6.0 0.1 3.0 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix Crystallin PF00525.18 EEA26668.1 - 0.12 12.5 2.4 7.3 6.8 0.1 3.1 3 0 0 3 3 3 0 Alpha crystallin A chain, N terminal Peptidase_M13_N PF05649.13 EEA26669.1 - 4.5e-90 303.1 0.0 7.3e-90 302.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EEA26669.1 - 3.2e-63 213.0 0.0 5.2e-63 212.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Transferase PF02458.15 EEA26671.1 - 5.6e-10 38.4 0.0 2.4e-09 36.4 0.0 1.8 1 1 0 1 1 1 1 Transferase family HTH_Tnp_Mu_1 PF02316.16 EEA26671.1 - 0.019 15.1 0.0 0.048 13.8 0.0 1.6 1 0 0 1 1 1 0 Mu DNA-binding domain MFS_1 PF07690.16 EEA26672.1 - 1.8e-07 30.4 35.8 3.4e-07 29.5 35.4 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EEA26672.1 - 3.1e-07 30.3 5.2 3.1e-07 30.3 5.2 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 PsbY PF06298.11 EEA26672.1 - 0.057 13.3 3.5 2.1 8.3 0.2 3.0 2 0 0 2 2 2 0 Photosystem II protein Y (PsbY) Glyco_hydro_31 PF01055.26 EEA26673.1 - 1.6e-156 522.0 3.7 2.1e-156 521.5 3.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EEA26673.1 - 1.5e-40 138.0 0.0 3.6e-40 136.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase CBM_20 PF00686.19 EEA26673.1 - 1.8e-19 69.4 0.2 3.9e-19 68.3 0.2 1.6 1 0 0 1 1 1 1 Starch binding domain Gal_mutarotas_2 PF13802.6 EEA26673.1 - 2.7e-10 40.4 1.3 9.4e-10 38.7 1.3 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like Methyltransf_2 PF00891.18 EEA26674.1 - 2.5e-22 79.2 0.1 6.6e-22 77.8 0.1 1.6 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EEA26674.1 - 0.0082 16.8 0.0 0.015 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Vmethyltransf PF01660.17 EEA26674.1 - 0.036 13.0 0.1 0.053 12.4 0.1 1.2 1 0 0 1 1 1 0 Viral methyltransferase Methyltransf_12 PF08242.12 EEA26674.1 - 0.1 13.4 0.0 0.45 11.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Caps_synth PF05704.12 EEA26675.1 - 0.001 18.5 1.3 0.003 17.0 0.1 2.3 1 1 1 2 2 2 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 EEA26675.1 - 0.0018 18.8 0.0 0.0059 17.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif FAD_binding_3 PF01494.19 EEA26676.1 - 7.4e-19 68.2 0.3 2.6e-11 43.4 0.0 2.4 1 1 1 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EEA26676.1 - 0.00012 21.4 0.0 0.00078 18.8 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA26676.1 - 0.00051 20.2 0.1 0.0016 18.6 0.0 1.9 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA26676.1 - 0.0013 17.8 0.2 0.09 11.8 0.1 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 EEA26676.1 - 0.015 15.8 0.0 0.19 12.3 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA26676.1 - 0.023 14.3 0.5 0.11 12.1 0.3 2.0 1 1 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 EEA26676.1 - 0.027 13.7 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EEA26676.1 - 0.035 12.8 0.0 0.057 12.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EEA26676.1 - 0.05 12.4 0.0 3.2 6.5 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EEA26676.1 - 0.07 12.4 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 EEA26676.1 - 0.14 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SE PF08491.10 EEA26676.1 - 0.24 10.4 0.0 0.58 9.2 0.0 1.5 2 0 0 2 2 2 0 Squalene epoxidase Peptidase_C1_2 PF03051.15 EEA26678.1 - 6.4e-159 529.4 0.0 7.4e-159 529.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EEA26678.1 - 4.5e-08 33.5 0.3 0.0013 18.9 0.3 2.4 2 0 0 2 2 2 2 Papain family cysteine protease DUF4296 PF14129.6 EEA26678.1 - 0.027 15.1 0.0 0.058 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) MFS_1 PF07690.16 EEA26679.1 - 1.4e-27 96.6 32.3 1.4e-27 96.6 32.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA26679.1 - 0.00067 19.1 16.1 0.016 14.6 16.1 2.4 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Aminotran_4 PF01063.19 EEA26680.1 - 3.6e-28 98.9 0.0 5e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Kinesin PF00225.23 EEA26681.1 - 1.5e-111 372.6 0.4 4.3e-111 371.0 0.4 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EEA26681.1 - 3.1e-26 92.1 0.1 1e-25 90.5 0.1 1.9 1 0 0 1 1 1 1 Microtubule binding HAP1_N PF04849.13 EEA26681.1 - 5.2 6.2 55.0 0.94 8.6 18.4 4.0 3 1 0 3 3 3 0 HAP1 N-terminal conserved region TFA2_Winged_2 PF18121.1 EEA26681.1 - 5.6 6.7 6.1 4 7.2 0.3 3.6 4 0 0 4 4 4 0 TFA2 Winged helix domain 2 DUF2048 PF09752.9 EEA26681.1 - 6.9 5.6 7.5 0.16 11.1 0.4 1.8 2 0 0 2 2 2 0 Abhydrolase domain containing 18 UQ_con PF00179.26 EEA26682.1 - 1.7e-51 173.5 0.0 1.9e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA26682.1 - 0.0026 17.5 0.0 0.0029 17.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EEA26682.1 - 0.094 13.0 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 RWD domain Thiolase_N PF00108.23 EEA26683.1 - 4.1e-95 318.0 2.2 6.5e-95 317.4 2.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA26683.1 - 1.1e-38 131.6 0.3 1.1e-38 131.6 0.3 2.0 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EEA26683.1 - 6.1e-05 22.7 4.2 0.00011 21.9 3.1 2.0 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain 7TMR-HDED PF07697.11 EEA26683.1 - 0.017 15.3 0.1 0.049 13.7 0.2 1.5 1 1 0 1 1 1 0 7TM-HD extracellular Inhibitor_I66 PF16850.5 EEA26683.1 - 0.054 13.4 0.1 7.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Peptidase inhibitor I66 ACP_syn_III PF08545.10 EEA26683.1 - 0.44 10.4 3.4 22 5.0 0.2 3.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 EEA26684.1 - 3.6e-95 318.2 2.2 5.7e-95 317.6 2.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA26684.1 - 3.6e-12 46.0 0.2 3.6e-12 46.0 0.2 2.1 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EEA26684.1 - 5.1e-05 23.0 3.9 0.0001 22.0 3.1 1.9 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain 7TMR-HDED PF07697.11 EEA26684.1 - 0.015 15.4 0.1 0.023 14.8 0.1 1.5 1 1 0 1 1 1 0 7TM-HD extracellular Inhibitor_I66 PF16850.5 EEA26684.1 - 0.048 13.5 0.1 6.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Peptidase inhibitor I66 Glyco_transf_4 PF13439.6 EEA26685.1 - 1.5e-07 31.6 0.1 3.5e-07 30.4 0.1 1.6 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EEA26685.1 - 9.9e-07 29.3 0.0 1.1e-05 25.9 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EEA26685.1 - 4.3e-05 24.0 0.0 8.7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 EEA26685.1 - 0.00016 21.2 0.0 0.00045 19.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EEA26685.1 - 0.00019 21.7 0.0 0.00044 20.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 RMI1_N PF08585.12 EEA26685.1 - 0.011 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 RecQ mediated genome instability protein Cation_efflux PF01545.21 EEA26686.1 - 3.2e-46 157.6 13.1 3.2e-46 157.6 13.1 3.8 3 2 0 3 3 3 1 Cation efflux family TFIIIC_delta PF12657.7 EEA26687.1 - 6.5e-42 143.5 1.4 1.2e-41 142.6 1.4 1.5 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EEA26687.1 - 1.1e-28 99.2 0.5 2.3e-28 98.1 0.5 1.6 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex UQ_con PF00179.26 EEA26688.1 - 1.7e-44 150.9 0.0 1.9e-44 150.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF4395 PF14340.6 EEA26689.1 - 0.66 10.3 0.0 0.66 10.3 0.0 3.5 4 1 0 4 4 4 0 Domain of unknown function (DUF4395) Choline_kinase PF01633.20 EEA26690.1 - 1.3e-09 38.0 0.1 3.1e-09 36.8 0.1 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EEA26690.1 - 2.3e-09 37.6 0.0 3.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EEA26690.1 - 2.1e-05 23.6 0.3 3.1e-05 23.0 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EEA26690.1 - 2.7e-05 23.6 0.1 6e-05 22.5 0.1 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase Zn_clus PF00172.18 EEA26691.1 - 1.6e-05 24.9 12.9 2.8e-05 24.2 12.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA26691.1 - 4.4e-05 22.6 0.0 0.0001 21.5 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain NPV_P10 PF05531.12 EEA26691.1 - 0.63 10.5 2.7 30 5.2 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FYVE PF01363.21 EEA26692.1 - 4.6e-21 74.7 1.6 4.6e-21 74.7 1.6 3.0 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EEA26692.1 - 2.5e-08 34.1 4.8 2.5e-08 34.1 4.8 3.4 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 EEA26692.1 - 8.3e-06 25.5 4.0 8.3e-06 25.5 4.0 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA26692.1 - 0.00011 21.8 7.5 0.00014 21.5 4.6 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EEA26692.1 - 0.0043 16.9 4.4 0.0043 16.9 4.4 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 EEA26692.1 - 0.0061 16.8 1.0 0.0061 16.8 1.0 2.3 2 0 0 2 2 2 1 FYVE-type zinc finger zf-rbx1 PF12678.7 EEA26692.1 - 0.0061 16.8 5.5 0.0061 16.8 5.5 3.5 3 1 0 3 3 3 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EEA26692.1 - 0.016 15.2 3.8 0.016 15.2 3.8 3.7 4 0 0 4 4 4 0 RING-type zinc-finger Zn-C2H2_12 PF18112.1 EEA26692.1 - 0.27 11.8 6.5 4.3 7.9 0.1 3.4 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain RINGv PF12906.7 EEA26692.1 - 0.28 11.4 9.2 0.72 10.0 5.4 2.9 2 0 0 2 2 2 0 RING-variant domain DZR PF12773.7 EEA26692.1 - 5.1 7.2 13.4 8.3 6.5 1.3 2.9 2 1 0 2 2 2 0 Double zinc ribbon Vezatin PF12632.7 EEA26693.1 - 0.014 14.8 0.2 0.026 13.9 0.2 1.4 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes DcuA_DcuB PF03605.14 EEA26693.1 - 0.028 13.3 0.0 0.033 13.1 0.0 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF2749 PF10907.8 EEA26693.1 - 0.029 14.5 0.1 0.093 12.9 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) DUF2207 PF09972.9 EEA26693.1 - 0.03 13.1 0.0 0.032 13.0 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HOOK PF05622.12 EEA26693.1 - 0.094 10.9 1.2 0.12 10.5 1.2 1.0 1 0 0 1 1 1 0 HOOK protein DUF4366 PF14283.6 EEA26693.1 - 0.1 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) MurJ PF03023.14 EEA26693.1 - 0.15 10.7 0.1 0.19 10.3 0.1 1.1 1 0 0 1 1 1 0 Lipid II flippase MurJ RskA PF10099.9 EEA26693.1 - 0.17 12.2 0.0 0.2 12.0 0.0 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA zf-CCCH PF00642.24 EEA26694.1 - 3.3e-08 33.3 20.0 3e-07 30.2 2.5 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EEA26694.1 - 0.00083 19.1 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EEA26694.1 - 0.0058 16.7 3.3 0.0058 16.7 3.3 3.3 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 EEA26694.1 - 0.0094 16.6 3.0 0.5 11.1 0.2 2.5 2 0 0 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 EEA26694.1 - 2.4 8.4 8.0 0.48 10.6 1.4 2.4 2 2 0 2 2 2 0 Zinc-finger containing family Amidase PF01425.21 EEA26695.1 - 1.2e-88 298.1 0.0 2e-88 297.3 0.0 1.4 1 1 0 1 1 1 1 Amidase But2 PF09792.9 EEA26695.1 - 0.15 12.5 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin 3 binding protein But2 C-terminal domain adh_short PF00106.25 EEA26696.1 - 1.6e-23 83.2 0.2 2.3e-23 82.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA26696.1 - 1e-22 80.8 0.1 1.3e-22 80.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EEA26696.1 - 9.7e-10 38.6 0.2 4.8e-09 36.4 0.2 1.9 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EEA26696.1 - 3.1e-09 37.0 0.0 7.1e-09 35.8 0.0 1.6 2 0 0 2 2 2 1 KR domain NmrA PF05368.13 EEA26696.1 - 1.4e-05 24.8 0.1 2.4e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 EEA26696.1 - 0.0025 18.1 0.1 0.0085 16.4 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain 3Beta_HSD PF01073.19 EEA26696.1 - 0.057 12.4 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF2953 PF11167.8 EEA26696.1 - 0.16 12.0 0.2 9.8 6.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2953) Zn_clus PF00172.18 EEA26697.1 - 6e-05 23.1 7.9 0.00011 22.2 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-PHD-like PF15446.6 EEA26697.1 - 0.11 12.1 3.9 0.21 11.2 3.9 1.4 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain FXR_C1 PF16096.5 EEA26698.1 - 0.16 12.2 6.7 0.065 13.4 2.2 2.5 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 HTH_Tnp_Tc5 PF03221.16 EEA26699.1 - 3.3e-10 39.9 0.3 6.4e-10 38.9 0.3 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain VWA_3 PF13768.6 EEA26699.1 - 0.076 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Pkinase PF00069.25 EEA26701.1 - 1.8e-28 99.6 0.0 7.9e-28 97.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26701.1 - 6.9e-14 51.7 0.0 1.5e-13 50.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EEA26701.1 - 0.013 14.9 0.1 0.032 13.6 0.1 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA26701.1 - 0.015 14.1 0.0 0.031 13.1 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase DDE_1 PF03184.19 EEA26702.1 - 4.5e-13 49.2 0.0 9e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA26702.1 - 1.1e-11 44.5 0.7 7.4e-11 41.9 0.0 2.8 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA26702.1 - 3.5 7.6 6.9 0.55 10.2 1.6 2.4 2 0 0 2 2 2 0 Myb DNA-binding like MFS_1 PF07690.16 EEA26704.1 - 4.3e-12 45.6 13.4 4.3e-12 45.6 13.4 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Orf78 PF06024.12 EEA26704.1 - 0.19 12.0 0.0 1.9 8.8 0.0 2.4 2 0 0 2 2 2 0 Orf78 (ac78) Ac76 PF05814.11 EEA26704.1 - 1.1 9.3 0.0 1.1 9.3 0.0 3.2 4 0 0 4 4 4 0 Orf76 (Ac76) GST_N_2 PF13409.6 EEA26706.1 - 3.8e-22 78.4 0.0 6.6e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA26706.1 - 4.1e-15 55.6 0.0 3.8e-14 52.5 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA26706.1 - 7.4e-05 22.9 0.0 0.00015 21.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA26706.1 - 0.00095 19.5 0.0 0.02 15.3 0.0 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA26706.1 - 0.0015 18.7 0.0 0.0032 17.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pyr_redox_2 PF07992.14 EEA26707.1 - 2e-31 109.3 0.2 2.4e-31 109.1 0.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA26707.1 - 1.4e-06 28.7 1.2 2.8e-05 24.6 0.4 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DUF498 PF04430.14 EEA26707.1 - 0.00036 20.6 0.0 0.00095 19.2 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) NAD_binding_9 PF13454.6 EEA26707.1 - 0.046 13.7 1.4 3 7.8 0.0 3.4 2 2 2 4 4 4 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EEA26707.1 - 0.077 12.2 0.1 0.19 11.0 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain C2 PF00168.30 EEA26708.1 - 4.8e-72 238.8 0.0 3.1e-19 69.2 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 EEA26708.1 - 0.0043 16.5 0.0 0.0094 15.4 0.0 1.6 1 1 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain TTR-52 PF01060.23 EEA26708.1 - 0.13 13.0 0.0 1.4 9.7 0.0 2.7 3 0 0 3 3 3 0 Transthyretin-like family UDPGP PF01704.18 EEA26709.1 - 4.7e-192 638.2 0.0 5.5e-192 637.9 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 EEA26709.1 - 0.31 9.8 3.8 1.8 7.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4301) UDPGP PF01704.18 EEA26710.1 - 4.7e-192 638.2 0.0 5.5e-192 637.9 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 EEA26710.1 - 0.31 9.8 3.8 1.8 7.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4301) Zn_clus PF00172.18 EEA26712.1 - 1.4e-06 28.3 10.1 3.3e-06 27.1 10.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA26712.1 - 0.00017 20.7 0.1 0.00035 19.7 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain PTR2 PF00854.21 EEA26713.1 - 4.7e-92 308.9 9.3 7.8e-92 308.1 9.3 1.3 1 0 0 1 1 1 1 POT family IF4E PF01652.18 EEA26714.1 - 7e-54 181.9 0.4 8.9e-54 181.6 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Mpv17_PMP22 PF04117.12 EEA26715.1 - 2.5e-22 78.9 1.4 2.7e-22 78.7 0.3 1.6 2 0 0 2 2 2 1 Mpv17 / PMP22 family Ribosomal_S5 PF00333.20 EEA26716.1 - 3.6e-27 94.1 2.2 6.5e-27 93.3 0.8 2.1 3 0 0 3 3 3 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EEA26716.1 - 3.2e-23 80.9 0.0 5.3e-23 80.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Phage_tail_NK PF16532.5 EEA26716.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales Zn_clus PF00172.18 EEA26718.1 - 1.9e-08 34.3 3.0 3.6e-08 33.4 3.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA26718.1 - 3.9e-08 32.5 0.7 6.1e-08 31.9 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.13 EEA26719.1 - 4.7e-69 232.1 15.8 4.7e-69 232.1 15.8 1.6 2 0 0 2 2 2 1 RTA1 like protein DUF3483 PF11982.8 EEA26719.1 - 0.071 12.7 5.0 0.029 14.0 2.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) TMEM100 PF16311.5 EEA26719.1 - 0.1 12.2 0.1 0.26 10.9 0.1 1.7 1 0 0 1 1 1 0 Transmembrane protein 100 7TMR-DISM_7TM PF07695.11 EEA26719.1 - 6.7 6.5 24.3 0.13 12.2 10.2 2.6 2 1 0 2 2 2 0 7TM diverse intracellular signalling Bac_rhodopsin PF01036.18 EEA26720.1 - 1.1e-34 120.0 16.0 1.3e-34 119.7 16.0 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Phage_holin_3_6 PF07332.11 EEA26720.1 - 0.039 14.0 11.7 0.039 14.0 3.5 2.8 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF805 PF05656.14 EEA26720.1 - 1.4 9.4 16.8 0.51 10.8 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF805) DUF3792 PF12670.7 EEA26720.1 - 3.8 7.7 12.1 4.3 7.5 3.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) tRNA-synt_1 PF00133.22 EEA26721.1 - 5.1e-162 540.2 0.0 7.2e-162 539.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EEA26721.1 - 1.2e-21 77.3 1.4 2.5e-21 76.2 1.4 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EEA26721.1 - 1.1e-19 70.5 0.2 2.2e-11 43.1 0.0 4.6 4 1 0 4 4 4 3 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.14 EEA26721.1 - 0.0055 16.5 3.8 0.015 15.1 3.8 1.8 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS tRNA-synt_1e PF01406.19 EEA26721.1 - 0.044 13.1 0.0 7.6 5.8 0.0 2.8 2 1 1 3 3 3 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 EEA26721.1 - 0.051 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 Herpes_UL31 PF02718.14 EEA26721.1 - 0.19 10.7 0.0 0.33 9.9 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL31-like protein ADH_zinc_N PF00107.26 EEA26722.1 - 1.9e-26 92.5 0.1 3.7e-26 91.6 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA26722.1 - 6.3e-20 72.6 0.1 1.1e-19 71.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA26722.1 - 5.7e-06 26.2 0.0 1.9e-05 24.5 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EEA26722.1 - 0.057 13.3 0.1 0.65 9.9 0.1 2.4 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase UPF0183 PF03676.14 EEA26723.1 - 3.1e-59 201.3 0.0 1.5e-38 133.2 0.0 2.8 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) Kinesin PF00225.23 EEA26724.1 - 5.4e-109 364.1 1.5 1.3e-108 362.8 1.5 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EEA26724.1 - 7.2e-25 87.7 0.4 4.3e-24 85.1 0.0 2.6 3 0 0 3 3 3 1 Microtubule binding Microtub_bind PF13931.6 EEA26724.1 - 2.2e-11 44.3 3.2 2.2e-11 44.3 3.2 4.4 4 1 0 4 4 4 1 Kinesin-associated microtubule-binding Baculo_PEP_C PF04513.12 EEA26724.1 - 0.0089 16.1 0.0 0.0089 16.1 0.0 5.9 2 2 4 6 6 6 3 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 EEA26724.1 - 1.8 8.4 48.2 8.4 6.2 13.5 4.7 1 1 2 3 3 3 0 Apolipoprotein A1/A4/E domain Dscam_C PF12355.8 EEA26725.1 - 0.11 13.4 0.8 0.11 13.4 0.8 2.3 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal zf-ANAPC11 PF12861.7 EEA26726.1 - 8.2e-47 157.2 9.9 9.5e-47 157.0 9.9 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EEA26726.1 - 4.6e-21 74.9 9.9 6.5e-21 74.4 9.9 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EEA26726.1 - 7.4e-08 32.6 15.1 1.9e-06 28.1 15.2 2.5 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EEA26726.1 - 5.1e-05 23.2 8.9 0.00057 19.9 5.7 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA26726.1 - 8e-05 22.4 3.6 8e-05 22.4 3.6 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA26726.1 - 0.00073 19.4 12.6 0.0028 17.5 12.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EEA26726.1 - 0.0011 18.8 10.5 0.034 13.9 7.2 2.7 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EEA26726.1 - 0.0029 17.4 11.3 0.003 17.4 5.8 2.3 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA26726.1 - 0.0036 17.4 1.6 0.0036 17.4 1.6 2.4 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING Rad50_zn_hook PF04423.14 EEA26726.1 - 0.018 14.9 0.6 0.44 10.4 0.0 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_5 PF14634.6 EEA26726.1 - 0.018 15.0 14.5 0.14 12.1 14.7 2.5 1 1 1 2 2 2 0 zinc-RING finger domain FANCL_C PF11793.8 EEA26726.1 - 0.03 14.5 15.1 0.59 10.3 15.1 3.0 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 EEA26726.1 - 0.099 12.5 13.0 0.088 12.7 5.9 2.5 1 1 2 3 3 3 0 Prokaryotic RING finger family 4 DUF2256 PF10013.9 EEA26726.1 - 0.15 12.2 0.3 0.15 12.2 0.3 3.3 3 1 2 5 5 4 0 Uncharacterized protein conserved in bacteria (DUF2256) YacG PF03884.14 EEA26726.1 - 0.25 11.1 0.3 0.25 11.1 0.3 2.7 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf-C2H2_9 PF16293.5 EEA26726.1 - 0.44 10.4 5.3 4.7 7.1 0.0 3.1 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-HIT PF04438.16 EEA26726.1 - 0.56 10.1 8.1 0.44 10.4 3.7 2.4 2 1 0 2 2 2 0 HIT zinc finger PHD PF00628.29 EEA26726.1 - 0.79 9.7 11.9 4 7.4 11.9 2.1 1 1 0 1 1 1 0 PHD-finger TerY_C PF15616.6 EEA26726.1 - 1 9.5 6.4 1.7 8.8 6.4 1.4 1 1 0 1 1 1 0 TerY-C metal binding domain Zn_ribbon_17 PF17120.5 EEA26726.1 - 1.1 8.9 14.6 0.69 9.6 10.7 2.4 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Opy2 PF09463.10 EEA26726.1 - 1.8 8.9 9.5 1.5 9.2 5.1 2.5 2 1 1 3 3 3 0 Opy2 protein zf-RING_11 PF17123.5 EEA26726.1 - 3.4 7.5 13.3 5.7 6.8 10.5 2.6 2 1 0 2 2 2 0 RING-like zinc finger Zf_RING PF16744.5 EEA26726.1 - 3.7 7.7 8.8 1.3e+02 2.8 8.8 2.4 1 1 0 1 1 1 0 KIAA1045 RING finger zf-RING-like PF08746.11 EEA26726.1 - 3.7 7.9 11.3 20 5.6 11.3 2.1 1 1 0 1 1 1 0 RING-like domain RINGv PF12906.7 EEA26726.1 - 5.3 7.2 12.5 6.4 7.0 10.5 2.2 1 1 1 2 2 2 0 RING-variant domain Rhodanese PF00581.20 EEA26727.1 - 2.6e-18 66.5 0.0 2.2e-08 34.6 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain PIN_4 PF13638.6 EEA26728.1 - 0.0046 17.2 0.0 0.47 10.7 0.0 2.4 2 0 0 2 2 2 2 PIN domain NUDE_C PF04880.13 EEA26728.1 - 1.4 9.4 6.2 1.5 9.2 0.5 2.4 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Transp_cyt_pur PF02133.15 EEA26729.1 - 4.5e-79 266.3 39.5 5.5e-79 266.0 39.5 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sec62 PF03839.16 EEA26729.1 - 6.2 6.3 7.0 0.21 11.1 0.3 2.0 2 0 0 2 2 2 0 Translocation protein Sec62 Amdase PF17645.1 EEA26730.1 - 2.3e-16 60.1 0.1 2.8e-16 59.8 0.1 1.1 1 0 0 1 1 1 1 Arylmalonate decarboxylase DUF3802 PF12290.8 EEA26730.1 - 0.0055 17.2 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3802) Peptidase_S66 PF02016.15 EEA26730.1 - 0.13 12.4 0.1 3.4 7.8 0.0 2.4 2 1 0 2 2 2 0 LD-carboxypeptidase N-terminal domain Fungal_trans PF04082.18 EEA26731.1 - 3.7e-20 72.1 0.4 9.3e-20 70.8 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26731.1 - 0.0004 20.4 9.7 0.00068 19.7 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF412 PF04217.13 EEA26731.1 - 0.44 10.4 2.2 12 5.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF412 ADH_N PF08240.12 EEA26732.1 - 9.9e-19 67.2 1.9 1.7e-18 66.5 1.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA26732.1 - 5.9e-11 42.5 0.0 1.1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA26732.1 - 7.4e-05 22.2 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EEA26732.1 - 0.013 14.8 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain XdhC_C PF13478.6 EEA26732.1 - 0.14 12.6 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain ThiF PF00899.21 EEA26732.1 - 0.36 10.2 1.4 0.7 9.2 1.4 1.4 1 0 0 1 1 1 0 ThiF family Tyrosinase PF00264.20 EEA26733.1 - 3.4e-33 115.8 6.5 5.2e-33 115.2 6.5 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase KRAB PF01352.27 EEA26733.1 - 1.6 8.4 4.0 17 5.2 0.1 3.2 3 0 0 3 3 3 0 KRAB box GFA PF04828.14 EEA26734.1 - 5.7e-23 81.1 0.2 9e-23 80.4 0.2 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.11 EEA26734.1 - 0.065 13.4 1.6 0.82 9.9 0.0 2.3 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Auto_anti-p27 PF06677.12 EEA26734.1 - 0.098 12.8 0.1 0.098 12.8 0.1 1.7 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) GMC_oxred_N PF00732.19 EEA26735.1 - 8.1e-50 169.9 0.0 1.3e-49 169.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA26735.1 - 1.9e-39 135.4 0.0 3.2e-39 134.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EEA26735.1 - 4.5e-06 26.0 0.3 0.0088 15.2 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EEA26735.1 - 2.9e-05 23.8 0.2 8.9e-05 22.2 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA26735.1 - 0.00067 19.0 0.3 0.0017 17.7 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA26735.1 - 0.0012 18.0 0.1 0.0023 17.1 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EEA26735.1 - 0.0026 17.1 0.1 0.051 12.8 0.3 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA26735.1 - 0.0055 16.9 0.1 0.014 15.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA26735.1 - 0.06 12.6 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EEA26735.1 - 0.088 11.5 0.2 0.14 10.9 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Fungal_trans PF04082.18 EEA26736.1 - 1.8e-23 83.0 0.1 3.4e-23 82.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26736.1 - 8.7e-08 32.2 13.1 1.6e-07 31.3 13.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_4 PF07993.12 EEA26737.1 - 7.6e-31 107.2 0.0 1.6e-30 106.1 0.0 1.6 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 EEA26737.1 - 2.3e-20 72.6 0.0 4e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EEA26737.1 - 2.4e-11 43.6 0.0 4.1e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA26737.1 - 0.0001 22.6 0.1 0.00033 20.9 0.1 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 EEA26737.1 - 0.00021 21.2 0.0 0.001 19.1 0.0 2.0 1 1 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EEA26737.1 - 0.087 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase IPT PF01745.16 EEA26737.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Isopentenyl transferase Polysacc_synt_2 PF02719.15 EEA26737.1 - 0.18 10.9 0.0 0.47 9.5 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA26737.1 - 0.2 10.7 0.0 26 3.8 0.0 2.8 3 0 0 3 3 3 0 RmlD substrate binding domain Aldo_ket_red PF00248.21 EEA26738.1 - 1.4e-73 247.7 0.0 1.6e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HAMP_N3 PF18575.1 EEA26738.1 - 0.14 11.7 0.1 0.52 9.9 0.0 2.0 2 0 0 2 2 2 0 HAMP N-terminal domain 3 NAD_binding_4 PF07993.12 EEA26739.1 - 7.4e-35 120.3 0.0 1.3e-34 119.5 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EEA26739.1 - 5.7e-34 117.4 0.1 8.4e-34 116.9 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EEA26739.1 - 3.3e-11 43.1 0.0 1.7e-10 40.8 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA26739.1 - 6.5e-08 32.8 0.0 1.5e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site NmrA PF05368.13 EEA26739.1 - 0.0039 16.8 0.0 0.0078 15.8 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EEA26739.1 - 0.061 12.4 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA26739.1 - 0.082 12.0 0.0 2.4 7.2 0.0 2.7 3 0 0 3 3 3 0 RmlD substrate binding domain MFS_1 PF07690.16 EEA26740.1 - 1.5e-42 145.8 49.0 6.5e-41 140.4 49.0 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA26740.1 - 5.8e-15 54.7 25.1 8.5e-15 54.2 25.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EEA26740.1 - 0.25 9.6 12.9 0.031 12.6 1.9 2.9 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family RPEL PF02755.15 EEA26741.1 - 9.2e-24 82.4 20.9 2.2e-08 33.5 2.5 3.6 3 0 0 3 3 3 3 RPEL repeat CP12 PF02672.15 EEA26741.1 - 0.02 15.7 3.3 1.3 9.8 0.1 3.0 3 0 0 3 3 3 0 CP12 domain RPEL PF02755.15 EEA26742.1 - 9.2e-24 82.4 20.9 2.2e-08 33.5 2.5 3.6 3 0 0 3 3 3 3 RPEL repeat CP12 PF02672.15 EEA26742.1 - 0.02 15.7 3.3 1.3 9.8 0.1 3.0 3 0 0 3 3 3 0 CP12 domain Translin PF01997.16 EEA26743.1 - 5.8e-73 245.2 0.0 7.2e-73 244.9 0.0 1.1 1 0 0 1 1 1 1 Translin family DUF3450 PF11932.8 EEA26743.1 - 0.034 13.4 0.0 0.16 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Peptidase_A4 PF01828.17 EEA26744.1 - 4.6e-76 254.9 13.5 5.5e-76 254.7 13.5 1.1 1 0 0 1 1 1 1 Peptidase A4 family DnaJ-X PF14308.6 EEA26745.1 - 1.6e-77 259.8 2.3 1.6e-77 259.8 2.3 3.0 3 1 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.31 EEA26745.1 - 6.1e-25 87.1 0.2 1.8e-24 85.7 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain OrfB_IS605 PF01385.19 EEA26745.1 - 0.97 9.7 4.3 1.4 9.2 2.1 2.3 2 0 0 2 2 2 0 Probable transposase SQS_PSY PF00494.19 EEA26746.1 - 1.8e-37 129.3 0.0 2.3e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Synaptobrevin PF00957.21 EEA26746.1 - 8.6e-05 22.3 0.8 0.033 14.0 0.2 2.7 3 0 0 3 3 3 2 Synaptobrevin DUF5383 PF17355.2 EEA26746.1 - 0.037 14.4 0.2 0.32 11.4 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5383) Hemerythrin PF01814.23 EEA26747.1 - 3.7e-10 40.5 1.3 5.6e-10 39.9 1.3 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain IMS PF00817.20 EEA26748.1 - 7.3e-44 149.4 0.3 1.3e-43 148.6 0.3 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EEA26748.1 - 2e-15 57.6 0.1 4.7e-15 56.3 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EEA26748.1 - 1.7e-06 28.0 0.0 4e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif NIBRIN_BRCT_II PF16508.5 EEA26750.1 - 1.6e-37 128.4 0.1 7.2e-37 126.3 0.0 2.2 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 EEA26750.1 - 1.5e-07 31.6 0.4 3.9e-07 30.3 0.4 1.7 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.5 EEA26750.1 - 0.031 14.2 0.0 0.084 12.8 0.0 1.7 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Yop-YscD_cpl PF16697.5 EEA26750.1 - 0.055 13.8 0.2 0.65 10.3 0.2 2.5 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Glyco_hydro_53 PF07745.13 EEA26750.1 - 0.12 11.4 0.1 5.1 6.0 0.1 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 53 F-box-like PF12937.7 EEA26751.1 - 0.036 14.0 0.0 0.12 12.3 0.0 2.0 1 1 0 1 1 1 0 F-box-like Mannosyl_trans PF05007.13 EEA26752.1 - 1.8e-75 254.2 17.7 2.7e-75 253.6 17.7 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EEA26752.1 - 5.8e-12 45.4 6.9 5.8e-12 45.4 6.9 2.2 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EEA26752.1 - 0.0026 17.5 11.9 0.0026 17.5 11.9 2.8 1 1 1 3 3 3 1 Glycosyltransferase family 87 DUF4238 PF14022.6 EEA26755.1 - 1.5e-60 205.1 0.0 2.3e-60 204.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4238) FAD_binding_3 PF01494.19 EEA26756.1 - 3.2e-14 52.9 0.0 6e-14 52.1 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA26756.1 - 0.00068 19.3 0.1 0.0021 17.7 0.0 1.8 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA26756.1 - 0.00093 19.4 0.0 0.0031 17.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA26756.1 - 0.0012 18.0 0.6 0.0029 16.7 0.6 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA26756.1 - 0.0024 17.1 0.0 0.022 14.0 0.0 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA26756.1 - 0.0026 17.1 0.0 0.0042 16.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 EEA26756.1 - 0.0083 15.0 0.0 0.023 13.5 0.0 1.7 2 0 0 2 2 2 1 Tryptophan halogenase Dabb PF07876.12 EEA26757.1 - 2.1e-19 69.9 0.0 5e-19 68.7 0.0 1.7 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain HSP20 PF00011.21 EEA26757.1 - 4.2e-18 65.4 0.0 1.2e-13 51.0 0.0 2.4 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EEA26757.1 - 7.4e-05 22.2 0.0 0.018 14.6 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA Ig_GlcNase PF18368.1 EEA26758.1 - 5.1e-32 110.2 0.1 1.3e-31 108.8 0.1 1.8 1 0 0 1 1 1 1 Exo-beta-D-glucosaminidase Ig-fold domain Glyco_hydro_2 PF00703.21 EEA26758.1 - 2.1e-08 34.8 0.4 4.7e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EEA26758.1 - 1.7e-06 28.0 0.0 4.2e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Mannosidase_ig PF17786.1 EEA26758.1 - 0.00036 21.1 0.4 0.0022 18.6 0.0 2.5 3 0 0 3 3 3 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_C PF02836.17 EEA26758.1 - 0.031 13.4 0.3 0.053 12.6 0.3 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Ig_mannosidase PF17753.1 EEA26758.1 - 0.079 12.7 0.8 0.33 10.7 0.1 2.5 3 0 0 3 3 3 0 Ig-fold domain zf-RING_UBOX PF13445.6 EEA26759.1 - 4.5e-08 33.0 4.3 4.5e-08 33.0 4.3 3.6 4 0 0 4 4 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA26759.1 - 4.5e-08 32.8 3.9 4.5e-08 32.8 3.9 4.2 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA26759.1 - 3.6e-07 29.9 2.5 3.6e-07 29.9 2.5 4.3 5 1 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA26759.1 - 1.8e-06 27.8 3.4 1.8e-06 27.8 3.4 5.0 4 2 0 4 4 3 1 zinc-RING finger domain SH3_9 PF14604.6 EEA26759.1 - 2.7e-06 27.2 0.1 7.8e-06 25.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain zf-RING_2 PF13639.6 EEA26759.1 - 2.8e-06 27.6 5.9 2.8e-06 27.6 5.9 4.3 4 0 0 4 4 2 1 Ring finger domain zf-RING_6 PF14835.6 EEA26759.1 - 7.6e-06 25.7 0.7 7.6e-06 25.7 0.7 3.0 3 0 0 3 3 2 1 zf-RING of BARD1-type protein SH3_1 PF00018.28 EEA26759.1 - 0.00012 21.6 0.1 0.00027 20.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain zf-C3HC4_4 PF15227.6 EEA26759.1 - 0.00016 21.8 6.0 0.00016 21.8 6.0 4.4 5 0 0 5 5 5 1 zinc finger of C3HC4-type, RING SH3_2 PF07653.17 EEA26759.1 - 0.0004 20.0 0.0 0.0024 17.5 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain CpXC PF14353.6 EEA26759.1 - 0.15 12.2 2.7 0.22 11.6 0.0 2.6 3 0 0 3 3 2 0 CpXC protein Annexin PF00191.20 EEA26760.1 - 1.4e-62 207.6 0.4 1.7e-16 60.0 0.0 4.1 4 0 0 4 4 4 4 Annexin DUF5638 PF18688.1 EEA26760.1 - 0.00015 22.0 0.0 0.1 12.9 0.0 2.4 2 0 0 2 2 2 2 Family of unknown function (DUF5638) DUF1645 PF07816.11 EEA26760.1 - 0.008 16.8 0.0 0.013 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) DUF445 PF04286.12 EEA26760.1 - 0.027 14.3 0.2 0.043 13.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Acetyltransf_11 PF13720.6 EEA26760.1 - 0.076 13.5 0.3 22 5.6 0.1 2.7 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF515 PF04415.12 EEA26760.1 - 0.18 10.2 0.1 0.51 8.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF515) YpjP PF14005.6 EEA26760.1 - 0.26 11.3 4.1 1.3 9.0 1.3 2.2 1 1 1 2 2 2 0 YpjP-like protein EBP PF05241.12 EEA26761.1 - 4e-65 218.6 3.6 4.8e-65 218.3 3.6 1.0 1 0 0 1 1 1 1 Emopamil binding protein IFT57 PF10498.9 EEA26763.1 - 0.056 12.4 35.4 0.031 13.2 8.4 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Cnn_1N PF07989.11 EEA26763.1 - 0.17 12.1 0.1 0.17 12.1 0.1 4.4 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 FUSC PF04632.12 EEA26763.1 - 0.3 9.6 3.8 0.53 8.8 3.8 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family BST2 PF16716.5 EEA26763.1 - 0.32 11.6 0.0 0.32 11.6 0.0 4.5 2 1 1 4 4 4 0 Bone marrow stromal antigen 2 DUF812 PF05667.11 EEA26763.1 - 0.49 9.2 32.9 0.8 8.5 32.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Leu_zip PF15294.6 EEA26763.1 - 0.57 9.6 31.4 0.065 12.7 4.1 2.6 1 1 1 2 2 2 0 Leucine zipper DUF3959 PF13105.6 EEA26763.1 - 1 8.8 3.3 2.1 7.8 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) YedD PF13987.6 EEA26763.1 - 1.2 9.0 3.8 20 5.0 0.9 3.3 3 0 0 3 3 3 0 YedD-like protein GST_C_3 PF14497.6 EEA26764.1 - 3e-19 69.0 0.1 5.6e-19 68.2 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA26764.1 - 4.7e-08 33.3 0.0 9.7e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA26764.1 - 6e-06 26.2 0.0 1.2e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA26764.1 - 0.00022 21.4 0.1 0.00076 19.7 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA26764.1 - 0.093 13.0 0.0 0.38 11.1 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA26764.1 - 0.1 13.0 0.0 0.41 11.1 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain DUF1223 PF06764.11 EEA26766.1 - 1.7e-51 175.1 0.3 2e-51 174.9 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1223) ComGF PF15980.5 EEA26766.1 - 0.06 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative Competence protein ComGF Thioredoxin_3 PF13192.6 EEA26766.1 - 0.066 13.3 0.5 3.7 7.7 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain IRF-2BP1_2 PF11261.8 EEA26766.1 - 0.2 11.3 0.7 16 5.2 0.1 2.4 2 0 0 2 2 2 0 Interferon regulatory factor 2-binding protein zinc finger Transferase PF02458.15 EEA26767.1 - 1.2e-21 76.9 0.0 1.1e-20 73.7 0.0 2.3 1 1 0 1 1 1 1 Transferase family Fungal_trans PF04082.18 EEA26768.1 - 1.2e-05 24.5 2.3 2.5e-05 23.5 0.1 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26768.1 - 0.00013 22.0 8.2 0.00025 21.1 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CD225 PF04505.12 EEA26768.1 - 0.061 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Interferon-induced transmembrane protein Transp_cyt_pur PF02133.15 EEA26771.1 - 2.9e-90 303.2 42.5 3.8e-90 302.8 42.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin HPP PF04982.13 EEA26771.1 - 0.027 14.6 8.2 0.13 12.5 3.0 3.1 2 0 0 2 2 2 0 HPP family DIOX_N PF14226.6 EEA26772.1 - 6.1e-28 98.0 0.0 8.6e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA26772.1 - 1.4e-23 83.3 0.0 2.3e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily L31 PF09784.9 EEA26775.1 - 7.2e-44 148.4 0.4 8e-44 148.2 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Acyltransferase PF01553.21 EEA26776.1 - 4.4e-12 45.8 0.0 9.7e-12 44.7 0.0 1.6 1 1 0 1 1 1 1 Acyltransferase DEAD PF00270.29 EEA26777.1 - 7.5e-41 139.8 0.3 1.5e-40 138.9 0.3 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA26777.1 - 4.6e-31 107.4 0.6 1.3e-30 105.9 0.1 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA26777.1 - 1.3e-05 25.3 0.4 3.4e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TLP-20 PF06088.11 EEA26777.1 - 0.011 15.6 1.1 0.019 14.8 1.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CDC45 PF02724.14 EEA26777.1 - 0.021 13.1 0.4 0.032 12.5 0.4 1.2 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 EEA26777.1 - 0.77 9.4 9.7 0.41 10.3 2.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 PTRF_SDPR PF15237.6 EEA26777.1 - 0.89 9.1 9.6 0.069 12.8 4.1 1.9 2 0 0 2 2 2 0 PTRF/SDPR family DUF1383 PF07134.11 EEA26778.1 - 0.22 10.6 0.0 0.3 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1383) Carbam_trans_N PF02543.15 EEA26779.1 - 0.077 12.6 0.4 11 5.5 0.0 2.2 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus AAA_11 PF13086.6 EEA26781.1 - 7e-65 219.4 0.5 2e-64 217.9 0.4 1.9 2 0 0 2 2 1 1 AAA domain AAA_12 PF13087.6 EEA26781.1 - 1.9e-58 197.4 0.0 4.2e-58 196.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA26781.1 - 8.9e-13 48.4 0.0 2.5e-11 43.7 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA26781.1 - 8.1e-09 36.0 0.0 3.3e-08 34.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EEA26781.1 - 2.4e-07 30.3 0.5 1.4e-06 27.8 0.5 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 EEA26781.1 - 5.4e-07 29.6 0.0 0.35 10.6 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EEA26781.1 - 4.5e-06 26.8 0.0 2.2e-05 24.5 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EEA26781.1 - 2.9e-05 23.8 0.7 7.7e-05 22.4 0.6 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 EEA26781.1 - 6.7e-05 23.2 0.2 0.0019 18.5 0.2 2.6 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 EEA26781.1 - 0.00012 21.6 0.0 0.0018 17.7 0.0 2.3 1 1 0 1 1 1 1 PhoH-like protein Helicase_RecD PF05127.14 EEA26781.1 - 0.00082 19.3 0.0 0.23 11.3 0.0 2.6 2 0 0 2 2 2 1 Helicase Flavi_DEAD PF07652.14 EEA26781.1 - 0.001 19.0 0.1 0.0066 16.4 0.1 2.1 2 0 0 2 2 2 1 Flavivirus DEAD domain AAA_16 PF13191.6 EEA26781.1 - 0.0013 19.1 0.0 0.0031 17.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 EEA26781.1 - 0.0015 17.7 0.0 0.0039 16.3 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 EEA26781.1 - 0.0072 15.9 0.0 0.098 12.2 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA PF00004.29 EEA26781.1 - 0.016 15.6 0.3 0.079 13.4 0.1 2.3 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EEA26781.1 - 0.022 14.5 0.0 0.068 12.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA26781.1 - 0.023 14.4 0.0 0.067 12.9 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein UvrD_C PF13361.6 EEA26781.1 - 0.027 13.9 0.0 6.6 6.0 0.0 3.0 3 0 0 3 3 3 0 UvrD-like helicase C-terminal domain TrwB_AAD_bind PF10412.9 EEA26781.1 - 0.027 13.4 0.0 0.062 12.2 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_10 PF12846.7 EEA26781.1 - 0.029 13.3 0.0 0.051 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain 4HB_MCP_1 PF12729.7 EEA26781.1 - 0.051 13.1 0.1 0.051 13.1 0.1 1.7 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction AAA_23 PF13476.6 EEA26781.1 - 0.053 14.0 3.1 1.7 9.1 0.0 2.9 3 0 0 3 3 2 0 AAA domain DUF241 PF03087.14 EEA26781.1 - 0.065 13.1 0.3 0.16 11.8 0.3 1.6 1 0 0 1 1 1 0 Arabidopsis protein of unknown function TK PF00265.18 EEA26781.1 - 0.071 13.0 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 Thymidine kinase UvrD_C_2 PF13538.6 EEA26781.1 - 0.075 12.9 0.0 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain ABC_tran PF00005.27 EEA26781.1 - 0.075 13.5 0.1 0.21 12.1 0.1 1.9 1 1 0 1 1 1 0 ABC transporter cobW PF02492.19 EEA26781.1 - 0.1 12.2 0.0 0.4 10.2 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 EEA26781.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PIF1 PF05970.14 EEA26781.1 - 0.13 11.4 0.0 2.6 7.1 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase AAA_5 PF07728.14 EEA26781.1 - 0.13 12.3 0.0 0.54 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) HhH-GPD PF00730.25 EEA26782.1 - 6.9e-19 68.3 0.0 2.1e-18 66.8 0.0 1.9 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EEA26782.1 - 9.6e-10 37.8 0.0 3.3e-09 36.2 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EEA26782.1 - 0.083 13.5 0.0 0.38 11.4 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain UQ_con PF00179.26 EEA26783.1 - 2.1e-41 140.8 0.0 2.4e-41 140.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA26783.1 - 0.00019 21.2 0.0 0.0004 20.1 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 EEA26783.1 - 0.0078 15.9 0.0 0.0096 15.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 DUF3435 PF11917.8 EEA26785.1 - 2.4e-50 171.7 1.9 4.6e-34 118.1 0.0 3.4 2 1 2 4 4 4 3 Protein of unknown function (DUF3435) EarP PF10093.9 EEA26785.1 - 0.12 11.4 0.0 1.1 8.3 0.0 2.3 3 0 0 3 3 3 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP TspO_MBR PF03073.15 EEA26786.1 - 4e-44 149.9 8.4 4.9e-44 149.7 8.4 1.1 1 0 0 1 1 1 1 TspO/MBR family Imp-YgjV PF10688.9 EEA26786.1 - 0.47 10.3 4.4 0.18 11.6 1.6 1.8 2 0 0 2 2 2 0 Bacterial inner membrane protein Glyco_hydro_18 PF00704.28 EEA26787.1 - 1.7e-83 281.0 4.1 2.1e-83 280.6 4.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Aim21 PF11489.8 EEA26789.1 - 6.4e-213 709.7 64.0 6.4e-213 709.7 64.0 1.5 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 Cg6151-P PF10233.9 EEA26790.1 - 5.2e-42 142.7 11.3 6.1e-42 142.5 11.3 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P CitMHS PF03600.16 EEA26790.1 - 0.027 13.7 5.7 0.028 13.6 5.7 1.1 1 0 0 1 1 1 0 Citrate transporter Goodbye PF17109.5 EEA26790.1 - 0.033 14.6 0.7 0.056 13.9 0.5 1.4 1 1 0 1 1 1 0 fungal STAND N-terminal Goodbye domain DUF5489 PF17592.2 EEA26790.1 - 0.11 13.1 3.6 1.7 9.2 0.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5489) Phage_holin_3_6 PF07332.11 EEA26790.1 - 0.11 12.6 8.8 0.17 12.0 2.2 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3169 PF11368.8 EEA26790.1 - 0.62 9.5 8.7 0.2 11.1 4.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DUF202 PF02656.15 EEA26790.1 - 0.88 10.1 9.9 4.4 7.8 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF2721 PF11026.8 EEA26790.1 - 1.4 8.8 11.8 4 7.3 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF3040 PF11239.8 EEA26790.1 - 3 8.2 8.3 15 5.9 3.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) DUF3784 PF12650.7 EEA26790.1 - 3.3 8.0 10.1 0.75 10.0 2.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) DUF2518 PF10726.9 EEA26790.1 - 3.6 7.2 5.6 12 5.5 0.9 2.1 2 0 0 2 2 2 0 Protein of function (DUF2518) PRA1 PF03208.19 EEA26790.1 - 7.1 6.3 9.3 42 3.7 9.7 1.9 1 1 0 1 1 1 0 PRA1 family protein NTF2 PF02136.20 EEA26791.1 - 1e-32 113.2 0.2 1.1e-32 113.1 0.2 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 EEA26791.1 - 0.14 12.6 0.0 0.17 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) NTF2 PF02136.20 EEA26792.1 - 1.1e-20 74.4 0.0 1.2e-20 74.3 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Surp PF01805.20 EEA26793.1 - 9.6e-09 35.1 0.0 1.7e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Surp module Abhydrolase_6 PF12697.7 EEA26794.1 - 3.9e-11 44.0 0.0 5e-11 43.6 0.0 1.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EEA26794.1 - 2.1e-06 27.6 0.1 3e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 EEA26794.1 - 4e-05 23.4 0.4 7.9e-05 22.4 0.4 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EEA26794.1 - 0.00012 21.9 0.1 0.00019 21.3 0.1 1.2 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 EEA26794.1 - 0.0024 17.2 0.2 0.0097 15.2 0.3 2.0 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EEA26794.1 - 0.0074 16.2 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EEA26794.1 - 0.042 13.7 0.2 0.08 12.7 0.2 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 EEA26794.1 - 0.045 13.9 0.0 0.069 13.3 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.25 EEA26794.1 - 0.061 13.2 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) TFIIB PF00382.19 EEA26795.1 - 1.3e-33 114.9 0.0 1e-18 67.2 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EEA26795.1 - 4.2e-10 39.0 0.9 9.1e-10 37.9 0.9 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding RB_B PF01857.20 EEA26795.1 - 0.00019 21.4 0.0 0.0015 18.6 0.1 2.0 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain HTH_5 PF01022.20 EEA26795.1 - 0.0089 15.9 0.0 2.3 8.2 0.0 2.6 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family Cyclin_C PF02984.19 EEA26795.1 - 0.011 15.9 0.0 3.7 7.7 0.0 2.4 2 1 0 2 2 2 0 Cyclin, C-terminal domain Sigma70_r4 PF04545.16 EEA26795.1 - 0.13 11.8 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 EEA26795.1 - 0.13 11.7 0.0 0.51 9.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 DUF1610 PF07754.11 EEA26795.1 - 0.22 11.5 2.6 1.1 9.2 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-ribbon_3 PF13248.6 EEA26795.1 - 0.42 10.1 5.8 6.6 6.3 0.3 2.8 3 0 0 3 3 3 0 zinc-ribbon domain ATP_sub_h PF10775.9 EEA26796.1 - 4.7e-26 90.6 1.1 6.3e-26 90.2 1.1 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.11 EEA26796.1 - 0.0002 21.7 0.0 0.00033 21.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 DUF1765 PF08578.10 EEA26798.1 - 1.4e-39 135.4 10.7 3.3e-39 134.2 10.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) MFS_1 PF07690.16 EEA26799.1 - 5.6e-16 58.4 16.7 5.6e-16 58.4 16.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily RseC_MucC PF04246.12 EEA26799.1 - 0.32 10.9 2.5 0.5 10.3 1.3 2.0 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF2530 PF10745.9 EEA26799.1 - 1.9 8.7 5.5 0.65 10.3 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2530) SPC25 PF06703.11 EEA26800.1 - 0.69 9.7 3.2 6.5 6.5 2.1 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) TFR_dimer PF04253.15 EEA26802.1 - 1.1e-36 125.6 0.0 2.1e-36 124.7 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EEA26802.1 - 5.3e-19 68.7 0.0 1.5e-18 67.2 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EEA26802.1 - 5.3e-16 58.4 0.1 1.1e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 EEA26802.1 - 0.097 12.1 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Nicastrin HMG_CoA_synt_C PF08540.10 EEA26803.1 - 1.7e-106 355.9 1.4 2.3e-106 355.5 1.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EEA26803.1 - 1.4e-98 327.9 0.2 2.6e-98 327.0 0.2 1.5 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 EEA26804.1 - 1.7e-106 355.9 1.4 2.3e-106 355.5 1.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EEA26804.1 - 1.4e-98 327.9 0.2 2.6e-98 327.0 0.2 1.5 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 EEA26805.1 - 1.7e-106 355.9 1.4 2.3e-106 355.5 1.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EEA26805.1 - 1.4e-98 327.9 0.2 2.6e-98 327.0 0.2 1.5 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Glyco_hydro_64 PF16483.5 EEA26807.1 - 1.2e-126 423.0 3.9 1.4e-126 422.7 3.9 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase K_oxygenase PF13434.6 EEA26808.1 - 2.6e-17 63.0 0.0 5.1e-10 39.0 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EEA26808.1 - 1.3e-07 31.2 0.0 0.0041 16.4 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA26808.1 - 4.8e-07 29.3 0.0 0.0085 15.4 0.0 3.3 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA26808.1 - 1.2e-06 28.7 0.2 0.013 15.5 0.0 3.0 2 1 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 EEA26808.1 - 0.00048 19.8 5.1 0.0012 18.5 0.4 3.3 3 1 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA26808.1 - 0.0031 16.3 0.0 0.2 10.3 0.0 2.3 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EEA26808.1 - 0.0032 16.6 0.2 0.011 14.8 0.0 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein GIDA PF01134.22 EEA26808.1 - 0.0035 16.5 0.1 0.12 11.5 0.1 2.4 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EEA26808.1 - 0.0071 16.6 0.5 0.13 12.5 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA26808.1 - 0.022 14.0 0.1 0.05 12.8 0.0 1.6 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 EEA26808.1 - 0.023 14.0 0.3 0.18 11.0 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 EEA26808.1 - 0.085 13.4 0.6 14 6.3 0.1 2.8 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA26808.1 - 0.097 11.7 0.0 0.3 10.1 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Amino_oxidase PF01593.24 EEA26808.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.6 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase K_oxygenase PF13434.6 EEA26809.1 - 2.4e-16 59.8 0.0 1.7e-08 34.0 0.0 3.7 4 0 0 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EEA26809.1 - 2.5e-07 30.2 0.0 0.012 14.9 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA26809.1 - 6e-07 29.0 0.0 0.0089 15.3 0.0 3.3 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA26809.1 - 1.3e-06 28.5 0.2 0.014 15.4 0.0 2.9 2 1 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 EEA26809.1 - 0.00032 20.4 4.2 0.0013 18.4 0.4 3.2 3 1 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA26809.1 - 0.0034 16.1 0.0 0.21 10.3 0.0 2.3 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EEA26809.1 - 0.0035 16.4 0.2 0.011 14.8 0.0 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein GIDA PF01134.22 EEA26809.1 - 0.0039 16.3 0.1 0.12 11.4 0.1 2.4 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EEA26809.1 - 0.0077 16.4 0.5 0.14 12.4 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA26809.1 - 0.023 14.0 0.1 0.052 12.8 0.0 1.6 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 EEA26809.1 - 0.025 13.8 0.3 0.19 10.9 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain FAD_binding_2 PF00890.24 EEA26809.1 - 0.11 11.6 0.0 0.31 10.0 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 EEA26809.1 - 0.13 12.9 1.0 17 6.1 0.2 2.8 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase GFO_IDH_MocA PF01408.22 EEA26810.1 - 3.6e-10 40.7 0.0 7.8e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EEA26810.1 - 6.6e-05 22.9 0.0 0.00015 21.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Stimulus_sens_1 PF13756.6 EEA26810.1 - 0.088 13.4 0.0 0.2 12.3 0.0 1.7 1 0 0 1 1 1 0 Stimulus-sensing domain PGM_PMM_I PF02878.16 EEA26811.1 - 2.1e-33 114.9 0.0 3.2e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EEA26811.1 - 1.8e-25 89.3 0.0 3.2e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EEA26811.1 - 2.1e-17 63.6 0.1 4.6e-17 62.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EEA26811.1 - 9.1e-09 35.4 0.0 2.1e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RNase_T PF00929.24 EEA26812.1 - 2.3e-26 93.3 0.0 2.6e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Exonuclease Sugar_tr PF00083.24 EEA26813.1 - 2.7e-85 286.9 20.3 3.4e-85 286.6 20.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA26813.1 - 1.8e-12 46.9 45.7 1.2e-07 31.0 12.0 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF4293 PF14126.6 EEA26813.1 - 0.82 9.9 6.2 0.73 10.1 2.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) Glyco_hydro_3 PF00933.21 EEA26815.1 - 1.9e-89 300.2 0.0 2.7e-89 299.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 EEA26815.1 - 2.5e-17 63.2 0.0 5.2e-09 36.3 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA26815.1 - 6.1e-13 48.8 0.0 2.3e-06 27.5 0.0 2.9 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA26815.1 - 2.5e-12 47.0 0.0 4e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA26815.1 - 8.7e-09 35.5 0.0 0.001 19.1 0.0 2.7 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA26815.1 - 0.0018 18.2 0.0 0.072 13.1 0.0 2.5 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 EEA26815.1 - 0.0026 18.5 0.0 0.049 14.3 0.0 2.8 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EEA26815.1 - 0.0035 17.3 0.0 0.14 12.1 0.0 2.5 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase Acetyltransf_CG PF14542.6 EEA26815.1 - 0.0063 16.6 0.2 3.2 8.0 0.0 2.6 2 0 0 2 2 2 2 GCN5-related N-acetyl-transferase Glyco_hydro_3_C PF01915.22 EEA26815.1 - 0.0072 16.3 0.0 0.018 15.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_6 PF13480.7 EEA26815.1 - 0.11 12.7 0.0 0.42 10.8 0.0 2.0 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 EEA26816.1 - 2.2e-26 92.7 25.5 2.2e-26 92.7 25.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Cytochrome-c551 PF10643.9 EEA26816.1 - 0.055 13.1 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 Fungal_trans_2 PF11951.8 EEA26817.1 - 3.7e-09 35.9 0.1 7.7e-08 31.5 0.1 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26817.1 - 3.7e-07 30.1 6.1 1.2e-06 28.5 6.1 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidase PF01425.21 EEA26818.1 - 4.5e-99 332.4 0.0 2.2e-98 330.2 0.0 1.8 1 1 0 1 1 1 1 Amidase DDE_1 PF03184.19 EEA26820.1 - 4.9e-24 84.9 0.0 9.9e-24 83.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA26820.1 - 8.9e-09 35.3 0.3 3.1e-08 33.5 0.3 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA26820.1 - 0.026 14.6 0.1 0.53 10.5 0.0 2.7 3 0 0 3 3 3 0 Transcription factor Pcc1 Amidase PF01425.21 EEA26820.1 - 0.054 12.4 1.6 0.083 11.8 1.6 1.2 1 0 0 1 1 1 0 Amidase Sel1 PF08238.12 EEA26821.1 - 2.9e-43 145.3 31.1 5.6e-07 30.0 0.5 7.5 7 0 0 7 7 7 7 Sel1 repeat PI3K_C2 PF00792.24 EEA26821.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 ANAPC3 PF12895.7 EEA26821.1 - 0.22 11.8 3.6 2 8.7 0.1 3.5 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 CBP4 PF07960.11 EEA26822.1 - 3.9e-30 104.4 3.8 5.4e-30 103.9 3.8 1.2 1 0 0 1 1 1 1 CBP4 Ku_PK_bind PF08785.11 EEA26822.1 - 0.0075 16.4 3.3 0.068 13.3 2.8 2.0 1 1 1 2 2 2 2 Ku C terminal domain like COG6 PF06419.11 EEA26824.1 - 0.0064 14.8 2.4 0.0096 14.2 2.4 1.2 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DUF1664 PF07889.12 EEA26824.1 - 0.024 14.7 1.5 0.024 14.7 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EEA26824.1 - 0.026 14.8 2.2 1.3 9.4 1.0 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) YkyA PF10368.9 EEA26824.1 - 0.047 13.4 0.3 0.18 11.5 0.1 1.9 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein HrpB7 PF09486.10 EEA26824.1 - 0.91 9.9 9.3 0.41 11.0 1.7 3.2 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) Fib_alpha PF08702.10 EEA26824.1 - 1.7 8.8 6.2 0.89 9.7 2.6 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family MPC PF03650.13 EEA26825.1 - 5.4e-49 164.9 1.0 7.6e-49 164.4 1.0 1.2 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers L51_S25_CI-B8 PF05047.16 EEA26826.1 - 1.4e-13 50.5 0.0 1.8e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain L51_S25_CI-B8 PF05047.16 EEA26827.1 - 9.2e-11 41.5 0.1 1.3e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain HATPase_c PF02518.26 EEA26828.1 - 7.3e-28 97.3 0.1 1.3e-26 93.3 0.0 2.9 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EEA26828.1 - 1.3e-25 89.7 0.4 5.2e-25 87.8 0.4 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EEA26828.1 - 1e-14 54.3 0.0 2.3e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EEA26828.1 - 0.0044 17.4 0.7 0.35 11.3 0.3 2.6 2 0 0 2 2 2 1 HAMP domain Glyco_hydro_3_C PF01915.22 EEA26829.1 - 8.4e-42 143.4 0.0 3.2e-41 141.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA26829.1 - 3.1e-39 135.2 0.0 4.8e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA26829.1 - 1.9e-24 85.5 0.1 3.5e-24 84.7 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain ABC_tran PF00005.27 EEA26830.1 - 1.4e-48 164.9 0.3 1.7e-24 86.9 0.0 4.2 2 2 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EEA26830.1 - 1.2e-13 51.0 0.1 0.00042 19.8 0.0 3.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA26830.1 - 1.7e-13 51.1 6.8 0.00011 22.1 0.0 4.5 4 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA26830.1 - 7e-09 36.5 0.1 0.0004 21.0 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EEA26830.1 - 9e-07 28.5 1.3 0.0087 15.8 0.4 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EEA26830.1 - 1.9e-06 27.9 0.1 0.015 15.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EEA26830.1 - 6.7e-06 26.2 0.0 0.096 12.8 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase Chromo PF00385.24 EEA26830.1 - 7.3e-06 25.8 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_15 PF13175.6 EEA26830.1 - 4.2e-05 23.4 0.7 0.033 13.9 0.7 2.4 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 EEA26830.1 - 0.00051 20.2 0.9 0.21 11.7 0.1 3.3 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_22 PF13401.6 EEA26830.1 - 0.00055 20.2 0.1 0.45 10.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EEA26830.1 - 0.0011 19.3 0.0 0.6 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain DNA_ligase_OB_2 PF14743.6 EEA26830.1 - 0.0011 18.9 0.1 0.0036 17.3 0.1 1.8 1 0 0 1 1 1 1 DNA ligase OB-like domain SbcCD_C PF13558.6 EEA26830.1 - 0.0036 17.5 0.1 1.7 8.9 0.0 3.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 EEA26830.1 - 0.015 15.2 0.2 1.2 9.0 0.0 2.7 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 EEA26830.1 - 0.022 14.5 0.7 7.8 6.2 0.2 3.0 3 0 0 3 3 2 0 AAA domain AAA_13 PF13166.6 EEA26830.1 - 0.023 13.4 0.0 2.4 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EEA26830.1 - 0.024 14.8 0.0 6.1 7.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EEA26830.1 - 0.026 14.9 0.1 4.9 7.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 EEA26830.1 - 0.046 13.5 1.0 2.5 7.8 0.2 2.5 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EEA26830.1 - 0.048 13.7 0.0 1.2 9.2 0.0 2.8 2 1 0 2 2 2 0 Dynamin family MukB PF04310.12 EEA26830.1 - 0.054 13.3 0.3 8.2 6.2 0.0 2.6 2 0 0 2 2 2 0 MukB N-terminal SR-25 PF10500.9 EEA26830.1 - 0.076 12.6 1.5 0.15 11.7 1.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ALF PF03752.13 EEA26830.1 - 0.076 13.0 7.5 1.1 9.3 1.2 3.0 3 0 0 3 3 2 0 Short repeats of unknown function AAA_18 PF13238.6 EEA26830.1 - 0.076 13.6 0.1 21 5.7 0.0 2.9 3 0 0 3 3 2 0 AAA domain MnmE_helical PF12631.7 EEA26830.1 - 0.087 13.0 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 MnmE helical domain AAA_27 PF13514.6 EEA26830.1 - 0.1 12.2 0.0 13 5.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain Stork_head PF10264.9 EEA26830.1 - 0.13 12.4 0.2 0.42 10.8 0.2 1.8 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain DUF3584 PF12128.8 EEA26830.1 - 0.16 9.5 1.3 4.3 4.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) QWRF PF04484.12 EEA26830.1 - 7.6 6.2 7.6 0.7 9.6 0.2 2.7 3 0 0 3 3 3 0 QWRF family ICL PF00463.21 EEA26831.1 - 1.3e-192 640.9 0.1 1.6e-192 640.7 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EEA26831.1 - 3.9e-09 36.3 0.1 1.1e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Patatin PF01734.22 EEA26831.1 - 0.11 12.7 1.0 1.1 9.4 0.3 2.3 2 0 0 2 2 2 0 Patatin-like phospholipase Citrate_synt PF00285.21 EEA26832.1 - 1.4e-97 327.0 0.0 1.7e-97 326.7 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain AMP-binding PF00501.28 EEA26833.1 - 1.9e-67 227.7 0.0 2.4e-67 227.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA26833.1 - 2.8e-05 25.0 0.0 6.6e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RPW8 PF05659.11 EEA26834.1 - 0.013 15.2 2.3 0.035 13.8 0.0 2.7 3 1 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 GAS PF13851.6 EEA26834.1 - 0.065 12.6 12.8 0.12 11.7 7.7 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding ABC_tran_CTD PF16326.5 EEA26834.1 - 0.11 12.7 5.7 0.97 9.7 0.1 3.9 2 1 2 4 4 4 0 ABC transporter C-terminal domain XhlA PF10779.9 EEA26834.1 - 0.11 12.7 1.5 1.7 8.9 0.1 3.2 3 0 0 3 3 3 0 Haemolysin XhlA FAM76 PF16046.5 EEA26834.1 - 0.36 10.1 14.4 0.49 9.7 3.0 2.1 1 1 1 2 2 2 0 FAM76 protein MIT_C PF16565.5 EEA26834.1 - 3.2 7.7 6.0 7.3 6.6 0.8 3.0 4 0 0 4 4 4 0 Phospholipase D-like domain at C-terminus of MIT LtrA PF06772.11 EEA26835.1 - 1.5e-32 113.2 20.9 2.1e-32 112.8 20.9 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF3999 PF13163.6 EEA26835.1 - 0.081 12.1 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3999) MmgE_PrpD PF03972.14 EEA26836.1 - 4.4e-145 483.6 0.0 5.3e-145 483.3 0.0 1.1 1 0 0 1 1 1 1 MmgE/PrpD family DUF1266 PF06889.11 EEA26836.1 - 0.0033 17.5 0.0 0.23 11.5 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1266) DNA_methylase PF00145.17 EEA26837.1 - 4.6e-39 134.7 0.0 3.6e-28 98.9 0.0 2.2 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase BAH PF01426.18 EEA26837.1 - 0.047 13.6 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 BAH domain ENOD40 PF08247.11 EEA26837.1 - 3.3 7.9 4.9 7.7 6.7 1.0 2.8 2 0 0 2 2 2 0 ENOD40 protein Metallophos PF00149.28 EEA26838.1 - 1.4e-10 42.0 0.1 2.3e-10 41.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA26838.1 - 2.5e-09 37.5 0.2 2.6e-08 34.2 0.2 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Transp_inhibit PF18791.1 EEA26838.1 - 0.03 13.8 0.1 0.071 12.6 0.1 1.6 1 0 0 1 1 1 0 Transport inhibitor response 1 protein domain Glyco_hydro_62 PF03664.13 EEA26839.1 - 5.1e-137 455.7 9.3 5.9e-137 455.4 9.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 HhH-GPD PF00730.25 EEA26840.1 - 9.7e-08 32.4 0.0 2.4e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EEA26840.1 - 0.029 14.2 0.0 0.085 12.8 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.6 EEA26840.1 - 0.14 12.7 0.0 0.47 11.1 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain CENP-U PF13097.6 EEA26840.1 - 5.7 6.9 10.1 4.7 7.1 3.0 2.4 1 1 1 2 2 2 0 CENP-A nucleosome associated complex (NAC) subunit 2-Hacid_dh_C PF02826.19 EEA26841.1 - 8.9e-54 181.5 0.0 1.3e-53 181.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EEA26841.1 - 2.6e-29 101.6 0.0 3.2e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EEA26841.1 - 0.00047 20.4 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EEA26841.1 - 0.0046 16.3 0.2 0.16 11.3 0.2 2.2 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EEA26841.1 - 0.018 14.7 0.1 0.03 13.9 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AdoHcyase_NAD PF00670.21 EEA26841.1 - 0.03 14.4 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TrkA_N PF02254.18 EEA26841.1 - 0.042 14.1 0.2 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain IlvN PF07991.12 EEA26841.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ThiF PF00899.21 EEA26841.1 - 0.16 11.3 0.1 0.33 10.2 0.1 1.5 1 0 0 1 1 1 0 ThiF family Fungal_trans_2 PF11951.8 EEA26842.1 - 1.3e-06 27.5 0.2 1.8e-06 27.0 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain 3Beta_HSD PF01073.19 EEA26843.1 - 1.4e-18 66.9 0.0 3.4e-18 65.6 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA26843.1 - 6.8e-16 58.5 0.0 1.5e-15 57.3 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA26843.1 - 1.7e-10 41.1 0.0 3e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EEA26843.1 - 3.7e-10 39.4 0.0 6e-09 35.4 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EEA26843.1 - 1.2e-09 38.1 0.2 6.7e-09 35.6 0.2 1.9 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EEA26843.1 - 1.1e-08 34.8 0.0 3.4e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EEA26843.1 - 2.4e-05 23.6 0.0 7.1e-05 22.1 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EEA26843.1 - 0.0007 19.1 0.3 0.14 11.6 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase RmlD_sub_bind PF04321.17 EEA26843.1 - 0.038 13.1 0.1 0.23 10.5 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain KR PF08659.10 EEA26843.1 - 0.041 13.8 0.5 1.5 8.7 0.0 2.6 3 1 0 3 3 3 0 KR domain Zn_clus PF00172.18 EEA26845.1 - 5.5e-08 32.8 12.7 9.7e-08 32.0 12.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA26845.1 - 0.0004 19.3 0.5 0.0007 18.5 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 EEA26846.1 - 8.1e-09 35.2 0.0 1.8e-08 34.1 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EEA26846.1 - 2.6e-05 24.2 0.0 4.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EEA26846.1 - 0.0044 16.6 0.0 0.007 15.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 EEA26846.1 - 0.039 14.2 0.0 0.067 13.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Aldedh PF00171.22 EEA26847.1 - 6.6e-120 400.7 0.0 8.3e-120 400.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Clostridium_P47 PF06597.11 EEA26848.1 - 0.022 13.5 6.2 0.025 13.3 6.2 1.0 1 0 0 1 1 1 0 Clostridium P-47 protein AmpE PF17113.5 EEA26848.1 - 0.11 11.8 1.1 0.12 11.7 1.1 1.0 1 0 0 1 1 1 0 Regulatory signalling modulator protein AmpE GPHR_N PF12537.8 EEA26848.1 - 1.3 9.1 4.6 1.4 9.0 4.6 1.4 1 1 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal KCNQ2_u3 PF16642.5 EEA26850.1 - 0.13 13.2 0.3 0.28 12.2 0.3 1.4 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Mt_ATP-synt_D PF05873.12 EEA26851.1 - 3.3e-23 82.3 1.1 4.1e-23 81.9 1.1 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DUF3251 PF11622.8 EEA26851.1 - 0.065 12.9 0.0 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3251) T2SSM_b PF10741.9 EEA26851.1 - 0.072 12.9 0.2 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M subtype b Helo_like_N PF17111.5 EEA26851.1 - 0.076 12.4 0.3 0.12 11.7 0.3 1.4 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins RasGAP_C PF03836.15 EEA26851.1 - 0.17 12.0 1.1 7.8 6.6 0.1 2.2 2 0 0 2 2 2 0 RasGAP C-terminus ATPase PF06745.13 EEA26851.1 - 0.19 11.1 0.6 0.41 10.0 0.4 1.6 1 1 1 2 2 2 0 KaiC NAC PF01849.18 EEA26852.1 - 1.9e-22 79.0 0.0 7.8e-22 77.0 0.0 2.0 2 0 0 2 2 2 1 NAC domain RNA_pol_Rpo13 PF12136.8 EEA26852.1 - 0.059 13.3 1.7 0.059 13.3 1.7 2.6 3 0 0 3 3 3 0 RNA polymerase Rpo13 subunit HTH domain PGA2 PF07543.12 EEA26852.1 - 0.38 10.7 6.9 0.41 10.6 4.7 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 Pes-10 PF07149.11 EEA26852.1 - 1.4 7.9 5.9 1.2 8.1 5.1 1.4 2 0 0 2 2 2 0 Pes-10 Ribosomal_L14e PF01929.17 EEA26853.1 - 6.2e-32 109.9 0.5 8.8e-32 109.4 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EEA26853.1 - 4.6e-07 29.6 0.4 7.9e-07 28.8 0.4 1.4 1 0 0 1 1 1 1 KOW motif Prot_ATP_ID_OB PF16450.5 EEA26853.1 - 0.028 14.4 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain DUF1778 PF08681.11 EEA26853.1 - 0.045 13.7 0.1 1.1 9.3 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1778) YIF1 PF03878.15 EEA26854.1 - 2.8e-99 331.5 4.8 3.3e-99 331.2 4.8 1.0 1 0 0 1 1 1 1 YIF1 SRP-alpha_N PF04086.13 EEA26855.1 - 4.6e-80 269.7 0.0 5.9e-80 269.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EEA26855.1 - 4.4e-48 163.5 0.0 8e-48 162.7 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EEA26855.1 - 3.8e-11 43.1 0.0 9.2e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EEA26855.1 - 6.8e-07 28.5 0.0 1.2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EEA26855.1 - 0.0016 18.9 0.0 0.0036 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EEA26855.1 - 0.0049 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EEA26855.1 - 0.007 16.4 0.0 0.026 14.6 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 EEA26855.1 - 0.018 14.8 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EEA26855.1 - 0.041 14.4 0.0 0.16 12.5 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_31 PF13614.6 EEA26855.1 - 0.043 13.7 0.1 0.29 11.0 0.0 2.0 1 1 1 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EEA26855.1 - 0.059 13.4 0.1 0.25 11.4 0.1 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Fer4_NifH PF00142.18 EEA26855.1 - 0.06 12.8 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family NTPase_1 PF03266.15 EEA26855.1 - 0.14 12.0 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 NTPase DUF4682 PF15733.5 EEA26855.1 - 0.28 11.8 1.0 0.86 10.2 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4682) NAD_binding_4 PF07993.12 EEA26856.1 - 6.1e-26 91.1 0.0 9e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EEA26856.1 - 1.4e-18 66.7 0.0 2.3e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EEA26856.1 - 1.1e-05 25.1 0.0 1.8e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Prenyltrans PF00432.21 EEA26856.1 - 0.039 13.7 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat DUF4407 PF14362.6 EEA26856.1 - 0.1 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Semialdhyde_dh PF01118.24 EEA26856.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Glyco_hydro_39 PF01229.17 EEA26856.1 - 0.21 10.1 0.6 3.2 6.2 0.0 2.6 3 0 0 3 3 3 0 Glycosyl hydrolases family 39 Catalase PF00199.19 EEA26857.1 - 4e-172 572.6 0.1 5.1e-172 572.3 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EEA26857.1 - 3.8e-16 59.0 0.2 1.3e-15 57.4 0.2 2.0 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EEA26857.1 - 1.2e-06 28.3 0.1 2.1e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 EEA26857.1 - 2.3e-06 27.5 0.0 1.8e-05 24.6 0.0 2.0 1 1 1 2 2 2 1 DJ-1/PfpI family CutC PF03932.14 EEA26858.1 - 6.9e-44 149.8 0.8 1e-25 90.4 0.1 3.8 2 1 0 2 2 2 2 CutC family QRPTase_C PF01729.19 EEA26858.1 - 0.13 12.0 0.0 0.39 10.5 0.0 1.7 1 1 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain DHDPS PF00701.22 EEA26858.1 - 0.13 10.9 0.2 0.24 10.1 0.2 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family SHOCT PF09851.9 EEA26858.1 - 0.21 11.4 0.9 0.66 9.8 0.9 1.9 1 0 0 1 1 1 0 Short C-terminal domain MFS_1 PF07690.16 EEA26862.1 - 3.2e-44 151.3 39.0 1.5e-36 126.1 14.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA26862.1 - 4.9e-14 52.0 11.3 2.1e-13 50.0 0.8 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 EEA26862.1 - 3e-05 23.1 4.5 3e-05 23.1 4.5 2.7 1 1 1 2 2 2 1 MFS_1 like family MFS_4 PF06779.14 EEA26862.1 - 5e-05 22.8 2.5 5e-05 22.8 2.5 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EEA26862.1 - 0.0045 15.5 0.7 0.0073 14.8 0.7 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.18 EEA26862.1 - 0.05 12.3 0.1 0.097 11.4 0.1 1.4 1 0 0 1 1 1 0 Reduced folate carrier MFS_2 PF13347.6 EEA26862.1 - 0.2 10.1 16.4 0.4 9.2 3.9 3.4 2 2 2 4 4 3 0 MFS/sugar transport protein BT1 PF03092.16 EEA26862.1 - 0.35 9.1 4.8 0.24 9.6 1.2 2.2 2 0 0 2 2 2 0 BT1 family DUF2530 PF10745.9 EEA26862.1 - 8.4 6.7 7.5 2.4 8.5 2.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) ABC_tran PF00005.27 EEA26863.1 - 5.7e-27 94.9 0.3 9.7e-27 94.2 0.3 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EEA26863.1 - 2.2e-25 89.4 30.6 3e-25 88.9 30.6 1.2 1 0 0 1 1 1 1 ABC-2 type transporter AAA_16 PF13191.6 EEA26863.1 - 7.9e-06 26.4 0.0 1.3e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA26863.1 - 1.4e-05 25.1 0.2 0.00011 22.1 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EEA26863.1 - 2.7e-05 24.1 0.3 0.033 14.0 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA26863.1 - 0.00017 21.1 0.2 0.00048 19.6 0.2 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA26863.1 - 0.00041 20.6 0.1 0.00093 19.5 0.1 1.7 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EEA26863.1 - 0.0016 18.4 0.0 0.0037 17.2 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_28 PF13521.6 EEA26863.1 - 0.0017 18.6 0.0 0.0037 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_13 PF13166.6 EEA26863.1 - 0.0032 16.2 0.1 0.027 13.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA26863.1 - 0.0039 17.7 0.1 0.012 16.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EEA26863.1 - 0.0052 17.2 0.2 0.046 14.1 0.2 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EEA26863.1 - 0.011 15.4 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EEA26863.1 - 0.02 14.1 0.1 0.075 12.2 0.0 1.8 1 1 1 2 2 2 0 NB-ARC domain AAA_14 PF13173.6 EEA26863.1 - 0.036 14.1 0.0 0.095 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EEA26863.1 - 0.044 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EEA26863.1 - 0.046 14.2 0.4 0.11 13.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 EEA26863.1 - 0.055 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 EEA26863.1 - 0.056 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA26863.1 - 0.085 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EEA26863.1 - 0.094 12.5 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 EEA26863.1 - 0.11 12.9 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.25 EEA26863.1 - 0.11 12.1 0.0 0.25 10.9 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain RuvB_N PF05496.12 EEA26863.1 - 0.15 11.8 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain cobW PF02492.19 EEA26863.1 - 0.18 11.3 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF423 PF04241.15 EEA26863.1 - 1.6 8.9 4.7 5.1 7.4 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF423) Bac_luciferase PF00296.20 EEA26864.1 - 1.6e-69 234.8 0.1 1.9e-69 234.5 0.1 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Abhydrolase_6 PF12697.7 EEA26865.1 - 3.7e-14 53.9 0.0 4.8e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA26865.1 - 1.4e-11 44.5 0.0 1.9e-10 40.8 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA26865.1 - 1.1e-06 28.2 0.0 2.1e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EEA26865.1 - 0.0013 18.9 0.1 0.0024 18.0 0.1 1.5 1 1 0 1 1 1 1 Thioesterase domain Ser_hydrolase PF06821.13 EEA26865.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_5 PF12695.7 EEA26865.1 - 0.059 13.1 0.0 0.24 11.2 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EEA26865.1 - 0.15 11.7 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase TPR_12 PF13424.6 EEA26866.1 - 2e-22 79.3 13.7 7e-09 35.9 0.2 5.1 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 EEA26866.1 - 4.1e-18 64.6 4.4 2.5e-05 24.0 0.1 6.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 EEA26866.1 - 8.2e-10 38.0 8.0 0.35 11.0 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA26866.1 - 1.6e-08 34.0 7.5 0.014 15.5 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA26866.1 - 2e-07 31.2 4.4 0.51 11.3 0.0 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA26866.1 - 2.2e-07 30.5 8.5 0.32 11.3 0.3 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA26866.1 - 1.9e-05 24.2 2.6 0.38 10.6 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA26866.1 - 0.0044 17.6 2.6 4.9 7.9 0.0 4.1 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA26866.1 - 0.0047 17.4 4.9 0.7 10.4 0.2 4.1 3 2 2 5 5 5 1 Tetratricopeptide repeat DCAF15_WD40 PF14939.6 EEA26866.1 - 0.0063 16.2 0.4 0.015 15.0 0.4 1.5 1 0 0 1 1 1 1 DDB1-and CUL4-substrate receptor 15, WD repeat TPR_5 PF12688.7 EEA26866.1 - 0.073 13.3 0.2 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Tetratrico peptide repeat Birna_VP2 PF01766.17 EEA26866.1 - 0.16 10.9 0.2 0.26 10.2 0.2 1.2 1 0 0 1 1 1 0 Birnavirus VP2 protein TPR_4 PF07721.14 EEA26866.1 - 0.17 12.6 0.2 13 6.7 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat zf_UBZ PF18439.1 EEA26866.1 - 1.1 8.9 6.4 11 5.7 0.3 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-MYND PF01753.18 EEA26866.1 - 2.9 8.1 23.2 0.038 14.1 12.8 2.6 2 1 0 2 2 2 0 MYND finger Hus1 PF04005.12 EEA26867.1 - 2.4e-100 335.4 0.0 3e-100 335.1 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein Hexokinase_2 PF03727.16 EEA26868.1 - 1.1e-72 244.4 0.0 1.5e-72 243.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EEA26868.1 - 2.7e-64 216.7 0.0 4e-64 216.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase FAD_binding_3 PF01494.19 EEA26869.1 - 6.7e-08 32.2 0.0 1.2e-07 31.3 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EEA26869.1 - 4.8e-06 25.9 0.0 3.4e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EEA26869.1 - 0.0048 16.2 0.1 0.017 14.4 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA26869.1 - 0.0064 16.7 0.1 0.016 15.5 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA26869.1 - 0.0091 15.6 0.1 1.7 8.1 0.2 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA26869.1 - 0.025 13.8 0.0 0.087 12.0 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA26869.1 - 0.16 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Thi4 family GAS2 PF02187.17 EEA26870.1 - 2.3e-06 27.6 0.3 5.6e-06 26.4 0.3 1.6 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain IBR PF01485.21 EEA26871.1 - 4.5e-19 68.4 40.9 7.6e-15 54.9 3.8 4.1 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 EEA26871.1 - 3.4e-17 62.8 0.0 6.9e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_11 PF17123.5 EEA26871.1 - 0.0097 15.6 7.0 0.0097 15.6 7.0 2.4 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_2 PF13639.6 EEA26871.1 - 0.025 14.9 10.8 0.025 14.9 10.8 4.2 3 1 1 4 4 4 0 Ring finger domain PAP2 PF01569.21 EEA26872.1 - 2.4e-12 46.8 3.9 2.4e-12 46.8 3.9 2.2 1 1 1 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 EEA26872.1 - 0.02 15.0 0.3 0.56 10.3 0.3 2.4 1 1 0 1 1 1 0 Divergent PAP2 family DELLA PF12041.8 EEA26872.1 - 0.17 11.8 0.1 0.34 10.8 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal PAP2 PF01569.21 EEA26873.1 - 1.7e-12 47.2 3.9 1.7e-12 47.2 3.9 2.2 1 1 1 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 EEA26873.1 - 0.014 15.5 0.4 0.42 10.8 0.2 2.4 1 1 0 1 1 1 0 Divergent PAP2 family DELLA PF12041.8 EEA26873.1 - 0.15 12.0 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal DUF3402 PF11882.8 EEA26874.1 - 7.6e-189 628.6 0.0 1e-188 628.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EEA26874.1 - 1e-88 297.3 0.0 1.5e-88 296.8 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein DUF3720 PF12517.8 EEA26874.1 - 0.017 16.1 1.3 0.017 16.1 1.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3720) ODV-E18 PF10717.9 EEA26874.1 - 0.17 11.8 0.1 6 6.8 0.0 2.8 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 zf-C2H2_4 PF13894.6 EEA26875.1 - 7.3e-07 29.5 29.8 0.028 15.2 0.1 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EEA26875.1 - 0.015 15.3 14.0 0.017 15.1 0.1 3.7 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EEA26875.1 - 0.021 15.2 15.0 0.13 12.6 3.8 3.5 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EEA26875.1 - 0.12 12.9 0.1 0.12 12.9 0.1 6.5 6 0 0 6 6 6 0 Zinc finger, C2H2 type Ribosomal_L28e PF01778.17 EEA26876.1 - 2.9e-40 137.6 1.1 4.7e-40 136.9 1.1 1.3 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 EEA26876.1 - 8.9e-30 103.2 14.2 8.9e-30 103.2 14.2 2.3 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 EEA26876.1 - 1.1e-07 31.6 13.7 1.4e-07 31.3 13.7 1.1 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.12 EEA26876.1 - 0.8 7.8 26.8 1 7.5 26.8 1.2 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 EEA26876.1 - 0.86 8.1 27.5 1.1 7.7 27.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mso1_Sec1_bdg PF14475.6 EEA26877.1 - 2e-15 56.1 0.1 5.1e-15 54.8 0.1 1.7 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Sugar_tr PF00083.24 EEA26878.1 - 2.3e-84 283.9 19.0 2.7e-84 283.6 19.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA26878.1 - 9e-29 100.5 22.6 9e-29 100.5 22.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA26878.1 - 4.7e-07 28.6 1.9 9.1e-07 27.7 1.9 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sec16_C PF12931.7 EEA26879.1 - 1.1e-112 376.6 0.0 1.5e-112 376.2 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16_N PF12935.7 EEA26879.1 - 9.3e-54 183.1 22.5 9.3e-54 183.1 22.5 4.8 2 1 2 4 4 4 1 Vesicle coat trafficking protein Sec16 N-terminus Sec16 PF12932.7 EEA26879.1 - 1.1e-32 113.1 0.0 2.4e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region UPF0449 PF15136.6 EEA26879.1 - 0.16 12.4 1.8 0.72 10.4 1.8 2.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF3499 PF12005.8 EEA26879.1 - 0.22 12.1 0.9 0.74 10.4 0.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) PhoLip_ATPase_C PF16212.5 EEA26880.1 - 6.5e-49 166.9 8.6 6.5e-49 166.9 8.6 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA26880.1 - 4.7e-16 58.2 0.8 1.2e-15 57.0 0.8 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EEA26880.1 - 6.4e-14 52.7 3.3 2.1e-08 34.7 0.6 3.4 2 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA26880.1 - 4.5e-08 33.1 0.0 2.8e-06 27.3 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA26880.1 - 0.0037 17.0 0.0 0.0086 15.8 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EEA26880.1 - 0.044 13.3 0.0 0.044 13.3 0.0 2.8 3 0 0 3 3 3 0 E1-E2 ATPase CCB2_CCB4 PF11152.8 EEA26880.1 - 0.079 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 RabGAP-TBC PF00566.18 EEA26881.1 - 1.9e-40 138.8 0.2 3.8e-40 137.8 0.2 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EEA26881.1 - 1.1e-06 28.2 0.0 2.2e-05 24.0 0.0 2.3 1 1 0 1 1 1 1 Rab-binding domain (RBD) Peptidase_M50B PF13398.6 EEA26882.1 - 9.5e-59 198.4 22.2 1.2e-58 198.0 22.2 1.1 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.22 EEA26882.1 - 0.01 15.1 0.3 0.021 14.1 0.3 1.4 1 0 0 1 1 1 0 Peptidase family M50 Peptidase_M41 PF01434.18 EEA26882.1 - 0.24 11.2 0.2 0.36 10.6 0.2 1.2 1 0 0 1 1 1 0 Peptidase family M41 CRT10 PF08728.10 EEA26883.1 - 1.6e-17 63.0 0.0 1.6e-12 46.5 0.0 2.8 2 1 0 2 2 2 2 CRT10 GET2 PF08690.10 EEA26883.1 - 2.7 7.6 6.7 5.2 6.6 6.7 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 MMtag PF10159.9 EEA26884.1 - 1.8e-34 117.9 3.1 1.8e-34 117.9 3.1 2.5 2 1 0 2 2 2 1 Multiple myeloma tumor-associated AadA_C PF18280.1 EEA26884.1 - 0.063 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Aminoglycoside adenyltransferase C-terminal domain Glyco_hydro_63 PF03200.16 EEA26885.1 - 4e-172 573.4 7.9 5.3e-171 569.7 7.9 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EEA26885.1 - 6.6e-87 291.4 0.0 1.8e-86 289.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EEA26885.1 - 0.0018 17.2 4.1 0.0044 15.9 3.5 1.7 1 1 0 1 1 1 1 Trehalase DAO PF01266.24 EEA26886.1 - 7e-69 233.1 0.5 8e-69 232.9 0.5 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EEA26886.1 - 1.3e-05 24.3 0.6 0.011 14.6 0.1 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 EEA26886.1 - 3.5e-05 23.9 0.3 8.8e-05 22.7 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA26886.1 - 4.2e-05 22.9 0.1 0.22 10.7 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA26886.1 - 0.00036 21.0 0.3 1.1 9.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA26886.1 - 0.002 18.2 0.1 1.8 8.5 0.1 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding MCRA PF06100.11 EEA26886.1 - 0.013 14.3 0.1 0.019 13.8 0.1 1.2 1 0 0 1 1 1 0 MCRA family Thi4 PF01946.17 EEA26886.1 - 0.015 14.6 0.2 0.025 13.8 0.2 1.4 1 0 0 1 1 1 0 Thi4 family Sacchrp_dh_NADP PF03435.18 EEA26886.1 - 0.032 14.5 0.1 0.1 12.9 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_2 PF00890.24 EEA26886.1 - 0.059 12.4 0.1 3 6.8 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 EEA26886.1 - 0.082 12.0 0.1 1.1 8.2 0.0 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A SNRNP27 PF08648.12 EEA26887.1 - 7.9e-25 86.7 1.1 7.9e-25 86.7 1.1 2.0 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins Gly_transf_sug PF04488.15 EEA26888.1 - 1.4e-09 38.5 0.0 2.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EEA26888.1 - 0.25 10.6 0.0 0.42 9.9 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain PIG-L PF02585.17 EEA26889.1 - 2.6e-13 50.7 0.0 5.2e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Elong_Iki1 PF10483.9 EEA26890.1 - 6.4e-104 347.6 0.0 7.4e-104 347.4 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Longin PF13774.6 EEA26891.1 - 7.6e-27 93.2 0.6 1.3e-26 92.5 0.6 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EEA26891.1 - 1.3e-13 50.5 0.0 2.3e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin SLM4 PF16818.5 EEA26891.1 - 0.00072 19.6 0.5 0.048 13.6 0.1 2.2 1 1 1 2 2 2 2 Protein SLM4 DUF3958 PF13125.6 EEA26891.1 - 0.085 13.1 0.5 1.9 8.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) Longin PF13774.6 EEA26892.1 - 7.2e-27 93.3 0.6 1.2e-26 92.5 0.6 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EEA26892.1 - 4.7e-11 42.3 0.1 8.9e-11 41.4 0.1 1.4 1 0 0 1 1 1 1 Synaptobrevin SLM4 PF16818.5 EEA26892.1 - 0.00062 19.8 0.4 0.04 13.9 0.1 2.2 1 1 1 2 2 2 2 Protein SLM4 DUF3958 PF13125.6 EEA26892.1 - 0.078 13.2 0.5 1.9 8.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) ASXH PF13919.6 EEA26893.1 - 7.4e-39 132.9 2.1 7.4e-39 132.9 2.1 1.7 2 0 0 2 2 2 1 Asx homology domain adh_short PF00106.25 EEA26894.1 - 2e-22 79.6 0.0 4.9e-22 78.3 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA26894.1 - 6.4e-16 58.6 0.0 1.1e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Rap1-DNA-bind PF09197.10 EEA26894.1 - 0.043 14.4 0.4 0.1 13.2 0.0 1.7 2 0 0 2 2 2 0 Rap1, DNA-binding Menin PF05053.13 EEA26894.1 - 0.044 12.2 2.1 0.057 11.8 2.1 1.1 1 0 0 1 1 1 0 Menin Asparaginase_C PF17763.1 EEA26894.1 - 0.084 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain CLPTM1 PF05602.12 EEA26895.1 - 1.1e-164 548.5 0.4 1.4e-164 548.2 0.4 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) CENP-I PF07778.11 EEA26896.1 - 2.8e-39 135.2 0.0 1.6e-38 132.7 0.0 1.9 1 1 0 1 1 1 1 Mis6 Transcrip_reg PF01709.20 EEA26897.1 - 1.7e-69 233.9 0.7 2e-69 233.7 0.7 1.0 1 0 0 1 1 1 1 Transcriptional regulator HEAT_2 PF13646.6 EEA26898.1 - 2e-10 40.9 2.2 0.13 12.7 0.1 7.4 7 1 1 8 8 8 3 HEAT repeats HEAT PF02985.22 EEA26898.1 - 2.5e-05 24.2 15.6 3.4 8.2 0.2 9.2 10 0 0 10 10 10 3 HEAT repeat Abhydrolase_1 PF00561.20 EEA26900.1 - 1.1e-13 51.5 0.0 2.8e-13 50.1 0.0 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA26900.1 - 2.2e-09 38.2 0.0 3.5e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA26900.1 - 1e-05 24.9 0.0 1.4e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EEA26900.1 - 0.0032 17.2 0.0 0.14 11.9 0.0 2.7 2 1 1 3 3 3 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EEA26900.1 - 0.029 14.1 0.1 0.14 11.8 0.0 2.0 1 1 1 2 2 2 0 PGAP1-like protein Ser_hydrolase PF06821.13 EEA26900.1 - 0.08 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase Jnk-SapK_ap_N PF09744.9 EEA26900.1 - 0.18 12.0 0.1 0.18 12.0 0.1 1.7 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 TPR_12 PF13424.6 EEA26901.1 - 2.7e-43 146.1 12.3 5.3e-14 52.3 0.2 5.0 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 EEA26901.1 - 4.1e-43 144.1 18.0 4.7e-09 35.8 0.0 8.6 10 0 0 10 10 10 7 Tetratricopeptide repeat NB-ARC PF00931.22 EEA26901.1 - 8.3e-09 35.0 0.0 2.3e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain TPR_7 PF13176.6 EEA26901.1 - 1.3e-07 31.1 4.9 0.55 10.4 0.1 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA26901.1 - 2.6e-07 30.3 11.0 0.00025 20.6 0.6 3.8 1 1 2 4 4 4 3 MalT-like TPR region TPR_2 PF07719.17 EEA26901.1 - 6.1e-07 29.1 6.2 0.63 10.3 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat NACHT PF05729.12 EEA26901.1 - 1.4e-06 28.4 0.0 4.6e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 NACHT domain TPR_16 PF13432.6 EEA26901.1 - 7.3e-06 26.5 1.0 0.28 11.8 0.0 4.4 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA26901.1 - 2.2e-05 24.9 2.0 3.4 8.7 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA26901.1 - 6.3e-05 22.9 3.7 8.9 6.8 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat Helo_like_N PF17111.5 EEA26901.1 - 9.3e-05 21.9 1.6 0.00019 20.8 1.6 1.5 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EEA26901.1 - 0.00018 21.7 7.0 0.0028 17.8 1.6 3.1 2 1 1 3 3 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_19 PF14559.6 EEA26901.1 - 0.0097 16.4 0.5 10 6.7 0.0 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.14 EEA26901.1 - 0.022 15.4 1.7 3.7 8.4 0.4 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EEA26901.1 - 0.038 14.4 0.0 14 6.3 0.0 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA26901.1 - 0.76 9.7 4.8 1.2 9.0 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1640 PF07798.11 EEA26902.1 - 1e-39 136.4 5.2 1.6e-39 135.7 5.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) GAIN_A PF18619.1 EEA26902.1 - 8.9 6.6 7.8 0.49 10.6 1.2 2.3 2 0 0 2 2 2 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A EptA_B_N PF08019.12 EEA26903.1 - 6.3 6.7 13.3 0.11 12.4 2.5 2.6 3 0 0 3 3 3 0 Phosphoethanolamine transferase EptA/EptB DUF5527 PF17665.1 EEA26903.1 - 8.1 6.0 6.3 0.73 9.4 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5527) Methyltransf_2 PF00891.18 EEA26904.1 - 1.6e-19 70.1 0.0 2.3e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EEA26904.1 - 9.1e-05 22.4 0.3 0.00021 21.2 0.3 1.5 1 0 0 1 1 1 1 Dimerisation domain Vps51 PF08700.11 EEA26905.1 - 2.3e-14 53.2 0.3 1.8e-13 50.4 0.0 2.6 2 0 0 2 2 2 1 Vps51/Vps67 Rep_1 PF01446.17 EEA26905.1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Replication protein D123 PF07065.14 EEA26906.1 - 2.7e-116 388.0 0.4 3.7e-116 387.6 0.4 1.2 1 0 0 1 1 1 1 D123 ECH_1 PF00378.20 EEA26907.1 - 1.2e-27 96.8 0.0 2.8e-27 95.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA26907.1 - 8.2e-16 58.4 0.0 1e-15 58.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAC PF01849.18 EEA26907.1 - 0.028 14.4 0.0 0.084 12.9 0.0 1.7 2 0 0 2 2 2 0 NAC domain CENP-B_N PF04218.13 EEA26907.1 - 0.053 13.2 0.1 4.2 7.1 0.0 2.4 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain ECH_1 PF00378.20 EEA26908.1 - 1.2e-27 96.8 0.0 2.8e-27 95.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA26908.1 - 8.2e-16 58.4 0.0 1e-15 58.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAC PF01849.18 EEA26908.1 - 0.028 14.4 0.0 0.084 12.9 0.0 1.7 2 0 0 2 2 2 0 NAC domain CENP-B_N PF04218.13 EEA26908.1 - 0.053 13.2 0.1 4.2 7.1 0.0 2.4 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain ECH_1 PF00378.20 EEA26909.1 - 1.2e-27 96.8 0.0 2.8e-27 95.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA26909.1 - 8.2e-16 58.4 0.0 1e-15 58.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAC PF01849.18 EEA26909.1 - 0.028 14.4 0.0 0.084 12.9 0.0 1.7 2 0 0 2 2 2 0 NAC domain CENP-B_N PF04218.13 EEA26909.1 - 0.053 13.2 0.1 4.2 7.1 0.0 2.4 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain Pet100 PF09803.9 EEA26910.1 - 3.4e-18 65.9 0.3 5.1e-18 65.4 0.3 1.3 1 1 0 1 1 1 1 Pet100 M_domain PF12938.7 EEA26910.1 - 0.017 15.0 0.0 0.018 14.8 0.0 1.1 1 0 0 1 1 1 0 M domain of GW182 SPT_ssu-like PF11779.8 EEA26911.1 - 8e-26 89.4 2.7 1.1e-25 88.9 2.7 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like SPT_ssu-like PF11779.8 EEA26912.1 - 8e-26 89.4 2.7 1.1e-25 88.9 2.7 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like RF-1 PF00472.20 EEA26913.1 - 2.5e-23 82.2 6.8 2.5e-23 82.2 6.8 1.3 1 1 0 1 1 1 1 RF-1 domain DUF4746 PF15928.5 EEA26913.1 - 1.3 8.4 9.0 1.5 8.2 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CAS_CSE1 PF03378.15 EEA26914.1 - 1.5e-199 663.0 0.9 3.3e-199 661.9 0.6 1.8 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EEA26914.1 - 7.3e-156 518.6 2.9 1.1e-155 518.1 2.9 1.3 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 EEA26914.1 - 7.3e-17 61.1 0.1 3.3e-16 58.9 0.0 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF1529 PF07485.11 EEA26914.1 - 0.055 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1259) DUF3384 PF11864.8 EEA26915.1 - 6.4e-94 315.5 6.3 6.4e-94 315.5 6.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EEA26915.1 - 2.9e-50 170.4 0.0 5e-50 169.6 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EEA26915.1 - 1e-32 113.7 0.4 9.4e-29 100.6 0.0 3.6 4 0 0 4 4 4 3 Tuberin RTP1_C1 PF10363.9 EEA26915.1 - 0.0025 18.0 0.3 0.027 14.6 0.1 2.7 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Bystin PF05291.11 EEA26915.1 - 0.021 14.2 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Bystin Phosphodiest PF01663.22 EEA26916.1 - 3.3e-12 46.7 0.5 6.1e-12 45.8 0.5 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EEA26916.1 - 2.8e-05 23.6 0.3 5.8e-05 22.6 0.3 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EEA26916.1 - 6.9e-05 22.4 0.0 0.00016 21.2 0.0 1.6 1 1 1 2 2 2 1 Sulfatase HupE_UreJ_2 PF13795.6 EEA26916.1 - 0.041 13.5 1.0 0.12 12.0 1.0 1.8 1 0 0 1 1 1 0 HupE / UreJ protein Man-6-P_recep PF02157.15 EEA26916.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Mannose-6-phosphate receptor MAP65_ASE1 PF03999.12 EEA26916.1 - 0.81 8.3 0.0 0.81 8.3 0.0 1.8 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) Peptidase_U4 PF03419.13 EEA26916.1 - 2.7 7.2 8.0 0.54 9.5 3.6 2.2 1 1 0 1 1 1 0 Sporulation factor SpoIIGA EphA2_TM PF14575.6 EEA26917.1 - 0.1 13.5 0.2 0.14 13.0 0.2 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PUF PF00806.19 EEA26918.1 - 2.6e-62 203.2 13.3 1.6e-09 36.9 0.0 8.9 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat CPL PF08144.11 EEA26918.1 - 0.00054 20.3 3.8 2.6 8.4 0.6 4.5 2 2 4 6 6 6 3 CPL (NUC119) domain LOB PF03195.14 EEA26918.1 - 0.064 13.8 0.6 4.7 7.8 0.2 3.7 2 1 1 4 4 4 0 Lateral organ boundaries (LOB) domain sCache_2 PF17200.4 EEA26918.1 - 0.093 12.6 0.8 1.2e+02 2.5 0.0 4.3 5 0 0 5 5 5 0 Single Cache domain 2 DUF234 PF03008.14 EEA26918.1 - 0.21 12.1 3.1 0.83 10.1 0.1 2.9 3 0 0 3 3 3 0 Archaea bacterial proteins of unknown function cwf21 PF08312.12 EEA26919.1 - 1.8e-16 60.0 15.2 1.8e-16 60.0 15.2 2.0 2 0 0 2 2 2 1 cwf21 domain Asp-B-Hydro_N PF05279.11 EEA26919.1 - 2.7 8.0 18.9 3.6 7.6 18.9 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region HA2 PF04408.23 EEA26920.1 - 1e-27 96.6 0.0 1e-27 96.6 0.0 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EEA26920.1 - 7.8e-13 48.7 0.0 6.6e-12 45.8 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EEA26920.1 - 8e-10 39.0 0.0 1.8e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EEA26920.1 - 1.2e-09 38.2 0.1 3.3e-08 33.5 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA26920.1 - 2e-05 24.7 1.9 1.3 9.0 0.0 3.6 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EEA26920.1 - 0.0042 17.4 0.1 0.028 14.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EEA26920.1 - 0.0061 17.1 0.0 0.0061 17.1 0.0 3.7 4 0 0 4 4 4 1 AAA domain T2SSE PF00437.20 EEA26920.1 - 0.0084 15.2 0.2 0.08 12.0 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EEA26920.1 - 0.018 14.7 0.0 0.053 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA26920.1 - 0.03 14.6 0.0 0.062 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EEA26920.1 - 0.039 13.3 0.0 0.082 12.2 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family TFIIA PF03153.13 EEA26920.1 - 7.1 6.5 30.7 2.8 7.8 24.3 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DDE_1 PF03184.19 EEA26921.1 - 3.4e-23 82.2 0.0 5.9e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA26921.1 - 6e-09 35.8 0.3 2.5e-08 33.8 0.3 2.2 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Pcc1 PF09341.10 EEA26921.1 - 0.078 13.1 0.0 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 Transcription factor Pcc1 PAC3 PF10178.9 EEA26922.1 - 1.4e-05 25.1 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 TRAPPC9-Trs120 PF08626.11 EEA26923.1 - 0 1441.7 0.0 0 1441.3 0.0 1.1 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TPR_12 PF13424.6 EEA26923.1 - 0.016 15.5 0.1 0.042 14.1 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3684 PF12449.8 EEA26924.1 - 0 1417.7 0.5 0 1417.4 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EEA26924.1 - 0.00015 21.6 0.0 0.00042 20.1 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pep1_7 PF17232.2 EEA26924.1 - 0.087 13.3 0.9 6.7 7.2 0.3 2.9 2 0 0 2 2 2 0 Elicitor peptide 1-7 WLM PF08325.10 EEA26924.1 - 1.1 9.3 4.6 1.3 9.1 0.8 2.3 2 0 0 2 2 2 0 WLM domain Chorismate_bind PF00425.18 EEA26925.1 - 5.6e-63 212.9 0.0 8.7e-63 212.3 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EEA26925.1 - 7.8e-24 84.5 0.0 5.2e-23 81.8 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EEA26925.1 - 1.3e-13 51.4 0.0 3.5e-13 50.0 0.0 1.8 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EEA26925.1 - 0.06 13.1 0.9 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Peptidase C26 Aminotran_1_2 PF00155.21 EEA26926.1 - 2.7e-71 240.7 0.0 3.1e-71 240.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II MFS_1 PF07690.16 EEA26927.1 - 1.1e-15 57.4 26.5 2.7e-15 56.1 20.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA26927.1 - 6.2e-13 48.4 10.1 9.5e-13 47.8 10.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter SUIM_assoc PF16619.5 EEA26928.1 - 0.034 14.2 3.9 0.083 13.0 3.9 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 FAD-SLDH PF12318.8 EEA26928.1 - 0.27 11.3 1.1 1.4 9.0 0.6 2.1 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase MFS_1 PF07690.16 EEA26929.1 - 6.3e-20 71.4 13.4 9.2e-17 61.0 3.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Isochorismatase PF00857.20 EEA26930.1 - 2.6e-09 37.5 0.0 0.00013 22.2 0.0 2.1 1 1 1 2 2 2 2 Isochorismatase family Lyase_1 PF00206.20 EEA26931.1 - 1.9e-111 372.4 0.0 3.1e-111 371.7 0.0 1.3 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EEA26931.1 - 3.9e-20 72.0 0.1 1.2e-19 70.5 0.0 1.9 2 0 0 2 2 2 1 Fumarase C C-terminus Acetyltransf_1 PF00583.25 EEA26932.1 - 5.5e-10 39.5 0.1 7.9e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA26932.1 - 3e-08 33.7 0.0 4.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA26932.1 - 2.2e-07 31.2 0.6 3.5e-07 30.5 0.6 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Ribosomal_L24e PF01246.20 EEA26933.1 - 6.7e-28 96.7 0.1 6.7e-28 96.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e GramPos_pilinD1 PF16555.5 EEA26933.1 - 0.059 13.5 2.0 0.084 13.0 2.0 1.2 1 0 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain UQ_con PF00179.26 EEA26934.1 - 1.5e-47 160.8 0.0 1.7e-47 160.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA26934.1 - 0.00024 20.8 0.0 0.00031 20.4 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EEA26934.1 - 0.015 15.2 0.0 0.028 14.3 0.0 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 EEA26934.1 - 0.14 12.5 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain UQ_con PF00179.26 EEA26935.1 - 5.9e-36 123.2 0.0 6.9e-36 123.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA26935.1 - 0.00024 20.8 0.0 0.00034 20.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EEA26935.1 - 0.023 14.6 0.1 0.047 13.6 0.1 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 EEA26935.1 - 0.11 12.7 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain WD40 PF00400.32 EEA26936.1 - 5.4e-07 30.2 24.6 0.0039 18.0 0.1 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EEA26936.1 - 5.5e-06 25.9 18.8 5.5e-06 25.9 18.8 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type RWD PF05773.22 EEA26936.1 - 0.00027 21.2 0.0 0.0006 20.1 0.0 1.5 1 0 0 1 1 1 1 RWD domain Stc1 PF12898.7 EEA26936.1 - 0.29 11.7 3.4 0.3 11.6 1.6 2.0 1 1 0 1 1 1 0 Stc1 domain IBR PF01485.21 EEA26936.1 - 0.32 11.3 11.4 0.11 12.7 6.8 2.5 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EEA26936.1 - 1 9.8 17.5 0.13 12.6 11.3 2.4 2 0 0 2 2 2 0 Ring finger domain zf-RING_14 PF17978.1 EEA26936.1 - 3.1 8.3 7.6 6.7 7.2 7.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TRI12 PF06609.13 EEA26937.1 - 2.6e-36 125.3 31.6 2.6e-36 125.3 31.6 1.6 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EEA26937.1 - 7.3e-15 54.7 51.2 7.3e-15 54.7 51.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA26937.1 - 1.6e-06 27.3 14.0 1.6e-06 27.3 14.0 2.8 3 1 0 3 3 3 2 Sugar (and other) transporter 4HBT PF03061.22 EEA26938.1 - 3.7e-06 27.2 0.1 6.9e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily UCH PF00443.29 EEA26939.1 - 4.6e-51 173.8 0.0 5.8e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EEA26939.1 - 7.6e-11 41.6 0.0 2.1e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family UCH_1 PF13423.6 EEA26939.1 - 2.9e-10 40.2 7.8 4.3e-09 36.4 7.8 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_2 PF14560.6 EEA26939.1 - 0.018 15.5 0.1 1.9 9.0 0.0 2.8 2 0 0 2 2 2 0 Ubiquitin-like domain Peptidase_C98 PF15499.6 EEA26939.1 - 0.021 14.3 0.1 13 5.2 0.0 3.3 3 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase CSRNP_N PF16019.5 EEA26939.1 - 2.2 8.1 5.1 4.6 7.1 5.1 1.4 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF4554 PF15091.6 EEA26939.1 - 4.7 6.0 4.9 6.8 5.5 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) ARPC4 PF05856.12 EEA26940.1 - 4.4e-78 260.6 3.9 4.9e-78 260.5 3.9 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) ARPC4 PF05856.12 EEA26941.1 - 4.9e-71 237.7 4.7 3.1e-63 212.3 2.4 2.0 2 0 0 2 2 2 2 ARP2/3 complex 20 kDa subunit (ARPC4) RRM_1 PF00076.22 EEA26942.1 - 3.2e-05 23.6 0.0 0.00016 21.4 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CREPT PF16566.5 EEA26942.1 - 0.52 10.5 5.7 1.2 9.4 5.7 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour TYW3 PF02676.14 EEA26943.1 - 8.4e-78 260.6 0.7 6.3e-77 257.7 0.7 2.0 1 1 0 1 1 1 1 Methyltransferase TYW3 CENP-B_dimeris PF09026.10 EEA26943.1 - 0.23 11.9 7.6 0.62 10.5 7.6 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TFIIA PF03153.13 EEA26943.1 - 1.4 8.8 13.3 0.25 11.3 8.9 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pro-NT_NN PF07421.11 EEA26943.1 - 4.2 7.6 6.1 0.6 10.3 0.2 2.1 2 0 0 2 2 2 0 Neurotensin/neuromedin N precursor Myc_N PF01056.18 EEA26943.1 - 4.2 7.2 8.9 0.24 11.2 2.7 1.8 2 0 0 2 2 2 0 Myc amino-terminal region DUF2461 PF09365.10 EEA26944.1 - 9e-43 146.7 1.2 2.3e-22 80.0 0.0 2.2 1 1 1 2 2 2 2 Conserved hypothetical protein (DUF2461) Merozoite_SPAM PF07133.11 EEA26944.1 - 3.1 7.8 14.5 1.6 8.7 8.7 2.1 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) Presenilin PF01080.17 EEA26944.1 - 7.9 5.1 8.3 12 4.6 8.3 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EEA26944.1 - 8 4.6 8.1 8.8 4.5 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Zn_clus PF00172.18 EEA26945.1 - 1.5e-08 34.6 6.8 2.1e-08 34.1 6.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Flavoprotein PF02441.19 EEA26947.1 - 1.7e-43 148.1 1.6 5.6e-43 146.4 1.6 1.7 1 1 0 1 1 1 1 Flavoprotein Meth_synt_2 PF01717.18 EEA26948.1 - 1.9e-08 33.9 0.0 2.8e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Redoxin PF08534.10 EEA26949.1 - 4.8e-36 123.7 0.0 5.4e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EEA26949.1 - 3.8e-12 46.2 0.0 4.9e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF1348 PF07080.11 EEA26950.1 - 5.1e-58 194.6 3.6 5.9e-58 194.4 3.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EEA26950.1 - 3.6e-06 27.6 0.1 5.1e-06 27.1 0.1 1.4 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EEA26950.1 - 0.00019 21.8 0.1 0.00026 21.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.12 EEA26950.1 - 0.011 15.5 0.1 0.019 14.7 0.1 1.4 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase Pkinase PF00069.25 EEA26951.1 - 5.4e-67 225.9 0.0 3.6e-66 223.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Fungal_KA1 PF16797.5 EEA26951.1 - 2.7e-37 127.1 2.4 4.6e-37 126.3 0.3 2.2 2 0 0 2 2 2 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 EEA26951.1 - 1e-35 123.3 0.0 7.5e-34 117.2 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA26951.1 - 0.00043 20.3 0.1 0.016 15.2 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA26951.1 - 0.00056 18.9 0.0 0.0013 17.7 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA26951.1 - 0.0023 17.3 0.0 0.0053 16.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA26951.1 - 0.021 14.1 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 EEA26951.1 - 0.025 14.2 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase POP1 PF06978.11 EEA26952.1 - 1.4e-74 250.5 14.9 3e-74 249.5 14.9 1.6 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EEA26952.1 - 1.6e-34 118.1 0.7 9e-34 115.7 0.8 2.4 2 0 0 2 2 2 1 POPLD (NUC188) domain Nucleo_P87 PF07267.11 EEA26952.1 - 0.097 11.5 0.0 0.25 10.1 0.0 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF1690 PF07956.11 EEA26953.1 - 1.7e-40 138.6 8.8 1e-20 74.6 2.2 2.0 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) RPW8 PF05659.11 EEA26953.1 - 0.026 14.2 0.8 0.026 14.2 0.8 2.0 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF3040 PF11239.8 EEA26953.1 - 0.087 13.1 0.3 0.2 11.9 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Macoilin PF09726.9 EEA26953.1 - 0.11 11.0 4.4 0.025 13.2 1.3 1.4 2 0 0 2 2 2 0 Macoilin family Matrilin_ccoil PF10393.9 EEA26953.1 - 0.23 11.3 6.9 0.82 9.6 0.9 2.4 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin EF-G-binding_N PF07299.11 EEA26953.1 - 0.62 10.6 2.8 21 5.7 0.4 2.3 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal PP2C_C PF07830.13 EEA26953.1 - 0.96 9.9 3.0 10 6.6 0.9 2.3 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain HSCB_C PF07743.13 EEA26953.1 - 1.5 9.3 7.4 0.52 10.8 1.6 2.7 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain PET117 PF15786.5 EEA26953.1 - 2.3 8.6 6.6 0.57 10.5 0.2 2.3 2 0 0 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial Hexokinase_2 PF03727.16 EEA26954.1 - 4.4e-78 262.0 0.0 5.7e-78 261.7 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EEA26954.1 - 4.9e-74 248.5 0.0 8.7e-74 247.7 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Mpv17_PMP22 PF04117.12 EEA26955.1 - 4.3e-13 49.3 0.2 1.4e-12 47.6 0.0 2.0 1 1 1 2 2 2 1 Mpv17 / PMP22 family DUF3021 PF11457.8 EEA26955.1 - 3.4 8.0 8.6 0.47 10.8 2.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3021) p450 PF00067.22 EEA26956.1 - 2.1e-66 224.6 0.0 2.9e-66 224.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MitoNEET_N PF10660.9 EEA26956.1 - 0.095 12.7 0.7 0.21 11.6 0.2 1.9 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus Sdh_cyt PF01127.22 EEA26956.1 - 0.13 12.3 2.4 0.17 11.9 1.2 1.9 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit zf-C2HC5 PF06221.13 EEA26957.1 - 7.6e-22 77.1 7.8 1.2e-21 76.5 7.8 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type GST_C_3 PF14497.6 EEA26958.1 - 1.3e-18 67.0 0.0 2e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA26958.1 - 1.5e-06 28.4 0.0 3.1e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA26958.1 - 0.00075 19.9 0.0 0.0016 18.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA26958.1 - 0.0037 17.3 0.0 0.01 15.8 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA26958.1 - 0.015 15.5 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sgf11 PF08209.11 EEA26959.1 - 2.1e-13 49.6 0.9 2.1e-13 49.6 0.9 2.0 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) PRA-PH PF01503.17 EEA26959.1 - 0.075 13.5 0.9 0.19 12.2 0.9 1.7 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase Acetyltransf_1 PF00583.25 EEA26960.1 - 0.00074 19.7 0.0 0.014 15.6 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA26960.1 - 0.12 12.8 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RRN3 PF05327.11 EEA26960.1 - 1.3 7.5 5.2 1.8 7.0 5.2 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NAD_binding_6 PF08030.12 EEA26961.1 - 2.2e-20 73.4 0.0 1.8e-19 70.4 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EEA26961.1 - 1.5e-18 67.1 9.3 1.5e-18 67.1 9.3 2.5 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EEA26961.1 - 7.9e-12 45.2 0.0 2.9e-11 43.4 0.0 2.0 2 1 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EEA26961.1 - 0.00044 20.9 0.0 0.78 10.4 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF5621 PF18532.1 EEA26961.1 - 0.083 12.8 1.8 0.18 11.7 1.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5621) RNase_PH PF01138.21 EEA26962.1 - 5.9e-16 59.2 0.1 3.8e-15 56.5 0.1 2.2 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 Sporozoite_P67 PF05642.11 EEA26962.1 - 0.033 12.3 0.1 0.046 11.8 0.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 EEA26962.1 - 0.36 11.2 4.8 0.57 10.6 3.2 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RNA_pol_3_Rpc31 PF11705.8 EEA26962.1 - 0.99 9.6 5.2 1.7 8.8 5.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Peptidase_A22B PF04258.13 EEA26963.1 - 3.1e-61 207.4 5.0 1.3e-60 205.3 5.0 1.9 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 EEA26963.1 - 7.2e-07 29.0 2.4 7.2e-07 29.0 2.4 1.8 2 0 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease Pro_isomerase PF00160.21 EEA26964.1 - 2.3e-55 187.2 0.0 2.8e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3830 PF12903.7 EEA26964.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) GDI PF00996.18 EEA26965.1 - 2.9e-25 88.7 0.0 1.9e-24 86.0 0.0 1.9 1 1 0 1 1 1 1 GDP dissociation inhibitor DUF604 PF04646.12 EEA26966.1 - 7.8e-11 41.9 0.0 1.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Fringe PF02434.16 EEA26966.1 - 7.3e-05 22.3 0.0 0.00018 21.1 0.0 1.5 1 1 0 1 1 1 1 Fringe-like Fungal_trans PF04082.18 EEA26967.1 - 1.7e-12 47.0 0.3 3.6e-12 45.9 0.3 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA26967.1 - 6.8e-09 35.7 15.7 6.8e-09 35.7 15.7 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tetraspanin PF00335.20 EEA26968.1 - 4.9e-06 26.4 9.3 7.6e-06 25.8 9.3 1.3 1 0 0 1 1 1 1 Tetraspanin family DUF716 PF04819.12 EEA26968.1 - 0.7 9.5 5.8 2.2 7.9 5.7 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF716) Peptidase_U4 PF03419.13 EEA26968.1 - 2.3 7.4 6.6 3.7 6.7 3.3 2.3 2 1 0 2 2 2 0 Sporulation factor SpoIIGA SRF-TF PF00319.18 EEA26969.1 - 3.5e-21 74.4 0.1 5.1e-21 73.9 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Enkurin PF13864.6 EEA26969.1 - 0.056 13.9 0.1 0.14 12.6 0.1 1.6 1 0 0 1 1 1 0 Calmodulin-binding Mg_trans_NIPA PF05653.14 EEA26970.1 - 3.7e-15 55.8 13.9 2.4e-08 33.5 2.9 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EEA26970.1 - 9e-05 22.7 4.8 9e-05 22.7 4.8 2.9 3 1 0 3 3 3 1 EamA-like transporter family PUNUT PF16913.5 EEA26970.1 - 0.00049 19.4 0.9 0.00049 19.4 0.9 2.1 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport TMEM61 PF15105.6 EEA26970.1 - 0.082 12.7 0.4 0.22 11.4 0.1 1.8 2 0 0 2 2 2 0 TMEM61 protein family DUF4964 PF16334.5 EEA26970.1 - 0.14 11.7 0.1 0.38 10.3 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) Multi_Drug_Res PF00893.19 EEA26970.1 - 4.4 8.0 8.8 6 7.6 0.5 2.7 2 0 0 2 2 2 0 Small Multidrug Resistance protein DUF1206 PF06724.11 EEA26970.1 - 4.7 7.4 14.2 7.2 6.8 0.3 4.0 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1206) vATP-synt_E PF01991.18 EEA26971.1 - 6.9e-61 205.1 9.6 7.9e-61 204.9 9.6 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit EF-hand_11 PF08976.11 EEA26971.1 - 0.12 13.3 0.6 0.63 10.9 0.2 2.2 1 1 0 2 2 2 0 EF-hand domain Med3 PF11593.8 EEA26971.1 - 0.27 10.4 4.5 0.48 9.6 4.4 1.4 1 1 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4288 PF14119.6 EEA26971.1 - 0.32 11.4 2.9 8.6 6.8 0.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4288) Arylesterase PF01731.20 EEA26973.1 - 9e-06 25.8 0.1 1.9e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 Arylesterase PhoLip_ATPase_C PF16212.5 EEA26975.1 - 7.2e-81 271.6 25.2 7.2e-81 271.6 25.2 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA26975.1 - 7.7e-22 76.8 1.2 2.1e-21 75.4 1.2 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EEA26975.1 - 1.1e-10 41.4 0.0 8e-10 38.7 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EEA26975.1 - 1.1e-09 38.9 2.6 1.6e-05 25.3 0.3 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EEA26975.1 - 2.4e-05 23.9 0.0 0.00011 21.8 0.0 2.1 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EEA26975.1 - 0.027 14.2 0.2 0.072 12.8 0.2 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PhoLip_ATPase_C PF16212.5 EEA26976.1 - 6.4e-81 271.8 25.2 6.4e-81 271.8 25.2 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA26976.1 - 6.8e-22 76.9 1.2 1.9e-21 75.5 1.2 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EEA26976.1 - 9.7e-11 41.6 0.0 7.3e-10 38.8 0.0 2.4 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EEA26976.1 - 1.1e-09 38.9 2.9 1.5e-05 25.4 0.4 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EEA26976.1 - 2e-05 24.2 0.0 9.9e-05 21.9 0.0 2.2 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EEA26976.1 - 0.023 14.4 0.2 0.067 12.9 0.2 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SEN1_N PF12726.7 EEA26977.1 - 5.5e-214 712.7 6.7 7.3e-214 712.2 6.7 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EEA26977.1 - 8.8e-73 245.3 2.9 8.8e-73 245.3 2.9 2.8 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 EEA26977.1 - 5.1e-60 202.5 0.0 1e-59 201.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA26977.1 - 1.5e-10 41.2 0.2 1.6e-06 28.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 EEA26977.1 - 2.4e-09 37.1 3.6 1.2e-07 31.5 1.5 3.4 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EEA26977.1 - 3.1e-08 34.1 0.0 1.1e-07 32.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EEA26977.1 - 6.9e-07 29.2 0.1 0.034 13.9 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 EEA26977.1 - 0.00047 20.0 0.4 0.0012 18.7 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-CCHC PF00098.23 EEA26977.1 - 0.001 19.0 17.9 0.17 12.0 2.0 3.5 3 0 0 3 3 3 2 Zinc knuckle ResIII PF04851.15 EEA26977.1 - 0.01 15.8 0.0 0.045 13.8 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit T2SSE PF00437.20 EEA26977.1 - 0.011 14.8 0.1 0.022 13.8 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein CLIP1_ZNF PF16641.5 EEA26977.1 - 0.13 12.2 3.5 0.35 10.8 3.5 1.8 1 0 0 1 1 1 0 CLIP1 zinc knuckle RPN6_C_helix PF18503.1 EEA26977.1 - 0.15 11.8 0.0 0.4 10.5 0.0 1.8 1 0 0 1 1 1 0 26S proteasome subunit RPN6 C-terminal helix domain DUF4164 PF13747.6 EEA26977.1 - 0.15 12.4 8.2 0.085 13.1 4.7 2.6 2 1 0 2 2 1 0 Domain of unknown function (DUF4164) DUF3500 PF12006.8 EEA26979.1 - 1.5e-108 362.8 0.0 1.9e-108 362.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) fn3_2 PF16893.5 EEA26980.1 - 3.3e-37 126.5 0.0 5.4e-37 125.8 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EEA26980.1 - 1e-24 86.2 0.3 1.8e-24 85.4 0.3 1.5 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EEA26980.1 - 8e-14 51.3 0.0 1.3e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EEA26980.1 - 4.9e-10 39.7 0.0 9e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EEA26980.1 - 1.7e-06 28.3 0.0 3.3e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF3006 PF11213.8 EEA26980.1 - 6e-05 23.2 0.0 0.00021 21.5 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) fn3 PF00041.21 EEA26980.1 - 0.0072 16.6 0.0 0.029 14.7 0.0 2.0 1 1 0 1 1 1 1 Fibronectin type III domain Autophagy_act_C PF03987.15 EEA26981.1 - 0.07 13.7 0.0 0.23 12.1 0.0 1.9 2 1 0 2 2 2 0 Autophagocytosis associated protein, active-site domain Autophagy_act_C PF03987.15 EEA26982.1 - 0.07 13.7 0.0 0.23 12.1 0.0 1.9 2 1 0 2 2 2 0 Autophagocytosis associated protein, active-site domain eIF-1a PF01176.19 EEA26983.1 - 8.9e-23 79.9 0.1 1.3e-22 79.4 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 ERCC4 PF02732.15 EEA26984.1 - 3.4e-20 72.8 0.0 9.4e-20 71.4 0.0 1.8 1 0 0 1 1 1 1 ERCC4 domain DUF4780 PF16012.5 EEA26984.1 - 0.0046 16.4 0.0 6.4 6.2 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4780) HHH_5 PF14520.6 EEA26984.1 - 0.0058 17.2 0.0 0.015 15.8 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain Pkinase PF00069.25 EEA26985.1 - 1.8e-62 211.1 0.0 2.2e-62 210.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA26985.1 - 6.1e-29 101.1 0.0 9.1e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA26985.1 - 0.0022 17.0 0.2 0.0034 16.4 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Lambda_CIII PF02061.16 EEA26985.1 - 0.19 11.8 0.1 0.51 10.4 0.0 1.8 2 0 0 2 2 2 0 Lambda Phage CIII APH PF01636.23 EEA26985.1 - 0.2 11.6 0.0 0.68 9.8 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family zf-UBR PF02207.20 EEA26986.1 - 6.7e-14 51.8 5.0 6.7e-14 51.8 5.0 3.0 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) MCM PF00493.23 EEA26987.1 - 5.3e-101 336.4 0.0 8e-101 335.8 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA26987.1 - 9e-39 132.2 0.2 1.6e-38 131.4 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EEA26987.1 - 1.1e-28 100.5 36.5 1.1e-28 100.5 36.5 2.1 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EEA26987.1 - 9.1e-25 86.9 0.7 3.1e-24 85.2 0.7 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA26987.1 - 7.1e-11 42.6 0.0 2.2e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EEA26987.1 - 6.7e-09 35.4 0.1 3e-06 26.7 0.0 2.5 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EEA26987.1 - 4.6e-06 26.7 0.0 1.2e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EEA26987.1 - 0.00029 20.7 0.0 0.0013 18.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EEA26987.1 - 0.001 18.8 0.2 0.007 16.1 0.2 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 EEA26987.1 - 0.17 12.3 0.1 0.61 10.5 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA26987.1 - 0.28 11.6 0.0 0.28 11.6 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain Sugar_tr PF00083.24 EEA26988.1 - 4.3e-116 388.4 27.3 5e-116 388.2 27.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA26988.1 - 1.5e-22 80.0 32.6 1.3e-19 70.4 24.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EEA26989.1 - 9.1e-43 146.5 26.1 9.1e-43 146.5 26.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA26989.1 - 1.2e-13 50.7 3.5 1.2e-13 50.7 3.5 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter DDE_3 PF13358.6 EEA26990.1 - 7.4e-13 48.5 0.1 2.1e-12 47.0 0.1 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA26990.1 - 6.5e-10 39.1 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA26990.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA26990.1 - 0.0078 16.1 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA26990.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA26990.1 - 0.012 16.0 0.1 13 6.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA26990.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA26990.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA26990.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA26990.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA26990.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 SKG6 PF08693.10 EEA26991.1 - 1.3e-05 24.4 0.3 2.5e-05 23.6 0.3 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EEA26991.1 - 0.018 14.8 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF347 PF03988.12 EEA26991.1 - 0.019 15.1 0.7 0.048 13.9 0.7 1.6 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) VSP PF03302.13 EEA26991.1 - 0.021 13.7 0.3 0.029 13.2 0.3 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein PGF-CTERM PF18204.1 EEA26991.1 - 0.042 13.8 2.2 0.065 13.2 2.2 1.3 1 0 0 1 1 1 0 PGF-CTERM motif MGC-24 PF05283.11 EEA26991.1 - 0.67 10.4 6.2 1.1 9.7 6.2 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SSP160 PF06933.11 EEA26991.1 - 0.94 7.6 16.4 1.2 7.2 16.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF829 PF05705.14 EEA26992.1 - 4.7e-41 141.3 0.0 7.3e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) PAN_4 PF14295.6 EEA26992.1 - 0.00052 19.9 0.8 0.0012 18.7 0.8 1.6 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 EEA26992.1 - 0.0049 16.8 3.0 0.027 14.4 2.3 2.3 2 0 0 2 2 2 1 PAN domain Fringe PF02434.16 EEA26992.1 - 0.23 10.9 1.5 2 7.8 1.5 2.1 1 1 0 1 1 1 0 Fringe-like DUF829 PF05705.14 EEA26993.1 - 4.7e-41 141.3 0.0 7.3e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) PAN_4 PF14295.6 EEA26993.1 - 0.00052 19.9 0.8 0.0012 18.7 0.8 1.6 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 EEA26993.1 - 0.0049 16.8 3.0 0.027 14.4 2.3 2.3 2 0 0 2 2 2 1 PAN domain Fringe PF02434.16 EEA26993.1 - 0.23 10.9 1.5 2 7.8 1.5 2.1 1 1 0 1 1 1 0 Fringe-like CorA PF01544.18 EEA26994.1 - 4.8e-08 32.7 0.1 8.4e-08 31.9 0.1 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ApoL PF05461.11 EEA26994.1 - 0.055 12.8 0.1 0.1 11.9 0.1 1.5 1 0 0 1 1 1 0 Apolipoprotein L WH1 PF00568.23 EEA26995.1 - 3.1e-25 88.3 0.0 4.2e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EEA26995.1 - 0.0018 18.0 5.6 0.021 14.7 5.6 2.3 1 1 0 1 1 1 1 WH2 motif DUF1018 PF06252.12 EEA26995.1 - 0.065 14.2 0.3 0.28 12.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) Sugar_tr PF00083.24 EEA26997.1 - 3.4e-91 306.4 11.4 6e-91 305.6 11.4 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA26997.1 - 3.8e-37 128.0 59.0 7e-32 110.7 29.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EEA26997.1 - 4e-07 29.7 4.3 4e-07 29.7 4.3 3.0 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EEA26997.1 - 0.0013 17.3 2.1 0.0013 17.3 2.1 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EEA26997.1 - 0.06 11.6 5.1 0.05 11.9 1.6 2.5 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PS_Dcarbxylase PF02666.15 EEA26998.1 - 2.3e-56 190.5 0.0 4.5e-56 189.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EEA26998.1 - 1.7e-39 134.3 0.0 8e-19 67.9 0.0 2.5 2 0 0 2 2 2 2 C2 domain ORC_WH_C PF18137.1 EEA26998.1 - 0.14 12.3 1.6 0.3 11.2 1.6 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal EF-hand_6 PF13405.6 EEA26998.1 - 0.16 12.0 0.0 0.55 10.3 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain MIS13 PF08202.11 EEA26999.1 - 2e-51 175.1 0.1 4.6e-51 173.9 0.1 1.6 1 1 0 1 1 1 1 Mis12-Mtw1 protein family DivIC PF04977.15 EEA26999.1 - 0.073 12.8 0.4 0.17 11.7 0.4 1.6 1 0 0 1 1 1 0 Septum formation initiator Takusan PF04822.13 EEA26999.1 - 0.1 12.5 1.0 0.36 10.7 1.0 1.9 1 0 0 1 1 1 0 Takusan pPIWI_RE_Y PF18156.1 EEA26999.1 - 0.78 10.2 4.5 1 9.8 0.1 3.1 3 0 0 3 3 3 0 pPIWI_RE three-gene island domain Y ThrE PF06738.12 EEA27000.1 - 1.8e-72 243.6 18.5 6.7e-69 231.9 2.4 2.7 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EEA27000.1 - 3.5e-09 36.9 10.6 3.5e-09 36.9 10.6 3.3 3 1 0 3 3 3 1 Threonine/Serine exporter, ThrE GATA PF00320.27 EEA27001.1 - 3e-15 55.5 5.3 5.4e-15 54.7 5.3 1.4 1 0 0 1 1 1 1 GATA zinc finger 5-nucleotidase PF06189.12 EEA27001.1 - 0.19 10.6 0.1 0.28 10.1 0.1 1.1 1 0 0 1 1 1 0 5'-nucleotidase zinc_ribbon_9 PF14369.6 EEA27001.1 - 0.4 11.0 1.6 0.8 10.0 1.6 1.5 1 0 0 1 1 1 0 zinc-ribbon GATA PF00320.27 EEA27002.1 - 3e-15 55.5 5.3 5.4e-15 54.7 5.3 1.4 1 0 0 1 1 1 1 GATA zinc finger 5-nucleotidase PF06189.12 EEA27002.1 - 0.19 10.6 0.1 0.28 10.1 0.1 1.1 1 0 0 1 1 1 0 5'-nucleotidase zinc_ribbon_9 PF14369.6 EEA27002.1 - 0.4 11.0 1.6 0.8 10.0 1.6 1.5 1 0 0 1 1 1 0 zinc-ribbon GATA PF00320.27 EEA27003.1 - 3e-15 55.5 5.3 5.4e-15 54.7 5.3 1.4 1 0 0 1 1 1 1 GATA zinc finger 5-nucleotidase PF06189.12 EEA27003.1 - 0.19 10.6 0.1 0.28 10.1 0.1 1.1 1 0 0 1 1 1 0 5'-nucleotidase zinc_ribbon_9 PF14369.6 EEA27003.1 - 0.4 11.0 1.6 0.8 10.0 1.6 1.5 1 0 0 1 1 1 0 zinc-ribbon GCS PF03074.16 EEA27004.1 - 3.7e-177 589.2 0.0 4.6e-177 588.9 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase Cytochrom_B561 PF03188.16 EEA27004.1 - 0.24 11.5 0.0 5.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 NDUF_B7 PF05676.13 EEA27005.1 - 7.1e-30 102.5 6.2 8.6e-30 102.3 6.2 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 EEA27005.1 - 0.0082 16.1 1.0 0.011 15.7 1.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Ank_4 PF13637.6 EEA27006.1 - 1.4e-11 44.7 0.2 4.8e-05 23.8 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA27006.1 - 6.2e-10 39.1 0.1 7.7e-07 29.3 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EEA27006.1 - 3.8e-09 37.0 0.0 9.4e-05 22.9 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA27006.1 - 1.4e-08 34.3 0.2 0.00015 21.9 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EEA27006.1 - 2.8e-07 30.7 0.2 0.00012 22.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) KilA-N PF04383.13 EEA27006.1 - 4.6e-05 23.2 0.0 0.00022 21.0 0.0 2.1 1 1 0 1 1 1 1 KilA-N domain Macro PF01661.21 EEA27008.1 - 3e-40 136.9 0.0 4.6e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 Macro domain Peptidase_S24 PF00717.23 EEA27009.1 - 3.3e-07 30.1 0.0 1.5e-06 28.1 0.0 2.1 2 1 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 EEA27009.1 - 0.0024 17.7 0.1 3.7 7.3 0.0 2.8 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 PH_4 PF15404.6 EEA27010.1 - 1.3e-54 184.8 3.7 2.8e-54 183.7 0.4 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.6 EEA27010.1 - 3.8e-23 80.9 2.9 3.8e-23 80.9 2.9 2.5 3 0 0 3 3 3 1 Sporulation protein family 7 PH PF00169.29 EEA27010.1 - 2.6e-10 40.7 5.5 0.0025 18.3 0.0 5.5 5 1 0 5 5 5 4 PH domain PH_6 PF15406.6 EEA27010.1 - 0.016 15.5 0.0 1.2 9.4 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain GLTP PF08718.11 EEA27011.1 - 1.6e-43 148.6 0.1 2.4e-43 148.0 0.1 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) ZapD PF07072.11 EEA27011.1 - 0.052 13.3 0.1 0.086 12.6 0.1 1.3 1 0 0 1 1 1 0 Cell division protein JIP_LZII PF16471.5 EEA27011.1 - 0.072 13.3 0.6 0.18 12.0 0.2 1.9 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II E1-E2_ATPase PF00122.20 EEA27012.1 - 3e-19 69.2 0.0 6.7e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EEA27012.1 - 2e-13 51.1 2.3 1.9e-07 31.6 1.6 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA27012.1 - 0.00027 21.0 0.0 0.0075 16.3 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA27012.1 - 0.0035 17.1 0.2 0.022 14.5 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EEA27012.1 - 0.016 14.7 0.1 0.047 13.2 0.0 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase HMG_box PF00505.19 EEA27013.1 - 2e-23 82.6 0.1 2.9e-23 82.1 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA27013.1 - 1.6e-15 57.4 0.1 2.7e-15 56.7 0.1 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 EEA27013.1 - 0.13 12.8 0.2 0.2 12.2 0.2 1.3 1 0 0 1 1 1 0 YABBY protein HMG_box PF00505.19 EEA27014.1 - 2e-23 82.6 0.1 2.9e-23 82.1 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA27014.1 - 1.6e-15 57.4 0.1 2.7e-15 56.7 0.1 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 EEA27014.1 - 0.13 12.8 0.2 0.2 12.2 0.2 1.3 1 0 0 1 1 1 0 YABBY protein CENP-H PF05837.12 EEA27015.1 - 1.1e-30 106.4 3.6 1.1e-30 106.4 3.6 2.1 2 0 0 2 2 2 1 Centromere protein H (CENP-H) Tom5 PF10642.9 EEA27015.1 - 0.15 12.1 2.3 0.31 11.1 0.2 2.6 2 1 1 3 3 3 0 Mitochondrial import receptor subunit or translocase DinB PF05163.12 EEA27015.1 - 0.39 10.6 4.0 0.21 11.5 0.2 2.0 2 0 0 2 2 2 0 DinB family AAA_23 PF13476.6 EEA27015.1 - 5.3 7.5 9.5 4.2 7.8 3.8 2.1 2 0 0 2 2 2 0 AAA domain ATG11 PF10377.9 EEA27016.1 - 1.3e-44 151.4 0.1 1.3e-44 151.4 0.1 4.5 4 1 0 4 4 4 1 Autophagy-related protein 11 APG17 PF04108.12 EEA27016.1 - 2.7e-07 30.1 1.7 1.6e-05 24.2 0.2 5.2 2 2 1 3 3 3 2 Autophagy protein Apg17 Transthyretin PF00576.21 EEA27017.1 - 2.7e-27 95.6 0.0 7.1e-26 91.1 0.0 2.2 1 1 0 1 1 1 1 HIUase/Transthyretin family MitoNEET_N PF10660.9 EEA27017.1 - 0.11 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus ArsA_ATPase PF02374.15 EEA27018.1 - 5.3e-116 387.1 0.0 6e-116 386.9 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EEA27018.1 - 1.2e-13 51.4 0.3 1.6e-12 47.7 0.0 2.5 2 2 0 2 2 2 1 AAA domain CbiA PF01656.23 EEA27018.1 - 1e-12 48.2 0.0 2.3e-12 47.1 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EEA27018.1 - 6.4e-06 25.8 0.1 1.4e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 EEA27018.1 - 1.4e-05 24.8 0.1 0.00065 19.4 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain ParA PF10609.9 EEA27018.1 - 2.2e-05 24.1 1.3 0.00018 21.0 0.1 2.3 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 EEA27018.1 - 5.9e-05 22.7 0.1 0.00023 20.7 0.0 1.9 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_16 PF13191.6 EEA27018.1 - 0.019 15.3 0.0 0.034 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 EEA27018.1 - 0.033 13.6 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein NB-ARC PF00931.22 EEA27018.1 - 0.099 11.8 0.0 0.24 10.6 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 EEA27018.1 - 0.12 11.9 0.0 0.51 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain eIF3_N PF09440.10 EEA27021.1 - 2.3e-50 170.5 1.1 7.2e-50 168.9 1.1 1.9 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EEA27021.1 - 3.8e-14 53.1 0.0 9.6e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 PCI domain Img2 PF05046.14 EEA27022.1 - 7.9e-28 96.6 0.0 1.5e-27 95.7 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.22 EEA27022.1 - 0.019 15.5 0.1 0.044 14.3 0.1 1.7 1 0 0 1 1 1 0 Translation initiation factor SUI1 LAMTOR5 PF16672.5 EEA27022.1 - 0.14 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 ARID PF01388.21 EEA27023.1 - 4.6e-20 72.1 0.0 1.1e-19 70.9 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain AAA PF00004.29 EEA27024.1 - 7.1e-45 152.7 0.6 2.4e-44 151.0 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EEA27024.1 - 2.4e-10 40.2 0.2 2.1e-09 37.2 0.0 2.5 3 0 0 3 3 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EEA27024.1 - 2e-08 34.3 0.1 7.4e-08 32.5 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA27024.1 - 1.1e-07 32.2 0.0 2.3e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA27024.1 - 1.5e-07 32.0 0.4 3e-05 24.5 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EEA27024.1 - 3.1e-06 26.5 0.0 7.2e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EEA27024.1 - 4.8e-05 23.6 0.8 0.0081 16.4 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 EEA27024.1 - 0.00019 21.2 0.0 0.00045 20.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EEA27024.1 - 0.00036 20.3 0.0 0.001 18.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EEA27024.1 - 0.00053 19.5 0.0 0.007 15.9 0.1 2.5 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 EEA27024.1 - 0.00065 20.2 0.0 0.0021 18.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EEA27024.1 - 0.00066 19.7 0.0 0.0024 17.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EEA27024.1 - 0.00074 19.8 0.1 0.002 18.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 EEA27024.1 - 0.0014 19.0 0.0 0.0031 17.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 EEA27024.1 - 0.0026 17.7 0.0 0.013 15.4 0.0 2.1 2 0 0 2 2 2 1 NTPase AAA_30 PF13604.6 EEA27024.1 - 0.0036 17.1 0.2 0.011 15.5 0.2 1.9 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EEA27024.1 - 0.0042 17.1 0.0 0.011 15.7 0.0 1.7 1 1 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 EEA27024.1 - 0.005 16.1 0.0 0.0092 15.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EEA27024.1 - 0.0058 16.8 0.0 0.021 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EEA27024.1 - 0.0066 16.3 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EEA27024.1 - 0.007 15.8 0.0 0.36 10.2 0.0 2.4 2 0 0 2 2 2 1 Bacterial TniB protein Mg_chelatase PF01078.21 EEA27024.1 - 0.0084 15.5 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EEA27024.1 - 0.0094 15.7 0.1 0.034 13.9 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein NACHT PF05729.12 EEA27024.1 - 0.013 15.4 1.2 0.11 12.4 0.0 2.7 3 1 0 3 3 3 0 NACHT domain AAA_24 PF13479.6 EEA27024.1 - 0.021 14.6 0.2 0.051 13.3 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EEA27024.1 - 0.043 13.6 0.1 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EEA27024.1 - 0.044 13.7 0.7 0.22 11.4 0.1 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EEA27024.1 - 0.065 12.8 1.0 0.3 10.6 0.1 2.2 2 1 1 3 3 3 0 AAA domain Bac_DnaA PF00308.18 EEA27024.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein Sigma54_activat PF00158.26 EEA27024.1 - 0.12 12.1 0.1 1.3 8.7 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EEA27024.1 - 0.14 12.5 0.1 0.39 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EEA27024.1 - 0.21 10.6 0.0 0.39 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA PF00004.29 EEA27025.1 - 5.1e-45 153.1 0.1 1.4e-44 151.7 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EEA27025.1 - 1.6e-09 37.5 0.2 1.1e-08 34.9 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EEA27025.1 - 1.6e-08 34.6 0.1 4.5e-08 33.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA27025.1 - 7.3e-08 32.7 0.0 1.4e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA27025.1 - 1.1e-07 32.4 0.1 2.1e-05 25.0 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EEA27025.1 - 2.4e-06 26.9 0.0 4e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EEA27025.1 - 3.2e-05 24.2 0.9 0.0061 16.8 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 EEA27025.1 - 0.00014 21.6 0.0 0.00032 20.5 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EEA27025.1 - 0.00023 20.9 0.0 0.00065 19.5 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EEA27025.1 - 0.00066 20.2 0.0 0.0012 19.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EEA27025.1 - 0.00068 19.7 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EEA27025.1 - 0.00074 19.1 0.1 0.0042 16.6 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_28 PF13521.6 EEA27025.1 - 0.00075 19.8 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EEA27025.1 - 0.00097 19.5 0.0 0.002 18.5 0.0 1.5 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 EEA27025.1 - 0.0013 18.6 0.0 0.0082 16.1 0.0 2.2 2 0 0 2 2 2 1 NTPase AAA_30 PF13604.6 EEA27025.1 - 0.0026 17.5 0.3 0.0078 15.9 0.3 1.9 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EEA27025.1 - 0.0027 17.7 0.0 0.0075 16.3 0.0 1.7 1 1 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 EEA27025.1 - 0.0032 16.7 0.0 0.0055 16.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain TniB PF05621.11 EEA27025.1 - 0.0041 16.6 0.0 0.26 10.7 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein NACHT PF05729.12 EEA27025.1 - 0.0047 16.9 0.3 0.083 12.8 0.0 2.6 3 0 0 3 3 2 1 NACHT domain AAA_3 PF07726.11 EEA27025.1 - 0.0048 16.8 0.0 0.014 15.2 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EEA27025.1 - 0.0058 16.0 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EEA27025.1 - 0.0079 16.4 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EEA27025.1 - 0.013 15.2 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EEA27025.1 - 0.016 15.0 0.2 0.035 13.8 0.2 1.7 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA27025.1 - 0.025 14.5 0.1 0.22 11.4 0.0 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 EEA27025.1 - 0.047 13.5 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_11 PF13086.6 EEA27025.1 - 0.052 13.3 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EEA27025.1 - 0.054 13.1 0.4 0.19 11.3 0.1 1.8 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EEA27025.1 - 0.074 12.7 0.1 0.91 9.2 0.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EEA27025.1 - 0.11 12.8 0.2 0.28 11.5 0.1 1.7 2 0 0 2 2 1 0 AAA domain ATPase PF06745.13 EEA27025.1 - 0.12 11.7 0.0 0.62 9.4 0.0 1.9 2 0 0 2 2 2 0 KaiC cobW PF02492.19 EEA27025.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Parvo_NS1 PF01057.17 EEA27025.1 - 0.17 10.9 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Asp PF00026.23 EEA27026.1 - 4.5e-109 364.7 0.1 5.3e-109 364.4 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA27026.1 - 6e-17 62.4 2.0 5.5e-15 56.1 1.5 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA27026.1 - 2.2e-06 28.2 0.2 0.056 14.1 0.0 3.2 3 1 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EEA27026.1 - 0.00012 22.6 0.0 0.14 12.7 0.0 2.8 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EEA27026.1 - 0.016 15.0 0.0 0.25 11.1 0.0 2.3 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal MARVEL PF01284.23 EEA27027.1 - 0.0002 21.4 15.7 0.00037 20.5 15.7 1.5 1 1 0 1 1 1 1 Membrane-associating domain Papilloma_E5A PF05776.12 EEA27027.1 - 0.037 14.4 2.1 0.075 13.4 2.1 1.5 1 0 0 1 1 1 0 Papillomavirus E5A protein MARVEL PF01284.23 EEA27028.1 - 0.0002 21.4 15.7 0.00037 20.5 15.7 1.5 1 1 0 1 1 1 1 Membrane-associating domain Papilloma_E5A PF05776.12 EEA27028.1 - 0.037 14.4 2.1 0.075 13.4 2.1 1.5 1 0 0 1 1 1 0 Papillomavirus E5A protein MT0933_antitox PF14013.6 EEA27029.1 - 0.02 15.2 0.3 0.061 13.6 0.3 1.9 1 1 0 1 1 1 0 MT0933-like antitoxin protein NIF PF03031.18 EEA27030.1 - 2.6e-27 95.5 0.2 8e-27 93.9 0.0 1.8 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EEA27030.1 - 1.6e-07 31.6 0.0 3.7e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EEA27030.1 - 0.00037 20.4 0.1 0.00085 19.2 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EEA27030.1 - 0.00047 20.5 0.0 0.0022 18.4 0.0 2.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EEA27030.1 - 0.076 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Biotin_lipoyl_2 PF13533.6 EEA27030.1 - 0.12 12.2 0.0 4.5 7.2 0.0 2.5 2 0 0 2 2 2 0 Biotin-lipoyl like UPF0242 PF06785.11 EEA27030.1 - 3.6 7.7 7.3 7.7 6.6 7.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Arginase PF00491.21 EEA27031.1 - 3.2e-78 263.1 0.5 3.7e-78 262.9 0.5 1.0 1 0 0 1 1 1 1 Arginase family GatB_N PF02934.15 EEA27032.1 - 1.1e-97 326.7 0.0 1.5e-97 326.3 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EEA27032.1 - 3.2e-26 92.0 0.7 5.9e-26 91.1 0.7 1.4 1 0 0 1 1 1 1 GatB domain DUF3512 PF12024.8 EEA27034.1 - 0.0017 17.9 0.1 0.0048 16.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) ECH_1 PF00378.20 EEA27036.1 - 2.5e-41 141.7 0.0 4.9e-41 140.7 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA27036.1 - 1.8e-30 106.6 0.0 2.3e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NB-ARC PF00931.22 EEA27037.1 - 3.1e-11 43.0 0.0 4.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EEA27037.1 - 6.2e-06 26.7 0.0 1.5e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA27037.1 - 1.2e-05 25.6 0.0 2.9e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EEA27037.1 - 0.00014 21.2 0.0 0.00028 20.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin RuvB_N PF05496.12 EEA27037.1 - 0.0012 18.6 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EEA27037.1 - 0.0019 18.2 0.0 0.0046 16.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 EEA27037.1 - 0.012 15.8 0.0 0.031 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA27037.1 - 0.022 14.5 0.0 0.062 13.0 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase PF06745.13 EEA27037.1 - 0.045 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 EEA27037.1 - 0.075 13.6 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA27037.1 - 0.098 13.0 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EEA27037.1 - 0.15 11.5 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 EEA27037.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA27037.1 - 0.2 11.5 0.0 0.61 10.0 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF676 PF05057.14 EEA27038.1 - 2.9e-05 23.7 0.0 7.5e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EEA27038.1 - 0.0014 18.4 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EEA27038.1 - 0.0015 19.2 0.0 0.0019 18.9 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA27038.1 - 0.13 11.5 0.0 0.65 9.2 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 FHA PF00498.26 EEA27040.1 - 2.7e-14 53.3 0.0 7.2e-14 51.9 0.0 1.8 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EEA27040.1 - 0.074 13.4 0.0 1.6 9.1 0.0 2.3 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain DnaJ PF00226.31 EEA27041.1 - 2.1e-09 37.4 2.0 2.1e-09 37.4 2.0 1.8 2 0 0 2 2 2 1 DnaJ domain ABC_tran PF00005.27 EEA27042.1 - 1.3e-52 178.0 0.2 1.7e-26 93.4 0.1 2.3 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 EEA27042.1 - 1e-45 155.8 37.9 1.3e-26 93.3 10.8 2.7 3 0 0 3 3 2 2 ABC-2 type transporter AAA_21 PF13304.6 EEA27042.1 - 3.6e-13 50.0 3.1 9.7e-05 22.3 0.1 4.3 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA27042.1 - 1.3e-09 38.2 0.5 0.00099 19.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 EEA27042.1 - 6.8e-09 35.5 1.0 0.044 13.2 0.1 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA27042.1 - 4.2e-08 33.8 0.1 0.003 17.9 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EEA27042.1 - 8.7e-08 32.9 0.4 0.00095 19.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EEA27042.1 - 4e-06 26.5 3.0 0.041 13.6 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA27042.1 - 9.1e-06 26.0 0.1 0.091 13.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 EEA27042.1 - 4.4e-05 23.1 0.9 0.28 10.8 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EEA27042.1 - 5.3e-05 23.0 0.2 0.25 11.0 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EEA27042.1 - 9.4e-05 22.1 0.2 0.82 9.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 EEA27042.1 - 0.00016 21.6 0.1 0.13 12.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain T2SSE PF00437.20 EEA27042.1 - 0.00018 20.6 0.5 0.018 14.1 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein ATPase_2 PF01637.18 EEA27042.1 - 0.00049 20.1 0.1 0.034 14.1 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EEA27042.1 - 0.00054 20.3 0.6 0.18 12.2 0.1 2.6 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.23 EEA27042.1 - 0.0013 18.8 2.8 0.48 10.5 0.4 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA PF00004.29 EEA27042.1 - 0.0014 19.0 0.2 0.74 10.2 0.0 2.9 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EEA27042.1 - 0.0017 18.5 0.9 0.66 10.2 0.1 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EEA27042.1 - 0.0019 18.2 0.2 0.82 9.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EEA27042.1 - 0.0021 18.6 0.0 0.29 11.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EEA27042.1 - 0.0024 17.6 0.1 2.7 7.6 0.1 2.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 EEA27042.1 - 0.0036 17.1 0.1 2.4 7.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA27042.1 - 0.004 17.3 0.1 0.62 10.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EEA27042.1 - 0.0062 16.8 2.0 0.75 10.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain PDR_CDR PF06422.12 EEA27042.1 - 0.0078 16.1 0.1 0.041 13.8 0.1 2.2 1 0 0 1 1 1 1 CDR ABC transporter AAA_19 PF13245.6 EEA27042.1 - 0.008 16.5 0.3 7.2 6.9 0.0 2.9 3 0 0 3 3 2 0 AAA domain ATP-synt_ab PF00006.25 EEA27042.1 - 0.02 14.6 0.1 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 EEA27042.1 - 0.023 14.2 0.6 4.7 6.7 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EEA27042.1 - 0.031 14.3 0.1 7.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DnaB_C PF03796.15 EEA27042.1 - 0.041 13.2 0.3 0.23 10.7 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain MobB PF03205.14 EEA27042.1 - 0.041 13.8 0.5 6.4 6.7 0.1 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.14 EEA27042.1 - 0.043 13.1 0.0 4.2 6.5 0.0 2.3 2 0 0 2 2 2 0 KAP family P-loop domain NTPase_1 PF03266.15 EEA27042.1 - 0.052 13.5 0.4 9 6.2 0.0 2.9 3 0 0 3 3 3 0 NTPase AAA_35 PF14516.6 EEA27042.1 - 0.057 12.2 0.2 1.4 7.7 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain Zeta_toxin PF06414.12 EEA27042.1 - 0.063 12.6 0.9 7.2 5.8 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin PIF1 PF05970.14 EEA27042.1 - 0.072 12.2 0.4 10 5.1 0.0 2.7 3 0 0 3 3 3 0 PIF1-like helicase PduV-EutP PF10662.9 EEA27042.1 - 0.092 12.5 0.4 15 5.3 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PRK PF00485.18 EEA27042.1 - 0.093 12.5 1.6 5.2 6.7 0.2 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ATP_bind_1 PF03029.17 EEA27042.1 - 0.12 12.1 1.2 14 5.4 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Pox_A32 PF04665.12 EEA27042.1 - 0.13 11.7 1.6 7.4 5.9 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_11 PF13086.6 EEA27042.1 - 0.14 11.9 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 EEA27042.1 - 0.15 11.5 0.4 9.5 5.6 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit SbcCD_C PF13558.6 EEA27042.1 - 0.16 12.3 0.4 10 6.4 0.1 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PhoH PF02562.16 EEA27042.1 - 0.17 11.3 0.1 15 5.0 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Rad17 PF03215.15 EEA27042.1 - 0.19 11.6 0.0 10 6.0 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain Dynamin_N PF00350.23 EEA27042.1 - 0.21 11.6 3.1 9.2 6.3 0.4 2.6 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 EEA27042.1 - 0.29 10.4 1.4 5.2 6.3 0.2 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Gtr1_RagA PF04670.12 EEA27042.1 - 0.58 9.5 2.2 21 4.3 0.2 2.5 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region DUF87 PF01935.17 EEA27042.1 - 2.2 8.3 4.1 6.3 6.8 0.6 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain DUF2627 PF11118.8 EEA27042.1 - 5.3 7.7 13.6 1.3 9.6 0.0 4.4 4 0 0 4 4 3 0 Protein of unknown function (DUF2627) Abhydrolase_3 PF07859.13 EEA27044.1 - 1e-39 136.6 0.1 6.4e-39 134.0 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EEA27044.1 - 1.4e-06 27.5 0.0 1.6e-05 23.9 0.0 2.1 1 1 0 1 1 1 1 Steryl acetyl hydrolase PGA_cap PF09587.10 EEA27044.1 - 0.093 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap BTB PF00651.31 EEA27046.1 - 7.3e-08 32.6 0.1 5.1e-07 29.9 0.0 2.3 3 0 0 3 3 3 1 BTB/POZ domain Skp1_POZ PF03931.15 EEA27046.1 - 0.0094 16.1 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain DUF2752 PF10825.8 EEA27047.1 - 0.035 14.1 0.6 0.059 13.4 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) CRF1 PF10380.9 EEA27048.1 - 0.028 14.7 0.2 0.028 14.7 0.2 3.1 4 0 0 4 4 4 0 Transcription factor CRF1 CFEM PF05730.11 EEA27049.1 - 0.00013 22.0 7.9 0.00013 22.0 7.9 2.9 2 0 0 2 2 2 1 CFEM domain DUF3433 PF11915.8 EEA27050.1 - 5.2e-41 139.0 7.1 1.1e-23 83.5 0.9 3.8 5 0 0 5 5 5 2 Protein of unknown function (DUF3433) DUF4718 PF15842.5 EEA27050.1 - 0.12 12.2 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) DUF3995 PF13160.6 EEA27050.1 - 0.2 12.0 0.1 0.2 12.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3995) Sds3 PF08598.11 EEA27052.1 - 1.3e-47 162.6 1.7 2.2e-44 152.1 0.0 2.1 1 1 1 2 2 2 2 Sds3-like UL42 PF17638.2 EEA27053.1 - 6 6.9 8.7 0.76 9.8 2.0 2.6 3 0 0 3 3 3 0 HCMV UL42 Glyco_hydro_72 PF03198.14 EEA27055.1 - 3.6e-101 338.6 0.7 4.9e-101 338.1 0.7 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 EEA27055.1 - 0.081 12.0 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Pkinase PF00069.25 EEA27056.1 - 8e-13 48.3 0.0 4.4e-10 39.4 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27056.1 - 1.9e-09 37.2 0.0 2e-08 33.8 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase SR-25 PF10500.9 EEA27056.1 - 0.0025 17.4 0.6 0.0025 17.4 0.6 2.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Nucleo_P87 PF07267.11 EEA27056.1 - 1.6 7.5 10.0 2.6 6.8 10.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AT_hook PF02178.19 EEA27057.1 - 0.31 11.0 16.6 0.43 10.6 4.1 3.0 2 0 0 2 2 2 0 AT hook motif Aldose_epim PF01263.20 EEA27058.1 - 1.4e-48 165.8 0.2 1.8e-48 165.4 0.2 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase SusE PF14292.6 EEA27058.1 - 0.032 14.4 0.0 12 6.1 0.0 3.2 2 1 1 3 3 3 0 SusE outer membrane protein FTA2 PF13095.6 EEA27059.1 - 0.018 14.7 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Actin PF00022.19 EEA27061.1 - 2.1e-25 89.2 0.0 1e-16 60.6 0.0 2.5 3 0 0 3 3 3 2 Actin MreB_Mbl PF06723.13 EEA27061.1 - 0.00091 18.1 0.0 0.0097 14.8 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein XPG_I PF00867.18 EEA27062.1 - 3.5e-24 85.0 0.0 8.6e-24 83.7 0.0 1.7 1 0 0 1 1 1 1 XPG I-region GEN1_C PF18380.1 EEA27062.1 - 5.2e-23 81.9 0.1 5.2e-23 81.9 0.1 3.0 2 2 1 3 3 3 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 EEA27062.1 - 6.2e-07 29.8 0.0 1.6e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain Rpn9_C PF18261.1 EEA27062.1 - 0.24 11.0 1.4 0.28 10.8 0.1 1.8 2 0 0 2 2 2 0 Rpn9 C-terminal helix CTP_transf_1 PF01148.20 EEA27063.1 - 0.00019 21.3 2.2 0.0003 20.7 2.2 1.3 1 1 0 1 1 1 1 Cytidylyltransferase family DEAD PF00270.29 EEA27064.1 - 6.2e-38 130.3 0.0 2.7e-37 128.2 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA27064.1 - 8.9e-23 80.8 0.0 2.2e-22 79.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA27064.1 - 8.7e-21 73.9 0.1 1.7e-20 73.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EEA27064.1 - 0.0039 17.2 0.0 0.014 15.4 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA27064.1 - 0.022 13.9 0.0 0.055 12.7 0.0 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UvrD-helicase PF00580.21 EEA27064.1 - 0.2 11.1 2.6 2 7.9 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_11 PF13086.6 EEA27064.1 - 2.6 7.8 5.2 6.5 6.4 4.2 2.2 2 0 0 2 2 2 0 AAA domain Ribosomal_S15 PF00312.22 EEA27067.1 - 2.9e-27 94.7 4.7 4.9e-27 94.0 0.4 2.9 2 1 1 3 3 3 1 Ribosomal protein S15 Ribosomal_S2 PF00318.20 EEA27068.1 - 3e-26 92.0 0.1 8.6e-15 54.6 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EEA27068.1 - 7e-08 33.7 14.0 1.3e-07 32.9 14.0 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ras PF00071.22 EEA27069.1 - 9.7e-21 74.0 0.0 1.6e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA27069.1 - 1.4e-05 25.3 0.0 3.5e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA27069.1 - 0.00066 19.2 0.0 0.0072 15.8 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 EEA27069.1 - 0.0034 17.1 0.0 0.0042 16.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EEA27069.1 - 0.0049 16.8 0.0 0.0085 16.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EEA27069.1 - 0.006 16.8 0.0 0.0083 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA27069.1 - 0.011 16.2 0.1 0.012 16.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EEA27069.1 - 0.023 15.2 0.0 0.066 13.7 0.0 1.3 1 1 0 1 1 1 0 ABC transporter Viral_helicase1 PF01443.18 EEA27069.1 - 0.03 14.0 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase G-alpha PF00503.20 EEA27069.1 - 0.032 13.4 0.0 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit RNA_helicase PF00910.22 EEA27069.1 - 0.034 14.5 0.0 0.11 12.9 0.0 1.8 1 1 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 EEA27069.1 - 0.082 12.9 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.18 EEA27069.1 - 0.16 11.2 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Septin AAA PF00004.29 EEA27069.1 - 0.17 12.3 0.1 0.41 11.1 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EEA27069.1 - 0.2 11.6 0.0 0.29 11.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain PseudoU_synth_1 PF01416.20 EEA27070.1 - 5.5e-35 120.1 0.0 8e-34 116.3 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase Pox_A_type_inc PF04508.12 EEA27070.1 - 0.032 14.1 0.1 0.081 12.8 0.1 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat PIG-H PF10181.9 EEA27071.1 - 4.2e-27 93.8 1.1 6e-27 93.3 0.4 1.6 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component RBP_receptor PF14752.6 EEA27071.1 - 0.082 11.5 0.0 0.094 11.3 0.0 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor PIG-H PF10181.9 EEA27072.1 - 3.1e-27 94.2 1.1 4.7e-27 93.7 0.4 1.6 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component ubiquitin PF00240.23 EEA27073.1 - 0.002 17.9 0.0 0.003 17.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.10 EEA27073.1 - 0.002 18.8 0.0 0.0034 18.0 0.0 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD YukD PF08817.10 EEA27074.1 - 0.002 18.8 0.0 0.0032 18.1 0.0 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 EEA27074.1 - 0.0041 16.9 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Pribosyl_synth PF14572.6 EEA27075.1 - 5.4e-41 140.7 1.8 2.7e-35 122.0 0.7 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EEA27075.1 - 4e-34 117.0 0.0 1.2e-33 115.5 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EEA27075.1 - 4.3e-14 52.3 0.3 9.8e-14 51.2 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EEA27075.1 - 0.00046 19.7 0.2 0.00077 19.0 0.2 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase vATP-synt_AC39 PF01992.16 EEA27076.1 - 2e-105 353.0 0.0 2.2e-105 352.9 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Nop PF01798.18 EEA27077.1 - 5.6e-83 277.9 0.3 5.6e-83 277.9 0.3 1.6 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EEA27077.1 - 1.8e-22 79.5 1.1 1.8e-22 79.5 1.1 2.5 2 0 0 2 2 2 1 NOP5NT (NUC127) domain DUF5531 PF17671.1 EEA27077.1 - 2.6 7.9 5.6 5.4 6.9 5.4 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5531) RNA_pol_Rpb4 PF03874.16 EEA27078.1 - 5.3e-08 33.2 0.4 0.001 19.4 0.0 2.3 2 1 0 2 2 2 2 RNA polymerase Rpb4 TMF_DNA_bd PF12329.8 EEA27080.1 - 1.9 8.5 7.2 3.2 7.8 0.7 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding PARP PF00644.20 EEA27081.1 - 2.9e-13 49.8 0.9 8.6e-13 48.3 0.9 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 EEA27081.1 - 5.7e-07 29.3 0.0 1.7e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Band_7 PF01145.25 EEA27082.1 - 4.8e-26 91.8 3.0 8.2e-26 91.1 3.0 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EEA27082.1 - 0.032 13.9 0.2 0.051 13.3 0.2 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Perilipin PF03036.16 EEA27083.1 - 0.013 14.6 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 0 Perilipin family Perilipin PF03036.16 EEA27084.1 - 0.013 14.6 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 0 Perilipin family Perilipin PF03036.16 EEA27085.1 - 0.013 14.6 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 0 Perilipin family Perilipin PF03036.16 EEA27086.1 - 0.013 14.6 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 0 Perilipin family PhyH PF05721.13 EEA27087.1 - 9e-20 71.8 0.0 1.5e-19 71.1 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Ribosomal_L27e PF01777.18 EEA27088.1 - 4.7e-39 132.6 3.3 7.2e-39 132.0 3.3 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EEA27088.1 - 0.0036 17.2 0.8 0.01 15.8 0.3 2.0 2 0 0 2 2 2 1 KOW motif Ago_N_1 PF18351.1 EEA27089.1 - 0.01 16.2 0.0 7.1 7.1 0.0 4.0 3 0 0 3 3 3 0 Fungal Argonaute N-terminal domain PI_PP_C PF18365.1 EEA27089.1 - 0.4 10.7 3.5 0.81 9.7 0.1 3.4 4 0 0 4 4 4 0 Phosphoinositide phosphatase C-terminal domain Flu_M1_C PF08289.11 EEA27089.1 - 1.2 9.4 6.6 1.6 9.0 1.0 4.2 4 0 0 4 4 4 0 Influenza Matrix protein (M1) C-terminal domain TRAM_LAG1_CLN8 PF03798.16 EEA27090.1 - 5.6e-55 186.2 14.7 5.6e-55 186.2 14.7 1.9 2 0 0 2 2 2 1 TLC domain MHYT PF03707.16 EEA27090.1 - 0.063 13.5 0.0 0.21 11.8 0.0 1.9 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat SWIB PF02201.18 EEA27091.1 - 2.7e-18 65.6 0.0 5.9e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain RPN6_N PF18055.1 EEA27092.1 - 9.3e-45 151.8 0.4 3.8e-44 149.8 0.4 2.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EEA27092.1 - 1.8e-21 76.6 0.1 7.6e-21 74.6 0.1 2.1 2 1 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 EEA27092.1 - 2.8e-10 39.8 0.2 2.8e-10 39.8 0.2 2.1 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 EEA27092.1 - 3.1e-06 27.4 16.1 0.0023 18.2 1.3 5.2 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA27092.1 - 1.1e-05 25.0 3.7 1.1e-05 25.0 3.7 2.4 2 1 0 2 2 2 1 MalT-like TPR region DDRGK PF09756.9 EEA27092.1 - 1.6e-05 24.6 0.2 3.4e-05 23.5 0.2 1.5 1 0 0 1 1 1 1 DDRGK domain DprA_WH PF17782.1 EEA27092.1 - 0.0074 16.4 0.1 0.32 11.1 0.0 3.1 3 0 0 3 3 3 1 DprA winged helix domain HTH_Crp_2 PF13545.6 EEA27092.1 - 0.04 13.9 0.1 0.66 10.0 0.0 2.9 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain Prefoldin_2 PF01920.20 EEA27092.1 - 0.082 12.9 0.9 0.62 10.0 0.4 2.7 2 0 0 2 2 2 0 Prefoldin subunit INT_SG_DDX_CT_C PF15300.6 EEA27092.1 - 0.083 12.7 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus TPR_2 PF07719.17 EEA27092.1 - 1.5 9.2 11.4 39 4.7 0.6 5.7 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA27092.1 - 4.3 7.3 12.5 1.8 8.5 0.1 5.0 6 1 1 7 7 7 0 Tetratricopeptide repeat Sof1 PF04158.14 EEA27093.1 - 2.7e-28 98.1 11.9 5.2e-28 97.1 11.9 1.5 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 EEA27093.1 - 5.1e-27 93.6 2.4 8e-05 23.3 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA27093.1 - 6.7e-09 35.9 0.1 0.012 15.9 0.0 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA27093.1 - 4.1e-05 22.7 0.1 0.017 14.1 0.0 3.2 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EEA27093.1 - 0.00054 19.9 1.4 0.078 12.9 0.1 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EEA27093.1 - 0.29 9.7 7.7 0.54 8.8 3.8 2.5 1 1 1 2 2 2 0 Nucleoporin Nup120/160 adh_short PF00106.25 EEA27094.1 - 9.4e-34 116.6 0.0 1.3e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA27094.1 - 2e-25 89.8 0.0 3.2e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA27094.1 - 1.3e-07 31.7 0.1 2.7e-07 30.7 0.1 1.4 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EEA27094.1 - 0.00034 20.1 0.0 0.00057 19.4 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) PHD PF00628.29 EEA27095.1 - 2.7e-11 43.2 10.2 4.6e-11 42.4 10.2 1.4 1 0 0 1 1 1 1 PHD-finger FYVE_2 PF02318.16 EEA27095.1 - 0.25 11.6 3.1 0.44 10.8 3.1 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger PHD_2 PF13831.6 EEA27095.1 - 0.28 10.8 10.6 0.11 12.1 6.2 2.5 2 1 0 2 2 2 0 PHD-finger C1_1 PF00130.22 EEA27095.1 - 0.32 10.9 8.1 0.056 13.3 3.6 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RRPl_C4 PF17026.5 EEA27095.1 - 0.83 9.8 4.6 1.9 8.6 4.6 1.6 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Prok-RING_1 PF14446.6 EEA27095.1 - 1.1 9.2 9.1 0.72 9.8 6.8 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD_4 PF16866.5 EEA27095.1 - 1.1 9.3 7.1 2.8 8.1 7.1 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_7 PF02591.15 EEA27095.1 - 1.5 9.1 5.7 19 5.5 0.4 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain CoA_transf_3 PF02515.17 EEA27096.1 - 5e-127 424.0 0.0 5.7e-127 423.8 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Lum_binding PF00677.17 EEA27097.1 - 3.9e-44 148.5 1.0 1.9e-22 79.0 0.2 2.3 2 0 0 2 2 2 2 Lumazine binding domain Nanovirus_coat PF04660.12 EEA27097.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Nanovirus coat protein Brix PF04427.18 EEA27098.1 - 6.2e-52 176.5 0.3 8.4e-52 176.1 0.3 1.2 1 0 0 1 1 1 1 Brix domain DEAD PF00270.29 EEA27099.1 - 2.7e-46 157.6 0.0 4.4e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA27099.1 - 5.5e-29 100.8 0.6 1.5e-28 99.3 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA27099.1 - 1.5e-06 28.4 0.0 3.9e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PGM_PMM_I PF02878.16 EEA27100.1 - 2.5e-16 59.6 0.4 4.5e-07 29.6 0.0 3.1 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EEA27100.1 - 1.7e-12 47.3 2.0 4.8e-12 45.9 1.0 2.4 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 EEA27100.1 - 0.00086 19.5 0.7 0.0056 16.9 0.7 2.2 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EEA27100.1 - 0.0092 16.6 0.6 0.065 13.9 0.2 2.6 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Methyltransf_25 PF13649.6 EEA27101.1 - 7.1e-13 49.1 0.0 1.4e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA27101.1 - 4.3e-11 42.7 0.0 7.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EEA27101.1 - 2.9e-10 40.1 0.0 4.4e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA27101.1 - 2.6e-09 37.6 0.0 5.7e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA27101.1 - 2.8e-06 27.3 0.0 5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EEA27101.1 - 4e-06 26.0 0.1 5.8e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EEA27101.1 - 1.4e-05 24.5 0.0 2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EEA27101.1 - 2.4e-05 24.3 0.5 0.00017 21.6 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA27101.1 - 0.00026 21.7 0.0 0.00048 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA27101.1 - 0.00055 19.5 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EEA27101.1 - 0.0017 17.7 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EEA27101.1 - 0.0031 17.6 0.0 0.0056 16.8 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PRMT5 PF05185.16 EEA27101.1 - 0.0046 16.8 0.0 0.0098 15.8 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_32 PF13679.6 EEA27101.1 - 0.013 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 EEA27101.1 - 0.017 14.9 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 EEA27101.1 - 0.051 13.3 0.1 0.083 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 EEA27101.1 - 0.052 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB Cons_hypoth95 PF03602.15 EEA27101.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Per1 PF04080.13 EEA27102.1 - 1.6e-103 345.9 16.4 2e-103 345.6 16.4 1.1 1 0 0 1 1 1 1 Per1-like family Syndecan PF01034.20 EEA27102.1 - 0.097 12.6 0.7 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Syndecan domain COX7a PF02238.15 EEA27102.1 - 0.99 9.9 4.6 4.1 7.9 0.1 3.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII Per1 PF04080.13 EEA27103.1 - 1.6e-103 345.9 16.4 2e-103 345.6 16.4 1.1 1 0 0 1 1 1 1 Per1-like family Syndecan PF01034.20 EEA27103.1 - 0.097 12.6 0.7 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Syndecan domain COX7a PF02238.15 EEA27103.1 - 0.99 9.9 4.6 4.1 7.9 0.1 3.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII MaoC_dehydratas PF01575.19 EEA27104.1 - 1.8e-21 75.9 0.0 3.7e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EEA27104.1 - 8e-05 22.8 0.0 0.29 11.3 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Acetyltransf_3 PF13302.7 EEA27105.1 - 2.8e-14 54.0 0.0 7.7e-14 52.5 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA27105.1 - 4e-08 33.5 0.0 7.4e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA27105.1 - 0.0037 17.6 0.0 0.0084 16.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TauD PF02668.16 EEA27106.1 - 3.4e-36 125.4 0.4 4.4e-36 125.1 0.4 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EEA27106.1 - 0.011 14.9 0.0 0.2 10.7 0.0 2.1 2 0 0 2 2 2 0 CsiD DUF2442 PF10387.9 EEA27106.1 - 0.09 13.1 0.0 0.33 11.3 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) AAA PF00004.29 EEA27108.1 - 7.6e-41 139.6 0.2 2.2e-40 138.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EEA27108.1 - 6.6e-19 67.6 0.3 1.4e-18 66.6 0.3 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EEA27108.1 - 9.8e-10 38.1 0.0 2.1e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EEA27108.1 - 2.4e-05 24.3 0.0 0.00012 22.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA27108.1 - 0.00016 22.1 1.5 0.019 15.4 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EEA27108.1 - 0.00026 20.8 0.0 0.00061 19.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EEA27108.1 - 0.0011 19.2 1.2 0.0097 16.0 0.0 2.9 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA27108.1 - 0.0022 18.3 2.0 0.1 12.9 0.0 2.9 2 1 1 3 3 3 1 AAA domain PhoH PF02562.16 EEA27108.1 - 0.0041 16.6 0.2 0.06 12.8 0.1 2.3 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 EEA27108.1 - 0.0082 15.5 0.1 0.023 14.1 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EEA27108.1 - 0.01 16.0 0.1 0.038 14.1 0.0 2.1 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 EEA27108.1 - 0.019 14.2 0.0 0.047 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EEA27108.1 - 0.064 13.0 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 EEA27108.1 - 0.2 11.4 6.1 0.28 10.9 0.0 2.8 2 1 1 3 3 3 0 AAA domain AAA_24 PF13479.6 EEA27108.1 - 0.37 10.5 0.1 0.37 10.5 0.1 2.5 3 1 0 3 3 2 0 AAA domain CLZ PF16526.5 EEA27108.1 - 0.69 10.3 10.9 0.15 12.4 6.3 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Atg14 PF10186.9 EEA27108.1 - 1.1 8.3 3.1 2.1 7.3 3.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BLOC1_2 PF10046.9 EEA27108.1 - 2.4 8.5 5.9 1.3 9.4 0.9 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RRN3 PF05327.11 EEA27108.1 - 2.8 6.4 9.9 3.9 5.9 9.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LRR_8 PF13855.6 EEA27109.1 - 0.41 10.5 4.2 0.41 10.4 1.2 2.5 2 0 0 2 2 2 0 Leucine rich repeat Pkinase PF00069.25 EEA27110.1 - 2.1e-69 233.8 0.0 3e-69 233.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27110.1 - 2.5e-31 108.9 0.0 3.5e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EEA27110.1 - 7.9e-14 52.1 0.6 5.1e-13 49.5 0.6 2.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EEA27110.1 - 5e-09 35.9 0.1 2.3e-08 33.7 0.0 1.9 1 1 1 2 2 2 1 Kinase-like C2 PF00168.30 EEA27110.1 - 5.8e-09 36.2 0.0 6.3e-07 29.6 0.0 2.6 2 0 0 2 2 2 1 C2 domain Haspin_kinase PF12330.8 EEA27110.1 - 0.00029 19.9 0.1 0.00029 19.9 0.1 1.7 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EEA27110.1 - 0.0053 16.7 0.0 0.0088 16.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EEA27110.1 - 0.02 14.5 0.3 1.7 8.2 0.1 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EEA27110.1 - 0.058 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Adeno_E3_15_3 PF03307.14 EEA27110.1 - 0.064 13.2 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region Kdo PF06293.14 EEA27110.1 - 0.092 12.1 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EEA27111.1 - 1.4e-69 234.4 0.0 1.8e-69 234.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27111.1 - 1.6e-31 109.5 0.0 2.1e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EEA27111.1 - 3.7e-13 49.9 0.6 3.7e-13 49.9 0.6 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 EEA27111.1 - 2.7e-09 36.8 0.1 1.6e-08 34.3 0.0 1.9 1 1 1 2 2 2 1 Kinase-like C2 PF00168.30 EEA27111.1 - 3.1e-09 37.0 0.0 4.5e-07 30.1 0.0 2.6 2 0 0 2 2 2 1 C2 domain Haspin_kinase PF12330.8 EEA27111.1 - 9.5e-05 21.5 0.2 0.00019 20.5 0.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EEA27111.1 - 0.0036 17.3 0.0 0.006 16.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EEA27111.1 - 0.011 15.3 0.3 1.2 8.7 0.1 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Adeno_E3_15_3 PF03307.14 EEA27111.1 - 0.047 13.6 0.1 0.083 12.8 0.1 1.3 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region Choline_kinase PF01633.20 EEA27111.1 - 0.05 13.2 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EEA27111.1 - 0.064 12.6 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CRC_subunit PF08624.10 EEA27112.1 - 1.4e-50 171.2 0.1 2.1e-50 170.7 0.1 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Cyclin PF08613.11 EEA27113.1 - 2.4e-11 44.2 0.0 3.7e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EEA27113.1 - 3.3e-05 23.6 0.0 5.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2380 PF09533.10 EEA27113.1 - 0.02 14.5 0.2 0.043 13.4 0.2 1.5 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) Cyclin PF08613.11 EEA27114.1 - 2.1e-11 44.4 0.0 3.1e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EEA27114.1 - 3e-05 23.8 0.0 4.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2380 PF09533.10 EEA27114.1 - 0.019 14.6 0.2 0.04 13.5 0.2 1.5 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) His_Phos_1 PF00300.22 EEA27115.1 - 4.5e-28 98.3 0.0 1.2e-27 96.9 0.0 1.7 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 EEA27115.1 - 0.0093 15.3 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) P5-ATPase PF12409.8 EEA27115.1 - 0.081 13.0 0.6 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 P5-type ATPase cation transporter Dor1 PF04124.12 EEA27116.1 - 1.6e-50 171.8 5.6 1.2e-41 142.5 3.2 2.9 2 1 0 2 2 2 2 Dor1-like family Vps51 PF08700.11 EEA27116.1 - 0.0028 17.7 1.2 0.0028 17.7 1.2 2.0 2 0 0 2 2 2 1 Vps51/Vps67 EAF PF09816.9 EEA27117.1 - 8.7e-20 71.0 0.9 1.3e-19 70.4 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor Big_3_2 PF12245.8 EEA27117.1 - 0.0054 17.0 0.2 0.011 16.0 0.2 1.5 1 0 0 1 1 1 1 Bacterial Ig-like domain DUF4576 PF15144.6 EEA27117.1 - 5.9 6.8 6.5 1.1 9.1 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) Cyclin_N PF00134.23 EEA27118.1 - 1.4e-14 53.9 0.1 2.8e-14 52.9 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA27118.1 - 0.009 16.1 0.0 0.09 12.9 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EEA27118.1 - 0.01 15.9 0.3 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Methyltransf_23 PF13489.6 EEA27120.1 - 3.3e-38 131.1 0.0 4.6e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA27120.1 - 2.6e-07 31.3 0.0 1.2e-06 29.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA27120.1 - 2.8e-06 28.0 0.0 5e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA27120.1 - 3.6e-05 24.3 0.0 0.00017 22.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA27120.1 - 0.00034 20.5 0.0 0.00061 19.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA27120.1 - 0.076 12.3 0.0 0.19 11.0 0.0 1.8 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family DAO PF01266.24 EEA27121.1 - 3.3e-43 148.6 0.0 4e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA27121.1 - 1.7e-07 30.8 0.0 0.0046 16.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA27121.1 - 6e-06 25.6 0.1 0.0061 15.7 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EEA27121.1 - 8.7e-05 22.7 0.0 0.00022 21.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA27121.1 - 0.00024 20.3 0.1 0.0053 15.8 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein GMC_oxred_N PF00732.19 EEA27121.1 - 0.0015 18.0 0.1 0.15 11.4 0.0 2.2 2 0 0 2 2 2 1 GMC oxidoreductase Pyr_redox PF00070.27 EEA27121.1 - 0.0036 17.8 0.0 0.01 16.4 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA27121.1 - 0.004 17.1 0.1 0.21 11.6 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EEA27121.1 - 0.007 15.6 0.1 0.04 13.1 0.0 2.0 2 0 0 2 2 2 1 Thi4 family TrkA_N PF02254.18 EEA27121.1 - 0.03 14.6 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Trp_halogenase PF04820.14 EEA27121.1 - 0.041 12.7 0.0 0.073 11.9 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase K_oxygenase PF13434.6 EEA27121.1 - 0.09 11.9 0.0 4.4 6.4 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EEA27121.1 - 0.14 11.4 0.0 1.6 7.9 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain TBP PF00352.21 EEA27122.1 - 1.2e-67 223.8 0.1 9.2e-33 112.1 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EEA27122.1 - 5.9e-05 23.1 0.0 0.22 11.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EEA27122.1 - 0.13 12.1 0.1 0.68 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) TBP PF00352.21 EEA27123.1 - 1.2e-67 223.8 0.1 9.2e-33 112.1 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EEA27123.1 - 5.9e-05 23.1 0.0 0.22 11.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EEA27123.1 - 0.13 12.1 0.1 0.68 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) TBP PF00352.21 EEA27124.1 - 1.2e-67 223.8 0.1 9.2e-33 112.1 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EEA27124.1 - 5.9e-05 23.1 0.0 0.22 11.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EEA27124.1 - 0.13 12.1 0.1 0.68 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) ETF_QO PF05187.13 EEA27125.1 - 2.8e-47 159.2 0.2 4.6e-47 158.5 0.2 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 EEA27125.1 - 2.1e-09 37.4 0.0 7.4e-05 22.5 0.0 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA27125.1 - 5.4e-07 29.7 0.0 1.7e-06 28.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA27125.1 - 3.4e-06 26.4 0.2 0.013 14.7 0.4 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EEA27125.1 - 8.3e-05 22.0 0.0 0.00027 20.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA27125.1 - 0.00022 20.5 0.0 0.0088 15.3 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EEA27125.1 - 0.00071 20.1 0.0 0.63 10.6 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA27125.1 - 0.00083 18.2 0.3 0.0014 17.4 0.3 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EEA27125.1 - 0.0013 18.0 0.1 0.0025 17.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EEA27125.1 - 0.0018 18.3 0.1 0.005 16.9 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EEA27125.1 - 0.0023 16.9 0.0 0.18 10.6 0.2 2.2 1 1 1 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 EEA27125.1 - 0.0042 16.4 0.7 0.012 14.9 0.3 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA27125.1 - 0.007 15.8 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fer4_7 PF12838.7 EEA27125.1 - 0.061 13.9 0.2 0.24 12.0 0.4 1.9 2 0 0 2 2 1 0 4Fe-4S dicluster domain Lycopene_cycl PF05834.12 EEA27125.1 - 0.061 12.4 0.2 0.091 11.8 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Fer4_2 PF12797.7 EEA27125.1 - 0.14 12.3 0.7 0.39 10.9 0.7 1.8 1 0 0 1 1 1 0 4Fe-4S binding domain RRM_1 PF00076.22 EEA27126.1 - 2.1e-15 56.3 0.0 4.4e-11 42.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AA_permease_2 PF13520.6 EEA27127.1 - 5.1e-43 147.5 49.6 6.4e-43 147.1 49.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EEA27127.1 - 1.8e-25 89.5 41.4 2.9e-25 88.8 41.4 1.2 1 0 0 1 1 1 1 Amino acid permease DUF962 PF06127.11 EEA27127.1 - 0.47 10.6 4.0 3.2 7.9 3.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Arginase PF00491.21 EEA27128.1 - 2.1e-90 303.1 0.0 2.6e-90 302.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EEA27128.1 - 0.055 13.7 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain MatE PF01554.18 EEA27129.1 - 7.9e-58 194.7 18.1 7.5e-29 100.5 5.1 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EEA27129.1 - 1.2e-05 25.4 9.2 1.2e-05 25.4 9.2 4.0 3 1 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain CD225 PF04505.12 EEA27129.1 - 9.6 6.4 7.3 0.51 10.5 0.3 2.6 3 0 0 3 3 3 0 Interferon-induced transmembrane protein FolB PF02152.18 EEA27130.1 - 3.2e-11 43.8 0.1 3e-06 27.7 0.0 2.6 3 0 0 3 3 3 2 Dihydroneopterin aldolase Pkinase PF00069.25 EEA27131.1 - 8.4e-67 225.3 0.0 1.1e-66 225.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27131.1 - 1.6e-29 103.0 0.0 2.3e-29 102.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA27131.1 - 0.019 13.9 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EEA27131.1 - 0.044 13.1 0.1 0.16 11.2 0.1 1.9 1 1 1 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 EEA27131.1 - 0.1 11.4 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EEA27131.1 - 0.12 12.0 0.1 4.5 6.8 0.0 2.6 1 1 2 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 PPR PF01535.20 EEA27132.1 - 0.023 14.9 0.1 2.9 8.3 0.0 3.2 3 0 0 3 3 3 0 PPR repeat Utp11 PF03998.13 EEA27132.1 - 0.093 12.7 0.6 0.16 11.9 0.0 1.6 2 0 0 2 2 2 0 Utp11 protein Ndc80_HEC PF03801.13 EEA27133.1 - 1e-61 207.0 0.1 2.6e-61 205.7 0.1 1.7 1 0 0 1 1 1 1 HEC/Ndc80p family TPR_MLP1_2 PF07926.12 EEA27133.1 - 0.12 12.4 46.9 0.024 14.7 11.5 4.2 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein WD40_alt PF14077.6 EEA27133.1 - 0.17 11.8 2.1 0.84 9.6 0.1 2.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif PLAC9 PF15205.6 EEA27133.1 - 0.45 10.9 2.3 20 5.7 0.2 3.2 2 0 0 2 2 2 0 Placenta-specific protein 9 Filament PF00038.21 EEA27133.1 - 0.94 9.0 50.0 0.27 10.8 22.3 3.0 3 1 0 3 3 3 0 Intermediate filament protein CEP63 PF17045.5 EEA27133.1 - 1.3 8.8 40.7 0.17 11.8 1.4 3.7 2 1 1 4 4 4 0 Centrosomal protein of 63 kDa Exonuc_VII_L PF02601.15 EEA27133.1 - 2.5 7.6 24.1 0.79 9.2 7.9 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit Golgin_A5 PF09787.9 EEA27133.1 - 5 6.5 49.5 3.7 6.9 18.6 3.4 2 1 1 3 3 3 0 Golgin subfamily A member 5 Pex14_N PF04695.13 EEA27134.1 - 1.6e-40 139.3 0.0 1.6e-40 139.3 0.0 2.8 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Golgin_A5 PF09787.9 EEA27134.1 - 0.0037 16.8 1.6 0.0058 16.1 1.6 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Baculo_PEP_C PF04513.12 EEA27134.1 - 0.019 15.0 1.7 3.1 7.8 0.5 2.0 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1043 PF06295.12 EEA27134.1 - 0.029 14.4 1.6 0.033 14.2 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF3584 PF12128.8 EEA27134.1 - 0.091 10.3 6.8 0.12 9.8 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TRADD_N PF09034.10 EEA27134.1 - 0.3 11.2 1.1 0.53 10.4 1.1 1.3 1 0 0 1 1 1 0 TRADD, N-terminal domain DUF4407 PF14362.6 EEA27134.1 - 0.38 10.1 3.2 0.73 9.1 3.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EEA27134.1 - 1.1 9.3 3.6 2.4 8.2 3.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.9 EEA27134.1 - 1.1 9.5 9.2 0.07 13.4 2.9 2.1 2 1 0 2 2 2 0 Zinc finger-containing protein Atg14 PF10186.9 EEA27134.1 - 1.3 8.0 4.8 2.2 7.3 4.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ABC_tran PF00005.27 EEA27136.1 - 1.4e-32 113.0 0.0 3.9e-32 111.6 0.0 1.8 2 0 0 2 2 1 1 ABC transporter ABC_membrane PF00664.23 EEA27136.1 - 3.1e-22 79.5 6.7 3.1e-22 79.5 6.7 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EEA27136.1 - 1.5e-05 24.6 0.0 0.00071 19.1 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA27136.1 - 0.001 19.5 0.1 0.002 18.5 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EEA27136.1 - 0.0017 17.6 0.0 0.0029 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DUF87 PF01935.17 EEA27136.1 - 0.0035 17.5 0.1 0.0073 16.4 0.1 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_22 PF13401.6 EEA27136.1 - 0.0068 16.7 0.0 0.018 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EEA27136.1 - 0.011 15.4 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EEA27136.1 - 0.025 14.3 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EEA27136.1 - 0.032 13.4 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit RsgA_GTPase PF03193.16 EEA27136.1 - 0.081 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase DEAD PF00270.29 EEA27136.1 - 0.13 12.1 0.0 0.32 10.7 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase VirE1 PF12189.8 EEA27136.1 - 0.18 12.0 0.1 0.68 10.1 0.1 1.9 1 0 0 1 1 1 0 Single-strand DNA-binding protein SbcCD_C PF13558.6 EEA27136.1 - 0.89 9.8 2.7 2.8 8.2 0.3 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TTL PF03133.15 EEA27137.1 - 3e-56 190.7 0.0 7.1e-56 189.5 0.0 1.6 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family SurE PF01975.17 EEA27137.1 - 4e-50 170.3 0.0 5.8e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 EEA27137.1 - 0.001 18.4 0.0 0.0042 16.4 0.0 2.0 2 0 0 2 2 2 1 YheC/D like ATP-grasp Glyco_trans_4_4 PF13579.6 EEA27137.1 - 0.12 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Seipin PF06775.14 EEA27138.1 - 1.8e-63 214.2 0.4 2.3e-63 213.9 0.4 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Bax1-I PF01027.20 EEA27138.1 - 0.0014 18.5 0.4 0.021 14.7 0.0 2.2 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 DUF4834 PF16118.5 EEA27138.1 - 0.09 13.8 0.1 0.29 12.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Not1 PF04054.15 EEA27139.1 - 1.8e-141 471.3 0.5 4e-141 470.2 0.1 1.8 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EEA27139.1 - 6.5e-97 323.3 2.5 1.5e-96 322.1 2.5 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EEA27139.1 - 5e-52 175.7 3.8 1.1e-51 174.7 3.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EEA27139.1 - 1.7e-41 141.5 0.0 8.3e-41 139.2 0.0 2.2 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EEA27139.1 - 2e-28 99.4 1.8 2.8e-28 98.9 0.1 2.3 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat FCH PF00611.23 EEA27140.1 - 4.3e-16 59.0 0.3 1.7e-15 57.1 0.0 2.2 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EEA27140.1 - 1.7e-13 50.0 0.0 3.7e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EEA27140.1 - 1.6e-11 43.7 0.0 6.5e-11 41.8 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EEA27140.1 - 2.2e-10 40.3 0.1 5.1e-10 39.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Rapsyn_N PF10579.9 EEA27140.1 - 0.11 12.7 0.2 0.26 11.4 0.2 1.7 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region Retinal PF15449.6 EEA27141.1 - 1 7.1 5.9 1.2 6.8 5.9 1.0 1 0 0 1 1 1 0 Retinal protein DUF2457 PF10446.9 EEA27141.1 - 1.3 8.0 5.1 1.7 7.7 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DASH_Duo1 PF08651.10 EEA27142.1 - 3.9e-31 106.6 1.8 3.9e-31 106.6 1.8 1.8 2 0 0 2 2 2 1 DASH complex subunit Duo1 Taxilin PF09728.9 EEA27142.1 - 0.026 13.7 8.5 0.036 13.2 8.5 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein DUF745 PF05335.13 EEA27142.1 - 0.079 12.7 12.0 0.15 11.7 12.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) RCDG1 PF15725.5 EEA27143.1 - 0.86 10.1 8.6 0.84 10.1 0.1 3.2 3 0 0 3 3 3 0 Renal cancer differentiation gene 1 protein p450 PF00067.22 EEA27145.1 - 4.4e-48 164.2 0.0 4.2e-45 154.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 DUF772 PF05598.11 EEA27145.1 - 0.01 15.8 0.0 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 Transposase domain (DUF772) AMP-binding PF00501.28 EEA27146.1 - 4.9e-130 433.9 0.0 1.6e-65 221.4 0.0 2.5 3 0 0 3 3 3 2 AMP-binding enzyme Condensation PF00668.20 EEA27146.1 - 4e-51 174.1 0.1 1.1e-50 172.7 0.0 1.8 2 0 0 2 2 2 1 Condensation domain PP-binding PF00550.25 EEA27146.1 - 7.8e-25 87.0 3.4 1.6e-11 44.4 0.2 3.3 3 0 0 3 3 3 2 Phosphopantetheine attachment site RTA1 PF04479.13 EEA27147.1 - 1.3e-67 227.4 11.2 1.3e-67 227.4 11.2 1.9 1 1 1 2 2 2 1 RTA1 like protein Zn_clus PF00172.18 EEA27148.1 - 2.2e-08 34.1 10.4 3.7e-08 33.4 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA27148.1 - 0.00014 20.8 2.1 0.00021 20.3 0.7 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain RTA1 PF04479.13 EEA27149.1 - 1.9e-72 243.2 17.1 1.9e-72 243.2 17.1 1.3 2 0 0 2 2 2 1 RTA1 like protein HpcH_HpaI PF03328.14 EEA27150.1 - 6.4e-33 113.7 0.0 8.7e-33 113.3 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family zf-primase PF09329.11 EEA27151.1 - 4.2e-17 61.7 1.6 7.7e-17 60.8 1.6 1.5 1 0 0 1 1 1 1 Primase zinc finger DUF4410 PF14366.6 EEA27151.1 - 0.014 15.3 0.2 0.042 13.8 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4410) RNase_H2-Ydr279 PF09468.10 EEA27152.1 - 3.7e-43 147.5 0.2 7.6e-43 146.5 0.2 1.6 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EEA27152.1 - 1.6e-21 76.3 3.3 6.4e-21 74.4 0.1 2.8 3 0 0 3 3 3 1 Ydr279p protein triple barrel domain GalKase_gal_bdg PF10509.9 EEA27153.1 - 1.1e-21 76.2 0.0 1.8e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EEA27153.1 - 4.1e-16 59.0 1.9 9.4e-16 57.8 1.9 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EEA27153.1 - 2.9e-13 50.0 0.0 1.1e-12 48.2 0.0 1.9 2 0 0 2 2 2 1 GHMP kinases C terminal HTH_3 PF01381.22 EEA27153.1 - 0.0067 16.5 0.0 5.7 7.1 0.0 2.6 2 0 0 2 2 2 2 Helix-turn-helix TPP_enzyme_N PF02776.18 EEA27154.1 - 9.6e-56 188.1 0.0 1.7e-54 184.0 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EEA27154.1 - 1.3e-50 171.1 0.0 1.6e-49 167.6 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA27154.1 - 6.6e-38 129.5 0.1 1.4e-37 128.5 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain FANCL_C PF11793.8 EEA27155.1 - 7.2e-06 26.1 3.0 1.5e-05 25.1 3.0 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.7 EEA27155.1 - 5.7e-05 23.2 7.5 0.00011 22.3 7.5 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EEA27155.1 - 0.12 12.7 6.4 0.23 11.8 6.4 1.5 1 0 0 1 1 1 0 Ring finger domain MRP-L28 PF09812.9 EEA27156.1 - 6.1e-07 29.7 0.2 7e-07 29.5 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Ras PF00071.22 EEA27157.1 - 1.7e-48 164.3 0.0 2e-48 164.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA27157.1 - 6.3e-22 78.1 0.0 8.9e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA27157.1 - 9.1e-07 28.5 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA27157.1 - 0.012 15.0 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EEA27157.1 - 0.019 14.4 0.0 0.027 13.9 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EEA27157.1 - 0.071 12.9 0.0 2.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EEA27157.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 EEA27157.1 - 0.22 11.3 0.0 0.38 10.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system NST1 PF13945.6 EEA27158.1 - 4.8e-68 229.1 5.0 4.8e-68 229.1 5.0 5.4 3 2 2 5 5 5 1 Salt tolerance down-regulator Vps35 PF03635.17 EEA27159.1 - 0 1028.3 3.3 0 1028.1 3.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Spore_coat_CotO PF14153.6 EEA27159.1 - 0.27 11.1 7.3 0.57 10.1 7.3 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Glyco_hydro_47 PF01532.20 EEA27164.1 - 1e-173 578.5 0.0 1.1e-173 578.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 EEA27164.1 - 0.15 11.5 2.2 9.9 5.6 0.0 2.8 2 1 0 2 2 2 0 Glycosyl hydrolase family 76 DUF1749 PF08538.10 EEA27165.1 - 1.2e-99 333.2 0.0 1.5e-99 332.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EEA27165.1 - 0.0011 18.2 0.0 0.012 14.9 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EEA27165.1 - 0.01 14.8 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme LIDHydrolase PF10230.9 EEA27165.1 - 0.015 14.8 0.1 0.22 11.0 0.0 2.2 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Chlorophyllase PF07224.11 EEA27165.1 - 0.022 13.8 0.0 0.033 13.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase PGAP1 PF07819.13 EEA27165.1 - 0.099 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Glycos_transf_2 PF00535.26 EEA27166.1 - 8.6e-34 116.8 0.0 1e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EEA27166.1 - 1.3e-13 51.3 0.0 1.7e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EEA27166.1 - 1.7e-05 24.4 0.0 2.3e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EEA27166.1 - 0.0028 17.1 0.0 0.0047 16.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 EEA27166.1 - 0.0094 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 TPR_19 PF14559.6 EEA27167.1 - 1.3e-06 28.8 0.5 0.018 15.5 0.0 3.3 3 1 0 3 3 3 2 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 EEA27168.1 - 0.086 12.8 0.2 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family HlyIII PF03006.20 EEA27169.1 - 4.5e-64 216.2 12.1 5.4e-64 216.0 12.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related Peptidase_U4 PF03419.13 EEA27169.1 - 0.0027 17.0 3.0 0.0051 16.1 3.0 1.4 1 0 0 1 1 1 1 Sporulation factor SpoIIGA HlyIII PF03006.20 EEA27170.1 - 6.3e-64 215.7 12.1 9e-64 215.2 12.1 1.2 1 0 0 1 1 1 1 Haemolysin-III related Peptidase_U4 PF03419.13 EEA27170.1 - 0.0044 16.3 3.1 0.0082 15.5 3.1 1.4 1 0 0 1 1 1 1 Sporulation factor SpoIIGA Zn_clus PF00172.18 EEA27171.1 - 4.3e-07 29.9 9.1 4.3e-07 29.9 9.1 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA27172.1 - 1.1e-25 90.2 2.3 1.8e-25 89.5 2.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CCDC92 PF14916.6 EEA27172.1 - 0.00088 19.0 1.2 0.002 17.9 1.2 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function Filament PF00038.21 EEA27172.1 - 0.0095 15.6 0.5 0.015 14.9 0.5 1.2 1 0 0 1 1 1 1 Intermediate filament protein CCDC-167 PF15188.6 EEA27172.1 - 0.032 14.6 0.3 0.065 13.6 0.3 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF4094 PF13334.6 EEA27172.1 - 0.044 14.2 0.4 0.044 14.2 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) PRKG1_interact PF15898.5 EEA27172.1 - 0.052 14.5 0.5 0.14 13.1 0.5 1.7 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain HR1 PF02185.16 EEA27172.1 - 0.14 12.3 2.1 0.34 11.0 2.1 1.6 1 0 0 1 1 1 0 Hr1 repeat Csm1_N PF18504.1 EEA27172.1 - 0.26 11.7 1.6 0.59 10.5 1.6 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain bZIP_1 PF00170.21 EEA27172.1 - 1 9.5 5.1 2.7 8.1 5.1 1.7 1 0 0 1 1 1 0 bZIP transcription factor Myc-LZ PF02344.15 EEA27172.1 - 5.8 7.1 7.7 14 5.9 7.7 1.6 1 0 0 1 1 1 0 Myc leucine zipper domain ADH_N PF08240.12 EEA27173.1 - 3.2e-22 78.5 0.8 7.1e-22 77.4 0.5 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA27173.1 - 3.2e-14 53.0 0.0 6.1e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EEA27173.1 - 1.9e-05 24.0 0.3 3.2e-05 23.3 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EEA27173.1 - 0.00013 21.4 0.7 0.00018 20.9 0.1 1.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EEA27173.1 - 0.029 15.4 0.0 0.067 14.3 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase NADH_4Fe-4S PF10589.9 EEA27173.1 - 0.22 11.6 1.5 0.47 10.5 1.5 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region adh_short_C2 PF13561.6 EEA27175.1 - 2.5e-47 161.4 4.9 1.2e-39 136.3 4.5 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA27175.1 - 2.4e-45 154.4 3.0 3e-45 154.1 3.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA27175.1 - 2.1e-13 50.6 0.3 2.9e-13 50.1 0.3 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EEA27175.1 - 0.0017 18.2 0.7 0.0029 17.5 0.7 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EEA27175.1 - 0.0073 15.5 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EEA27175.1 - 0.021 14.9 0.1 0.04 14.0 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EEA27175.1 - 0.051 12.9 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EEA27175.1 - 0.063 12.9 0.4 0.1 12.2 0.4 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pkinase PF00069.25 EEA27176.1 - 6.9e-50 169.8 0.0 9.2e-50 169.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27176.1 - 1.9e-30 106.0 0.0 2.4e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA27176.1 - 0.0006 19.8 0.0 0.0016 18.4 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA27176.1 - 0.021 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA27176.1 - 0.084 12.2 0.0 0.23 10.7 0.0 1.8 1 1 1 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 EEA27176.1 - 0.2 10.6 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Acyl-CoA_dh_M PF02770.19 EEA27177.1 - 0.00039 20.6 0.0 0.0011 19.1 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain HTH_26 PF13443.6 EEA27177.1 - 0.14 12.6 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain Pkinase PF00069.25 EEA27178.1 - 8.2e-54 182.7 0.0 1.2e-53 182.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27178.1 - 2.1e-24 86.2 0.0 7.4e-24 84.4 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EEA27178.1 - 0.039 12.9 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 EEA27178.1 - 1.6 8.3 0.0 1.6 8.3 0.0 2.5 3 0 0 3 3 3 0 RIO1 family TMA7 PF09072.10 EEA27179.1 - 3.3e-26 91.9 22.4 3.7e-26 91.7 22.4 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 DHR10 PF18595.1 EEA27180.1 - 0.00017 21.6 1.5 0.00017 21.6 1.5 1.6 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain Cyt-b5 PF00173.28 EEA27181.1 - 2.1e-14 53.4 0.0 2.8e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4519 PF15012.6 EEA27181.1 - 0.087 13.0 0.6 0.16 12.2 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) LigB PF02900.18 EEA27181.1 - 0.23 10.5 0.0 0.29 10.2 0.0 1.1 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase Ish1 PF10281.9 EEA27183.1 - 2e-85 280.8 21.2 9.2e-14 51.5 0.1 7.5 7 0 0 7 7 7 7 Putative stress-responsive nuclear envelope protein HeH PF12949.7 EEA27183.1 - 5.7e-09 35.5 0.3 0.52 10.1 0.0 5.4 5 0 0 5 5 5 3 HeH/LEM domain Slx4 PF09494.10 EEA27183.1 - 6.8e-06 25.9 0.1 30 4.6 0.0 5.7 6 0 0 6 6 6 0 Slx4 endonuclease SAP PF02037.27 EEA27183.1 - 2.8e-05 23.8 0.0 29 4.6 0.0 6.2 6 0 0 6 6 6 0 SAP domain Caudo_TAP PF02413.17 EEA27183.1 - 0.015 15.4 5.4 2.7 8.1 0.3 3.2 2 1 1 3 3 3 0 Caudovirales tail fibre assembly protein, lambda gpK DUF4224 PF13986.6 EEA27183.1 - 0.064 13.2 0.0 19 5.2 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4224) SAM_2 PF07647.17 EEA27183.1 - 8.5 6.6 8.1 88 3.3 0.2 4.7 6 0 0 6 6 6 0 SAM domain (Sterile alpha motif) PQ-loop PF04193.14 EEA27184.1 - 2.6e-22 78.4 19.3 2.8e-12 46.2 2.6 3.6 3 1 1 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 EEA27184.1 - 0.006 17.4 1.1 0.014 16.2 1.0 1.8 1 1 0 1 1 1 1 ER lumen protein retaining receptor SOG2 PF10428.9 EEA27185.1 - 0.62 9.2 4.9 0.64 9.1 4.9 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein TUSC2 PF15000.6 EEA27185.1 - 0.76 10.1 5.4 0.17 12.2 2.0 1.6 2 0 0 2 2 2 0 Tumour suppressor candidate 2 Codanin-1_C PF15296.6 EEA27185.1 - 2 8.5 4.7 6.1 6.9 4.7 1.8 1 1 0 1 1 1 0 Codanin-1 C-terminus Presenilin PF01080.17 EEA27185.1 - 8.4 5.0 5.9 9.2 4.9 5.9 1.1 1 0 0 1 1 1 0 Presenilin Abhydrolase_6 PF12697.7 EEA27187.1 - 4e-09 37.4 0.3 7.1e-09 36.6 0.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA27187.1 - 1.4e-06 27.8 1.5 2e-06 27.3 0.1 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EEA27187.1 - 0.00042 19.8 0.0 0.00074 19.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Amidase PF01425.21 EEA27189.1 - 1.9e-83 280.9 0.2 2.4e-83 280.6 0.2 1.1 1 0 0 1 1 1 1 Amidase Isochorismatase PF00857.20 EEA27189.1 - 1.4e-36 126.3 0.0 2.8e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 Isochorismatase family Fungal_trans PF04082.18 EEA27190.1 - 7.3e-24 84.2 0.3 1.4e-23 83.3 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27190.1 - 6.6e-05 22.9 7.0 0.00011 22.2 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DIOX_N PF14226.6 EEA27191.1 - 1e-24 87.5 0.0 1.8e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA27191.1 - 1.9e-20 73.2 0.0 4.7e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Transp_cyt_pur PF02133.15 EEA27192.1 - 1.1e-95 321.0 31.3 1.5e-95 320.6 31.3 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin RNase_T PF00929.24 EEA27194.1 - 6.3e-09 36.6 0.0 1.5e-07 32.1 0.0 2.5 3 0 0 3 3 3 1 Exonuclease CMD PF02627.20 EEA27194.1 - 0.026 14.6 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family MAGI_u5 PF16666.5 EEA27194.1 - 0.052 13.7 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Unstructured region on MAGI Peptidase_M20 PF01546.28 EEA27195.1 - 1.5e-10 41.1 0.0 2.1e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA27195.1 - 1.6e-07 31.2 0.0 3.7e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain NAD_binding_4 PF07993.12 EEA27196.1 - 7.3e-71 238.4 0.0 1.1e-70 237.8 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EEA27196.1 - 2.6e-70 237.2 0.0 1.6e-69 234.6 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme PP-binding PF00550.25 EEA27196.1 - 8.6e-11 42.0 0.0 1.9e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EEA27196.1 - 8.5e-08 31.5 0.0 1.6e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EEA27196.1 - 2.8e-07 30.2 0.0 6.7e-07 29.0 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EEA27196.1 - 2.2e-06 28.5 0.0 1.9e-05 25.5 0.0 2.7 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain KR PF08659.10 EEA27196.1 - 0.019 14.9 0.1 0.058 13.3 0.0 1.9 2 1 0 2 2 2 0 KR domain NAD_binding_10 PF13460.6 EEA27196.1 - 0.044 13.7 0.1 0.53 10.2 0.3 2.8 2 1 0 2 2 2 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EEA27196.1 - 0.067 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EEA27196.1 - 0.2 10.8 0.0 0.42 9.7 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein zf-rbx1 PF12678.7 EEA27198.1 - 2.4e-06 27.7 4.4 2.9e-06 27.5 2.2 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EEA27198.1 - 7.2e-06 26.2 7.1 3.7e-05 24.0 3.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EEA27198.1 - 1.5e-05 25.0 1.0 3.5e-05 23.8 0.3 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 EEA27198.1 - 0.00067 19.5 2.9 0.0018 18.2 2.9 1.7 1 0 0 1 1 1 1 PHD-finger RINGv PF12906.7 EEA27198.1 - 0.016 15.3 4.0 0.016 15.3 4.0 2.0 2 0 0 2 2 2 0 RING-variant domain FANCL_C PF11793.8 EEA27198.1 - 0.021 15.0 5.5 0.054 13.7 3.2 2.4 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_5 PF14634.6 EEA27198.1 - 0.033 14.1 4.6 0.2 11.7 1.4 2.3 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_4 PF14570.6 EEA27198.1 - 0.49 10.2 3.0 0.33 10.8 0.9 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.6 EEA27198.1 - 0.71 9.8 6.9 0.15 12.0 0.3 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 1 zf-C3HC4 PF00097.25 EEA27198.1 - 1 9.3 8.6 0.33 10.8 4.4 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA27198.1 - 2.7 7.9 4.5 2.2 8.2 1.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CTU2 PF10288.9 EEA27198.1 - 3.6 7.9 6.7 0.97 9.7 0.6 2.9 2 1 1 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-RING-like PF08746.11 EEA27198.1 - 3.8 7.9 6.8 1.5 9.2 3.5 2.0 2 0 0 2 2 2 0 RING-like domain zf-C3HC4_2 PF13923.6 EEA27198.1 - 6.4 6.7 7.6 6 6.8 3.1 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA27198.1 - 9.5 6.3 6.7 2.4 8.3 1.8 2.4 2 0 0 2 2 2 0 RING-type zinc-finger CorA PF01544.18 EEA27200.1 - 0.0023 17.3 11.2 0.0077 15.6 11.2 1.9 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Methyltransf_24 PF13578.6 EEA27201.1 - 1.9e-09 38.5 0.0 3.2e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 EEA27201.1 - 7.5e-08 31.8 0.0 1.1e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Glyco_hydr_30_2 PF14587.6 EEA27202.1 - 3.4e-16 59.8 3.9 4.2e-14 52.9 0.2 2.9 1 1 1 2 2 2 2 O-Glycosyl hydrolase family 30 Glyco_hydro_30C PF17189.4 EEA27202.1 - 1.6e-12 47.5 5.6 6.9e-12 45.4 5.6 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 EEA27202.1 - 9.5e-10 38.2 0.3 1.5e-09 37.5 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30 PF02055.16 EEA27202.1 - 5e-09 35.6 0.2 1.8e-08 33.8 0.2 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Mannosyl_trans3 PF11051.8 EEA27203.1 - 0.0012 18.2 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Phage_stabilise PF11134.8 EEA27203.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Phage stabilisation protein AMP-binding PF00501.28 EEA27204.1 - 8.9e-64 215.6 0.0 1.1e-63 215.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA27204.1 - 8.9e-13 49.0 0.1 1.9e-12 48.0 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CcmF_C PF16327.5 EEA27205.1 - 0.6 9.3 9.1 0.042 13.1 2.4 1.9 2 0 0 2 2 2 0 Cytochrome c-type biogenesis protein CcmF C-terminal AgrB PF04647.15 EEA27205.1 - 0.81 9.0 9.2 0.07 12.4 3.3 2.1 2 0 0 2 2 2 0 Accessory gene regulator B DUF3671 PF12420.8 EEA27205.1 - 1.8 8.7 7.6 5.9 7.0 0.0 3.0 2 1 2 4 4 4 0 Protein of unknown function Insulin_TMD PF17870.1 EEA27205.1 - 3.5 7.8 5.7 1 9.5 0.3 2.7 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment DUF1056 PF06341.11 EEA27205.1 - 7.9 6.9 9.2 13 6.2 1.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1056) SdpI PF13630.6 EEA27205.1 - 8.3 6.6 12.5 0.51 10.5 0.8 3.0 3 0 0 3 3 3 0 SdpI/YhfL protein family Sugar_tr PF00083.24 EEA27206.1 - 1.6e-124 416.2 19.3 1.9e-124 416.0 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA27206.1 - 1.3e-19 70.3 24.2 1.3e-19 70.3 24.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2530 PF10745.9 EEA27206.1 - 0.63 10.3 9.0 0.072 13.3 2.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) TrbL PF04610.14 EEA27207.1 - 4.5 7.0 10.9 1.6 8.4 5.6 2.2 1 1 2 3 3 3 0 TrbL/VirB6 plasmid conjugal transfer protein ABC2_membrane PF01061.24 EEA27208.1 - 1.4e-43 148.8 18.4 1.4e-43 148.8 18.4 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EEA27208.1 - 1.6e-38 132.3 0.0 7.8e-18 65.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EEA27208.1 - 6.8e-31 106.0 0.6 6.8e-31 106.0 0.6 2.4 2 0 0 2 2 1 1 CDR ABC transporter ABC_trans_N PF14510.6 EEA27208.1 - 1.7e-13 51.0 0.0 5.3e-13 49.4 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EEA27208.1 - 2.2e-08 34.7 0.3 0.00096 19.6 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EEA27208.1 - 8e-06 25.6 0.3 0.00077 19.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA27208.1 - 1.7e-05 25.0 0.5 0.12 12.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EEA27208.1 - 2.1e-05 24.5 0.1 0.0048 16.8 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EEA27208.1 - 5.1e-05 23.8 0.0 0.012 16.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 EEA27208.1 - 0.00053 19.2 18.9 0.00053 19.2 18.9 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_29 PF13555.6 EEA27208.1 - 0.0011 18.7 2.2 0.043 13.6 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA27208.1 - 0.0018 18.6 0.1 1.3 9.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EEA27208.1 - 0.0056 16.6 1.5 1.6 8.7 0.2 3.0 3 0 0 3 3 3 1 NACHT domain AAA_17 PF13207.6 EEA27208.1 - 0.0071 16.8 2.1 0.26 11.7 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_21 PF13304.6 EEA27208.1 - 0.0089 15.9 0.6 1.3 8.7 0.1 3.1 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 EEA27208.1 - 0.011 15.3 0.8 0.086 12.4 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 EEA27208.1 - 0.016 14.6 0.0 1.2 8.5 0.0 3.1 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EEA27208.1 - 0.017 14.9 0.2 0.43 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EEA27208.1 - 0.024 14.7 0.1 12 6.0 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase dNK PF01712.19 EEA27208.1 - 0.057 13.3 0.0 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase Rad17 PF03215.15 EEA27208.1 - 0.098 12.6 0.0 18 5.2 0.0 2.8 2 0 0 2 2 2 0 Rad17 P-loop domain AAA PF00004.29 EEA27208.1 - 0.17 12.3 0.0 8.4 6.8 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2304 PF10066.9 EEA27208.1 - 1.2 9.3 7.0 0.46 10.7 1.5 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Hexapep PF00132.24 EEA27209.1 - 6.7e-07 28.8 13.4 3e-05 23.6 5.2 4.9 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EEA27209.1 - 0.00026 20.7 0.9 0.00026 20.7 0.9 2.5 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EEA27209.1 - 0.03 13.3 0.0 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase Glycos_transf_1 PF00534.20 EEA27210.1 - 3.6e-20 72.2 0.0 6.3e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA27210.1 - 9.8e-12 45.5 0.0 1.9e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EEA27210.1 - 1.3e-05 25.5 0.0 3.4e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Arf PF00025.21 EEA27211.1 - 1.2e-72 243.1 0.1 1.3e-72 242.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA27211.1 - 6.6e-15 55.4 0.1 8.9e-15 55.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EEA27211.1 - 1.5e-12 47.4 0.9 2.6e-08 33.4 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EEA27211.1 - 2.3e-12 46.8 0.0 2.6e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EEA27211.1 - 4.6e-11 42.5 0.0 5.7e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EEA27211.1 - 8.4e-10 38.4 0.0 1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA27211.1 - 3.4e-05 23.9 0.0 0.00026 21.0 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EEA27211.1 - 0.0032 16.8 0.2 0.0062 15.9 0.1 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.27 EEA27211.1 - 0.034 13.7 0.0 0.1 12.1 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Arf PF00025.21 EEA27212.1 - 1.2e-72 243.1 0.1 1.3e-72 242.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA27212.1 - 6.6e-15 55.4 0.1 8.9e-15 55.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EEA27212.1 - 1.5e-12 47.4 0.9 2.6e-08 33.4 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EEA27212.1 - 2.3e-12 46.8 0.0 2.6e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EEA27212.1 - 4.6e-11 42.5 0.0 5.7e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EEA27212.1 - 8.4e-10 38.4 0.0 1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA27212.1 - 3.4e-05 23.9 0.0 0.00026 21.0 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EEA27212.1 - 0.0032 16.8 0.2 0.0062 15.9 0.1 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.27 EEA27212.1 - 0.034 13.7 0.0 0.1 12.1 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Hva1_TUDOR PF11160.8 EEA27213.1 - 1.5e-19 69.9 0.7 2e-19 69.5 0.7 1.1 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain Meth_synt_2 PF01717.18 EEA27214.1 - 4.5e-13 49.2 0.0 5.8e-12 45.5 0.0 2.1 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EEA27214.1 - 0.067 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain Peptidase_S15 PF02129.18 EEA27214.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Malate_synthase PF01274.22 EEA27215.1 - 4.6e-232 770.9 0.0 5.2e-232 770.8 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Gln-synt_C PF00120.24 EEA27216.1 - 9.3e-83 278.1 0.0 1.2e-82 277.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain adh_short_C2 PF13561.6 EEA27217.1 - 1.6e-59 201.3 0.8 1.8e-59 201.2 0.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA27217.1 - 1.1e-40 139.2 0.2 1.4e-40 138.9 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA27217.1 - 8.4e-10 38.9 1.3 1.3e-09 38.3 1.3 1.2 1 0 0 1 1 1 1 KR domain Methyltransf_25 PF13649.6 EEA27217.1 - 0.00045 20.9 0.0 0.00087 19.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 EEA27217.1 - 0.0037 16.5 0.0 0.007 15.5 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 EEA27217.1 - 0.0042 17.0 0.1 0.0076 16.2 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_15 PF09445.10 EEA27217.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase UDPG_MGDP_dh_N PF03721.14 EEA27217.1 - 0.059 12.9 0.1 0.095 12.3 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_12 PF08242.12 EEA27217.1 - 0.082 13.7 0.1 0.18 12.6 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain THF_DHG_CYH_C PF02882.19 EEA27217.1 - 0.095 12.0 0.0 0.25 10.6 0.0 1.8 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 EEA27217.1 - 0.11 11.9 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EEA27217.1 - 0.45 10.3 1.8 5.1 6.9 0.4 2.3 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ATP_transf PF09830.9 EEA27218.1 - 5.8e-13 48.8 0.0 9.1e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 ATP adenylyltransferase MFS_1 PF07690.16 EEA27219.1 - 5.7e-44 150.5 31.5 5.7e-44 150.5 31.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA27219.1 - 4e-11 42.4 15.4 4e-11 42.4 15.4 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter HAD PF12710.7 EEA27220.1 - 2.6e-24 86.7 0.0 4.4e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EEA27220.1 - 0.00035 20.0 0.0 0.0013 18.2 0.0 1.8 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.26 EEA27220.1 - 0.0029 17.9 0.4 0.018 15.3 0.0 2.4 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EEA27220.1 - 0.029 13.9 0.0 0.089 12.3 0.0 1.7 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) DUF953 PF06110.11 EEA27221.1 - 5.2e-17 61.6 0.0 6.2e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 EEA27221.1 - 0.0007 19.4 0.0 0.00097 18.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin PF00085.20 EEA27221.1 - 0.021 14.8 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin NAD_binding_4 PF07993.12 EEA27222.1 - 1.2e-29 103.2 0.0 3.3e-29 101.8 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 EEA27222.1 - 2.6e-23 82.3 0.0 3.6e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EEA27222.1 - 8.4e-09 35.2 0.0 2.1e-08 34.0 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA27222.1 - 0.004 17.5 0.3 0.011 16.1 0.3 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Semialdhyde_dh PF01118.24 EEA27222.1 - 0.0062 17.0 0.0 0.013 16.0 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain ABC_tran PF00005.27 EEA27223.1 - 1.3e-47 161.7 0.1 1.7e-27 96.6 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA27223.1 - 4.2e-41 141.4 15.0 1e-23 84.4 8.1 3.3 4 0 0 4 4 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA27223.1 - 2.6e-09 36.9 3.7 0.016 14.6 0.1 4.1 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA27223.1 - 2.7e-07 30.7 4.1 0.54 10.0 0.4 4.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA27223.1 - 2.6e-06 28.1 2.4 0.0017 18.9 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EEA27223.1 - 7.7e-05 22.4 1.2 0.31 10.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.29 EEA27223.1 - 0.00018 21.9 0.3 5 7.5 0.0 4.1 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA27223.1 - 0.00053 20.4 0.2 0.28 11.5 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EEA27223.1 - 0.002 18.2 0.4 0.55 10.3 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EEA27223.1 - 0.0021 18.3 2.2 2.7 8.3 0.1 3.3 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EEA27223.1 - 0.0025 17.4 0.1 0.47 10.0 0.0 2.8 3 0 0 3 3 2 1 AAA domain T2SSE PF00437.20 EEA27223.1 - 0.0033 16.5 3.2 0.11 11.6 0.2 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein Dynamin_N PF00350.23 EEA27223.1 - 0.0045 17.1 0.3 0.11 12.6 0.0 2.5 2 0 0 2 2 2 1 Dynamin family SbcCD_C PF13558.6 EEA27223.1 - 0.0069 16.6 0.1 5.1 7.4 0.0 2.9 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Adeno_IVa2 PF02456.15 EEA27223.1 - 0.013 14.3 0.2 0.56 8.9 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein RsgA_GTPase PF03193.16 EEA27223.1 - 0.02 14.8 0.3 2 8.3 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase Roc PF08477.13 EEA27223.1 - 0.028 14.6 0.1 3.7 7.8 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 EEA27223.1 - 0.031 14.1 0.5 1.6 8.5 0.0 3.0 3 0 0 3 3 3 0 DEAD/DEAH box helicase ABC_ATPase PF09818.9 EEA27223.1 - 0.032 13.0 0.2 0.52 9.1 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Oleosin PF01277.17 EEA27223.1 - 0.047 13.4 0.4 0.26 11.1 0.4 2.3 1 0 0 1 1 1 0 Oleosin FtsK_SpoIIIE PF01580.18 EEA27223.1 - 0.084 12.2 0.1 13 5.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 EEA27223.1 - 0.089 12.4 4.3 0.29 10.7 0.5 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EEA27223.1 - 0.097 12.4 0.9 1.4 8.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain Viral_helicase1 PF01443.18 EEA27223.1 - 0.1 12.3 0.0 5.6 6.6 0.0 2.6 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 EEA27223.1 - 0.1 13.1 0.2 15 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EEA27223.1 - 0.13 12.2 0.0 0.5 10.2 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF87 PF01935.17 EEA27223.1 - 0.18 11.9 4.2 0.56 10.3 0.1 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain DUF2075 PF09848.9 EEA27223.1 - 0.21 10.8 1.3 3.7 6.7 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 EEA27223.1 - 0.22 11.2 0.8 19 4.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA27223.1 - 0.23 11.2 1.7 9.5 5.9 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein Pox_A32 PF04665.12 EEA27223.1 - 0.68 9.3 2.4 8.3 5.8 0.2 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein NACHT PF05729.12 EEA27223.1 - 0.89 9.5 3.6 6.2 6.7 0.1 3.1 3 0 0 3 3 3 0 NACHT domain MFS_1 PF07690.16 EEA27224.1 - 2.7e-43 148.2 35.7 2.7e-43 148.2 35.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Cuticle_3 PF11018.8 EEA27224.1 - 0.064 13.5 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Pupal cuticle protein C1 Oxysterol_BP PF01237.18 EEA27225.1 - 3e-63 213.9 6.6 1.3e-55 188.8 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein Oxysterol_BP PF01237.18 EEA27226.1 - 3e-63 213.9 6.6 1.3e-55 188.8 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein CUE PF02845.16 EEA27227.1 - 4.5e-09 35.8 0.1 9.2e-09 34.8 0.0 1.6 2 0 0 2 2 2 1 CUE domain AlaDh_PNT_N PF05222.15 EEA27229.1 - 4.3e-31 108.0 0.0 7.6e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EEA27229.1 - 4e-07 29.5 0.7 1.7e-05 24.2 0.7 2.8 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain F_bP_aldolase PF01116.20 EEA27230.1 - 6e-90 301.5 0.0 6.7e-90 301.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II UCH PF00443.29 EEA27231.1 - 2.4e-35 122.3 0.0 1.5e-30 106.5 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA27231.1 - 7e-09 35.7 2.0 1.7e-07 31.2 2.0 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Cytochrome_C7 PF14522.6 EEA27231.1 - 1 9.4 3.1 1.3 9.1 0.3 2.5 3 0 0 3 3 3 0 Cytochrome c7 and related cytochrome c RSN1_7TM PF02714.15 EEA27232.1 - 4.4e-79 265.6 24.5 7.5e-79 264.9 24.5 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EEA27232.1 - 8.1e-43 146.7 0.0 1.2e-42 146.2 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EEA27232.1 - 1.7e-38 131.8 1.7 1.7e-38 131.8 1.7 2.4 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport Peptidase_S10 PF00450.22 EEA27233.1 - 1.6e-93 314.4 0.2 2.2e-93 314.0 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase STE2 PF02116.15 EEA27234.1 - 5.3e-93 311.4 23.2 6.2e-93 311.1 23.2 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR UEV PF05743.13 EEA27235.1 - 2.4e-36 124.2 0.0 4.2e-36 123.4 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EEA27235.1 - 3.3e-21 75.0 0.0 9.1e-21 73.6 0.0 1.8 1 0 0 1 1 1 1 Vps23 core domain DUF720 PF05302.11 EEA27235.1 - 0.057 13.3 6.0 0.13 12.1 6.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF720) Snapin_Pallidin PF14712.6 EEA27235.1 - 0.22 11.9 1.9 0.4 11.1 1.9 1.4 1 0 0 1 1 1 0 Snapin/Pallidin Swi5 PF07061.11 EEA27235.1 - 0.7 10.0 1.8 7.8 6.7 0.4 2.5 2 0 0 2 2 2 0 Swi5 MFS_1 PF07690.16 EEA27236.1 - 2.4e-32 112.3 39.8 2.4e-32 112.3 39.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily BAR PF03114.18 EEA27238.1 - 1.4e-67 227.9 4.9 1.9e-67 227.4 4.9 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EEA27238.1 - 1.8e-14 53.1 0.1 3.5e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EEA27238.1 - 9.3e-13 47.8 0.0 1.5e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EEA27238.1 - 8.4e-09 35.0 0.0 2e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.10 EEA27238.1 - 0.006 16.2 4.0 0.42 10.1 2.5 2.2 2 0 0 2 2 2 2 Vps5 C terminal like CT_C_D PF02682.16 EEA27238.1 - 0.056 13.2 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D TMPIT PF07851.13 EEA27238.1 - 2.4 7.4 6.4 2.9 7.0 0.0 2.2 1 1 1 2 2 2 0 TMPIT-like protein CorA PF01544.18 EEA27238.1 - 3.6 6.8 7.3 20 4.4 0.0 2.7 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein BRE1 PF08647.11 EEA27238.1 - 9.8 6.3 19.7 2.6 8.2 0.2 3.4 3 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase Aminotran_5 PF00266.19 EEA27239.1 - 6.2e-94 315.0 0.0 7.4e-94 314.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA27239.1 - 1.9e-05 24.1 0.0 2.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EEA27239.1 - 0.00083 18.8 0.1 0.0025 17.2 0.1 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EEA27239.1 - 0.0066 15.2 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain IDO PF01231.18 EEA27240.1 - 7.6e-162 539.0 0.0 8.7e-162 538.8 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 EEA27240.1 - 0.0079 15.0 0.0 0.042 12.6 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1864) CsbD PF05532.12 EEA27241.1 - 1.9e-13 50.1 8.9 5.5e-11 42.2 2.1 2.8 3 0 0 3 3 3 2 CsbD-like ADH_zinc_N_2 PF13602.6 EEA27243.1 - 1.3e-24 87.8 0.0 2.1e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EEA27243.1 - 1.5e-16 60.5 0.0 2.4e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 EEA27243.1 - 0.0061 16.3 0.8 0.016 15.0 0.1 2.0 3 0 0 3 3 3 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Epimerase PF01370.21 EEA27243.1 - 0.0099 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EEA27243.1 - 0.07 12.2 0.2 0.13 11.3 0.0 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain zf-C2H2 PF00096.26 EEA27244.1 - 0.037 14.5 3.3 2 9.0 0.0 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type KTI12 PF08433.10 EEA27245.1 - 1.9e-62 211.2 0.0 1.1e-60 205.4 0.0 2.7 1 1 0 1 1 1 1 Chromatin associated protein KTI12 WD40_like PF17005.5 EEA27246.1 - 0.074 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 WD40-like domain TFIIA PF03153.13 EEA27247.1 - 0.038 14.0 31.7 0.039 14.0 31.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit T2SSC PF11356.8 EEA27247.1 - 0.11 12.4 8.1 0.15 12.0 8.1 1.2 1 0 0 1 1 1 0 Type II secretion system protein C DUF2722 PF10846.8 EEA27247.1 - 0.14 11.1 16.1 0.17 10.8 16.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 EEA27247.1 - 0.37 10.4 30.9 0.59 9.7 30.9 1.3 1 0 0 1 1 1 0 Spt20 family Neur_chan_memb PF02932.16 EEA27247.1 - 1.3 9.0 4.5 1.3 9.0 4.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 EEA27247.1 - 1.5 7.5 8.0 1.5 7.4 8.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GET2 PF08690.10 EEA27247.1 - 1.5 8.5 12.0 1.5 8.4 12.0 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Dicty_REP PF05086.12 EEA27247.1 - 2.2 6.2 8.8 2.3 6.1 8.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 EEA27247.1 - 2.6 6.7 8.5 2.5 6.8 8.5 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 EEA27247.1 - 8 4.5 8.9 7.3 4.6 8.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Methyltransf_16 PF10294.9 EEA27248.1 - 3.8e-17 62.6 0.0 5e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EEA27248.1 - 2e-05 24.5 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA27248.1 - 0.019 15.7 0.0 0.041 14.6 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EEA27248.1 - 0.094 12.1 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Peptidase_C14 PF00656.22 EEA27249.1 - 3.5e-59 200.8 0.0 4.3e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Nitroreductase PF00881.24 EEA27250.1 - 5.8e-10 39.5 0.0 7.6e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family F-box PF00646.33 EEA27251.1 - 2.2e-05 24.2 0.1 5.2e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EEA27251.1 - 0.00041 20.2 0.1 0.0012 18.7 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EEA27251.1 - 0.015 15.2 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 F-box DUF2236 PF09995.9 EEA27254.1 - 2.1e-44 152.4 0.5 2.8e-44 152.0 0.5 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) SUIM_assoc PF16619.5 EEA27254.1 - 1.1 9.4 7.7 2.5 8.3 7.7 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CcmD PF04995.14 EEA27254.1 - 7.4 6.7 7.4 8.4 6.6 3.8 2.7 2 1 0 2 2 2 0 Heme exporter protein D (CcmD) DUF3712 PF12505.8 EEA27255.1 - 4.9e-29 101.1 2.0 4.9e-29 101.1 2.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) Fungal_trans PF04082.18 EEA27256.1 - 7.4e-12 44.9 0.1 1.9e-11 43.5 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27256.1 - 1.5e-06 28.2 12.8 3.3e-06 27.1 12.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ion_trans_2 PF07885.16 EEA27257.1 - 1.4e-26 92.3 25.4 1.1e-14 54.2 7.3 2.9 3 0 0 3 3 3 2 Ion channel DUF5453 PF17534.2 EEA27257.1 - 0.11 12.4 6.0 0.043 13.8 1.9 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5453) Ion_trans PF00520.31 EEA27257.1 - 0.23 10.7 21.8 0.15 11.3 2.0 3.3 2 1 1 3 3 3 0 Ion transport protein Palm_thioest PF02089.15 EEA27258.1 - 2.1e-82 276.6 0.0 2.5e-82 276.4 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 EEA27258.1 - 0.0017 17.8 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 EEA27258.1 - 0.063 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EEA27258.1 - 0.066 13.0 0.2 6.9 6.4 0.1 2.3 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase MFS_1 PF07690.16 EEA27259.1 - 9.3e-44 149.8 44.7 9.3e-44 149.8 44.7 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA27259.1 - 4e-06 26.0 15.4 4e-06 26.0 15.4 3.1 2 2 0 2 2 2 2 Sugar (and other) transporter Fungal_trans PF04082.18 EEA27260.1 - 8e-14 51.3 0.1 1.3e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27260.1 - 4.3e-09 36.4 9.2 7.5e-09 35.6 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EEA27261.1 - 8.7e-05 22.3 0.1 0.0002 21.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA27261.1 - 0.0016 18.3 0.1 0.0036 17.1 0.1 1.6 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 EEA27261.1 - 0.065 13.6 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 PRANC domain DUF1722 PF08349.11 EEA27261.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) CENP-L PF13092.6 EEA27262.1 - 8.7e-42 143.1 0.2 1.5e-41 142.4 0.2 1.4 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 Sulfate_transp PF00916.20 EEA27263.1 - 5.2e-79 265.7 14.4 7.2e-79 265.3 14.4 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EEA27263.1 - 7.1e-18 64.4 0.0 1.2e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EEA27263.1 - 0.00012 22.4 0.0 0.0003 21.1 0.0 1.8 1 1 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EEA27263.1 - 0.0007 20.0 4.4 0.0007 20.0 4.4 3.0 3 0 0 3 3 3 1 Molybdate transporter of MFS superfamily DUF1656 PF07869.12 EEA27263.1 - 6.4 6.9 10.4 16 5.6 0.4 4.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1656) EIF_2_alpha PF07541.12 EEA27264.1 - 2e-37 127.8 0.0 3.8e-37 126.9 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EEA27264.1 - 1.1e-13 51.3 0.7 2.3e-13 50.3 0.7 1.6 1 0 0 1 1 1 1 S1 RNA binding domain PKD_channel PF08016.12 EEA27265.1 - 6.6e-08 31.6 19.8 1.7e-07 30.3 19.1 2.0 1 1 0 1 1 1 1 Polycystin cation channel FYVE PF01363.21 EEA27266.1 - 1.4e-19 69.9 32.1 2.6e-15 56.3 10.6 2.7 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 EEA27266.1 - 1.9e-17 62.7 1.8 4.2e-17 61.6 1.0 2.1 2 0 0 2 2 2 1 Rabenosyn Rab binding domain zf-AN1 PF01428.16 EEA27266.1 - 0.0027 17.8 6.8 0.0027 17.8 6.8 3.8 3 1 1 4 4 4 1 AN1-like Zinc finger YqaH PF17448.2 EEA27266.1 - 0.027 14.8 0.2 0.096 13.0 0.2 1.9 1 0 0 1 1 1 0 Uncharacterized YqaH-like Val_tRNA-synt_C PF10458.9 EEA27266.1 - 0.038 14.3 0.3 14 6.0 0.0 2.9 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm TMF_TATA_bd PF12325.8 EEA27266.1 - 0.1 12.9 3.1 0.17 12.1 0.3 2.7 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding UBZ_FAAP20 PF15750.5 EEA27266.1 - 0.47 10.4 3.3 5.7 7.0 0.9 2.8 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zf-WRNIP1_ubi PF18279.1 EEA27266.1 - 3.1 8.7 6.1 57 4.7 2.7 3.0 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-TFIIB PF13453.6 EEA27266.1 - 6.1 6.3 8.8 15 5.0 2.2 3.7 3 0 0 3 3 3 0 Transcription factor zinc-finger DUF2428 PF10350.9 EEA27267.1 - 0.014 14.6 0.1 0.024 13.9 0.1 1.3 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) Fungal_trans_2 PF11951.8 EEA27267.1 - 0.03 13.2 0.2 0.042 12.7 0.2 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Methyltransf_2 PF00891.18 EEA27268.1 - 6.4e-17 61.5 0.0 1.1e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation PF08100.11 EEA27268.1 - 0.038 14.0 0.0 0.08 13.0 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain Acyltransferase PF01553.21 EEA27269.1 - 6.3e-10 38.8 0.0 6.2e-09 35.6 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase DUF3910 PF13049.6 EEA27270.1 - 0.051 13.9 0.6 3.7 7.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3910) FAM180 PF15173.6 EEA27270.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 FAM180 family DUF4078 PF13300.6 EEA27271.1 - 2e-26 92.1 11.0 2e-26 92.1 11.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4078) Homoserine_dh PF00742.19 EEA27272.1 - 1.3e-52 178.2 0.0 1.7e-52 177.8 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EEA27272.1 - 5.1e-14 52.9 0.0 1.1e-13 51.8 0.0 1.6 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DEC-1_N PF04625.13 EEA27272.1 - 0.27 10.2 2.1 6.1 5.7 0.9 2.1 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region DUF3445 PF11927.8 EEA27273.1 - 1.1e-77 260.7 0.1 1.3e-77 260.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Aldo_ket_red PF00248.21 EEA27274.1 - 1.5e-12 47.3 0.0 2.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Kdo PF06293.14 EEA27275.1 - 1.8e-10 40.6 0.0 1e-09 38.0 0.0 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA27275.1 - 4.2e-07 30.1 0.3 0.021 14.8 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 EEA27275.1 - 6.8e-07 28.9 0.0 8e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.20 EEA27275.1 - 0.00048 19.8 0.0 0.00067 19.3 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EEA27275.1 - 0.0014 18.2 0.0 0.54 9.8 0.0 2.6 3 0 0 3 3 3 2 RIO1 family Pkinase_Tyr PF07714.17 EEA27275.1 - 0.058 12.7 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DHDPS PF00701.22 EEA27276.1 - 7.8e-42 143.0 0.0 9.7e-42 142.6 0.0 1.2 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family TPR_19 PF14559.6 EEA27276.1 - 0.34 11.4 2.7 0.22 12.1 0.6 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Phage_holin_2_3 PF16080.5 EEA27277.1 - 1.6 8.5 7.5 0.42 10.4 0.4 3.0 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Methyltransf_2 PF00891.18 EEA27278.1 - 1.3e-21 76.9 0.0 2.1e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EEA27278.1 - 0.0013 18.7 0.0 0.0038 17.2 0.0 1.7 1 0 0 1 1 1 1 Dimerisation domain Rrf2 PF02082.20 EEA27278.1 - 0.019 15.3 0.0 0.17 12.3 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulator Dimerisation PF08100.11 EEA27278.1 - 0.022 14.8 0.1 0.23 11.5 0.0 2.9 2 1 0 2 2 2 0 Dimerisation domain AP4E_app_platf PF14807.6 EEA27278.1 - 0.089 13.2 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Umbravirus_LDM PF04817.12 EEA27278.1 - 0.14 11.5 0.1 0.22 10.9 0.1 1.2 1 0 0 1 1 1 0 Umbravirus long distance movement (LDM) family CSTF2_hinge PF14327.6 EEA27278.1 - 0.51 10.8 3.0 1.6 9.2 0.2 2.8 3 0 0 3 3 3 0 Hinge domain of cleavage stimulation factor subunit 2 Peptidase_A4 PF01828.17 EEA27279.1 - 2.3e-61 206.9 15.8 3.1e-61 206.5 15.8 1.2 1 0 0 1 1 1 1 Peptidase A4 family DUF11 PF01345.18 EEA27279.1 - 0.43 10.9 5.6 0.11 12.8 1.8 2.2 2 1 0 2 2 2 0 Domain of unknown function DUF11 Anp1 PF03452.14 EEA27280.1 - 7.7e-107 356.6 0.0 9.1e-107 356.4 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EEA27280.1 - 0.055 13.3 0.0 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 Mito_carr PF00153.27 EEA27281.1 - 7e-55 182.9 0.0 2.5e-18 65.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Zip PF02535.22 EEA27284.1 - 3e-59 200.9 6.2 6.6e-59 199.8 6.2 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter DUF456 PF04306.13 EEA27284.1 - 8.3 6.7 16.5 43 4.4 7.9 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF456) Nop16 PF09420.10 EEA27285.1 - 6.1e-60 202.9 9.9 7.2e-60 202.6 9.9 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Pex24p PF06398.11 EEA27286.1 - 2e-58 198.1 0.0 2.5e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Pkinase PF00069.25 EEA27287.1 - 1.7e-53 181.7 0.0 2.5e-53 181.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27287.1 - 1.5e-19 70.3 0.0 2.7e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 EEA27287.1 - 0.15 12.3 0.1 0.32 11.2 0.1 1.5 1 0 0 1 1 1 0 ABC1 family APH PF01636.23 EEA27287.1 - 0.18 11.7 0.0 1.1 9.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA27287.1 - 0.2 11.2 0.3 0.42 10.2 0.3 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase COPIIcoated_ERV PF07970.12 EEA27288.1 - 1.7e-37 129.4 0.2 3.1e-37 128.6 0.2 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EEA27288.1 - 2.3e-24 85.5 0.0 4.2e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Cupin_2 PF07883.11 EEA27289.1 - 2.5e-23 81.6 0.6 5.5e-15 54.8 0.1 2.4 2 1 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EEA27289.1 - 8.7e-07 28.5 0.0 0.0083 15.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 EEA27289.1 - 1e-06 28.7 1.0 0.00033 20.6 0.2 2.5 2 1 1 3 3 3 2 AraC-like ligand binding domain CENP-C_C PF11699.8 EEA27289.1 - 8e-05 22.8 0.0 0.0015 18.7 0.0 2.1 2 0 0 2 2 2 1 Mif2/CENP-C like ARD PF03079.14 EEA27289.1 - 0.0073 16.5 0.1 0.02 15.0 0.0 1.7 2 0 0 2 2 2 1 ARD/ARD' family HMMR_N PF15905.5 EEA27290.1 - 0.00017 21.2 40.5 0.00017 21.2 40.5 2.7 2 0 0 2 2 1 1 Hyaluronan mediated motility receptor N-terminal Filament PF00038.21 EEA27290.1 - 0.00031 20.5 32.4 0.00031 20.5 32.4 3.8 3 1 0 3 3 3 1 Intermediate filament protein MscS_porin PF12795.7 EEA27290.1 - 0.0008 19.0 38.8 0.0008 19.0 38.8 4.4 2 2 1 3 3 2 1 Mechanosensitive ion channel porin domain ADIP PF11559.8 EEA27290.1 - 0.02 15.0 8.9 0.02 15.0 8.9 6.4 4 2 2 6 6 5 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.11 EEA27290.1 - 0.42 11.0 46.1 0.41 11.1 1.1 7.0 5 1 2 7 7 7 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 EEA27290.1 - 0.55 10.6 34.9 0.25 11.7 9.7 4.2 2 1 2 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 KASH_CCD PF14662.6 EEA27290.1 - 0.61 9.9 60.2 3.7 7.3 29.0 4.1 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Trypan_PARP PF05887.11 EEA27290.1 - 0.63 10.0 25.3 2 8.4 25.3 1.8 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) APG17 PF04108.12 EEA27290.1 - 0.99 8.4 36.1 0.021 14.0 18.3 2.9 1 1 2 3 3 3 0 Autophagy protein Apg17 DUF4988 PF16378.5 EEA27290.1 - 1.7 8.3 10.4 8.1 6.1 1.1 3.8 3 0 0 3 3 3 0 Domain of unknown function NPV_P10 PF05531.12 EEA27290.1 - 2.5 8.6 22.0 14 6.2 2.6 4.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EEA27290.1 - 4.3 7.4 30.0 0.29 11.2 1.5 3.9 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Redoxin PF08534.10 EEA27291.1 - 5e-37 126.9 0.0 5.7e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EEA27291.1 - 6.5e-12 45.4 0.0 8.2e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Ycf9 PF01737.17 EEA27291.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 YCF9 Fungal_trans PF04082.18 EEA27292.1 - 4.1e-25 88.3 1.1 7.7e-25 87.4 0.2 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27292.1 - 0.033 14.3 1.5 0.065 13.4 1.5 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3231 PF11553.8 EEA27292.1 - 0.14 11.7 0.1 11 5.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) DUF2014 PF09427.10 EEA27293.1 - 1.3e-97 326.3 0.3 1.9e-97 325.8 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 EEA27293.1 - 3.4e-17 62.1 0.3 9.8e-17 60.7 0.3 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.21 EEA27293.1 - 0.036 14.2 2.2 0.081 13.0 1.5 1.9 2 0 0 2 2 2 0 bZIP transcription factor TSC22 PF01166.18 EEA27293.1 - 0.17 12.2 1.4 0.89 9.9 0.6 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family ZapB PF06005.12 EEA27293.1 - 1.4 9.4 9.0 0.055 13.9 0.9 2.7 3 0 0 3 3 3 0 Cell division protein ZapB Ferric_reduct PF01794.19 EEA27294.1 - 1.6e-19 70.2 11.5 1.6e-19 70.2 11.5 2.3 1 1 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EEA27294.1 - 7.1e-19 68.5 0.2 1.7e-16 60.7 0.2 2.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EEA27294.1 - 1.1e-11 44.7 0.0 2.8e-08 33.8 0.0 2.8 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 EEA27294.1 - 0.0017 19.0 0.0 0.36 11.5 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain FSH1 PF03959.13 EEA27295.1 - 1.8e-31 109.5 0.0 2.9e-31 108.8 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) MAAL_C PF07476.11 EEA27295.1 - 0.063 12.4 0.1 0.17 11.0 0.0 1.6 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus DUF2567 PF10821.8 EEA27296.1 - 1.4e-05 25.2 0.8 2.3e-05 24.5 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2567) RNase_PH PF01138.21 EEA27298.1 - 7.1e-05 23.3 0.0 0.00015 22.3 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 NAD_kinase PF01513.21 EEA27299.1 - 5.8e-81 271.9 0.0 8.2e-81 271.4 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase GAF_2 PF13185.6 EEA27300.1 - 2.4e-13 50.5 0.0 4.4e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EEA27300.1 - 9.9e-09 35.9 0.0 1.3e-08 35.6 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EEA27300.1 - 0.0022 18.4 0.0 0.0036 17.7 0.0 1.4 1 0 0 1 1 1 1 GAF domain bZIP_2 PF07716.15 EEA27301.1 - 2.2e-06 27.6 6.1 2.2e-06 27.6 6.1 1.7 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 EEA27301.1 - 1e-05 25.5 6.4 1.8e-05 24.7 6.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 EEA27301.1 - 0.061 13.1 0.8 0.061 13.1 0.8 1.9 2 0 0 2 2 2 0 Septum formation initiator Sugar_tr PF00083.24 EEA27302.1 - 7e-110 368.0 17.3 8.6e-110 367.7 17.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA27302.1 - 3.4e-25 88.7 32.8 3.9e-25 88.5 22.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA27302.1 - 0.00013 20.6 0.4 0.00021 19.8 0.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Clat_adaptor_s PF01217.20 EEA27304.1 - 1.8e-52 177.1 1.3 2.1e-52 176.8 1.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Fungal_trans_2 PF11951.8 EEA27304.1 - 0.048 12.5 0.0 0.061 12.1 0.0 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain PulA_N1 PF17999.1 EEA27304.1 - 0.069 13.9 0.2 0.12 13.1 0.2 1.5 1 1 0 1 1 1 0 Pullulanase N1-terminal domain Maf1 PF09174.10 EEA27305.1 - 4.8e-58 196.2 0.0 6.2e-58 195.8 0.0 1.1 1 0 0 1 1 1 1 Maf1 regulator DUF1694 PF07997.11 EEA27305.1 - 0.075 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) CAP59_mtransfer PF11735.8 EEA27306.1 - 4.3e-87 291.8 0.0 6e-87 291.3 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 PCP_red PF08369.10 EEA27306.1 - 0.034 14.4 0.4 0.87 9.9 0.2 2.5 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit UPRTase PF14681.6 EEA27307.1 - 5.5e-53 179.5 0.1 2.6e-47 160.9 0.0 2.0 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EEA27307.1 - 1.6e-05 24.5 0.0 2.2e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Peptidase_M30 PF10460.9 EEA27307.1 - 0.16 10.9 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Peptidase M30 UPRTase PF14681.6 EEA27308.1 - 5.5e-53 179.5 0.1 2.6e-47 160.9 0.0 2.0 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EEA27308.1 - 1.6e-05 24.5 0.0 2.2e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Peptidase_M30 PF10460.9 EEA27308.1 - 0.16 10.9 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Peptidase M30 UPRTase PF14681.6 EEA27309.1 - 5.5e-53 179.5 0.1 2.6e-47 160.9 0.0 2.0 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EEA27309.1 - 1.6e-05 24.5 0.0 2.2e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Peptidase_M30 PF10460.9 EEA27309.1 - 0.16 10.9 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Peptidase M30 GTP_CH_N PF12471.8 EEA27310.1 - 4.4e-89 297.4 0.0 6.2e-89 296.9 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EEA27310.1 - 6.6e-18 64.8 0.0 1.1e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II DEAD PF00270.29 EEA27311.1 - 6.5e-30 104.2 0.1 2.6e-29 102.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA27311.1 - 1.1e-23 83.6 0.1 3.1e-23 82.2 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EEA27311.1 - 0.025 14.3 0.0 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain CMS1 PF14617.6 EEA27311.1 - 0.078 12.3 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit tRNA-synt_1b PF00579.25 EEA27311.1 - 0.12 11.7 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) SH3_9 PF14604.6 EEA27312.1 - 6.4e-26 90.0 0.2 7.4e-15 54.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 EEA27312.1 - 9.1e-24 83.5 1.5 2.2e-23 82.3 0.0 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EEA27312.1 - 7.7e-18 63.8 0.1 2.6e-08 33.3 0.0 2.6 2 0 0 2 2 2 2 SH3 domain C1_1 PF00130.22 EEA27312.1 - 4.8e-15 55.2 5.3 7.6e-15 54.5 5.3 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_10 PF17902.1 EEA27312.1 - 5.5e-05 23.1 0.0 0.27 11.3 0.0 2.8 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EEA27312.1 - 0.0003 20.4 0.1 0.87 9.3 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_2 PF03107.16 EEA27312.1 - 0.01 16.1 4.2 0.019 15.3 4.2 1.4 1 0 0 1 1 1 0 C1 domain GrpE PF01025.19 EEA27312.1 - 0.83 9.3 12.9 1.8 8.2 2.4 2.6 2 0 0 2 2 2 0 GrpE PhaP_Bmeg PF09602.10 EEA27312.1 - 3.2 7.7 14.1 0.15 12.0 1.2 3.4 3 1 0 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF5531 PF17671.1 EEA27312.1 - 5.7 6.8 7.9 0.39 10.6 1.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5531) PBP PF01161.20 EEA27313.1 - 3.4e-09 37.1 0.0 4e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Choline_transpo PF04515.12 EEA27314.1 - 2.6e-82 276.7 25.4 2.6e-82 276.7 25.4 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter Fungal_trans PF04082.18 EEA27315.1 - 3.6e-27 95.1 0.2 9.3e-27 93.7 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_72 PF03198.14 EEA27316.1 - 2.5e-133 444.2 2.1 2.9e-133 444.0 2.1 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EEA27316.1 - 6.1e-06 25.9 0.0 1.8e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF1373 PF07117.11 EEA27316.1 - 0.011 15.8 2.0 0.017 15.1 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1373) MFS_1 PF07690.16 EEA27317.1 - 5.7e-29 101.1 24.9 5.7e-29 101.1 24.9 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily LapA_dom PF06305.11 EEA27317.1 - 0.15 11.9 1.6 1.4 8.8 0.0 3.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain GDPD PF03009.17 EEA27318.1 - 7.5e-30 104.5 0.0 1e-29 104.1 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family LIM PF00412.22 EEA27319.1 - 6.4e-20 71.1 16.3 5.2e-12 45.8 2.8 3.0 3 0 0 3 3 3 2 LIM domain zf_UBZ PF18439.1 EEA27319.1 - 0.15 11.7 0.1 0.15 11.7 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger NAD_binding_5 PF07994.12 EEA27320.1 - 3.2e-144 480.2 0.0 3.8e-144 480.0 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EEA27320.1 - 1.3e-45 154.1 0.5 2.7e-45 153.1 0.5 1.6 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase ADH_N PF08240.12 EEA27321.1 - 7.9e-26 90.1 1.3 2.1e-25 88.7 1.3 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA27321.1 - 1.3e-18 67.2 0.2 2.9e-18 66.1 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EEA27321.1 - 0.0011 18.3 0.5 0.0022 17.3 0.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain LpxI_C PF06230.11 EEA27321.1 - 0.003 17.4 1.1 0.0064 16.3 0.8 1.6 2 0 0 2 2 2 1 LpxI C-terminal domain Sacchrp_dh_NADP PF03435.18 EEA27321.1 - 0.009 16.3 0.1 0.017 15.3 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EEA27321.1 - 0.062 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Imm70 PF15601.6 EEA27321.1 - 0.19 11.3 0.0 0.45 10.1 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 70 zf-Tim10_DDP PF02953.15 EEA27322.1 - 1.5e-20 72.6 2.9 2.2e-20 72.1 2.9 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 EEA27322.1 - 0.0027 17.4 2.2 0.004 16.9 2.2 1.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) RhoGAP PF00620.27 EEA27323.1 - 5.5e-39 133.4 0.0 8.7e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PIG-F PF06699.11 EEA27324.1 - 8.8e-72 241.0 3.3 1e-71 240.8 3.3 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Gly-zipper_Omp PF13488.6 EEA27324.1 - 0.0051 16.8 1.8 1.2 9.2 0.5 2.2 2 0 0 2 2 2 2 Glycine zipper Gly-zipper_YMGG PF13441.6 EEA27324.1 - 0.21 11.3 8.7 3.6 7.4 8.8 2.2 1 1 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 EEA27324.1 - 0.81 9.5 8.2 2.9 7.7 3.5 2.3 2 0 0 2 2 2 0 Glycine-zipper domain NAD_binding_4 PF07993.12 EEA27327.1 - 8.5e-37 126.7 0.0 1.3e-36 126.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EEA27327.1 - 1.8e-22 79.6 0.0 4.9e-22 78.1 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.21 EEA27327.1 - 4.2e-10 39.5 0.0 7.5e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EEA27327.1 - 0.00016 21.7 0.0 0.0004 20.4 0.0 1.6 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EEA27327.1 - 0.00093 18.3 0.0 0.0019 17.3 0.0 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 EEA27327.1 - 0.0024 18.2 0.0 0.0062 16.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 EEA27327.1 - 0.055 12.6 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 EEA27327.1 - 0.057 13.8 0.0 2.5 8.6 0.0 2.5 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain tRNA-synt_1d PF00750.19 EEA27328.1 - 3.9e-100 335.2 7.2 2.8e-98 329.1 7.2 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EEA27328.1 - 7.3e-28 97.1 0.3 1.8e-27 95.8 0.3 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EEA27328.1 - 1.2e-07 32.2 0.3 3.7e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain YabA PF06156.13 EEA27328.1 - 0.17 12.5 0.7 0.39 11.4 0.3 1.8 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 EEA27328.1 - 0.17 11.6 1.7 0.4 10.5 1.7 1.5 1 0 0 1 1 1 0 Septum formation initiator PIP5K PF01504.18 EEA27329.1 - 1.2e-39 136.2 0.0 4.8e-38 131.0 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PIP5K PF01504.18 EEA27330.1 - 6.9e-36 123.9 0.1 2.6e-34 118.7 0.1 2.0 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase FAD_binding_6 PF00970.24 EEA27331.1 - 2.5e-32 111.2 0.0 3.8e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EEA27331.1 - 2e-28 99.2 0.0 3.1e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EEA27331.1 - 1e-05 25.7 0.0 0.00056 20.1 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EEA27331.1 - 0.021 15.0 0.0 0.036 14.3 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain DUF3605 PF12239.8 EEA27332.1 - 5.5e-60 202.1 0.2 6.7e-60 201.9 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) SMC_N PF02463.19 EEA27333.1 - 3.4e-71 239.2 3.4 5.2e-71 238.6 3.4 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA27333.1 - 3.9e-33 114.2 0.2 2e-32 111.9 0.0 2.4 3 0 0 3 3 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EEA27333.1 - 2e-20 73.8 1.4 1.1e-11 45.1 0.1 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA27333.1 - 4.8e-18 66.4 2.3 4.8e-18 66.4 2.3 7.0 1 1 2 3 3 2 1 AAA domain AAA_15 PF13175.6 EEA27333.1 - 2.6e-16 60.3 55.6 9.4e-09 35.4 25.5 4.6 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 EEA27333.1 - 0.0052 16.5 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EEA27333.1 - 0.22 10.8 0.0 0.22 10.8 0.0 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EEA27333.1 - 0.37 11.3 0.0 0.37 11.3 0.0 6.6 3 2 1 4 4 2 0 ABC transporter APG6_N PF17675.1 EEA27333.1 - 0.43 11.1 123.3 1.5 9.4 9.3 9.0 4 2 4 8 8 8 0 Apg6 coiled-coil region DegQ PF08181.11 EEA27333.1 - 0.69 10.0 4.8 17 5.6 0.0 4.2 3 0 0 3 3 3 0 DegQ (SacQ) family DUF87 PF01935.17 EEA27333.1 - 2.8 8.0 0.0 2.8 8.0 0.0 6.7 4 2 1 5 5 4 0 Helicase HerA, central domain RIO1 PF01163.22 EEA27334.1 - 5.5e-72 241.3 0.2 5.5e-72 241.3 0.2 1.8 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 EEA27334.1 - 0.011 15.1 0.0 0.078 12.3 0.0 2.3 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA27334.1 - 0.021 14.7 0.0 0.86 9.5 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA27334.1 - 0.052 13.1 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase Flavin_Reduct PF01613.18 EEA27335.1 - 0.00047 20.2 0.0 0.00052 20.1 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain XFP_N PF09364.10 EEA27336.1 - 2.1e-173 576.3 0.0 2.7e-173 575.9 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 EEA27336.1 - 6.2e-84 280.5 0.0 8.8e-84 280.0 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 EEA27336.1 - 9.6e-81 269.7 0.0 2.1e-80 268.6 0.0 1.6 2 0 0 2 2 2 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase APG17 PF04108.12 EEA27337.1 - 5.3e-132 440.7 0.6 6.3e-132 440.4 0.6 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Trigger_N PF05697.13 EEA27337.1 - 0.048 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) FAP206 PF12018.8 EEA27337.1 - 0.056 13.0 0.0 0.27 10.7 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function DHHW PF14286.6 EEA27337.1 - 0.11 11.8 0.1 0.21 10.9 0.1 1.4 1 0 0 1 1 1 0 DHHW protein Tropomyosin_1 PF12718.7 EEA27337.1 - 4.7 7.4 7.2 0.66 10.1 0.1 3.0 4 0 0 4 4 4 0 Tropomyosin like Hemerythrin PF01814.23 EEA27337.1 - 7.1 7.3 9.6 21 5.7 0.2 4.2 4 1 0 4 4 4 0 Hemerythrin HHE cation binding domain WD40 PF00400.32 EEA27338.1 - 4.9e-48 160.1 24.6 1.2e-06 29.1 0.1 8.5 7 1 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EEA27338.1 - 5.5e-14 51.8 0.2 1.2e-13 50.7 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA27338.1 - 7.1e-11 41.7 0.1 7.1e-11 41.7 0.1 2.9 2 1 1 3 3 3 1 F-box domain Nup160 PF11715.8 EEA27338.1 - 5.2e-10 38.6 4.7 0.11 11.2 0.2 5.6 3 2 3 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EEA27338.1 - 2.2e-07 31.1 0.0 0.0092 16.3 0.0 4.9 2 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EEA27338.1 - 0.01 15.7 0.2 0.068 13.1 0.0 2.5 2 1 0 2 2 2 0 F-box PRANC PF09372.10 EEA27338.1 - 0.18 12.1 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 PRANC domain GFA PF04828.14 EEA27339.1 - 2.6e-13 50.1 0.0 3.9e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme zf-NADH-PPase PF09297.11 EEA27339.1 - 0.027 14.1 0.3 0.027 14.1 0.3 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain ADH_N PF08240.12 EEA27340.1 - 8.1e-26 90.0 5.8 1.3e-25 89.4 5.8 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA27340.1 - 3.2e-13 49.8 0.0 5.1e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA27340.1 - 0.00066 19.1 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EEA27340.1 - 0.0051 17.9 0.0 0.013 16.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 EEA27340.1 - 0.018 14.9 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding ELFV_dehydrog PF00208.21 EEA27340.1 - 0.027 14.2 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AlaDh_PNT_C PF01262.21 EEA27340.1 - 0.26 10.5 1.8 0.67 9.2 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_N PF08240.12 EEA27341.1 - 1e-19 70.4 2.4 1.8e-19 69.6 2.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA27341.1 - 3.4e-13 49.7 0.0 5.4e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA27341.1 - 0.0007 19.0 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EEA27341.1 - 0.0056 17.7 0.0 0.013 16.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 EEA27341.1 - 0.019 14.8 0.0 0.027 14.3 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding ELFV_dehydrog PF00208.21 EEA27341.1 - 0.032 14.0 0.0 0.05 13.3 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AlaDh_PNT_C PF01262.21 EEA27341.1 - 0.23 10.7 1.4 0.71 9.1 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Glycos_transf_2 PF00535.26 EEA27343.1 - 0.024 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 MHYT PF03707.16 EEA27344.1 - 3.1e-21 75.3 17.2 3.5e-08 33.5 0.1 4.5 4 0 0 4 4 4 4 Bacterial signalling protein N terminal repeat ILVD_EDD PF00920.21 EEA27345.1 - 1.9e-209 696.6 0.1 2.3e-209 696.3 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family 5_nucleotid_C PF02872.18 EEA27345.1 - 0.13 12.5 0.0 0.38 11.0 0.0 1.8 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain Pkinase PF00069.25 EEA27346.1 - 3.3e-44 151.2 0.0 5.6e-43 147.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27346.1 - 3.1e-26 92.2 0.0 4.5e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA27346.1 - 0.014 14.2 0.0 0.026 13.3 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Tim17 PF02466.19 EEA27347.1 - 6.6e-28 97.3 4.3 9.9e-28 96.7 4.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2428 PF10350.9 EEA27348.1 - 1.5e-65 221.3 0.0 3.7e-65 219.9 0.0 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EEA27348.1 - 0.0005 20.1 0.9 3.3 8.2 0.1 5.4 5 0 0 5 5 5 1 HEAT repeat DUF4390 PF14334.6 EEA27348.1 - 0.059 12.8 0.6 0.12 11.8 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4390) HEAT_2 PF13646.6 EEA27348.1 - 0.24 11.8 1.4 8 6.9 0.1 4.0 4 0 0 4 4 4 0 HEAT repeats HEAT_EZ PF13513.6 EEA27348.1 - 0.51 10.9 6.0 31 5.2 0.1 5.3 5 0 0 5 5 5 0 HEAT-like repeat PTase_Orf2 PF11468.8 EEA27349.1 - 5.5e-121 403.4 0.0 7.2e-121 403.0 0.0 1.1 1 0 0 1 1 1 1 Aromatic prenyltransferase Orf2 PX PF00787.24 EEA27350.1 - 4.2e-19 68.6 0.0 3.4e-18 65.7 0.0 2.4 2 1 0 2 2 2 1 PX domain Vps5 PF09325.10 EEA27350.1 - 4.8e-07 29.6 10.8 0.0005 19.7 2.9 2.1 2 0 0 2 2 2 2 Vps5 C terminal like Peptidase_C10 PF01640.17 EEA27350.1 - 0.017 15.5 0.0 0.031 14.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase C10 family UCH PF00443.29 EEA27351.1 - 3.4e-67 226.6 0.0 5.9e-67 225.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EEA27351.1 - 5.5e-14 52.6 0.0 2.8e-13 50.3 0.0 2.3 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 EEA27351.1 - 9.4e-07 28.7 0.0 0.012 15.2 0.0 2.7 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase TonB_N PF16031.5 EEA27351.1 - 0.0011 19.4 3.9 0.0034 17.9 3.9 1.8 1 0 0 1 1 1 1 TonB polyproline region USP7_C2 PF14533.6 EEA27351.1 - 0.0039 16.9 0.0 0.069 12.9 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal Con-6 PF10346.9 EEA27357.1 - 2.9e-30 104.0 0.3 6.1e-16 58.2 0.1 2.1 2 0 0 2 2 2 2 Conidiation protein 6 SpoIIIAH PF12685.7 EEA27357.1 - 0.0038 17.1 0.5 0.56 10.0 0.1 2.0 1 1 1 2 2 2 2 SpoIIIAH-like protein Glyco_hydro_16 PF00722.21 EEA27359.1 - 2.5e-08 33.6 0.0 5.6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF3328 PF11807.8 EEA27360.1 - 4.4e-51 173.8 1.0 5.5e-51 173.4 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) SspP PF08179.12 EEA27361.1 - 1.6 9.3 4.0 3.7 8.1 0.6 2.5 2 0 0 2 2 2 0 Small acid-soluble spore protein P family DUF3328 PF11807.8 EEA27362.1 - 6.3e-20 71.9 1.6 4.4e-19 69.1 1.6 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) MAPEG PF01124.18 EEA27363.1 - 1.4e-15 57.4 3.7 1.6e-15 57.2 3.7 1.1 1 0 0 1 1 1 1 MAPEG family DUF3425 PF11905.8 EEA27364.1 - 7.5e-10 38.9 8.5 1.8e-08 34.4 8.5 2.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EEA27364.1 - 0.006 16.7 3.9 0.011 15.8 3.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor Abhydrolase_1 PF00561.20 EEA27365.1 - 1e-21 77.8 0.0 1.2e-21 77.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA27365.1 - 3.3e-13 50.7 0.0 4.2e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA27365.1 - 5.7e-11 42.2 0.0 1.3e-10 41.0 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 EEA27365.1 - 0.034 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Peptidase_S9 PF00326.21 EEA27365.1 - 0.069 12.6 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Acyltransferase PF01553.21 EEA27366.1 - 0.024 14.2 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase Lipase_3 PF01764.25 EEA27367.1 - 2.6e-21 76.0 0.0 4.8e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EEA27367.1 - 0.0012 19.5 0.6 0.0029 18.2 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EEA27367.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein Chlorophyllase2 PF12740.7 EEA27367.1 - 0.097 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF1899 PF08953.11 EEA27368.1 - 2.2e-35 120.3 0.0 4.3e-35 119.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EEA27368.1 - 1.5e-19 69.6 0.3 2.9e-19 68.7 0.3 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EEA27368.1 - 6.3e-17 61.6 6.0 0.00054 20.7 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA27368.1 - 4.7e-05 23.6 0.0 0.76 10.1 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA27368.1 - 0.019 13.6 4.0 0.75 8.4 0.2 2.6 2 1 1 3 3 3 0 Nucleoporin Nup120/160 SlyX PF04102.12 EEA27368.1 - 0.15 12.7 1.3 0.4 11.3 1.3 1.7 1 0 0 1 1 1 0 SlyX DivIC PF04977.15 EEA27368.1 - 0.82 9.5 5.5 0.23 11.2 2.1 1.8 2 0 0 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.8 EEA27368.1 - 6.2 6.9 7.1 3.9 7.5 5.3 1.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Kinesin PF00225.23 EEA27369.1 - 2.4e-103 345.6 0.0 2.4e-103 345.6 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EEA27369.1 - 3.6e-61 205.5 0.0 1e-60 204.0 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding Bac_DnaA PF00308.18 EEA27369.1 - 0.0011 18.9 0.7 0.0044 16.9 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_16 PF13191.6 EEA27369.1 - 0.002 18.5 8.2 0.011 16.1 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 EEA27369.1 - 0.0089 15.8 0.1 0.023 14.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EEA27369.1 - 0.11 12.7 3.4 0.33 11.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain Arm_APC_u3 PF16629.5 EEA27369.1 - 0.49 10.0 6.8 8.4 5.9 2.3 2.4 2 0 0 2 2 2 0 Armadillo-associated region on APC DUF4854 PF16146.5 EEA27369.1 - 3.5 8.0 11.7 7.7 6.9 0.8 4.1 4 1 0 4 4 4 0 Domain of unknown function (DUF4854) LIP PF03583.14 EEA27370.1 - 5.4e-63 213.0 0.0 7.2e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Acetyltransf_7 PF13508.7 EEA27371.1 - 0.0018 18.7 0.0 0.005 17.2 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA27371.1 - 0.12 12.3 0.1 0.61 10.0 0.0 2.1 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain TPR_10 PF13374.6 EEA27372.1 - 3.5e-35 118.9 0.1 1.7e-12 46.7 0.0 4.1 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EEA27372.1 - 9e-30 102.8 0.0 5.6e-15 55.4 0.0 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat NB-ARC PF00931.22 EEA27372.1 - 7.7e-12 44.9 0.0 1.3e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_7 PF13176.6 EEA27372.1 - 8.7e-10 37.9 0.0 0.0015 18.4 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA27372.1 - 9.3e-09 34.8 0.0 0.045 13.9 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 EEA27372.1 - 1.3e-07 31.1 0.7 5.6e-07 29.0 0.7 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 EEA27372.1 - 2.8e-07 31.1 0.0 2.8e-06 27.8 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EEA27372.1 - 3.4e-07 30.3 0.0 6.7e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain TPR_8 PF13181.6 EEA27372.1 - 1.1e-06 28.3 0.0 0.033 14.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA27372.1 - 2.6e-06 27.0 0.0 0.076 12.9 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA27372.1 - 1e-05 25.9 0.0 3.4e-05 24.2 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA27372.1 - 6.8e-05 22.4 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 MalT-like TPR region ANAPC3 PF12895.7 EEA27372.1 - 0.0032 17.6 0.1 4.4 7.6 0.0 3.6 1 1 2 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 AAA_22 PF13401.6 EEA27372.1 - 0.0041 17.4 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EEA27372.1 - 0.011 15.6 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea SRP54 PF00448.22 EEA27372.1 - 0.036 13.7 0.0 0.16 11.6 0.0 2.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain TPR_16 PF13432.6 EEA27372.1 - 0.056 14.1 0.0 20 6.0 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA27372.1 - 0.097 13.4 0.0 9.7 7.1 0.0 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DnaB_C PF03796.15 EEA27372.1 - 0.17 11.2 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain PPR PF01535.20 EEA27372.1 - 0.2 12.0 0.2 57 4.3 0.0 3.4 4 0 0 4 4 3 0 PPR repeat Methyltransf_23 PF13489.6 EEA27373.1 - 2e-20 73.3 0.0 2.7e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA27373.1 - 4.5e-10 39.5 0.0 4e-09 36.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA27373.1 - 3.3e-09 37.3 0.0 8.9e-09 35.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA27373.1 - 2.7e-06 27.9 0.0 5.5e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA27373.1 - 6.8e-05 23.6 0.0 0.00057 20.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA27373.1 - 0.0042 16.7 0.0 0.024 14.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EEA27373.1 - 0.0064 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EEA27373.1 - 0.036 13.4 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EEA27373.1 - 0.06 12.8 0.2 0.38 10.2 0.0 2.3 3 0 0 3 3 3 0 Putative methyltransferase Ubie_methyltran PF01209.18 EEA27373.1 - 0.072 12.4 0.0 0.62 9.4 0.0 2.2 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EEA27373.1 - 0.088 12.1 0.0 0.22 10.8 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase p450 PF00067.22 EEA27374.1 - 1.2e-57 195.7 0.0 1.5e-57 195.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 EEA27375.1 - 8.7e-30 104.0 0.1 1.1e-29 103.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA27375.1 - 5.1e-19 68.5 0.0 8.4e-19 67.8 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA27375.1 - 2.7e-07 30.7 0.0 4.1e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_7 PF13241.6 EEA27375.1 - 0.0042 17.5 0.0 0.015 15.8 0.0 1.8 2 0 0 2 2 2 1 Putative NAD(P)-binding Methyltransf_12 PF08242.12 EEA27375.1 - 0.037 14.8 0.0 0.061 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1098 PF06497.11 EEA27375.1 - 0.1 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1098) Mur_ligase_M PF08245.12 EEA27376.1 - 4.4e-06 26.8 0.0 1.5e-05 25.1 0.0 1.9 2 1 0 2 2 2 1 Mur ligase middle domain Mur_ligase_C PF02875.21 EEA27376.1 - 6.1e-06 26.4 0.0 1.3e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain zf-C3HC4_3 PF13920.6 EEA27377.1 - 0.00068 19.4 12.2 0.0012 18.6 12.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CBFD_NFYB_HMF PF00808.23 EEA27378.1 - 5.5e-15 55.4 2.5 8.9e-15 54.7 2.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA27378.1 - 2.2e-05 24.8 0.2 2.2e-05 24.8 0.2 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 HMG14_17 PF01101.18 EEA27378.1 - 0.19 12.7 0.0 0.19 12.7 0.0 2.8 3 1 0 3 3 3 0 HMG14 and HMG17 SOXp PF12336.8 EEA27378.1 - 0.52 11.4 3.7 1 10.4 3.1 1.9 1 1 0 1 1 1 0 SOX transcription factor CBFD_NFYB_HMF PF00808.23 EEA27379.1 - 5.5e-15 55.4 2.5 8.9e-15 54.7 2.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA27379.1 - 2.2e-05 24.8 0.2 2.2e-05 24.8 0.2 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 HMG14_17 PF01101.18 EEA27379.1 - 0.19 12.7 0.0 0.19 12.7 0.0 2.8 3 1 0 3 3 3 0 HMG14 and HMG17 SOXp PF12336.8 EEA27379.1 - 0.52 11.4 3.7 1 10.4 3.1 1.9 1 1 0 1 1 1 0 SOX transcription factor Amino_oxidase PF01593.24 EEA27380.1 - 6.4e-61 207.0 0.4 9.4e-59 199.9 0.4 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EEA27380.1 - 2e-09 37.5 0.3 4.9e-09 36.3 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA27380.1 - 0.0036 17.8 0.5 0.37 11.4 0.1 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA27380.1 - 0.0091 15.3 0.1 0.057 12.6 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA27380.1 - 0.012 14.9 0.3 0.66 9.2 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA27380.1 - 0.013 14.8 0.1 0.038 13.2 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 EEA27380.1 - 0.056 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EEA27380.1 - 0.12 11.9 0.2 0.47 10.0 0.1 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 EEA27380.1 - 0.21 10.6 0.1 0.36 9.8 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 EEA27380.1 - 0.29 9.8 0.9 0.46 9.1 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein RAI16-like PF10257.9 EEA27381.1 - 4.3e-88 295.6 0.6 6.6e-88 295.0 0.6 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein ADH_N PF08240.12 EEA27382.1 - 8.2e-10 38.5 0.0 2.7e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA27382.1 - 2.7e-08 33.8 0.4 6.8e-08 32.6 0.4 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EEA27382.1 - 0.02 14.8 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase MFS_1 PF07690.16 EEA27383.1 - 2e-13 50.0 47.3 2.4e-11 43.2 19.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA27384.1 - 4.8e-78 263.0 23.7 5.5e-78 262.8 23.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA27384.1 - 3e-19 69.2 53.9 7.8e-17 61.2 32.7 2.7 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_1 PF07690.16 EEA27385.1 - 1.1e-12 47.5 34.2 1.1e-12 47.5 34.2 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EEA27385.1 - 6.7e-10 38.9 3.0 6.7e-10 38.9 3.0 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 AntA PF08346.12 EEA27385.1 - 0.024 15.2 0.0 0.047 14.3 0.0 1.4 1 0 0 1 1 1 0 AntA/AntB antirepressor LapA_dom PF06305.11 EEA27385.1 - 0.51 10.2 2.1 5.6 6.9 0.0 3.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Polysacc_deac_1 PF01522.21 EEA27387.1 - 1e-15 57.7 0.2 9.8e-15 54.5 0.2 2.1 1 1 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 EEA27387.1 - 0.01 15.0 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Fringe PF02434.16 EEA27388.1 - 3.6e-12 46.3 0.0 5.7e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EEA27388.1 - 0.037 13.8 0.0 0.29 10.9 0.0 2.0 1 1 0 1 1 1 0 Galactosyltransferase PAN_4 PF14295.6 EEA27388.1 - 3.1 7.8 5.8 0.89 9.5 2.5 1.8 2 0 0 2 2 2 0 PAN domain MFS_1 PF07690.16 EEA27389.1 - 4.9e-12 45.4 9.0 4.9e-12 45.4 9.0 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily RTA1 PF04479.13 EEA27390.1 - 7.2e-69 231.5 11.2 9.2e-69 231.2 11.2 1.1 1 0 0 1 1 1 1 RTA1 like protein Aldo_ket_red PF00248.21 EEA27391.1 - 3.1e-49 167.8 0.0 3.5e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pro-kuma_activ PF09286.11 EEA27391.1 - 0.077 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Pro-kumamolisin, activation domain Response_reg PF00072.24 EEA27392.1 - 7e-22 77.7 0.4 2e-21 76.2 0.2 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 EEA27392.1 - 1.1e-21 77.5 0.5 5.6e-21 75.1 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EEA27392.1 - 8e-16 57.8 0.6 2.1e-15 56.5 0.1 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EEA27392.1 - 2.7e-13 50.0 0.6 0.00057 20.1 0.1 3.8 3 0 0 3 3 3 3 PAS fold PAS_4 PF08448.10 EEA27392.1 - 6.9e-06 26.3 0.0 8.3e-05 22.8 0.0 3.0 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 EEA27392.1 - 9.6e-06 25.8 0.0 1.4 9.3 0.0 4.5 3 1 0 3 3 3 2 PAS domain PAS PF00989.25 EEA27392.1 - 2e-05 24.5 0.0 0.063 13.3 0.0 2.9 2 0 0 2 2 2 2 PAS fold MotA_ExbB PF01618.16 EEA27392.1 - 0.19 11.5 0.5 0.71 9.6 0.0 2.1 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family HATPase_c PF02518.26 EEA27393.1 - 9.1e-22 77.7 0.5 5.2e-21 75.3 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EEA27393.1 - 7.3e-16 58.0 0.6 1.9e-15 56.6 0.1 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EEA27393.1 - 2.2e-13 50.3 0.6 0.00053 20.2 0.1 3.7 3 0 0 3 3 3 3 PAS fold PAS_4 PF08448.10 EEA27393.1 - 5.7e-06 26.6 0.0 7.7e-05 22.9 0.0 3.1 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 EEA27393.1 - 1e-05 25.7 0.0 1.2 9.4 0.0 4.5 3 1 0 3 3 3 2 PAS domain PAS PF00989.25 EEA27393.1 - 1.8e-05 24.7 0.0 0.059 13.4 0.0 2.9 2 0 0 2 2 2 2 PAS fold MotA_ExbB PF01618.16 EEA27393.1 - 0.17 11.7 0.5 0.66 9.7 0.0 2.1 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family HATPase_c PF02518.26 EEA27394.1 - 2e-31 108.8 0.0 1.4e-30 106.1 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EEA27394.1 - 7.4e-21 74.4 0.0 2.1e-20 73.0 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EEA27394.1 - 3.7e-19 68.5 0.0 1.4e-18 66.7 0.0 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.6 EEA27394.1 - 4.9e-14 53.1 0.2 3.2e-12 47.1 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain GAF_2 PF13185.6 EEA27394.1 - 6.4e-12 46.0 0.0 2e-11 44.3 0.0 1.9 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EEA27394.1 - 3.2e-06 27.8 0.0 9.8e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EEA27394.1 - 0.00011 22.6 0.0 0.00027 21.3 0.0 1.7 1 0 0 1 1 1 1 GAF domain NB-ARC PF00931.22 EEA27394.1 - 0.00035 19.9 0.3 0.045 12.9 0.1 3.2 2 1 0 2 2 2 1 NB-ARC domain Pkinase PF00069.25 EEA27394.1 - 0.00053 19.4 0.0 0.0039 16.6 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain AAA_22 PF13401.6 EEA27394.1 - 0.0035 17.6 0.0 0.28 11.5 0.1 3.4 2 1 0 2 2 2 1 AAA domain MeaB PF03308.16 EEA27394.1 - 0.008 15.2 0.1 0.018 14.0 0.1 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EEA27394.1 - 0.0084 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 NTPase HATPase_c_3 PF13589.6 EEA27394.1 - 0.0092 15.8 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NACHT PF05729.12 EEA27394.1 - 0.038 13.9 0.1 1.7 8.6 0.0 2.9 2 0 0 2 2 2 0 NACHT domain TPR_12 PF13424.6 EEA27394.1 - 0.27 11.5 2.9 12 6.2 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA27394.1 - 4.8 7.9 7.8 7.2 7.4 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat Allantoicase PF03561.15 EEA27395.1 - 6.3e-89 295.4 0.0 2.3e-43 147.6 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat tRNA-synt_2b PF00587.25 EEA27396.1 - 1.2e-17 64.5 0.0 2.3e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EEA27396.1 - 4.1e-10 39.8 6.7 7.5e-10 39.0 6.7 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain GAS PF13851.6 EEA27396.1 - 0.011 15.2 8.7 0.022 14.1 8.7 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding ERM PF00769.19 EEA27396.1 - 0.057 13.2 10.0 0.11 12.3 10.0 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family BCAS2 PF05700.11 EEA27396.1 - 0.092 12.4 5.2 0.17 11.6 4.6 1.6 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Atg14 PF10186.9 EEA27396.1 - 0.15 11.1 3.1 0.26 10.4 3.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-Q PF13094.6 EEA27396.1 - 0.16 12.2 8.2 0.27 11.4 8.2 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Jnk-SapK_ap_N PF09744.9 EEA27396.1 - 0.17 12.1 7.8 0.38 11.0 7.8 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Vps53_N PF04100.12 EEA27396.1 - 0.19 10.7 2.1 0.27 10.2 2.1 1.2 1 0 0 1 1 1 0 Vps53-like, N-terminal DUF724 PF05266.14 EEA27396.1 - 0.23 11.2 3.1 0.38 10.5 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.13 EEA27396.1 - 1.1 8.4 4.5 1.8 7.7 4.1 1.4 2 0 0 2 2 2 0 TMPIT-like protein FapA PF03961.13 EEA27396.1 - 1.7 7.2 7.5 3.3 6.2 7.5 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A ABC_tran_CTD PF16326.5 EEA27396.1 - 3.1 8.1 12.1 1.5 9.1 0.4 3.5 2 1 1 3 3 3 0 ABC transporter C-terminal domain Cytochrom_B561 PF03188.16 EEA27397.1 - 1.2e-13 51.4 3.4 1.2e-13 51.4 3.4 1.8 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF4271 PF14093.6 EEA27397.1 - 0.002 18.1 8.5 0.002 18.1 8.5 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4271) PepSY_TM PF03929.16 EEA27397.1 - 0.22 11.2 5.4 2.2 7.9 3.1 2.6 2 1 0 2 2 2 0 PepSY-associated TM region DUF4079 PF13301.6 EEA27397.1 - 0.32 11.1 13.7 0.76 9.9 6.7 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) Glyco_hydro_88 PF07470.13 EEA27398.1 - 1.2e-92 310.7 6.0 1.3e-92 310.5 6.0 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 EEA27398.1 - 0.0056 15.2 0.2 0.0056 15.2 0.2 1.5 2 0 0 2 2 2 1 Beta-L-arabinofuranosidase, GH127 Bep_C_terminal PF17841.1 EEA27398.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 BID domain of Bartonella effector protein (Bep) MFS_1 PF07690.16 EEA27399.1 - 1.6e-31 109.6 22.3 1.6e-31 109.6 22.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily LapA_dom PF06305.11 EEA27399.1 - 2.5 8.0 7.5 6.9 6.6 0.1 3.6 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain DUF2768 PF10966.8 EEA27399.1 - 2.6 8.5 9.5 12 6.4 3.4 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) BTB PF00651.31 EEA27400.1 - 0.0051 17.0 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Fungal_trans_2 PF11951.8 EEA27401.1 - 7.8e-27 94.1 0.3 1.1e-26 93.6 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27401.1 - 9.7e-07 28.8 6.9 9.7e-07 28.8 6.9 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 EEA27402.1 - 4.8e-67 226.1 0.0 6.6e-67 225.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27402.1 - 1.8e-31 109.3 0.0 4.9e-30 104.7 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA27402.1 - 0.00028 20.3 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EEA27402.1 - 0.0044 16.7 0.0 0.022 14.4 0.0 2.0 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EEA27402.1 - 0.0046 16.3 0.0 0.012 14.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EEA27402.1 - 0.013 15.4 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA27402.1 - 0.018 14.0 0.1 0.041 12.8 0.1 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EEA27402.1 - 0.1 11.4 0.0 0.1 11.4 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase RIO1 PF01163.22 EEA27402.1 - 0.12 11.9 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Glyco_hydro_18 PF00704.28 EEA27403.1 - 5.6e-44 151.1 3.7 8.6e-44 150.5 3.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EEA27403.1 - 1.8e-08 34.3 0.1 0.0028 17.7 0.0 2.7 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EEA27403.1 - 1.3e-06 28.7 8.9 1.3e-06 28.7 8.9 3.6 2 1 1 3 3 3 1 Chitin recognition protein DUF1080 PF06439.11 EEA27404.1 - 1.1e-13 51.7 0.5 5.4e-08 33.2 0.1 2.2 2 0 0 2 2 2 2 Domain of Unknown Function (DUF1080) Laminin_G_2 PF02210.24 EEA27404.1 - 6.4e-05 23.5 0.1 0.57 10.8 0.0 2.5 2 0 0 2 2 2 2 Laminin G domain DUF3439 PF11921.8 EEA27404.1 - 0.41 10.6 7.5 1.2 9.1 7.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) RAP1 PF07218.11 EEA27404.1 - 4.3 5.5 8.9 7.1 4.8 8.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ATP-synt_D PF01813.17 EEA27406.1 - 0.096 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 ATP synthase subunit D Ins_allergen_rp PF06757.13 EEA27406.1 - 0.13 12.2 0.3 0.22 11.5 0.3 1.3 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification NAD_binding_8 PF13450.6 EEA27407.1 - 4.6e-08 33.2 0.0 1e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EEA27407.1 - 1.2e-06 28.2 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EEA27407.1 - 0.0053 16.0 0.1 0.021 14.0 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA27407.1 - 0.0059 15.9 0.1 0.0092 15.3 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA27407.1 - 0.015 14.6 0.0 0.029 13.6 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EEA27407.1 - 0.021 14.2 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 EEA27407.1 - 0.026 13.8 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 EEA27407.1 - 0.032 13.8 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EEA27407.1 - 0.16 11.0 0.1 0.29 10.1 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein TrkA_N PF02254.18 EEA27407.1 - 0.17 12.2 0.0 0.43 10.9 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain HI0933_like PF03486.14 EEA27407.1 - 0.2 10.3 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein DDE_3 PF13358.6 EEA27408.1 - 3.1e-11 43.2 0.2 7e-11 42.1 0.2 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA27408.1 - 0.00039 20.6 0.2 0.0012 19.0 0.2 1.8 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA27408.1 - 0.00061 19.5 1.4 0.0035 17.1 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_32 PF13565.6 EEA27408.1 - 0.0015 19.1 6.6 0.082 13.5 1.0 3.2 1 1 2 3 3 3 2 Homeodomain-like domain DUF4350 PF14258.6 EEA27408.1 - 0.0026 18.2 0.1 7.1 7.1 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4350) HTH_12 PF08461.10 EEA27408.1 - 0.0043 17.0 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA27408.1 - 0.0051 16.5 0.1 0.014 15.2 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_33 PF13592.6 EEA27408.1 - 0.018 14.6 2.0 3.7 7.3 0.1 3.1 3 1 0 3 3 3 0 Winged helix-turn helix HTH_7 PF02796.15 EEA27408.1 - 0.021 14.9 0.0 5.1 7.3 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Cytochrom_C PF00034.21 EEA27408.1 - 0.075 14.2 0.4 0.59 11.3 0.0 2.5 2 2 0 2 2 2 0 Cytochrome c NTase_sub_bind PF08780.11 EEA27408.1 - 0.088 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like Sigma70_r4_2 PF08281.12 EEA27408.1 - 0.092 12.4 0.5 0.33 10.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 DUF2774 PF11242.8 EEA27408.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) TPT PF03151.16 EEA27409.1 - 6.8e-25 88.0 25.2 8.4e-25 87.7 25.2 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family TPT PF03151.16 EEA27410.1 - 6.8e-25 88.0 25.2 8.4e-25 87.7 25.2 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family TFIIB PF00382.19 EEA27412.1 - 4.7e-35 119.5 1.4 1.9e-18 66.3 0.2 2.8 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EEA27412.1 - 7.7e-27 93.6 0.0 7.7e-27 93.6 0.0 3.9 3 1 1 4 4 4 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 EEA27412.1 - 0.0028 17.4 0.2 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain TF_Zn_Ribbon PF08271.12 EEA27412.1 - 0.0032 16.9 3.4 0.0072 15.8 3.4 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding E1-E2_ATPase PF00122.20 EEA27413.1 - 4e-53 179.6 7.5 4.3e-53 179.5 0.7 3.1 4 0 0 4 4 4 1 E1-E2 ATPase HMA PF00403.26 EEA27413.1 - 2.2e-52 175.3 11.5 7e-14 52.0 0.0 5.9 5 0 0 5 5 5 5 Heavy-metal-associated domain Hydrolase PF00702.26 EEA27413.1 - 3.8e-34 118.8 0.1 6.5e-34 118.1 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EEA27413.1 - 5.8e-07 29.5 0.6 0.00046 20.0 0.1 2.6 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF1269 PF06897.12 EEA27413.1 - 0.0023 18.2 0.5 0.12 12.7 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1269) RRM_3 PF08777.11 EEA27413.1 - 0.022 14.8 0.1 26 4.9 0.0 3.9 5 0 0 5 5 5 0 RNA binding motif HAD PF12710.7 EEA27413.1 - 0.066 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Fer2_BFD PF04324.15 EEA27413.1 - 1.6 9.2 14.2 22 5.5 0.5 5.7 5 1 0 5 5 5 0 BFD-like [2Fe-2S] binding domain ERCC4 PF02732.15 EEA27414.1 - 2.2e-27 96.1 0.0 3.5e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain Ish1 PF10281.9 EEA27414.1 - 0.11 12.9 0.3 0.45 10.9 0.0 2.3 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein DUF3292 PF11696.8 EEA27415.1 - 2e-36 125.7 0.3 2.1e-36 125.6 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) DUF3292 PF11696.8 EEA27416.1 - 3.5e-176 587.4 0.3 3e-175 584.3 0.3 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3292) DUF3005 PF11448.8 EEA27416.1 - 0.072 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) Epimerase PF01370.21 EEA27417.1 - 3.2e-23 82.4 0.0 4.2e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA27417.1 - 7.8e-20 71.5 0.0 1.8e-19 70.3 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EEA27417.1 - 8e-11 41.5 0.0 9.8e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EEA27417.1 - 5.2e-08 32.3 0.0 7.7e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EEA27417.1 - 7e-07 28.7 0.1 0.042 13.0 0.1 2.5 2 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EEA27417.1 - 4.9e-05 23.3 0.0 7.6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EEA27417.1 - 0.00012 22.1 0.0 0.011 15.6 0.0 2.4 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EEA27417.1 - 0.0016 17.6 0.0 0.014 14.6 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EEA27417.1 - 0.0035 16.8 0.0 0.016 14.7 0.0 2.0 1 1 1 2 2 2 1 short chain dehydrogenase Ldh_1_N PF00056.23 EEA27417.1 - 0.0042 17.2 0.0 0.0075 16.4 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain SHNi-TPR PF10516.9 EEA27417.1 - 0.069 12.6 0.2 0.14 11.7 0.2 1.5 1 0 0 1 1 1 0 SHNi-TPR Zn_clus PF00172.18 EEA27418.1 - 4.9e-06 26.6 10.7 9.1e-06 25.7 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA27418.1 - 8.3e-06 25.0 0.8 3.6e-05 22.9 0.8 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain YhhN PF07947.14 EEA27418.1 - 0.17 11.5 1.1 0.4 10.3 0.3 1.8 2 0 0 2 2 2 0 YhhN family ChAPs PF09295.10 EEA27420.1 - 1.3e-153 511.7 0.0 1.7e-153 511.4 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 EEA27420.1 - 2e-08 34.3 5.0 0.028 15.2 0.0 5.1 3 2 2 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA27420.1 - 4.6e-07 29.4 0.7 0.0017 18.3 0.1 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA27420.1 - 1.6e-06 27.7 0.1 0.019 14.8 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA27420.1 - 4e-06 27.2 0.8 0.27 11.8 0.1 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA27420.1 - 5.3e-05 23.1 0.1 0.022 15.0 0.0 4.0 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA27420.1 - 0.00047 20.4 2.3 0.66 10.3 0.3 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA27420.1 - 0.0036 17.2 0.5 0.39 10.9 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EEA27420.1 - 0.0037 16.5 0.4 0.26 10.5 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EEA27420.1 - 0.032 14.4 0.1 1.8 8.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA27420.1 - 0.27 11.9 1.6 62 4.3 0.1 3.5 3 2 2 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EEA27421.1 - 0.052 13.2 0.2 0.22 11.2 0.2 2.1 1 0 0 1 1 1 0 TPR repeat TPR_19 PF14559.6 EEA27421.1 - 0.059 13.9 0.5 21 5.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat MttA_Hcf106 PF02416.16 EEA27421.1 - 0.19 11.1 0.0 0.44 9.9 0.0 1.6 1 0 0 1 1 1 0 mttA/Hcf106 family TPR_1 PF00515.28 EEA27421.1 - 0.34 10.8 1.5 5.6 7.0 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA27421.1 - 7.1 7.7 9.3 20 6.3 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Kinesin PF00225.23 EEA27422.1 - 2.3e-60 204.3 0.2 3.4e-60 203.7 0.2 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EEA27422.1 - 1.4e-12 47.8 0.0 5.3e-11 42.7 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding AAA_13 PF13166.6 EEA27422.1 - 0.00069 18.4 1.8 0.001 17.8 1.8 1.2 1 0 0 1 1 1 1 AAA domain CCDC106 PF15794.5 EEA27422.1 - 0.0049 16.6 1.7 0.01 15.5 0.7 2.0 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 106 bZIP_2 PF07716.15 EEA27422.1 - 0.0063 16.6 1.0 0.021 14.9 1.0 2.0 1 0 0 1 1 1 1 Basic region leucine zipper DUF2737 PF10930.8 EEA27422.1 - 0.36 10.4 1.4 4 7.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2737) APG6_N PF17675.1 EEA27422.1 - 0.38 11.3 17.0 0.95 10.0 5.9 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region Stathmin PF00836.19 EEA27422.1 - 0.57 10.1 8.1 1.7 8.7 8.1 1.7 1 0 0 1 1 1 0 Stathmin family Fungal_trans PF04082.18 EEA27423.1 - 3.1e-07 29.7 0.1 4.5e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 EEA27424.1 - 5.7e-34 117.3 0.8 1.2e-33 116.2 0.8 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA27424.1 - 5.7e-29 101.3 0.2 1.1e-28 100.4 0.2 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA27424.1 - 3.8e-10 40.0 0.3 5.7e-10 39.4 0.3 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA27424.1 - 0.002 18.0 0.2 0.0029 17.5 0.2 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EEA27424.1 - 0.0074 15.8 0.6 0.027 13.9 0.6 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family IlvN PF07991.12 EEA27424.1 - 0.055 13.0 0.2 0.089 12.4 0.2 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain zf-PARP PF00645.18 EEA27425.1 - 1.2e-20 74.1 0.3 1.2e-20 74.1 0.3 2.5 3 1 0 3 3 3 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DUF1168 PF06658.12 EEA27426.1 - 6.2e-39 132.9 11.3 9.7e-39 132.3 11.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Lyase_catalyt PF09093.11 EEA27426.1 - 0.041 13.0 0.0 0.061 12.5 0.0 1.1 1 0 0 1 1 1 0 Lyase, catalytic LRIF1 PF15741.5 EEA27426.1 - 0.069 11.7 6.1 0.082 11.4 6.1 1.1 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 PPL5 PF18168.1 EEA27426.1 - 0.37 10.0 4.4 0.5 9.6 4.4 1.1 1 0 0 1 1 1 0 Prim-pol family 5 RR_TM4-6 PF06459.12 EEA27426.1 - 1.5 8.6 9.1 2 8.1 9.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EEA27426.1 - 2.2 6.5 12.0 2.8 6.1 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 EEA27426.1 - 5.2 5.7 7.9 6.2 5.5 7.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cpn60_TCP1 PF00118.24 EEA27427.1 - 1.9e-175 584.2 0.8 2.2e-175 584.0 0.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PikAIV_N PF18605.1 EEA27428.1 - 1.4 8.6 9.4 2.2 7.9 2.3 2.5 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain BCS1_N PF08740.11 EEA27429.1 - 1.3e-47 162.2 0.5 1.8e-47 161.8 0.5 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EEA27429.1 - 2.7e-17 63.4 0.0 4.8e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA27429.1 - 8.4e-05 23.0 0.0 0.00021 21.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EEA27429.1 - 0.0052 17.0 0.0 0.0091 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EEA27429.1 - 0.0057 17.2 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EEA27429.1 - 0.0084 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 EEA27429.1 - 0.013 14.7 0.0 0.022 13.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 EEA27429.1 - 0.021 14.8 0.0 0.069 13.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 EEA27429.1 - 0.024 14.4 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EEA27429.1 - 0.029 14.9 0.0 0.063 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA27429.1 - 0.041 14.2 0.0 0.097 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EEA27429.1 - 0.048 13.2 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EEA27429.1 - 0.054 13.9 0.0 0.16 12.3 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 EEA27429.1 - 0.071 12.7 0.0 0.44 10.1 0.0 2.1 1 1 1 2 2 2 0 AAA domain Rad17 PF03215.15 EEA27429.1 - 0.081 12.8 0.0 0.39 10.6 0.0 2.0 2 0 0 2 2 2 0 Rad17 P-loop domain NACHT PF05729.12 EEA27429.1 - 0.16 11.9 0.0 0.56 10.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Viral_helicase1 PF01443.18 EEA27429.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EEA27429.1 - 0.19 11.5 0.0 0.42 10.4 0.0 1.5 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 EEA27431.1 - 5.9e-13 49.5 0.0 9.2e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EEA27431.1 - 5.1e-05 23.2 1.2 0.0026 17.6 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA27431.1 - 0.00013 21.5 0.0 0.00015 21.3 0.0 1.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain CFEM PF05730.11 EEA27432.1 - 0.002 18.2 9.0 0.002 18.2 9.0 2.1 2 0 0 2 2 2 1 CFEM domain SOG2 PF10428.9 EEA27432.1 - 0.016 14.4 17.1 0.018 14.3 17.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein KAR9 PF08580.10 EEA27432.1 - 1.8 7.0 10.3 1.9 6.9 10.3 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 RabGAP-TBC PF00566.18 EEA27433.1 - 3.7e-33 115.0 0.0 6e-32 111.1 0.0 2.3 1 1 0 1 1 1 1 Rab-GTPase-TBC domain UQ_con PF00179.26 EEA27434.1 - 2.8e-41 140.4 0.0 3.2e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA27434.1 - 1.5e-07 31.2 0.0 1.8e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EEA27434.1 - 0.052 13.8 0.1 0.075 13.3 0.1 1.5 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 EEA27434.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.6 2 0 0 2 2 2 0 UEV domain Peptidase_S24 PF00717.23 EEA27435.1 - 4.4e-07 29.8 0.0 6.9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like Proteasome PF00227.26 EEA27437.1 - 7e-51 172.4 0.0 1e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA27437.1 - 1.5e-12 46.9 0.2 2.5e-12 46.2 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Amidase_5 PF05382.13 EEA27437.1 - 0.0073 16.2 0.0 2.9 7.8 0.0 2.2 2 0 0 2 2 2 2 Bacteriophage peptidoglycan hydrolase DUF2373 PF10180.9 EEA27438.1 - 1.2e-22 79.5 0.5 2.3e-22 78.6 0.1 1.7 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2373) LAP1C PF05609.12 EEA27438.1 - 8.9 5.3 32.8 0.35 9.9 24.0 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) GCP_C_terminal PF04130.13 EEA27439.1 - 9.9e-102 340.5 1.2 2e-101 339.5 1.2 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EEA27439.1 - 2.7e-85 286.7 0.1 2.8e-84 283.4 0.0 2.2 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal Aft1_HRA PF11786.8 EEA27440.1 - 6.7e-25 87.2 8.2 6.7e-25 87.2 8.2 2.8 2 1 1 3 3 3 1 Aft1 HRA domain Aft1_HRR PF11787.8 EEA27440.1 - 2.4e-23 83.1 4.9 2.4e-23 83.1 4.9 3.4 3 1 0 3 3 3 1 Aft1 HRR domain Aft1_OSA PF11785.8 EEA27440.1 - 1.9e-19 69.8 16.4 2.9e-19 69.2 13.4 2.7 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EEA27440.1 - 7.5e-13 48.4 4.7 1.5e-12 47.4 4.7 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EEA27440.1 - 1.2e-05 25.3 5.4 2.6e-05 24.2 5.4 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EEA27440.1 - 0.0017 18.8 1.9 0.0043 17.5 1.9 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor Macoilin PF09726.9 EEA27440.1 - 1 7.8 9.6 1.3 7.5 9.6 1.1 1 0 0 1 1 1 0 Macoilin family Aft1_HRA PF11786.8 EEA27441.1 - 5.4e-25 87.5 8.2 5.4e-25 87.5 8.2 2.7 2 1 1 3 3 3 1 Aft1 HRA domain Aft1_HRR PF11787.8 EEA27441.1 - 2e-23 83.3 4.9 2e-23 83.3 4.9 3.3 3 1 0 3 3 3 1 Aft1 HRR domain Aft1_OSA PF11785.8 EEA27441.1 - 1.1e-19 70.6 16.1 2.5e-19 69.5 13.4 2.8 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EEA27441.1 - 4.3e-12 45.9 2.9 8.8e-12 44.9 2.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EEA27441.1 - 1e-05 25.5 5.4 2.2e-05 24.5 5.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EEA27441.1 - 0.0013 19.2 1.4 0.0034 17.9 1.4 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor Suf PF05843.14 EEA27444.1 - 7.2e-91 305.2 11.5 2.4e-89 300.2 0.0 4.1 5 0 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EEA27444.1 - 3.5e-05 24.2 3.7 0.55 11.2 0.0 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat HAT PF02184.16 EEA27444.1 - 0.0011 18.9 0.2 0.021 14.8 0.2 2.9 3 0 0 3 3 3 1 HAT (Half-A-TPR) repeat TPR_16 PF13432.6 EEA27444.1 - 0.0038 17.8 0.4 0.078 13.6 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat ASF1_hist_chap PF04729.13 EEA27445.1 - 1.8e-74 248.8 0.0 2.6e-74 248.3 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 EEA27445.1 - 0.0077 14.5 18.5 0.01 14.1 18.5 1.0 1 0 0 1 1 1 1 Nop14-like family Lgl_C PF08596.10 EEA27446.1 - 2.5e-131 438.0 0.0 9.5e-131 436.1 0.0 1.9 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 EEA27446.1 - 0.0015 18.8 0.0 6.2 7.2 0.0 5.2 5 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA27446.1 - 0.015 16.1 3.2 15 6.6 0.0 4.8 5 0 0 5 5 5 0 WD domain, G-beta repeat Nup160 PF11715.8 EEA27446.1 - 0.048 12.3 0.1 3.2 6.3 0.0 3.0 3 1 1 4 4 4 0 Nucleoporin Nup120/160 ABC_tran PF00005.27 EEA27447.1 - 1.6e-44 151.7 0.0 7.2e-21 75.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA27447.1 - 2.5e-28 99.5 30.1 1.1e-25 90.9 13.2 2.8 3 0 0 3 3 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EEA27447.1 - 2.7e-09 37.3 5.3 0.0086 15.9 0.0 4.8 3 2 2 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA27447.1 - 3.6e-09 36.4 0.7 0.21 11.0 0.0 4.4 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA27447.1 - 1.5e-08 35.0 0.1 0.0058 16.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EEA27447.1 - 4.2e-07 29.6 0.9 0.025 14.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EEA27447.1 - 4.8e-07 29.8 0.3 0.0038 17.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EEA27447.1 - 1.3e-06 29.0 0.4 0.11 12.8 0.1 3.5 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 EEA27447.1 - 4.7e-06 26.7 0.1 0.15 12.1 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EEA27447.1 - 1.7e-05 25.4 0.5 0.089 13.3 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EEA27447.1 - 0.00015 22.3 0.0 0.22 12.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EEA27447.1 - 0.00017 20.7 0.2 0.047 12.8 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 EEA27447.1 - 0.00019 21.0 0.1 0.42 10.1 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region Dynamin_N PF00350.23 EEA27447.1 - 0.00077 19.6 0.2 0.78 9.8 0.1 2.4 2 0 0 2 2 2 2 Dynamin family DUF87 PF01935.17 EEA27447.1 - 0.00079 19.6 1.0 0.011 15.8 0.1 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_15 PF13175.6 EEA27447.1 - 0.00098 18.9 0.0 0.52 10.0 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EEA27447.1 - 0.0012 19.3 0.0 1.1 9.7 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EEA27447.1 - 0.0013 18.3 0.1 0.075 12.6 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EEA27447.1 - 0.0015 18.7 0.0 0.36 11.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.7 EEA27447.1 - 0.0027 16.7 0.0 0.47 9.3 0.0 2.2 2 0 0 2 2 2 1 AAA-like domain Adeno_IVa2 PF02456.15 EEA27447.1 - 0.0041 16.0 0.1 2.2 7.0 0.0 2.2 2 0 0 2 2 2 2 Adenovirus IVa2 protein Zeta_toxin PF06414.12 EEA27447.1 - 0.0058 15.9 0.0 0.64 9.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin SbcCD_C PF13558.6 EEA27447.1 - 0.0075 16.5 3.3 0.38 11.0 0.2 3.6 3 1 0 3 3 3 1 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.18 EEA27447.1 - 0.019 14.3 0.2 1.6 8.1 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_27 PF13514.6 EEA27447.1 - 0.021 14.4 0.0 0.077 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA27447.1 - 0.024 14.3 0.6 9.9 5.9 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF815 PF05673.13 EEA27447.1 - 0.027 13.6 0.1 3.8 6.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 EEA27447.1 - 0.028 13.8 0.2 4.6 6.6 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EEA27447.1 - 0.038 13.7 0.5 1.1 9.0 0.1 2.5 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EEA27447.1 - 0.039 14.4 0.1 9.7 6.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ATP_bind_1 PF03029.17 EEA27447.1 - 0.046 13.5 0.2 0.84 9.4 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein TsaE PF02367.17 EEA27447.1 - 0.057 13.4 0.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EEA27447.1 - 0.095 12.7 0.1 31 4.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) GTP_EFTU PF00009.27 EEA27447.1 - 0.13 11.8 0.0 7 6.1 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Cytidylate_kin PF02224.18 EEA27447.1 - 0.13 12.0 0.1 5.8 6.6 0.1 2.3 2 0 0 2 2 2 0 Cytidylate kinase AAA_25 PF13481.6 EEA27447.1 - 0.16 11.6 1.6 5.7 6.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain Guanylate_kin PF00625.21 EEA27447.1 - 0.17 11.6 0.2 0.39 10.4 0.0 1.7 2 0 0 2 2 1 0 Guanylate kinase Roc PF08477.13 EEA27447.1 - 0.18 12.0 0.1 27 5.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EEA27447.1 - 0.2 11.4 0.7 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation APH PF01636.23 EEA27448.1 - 0.0017 18.4 0.0 0.0047 16.9 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family THUMP PF02926.17 EEA27449.1 - 1.5e-11 44.6 0.2 2.2e-11 44.1 0.2 1.3 1 0 0 1 1 1 1 THUMP domain DUF4611 PF15387.6 EEA27449.1 - 0.048 13.9 1.8 0.093 13.0 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Cwf_Cwc_15 PF04889.12 EEA27449.1 - 0.058 13.1 2.9 0.09 12.5 2.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 EEA27449.1 - 0.38 11.2 4.9 0.12 12.8 1.7 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal THUMP PF02926.17 EEA27450.1 - 1.5e-11 44.6 0.2 2.2e-11 44.1 0.2 1.3 1 0 0 1 1 1 1 THUMP domain DUF4611 PF15387.6 EEA27450.1 - 0.048 13.9 1.8 0.093 13.0 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Cwf_Cwc_15 PF04889.12 EEA27450.1 - 0.058 13.1 2.9 0.09 12.5 2.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 EEA27450.1 - 0.38 11.2 4.9 0.12 12.8 1.7 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal THUMP PF02926.17 EEA27451.1 - 7.7e-12 45.5 0.1 1.3e-11 44.8 0.1 1.3 1 1 0 1 1 1 1 THUMP domain Cwf_Cwc_15 PF04889.12 EEA27451.1 - 0.16 11.7 4.4 0.23 11.2 4.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 EEA27451.1 - 1.1 9.7 6.1 0.43 11.0 3.1 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TPP_enzyme_N PF02776.18 EEA27452.1 - 5.4e-31 107.5 0.0 9.5e-31 106.7 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA27452.1 - 3.4e-23 81.9 0.0 9.1e-22 77.3 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EEA27452.1 - 3.6e-13 49.6 0.0 7.4e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 EEA27452.1 - 0.072 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Dehydrogenase E1 component Pkinase PF00069.25 EEA27453.1 - 7.5e-63 212.3 0.0 1.1e-62 211.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27453.1 - 2.4e-43 148.3 0.0 3.6e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA27453.1 - 9.5e-10 38.2 0.0 3.7e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EEA27453.1 - 0.0009 18.1 0.4 0.0054 15.5 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EEA27453.1 - 0.0075 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA27453.1 - 0.018 15.0 0.0 0.26 11.2 0.0 2.6 3 0 0 3 3 3 0 Phosphotransferase enzyme family SAM_3 PF18016.1 EEA27453.1 - 0.13 12.1 0.2 0.36 10.7 0.2 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Sec34 PF04136.15 EEA27454.1 - 1.9e-50 170.6 0.8 1.9e-50 170.6 0.8 1.8 3 0 0 3 3 3 1 Sec34-like family RCC1 PF00415.18 EEA27455.1 - 2.3e-29 101.8 0.8 2.4e-06 28.1 0.0 6.8 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA27455.1 - 3.5e-20 71.3 17.6 3.7e-11 42.5 0.1 7.4 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat DNA_gyraseA_C PF03989.13 EEA27455.1 - 0.11 12.0 0.0 8.7 5.9 0.0 2.7 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller Peptidase_S80 PF07230.11 EEA27455.1 - 0.21 9.8 0.0 0.31 9.3 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage T4-like capsid assembly protein (Gp20) PUF PF00806.19 EEA27456.1 - 4e-19 67.2 0.0 0.03 14.0 0.0 8.9 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat CP2 PF04516.15 EEA27457.1 - 1.4e-81 273.2 0.0 2.1e-81 272.6 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor PTRF_SDPR PF15237.6 EEA27457.1 - 0.034 13.8 0.2 0.11 12.2 0.2 1.7 2 0 0 2 2 2 0 PTRF/SDPR family AKNA PF12443.8 EEA27457.1 - 0.038 14.6 0.0 0.13 13.0 0.0 1.9 1 0 0 1 1 1 0 AT-hook-containing transcription factor Metallopep PF12044.8 EEA27458.1 - 4.6e-168 559.3 0.0 5.8e-168 558.9 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 EEA27458.1 - 0.0093 15.9 0.0 0.13 12.2 0.0 2.1 1 1 1 2 2 2 1 Jacalin-like lectin domain Reprolysin_3 PF13582.6 EEA27458.1 - 0.26 11.8 0.9 0.59 10.7 0.9 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like p450 PF00067.22 EEA27459.1 - 0.1 11.3 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 FAD_binding_4 PF01565.23 EEA27460.1 - 2.4e-29 101.8 0.0 4.3e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EEA27460.1 - 3.5e-08 33.4 0.0 4.9e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain MFS_1 PF07690.16 EEA27461.1 - 5.8e-20 71.5 25.1 5.8e-20 71.5 25.1 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA27461.1 - 5.7e-08 31.6 2.0 1e-07 30.8 2.0 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) COesterase PF00135.28 EEA27462.1 - 1.4e-59 202.3 0.0 1.9e-59 201.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA27462.1 - 4.6e-06 26.6 0.0 0.052 13.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA27462.1 - 0.0003 21.5 0.0 0.00047 20.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EEA27462.1 - 0.017 14.8 0.6 0.21 11.2 0.6 2.2 1 1 0 1 1 1 0 Putative esterase DUF1039 PF06287.11 EEA27462.1 - 0.054 13.9 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1039) Cyclase PF04199.13 EEA27463.1 - 6.7e-15 55.5 0.0 1e-14 55.0 0.0 1.3 1 0 0 1 1 1 1 Putative cyclase FAD_binding_3 PF01494.19 EEA27464.1 - 1.6e-42 146.0 0.0 2.6e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA27464.1 - 9.2e-06 25.5 0.0 0.058 13.0 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EEA27464.1 - 0.00016 21.2 0.0 0.00091 18.7 0.0 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA27464.1 - 0.00046 19.0 0.0 0.0046 15.7 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EEA27464.1 - 0.00088 19.5 0.0 0.0028 17.9 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA27464.1 - 0.0014 18.0 0.0 0.0024 17.1 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA27464.1 - 0.0019 18.7 0.1 0.24 12.0 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA27464.1 - 0.0019 17.5 0.0 0.12 11.6 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EEA27464.1 - 0.0087 15.4 0.0 0.053 12.8 0.0 2.0 1 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EEA27464.1 - 0.042 12.9 0.1 3.2 6.7 0.2 2.1 1 1 1 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 EEA27464.1 - 0.055 13.4 0.1 2.2 8.2 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EEA27464.1 - 0.11 11.5 0.3 0.22 10.6 0.2 1.4 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 EEA27464.1 - 0.18 11.0 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family RVT_2 PF07727.14 EEA27466.1 - 9.1e-11 41.9 0.0 1.6e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA27466.1 - 1.4e-07 31.7 0.3 5.6e-06 26.5 0.0 3.0 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 EEA27466.1 - 0.00022 21.0 0.2 0.00073 19.4 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain PAC4 PF16093.5 EEA27466.1 - 0.14 12.4 0.0 0.73 10.1 0.0 2.3 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Integrase_H2C2 PF17921.1 EEA27466.1 - 0.76 9.9 8.7 0.46 10.6 0.1 3.7 3 0 0 3 3 3 0 Integrase zinc binding domain FAD_binding_4 PF01565.23 EEA27467.1 - 2.4e-27 95.4 0.2 3.6e-27 94.8 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain p450 PF00067.22 EEA27467.1 - 3e-08 32.9 0.0 2.1e-07 30.1 0.0 2.0 2 0 0 2 2 2 1 Cytochrome P450 BBE PF08031.12 EEA27467.1 - 0.0039 17.3 0.0 0.0097 16.0 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Whi5 PF08528.11 EEA27468.1 - 0.17 11.5 0.3 0.32 10.6 0.3 1.4 1 0 0 1 1 1 0 Whi5 like DNA_ligase_A_M PF01068.21 EEA27469.1 - 4.5e-51 173.4 0.3 5e-48 163.4 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EEA27469.1 - 2.8e-37 128.7 0.0 6.7e-37 127.5 0.0 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EEA27469.1 - 6.3e-20 71.6 0.0 1.9e-19 70.1 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EEA27469.1 - 0.00027 21.3 0.0 0.00064 20.1 0.0 1.6 1 0 0 1 1 1 1 RNA ligase RINT1_TIP1 PF04437.13 EEA27470.1 - 6e-181 602.7 0.1 1.2e-180 601.7 0.1 1.5 1 0 0 1 1 1 1 RINT-1 / TIP-1 family ISG65-75 PF11727.8 EEA27470.1 - 0.43 9.8 2.5 0.97 8.6 2.5 1.5 1 0 0 1 1 1 0 Invariant surface glycoprotein T3SSipB PF16535.5 EEA27470.1 - 4.3 7.8 13.2 19 5.7 12.9 2.1 1 1 0 1 1 1 0 Type III cell invasion protein SipB Pyridoxal_deC PF00282.19 EEA27471.1 - 6e-78 262.2 0.0 1.3e-76 257.7 0.0 2.4 2 1 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Dabb PF07876.12 EEA27471.1 - 2e-12 47.6 0.0 5.6e-12 46.1 0.0 1.8 2 0 0 2 2 2 1 Stress responsive A/B Barrel Domain Aminotran_5 PF00266.19 EEA27471.1 - 6.5e-06 25.3 0.0 1.2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA27471.1 - 0.00017 21.0 0.0 0.00028 20.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DUF1541 PF07563.11 EEA27471.1 - 1.3 8.9 3.6 10 6.1 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) Clathrin PF00637.20 EEA27472.1 - 2.9e-20 72.6 2.4 1.1e-19 70.8 0.5 2.7 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.9 EEA27472.1 - 0.00064 20.0 0.3 0.12 12.7 0.2 2.7 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Coatomer_WDAD PF04053.14 EEA27472.1 - 0.03 13.4 0.2 29 3.5 0.0 3.7 4 0 0 4 4 4 0 Coatomer WD associated region SpoIIIAH PF12685.7 EEA27472.1 - 0.2 11.5 5.0 0.36 10.6 2.5 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein zf-RING_5 PF14634.6 EEA27472.1 - 1.3 9.0 4.9 0.49 10.4 1.7 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 EEA27472.1 - 1.3 8.8 7.1 0.25 11.1 3.1 1.9 2 0 0 2 2 2 0 RING-like zinc finger DUF4746 PF15928.5 EEA27472.1 - 1.6 8.1 12.3 3.8 6.8 12.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) zf-RING_2 PF13639.6 EEA27472.1 - 1.9 8.9 5.9 0.4 11.1 1.7 2.1 2 0 0 2 2 2 0 Ring finger domain CPSF100_C PF13299.6 EEA27472.1 - 2.8 8.1 4.3 4.4 7.5 2.2 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal BUD22 PF09073.10 EEA27472.1 - 7.7 5.7 18.8 1.5 8.1 14.7 1.7 2 0 0 2 2 2 0 BUD22 NOA36 PF06524.12 EEA27472.1 - 8.3 5.6 25.3 18 4.6 25.3 1.5 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.13 EEA27472.1 - 10 6.0 16.9 25 4.6 16.9 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF155 PF02582.14 EEA27473.1 - 3.2e-49 167.4 0.0 4.8e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Ribonuclease_T2 PF00445.18 EEA27474.1 - 5.6e-41 140.8 0.0 1.1e-40 139.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease T2 family zf-H2C2_2 PF13465.6 EEA27475.1 - 5.9e-09 36.0 11.8 0.00042 20.6 0.1 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EEA27475.1 - 2.2e-06 27.8 23.6 0.016 15.6 6.2 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA27475.1 - 0.00053 20.6 21.2 0.1 13.5 5.0 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EEA27475.1 - 0.71 9.7 6.3 8.1 6.3 1.8 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Bunya_G2 PF03563.13 EEA27475.1 - 1.7 7.8 3.7 2.7 7.2 3.7 1.2 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 ubiquitin PF00240.23 EEA27476.1 - 4.5e-34 116.0 0.6 7.9e-34 115.2 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EEA27476.1 - 1.2e-26 92.6 2.7 1.2e-26 92.6 2.7 2.0 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EEA27476.1 - 2.6e-16 59.2 0.7 4.9e-16 58.3 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA27476.1 - 2.8e-05 24.5 0.4 0.00013 22.4 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA27476.1 - 0.0011 19.0 0.6 0.0026 17.8 0.6 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EEA27476.1 - 0.0047 17.2 0.9 0.0079 16.5 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EEA27476.1 - 0.0054 16.6 0.0 0.0082 16.1 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EEA27476.1 - 0.013 16.1 0.7 0.019 15.6 0.7 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EEA27476.1 - 0.021 14.9 1.0 5.9 7.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain DUF971 PF06155.12 EEA27476.1 - 0.1 13.2 0.0 0.19 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF971) Glyco_hydro_18 PF00704.28 EEA27477.1 - 2.4e-86 290.3 1.1 2.7e-86 290.1 1.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Imm10 PF15588.6 EEA27477.1 - 0.16 12.1 0.1 0.38 10.9 0.1 1.6 1 0 0 1 1 1 0 Immunity protein 10 Piwi PF02171.17 EEA27478.1 - 6.5e-68 229.2 0.2 1e-67 228.5 0.2 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EEA27478.1 - 9.4e-18 65.2 1.0 1.9e-17 64.2 0.2 2.0 2 0 0 2 2 2 1 N-terminal domain of argonaute PAZ PF02170.22 EEA27478.1 - 1.1e-13 51.2 0.8 2.6e-13 50.0 0.8 1.6 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 EEA27478.1 - 3.6e-12 45.7 0.0 8e-12 44.6 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoMid PF16487.5 EEA27478.1 - 3.6e-10 40.0 0.0 1.2e-09 38.3 0.0 1.9 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 EEA27478.1 - 1.1e-09 38.4 0.0 3.6e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 Argonaute linker 2 domain Cu_amine_oxid PF01179.20 EEA27478.1 - 0.073 12.0 0.6 1.3 7.9 0.2 2.2 2 0 0 2 2 2 0 Copper amine oxidase, enzyme domain Bromodomain PF00439.25 EEA27479.1 - 4.9e-18 65.0 2.1 8.5e-18 64.2 0.2 2.4 3 0 0 3 3 3 1 Bromodomain Bromo_TP PF07524.13 EEA27479.1 - 3.1e-08 33.5 0.0 1.3e-07 31.5 0.0 2.1 2 0 0 2 2 2 1 Bromodomain associated Bromo_TP_like PF17027.5 EEA27479.1 - 0.056 13.6 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Histone-fold protein Alpha-mann_mid PF09261.11 EEA27479.1 - 0.12 12.6 0.3 0.67 10.1 0.1 2.4 2 0 0 2 2 2 0 Alpha mannosidase middle domain VanZ PF04892.12 EEA27480.1 - 3.6e-07 30.9 1.6 6.5e-07 30.0 1.6 1.3 1 1 0 1 1 1 1 VanZ like family Virul_fac_BrkB PF03631.15 EEA27480.1 - 0.015 14.9 1.2 0.018 14.7 1.2 1.1 1 0 0 1 1 1 0 Virulence factor BrkB MFS_1 PF07690.16 EEA27480.1 - 0.091 11.7 1.4 0.12 11.3 1.4 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF2208 PF09973.9 EEA27480.1 - 0.43 10.2 1.5 0.53 9.9 1.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Y_phosphatase PF00102.27 EEA27481.1 - 8.9e-52 176.0 0.0 6.5e-51 173.2 0.0 1.9 1 1 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EEA27481.1 - 0.00027 21.1 0.1 0.00077 19.6 0.1 2.0 1 1 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EEA27481.1 - 0.00073 19.6 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EEA27481.1 - 0.014 15.2 0.2 0.08 12.8 0.0 2.1 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain LCM PF04072.14 EEA27481.1 - 0.07 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase Mid2 PF04478.12 EEA27482.1 - 6.8e-05 22.7 5.2 6.8e-05 22.7 5.2 2.3 1 1 1 3 3 3 1 Mid2 like cell wall stress sensor Ndc1_Nup PF09531.10 EEA27482.1 - 0.06 12.0 10.5 0.078 11.7 10.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TMEM154 PF15102.6 EEA27482.1 - 0.16 11.9 0.1 0.16 11.9 0.1 3.2 1 1 1 2 2 2 0 TMEM154 protein family Utp14 PF04615.13 EEA27482.1 - 0.26 9.8 3.4 0.27 9.7 3.4 1.1 1 0 0 1 1 1 0 Utp14 protein Pex19 PF04614.12 EEA27484.1 - 7.5e-55 186.4 10.0 7.5e-55 186.4 10.0 2.1 1 1 1 2 2 2 2 Pex19 protein family DUF1104 PF06518.11 EEA27484.1 - 0.064 13.6 7.3 2.7 8.4 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1104) bZIP_1 PF00170.21 EEA27485.1 - 1.3e-05 25.2 9.5 2.6e-05 24.2 9.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EEA27485.1 - 0.0034 17.4 9.4 0.011 15.8 9.4 1.9 1 0 0 1 1 1 1 Basic region leucine zipper Mit_KHE1 PF10173.9 EEA27485.1 - 0.12 12.4 0.4 0.18 11.9 0.4 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF4407 PF14362.6 EEA27485.1 - 0.3 10.4 3.2 1.6 8.0 3.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ABC_tran_Xtn PF12848.7 EEA27485.1 - 8.5 6.5 12.4 1.5 8.9 7.7 2.0 2 0 0 2 2 2 0 ABC transporter Stm1_N PF09598.10 EEA27486.1 - 9.4e-18 64.8 6.8 9.4e-18 64.8 6.8 4.1 4 3 0 4 4 4 1 Stm1 DUF1793 PF08760.11 EEA27487.1 - 8.7e-71 237.7 0.2 2.5e-70 236.2 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 EEA27487.1 - 9.9e-62 207.6 0.2 5.3e-48 162.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EEA27487.1 - 2e-41 142.3 2.3 3.1e-41 141.6 2.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 EEA27487.1 - 0.00021 20.8 0.0 0.0005 19.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) DEAD PF00270.29 EEA27489.1 - 2.9e-41 141.2 0.0 8.3e-41 139.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA27489.1 - 6.1e-31 107.0 0.0 2.3e-30 105.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA27489.1 - 2.7e-06 27.5 0.0 5.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EEA27489.1 - 0.069 12.8 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 SWI2/SNF2 ATPase SNF2_N PF00176.23 EEA27489.1 - 0.13 11.0 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain TFIIF_alpha PF05793.12 EEA27489.1 - 2 6.9 5.8 2.6 6.5 5.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RTA1 PF04479.13 EEA27490.1 - 3.8e-72 242.2 9.9 6e-72 241.6 9.9 1.3 1 0 0 1 1 1 1 RTA1 like protein AAA_16 PF13191.6 EEA27492.1 - 1.1e-08 35.7 0.2 2.9e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EEA27492.1 - 0.013 15.0 0.1 0.074 12.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain DUF2193 PF09959.9 EEA27492.1 - 0.013 13.9 0.0 0.019 13.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) AAA_5 PF07728.14 EEA27492.1 - 0.014 15.4 0.1 0.089 12.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EEA27492.1 - 0.019 14.5 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region CbiA PF01656.23 EEA27492.1 - 0.028 14.5 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EEA27492.1 - 0.041 14.2 0.2 0.12 12.7 0.2 1.7 1 1 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EEA27492.1 - 0.043 13.5 0.0 0.084 12.5 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 EEA27492.1 - 0.062 13.7 0.1 0.15 12.5 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2914 PF11141.8 EEA27492.1 - 0.078 12.7 0.4 0.28 11.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2914) DnaB_C PF03796.15 EEA27492.1 - 0.08 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain RsgA_GTPase PF03193.16 EEA27492.1 - 0.094 12.6 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase CLU PF13236.6 EEA27493.1 - 5.3e-75 252.1 0.0 1e-74 251.1 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EEA27493.1 - 1.2e-56 191.5 0.2 3.8e-56 189.9 0.0 2.0 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EEA27493.1 - 2.3e-26 91.9 9.1 8.6e-13 48.4 0.2 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 EEA27493.1 - 4.8e-25 87.7 0.4 1.9e-24 85.8 0.3 2.1 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 EEA27493.1 - 1.4e-23 82.0 3.0 3.4e-06 26.8 0.0 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA27493.1 - 0.00082 19.3 5.3 0.38 11.0 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA27493.1 - 0.0013 18.8 5.6 0.089 13.1 0.5 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF727 PF05303.12 EEA27493.1 - 0.0024 17.9 0.0 0.0069 16.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_17 PF13431.6 EEA27493.1 - 0.59 10.6 5.4 2.5e+02 2.4 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat BRF1 PF07741.13 EEA27493.1 - 2.9 8.3 8.3 16 5.9 3.0 2.9 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Hep_59 PF07052.11 EEA27493.1 - 9.4 7.0 8.7 3.7 8.3 3.5 2.7 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 GAPT PF11770.8 EEA27494.1 - 0.68 9.8 2.4 1.4 8.7 1.9 1.8 1 1 0 1 1 1 0 GRB2-binding adapter (GAPT) PPP4R2 PF09184.11 EEA27494.1 - 1 8.9 8.1 0.55 9.8 3.6 2.4 2 0 0 2 2 2 0 PPP4R2 Ferric_reduct PF01794.19 EEA27495.1 - 2.8e-20 72.7 15.1 3.2e-20 72.5 13.0 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EEA27495.1 - 1.7e-19 70.4 0.0 9.5e-11 42.1 0.0 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EEA27495.1 - 4.4e-13 49.3 0.0 1.6e-11 44.2 0.0 2.3 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EEA27495.1 - 0.026 15.2 0.0 0.15 12.7 0.1 2.3 2 1 0 2 2 2 0 Oxidoreductase NAD-binding domain GST_N PF02798.20 EEA27496.1 - 5.4e-16 58.7 0.0 9.6e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA27496.1 - 2.6e-14 53.4 0.0 5.7e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EEA27496.1 - 2.4e-11 43.7 0.0 4.9e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA27496.1 - 8.4e-11 41.9 0.0 1.7e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA27496.1 - 1.6e-10 41.0 0.0 3.3e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA27496.1 - 7.9e-08 32.2 0.0 1.8e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SF1-HH PF16275.5 EEA27497.1 - 1.5e-43 147.7 1.1 3.2e-43 146.7 1.1 1.5 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 EEA27497.1 - 6.6e-12 44.9 11.1 1.3e-05 25.0 0.8 2.3 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 EEA27497.1 - 8.7e-08 31.9 0.1 1.6e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 EEA27497.1 - 1.1e-06 28.5 5.5 0.0014 18.6 2.9 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EEA27497.1 - 0.0011 18.7 6.6 0.37 10.6 0.6 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EEA27497.1 - 0.0014 18.4 5.0 0.42 10.4 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 EEA27497.1 - 0.014 15.2 0.5 0.014 15.2 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle eIF3g PF12353.8 EEA27497.1 - 0.98 9.8 6.9 69 3.9 4.9 3.3 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G HCO3_cotransp PF00955.21 EEA27498.1 - 1.3e-84 284.9 16.2 1.5e-45 156.1 6.6 2.1 1 1 1 2 2 2 2 HCO3- transporter family XFP_N PF09364.10 EEA27499.1 - 1.3e-149 498.0 0.0 1.7e-149 497.6 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 EEA27499.1 - 2.1e-77 259.2 0.0 3.3e-77 258.5 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 EEA27499.1 - 4.5e-74 248.0 0.0 6.5e-74 247.4 0.0 1.2 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase TPP_enzyme_C PF02775.21 EEA27499.1 - 0.0046 16.7 0.1 0.0092 15.8 0.1 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain FAST_1 PF06743.15 EEA27499.1 - 0.068 13.1 0.3 16 5.6 0.0 2.7 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 Transket_pyr PF02779.24 EEA27499.1 - 0.09 12.4 0.1 0.27 10.9 0.1 1.7 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain Acetate_kinase PF00871.17 EEA27500.1 - 6.7e-97 324.6 0.0 8.1e-97 324.4 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family Acetate_kinase PF00871.17 EEA27501.1 - 9.2e-97 324.2 0.0 1.1e-96 323.9 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family Ras PF00071.22 EEA27502.1 - 6.3e-56 188.4 0.0 7.8e-56 188.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA27502.1 - 1.2e-33 115.8 0.0 1.8e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA27502.1 - 7.8e-13 48.2 0.0 1.7e-12 47.1 0.0 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA27502.1 - 4.7e-05 23.0 0.0 7e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EEA27502.1 - 0.00042 19.7 0.0 0.00054 19.4 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA27502.1 - 0.00043 20.3 0.0 0.00069 19.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EEA27502.1 - 0.002 18.5 0.0 0.0032 17.9 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA27502.1 - 0.14 12.0 0.1 2 8.3 0.0 2.4 3 0 0 3 3 3 0 RsgA GTPase Ribosomal_S7e PF01251.18 EEA27503.1 - 2e-81 272.2 0.1 2.3e-81 272.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Dynactin_p62 PF05502.13 EEA27504.1 - 1.1e-129 433.3 0.0 3.1e-129 431.9 0.0 1.5 1 1 0 1 1 1 1 Dynactin p62 family Methyltransf_11 PF08241.12 EEA27505.1 - 1.7e-11 44.6 0.0 4.3e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA27505.1 - 8.4e-10 38.7 0.0 1.3e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA27505.1 - 8e-08 32.9 0.0 1.7e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA27505.1 - 1.1e-07 32.4 0.0 3.3e-07 30.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA27505.1 - 0.00037 20.3 0.0 0.00094 19.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA27505.1 - 0.0018 17.6 0.0 0.0029 17.0 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family P16-Arc PF04699.14 EEA27506.1 - 8e-45 153.0 0.0 9.3e-45 152.8 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) P16-Arc PF04699.14 EEA27507.1 - 8e-45 153.0 0.0 9.3e-45 152.8 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) TENA_THI-4 PF03070.16 EEA27508.1 - 4.2e-12 46.3 0.0 2.4e-08 34.1 0.0 2.7 2 1 0 2 2 2 2 TENA/THI-4/PQQC family ING PF12998.7 EEA27510.1 - 2.2e-06 28.2 0.1 4.1e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EEA27510.1 - 2e-05 24.4 6.3 2e-05 24.4 6.3 1.8 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 EEA27510.1 - 0.05 13.9 0.5 0.1 12.8 0.5 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EEA27510.1 - 0.17 12.1 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain RTA1 PF04479.13 EEA27511.1 - 1.6e-70 236.9 2.4 2.4e-70 236.4 2.4 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF2207 PF09972.9 EEA27512.1 - 0.096 11.4 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Syndecan PF01034.20 EEA27512.1 - 0.52 10.3 2.2 0.5 10.3 0.4 1.9 2 0 0 2 2 2 0 Syndecan domain Apt1 PF10351.9 EEA27512.1 - 0.97 8.2 6.7 1.4 7.7 6.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4231 PF14015.6 EEA27512.1 - 8 7.0 6.0 5.5 7.5 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) EB1 PF03271.17 EEA27513.1 - 2.8e-17 62.6 0.7 5.4e-17 61.8 0.7 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EEA27513.1 - 1.8e-06 28.1 0.7 3e-06 27.4 0.7 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 EEA27513.1 - 0.0095 16.0 0.1 0.014 15.5 0.1 1.3 1 0 0 1 1 1 1 CH-like domain in sperm protein Herpes_UL6 PF01763.16 EEA27513.1 - 0.047 12.2 0.0 0.064 11.8 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like WD40 PF00400.32 EEA27514.1 - 1.3e-27 95.5 15.8 7.5e-06 26.6 0.1 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 EEA27514.1 - 4.3e-10 39.3 0.2 9.9e-10 38.2 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA27514.1 - 1e-05 25.3 0.1 2e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EEA27514.1 - 1.7e-05 25.0 0.2 1.1 9.6 0.0 4.4 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EEA27514.1 - 0.0009 18.9 0.0 0.081 12.5 0.0 2.2 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.21 EEA27514.1 - 0.014 15.3 1.3 18 5.5 0.0 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat F-box_4 PF15966.5 EEA27514.1 - 0.014 15.3 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 F-box ADH_N PF08240.12 EEA27515.1 - 1.3e-29 102.3 6.5 2.5e-29 101.3 6.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA27515.1 - 5.3e-16 58.8 0.1 1.7e-15 57.2 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA27515.1 - 0.00033 20.1 0.3 0.00061 19.2 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EEA27515.1 - 0.12 13.4 0.0 0.2 12.7 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DHDPS PF00701.22 EEA27516.1 - 4e-33 114.4 0.0 1.3e-24 86.5 0.0 2.0 2 0 0 2 2 2 2 Dihydrodipicolinate synthetase family GFO_IDH_MocA PF01408.22 EEA27517.1 - 1.2e-07 32.5 0.2 3.4e-07 31.1 0.2 1.9 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold LigB PF02900.18 EEA27517.1 - 0.003 16.7 0.1 0.0051 15.9 0.1 1.3 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Forkhead PF00250.18 EEA27518.1 - 7.4e-36 122.3 1.8 1.3e-35 121.5 1.8 1.4 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EEA27518.1 - 7.3e-08 32.7 0.0 1.6e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-C2H2 PF00096.26 EEA27519.1 - 2.2e-06 27.8 18.1 1.7e-05 25.0 2.0 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA27519.1 - 2.4e-05 24.5 5.6 3.7e-05 24.0 2.6 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EEA27519.1 - 0.00012 22.3 0.4 0.00044 20.4 0.4 2.1 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EEA27519.1 - 0.00013 22.5 1.4 0.00013 22.5 1.4 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EEA27519.1 - 0.0016 18.7 2.9 0.0046 17.2 2.9 1.9 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EEA27519.1 - 0.013 15.5 1.3 0.027 14.5 1.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger MRFAP1 PF15155.6 EEA27519.1 - 0.019 15.5 0.1 10 6.7 0.0 2.8 2 0 0 2 2 2 0 MORF4 family-associated protein1 zf-met PF12874.7 EEA27519.1 - 0.044 14.2 0.4 0.12 12.8 0.4 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type 2OG-FeII_Oxy_3 PF13640.6 EEA27520.1 - 1.4e-12 48.4 0.1 2.1e-12 47.8 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 EEA27521.1 - 4.4e-28 98.0 0.1 8.5e-28 97.1 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27521.1 - 2.8e-11 43.3 12.6 4.8e-11 42.6 12.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA27522.1 - 2.9e-06 26.4 0.0 5.5e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain RR_TM4-6 PF06459.12 EEA27522.1 - 0.17 11.7 6.6 0.3 10.9 6.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4699 PF15770.5 EEA27522.1 - 0.44 10.3 7.7 0.86 9.3 7.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4699) Ago_PAZ PF18309.1 EEA27522.1 - 0.44 11.2 2.4 31 5.3 0.2 2.7 3 0 0 3 3 3 0 Argonaute PAZ domain DUF4551 PF15087.6 EEA27522.1 - 0.79 8.5 4.7 1.2 7.9 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GREB1 PF15782.5 EEA27522.1 - 3.3 4.7 8.2 4.4 4.3 8.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PHD PF00628.29 EEA27523.1 - 3.5e-11 42.8 8.0 8.5e-11 41.6 8.0 1.7 1 0 0 1 1 1 1 PHD-finger APH PF01636.23 EEA27523.1 - 0.0067 16.4 0.1 0.1 12.5 0.1 2.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family ABC_tran_Xtn PF12848.7 EEA27523.1 - 0.054 13.5 2.6 0.19 11.8 2.6 1.9 1 0 0 1 1 1 0 ABC transporter CSM2 PF16834.5 EEA27524.1 - 0.0099 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Shu complex component Csm2, DNA-binding Pal1 PF08316.11 EEA27525.1 - 2.2e-43 148.3 2.0 7.5e-42 143.4 2.0 2.7 1 1 0 1 1 1 1 Pal1 cell morphology protein DUF3915 PF13054.6 EEA27525.1 - 2.2 8.3 9.4 0.89 9.6 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Med31 PF05669.12 EEA27526.1 - 7.1e-30 102.9 0.0 9.1e-30 102.5 0.0 1.1 1 0 0 1 1 1 1 SOH1 GTP_EFTU PF00009.27 EEA27528.1 - 2.7e-54 183.7 0.0 4.4e-54 183.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EEA27528.1 - 2.2e-41 140.7 0.0 5.5e-41 139.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EEA27528.1 - 4.4e-12 46.2 2.5 6.2e-12 45.7 1.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA27528.1 - 0.00016 21.7 0.2 0.0036 17.4 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FlpD PF02662.16 EEA27528.1 - 0.13 12.3 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit GTP_EFTU_D4 PF14578.6 EEA27528.1 - 0.26 11.2 2.1 0.29 11.1 0.6 1.9 2 0 0 2 2 2 0 Elongation factor Tu domain 4 TFIIS_C PF01096.18 EEA27529.1 - 4.5e-18 64.8 3.3 4.5e-18 64.8 3.3 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EEA27529.1 - 2.7e-06 27.1 3.1 2.1e-05 24.3 1.0 3.2 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit zf-DNA_Pol PF08996.10 EEA27529.1 - 0.00089 19.1 4.0 0.0057 16.4 0.5 2.0 1 1 1 2 2 2 1 DNA Polymerase alpha zinc finger Zn_Tnp_IS1595 PF12760.7 EEA27529.1 - 0.0013 18.7 5.0 0.011 15.7 1.2 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain IBR PF01485.21 EEA27529.1 - 0.0034 17.6 4.1 0.47 10.7 0.3 2.3 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain PhnA_Zn_Ribbon PF08274.12 EEA27529.1 - 0.014 15.3 5.4 0.096 12.7 0.2 3.1 3 0 0 3 3 3 0 PhnA Zinc-Ribbon C1_4 PF07975.12 EEA27529.1 - 0.023 14.9 4.4 0.14 12.4 0.2 2.5 2 1 0 2 2 2 0 TFIIH C1-like domain C1_1 PF00130.22 EEA27529.1 - 0.031 14.2 1.1 0.33 10.9 0.1 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_recom PF13408.6 EEA27529.1 - 0.037 14.5 0.4 0.31 11.6 0.1 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-DNL PF05180.12 EEA27529.1 - 0.038 13.9 1.0 0.33 10.9 0.2 2.6 2 1 0 2 2 2 0 DNL zinc finger zinc_ribbon_12 PF11331.8 EEA27529.1 - 0.042 13.7 1.9 0.71 9.7 0.7 2.6 2 0 0 2 2 2 0 Probable zinc-ribbon domain Zn_Tnp_IS1 PF03811.13 EEA27529.1 - 0.044 13.5 1.9 0.044 13.5 1.9 2.4 3 0 0 3 3 3 0 InsA N-terminal domain DiS_P_DiS PF06750.13 EEA27529.1 - 0.12 12.5 0.6 0.32 11.1 0.2 1.9 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain NOB1_Zn_bind PF08772.11 EEA27529.1 - 0.18 12.0 4.5 1.8 8.8 0.2 2.6 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-H2C2_2 PF13465.6 EEA27529.1 - 0.58 10.7 12.0 0.81 10.2 0.1 4.0 4 0 0 4 4 4 0 Zinc-finger double domain zinc_ribbon_4 PF13717.6 EEA27529.1 - 0.67 9.9 11.4 4 7.4 0.2 3.9 3 1 1 4 4 4 0 zinc-ribbon domain Lar_restr_allev PF14354.6 EEA27529.1 - 0.74 10.2 5.2 5.9 7.4 5.2 2.2 1 1 0 1 1 1 0 Restriction alleviation protein Lar Ank_3 PF13606.6 EEA27530.1 - 5.5e-08 32.5 0.0 0.017 15.6 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EEA27530.1 - 1.5e-07 31.6 0.2 0.026 14.8 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA27530.1 - 2.9e-07 31.0 0.0 5.6e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA27530.1 - 5.3e-06 26.6 0.0 0.036 14.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EEA27530.1 - 2.9e-05 24.5 0.2 0.0041 17.7 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) PPR_long PF17177.4 EEA27530.1 - 0.0016 17.8 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP TcdB_N PF12918.7 EEA27530.1 - 0.066 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain dsRBD2 PF17842.1 EEA27530.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.6 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 PALP PF00291.25 EEA27531.1 - 7.6e-50 170.0 3.0 1.2e-40 139.8 2.0 2.0 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme HisG_C PF08029.11 EEA27531.1 - 0.01 16.0 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 HisG, C-terminal domain ADH_zinc_N PF00107.26 EEA27531.1 - 0.073 13.0 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Bac_rhamnosid6H PF17389.2 EEA27532.1 - 3.8e-15 56.0 2.0 6e-13 48.7 1.0 2.2 2 0 0 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 EEA27532.1 - 9.7e-08 31.7 0.0 2.3e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid PF05592.11 EEA27532.1 - 0.0054 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Cadherin-like PF12733.7 EEA27532.1 - 0.016 15.7 0.5 0.079 13.5 0.1 2.4 2 1 0 2 2 2 0 Cadherin-like beta sandwich domain Glyco_hydro_28 PF00295.17 EEA27533.1 - 6e-44 150.4 3.9 2.9e-43 148.2 3.9 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 MAGE PF01454.19 EEA27534.1 - 2.3e-63 213.7 0.0 3.9e-63 213.0 0.0 1.4 1 0 0 1 1 1 1 MAGE family Chalcone_2 PF16035.5 EEA27535.1 - 6.6e-78 261.2 0.0 9.4e-78 260.7 0.0 1.2 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EEA27535.1 - 0.034 14.3 0.1 0.2 11.8 0.0 2.0 2 0 0 2 2 2 0 Chalcone isomerase-like Glutaredoxin PF00462.24 EEA27536.1 - 9.3e-20 70.6 0.0 1.4e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 EEA27536.1 - 0.0013 19.1 0.1 0.0021 18.5 0.1 1.5 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin PF00085.20 EEA27536.1 - 0.0022 18.0 0.0 0.0026 17.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EEA27536.1 - 0.0079 16.6 0.1 0.011 16.1 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 EEA27536.1 - 0.01 15.6 0.1 0.081 12.7 0.1 2.0 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 EEA27536.1 - 0.018 15.1 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain She2p PF11435.8 EEA27536.1 - 0.12 12.1 0.0 0.12 12.0 0.0 1.0 1 0 0 1 1 1 0 RNA binding protein She2p Thioredoxin_4 PF13462.6 EEA27536.1 - 0.2 11.8 1.1 5.2 7.2 0.3 2.1 1 1 0 2 2 2 0 Thioredoxin Glutaredoxin PF00462.24 EEA27537.1 - 9.3e-20 70.6 0.0 1.4e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 EEA27537.1 - 0.0013 19.1 0.1 0.0021 18.5 0.1 1.5 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin PF00085.20 EEA27537.1 - 0.0022 18.0 0.0 0.0026 17.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EEA27537.1 - 0.0079 16.6 0.1 0.011 16.1 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 EEA27537.1 - 0.01 15.6 0.1 0.081 12.7 0.1 2.0 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 EEA27537.1 - 0.018 15.1 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain She2p PF11435.8 EEA27537.1 - 0.12 12.1 0.0 0.12 12.0 0.0 1.0 1 0 0 1 1 1 0 RNA binding protein She2p Thioredoxin_4 PF13462.6 EEA27537.1 - 0.2 11.8 1.1 5.2 7.2 0.3 2.1 1 1 0 2 2 2 0 Thioredoxin BAG PF02179.16 EEA27539.1 - 8.2e-14 51.8 0.0 1.4e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 EEA27539.1 - 1.9e-06 27.5 0.0 3.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 EEA27539.1 - 0.07 13.5 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain LMBR1 PF04791.16 EEA27540.1 - 4e-125 418.6 1.3 4.6e-125 418.4 1.3 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Med15_fungi PF05397.12 EEA27541.1 - 1.3e-31 109.2 2.4 1.3e-31 109.2 2.4 4.9 5 0 0 5 5 5 2 Mediator complex subunit 15 KIX_2 PF16987.5 EEA27541.1 - 1.2e-09 38.0 0.2 1.2e-09 38.0 0.2 2.5 2 0 0 2 2 2 1 KIX domain KIX PF02172.16 EEA27541.1 - 0.08 13.2 0.8 0.24 11.7 0.3 2.0 2 0 0 2 2 2 0 KIX domain EamA PF00892.20 EEA27542.1 - 2.7e-11 43.8 24.4 7.5e-06 26.2 4.2 2.6 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EEA27542.1 - 1.1e-07 31.4 1.5 2.3e-07 30.3 1.5 1.6 1 1 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EEA27542.1 - 1.1e-05 24.8 5.9 1.1e-05 24.8 5.9 1.6 2 0 0 2 2 2 1 UAA transporter family TPT PF03151.16 EEA27542.1 - 2.6e-05 23.7 4.4 0.00019 20.9 0.2 2.4 2 0 0 2 2 2 2 Triose-phosphate Transporter family Trp_oprn_chp PF09534.10 EEA27542.1 - 0.049 13.4 1.2 0.43 10.3 0.7 2.3 1 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) MBOAT PF03062.19 EEA27543.1 - 1.8e-34 119.7 28.0 1.5e-33 116.6 28.0 2.0 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MLANA PF14991.6 EEA27543.1 - 0.37 11.1 1.7 0.78 10.0 0.0 2.3 3 0 0 3 3 3 0 Protein melan-A Adaptin_N PF01602.20 EEA27544.1 - 4e-143 477.8 1.1 4.7e-143 477.5 1.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EEA27544.1 - 2.2e-19 69.8 0.0 4.8e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EEA27544.1 - 7.6e-07 29.3 9.4 0.00025 21.1 0.1 4.5 3 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA27544.1 - 4.9e-05 23.6 3.1 0.65 10.4 0.0 4.6 5 1 0 5 5 5 2 HEAT repeats HEAT PF02985.22 EEA27544.1 - 0.06 13.6 2.0 20 5.8 0.1 4.6 3 0 0 3 3 3 0 HEAT repeat RICTOR_M PF14666.6 EEA27544.1 - 0.14 11.9 0.4 0.98 9.2 0.0 2.4 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain DnaJ PF00226.31 EEA27545.1 - 4.2e-20 71.6 0.2 1.1e-19 70.3 0.2 1.8 1 0 0 1 1 1 1 DnaJ domain Metallophos PF00149.28 EEA27546.1 - 8.9e-13 49.2 0.2 1.4e-12 48.5 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA27546.1 - 1.9e-05 24.9 0.0 0.00056 20.1 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AidB_N PF18158.1 EEA27546.1 - 0.032 14.2 0.0 0.051 13.5 0.0 1.2 1 0 0 1 1 1 0 Adaptive response protein AidB N-terminal domain Ribosomal_L13 PF00572.18 EEA27547.1 - 5.5e-11 42.8 0.1 6.6e-09 36.1 0.0 2.6 2 1 0 2 2 2 1 Ribosomal protein L13 AMP-binding PF00501.28 EEA27548.1 - 1.3e-71 241.4 0.0 1.5e-71 241.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA27548.1 - 1.9e-19 70.4 0.1 4e-19 69.4 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LysR_substrate PF03466.20 EEA27548.1 - 0.03 13.7 0.1 0.06 12.7 0.1 1.4 1 0 0 1 1 1 0 LysR substrate binding domain LRR_4 PF12799.7 EEA27549.1 - 4.7e-14 52.3 10.8 1.3 9.6 0.1 7.5 6 1 0 7 7 7 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EEA27549.1 - 1.8e-13 49.4 18.0 0.69 10.1 0.0 12.7 14 0 0 14 14 14 4 Leucine Rich repeat F-box-like PF12937.7 EEA27549.1 - 1.3e-12 47.3 1.2 2.2e-11 43.5 0.3 2.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EEA27549.1 - 8.8e-05 22.3 1.0 8.8e-05 22.3 1.0 3.2 3 0 0 3 3 3 1 F-box domain DUF1699 PF08004.11 EEA27549.1 - 0.0025 17.5 1.1 0.17 11.6 0.0 3.5 3 1 0 4 4 4 1 Protein of unknown function (DUF1699) Pox_F12L PF03337.13 EEA27549.1 - 0.11 10.7 0.2 0.89 7.6 0.0 2.0 2 0 0 2 2 2 0 Poxvirus F12L protein Preseq_ALAS PF09029.10 EEA27549.1 - 0.36 11.3 8.5 0.43 11.1 0.0 3.7 3 1 1 4 4 4 0 5-aminolevulinate synthase presequence LRR_8 PF13855.6 EEA27549.1 - 0.57 10.0 10.3 2.4 8.0 0.1 5.7 4 2 1 5 5 5 0 Leucine rich repeat LRR_4 PF12799.7 EEA27550.1 - 4.7e-14 52.3 10.8 1.3 9.6 0.1 7.5 6 1 0 7 7 7 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EEA27550.1 - 1.8e-13 49.4 18.0 0.69 10.1 0.0 12.7 14 0 0 14 14 14 4 Leucine Rich repeat F-box-like PF12937.7 EEA27550.1 - 1.3e-12 47.3 1.2 2.2e-11 43.5 0.3 2.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EEA27550.1 - 8.8e-05 22.3 1.0 8.8e-05 22.3 1.0 3.2 3 0 0 3 3 3 1 F-box domain DUF1699 PF08004.11 EEA27550.1 - 0.0025 17.5 1.1 0.17 11.6 0.0 3.5 3 1 0 4 4 4 1 Protein of unknown function (DUF1699) Pox_F12L PF03337.13 EEA27550.1 - 0.11 10.7 0.2 0.89 7.6 0.0 2.0 2 0 0 2 2 2 0 Poxvirus F12L protein Preseq_ALAS PF09029.10 EEA27550.1 - 0.36 11.3 8.5 0.43 11.1 0.0 3.7 3 1 1 4 4 4 0 5-aminolevulinate synthase presequence LRR_8 PF13855.6 EEA27550.1 - 0.57 10.0 10.3 2.4 8.0 0.1 5.7 4 2 1 5 5 5 0 Leucine rich repeat Peptidase_M28 PF04389.17 EEA27551.1 - 2.9e-34 118.5 0.0 4.4e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EEA27551.1 - 0.093 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Pro_CA PF00484.19 EEA27552.1 - 3.1e-12 47.0 1.5 4.5e-11 43.3 1.5 2.0 1 1 0 1 1 1 1 Carbonic anhydrase DUF1254 PF06863.12 EEA27552.1 - 0.15 12.1 0.1 11 6.1 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1254) p450 PF00067.22 EEA27553.1 - 9.8e-72 242.2 0.0 1.3e-71 241.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2840 PF11000.8 EEA27553.1 - 0.08 12.7 0.2 0.59 9.9 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2840) Med10 PF09748.9 EEA27556.1 - 1.9e-42 144.0 0.1 2.4e-42 143.7 0.1 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 EEA27556.1 - 0.037 13.9 0.0 0.039 13.8 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) Pkinase PF00069.25 EEA27557.1 - 3.9e-39 134.6 0.0 5.9e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27557.1 - 1.6e-27 96.4 0.0 2.4e-27 95.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA27557.1 - 0.002 17.5 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA27557.1 - 0.054 12.8 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LMBR1 PF04791.16 EEA27558.1 - 0.13 11.2 1.9 0.17 10.7 1.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Sugar_tr PF00083.24 EEA27560.1 - 2.2e-85 287.2 29.0 2.8e-85 286.9 29.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA27560.1 - 4.5e-15 55.4 36.5 4.1e-11 42.4 11.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SRPRB PF09439.10 EEA27560.1 - 0.013 15.0 0.2 0.02 14.3 0.2 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit HalX PF08663.10 EEA27560.1 - 0.35 11.2 1.3 0.64 10.4 1.3 1.3 1 0 0 1 1 1 0 HalX domain TPR_1 PF00515.28 EEA27561.1 - 1.3e-46 154.5 15.4 4.4e-08 32.6 0.3 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EEA27561.1 - 7.1e-43 141.3 15.3 1.7e-06 27.7 0.1 7.7 7 0 0 7 7 7 7 Tetratricopeptide repeat DnaJ PF00226.31 EEA27561.1 - 1.5e-24 85.9 3.4 1.5e-24 85.9 3.4 3.3 4 0 0 4 4 2 1 DnaJ domain TPR_11 PF13414.6 EEA27561.1 - 1.7e-24 85.2 17.8 5.6e-10 38.7 0.5 7.1 4 2 2 6 6 6 6 TPR repeat TPR_8 PF13181.6 EEA27561.1 - 2.7e-24 83.3 10.2 0.00016 21.6 0.2 7.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 EEA27561.1 - 1e-23 83.7 14.2 2.8e-05 24.6 0.1 5.4 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 EEA27561.1 - 1.9e-22 79.6 22.2 6.1e-06 26.7 0.2 5.8 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EEA27561.1 - 2.6e-21 74.5 15.2 0.00014 22.4 0.2 8.0 3 2 4 7 7 7 7 Tetratricopeptide repeat TPR_17 PF13431.6 EEA27561.1 - 4.1e-21 73.8 15.0 4.7e-05 23.5 0.0 7.8 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EEA27561.1 - 1.2e-16 60.8 15.8 0.00019 21.7 1.1 6.2 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EEA27561.1 - 1.9e-16 58.8 10.9 0.13 12.4 0.3 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA27561.1 - 1.6e-13 50.6 9.3 0.00023 21.3 0.0 4.9 2 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EEA27561.1 - 5.8e-13 48.7 9.7 0.00024 21.1 0.1 5.4 4 1 1 5 5 5 4 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EEA27561.1 - 1.8e-10 40.8 18.1 0.018 15.6 0.3 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 EEA27561.1 - 2.3e-10 40.1 9.3 0.003 16.8 0.2 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_9 PF13371.6 EEA27561.1 - 1.8e-09 37.6 10.9 0.096 12.9 1.3 5.2 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 EEA27561.1 - 3.6e-06 26.6 19.9 1.6 8.7 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat BTAD PF03704.17 EEA27561.1 - 8.8e-06 26.2 8.2 0.031 14.7 0.0 4.6 3 1 0 4 4 4 2 Bacterial transcriptional activator domain SHNi-TPR PF10516.9 EEA27561.1 - 0.00052 19.4 8.6 2.1 7.9 0.5 5.2 5 0 0 5 5 5 1 SHNi-TPR ChAPs PF09295.10 EEA27561.1 - 0.00068 18.8 2.1 0.1 11.6 0.1 3.0 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) Alkyl_sulf_dimr PF14863.6 EEA27561.1 - 0.0011 19.5 6.6 15 6.0 0.6 4.9 2 2 2 4 4 4 0 Alkyl sulfatase dimerisation TPR_20 PF14561.6 EEA27561.1 - 0.0011 19.2 11.2 0.68 10.3 0.2 4.2 3 1 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 EEA27561.1 - 0.011 15.8 14.6 1.6 8.8 0.1 5.1 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain DUF627 PF04781.12 EEA27561.1 - 0.077 13.0 1.4 0.53 10.3 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF627) TPR_4 PF07721.14 EEA27561.1 - 0.1 13.3 17.6 0.54 11.0 0.4 5.8 7 0 0 7 7 5 0 Tetratricopeptide repeat RPT PF13446.6 EEA27561.1 - 1.4 8.9 4.7 2.5 8.1 0.1 3.6 4 0 0 4 4 3 0 A repeated domain in UCH-protein DUF4451 PF14616.6 EEA27562.1 - 6.3e-25 87.7 0.1 1.2e-24 86.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) IL11 PF07400.11 EEA27562.1 - 1.4 8.6 6.1 4.7 6.8 0.4 2.2 2 0 0 2 2 2 0 Interleukin 11 TFIIA PF03153.13 EEA27563.1 - 0.00037 20.6 3.2 0.00037 20.6 3.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 EEA27563.1 - 0.003 17.6 0.8 0.0033 17.4 0.8 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DUF2722 PF10846.8 EEA27563.1 - 0.0077 15.2 9.2 0.011 14.8 9.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TERB2 PF15101.6 EEA27563.1 - 0.0085 16.2 4.4 0.013 15.6 4.4 1.2 1 0 0 1 1 1 1 Telomere-associated protein TERB2 GNAT_acetyltr_2 PF13718.6 EEA27563.1 - 0.024 14.1 0.7 0.034 13.5 0.7 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Presenilin PF01080.17 EEA27563.1 - 0.058 12.2 0.2 0.058 12.1 0.2 1.1 1 0 0 1 1 1 0 Presenilin TMEM208_SND2 PF05620.11 EEA27563.1 - 0.24 11.2 1.4 0.34 10.7 1.4 1.2 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF4834 PF16118.5 EEA27563.1 - 0.9 10.5 5.9 1.4 9.9 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CCDC53 PF10152.9 EEA27563.1 - 1.9 8.9 9.2 5.9 7.3 9.2 1.7 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex Spt20 PF12090.8 EEA27563.1 - 4.9 6.7 21.2 7 6.2 21.2 1.1 1 0 0 1 1 1 0 Spt20 family Activator_LAG-3 PF11498.8 EEA27563.1 - 9.6 5.0 22.9 13 4.6 22.9 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Med15 PF09606.10 EEA27564.1 - 0.0015 17.4 15.0 0.002 16.9 15.0 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 EEA27564.1 - 0.0029 16.6 8.5 0.0038 16.2 8.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Suf PF05843.14 EEA27564.1 - 0.004 17.2 0.8 0.0052 16.8 0.8 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) TERB2 PF15101.6 EEA27564.1 - 0.011 15.8 4.4 0.017 15.2 4.4 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 GNAT_acetyltr_2 PF13718.6 EEA27564.1 - 0.032 13.6 0.7 0.047 13.1 0.7 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Presenilin PF01080.17 EEA27564.1 - 0.064 12.0 0.2 0.057 12.2 0.2 1.1 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 EEA27564.1 - 0.21 10.0 0.1 0.25 9.8 0.1 1.0 1 0 0 1 1 1 0 FHIPEP family TMEM208_SND2 PF05620.11 EEA27564.1 - 0.3 10.9 1.4 0.45 10.3 1.4 1.2 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF4834 PF16118.5 EEA27564.1 - 1.1 10.3 5.9 1.9 9.5 5.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Pkinase PF00069.25 EEA27566.1 - 9.3e-66 221.9 0.0 1.1e-65 221.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27566.1 - 9.9e-37 126.6 0.0 1.5e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA27566.1 - 2e-07 30.6 0.0 3.4e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA27566.1 - 7.8e-05 21.6 0.0 0.00012 21.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EEA27566.1 - 0.016 14.9 0.0 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EEA27566.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EEA27566.1 - 0.14 11.1 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Sec39 PF08314.11 EEA27567.1 - 8.5e-259 861.0 2.9 1e-258 860.8 2.9 1.1 1 0 0 1 1 1 1 Secretory pathway protein Sec39 DUF2721 PF11026.8 EEA27567.1 - 0.11 12.4 0.1 2.9 7.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Ndufs5 PF10200.9 EEA27568.1 - 1.3e-05 25.4 0.1 1.7e-05 25.0 0.1 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa COX6B PF02297.17 EEA27568.1 - 0.077 13.2 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb DUF3128 PF11326.8 EEA27568.1 - 0.16 12.4 0.8 0.9 10.0 0.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) DUF3535 PF12054.8 EEA27569.1 - 1.2e-128 430.1 0.0 2.1e-127 426.0 0.0 2.9 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EEA27569.1 - 1.8e-62 211.1 0.0 3.7e-62 210.1 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA27569.1 - 1.5e-19 70.4 0.0 4.1e-19 68.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 EEA27569.1 - 9e-14 50.4 18.0 0.27 11.6 0.0 10.6 11 0 0 11 11 9 4 HEAT repeat HEAT_2 PF13646.6 EEA27569.1 - 8.2e-09 35.7 13.0 0.0027 18.1 0.2 6.8 5 1 1 6 6 6 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EEA27569.1 - 5.1e-07 30.2 0.3 0.014 16.0 0.1 3.9 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EEA27569.1 - 4.4e-05 23.6 0.5 0.053 13.6 0.1 4.7 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 EEA27569.1 - 0.00067 19.9 0.6 0.74 10.2 0.0 5.3 6 0 0 6 6 6 1 TAF6 C-terminal HEAT repeat domain CLASP_N PF12348.8 EEA27569.1 - 0.0098 15.5 0.3 1.6 8.3 0.0 3.4 2 1 1 3 3 3 1 CLASP N terminal ERCC3_RAD25_C PF16203.5 EEA27569.1 - 0.066 12.4 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase HEAT_EZ PF13513.6 EEA27569.1 - 0.47 11.0 18.7 9.2 6.9 0.0 7.7 9 0 0 9 9 9 0 HEAT-like repeat Erythro_esteras PF05139.14 EEA27571.1 - 1.8e-126 422.7 2.2 2e-126 422.4 2.2 1.0 1 0 0 1 1 1 1 Erythromycin esterase Cofac_haem_bdg PF04187.13 EEA27571.1 - 0.0022 18.0 0.1 0.46 10.4 0.0 2.2 2 0 0 2 2 2 2 Haem-binding uptake, Tiki superfamily, ChaN Acetyltransf_3 PF13302.7 EEA27571.1 - 0.14 12.8 0.9 34 5.1 0.1 2.9 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain Nop52 PF05997.12 EEA27572.1 - 0.12 12.1 0.0 1.8 8.3 0.1 2.2 2 0 0 2 2 2 0 Nucleolar protein,Nop52 Scs3p PF10261.9 EEA27573.1 - 3.8e-69 232.9 1.8 8.6e-69 231.8 1.8 1.6 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Fungal_trans PF04082.18 EEA27573.1 - 3.3e-18 65.7 1.0 3.3e-18 65.7 1.0 2.1 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27573.1 - 1.6e-07 31.3 8.1 2.9e-07 30.5 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_3_C PF01915.22 EEA27574.1 - 1.7e-54 184.9 0.0 3.4e-54 183.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA27574.1 - 4.1e-40 138.1 0.0 6.6e-40 137.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA27574.1 - 1.7e-13 50.4 0.2 3.2e-13 49.6 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain MFS_1 PF07690.16 EEA27575.1 - 4.7e-31 108.0 43.9 2.9e-27 95.5 23.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA27575.1 - 2.8e-22 79.2 18.6 3.5e-22 78.9 18.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Spore_YtrH PF14034.6 EEA27575.1 - 0.037 14.2 5.2 0.46 10.7 0.4 2.8 2 1 0 2 2 2 0 Sporulation protein YtrH bZIP_1 PF00170.21 EEA27576.1 - 0.0006 19.9 16.2 0.00074 19.6 10.8 2.3 1 1 1 2 2 2 1 bZIP transcription factor ChapFlgA_N PF17656.1 EEA27576.1 - 0.033 14.4 0.4 0.26 11.5 0.0 2.4 2 0 0 2 2 2 0 FlgA N-terminal domain DUF773 PF05600.12 EEA27576.1 - 0.31 9.7 5.6 0.11 11.2 3.3 1.4 2 0 0 2 2 2 0 CDK5 regulatory subunit-associated protein 3 ABC_tran_Xtn PF12848.7 EEA27576.1 - 0.53 10.3 11.2 0.96 9.5 11.2 1.4 1 0 0 1 1 1 0 ABC transporter EBP PF05241.12 EEA27577.1 - 0.23 10.9 8.5 0.18 11.2 3.5 2.4 2 1 0 3 3 3 0 Emopamil binding protein TraD_N PF12615.8 EEA27577.1 - 0.39 11.5 3.8 0.29 11.9 0.5 2.3 2 1 0 2 2 2 0 F sex factor protein N terminal adh_short PF00106.25 EEA27578.1 - 2e-30 105.7 0.0 6.8e-30 104.0 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA27578.1 - 2.5e-19 69.8 0.0 3.5e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA27578.1 - 1e-11 45.1 0.0 1.5e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EEA27578.1 - 0.00097 18.6 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EEA27578.1 - 0.0054 15.9 0.0 0.0082 15.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Fungal_trans PF04082.18 EEA27579.1 - 3.3e-23 82.1 0.0 6.2e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27579.1 - 1.6e-09 37.8 12.5 2.5e-09 37.1 12.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATG27 PF09451.10 EEA27580.1 - 2.4e-13 50.6 0.1 1.1e-12 48.4 0.1 1.9 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EEA27580.1 - 4.7e-12 45.6 0.0 1.2e-11 44.2 0.0 1.5 2 0 0 2 2 2 1 Mannose-6-phosphate receptor CIMR PF00878.18 EEA27580.1 - 1.7e-09 37.9 0.8 0.00019 21.5 0.2 2.5 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat DUF3430 PF11912.8 EEA27580.1 - 0.17 11.9 0.8 0.33 11.0 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3430) ERG4_ERG24 PF01222.17 EEA27581.1 - 1.3e-155 518.4 4.6 1.5e-155 518.2 4.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EEA27581.1 - 0.00013 21.6 0.6 0.0004 20.0 0.6 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) NT-C2 PF10358.9 EEA27582.1 - 2.4e-37 127.9 0.0 3.5e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins JLPA PF16668.5 EEA27582.1 - 0.069 12.2 0.0 0.093 11.8 0.0 1.1 1 0 0 1 1 1 0 Adhesin from Campylobacter FliJ PF02050.16 EEA27583.1 - 0.0018 18.5 3.5 0.0024 18.1 3.5 1.1 1 0 0 1 1 1 1 Flagellar FliJ protein Seryl_tRNA_N PF02403.22 EEA27583.1 - 0.0091 16.2 4.7 0.012 15.9 4.7 1.1 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain TPD52 PF04201.15 EEA27583.1 - 0.015 14.9 0.5 0.019 14.6 0.5 1.2 1 0 0 1 1 1 0 Tumour protein D52 family RNA_pol_Rpb1_2 PF00623.20 EEA27583.1 - 0.023 14.9 0.6 0.027 14.7 0.6 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 2 Ku_C PF03730.14 EEA27583.1 - 0.064 14.0 2.7 0.097 13.4 2.7 1.3 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm NPV_P10 PF05531.12 EEA27583.1 - 0.071 13.6 0.8 0.17 12.3 0.8 1.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Uso1_p115_C PF04871.13 EEA27583.1 - 0.18 12.2 8.2 0.24 11.8 8.2 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region PRKCSH-like PF12999.7 EEA27583.1 - 0.29 10.9 2.4 0.37 10.6 2.4 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like TMPIT PF07851.13 EEA27583.1 - 2.1 7.5 4.7 2.6 7.2 4.7 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF4337 PF14235.6 EEA27583.1 - 3.2 7.8 7.1 4.1 7.5 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Ribosomal_L27_C PF18471.1 EEA27584.1 - 0.02 14.3 6.6 1.7 8.0 0.6 3.9 3 1 0 3 3 3 0 Ribosomal L27 protein C-terminal domain Cnd1 PF12717.7 EEA27584.1 - 0.14 12.1 1.9 9.3 6.3 0.5 2.8 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 E3_UbLigase_R4 PF13764.6 EEA27584.1 - 0.68 8.0 2.7 0.62 8.2 1.5 1.4 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase UBR4 Sugar_tr PF00083.24 EEA27585.1 - 2.5e-99 333.2 29.4 3e-99 332.9 29.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA27585.1 - 1e-24 87.1 42.7 2.2e-19 69.6 15.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Putative_PNPOx PF01243.20 EEA27586.1 - 1.9e-06 28.0 0.0 4.2e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF5113 PF17140.4 EEA27587.1 - 0.16 11.8 0.1 0.21 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) DUF3074 PF11274.8 EEA27589.1 - 4.8e-56 189.7 0.5 3e-55 187.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) START PF01852.19 EEA27589.1 - 0.0039 16.6 0.0 0.42 10.0 0.0 2.4 2 0 0 2 2 2 1 START domain APG6_N PF17675.1 EEA27589.1 - 0.017 15.7 28.4 0.02 15.4 6.1 3.6 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF812 PF05667.11 EEA27589.1 - 0.023 13.6 15.7 0.043 12.7 15.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF812) HALZ PF02183.18 EEA27589.1 - 0.026 14.7 0.7 0.026 14.7 0.7 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Fez1 PF06818.15 EEA27589.1 - 0.1 13.0 19.7 0.32 11.4 19.7 1.8 1 0 0 1 1 1 0 Fez1 Uds1 PF15456.6 EEA27589.1 - 1.5 9.0 20.6 4.7 7.4 0.9 3.1 2 1 0 2 2 2 0 Up-regulated During Septation DUF4776 PF16003.5 EEA27589.1 - 1.6 7.7 14.1 2.7 6.9 14.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SKA2 PF16740.5 EEA27589.1 - 5.1 6.9 9.1 0.78 9.5 2.2 2.8 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 ATG16 PF08614.11 EEA27589.1 - 8.2 6.6 31.6 4.4 7.5 20.2 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SF3b10 PF07189.11 EEA27590.1 - 3.1e-35 120.1 0.0 3.4e-35 120.0 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) SLS PF14611.6 EEA27591.1 - 5.9e-27 94.9 0.0 1.1e-26 94.0 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator A_deamin PF02137.18 EEA27591.1 - 4e-18 65.9 0.0 3.2e-16 59.7 0.0 2.5 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain Stathmin PF00836.19 EEA27592.1 - 0.00082 19.3 0.7 0.0013 18.7 0.7 1.3 1 0 0 1 1 1 1 Stathmin family DUF3584 PF12128.8 EEA27592.1 - 0.0033 15.0 2.6 0.0041 14.7 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF5344 PF17279.2 EEA27592.1 - 0.01 16.4 0.8 0.34 11.5 0.6 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Noelin-1 PF12308.8 EEA27592.1 - 0.017 15.1 4.7 1.5 8.8 2.2 2.9 1 1 1 2 2 2 0 Neurogenesis glycoprotein OmpH PF03938.14 EEA27592.1 - 0.13 12.6 1.3 0.22 11.9 1.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MeaB PF03308.16 EEA27592.1 - 0.3 10.0 1.0 0.41 9.6 1.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLZ PF16526.5 EEA27592.1 - 1 9.7 7.7 14 6.1 0.2 3.0 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_DNA_bd PF12329.8 EEA27592.1 - 1.3 9.1 5.6 1.1 9.3 0.5 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ABC_tran_CTD PF16326.5 EEA27592.1 - 1.3 9.4 5.2 12 6.2 0.4 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain zf-C4H2 PF10146.9 EEA27592.1 - 2.2 8.5 10.5 0.42 10.9 6.9 1.7 1 1 1 2 2 2 0 Zinc finger-containing protein Rotamase_3 PF13616.6 EEA27593.1 - 1.4e-15 57.8 0.1 2.8e-15 56.9 0.1 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EEA27593.1 - 1.7e-13 51.3 0.0 3.1e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EEA27593.1 - 0.0081 17.0 0.0 0.012 16.4 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain 2OG-FeII_Oxy_2 PF13532.6 EEA27594.1 - 3.1e-12 47.1 0.0 1.1e-10 42.1 0.0 2.0 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily Steroid_dh PF02544.16 EEA27595.1 - 6.4e-11 42.4 0.3 6.4e-11 42.4 0.3 2.2 3 0 0 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF4227 PF14004.6 EEA27595.1 - 0.056 13.4 0.2 0.18 11.8 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) Ank_2 PF12796.7 EEA27596.1 - 2.7e-21 75.9 0.5 2.2e-11 44.2 0.1 3.9 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA27596.1 - 3e-19 68.8 1.8 5.8e-07 29.7 0.0 5.4 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA27596.1 - 1.9e-15 57.0 0.1 1.1e-07 32.2 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA27596.1 - 5.3e-13 48.8 1.9 0.0027 18.1 0.1 5.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 EEA27596.1 - 1e-10 40.9 2.7 0.035 14.6 0.0 5.3 6 0 0 6 6 6 3 Ankyrin repeat DDE_1 PF03184.19 EEA27597.1 - 1.2e-33 116.3 0.0 2.2e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA27597.1 - 2.6e-10 40.2 0.4 1.7e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA27597.1 - 2e-06 27.4 0.0 5.3e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-CCHC_2 PF13696.6 EEA27597.1 - 0.079 12.8 1.5 0.14 12.0 1.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EEA27597.1 - 0.34 11.1 2.1 0.62 10.3 2.1 1.5 1 0 0 1 1 1 0 Zinc knuckle Ribosomal_L7Ae PF01248.26 EEA27598.1 - 4.3e-27 93.7 0.9 5.5e-27 93.3 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EEA27598.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain DUF1846 PF08903.11 EEA27598.1 - 0.17 10.4 0.0 0.22 10.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) Vac_ImportDeg PF09783.9 EEA27599.1 - 2.2e-41 141.4 0.0 6.6e-41 139.8 0.0 1.8 2 0 0 2 2 2 1 Vacuolar import and degradation protein Atrophin-1 PF03154.15 EEA27599.1 - 0.0036 15.7 11.3 0.0064 14.8 11.3 1.4 1 0 0 1 1 1 1 Atrophin-1 family Vac_ImportDeg PF09783.9 EEA27600.1 - 2e-41 141.5 0.0 6e-41 139.9 0.0 1.8 2 0 0 2 2 2 1 Vacuolar import and degradation protein Atrophin-1 PF03154.15 EEA27600.1 - 0.0035 15.7 11.3 0.006 14.9 11.3 1.3 1 0 0 1 1 1 1 Atrophin-1 family IU_nuc_hydro PF01156.19 EEA27601.1 - 4.2e-84 282.7 0.0 4.9e-84 282.5 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PXA PF02194.15 EEA27602.1 - 2e-44 151.8 0.5 2.7e-44 151.3 0.5 1.2 1 0 0 1 1 1 1 PXA domain Presenilin PF01080.17 EEA27603.1 - 0.089 11.5 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Presenilin HTH_Tnp_Tc5 PF03221.16 EEA27604.1 - 9.6e-15 54.4 0.1 1.8e-14 53.5 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EEA27604.1 - 6.4e-06 25.7 0.1 1.3e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.6 EEA27604.1 - 0.00056 19.6 0.1 0.00099 18.8 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_4 PF13613.6 EEA27604.1 - 0.041 13.6 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease MarR PF01047.22 EEA27604.1 - 0.046 13.6 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_Crp_2 PF13545.6 EEA27604.1 - 0.13 12.2 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_10 PF04967.12 EEA27604.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 HTH DNA binding domain MMR_HSR1_Xtn PF16897.5 EEA27605.1 - 6.1e-40 135.5 1.4 1.7e-39 134.1 0.3 2.2 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EEA27605.1 - 2.5e-22 78.7 0.1 6.3e-22 77.4 0.1 1.8 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EEA27605.1 - 2.2e-21 76.1 0.1 6.5e-21 74.5 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA27605.1 - 1.1e-09 38.0 0.1 4.4e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA27605.1 - 0.00033 20.8 0.1 0.073 13.1 0.0 2.4 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 EEA27605.1 - 0.00067 19.3 0.1 6.5 6.2 0.0 3.9 2 2 1 3 3 3 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 EEA27605.1 - 0.0081 15.2 0.1 0.019 13.9 0.1 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EEA27605.1 - 0.021 14.1 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 AIG1 family Arf PF00025.21 EEA27605.1 - 0.1 12.0 0.1 3 7.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EEA27605.1 - 0.3 11.0 1.7 4.5 7.2 0.0 2.8 4 0 0 4 4 4 0 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EEA27606.1 - 6.9e-40 135.3 1.4 1.6e-39 134.2 0.3 2.0 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EEA27606.1 - 2.3e-22 78.8 0.1 5.9e-22 77.5 0.1 1.7 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EEA27606.1 - 2.3e-21 76.0 0.1 6.1e-21 74.6 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA27606.1 - 1e-09 38.1 0.1 4.1e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA27606.1 - 0.00034 20.7 0.1 0.066 13.3 0.0 2.3 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 EEA27606.1 - 0.00067 19.2 0.1 6.2 6.3 0.0 3.8 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 EEA27606.1 - 0.0079 15.2 0.1 0.018 14.0 0.1 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EEA27606.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 AIG1 family Arf PF00025.21 EEA27606.1 - 0.095 12.1 0.2 2.9 7.3 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EEA27606.1 - 0.15 11.9 0.4 4.2 7.2 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase CDO_I PF05995.12 EEA27607.1 - 1.2e-43 148.4 0.0 1.3e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EEA27607.1 - 0.015 14.8 0.1 0.029 13.8 0.1 1.5 1 1 0 1 1 1 0 PCO_ADO CDO_I PF05995.12 EEA27608.1 - 2.8e-39 134.2 0.0 3.5e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EEA27608.1 - 0.037 13.5 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 PCO_ADO CDO_I PF05995.12 EEA27609.1 - 2.6e-32 111.5 0.0 3.2e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EEA27609.1 - 0.03 13.8 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 PCO_ADO Glyco_transf_8 PF01501.20 EEA27610.1 - 3.7e-24 85.7 0.0 4.2e-23 82.2 0.0 2.4 2 1 0 2 2 2 1 Glycosyl transferase family 8 Prok-E2_E PF14462.6 EEA27610.1 - 0.023 14.5 1.2 0.31 10.8 0.0 2.4 2 0 0 2 2 2 0 Prokaryotic E2 family E Nucleotid_trans PF03407.16 EEA27610.1 - 0.025 14.5 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Glyco_transf_8 PF01501.20 EEA27611.1 - 3.9e-24 85.6 0.0 4.3e-23 82.2 0.0 2.4 2 1 0 2 2 2 1 Glycosyl transferase family 8 Prok-E2_E PF14462.6 EEA27611.1 - 0.024 14.4 1.2 0.32 10.8 0.0 2.4 2 0 0 2 2 2 0 Prokaryotic E2 family E Nucleotid_trans PF03407.16 EEA27611.1 - 0.026 14.5 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Abhydrolase_1 PF00561.20 EEA27612.1 - 2.9e-12 46.8 0.0 6.6e-10 39.1 0.0 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA27612.1 - 1e-10 42.6 0.1 5.2e-10 40.3 0.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA27612.1 - 9.6e-07 28.3 0.0 2.6e-06 26.9 0.0 1.7 3 0 0 3 3 3 1 Serine aminopeptidase, S33 ABC_cobalt PF09819.9 EEA27612.1 - 0.0069 16.5 0.9 0.22 11.6 0.1 2.3 2 0 0 2 2 2 1 ABC-type cobalt transport system, permease component EHN PF06441.12 EEA27612.1 - 0.03 14.7 0.3 0.068 13.5 0.3 1.6 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Ser_hydrolase PF06821.13 EEA27612.1 - 0.099 12.5 0.0 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_1 PF00561.20 EEA27613.1 - 2.9e-12 46.8 0.0 6.6e-10 39.1 0.0 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA27613.1 - 1e-10 42.6 0.1 5.2e-10 40.3 0.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA27613.1 - 9.6e-07 28.3 0.0 2.6e-06 26.9 0.0 1.7 3 0 0 3 3 3 1 Serine aminopeptidase, S33 ABC_cobalt PF09819.9 EEA27613.1 - 0.0069 16.5 0.9 0.22 11.6 0.1 2.3 2 0 0 2 2 2 1 ABC-type cobalt transport system, permease component EHN PF06441.12 EEA27613.1 - 0.03 14.7 0.3 0.068 13.5 0.3 1.6 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Ser_hydrolase PF06821.13 EEA27613.1 - 0.099 12.5 0.0 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_1 PF00561.20 EEA27614.1 - 2.9e-12 46.8 0.0 6.6e-10 39.1 0.0 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA27614.1 - 1e-10 42.6 0.1 5.2e-10 40.3 0.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA27614.1 - 9.6e-07 28.3 0.0 2.6e-06 26.9 0.0 1.7 3 0 0 3 3 3 1 Serine aminopeptidase, S33 ABC_cobalt PF09819.9 EEA27614.1 - 0.0069 16.5 0.9 0.22 11.6 0.1 2.3 2 0 0 2 2 2 1 ABC-type cobalt transport system, permease component EHN PF06441.12 EEA27614.1 - 0.03 14.7 0.3 0.068 13.5 0.3 1.6 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Ser_hydrolase PF06821.13 EEA27614.1 - 0.099 12.5 0.0 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Glyco_transf_90 PF05686.12 EEA27615.1 - 3.4e-18 65.7 3.9 7.5e-15 54.7 2.8 2.6 2 1 0 2 2 2 2 Glycosyl transferase family 90 Ferric_reduct PF01794.19 EEA27616.1 - 2.6e-13 50.2 5.0 2.6e-13 50.2 5.0 2.1 2 1 0 2 2 2 1 Ferric reductase like transmembrane component DUF1641 PF07849.11 EEA27616.1 - 0.026 14.4 0.0 0.07 13.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) DUF2104 PF09877.9 EEA27616.1 - 0.037 14.3 0.1 0.11 12.8 0.1 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2104) HEAT PF02985.22 EEA27617.1 - 2.6e-41 136.1 12.5 0.015 15.5 0.1 13.3 13 0 0 13 13 13 11 HEAT repeat HEAT_2 PF13646.6 EEA27617.1 - 2e-37 127.4 4.8 9.3e-11 42.0 0.0 8.4 3 3 4 8 8 8 7 HEAT repeats HEAT_EZ PF13513.6 EEA27617.1 - 5.1e-16 58.8 4.4 0.0097 16.4 0.0 8.2 8 2 2 10 10 9 4 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EEA27617.1 - 2.7e-13 50.3 3.9 0.00079 20.0 0.1 7.7 5 2 5 10 10 10 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EEA27617.1 - 2.3e-10 40.8 11.9 0.0028 17.7 0.1 6.0 4 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EEA27617.1 - 6.8e-09 34.8 5.9 0.0002 20.1 0.2 3.8 2 1 1 4 4 4 2 Adaptin N terminal region RTP1_C1 PF10363.9 EEA27617.1 - 3.7e-07 30.3 5.7 0.091 12.9 0.2 5.0 4 1 1 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EEA27617.1 - 0.0024 17.5 2.2 0.72 9.4 0.1 4.6 3 2 1 5 5 5 1 CLASP N terminal Proteasom_PSMB PF10508.9 EEA27617.1 - 0.011 14.2 5.4 0.42 9.0 0.0 2.9 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit Arm PF00514.23 EEA27617.1 - 0.017 15.2 7.9 3.1 8.0 0.0 5.8 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 EEA27617.1 - 0.038 13.1 0.9 1.7 7.7 0.0 3.6 3 1 1 4 4 4 0 Interferon-related developmental regulator (IFRD) M11L PF11099.8 EEA27617.1 - 0.063 13.6 0.8 34 4.7 0.0 3.7 2 1 1 3 3 3 0 Apoptosis regulator M11L like Ecm29 PF13001.7 EEA27617.1 - 0.085 11.5 3.5 2.5 6.7 0.2 3.5 3 1 0 4 4 4 0 Proteasome stabiliser DRIM PF07539.12 EEA27617.1 - 2 6.6 6.3 2.4 6.3 0.5 3.1 2 1 1 4 4 4 0 Down-regulated in metastasis HEAT PF02985.22 EEA27618.1 - 2.6e-41 136.1 12.5 0.015 15.5 0.1 13.3 13 0 0 13 13 13 11 HEAT repeat HEAT_2 PF13646.6 EEA27618.1 - 2e-37 127.4 4.8 9.3e-11 42.0 0.0 8.4 3 3 4 8 8 8 7 HEAT repeats HEAT_EZ PF13513.6 EEA27618.1 - 5.1e-16 58.8 4.4 0.0097 16.4 0.0 8.2 8 2 2 10 10 9 4 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EEA27618.1 - 2.7e-13 50.3 3.9 0.00079 20.0 0.1 7.7 5 2 5 10 10 10 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EEA27618.1 - 2.3e-10 40.8 11.9 0.0028 17.7 0.1 6.0 4 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EEA27618.1 - 6.8e-09 34.8 5.9 0.0002 20.1 0.2 3.8 2 1 1 4 4 4 2 Adaptin N terminal region RTP1_C1 PF10363.9 EEA27618.1 - 3.7e-07 30.3 5.7 0.091 12.9 0.2 5.0 4 1 1 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EEA27618.1 - 0.0024 17.5 2.2 0.72 9.4 0.1 4.6 3 2 1 5 5 5 1 CLASP N terminal Proteasom_PSMB PF10508.9 EEA27618.1 - 0.011 14.2 5.4 0.42 9.0 0.0 2.9 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit Arm PF00514.23 EEA27618.1 - 0.017 15.2 7.9 3.1 8.0 0.0 5.8 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 EEA27618.1 - 0.038 13.1 0.9 1.7 7.7 0.0 3.6 3 1 1 4 4 4 0 Interferon-related developmental regulator (IFRD) M11L PF11099.8 EEA27618.1 - 0.063 13.6 0.8 34 4.7 0.0 3.7 2 1 1 3 3 3 0 Apoptosis regulator M11L like Ecm29 PF13001.7 EEA27618.1 - 0.085 11.5 3.5 2.5 6.7 0.2 3.5 3 1 0 4 4 4 0 Proteasome stabiliser DRIM PF07539.12 EEA27618.1 - 2 6.6 6.3 2.4 6.3 0.5 3.1 2 1 1 4 4 4 0 Down-regulated in metastasis tRNA_synthFbeta PF17759.1 EEA27619.1 - 7.5e-49 166.1 0.0 1.1e-48 165.5 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EEA27619.1 - 1.5e-32 111.6 0.4 6.3e-31 106.4 0.1 2.5 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EEA27619.1 - 1.2e-23 83.7 0.0 2.7e-23 82.5 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EEA27619.1 - 2.4e-18 66.2 0.0 1.8e-15 57.0 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain Herpes_V23 PF01802.17 EEA27619.1 - 0.04 13.3 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein DUF2740 PF10872.8 EEA27619.1 - 0.059 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) Ribosomal_S3_C PF00189.20 EEA27620.1 - 9.6e-25 86.9 0.2 5.1e-24 84.6 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EEA27620.1 - 6.6e-12 45.1 0.1 1.2e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 EEA27620.1 - 0.1 13.1 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 EEA27620.1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Coilin N-terminus Myotub-related PF06602.14 EEA27621.1 - 5.4e-154 512.4 0.0 6.6e-154 512.1 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Cellulase PF00150.18 EEA27622.1 - 1.6e-15 57.3 0.3 2.3e-15 56.8 0.3 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) GlgX_C PF18390.1 EEA27622.1 - 0.0021 17.8 0.1 0.0054 16.5 0.1 1.6 1 0 0 1 1 1 1 Glycogen debranching enzyme C-terminal domain DBD_Tnp_Mut PF03108.15 EEA27622.1 - 0.069 13.2 0.4 0.18 11.8 0.4 1.7 1 0 0 1 1 1 0 MuDR family transposase UAA PF08449.11 EEA27623.1 - 9.9e-40 136.6 16.9 1.6e-39 135.9 16.9 1.3 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EEA27623.1 - 2.1e-08 34.4 22.2 2e-05 24.8 7.7 3.2 3 1 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EEA27623.1 - 6.4e-06 25.5 3.7 0.013 14.7 0.7 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.16 EEA27623.1 - 0.065 12.6 6.5 1.6 8.0 0.6 2.2 2 0 0 2 2 2 0 Triose-phosphate Transporter family Sen15 PF09631.10 EEA27624.1 - 2.5e-17 63.0 0.0 1.2e-15 57.6 0.0 2.2 1 1 0 1 1 1 1 Sen15 protein VASt PF16016.5 EEA27625.1 - 4.3e-37 127.9 0.2 1e-36 126.7 0.2 1.7 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 EEA27625.1 - 9.6e-17 61.5 0.1 1.8e-16 60.6 0.1 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EEA27625.1 - 4.4e-08 33.6 0.1 1.6e-07 31.8 0.1 2.1 1 0 0 1 1 1 1 PH domain GRAM PF02893.20 EEA27625.1 - 0.00072 19.4 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 GRAM domain BAR PF03114.18 EEA27625.1 - 0.0056 16.3 0.3 0.011 15.4 0.3 1.5 1 0 0 1 1 1 1 BAR domain VASt PF16016.5 EEA27626.1 - 6.7e-34 117.5 0.4 1.5e-33 116.4 0.4 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 EEA27626.1 - 8e-17 61.7 0.2 1.3e-16 61.1 0.2 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EEA27626.1 - 3.6e-08 33.8 0.1 1.1e-07 32.3 0.1 1.9 2 0 0 2 2 2 1 PH domain GRAM PF02893.20 EEA27626.1 - 0.00054 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 GRAM domain BAR PF03114.18 EEA27626.1 - 0.0041 16.8 0.3 0.0077 15.9 0.3 1.4 1 0 0 1 1 1 1 BAR domain Kri1_C PF12936.7 EEA27627.1 - 3.5e-31 107.2 0.1 3.5e-31 107.2 0.1 4.2 3 1 1 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 EEA27627.1 - 2.2e-30 105.3 22.6 2.2e-30 105.3 22.6 5.8 6 1 0 6 6 6 1 KRI1-like family Mito_carr PF00153.27 EEA27628.1 - 1.3e-63 210.9 6.6 2e-22 78.9 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 EEA27629.1 - 9e-55 182.6 5.7 1.5e-22 79.4 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Stb3 PF10330.9 EEA27631.1 - 4.8e-39 132.3 0.0 7.7e-39 131.6 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein CoA_transf_3 PF02515.17 EEA27632.1 - 5.1e-43 147.6 0.0 1.9e-40 139.2 0.0 2.2 2 0 0 2 2 2 2 CoA-transferase family III SnoaL_2 PF12680.7 EEA27633.1 - 0.0031 18.1 0.1 0.0045 17.6 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain Fungal_trans PF04082.18 EEA27634.1 - 1.4e-20 73.5 0.4 3.8e-20 72.0 0.2 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27634.1 - 5.4e-07 29.6 10.9 9.7e-07 28.8 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_1 PF00561.20 EEA27635.1 - 4.8e-25 88.7 0.0 1.1e-21 77.6 0.1 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA27635.1 - 9.2e-20 70.9 0.4 4.7e-19 68.6 0.4 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA27635.1 - 7.9e-17 62.6 0.0 1.7e-16 61.5 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EEA27635.1 - 3.9e-06 26.7 0.2 1.1e-05 25.3 0.2 1.7 1 1 1 2 2 2 1 Putative esterase Ndr PF03096.14 EEA27635.1 - 5.7e-06 25.2 0.0 7.6e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 Ndr family DUF915 PF06028.11 EEA27635.1 - 2.3e-05 23.9 0.0 0.00028 20.3 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase2 PF12740.7 EEA27635.1 - 9.2e-05 21.5 0.3 0.00027 19.9 0.3 1.7 1 1 0 1 1 1 1 Chlorophyllase enzyme DLH PF01738.18 EEA27635.1 - 0.00021 21.0 0.1 0.12 11.9 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EEA27635.1 - 0.00084 18.9 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Chlorophyllase PF07224.11 EEA27635.1 - 0.0013 17.8 1.2 0.0029 16.7 1.2 1.7 1 1 0 1 1 1 1 Chlorophyllase Lipase_3 PF01764.25 EEA27635.1 - 0.0022 17.9 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.20 EEA27635.1 - 0.0034 17.5 0.0 0.0047 17.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.7 EEA27635.1 - 0.0049 16.7 0.1 0.011 15.6 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family PAF-AH_p_II PF03403.13 EEA27635.1 - 0.0086 14.6 1.8 0.043 12.3 0.1 2.0 1 1 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II PGAP1 PF07819.13 EEA27635.1 - 0.01 15.6 1.1 0.022 14.5 0.1 1.9 2 0 0 2 2 2 1 PGAP1-like protein BAAT_C PF08840.11 EEA27635.1 - 0.012 15.6 0.1 0.034 14.0 0.1 1.7 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.12 EEA27635.1 - 0.014 14.5 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) LIDHydrolase PF10230.9 EEA27635.1 - 0.014 14.9 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 EEA27635.1 - 0.022 14.6 0.1 0.051 13.4 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_3 PF07859.13 EEA27635.1 - 0.022 14.6 0.1 0.031 14.1 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EEA27635.1 - 0.026 14.4 0.9 2 8.2 0.0 2.6 2 1 0 3 3 3 0 Phospholipase/Carboxylesterase UPF0227 PF05728.12 EEA27635.1 - 0.032 14.2 0.2 0.068 13.1 0.2 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF676 PF05057.14 EEA27635.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.15 EEA27635.1 - 0.16 11.1 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Asp2 PF16929.5 EEA27635.1 - 0.21 10.5 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Dioxygenase_C PF00775.21 EEA27636.1 - 8.9e-48 162.1 0.1 1.2e-47 161.7 0.1 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EEA27636.1 - 3.3e-27 94.1 0.1 5e-27 93.5 0.1 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 EEA27636.1 - 2.8e-06 27.5 0.0 8.5e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EEA27636.1 - 0.022 15.1 0.0 0.042 14.2 0.0 1.4 1 0 0 1 1 1 0 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EEA27636.1 - 0.028 14.4 0.2 0.94 9.5 0.2 2.6 2 1 0 2 2 2 0 CarboxypepD_reg-like domain PTS_2-RNA PF01885.16 EEA27637.1 - 2e-62 210.5 0.0 2.6e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family FAD_binding_3 PF01494.19 EEA27638.1 - 1.9e-57 195.1 0.0 2.4e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EEA27638.1 - 1.6e-08 33.7 0.1 0.00063 18.6 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein DAO PF01266.24 EEA27638.1 - 1.7e-07 31.1 0.1 0.002 17.8 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA27638.1 - 3.9e-05 24.1 0.8 0.34 11.5 0.2 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA27638.1 - 0.00016 20.9 0.2 0.055 12.5 0.0 2.9 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA27638.1 - 0.00047 19.5 0.0 0.29 10.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA27638.1 - 0.00053 20.2 0.1 0.0021 18.3 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EEA27638.1 - 0.0025 17.1 0.0 0.0061 15.9 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EEA27638.1 - 0.022 13.8 0.0 0.043 12.9 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase ApbA PF02558.16 EEA27638.1 - 0.049 13.3 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 EEA27638.1 - 0.054 12.3 0.2 0.49 9.2 0.1 2.0 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EEA27638.1 - 0.068 12.2 1.2 0.11 11.6 0.1 1.9 3 0 0 3 3 3 0 Lycopene cyclase protein K_oxygenase PF13434.6 EEA27638.1 - 0.12 11.5 0.0 0.24 10.5 0.0 1.5 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) OrsD PF12013.8 EEA27639.1 - 2.3e-26 92.5 0.2 5.5e-26 91.3 0.2 1.7 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_12 PF18658.1 EEA27639.1 - 0.01 15.4 0.2 0.084 12.5 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EEA27639.1 - 1.9 9.5 5.1 5.1 8.2 0.4 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger ADH_zinc_N PF00107.26 EEA27640.1 - 3.2e-11 43.3 0.2 8.1e-11 42.0 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA27640.1 - 3.4e-10 39.8 0.9 2.5e-09 37.0 0.2 2.6 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain Topoisom_bac PF01131.20 EEA27641.1 - 2.5e-103 346.3 0.0 1.2e-97 327.6 0.0 2.1 2 0 0 2 2 2 2 DNA topoisomerase Toprim PF01751.22 EEA27641.1 - 3.8e-19 68.8 0.0 7.7e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Toprim domain DUF1295 PF06966.12 EEA27642.1 - 3.6e-39 134.7 9.2 5.3e-39 134.1 9.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Fungal_trans_2 PF11951.8 EEA27643.1 - 1.4e-08 34.0 3.6 7.6e-07 28.3 0.6 2.5 2 1 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27643.1 - 1.5e-06 28.2 12.9 2.9e-06 27.3 12.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Jagunal PF07086.12 EEA27644.1 - 0.0093 16.1 0.5 0.0093 16.1 0.5 2.1 1 1 1 2 2 2 1 Jagunal, ER re-organisation during oogenesis NADH-u_ox-rdase PF10785.9 EEA27644.1 - 0.076 13.7 1.1 0.24 12.1 0.2 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit UPF0242 PF06785.11 EEA27644.1 - 0.26 11.4 1.4 0.45 10.6 1.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DSPc PF00782.20 EEA27646.1 - 2.5e-22 79.1 0.0 9.1e-20 70.8 0.0 2.3 1 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA27646.1 - 0.21 11.1 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Ank_5 PF13857.6 EEA27647.1 - 1.4e-10 41.2 0.1 9.1e-09 35.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA27647.1 - 3.6e-07 30.6 0.0 2.2e-05 24.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA27647.1 - 2.2e-06 27.6 0.2 2.5e-05 24.3 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EEA27647.1 - 5.5e-06 26.9 0.1 1e-05 26.0 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA27647.1 - 0.002 18.5 0.1 0.0052 17.2 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeat VHL_C PF17211.3 EEA27647.1 - 0.07 13.2 0.1 4.2 7.4 0.0 2.4 2 0 0 2 2 2 0 VHL box domain tRNA_lig_CPD PF08302.11 EEA27648.1 - 4.8e-94 314.6 0.5 7e-94 314.0 0.5 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.10 EEA27648.1 - 9.1e-86 287.2 0.1 1.7e-85 286.3 0.1 1.5 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 EEA27648.1 - 8.2e-50 169.2 0.7 1.6e-49 168.2 0.7 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_18 PF13238.6 EEA27648.1 - 0.042 14.4 0.5 0.71 10.4 0.1 2.9 3 0 0 3 3 3 0 AAA domain FlpD PF02662.16 EEA27648.1 - 0.057 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit AAA PF00004.29 EEA27648.1 - 0.1 13.0 0.0 0.45 10.9 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Got1 PF04178.12 EEA27649.1 - 3e-35 121.1 14.8 3.9e-35 120.7 14.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2070 PF09843.9 EEA27649.1 - 8.3 4.6 5.8 10 4.3 5.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Got1 PF04178.12 EEA27650.1 - 1.3e-23 83.6 4.1 1.9e-23 83.1 4.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family HLH PF00010.26 EEA27651.1 - 2.4e-12 46.6 0.0 8.6e-12 44.8 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mito_carr PF00153.27 EEA27652.1 - 8e-67 221.2 0.7 1e-24 86.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein AIP3 PF03915.13 EEA27654.1 - 3.4e-158 527.1 6.9 4.7e-158 526.6 6.9 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 NPV_P10 PF05531.12 EEA27654.1 - 0.0021 18.5 1.0 0.026 15.0 0.0 3.1 3 0 0 3 3 3 1 Nucleopolyhedrovirus P10 protein Lectin_N PF03954.14 EEA27654.1 - 0.0056 16.4 0.0 0.019 14.7 0.0 2.0 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 EEA27654.1 - 0.24 11.5 2.5 2.2 8.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Sec34 PF04136.15 EEA27654.1 - 0.54 10.1 3.1 0.91 9.4 0.1 2.7 4 0 0 4 4 4 0 Sec34-like family Syntaxin PF00804.25 EEA27654.1 - 1.6 8.3 8.0 4.7 6.8 0.0 3.9 4 0 0 4 4 4 0 Syntaxin Draxin PF15550.6 EEA27654.1 - 7.6 6.3 7.5 9.8 5.9 5.3 2.3 2 0 0 2 2 2 0 Draxin LsmAD PF06741.13 EEA27655.1 - 2e-27 95.5 1.7 2e-27 95.5 1.7 2.2 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 EEA27655.1 - 2.3e-20 72.5 0.4 4.7e-20 71.5 0.4 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 EEA27655.1 - 0.072 12.8 0.8 0.3 10.8 0.5 2.2 1 1 1 2 2 2 0 Ataxin-2 C-terminal region Pkinase PF00069.25 EEA27656.1 - 8.1e-11 41.8 0.0 1.3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EEA27656.1 - 9.6e-08 31.7 0.9 0.11 12.8 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 EEA27656.1 - 7.1e-07 29.4 0.0 2.6e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EEA27656.1 - 1.3e-05 25.6 0.1 0.027 15.0 0.0 3.3 3 0 0 3 3 3 2 HEAT-like repeat Pkinase_Tyr PF07714.17 EEA27656.1 - 0.00011 21.5 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 EEA27656.1 - 0.015 15.7 1.6 0.59 10.6 0.0 3.7 2 1 2 4 4 4 0 HEAT repeats Kinase-like PF14531.6 EEA27656.1 - 0.05 12.9 0.0 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like zf-FPG_IleRS PF06827.14 EEA27657.1 - 0.062 13.2 0.5 8.7 6.3 0.0 2.7 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS DUF3810 PF12725.7 EEA27657.1 - 0.75 9.1 9.7 4.6 6.5 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3810) CAP PF00188.26 EEA27657.1 - 2.8 8.8 5.5 0.66 10.8 1.0 2.5 3 0 0 3 3 3 0 Cysteine-rich secretory protein family Acetyltransf_1 PF00583.25 EEA27658.1 - 2.2e-11 44.0 0.0 3.6e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EEA27658.1 - 2.1e-07 30.8 0.1 3.7e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EEA27658.1 - 1.4e-06 28.2 0.1 2e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA27658.1 - 1.7e-05 25.1 0.0 3.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA27658.1 - 0.0076 16.3 0.2 0.012 15.6 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain BMFP PF04380.13 EEA27658.1 - 0.16 12.5 0.4 0.53 10.8 0.1 1.9 2 0 0 2 2 2 0 Membrane fusogenic activity Bac_rhodopsin PF01036.18 EEA27659.1 - 1.3e-32 113.1 24.9 1.8e-32 112.7 24.9 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein TMEM220 PF15071.6 EEA27659.1 - 0.096 13.5 9.2 1.1 10.0 0.5 2.6 2 0 0 2 2 2 0 Transmembrane family 220, helix SUR7 PF06687.12 EEA27661.1 - 1.6e-45 155.4 12.1 2e-45 155.0 12.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family Tetraspanin PF00335.20 EEA27661.1 - 2.8 7.6 13.1 5 6.8 9.1 2.6 3 0 0 3 3 3 0 Tetraspanin family DUF202 PF02656.15 EEA27663.1 - 7.9e-14 51.9 8.5 1.4e-13 51.1 5.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4131 PF13567.6 EEA27663.1 - 7.5 6.2 8.2 1.4 8.6 1.7 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) DUF202 PF02656.15 EEA27664.1 - 7.9e-14 51.9 8.5 1.4e-13 51.1 5.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4131 PF13567.6 EEA27664.1 - 7.5 6.2 8.2 1.4 8.6 1.7 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) DUF202 PF02656.15 EEA27665.1 - 7.9e-14 51.9 8.5 1.4e-13 51.1 5.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4131 PF13567.6 EEA27665.1 - 7.5 6.2 8.2 1.4 8.6 1.7 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) Tctex-1 PF03645.13 EEA27666.1 - 1.9e-35 121.2 0.0 2.3e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Tctex-1 PF03645.13 EEA27667.1 - 1.9e-35 121.2 0.0 2.3e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Tctex-1 PF03645.13 EEA27668.1 - 1.9e-35 121.2 0.0 2.3e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family WD40 PF00400.32 EEA27669.1 - 4.9e-40 134.8 18.3 1.3e-10 41.7 0.1 8.2 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA27669.1 - 8.1e-11 42.1 0.9 0.023 15.0 0.1 4.5 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 EEA27669.1 - 1.8e-07 30.4 0.5 1.6e-06 27.3 0.1 2.6 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 EEA27669.1 - 1e-05 24.4 6.5 0.22 10.1 0.1 4.9 4 1 0 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EEA27669.1 - 0.00051 19.1 0.1 0.54 9.2 0.0 3.7 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 EEA27669.1 - 0.024 14.4 4.4 0.36 10.5 0.1 4.1 3 1 2 5 5 5 0 TUP1-like enhancer of split Frtz PF11768.8 EEA27669.1 - 0.025 12.9 0.0 0.059 11.7 0.0 1.5 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF1513 PF07433.11 EEA27669.1 - 0.16 11.0 1.5 2.7 7.0 0.0 2.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1513) DUF1631 PF07793.11 EEA27669.1 - 1.3 7.4 4.5 1.6 7.1 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) TPR_12 PF13424.6 EEA27671.1 - 9.8e-13 48.2 5.9 2.2e-07 31.0 0.0 4.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA27671.1 - 6.4e-06 25.8 1.5 1.9e-05 24.3 0.7 2.0 1 1 0 1 1 1 1 MalT-like TPR region TPR_2 PF07719.17 EEA27671.1 - 8.6e-06 25.5 6.2 0.0021 18.0 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA27671.1 - 2.1e-05 24.3 5.9 0.007 16.2 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA27671.1 - 0.00015 21.4 1.9 0.015 15.1 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA27671.1 - 0.00098 19.7 5.5 1.5 9.6 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA27671.1 - 0.0012 18.7 7.7 0.033 14.2 0.2 4.9 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 EEA27671.1 - 0.0047 17.4 8.4 1.2 9.9 0.4 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA27671.1 - 0.005 17.3 0.1 0.19 12.3 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat CBP_GIL PF10995.8 EEA27671.1 - 0.03 13.0 0.2 0.045 12.4 0.2 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis GIL TPR_8 PF13181.6 EEA27671.1 - 0.047 13.9 0.1 6.8 7.2 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA27671.1 - 0.068 14.0 6.6 4.5 8.3 0.2 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat RPN7 PF10602.9 EEA27671.1 - 0.087 12.5 1.2 1.2 8.8 0.2 2.5 2 0 0 2 2 2 0 26S proteasome subunit RPN7 cwf18 PF08315.12 EEA27672.1 - 5e-43 147.0 8.7 7.6e-43 146.4 8.7 1.3 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor zf-CCHC_3 PF13917.6 EEA27673.1 - 1.9e-10 40.5 1.6 1.9e-10 40.5 1.6 2.0 2 0 0 2 2 2 1 Zinc knuckle SUZ PF12752.7 EEA27674.1 - 3.1e-14 53.4 9.2 3.1e-14 53.4 9.2 3.9 4 1 0 4 4 4 1 SUZ domain R3H PF01424.22 EEA27674.1 - 4.9e-08 32.8 0.0 1.4e-07 31.4 0.0 1.8 1 0 0 1 1 1 1 R3H domain SUZ PF12752.7 EEA27675.1 - 3.1e-14 53.4 9.2 3.1e-14 53.4 9.2 3.9 4 1 0 4 4 4 1 SUZ domain R3H PF01424.22 EEA27675.1 - 4.9e-08 32.8 0.0 1.4e-07 31.4 0.0 1.8 1 0 0 1 1 1 1 R3H domain Ribosomal_L17 PF01196.19 EEA27676.1 - 7.1e-35 119.8 0.8 1e-34 119.3 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L17 Molybdopterin_N PF18364.1 EEA27676.1 - 0.06 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin oxidoreductase N-terminal domain TRAF_BIRC3_bd PF16673.5 EEA27676.1 - 0.081 12.7 6.3 0.71 9.7 2.0 2.6 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF1682 PF07946.14 EEA27676.1 - 2.4 7.3 10.9 3.9 6.6 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) AIM5 PF17050.5 EEA27677.1 - 4.9e-12 46.5 1.2 7.1e-12 46.0 1.2 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 Ribosomal_L1 PF00687.21 EEA27677.1 - 0.033 13.9 0.1 0.048 13.4 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L1p/L10e family DUF5315 PF17242.2 EEA27678.1 - 1.2e-24 85.9 4.2 1.2e-24 85.9 4.2 1.8 2 0 0 2 2 2 1 Disordered region of unknown function (DUF5315) Secretin_N_2 PF07655.13 EEA27678.1 - 0.1 13.2 3.2 1.5 9.5 0.7 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain Cluap1 PF10234.9 EEA27678.1 - 0.21 11.0 4.6 0.29 10.5 4.6 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 Ribosom_S12_S23 PF00164.25 EEA27679.1 - 1.3e-50 169.8 0.8 1.6e-50 169.5 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 IF-2B PF01008.17 EEA27680.1 - 2.2e-61 207.6 2.5 1.5e-37 129.4 0.3 2.8 2 1 0 2 2 2 2 Initiation factor 2 subunit family NIF PF03031.18 EEA27681.1 - 1.1e-57 194.2 0.0 1.7e-57 193.6 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Aminotran_5 PF00266.19 EEA27682.1 - 5e-32 111.3 0.0 6.5e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V KR PF08659.10 EEA27682.1 - 0.045 13.7 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 KR domain B12-binding PF02310.19 EEA27682.1 - 0.084 12.9 0.1 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 B12 binding domain Metallophos_2 PF12850.7 EEA27683.1 - 1e-12 48.5 0.0 1.3e-12 48.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_2 PF12850.7 EEA27684.1 - 1e-12 48.5 0.0 1.3e-12 48.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_2 PF12850.7 EEA27685.1 - 1e-12 48.5 0.0 1.3e-12 48.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RRM_1 PF00076.22 EEA27686.1 - 5.6e-16 58.1 0.0 1.1e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DivIC PF04977.15 EEA27686.1 - 0.02 14.6 2.1 0.031 14.0 2.1 1.2 1 0 0 1 1 1 0 Septum formation initiator Nup35_RRM_2 PF14605.6 EEA27686.1 - 0.022 14.7 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif ZapB PF06005.12 EEA27686.1 - 0.035 14.5 2.9 0.061 13.8 2.9 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF724 PF05266.14 EEA27686.1 - 0.084 12.7 2.0 0.11 12.3 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CASP_C PF08172.12 EEA27686.1 - 0.087 12.1 0.1 0.11 11.8 0.1 1.1 1 0 0 1 1 1 0 CASP C terminal YabA PF06156.13 EEA27686.1 - 0.12 13.0 0.2 0.18 12.5 0.2 1.2 1 0 0 1 1 1 0 Initiation control protein YabA DUF5082 PF16888.5 EEA27686.1 - 0.21 11.9 2.9 0.29 11.4 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) GRP PF07172.11 EEA27686.1 - 0.5 11.1 11.7 0.15 12.7 8.6 1.7 2 0 0 2 2 2 0 Glycine rich protein family HECT PF00632.25 EEA27687.1 - 4.5e-99 331.8 0.0 6.3e-99 331.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EEA27687.1 - 2.6e-34 117.0 22.0 2.9e-12 46.5 2.7 4.2 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EEA27687.1 - 1.3e-19 70.4 0.0 3.4e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain GGDEF PF00990.21 EEA27687.1 - 0.084 12.6 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Diguanylate cyclase, GGDEF domain Macoilin PF09726.9 EEA27688.1 - 1.9 6.9 8.2 1.9 6.9 8.2 1.0 1 0 0 1 1 1 0 Macoilin family PPR_2 PF13041.6 EEA27689.1 - 5.8e-19 68.0 1.1 3.2e-06 27.2 0.0 5.0 3 2 2 5 5 5 3 PPR repeat family PPR PF01535.20 EEA27689.1 - 8.3e-10 38.2 0.3 0.0082 16.3 0.0 6.0 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 EEA27689.1 - 1.6e-08 34.5 0.3 0.014 15.4 0.0 4.7 3 2 2 5 5 5 4 Pentatricopeptide repeat domain PPR_long PF17177.4 EEA27689.1 - 1.5e-05 24.5 2.0 0.027 13.8 0.5 2.8 2 1 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EEA27689.1 - 0.009 15.7 0.1 7.4 6.4 0.0 3.2 2 0 0 2 2 2 2 PPR repeat TFIID-18kDa PF02269.16 EEA27690.1 - 4.3e-22 77.9 0.0 7.3e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-S PF15630.6 EEA27690.1 - 0.00045 20.6 0.1 0.00093 19.5 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EEA27690.1 - 0.0006 19.9 0.3 0.0014 18.8 0.2 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EEA27690.1 - 0.0021 18.4 0.1 0.0021 18.4 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EEA27690.1 - 0.0022 18.0 0.0 0.0036 17.3 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EEA27690.1 - 0.016 15.3 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 EEA27690.1 - 0.017 15.4 0.1 0.017 15.4 0.1 1.9 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 EEA27690.1 - 0.024 14.8 0.1 0.041 14.0 0.1 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) JAB PF01398.21 EEA27691.1 - 4.1e-20 71.9 0.0 8.2e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EEA27691.1 - 5e-19 68.8 0.2 8.8e-19 68.0 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 EEA27691.1 - 6e-05 23.2 0.0 0.00015 21.8 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) UTP25 PF06862.12 EEA27692.1 - 8.7e-197 654.6 0.2 1.1e-196 654.3 0.2 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Helicase_C PF00271.31 EEA27692.1 - 0.0072 16.7 0.0 0.061 13.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain EamA PF00892.20 EEA27693.1 - 6.1e-16 58.8 23.0 9e-12 45.3 5.4 2.8 2 1 0 2 2 2 2 EamA-like transporter family EamA PF00892.20 EEA27694.1 - 6.6e-16 58.7 23.0 9.3e-12 45.3 5.4 2.8 2 1 0 2 2 2 2 EamA-like transporter family Granulin PF00396.18 EEA27695.1 - 0.046 14.1 1.7 0.097 13.0 1.7 1.4 1 0 0 1 1 1 0 Granulin CTP_transf_like PF01467.26 EEA27696.1 - 3.1e-30 105.3 0.0 5.9e-30 104.4 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like PP2C PF00481.21 EEA27697.1 - 2e-81 273.5 0.0 3e-81 272.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 EEA27698.1 - 1.6e-81 273.7 0.0 2.4e-81 273.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C He_PIG PF05345.12 EEA27699.1 - 2.8e-18 65.8 16.0 2.5e-06 27.6 0.3 4.9 4 0 0 4 4 4 4 Putative Ig domain SKG6 PF08693.10 EEA27699.1 - 0.03 13.7 5.5 0.065 12.6 5.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF5305 PF17231.2 EEA27699.1 - 0.1 12.0 0.3 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5305) EphA2_TM PF14575.6 EEA27699.1 - 0.18 12.7 0.4 0.76 10.7 0.4 2.2 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Acetyltransf_1 PF00583.25 EEA27700.1 - 8.7e-13 48.5 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA27700.1 - 6.9e-10 39.2 0.0 9.7e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA27700.1 - 4.1e-08 33.2 0.0 4.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA27700.1 - 1.5e-05 25.0 0.0 3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EEA27700.1 - 5.8e-05 23.0 0.0 0.00012 22.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 EEA27700.1 - 0.00019 21.2 0.2 0.00032 20.4 0.2 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_15 PF17013.5 EEA27700.1 - 0.017 14.6 0.0 0.022 14.2 0.0 1.4 1 1 0 1 1 1 0 Putative acetyl-transferase Itfg2 PF15907.5 EEA27700.1 - 0.04 13.0 0.0 0.043 12.8 0.0 1.1 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 Acetyltransf_8 PF13523.6 EEA27700.1 - 0.14 11.8 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MOZART1 PF12554.8 EEA27701.1 - 3.2e-24 84.5 0.8 3.6e-24 84.3 0.8 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated PRA-PH PF01503.17 EEA27701.1 - 0.055 13.9 0.0 4.3 7.9 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase CUE PF02845.16 EEA27702.1 - 2.5e-11 43.0 0.0 4.2e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain CUE PF02845.16 EEA27703.1 - 1.6e-11 43.7 0.0 2.6e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 CUE domain HA2 PF04408.23 EEA27704.1 - 1e-16 61.2 0.0 1.9e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA27704.1 - 3.2e-14 53.1 0.0 6.5e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA27704.1 - 1.3e-11 44.8 0.0 2.8e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EEA27704.1 - 1.4e-05 25.3 0.0 3.9e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA27704.1 - 7.4e-05 22.5 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA27704.1 - 0.00013 22.4 0.1 0.00027 21.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EEA27704.1 - 0.00014 21.7 0.1 0.00033 20.5 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase cobW PF02492.19 EEA27704.1 - 0.016 14.8 0.3 0.4 10.3 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Herpes_ori_bp PF02399.15 EEA27704.1 - 0.03 12.4 0.0 0.046 11.8 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein AAA_14 PF13173.6 EEA27704.1 - 0.033 14.2 0.2 3.1 7.8 0.2 2.4 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EEA27704.1 - 0.064 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 EEA27704.1 - 0.12 12.9 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 EEA27704.1 - 0.13 11.2 0.1 0.23 10.3 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 EEA27704.1 - 0.14 11.2 0.0 0.29 10.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 EEA27704.1 - 0.16 11.9 0.1 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain FBPase_2 PF06874.11 EEA27704.1 - 0.2 9.9 0.1 0.31 9.3 0.1 1.2 1 0 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase Zeta_toxin PF06414.12 EEA27704.1 - 0.32 10.2 1.0 0.74 9.1 0.1 1.9 1 1 1 2 2 2 0 Zeta toxin PITH PF06201.13 EEA27705.1 - 1e-43 149.2 0.0 1.2e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 PITH domain FlaA PF04620.12 EEA27705.1 - 0.11 12.1 0.0 0.44 10.2 0.0 1.8 2 0 0 2 2 2 0 Flagellar filament outer layer protein Flaa Snf7 PF03357.21 EEA27706.1 - 3e-33 114.8 13.6 3e-33 114.8 13.6 1.8 2 0 0 2 2 2 1 Snf7 Adenine_deam_C PF13382.6 EEA27706.1 - 0.04 13.3 0.5 0.073 12.4 0.5 1.4 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain Silic_transp PF03842.13 EEA27706.1 - 0.35 9.1 2.3 0.46 8.7 2.3 1.1 1 0 0 1 1 1 0 Silicon transporter AAA PF00004.29 EEA27707.1 - 2.1e-90 300.0 0.0 3.9e-44 150.3 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA27707.1 - 1.4e-20 72.8 2.0 4.8e-09 35.9 0.2 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EEA27707.1 - 1.1e-13 51.2 0.0 2.8e-06 27.2 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA27707.1 - 1.9e-13 50.9 0.2 0.0081 16.4 0.0 5.5 2 2 1 4 4 4 2 AAA domain AAA_16 PF13191.6 EEA27707.1 - 2.9e-13 50.6 1.7 0.00014 22.3 0.1 4.4 3 2 0 3 3 2 2 AAA ATPase domain AAA_2 PF07724.14 EEA27707.1 - 1.1e-12 48.5 0.0 9.5e-05 22.6 0.0 3.5 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EEA27707.1 - 8.2e-11 42.1 0.7 0.00064 19.7 0.1 4.2 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EEA27707.1 - 3.7e-10 40.1 0.0 0.00013 22.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 EEA27707.1 - 4e-09 36.8 0.0 0.0017 18.7 0.0 3.5 3 1 0 3 3 3 2 RNA helicase TIP49 PF06068.13 EEA27707.1 - 8e-09 35.2 0.0 0.00034 19.9 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 EEA27707.1 - 9.1e-08 32.2 0.0 0.0054 16.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EEA27707.1 - 2.7e-07 30.2 0.3 0.018 14.4 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EEA27707.1 - 2.8e-07 30.4 0.0 0.025 14.3 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 EEA27707.1 - 4.4e-07 30.3 0.0 0.006 16.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 EEA27707.1 - 6.2e-07 29.3 0.0 0.005 16.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EEA27707.1 - 1.2e-06 28.5 0.1 0.022 14.7 0.0 3.5 4 0 0 4 4 3 2 NACHT domain AAA_18 PF13238.6 EEA27707.1 - 1.9e-06 28.5 0.0 0.053 14.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EEA27707.1 - 2.1e-06 27.2 0.0 0.038 13.3 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin TsaE PF02367.17 EEA27707.1 - 3.9e-06 26.9 0.0 0.033 14.2 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EEA27707.1 - 8.9e-06 25.4 0.8 0.52 9.8 0.0 3.6 2 1 0 3 3 3 2 AAA domain ATPase PF06745.13 EEA27707.1 - 1.6e-05 24.4 0.0 0.36 10.1 0.0 3.3 2 1 0 3 3 3 2 KaiC ABC_tran PF00005.27 EEA27707.1 - 2.4e-05 24.9 0.1 0.34 11.4 0.0 3.0 3 0 0 3 3 2 2 ABC transporter AAA_7 PF12775.7 EEA27707.1 - 3.5e-05 23.4 0.0 0.15 11.5 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region Cytidylate_kin2 PF13189.6 EEA27707.1 - 3.7e-05 23.9 0.2 0.0039 17.3 0.0 2.8 3 0 0 3 3 2 1 Cytidylate kinase-like family AAA_17 PF13207.6 EEA27707.1 - 4.3e-05 24.0 2.0 0.1 13.0 0.0 4.0 4 1 0 4 4 3 1 AAA domain Rad17 PF03215.15 EEA27707.1 - 9.8e-05 22.3 0.0 0.53 10.2 0.0 2.7 2 0 0 2 2 2 2 Rad17 P-loop domain NB-ARC PF00931.22 EEA27707.1 - 9.9e-05 21.6 0.0 1 8.5 0.0 3.5 3 0 0 3 3 3 2 NB-ARC domain AFG1_ATPase PF03969.16 EEA27707.1 - 0.0001 21.3 0.0 0.026 13.4 0.0 2.4 2 0 0 2 2 2 1 AFG1-like ATPase PhoH PF02562.16 EEA27707.1 - 0.00011 21.8 0.0 0.15 11.5 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein Sigma54_activat PF00158.26 EEA27707.1 - 0.00016 21.4 0.0 0.28 10.9 0.0 2.9 2 1 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.11 EEA27707.1 - 0.00031 20.2 0.0 0.26 10.7 0.0 3.3 3 0 0 3 3 3 1 Bacterial TniB protein ATPase_2 PF01637.18 EEA27707.1 - 0.00034 20.6 0.4 2 8.3 0.0 4.0 3 2 1 4 4 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EEA27707.1 - 0.00044 20.0 0.0 0.87 9.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 EEA27707.1 - 0.00093 18.4 0.0 1.5 7.9 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EEA27707.1 - 0.00097 19.0 0.7 2 8.2 0.0 3.0 3 0 0 3 3 3 2 AAA domain Sigma54_activ_2 PF14532.6 EEA27707.1 - 0.0012 18.9 0.1 2.4 8.3 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain DUF815 PF05673.13 EEA27707.1 - 0.0013 17.9 0.0 0.034 13.3 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 EEA27707.1 - 0.0018 18.0 0.0 1.7 8.3 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase SKI PF01202.22 EEA27707.1 - 0.0029 17.7 0.0 3.9 7.6 0.0 3.0 2 0 0 2 2 2 0 Shikimate kinase SRPRB PF09439.10 EEA27707.1 - 0.0095 15.4 0.0 14 5.1 0.0 3.5 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_19 PF13245.6 EEA27707.1 - 0.038 14.3 2.2 12 6.2 0.2 3.3 2 1 0 2 2 2 0 AAA domain CPT PF07931.12 EEA27707.1 - 0.054 13.3 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 EEA27707.1 - 0.083 12.8 0.0 11 5.9 0.0 3.0 2 1 1 3 3 3 0 NTPase PduV-EutP PF10662.9 EEA27707.1 - 0.14 11.9 0.0 10 5.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF2075 PF09848.9 EEA27707.1 - 0.14 11.3 0.0 8.9 5.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Vps4_C PF09336.10 EEA27707.1 - 0.16 12.0 0.2 7.3 6.7 0.0 3.4 3 1 0 3 3 3 0 Vps4 C terminal oligomerisation domain AAA_30 PF13604.6 EEA27707.1 - 0.18 11.5 0.3 26 4.5 0.0 2.7 3 0 0 3 3 2 0 AAA domain L27_1 PF09058.10 EEA27707.1 - 0.21 11.6 0.3 1.5 8.8 0.1 2.3 2 0 0 2 2 2 0 L27_1 BOP1NT PF08145.12 EEA27708.1 - 3.9e-106 354.7 6.3 3.9e-106 354.7 6.3 2.0 2 0 0 2 2 2 1 BOP1NT (NUC169) domain WD40 PF00400.32 EEA27708.1 - 4.8e-23 81.0 10.4 8.8e-10 39.0 0.3 5.7 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA27708.1 - 7.4e-06 26.2 0.0 0.0099 16.2 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain AAA_21 PF13304.6 EEA27708.1 - 0.78 9.5 3.9 1.4 8.6 3.9 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RRM_1 PF00076.22 EEA27709.1 - 1e-09 38.1 0.0 1.7e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA27709.1 - 0.00025 20.6 0.0 0.00055 19.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COX6B PF02297.17 EEA27710.1 - 1.9e-23 82.4 1.7 2.6e-23 82.0 1.7 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Abi_2 PF07751.11 EEA27710.1 - 0.027 14.7 0.4 0.03 14.6 0.4 1.1 1 0 0 1 1 1 0 Abi-like protein UBA_2 PF08587.11 EEA27710.1 - 0.077 13.1 2.5 2.6 8.2 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) SYS1 PF09801.9 EEA27711.1 - 2.4e-53 180.1 12.5 2.8e-53 179.9 12.5 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF4199 PF13858.6 EEA27711.1 - 0.55 10.6 11.6 18 5.7 0.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) TraL PF07178.11 EEA27711.1 - 0.61 10.6 6.6 1.4 9.5 1.7 2.4 2 0 0 2 2 2 0 TraL protein Aldolase_II PF00596.21 EEA27712.1 - 1e-47 162.5 0.1 1.3e-47 162.1 0.1 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain BsuBI_PstI_RE PF06616.11 EEA27712.1 - 0.14 11.4 0.0 5.2 6.3 0.0 2.2 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease domain COG5 PF10392.9 EEA27713.1 - 2.5e-39 134.5 4.3 2.5e-39 134.5 4.3 2.7 3 0 0 3 3 3 1 Golgi transport complex subunit 5 ACC_central PF08326.12 EEA27713.1 - 1e-05 24.0 0.4 0.0018 16.6 0.0 2.2 2 0 0 2 2 2 2 Acetyl-CoA carboxylase, central region COG2 PF06148.11 EEA27713.1 - 0.13 12.4 2.5 0.45 10.6 2.5 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Stomoxyn PF11585.8 EEA27713.1 - 0.21 11.6 3.1 0.47 10.5 3.1 1.5 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn adh_short PF00106.25 EEA27715.1 - 1.2e-38 132.5 0.2 1.5e-38 132.2 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA27715.1 - 3.2e-31 108.7 0.1 4.2e-31 108.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA27715.1 - 1.5e-05 25.0 0.1 8e-05 22.6 0.1 2.0 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EEA27715.1 - 0.0014 18.5 0.1 0.004 17.1 0.1 1.7 2 0 0 2 2 2 1 NAD(P)H-binding DFP PF04127.15 EEA27715.1 - 0.027 14.3 0.2 0.042 13.7 0.2 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Epimerase PF01370.21 EEA27715.1 - 0.045 13.2 0.0 0.1 12.1 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EEA27715.1 - 0.058 12.5 0.1 0.084 12.0 0.1 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain VBS PF08913.10 EEA27715.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 1 0 1 1 1 0 Vinculin Binding Site Pox_T4_C PF04490.12 EEA27715.1 - 0.17 12.1 0.1 0.26 11.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus zf-C2H2 PF00096.26 EEA27716.1 - 1.4e-05 25.2 12.1 0.0055 17.1 1.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA27716.1 - 0.00026 21.3 3.8 0.00026 21.3 3.8 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA27716.1 - 0.0013 19.4 11.5 0.069 14.0 2.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger TylF PF05711.11 EEA27716.1 - 0.23 10.7 0.0 0.34 10.1 0.0 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) zf-H2C2_5 PF13909.6 EEA27716.1 - 7.7 6.4 7.7 5.2 6.9 1.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain AA_permease_2 PF13520.6 EEA27718.1 - 1e-30 107.0 49.9 1.3e-30 106.6 49.9 1.0 1 0 0 1 1 1 1 Amino acid permease Apolipoprotein PF01442.18 EEA27719.1 - 0.00034 20.5 6.6 0.001 19.0 6.6 1.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 EEA27719.1 - 0.0032 18.0 9.6 0.29 11.8 1.7 2.3 1 1 0 2 2 2 2 Bacterial protein of unknown function (DUF883) Effector_1 PF04518.12 EEA27719.1 - 0.02 14.0 0.2 0.026 13.6 0.2 1.1 1 0 0 1 1 1 0 Effector from type III secretion system EDR1 PF14381.6 EEA27719.1 - 0.099 12.3 0.1 0.11 12.2 0.1 1.0 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 DUF2951 PF11166.8 EEA27719.1 - 0.11 12.7 1.3 2.9 8.2 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) Phasin PF05597.11 EEA27719.1 - 0.25 11.3 5.8 0.64 10.0 5.0 2.0 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) vATP-synt_E PF01991.18 EEA27719.1 - 3.1 7.1 13.1 7.8 5.8 3.6 2.4 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit VIT1 PF01988.19 EEA27721.1 - 0.79 9.6 8.1 0.96 9.3 8.1 1.5 1 1 0 1 1 1 0 VIT family CDT1_C PF16679.5 EEA27722.1 - 5.8e-20 71.5 0.0 1.6e-19 70.1 0.0 1.8 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain SET PF00856.28 EEA27723.1 - 3.9e-14 53.4 0.0 2.6e-13 50.7 0.0 2.2 1 1 0 1 1 1 1 SET domain SAF PF08666.12 EEA27723.1 - 0.027 15.1 0.0 12 6.7 0.0 2.3 2 0 0 2 2 2 0 SAF domain MutS_V PF00488.21 EEA27724.1 - 2.3e-81 272.4 0.1 3.8e-81 271.6 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EEA27724.1 - 3.1e-37 128.7 1.1 3.1e-37 128.7 1.1 2.0 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EEA27724.1 - 3.4e-19 69.5 0.9 1e-18 67.9 0.1 2.3 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EEA27724.1 - 3.6e-17 62.5 1.4 3.6e-17 62.5 1.4 2.7 4 0 0 4 4 4 1 MutS family domain IV MutS_I PF01624.20 EEA27724.1 - 1.3e-15 57.7 0.0 1.6e-14 54.1 0.0 2.6 2 0 0 2 2 2 1 MutS domain I SUR7 PF06687.12 EEA27724.1 - 0.073 12.7 0.0 0.53 9.9 0.0 2.1 2 1 0 2 2 2 0 SUR7/PalI family Sigma70_r2 PF04542.14 EEA27724.1 - 0.2 11.4 0.6 0.68 9.8 0.1 2.2 2 0 0 2 2 2 0 Sigma-70 region 2 Gpi1 PF05024.15 EEA27725.1 - 8.3e-79 264.0 7.9 1.7e-78 263.0 7.9 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) 7tm_1 PF00001.21 EEA27725.1 - 0.0075 15.6 0.4 0.017 14.4 0.4 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Myb_DNA-binding PF00249.31 EEA27726.1 - 0.072 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain DNA_pol_A_exo1 PF01612.20 EEA27727.1 - 2.4e-45 154.4 0.4 3.8e-45 153.8 0.4 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EEA27727.1 - 3.1e-27 95.1 0.2 3.1e-27 95.1 0.2 2.3 2 0 0 2 2 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 EEA27727.1 - 8.3e-11 41.7 0.0 3e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 HRDC domain Myc_N PF01056.18 EEA27727.1 - 0.00079 19.4 7.5 0.0012 18.9 7.5 1.4 1 0 0 1 1 1 1 Myc amino-terminal region SR-25 PF10500.9 EEA27727.1 - 0.0014 18.3 15.5 0.0024 17.5 15.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SAPS PF04499.15 EEA27727.1 - 0.041 12.7 2.2 0.06 12.1 2.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 EEA27727.1 - 0.085 11.1 18.2 0.14 10.3 18.2 1.3 1 0 0 1 1 1 0 Nop14-like family Serglycin PF04360.12 EEA27727.1 - 0.36 10.8 2.8 1 9.3 1.4 2.1 2 0 0 2 2 2 0 Serglycin DDHD PF02862.17 EEA27727.1 - 0.37 10.9 5.5 0.42 10.7 3.6 1.9 2 0 0 2 2 2 0 DDHD domain HGTP_anticodon2 PF12745.7 EEA27727.1 - 1.1 8.7 8.5 2.4 7.6 8.5 1.4 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Nucleo_P87 PF07267.11 EEA27727.1 - 1.9 7.2 10.1 3.6 6.3 10.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 EEA27727.1 - 1.9 6.7 12.9 3.1 6.0 12.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Red1 PF07964.11 EEA27727.1 - 2 6.5 14.7 3.2 5.9 14.7 1.2 1 0 0 1 1 1 0 Rec10 / Red1 DUF2151 PF10221.9 EEA27727.1 - 2.3 6.7 8.4 42 2.5 0.0 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator RR_TM4-6 PF06459.12 EEA27727.1 - 5.3 6.8 15.6 10 5.8 15.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RasGAP PF00616.19 EEA27728.1 - 1.3e-58 198.1 0.2 1.3e-58 198.1 0.2 2.1 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EEA27728.1 - 1.8e-30 105.9 2.1 1.8e-30 105.9 2.1 3.3 3 0 0 3 3 3 1 RasGAP C-terminus SOGA PF11365.8 EEA27728.1 - 0.1 13.7 4.5 0.8 10.9 0.4 3.3 2 0 0 2 2 2 0 Protein SOGA DUF4140 PF13600.6 EEA27728.1 - 0.75 10.3 3.9 0.52 10.8 0.8 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Med10 PF09748.9 EEA27728.1 - 2.4 8.1 6.1 0.59 10.1 0.4 2.8 3 0 0 3 3 3 0 Transcription factor subunit Med10 of Mediator complex GvpL_GvpF PF06386.11 EEA27728.1 - 2.5 8.0 6.0 1.7 8.5 0.7 2.5 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF CRAL_TRIO PF00650.20 EEA27729.1 - 1.2e-36 125.8 0.0 2e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA27729.1 - 8.2e-09 35.5 0.4 2.1e-08 34.2 0.4 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EEA27729.1 - 4.5e-05 23.6 0.0 7.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EEA27730.1 - 1.2e-36 125.8 0.0 2e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA27730.1 - 8.2e-09 35.5 0.4 2.1e-08 34.2 0.4 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EEA27730.1 - 4.5e-05 23.6 0.0 7.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Mis14 PF08641.12 EEA27731.1 - 2.2e-24 86.3 6.3 2.2e-24 86.3 6.3 3.0 3 1 0 3 3 3 1 Kinetochore protein Mis14 like FUSC PF04632.12 EEA27731.1 - 1.5 7.2 3.9 2.2 6.7 3.9 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pex24p PF06398.11 EEA27732.1 - 2.7e-05 23.3 9.2 3.8e-05 22.8 9.2 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF4476 PF14771.6 EEA27732.1 - 0.032 14.5 0.0 0.095 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) Seryl_tRNA_N PF02403.22 EEA27732.1 - 0.12 12.6 0.3 0.12 12.6 0.3 2.1 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain PPR_3 PF13812.6 EEA27733.1 - 4.2e-09 36.4 0.0 0.0017 18.4 0.0 2.9 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR_2 PF13041.6 EEA27733.1 - 2.4e-06 27.6 0.1 0.18 12.1 0.0 3.3 3 0 0 3 3 3 2 PPR repeat family PPR_long PF17177.4 EEA27733.1 - 0.00017 21.0 0.1 0.71 9.2 0.0 3.1 3 0 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP Acetyltransf_1 PF00583.25 EEA27734.1 - 2e-19 70.0 0.0 2.9e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA27734.1 - 1.5e-12 47.6 0.0 2.1e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA27734.1 - 6.5e-12 45.7 0.0 1e-11 45.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA27734.1 - 5.1e-10 39.2 0.1 8.4e-10 38.5 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EEA27734.1 - 1.2e-06 29.2 0.0 1.6e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EEA27734.1 - 2.4e-06 27.6 0.0 5.4e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EEA27734.1 - 2.3e-05 24.1 0.0 3.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA27734.1 - 0.00013 22.0 0.0 0.00025 21.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 EEA27734.1 - 0.0079 15.8 0.0 0.015 14.9 0.0 1.3 1 1 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_4 PF13420.7 EEA27734.1 - 0.027 14.6 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EEA27734.1 - 0.042 13.8 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 EEA27734.1 - 0.066 12.7 0.1 0.13 11.7 0.1 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase PanZ PF12568.8 EEA27734.1 - 0.09 12.5 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ LCAT PF02450.15 EEA27735.1 - 8.7e-111 370.8 0.3 1.1e-110 370.6 0.3 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 EEA27735.1 - 0.0007 19.2 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 EEA27735.1 - 0.043 13.4 0.6 0.18 11.4 0.1 2.0 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Lipase_2 PF01674.18 EEA27735.1 - 0.057 12.9 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 2) Hydrolase_4 PF12146.8 EEA27735.1 - 0.095 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EEA27735.1 - 0.099 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase PAP2_3 PF14378.6 EEA27736.1 - 4.6e-24 85.1 13.3 4.6e-24 85.1 13.3 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EEA27736.1 - 7.2e-10 38.8 4.1 7.2e-10 38.8 4.1 2.3 2 0 0 2 2 2 1 PAP2 superfamily VIT1 PF01988.19 EEA27737.1 - 3.6e-61 206.8 1.6 4.4e-61 206.5 1.6 1.1 1 0 0 1 1 1 1 VIT family MARVEL PF01284.23 EEA27737.1 - 0.011 15.8 0.6 0.018 15.1 0.6 1.4 1 0 0 1 1 1 0 Membrane-associating domain SLATT_fungal PF18142.1 EEA27737.1 - 0.15 12.1 0.1 0.32 11.0 0.1 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Abhydrolase_9_N PF15420.6 EEA27737.1 - 0.16 11.9 3.0 0.29 11.1 3.0 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus p450 PF00067.22 EEA27738.1 - 2.6e-40 138.6 0.0 4.2e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 MetallophosC PF16370.5 EEA27739.1 - 0.005 17.1 0.8 0.0057 16.9 0.8 1.1 1 0 0 1 1 1 1 C terminal of Calcineurin-like phosphoesterase SID-1_RNA_chan PF13965.6 EEA27739.1 - 0.016 13.7 0.1 0.016 13.7 0.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF1449 PF07290.11 EEA27739.1 - 0.029 14.0 0.2 0.04 13.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) DUF4834 PF16118.5 EEA27739.1 - 0.031 15.2 0.6 0.036 15.0 0.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) TMEMspv1-c74-12 PF11044.8 EEA27739.1 - 0.031 14.2 1.5 0.031 14.2 1.5 1.8 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Wzy_C PF04932.15 EEA27739.1 - 0.063 12.9 0.1 0.075 12.7 0.1 1.1 1 0 0 1 1 1 0 O-Antigen ligase Neur_chan_memb PF02932.16 EEA27739.1 - 0.11 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TMEM156 PF15106.6 EEA27739.1 - 0.28 10.6 2.3 0.33 10.4 1.7 1.4 1 1 0 1 1 1 0 TMEM156 protein family Pilin_N PF07790.11 EEA27739.1 - 0.32 11.9 2.7 1 10.3 2.7 1.8 1 1 0 1 1 1 0 Archaeal Type IV pilin, N-terminal RAMP4 PF06624.12 EEA27739.1 - 1.1 9.4 8.7 1.7 8.8 4.3 2.2 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 AMPK1_CBM PF16561.5 EEA27740.1 - 8.4e-20 70.8 0.3 1.6e-19 69.8 0.3 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 EEA27740.1 - 0.00074 19.8 0.1 0.002 18.4 0.1 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 EEA27740.1 - 0.024 15.2 0.2 0.05 14.2 0.2 1.5 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) cNMP_binding PF00027.29 EEA27741.1 - 4.4e-38 129.2 0.0 2.7e-19 69.0 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Methyltransf_23 PF13489.6 EEA27742.1 - 4.6e-19 68.8 0.0 8.8e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA27742.1 - 2.4e-11 44.3 0.1 5.5e-11 43.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA27742.1 - 2.7e-08 34.4 0.0 6.5e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA27742.1 - 5.5e-07 30.2 0.0 1.1e-06 29.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA27742.1 - 1.5e-06 28.1 0.0 0.022 14.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 EEA27742.1 - 0.00052 19.6 0.0 0.00083 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EEA27742.1 - 0.0029 17.0 0.0 0.012 14.9 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EEA27742.1 - 0.0043 16.5 0.0 0.014 14.9 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_16 PF10294.9 EEA27742.1 - 0.031 14.0 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase FtsJ PF01728.19 EEA27742.1 - 0.11 12.7 0.0 0.26 11.4 0.0 1.7 1 1 0 1 1 1 0 FtsJ-like methyltransferase p450 PF00067.22 EEA27743.1 - 4.1e-49 167.6 0.0 6e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 2OG-FeII_Oxy_3 PF13640.6 EEA27744.1 - 2e-10 41.4 0.0 3.4e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Forkhead PF00250.18 EEA27745.1 - 5.5e-18 65.0 0.0 1.1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EEA27745.1 - 3.2e-05 24.2 0.0 6.4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain Snf7 PF03357.21 EEA27746.1 - 2.9e-36 124.6 23.2 2.9e-36 124.6 23.2 2.0 1 1 1 2 2 2 1 Snf7 ATP-synt_ab_C PF00306.27 EEA27746.1 - 0.071 13.4 8.8 0.095 13.0 7.3 1.9 1 1 1 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain MtrB PF05440.12 EEA27746.1 - 0.13 12.7 0.3 28 5.2 0.0 2.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF3138 PF11336.8 EEA27746.1 - 0.16 10.6 9.4 0.18 10.4 3.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Ten1 PF12658.7 EEA27747.1 - 1.7e-39 134.5 0.0 1.9e-39 134.3 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.6 EEA27747.1 - 0.0011 18.6 0.0 0.0017 18.0 0.0 1.3 1 1 0 1 1 1 1 Telomere-capping, CST complex subunit MFS_1 PF07690.16 EEA27748.1 - 2.3e-36 125.4 40.7 2.9e-36 125.1 34.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA27748.1 - 1.6e-07 30.2 5.2 1.6e-07 30.2 5.2 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PNTB PF02233.16 EEA27748.1 - 6.6 5.5 10.7 0.13 11.2 0.7 2.1 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit MFS_1 PF07690.16 EEA27749.1 - 1.1e-29 103.5 33.6 5.5e-28 97.9 32.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA27749.1 - 0.00024 19.7 2.6 0.00024 19.7 2.6 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Gal_mutarotas_2 PF13802.6 EEA27749.1 - 0.14 12.5 0.2 0.56 10.6 0.0 2.1 2 0 0 2 2 2 0 Galactose mutarotase-like PNTB PF02233.16 EEA27749.1 - 1.2 8.0 7.8 0.071 12.0 0.8 1.9 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit BCAS2 PF05700.11 EEA27750.1 - 3.1e-67 226.3 2.6 3.5e-67 226.1 2.6 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Sld3_N PF18523.1 EEA27750.1 - 0.031 14.4 0.2 0.055 13.6 0.2 1.4 1 0 0 1 1 1 0 Sld3 N-terminal domain RPA_interact_N PF14766.6 EEA27750.1 - 3.3 7.4 5.2 5.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Replication protein A interacting N-terminal Zn_clus PF00172.18 EEA27751.1 - 1.4e-09 37.9 6.1 4.9e-09 36.2 5.9 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA27751.1 - 4.4e-07 29.0 0.2 8.1e-07 28.2 0.1 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Urb2 PF10441.9 EEA27751.1 - 0.0072 16.3 0.2 0.11 12.4 0.0 2.2 2 0 0 2 2 2 1 Urb2/Npa2 family FecCD PF01032.18 EEA27751.1 - 0.017 14.1 0.1 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 FecCD transport family Ceramidase_alk PF04734.13 EEA27752.1 - 2.6e-211 702.6 0.0 3.1e-211 702.4 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EEA27752.1 - 9e-58 194.8 0.0 1.4e-57 194.2 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Zn_clus PF00172.18 EEA27754.1 - 9.5e-09 35.2 8.8 2.1e-08 34.2 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EI24 PF07264.11 EEA27755.1 - 3.7e-17 63.1 13.9 5.3e-17 62.6 13.9 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DC_STAMP PF07782.13 EEA27755.1 - 0.45 10.3 2.3 1.9 8.3 0.0 2.1 2 0 0 2 2 2 0 DC-STAMP-like protein EI24 PF07264.11 EEA27756.1 - 3.1e-11 43.9 8.7 3.9e-11 43.5 8.7 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) HAD_2 PF13419.6 EEA27757.1 - 3.8e-13 49.9 0.0 6.9e-13 49.1 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA27757.1 - 5.3e-07 30.1 0.0 1.4e-06 28.8 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA27757.1 - 0.00049 20.1 0.0 0.00077 19.5 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like GTP_EFTU PF00009.27 EEA27760.1 - 5.2e-34 117.5 2.4 1.9e-32 112.4 2.4 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EEA27760.1 - 1.2e-28 99.3 0.4 3.3e-28 97.9 0.4 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EEA27760.1 - 2.3e-10 40.5 0.1 5.9e-10 39.2 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 EEA27760.1 - 3.6e-10 39.5 0.0 9.9e-10 38.1 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU_D2 PF03144.25 EEA27760.1 - 7e-06 26.3 6.8 0.069 13.5 0.2 3.8 3 0 0 3 3 3 2 Elongation factor Tu domain 2 SRPRB PF09439.10 EEA27760.1 - 0.00029 20.3 0.1 0.00089 18.7 0.1 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EEA27760.1 - 0.0012 18.8 2.0 0.17 11.8 0.1 2.6 1 1 1 2 2 2 2 RsgA GTPase Arf PF00025.21 EEA27760.1 - 0.0021 17.6 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU_D4 PF14578.6 EEA27760.1 - 0.04 13.8 2.6 1 9.3 0.2 2.9 3 0 0 3 3 3 0 Elongation factor Tu domain 4 FeoB_N PF02421.18 EEA27760.1 - 0.044 13.3 0.3 0.18 11.3 0.3 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Ras PF00071.22 EEA27760.1 - 0.13 11.8 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Ras family Biotin_lipoyl_2 PF13533.6 EEA27760.1 - 0.41 10.5 2.1 0.8 9.6 0.3 2.3 2 0 0 2 2 2 0 Biotin-lipoyl like PDDEXK_2 PF12784.7 EEA27760.1 - 9.3 5.7 8.4 15 5.0 8.4 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease family transposase Mito_carr PF00153.27 EEA27761.1 - 1.2e-60 201.5 1.9 1.6e-19 69.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_31 PF01055.26 EEA27762.1 - 2.2e-90 304.0 0.0 2.8e-90 303.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EEA27762.1 - 2.5e-10 40.5 0.0 7e-10 39.1 0.0 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like Ribosomal_S2 PF00318.20 EEA27763.1 - 2.1e-70 236.3 0.0 4.2e-70 235.3 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S2 DUF4908 PF16252.5 EEA27763.1 - 0.021 14.3 0.8 0.64 9.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4908) PEHE PF15275.6 EEA27763.1 - 1.4 9.6 4.1 1.1 9.8 0.3 2.2 1 1 1 2 2 2 0 PEHE domain Med3 PF11593.8 EEA27763.1 - 1.5 7.9 8.9 2.1 7.4 8.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Dicty_REP PF05086.12 EEA27763.1 - 2.7 5.8 6.1 3.5 5.5 6.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EEA27763.1 - 6.4 6.8 10.0 14 5.7 10.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ribosomal_S2 PF00318.20 EEA27764.1 - 1e-70 237.3 0.0 1.8e-70 236.5 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein S2 Rick_17kDa_Anti PF05433.15 EEA27765.1 - 1.9e-05 24.4 14.5 1.9e-05 24.4 14.5 1.8 2 0 0 2 2 2 1 Glycine zipper 2TM domain adh_short_C2 PF13561.6 EEA27766.1 - 2.5e-51 174.5 0.4 4e-51 173.8 0.4 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA27766.1 - 3.1e-36 124.7 3.9 1.2e-35 122.8 3.9 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA27766.1 - 9.4e-11 41.9 1.1 2.5e-10 40.6 1.1 1.6 1 1 0 1 1 1 1 KR domain Methyltransf_25 PF13649.6 EEA27766.1 - 0.011 16.5 0.0 0.02 15.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.18 EEA27766.1 - 0.098 12.5 0.2 0.14 12.1 0.2 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SURF6 PF04935.12 EEA27767.1 - 7e-53 179.4 31.0 7e-53 179.4 31.0 3.7 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 EEA27767.1 - 4.7e-16 59.1 1.5 4.7e-16 59.1 1.5 7.5 5 2 1 6 6 6 1 60S ribosome biogenesis protein Rrp14 FUSC PF04632.12 EEA27767.1 - 1 7.8 2.8 2.3 6.7 2.8 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fer4 PF00037.27 EEA27768.1 - 1e-13 50.5 17.0 3.6e-08 32.9 4.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EEA27768.1 - 5e-13 49.4 10.5 7.6e-13 48.8 10.5 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EEA27768.1 - 1.4e-10 42.0 7.7 1.9e-05 25.5 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EEA27768.1 - 3.6e-10 39.8 21.7 3.4e-07 30.3 12.4 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EEA27768.1 - 6.4e-10 39.0 21.0 6.2e-08 32.7 11.0 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EEA27768.1 - 1.8e-09 37.6 5.3 0.0002 21.4 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EEA27768.1 - 4.1e-07 30.4 19.4 0.00015 22.1 11.1 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EEA27768.1 - 1.7e-06 27.8 17.5 0.00039 20.4 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EEA27768.1 - 5.3e-06 26.2 12.1 0.01 15.9 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EEA27768.1 - 2.3e-05 24.5 11.5 0.00029 21.1 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EEA27768.1 - 0.00015 22.2 12.3 0.024 15.1 2.0 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EEA27768.1 - 0.012 15.9 6.1 0.35 11.1 0.2 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_13 PF13370.6 EEA27768.1 - 0.044 14.3 15.2 0.73 10.4 4.3 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EEA27768.1 - 0.053 13.7 9.2 1.2 9.3 1.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EEA27768.1 - 0.067 14.2 15.7 0.12 13.4 3.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 EEA27768.1 - 0.13 12.5 6.0 0.54 10.4 0.6 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 EEA27768.1 - 0.39 11.6 11.5 3.4 8.6 2.3 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain PP-binding PF00550.25 EEA27769.1 - 2.1e-10 40.8 0.1 2.8e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EEA27769.1 - 2.1e-05 24.6 0.1 2.8e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Acyl-carrier GPP34 PF05719.11 EEA27770.1 - 2.9e-64 216.8 0.1 3.8e-64 216.5 0.1 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) ADH_zinc_N_2 PF13602.6 EEA27771.1 - 4.5e-10 40.7 0.0 7.4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EEA27771.1 - 6.3e-05 23.0 0.3 0.00015 21.7 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2183 PF09949.9 EEA27772.1 - 4.7e-32 110.3 0.2 8.6e-32 109.4 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) HMMR_N PF15905.5 EEA27773.1 - 0.011 15.2 3.3 0.019 14.4 3.3 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal FPP PF05911.11 EEA27773.1 - 0.02 13.1 5.2 0.033 12.4 5.2 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Sipho_Gp157 PF05565.11 EEA27773.1 - 0.036 14.1 1.6 0.058 13.4 1.6 1.3 1 0 0 1 1 1 0 Siphovirus Gp157 APG6_N PF17675.1 EEA27773.1 - 0.043 14.3 4.3 0.11 13.1 4.3 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region KLRAQ PF10205.9 EEA27773.1 - 0.046 13.9 0.2 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein TSC22 PF01166.18 EEA27773.1 - 0.079 13.3 4.1 1.7 9.0 0.4 2.8 2 0 0 2 2 2 0 TSC-22/dip/bun family DivIC PF04977.15 EEA27773.1 - 0.14 12.0 3.0 0.27 11.0 0.1 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF3450 PF11932.8 EEA27773.1 - 0.2 10.9 2.8 0.75 9.1 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) bZIP_2 PF07716.15 EEA27773.1 - 1.4 9.0 6.4 11 6.2 0.2 2.5 2 0 0 2 2 2 0 Basic region leucine zipper CBS PF00571.28 EEA27775.1 - 1.5e-20 73.3 4.1 2.1e-08 34.5 0.0 5.2 5 0 0 5 5 5 4 CBS domain DDE_3 PF13358.6 EEA27777.1 - 7.3e-12 45.3 0.2 2.1e-11 43.8 0.2 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA27777.1 - 6.3e-10 39.2 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA27777.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA27777.1 - 0.0077 16.2 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA27777.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA27777.1 - 0.0093 16.4 0.1 13 6.3 0.0 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA27777.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA27777.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA27777.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA27777.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA27777.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 Alpha_adaptinC2 PF02883.20 EEA27779.1 - 1.7e-22 79.8 0.1 3.3e-22 78.9 0.1 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 EEA27779.1 - 3.7e-20 72.0 0.4 3.7e-20 72.0 0.4 1.8 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 EEA27779.1 - 2.4e-09 36.7 0.0 1.8e-06 27.5 0.0 2.7 2 0 0 2 2 2 2 GGA N-GAT domain DUF5344 PF17279.2 EEA27779.1 - 0.034 14.7 1.4 0.061 13.9 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DUF349 PF03993.12 EEA27779.1 - 1.1 9.6 4.1 0.69 10.2 0.1 2.5 1 1 2 3 3 3 0 Domain of Unknown Function (DUF349) Alpha_adaptinC2 PF02883.20 EEA27780.1 - 1.7e-22 79.8 0.1 3.3e-22 78.9 0.1 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 EEA27780.1 - 3.7e-20 72.0 0.4 3.7e-20 72.0 0.4 1.8 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 EEA27780.1 - 2.4e-09 36.7 0.0 1.8e-06 27.5 0.0 2.7 2 0 0 2 2 2 2 GGA N-GAT domain DUF5344 PF17279.2 EEA27780.1 - 0.034 14.7 1.4 0.061 13.9 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DUF349 PF03993.12 EEA27780.1 - 1.1 9.6 4.1 0.69 10.2 0.1 2.5 1 1 2 3 3 3 0 Domain of Unknown Function (DUF349) Alpha_adaptinC2 PF02883.20 EEA27781.1 - 1.8e-22 79.7 0.1 3.5e-22 78.8 0.1 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 EEA27781.1 - 3.9e-20 72.0 0.4 3.9e-20 72.0 0.4 1.8 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 EEA27781.1 - 2.6e-09 36.5 0.0 1.9e-06 27.4 0.0 2.7 2 0 0 2 2 2 2 GGA N-GAT domain DUF5344 PF17279.2 EEA27781.1 - 0.015 15.9 0.1 0.064 13.8 0.1 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5344) DUF349 PF03993.12 EEA27781.1 - 1 9.7 3.8 0.73 10.2 0.1 2.5 1 1 2 3 3 3 0 Domain of Unknown Function (DUF349) GAT PF03127.14 EEA27782.1 - 3.1e-20 72.2 0.4 3.1e-20 72.2 0.4 1.8 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 EEA27782.1 - 1.8e-09 37.1 0.0 1.6e-06 27.6 0.0 2.8 2 0 0 2 2 2 2 GGA N-GAT domain Alpha_adaptinC2 PF02883.20 EEA27782.1 - 8.2e-08 32.5 0.0 1.7e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain DUF5344 PF17279.2 EEA27782.1 - 0.037 14.6 1.5 0.053 14.1 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DUF349 PF03993.12 EEA27782.1 - 1.7 9.0 5.1 0.75 10.1 0.6 2.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) Ribo_biogen_C PF04034.13 EEA27783.1 - 4.1e-52 175.2 0.0 5.9e-52 174.7 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EEA27783.1 - 2.4e-11 43.3 0.3 2.4e-11 43.3 0.3 1.6 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI BUD22 PF09073.10 EEA27783.1 - 0.1 11.9 26.6 0.15 11.4 26.6 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EEA27783.1 - 0.17 10.1 13.6 0.23 9.7 13.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 EEA27783.1 - 2.9 7.4 19.0 4.1 6.9 19.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_C14 PF00656.22 EEA27784.1 - 2.8e-63 214.2 0.0 3.6e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 EEA27784.1 - 0.23 11.4 0.3 0.76 9.7 0.0 2.0 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain Cpn60_TCP1 PF00118.24 EEA27785.1 - 8.5e-154 512.8 2.7 9.7e-154 512.6 2.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Beta_helix_2 PF18835.1 EEA27785.1 - 0.099 12.4 0.1 1.3 8.8 0.2 2.5 2 0 0 2 2 2 0 Beta helix repeat of Inulin fructotransferase zf-H2C2 PF09337.10 EEA27786.1 - 2.4e-15 56.5 1.1 5.5e-15 55.3 1.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EEA27786.1 - 5.3e-11 42.4 0.7 1.1e-10 41.5 0.2 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 EEA27786.1 - 0.0011 19.1 0.0 0.0021 18.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EEA27786.1 - 0.019 15.6 1.8 0.035 14.8 0.0 2.3 2 1 1 3 3 3 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA27786.1 - 0.17 11.9 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein LANC_like PF05147.13 EEA27787.1 - 3.3e-21 75.3 0.0 2.7e-20 72.3 0.0 2.3 2 1 0 2 2 2 1 Lanthionine synthetase C-like protein F-box-like PF12937.7 EEA27788.1 - 2.7e-06 27.1 0.1 9.1e-06 25.5 0.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EEA27788.1 - 0.0081 16.6 6.0 2.5 8.7 0.0 4.8 4 1 1 5 5 5 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EEA27788.1 - 0.012 15.6 5.5 0.98 9.6 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich repeat F-box PF00646.33 EEA27788.1 - 0.1 12.5 3.5 0.11 12.4 0.0 2.8 4 0 0 4 4 4 0 F-box domain LRR_1 PF00560.33 EEA27788.1 - 0.11 13.1 0.6 57 4.9 0.1 4.0 3 0 0 3 3 3 0 Leucine Rich Repeat Ribosomal_S26e PF01283.19 EEA27789.1 - 9.5e-52 174.0 8.1 1.1e-51 173.8 8.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EEA27789.1 - 0.022 14.7 0.5 0.053 13.5 0.0 1.9 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 EEA27789.1 - 0.065 13.1 0.3 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) Ribosomal_S26e PF01283.19 EEA27790.1 - 2.4e-44 150.2 3.4 2.6e-44 150.0 3.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EEA27790.1 - 0.039 13.9 1.6 0.052 13.5 0.0 1.9 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 EEA27790.1 - 0.07 13.0 0.3 0.11 12.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) CBS PF00571.28 EEA27791.1 - 1.2e-35 121.7 3.4 4.8e-09 36.5 0.0 5.1 5 0 0 5 5 5 4 CBS domain PB1 PF00564.24 EEA27791.1 - 4.2e-10 39.4 0.0 1.3e-09 37.8 0.0 1.9 1 0 0 1 1 1 1 PB1 domain Importin_rep_4 PF18808.1 EEA27792.1 - 2.5e-30 104.6 0.7 2.5e-30 104.6 0.7 4.2 4 1 0 4 4 3 1 Importin repeat Importin_rep_5 PF18816.1 EEA27792.1 - 4.2e-23 81.4 2.5 4.9e-23 81.2 0.4 2.3 2 0 0 2 2 1 1 Importin repeat HEAT_EZ PF13513.6 EEA27792.1 - 3.3e-22 78.6 13.8 7.7e-10 39.1 0.3 8.6 8 1 1 9 9 8 3 HEAT-like repeat Importin_rep_6 PF18829.1 EEA27792.1 - 2.8e-16 59.6 3.4 3.8e-15 55.9 1.0 2.9 2 0 0 2 2 2 1 Importin repeat 6 HEAT_2 PF13646.6 EEA27792.1 - 9.4e-16 58.0 12.7 0.00025 21.4 0.0 8.8 6 2 5 11 11 9 3 HEAT repeats HEAT PF02985.22 EEA27792.1 - 1.2e-15 56.3 15.0 0.0014 18.7 0.0 11.7 14 0 0 14 14 10 3 HEAT repeat MMS19_C PF12460.8 EEA27792.1 - 2.1e-11 43.6 7.0 2.9e-06 26.7 0.2 6.1 5 1 1 6 6 6 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 EEA27792.1 - 1.5e-10 41.5 0.2 0.0059 17.2 0.0 6.9 6 1 2 8 8 6 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EEA27792.1 - 2.2e-07 31.1 2.3 0.062 13.3 0.1 5.5 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EEA27792.1 - 4.5e-07 29.9 1.3 0.026 14.4 0.0 6.1 5 2 1 6 6 6 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 EEA27792.1 - 3e-06 27.0 2.0 0.14 11.7 0.2 6.7 7 2 3 10 10 10 1 CLASP N terminal RIX1 PF08167.12 EEA27792.1 - 1.8e-05 24.6 0.2 0.011 15.5 0.1 4.1 3 1 1 4 4 3 1 rRNA processing/ribosome biogenesis DUF4042 PF13251.6 EEA27792.1 - 3e-05 23.8 0.6 11 5.7 0.0 5.8 7 0 0 7 7 7 0 Domain of unknown function (DUF4042) Arm PF00514.23 EEA27792.1 - 8.3e-05 22.5 1.5 4.4 7.5 0.0 5.2 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EEA27792.1 - 0.00037 20.7 1.6 0.37 11.0 0.5 5.2 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 TFCD_C PF12612.8 EEA27792.1 - 0.00042 20.2 0.2 0.66 9.8 0.1 3.0 2 0 0 2 2 2 2 Tubulin folding cofactor D C terminal IBN_N PF03810.19 EEA27792.1 - 0.00053 19.8 0.1 0.023 14.6 0.0 3.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain DNA_alkylation PF08713.11 EEA27792.1 - 0.0023 17.7 0.1 0.012 15.3 0.0 2.3 2 0 0 2 2 1 1 DNA alkylation repair enzyme MIF4G_like_2 PF09090.11 EEA27792.1 - 0.0042 16.6 1.2 0.02 14.4 0.1 2.3 2 0 0 2 2 2 1 MIF4G like RdRP_3 PF00998.23 EEA27792.1 - 0.01 14.5 0.0 0.019 13.7 0.0 1.3 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase V-ATPase_H_N PF03224.14 EEA27792.1 - 0.021 14.1 7.3 0.047 13.0 0.2 3.7 3 1 0 3 3 3 0 V-ATPase subunit H Telomere_reg-2 PF10193.9 EEA27792.1 - 0.041 14.3 10.1 0.16 12.4 1.8 4.3 3 3 1 4 4 4 0 Telomere length regulation protein DUF3361 PF11841.8 EEA27792.1 - 0.062 13.2 5.0 0.24 11.3 0.1 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF3361) ROS_MUCR PF05443.11 EEA27792.1 - 0.089 12.8 0.4 0.26 11.4 0.4 1.7 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein Ribonuc_2-5A PF06479.12 EEA27792.1 - 0.096 12.9 0.0 0.49 10.6 0.0 2.2 2 0 0 2 2 1 0 Ribonuclease 2-5A DALR_1 PF05746.15 EEA27792.1 - 0.92 9.7 10.6 1.6 9.0 1.6 4.3 4 1 0 4 4 4 0 DALR anticodon binding domain YBD PF17725.1 EEA27793.1 - 2.5e-06 27.5 0.0 0.002 18.0 0.0 2.3 2 0 0 2 2 2 2 YAP binding domain NmrA PF05368.13 EEA27794.1 - 4.9e-25 88.4 0.0 6.3e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA27794.1 - 1.4e-11 44.7 0.0 2.9e-11 43.6 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EEA27794.1 - 0.0001 22.7 0.0 0.00025 21.5 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EEA27794.1 - 0.0003 21.1 0.0 0.00059 20.1 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 EEA27794.1 - 0.00036 19.6 0.0 0.00068 18.7 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 EEA27794.1 - 0.00064 19.7 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA27794.1 - 0.0036 16.5 0.0 0.0055 15.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA27794.1 - 0.0085 15.6 0.0 0.018 14.5 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Fe-ADH PF00465.19 EEA27795.1 - 3e-68 230.3 0.0 3.6e-68 230.0 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EEA27795.1 - 2.9e-11 43.6 0.1 0.00017 21.4 0.1 2.1 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Aconitase PF00330.20 EEA27796.1 - 1.1e-145 486.1 0.0 1.5e-145 485.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EEA27796.1 - 3.9e-40 137.2 0.0 6.1e-40 136.6 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF4267 PF14087.6 EEA27797.1 - 1.4e-23 83.1 2.4 1.8e-23 82.8 2.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) Tetraspanin PF00335.20 EEA27797.1 - 0.09 12.5 1.9 0.085 12.6 0.8 1.5 1 1 1 2 2 2 0 Tetraspanin family ABC2_membrane_5 PF13346.6 EEA27797.1 - 0.13 11.8 4.6 0.31 10.6 4.6 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF2408 PF10303.9 EEA27798.1 - 3.3e-44 150.7 5.8 6.2e-28 98.0 0.9 4.8 3 2 1 4 4 4 4 Protein of unknown function (DUF2408) Spc7 PF08317.11 EEA27798.1 - 0.012 14.6 0.4 0.012 14.6 0.4 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein IFT57 PF10498.9 EEA27798.1 - 0.015 14.3 0.9 0.027 13.4 0.3 1.8 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 EzrA PF06160.12 EEA27798.1 - 0.043 12.0 0.5 0.082 11.1 0.4 1.5 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA PhaP_Bmeg PF09602.10 EEA27798.1 - 0.079 12.9 0.5 0.63 10.0 0.1 2.3 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF4201 PF13870.6 EEA27798.1 - 0.33 10.7 4.1 0.64 9.7 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) HR1 PF02185.16 EEA27798.1 - 7.8 6.7 6.9 1.5 9.0 0.4 2.8 3 0 0 3 3 3 0 Hr1 repeat Ribosomal_60s PF00428.19 EEA27799.1 - 6.9e-28 97.1 10.0 8.3e-28 96.8 10.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 EEA27799.1 - 0.22 9.9 2.2 0.28 9.6 2.2 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3824 PF12868.7 EEA27799.1 - 0.48 11.1 5.5 0.65 10.6 5.5 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) zf-H2C2_2 PF13465.6 EEA27800.1 - 5.3e-08 32.9 16.7 2.5e-07 30.8 4.0 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EEA27800.1 - 1.6e-07 31.4 16.0 0.0014 19.0 4.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type Fungal_trans PF04082.18 EEA27800.1 - 1.3e-06 27.7 0.3 2.1e-06 27.0 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 EEA27800.1 - 5.3e-06 26.8 14.2 0.014 16.2 3.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EEA27800.1 - 0.0022 17.7 4.3 0.11 12.2 0.6 2.6 2 0 0 2 2 2 2 zinc-finger C2H2-type FYVE PF01363.21 EEA27800.1 - 0.0037 17.4 1.4 0.011 15.8 1.4 1.8 1 0 0 1 1 1 1 FYVE zinc finger zf-C2H2_6 PF13912.6 EEA27800.1 - 0.019 14.9 11.4 0.023 14.7 1.6 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EEA27800.1 - 0.044 13.4 3.7 0.18 11.5 0.2 2.4 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_jaz PF12171.8 EEA27800.1 - 0.29 11.5 3.8 6.6 7.1 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EEA27800.1 - 0.34 11.1 3.5 0.76 9.9 3.5 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 EEA27800.1 - 0.8 9.7 7.7 0.36 10.8 0.2 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DUF3405 PF11885.8 EEA27801.1 - 0.019 13.6 0.1 0.026 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) DUF4293 PF14126.6 EEA27801.1 - 0.15 12.3 0.5 0.44 10.8 0.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) NAD_binding_10 PF13460.6 EEA27802.1 - 8.9e-13 48.5 0.0 3e-10 40.3 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding Epimerase PF01370.21 EEA27802.1 - 1.2e-05 25.0 0.0 1.8e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA27802.1 - 0.004 16.6 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase PNP_UDP_1 PF01048.20 EEA27802.1 - 0.031 13.5 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphorylase superfamily Hpr_kinase_C PF07475.12 EEA27802.1 - 0.042 13.4 0.1 0.08 12.5 0.1 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain NAD_binding_2 PF03446.15 EEA27802.1 - 0.18 11.9 0.0 1.5 9.0 0.0 2.1 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_2 PF03446.15 EEA27803.1 - 9.9e-27 94.0 0.5 9.4e-20 71.4 0.0 2.4 1 1 1 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA27803.1 - 1.2e-22 80.5 0.0 2.1e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Abhydrolase_1 PF00561.20 EEA27803.1 - 2.1e-19 70.2 0.0 1.1e-17 64.6 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA27803.1 - 2.1e-10 41.6 0.9 4.4e-10 40.5 0.9 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA27803.1 - 2.4e-07 30.3 0.0 7.2e-06 25.4 0.0 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 EEA27803.1 - 8.6e-05 22.6 0.0 0.00029 20.9 0.0 1.8 1 0 0 1 1 1 1 TAP-like protein Ndr PF03096.14 EEA27803.1 - 0.15 10.7 0.0 0.31 9.7 0.0 1.4 1 0 0 1 1 1 0 Ndr family Lactamase_B PF00753.27 EEA27804.1 - 1.7e-07 31.4 0.2 3.4e-07 30.5 0.2 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA27804.1 - 0.0079 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain NAD_binding_2 PF03446.15 EEA27805.1 - 1.2e-27 97.0 0.0 1.8e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EEA27805.1 - 1.3e-19 70.6 0.1 2.2e-19 69.9 0.1 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EEA27805.1 - 3.3e-05 24.4 0.1 9.7e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent FAD_binding_3 PF01494.19 EEA27806.1 - 1.6e-39 136.2 0.0 3.1e-39 135.2 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA27806.1 - 7.3e-05 22.9 0.1 0.0002 21.5 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA27806.1 - 9.7e-05 22.1 0.0 0.069 12.7 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA27806.1 - 0.00014 20.7 0.6 0.00044 19.1 0.0 2.0 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox PF00070.27 EEA27806.1 - 0.00026 21.5 0.0 0.47 11.0 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA27806.1 - 0.0019 17.5 0.0 0.0048 16.2 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA27806.1 - 0.0037 16.4 0.1 0.0055 15.8 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EEA27806.1 - 0.0043 16.3 0.2 0.0067 15.7 0.2 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 EEA27806.1 - 0.0095 15.3 0.2 0.055 12.8 0.2 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA27806.1 - 0.072 12.2 0.4 0.13 11.3 0.3 1.5 1 1 1 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EEA27806.1 - 0.074 12.3 0.1 0.17 11.1 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA27806.1 - 0.18 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A p450 PF00067.22 EEA27807.1 - 2.5e-71 240.8 0.0 3.1e-71 240.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_67N PF03648.14 EEA27807.1 - 0.16 12.2 0.1 6.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus PQ-loop PF04193.14 EEA27808.1 - 3e-40 135.8 4.4 1.9e-20 72.3 0.1 2.8 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EEA27808.1 - 0.054 14.3 0.2 2.8 8.7 0.0 2.6 2 1 0 2 2 2 0 ER lumen protein retaining receptor Tcf25 PF04910.14 EEA27809.1 - 6.6e-79 265.5 0.3 9.6e-79 265.0 0.3 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_12 PF13424.6 EEA27809.1 - 0.00015 21.9 0.2 0.07 13.4 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA27809.1 - 0.059 13.5 0.6 0.5 10.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA27809.1 - 1.4 9.9 6.2 3.1 8.9 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Nop53 PF07767.11 EEA27809.1 - 2.2 7.6 19.1 3.5 6.9 19.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Herpes_DNAp_acc PF04929.12 EEA27809.1 - 5 6.0 8.1 7.6 5.4 8.1 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor PP2C PF00481.21 EEA27810.1 - 8.1e-42 143.6 0.0 1.9e-41 142.4 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EEA27810.1 - 0.00014 21.5 0.0 0.00027 20.6 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EEA27810.1 - 0.00077 19.4 0.0 2.8 7.8 0.0 3.0 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EEA27811.1 - 6.8e-42 143.9 0.0 1.7e-41 142.6 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EEA27811.1 - 0.00012 21.8 0.0 0.00024 20.8 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EEA27811.1 - 0.0025 17.8 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) 60KD_IMP PF02096.20 EEA27812.1 - 1.2e-13 51.3 0.2 2.7e-13 50.2 0.2 1.5 1 1 0 1 1 1 1 60Kd inner membrane protein ALG11_N PF15924.5 EEA27813.1 - 2e-83 279.6 0.1 2.7e-83 279.1 0.1 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EEA27813.1 - 7.9e-19 67.8 0.0 2.2e-18 66.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA27813.1 - 4.1e-08 33.7 0.0 8.7e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 AAA_5 PF07728.14 EEA27813.1 - 0.011 15.7 0.0 0.029 14.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Glyco_transf_4 PF13439.6 EEA27813.1 - 0.066 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 zf-C2H2 PF00096.26 EEA27814.1 - 6.9e-13 48.3 11.9 2.6e-06 27.6 2.3 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA27814.1 - 2.6e-12 46.6 9.0 2e-07 31.1 0.2 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA27814.1 - 1.8e-08 34.5 10.2 0.00082 20.0 1.4 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EEA27814.1 - 4.3e-08 33.0 5.2 0.00051 20.0 0.3 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA27814.1 - 1e-05 25.7 0.6 0.37 11.1 0.2 4.0 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EEA27814.1 - 3.5e-05 24.0 1.0 0.014 15.8 0.3 3.4 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EEA27814.1 - 0.012 15.4 4.2 1.2 9.0 0.5 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-Di19 PF05605.12 EEA27814.1 - 0.085 13.2 1.4 0.21 11.9 1.4 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding SUIM_assoc PF16619.5 EEA27814.1 - 0.11 12.5 13.9 2.9 8.0 0.6 3.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-C2HE PF16278.5 EEA27814.1 - 0.15 12.5 1.9 6.4 7.3 0.3 2.8 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_recom PF13408.6 EEA27814.1 - 0.3 11.6 0.8 0.76 10.3 0.8 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain LIM PF00412.22 EEA27814.1 - 0.36 11.1 2.7 17 5.7 2.8 2.4 1 1 1 2 2 2 0 LIM domain zf-BED PF02892.15 EEA27814.1 - 1.1 9.4 3.1 30 4.8 3.1 2.4 1 1 0 1 1 1 0 BED zinc finger FYVE PF01363.21 EEA27814.1 - 2.1 8.6 4.5 4.5 7.5 4.5 1.6 1 0 0 1 1 1 0 FYVE zinc finger C5HCH PF17982.1 EEA27814.1 - 3.3 7.9 6.0 16 5.8 0.4 2.6 1 1 1 2 2 2 0 NSD Cys-His rich domain Pkinase PF00069.25 EEA27815.1 - 1.1e-50 172.4 0.1 3.6e-33 115.1 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27815.1 - 1.8e-24 86.4 0.1 3.1e-23 82.4 0.1 2.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA27815.1 - 3.1e-05 23.4 0.0 0.00011 21.7 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA27815.1 - 4.5e-05 22.4 0.4 0.00014 20.8 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EEA27815.1 - 0.0017 18.3 0.1 0.0077 16.2 0.1 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kelch_5 PF13854.6 EEA27816.1 - 5.7e-05 23.0 0.5 0.0016 18.4 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 EEA27816.1 - 8.4e-05 22.7 6.3 1.6 9.2 0.1 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EEA27816.1 - 0.0004 20.3 1.5 0.8 9.8 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EEA27816.1 - 0.0024 17.8 0.1 0.12 12.4 0.0 3.2 2 0 0 2 2 2 1 Kelch motif SKG6 PF08693.10 EEA27816.1 - 0.03 13.7 0.2 0.06 12.8 0.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kelch_3 PF13415.6 EEA27816.1 - 0.084 13.2 14.0 5.5 7.4 0.2 5.4 5 0 0 5 5 5 0 Galactose oxidase, central domain SIN1 PF05422.12 EEA27816.1 - 2.5 8.7 6.9 1.1 9.9 1.8 2.4 2 0 0 2 2 2 0 Stress-activated map kinase interacting protein 1 (SIN1) BPL_LplA_LipB PF03099.19 EEA27817.1 - 5.8e-08 32.7 0.0 1.4e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Chorismate_synt PF01264.21 EEA27818.1 - 3e-139 463.3 0.0 3.5e-139 463.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ima1_N PF09779.9 EEA27819.1 - 2.1e-33 116.0 8.2 2.1e-33 116.0 8.2 2.2 2 0 0 2 2 2 1 Ima1 N-terminal domain Dpy19 PF10034.9 EEA27819.1 - 0.012 13.8 0.0 0.021 13.1 0.0 1.2 1 0 0 1 1 1 0 Q-cell neuroblast polarisation OrfB_Zn_ribbon PF07282.11 EEA27819.1 - 4 7.4 6.7 2.8 7.9 2.7 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DZR PF12773.7 EEA27819.1 - 5.4 7.1 8.6 11 6.1 0.5 2.5 2 1 0 2 2 2 0 Double zinc ribbon AA_permease PF00324.21 EEA27820.1 - 3.4e-117 392.0 38.1 4.2e-117 391.7 38.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EEA27820.1 - 1.7e-37 129.3 39.9 2.2e-37 128.9 39.9 1.2 1 0 0 1 1 1 1 Amino acid permease Alg14 PF08660.11 EEA27821.1 - 2.2e-57 193.8 0.0 3.3e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like adh_short_C2 PF13561.6 EEA27822.1 - 1.1e-48 165.9 0.4 1.3e-48 165.6 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA27822.1 - 2.8e-44 150.9 0.0 3.5e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA27822.1 - 2.6e-10 40.5 0.1 3.6e-10 40.1 0.1 1.1 1 0 0 1 1 1 1 KR domain UDPG_MGDP_dh_C PF03720.15 EEA27822.1 - 0.077 13.4 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Formyl_trans_N PF00551.19 EEA27823.1 - 6.7e-20 71.6 0.0 1.4e-19 70.6 0.0 1.5 1 1 0 1 1 1 1 Formyl transferase WRC PF08879.10 EEA27823.1 - 0.011 15.4 0.5 0.023 14.4 0.5 1.5 1 0 0 1 1 1 0 WRC Formyl_trans_C PF02911.18 EEA27823.1 - 0.026 14.8 0.1 0.079 13.2 0.1 1.8 1 1 0 1 1 1 0 Formyl transferase, C-terminal domain CaATP_NAI PF12515.8 EEA27823.1 - 0.13 11.9 0.3 0.29 10.8 0.3 1.6 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain DUF1712 PF08217.11 EEA27824.1 - 8.4e-19 67.5 0.0 3.4e-16 58.9 0.0 2.5 3 0 0 3 3 3 2 Fungal domain of unknown function (DUF1712) DUF5534 PF17686.1 EEA27824.1 - 0.22 11.7 0.3 0.42 10.8 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5534) Ras PF00071.22 EEA27825.1 - 5.7e-56 188.6 0.0 6.6e-56 188.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA27825.1 - 4.9e-22 78.4 0.0 7.2e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA27825.1 - 9.8e-08 31.6 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA27825.1 - 0.00024 20.7 0.0 0.00062 19.4 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EEA27825.1 - 0.0047 16.4 0.0 0.0063 16.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EEA27825.1 - 0.1 12.0 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region NB-ARC PF00931.22 EEA27825.1 - 0.13 11.4 0.1 1.2 8.3 0.0 2.0 1 1 1 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 EEA27825.1 - 0.17 11.8 0.0 0.62 9.9 0.0 1.9 2 1 0 2 2 2 0 RsgA GTPase KOW PF00467.29 EEA27826.1 - 0.0074 16.2 0.0 0.025 14.5 0.0 1.9 1 0 0 1 1 1 1 KOW motif Rtt106 PF08512.12 EEA27827.1 - 5.8e-33 113.2 0.1 1.1e-32 112.2 0.1 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_18 PF18469.1 EEA27827.1 - 0.061 13.3 0.0 0.37 10.8 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Potyvirid-P3 PF13608.6 EEA27827.1 - 0.072 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein Mpp10 PF04006.12 EEA27827.1 - 1.4 7.2 24.5 0.027 12.9 17.8 1.4 2 0 0 2 2 2 0 Mpp10 protein CCDC53 PF10152.9 EEA27827.1 - 4 7.9 8.3 0.9 9.9 0.3 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Pkinase PF00069.25 EEA27828.1 - 4e-27 95.2 0.0 5e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27828.1 - 1.7e-14 53.8 0.0 2.2e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA27828.1 - 1e-06 27.8 0.1 1.5e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase CAP_N PF01213.19 EEA27828.1 - 0.086 12.3 1.3 0.14 11.6 1.3 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Ank_2 PF12796.7 EEA27829.1 - 6.1e-43 145.3 0.1 5.1e-14 52.6 0.0 5.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA27829.1 - 9.7e-27 90.1 0.0 0.00043 20.5 0.0 9.4 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EEA27829.1 - 2.4e-25 88.3 0.6 1.8e-06 28.1 0.1 7.3 3 2 5 8 8 8 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA27829.1 - 7.8e-25 86.9 0.0 4.9e-08 33.4 0.0 6.8 7 1 1 8 8 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EEA27829.1 - 3.4e-22 77.8 0.3 0.0031 17.9 0.0 9.4 10 0 0 10 10 10 4 Ankyrin repeat NACHT PF05729.12 EEA27829.1 - 7.3e-11 42.3 0.0 2.2e-10 40.7 0.0 1.9 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 EEA27829.1 - 6.1e-05 22.4 0.2 0.00047 19.5 0.2 2.1 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 EEA27829.1 - 0.00085 19.7 0.1 0.0079 16.6 0.0 2.7 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 EEA27829.1 - 0.001 19.4 0.0 0.005 17.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA27829.1 - 0.014 15.9 0.0 56 4.3 0.0 3.7 2 1 1 3 3 3 0 AAA domain TsaE PF02367.17 EEA27829.1 - 0.14 12.2 0.0 0.39 10.7 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 EEA27829.1 - 0.17 12.3 0.3 4.2 7.8 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Nitro_FeMo-Co PF02579.17 EEA27829.1 - 0.78 10.1 3.1 4.3 7.7 0.1 3.1 2 1 0 3 3 3 0 Dinitrogenase iron-molybdenum cofactor RGS PF00615.19 EEA27830.1 - 4.1e-13 49.6 0.0 5.8e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain S36_mt PF10937.8 EEA27831.1 - 1.6e-40 139.2 0.2 1.9e-40 139.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Ribonucleas_3_3 PF14622.6 EEA27832.1 - 1.8e-06 28.1 0.0 1.1e-05 25.5 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EEA27832.1 - 7.8e-06 26.5 0.0 4.1e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease III domain Med18 PF09637.10 EEA27833.1 - 2.7e-55 187.9 0.0 3.1e-55 187.7 0.0 1.0 1 0 0 1 1 1 1 Med18 protein PNK3P PF08645.11 EEA27834.1 - 1.3e-57 194.0 0.1 2.2e-57 193.2 0.1 1.4 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EEA27834.1 - 8.9e-27 94.0 0.0 6.9e-14 52.2 0.0 2.4 1 1 1 2 2 2 2 AAA domain KTI12 PF08433.10 EEA27834.1 - 5.4e-06 26.0 0.5 0.0071 15.8 0.0 2.5 2 1 1 3 3 3 2 Chromatin associated protein KTI12 PNK3P PF08645.11 EEA27835.1 - 1.1e-57 194.3 0.1 1.9e-57 193.5 0.1 1.4 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EEA27835.1 - 4.7e-24 85.2 0.0 4.4e-11 43.1 0.1 2.4 1 1 1 2 2 2 2 AAA domain KTI12 PF08433.10 EEA27835.1 - 0.00026 20.5 1.8 0.15 11.5 0.0 2.5 2 1 1 3 3 3 2 Chromatin associated protein KTI12 AAA_18 PF13238.6 EEA27835.1 - 0.2 12.2 0.1 1.3 9.6 0.1 2.2 2 1 0 2 2 2 0 AAA domain 4HBT_3 PF13622.6 EEA27837.1 - 6.2e-32 111.8 0.2 7.5e-32 111.5 0.2 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily EMP24_GP25L PF01105.24 EEA27839.1 - 3.4e-51 173.8 0.1 3.9e-51 173.6 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2721 PF11026.8 EEA27839.1 - 0.0075 16.2 0.4 0.015 15.2 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2721) SANT_DAMP1_like PF16282.5 EEA27840.1 - 7e-32 109.5 3.6 1.6e-31 108.4 3.6 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 EEA27840.1 - 0.00084 19.3 4.1 0.00084 19.3 4.1 3.3 2 1 1 3 3 3 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-binding PF00249.31 EEA27840.1 - 0.093 12.9 0.0 0.41 10.9 0.0 2.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain Steroid_dh PF02544.16 EEA27842.1 - 4.8e-14 52.6 1.6 2e-07 31.1 0.4 3.3 2 1 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EEA27842.1 - 0.0049 16.4 0.1 0.0098 15.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Ufd2P_core PF10408.9 EEA27843.1 - 1.7e-218 727.3 9.3 2.1e-218 727.0 9.3 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EEA27843.1 - 4.5e-26 90.8 3.8 4.8e-26 90.7 1.1 2.5 2 0 0 2 2 2 1 U-box domain DUF1977 PF09320.11 EEA27844.1 - 1e-30 106.1 0.5 1.6e-30 105.4 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EEA27844.1 - 3e-22 78.5 0.3 5.5e-22 77.7 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain Aim19 PF10315.9 EEA27845.1 - 1.2e-05 25.6 0.3 1.8e-05 25.0 0.3 1.3 1 1 0 1 1 1 1 Altered inheritance of mitochondria protein 19 DUF4536 PF15055.6 EEA27845.1 - 0.0032 17.7 0.1 0.014 15.6 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) CTP_transf_like PF01467.26 EEA27846.1 - 1.3e-05 25.5 0.0 3.2e-05 24.2 0.0 1.9 1 1 0 1 1 1 1 Cytidylyltransferase-like Ydc2-catalyt PF09159.10 EEA27848.1 - 2.4e-87 293.2 0.2 3e-87 292.9 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 SAP PF02037.27 EEA27848.1 - 6.5e-07 29.0 0.1 1.2e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 SAP domain Pox_A22 PF04848.13 EEA27848.1 - 0.012 15.8 0.1 15 5.6 0.0 3.2 3 0 0 3 3 3 0 Poxvirus A22 protein Asp PF00026.23 EEA27849.1 - 6.9e-46 157.1 0.0 8.2e-46 156.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Flg_hook PF02120.16 EEA27851.1 - 0.0065 16.3 0.0 0.015 15.2 0.0 1.7 1 1 0 1 1 1 1 Flagellar hook-length control protein FliK NAD_binding_8 PF13450.6 EEA27852.1 - 1.9e-11 44.0 0.0 2e-10 40.7 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EEA27852.1 - 1.1e-10 41.4 0.0 7.3e-10 38.7 0.0 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EEA27852.1 - 1.7e-08 34.0 0.4 2.7e-08 33.3 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EEA27852.1 - 7.9e-08 32.1 0.3 1.5e-07 31.1 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA27852.1 - 8.8e-07 28.0 0.3 1.4e-06 27.3 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EEA27852.1 - 8.7e-06 25.5 0.4 1.6e-05 24.7 0.4 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA27852.1 - 2.3e-05 24.9 0.1 6e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA27852.1 - 9.2e-05 21.8 0.1 0.00014 21.2 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA27852.1 - 0.00025 20.4 0.1 0.00042 19.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EEA27852.1 - 0.00092 18.6 0.2 0.0014 17.9 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA27852.1 - 0.0017 17.5 0.1 0.0024 17.0 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EEA27852.1 - 0.0033 16.7 0.2 0.0056 16.0 0.2 1.2 1 0 0 1 1 1 1 Thi4 family IlvN PF07991.12 EEA27852.1 - 0.0085 15.7 0.3 0.014 15.0 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lycopene_cycl PF05834.12 EEA27852.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 EEA27852.1 - 0.07 12.8 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Amidohydro_2 PF04909.14 EEA27852.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase Trp_halogenase PF04820.14 EEA27852.1 - 0.24 10.2 0.1 0.34 9.7 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase p450 PF00067.22 EEA27853.1 - 4.6e-44 150.9 0.0 5.9e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EEA27854.1 - 2.4e-38 132.0 57.4 2.4e-38 132.0 57.4 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA27854.1 - 4.5e-09 35.3 26.3 5.6e-09 35.0 26.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.18 EEA27856.1 - 3.2e-08 33.6 9.9 5.6e-08 32.8 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA27856.1 - 2.6e-05 23.2 1.4 5.7e-05 22.1 0.3 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain HEAT_EZ PF13513.6 EEA27856.1 - 0.13 12.8 0.1 16 6.1 0.0 3.4 3 0 0 3 3 3 0 HEAT-like repeat ABC_membrane PF00664.23 EEA27857.1 - 9.5e-77 258.3 45.8 1.6e-42 146.1 15.9 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA27857.1 - 2.2e-58 196.6 0.0 9.9e-28 97.4 0.0 3.3 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EEA27857.1 - 3.3e-14 52.9 4.6 5.2e-05 22.8 2.0 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA27857.1 - 5.5e-08 32.4 0.5 0.0014 18.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA27857.1 - 2.3e-07 31.3 2.3 0.014 15.8 0.3 3.7 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA27857.1 - 5.2e-07 30.0 0.0 0.018 15.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EEA27857.1 - 2.8e-06 27.3 0.0 0.11 12.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EEA27857.1 - 4.6e-06 26.6 0.2 0.015 15.1 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EEA27857.1 - 7e-06 26.1 0.1 0.11 12.3 0.1 3.3 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EEA27857.1 - 1.3e-05 25.6 3.7 0.067 13.6 0.4 4.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EEA27857.1 - 2.1e-05 24.1 0.0 0.23 11.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_30 PF13604.6 EEA27857.1 - 3.7e-05 23.5 0.2 1.3 8.7 0.0 3.7 3 1 0 3 3 3 2 AAA domain SbcCD_C PF13558.6 EEA27857.1 - 0.00031 20.9 3.2 1.9 8.8 0.2 4.0 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EEA27857.1 - 0.00044 20.8 0.0 1.3 9.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EEA27857.1 - 0.00066 20.2 0.0 2.5 8.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 EEA27857.1 - 0.00072 18.5 0.3 0.58 8.9 0.0 2.5 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_5 PF07728.14 EEA27857.1 - 0.001 19.1 0.1 1.3 9.0 0.0 3.4 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EEA27857.1 - 0.0011 18.8 0.5 1.2 8.8 0.0 3.5 4 0 0 4 4 3 1 IstB-like ATP binding protein AAA_33 PF13671.6 EEA27857.1 - 0.0017 18.5 0.1 1.2 9.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EEA27857.1 - 0.0028 17.3 0.0 5 6.7 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EEA27857.1 - 0.0036 17.0 0.0 2.9 7.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 EEA27857.1 - 0.018 14.7 0.0 8 6.0 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Cytidylate_kin PF02224.18 EEA27857.1 - 0.019 14.7 0.0 0.84 9.3 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase ATP-synt_ab PF00006.25 EEA27857.1 - 0.022 14.4 0.0 1.1 8.9 0.0 2.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 EEA27857.1 - 0.022 15.0 0.0 9 6.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 EEA27857.1 - 0.03 14.1 0.0 53 3.5 0.0 3.5 4 0 0 4 4 4 0 DEAD/DEAH box helicase ATP_bind_1 PF03029.17 EEA27857.1 - 0.034 13.9 0.0 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Rad17 PF03215.15 EEA27857.1 - 0.07 13.0 0.0 3.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain APS_kinase PF01583.20 EEA27857.1 - 0.096 12.6 0.2 27 4.6 0.0 3.2 3 0 0 3 3 3 0 Adenylylsulphate kinase Mg_chelatase PF01078.21 EEA27857.1 - 0.12 11.7 0.0 7.1 5.9 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Synapsin_N PF10581.9 EEA27857.1 - 0.2 11.6 0.0 17 5.5 0.0 2.5 2 0 0 2 2 2 0 Synapsin N-terminal Tcp11 PF05794.13 EEA27858.1 - 1.7e-92 310.8 0.9 2.3e-92 310.4 0.9 1.1 1 0 0 1 1 1 1 T-complex protein 11 PemK_toxin PF02452.17 EEA27858.1 - 0.13 12.7 0.4 0.9 10.0 0.0 2.5 2 1 0 2 2 2 0 PemK-like, MazF-like toxin of type II toxin-antitoxin system SOG2 PF10428.9 EEA27859.1 - 4.9e-100 336.1 0.1 2.5e-50 172.2 0.1 4.9 4 1 1 5 5 5 2 RAM signalling pathway protein LRR_8 PF13855.6 EEA27859.1 - 4.7e-13 48.7 1.4 5.2e-06 26.1 0.1 2.8 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EEA27859.1 - 1.2e-10 41.4 2.4 0.00011 22.5 0.1 3.4 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EEA27859.1 - 0.22 12.2 6.0 1.7e+02 3.4 0.0 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 EEA27859.1 - 1.9 8.8 4.4 63 4.0 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeat MRP-S25 PF13741.6 EEA27860.1 - 2.9e-84 282.2 3.8 3.5e-84 282.0 3.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EEA27860.1 - 0.012 15.8 3.3 3 8.1 0.2 2.6 2 1 0 3 3 3 0 Mitochondrial ribosomal protein S23 PPR_2 PF13041.6 EEA27861.1 - 5e-08 33.0 0.1 0.13 12.5 0.0 5.3 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 EEA27861.1 - 4e-05 23.6 0.9 0.19 12.1 0.0 5.1 6 0 0 6 6 6 1 PPR repeat PPR_long PF17177.4 EEA27861.1 - 0.0045 16.4 0.0 0.036 13.4 0.0 2.0 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EEA27861.1 - 0.081 13.0 0.0 47 4.2 0.0 3.8 3 1 1 4 4 4 0 Pentatricopeptide repeat domain PPR_1 PF12854.7 EEA27861.1 - 0.26 11.0 0.8 3.7 7.3 0.0 2.8 3 0 0 3 3 3 0 PPR repeat Helicase_C PF00271.31 EEA27862.1 - 3e-17 63.0 0.0 2.3e-12 47.2 0.0 3.4 3 1 1 4 4 4 2 Helicase conserved C-terminal domain DEAD PF00270.29 EEA27862.1 - 6.3e-17 61.9 0.0 1.6e-15 57.3 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EEA27862.1 - 3e-06 27.9 1.7 8.1e-06 26.5 1.7 1.8 1 0 0 1 1 1 1 RecQ zinc-binding NPP1 PF05630.11 EEA27863.1 - 8.3e-61 205.5 0.0 9.5e-61 205.3 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) KH_1 PF00013.29 EEA27864.1 - 5.7e-10 38.9 0.0 3.4e-07 30.0 0.0 2.6 2 0 0 2 2 2 2 KH domain SUIM_assoc PF16619.5 EEA27864.1 - 0.00093 19.2 0.8 0.00093 19.2 0.8 2.6 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 ALS_ss_C PF10369.9 EEA27865.1 - 8.8e-16 57.9 0.0 4.2e-14 52.5 0.0 2.5 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 EEA27865.1 - 5.6e-12 45.2 0.2 1.2e-11 44.1 0.2 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EEA27865.1 - 7e-08 32.2 0.0 1.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EEA27865.1 - 0.033 14.2 0.0 6.8 6.8 0.0 2.6 2 0 0 2 2 2 0 ACT domain Limkain-b1 PF11608.8 EEA27865.1 - 0.065 13.3 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 Limkain b1 DUF3712 PF12505.8 EEA27866.1 - 2e-09 37.8 0.4 1.4e-06 28.6 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF3712) LEA_2 PF03168.13 EEA27866.1 - 0.00059 20.3 0.5 4 8.0 0.0 4.4 6 0 0 6 6 6 2 Late embryogenesis abundant protein OTCace_N PF02729.21 EEA27867.1 - 9.9e-47 158.7 0.0 1.5e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EEA27867.1 - 1.4e-45 155.2 0.0 2.2e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Bac_rhamnosid PF05592.11 EEA27867.1 - 0.035 14.1 0.0 0.094 12.7 0.0 1.7 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain DUF3984 PF13136.6 EEA27868.1 - 2e-97 326.6 29.5 2.5e-97 326.3 29.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) PBP1_TM PF14812.6 EEA27868.1 - 3.9 7.9 5.7 8.7 6.8 2.3 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Methyltransf_23 PF13489.6 EEA27869.1 - 3.8e-22 78.9 0.0 5.2e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA27869.1 - 2.2e-07 31.5 0.0 7.2e-07 29.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA27869.1 - 0.00016 21.5 0.1 0.0028 17.4 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA27869.1 - 0.00024 21.7 0.0 0.0006 20.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA27869.1 - 0.00043 21.0 0.0 0.0044 17.7 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EEA27869.1 - 0.0039 16.7 0.0 0.0093 15.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EEA27869.1 - 0.053 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 EEA27869.1 - 0.19 11.2 0.0 0.65 9.5 0.0 1.9 3 0 0 3 3 3 0 Putative methyltransferase PrmA PF06325.13 EEA27869.1 - 0.21 11.0 0.0 0.32 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EEA27870.1 - 3.3e-22 79.1 0.0 4.3e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA27870.1 - 1.9e-07 31.7 0.0 6.4e-07 30.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA27870.1 - 0.00013 21.8 0.0 0.0025 17.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA27870.1 - 0.0002 22.0 0.0 0.00053 20.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA27870.1 - 0.00036 21.2 0.0 0.0039 17.9 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EEA27870.1 - 0.0035 16.9 0.0 0.0084 15.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EEA27870.1 - 0.048 13.4 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 EEA27870.1 - 0.16 11.4 0.0 0.59 9.6 0.0 2.0 3 0 0 3 3 3 0 Putative methyltransferase PrmA PF06325.13 EEA27870.1 - 0.19 11.1 0.0 0.29 10.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Cut8 PF08559.10 EEA27871.1 - 3.2e-80 269.2 0.0 3.7e-80 269.0 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein rRNA_proc-arch PF13234.6 EEA27872.1 - 1.5e-92 310.4 0.2 3.3e-92 309.2 0.2 1.7 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 EEA27872.1 - 6.5e-57 191.8 2.9 1.2e-56 190.9 1.7 2.1 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 EEA27872.1 - 2.5e-18 66.5 0.4 7.8e-18 64.8 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA27872.1 - 4.9e-07 30.1 0.0 1.5e-06 28.5 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA27872.1 - 2.6e-05 24.3 0.0 6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EEA27872.1 - 0.0055 15.8 0.0 0.018 14.1 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein ATPase_2 PF01637.18 EEA27872.1 - 0.036 14.0 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EEA27872.1 - 0.14 12.4 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF5388 PF17363.2 EEA27872.1 - 0.32 11.2 3.1 0.52 10.6 0.3 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5388) Cytochrom_B562 PF07361.11 EEA27872.1 - 0.5 11.0 3.7 21 5.8 0.5 4.0 4 0 0 4 4 4 0 Cytochrome b562 COX7C PF02935.16 EEA27873.1 - 3.4e-23 81.7 4.8 4.1e-23 81.4 4.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc COX7C PF02935.16 EEA27874.1 - 1.1e-13 51.2 2.2 1.4e-13 50.9 2.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc IKI3 PF04762.12 EEA27875.1 - 0 1021.6 0.0 0 1021.4 0.0 1.0 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EEA27875.1 - 0.0028 17.9 0.1 10 6.5 0.0 4.9 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_16 PF13432.6 EEA27875.1 - 0.59 10.8 12.8 0.16 12.6 5.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat MDD_C PF18376.1 EEA27876.1 - 3.5e-63 212.7 0.0 5.9e-63 212.0 0.0 1.4 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EEA27876.1 - 4.5e-09 36.4 0.3 1.7e-08 34.5 0.5 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain Cyto_heme_lyase PF01265.17 EEA27877.1 - 2.3e-36 125.9 4.4 3.7e-33 115.4 0.1 3.1 2 2 0 2 2 2 2 Cytochrome c/c1 heme lyase ATP13 PF12921.7 EEA27877.1 - 0.15 12.0 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ATPase expression RCC1 PF00415.18 EEA27878.1 - 6.5e-55 183.6 11.7 7.6e-11 42.5 0.0 8.0 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA27878.1 - 5.6e-32 108.9 35.5 6.2e-07 29.1 0.1 6.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat sCache_3_2 PF17203.4 EEA27878.1 - 0.091 12.9 0.0 2.8 8.1 0.0 2.6 3 0 0 3 3 3 0 Single cache domain 3 Asp PF00026.23 EEA27879.1 - 3.5e-70 236.9 4.7 4.4e-70 236.6 4.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA27879.1 - 5.3e-10 39.8 5.7 1.3e-07 32.0 4.8 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA27879.1 - 8.5e-05 23.1 0.6 0.38 11.4 0.0 2.9 2 0 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EEA27879.1 - 8.8e-05 22.3 0.1 0.0021 17.9 0.0 2.4 1 1 1 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EEA27879.1 - 0.063 13.9 0.2 9.1 6.9 0.0 3.0 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-C2H2 PF00096.26 EEA27880.1 - 0.00051 20.4 22.6 0.022 15.2 1.7 5.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-FCS PF06467.14 EEA27880.1 - 0.031 14.2 3.2 4.1 7.4 0.2 3.0 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-CHCC PF10276.9 EEA27880.1 - 0.047 13.8 4.6 3 8.0 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_jaz PF12171.8 EEA27880.1 - 0.74 10.2 16.9 0.62 10.4 4.1 4.3 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EEA27880.1 - 0.95 10.5 27.4 0.52 11.3 2.0 5.9 5 0 0 5 5 5 0 C2H2-type zinc finger DSPc PF00782.20 EEA27882.1 - 6e-27 94.1 0.0 8.1e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA27882.1 - 0.02 14.5 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Vfa1 PF08432.10 EEA27885.1 - 1.5e-62 211.1 25.8 1.8e-62 210.9 25.8 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 CDC27 PF09507.10 EEA27885.1 - 0.00062 19.3 35.3 0.00072 19.1 35.3 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 RR_TM4-6 PF06459.12 EEA27885.1 - 0.0086 15.9 19.0 0.014 15.3 19.0 1.3 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 DUF262 PF03235.14 EEA27885.1 - 0.012 15.8 11.3 0.013 15.7 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 CDC45 PF02724.14 EEA27885.1 - 0.13 10.5 23.3 0.14 10.4 23.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 EEA27885.1 - 0.15 11.4 17.5 0.19 11.1 17.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF913 PF06025.12 EEA27885.1 - 0.17 10.8 7.2 0.23 10.4 7.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.17 EEA27885.1 - 0.24 11.5 7.9 0.31 11.2 7.9 1.2 1 0 0 1 1 1 0 DDHD domain DUF908 PF06012.12 EEA27885.1 - 0.3 10.5 4.5 0.34 10.3 4.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) NPR3 PF03666.13 EEA27885.1 - 0.52 9.0 21.0 0.65 8.7 21.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PPL5 PF18168.1 EEA27885.1 - 0.55 9.5 15.5 0.86 8.8 15.5 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Mitofilin PF09731.9 EEA27885.1 - 0.67 8.7 24.2 0.83 8.4 24.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SLC12 PF03522.15 EEA27885.1 - 0.94 8.4 17.0 1.1 8.2 17.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 AAA_21 PF13304.6 EEA27885.1 - 1.2 8.9 5.3 1.4 8.6 5.3 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MCM_bind PF09739.9 EEA27885.1 - 1.3 7.4 15.7 1.5 7.2 15.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Neur_chan_memb PF02932.16 EEA27885.1 - 1.4 8.9 7.9 1.6 8.7 7.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TP53IP5 PF15331.6 EEA27885.1 - 2.7 8.1 22.7 3.6 7.7 22.7 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Zip PF02535.22 EEA27885.1 - 3 7.0 12.2 3.6 6.7 12.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EEA27885.1 - 3.4 6.3 17.5 4.1 6.0 17.5 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 EEA27885.1 - 4.7 5.5 5.4 5 5.4 5.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 WDCP PF15390.6 EEA27885.1 - 5.1 5.4 8.4 5.6 5.2 8.4 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family FAM60A PF15396.6 EEA27885.1 - 5.6 6.9 19.9 8.8 6.3 19.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A AAA_11 PF13086.6 EEA27885.1 - 5.8 6.6 17.1 7.4 6.3 17.1 1.2 1 0 0 1 1 1 0 AAA domain DUF2201_N PF13203.6 EEA27885.1 - 6 6.4 11.6 8.2 5.9 11.6 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain TFIIF_alpha PF05793.12 EEA27885.1 - 7.2 5.1 42.0 9.8 4.6 42.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) 4HBT PF03061.22 EEA27886.1 - 0.0044 17.3 0.1 1.2 9.5 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily Ndc1_Nup PF09531.10 EEA27887.1 - 3.7e-192 640.3 1.7 4.2e-192 640.1 1.7 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Syntaxin_2 PF14523.6 EEA27888.1 - 2.2e-26 92.2 4.1 2.2e-26 92.2 4.1 2.5 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EEA27888.1 - 3e-15 55.9 1.3 3e-15 55.9 1.3 1.9 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EEA27888.1 - 6.9e-06 25.9 13.5 1.6e-05 24.7 13.5 1.7 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 EEA27888.1 - 0.011 15.5 1.9 0.02 14.7 0.3 2.2 2 0 0 2 2 2 0 Synaptobrevin DUF883 PF05957.13 EEA27888.1 - 0.028 15.0 0.1 0.028 15.0 0.1 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Nre_C PF04895.12 EEA27888.1 - 0.045 13.7 0.1 0.045 13.7 0.1 2.5 3 0 0 3 3 3 0 Archaeal Nre, C-terminal Type_III_YscX PF09474.10 EEA27888.1 - 0.18 12.1 4.6 2.2 8.6 0.1 2.8 2 1 0 2 2 2 0 Type III secretion system YscX (type_III_YscX) DUF1664 PF07889.12 EEA27888.1 - 1.3 9.1 5.7 16 5.5 0.1 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) SAP PF02037.27 EEA27889.1 - 1e-09 37.9 0.1 1.7e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 SAP domain S-AdoMet_synt_C PF02773.16 EEA27889.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain SAP PF02037.27 EEA27890.1 - 1e-09 37.9 0.1 1.7e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 SAP domain S-AdoMet_synt_C PF02773.16 EEA27890.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain FMN_dh PF01070.18 EEA27891.1 - 8e-112 373.7 0.1 9.7e-112 373.4 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EEA27891.1 - 8.6e-18 64.3 0.0 1.8e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EEA27891.1 - 2.3e-05 23.7 0.0 4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EEA27891.1 - 0.00083 18.7 0.1 0.29 10.4 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 EEA27891.1 - 0.0018 17.4 0.7 0.0033 16.5 0.2 1.7 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EEA27891.1 - 0.033 13.6 0.3 0.075 12.4 0.2 1.5 1 1 1 2 2 2 0 Nitronate monooxygenase TatD_DNase PF01026.21 EEA27892.1 - 2.1e-52 178.0 0.0 2.6e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Aa_trans PF01490.18 EEA27893.1 - 4.3e-78 262.8 32.6 5.4e-78 262.5 32.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1543 PF07566.12 EEA27894.1 - 0.12 12.2 0.2 0.26 11.0 0.2 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1543) Rad52_Rad22 PF04098.15 EEA27895.1 - 2.4e-60 202.9 0.0 3.3e-60 202.5 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein SPX PF03105.19 EEA27895.1 - 2.2 8.1 6.2 3.5 7.5 6.2 1.4 1 0 0 1 1 1 0 SPX domain UBA PF00627.31 EEA27896.1 - 1.1e-07 31.6 0.0 3.2e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain UBX PF00789.20 EEA27896.1 - 2.4e-05 24.5 0.1 7.8e-05 22.8 0.1 2.0 1 0 0 1 1 1 1 UBX domain zf-C2H2_2 PF12756.7 EEA27896.1 - 0.11 12.8 0.5 0.11 12.8 0.5 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EEA27896.1 - 0.17 12.4 0.2 0.33 11.5 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type OrsD PF12013.8 EEA27896.1 - 3 8.3 6.3 6.2 7.3 0.2 2.6 1 1 2 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D CDC27 PF09507.10 EEA27896.1 - 6.8 6.0 30.8 10 5.4 30.8 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SOBP PF15279.6 EEA27896.1 - 8.7 6.9 11.6 11 6.6 11.6 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Motile_Sperm PF00635.26 EEA27897.1 - 3.4e-24 84.8 0.0 1.4e-23 82.8 0.0 1.9 1 1 1 2 2 2 1 MSP (Major sperm protein) domain ASH PF15780.5 EEA27897.1 - 0.0089 16.2 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF5319 PF17252.2 EEA27897.1 - 0.027 14.7 0.2 0.052 13.8 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5319) FixG_C PF11614.8 EEA27897.1 - 0.029 14.6 0.0 0.054 13.7 0.0 1.4 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase FA_desaturase PF00487.24 EEA27898.1 - 1.1e-27 97.5 9.4 1.7e-27 96.9 9.4 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 EEA27898.1 - 8.4e-18 63.6 0.3 8.4e-18 63.6 0.3 2.0 2 0 0 2 2 2 1 Sphingolipid Delta4-desaturase (DES) Peptidase_M24 PF00557.24 EEA27899.1 - 6.2e-44 150.2 0.2 8.2e-44 149.8 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Pectinesterase PF01095.19 EEA27899.1 - 0.021 13.6 0.1 0.033 12.9 0.1 1.2 1 0 0 1 1 1 0 Pectinesterase Drc1-Sld2 PF11719.8 EEA27899.1 - 0.11 12.1 10.0 0.16 11.5 10.0 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein YL1 PF05764.13 EEA27899.1 - 0.16 12.0 11.2 0.26 11.4 11.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein UBA2_C PF16195.5 EEA27899.1 - 0.28 11.9 10.8 0.76 10.5 10.8 1.6 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus CCDC106 PF15794.5 EEA27899.1 - 1.7 8.3 8.2 2.6 7.7 8.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DnaJ PF00226.31 EEA27900.1 - 8.5e-23 80.3 0.7 8.5e-23 80.3 0.7 1.8 2 0 0 2 2 2 1 DnaJ domain Porin_3 PF01459.22 EEA27901.1 - 2.7e-77 259.9 3.0 3e-77 259.7 3.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Asn_synthase PF00733.21 EEA27902.1 - 8.4e-94 315.1 0.1 1.1e-54 186.4 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EEA27902.1 - 8.7e-37 125.8 0.0 1.5e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EEA27902.1 - 9.7e-27 93.8 0.0 2.5e-26 92.4 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EEA27902.1 - 3.1e-07 30.1 0.0 5.8e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EEA27902.1 - 0.0017 17.6 0.0 0.0037 16.4 0.0 1.7 1 1 0 1 1 1 1 NAD synthase QueC PF06508.13 EEA27902.1 - 0.1 12.1 0.1 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC UQ_con PF00179.26 EEA27903.1 - 5.9e-49 165.3 0.0 6.7e-49 165.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA27903.1 - 6.7e-06 25.8 0.0 0.0001 22.0 0.0 1.9 1 1 1 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 EEA27903.1 - 0.021 15.1 1.5 0.081 13.2 1.5 1.9 1 1 0 1 1 1 0 RWD domain G-patch PF01585.23 EEA27904.1 - 4.4e-09 36.1 2.5 9.1e-09 35.1 2.5 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EEA27904.1 - 9.5e-05 22.1 0.3 0.0015 18.3 0.1 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aminotran_4 PF01063.19 EEA27905.1 - 1.9e-34 119.5 0.0 2.5e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV bZIP_1 PF00170.21 EEA27906.1 - 0.0012 18.9 7.8 0.0026 17.8 7.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EEA27906.1 - 0.0033 17.5 6.5 0.0056 16.7 6.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EEA27906.1 - 0.04 14.4 5.4 0.091 13.3 5.4 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor CK_II_beta PF01214.18 EEA27907.1 - 2.2e-78 262.2 0.0 6.4e-78 260.7 0.0 1.6 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Spt5_N PF11942.8 EEA27907.1 - 0.1 13.6 10.2 0.1 13.6 6.7 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF4637 PF15470.6 EEA27907.1 - 0.15 11.8 3.1 0.36 10.6 3.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RRN3 PF05327.11 EEA27907.1 - 0.4 9.2 1.5 0.53 8.8 1.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EEA27907.1 - 2.1 6.3 4.4 2.8 5.9 4.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 EEA27907.1 - 3.7 8.0 10.6 7.6 7.0 9.9 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EEA27907.1 - 4.4 6.5 5.7 7.3 5.8 5.7 1.3 1 0 0 1 1 1 0 NOA36 protein CK_II_beta PF01214.18 EEA27908.1 - 2.2e-78 262.2 0.0 6.4e-78 260.7 0.0 1.6 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Spt5_N PF11942.8 EEA27908.1 - 0.1 13.6 10.2 0.1 13.6 6.7 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF4637 PF15470.6 EEA27908.1 - 0.15 11.8 3.1 0.36 10.6 3.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RRN3 PF05327.11 EEA27908.1 - 0.4 9.2 1.5 0.53 8.8 1.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EEA27908.1 - 2.1 6.3 4.4 2.8 5.9 4.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 EEA27908.1 - 3.7 8.0 10.6 7.6 7.0 9.9 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EEA27908.1 - 4.4 6.5 5.7 7.3 5.8 5.7 1.3 1 0 0 1 1 1 0 NOA36 protein Fungal_trans PF04082.18 EEA27909.1 - 1.5e-15 57.0 0.0 2.5e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA27909.1 - 2.1e-08 34.2 8.3 3.5e-08 33.4 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NPV_P10 PF05531.12 EEA27909.1 - 0.092 13.2 0.2 0.2 12.2 0.2 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein MSA-2c PF12238.8 EEA27909.1 - 0.73 9.8 2.3 1.6 8.7 2.3 1.6 1 0 0 1 1 1 0 Merozoite surface antigen 2c Cupin_8 PF13621.6 EEA27910.1 - 1.9e-28 99.9 0.0 2.4e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EEA27910.1 - 9e-05 22.1 0.0 0.00019 21.0 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EEA27910.1 - 0.0064 16.9 0.0 0.036 14.5 0.0 2.2 3 0 0 3 3 3 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 EEA27910.1 - 0.053 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Cupin domain BRO1 PF03097.18 EEA27911.1 - 1.2e-123 412.8 0.0 2.6e-123 411.7 0.0 1.6 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EEA27911.1 - 1.6e-86 290.3 12.1 1.6e-86 290.3 12.1 1.9 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV TPR_MLP1_2 PF07926.12 EEA27911.1 - 0.39 10.8 8.7 0.63 10.1 6.5 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Mito_carr PF00153.27 EEA27912.1 - 2.9e-42 142.5 7.7 6.9e-16 58.0 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Thiolase_N PF00108.23 EEA27913.1 - 1.7e-16 60.4 0.0 7.6e-16 58.3 0.0 2.0 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EEA27913.1 - 3.2e-12 46.2 1.2 3.3e-10 39.7 0.1 2.5 1 1 1 2 2 2 2 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EEA27913.1 - 4.2e-05 23.3 0.1 0.0049 16.7 0.0 2.7 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SpoVAD PF07451.11 EEA27913.1 - 0.02 13.6 1.7 0.078 11.7 0.0 2.4 3 0 0 3 3 3 0 Stage V sporulation protein AD (SpoVAD) CHD5 PF04420.14 EEA27915.1 - 6.9e-60 201.5 0.1 8.6e-60 201.2 0.1 1.1 1 0 0 1 1 1 1 CHD5-like protein CcmD PF04995.14 EEA27915.1 - 0.012 15.7 0.5 0.012 15.7 0.5 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) PPTA PF01239.22 EEA27916.1 - 1.9e-05 24.2 2.4 0.65 9.8 0.3 3.6 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat zf-C3HC PF07967.13 EEA27916.1 - 0.047 13.7 0.2 0.093 12.8 0.2 1.4 1 0 0 1 1 1 0 C3HC zinc finger-like zf-MYND PF01753.18 EEA27917.1 - 7.3e-11 42.0 14.4 7.3e-11 42.0 14.4 2.3 3 0 0 3 3 3 1 MYND finger Ecl1 PF12855.7 EEA27917.1 - 1.5 10.0 26.3 0.34 12.1 21.8 2.1 2 1 0 2 2 2 0 ECL1/2/3 zinc binding proteins ANAPC1 PF12859.7 EEA27917.1 - 7.9 7.0 9.9 1.2 9.7 5.3 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 RRM_1 PF00076.22 EEA27918.1 - 1.7e-14 53.4 0.0 4.3e-14 52.1 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA27918.1 - 0.0039 17.2 0.3 0.016 15.2 0.1 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif SMN PF06003.12 EEA27919.1 - 3.1e-09 36.5 0.2 7.8e-05 22.1 0.1 2.2 2 0 0 2 2 2 2 Survival motor neuron protein (SMN) Cu_bind_like PF02298.17 EEA27920.1 - 0.003 17.5 0.3 0.014 15.4 0.3 1.9 1 1 0 1 1 1 1 Plastocyanin-like domain 4F5 PF04419.14 EEA27921.1 - 1.1e-10 42.2 10.7 1.1e-10 42.2 10.7 2.1 1 1 1 2 2 2 1 4F5 protein family DFRP_C PF16543.5 EEA27921.1 - 0.71 10.4 6.4 0.89 10.1 6.4 1.1 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 DUF997 PF06196.12 EEA27922.1 - 0.0012 18.8 0.0 0.0012 18.8 0.0 1.9 2 1 1 3 3 3 1 Protein of unknown function (DUF997) TRAM_LAG1_CLN8 PF03798.16 EEA27924.1 - 2.8e-40 138.2 27.8 3.7e-39 134.5 23.5 2.1 2 0 0 2 2 2 2 TLC domain TRAM1 PF08390.11 EEA27924.1 - 3.2e-16 58.7 0.2 3.2e-16 58.7 0.2 1.8 2 0 0 2 2 2 1 TRAM1-like protein TRAM_LAG1_CLN8 PF03798.16 EEA27925.1 - 1.1e-39 136.2 29.6 3e-39 134.8 23.5 2.0 2 0 0 2 2 2 2 TLC domain TRAM1 PF08390.11 EEA27925.1 - 2.9e-16 58.9 0.2 2.9e-16 58.9 0.2 1.8 2 0 0 2 2 2 1 TRAM1-like protein Rad10 PF03834.14 EEA27927.1 - 1.1e-47 160.8 0.1 1.6e-47 160.2 0.1 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EEA27927.1 - 0.00012 22.6 0.0 0.00025 21.6 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 EEA27927.1 - 0.0027 17.5 0.0 0.0062 16.4 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.7 EEA27927.1 - 0.013 15.5 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif RRM_1 PF00076.22 EEA27928.1 - 5.8e-60 199.0 0.1 7e-19 67.4 0.1 5.5 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EEA27928.1 - 1.1e-06 29.0 0.1 8.3 6.6 0.0 6.5 5 3 3 8 8 8 1 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 EEA27928.1 - 0.00036 20.4 0.0 0.3 10.9 0.0 3.1 3 0 0 3 3 3 2 Rrp7 RRM-like N-terminal domain TFIIA PF03153.13 EEA27928.1 - 0.0011 19.0 11.9 0.0011 19.0 11.9 2.5 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit RRM_7 PF16367.5 EEA27928.1 - 0.0042 17.2 0.0 13 6.0 0.0 3.8 3 1 0 3 3 3 1 RNA recognition motif DbpA PF03880.15 EEA27928.1 - 0.0079 16.2 0.1 2 8.5 0.0 2.7 2 0 0 2 2 2 1 DbpA RNA binding domain Limkain-b1 PF11608.8 EEA27928.1 - 0.019 15.0 0.3 0.36 10.9 0.1 3.1 3 0 0 3 3 3 0 Limkain b1 SET_assoc PF11767.8 EEA27928.1 - 0.034 13.8 0.0 4.1 7.1 0.0 3.3 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated RRM_5 PF13893.6 EEA27928.1 - 0.044 13.4 0.0 2.8 7.5 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EEA27928.1 - 0.047 13.9 0.0 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 BRCA1-associated protein 2 Cyt-b5 PF00173.28 EEA27929.1 - 6.9e-10 38.9 0.0 8.1e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Fungal_trans PF04082.18 EEA27930.1 - 4.4e-20 71.8 0.5 4.4e-20 71.8 0.5 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain HBM PF16591.5 EEA27930.1 - 0.18 11.2 4.4 2.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Helical bimodular sensor domain Aldo_ket_red PF00248.21 EEA27931.1 - 8.8e-48 163.0 0.0 7.2e-47 160.0 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family DHquinase_I PF01487.15 EEA27932.1 - 4.8e-43 148.0 0.0 7.5e-43 147.4 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase DENN PF02141.21 EEA27933.1 - 7e-58 195.6 0.1 1.4e-57 194.6 0.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EEA27933.1 - 8.2e-15 55.3 0.0 2.2e-14 53.9 0.0 1.8 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EEA27933.1 - 1.9e-13 50.2 0.4 5.2e-13 48.8 0.4 1.8 1 0 0 1 1 1 1 dDENN domain C1_2 PF03107.16 EEA27933.1 - 2.8e-06 27.5 4.1 5.5e-06 26.6 4.1 1.5 1 0 0 1 1 1 1 C1 domain PHD PF00628.29 EEA27933.1 - 0.008 16.0 5.3 0.008 16.0 5.3 2.0 1 1 1 2 2 2 1 PHD-finger C1_1 PF00130.22 EEA27933.1 - 0.41 10.6 9.9 0.77 9.7 9.9 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EEA27933.1 - 2.1 8.5 6.9 5.5 7.2 6.9 1.7 1 1 0 1 1 1 0 KIAA1045 RING finger zf-HIT PF04438.16 EEA27933.1 - 6.5 6.7 7.8 15 5.5 7.9 1.6 1 1 0 1 1 1 0 HIT zinc finger DDE_3 PF13358.6 EEA27934.1 - 7.3e-12 45.3 0.2 2.1e-11 43.8 0.2 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EEA27934.1 - 6.3e-10 39.2 0.5 1.7e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EEA27934.1 - 0.0015 18.3 1.6 0.0062 16.3 0.2 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_12 PF08461.10 EEA27934.1 - 0.0077 16.2 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_38 PF13936.6 EEA27934.1 - 0.0092 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4350 PF14258.6 EEA27934.1 - 0.0093 16.4 0.1 13 6.3 0.0 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF4350) HTH_32 PF13565.6 EEA27934.1 - 0.014 16.0 11.1 0.14 12.8 0.6 3.7 2 1 2 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.6 EEA27934.1 - 0.034 13.8 1.2 7 6.4 0.1 3.0 2 1 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EEA27934.1 - 0.042 13.9 0.0 9.1 6.5 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DUF2774 PF11242.8 EEA27934.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EEA27934.1 - 0.21 11.3 0.5 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 DoxX_2 PF13564.6 EEA27935.1 - 0.021 14.9 0.7 0.03 14.4 0.3 1.5 2 0 0 2 2 2 0 DoxX-like family DUF974 PF06159.13 EEA27936.1 - 1.1e-78 264.5 0.0 1.3e-78 264.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) zf-RING_2 PF13639.6 EEA27937.1 - 9.4e-08 32.3 6.3 9.4e-08 32.3 6.3 1.9 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EEA27937.1 - 0.00016 21.7 1.9 0.00016 21.7 1.9 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger SWIM PF04434.17 EEA27937.1 - 0.0051 16.5 0.1 0.01 15.5 0.1 1.5 1 0 0 1 1 1 1 SWIM zinc finger FANCL_C PF11793.8 EEA27937.1 - 0.0054 16.9 5.5 0.013 15.6 5.5 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain Prok-RING_1 PF14446.6 EEA27937.1 - 0.0095 15.8 1.7 0.0095 15.8 1.7 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 EEA27937.1 - 0.011 15.5 6.4 0.022 14.5 6.4 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 EEA27937.1 - 0.033 14.3 8.2 0.076 13.1 8.2 1.7 1 0 0 1 1 1 0 RING-variant domain PHD PF00628.29 EEA27937.1 - 0.1 12.5 7.0 0.23 11.4 7.0 1.6 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 EEA27937.1 - 1.2 9.1 7.2 2.2 8.3 3.1 2.4 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 EEA27937.1 - 1.6 9.1 6.9 1 9.7 3.9 2.3 2 1 0 2 2 2 0 RING-like domain zf-RING_5 PF14634.6 EEA27937.1 - 3.2 7.8 12.8 0.16 12.0 6.3 2.1 2 0 0 2 2 2 0 zinc-RING finger domain zf-rbx1 PF12678.7 EEA27937.1 - 3.6 8.0 9.6 0.41 11.0 4.7 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EEA27937.1 - 9.3 6.4 11.1 0.73 9.9 5.8 2.0 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_11 PF17123.5 EEA27937.1 - 9.8 6.0 8.0 1.3 8.9 3.4 1.9 2 0 0 2 2 2 0 RING-like zinc finger CENP-N PF05238.13 EEA27938.1 - 3e-129 432.0 0.0 3.3e-129 431.8 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like bZIP_2 PF07716.15 EEA27939.1 - 1.5e-12 47.4 14.1 2.7e-12 46.6 14.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EEA27939.1 - 0.0011 19.1 10.4 0.0018 18.3 10.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor TSC22 PF01166.18 EEA27939.1 - 0.09 13.1 0.8 0.22 11.8 0.8 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family YabA PF06156.13 EEA27939.1 - 3 8.6 6.0 2.6 8.7 3.4 2.1 2 1 0 2 2 2 0 Initiation control protein YabA CCDC106 PF15794.5 EEA27939.1 - 3.8 7.2 17.3 0.55 9.9 3.3 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 Pro_CA PF00484.19 EEA27941.1 - 0.0053 17.1 0.0 0.0073 16.6 0.0 1.3 1 0 0 1 1 1 1 Carbonic anhydrase Maf PF02545.14 EEA27941.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Maf-like protein HATPase_c_3 PF13589.6 EEA27942.1 - 5e-16 58.8 0.0 1.1e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 EEA27942.1 - 1.7e-05 24.7 0.0 0.00029 20.6 0.0 2.5 2 0 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 EEA27942.1 - 0.11 13.0 0.1 0.38 11.3 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RasGEF PF00617.19 EEA27944.1 - 3.3e-50 170.7 0.3 5.5e-50 170.0 0.3 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EEA27944.1 - 6e-15 55.4 0.0 1e-13 51.4 0.0 2.6 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_9 PF14604.6 EEA27944.1 - 4.3e-06 26.5 0.0 1.3e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EEA27944.1 - 3.5e-05 23.3 0.0 0.00011 21.8 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EEA27944.1 - 0.0065 16.1 0.0 0.019 14.6 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain RNA_capsid PF03035.14 EEA27944.1 - 0.2 11.6 4.1 0.18 11.8 2.3 1.9 2 0 0 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein Med5 PF08689.10 EEA27945.1 - 7.9e-159 530.6 0.0 1.5e-157 526.4 0.0 2.3 1 1 0 1 1 1 1 Mediator complex subunit Med5 Arm_vescicular PF18770.1 EEA27945.1 - 0.16 12.0 0.1 0.75 9.8 0.0 2.2 2 0 0 2 2 2 0 Armadillo tether-repeat of vescicular transport factor Aldo_ket_red PF00248.21 EEA27947.1 - 1.6e-40 139.1 0.0 1.7e-31 109.5 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Aldo_ket_red PF00248.21 EEA27948.1 - 1.2e-40 139.5 0.0 2.3e-38 132.1 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family ELFV_dehydrog PF00208.21 EEA27949.1 - 7.9e-82 274.6 2.2 9.9e-82 274.3 2.2 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EEA27949.1 - 6.6e-51 171.6 0.0 1.1e-50 170.8 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain FMO-like PF00743.19 EEA27949.1 - 0.01 14.3 0.0 0.015 13.7 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Qn_am_d_aIV PF09100.10 EEA27949.1 - 0.041 13.7 0.5 0.085 12.7 0.1 1.7 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV NAD_binding_7 PF13241.6 EEA27949.1 - 0.071 13.6 0.3 0.18 12.2 0.3 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding DUF3395 PF11875.8 EEA27950.1 - 0.05 13.5 1.1 6.7 6.6 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3395) MFS_1 PF07690.16 EEA27951.1 - 5e-09 35.6 39.8 5e-09 35.6 39.8 3.9 2 2 1 3 3 3 2 Major Facilitator Superfamily DPBB_1 PF03330.18 EEA27952.1 - 1.6e-06 28.3 0.1 3.3e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EEA27952.1 - 0.07 13.0 0.4 0.13 12.2 0.4 1.3 1 0 0 1 1 1 0 Barwin family Fimbrial_PilY2 PF14481.6 EEA27952.1 - 0.2 11.3 1.5 0.25 11.0 0.4 1.6 2 0 0 2 2 2 0 Type 4 fimbrial biogenesis protein PilY2 FAP PF07174.11 EEA27952.1 - 4.4 6.7 51.0 5.9 6.2 51.0 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Ribonuc_red_lgC PF02867.15 EEA27953.1 - 5.3e-187 622.5 0.0 8.9e-187 621.8 0.0 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EEA27953.1 - 1.2e-25 89.3 0.1 2.9e-25 88.1 0.1 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EEA27953.1 - 6.2e-17 61.9 0.0 1.5e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain PRK PF00485.18 EEA27954.1 - 0.00027 20.7 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EEA27954.1 - 0.00041 20.9 0.0 0.0029 18.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EEA27954.1 - 0.00046 19.5 0.0 0.00066 18.9 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain T2SSE PF00437.20 EEA27954.1 - 0.0073 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 EEA27954.1 - 0.0091 16.2 0.1 3.6 7.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EEA27954.1 - 0.013 15.9 0.1 0.017 15.5 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EEA27954.1 - 0.029 13.7 0.0 0.089 12.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.6 EEA27954.1 - 0.034 14.6 0.0 1.5 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EEA27954.1 - 0.037 14.4 0.0 0.062 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA27954.1 - 0.054 13.8 0.0 0.1 12.8 0.0 1.5 2 0 0 2 2 1 0 AAA domain DUF87 PF01935.17 EEA27954.1 - 0.071 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain RuvB_N PF05496.12 EEA27954.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 EEA27954.1 - 0.13 12.8 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Torsin PF06309.11 EEA27954.1 - 0.15 12.1 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Torsin DUF2075 PF09848.9 EEA27954.1 - 0.19 10.9 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Cytidylate_kin PF02224.18 EEA27954.1 - 0.21 11.3 0.8 0.3 10.8 0.1 1.6 2 0 0 2 2 2 0 Cytidylate kinase Asp PF00026.23 EEA27956.1 - 7.7e-54 183.2 0.0 9.2e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EEA27956.1 - 0.0041 17.7 0.0 1.8 9.3 0.0 2.6 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 EEA27956.1 - 0.048 13.9 0.0 21 5.3 0.0 2.9 3 0 0 3 3 3 0 Xylanase inhibitor N-terminal ArabFuran-catal PF09206.11 EEA27957.1 - 1e-152 508.0 13.8 1.6e-152 507.3 13.8 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 EEA27957.1 - 1.2e-56 190.6 4.1 2.2e-56 189.7 4.1 1.5 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain Mur_ligase_M PF08245.12 EEA27958.1 - 8.5e-08 32.4 0.1 2.2e-07 31.0 0.1 1.7 1 1 0 1 1 1 1 Mur ligase middle domain Pkinase PF00069.25 EEA27959.1 - 3.6e-73 246.2 0.0 1.7e-72 244.0 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27959.1 - 1.4e-51 175.3 0.0 7.1e-51 173.0 0.0 2.1 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA27959.1 - 0.00031 19.7 0.0 0.00082 18.2 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EEA27959.1 - 0.0021 17.4 0.0 0.04 13.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like HEAT PF02985.22 EEA27959.1 - 0.0095 16.1 0.8 29 5.3 0.0 4.4 3 0 0 3 3 3 0 HEAT repeat GerD PF17898.1 EEA27959.1 - 0.024 14.6 1.2 0.069 13.1 1.2 1.8 1 0 0 1 1 1 0 Spore germination GerD central core domain DUF3385 PF11865.8 EEA27959.1 - 0.066 13.1 1.2 0.36 10.7 1.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3385) DUF383 PF04063.14 EEA27959.1 - 0.18 11.4 3.1 0.59 9.8 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF383) EF-G-binding_N PF07299.11 EEA27959.1 - 0.19 12.3 0.3 1.2 9.8 0.1 2.5 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal ABC1 PF03109.16 EEA27960.1 - 1.3e-33 115.7 0.0 2.2e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EEA27960.1 - 0.016 14.8 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 RIO1 family YCII PF03795.14 EEA27961.1 - 1.3e-09 38.3 0.0 1.7e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Anp1 PF03452.14 EEA27962.1 - 3.1e-106 354.6 0.0 4.7e-106 354.0 0.0 1.3 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EEA27962.1 - 0.0079 16.0 0.1 0.33 10.8 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Bap31_Bap29_C PF18035.1 EEA27963.1 - 0.048 13.7 2.1 0.12 12.4 2.1 1.6 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 EEA27963.1 - 0.05 13.4 1.8 0.1 12.4 1.8 1.5 1 0 0 1 1 1 0 Septum formation initiator Terpene_synth_C PF03936.16 EEA27963.1 - 0.062 12.6 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain Macoilin PF09726.9 EEA27963.1 - 0.07 11.7 0.5 0.12 11.0 0.5 1.3 1 0 0 1 1 1 0 Macoilin family YabA PF06156.13 EEA27963.1 - 0.39 11.4 2.4 2.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Initiation control protein YabA bZIP_1 PF00170.21 EEA27963.1 - 0.67 10.1 4.2 0.15 12.1 0.4 1.9 2 0 0 2 2 2 0 bZIP transcription factor Ecm33 PF12454.8 EEA27964.1 - 2.1e-14 53.3 3.6 6.4e-14 51.8 3.6 1.9 1 0 0 1 1 1 1 GPI-anchored cell wall organization protein Recep_L_domain PF01030.24 EEA27964.1 - 4.4e-09 36.5 1.1 0.37 10.9 0.0 5.0 1 1 4 5 5 5 3 Receptor L domain LRR_5 PF13306.6 EEA27964.1 - 7.9e-05 22.6 5.1 0.055 13.4 1.9 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) SR-25 PF10500.9 EEA27964.1 - 7 6.2 10.1 11 5.5 10.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HhH-GPD PF00730.25 EEA27965.1 - 6.8e-15 55.4 0.0 2e-14 54.0 0.0 1.7 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein UCR_14kD PF02271.16 EEA27966.1 - 4.2e-43 145.4 0.5 4.9e-43 145.2 0.5 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.27 EEA27967.1 - 6.7e-62 205.4 2.3 3.6e-22 78.1 0.1 3.4 2 2 1 3 3 3 3 Mitochondrial carrier protein Pkinase PF00069.25 EEA27968.1 - 8.5e-17 61.4 0.0 5e-16 58.9 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA27968.1 - 2.1e-09 37.1 0.0 2.4e-08 33.6 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Peptidase_M49 PF03571.15 EEA27969.1 - 9.9e-246 816.4 0.0 1.3e-245 816.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 Peptidase_M49 PF03571.15 EEA27970.1 - 9.8e-246 816.4 0.0 1.3e-245 816.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 Peptidase_M49 PF03571.15 EEA27971.1 - 9.8e-246 816.4 0.0 1.3e-245 816.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 SNF5 PF04855.12 EEA27972.1 - 5.4e-85 285.0 0.0 6.8e-85 284.6 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 EEA27972.1 - 0.00054 19.5 0.5 0.0018 17.9 0.5 2.0 1 0 0 1 1 1 1 GATA zinc finger zf-CCHC_4 PF14392.6 EEA27972.1 - 0.46 10.3 3.2 0.27 11.0 0.3 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 EEA27972.1 - 0.66 9.9 5.0 0.088 12.7 0.5 1.9 2 0 0 2 2 2 0 Zinc knuckle FixO PF02433.15 EEA27973.1 - 0.011 15.1 2.3 0.019 14.4 2.3 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO FixO PF02433.15 EEA27974.1 - 0.011 15.1 2.3 0.019 14.4 2.3 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO WD40 PF00400.32 EEA27975.1 - 9.3e-25 86.4 24.0 6.5e-06 26.8 0.3 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA27975.1 - 2.1e-10 40.7 7.6 0.0019 18.5 0.2 4.6 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EEA27975.1 - 2e-06 27.9 6.7 0.016 15.1 0.2 2.5 1 1 1 2 2 2 2 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 EEA27975.1 - 0.0077 15.2 0.4 1.2 8.0 0.0 3.7 2 2 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein F-box-like PF12937.7 EEA27976.1 - 0.0002 21.2 0.1 0.00046 20.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA27976.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 F-box domain Sugar_tr PF00083.24 EEA27977.1 - 9.1e-106 354.4 22.9 1.1e-105 354.1 22.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA27977.1 - 8.5e-25 87.4 29.4 8.5e-25 87.4 29.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 EEA27977.1 - 0.00018 20.5 6.0 0.00018 20.5 6.0 2.3 2 0 0 2 2 2 1 LacY proton/sugar symporter MFS_3 PF05977.13 EEA27977.1 - 0.0022 16.5 3.2 0.0022 16.5 3.2 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector ABC_tran PF00005.27 EEA27978.1 - 9e-47 159.0 0.4 2e-22 80.2 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EEA27978.1 - 5.4e-20 71.2 7.3 5.4e-20 71.2 7.3 3.2 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 EEA27978.1 - 3.7e-14 53.2 12.1 0.0026 17.6 0.0 4.5 3 2 1 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA27978.1 - 6.2e-12 45.4 0.7 0.0039 16.7 0.1 4.4 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EEA27978.1 - 9.4e-07 29.2 0.0 0.017 15.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 EEA27978.1 - 5.1e-06 26.5 0.1 0.058 13.3 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EEA27978.1 - 5.7e-06 26.4 0.0 0.055 13.5 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_30 PF13604.6 EEA27978.1 - 6.5e-06 26.0 0.0 0.0032 17.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EEA27978.1 - 9.1e-06 26.3 12.1 0.031 14.8 0.0 4.7 5 0 0 5 5 5 2 AAA domain AAA_29 PF13555.6 EEA27978.1 - 1.2e-05 25.0 0.1 0.12 12.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA27978.1 - 1.9e-05 25.1 0.8 0.09 13.2 0.2 3.0 3 0 0 3 3 2 2 AAA ATPase domain AAA_18 PF13238.6 EEA27978.1 - 2.9e-05 24.6 0.9 0.52 10.9 0.0 3.3 4 0 0 4 4 2 2 AAA domain AAA_33 PF13671.6 EEA27978.1 - 6.3e-05 23.2 0.1 0.37 11.0 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EEA27978.1 - 0.00012 21.9 0.0 0.77 9.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EEA27978.1 - 0.00037 20.8 3.6 0.066 13.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EEA27978.1 - 0.00073 19.3 12.3 0.25 11.0 0.0 4.6 4 1 0 4 4 4 2 AAA ATPase domain AAA PF00004.29 EEA27978.1 - 0.00086 19.7 0.0 0.76 10.2 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 EEA27978.1 - 0.00089 19.4 0.6 3.1 7.8 0.0 3.5 3 0 0 3 3 3 1 Dynamin family AAA_14 PF13173.6 EEA27978.1 - 0.002 18.2 0.0 3.8 7.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EEA27978.1 - 0.0024 17.8 0.6 0.83 9.5 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_27 PF13514.6 EEA27978.1 - 0.0031 17.1 0.0 3.7 7.1 0.0 3.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA27978.1 - 0.0047 17.3 0.0 2.3 8.6 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Zeta_toxin PF06414.12 EEA27978.1 - 0.0078 15.5 1.0 2.9 7.1 0.1 3.2 3 0 0 3 3 3 1 Zeta toxin MeaB PF03308.16 EEA27978.1 - 0.0094 15.0 3.5 0.94 8.4 0.1 2.8 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 EEA27978.1 - 0.0098 15.8 0.0 0.45 10.4 0.0 2.8 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 EEA27978.1 - 0.018 15.0 0.0 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EEA27978.1 - 0.027 14.5 0.0 8.1 6.5 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EEA27978.1 - 0.027 14.4 0.1 4 7.3 0.0 3.1 2 1 0 3 3 3 0 Rad17 P-loop domain Roc PF08477.13 EEA27978.1 - 0.035 14.3 0.1 6.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EEA27978.1 - 0.063 13.3 0.3 7.5 6.6 0.0 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) DUF2813 PF11398.8 EEA27978.1 - 0.065 12.5 0.7 0.21 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) cobW PF02492.19 EEA27978.1 - 0.071 12.7 4.1 1 8.9 0.3 2.8 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EEA27978.1 - 0.072 12.6 0.0 6.4 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_19 PF13245.6 EEA27978.1 - 0.086 13.2 0.2 7.5 6.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EEA27978.1 - 0.11 11.6 0.8 14 4.8 0.1 2.5 2 1 0 2 2 2 0 NB-ARC domain SRP54 PF00448.22 EEA27978.1 - 0.12 12.0 0.6 4.7 6.8 0.1 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Arf PF00025.21 EEA27978.1 - 0.14 11.6 0.0 2.7 7.4 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family PRK PF00485.18 EEA27978.1 - 0.14 11.9 0.8 8.1 6.1 0.1 2.9 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 EEA27978.1 - 0.23 11.5 9.3 2.1 8.4 0.0 4.0 5 0 0 5 5 4 0 Helicase HerA, central domain AAA_17 PF13207.6 EEA27978.1 - 0.28 11.6 2.9 22 5.5 0.2 3.6 3 0 0 3 3 3 0 AAA domain MFS_1 PF07690.16 EEA27980.1 - 4.1e-39 134.5 34.3 4.1e-39 134.5 34.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA27980.1 - 1.9e-11 43.5 9.6 1.9e-11 43.5 9.6 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter SKG6 PF08693.10 EEA27981.1 - 0.012 15.0 1.6 0.02 14.3 1.6 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TMEM154 PF15102.6 EEA27981.1 - 0.044 13.7 0.0 0.08 12.8 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family YajC PF02699.15 EEA27981.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit PilX_N PF14341.6 EEA27981.1 - 0.33 10.9 2.7 0.7 9.9 2.7 1.5 1 0 0 1 1 1 0 PilX N-terminal SKG6 PF08693.10 EEA27982.1 - 9.6e-11 40.9 4.1 9.6e-11 40.9 4.1 2.9 3 0 0 3 3 3 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EEA27982.1 - 0.0051 16.6 0.1 0.0076 16.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) RIFIN PF02009.16 EEA27982.1 - 0.006 16.5 0.1 0.012 15.6 0.0 1.5 2 0 0 2 2 2 1 Rifin PMP1_2 PF08114.11 EEA27982.1 - 0.017 14.9 1.5 0.03 14.0 1.5 1.4 1 0 0 1 1 1 0 ATPase proteolipid family Adeno_E3_CR2 PF02439.15 EEA27982.1 - 0.12 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM154 PF15102.6 EEA27982.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.3 1 1 1 2 2 2 0 TMEM154 protein family Stevor PF17410.2 EEA27982.1 - 0.42 10.1 6.2 0.075 12.6 0.8 1.9 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame DUF4551 PF15087.6 EEA27982.1 - 5.5 5.7 9.4 6.9 5.4 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ank_2 PF12796.7 EEA27983.1 - 1e-28 99.7 4.0 8.5e-12 45.5 0.1 5.0 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA27983.1 - 1.3e-21 76.6 6.8 2.7e-08 34.2 0.0 6.2 2 1 6 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA27983.1 - 2.3e-18 66.0 6.2 0.00018 21.7 0.0 6.3 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA27983.1 - 3.8e-16 57.6 5.2 0.054 14.1 0.0 7.8 9 0 0 9 9 9 5 Ankyrin repeat SPX PF03105.19 EEA27983.1 - 4.9e-14 53.0 11.2 0.00032 20.7 0.0 3.2 1 1 2 3 3 3 3 SPX domain GDPD PF03009.17 EEA27983.1 - 1.1e-13 51.5 0.0 2.5e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank PF00023.30 EEA27983.1 - 1.4e-09 37.9 3.2 0.25 11.9 0.1 7.8 8 1 0 8 8 8 2 Ankyrin repeat Ank_2 PF12796.7 EEA27984.1 - 1.1e-28 99.7 4.7 7.4e-12 45.7 0.1 4.9 2 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA27984.1 - 9e-22 77.2 6.8 2.3e-08 34.4 0.0 6.1 2 1 6 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA27984.1 - 1.3e-18 66.8 6.5 0.00016 21.9 0.0 6.3 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA27984.1 - 1.7e-16 58.6 5.2 0.047 14.2 0.0 7.9 9 0 0 9 9 9 5 Ankyrin repeat SPX PF03105.19 EEA27984.1 - 3.5e-14 53.5 11.2 0.00029 20.9 0.0 3.2 1 1 2 3 3 3 3 SPX domain Ank PF00023.30 EEA27984.1 - 1.1e-09 38.2 4.1 0.22 12.0 0.1 7.9 8 1 0 8 8 8 2 Ankyrin repeat GDPD PF03009.17 EEA27984.1 - 5.8e-09 36.1 0.0 1.2e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF1279 PF06916.13 EEA27985.1 - 3.3e-25 88.5 0.0 7.2e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Presenilin PF01080.17 EEA27985.1 - 0.082 11.7 0.3 0.094 11.5 0.3 1.1 1 0 0 1 1 1 0 Presenilin DIRP PF06584.13 EEA27985.1 - 0.57 10.4 5.4 0.86 9.8 4.6 1.7 1 1 1 2 2 2 0 DIRP Ribosomal_L3 PF00297.22 EEA27986.1 - 6.7e-19 68.1 3.1 2.2e-15 56.5 0.9 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 Coa1 PF08695.10 EEA27987.1 - 3.8e-43 146.0 0.0 4.8e-43 145.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Alpha-L-AF_C PF06964.12 EEA27988.1 - 0.19 11.9 0.0 0.25 11.5 0.0 1.1 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminal domain DUF1772 PF08592.11 EEA27989.1 - 1.3 9.4 4.6 3.5 7.9 4.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DUF1772 PF08592.11 EEA27990.1 - 1.5 9.2 4.7 0.35 11.2 0.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) JmjC PF02373.22 EEA27991.1 - 1.6e-08 35.0 1.0 2e-07 31.4 1.0 2.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EEA27991.1 - 4.2e-06 26.9 9.5 4.2e-06 26.9 9.5 2.7 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 EEA27991.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Cupin domain UbiA PF01040.18 EEA27992.1 - 3.4e-45 154.3 18.0 4.5e-45 153.9 18.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Glutaredoxin PF00462.24 EEA27993.1 - 3.7e-17 62.3 0.0 6.7e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Glutaredoxin PF00462.24 EEA27994.1 - 3.7e-17 62.3 0.0 6.6e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin SOG2 PF10428.9 EEA27995.1 - 0.093 11.9 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein CTP_transf_like PF01467.26 EEA27996.1 - 2.3e-25 89.5 0.0 2.8e-22 79.4 0.0 3.1 3 0 0 3 3 3 2 Cytidylyltransferase-like PRELI PF04707.14 EEA27997.1 - 1.2e-41 142.2 0.4 1.3e-41 142.0 0.4 1.0 1 0 0 1 1 1 1 PRELI-like family AhpC-TSA PF00578.21 EEA27998.1 - 4e-22 78.4 0.0 6.8e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EEA27998.1 - 3e-13 49.7 0.0 3.9e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EEA27998.1 - 0.046 13.8 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme DUF1761 PF08570.10 EEA28002.1 - 2.6e-28 98.8 3.7 3e-28 98.6 3.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Methyltransf_16 PF10294.9 EEA28003.1 - 3.4e-43 147.4 0.0 4.5e-43 147.0 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Met_10 PF02475.16 EEA28003.1 - 0.0022 17.8 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EEA28003.1 - 0.028 14.0 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 EEA28003.1 - 0.045 14.4 0.0 0.072 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EEA28003.1 - 0.092 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Mpp10 PF04006.12 EEA28004.1 - 3.4e-109 366.0 34.3 4.7e-109 365.6 34.3 1.1 1 0 0 1 1 1 1 Mpp10 protein adh_short_C2 PF13561.6 EEA28005.1 - 8.9e-56 189.1 0.0 1.1e-55 188.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA28005.1 - 8.5e-44 149.4 0.0 1e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA28005.1 - 4.8e-09 36.4 0.0 7e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 KR domain PALP PF00291.25 EEA28005.1 - 0.037 13.4 0.1 0.055 12.9 0.1 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Polysacc_synt_2 PF02719.15 EEA28005.1 - 0.13 11.3 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EEA28005.1 - 0.18 11.1 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Oxidored_q6 PF01058.22 EEA28006.1 - 2.9e-22 78.9 0.0 4.5e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Sedlin_N PF04628.13 EEA28007.1 - 5.9e-12 45.8 0.0 8.1e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sedlin_N PF04628.13 EEA28008.1 - 4.6e-06 26.8 0.0 5.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sedlin_N PF04628.13 EEA28009.1 - 8.1e-10 38.9 0.0 2e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Acyl_transf_1 PF00698.21 EEA28010.1 - 3.3e-18 66.3 0.0 1.3e-10 41.3 0.1 2.2 1 1 1 2 2 2 2 Acyl transferase domain Acyl_transf_1 PF00698.21 EEA28011.1 - 3.3e-18 66.3 0.0 1.3e-10 41.3 0.1 2.2 1 1 1 2 2 2 2 Acyl transferase domain Nucleoporin_C PF03177.14 EEA28012.1 - 2.4e-167 558.3 4.1 3.5e-167 557.7 4.1 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EEA28012.1 - 5.1e-47 160.6 0.0 6.6e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like RNase_H PF00075.24 EEA28013.1 - 7.6e-09 35.9 0.0 1.5e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 EEA28013.1 - 0.00023 21.8 0.0 0.00044 20.9 0.0 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_3 PF13456.6 EEA28013.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like HTH_Tnp_Tc5 PF03221.16 EEA28014.1 - 4.3e-10 39.5 0.0 1e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-CCHC PF00098.23 EEA28014.1 - 0.012 15.7 1.4 0.02 15.0 1.4 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EEA28014.1 - 0.022 14.6 1.0 0.035 14.0 1.0 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EEA28014.1 - 0.037 13.8 1.1 0.08 12.7 1.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 EEA28014.1 - 0.31 10.9 1.9 0.52 10.2 0.9 1.9 1 1 1 2 2 2 0 Zinc knuckle DDE_1 PF03184.19 EEA28015.1 - 9.9e-14 51.4 0.0 1.6e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA28015.1 - 5e-13 48.9 0.0 4e-12 46.0 0.0 2.5 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_Tnp_1_7 PF13843.6 EEA28016.1 - 5.7e-58 196.9 0.3 1.1e-57 195.9 0.3 1.5 1 1 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.6 EEA28016.1 - 6.9e-12 46.0 9.4 1.6e-11 44.8 9.4 1.7 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon DUF948 PF06103.11 EEA28017.1 - 0.021 15.1 0.5 0.041 14.1 0.5 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Gln-synt_C PF00120.24 EEA28017.1 - 0.03 13.3 0.4 0.047 12.7 0.4 1.3 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain CR6_interact PF10147.9 EEA28017.1 - 0.27 10.9 5.3 0.25 11.0 1.8 2.1 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 UCH PF00443.29 EEA28018.1 - 2.7e-38 131.9 0.0 4.1e-38 131.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EEA28018.1 - 2.9e-26 91.0 3.6 3.5e-25 87.5 0.4 2.6 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 EEA28018.1 - 7.2e-24 83.9 18.3 1.4e-20 73.3 1.3 3.9 3 1 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 EEA28018.1 - 4.2e-17 61.7 0.7 2.2e-09 37.0 0.2 2.6 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 EEA28018.1 - 7.3e-16 58.6 0.0 5.3e-14 52.5 0.0 3.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase HTH_psq PF05225.16 EEA28018.1 - 9.1e-06 25.3 0.0 1.8e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 EEA28018.1 - 0.079 13.0 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain UBA_4 PF14555.6 EEA28018.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain zf-RING_UBOX PF13445.6 EEA28018.1 - 1.5 8.9 9.3 11 6.1 4.5 3.4 3 0 0 3 3 3 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA28018.1 - 1.7 8.5 10.8 0.15 11.9 2.4 3.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA28018.1 - 7.6 6.5 10.2 10 6.1 1.2 3.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) UCH PF00443.29 EEA28019.1 - 1.7e-38 132.6 0.0 2.6e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EEA28019.1 - 2.7e-26 91.1 4.1 2.8e-25 87.9 0.4 2.6 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 EEA28019.1 - 5.3e-24 84.3 18.7 1.1e-20 73.6 1.3 3.9 3 1 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 EEA28019.1 - 2.8e-17 62.2 0.7 1.8e-09 37.3 0.2 2.6 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 EEA28019.1 - 5.4e-16 59.1 0.6 3.4e-14 53.1 0.0 3.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 EEA28019.1 - 0.11 12.3 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain zf-RING_UBOX PF13445.6 EEA28019.1 - 0.85 9.7 9.3 9.2 6.4 4.5 3.5 3 0 0 3 3 3 0 RING-type zinc-finger Rep_fac-A_C PF08646.10 EEA28020.1 - 5.6e-55 185.1 3.1 4.1e-54 182.3 1.5 2.3 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EEA28020.1 - 7.9e-37 125.1 0.5 1.9e-36 123.9 0.2 1.8 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 EEA28020.1 - 9.9e-23 80.1 0.1 2.2e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 EEA28020.1 - 9.9e-12 44.7 0.0 2.1e-08 34.0 0.0 3.5 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EEA28020.1 - 0.0025 17.5 0.4 0.14 11.8 0.0 2.9 3 0 0 3 3 3 1 Cell division control protein 24, OB domain 3 DUF223 PF02721.14 EEA28020.1 - 0.11 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function DUF223 ADH_zinc_N PF00107.26 EEA28021.1 - 2.4e-22 79.3 0.1 4.2e-22 78.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA28021.1 - 1.7e-19 71.2 0.0 2.8e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA28021.1 - 2.1e-10 40.5 0.0 3.6e-09 36.5 0.0 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF735 PF05246.11 EEA28021.1 - 0.13 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF735) DEAD PF00270.29 EEA28022.1 - 4.4e-48 163.4 0.1 1.3e-47 161.9 0.0 1.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA28022.1 - 1.1e-31 109.4 0.0 7.6e-30 103.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA28022.1 - 7.8e-07 29.3 0.3 1.1e-05 25.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EEA28022.1 - 0.025 13.9 0.0 0.025 13.9 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 EEA28022.1 - 0.07 12.3 0.0 0.07 12.3 0.0 2.0 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase Bud13 PF09736.9 EEA28022.1 - 0.52 10.7 7.3 1.1 9.7 7.3 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DEAD PF00270.29 EEA28023.1 - 3.3e-48 163.8 0.1 1e-47 162.2 0.0 1.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA28023.1 - 8.1e-32 109.9 0.0 6.3e-30 103.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA28023.1 - 5.7e-07 29.7 0.3 8.5e-06 25.9 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EEA28023.1 - 0.021 14.2 0.0 0.021 14.2 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 EEA28023.1 - 0.062 12.5 0.0 0.062 12.5 0.0 2.0 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase DUF2075 PF09848.9 EEA28023.1 - 0.26 10.5 0.0 0.26 10.5 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Bud13 PF09736.9 EEA28023.1 - 0.45 10.9 7.3 0.91 9.9 7.3 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Rft-1 PF04506.13 EEA28024.1 - 5.1e-139 464.3 12.1 6.1e-139 464.1 12.1 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt PF01943.17 EEA28024.1 - 1.2e-08 34.7 4.7 1.2e-08 34.7 4.7 2.8 3 0 0 3 3 3 1 Polysaccharide biosynthesis protein Polysacc_synt_3 PF13440.6 EEA28024.1 - 0.001 18.4 18.0 0.0014 18.0 9.6 3.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein FA_desaturase PF00487.24 EEA28024.1 - 0.52 10.1 11.2 1.4 8.7 4.6 2.6 2 0 0 2 2 2 0 Fatty acid desaturase DUF4212 PF13937.6 EEA28024.1 - 2.3 8.7 6.6 1.4 9.4 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) OST3_OST6 PF04756.13 EEA28025.1 - 3.2e-104 348.4 0.0 3.8e-104 348.2 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 EEA28025.1 - 0.019 15.0 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin HXXEE PF13787.6 EEA28025.1 - 0.056 14.2 0.3 0.056 14.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif FtsJ PF01728.19 EEA28026.1 - 9.7e-58 195.2 0.0 2e-56 190.9 0.0 2.4 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 EEA28026.1 - 0.022 14.6 0.0 0.065 13.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain FapA PF03961.13 EEA28026.1 - 0.038 12.6 24.3 0.017 13.7 15.0 2.4 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF3584 PF12128.8 EEA28026.1 - 0.36 8.3 35.4 0.59 7.6 35.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Vfa1 PF08432.10 EEA28026.1 - 3.6 7.9 31.8 8.6 6.6 22.1 2.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PSI_PsaF PF02507.15 EEA28026.1 - 6.3 6.6 5.0 2.5 7.9 0.3 2.5 2 1 0 2 2 2 0 Photosystem I reaction centre subunit III TPR_MLP1_2 PF07926.12 EEA28026.1 - 7.6 6.6 53.6 5 7.2 33.9 3.7 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein ATG7_N PF16420.5 EEA28027.1 - 1e-109 366.9 0.1 1.3e-109 366.5 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EEA28027.1 - 6.2e-44 150.2 0.0 9.5e-44 149.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EEA28027.1 - 0.09 12.8 0.0 0.43 10.7 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ATG7_N PF16420.5 EEA28028.1 - 6e-110 367.6 0.1 7.4e-110 367.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EEA28028.1 - 1.6e-37 129.2 0.0 2.5e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EEA28028.1 - 0.066 13.3 0.0 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase dCMP_cyt_deam_1 PF00383.23 EEA28029.1 - 7.1e-29 99.7 1.3 1.2e-28 99.0 1.3 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA28029.1 - 1.9e-12 47.1 0.3 3.5e-12 46.3 0.3 1.4 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 EEA28029.1 - 5e-05 23.8 0.0 0.00011 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 EEA28029.1 - 0.091 12.4 0.0 0.22 11.2 0.0 1.6 2 0 0 2 2 2 0 Dephospho-CoA kinase dCMP_cyt_deam_1 PF00383.23 EEA28030.1 - 7.7e-20 70.7 0.0 1.3e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA28030.1 - 1.7e-06 27.8 0.0 3.1e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 EEA28030.1 - 3.2e-05 24.5 0.0 7.4e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 EEA28030.1 - 0.063 13.0 0.0 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 Dephospho-CoA kinase His_biosynth PF00977.21 EEA28031.1 - 1.4e-48 165.4 1.2 7.2e-48 163.0 1.2 2.2 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EEA28031.1 - 1.1e-20 74.3 0.0 1.7e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EEA28031.1 - 2.1e-08 34.3 0.0 1.2e-05 25.3 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EEA28031.1 - 7.6e-07 28.9 0.0 3.2e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Dus PF01207.17 EEA28031.1 - 0.059 12.5 0.1 0.18 10.8 0.0 1.7 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) DJ-1_PfpI PF01965.24 EEA28031.1 - 0.09 12.6 0.1 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 DJ-1/PfpI family DWNN PF08783.11 EEA28032.1 - 2.9e-34 117.2 0.0 6.6e-34 116.0 0.0 1.7 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EEA28032.1 - 3.8e-08 33.0 5.0 6.8e-08 32.2 5.0 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 EEA28032.1 - 0.0013 18.5 8.1 0.0027 17.5 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.23 EEA28032.1 - 0.0021 18.1 0.7 0.0043 17.1 0.7 1.6 1 0 0 1 1 1 1 Zinc knuckle DUF966 PF06136.13 EEA28032.1 - 0.004 16.9 6.1 0.0082 15.9 6.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF966) zf-Nse PF11789.8 EEA28032.1 - 0.19 11.6 4.2 0.43 10.4 4.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Dicty_REP PF05086.12 EEA28032.1 - 0.24 9.3 6.2 0.34 8.9 6.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-RING_2 PF13639.6 EEA28032.1 - 0.34 11.3 6.9 0.74 10.2 6.9 1.6 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.6 EEA28032.1 - 0.51 10.2 5.9 1.3 8.9 5.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 EEA28032.1 - 5.7 6.9 8.7 12 5.8 8.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA28032.1 - 5.7 7.2 9.0 16 5.8 9.0 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CAML PF14963.6 EEA28032.1 - 6.1 6.9 10.5 11 6.0 10.5 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Suf PF05843.14 EEA28032.1 - 8.5 6.3 15.6 0.16 11.9 8.2 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) ODC_AZ PF02100.17 EEA28033.1 - 4.2e-32 110.5 0.0 7e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Yippee-Mis18 PF03226.14 EEA28033.1 - 1.1e-22 80.2 0.9 6.7e-22 77.7 0.6 2.1 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Transp_Tc5_C PF04236.15 EEA28033.1 - 0.0087 16.4 0.0 0.29 11.5 0.0 2.7 2 0 0 2 2 2 1 Tc5 transposase C-terminal domain Ribosomal_S27e PF01667.17 EEA28033.1 - 0.3 10.8 1.5 9 6.1 0.1 2.6 2 0 0 2 2 2 0 Ribosomal protein S27 SHNi-TPR PF10516.9 EEA28034.1 - 2e-10 39.9 0.9 2e-10 39.9 0.9 3.0 3 0 0 3 3 3 1 SHNi-TPR MIT PF04212.18 EEA28034.1 - 0.033 14.2 1.1 0.033 14.2 1.1 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Ribosomal_L29 PF00831.23 EEA28034.1 - 0.035 14.1 1.1 0.23 11.5 0.8 2.6 2 0 0 2 2 2 0 Ribosomal L29 protein TPR_12 PF13424.6 EEA28034.1 - 0.27 11.5 3.1 5.4 7.4 0.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Snapin_Pallidin PF14712.6 EEA28034.1 - 0.7 10.3 6.8 0.6 10.6 0.9 3.3 3 1 0 3 3 3 0 Snapin/Pallidin TPR_11 PF13414.6 EEA28034.1 - 2.6 7.8 5.1 13 5.6 1.2 3.1 3 0 0 3 3 3 0 TPR repeat TPR_3 PF07720.12 EEA28034.1 - 8.9 6.4 10.8 0.72 9.9 0.6 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ABC_tran_CTD PF16326.5 EEA28034.1 - 9.4 6.6 13.6 4.2 7.7 1.2 3.9 3 0 0 3 3 3 0 ABC transporter C-terminal domain DNA_pol_E_B PF04042.16 EEA28035.1 - 6.8e-48 162.8 0.0 9e-48 162.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B AIG1 PF04548.16 EEA28035.1 - 0.24 10.7 0.1 0.49 9.7 0.1 1.4 1 0 0 1 1 1 0 AIG1 family TRP PF06011.12 EEA28036.1 - 2e-140 468.3 16.0 2.5e-140 468.0 16.0 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EEA28036.1 - 7.9e-39 133.2 0.7 1.4e-38 132.4 0.7 1.5 1 0 0 1 1 1 1 ML-like domain Hep_59 PF07052.11 EEA28037.1 - 1e-20 74.4 3.2 1e-20 74.4 3.2 3.2 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 Actin PF00022.19 EEA28038.1 - 1.7e-149 497.9 0.0 1.9e-149 497.8 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EEA28038.1 - 0.00032 19.6 0.0 0.71 8.6 0.0 3.0 3 0 0 3 3 3 2 MreB/Mbl protein UDG PF03167.19 EEA28040.1 - 8e-23 81.1 0.1 1.4e-22 80.3 0.1 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Thioredoxin PF00085.20 EEA28041.1 - 1.9e-62 207.7 1.4 1.9e-30 104.9 0.0 4.2 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EEA28041.1 - 1.9e-47 161.6 0.3 1.1e-36 126.5 0.2 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Calsequestrin PF01216.17 EEA28041.1 - 7e-10 38.5 0.8 2.4e-09 36.8 0.8 1.7 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_8 PF13905.6 EEA28041.1 - 3.6e-08 33.6 0.1 0.059 13.7 0.0 4.1 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EEA28041.1 - 7.5e-08 32.8 0.3 0.0084 16.6 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 EEA28041.1 - 2.1e-07 30.9 0.1 0.0043 17.0 0.0 3.2 3 0 0 3 3 3 2 AhpC/TSA family OST3_OST6 PF04756.13 EEA28041.1 - 1.7e-06 27.6 0.1 0.072 12.4 0.0 3.3 2 1 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EEA28041.1 - 3.6e-06 27.1 0.0 0.034 14.3 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 EEA28041.1 - 4.6e-05 23.2 1.1 0.88 9.3 0.1 3.6 3 0 0 3 3 3 2 Redoxin ERp29_N PF07912.13 EEA28041.1 - 0.0079 16.3 0.0 9.3 6.4 0.0 3.3 4 0 0 4 4 4 1 ERp29, N-terminal domain Thioredoxin_4 PF13462.6 EEA28041.1 - 1.5 8.9 7.0 19 5.3 1.7 4.2 3 2 1 4 4 4 0 Thioredoxin ATG22 PF11700.8 EEA28042.1 - 2.5e-199 662.8 10.2 2.9e-199 662.6 10.2 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EEA28042.1 - 1.4e-10 40.7 45.4 6.9e-10 38.4 14.9 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 EEA28042.1 - 0.00045 18.9 27.7 0.001 17.7 3.6 2.8 2 1 0 2 2 2 2 MFS/sugar transport protein Med14 PF08638.11 EEA28043.1 - 8.5e-65 217.8 0.2 1.4e-64 217.1 0.2 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 RRM_1 PF00076.22 EEA28044.1 - 4.7e-34 116.0 0.2 9.8e-16 57.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA28044.1 - 2.7e-11 43.4 0.3 0.00025 21.1 0.0 3.0 3 1 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 EEA28044.1 - 0.0076 16.3 0.0 2.2 8.4 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 EEA28044.1 - 0.018 15.0 0.0 4.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF2201_N PF13203.6 EEA28044.1 - 0.14 11.7 5.3 0.24 11.0 5.3 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain TFIIA PF03153.13 EEA28044.1 - 2.6 8.0 19.7 3.5 7.5 19.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RabGAP-TBC PF00566.18 EEA28046.1 - 9.2e-52 175.8 0.0 3.6e-51 173.8 0.0 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PRP1_N PF06424.12 EEA28047.1 - 7.5e-52 175.7 8.7 7.5e-52 175.7 8.7 2.2 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_19 PF14559.6 EEA28047.1 - 5.1e-23 81.4 12.8 7.6e-06 26.4 0.2 9.3 6 2 3 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 EEA28047.1 - 5.8e-23 79.6 35.3 8.6e-05 23.0 0.4 12.7 4 3 9 13 13 13 6 Tetratricopeptide repeat TPR_2 PF07719.17 EEA28047.1 - 6.1e-12 44.7 9.5 0.029 14.5 0.0 8.2 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EEA28047.1 - 9.7e-12 44.1 1.0 0.21 11.9 0.0 7.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA28047.1 - 2.3e-08 34.5 19.0 0.0027 18.3 0.0 6.6 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EEA28047.1 - 2.6e-07 30.2 6.1 0.02 14.7 0.0 5.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA28047.1 - 8.4e-06 25.4 8.5 2.2 8.0 0.1 6.5 6 1 1 7 7 7 2 TPR repeat TPR_17 PF13431.6 EEA28047.1 - 1.1e-05 25.5 3.1 12 6.6 0.0 7.8 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EEA28047.1 - 6.6e-05 23.0 3.4 0.26 11.5 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EEA28047.1 - 0.00014 21.2 23.2 0.00027 20.3 9.5 4.9 3 3 0 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 EEA28047.1 - 0.0028 17.4 13.5 0.29 10.8 0.7 4.1 2 1 2 4 4 4 2 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 EEA28047.1 - 0.0038 17.5 6.9 0.12 12.7 0.1 5.8 7 1 0 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA28047.1 - 0.0044 17.0 0.2 7.8 6.8 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA28047.1 - 0.0063 16.7 2.0 2.5 8.4 0.0 4.4 3 1 2 5 5 4 1 Anaphase-promoting complex, cyclosome, subunit 3 ZNRF_3_ecto PF18212.1 EEA28047.1 - 0.02 14.9 0.2 18 5.4 0.0 4.3 5 0 0 5 5 5 0 ZNRF-3 Ectodomain Suf PF05843.14 EEA28047.1 - 0.12 12.3 2.7 10 6.0 0.1 3.6 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Wzy_C_2 PF11846.8 EEA28047.1 - 0.43 10.5 6.1 44 3.9 0.1 4.7 4 2 1 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal DUF3808 PF10300.9 EEA28047.1 - 4.3 6.0 7.8 8.5 5.0 0.0 3.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3808) TPR_6 PF13174.6 EEA28047.1 - 6.8 7.6 10.7 61 4.6 0.1 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat SAGA-Tad1 PF12767.7 EEA28048.1 - 2.2e-56 191.2 0.0 3.2e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit FUSC_2 PF13515.6 EEA28049.1 - 1.5e-31 109.1 10.0 1.5e-31 109.1 10.0 3.3 2 1 1 3 3 3 2 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EEA28049.1 - 0.0014 18.5 0.5 0.0028 17.5 0.1 1.7 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC PF04632.12 EEA28049.1 - 0.042 12.4 15.8 1.4 7.3 0.0 4.0 4 0 0 4 4 4 0 Fusaric acid resistance protein family ALMT PF11744.8 EEA28049.1 - 0.29 9.9 20.6 2.5 6.8 0.0 3.8 3 1 0 3 3 3 0 Aluminium activated malate transporter WD40 PF00400.32 EEA28050.1 - 2.5e-32 110.4 26.6 4.9e-05 24.0 0.2 10.2 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28050.1 - 9e-21 74.0 3.9 3.2e-07 30.6 0.0 6.7 4 3 4 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA28050.1 - 3.3e-06 26.3 1.3 1 8.2 0.0 5.3 4 2 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EEA28050.1 - 0.00011 22.5 0.0 4.3 8.0 0.0 5.4 4 0 0 4 4 4 1 PQQ-like domain PD40 PF07676.12 EEA28050.1 - 0.0017 18.3 10.1 3.3 7.7 0.0 6.6 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EEA28050.1 - 0.0026 17.2 0.7 4.8 6.4 0.0 3.8 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal WD40_3 PF15911.5 EEA28050.1 - 0.008 16.2 0.0 8 6.6 0.0 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EEA28050.1 - 0.025 13.8 0.0 0.072 12.3 0.0 1.8 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus WD40_like PF17005.5 EEA28050.1 - 0.066 12.5 0.0 0.89 8.8 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain SdiA-regulated PF06977.11 EEA28050.1 - 0.23 10.6 0.0 1.1 8.4 0.0 2.2 3 0 0 3 3 3 0 SdiA-regulated Proteasome_A_N PF10584.9 EEA28050.1 - 0.72 9.6 3.6 74 3.2 0.0 4.4 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Ribosomal_S18 PF01084.20 EEA28051.1 - 1.5e-14 53.9 0.2 7.6e-14 51.7 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S18 PPR_2 PF13041.6 EEA28052.1 - 4.1e-05 23.7 0.0 0.45 10.8 0.0 3.2 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 EEA28052.1 - 0.0085 16.1 0.0 39 4.4 0.0 4.3 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR PF01535.20 EEA28052.1 - 0.074 13.3 0.6 3.3 8.2 0.1 3.1 2 0 0 2 2 2 0 PPR repeat PPR_1 PF12854.7 EEA28052.1 - 0.3 10.8 1.0 9.2 6.1 0.2 3.2 3 0 0 3 3 3 0 PPR repeat ELFV_dehydrog PF00208.21 EEA28053.1 - 3.1e-68 230.1 0.0 4.7e-68 229.5 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EEA28053.1 - 5.8e-18 63.9 0.0 5.8e-12 44.0 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EEA28053.1 - 0.011 15.6 0.0 0.051 13.4 0.0 2.1 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain AGTRAP PF06396.11 EEA28053.1 - 0.094 12.5 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) ELFV_dehydrog PF00208.21 EEA28054.1 - 3.2e-68 230.1 0.0 4.9e-68 229.5 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EEA28054.1 - 6.5e-18 63.8 0.1 6.1e-12 44.0 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EEA28054.1 - 0.011 15.6 0.0 0.053 13.4 0.0 2.1 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain AGTRAP PF06396.11 EEA28054.1 - 0.089 12.6 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) TFIIIC_sub6 PF10419.9 EEA28055.1 - 1.1e-21 76.5 0.0 1.8e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain Vps62 PF06101.11 EEA28056.1 - 8.2e-11 40.9 1.0 1.3e-10 40.3 1.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Shikimate_dh_N PF08501.11 EEA28057.1 - 2e-11 44.0 0.0 3.7e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain MFS_1 PF07690.16 EEA28058.1 - 2.9e-35 121.8 53.9 1.5e-34 119.5 34.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28058.1 - 3.6e-13 49.2 5.3 3.6e-13 49.2 5.3 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EEA28058.1 - 0.0001 21.7 3.5 0.0001 21.7 3.5 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB LPD38 PF18857.1 EEA28058.1 - 0.012 15.8 0.0 0.057 13.6 0.0 2.0 2 0 0 2 2 2 0 Large polyvalent protein associated domain 38 Zn_clus PF00172.18 EEA28059.1 - 1.9e-05 24.7 9.7 3.2e-05 24.0 9.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl-CoA_dh_1 PF00441.24 EEA28060.1 - 8.4e-23 81.2 0.5 4.1e-22 79.0 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA28060.1 - 5.5e-11 43.1 0.0 1.7e-10 41.6 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA28060.1 - 9.7e-06 25.7 0.0 1.8e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cupin_8 PF13621.6 EEA28061.1 - 1.9e-09 37.6 0.0 6.9e-09 35.8 0.0 2.0 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EEA28061.1 - 2.3e-08 34.4 0.1 2.2e-07 31.3 0.1 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase JHD PF17811.1 EEA28061.1 - 2.9e-08 34.2 0.2 7.2e-08 32.9 0.2 1.7 1 0 0 1 1 1 1 Jumonji helical domain PHD PF00628.29 EEA28061.1 - 5.2e-08 32.7 7.3 5.2e-08 32.7 7.3 2.6 3 0 0 3 3 3 1 PHD-finger PHD_2 PF13831.6 EEA28061.1 - 0.019 14.5 5.8 0.019 14.5 3.6 2.3 2 0 0 2 2 2 0 PHD-finger Cupin_1 PF00190.22 EEA28061.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.7 1 0 0 1 1 1 0 Cupin RRM_1 PF00076.22 EEA28062.1 - 5.4e-18 64.6 0.4 9.5e-18 63.8 0.4 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA28062.1 - 1.3e-05 24.8 0.0 1.5e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA28062.1 - 0.032 14.1 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Rad10 PF03834.14 EEA28062.1 - 0.13 12.3 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) STIMATE PF12400.8 EEA28063.1 - 4.6e-40 137.1 6.1 8.7e-40 136.2 6.1 1.4 1 0 0 1 1 1 1 STIMATE family TMEM43 PF07787.12 EEA28063.1 - 1.9 7.8 3.9 3.2 7.1 3.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 ANAPC4_WD40 PF12894.7 EEA28064.1 - 4.6e-06 26.8 0.0 2.2 8.6 0.0 4.9 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA28064.1 - 9.6e-06 26.3 1.4 0.11 13.4 0.0 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EEA28064.1 - 0.14 10.9 0.0 0.35 9.6 0.0 1.6 2 0 0 2 2 2 0 Nup133 N terminal like TLP1_add_C PF18313.1 EEA28065.1 - 1e-23 83.1 0.1 1.8e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 Thiolase-like protein type 1 additional C-terminal domain Peptidase_S10 PF00450.22 EEA28066.1 - 5.1e-91 306.2 2.3 6.9e-91 305.7 2.3 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_1 PF00561.20 EEA28067.1 - 1.6e-17 64.0 0.1 1.2e-16 61.2 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA28067.1 - 1.9e-13 51.6 0.0 2.5e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA28067.1 - 1.5e-12 47.3 0.0 2e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 ECH_1 PF00378.20 EEA28068.1 - 8.1e-49 166.2 0.0 1.1e-48 165.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EEA28068.1 - 1.3e-27 97.2 0.1 6.7e-23 81.7 0.1 2.5 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EEA28068.1 - 0.00072 19.5 0.0 0.01 15.8 0.0 2.1 1 1 1 2 2 2 1 Peptidase family S49 SDH_sah PF01972.16 EEA28068.1 - 0.055 12.4 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Serine dehydrogenase proteinase MM_CoA_mutase PF01642.22 EEA28068.1 - 0.069 11.7 0.0 0.093 11.3 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase Hexokinase_2 PF03727.16 EEA28069.1 - 2.9e-82 275.7 0.0 4e-82 275.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EEA28069.1 - 2.7e-72 242.9 0.0 3.5e-72 242.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EEA28070.1 - 2.1e-82 276.2 0.0 2.7e-82 275.8 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EEA28070.1 - 4e-61 206.4 0.0 5.4e-61 206.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase SIR2 PF02146.17 EEA28071.1 - 6.2e-55 185.8 0.0 9e-55 185.3 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EEA28071.1 - 0.072 12.8 0.0 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain COG4 PF08318.12 EEA28072.1 - 1.2e-122 409.2 0.0 1.7e-122 408.7 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein Ammonium_transp PF00909.21 EEA28073.1 - 7.3e-115 383.8 26.6 8.4e-115 383.6 26.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF2946 PF11162.8 EEA28073.1 - 8e-05 23.3 1.0 0.02 15.6 0.3 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF2946) E1-E2_ATPase PF00122.20 EEA28074.1 - 9e-46 155.7 0.3 9e-46 155.7 0.3 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EEA28074.1 - 5.1e-42 143.6 4.0 5.7e-42 143.5 0.2 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EEA28074.1 - 2.3e-21 77.0 0.9 8e-20 72.0 0.9 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA28074.1 - 2.7e-20 71.8 0.0 6.3e-20 70.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EEA28074.1 - 3.4e-12 46.3 0.0 6.6e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA28074.1 - 1.4e-05 25.0 2.1 2.9e-05 23.9 0.5 2.3 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Rad21_Rec8_N PF04825.13 EEA28075.1 - 6.6e-38 129.3 0.1 1.4e-37 128.2 0.1 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EEA28075.1 - 1.1e-09 37.5 0.1 2.8e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein DUF4231 PF14015.6 EEA28076.1 - 0.25 11.8 1.9 15 6.1 1.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) MFS_1 PF07690.16 EEA28077.1 - 1.8e-41 142.2 37.1 3.8e-40 137.9 30.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EEA28078.1 - 1.3e-35 122.9 26.6 1.7e-35 122.6 26.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA28078.1 - 8.7e-05 21.1 1.8 0.00013 20.6 1.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Flavokinase PF01687.17 EEA28079.1 - 6.7e-31 106.9 0.0 1.9e-30 105.4 0.0 1.6 1 1 0 1 1 1 1 Riboflavin kinase Zn_clus PF00172.18 EEA28080.1 - 0.016 15.3 9.2 0.016 15.3 9.2 1.7 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 EEA28080.1 - 0.16 12.0 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 PAS fold Indigoidine_A PF04227.12 EEA28081.1 - 4.2e-122 407.1 0.4 5.7e-122 406.6 0.4 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EEA28081.1 - 1.3e-17 64.1 0.1 4.5e-08 32.7 0.0 2.7 2 0 0 2 2 2 2 pfkB family carbohydrate kinase Ribophorin_I PF04597.14 EEA28082.1 - 1.3e-153 512.3 0.2 1.5e-153 512.2 0.2 1.0 1 0 0 1 1 1 1 Ribophorin I VTC PF09359.10 EEA28084.1 - 2.5e-100 335.4 0.0 4.5e-100 334.6 0.0 1.4 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 EEA28084.1 - 2.9e-14 53.2 3.3 4.2e-13 49.5 3.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 EEA28084.1 - 1.4e-10 41.6 17.0 2.6e-05 24.3 0.2 3.9 3 1 1 4 4 4 3 SPX domain RCR PF12273.8 EEA28084.1 - 0.038 14.7 0.1 0.078 13.6 0.1 1.5 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red TauE PF01925.19 EEA28084.1 - 0.14 11.7 0.6 0.23 11.1 0.6 1.2 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE MCM PF00493.23 EEA28085.1 - 3.7e-102 340.2 0.0 5.4e-102 339.6 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA28085.1 - 7.8e-39 132.4 0.8 1.5e-38 131.5 0.8 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA28085.1 - 1.4e-28 99.2 2.9 3.1e-28 98.0 2.9 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA28085.1 - 4e-17 62.7 0.2 4.8e-16 59.2 0.1 2.8 2 1 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 EEA28085.1 - 2.1e-06 27.8 0.0 7.7e-06 25.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EEA28085.1 - 5.1e-06 26.0 0.0 0.00016 21.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EEA28085.1 - 0.00082 19.2 0.0 0.0022 17.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2252 PF10009.9 EEA28085.1 - 0.058 12.4 1.5 1 8.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) Sigma54_activat PF00158.26 EEA28085.1 - 0.15 11.8 0.1 4.7 6.9 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_16 PF13191.6 EEA28085.1 - 0.57 10.5 3.2 1.8 9.0 0.0 3.0 2 2 0 2 2 2 0 AAA ATPase domain RSN1_7TM PF02714.15 EEA28086.1 - 1.3e-83 280.4 27.4 1.3e-83 280.4 27.4 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EEA28086.1 - 4.1e-43 146.9 1.0 4.1e-43 146.9 1.0 3.6 3 1 1 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EEA28086.1 - 1.1e-27 97.4 3.5 5.5e-18 65.8 0.1 2.8 2 1 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EEA28086.1 - 4.9e-13 49.1 0.1 2.2e-12 47.0 0.0 2.2 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter CSTF2_hinge PF14327.6 EEA28087.1 - 2.8e-32 111.0 1.2 2.8e-32 111.0 1.2 2.5 4 0 0 4 4 4 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 EEA28087.1 - 1.4e-19 69.7 0.0 2.1e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 EEA28087.1 - 9.7e-17 60.3 14.6 9.7e-17 60.3 14.6 2.4 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_occluded PF16842.5 EEA28087.1 - 0.013 15.4 0.0 0.038 13.9 0.0 1.7 1 1 0 1 1 1 0 Occluded RNA-recognition motif RRM_7 PF16367.5 EEA28087.1 - 0.016 15.4 0.1 0.81 9.9 0.0 2.4 1 1 1 2 2 2 0 RNA recognition motif Spo7_2_N PF15407.6 EEA28087.1 - 0.025 14.2 0.0 0.074 12.7 0.0 1.8 2 0 0 2 2 2 0 Sporulation protein family 7 RRM_Rrp7 PF17799.1 EEA28087.1 - 0.088 12.6 0.0 8.4 6.2 0.0 2.2 1 1 1 2 2 2 0 Rrp7 RRM-like N-terminal domain RRM_5 PF13893.6 EEA28087.1 - 0.18 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Band_7 PF01145.25 EEA28088.1 - 1.2e-21 77.5 6.7 2.4e-21 76.5 6.7 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family Ank_4 PF13637.6 EEA28089.1 - 0.025 15.1 0.1 22 5.8 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeats (many copies) SNF2_N PF00176.23 EEA28090.1 - 3.1e-16 59.1 0.0 1.4e-10 40.5 0.0 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain DNA_methylase PF00145.17 EEA28090.1 - 5.2e-12 45.8 0.0 5.2e-12 45.8 0.0 3.1 5 0 0 5 5 5 1 C-5 cytosine-specific DNA methylase Helicase_C PF00271.31 EEA28090.1 - 8.8e-05 22.8 0.0 0.00017 21.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EEA28090.1 - 0.0012 18.7 8.8 0.0012 18.7 8.8 2.7 2 0 0 2 2 2 1 zinc-RING finger domain FYVE PF01363.21 EEA28090.1 - 0.054 13.7 11.9 0.29 11.3 6.9 2.9 2 0 0 2 2 2 0 FYVE zinc finger Prok-RING_4 PF14447.6 EEA28090.1 - 0.14 12.0 11.6 0.017 15.0 6.6 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EEA28090.1 - 2.5 8.2 9.0 0.81 9.8 3.4 2.6 2 0 0 2 2 2 0 RING-type zinc-finger 2Fe-2S_thioredx PF01257.19 EEA28091.1 - 2.8e-60 202.4 0.1 3.5e-60 202.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin SpoVS PF04232.12 EEA28092.1 - 0.033 13.9 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) A_deaminase PF00962.22 EEA28093.1 - 2.8e-79 266.8 0.0 3.2e-79 266.6 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase EHN PF06441.12 EEA28094.1 - 1.2e-31 109.2 0.2 2.2e-31 108.4 0.2 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EEA28094.1 - 3.9e-09 36.5 0.0 6.4e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold RHH_3 PF12651.7 EEA28094.1 - 0.019 14.9 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix domain Sua5_yciO_yrdC PF01300.18 EEA28095.1 - 9.7e-56 188.1 0.0 1.4e-55 187.5 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EEA28095.1 - 1.5e-32 112.9 0.0 2.6e-32 112.2 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Mon1 PF03164.14 EEA28097.1 - 6.2e-155 516.2 0.0 7.2e-155 516.0 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Dopey_N PF04118.14 EEA28098.1 - 3.6e-117 390.9 0.2 1.8e-116 388.5 0.0 2.4 3 0 0 3 3 3 1 Dopey, N-terminal GFO_IDH_MocA PF01408.22 EEA28099.1 - 1.1e-16 61.7 0.1 1.6e-16 61.2 0.1 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 EEA28099.1 - 0.13 12.9 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent RNaseH_pPIWI_RE PF13032.6 EEA28100.1 - 0.022 14.7 0.0 0.028 14.3 0.0 1.1 1 0 0 1 1 1 0 RNaseH domain of pPIWI_RE EHN PF06441.12 EEA28101.1 - 6.3e-25 87.7 0.1 1.1e-24 86.9 0.1 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EEA28101.1 - 1e-11 45.0 0.4 2.2e-11 43.9 0.2 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold NBD_C PF17042.5 EEA28101.1 - 0.0088 16.6 0.0 0.015 15.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-binding C-terminal domain Sugar_tr PF00083.24 EEA28102.1 - 2.2e-90 303.7 16.8 2.7e-90 303.4 16.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA28102.1 - 4.7e-27 94.8 44.1 1.3e-21 76.9 24.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EEA28102.1 - 0.0003 19.2 13.7 0.0011 17.4 5.4 3.1 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Prefoldin PF02996.17 EEA28103.1 - 0.022 14.7 1.3 0.033 14.1 1.3 1.2 1 0 0 1 1 1 0 Prefoldin subunit Retrotrans_gag PF03732.17 EEA28103.1 - 0.071 13.4 0.3 0.15 12.3 0.4 1.5 2 0 0 2 2 2 0 Retrotransposon gag protein Fib_alpha PF08702.10 EEA28103.1 - 0.076 13.2 0.9 0.11 12.7 0.6 1.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family zf-HIT PF04438.16 EEA28104.1 - 3.7e-10 39.5 9.1 6.2e-10 38.8 9.1 1.4 1 0 0 1 1 1 1 HIT zinc finger Syntaxin PF00804.25 EEA28104.1 - 0.015 15.0 1.8 0.025 14.3 1.8 1.3 1 0 0 1 1 1 0 Syntaxin Phage_NinH PF06322.11 EEA28104.1 - 0.064 13.2 0.1 0.19 11.6 0.1 1.8 1 0 0 1 1 1 0 Phage NinH protein RskA PF10099.9 EEA28104.1 - 1.4 9.2 15.7 0.31 11.3 7.5 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA MBOAT PF03062.19 EEA28105.1 - 1.7e-43 149.3 16.9 4e-33 115.2 7.8 2.3 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family PufQ PF05398.11 EEA28105.1 - 0.048 13.8 1.1 8.9 6.5 0.1 2.5 2 0 0 2 2 2 0 PufQ cytochrome subunit Hum_adeno_E3A PF05393.11 EEA28105.1 - 0.14 12.1 0.7 0.75 9.8 0.7 2.2 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein Acylphosphatase PF00708.18 EEA28106.1 - 6e-26 90.7 0.3 6.7e-26 90.5 0.3 1.0 1 0 0 1 1 1 1 Acylphosphatase BLUF PF04940.12 EEA28106.1 - 0.014 15.5 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 Sensors of blue-light using FAD Virulence_RhuM PF13310.6 EEA28106.1 - 0.099 11.9 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Virulence protein RhuM family AOX PF01786.17 EEA28107.1 - 2.3e-97 324.8 0.6 2.9e-97 324.4 0.6 1.1 1 0 0 1 1 1 1 Alternative oxidase Peptidase_S66C PF17676.1 EEA28107.1 - 0.13 12.8 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain KAR9 PF08580.10 EEA28109.1 - 2.1e-249 829.7 1.0 2.1e-249 829.7 1.0 2.1 2 0 0 2 2 2 1 Yeast cortical protein KAR9 Gemini_C4 PF01492.17 EEA28109.1 - 0.21 11.5 5.1 3.3 7.7 1.3 3.8 2 1 0 3 3 3 0 Geminivirus C4 protein Snf7 PF03357.21 EEA28109.1 - 0.53 9.9 3.5 1 8.9 0.2 2.5 1 1 0 2 2 2 0 Snf7 Spectrin PF00435.21 EEA28109.1 - 0.79 10.2 6.8 19 5.8 0.1 4.2 4 1 0 4 4 4 0 Spectrin repeat Acetyltransf_1 PF00583.25 EEA28110.1 - 0.00033 20.9 0.0 0.00046 20.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EEA28110.1 - 0.0089 16.7 0.0 0.012 16.3 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA28110.1 - 0.039 14.1 0.0 0.055 13.6 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA28110.1 - 0.065 13.7 0.0 0.13 12.7 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3682 PF12446.8 EEA28112.1 - 0.014 15.9 0.7 0.48 10.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) GATase PF00117.28 EEA28112.1 - 0.018 14.8 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase class-I TauD PF02668.16 EEA28113.1 - 1.2e-32 113.8 0.0 1.6e-32 113.3 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MafB19-deam PF14437.6 EEA28114.1 - 3.8e-12 46.1 0.0 4.4e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 EEA28114.1 - 2.3e-09 37.1 0.1 2.7e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region NAD2 PF18782.1 EEA28114.1 - 0.057 13.5 0.0 0.083 13.0 0.0 1.1 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 SNAD4 PF18750.1 EEA28114.1 - 0.074 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 Prok-RING_2 PF14445.6 EEA28114.1 - 0.09 12.9 0.1 9.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 2 APOBEC2 PF18772.1 EEA28114.1 - 0.19 11.8 0.0 0.26 11.3 0.0 1.1 1 0 0 1 1 1 0 APOBEC2 Amidase PF01425.21 EEA28115.1 - 5.5e-76 256.3 0.0 7.2e-76 255.9 0.0 1.1 1 0 0 1 1 1 1 Amidase Lactonase PF10282.9 EEA28116.1 - 4.3e-80 269.6 0.1 5.5e-80 269.2 0.1 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller PQQ_3 PF13570.6 EEA28116.1 - 0.0023 18.4 6.2 5.3 7.7 0.0 4.8 4 0 0 4 4 4 3 PQQ-like domain Helo_like_N PF17111.5 EEA28118.1 - 7.4e-20 71.2 6.6 9.6e-20 70.9 6.6 1.2 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins DUF4806 PF16064.5 EEA28118.1 - 0.071 13.4 1.2 0.78 10.1 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4806) ANAPC4_WD40 PF12894.7 EEA28119.1 - 1.4e-20 73.4 0.0 0.0012 19.2 0.0 7.6 6 2 1 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA28119.1 - 6.3e-20 71.1 10.1 1.5e-05 25.7 0.0 11.1 12 0 0 12 12 10 3 WD domain, G-beta repeat PD40 PF07676.12 EEA28119.1 - 6.5e-13 48.2 3.3 0.6 10.1 0.0 9.4 10 0 0 10 10 10 3 WD40-like Beta Propeller Repeat NACHT PF05729.12 EEA28119.1 - 3.2e-07 30.4 0.0 7.6e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA28119.1 - 4.9e-06 27.0 0.0 1.5e-05 25.4 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain Ge1_WD40 PF16529.5 EEA28119.1 - 5.4e-06 25.6 0.7 0.064 12.2 0.0 4.4 3 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EEA28119.1 - 0.0032 16.8 0.2 0.15 11.3 0.0 3.3 3 1 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 EEA28119.1 - 0.0099 14.7 0.0 0.15 10.8 0.0 2.9 3 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region ResIII PF04851.15 EEA28119.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Cytochrom_D1 PF02239.16 EEA28119.1 - 0.064 11.8 0.3 5.3 5.5 0.0 3.5 2 2 1 3 3 3 0 Cytochrome D1 heme domain KAP_NTPase PF07693.14 EEA28119.1 - 0.069 12.4 0.1 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 KAP family P-loop domain Nucleoporin_N PF08801.11 EEA28119.1 - 0.1 11.3 0.4 1.7 7.3 0.0 2.8 2 1 0 3 3 3 0 Nup133 N terminal like NB-ARC PF00931.22 EEA28119.1 - 0.12 11.6 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 EEA28119.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PQQ PF01011.21 EEA28119.1 - 0.21 11.6 0.5 35 4.6 0.0 4.1 4 0 0 4 4 3 0 PQQ enzyme repeat Proteasome_A_N PF10584.9 EEA28119.1 - 0.24 11.1 13.7 37 4.1 0.0 8.2 11 0 0 11 11 11 0 Proteasome subunit A N-terminal signature DAO PF01266.24 EEA28120.1 - 2.3e-35 122.9 0.4 3.1e-35 122.4 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Rieske PF00355.26 EEA28120.1 - 8.5e-08 32.0 0.1 2.4e-07 30.6 0.1 1.8 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain NAD_binding_8 PF13450.6 EEA28120.1 - 6.5e-05 23.1 0.7 0.00016 21.8 0.7 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA28120.1 - 0.00027 20.3 0.1 0.00046 19.5 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EEA28120.1 - 0.00037 19.7 0.3 0.0007 18.8 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA28120.1 - 0.00097 18.4 0.0 0.0017 17.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA28120.1 - 0.00099 18.4 0.2 0.0017 17.7 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EEA28120.1 - 0.0018 17.4 0.6 0.022 13.8 0.2 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 EEA28120.1 - 0.01 16.4 0.1 0.029 14.9 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA28120.1 - 0.025 13.9 0.1 0.067 12.4 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA28120.1 - 0.16 10.7 0.3 0.27 9.9 0.3 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.7 EEA28120.1 - 0.38 10.0 5.7 0.65 9.3 4.2 2.2 2 1 0 2 2 2 0 FAD dependent oxidoreductase AAA PF00004.29 EEA28121.1 - 8.7e-16 58.6 0.0 1.9e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA28121.1 - 1.4e-05 25.4 0.1 0.00014 22.1 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA28121.1 - 9.6e-05 22.8 0.1 0.00068 20.1 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EEA28121.1 - 0.0022 18.0 0.0 0.006 16.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EEA28121.1 - 0.031 14.0 0.1 0.86 9.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EEA28121.1 - 0.033 14.5 0.0 0.095 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EEA28121.1 - 0.047 13.5 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EEA28121.1 - 0.09 12.7 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 EEA28121.1 - 0.095 12.4 0.0 0.25 11.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA28121.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EEA28121.1 - 0.13 12.8 0.0 0.52 10.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 EEA28121.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Sigma54_activat PF00158.26 EEA28121.1 - 0.15 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Mito_carr PF00153.27 EEA28123.1 - 8.6e-60 198.7 0.7 1.5e-19 69.7 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein F-box-like PF12937.7 EEA28124.1 - 9.7e-09 35.0 0.0 2.1e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EEA28124.1 - 1.9e-05 24.4 0.0 4.7e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 F-box domain TPR_2 PF07719.17 EEA28124.1 - 0.02 15.0 0.7 6.1 7.2 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EEA28124.1 - 0.11 12.5 0.9 0.21 11.7 0.9 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 EEA28124.1 - 0.12 12.3 0.2 3.3 7.7 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF737 PF05300.11 EEA28124.1 - 2.7 8.3 10.0 0.12 12.7 3.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF737) HA2 PF04408.23 EEA28125.1 - 5.2e-22 78.2 0.1 1.4e-21 76.8 0.1 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA28125.1 - 1.5e-14 54.1 0.0 3.5e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA28125.1 - 1.7e-11 44.4 0.0 4.1e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA28125.1 - 0.0007 19.4 0.0 0.0024 17.7 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA28125.1 - 0.002 18.4 0.0 0.0063 16.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EEA28125.1 - 0.0032 17.2 0.0 0.0077 16.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 EEA28125.1 - 0.015 14.8 0.1 0.028 13.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EEA28125.1 - 0.018 14.9 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 EEA28125.1 - 0.019 14.3 0.2 0.068 12.5 0.0 1.9 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 EEA28125.1 - 0.025 15.1 0.0 0.064 13.8 0.0 1.7 1 0 0 1 1 1 0 ABC transporter ApbA PF02558.16 EEA28125.1 - 0.18 11.4 0.2 0.4 10.3 0.2 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Complex1_LYR_2 PF13233.6 EEA28126.1 - 5.6e-21 75.1 0.0 7.1e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EEA28126.1 - 2.9e-09 36.8 0.0 5.2e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) MTS PF05175.14 EEA28127.1 - 6.6e-05 22.5 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain rRNA_methylase PF06962.12 EEA28127.1 - 0.024 14.6 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 Putative rRNA methylase LSM PF01423.22 EEA28128.1 - 3.5e-18 65.0 0.0 4.5e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA28128.1 - 0.0011 19.0 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain F-box-like PF12937.7 EEA28129.1 - 0.00073 19.4 1.5 0.0012 18.7 0.3 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EEA28129.1 - 0.01 15.7 0.8 0.057 13.3 0.5 2.3 2 0 0 2 2 2 0 F-box domain GTP_EFTU PF00009.27 EEA28130.1 - 1.7e-07 31.0 0.0 5.5e-07 29.3 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EEA28130.1 - 0.042 13.6 0.7 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EEA28130.1 - 0.044 14.2 1.1 0.1 12.9 0.1 2.2 2 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EEA28130.1 - 0.08 12.8 0.3 5.6 6.8 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase PGM1_C PF18105.1 EEA28130.1 - 0.36 10.4 1.2 1.2 8.8 1.0 1.9 2 0 0 2 2 2 0 PGM1 C-terminal domain zf-C2H2 PF00096.26 EEA28131.1 - 1.8e-05 25.0 2.8 0.11 12.9 0.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA28131.1 - 0.00052 20.6 2.0 0.25 12.3 0.1 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger Ogr_Delta PF04606.12 EEA28131.1 - 0.14 12.2 0.6 0.28 11.2 0.6 1.5 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger Pkr1 PF08636.10 EEA28132.1 - 9.2e-31 105.8 5.6 3.3e-30 104.0 5.6 2.0 1 0 0 1 1 1 1 ER protein Pkr1 ANAPC2 PF08672.11 EEA28132.1 - 8.2e-23 80.7 0.0 4.3e-22 78.4 0.0 2.3 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 EEA28132.1 - 4.8e-21 75.0 0.9 9.5e-21 74.1 0.0 1.8 2 0 0 2 2 2 1 Cullin family Mem_trans PF03547.18 EEA28132.1 - 0.00029 19.4 0.1 0.00037 19.0 0.1 1.2 1 0 0 1 1 1 1 Membrane transport protein PduV-EutP PF10662.9 EEA28132.1 - 0.11 12.2 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation OAD_gamma PF04277.13 EEA28132.1 - 0.12 12.9 1.1 2.8 8.6 0.0 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Phage_NinH PF06322.11 EEA28132.1 - 0.15 12.0 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Phage NinH protein Presenilin PF01080.17 EEA28132.1 - 0.69 8.6 6.0 1.3 7.7 6.0 1.4 1 0 0 1 1 1 0 Presenilin Casc1_N PF15927.5 EEA28132.1 - 0.91 9.2 10.2 8 6.1 7.9 2.5 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus Kei1 PF08552.11 EEA28132.1 - 1.6 8.6 6.3 0.5 10.2 1.5 2.3 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 MFS_1 PF07690.16 EEA28133.1 - 9e-36 123.5 41.3 4.7e-35 121.2 42.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA28133.1 - 0.00077 18.9 23.6 0.001 18.4 9.4 2.2 1 1 1 2 2 2 2 Uncharacterised MFS-type transporter YbfB Orf78 PF06024.12 EEA28133.1 - 0.0075 16.6 0.0 0.02 15.2 0.0 1.7 2 0 0 2 2 2 1 Orf78 (ac78) Lambda_CIII PF02061.16 EEA28134.1 - 0.04 14.0 0.3 1.4 9.0 0.1 2.7 2 0 0 2 2 2 0 Lambda Phage CIII TraC PF07820.12 EEA28134.1 - 9.6 6.6 9.9 2.1 8.7 0.0 3.7 4 0 0 4 4 4 0 TraC-like protein Ribosomal_L16 PF00252.18 EEA28135.1 - 2.7e-43 147.1 0.1 3.6e-43 146.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e p450 PF00067.22 EEA28136.1 - 3.3e-25 88.7 0.0 6.3e-24 84.5 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EEA28138.1 - 6e-15 55.2 0.0 2.1e-10 40.4 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EEA28138.1 - 4.2e-05 23.5 0.0 6.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Ank_2 PF12796.7 EEA28139.1 - 2.3e-91 300.5 11.4 7.6e-17 61.7 0.1 8.4 2 1 8 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA28139.1 - 2.2e-60 200.3 6.5 6.5e-10 39.3 0.0 9.5 6 2 2 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28139.1 - 4.9e-57 183.2 8.2 0.0061 17.0 0.0 15.4 15 0 0 15 15 15 13 Ankyrin repeat Ank PF00023.30 EEA28139.1 - 3.8e-54 178.9 10.3 0.002 18.5 0.0 15.4 15 0 0 15 15 15 12 Ankyrin repeat Ank_5 PF13857.6 EEA28139.1 - 6.8e-53 176.0 17.5 9.5e-08 32.2 0.0 12.1 4 3 8 12 12 12 10 Ankyrin repeats (many copies) p450 PF00067.22 EEA28139.1 - 6.1e-17 61.5 0.0 1.3e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome P450 PNP_UDP_1 PF01048.20 EEA28139.1 - 3e-08 33.2 0.0 7.7e-08 31.9 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily Zn_clus PF00172.18 EEA28139.1 - 0.0016 18.6 3.2 0.0033 17.5 3.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_16 PF13191.6 EEA28139.1 - 0.16 12.3 0.0 0.55 10.6 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain HTH_Tnp_Tc3_1 PF11427.8 EEA28139.1 - 0.18 11.7 0.1 0.55 10.1 0.1 1.8 1 0 0 1 1 1 0 Tc3 transposase DUF948 PF06103.11 EEA28140.1 - 2.8 8.3 6.8 0.8 10.0 2.5 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 EEA28140.1 - 7 6.7 19.9 0.23 11.5 12.9 2.2 3 0 0 3 3 3 0 Laminin Domain II Fez1 PF06818.15 EEA28140.1 - 8.3 6.8 30.6 2 8.8 18.5 2.6 2 1 0 2 2 2 0 Fez1 Lebercilin PF15619.6 EEA28140.1 - 9.1 5.9 39.8 0.11 12.1 22.4 3.4 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 EEA28140.1 - 9.3 6.4 42.0 11 6.2 3.2 4.4 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) Clat_adaptor_s PF01217.20 EEA28141.1 - 6e-12 45.7 0.0 9.9e-11 41.7 0.3 1.9 2 0 0 2 2 2 1 Clathrin adaptor complex small chain NFACT-C PF11923.8 EEA28142.1 - 2.8e-34 117.2 0.0 2.8e-34 117.2 0.0 3.8 3 0 0 3 3 3 1 NFACT protein C-terminal domain FbpA PF05833.11 EEA28142.1 - 3.8e-33 114.9 14.4 3.8e-33 114.9 14.4 2.5 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EEA28142.1 - 1.8e-25 89.7 0.0 5e-25 88.3 0.0 1.8 1 0 0 1 1 1 1 NFACT protein RNA binding domain DEAD PF00270.29 EEA28143.1 - 2.6e-22 79.4 0.0 5.6e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA28143.1 - 1.6e-21 76.7 0.0 5.6e-19 68.5 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RQC PF09382.10 EEA28143.1 - 1.8e-17 63.2 0.0 5.5e-17 61.6 0.0 1.9 2 0 0 2 2 2 1 RQC domain RecQ_Zn_bind PF16124.5 EEA28143.1 - 5.9e-16 59.0 8.1 5.9e-16 59.0 8.1 2.0 2 0 0 2 2 2 1 RecQ zinc-binding HRDC PF00570.23 EEA28143.1 - 2.2e-08 34.0 0.0 5.5e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 EEA28143.1 - 4.1e-08 33.4 0.0 9.3e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1408 PF07193.11 EEA28143.1 - 0.13 12.4 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1408) MRP-S27 PF10037.9 EEA28143.1 - 0.17 10.7 0.9 0.29 9.9 0.9 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 CENP-K PF11802.8 EEA28144.1 - 4e-09 36.4 8.9 0.00034 20.3 7.7 2.7 2 1 1 3 3 3 2 Centromere-associated protein K DUF4407 PF14362.6 EEA28144.1 - 0.0065 15.9 4.8 0.0065 15.9 4.8 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) DUF4763 PF15960.5 EEA28144.1 - 0.022 14.1 13.8 0.31 10.3 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) Exonuc_VII_L PF02601.15 EEA28144.1 - 0.094 12.3 11.6 1.4 8.4 11.1 2.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit PA26 PF04636.13 EEA28144.1 - 0.14 11.0 1.0 0.24 10.3 1.0 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GAS PF13851.6 EEA28144.1 - 0.26 10.6 15.4 1.6 8.0 1.3 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 EEA28144.1 - 0.62 9.9 0.0 0.62 9.9 0.0 2.9 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH FliJ PF02050.16 EEA28144.1 - 0.69 10.1 13.6 0.28 11.4 2.2 2.9 3 1 0 3 3 2 0 Flagellar FliJ protein Fib_alpha PF08702.10 EEA28144.1 - 0.9 9.7 10.8 0.69 10.1 0.4 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3510 PF12022.8 EEA28144.1 - 1.5 9.2 7.5 0.25 11.7 0.2 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF3510) Rab5-bind PF09311.11 EEA28144.1 - 2.1 7.6 13.2 0.1 12.0 0.9 2.5 2 1 0 2 2 2 0 Rabaptin-like protein Fez1 PF06818.15 EEA28144.1 - 2.8 8.3 17.4 9.3 6.7 0.6 2.5 2 1 0 2 2 2 0 Fez1 CorA PF01544.18 EEA28144.1 - 3.9 6.7 8.2 8.3 5.6 7.5 2.0 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Pyridoxal_deC PF00282.19 EEA28145.1 - 3.3e-26 91.9 0.0 7.1e-26 90.8 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 EEA28145.1 - 0.0022 17.2 0.0 0.0038 16.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EEA28145.1 - 0.0056 16.0 0.0 0.0064 15.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Abhydrolase_1 PF00561.20 EEA28146.1 - 2e-16 60.4 0.0 8e-15 55.2 0.0 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA28146.1 - 2.6e-08 33.4 0.0 2.1e-07 30.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 YozE_SAM_like PF06855.12 EEA28146.1 - 0.0081 16.3 0.0 0.98 9.6 0.0 2.6 2 0 0 2 2 2 1 YozE SAM-like fold DUF4110 PF13422.6 EEA28147.1 - 1.2e-32 111.8 3.5 1.2e-32 111.8 3.5 2.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.6 EEA28147.1 - 3e-27 94.4 11.7 2e-08 34.1 0.0 6.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EEA28147.1 - 6.3e-24 83.7 11.4 3.4e-08 33.6 0.1 6.4 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EEA28147.1 - 1e-17 63.7 4.8 5.1e-06 26.4 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 EEA28147.1 - 1.8e-14 53.4 6.3 0.0041 17.4 0.1 5.3 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EEA28147.1 - 1.7e-13 49.9 0.3 0.00013 21.5 0.0 5.1 4 1 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 EEA28147.1 - 1.9e-12 46.6 7.5 0.0016 18.3 0.0 6.2 6 1 0 6 6 6 4 Kelch motif KH_1 PF00013.29 EEA28148.1 - 3.5e-43 145.3 3.9 2.2e-17 62.6 0.3 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EEA28148.1 - 1.9e-10 40.4 2.2 0.018 14.9 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EEA28148.1 - 2.3e-05 24.4 8.3 0.19 11.8 0.2 3.3 3 0 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 EEA28148.1 - 6.1e-05 22.8 0.3 0.43 10.5 0.1 3.2 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 EEA28148.1 - 0.00027 20.9 0.0 0.021 14.8 0.0 2.4 2 0 0 2 2 2 1 KH-like RNA-binding domain ABM PF03992.16 EEA28149.1 - 0.0039 17.3 0.2 4.3 7.5 0.1 2.6 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase Thioredoxin PF00085.20 EEA28151.1 - 3e-25 88.2 0.1 3.9e-25 87.8 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EEA28151.1 - 3e-07 30.7 0.2 3.1e-06 27.4 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EEA28151.1 - 8.2e-06 26.2 0.6 0.00013 22.4 0.6 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 EEA28151.1 - 8.5e-06 25.5 0.2 0.013 15.3 0.2 2.1 1 1 1 2 2 2 2 Redoxin OST3_OST6 PF04756.13 EEA28151.1 - 6.9e-05 22.3 0.0 8.7e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 EEA28151.1 - 0.0038 17.1 0.0 0.0046 16.8 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 EEA28151.1 - 0.0063 16.3 0.0 0.0081 15.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_5 PF13743.6 EEA28151.1 - 0.012 15.3 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_7 PF13899.6 EEA28151.1 - 0.016 15.4 0.8 0.052 13.7 0.8 1.8 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_4 PF13462.6 EEA28151.1 - 0.071 13.3 0.5 1.2 9.2 0.1 2.0 1 1 1 2 2 2 0 Thioredoxin Fungal_trans PF04082.18 EEA28152.1 - 6.9e-12 45.0 0.1 1.2e-11 44.2 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28152.1 - 6.5e-08 32.6 9.0 1.2e-07 31.7 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ImpA_N PF06812.12 EEA28152.1 - 0.056 13.6 0.2 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 ImpA, N-terminal, type VI secretion system NUP214 PF16755.5 EEA28153.1 - 9.7e-07 28.3 0.1 8.5e-06 25.2 0.3 2.2 2 1 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Syntaxin-6_N PF09177.11 EEA28153.1 - 0.023 15.2 0.2 0.07 13.7 0.2 1.9 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Golgin_A5 PF09787.9 EEA28153.1 - 0.069 12.6 1.1 0.13 11.7 1.1 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 ANAPC4_WD40 PF12894.7 EEA28153.1 - 0.075 13.3 0.0 0.26 11.6 0.0 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF5082 PF16888.5 EEA28153.1 - 0.9 9.8 3.1 93 3.3 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Proteasome PF00227.26 EEA28154.1 - 2.8e-45 154.1 0.0 3.5e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EEA28154.1 - 2.9e-16 58.6 0.3 2.9e-16 58.6 0.3 1.8 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Methyltransf_23 PF13489.6 EEA28156.1 - 3e-16 59.7 0.0 4.1e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA28156.1 - 1.1e-12 48.5 0.0 2.5e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA28156.1 - 1.7e-09 38.2 0.0 3.4e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA28156.1 - 1.2e-08 34.9 0.0 1.2e-07 31.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA28156.1 - 1.5e-07 32.1 0.0 6.1e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA28156.1 - 4.1e-07 29.6 0.0 1.9e-06 27.4 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EEA28156.1 - 6.4e-05 22.5 0.1 0.0014 18.1 0.0 3.0 4 0 0 4 4 4 1 Putative methyltransferase PrmA PF06325.13 EEA28156.1 - 0.0078 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EEA28156.1 - 0.0095 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_2 PF00891.18 EEA28156.1 - 0.024 13.9 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain MTS PF05175.14 EEA28156.1 - 0.11 12.0 0.0 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain DREV PF05219.12 EEA28156.1 - 0.21 10.6 0.0 0.34 10.0 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase Peptidase_M3 PF01432.20 EEA28157.1 - 4.7e-117 392.1 0.0 6.5e-117 391.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 ApoO PF09769.9 EEA28158.1 - 2e-39 134.5 1.0 8.3e-39 132.5 0.1 2.2 3 0 0 3 3 3 1 Apolipoprotein O GRASP55_65 PF04495.14 EEA28159.1 - 1.2e-41 142.2 0.0 2.9e-39 134.5 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EEA28159.1 - 0.0052 16.6 0.0 0.56 10.1 0.0 2.6 2 0 0 2 2 2 2 PDZ domain Methyltransf_15 PF09445.10 EEA28160.1 - 8.2e-51 171.9 0.0 1.1e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EEA28160.1 - 5.4e-11 42.6 0.0 8.1e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EEA28160.1 - 5.1e-07 29.5 0.0 7.5e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 EEA28160.1 - 2.6e-05 24.0 0.0 5.1e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_5 PF01795.19 EEA28160.1 - 0.00078 19.0 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family Methyltransf_25 PF13649.6 EEA28160.1 - 0.0018 18.9 0.0 0.0034 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EEA28160.1 - 0.0022 17.9 0.0 0.0036 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA28160.1 - 0.038 14.6 0.0 0.062 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EEA28160.1 - 0.05 13.1 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TRM PF02005.16 EEA28160.1 - 0.15 11.2 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltrans_SAM PF10672.9 EEA28160.1 - 0.16 11.1 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase DNA_methylase PF00145.17 EEA28160.1 - 0.21 10.9 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase DUF3591 PF12157.8 EEA28161.1 - 3.1e-178 593.0 4.2 3.9e-178 592.6 4.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 EEA28161.1 - 0.0032 17.2 0.8 0.0084 15.9 0.8 1.7 1 0 0 1 1 1 1 Zinc knuckle Pkinase PF00069.25 EEA28162.1 - 9e-46 156.4 0.0 8e-26 91.0 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28162.1 - 3.9e-18 65.7 0.0 2.4e-09 36.9 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase FKBP_C PF00254.28 EEA28163.1 - 3.4e-32 110.6 0.0 1e-31 109.1 0.0 1.9 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EEA28163.1 - 1.3e-29 102.9 3.8 1.3e-29 102.9 3.8 2.5 2 2 0 2 2 2 1 Nucleoplasmin-like domain IMS PF00817.20 EEA28164.1 - 4.5e-37 127.3 0.0 1.4e-36 125.8 0.0 1.9 2 0 0 2 2 2 1 impB/mucB/samB family REV1_C PF16727.5 EEA28164.1 - 2.3e-24 85.6 0.4 5.5e-24 84.4 0.4 1.7 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain UBM PF14377.6 EEA28164.1 - 1.6e-16 59.1 4.8 1.4e-09 37.1 1.5 4.5 4 0 0 4 4 4 2 Ubiquitin binding region IMS_C PF11799.8 EEA28164.1 - 5.6e-13 49.6 0.0 1.6e-12 48.2 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 EEA28164.1 - 3.7e-10 40.1 0.0 9.4e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EEA28164.1 - 7.3e-06 26.3 0.0 1.7e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain mCpol PF18182.1 EEA28164.1 - 0.00011 22.5 0.1 0.00055 20.3 0.1 2.1 2 0 0 2 2 2 1 minimal CRISPR polymerase domain LIG3_BRCT PF16759.5 EEA28164.1 - 0.00017 21.8 0.0 0.00037 20.7 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain IMS_HHH PF11798.8 EEA28164.1 - 0.0027 18.0 0.0 0.021 15.1 0.0 2.4 2 0 0 2 2 2 1 IMS family HHH motif PTCB-BRCT PF12738.7 EEA28164.1 - 0.005 16.7 0.0 0.024 14.6 0.0 2.2 2 0 0 2 2 2 1 twin BRCT domain DUF2267 PF10025.9 EEA28164.1 - 0.066 13.5 3.0 2 8.7 0.5 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2267) RCC_reductase PF06405.11 EEA28164.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) NAD_binding_4 PF07993.12 EEA28165.1 - 8.1e-41 139.9 0.0 1.3e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EEA28165.1 - 7.4e-26 90.7 0.0 1.4e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EEA28165.1 - 9.5e-12 44.9 0.0 1.3e-10 41.2 0.1 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA28165.1 - 7.5e-09 35.8 0.1 2e-08 34.5 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EEA28165.1 - 0.0041 16.2 0.0 0.0075 15.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA28165.1 - 0.01 15.2 0.0 0.069 12.5 0.0 2.0 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fungal_trans PF04082.18 EEA28166.1 - 1.1e-31 109.9 0.0 1.6e-31 109.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28166.1 - 2.1e-07 30.9 9.7 3.8e-07 30.1 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA28167.1 - 1.1e-31 109.9 0.0 1.6e-31 109.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28167.1 - 2.1e-07 30.9 9.7 3.8e-07 30.1 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EEA28168.1 - 4.3e-07 30.0 9.4 6.7e-07 29.3 9.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DEAD PF00270.29 EEA28169.1 - 1.8e-42 145.1 0.1 3.9e-42 144.0 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA28169.1 - 2.8e-28 98.5 0.0 2.8e-27 95.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Zip PF02535.22 EEA28169.1 - 0.83 8.8 6.0 2.8 7.1 2.5 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter CCDC117 PF15810.5 EEA28169.1 - 0.87 9.9 10.3 4.5 7.6 0.0 2.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 117 CENP-N PF05238.13 EEA28169.1 - 1.2 8.3 12.6 0.03 13.7 4.4 2.1 2 0 0 2 2 2 0 Kinetochore protein CHL4 like DUF1266 PF06889.11 EEA28169.1 - 1.8 8.6 4.8 0.58 10.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) CDC45 PF02724.14 EEA28169.1 - 2.2 6.5 15.0 1.6 6.9 5.4 2.4 2 0 0 2 2 2 0 CDC45-like protein Neur_chan_memb PF02932.16 EEA28169.1 - 7.9 6.5 11.6 1.6 8.7 2.2 2.8 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region FtsJ PF01728.19 EEA28170.1 - 2.3e-63 213.5 0.0 5e-63 212.4 0.0 1.5 2 0 0 2 2 2 1 FtsJ-like methyltransferase FAD_binding_1 PF00667.20 EEA28171.1 - 3e-65 219.9 0.0 1.1e-64 218.1 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 EEA28171.1 - 2.3e-09 37.9 0.0 1e-08 35.8 0.0 2.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR PF01558.18 EEA28171.1 - 1.3e-06 28.6 0.1 2.5e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 EEA28171.1 - 0.0002 21.6 0.1 0.00066 19.9 0.1 1.9 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II NAD_binding_10 PF13460.6 EEA28172.1 - 1.5e-06 28.3 0.0 2.5e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding HIM1 PF08732.10 EEA28172.1 - 3.7e-05 23.3 0.0 0.0001 21.9 0.0 1.6 1 1 0 1 1 1 1 HIM1 Epimerase PF01370.21 EEA28172.1 - 0.00013 21.5 0.0 0.00018 21.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EEA28172.1 - 0.009 16.5 0.1 0.056 13.9 0.0 2.0 1 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 EEA28172.1 - 0.019 14.5 0.0 0.082 12.4 0.0 1.9 1 1 0 1 1 1 0 NmrA-like family Peptidase_S41 PF03572.18 EEA28172.1 - 0.088 12.4 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S41 Proteasome PF00227.26 EEA28174.1 - 2.7e-60 203.1 0.1 3.2e-60 202.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA28174.1 - 2.6e-13 49.4 0.1 8.6e-13 47.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.14 EEA28174.1 - 0.013 15.1 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit DUF5624 PF18538.1 EEA28174.1 - 0.023 14.8 0.5 0.054 13.6 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) FF PF01846.19 EEA28175.1 - 3.1e-10 40.1 16.5 1.7e-08 34.5 0.1 3.4 4 0 0 4 4 4 2 FF domain WW PF00397.26 EEA28175.1 - 6e-09 35.8 2.5 6e-09 35.8 2.5 3.3 4 0 0 4 4 4 2 WW domain VGLL4 PF15245.6 EEA28175.1 - 0.064 13.3 1.4 0.13 12.3 1.4 1.5 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 DUF1043 PF06295.12 EEA28176.1 - 0.29 11.1 7.7 0.026 14.5 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) SAT PF16073.5 EEA28176.1 - 0.69 9.6 3.6 0.52 10.0 1.9 1.6 1 1 1 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis SPOC PF07744.13 EEA28177.1 - 1.7e-25 89.7 0.0 1.3e-24 86.8 0.0 2.2 2 0 0 2 2 2 1 SPOC domain TFIIS_M PF07500.14 EEA28177.1 - 1e-22 80.7 0.3 1e-22 80.7 0.3 2.3 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EEA28177.1 - 8.5e-11 41.6 12.2 1.5e-10 40.8 12.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.6 EEA28177.1 - 0.015 15.7 0.8 0.015 15.7 0.8 3.1 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx PHD_2 PF13831.6 EEA28177.1 - 0.021 14.4 4.3 0.038 13.5 4.3 1.4 1 0 0 1 1 1 0 PHD-finger LUC7 PF03194.15 EEA28178.1 - 7.3e-72 242.0 0.3 8.6e-72 241.8 0.3 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Occludin_ELL PF07303.13 EEA28178.1 - 0.013 16.3 0.6 1.1 10.0 0.4 2.4 2 0 0 2 2 2 0 Occludin homology domain T4SS PF07996.11 EEA28178.1 - 0.027 14.9 0.3 0.039 14.4 0.3 1.2 1 0 0 1 1 1 0 Type IV secretion system proteins TelA PF05816.11 EEA28178.1 - 0.046 12.8 0.3 0.069 12.2 0.3 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) MCPsignal PF00015.21 EEA28178.1 - 0.067 13.0 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2130 PF09903.9 EEA28178.1 - 0.071 12.4 0.1 0.13 11.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) Glutaredoxin2_C PF04399.13 EEA28178.1 - 0.087 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain HMG_box_5 PF14887.6 EEA28178.1 - 0.13 12.2 0.0 1.7 8.7 0.0 2.4 1 1 1 2 2 2 0 HMG (high mobility group) box 5 Gpi16 PF04113.14 EEA28179.1 - 9.2e-240 796.8 0.0 1.1e-239 796.6 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component CDV3 PF15359.6 EEA28181.1 - 0.4 11.2 0.1 0.4 11.2 0.1 3.9 3 1 2 5 5 5 0 Carnitine deficiency-associated protein 3 FMO-like PF00743.19 EEA28182.1 - 3.7e-17 62.0 0.2 5.6e-16 58.0 0.2 2.2 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EEA28182.1 - 4.2e-11 42.7 0.7 7.1e-07 28.8 0.6 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EEA28182.1 - 9.4e-11 41.5 0.1 2.6e-08 33.5 0.0 2.9 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA28182.1 - 4.5e-08 32.6 3.1 6.6e-06 25.5 0.1 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EEA28182.1 - 0.00026 21.5 0.2 1.3 9.7 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA28182.1 - 0.0012 18.1 0.6 0.0077 15.5 0.1 2.2 2 1 0 2 2 2 1 FAD binding domain 2-Hacid_dh_C PF02826.19 EEA28182.1 - 0.0014 18.0 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EEA28182.1 - 0.0022 18.2 0.1 0.0059 16.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EEA28182.1 - 0.013 15.9 0.0 0.53 10.8 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_9 PF13454.6 EEA28182.1 - 0.015 15.3 0.0 0.84 9.6 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding SNase PF00565.17 EEA28182.1 - 0.017 15.6 0.1 0.033 14.7 0.1 1.4 1 0 0 1 1 1 0 Staphylococcal nuclease homologue Shikimate_DH PF01488.20 EEA28182.1 - 0.031 14.3 0.1 0.16 12.0 0.1 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EEA28182.1 - 0.072 13.4 0.2 12 6.2 0.1 2.3 2 0 0 2 2 2 0 TrkA-N domain VHS PF00790.19 EEA28183.1 - 7.4e-25 87.4 0.0 1.6e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EEA28183.1 - 4e-05 23.9 0.3 9.1e-05 22.7 0.3 1.6 1 0 0 1 1 1 1 GAT domain ENTH PF01417.20 EEA28183.1 - 0.00056 20.0 0.0 0.0019 18.2 0.0 1.8 2 0 0 2 2 2 1 ENTH domain Inositol_P PF00459.25 EEA28184.1 - 1.5e-52 178.8 0.6 3.9e-52 177.4 0.6 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family Ribosomal_L6 PF00347.23 EEA28185.1 - 6.3e-25 87.7 0.1 8.4e-13 48.8 0.0 2.9 2 1 0 2 2 2 2 Ribosomal protein L6 Tht1 PF04163.12 EEA28186.1 - 1.2e-06 27.6 3.6 1.2e-06 27.6 3.6 1.8 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Spermine_synth PF01564.17 EEA28186.1 - 0.065 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Spermine/spermidine synthase domain V_ATPase_I PF01496.19 EEA28186.1 - 1.6 6.5 11.1 0.02 12.8 3.3 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF2407_C PF13373.6 EEA28186.1 - 4.3 7.5 8.7 0.36 11.0 0.9 2.7 2 1 1 3 3 3 0 DUF2407 C-terminal domain COesterase PF00135.28 EEA28187.1 - 1.5e-97 327.7 0.0 2e-97 327.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA28187.1 - 5.5e-09 36.2 0.2 8.5e-08 32.3 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA28187.1 - 0.0033 16.9 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family F-box PF00646.33 EEA28187.1 - 0.03 14.2 1.0 0.088 12.7 0.0 2.3 3 0 0 3 3 3 0 F-box domain Flavoprotein PF02441.19 EEA28188.1 - 1e-13 51.3 0.0 1.8e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein Ank_4 PF13637.6 EEA28188.1 - 1.6e-05 25.4 0.1 0.95 10.1 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeats (many copies) MFS_1 PF07690.16 EEA28189.1 - 5.7e-43 147.2 45.6 5.7e-43 147.2 45.6 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28189.1 - 1e-14 54.3 16.0 1e-14 54.3 16.0 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter UPF0767 PF15990.5 EEA28190.1 - 0.063 13.4 0.0 0.071 13.3 0.0 1.1 1 0 0 1 1 1 0 UPF0767 family UPF0767 PF15990.5 EEA28191.1 - 0.034 14.3 0.0 0.039 14.1 0.0 1.1 1 0 0 1 1 1 0 UPF0767 family APG12 PF04110.13 EEA28192.1 - 5.8e-27 93.9 0.0 8.1e-27 93.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EEA28192.1 - 0.0011 19.2 0.0 0.0014 18.8 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like UQ_con PF00179.26 EEA28193.1 - 3.5e-36 123.9 0.1 4.5e-36 123.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UQ_con PF00179.26 EEA28194.1 - 3.5e-36 123.9 0.1 4.5e-36 123.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LAMTOR PF15454.6 EEA28195.1 - 4.5e-16 59.2 0.1 9.3e-16 58.2 0.1 1.5 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF2011 PF09428.10 EEA28196.1 - 1.4e-29 102.1 2.7 1.4e-29 102.1 0.0 2.2 2 1 0 2 2 2 1 Fungal protein of unknown function (DUF2011) Pantoate_transf PF02548.15 EEA28197.1 - 4.2e-107 357.4 1.7 5.1e-107 357.1 1.7 1.1 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EEA28197.1 - 6.4e-08 32.3 2.2 1.4e-07 31.2 2.2 1.7 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Ank_2 PF12796.7 EEA28198.1 - 3.6e-111 363.9 8.2 6e-14 52.4 0.1 9.7 6 2 3 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA28198.1 - 3.6e-87 285.7 14.9 2.5e-11 43.8 0.0 14.4 7 4 7 15 15 15 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28198.1 - 6.3e-77 244.3 14.9 0.00046 20.4 0.0 19.8 19 0 0 19 19 19 17 Ankyrin repeat Ank PF00023.30 EEA28198.1 - 2.9e-74 242.5 31.4 2.8e-05 24.4 0.1 19.9 20 0 0 20 20 20 15 Ankyrin repeat Ank_5 PF13857.6 EEA28198.1 - 3.5e-61 202.5 21.3 3.1e-09 36.9 0.0 16.2 4 3 15 19 19 19 14 Ankyrin repeats (many copies) HET PF06985.11 EEA28198.1 - 1.6e-07 31.8 1.7 1.5e-05 25.4 0.1 2.5 1 1 1 2 2 2 1 Heterokaryon incompatibility protein (HET) DUF3447 PF11929.8 EEA28198.1 - 0.0068 16.3 0.0 36 4.4 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF3447) Ribosomal_L28 PF00830.19 EEA28198.1 - 0.2 11.9 0.1 0.57 10.4 0.1 1.7 1 0 0 1 1 1 0 Ribosomal L28 family DUF4792 PF16040.5 EEA28198.1 - 0.21 11.5 0.3 1.9 8.5 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4792) VWA_3_C PF18571.1 EEA28198.1 - 2 8.3 8.4 8.3 6.4 0.0 5.7 8 0 0 8 8 8 0 von Willebrand factor type A C-terminal domain Dfp1_Him1_M PF08630.10 EEA28199.1 - 1.4e-41 141.6 0.0 6.3e-41 139.5 0.0 2.2 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 EEA28199.1 - 6.7e-21 74.1 0.1 1.2e-20 73.4 0.1 1.4 1 0 0 1 1 1 1 DBF zinc finger Peptidase_M24 PF00557.24 EEA28200.1 - 3.8e-48 164.0 0.0 5.4e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EEA28200.1 - 1.6e-36 124.7 0.0 3.4e-36 123.7 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Pyridox_ox_2 PF12900.7 EEA28201.1 - 6.8e-40 136.3 0.0 9.6e-40 135.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase SIR2 PF02146.17 EEA28202.1 - 2.2e-39 135.2 0.0 7.1e-39 133.5 0.0 1.7 1 1 0 1 1 1 1 Sir2 family SNF2_N PF00176.23 EEA28203.1 - 3.6e-69 233.2 3.5 1.2e-64 218.2 0.2 3.5 3 1 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA28203.1 - 7.9e-16 58.4 0.1 4e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA28203.1 - 8.2e-09 35.7 1.1 1.6e-08 34.7 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA28203.1 - 2.2e-07 30.8 0.0 6.7e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.6 EEA28203.1 - 0.00077 18.4 0.1 0.002 17.1 0.1 1.6 1 1 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 BUD22 PF09073.10 EEA28203.1 - 0.03 13.7 32.9 0.02 14.3 18.0 2.5 2 0 0 2 2 2 0 BUD22 DEAD_2 PF06733.15 EEA28203.1 - 0.081 12.5 0.0 0.081 12.5 0.0 2.2 2 1 0 2 2 2 0 DEAD_2 SLX9 PF15341.6 EEA28203.1 - 1.6 9.1 13.7 0.89 10.0 2.6 2.9 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 Cytochrom_B558a PF05038.13 EEA28204.1 - 0.0012 18.4 0.2 0.0021 17.7 0.2 1.3 1 0 0 1 1 1 1 Cytochrome Cytochrome b558 alpha-subunit Yip1 PF04893.17 EEA28204.1 - 0.016 14.9 0.1 0.023 14.4 0.1 1.1 1 0 0 1 1 1 0 Yip1 domain HemY_N PF07219.13 EEA28204.1 - 0.038 14.2 2.2 3 8.1 0.5 2.6 2 0 0 2 2 2 0 HemY protein N-terminus S1FA PF04689.13 EEA28204.1 - 0.1 12.8 0.2 0.1 12.8 0.2 1.9 2 0 0 2 2 2 0 DNA binding protein S1FA DUF898 PF05987.13 EEA28204.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) COX14 PF14880.6 EEA28204.1 - 0.13 12.2 0.1 0.37 10.7 0.1 1.8 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DUF3302 PF11742.8 EEA28204.1 - 0.13 12.4 1.4 0.29 11.3 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3302) PHY PF00360.20 EEA28205.1 - 1e-31 109.7 0.0 2.2e-31 108.6 0.0 1.5 1 0 0 1 1 1 1 Phytochrome region Response_reg PF00072.24 EEA28205.1 - 7.1e-17 61.6 0.1 2.3e-16 60.0 0.1 1.9 1 1 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EEA28205.1 - 2e-16 60.5 0.1 5.2e-16 59.2 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.26 EEA28205.1 - 1.2e-12 48.6 0.0 4.9e-12 46.6 0.0 2.1 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 EEA28205.1 - 1.5e-11 44.1 0.6 4.2e-11 42.7 0.6 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.11 EEA28205.1 - 1e-10 42.2 0.0 3e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 EEA28205.1 - 0.1 12.4 0.1 0.22 11.3 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 EEA28205.1 - 0.11 12.4 0.5 0.28 11.1 0.0 1.9 2 0 0 2 2 2 0 GHKL domain Cellulase PF00150.18 EEA28206.1 - 7.7e-09 35.4 2.9 1.7e-08 34.3 2.9 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) EphA2_TM PF14575.6 EEA28206.1 - 2.3 9.1 0.0 2.3 9.1 0.0 3.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Pkinase PF00069.25 EEA28207.1 - 1e-61 208.6 0.0 1.5e-61 208.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28207.1 - 1.2e-32 113.3 0.0 1.6e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA28207.1 - 4e-06 26.4 0.0 6.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA28207.1 - 0.001 18.5 0.1 0.0018 17.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA28207.1 - 0.0016 18.4 1.1 0.0034 17.3 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA28207.1 - 0.014 14.4 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EEA28207.1 - 0.021 13.6 0.0 0.036 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Endonuc_Holl PF10107.9 EEA28207.1 - 0.14 12.0 0.3 1 9.2 0.0 2.0 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Ribosomal_L33 PF00471.20 EEA28208.1 - 2.6e-05 24.6 0.0 3.3e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 Abhydrolase_6 PF12697.7 EEA28210.1 - 4.9e-22 79.6 0.0 6.3e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA28210.1 - 0.0042 16.4 0.0 0.0078 15.5 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EEA28210.1 - 0.0071 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein PE-PPE PF08237.11 EEA28210.1 - 0.027 14.0 0.0 0.67 9.5 0.0 2.1 2 0 0 2 2 2 0 PE-PPE domain DUF3089 PF11288.8 EEA28210.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Palm_thioest PF02089.15 EEA28210.1 - 0.069 13.0 0.0 0.095 12.5 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase VirB8 PF04335.13 EEA28210.1 - 0.087 12.6 0.0 0.18 11.6 0.0 1.5 1 1 0 1 1 1 0 VirB8 protein Abhydrolase_8 PF06259.12 EEA28210.1 - 0.1 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_1 PF00561.20 EEA28210.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_2 PF01674.18 EEA28210.1 - 0.18 11.3 0.1 0.3 10.6 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 2) GSH_synth_ATP PF03917.17 EEA28211.1 - 2.3e-106 355.7 0.0 2.6e-106 355.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EEA28211.1 - 5.6e-24 84.6 0.0 1.2e-23 83.5 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Med13_C PF06333.12 EEA28212.1 - 7.5e-87 291.7 1.1 7.5e-87 291.7 1.1 2.4 4 0 0 4 4 4 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EEA28212.1 - 3.3e-73 246.8 0.0 6.4e-73 245.9 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EEA28212.1 - 6.5e-34 117.8 0.1 6.5e-34 117.8 0.1 3.9 2 2 0 2 2 2 1 MID domain of medPIWI NUC153 PF08159.12 EEA28213.1 - 1e-12 47.6 1.0 2.1e-12 46.6 1.0 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EEA28213.1 - 9.8e-05 23.1 0.0 41 5.3 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28213.1 - 0.12 12.7 0.0 1.6 9.1 0.0 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain ATG13 PF10033.9 EEA28214.1 - 4.3e-70 236.1 0.0 8.3e-70 235.2 0.0 1.5 1 0 0 1 1 1 1 Autophagy-related protein 13 RCC1 PF00415.18 EEA28215.1 - 1.6e-22 79.8 0.1 1e-06 29.3 0.0 6.0 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EEA28215.1 - 9.6e-16 58.0 0.2 1.3e-09 38.2 0.0 3.5 4 0 0 4 4 4 2 BTB/POZ domain RCC1_2 PF13540.6 EEA28215.1 - 1.1e-10 41.0 1.6 1.7e-08 34.0 0.1 3.6 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 EEA28215.1 - 6.5e-09 36.2 0.1 7.1e-08 32.9 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28215.1 - 5.2e-06 26.4 0.2 0.35 11.6 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EEA28215.1 - 4.4e-05 24.0 0.0 0.00013 22.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EEA28215.1 - 0.052 14.0 0.0 4.1 8.0 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat MKRN1_C PF15815.5 EEA28215.1 - 0.14 12.6 2.3 0.49 10.8 0.2 3.2 3 0 0 3 3 3 0 E3 ubiquitin-protein ligase makorin-1, C-terminal VHS PF00790.19 EEA28217.1 - 1.3e-40 138.5 2.5 5.3e-40 136.5 0.2 2.3 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 EEA28217.1 - 3e-16 59.3 1.3 4.9e-16 58.6 1.3 1.3 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 EEA28217.1 - 4.5e-06 26.2 17.5 0.0019 18.0 3.5 3.5 3 0 0 3 3 3 2 Ubiquitin interaction motif GAT PF03127.14 EEA28217.1 - 9.9e-06 25.8 0.1 6.7e-05 23.1 0.0 2.4 2 0 0 2 2 2 1 GAT domain Npa1 PF11707.8 EEA28217.1 - 0.031 13.6 0.2 0.055 12.8 0.2 1.3 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal OrfB_Zn_ribbon PF07282.11 EEA28217.1 - 0.042 13.8 1.5 1.6 8.7 3.7 2.2 2 0 0 2 2 2 0 Putative transposase DNA-binding domain FYVE_2 PF02318.16 EEA28217.1 - 0.14 12.4 0.4 0.3 11.3 0.4 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Fer4_2 PF12797.7 EEA28217.1 - 4.3 7.6 4.5 2.3 8.5 0.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Ank_5 PF13857.6 EEA28218.1 - 0.0001 22.5 1.3 21 5.6 0.0 5.2 6 0 0 6 6 6 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EEA28218.1 - 0.00061 20.3 4.9 34 5.2 0.1 5.9 4 2 2 6 6 6 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28218.1 - 0.00066 19.9 4.4 2.2 9.1 0.1 6.0 7 0 0 7 7 7 1 Ankyrin repeat Ank PF00023.30 EEA28218.1 - 0.0028 18.0 4.5 5.7 7.6 0.0 5.2 6 0 0 6 6 6 1 Ankyrin repeat UCH PF00443.29 EEA28219.1 - 4.3e-54 183.7 0.0 8.6e-54 182.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA28219.1 - 3.8e-15 56.3 0.1 2.5e-12 47.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 EEA28219.1 - 0.00015 21.9 0.4 0.00036 20.7 0.0 1.8 2 0 0 2 2 2 1 USP8 dimerisation domain Rhodanese PF00581.20 EEA28219.1 - 0.001 19.5 0.0 0.0023 18.4 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Cyt-b5 PF00173.28 EEA28220.1 - 1.1e-21 76.8 0.2 1.3e-21 76.5 0.2 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Mito_carr PF00153.27 EEA28221.1 - 5e-53 177.0 6.5 2.3e-19 69.1 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein KH_1 PF00013.29 EEA28222.1 - 5.3e-99 324.1 30.8 1.2e-12 47.4 0.3 15.2 15 1 0 15 15 15 9 KH domain SLS PF14611.6 EEA28222.1 - 2.3e-15 57.0 9.6 0.23 11.2 0.0 7.6 4 3 2 7 7 7 6 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 EEA28222.1 - 5.3e-13 48.6 21.4 0.025 14.4 0.1 7.7 7 0 0 7 7 7 4 KH domain KH_4 PF13083.6 EEA28222.1 - 0.00054 19.8 0.3 38 4.3 0.0 5.2 4 0 0 4 4 4 0 KH domain YbbR PF07949.12 EEA28222.1 - 0.00079 19.7 2.2 11 6.4 0.1 6.3 8 0 0 8 8 8 1 YbbR-like protein KH_5 PF13184.6 EEA28222.1 - 1.5 9.0 15.9 28 4.9 0.0 6.8 7 1 1 8 8 8 0 NusA-like KH domain NACHT_N PF17100.5 EEA28223.1 - 9.7e-34 117.1 3.2 9.7e-34 117.1 3.2 2.4 2 0 0 2 2 2 1 N-terminal domain of NWD NACHT-NTPase Ank_2 PF12796.7 EEA28223.1 - 3.8e-27 94.7 0.0 1.5e-05 25.5 0.0 4.9 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EEA28223.1 - 2.5e-24 84.6 0.1 0.00023 21.5 0.2 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EEA28223.1 - 1.5e-22 79.7 0.0 5.5e-07 30.0 0.0 5.7 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28223.1 - 2e-22 76.8 0.1 0.00032 20.9 0.0 6.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EEA28223.1 - 9.1e-19 67.3 0.1 0.00069 19.9 0.0 5.9 5 1 1 6 6 6 4 Ankyrin repeats (many copies) NACHT PF05729.12 EEA28223.1 - 2.6e-06 27.4 0.1 8.5e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 EEA28223.1 - 0.021 15.0 4.2 0.23 11.6 0.1 3.2 4 0 0 4 4 4 0 AAA domain KAP_NTPase PF07693.14 EEA28223.1 - 0.051 12.8 1.0 24 4.0 0.4 3.3 3 0 0 3 3 3 0 KAP family P-loop domain LINES_C PF14695.6 EEA28223.1 - 0.081 12.4 0.5 0.41 10.1 0.1 2.5 2 0 0 2 2 2 0 Lines C-terminus AAA_22 PF13401.6 EEA28223.1 - 0.12 12.7 0.0 0.64 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain KIAA1430 PF13879.6 EEA28223.1 - 1.5 9.6 4.6 5.5 7.8 4.6 2.0 1 0 0 1 1 1 0 KIAA1430 homologue Lig_chan PF00060.26 EEA28224.1 - 1 9.2 3.9 13 5.7 0.0 2.5 3 0 0 3 3 3 0 Ligand-gated ion channel Pkinase PF00069.25 EEA28226.1 - 1.6e-72 244.0 0.0 1.6e-72 244.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28226.1 - 4.8e-45 153.9 0.0 4.8e-45 153.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 EEA28226.1 - 1.8e-20 73.1 0.1 1.8e-20 73.1 0.1 3.2 3 0 0 3 3 2 1 P21-Rho-binding domain Kinase-like PF14531.6 EEA28226.1 - 7.2e-07 28.8 0.0 1.7e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA28226.1 - 1.1e-06 27.7 0.0 1.1e-06 27.7 0.0 2.8 3 1 0 3 3 2 1 Fungal protein kinase Kdo PF06293.14 EEA28226.1 - 0.016 14.5 0.5 0.075 12.4 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_23 PF13476.6 EEA28226.1 - 0.037 14.5 5.0 0.099 13.1 5.0 1.7 1 0 0 1 1 1 0 AAA domain DUF4471 PF14740.6 EEA28226.1 - 0.16 11.2 4.9 0.027 13.7 1.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) NARP1 PF12569.8 EEA28226.1 - 0.22 10.4 4.9 0.42 9.5 4.9 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 APH PF01636.23 EEA28226.1 - 0.33 10.8 0.1 0.33 10.8 0.1 3.2 3 1 1 4 4 4 0 Phosphotransferase enzyme family FTA2 PF13095.6 EEA28226.1 - 0.55 9.8 0.0 0.55 9.8 0.0 2.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DSHCT PF08148.12 EEA28226.1 - 0.67 9.6 0.0 0.67 9.6 0.0 2.1 2 0 0 2 2 2 0 DSHCT (NUC185) domain V_ATPase_I PF01496.19 EEA28226.1 - 2.5 5.9 5.5 4.4 5.1 5.5 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ribosomal_L37 PF08561.10 EEA28226.1 - 3.5 8.2 11.3 0.077 13.5 2.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 VHS PF00790.19 EEA28227.1 - 1.2e-35 122.4 0.8 2.1e-35 121.6 0.8 1.4 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 EEA28227.1 - 4.3e-17 61.5 0.1 3.8e-16 58.4 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EEA28227.1 - 1.2e-14 53.9 0.0 2.4e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EEA28227.1 - 2.1e-14 52.9 0.0 4e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EEA28227.1 - 2.8e-10 40.3 3.2 4.2e-10 39.8 1.0 2.4 2 0 0 2 2 2 1 GAT domain UIM PF02809.20 EEA28227.1 - 0.021 14.7 2.3 0.065 13.2 2.3 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif Hrs_helical PF12210.8 EEA28227.1 - 0.073 13.6 0.1 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate UCH_1 PF13423.6 EEA28228.1 - 1.8e-97 326.8 0.1 2.5e-97 326.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EEA28228.1 - 2.4e-15 57.5 0.0 5.3e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EEA28228.1 - 0.00047 19.7 0.0 0.0013 18.3 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GTP_EFTU PF00009.27 EEA28229.1 - 2.2e-50 170.9 0.0 5e-50 169.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EEA28229.1 - 4.5e-18 65.3 6.4 9.2e-18 64.3 6.4 1.5 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 EEA28229.1 - 2.3e-09 37.5 0.0 7.3e-09 35.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EEA28229.1 - 2.5e-08 34.0 0.2 3.5e-06 27.1 0.0 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EEA28229.1 - 2.7e-06 27.6 0.0 9e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Gtr1_RagA PF04670.12 EEA28229.1 - 0.00059 19.3 0.0 0.0012 18.2 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EEA28229.1 - 0.0079 15.6 0.0 1.1 8.6 0.0 2.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EEA28229.1 - 0.0087 16.0 1.3 0.23 11.3 0.2 2.7 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EEA28229.1 - 0.0099 15.4 0.3 0.38 10.3 0.2 2.9 2 1 0 2 2 2 1 Ferrous iron transport protein B Roc PF08477.13 EEA28229.1 - 0.041 14.1 0.0 11 6.3 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EEA28229.1 - 0.052 12.7 0.2 1.9 7.6 0.1 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Acyltransf_C PF16076.5 EEA28229.1 - 0.062 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Acyltransferase C-terminus Septin PF00735.18 EEA28229.1 - 0.085 12.1 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Septin Arf PF00025.21 EEA28229.1 - 0.085 12.3 0.0 7.8 5.9 0.0 2.3 1 1 1 2 2 2 0 ADP-ribosylation factor family HSP70 PF00012.20 EEA28230.1 - 2.5e-262 871.5 10.7 2.8e-262 871.3 10.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA28230.1 - 2.8e-17 62.5 0.9 4.5e-16 58.6 0.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.10 EEA28230.1 - 0.0027 16.8 0.6 0.017 14.1 0.3 2.0 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FIVAR PF07554.13 EEA28230.1 - 0.11 13.3 0.3 18 6.2 0.1 3.3 3 0 0 3 3 3 0 FIVAR domain Hydantoinase_A PF01968.18 EEA28230.1 - 0.36 10.0 4.4 0.57 9.4 0.1 2.8 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase FtsA PF14450.6 EEA28230.1 - 0.76 10.2 7.5 18 5.8 0.3 3.7 3 2 0 3 3 3 0 Cell division protein FtsA Haem_degrading PF03928.14 EEA28231.1 - 4.7e-35 120.2 0.1 6.1e-35 119.9 0.1 1.1 1 0 0 1 1 1 1 Haem-degrading Bys1 PF04681.12 EEA28232.1 - 4e-12 46.3 0.3 4.8e-12 46.1 0.3 1.0 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Ion_trans PF00520.31 EEA28233.1 - 8.2e-05 21.9 5.2 0.00012 21.4 5.2 1.2 1 0 0 1 1 1 1 Ion transport protein CdvA PF18822.1 EEA28233.1 - 0.016 15.0 1.0 0.026 14.4 1.0 1.3 1 0 0 1 1 1 0 CdvA-like coiled-coil domain Herpes_BLRF2 PF05812.12 EEA28233.1 - 0.046 13.8 0.4 0.078 13.1 0.4 1.3 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein bZIP_2 PF07716.15 EEA28233.1 - 0.054 13.6 0.7 0.13 12.4 0.7 1.6 1 0 0 1 1 1 0 Basic region leucine zipper Phage_Mu_Gam PF07352.12 EEA28233.1 - 0.066 13.1 0.7 0.12 12.3 0.7 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Fe-ADH PF00465.19 EEA28234.1 - 2.2e-103 345.9 0.0 2.7e-103 345.6 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EEA28234.1 - 1.5e-15 57.6 0.0 2.7e-11 43.6 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EEA28234.1 - 0.0037 17.0 0.0 0.0067 16.1 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein Fungal_trans_2 PF11951.8 EEA28235.1 - 1.2e-07 31.0 0.0 2.4e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28235.1 - 1.8e-06 28.0 11.6 4.3e-06 26.8 11.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EEA28236.1 - 3e-13 49.4 35.7 7.4e-11 41.6 10.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily COX8 PF02285.15 EEA28236.1 - 0.0043 16.9 0.2 3 7.8 0.0 2.7 2 0 0 2 2 2 2 Cytochrome oxidase c subunit VIII Tmem26 PF09772.9 EEA28236.1 - 0.039 13.3 0.0 0.057 12.8 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 26 Fungal_trans PF04082.18 EEA28237.1 - 1.4e-16 60.4 0.0 3.1e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28237.1 - 1e-07 32.0 12.1 1.6e-07 31.3 12.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EST1_DNA_bind PF10373.9 EEA28237.1 - 0.073 12.5 0.8 0.6 9.5 0.0 2.4 2 1 0 2 2 2 0 Est1 DNA/RNA binding domain Glyoxalase PF00903.25 EEA28238.1 - 1e-38 132.4 0.0 4.8e-19 68.8 0.0 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EEA28238.1 - 2.8e-16 59.7 0.0 1.2e-07 32.0 0.0 4.3 1 1 3 4 4 4 4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EEA28238.1 - 1.3e-05 25.9 0.0 0.14 12.9 0.0 2.8 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EEA28238.1 - 0.00059 20.0 0.0 2 8.5 0.0 3.0 1 1 2 3 3 3 3 Glyoxalase-like domain DUF1338 PF07063.13 EEA28238.1 - 0.008 15.4 0.3 16 4.6 0.0 3.7 2 2 1 3 3 3 2 Domain of unknown function (DUF1338) Glyoxalase_2 PF12681.7 EEA28238.1 - 0.0083 16.0 1.1 3.3 7.7 0.0 3.6 4 0 0 4 4 4 1 Glyoxalase-like domain MoaF PF10703.9 EEA28238.1 - 0.026 14.4 0.0 0.83 9.6 0.0 2.4 2 0 0 2 2 2 0 MoaF N-terminal domain Acetyltransf_3 PF13302.7 EEA28241.1 - 1.8e-11 44.9 0.0 2.7e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA28241.1 - 1.5e-05 25.2 0.0 2.5e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EEA28241.1 - 0.0028 17.8 0.0 0.0047 17.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA28241.1 - 0.021 15.2 0.0 0.038 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EEA28241.1 - 0.048 13.3 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DNA_primase_lrg PF04104.14 EEA28241.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit PH PF00169.29 EEA28242.1 - 0.016 15.7 0.0 0.03 14.8 0.0 1.5 1 0 0 1 1 1 0 PH domain INO80_Ies4 PF08193.11 EEA28242.1 - 0.042 13.8 8.1 0.074 13.0 8.1 1.3 1 0 0 1 1 1 0 INO80 complex subunit Ies4 Apolipoprotein PF01442.18 EEA28242.1 - 0.14 12.0 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Rib_recp_KP_reg PF05104.12 EEA28242.1 - 3.5 8.7 9.3 6.7 7.7 9.3 1.4 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Arrestin_C PF02752.22 EEA28243.1 - 1.3e-18 67.8 0.0 3.8e-18 66.2 0.1 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EEA28243.1 - 1.6e-08 34.8 0.0 2.9e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Zds_C PF08632.10 EEA28245.1 - 7e-29 99.4 0.6 1.2e-28 98.6 0.6 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term TFIIA PF03153.13 EEA28245.1 - 0.094 12.7 45.3 0.4 10.6 13.9 3.0 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Ysc84 PF04366.12 EEA28246.1 - 9.1e-43 145.1 0.4 1.6e-42 144.3 0.4 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EEA28246.1 - 1.5e-13 50.1 0.2 4.4e-13 48.6 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EEA28246.1 - 2e-11 43.4 0.1 7.1e-11 41.6 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EEA28246.1 - 1.5e-10 40.7 0.0 3.1e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain EF_assoc_2 PF08356.12 EEA28247.1 - 8.3e-35 118.7 0.0 1.6e-34 117.8 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EEA28247.1 - 6.7e-31 105.7 0.3 1.2e-30 104.9 0.3 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EEA28247.1 - 3.1e-26 91.9 0.0 6.9e-14 51.8 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EEA28247.1 - 7e-14 52.1 0.0 5.4e-08 33.1 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EEA28247.1 - 4.3e-09 36.5 0.0 0.00021 21.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 EEA28247.1 - 2.4e-05 23.6 2.8 0.067 12.8 0.5 2.6 2 0 0 2 2 2 2 EF hand AAA_16 PF13191.6 EEA28247.1 - 3.7e-05 24.2 0.5 0.18 12.2 0.1 3.1 3 1 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA28247.1 - 4.3e-05 23.5 0.3 2 8.3 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EEA28247.1 - 6.3e-05 22.6 0.4 0.043 13.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain EF-hand_6 PF13405.6 EEA28247.1 - 6.9e-05 22.5 2.3 0.03 14.3 0.5 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EEA28247.1 - 0.00018 21.9 0.8 0.036 14.5 0.2 2.6 2 0 0 2 2 2 1 EF-hand domain pair Dynamin_N PF00350.23 EEA28247.1 - 0.00024 21.2 0.4 0.66 10.0 0.2 2.6 2 1 0 2 2 2 2 Dynamin family AAA_22 PF13401.6 EEA28247.1 - 0.00052 20.3 0.5 1.6 9.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 EEA28247.1 - 0.0023 17.5 0.1 4 6.9 0.0 3.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EEA28247.1 - 0.0028 18.2 0.0 2 8.9 0.0 2.5 2 0 0 2 2 2 1 ABC transporter Viral_helicase1 PF01443.18 EEA28247.1 - 0.005 16.6 0.2 0.15 11.8 0.0 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase EF-hand_10 PF14788.6 EEA28247.1 - 0.007 16.2 2.3 0.069 13.0 0.5 2.5 2 0 0 2 2 2 1 EF hand AAA_28 PF13521.6 EEA28247.1 - 0.011 16.0 0.2 8.6 6.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 EEA28247.1 - 0.011 14.9 0.1 2.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 EEA28247.1 - 0.021 15.3 0.0 1.6 9.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EEA28247.1 - 0.023 15.1 0.0 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 EEA28247.1 - 0.027 14.4 0.8 9.9 6.1 0.1 2.8 2 1 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 EEA28247.1 - 0.03 14.1 0.1 0.43 10.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA28247.1 - 0.04 13.5 0.1 13 5.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EEA28247.1 - 0.048 13.2 0.1 1.7 8.1 0.0 2.4 2 1 0 2 2 2 0 P-loop containing dynein motor region Septin PF00735.18 EEA28247.1 - 0.069 12.4 0.1 0.8 8.9 0.1 2.2 2 0 0 2 2 2 0 Septin EF-hand_5 PF13202.6 EEA28247.1 - 0.08 12.5 5.8 1.3 8.6 0.4 2.6 2 0 0 2 2 2 0 EF hand ATP_bind_1 PF03029.17 EEA28247.1 - 0.1 12.3 2.0 15 5.3 0.0 3.1 2 1 0 3 3 3 0 Conserved hypothetical ATP binding protein IIGP PF05049.13 EEA28247.1 - 0.14 11.2 0.7 1.5 7.8 0.1 2.2 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Ploopntkinase3 PF18751.1 EEA28247.1 - 0.2 11.6 0.0 22 4.9 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 EF-hand_8 PF13833.6 EEA28247.1 - 0.23 11.4 0.7 23 4.9 0.2 2.6 2 0 0 2 2 2 0 EF-hand domain pair AAA_23 PF13476.6 EEA28247.1 - 0.25 11.8 0.4 14 6.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain ANAPC4_WD40 PF12894.7 EEA28248.1 - 2.6e-11 43.7 0.2 0.011 16.0 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA28248.1 - 6.3e-10 39.5 14.2 0.00045 21.0 0.7 5.6 5 1 0 5 5 5 3 WD domain, G-beta repeat IKI3 PF04762.12 EEA28248.1 - 1.6e-05 23.2 0.0 0.00044 18.4 0.0 2.0 1 1 1 2 2 2 2 IKI3 family Cytochrom_D1 PF02239.16 EEA28248.1 - 0.0016 17.1 0.0 0.005 15.4 0.0 1.8 2 1 0 2 2 2 1 Cytochrome D1 heme domain Nup160 PF11715.8 EEA28248.1 - 0.0019 17.0 0.0 0.0037 16.0 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 eIF2A PF08662.11 EEA28248.1 - 0.0067 16.3 0.0 0.048 13.5 0.0 2.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A ArfGap PF01412.18 EEA28249.1 - 6.8e-41 139.0 1.0 1e-40 138.4 1.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf SelR PF01641.18 EEA28250.1 - 8.2e-49 164.7 0.0 1.3e-48 164.1 0.0 1.3 1 0 0 1 1 1 1 SelR domain MCM_OB PF17207.3 EEA28250.1 - 0.045 13.6 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 MCM OB domain zinc_ribbon_10 PF10058.9 EEA28250.1 - 0.1 12.4 0.2 0.78 9.5 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 EEA28250.1 - 0.7 10.0 3.3 15 5.7 0.4 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EEA28250.1 - 2.2 7.8 5.2 4.3 6.9 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain CUE PF02845.16 EEA28251.1 - 6.3e-08 32.2 0.0 1.3e-05 24.8 0.0 2.7 2 0 0 2 2 2 2 CUE domain DUF1771 PF08590.10 EEA28251.1 - 1.5e-07 31.6 7.5 3.1e-07 30.7 7.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 EEA28251.1 - 0.0001 22.6 0.1 0.00038 20.8 0.1 1.9 2 0 0 2 2 2 1 Smr domain HBS1_N PF08938.10 EEA28251.1 - 0.0074 16.6 0.0 0.023 15.0 0.0 1.9 1 0 0 1 1 1 1 HBS1 N-terminus GPI-anchored PF10342.9 EEA28252.1 - 1.4e-16 61.0 0.9 1.4e-16 61.0 0.9 2.6 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Macoilin PF09726.9 EEA28252.1 - 0.97 7.9 10.1 1 7.9 10.1 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EEA28252.1 - 2.3 6.9 9.5 2.9 6.7 9.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 EEA28252.1 - 5.5 6.3 5.4 6.3 6.1 5.4 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Amnionless PF14828.6 EEA28252.1 - 5.6 5.7 8.9 4.8 5.9 4.3 2.0 1 1 1 2 2 2 0 Amnionless RAP1 PF07218.11 EEA28252.1 - 6.1 5.0 16.7 6.6 4.9 16.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAP1 PF08601.10 EEA28252.1 - 6.2 6.5 16.6 6.9 6.3 16.6 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 zf_ZIC PF18366.1 EEA28253.1 - 0.00058 19.9 0.1 0.0015 18.6 0.1 1.6 1 0 0 1 1 1 1 Zic proteins zinc finger domain RFX_DNA_binding PF02257.15 EEA28253.1 - 0.056 14.1 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 RFX DNA-binding domain zf-C2H2 PF00096.26 EEA28253.1 - 0.069 13.6 0.2 0.21 12.1 0.2 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type PDGF PF00341.17 EEA28253.1 - 0.079 13.3 0.0 0.29 11.5 0.0 2.0 1 0 0 1 1 1 0 PDGF/VEGF domain Arm PF00514.23 EEA28253.1 - 0.085 12.9 2.0 4.9 7.4 0.1 3.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Zn_clus PF00172.18 EEA28255.1 - 1.8e-10 40.8 8.9 3.1e-10 40.0 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF111 PF01969.17 EEA28255.1 - 0.1 11.7 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF111 Spt20 PF12090.8 EEA28255.1 - 0.2 11.3 9.4 0.38 10.3 9.4 1.4 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 EEA28255.1 - 3.1 6.4 6.2 5.1 5.7 6.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EEA28255.1 - 9 4.9 5.9 14 4.3 5.9 1.2 1 0 0 1 1 1 0 Presenilin Copper-fist PF00649.18 EEA28256.1 - 3.5e-21 74.4 2.4 3.5e-21 74.4 2.4 1.9 2 0 0 2 2 2 1 Copper fist DNA binding domain Pex14_N PF04695.13 EEA28256.1 - 0.0076 16.9 1.2 0.015 16.0 1.2 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Aminotran_1_2 PF00155.21 EEA28257.1 - 4.9e-40 137.8 0.0 7.4e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II RPN7 PF10602.9 EEA28258.1 - 5.8e-56 188.9 0.6 9e-56 188.3 0.6 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EEA28258.1 - 1.5e-13 51.1 0.0 3.6e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 PCI domain LigB PF02900.18 EEA28258.1 - 0.0068 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase TPR_7 PF13176.6 EEA28258.1 - 0.021 14.8 0.0 0.092 12.8 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Acetyltransf_1 PF00583.25 EEA28259.1 - 1.2e-08 35.2 0.0 1.5e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA28259.1 - 1.1e-06 28.6 0.0 1.5e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA28259.1 - 2.4e-05 24.7 0.0 3.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA28259.1 - 0.0013 18.9 0.0 0.0018 18.4 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Sugar_tr PF00083.24 EEA28260.1 - 2.6e-34 118.9 29.5 2.2e-21 76.3 10.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EEA28260.1 - 4.5e-17 62.0 58.8 3.8e-16 59.0 35.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PEX11 PF05648.14 EEA28261.1 - 5.3e-72 241.9 0.2 5.9e-72 241.7 0.2 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Na_H_Exchanger PF00999.21 EEA28262.1 - 2.3e-46 158.3 8.4 2.9e-46 158.0 8.4 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Virul_fac_BrkB PF03631.15 EEA28262.1 - 0.021 14.4 3.2 4.6 6.8 0.0 2.8 1 1 0 2 2 2 0 Virulence factor BrkB YrhC PF14143.6 EEA28262.1 - 0.025 14.7 2.4 0.25 11.5 0.4 3.2 3 0 0 3 3 3 0 YrhC-like protein Lys_export PF03956.13 EEA28262.1 - 0.2 11.2 3.7 0.071 12.6 0.5 1.8 2 0 0 2 2 2 0 Lysine exporter LysO Tfb4 PF03850.14 EEA28263.1 - 2.5e-119 397.8 0.9 3e-119 397.6 0.9 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 UNC45-central PF11701.8 EEA28264.1 - 6.3e-48 162.6 1.7 2.6e-47 160.6 0.4 2.8 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central TPR_15 PF13429.6 EEA28264.1 - 0.013 14.7 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA28264.1 - 0.034 14.2 1.0 0.079 13.1 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat GDPD PF03009.17 EEA28265.1 - 6e-72 242.5 0.0 1.3e-71 241.4 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_4 PF13637.6 EEA28265.1 - 3.6e-26 91.2 2.5 9e-12 45.3 0.1 5.2 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA28265.1 - 6.5e-26 90.7 0.1 5.3e-10 39.7 0.3 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) SPX PF03105.19 EEA28265.1 - 6.5e-24 85.6 4.5 6.6e-12 46.0 0.0 3.6 2 1 1 3 3 3 3 SPX domain Ank_5 PF13857.6 EEA28265.1 - 1.2e-16 60.5 0.6 3.1e-07 30.5 0.1 5.9 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28265.1 - 7.3e-16 56.7 1.0 0.028 14.9 0.0 7.3 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 EEA28265.1 - 1.1e-13 51.0 4.7 0.00012 22.3 0.0 6.2 5 1 0 5 5 5 3 Ankyrin repeat DUF3322 PF11795.8 EEA28265.1 - 0.21 11.6 1.2 9.5 6.2 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) PRMT5_TIM PF17285.2 EEA28266.1 - 4.1e-74 249.0 0.0 5.4e-74 248.6 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 EEA28266.1 - 3.1e-66 222.5 0.0 4.8e-66 221.9 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EEA28266.1 - 2.2e-54 184.0 0.0 4.5e-54 183.0 0.0 1.6 1 0 0 1 1 1 1 PRMT5 oligomerisation domain OB_NTP_bind PF07717.16 EEA28267.1 - 1.7e-22 79.6 0.1 4.5e-22 78.2 0.1 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EEA28267.1 - 6.4e-20 71.5 0.0 1.6e-19 70.2 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EEA28267.1 - 1.1e-10 41.9 0.0 3.8e-10 40.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA28267.1 - 2.3e-08 34.0 0.2 4.3e-08 33.1 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA28267.1 - 6.6e-07 29.7 0.0 2.5e-06 27.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EEA28267.1 - 7.6e-05 22.4 0.3 0.00025 20.7 0.3 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EEA28267.1 - 0.00067 20.0 0.1 0.0013 19.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EEA28267.1 - 0.0016 18.4 0.2 0.0031 17.5 0.2 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 EEA28267.1 - 0.004 16.9 0.0 0.0068 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EEA28267.1 - 0.011 14.9 0.0 0.031 13.3 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 EEA28267.1 - 0.04 13.4 0.0 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EEA28267.1 - 0.068 12.9 0.1 2 8.1 0.1 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 EEA28267.1 - 0.11 13.0 0.0 0.21 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EEA28267.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) CLZ PF16526.5 EEA28268.1 - 0.14 12.5 1.3 15 6.1 0.4 2.9 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels APG6_N PF17675.1 EEA28268.1 - 0.21 12.1 2.1 0.3 11.6 0.5 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4140 PF13600.6 EEA28268.1 - 0.22 12.0 3.1 2.9 8.4 0.3 2.7 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) SlyX PF04102.12 EEA28268.1 - 0.4 11.3 2.0 31 5.3 0.2 2.8 2 0 0 2 2 2 0 SlyX EF-hand_6 PF13405.6 EEA28269.1 - 1.4e-05 24.6 0.1 0.041 13.8 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EEA28269.1 - 0.0063 16.9 0.5 0.015 15.8 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EEA28269.1 - 0.057 13.0 0.0 1.7 8.4 0.0 2.5 2 0 0 2 2 2 0 EF hand DUF1845 PF08900.11 EEA28269.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1845) Met_10 PF02475.16 EEA28270.1 - 0.0007 19.4 0.0 0.0032 17.2 0.0 2.1 1 1 0 1 1 1 1 Met-10+ like-protein Mito_carr PF00153.27 EEA28271.1 - 1.1e-44 150.2 1.3 4.6e-20 71.4 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Pkinase PF00069.25 EEA28272.1 - 1.3e-46 159.1 0.0 2.8e-43 148.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28272.1 - 4e-21 75.5 0.0 7e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA28272.1 - 0.0095 15.9 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA28272.1 - 0.039 12.9 0.0 0.039 12.9 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EEA28272.1 - 0.081 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EEA28272.1 - 0.13 11.9 0.0 3.7 7.1 0.0 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PP-binding PF00550.25 EEA28273.1 - 1.4e-05 25.3 0.0 4e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 EEA28274.1 - 5.3e-38 130.4 0.0 8.5e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28274.1 - 1e-34 120.1 0.0 2.4e-34 118.9 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA28274.1 - 1.3e-11 44.8 0.1 2.6e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EEA28274.1 - 0.07 12.9 0.9 0.19 11.5 0.9 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Ribosomal_L11 PF00298.19 EEA28275.1 - 4.4e-27 94.4 0.1 6.8e-27 93.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EEA28275.1 - 1.7e-26 91.8 0.1 2.9e-26 91.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain DUF3613 PF12266.8 EEA28275.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3613) Svf1_C PF17187.4 EEA28276.1 - 1.7e-61 206.9 0.1 1.3e-60 203.9 0.0 2.1 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EEA28276.1 - 1.1e-53 181.6 0.0 2.1e-53 180.7 0.0 1.5 2 0 0 2 2 2 1 Svf1-like N-terminal lipocalin domain T4-Gluco-transf PF09198.10 EEA28277.1 - 0.052 13.2 0.3 0.12 12.0 0.1 1.8 1 1 1 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase Acetyltransf_1 PF00583.25 EEA28278.1 - 0.00045 20.4 0.0 0.001 19.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Pho86 PF11124.8 EEA28278.1 - 0.0069 15.9 0.2 0.0098 15.4 0.2 1.2 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 DUF4491 PF14898.6 EEA28278.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4491) Acetyltransf_9 PF13527.7 EEA28278.1 - 0.14 12.2 0.2 25 4.9 0.1 3.0 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain DHC_N1 PF08385.12 EEA28279.1 - 6e-126 421.3 6.9 6e-126 421.3 6.9 4.6 7 0 0 7 7 7 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 EEA28279.1 - 3.7e-125 417.2 0.0 1.9e-124 414.9 0.0 2.3 3 0 0 3 3 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EEA28279.1 - 1.6e-115 386.4 9.9 1.6e-115 386.4 9.9 4.7 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EEA28279.1 - 2e-75 252.7 1.7 2e-75 252.7 1.7 4.4 4 1 0 4 4 4 1 ATP-binding dynein motor region AAA_8 PF12780.7 EEA28279.1 - 3e-68 230.0 0.0 1.2e-67 228.0 0.0 2.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EEA28279.1 - 4e-42 143.8 0.0 7.3e-36 123.4 0.0 4.7 5 0 0 5 5 4 2 P-loop containing dynein motor region MT PF12777.7 EEA28279.1 - 2.5e-41 141.9 8.9 4.5e-41 141.0 8.9 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EEA28279.1 - 1.5e-33 115.4 0.9 1e-26 93.4 0.0 5.1 5 0 0 5 5 4 2 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 EEA28279.1 - 1.2e-31 109.6 0.7 7.1e-11 42.3 0.0 6.7 6 1 0 6 6 5 4 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 EEA28279.1 - 4.4e-27 94.9 0.0 1.1e-26 93.7 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 EEA28279.1 - 8.3e-18 64.7 0.2 1.2e-16 61.0 0.0 3.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EEA28279.1 - 3e-15 56.7 0.1 0.0098 16.2 0.0 5.9 4 0 0 4 4 4 3 AAA domain AAA PF00004.29 EEA28279.1 - 9.5e-14 51.9 0.0 0.00055 20.4 0.0 4.7 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA28279.1 - 2.1e-09 38.0 0.8 1.2 9.5 0.0 7.1 6 0 0 6 6 5 1 AAA ATPase domain AAA_33 PF13671.6 EEA28279.1 - 1.8e-08 34.7 7.9 0.13 12.5 0.0 6.0 7 0 0 7 7 5 3 AAA domain AAA_18 PF13238.6 EEA28279.1 - 5.1e-08 33.5 4.3 0.077 13.5 0.0 5.8 5 0 0 5 5 4 2 AAA domain T2SSE PF00437.20 EEA28279.1 - 4.6e-06 25.9 0.0 0.034 13.2 0.0 3.7 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_lid_1 PF17857.1 EEA28279.1 - 2.4e-05 24.5 0.2 0.0024 18.1 0.0 3.7 3 0 0 3 3 3 1 AAA+ lid domain ABC_tran PF00005.27 EEA28279.1 - 3e-05 24.5 0.1 2.7 8.5 0.0 4.9 3 0 0 3 3 3 1 ABC transporter AAA_29 PF13555.6 EEA28279.1 - 9.5e-05 22.1 0.1 2.3 8.0 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_14 PF13173.6 EEA28279.1 - 9.6e-05 22.4 0.0 2.4 8.2 0.0 4.2 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 EEA28279.1 - 0.00012 21.5 0.6 0.67 9.3 0.0 3.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 EEA28279.1 - 0.00037 19.9 0.7 1.7 7.9 0.0 3.9 4 0 0 4 4 3 1 FtsK/SpoIIIE family AAA_30 PF13604.6 EEA28279.1 - 0.00044 20.0 0.6 38 3.9 0.0 5.0 5 0 0 5 5 4 0 AAA domain AAA_19 PF13245.6 EEA28279.1 - 0.00088 19.6 1.4 0.28 11.5 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.6 EEA28279.1 - 0.0029 17.2 0.0 0.27 10.8 0.0 3.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EEA28279.1 - 0.0053 16.5 1.1 11 5.6 0.0 4.2 4 0 0 4 4 3 0 AAA domain IstB_IS21 PF01695.17 EEA28279.1 - 0.013 15.3 2.0 0.8 9.4 0.0 4.3 5 0 0 5 5 5 0 IstB-like ATP binding protein Rad17 PF03215.15 EEA28279.1 - 0.015 15.2 0.8 6.9 6.6 0.0 4.3 5 0 0 5 5 4 0 Rad17 P-loop domain RNA_helicase PF00910.22 EEA28279.1 - 0.021 15.2 0.6 71 3.9 0.0 5.0 5 0 0 5 5 4 0 RNA helicase Vps23_core PF09454.10 EEA28279.1 - 0.031 14.2 0.7 1.3 9.0 0.3 3.1 2 0 0 2 2 2 0 Vps23 core domain DUF4482 PF14818.6 EEA28279.1 - 0.078 13.8 9.2 17 6.3 0.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Hemerythrin PF01814.23 EEA28279.1 - 0.12 13.0 2.8 1.7 9.3 0.1 4.3 4 1 1 5 5 4 0 Hemerythrin HHE cation binding domain BRE1 PF08647.11 EEA28279.1 - 0.45 10.6 18.1 0.0092 16.0 2.4 4.7 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase Phage_GP20 PF06810.11 EEA28279.1 - 3.3 7.5 21.4 1.8 8.4 6.0 4.5 4 0 0 4 4 4 0 Phage minor structural protein GP20 Ribonuclease_3 PF00636.26 EEA28280.1 - 5e-42 142.8 0.0 2.1e-19 70.1 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EEA28280.1 - 1.5e-24 86.6 0.0 3.3e-12 46.7 0.0 3.9 2 2 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EEA28280.1 - 2.3e-21 75.8 0.0 1.4e-20 73.2 0.0 2.3 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 EEA28280.1 - 4.7e-17 62.3 0.1 2.6e-16 59.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA28280.1 - 8.1e-13 48.7 0.2 1.8e-12 47.6 0.2 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA28280.1 - 3.2e-09 36.8 0.0 7.4e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Barstar PF01337.18 EEA28280.1 - 0.11 12.5 0.0 0.68 10.0 0.0 2.3 2 0 0 2 2 2 0 Barstar (barnase inhibitor) TAP42 PF04177.12 EEA28281.1 - 3.6e-106 354.9 13.6 4e-106 354.7 13.6 1.0 1 0 0 1 1 1 1 TAP42-like family Terminase_4 PF05119.12 EEA28281.1 - 0.098 13.1 1.1 0.18 12.2 0.2 2.1 2 1 0 2 2 2 0 Phage terminase, small subunit DUF4477 PF14780.6 EEA28281.1 - 0.11 12.1 0.9 0.22 11.1 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) DUF4140 PF13600.6 EEA28281.1 - 3 8.3 6.0 21 5.6 0.9 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Porphobil_deam PF01379.20 EEA28282.1 - 1.8e-71 239.9 0.0 2.9e-71 239.2 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EEA28282.1 - 1.1e-13 51.4 0.0 1.9e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Lon_C PF05362.13 EEA28283.1 - 4.9e-69 232.0 0.1 1e-68 230.9 0.1 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EEA28283.1 - 3.6e-30 105.4 0.5 3.6e-30 105.4 0.5 1.9 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EEA28283.1 - 2.9e-24 86.0 0.0 3.4e-23 82.5 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA28283.1 - 1.7e-07 31.3 0.0 9.3e-07 28.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EEA28283.1 - 1.4e-06 28.2 0.0 3.6e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EEA28283.1 - 4.7e-06 27.1 0.2 2.1e-05 25.0 0.0 2.2 2 0 0 2 2 1 1 AAA ATPase domain AAA_3 PF07726.11 EEA28283.1 - 0.00017 21.4 0.0 0.001 18.9 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA28283.1 - 0.00018 21.3 0.1 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EEA28283.1 - 0.00032 20.5 0.0 0.00093 19.0 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 EEA28283.1 - 0.00043 20.6 0.1 0.0062 16.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA28283.1 - 0.0021 18.2 0.3 0.0077 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EEA28283.1 - 0.0027 17.8 0.0 0.0097 16.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EEA28283.1 - 0.0035 16.6 0.0 0.0079 15.4 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain NACHT PF05729.12 EEA28283.1 - 0.024 14.6 1.0 0.32 10.9 0.0 3.0 3 0 0 3 3 3 0 NACHT domain AAA_7 PF12775.7 EEA28283.1 - 0.029 13.9 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EEA28283.1 - 0.03 13.7 0.1 0.083 12.3 0.1 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EEA28283.1 - 0.032 13.4 0.1 2.4 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Rad17 PF03215.15 EEA28283.1 - 0.038 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_14 PF13173.6 EEA28283.1 - 0.04 13.9 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA28283.1 - 0.049 14.0 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EEA28283.1 - 0.049 14.2 0.1 0.13 12.8 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 EEA28283.1 - 0.053 12.4 0.1 0.57 9.0 0.1 2.2 2 0 0 2 2 2 0 PrkA AAA domain LmjF365940-deam PF14421.6 EEA28283.1 - 0.059 13.0 0.0 0.64 9.6 0.0 2.2 2 0 0 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases PhoH PF02562.16 EEA28283.1 - 0.065 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 EEA28283.1 - 0.086 12.5 0.1 0.25 11.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EEA28283.1 - 0.1 11.9 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 EEA28283.1 - 0.14 12.2 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EEA28283.1 - 0.48 10.9 4.3 0.51 10.9 0.1 2.8 1 1 1 2 2 2 0 ABC transporter PCRF PF03462.18 EEA28283.1 - 0.86 9.4 6.0 6.7 6.5 1.7 2.5 1 1 1 2 2 2 0 PCRF domain AAA_23 PF13476.6 EEA28283.1 - 1.3 9.5 0.0 1.3 9.5 0.0 3.1 1 1 1 2 2 1 0 AAA domain Laps PF10169.9 EEA28283.1 - 1.4 9.5 8.8 0.66 10.6 0.1 2.5 1 1 1 2 2 2 0 Learning-associated protein AAA_11 PF13086.6 EEA28283.1 - 6.4 6.5 10.3 0.22 11.3 0.1 2.4 1 1 1 2 2 1 0 AAA domain Ribosomal_L23 PF00276.20 EEA28284.1 - 2.2e-11 44.0 0.1 5.3e-11 42.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L23 AA_permease_N PF08403.10 EEA28284.1 - 0.13 11.7 0.8 0.24 10.9 0.1 1.8 2 0 0 2 2 2 0 Amino acid permease N-terminal RIO1 PF01163.22 EEA28285.1 - 6.3e-41 140.0 0.1 5.3e-29 101.2 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 EEA28285.1 - 3.9e-32 110.3 0.0 8.3e-32 109.3 0.0 1.6 1 0 0 1 1 1 1 Rio2, N-terminal Kdo PF06293.14 EEA28285.1 - 5.5e-07 29.2 0.0 3.9e-05 23.1 0.0 2.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA28285.1 - 4.9e-06 26.6 0.0 0.03 14.2 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family NOA36 PF06524.12 EEA28285.1 - 0.52 9.6 11.4 0.76 9.1 11.4 1.2 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 EEA28285.1 - 2.2 7.6 14.6 3.2 7.0 14.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RPN1_RPN2_N PF17781.1 EEA28286.1 - 4.4e-118 394.2 2.4 7.8e-118 393.4 2.4 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EEA28286.1 - 1.6e-29 101.7 0.0 2.9e-29 100.9 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EEA28286.1 - 2.6e-16 59.1 16.5 6.1e-05 23.3 0.1 7.7 8 0 0 8 8 8 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EEA28286.1 - 4.1e-05 23.9 0.4 1.3 9.4 0.0 4.8 4 2 1 5 5 5 3 HEAT repeats AbbA_antirepres PF14156.6 EEA28286.1 - 0.015 15.1 0.3 0.58 10.1 0.1 3.2 2 0 0 2 2 2 0 Antirepressor AbbA DUF4691 PF15762.5 EEA28286.1 - 0.029 14.5 0.6 0.051 13.7 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4691) TPR_12 PF13424.6 EEA28286.1 - 0.1 12.9 1.0 5.3 7.4 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Mlh1_C PF16413.5 EEA28287.1 - 2.3e-103 345.3 0.0 1.4e-102 342.7 0.0 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EEA28287.1 - 3.2e-33 113.9 0.2 5.9e-33 113.1 0.2 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EEA28287.1 - 5.9e-13 48.8 0.0 1.2e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EEA28287.1 - 2e-07 31.5 0.0 5.5e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DSPc PF00782.20 EEA28288.1 - 2.6e-29 101.7 0.0 3e-20 72.4 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA28288.1 - 1.1e-05 25.1 0.0 0.00071 19.2 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EEA28288.1 - 0.063 13.4 0.0 0.3 11.2 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate Cupin_8 PF13621.6 EEA28289.1 - 2.8e-45 155.0 0.0 4.4e-45 154.4 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Kelch_4 PF13418.6 EEA28289.1 - 1.6e-25 88.8 1.4 2e-06 27.7 0.1 5.7 5 0 0 5 5 5 5 Galactose oxidase, central domain LCM PF04072.14 EEA28289.1 - 9.9e-23 81.1 0.0 1.9e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_5 PF13854.6 EEA28289.1 - 1.4e-16 60.1 5.2 2.7e-06 27.2 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EEA28289.1 - 2.1e-05 24.7 2.2 0.0008 19.6 0.1 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Cupin_4 PF08007.12 EEA28289.1 - 0.00048 19.7 0.0 0.0011 18.5 0.0 1.6 1 0 0 1 1 1 1 Cupin superfamily protein Kelch_6 PF13964.6 EEA28289.1 - 0.0029 17.8 2.9 1.7 9.1 0.0 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 EEA28289.1 - 0.83 9.7 13.1 2.2 8.4 0.0 4.7 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 EEA28290.1 - 0.00058 20.6 0.1 0.31 12.0 0.0 4.1 3 1 1 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28290.1 - 0.001 19.3 0.0 0.68 10.3 0.0 3.9 2 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain CNH PF00780.22 EEA28290.1 - 0.0057 16.3 0.1 10 5.6 0.1 3.0 2 1 1 3 3 3 3 CNH domain Hira PF07569.11 EEA28290.1 - 0.022 14.5 0.0 0.81 9.4 0.0 2.9 3 0 0 3 3 3 0 TUP1-like enhancer of split Coatomer_WDAD PF04053.14 EEA28290.1 - 0.048 12.7 0.0 0.14 11.2 0.0 1.8 2 0 0 2 2 2 0 Coatomer WD associated region Cupin_5 PF06172.11 EEA28291.1 - 4e-49 166.4 0.0 5.1e-49 166.1 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) DUF3337 PF11816.8 EEA28292.1 - 1.4e-55 187.8 0.0 1.4e-55 187.8 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EEA28292.1 - 1.9e-07 31.7 4.7 3.4e-05 24.5 0.2 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28292.1 - 0.031 14.6 0.1 0.43 10.9 0.0 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3337 PF11816.8 EEA28293.1 - 2.8e-40 138.0 1.0 3.7e-40 137.6 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EEA28293.1 - 1.6e-07 31.9 4.7 3.1e-05 24.6 0.2 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28293.1 - 0.043 14.1 0.0 0.37 11.1 0.1 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA28293.1 - 0.17 10.8 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ATP_bind_3 PF01171.20 EEA28294.1 - 5.9e-43 146.7 0.0 1.7e-42 145.2 0.0 1.8 1 1 0 1 1 1 1 PP-loop family Acetyltransf_3 PF13302.7 EEA28294.1 - 0.13 13.0 0.0 0.29 11.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SspO PF08175.12 EEA28294.1 - 1.1 9.7 4.8 0.5 10.9 2.0 1.9 2 0 0 2 2 2 0 Small acid-soluble spore protein O family RhoGEF PF00621.20 EEA28295.1 - 2.8e-22 79.9 0.9 7.8e-22 78.4 0.1 2.1 2 0 0 2 2 2 1 RhoGEF domain DUF3507 PF12015.8 EEA28295.1 - 5.3e-05 23.0 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) Nod1 PF17114.5 EEA28295.1 - 0.049 13.8 0.0 0.29 11.3 0.0 2.4 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 SHE3 PF17078.5 EEA28295.1 - 0.051 13.3 5.5 0.15 11.7 5.4 1.9 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 SesA PF17107.5 EEA28295.1 - 0.13 12.5 4.2 0.16 12.2 1.1 2.7 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Phage_GP20 PF06810.11 EEA28295.1 - 0.3 10.9 3.1 0.37 10.6 0.4 2.2 2 0 0 2 2 2 0 Phage minor structural protein GP20 Syntaxin PF00804.25 EEA28295.1 - 0.43 10.2 9.6 5.9 6.5 0.1 3.5 2 1 0 2 2 2 0 Syntaxin Spc7 PF08317.11 EEA28295.1 - 3.3 6.5 8.4 13 4.6 0.6 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Sec7 PF01369.20 EEA28296.1 - 8.6e-61 204.8 0.0 1.4e-60 204.1 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EEA28296.1 - 6.6e-18 65.1 0.0 8.4e-17 61.5 0.0 2.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_14 PF13428.6 EEA28297.1 - 1.6e-13 50.2 7.7 3.6 8.6 0.2 10.9 11 2 2 13 13 11 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA28297.1 - 1.8e-08 34.0 5.1 0.34 11.2 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat Suf PF05843.14 EEA28297.1 - 7.2e-08 32.8 14.6 0.11 12.4 2.4 6.5 3 2 1 5 5 5 4 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 EEA28297.1 - 7.2e-08 32.5 12.6 0.067 13.2 0.0 7.2 5 3 1 6 6 6 2 Mad3/BUB1 homology region 1 TPR_19 PF14559.6 EEA28297.1 - 1.4e-05 25.5 0.0 27 5.4 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA28297.1 - 0.00012 22.3 6.7 5.3 7.4 0.0 6.7 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA28297.1 - 0.00048 20.0 17.6 3.4 8.0 0.0 7.7 9 0 0 9 9 9 2 Tetratricopeptide repeat MIT PF04212.18 EEA28297.1 - 0.045 13.8 0.0 2 8.6 0.1 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain NRDE-2 PF08424.10 EEA28297.1 - 0.063 12.4 0.1 0.063 12.4 0.1 6.3 2 2 5 7 7 7 0 NRDE-2, necessary for RNA interference HAT PF02184.16 EEA28297.1 - 0.18 11.8 6.3 2.9 8.0 0.0 5.2 5 0 0 5 5 5 0 HAT (Half-A-TPR) repeat TPR_10 PF13374.6 EEA28297.1 - 0.94 9.4 6.0 1.3e+02 2.6 0.4 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EEA28297.1 - 7.9 7.1 12.9 13 6.5 0.1 6.7 9 0 0 9 9 7 0 Tetratricopeptide repeat ATP-synt_D PF01813.17 EEA28298.1 - 1.8e-68 230.3 3.3 2.7e-68 229.7 3.3 1.3 1 0 0 1 1 1 1 ATP synthase subunit D HtrL_YibB PF09612.10 EEA28298.1 - 0.073 12.6 0.4 0.11 12.0 0.4 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) CobA_CobO_BtuR PF02572.15 EEA28298.1 - 0.18 12.0 2.2 0.54 10.5 0.1 2.3 1 1 1 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP HAUS6_N PF14661.6 EEA28298.1 - 0.62 9.6 4.8 1.8 8.1 1.6 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus CAF-1_p150 PF11600.8 EEA28298.1 - 1.1 8.9 12.6 5.7 6.6 0.2 2.2 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal RRM_1 PF00076.22 EEA28299.1 - 1.7e-26 91.8 0.3 2.1e-12 46.7 0.3 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA28299.1 - 8.4e-07 28.6 0.0 4.5e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Stm1_N PF09598.10 EEA28299.1 - 0.01 16.7 0.6 0.025 15.4 0.6 1.7 1 0 0 1 1 1 1 Stm1 Limkain-b1 PF11608.8 EEA28299.1 - 0.022 14.8 0.0 0.066 13.3 0.0 1.8 2 0 0 2 2 2 0 Limkain b1 DUF4523 PF15023.6 EEA28299.1 - 0.13 12.1 0.0 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) PHM7_cyt PF14703.6 EEA28299.1 - 0.23 11.7 1.7 3.5 7.8 0.0 2.7 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 EEA28300.1 - 4.3e-26 90.5 0.1 5.1e-12 45.4 0.1 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA28300.1 - 4.6e-05 23.0 0.0 0.0025 17.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Stm1_N PF09598.10 EEA28300.1 - 0.01 16.7 0.6 0.025 15.4 0.6 1.7 1 0 0 1 1 1 0 Stm1 Limkain-b1 PF11608.8 EEA28300.1 - 0.036 14.1 0.0 0.095 12.8 0.0 1.8 2 0 0 2 2 2 0 Limkain b1 PHM7_cyt PF14703.6 EEA28300.1 - 0.71 10.1 2.8 5 7.3 0.0 2.7 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter TFCD_C PF12612.8 EEA28301.1 - 6.8e-41 140.2 0.2 2.5e-40 138.3 0.2 2.1 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 EEA28301.1 - 2.4e-05 24.2 16.4 0.44 10.9 0.1 7.5 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 EEA28301.1 - 0.00023 21.5 2.5 8.1 6.9 0.1 5.9 5 1 0 5 5 5 2 HEAT repeats IFRD PF05004.13 EEA28301.1 - 0.0011 18.2 5.8 0.017 14.3 0.2 3.1 4 0 0 4 4 4 2 Interferon-related developmental regulator (IFRD) DUF2496 PF10689.9 EEA28301.1 - 0.05 13.4 0.5 0.15 11.9 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2496) Vac14_Fab1_bd PF12755.7 EEA28301.1 - 0.12 12.9 0.1 46 4.7 0.0 4.3 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region Pkinase PF00069.25 EEA28302.1 - 9.4e-61 205.5 0.0 1.7e-60 204.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28302.1 - 1.4e-36 126.1 0.0 2.3e-36 125.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EEA28302.1 - 1.3e-29 102.1 14.5 1.9e-15 56.7 4.1 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EEA28302.1 - 1e-20 73.3 29.8 2.8e-12 46.3 9.7 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EEA28302.1 - 1.6e-13 51.1 1.2 1.6e-13 51.1 1.2 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 EEA28302.1 - 2e-06 28.0 0.0 3.9e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EEA28302.1 - 0.005 16.2 0.0 0.0099 15.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EEA28302.1 - 0.54 9.9 5.1 0.46 10.1 0.1 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Uds1 PF15456.6 EEA28302.1 - 6.7 6.9 7.8 3.4 7.8 1.3 2.6 2 0 0 2 2 2 0 Up-regulated During Septation zf-RING_9 PF13901.6 EEA28302.1 - 7.6 6.5 22.7 5.1 7.0 7.8 2.5 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon FYVE_2 PF02318.16 EEA28302.1 - 7.9 6.7 20.5 6 7.1 5.8 2.7 1 1 1 2 2 2 0 FYVE-type zinc finger MFS_1 PF07690.16 EEA28303.1 - 2.2e-36 125.5 51.3 3.1e-34 118.5 35.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA28303.1 - 6.2e-08 31.6 20.1 1.3e-05 24.0 3.8 2.4 1 1 1 2 2 2 2 MFS/sugar transport protein eIF-1a PF01176.19 EEA28304.1 - 1.2e-17 63.5 0.0 1.6e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 ALG3 PF05208.13 EEA28305.1 - 2.2e-143 478.0 18.4 2.6e-143 477.8 18.4 1.0 1 0 0 1 1 1 1 ALG3 protein COA2 PF17051.5 EEA28306.1 - 0.006 16.6 0.0 0.0082 16.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 DUF3708 PF12501.8 EEA28306.1 - 0.1 12.4 0.1 0.13 12.0 0.1 1.1 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter Metallophos PF00149.28 EEA28307.1 - 1.4e-23 84.4 0.0 1.1e-14 55.5 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos PF00149.28 EEA28308.1 - 9.2e-31 107.9 0.0 5e-22 79.4 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA28308.1 - 0.13 12.8 0.1 0.32 11.5 0.1 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Ank_4 PF13637.6 EEA28309.1 - 2.2e-31 107.8 0.0 3.7e-11 43.3 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA28309.1 - 9.1e-31 106.3 0.1 2.4e-10 40.9 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EEA28309.1 - 1.5e-30 104.3 0.1 4.3e-05 23.8 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EEA28309.1 - 1.6e-28 98.4 0.1 8.8e-12 45.0 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28309.1 - 2.1e-24 82.9 0.0 0.0019 18.5 0.0 6.1 6 0 0 6 6 6 5 Ankyrin repeat Fungal_trans PF04082.18 EEA28310.1 - 1.6e-40 138.8 0.0 3e-40 138.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28310.1 - 1.9e-07 31.1 8.0 4e-07 30.1 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PHD PF00628.29 EEA28310.1 - 0.0039 17.0 3.8 0.01 15.7 3.8 1.7 1 0 0 1 1 1 1 PHD-finger GST_C PF00043.25 EEA28312.1 - 4.3e-09 36.5 0.0 8.6e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA28312.1 - 4.7e-07 30.0 0.0 8.6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EEA28312.1 - 1.6e-06 28.4 0.0 3.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA28312.1 - 4.1e-06 26.9 0.0 8.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EEA28312.1 - 0.015 15.6 0.0 0.055 13.8 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA28312.1 - 0.019 15.0 0.2 0.051 13.6 0.2 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Methyltransf_25 PF13649.6 EEA28314.1 - 1.8e-10 41.4 0.0 3.4e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA28314.1 - 2.2e-08 34.1 0.0 3.1e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA28314.1 - 7.2e-05 22.6 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA28314.1 - 0.00012 22.8 0.0 0.00018 22.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EEA28314.1 - 0.0091 15.5 0.0 0.036 13.6 0.0 1.8 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain SnoaL_2 PF12680.7 EEA28314.1 - 0.017 15.7 0.1 70 4.2 0.0 3.4 3 1 0 3 3 3 0 SnoaL-like domain SnoaL_3 PF13474.6 EEA28314.1 - 0.092 13.0 0.1 1.5 9.1 0.1 2.3 2 0 0 2 2 2 0 SnoaL-like domain Zn_clus PF00172.18 EEA28315.1 - 8.7e-05 22.6 12.0 0.00017 21.7 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Haem_bd PF14376.6 EEA28315.1 - 0.014 15.3 1.0 0.034 14.1 1.0 1.5 1 0 0 1 1 1 0 Haem-binding domain Aminotran_1_2 PF00155.21 EEA28316.1 - 9.4e-39 133.6 0.1 1.2e-38 133.3 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Yopt PF09467.10 EEA28316.1 - 0.057 13.5 0.1 4 7.6 0.0 3.1 3 0 0 3 3 3 0 Hypothetical protein Yopt FERM_M PF00373.18 EEA28316.1 - 0.2 12.1 0.2 0.64 10.4 0.1 1.9 2 1 0 2 2 2 0 FERM central domain Trp_DMAT PF11991.8 EEA28317.1 - 2.9e-85 286.9 0.3 3.7e-85 286.5 0.3 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase p450 PF00067.22 EEA28318.1 - 1.3e-41 142.8 0.3 1.6e-41 142.5 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mating_N PF12731.7 EEA28318.1 - 0.019 15.1 2.1 1.1 9.4 0.1 2.7 2 0 0 2 2 2 0 Mating-type protein beta 1 DHC PF09626.10 EEA28318.1 - 0.097 13.6 0.2 0.81 10.6 0.1 2.2 2 0 0 2 2 2 0 Dihaem cytochrome c MFS_1 PF07690.16 EEA28319.1 - 1.1e-42 146.2 55.6 1e-41 143.1 55.6 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA28319.1 - 8.4e-10 37.7 31.0 8.4e-10 37.7 31.0 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EEA28319.1 - 5.4e-08 32.1 41.2 5.2e-07 28.9 17.2 3.3 3 2 0 3 3 3 2 Sugar (and other) transporter MFS_4 PF06779.14 EEA28319.1 - 0.00021 20.7 10.7 0.00021 20.7 10.7 2.5 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB Peptidase_M19 PF01244.21 EEA28320.1 - 3e-96 322.4 0.1 3.7e-96 322.0 0.1 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Methyltransf_31 PF13847.6 EEA28321.1 - 3.4e-08 33.4 0.0 5.8e-08 32.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA28321.1 - 4.7e-08 33.0 0.0 7.6e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA28321.1 - 1.6e-06 28.7 0.0 2.8e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA28321.1 - 0.0054 17.5 0.0 0.0092 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA28321.1 - 0.011 16.4 0.0 0.018 15.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain HTH_46 PF15977.5 EEA28321.1 - 0.15 12.1 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding p450 PF00067.22 EEA28322.1 - 4.3e-29 101.6 0.0 5.7e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.28 EEA28323.1 - 9e-145 482.5 0.0 1.6e-74 251.0 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EEA28323.1 - 1.7e-62 211.6 0.0 7.3e-33 113.9 0.0 2.8 3 0 0 3 3 3 2 Condensation domain PP-binding PF00550.25 EEA28323.1 - 2.9e-14 53.2 0.1 4.1e-07 30.2 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EEA28323.1 - 6.8e-09 36.6 0.2 0.00097 20.1 0.3 2.6 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain DNA_ligase_A_M PF01068.21 EEA28325.1 - 1.3e-45 155.6 0.0 8e-45 153.0 0.0 2.4 3 0 0 3 3 3 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EEA28325.1 - 1.9e-44 152.0 0.0 6.1e-44 150.4 0.0 1.9 2 0 0 2 2 2 1 DNA ligase N terminus BRCT_2 PF16589.5 EEA28325.1 - 3.3e-21 75.5 0.0 3.8e-16 59.3 0.1 3.3 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 EEA28325.1 - 3e-18 66.2 0.1 5.8e-17 62.1 0.0 2.9 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EEA28325.1 - 1.1e-16 61.6 0.0 2e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 RNA ligase BRCT PF00533.26 EEA28325.1 - 1e-06 29.0 0.0 1.3e-05 25.4 0.0 2.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EEA28325.1 - 0.00016 21.9 0.2 0.029 14.7 0.0 2.5 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EEA28325.1 - 0.001 18.9 0.1 0.03 14.2 0.0 2.4 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain Fungal_trans PF04082.18 EEA28326.1 - 8.2e-13 48.0 2.8 8.2e-13 48.0 2.8 2.2 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28326.1 - 3.5e-05 23.8 11.4 6.9e-05 22.9 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FliG_N PF14842.6 EEA28326.1 - 0.044 14.3 0.0 0.081 13.5 0.0 1.3 1 0 0 1 1 1 0 FliG N-terminal domain EF-hand_4 PF12763.7 EEA28327.1 - 5.6e-06 26.2 0.1 1.1e-05 25.3 0.1 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Macoilin PF09726.9 EEA28327.1 - 2.1 6.8 5.5 2.6 6.5 5.5 1.2 1 0 0 1 1 1 0 Macoilin family Zn_clus PF00172.18 EEA28328.1 - 2.5e-07 30.7 7.5 4.5e-07 29.9 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA28328.1 - 0.0062 15.6 0.3 0.012 14.7 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Spb1_C PF07780.12 EEA28330.1 - 3.4e-87 291.5 22.5 3.4e-87 291.5 22.5 3.1 3 0 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EEA28330.1 - 2.2e-56 190.7 0.0 4.3e-56 189.8 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EEA28330.1 - 1.4e-50 171.3 13.9 1.4e-50 171.3 13.9 4.1 4 0 0 4 4 4 2 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 EEA28330.1 - 0.02 14.7 0.0 0.046 13.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 EEA28331.1 - 4.4e-76 255.0 0.0 6.7e-76 254.4 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 DUF3246 PF11596.8 EEA28331.1 - 0.64 9.4 3.4 1.1 8.6 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) ATG16 PF08614.11 EEA28332.1 - 9.1e-57 192.5 27.8 1e-56 192.4 27.8 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 EEA28332.1 - 2.4e-05 24.1 9.7 3.9e-05 23.5 9.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) Golgin_A5 PF09787.9 EEA28332.1 - 0.004 16.7 17.5 0.0047 16.5 17.5 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 FlaC_arch PF05377.11 EEA28332.1 - 0.097 13.1 4.7 6.7 7.2 0.4 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Snapin_Pallidin PF14712.6 EEA28332.1 - 0.19 12.1 9.3 0.46 10.9 2.3 2.5 1 1 1 2 2 2 0 Snapin/Pallidin UPF0242 PF06785.11 EEA28332.1 - 0.21 11.6 14.9 0.26 11.4 3.4 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HisKA_3 PF07730.13 EEA28332.1 - 0.22 12.1 10.4 0.87 10.2 0.4 2.8 2 0 0 2 2 2 0 Histidine kinase BRE1 PF08647.11 EEA28332.1 - 0.33 11.1 16.3 0.03 14.4 9.8 2.4 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase GAS PF13851.6 EEA28332.1 - 0.35 10.2 14.0 1.1 8.6 3.7 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding IFT57 PF10498.9 EEA28332.1 - 0.37 9.7 12.5 0.035 13.1 7.6 1.6 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 EEA28332.1 - 0.94 9.5 5.3 3.9 7.5 5.2 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) YabA PF06156.13 EEA28332.1 - 2 9.1 12.8 0.32 11.7 2.8 2.7 2 1 1 3 3 3 0 Initiation control protein YabA XhlA PF10779.9 EEA28332.1 - 2.7 8.2 5.6 12 6.2 1.8 2.4 2 0 0 2 2 2 0 Haemolysin XhlA Ndc1_Nup PF09531.10 EEA28332.1 - 4.4 5.9 9.0 5.2 5.6 9.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spc7 PF08317.11 EEA28332.1 - 4.9 5.9 18.2 3.2 6.6 12.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 EEA28332.1 - 7.3 5.8 24.2 1.6e+02 1.5 24.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Occludin_ELL PF07303.13 EEA28332.1 - 9 7.1 7.9 14 6.5 0.3 2.9 2 1 1 3 3 3 0 Occludin homology domain DUF724 PF05266.14 EEA28332.1 - 9.4 6.0 11.4 1.9 8.3 3.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Ras PF00071.22 EEA28333.1 - 2.4e-56 189.8 0.0 2.8e-56 189.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA28333.1 - 3.4e-32 111.2 0.0 4.7e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA28333.1 - 2e-12 46.9 0.0 2.4e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA28333.1 - 9.2e-08 32.2 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EEA28333.1 - 2.7e-06 26.9 0.0 3.3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA28333.1 - 1.6e-05 24.5 0.0 0.0005 19.7 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA28333.1 - 0.00032 20.6 0.2 0.0044 16.9 0.1 2.3 1 1 2 3 3 3 1 RsgA GTPase ATP_bind_1 PF03029.17 EEA28333.1 - 0.0012 18.7 0.2 0.034 13.9 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EEA28333.1 - 0.0024 17.6 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 EEA28333.1 - 0.0042 16.4 0.1 0.062 12.6 0.0 2.1 2 0 0 2 2 2 1 Septin cobW PF02492.19 EEA28333.1 - 0.0048 16.5 0.0 0.021 14.4 0.0 1.8 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EEA28333.1 - 0.0092 16.0 0.0 0.019 15.0 0.0 1.6 2 1 1 3 3 2 1 AAA domain (dynein-related subfamily) SRPRB PF09439.10 EEA28333.1 - 0.0096 15.4 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EEA28333.1 - 0.0096 16.2 0.0 0.022 15.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA28333.1 - 0.014 15.8 0.0 0.019 15.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EEA28333.1 - 0.02 14.6 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EEA28333.1 - 0.027 14.0 0.1 0.046 13.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EEA28333.1 - 0.073 13.0 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 EEA28333.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EEA28333.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 EEA28333.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 EEA28333.1 - 0.15 11.2 0.3 0.3 10.2 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain EamA PF00892.20 EEA28334.1 - 2.1e-13 50.6 40.3 2.5e-07 30.9 5.2 3.1 3 0 0 3 3 3 3 EamA-like transporter family DUF3955 PF13127.6 EEA28334.1 - 6.6e-05 22.6 3.9 6.6e-05 22.6 3.9 3.1 4 0 0 4 4 4 1 Protein of unknown function (DUF3955) UAA PF08449.11 EEA28334.1 - 0.00049 19.4 8.7 0.00049 19.4 8.7 1.8 2 0 0 2 2 2 1 UAA transporter family SLC35F PF06027.12 EEA28334.1 - 0.0023 17.5 18.5 0.027 14.0 11.8 3.0 2 1 0 2 2 2 2 Solute carrier family 35 Neur_chan_memb PF02932.16 EEA28334.1 - 0.096 12.7 1.2 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PH PF00169.29 EEA28335.1 - 1.1e-23 83.8 0.5 2.9e-12 47.0 0.0 2.2 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EEA28335.1 - 4.5e-11 43.1 0.2 0.00053 20.4 0.1 4.2 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EEA28335.1 - 1.5e-08 35.0 0.8 0.00024 21.5 0.1 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain Glyco_transf_15 PF01793.16 EEA28336.1 - 3.7e-96 322.2 7.0 8.4e-96 321.0 7.0 1.5 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase OPT PF03169.15 EEA28337.1 - 1.4e-173 578.9 53.8 1.6e-173 578.7 53.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein p450 PF00067.22 EEA28338.1 - 1.9e-29 102.7 0.0 5.4e-29 101.2 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF1972 PF09314.11 EEA28338.1 - 0.037 13.6 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) Cas9-BH PF16593.5 EEA28338.1 - 0.064 13.0 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 Bridge helix of CRISPR-associated endonuclease Cas9 p450 PF00067.22 EEA28339.1 - 0.059 12.1 0.1 0.6 8.8 0.0 2.3 3 0 0 3 3 3 0 Cytochrome P450 Questin_oxidase PF14027.6 EEA28340.1 - 1.9e-90 303.9 0.1 2.2e-90 303.6 0.1 1.0 1 0 0 1 1 1 1 Questin oxidase-like AMP-binding PF00501.28 EEA28341.1 - 6.8e-52 176.5 0.0 8.8e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Myb_DNA-binding PF00249.31 EEA28341.1 - 0.065 13.4 0.0 13 6.1 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain NAD_binding_10 PF13460.6 EEA28342.1 - 7.5e-15 55.3 0.0 9.1e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA28342.1 - 4.8e-08 32.8 0.0 9.3e-08 31.9 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 EEA28342.1 - 0.014 15.8 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EEA28342.1 - 0.015 14.5 0.0 0.028 13.6 0.0 1.5 1 0 0 1 1 1 0 Male sterility protein 3Beta_HSD PF01073.19 EEA28342.1 - 0.017 14.1 0.0 0.02 13.9 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.17 EEA28342.1 - 0.019 15.5 0.0 0.034 14.7 0.0 1.5 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 EEA28342.1 - 0.043 12.9 0.0 0.056 12.6 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein KR PF08659.10 EEA28342.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 KR domain adh_short PF00106.25 EEA28343.1 - 1.1e-21 77.1 0.0 4.3e-20 72.0 0.1 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28343.1 - 7.2e-12 45.4 0.1 2.7e-11 43.5 0.2 1.8 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA28343.1 - 2.4e-07 30.9 0.1 3.6e-07 30.3 0.1 1.3 1 0 0 1 1 1 1 KR domain FAD_binding_3 PF01494.19 EEA28344.1 - 2.9e-12 46.5 0.1 1.1e-11 44.7 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA28344.1 - 1.4e-06 28.1 0.1 0.034 13.7 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA28344.1 - 6.7e-05 22.3 0.0 0.14 11.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA28344.1 - 0.00031 20.0 0.1 0.0013 17.9 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EEA28344.1 - 0.026 13.2 0.2 0.21 10.3 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.7 EEA28344.1 - 0.066 12.6 0.1 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase AflR PF08493.10 EEA28345.1 - 1.1e-12 48.0 14.3 2.7e-12 46.8 14.3 1.6 1 1 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EEA28345.1 - 2.3e-08 34.0 12.1 4.7e-08 33.0 12.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clusterin PF01093.17 EEA28345.1 - 0.04 13.0 0.5 0.058 12.4 0.5 1.2 1 0 0 1 1 1 0 Clusterin Opy2 PF09463.10 EEA28345.1 - 1.2 9.5 12.7 0.4 11.0 2.5 3.4 3 0 0 3 3 3 0 Opy2 protein Anti-TRAP PF15777.5 EEA28345.1 - 1.4 9.0 0.0 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Beta-lactamase PF00144.24 EEA28346.1 - 5.2e-39 134.4 0.0 7.6e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase adh_short PF00106.25 EEA28348.1 - 7.4e-35 120.2 2.4 8.8e-35 119.9 2.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28348.1 - 8e-24 84.5 2.4 2.2e-23 83.0 2.4 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA28348.1 - 1.1e-13 51.5 1.9 1.5e-13 51.0 1.9 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA28348.1 - 3.2e-11 42.9 0.4 4.1e-11 42.6 0.4 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA28348.1 - 4.3e-09 36.2 0.7 8.7e-09 35.2 0.7 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA28348.1 - 0.00035 20.1 0.9 0.0057 16.1 0.9 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase ThiF PF00899.21 EEA28348.1 - 0.035 13.4 1.3 1.1 8.6 0.2 2.2 2 0 0 2 2 2 0 ThiF family Eno-Rase_NADH_b PF12242.8 EEA28348.1 - 0.041 13.7 0.2 0.11 12.2 0.2 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Shikimate_DH PF01488.20 EEA28348.1 - 0.16 12.0 0.2 0.98 9.5 0.2 2.0 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Lactamase_B PF00753.27 EEA28349.1 - 4.9e-16 59.3 4.2 3.8e-14 53.2 4.2 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA28349.1 - 0.00014 21.4 1.3 0.00029 20.4 1.3 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain ketoacyl-synt PF00109.26 EEA28350.1 - 3.8e-75 252.7 0.0 7.4e-75 251.8 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EEA28350.1 - 1.3e-50 172.4 0.1 9.4e-49 166.3 0.0 3.0 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EEA28350.1 - 4.9e-43 147.8 0.0 1.5e-42 146.3 0.0 1.8 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA28350.1 - 2.6e-34 117.8 0.4 6.4e-34 116.5 0.4 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EEA28350.1 - 1.7e-10 41.1 0.1 6.5e-10 39.2 0.1 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EEA28350.1 - 1.2e-08 35.4 0.0 3.6e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 EEA28350.1 - 5.5e-08 32.4 0.0 9.9e-08 31.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EEA28350.1 - 2.8e-05 23.6 0.2 8.1e-05 22.1 0.2 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain Scytalone_dh PF02982.14 EEA28351.1 - 1.4e-68 229.7 0.5 1.6e-68 229.5 0.5 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EEA28351.1 - 8.8e-08 32.3 0.4 1e-07 32.1 0.4 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 EEA28351.1 - 0.3 11.4 1.8 2.2 8.5 0.2 2.2 1 1 1 2 2 2 0 SnoaL-like domain adh_short_C2 PF13561.6 EEA28352.1 - 8.8e-57 192.4 2.5 1.2e-56 191.9 2.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA28352.1 - 2.3e-48 164.2 1.0 2.9e-48 163.9 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA28352.1 - 1.6e-11 44.5 0.7 2.1e-11 44.1 0.7 1.1 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 EEA28352.1 - 0.0034 16.8 0.9 0.047 13.1 0.2 2.2 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 EEA28352.1 - 0.0043 16.6 0.7 0.035 13.6 0.7 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 EEA28352.1 - 0.02 14.9 0.3 0.89 9.5 0.3 2.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase DUF1776 PF08643.10 EEA28352.1 - 0.073 12.4 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Frtz PF11768.8 EEA28353.1 - 0.0032 15.9 0.0 0.0049 15.3 0.0 1.2 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz HTH_7 PF02796.15 EEA28353.1 - 0.14 12.3 0.0 0.49 10.5 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase MFS_1 PF07690.16 EEA28354.1 - 6.5e-44 150.3 52.9 1.3e-43 149.3 49.9 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA28354.1 - 1e-09 37.4 14.8 2e-09 36.5 14.8 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) EthD PF07110.11 EEA28355.1 - 5.3e-18 66.0 0.4 7e-18 65.6 0.4 1.2 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EEA28355.1 - 0.00014 22.3 0.1 0.00021 21.7 0.1 1.3 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase GxGYxYP_N PF16216.5 EEA28355.1 - 0.0087 16.3 0.0 0.01 16.1 0.0 1.1 1 0 0 1 1 1 1 GxGYxY sequence motif in domain of unknown function N-terminal DUF1772 PF08592.11 EEA28356.1 - 8e-29 100.7 2.4 1e-28 100.3 2.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) MFS_1 PF07690.16 EEA28356.1 - 0.0009 18.3 3.4 0.0012 17.9 3.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PalH PF08733.10 EEA28356.1 - 0.034 13.2 0.1 0.12 11.4 0.0 1.6 1 1 1 2 2 2 0 PalH/RIM21 Transferase PF02458.15 EEA28357.1 - 6.6e-22 77.8 0.0 4.1e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 Transferase family adh_short PF00106.25 EEA28358.1 - 5.4e-13 48.8 0.0 7.8e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28358.1 - 1.2e-10 41.3 0.0 1.6e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.17 EEA28358.1 - 0.00091 18.4 0.0 0.0012 18.0 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EEA28358.1 - 0.011 15.7 0.0 0.05 13.5 0.0 1.9 1 1 0 1 1 1 0 KR domain Epimerase PF01370.21 EEA28358.1 - 0.014 14.8 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Hemerythrin PF01814.23 EEA28359.1 - 1.6e-06 28.7 0.0 2.5e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Chloroplast_duf PF14476.6 EEA28359.1 - 0.2 10.6 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 Petal formation-expressed SnoaL_2 PF12680.7 EEA28360.1 - 0.023 15.3 0.0 0.037 14.7 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain RVT_2 PF07727.14 EEA28361.1 - 1.8e-35 122.8 0.1 2.9e-35 122.1 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA28361.1 - 1.4e-07 31.7 0.0 4.4e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EEA28361.1 - 2e-07 30.7 0.0 4.9e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_1 PF00078.27 EEA28361.1 - 0.025 14.1 0.0 0.059 12.9 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) PixA PF12306.8 EEA28361.1 - 0.09 13.0 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 Inclusion body protein p450 PF00067.22 EEA28362.1 - 6.6e-50 170.2 0.0 9.4e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1501 PF07394.12 EEA28363.1 - 0.13 11.3 1.7 0.21 10.6 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PIEZO PF15917.5 EEA28363.1 - 0.67 9.4 5.7 1.1 8.7 5.7 1.3 1 0 0 1 1 1 0 Piezo DUF4407 PF14362.6 EEA28363.1 - 1.1 8.6 4.3 1.5 8.1 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fungal_trans PF04082.18 EEA28364.1 - 1.4e-34 119.4 2.7 2.1e-34 118.8 2.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA28364.1 - 2.3e-05 24.6 18.8 0.0029 18.0 2.9 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA28364.1 - 0.00072 20.2 10.6 0.21 12.5 1.6 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EEA28364.1 - 0.0066 16.7 0.8 0.018 15.3 0.8 1.7 1 0 0 1 1 1 1 C2H2-type zinc ribbon Oxidored_FMN PF00724.20 EEA28365.1 - 1.1e-88 297.8 0.0 1.3e-88 297.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family FAD_binding_3 PF01494.19 EEA28366.1 - 2.1e-73 247.6 0.0 2.8e-73 247.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EEA28366.1 - 1.1e-25 90.6 0.0 2e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EEA28366.1 - 0.00025 20.4 0.1 0.0012 18.2 0.0 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA28366.1 - 0.0003 19.6 0.1 0.00046 19.0 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EEA28366.1 - 0.00031 21.3 0.0 0.00067 20.2 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA28366.1 - 0.00086 19.5 0.0 0.0022 18.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EEA28366.1 - 0.0011 18.7 0.0 0.0026 17.4 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA28366.1 - 0.0053 16.0 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EEA28366.1 - 0.011 14.8 0.1 0.017 14.2 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EEA28366.1 - 0.024 13.9 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EEA28366.1 - 0.028 13.7 0.0 0.06 12.6 0.0 1.5 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EEA28366.1 - 0.033 13.3 0.1 0.069 12.2 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain 2-Hacid_dh_C PF02826.19 EEA28366.1 - 0.05 13.0 0.0 0.16 11.4 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA28366.1 - 0.098 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EEA28366.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding IlvN PF07991.12 EEA28366.1 - 0.12 12.0 0.0 0.31 10.6 0.0 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain GIDA PF01134.22 EEA28366.1 - 0.26 10.3 0.0 0.4 9.7 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A adh_short_C2 PF13561.6 EEA28367.1 - 1.8e-58 197.8 0.2 2.1e-58 197.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA28367.1 - 2e-41 141.6 0.1 2.7e-41 141.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA28367.1 - 7.4e-09 35.8 0.1 1.4e-08 34.8 0.1 1.6 1 1 0 1 1 1 1 KR domain FAD_binding_3 PF01494.19 EEA28368.1 - 4.5e-11 42.6 0.3 2.9e-07 30.0 0.0 2.5 2 1 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 EEA28368.1 - 5.6e-05 22.0 2.5 0.00026 19.8 2.5 1.8 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EEA28368.1 - 5.9e-05 22.5 0.4 0.0038 16.5 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA28368.1 - 8.3e-05 21.8 6.1 0.00015 21.0 6.1 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA28368.1 - 0.00031 20.4 4.9 0.46 10.0 5.7 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EEA28368.1 - 0.00051 19.0 2.5 0.022 13.7 0.4 2.1 1 1 1 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.12 EEA28368.1 - 0.0031 16.6 1.0 0.0083 15.2 1.0 1.6 1 1 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EEA28368.1 - 0.0033 17.6 3.7 0.0086 16.3 2.8 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EEA28368.1 - 0.0044 17.5 0.3 0.5 11.0 0.6 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA28368.1 - 0.01 15.1 2.0 0.025 13.9 1.3 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Tfb2_C PF18307.1 EEA28368.1 - 0.014 15.8 0.1 0.15 12.5 0.0 2.3 2 0 0 2 2 2 0 Transcription factor Tfb2 (p52) C-terminal domain 3HCDH_N PF02737.18 EEA28368.1 - 0.016 15.1 1.0 0.029 14.2 1.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EEA28368.1 - 0.034 13.5 4.6 0.029 13.7 3.4 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 EEA28368.1 - 0.055 12.6 5.3 0.094 11.8 5.3 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A SE PF08491.10 EEA28368.1 - 0.068 12.2 0.0 0.36 9.8 0.0 1.9 2 0 0 2 2 2 0 Squalene epoxidase AlaDh_PNT_C PF01262.21 EEA28368.1 - 0.19 11.0 0.3 0.38 10.0 0.3 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Polysacc_deac_1 PF01522.21 EEA28369.1 - 3.1e-19 69.1 0.0 5.5e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EEA28369.1 - 0.00013 21.7 0.0 0.00023 20.9 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 EEA28369.1 - 0.065 11.6 0.0 0.088 11.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) Amidase PF01425.21 EEA28370.1 - 3.8e-103 345.8 0.0 5e-103 345.5 0.0 1.1 1 0 0 1 1 1 1 Amidase His_Phos_1 PF00300.22 EEA28371.1 - 7.2e-15 55.2 0.0 8.9e-08 32.1 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF1248 PF06852.12 EEA28371.1 - 0.097 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1248) HECT PF00632.25 EEA28372.1 - 1.4e-67 228.4 0.0 3.2e-67 227.2 0.0 1.6 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EEA28372.1 - 2.2e-21 75.9 1.8 5.3e-21 74.6 1.8 1.7 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Fungal_trans PF04082.18 EEA28373.1 - 4.4e-08 32.5 0.2 7.7e-08 31.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28373.1 - 4.9e-06 26.6 7.4 8.1e-06 25.9 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.12 EEA28374.1 - 1.4e-08 34.6 0.1 2.2e-07 30.7 0.0 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA28374.1 - 3e-08 33.7 0.0 7.9e-08 32.3 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA28374.1 - 2.2e-05 25.5 0.0 3.6e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glyco_tran_WecB PF03808.13 EEA28374.1 - 0.059 13.3 0.0 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family ADH_N_2 PF16884.5 EEA28374.1 - 0.1 12.5 0.1 0.57 10.1 0.0 2.0 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase zf-C2H2_2 PF12756.7 EEA28375.1 - 7.2e-38 129.0 8.9 3.5e-30 104.3 3.3 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EEA28375.1 - 9.7e-08 32.2 4.6 9.7e-08 32.2 4.6 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA28375.1 - 1.6e-06 28.2 13.1 2.2e-06 27.8 5.2 3.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EEA28375.1 - 0.0048 17.3 13.3 0.39 11.3 0.2 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA28375.1 - 0.0086 16.8 11.7 0.82 10.7 0.4 4.5 4 0 0 4 4 4 2 C2H2-type zinc finger MRP-S26 PF14943.6 EEA28375.1 - 8.4 6.3 12.2 13 5.7 0.3 2.3 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 DUF21 PF01595.20 EEA28376.1 - 6.6e-33 113.9 0.2 1.1e-32 113.2 0.2 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EEA28376.1 - 2e-07 31.3 0.8 0.03 14.8 0.0 2.7 2 0 0 2 2 2 2 CBS domain Transket_pyr PF02779.24 EEA28377.1 - 1.3e-41 142.3 0.1 2.3e-41 141.4 0.0 1.4 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EEA28377.1 - 4.1e-31 107.5 0.0 8.2e-31 106.5 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EEA28377.1 - 0.04 14.2 0.0 0.073 13.4 0.0 1.4 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Cnn_1N PF07989.11 EEA28378.1 - 2.3 8.4 24.7 0.59 10.3 0.7 4.6 4 1 0 4 4 4 0 Centrosomin N-terminal motif 1 DUF2347 PF09804.9 EEA28378.1 - 3.9 7.0 8.9 2.3 7.7 2.7 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) Lebercilin PF15619.6 EEA28378.1 - 4.2 7.0 49.1 2.6 7.7 21.1 2.6 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF5320 PF17253.2 EEA28378.1 - 7.8 7.6 11.7 9.3 7.4 0.2 4.0 2 1 2 4 4 4 0 Family of unknown function (DUF5320) DUF1989 PF09347.10 EEA28379.1 - 8.7e-65 217.4 0.0 1.1e-64 217.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) KCH PF16944.5 EEA28380.1 - 3.2e-103 344.9 4.5 3.8e-103 344.6 4.5 1.1 1 0 0 1 1 1 1 Fungal potassium channel HemY_N PF07219.13 EEA28380.1 - 0.54 10.5 2.8 1.9 8.7 0.4 2.2 2 0 0 2 2 2 0 HemY protein N-terminus Glyoxalase PF00903.25 EEA28381.1 - 1e-19 71.0 0.1 4.7e-16 59.2 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EEA28381.1 - 3.6e-11 43.3 0.0 3.2e-05 24.2 0.0 2.5 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 EEA28381.1 - 4.2e-06 27.0 0.0 0.0088 16.2 0.0 2.3 2 0 0 2 2 2 2 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_3 PF13468.6 EEA28381.1 - 0.011 15.8 0.0 2.6 8.1 0.0 2.7 2 1 0 2 2 2 0 Glyoxalase-like domain HgmA PF04209.13 EEA28382.1 - 5.4e-206 684.3 0.2 6.2e-206 684.1 0.2 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase TPR_17 PF13431.6 EEA28384.1 - 0.052 13.9 0.2 0.8 10.2 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat FeoB_Cyto PF17910.1 EEA28384.1 - 0.063 13.8 0.1 0.21 12.2 0.1 2.0 1 1 0 1 1 1 0 FeoB cytosolic helical domain FAA_hydrolase PF01557.18 EEA28385.1 - 8.7e-56 189.0 0.0 1.2e-55 188.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EEA28385.1 - 5e-29 100.6 0.0 8e-29 100.0 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal GST_N_2 PF13409.6 EEA28386.1 - 1.7e-10 41.0 0.1 6.2e-10 39.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA28386.1 - 9.2e-09 35.5 0.0 1.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA28386.1 - 1.2e-08 35.0 0.0 2.8e-08 33.9 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA28386.1 - 3.4e-06 27.2 0.0 9e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA28386.1 - 6e-06 26.6 0.1 1.2e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA28386.1 - 0.0018 18.3 0.1 0.0043 17.0 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EEA28387.1 - 1.7e-10 41.0 0.1 6.2e-10 39.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EEA28387.1 - 9.2e-09 35.5 0.0 1.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EEA28387.1 - 1.2e-08 35.0 0.0 2.8e-08 33.9 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA28387.1 - 3.4e-06 27.2 0.0 9e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA28387.1 - 6e-06 26.6 0.1 1.2e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA28387.1 - 0.0018 18.3 0.1 0.0043 17.0 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glyco_hydro_92 PF07971.12 EEA28388.1 - 3.4e-147 491.1 4.7 4e-147 490.9 4.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EEA28388.1 - 5.4e-66 222.9 0.3 1e-65 222.0 0.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Gln-synt_N PF03951.19 EEA28388.1 - 0.11 12.3 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Glutamine synthetase, beta-Grasp domain Zn_clus PF00172.18 EEA28389.1 - 0.0001 22.4 13.0 0.00017 21.7 13.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF747 PF05346.11 EEA28390.1 - 3.2e-119 398.1 9.9 4.3e-119 397.7 9.9 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family Methyltransf_25 PF13649.6 EEA28391.1 - 2.8e-08 34.4 0.0 7.6e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA28391.1 - 5.7e-07 30.2 0.0 1.4e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA28391.1 - 7.3e-06 25.9 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA28391.1 - 6.8e-05 23.4 0.0 0.00016 22.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EEA28391.1 - 0.046 12.9 0.0 0.094 11.9 0.0 1.6 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Peptidase_M20 PF01546.28 EEA28392.1 - 1.3e-21 77.3 0.0 3.7e-21 75.8 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EEA28392.1 - 5.1e-10 39.8 7.3 0.0029 18.4 0.0 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat M20_dimer PF07687.14 EEA28392.1 - 5.8e-07 29.4 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 EEA28392.1 - 0.0045 17.3 0.1 4.6 7.6 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Sugar_tr PF00083.24 EEA28393.1 - 6.2e-85 285.7 29.8 7.2e-85 285.5 29.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA28393.1 - 8.9e-23 80.8 38.5 9.3e-14 51.1 18.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily KorB_C PF06613.11 EEA28393.1 - 0.21 11.6 0.1 12 5.9 0.0 2.4 1 1 1 2 2 2 0 KorB C-terminal beta-barrel domain Lipase_GDSL_2 PF13472.6 EEA28395.1 - 4e-14 53.4 0.0 4.4e-14 53.3 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EEA28395.1 - 3.4e-08 33.7 0.0 5.3e-07 29.8 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DLH PF01738.18 EEA28395.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family MFS_1 PF07690.16 EEA28396.1 - 8.2e-42 143.4 45.7 8.9e-42 143.3 43.8 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA28396.1 - 4.6e-13 48.4 24.8 6.6e-13 48.0 24.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EEA28396.1 - 0.32 9.2 17.3 0.0097 14.2 4.0 2.7 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TraQ PF09679.10 EEA28397.1 - 0.06 13.3 0.7 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) DUF349 PF03993.12 EEA28397.1 - 2 8.8 6.8 1.2 9.5 2.3 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Abhydrolase_3 PF07859.13 EEA28398.1 - 8e-44 150.0 0.0 1.1e-43 149.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA28398.1 - 2.8e-12 46.3 0.6 1.1e-11 44.4 0.0 2.0 2 1 0 2 2 2 1 Carboxylesterase family Abhydrolase_6 PF12697.7 EEA28398.1 - 0.0032 18.1 0.1 0.0048 17.5 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family p450 PF00067.22 EEA28399.1 - 2.4e-70 237.6 0.0 1.7e-69 234.8 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 Oxidored_FMN PF00724.20 EEA28400.1 - 2.6e-61 207.8 0.0 3.1e-61 207.5 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EEA28400.1 - 0.056 12.5 0.0 1.9 7.5 0.0 2.1 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Pyr_redox_2 PF07992.14 EEA28401.1 - 8.4e-06 25.2 0.2 0.027 13.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA28401.1 - 7.3e-05 22.5 1.4 0.16 11.5 0.4 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EEA28401.1 - 0.00024 20.5 0.0 0.00044 19.6 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EEA28401.1 - 0.0035 16.7 0.1 0.7 9.1 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EEA28401.1 - 0.0058 16.8 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EEA28401.1 - 0.0075 15.5 1.3 0.027 13.7 1.3 1.8 1 1 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EEA28401.1 - 0.0083 15.2 0.0 0.017 14.2 0.0 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EEA28401.1 - 0.03 13.7 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EEA28401.1 - 0.034 14.7 0.0 0.38 11.3 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA28401.1 - 0.16 11.0 0.1 2.7 7.0 0.1 2.0 1 1 1 2 2 2 0 FAD binding domain p450 PF00067.22 EEA28402.1 - 5.2e-67 226.6 0.0 7e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 zf-CHY PF05495.12 EEA28403.1 - 7.7e-12 45.5 8.0 7.7e-12 45.5 8.0 3.6 3 1 0 3 3 3 1 CHY zinc finger FdhE PF04216.12 EEA28403.1 - 1.1 9.1 4.9 0.13 12.1 0.3 1.8 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation DUF3295 PF11702.8 EEA28404.1 - 3.6e-178 594.0 28.2 4.2e-178 593.7 28.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 EEA28404.1 - 1.7e-11 43.8 2.1 3.2e-11 42.8 2.1 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Suv3_C_1 PF18147.1 EEA28404.1 - 0.033 14.1 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 Suv3 C-terminal domain 1 Abhydrolase_6 PF12697.7 EEA28405.1 - 8.5e-06 26.5 0.3 1.2e-05 26.1 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cpn60_TCP1 PF00118.24 EEA28406.1 - 1.4e-157 525.2 4.7 1.6e-157 525.0 4.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Chromo_shadow PF01393.19 EEA28407.1 - 4e-15 55.6 0.6 2.4e-12 46.8 0.2 2.3 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 EEA28407.1 - 2.6e-08 33.7 0.1 5.7e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo PF00385.24 EEA28408.1 - 2.4e-08 33.7 0.1 5.4e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 EEA28408.1 - 1.7e-07 31.2 0.4 0.00012 22.1 0.1 2.3 2 0 0 2 2 2 2 Chromo shadow domain Rap1_C PF11626.8 EEA28409.1 - 5.6e-24 84.0 0.5 3.5e-23 81.5 0.0 2.5 2 1 1 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 EEA28409.1 - 1.9e-21 76.0 2.6 4.3e-21 74.9 0.9 2.4 3 0 0 3 3 3 1 Rap1 Myb domain Rap1-DNA-bind PF09197.10 EEA28409.1 - 3.5e-06 27.6 0.2 1.2e-05 25.8 0.1 1.9 1 1 1 2 2 2 1 Rap1, DNA-binding DUF4376 PF14301.6 EEA28409.1 - 0.081 13.3 0.4 0.26 11.7 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4376) Atx10homo_assoc PF09759.9 EEA28411.1 - 9.1e-32 109.0 0.3 9.1e-32 109.0 0.3 1.9 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain zf-RING_2 PF13639.6 EEA28412.1 - 1.3e-08 35.0 2.3 2e-08 34.4 2.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EEA28412.1 - 8e-06 26.0 2.8 0.00013 22.2 2.8 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EEA28412.1 - 0.00099 19.1 6.6 0.0017 18.3 6.6 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EEA28412.1 - 0.002 18.2 0.5 0.003 17.6 0.5 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EEA28412.1 - 0.019 14.8 5.5 0.13 12.2 4.7 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA28412.1 - 0.036 13.8 1.1 0.065 13.0 1.1 1.4 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EEA28412.1 - 0.099 12.5 1.5 1.1 9.2 1.4 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA28412.1 - 0.21 11.5 2.6 3.5 7.6 0.3 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Putative_PNPOx PF01243.20 EEA28413.1 - 6.4e-07 29.5 0.0 0.00015 21.9 0.0 2.7 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EEA28413.1 - 0.0019 18.5 0.0 0.018 15.4 0.0 2.4 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain MARVEL PF01284.23 EEA28414.1 - 0.00028 20.9 20.6 0.00042 20.4 20.6 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF2070 PF09843.9 EEA28414.1 - 3 6.0 13.1 4 5.6 13.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) NTP_transferase PF00483.23 EEA28415.1 - 8.4e-32 110.7 0.0 1.2e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EEA28415.1 - 2.1e-08 33.6 7.5 2.9e-05 23.6 0.0 3.7 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EEA28415.1 - 2.3e-07 31.3 0.0 3.3e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EEA28415.1 - 0.0094 15.7 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Fucokinase PF07959.12 EEA28415.1 - 0.023 13.7 0.1 4 6.3 0.0 2.1 2 0 0 2 2 2 0 L-fucokinase Dynamin_N PF00350.23 EEA28416.1 - 3e-22 79.5 0.0 7e-22 78.3 0.0 1.7 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EEA28416.1 - 5.6e-21 75.0 0.0 1.7e-20 73.4 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region GED PF02212.18 EEA28416.1 - 0.0062 16.7 2.2 0.0092 16.1 0.1 2.3 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EEA28416.1 - 0.0078 16.3 0.0 0.068 13.3 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EEA28416.1 - 0.011 15.9 0.0 0.31 11.3 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 EEA28416.1 - 0.17 11.5 0.7 3.3 7.3 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain tRNA-synt_2 PF00152.20 EEA28417.1 - 1e-77 261.3 0.6 1.4e-77 260.9 0.6 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA28417.1 - 2.7e-11 43.3 0.0 6.3e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EEA28417.1 - 4e-06 26.5 0.1 0.064 12.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) COX15-CtaA PF02628.15 EEA28418.1 - 1.2e-115 386.0 3.5 1.5e-115 385.7 3.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein PQ-loop PF04193.14 EEA28418.1 - 0.35 10.7 2.1 21 5.0 0.1 2.8 2 0 0 2 2 2 0 PQ loop repeat zf-C3HC PF07967.13 EEA28419.1 - 1.3e-39 135.3 0.8 8.3e-36 123.0 0.5 2.4 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 EEA28419.1 - 8.5e-28 96.4 0.2 6e-27 93.6 0.0 2.3 2 0 0 2 2 2 1 Rsm1-like Pox_MCEL PF03291.16 EEA28420.1 - 4.8e-67 226.4 0.0 3.8e-64 216.9 0.0 3.2 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.12 EEA28420.1 - 8.6e-11 42.5 0.5 2.8e-10 40.8 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA28420.1 - 6.9e-10 39.5 0.0 0.00066 20.3 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EEA28420.1 - 1.5e-06 28.7 0.0 0.023 15.4 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EEA28420.1 - 4.8e-06 26.5 0.0 0.0066 16.2 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EEA28420.1 - 0.00064 19.0 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 EEA28420.1 - 0.00065 19.6 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EEA28420.1 - 0.019 14.4 0.1 0.13 11.7 0.0 2.3 3 0 0 3 3 3 0 Putative methyltransferase zf-Nse PF11789.8 EEA28421.1 - 1.8e-20 72.5 0.1 4.3e-20 71.3 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EEA28421.1 - 0.0018 18.3 0.0 0.013 15.5 0.0 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-MIZ PF02891.20 EEA28421.1 - 0.045 13.5 2.6 0.075 12.8 0.1 2.1 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 EEA28421.1 - 0.045 13.6 0.0 0.045 13.6 0.0 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 EEA28421.1 - 0.049 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 U-box domain Mito_carr PF00153.27 EEA28422.1 - 6.1e-53 176.7 4.0 3.8e-18 65.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tir_receptor_N PF07490.11 EEA28422.1 - 0.12 12.2 0.5 0.25 11.1 0.5 1.5 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus Mito_carr PF00153.27 EEA28423.1 - 6.1e-53 176.7 4.0 3.8e-18 65.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tir_receptor_N PF07490.11 EEA28423.1 - 0.12 12.2 0.5 0.25 11.1 0.5 1.5 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus PEPCK_ATP PF01293.20 EEA28424.1 - 2.8e-218 725.3 0.0 3.4e-218 725.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 EEA28424.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EEA28424.1 - 0.14 12.3 0.1 0.4 10.8 0.1 1.8 1 0 0 1 1 1 0 AAA domain Asparaginase_2 PF01112.18 EEA28425.1 - 2.2e-46 158.3 12.1 7.2e-31 107.4 1.0 2.1 2 0 0 2 2 2 2 Asparaginase DGF-1_4 PF11024.8 EEA28425.1 - 1.4 9.7 9.1 0.98 10.3 2.3 2.6 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Actin PF00022.19 EEA28426.1 - 6.5e-88 295.1 0.0 2.2e-85 286.7 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EEA28426.1 - 0.038 12.8 0.0 1.1 8.0 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein tRNA_U5-meth_tr PF05958.11 EEA28427.1 - 2.8e-12 46.3 0.0 1.5e-05 24.2 0.0 2.8 3 0 0 3 3 3 2 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 EEA28427.1 - 0.00026 20.6 0.0 0.00047 19.8 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 EEA28427.1 - 0.0014 18.5 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA28427.1 - 0.0022 18.7 0.0 0.0053 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA28427.1 - 0.0056 16.1 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EEA28427.1 - 0.046 13.3 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ribosomal_S5_C PF03719.15 EEA28428.1 - 1.5e-24 85.2 0.0 2.7e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 EEA28428.1 - 1.7e-17 63.1 0.4 7e-17 61.2 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain DASH_Dad3 PF08656.10 EEA28429.1 - 1.1e-26 92.7 1.9 1.3e-26 92.4 1.9 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 Pkinase PF00069.25 EEA28430.1 - 2.6e-74 249.9 0.0 3.5e-74 249.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28430.1 - 6.8e-30 104.2 0.0 1.7e-21 76.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA28430.1 - 9.6e-07 28.4 0.1 0.46 9.7 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 EEA28430.1 - 0.016 14.0 0.2 0.052 12.3 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 EEA28430.1 - 0.043 13.2 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA28430.1 - 0.18 11.7 0.0 2.9 7.8 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA28430.1 - 1.1 8.1 0.0 1.1 8.1 0.0 2.4 3 0 0 3 3 3 0 Haspin like kinase domain ASD2 PF08687.11 EEA28431.1 - 0.017 14.7 0.4 0.017 14.7 0.4 1.8 3 0 0 3 3 3 0 Apx/Shroom domain ASD2 His_Phos_2 PF00328.22 EEA28432.1 - 3.4e-09 36.5 0.1 5.7e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) adh_short PF00106.25 EEA28434.1 - 2.1e-23 82.8 0.1 6.5e-19 68.2 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28434.1 - 1.3e-12 47.8 0.0 2.6e-09 37.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA28434.1 - 4.2e-09 36.6 0.1 6.9e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 KR domain Pectinesterase PF01095.19 EEA28435.1 - 8e-28 97.0 13.3 9.8e-25 86.9 13.3 2.9 1 1 0 1 1 1 1 Pectinesterase Phosphonate-bd PF12974.7 EEA28435.1 - 0.082 12.5 0.5 0.25 10.9 0.5 1.7 2 0 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein CN_hydrolase PF00795.22 EEA28436.1 - 1.1e-46 159.3 0.0 1.4e-46 159.0 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase TRF PF08558.10 EEA28438.1 - 8.4e-85 284.2 2.8 1.2e-84 283.7 2.8 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EEA28438.1 - 0.0005 20.2 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Packaging_FI PF14000.6 EEA28438.1 - 0.13 12.8 2.0 0.2 12.1 0.3 2.1 2 0 0 2 2 2 0 DNA packaging protein FI Ribophorin_I PF04597.14 EEA28438.1 - 0.36 10.0 9.4 0.6 9.2 9.4 1.3 1 0 0 1 1 1 0 Ribophorin I TFIID_30kDa PF03540.13 EEA28439.1 - 1e-22 79.8 0.1 1.7e-22 79.1 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit DUF4620 PF15399.6 EEA28439.1 - 2.1 8.7 8.1 0.36 11.2 4.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4620) TT_ORF2 PF02957.15 EEA28439.1 - 6.5 7.7 7.8 1.3 9.9 1.7 2.5 2 0 0 2 2 2 0 TT viral ORF2 Ribosomal_S19 PF00203.21 EEA28440.1 - 2.1e-24 85.2 0.0 2.7e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_S19 PF00203.21 EEA28441.1 - 2.4e-21 75.4 0.0 2.9e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 DDE_1 PF03184.19 EEA28442.1 - 1.1e-31 109.8 0.0 2.5e-31 108.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EEA28442.1 - 2.1e-13 50.1 0.1 5e-13 48.9 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EEA28442.1 - 3.8e-05 23.3 0.1 0.00013 21.6 0.1 2.0 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.6 EEA28442.1 - 0.0042 17.2 0.1 0.017 15.2 0.1 2.1 1 0 0 1 1 1 1 Helix-turn-helix domain zf-CCHC_4 PF14392.6 EEA28442.1 - 0.011 15.4 0.3 0.024 14.4 0.3 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 EEA28442.1 - 0.026 14.4 1.7 0.057 13.3 1.7 1.6 1 0 0 1 1 1 0 Zinc knuckle HTH_29 PF13551.6 EEA28442.1 - 0.063 13.3 0.3 2.4 8.2 0.1 3.1 3 0 0 3 3 3 0 Winged helix-turn helix HTH_23 PF13384.6 EEA28442.1 - 0.14 12.0 0.6 1.9 8.4 0.1 2.7 2 0 0 2 2 2 0 Homeodomain-like domain DUF2089 PF09862.9 EEA28442.1 - 0.28 11.2 3.1 0.26 11.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) IPK PF03770.16 EEA28443.1 - 1e-60 205.0 0.0 1.4e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase Arb1 PF09692.10 EEA28444.1 - 3.7e-125 418.2 0.0 5e-125 417.8 0.0 1.1 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 AcylCoA_dehyd_C PF12186.8 EEA28444.1 - 0.14 12.3 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal Alph_Pro_TM PF09608.10 EEA28444.1 - 0.2 11.5 0.1 0.31 10.8 0.1 1.3 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) ADH_zinc_N PF00107.26 EEA28445.1 - 1e-25 90.2 0.1 1.9e-25 89.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EEA28445.1 - 8e-22 78.7 0.0 1.8e-21 77.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA28445.1 - 2.6e-08 33.7 0.0 1.3e-07 31.5 0.0 2.1 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EEA28445.1 - 0.0081 16.1 0.0 0.021 14.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Cpn10 PF00166.21 EEA28445.1 - 0.024 14.7 0.2 0.18 11.9 0.0 2.4 2 1 1 3 3 3 0 Chaperonin 10 Kd subunit CLP1_N PF16573.5 EEA28447.1 - 5.7e-31 106.6 0.1 3.6e-30 104.0 0.1 2.1 1 1 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor CLP1_P PF16575.5 EEA28447.1 - 2.9e-29 102.2 0.0 1.5e-28 99.8 0.0 2.1 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 EEA28447.1 - 1.5e-24 86.6 0.0 6.1e-24 84.7 0.0 1.9 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.17 EEA28447.1 - 7.3e-05 22.7 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EEA28447.1 - 0.017 15.2 0.1 0.072 13.2 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase SRPRB PF09439.10 EEA28447.1 - 0.025 14.0 0.1 0.52 9.7 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_35 PF14516.6 EEA28447.1 - 0.029 13.2 0.0 0.043 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain ABC_tran PF00005.27 EEA28447.1 - 0.081 13.4 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EEA28447.1 - 0.1 12.3 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EEA28447.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 EEA28447.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family TniB PF05621.11 EEA28447.1 - 0.22 10.9 0.0 0.56 9.6 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein KilA-N PF04383.13 EEA28448.1 - 2.5e-05 24.1 1.5 0.00012 21.9 0.1 2.6 2 1 0 2 2 2 1 KilA-N domain CENP-H PF05837.12 EEA28448.1 - 0.26 11.7 13.2 0.034 14.6 4.5 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) PAXX PF15384.6 EEA28448.1 - 0.72 9.5 12.1 0.021 14.6 4.1 2.1 2 0 0 2 2 2 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Rho_GDI PF02115.17 EEA28449.1 - 1.1e-61 208.1 0.1 1.2e-61 207.9 0.1 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor CopC PF04234.12 EEA28449.1 - 0.086 13.9 0.0 0.15 13.1 0.0 1.4 1 0 0 1 1 1 0 CopC domain Rho_GDI PF02115.17 EEA28450.1 - 1.1e-61 208.1 0.1 1.2e-61 207.9 0.1 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor CopC PF04234.12 EEA28450.1 - 0.086 13.9 0.0 0.15 13.1 0.0 1.4 1 0 0 1 1 1 0 CopC domain Rho_GDI PF02115.17 EEA28451.1 - 2.4e-33 115.5 0.0 2.9e-33 115.3 0.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.28 EEA28452.1 - 2.7e-37 129.3 0.6 4.4e-37 128.6 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA28452.1 - 0.042 14.3 0.4 0.12 12.9 0.4 1.8 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 EEA28452.1 - 0.1 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain VIT1 PF01988.19 EEA28453.1 - 0.27 11.0 0.2 0.45 10.3 0.1 1.3 1 1 0 1 1 1 0 VIT family DUF1387 PF07139.11 EEA28453.1 - 1.2 8.8 9.7 1.7 8.3 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Adaptin_N PF01602.20 EEA28454.1 - 1.4e-102 343.9 0.0 1.8e-102 343.6 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EEA28454.1 - 1e-14 54.9 0.0 6.3e-11 42.6 0.0 3.6 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA28454.1 - 6.3e-09 36.1 0.7 0.00021 21.6 0.0 4.0 2 1 1 3 3 3 3 HEAT repeats HEAT PF02985.22 EEA28454.1 - 6.2e-06 26.0 0.0 0.1 12.9 0.0 4.4 4 0 0 4 4 4 2 HEAT repeat VHS PF00790.19 EEA28454.1 - 0.0063 16.4 0.5 19 5.1 0.0 3.6 3 0 0 3 3 3 0 VHS domain HEAT_EZ PF13513.6 EEA28454.1 - 0.026 15.1 0.6 25 5.5 0.0 4.5 4 0 0 4 4 4 0 HEAT-like repeat Cohesin_HEAT PF12765.7 EEA28454.1 - 0.19 12.1 3.7 2.9 8.3 0.0 3.8 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion CRISPR_Cse2 PF09485.10 EEA28454.1 - 0.26 11.8 4.0 7.5 7.1 0.2 3.3 4 0 0 4 4 4 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Hid1 PF12722.7 EEA28454.1 - 4.3 5.3 10.0 9 4.3 10.0 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YL1 PF05764.13 EEA28454.1 - 7.8 6.5 29.3 0.16 12.0 22.5 1.6 2 0 0 2 2 2 0 YL1 nuclear protein CobT PF06213.12 EEA28454.1 - 8.9 5.6 29.8 10 5.4 21.7 2.4 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Nuf2 PF03800.14 EEA28456.1 - 2.3e-43 147.6 0.1 2.3e-43 147.6 0.1 2.0 2 0 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 EEA28456.1 - 2.2e-34 118.0 21.5 2.2e-34 118.0 21.5 4.3 3 1 1 4 4 4 1 Designed helical repeat protein 10 domain HrpB7 PF09486.10 EEA28456.1 - 0.0034 17.8 18.4 0.0034 17.8 18.4 4.1 1 1 2 3 3 3 1 Bacterial type III secretion protein (HrpB7) P22_AR_C PF10548.9 EEA28456.1 - 0.055 13.6 0.1 7.3 6.8 0.0 2.8 2 0 0 2 2 2 0 P22AR C-terminal domain Spc7 PF08317.11 EEA28456.1 - 1.5 7.6 58.1 0.22 10.4 16.4 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein CreD PF06123.12 EEA28456.1 - 4.6 5.9 7.1 4.7 5.9 6.6 1.4 1 1 0 1 1 1 0 Inner membrane protein CreD DUF4715 PF15835.5 EEA28456.1 - 5.9 7.0 15.1 1.4 9.0 1.9 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4715) IF-2B PF01008.17 EEA28457.1 - 2.2e-49 168.2 0.0 4.4e-49 167.2 0.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family ADH_zinc_N PF00107.26 EEA28458.1 - 1.8e-10 40.9 0.0 3.2e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA28458.1 - 2.7e-07 30.4 0.0 4.9e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EEA28458.1 - 0.0074 17.3 0.0 0.02 15.9 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF1681 PF07933.14 EEA28459.1 - 1.2e-52 177.6 0.0 1.5e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Gemini_C4 PF01492.17 EEA28459.1 - 4.3 7.3 8.2 15 5.6 4.5 2.5 1 1 1 2 2 2 0 Geminivirus C4 protein Thioredoxin PF00085.20 EEA28461.1 - 2.6e-28 98.0 0.1 3.3e-28 97.7 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EEA28461.1 - 2e-06 28.2 0.1 4.7e-06 27.0 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EEA28461.1 - 3e-05 24.3 0.0 0.00013 22.3 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EEA28461.1 - 5.6e-05 22.9 0.0 6.2e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EEA28461.1 - 0.00027 20.4 0.0 0.00035 20.0 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 EEA28461.1 - 0.0017 18.1 0.2 0.23 11.2 0.1 2.1 1 1 1 2 2 2 2 Redoxin AhpC-TSA PF00578.21 EEA28461.1 - 0.016 15.2 0.0 0.047 13.6 0.0 1.7 1 1 0 1 1 1 0 AhpC/TSA family Glutaredoxin PF00462.24 EEA28461.1 - 0.02 15.1 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin HyaE PF07449.11 EEA28461.1 - 0.071 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE DIM1 PF02966.16 EEA28461.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 1 0 1 1 1 0 Mitosis protein DIM1 Thioredoxin PF00085.20 EEA28462.1 - 1e-28 99.3 0.1 1.2e-28 99.1 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EEA28462.1 - 8.9e-07 29.3 0.1 1.9e-06 28.2 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EEA28462.1 - 1.6e-05 25.2 0.0 5.8e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EEA28462.1 - 3.2e-05 23.7 0.0 3.3e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EEA28462.1 - 0.00015 21.3 0.0 0.00017 21.1 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 EEA28462.1 - 0.00075 19.2 0.1 0.16 11.7 0.1 2.0 1 1 1 2 2 2 2 Redoxin AhpC-TSA PF00578.21 EEA28462.1 - 0.0077 16.1 0.0 0.023 14.6 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.24 EEA28462.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.4 1 1 0 1 1 1 0 Glutaredoxin HyaE PF07449.11 EEA28462.1 - 0.041 13.8 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE DIM1 PF02966.16 EEA28462.1 - 0.051 13.3 0.0 0.097 12.5 0.0 1.4 1 1 0 1 1 1 0 Mitosis protein DIM1 Thioredoxin_7 PF13899.6 EEA28462.1 - 0.1 12.8 0.1 0.19 11.9 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_5 PF13743.6 EEA28462.1 - 0.13 11.9 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin MFS_1 PF07690.16 EEA28463.1 - 7.4e-40 136.9 46.8 1e-39 136.5 44.8 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28463.1 - 3.7e-08 32.6 37.1 7.2e-08 31.7 13.1 2.9 2 1 1 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 EEA28463.1 - 3.2 5.9 24.4 0.036 12.4 4.8 3.3 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Acetyltransf_7 PF13508.7 EEA28464.1 - 4.5e-07 30.2 0.0 6.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA28464.1 - 9.9e-06 25.8 0.1 4e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EEA28464.1 - 0.00058 19.8 0.0 0.005 16.8 0.0 2.1 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EEA28464.1 - 0.00063 19.7 0.0 0.0081 16.1 0.0 2.3 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain AMP-binding PF00501.28 EEA28465.1 - 1.9e-38 132.2 0.0 2.8e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EEA28465.1 - 1.2e-10 41.1 1.3 2.2e-10 40.3 0.5 1.9 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus VGLL4 PF15245.6 EEA28467.1 - 0.019 15.0 3.3 0.03 14.4 3.3 1.3 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 Ndc1_Nup PF09531.10 EEA28467.1 - 0.09 11.4 4.7 0.093 11.4 4.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EEA28467.1 - 0.51 9.0 7.2 0.6 8.8 7.2 1.1 1 0 0 1 1 1 0 Presenilin DAO PF01266.24 EEA28468.1 - 1.6e-33 116.8 0.1 1.8e-33 116.6 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 EEA28468.1 - 0.00081 19.6 0.0 0.044 14.0 0.0 3.0 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 EEA28468.1 - 0.0043 16.3 1.2 0.0061 15.8 0.0 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EEA28468.1 - 0.018 15.3 0.0 0.045 14.0 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA28468.1 - 0.026 13.8 0.1 1.6 7.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MRP-S35 PF10246.9 EEA28468.1 - 0.027 14.4 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial ribosomal protein MRP-S35 Glu_dehyd_C PF16912.5 EEA28468.1 - 0.047 13.2 0.1 1.7 8.1 0.1 2.7 2 1 1 3 3 3 0 Glucose dehydrogenase C-terminus Trp_halogenase PF04820.14 EEA28468.1 - 0.32 9.8 1.1 5.7 5.7 0.0 2.6 3 0 0 3 3 3 0 Tryptophan halogenase SNX17_FERM_C PF18116.1 EEA28469.1 - 0.083 13.0 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain ABC_tran PF00005.27 EEA28470.1 - 1.2e-51 174.8 0.0 1.8e-29 103.0 0.0 3.2 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EEA28470.1 - 1.4e-37 129.9 28.6 3.8e-25 89.1 7.3 4.0 4 0 0 4 4 4 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA28470.1 - 1.8e-08 34.1 0.9 0.00018 21.1 0.1 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EEA28470.1 - 0.00025 21.1 0.1 0.12 12.5 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SSE PF00437.20 EEA28470.1 - 0.00042 19.5 0.0 0.065 12.3 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 EEA28470.1 - 0.0007 20.0 2.9 1.2 9.5 0.1 3.5 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA28470.1 - 0.00072 19.5 0.0 0.34 10.8 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EEA28470.1 - 0.0019 18.5 0.9 4.8 7.4 0.0 3.6 3 1 0 3 3 3 2 AAA domain AAA_21 PF13304.6 EEA28470.1 - 0.0035 17.2 0.4 2.8 7.7 0.2 3.4 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EEA28470.1 - 0.004 16.8 0.2 0.96 9.0 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_23 PF13476.6 EEA28470.1 - 0.0081 16.7 0.3 1.3 9.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EEA28470.1 - 0.0095 15.7 4.3 3 7.6 0.1 3.6 4 0 0 4 4 4 2 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EEA28470.1 - 0.017 14.8 0.1 3.3 7.4 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF2075 PF09848.9 EEA28470.1 - 0.018 14.3 0.2 0.31 10.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF87 PF01935.17 EEA28470.1 - 0.053 13.6 3.6 1.2 9.1 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_24 PF13479.6 EEA28470.1 - 0.063 13.0 0.0 0.38 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EEA28470.1 - 0.1 11.6 0.0 0.24 10.3 0.0 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EEA28470.1 - 0.15 11.7 1.4 6.2 6.5 0.0 3.2 3 1 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EEA28470.1 - 0.17 11.2 0.1 5.4 6.3 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin PhoH PF02562.16 EEA28470.1 - 0.17 11.3 0.0 3.3 7.1 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein CbiA PF01656.23 EEA28470.1 - 0.21 11.7 0.8 17 5.5 0.7 2.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zn_clus PF00172.18 EEA28471.1 - 2e-08 34.2 8.2 3.8e-08 33.3 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA28471.1 - 0.018 14.1 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF3288 PF11691.8 EEA28471.1 - 0.077 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3288) NmrA PF05368.13 EEA28472.1 - 2.6e-12 46.8 0.0 4e-11 42.9 0.0 2.1 1 1 1 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EEA28472.1 - 2.2e-11 44.0 0.1 4e-11 43.1 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EEA28472.1 - 0.00093 19.6 0.0 0.0017 18.8 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EEA28472.1 - 0.0012 19.0 0.1 0.0033 17.6 0.0 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EEA28472.1 - 0.002 17.6 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EEA28472.1 - 0.008 16.7 0.1 0.016 15.8 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ldh_1_N PF00056.23 EEA28472.1 - 0.0093 16.1 0.1 0.018 15.1 0.1 1.6 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EEA28472.1 - 0.0093 16.8 0.1 0.017 15.9 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold 3HCDH_N PF02737.18 EEA28472.1 - 0.068 13.1 0.1 0.15 11.9 0.1 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 EEA28472.1 - 0.1 12.0 1.2 0.29 10.6 1.2 1.8 1 1 0 1 1 1 0 short chain dehydrogenase 3Beta_HSD PF01073.19 EEA28472.1 - 0.13 11.3 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF2391 PF09622.10 EEA28472.1 - 0.14 11.5 0.1 0.22 10.8 0.1 1.2 1 0 0 1 1 1 0 Putative integral membrane protein (DUF2391) Polysacc_synt_2 PF02719.15 EEA28472.1 - 0.18 10.9 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein VIT1 PF01988.19 EEA28473.1 - 3.7e-70 236.1 2.4 4.2e-70 236.0 2.4 1.0 1 0 0 1 1 1 1 VIT family OTU PF02338.19 EEA28475.1 - 2.5e-08 34.5 0.0 6.4e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease CUE PF02845.16 EEA28475.1 - 0.0021 17.7 0.2 0.019 14.6 0.1 2.2 2 0 0 2 2 2 1 CUE domain PGA_cap PF09587.10 EEA28476.1 - 1.8e-58 198.0 0.0 3.7e-58 197.0 0.0 1.5 1 1 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap Sugar_tr PF00083.24 EEA28478.1 - 4.5e-18 65.3 13.1 7.1e-16 58.1 13.1 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter GATA PF00320.27 EEA28479.1 - 1.5e-28 98.0 19.5 1.3e-14 53.4 6.8 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EEA28479.1 - 1.9e-06 27.3 3.7 0.0013 18.2 0.1 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EEA28479.1 - 1.7e-05 24.8 2.2 0.071 13.2 0.2 2.8 2 0 0 2 2 2 2 Zinc ribbon domain Auto_anti-p27 PF06677.12 EEA28479.1 - 0.00088 19.4 4.8 0.071 13.3 0.2 2.7 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) OrfB_Zn_ribbon PF07282.11 EEA28479.1 - 0.014 15.3 5.5 0.3 11.0 0.5 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DZR PF12773.7 EEA28479.1 - 0.026 14.5 11.4 20 5.3 11.5 3.1 1 1 0 1 1 1 0 Double zinc ribbon eIF-5_eIF-2B PF01873.17 EEA28479.1 - 0.035 14.0 4.0 2.9 7.8 0.2 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 ArfGap PF01412.18 EEA28479.1 - 0.094 12.8 4.1 0.43 10.7 0.1 2.4 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Rubredoxin_2 PF18073.1 EEA28479.1 - 1.3 8.8 9.5 16 5.4 0.2 4.5 4 0 0 4 4 4 0 Rubredoxin metal binding domain Nudix_N_2 PF14803.6 EEA28479.1 - 5 7.1 11.6 6.9 6.7 2.5 3.4 2 1 1 3 3 3 0 Nudix N-terminal Ferritin PF00210.24 EEA28480.1 - 1.2e-12 47.9 0.0 1.6e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Cu-oxidase_2 PF07731.14 EEA28482.1 - 8.2e-42 142.2 2.7 8.2e-42 142.2 2.7 2.7 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EEA28482.1 - 6.9e-39 132.6 3.5 6.9e-39 132.6 3.5 3.4 4 1 1 5 5 5 1 Multicopper oxidase Cu-oxidase PF00394.22 EEA28482.1 - 5.1e-36 124.2 6.5 1.8e-35 122.4 0.9 3.2 3 0 0 3 3 3 1 Multicopper oxidase Kelch_1 PF01344.25 EEA28483.1 - 4.4e-09 35.8 1.5 5.6e-06 25.8 0.0 3.9 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 EEA28483.1 - 2.5e-05 24.4 7.3 0.0029 17.8 0.1 5.2 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 EEA28483.1 - 0.00026 20.9 12.1 0.00043 20.2 1.1 4.5 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EEA28483.1 - 0.00062 20.0 13.6 0.0038 17.5 0.7 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EEA28483.1 - 0.0022 18.0 11.8 0.094 12.7 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Alpha_GJ PF03229.13 EEA28483.1 - 0.033 14.7 1.7 0.1 13.2 1.7 1.8 1 0 0 1 1 1 0 Alphavirus glycoprotein J Kelch_2 PF07646.15 EEA28483.1 - 0.069 13.2 5.2 21 5.3 0.0 4.9 5 0 0 5 5 5 0 Kelch motif Staphylcoagulse PF04022.12 EEA28483.1 - 0.13 11.8 2.5 0.44 10.1 2.5 1.9 1 0 0 1 1 1 0 Staphylocoagulase repeat COPI_assoc PF08507.10 EEA28485.1 - 4.8e-30 104.3 6.8 5.2e-30 104.2 6.8 1.0 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.9 EEA28485.1 - 0.38 11.1 6.0 0.71 10.2 5.7 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P DUF2892 PF11127.8 EEA28485.1 - 4.4 7.4 14.1 8.5 6.5 5.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2892) adh_short PF00106.25 EEA28486.1 - 2.4e-53 180.5 0.2 3.3e-53 180.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28486.1 - 1.5e-35 122.9 0.1 2e-35 122.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA28486.1 - 7.2e-13 48.8 0.0 1.1e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EEA28486.1 - 6.8e-05 22.1 0.2 0.00012 21.3 0.2 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EEA28486.1 - 0.00075 19.8 0.1 0.0015 18.8 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EEA28486.1 - 0.03 14.4 0.9 0.099 12.7 0.2 2.1 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Ras PF00071.22 EEA28487.1 - 7.2e-60 201.3 0.2 8.4e-60 201.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA28487.1 - 1.4e-20 73.7 0.0 2.1e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA28487.1 - 9.6e-09 34.9 0.0 1.1e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA28487.1 - 1.2e-06 28.2 0.2 9.5e-06 25.3 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA28487.1 - 5.7e-05 23.1 0.7 0.24 11.3 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EEA28487.1 - 0.0019 18.2 0.0 0.003 17.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EEA28487.1 - 0.0071 16.4 0.0 0.015 15.3 0.0 1.6 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EEA28487.1 - 0.01 15.3 0.0 0.019 14.5 0.0 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B Ser_hydrolase PF06821.13 EEA28487.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase IstB_IS21 PF01695.17 EEA28487.1 - 0.17 11.6 0.8 2.4 7.9 0.2 2.2 1 1 1 2 2 2 0 IstB-like ATP binding protein ATP_bind_1 PF03029.17 EEA28487.1 - 0.5 10.1 2.2 4.2 7.1 0.1 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein MoCF_biosynth PF00994.24 EEA28488.1 - 9.5e-33 112.9 0.0 1.8e-32 112.0 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain CinA_KH PF18146.1 EEA28488.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Damage-inducible protein CinA KH domain Cofilin_ADF PF00241.20 EEA28489.1 - 2.5e-19 69.3 0.0 2.9e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF1887 PF09002.11 EEA28489.1 - 0.026 13.2 0.0 0.43 9.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1887) NAD_binding_10 PF13460.6 EEA28490.1 - 2.5e-13 50.3 0.5 8.5e-12 45.3 0.1 2.1 1 1 1 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EEA28490.1 - 2.1e-12 47.1 1.2 8.7e-11 41.8 0.4 2.1 1 1 1 2 2 2 2 NmrA-like family Sacchrp_dh_NADP PF03435.18 EEA28490.1 - 5.3e-06 26.7 0.1 7.6e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EEA28490.1 - 0.002 17.6 0.1 0.003 17.0 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA28490.1 - 0.011 14.9 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein 3Beta_HSD PF01073.19 EEA28490.1 - 0.016 14.2 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 EEA28490.1 - 0.089 12.8 0.0 0.19 11.8 0.0 1.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 EEA28490.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fungal_trans PF04082.18 EEA28491.1 - 1.2e-13 50.8 2.8 2.1e-13 49.9 2.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain PBP1_TM PF14812.6 EEA28491.1 - 0.023 15.1 0.6 0.044 14.2 0.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zn_ribbon_17 PF17120.5 EEA28492.1 - 0.005 16.4 3.5 0.005 16.4 3.5 2.9 3 0 0 3 3 3 2 Zinc-ribbon, C4HC2 type DZR PF12773.7 EEA28492.1 - 0.023 14.7 28.1 0.087 12.9 11.3 3.6 2 2 1 3 3 3 0 Double zinc ribbon SWIRM-assoc_2 PF16496.5 EEA28492.1 - 0.031 13.2 0.6 0.044 12.7 0.6 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal FYVE_2 PF02318.16 EEA28492.1 - 0.26 11.5 21.1 0.67 10.2 1.8 3.4 3 0 0 3 3 3 0 FYVE-type zinc finger Siva PF05458.12 EEA28492.1 - 1.8 8.2 20.2 0.44 10.2 3.4 3.2 3 0 0 3 3 3 0 Cd27 binding protein (Siva) Zn_ribbon_17 PF17120.5 EEA28493.1 - 0.0046 16.6 3.5 0.0046 16.6 3.5 2.9 3 0 0 3 3 3 2 Zinc-ribbon, C4HC2 type DZR PF12773.7 EEA28493.1 - 0.015 15.3 27.9 0.058 13.4 10.9 3.6 2 2 1 3 3 3 0 Double zinc ribbon SWIRM-assoc_2 PF16496.5 EEA28493.1 - 0.028 13.3 0.6 0.039 12.8 0.6 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal FYVE_2 PF02318.16 EEA28493.1 - 0.14 12.4 20.7 0.61 10.3 1.8 3.3 3 0 0 3 3 3 0 FYVE-type zinc finger Siva PF05458.12 EEA28493.1 - 1.2 8.8 19.9 0.41 10.3 3.4 3.3 3 0 0 3 3 3 0 Cd27 binding protein (Siva) HypA PF01155.19 EEA28493.1 - 7.2 6.7 22.1 6 6.9 3.9 3.4 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ank_2 PF12796.7 EEA28494.1 - 3.1e-23 82.1 0.0 7.5e-13 48.9 0.0 3.1 2 1 1 3 3 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA28494.1 - 2e-21 76.0 0.3 3.5e-09 37.0 0.0 4.6 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA28494.1 - 4.2e-21 74.7 0.0 5.2e-08 33.0 0.0 4.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA28494.1 - 4.1e-17 61.8 0.9 5.6e-06 26.6 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EEA28494.1 - 1.2e-15 56.0 0.0 1.3e-05 25.1 0.0 5.4 4 0 0 4 4 4 2 Ankyrin repeat NACHT PF05729.12 EEA28494.1 - 1.1e-05 25.5 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EEA28494.1 - 0.0016 18.7 0.0 0.0062 16.8 0.0 2.1 1 0 0 1 1 1 1 AAA domain PGAP1 PF07819.13 EEA28494.1 - 0.0041 16.9 0.0 0.0083 15.9 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein AAA_16 PF13191.6 EEA28494.1 - 0.0041 17.5 0.7 0.041 14.3 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 EEA28494.1 - 0.0042 16.3 0.0 0.0097 15.1 0.0 1.6 1 1 0 1 1 1 1 NB-ARC domain Hydrolase_4 PF12146.8 EEA28494.1 - 0.0054 16.0 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 EEA28494.1 - 0.0084 15.6 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Cutinase PF01083.22 EEA28494.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Cutinase ATPase PF06745.13 EEA28494.1 - 0.082 12.2 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 KaiC Sugar_tr PF00083.24 EEA28495.1 - 1.1e-76 258.5 26.3 1.3e-76 258.4 26.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA28495.1 - 3.6e-29 101.8 47.1 9.7e-23 80.6 24.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EEA28495.1 - 0.0011 17.5 2.3 0.0011 17.5 2.3 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Synaptobrevin PF00957.21 EEA28495.1 - 0.11 12.3 1.2 1.9 8.3 0.0 2.9 2 0 0 2 2 2 0 Synaptobrevin Glyco_hydro_43 PF04616.14 EEA28496.1 - 1.4e-74 251.0 0.7 1.9e-74 250.6 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EEA28496.1 - 1.1e-11 44.9 0.0 1.7e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain NDUF_C2 PF06374.11 EEA28497.1 - 0.15 12.2 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Abhydrolase_3 PF07859.13 EEA28498.1 - 1.3e-34 119.9 0.0 1.5e-34 119.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 EEA28498.1 - 3.8e-10 39.7 0.0 0.00083 19.0 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EEA28498.1 - 2.7e-06 27.0 0.0 1.8e-05 24.3 0.0 2.2 2 1 0 2 2 2 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EEA28498.1 - 5e-05 23.3 0.0 0.00036 20.5 0.0 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 EEA28498.1 - 0.00069 19.3 0.0 0.0024 17.6 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EEA28498.1 - 0.00094 19.8 0.4 0.0032 18.1 0.4 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EEA28498.1 - 0.0044 16.7 0.0 0.014 15.0 0.0 1.7 2 0 0 2 2 2 1 Putative esterase COesterase PF00135.28 EEA28498.1 - 0.0069 15.3 0.0 0.019 13.8 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 EEA28498.1 - 0.0069 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF2974 PF11187.8 EEA28498.1 - 0.02 14.5 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EEA28498.1 - 0.076 12.3 0.0 0.2 10.9 0.0 1.6 1 1 0 2 2 2 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EEA28498.1 - 0.19 10.6 0.0 0.29 10.0 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme SNF2_N PF00176.23 EEA28499.1 - 2.1e-54 184.6 0.0 3.6e-54 183.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA28499.1 - 2.2e-12 47.3 0.1 7.1e-12 45.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA28499.1 - 3e-07 30.6 0.0 6.8e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EEA28499.1 - 0.0008 18.7 0.2 0.0016 17.7 0.2 1.5 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD PF00628.29 EEA28499.1 - 0.0025 17.7 13.9 0.21 11.5 2.2 2.7 1 1 1 2 2 2 2 PHD-finger SWI2_SNF2 PF18766.1 EEA28499.1 - 0.066 12.9 0.0 0.34 10.6 0.0 2.1 1 1 0 1 1 1 0 SWI2/SNF2 ATPase DEAD_2 PF06733.15 EEA28499.1 - 0.094 12.3 0.8 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 DEAD_2 AvrPtoB_bdg PF16847.5 EEA28499.1 - 0.15 12.6 0.0 0.41 11.1 0.0 1.8 1 0 0 1 1 1 0 Avirulence AvrPtoB, BAK1-binding domain DIOX_N PF14226.6 EEA28500.1 - 1.6e-13 51.5 0.0 2.7e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA28500.1 - 8e-12 45.5 0.0 1.6e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UPF0086 PF01868.16 EEA28501.1 - 3.4e-32 110.2 0.2 6e-32 109.4 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Lactonase PF10282.9 EEA28501.1 - 0.029 13.6 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller tRNA_int_endo PF01974.17 EEA28502.1 - 1.6e-17 63.4 0.1 9e-17 60.9 0.0 2.0 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain DUF4770 PF15994.5 EEA28502.1 - 0.15 12.3 2.2 0.22 11.8 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Luteo_PO PF04662.13 EEA28503.1 - 0.098 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Luteovirus P0 protein PLDc_N PF13396.6 EEA28503.1 - 0.53 10.3 8.4 0.84 9.6 8.4 1.3 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal PAXNEB PF05625.11 EEA28504.1 - 2.1e-115 385.8 0.0 2.4e-115 385.6 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein RNA_pol_Rpb8 PF03870.15 EEA28505.1 - 5.2e-45 153.1 0.0 5.8e-45 152.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 NUDIX PF00293.28 EEA28506.1 - 1.3e-13 51.1 0.2 2.6e-13 50.2 0.2 1.5 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 EEA28506.1 - 5.9e-11 42.4 0.0 8.7e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) DUF775 PF05603.12 EEA28507.1 - 6.9e-71 237.9 0.0 7.7e-71 237.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) GATase PF00117.28 EEA28508.1 - 1.1e-11 44.8 0.0 1.5e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EEA28508.1 - 0.0077 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain MFS_1 PF07690.16 EEA28509.1 - 4.4e-43 147.6 40.8 1.5e-42 145.8 40.4 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EEA28509.1 - 2.4e-10 39.5 17.2 3.3e-10 39.0 17.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans_2 PF11951.8 EEA28510.1 - 1.1e-08 34.3 7.6 9.5e-08 31.2 7.6 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28510.1 - 9.2e-07 28.9 10.0 2.7e-06 27.4 10.0 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EEA28511.1 - 5.7e-48 163.3 8.2 5.7e-48 163.3 8.2 1.5 2 0 0 2 2 2 1 RTA1 like protein 7TM_GPCR_Str PF10326.9 EEA28511.1 - 0.014 14.8 15.0 0.02 14.3 15.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str Fungal_trans_2 PF11951.8 EEA28512.1 - 4.7e-05 22.4 0.3 6.3e-05 21.9 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28512.1 - 0.00084 19.4 1.3 0.0016 18.5 1.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Whib PF02467.16 EEA28512.1 - 0.18 12.4 1.2 0.57 10.8 1.2 1.8 1 0 0 1 1 1 0 Transcription factor WhiB WD40 PF00400.32 EEA28513.1 - 3.9e-12 46.5 2.6 0.002 18.9 0.1 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28513.1 - 0.0015 18.8 0.7 7 7.0 0.1 3.8 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1214 PF06742.11 EEA28513.1 - 0.015 15.7 0.5 1.1 9.8 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1214) DEAD PF00270.29 EEA28514.1 - 1.1e-42 145.7 0.0 1.7e-42 145.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA28514.1 - 2.4e-20 72.9 0.0 1.2e-19 70.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA28514.1 - 2e-17 63.1 0.2 5.5e-17 61.7 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EEA28514.1 - 3.3e-05 24.0 0.0 8.9e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA28514.1 - 0.063 12.5 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF1045 PF06299.12 EEA28514.1 - 0.086 12.8 0.1 0.26 11.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) C9orf72-like PF15019.6 EEA28515.1 - 0.03 13.9 0.1 0.049 13.2 0.1 1.2 1 0 0 1 1 1 0 C9orf72-like protein family Pyridox_oxase_2 PF12766.7 EEA28516.1 - 2.8e-29 101.6 0.0 5.6e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FlgM PF04316.13 EEA28516.1 - 0.027 14.8 0.0 1.9 8.9 0.0 2.4 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM Putative_PNPOx PF01243.20 EEA28516.1 - 0.029 14.6 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase LRR_9 PF14580.6 EEA28519.1 - 8.7e-60 201.2 0.1 1.3e-59 200.6 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EEA28519.1 - 3.8e-06 26.6 1.0 3.8e-06 26.6 1.0 2.3 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EEA28519.1 - 7.4e-06 26.2 5.4 0.00039 20.7 1.2 3.4 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) HTH_38 PF13936.6 EEA28519.1 - 0.0033 17.2 0.7 0.0063 16.3 0.7 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4349 PF14257.6 EEA28519.1 - 0.034 13.6 1.9 0.058 12.8 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) HTH_32 PF13565.6 EEA28519.1 - 0.054 14.1 0.4 0.11 13.1 0.4 1.5 1 0 0 1 1 1 0 Homeodomain-like domain GDA1_CD39 PF01150.17 EEA28520.1 - 1.1e-105 353.8 0.0 1.4e-105 353.4 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family p450 PF00067.22 EEA28521.1 - 1.4e-37 129.5 0.0 1.9e-37 129.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Dynamitin PF04912.14 EEA28522.1 - 0.0078 15.6 3.8 0.01 15.2 3.8 1.2 1 0 0 1 1 1 1 Dynamitin Atg14 PF10186.9 EEA28522.1 - 0.055 12.6 1.9 0.063 12.4 1.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 W_rich_C PF07483.11 EEA28522.1 - 0.094 12.9 0.5 6.1 7.1 0.0 2.4 1 1 1 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain DUF5446 PF17522.2 EEA28522.1 - 0.14 12.3 3.9 0.42 10.8 3.9 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5446) FAM76 PF16046.5 EEA28522.1 - 0.19 11.1 4.5 0.24 10.7 4.5 1.2 1 0 0 1 1 1 0 FAM76 protein SlyX PF04102.12 EEA28522.1 - 0.78 10.4 5.7 0.55 10.9 3.8 1.8 2 0 0 2 2 2 0 SlyX DUF4145 PF13643.6 EEA28522.1 - 1.3 9.2 9.5 60 3.9 4.5 3.7 4 1 0 4 4 4 0 Domain of unknown function (DUF4145) DUF883 PF05957.13 EEA28522.1 - 1.9 9.1 7.3 0.21 12.2 2.3 2.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 EEA28522.1 - 2.6 8.6 6.3 12 6.5 5.4 2.5 2 1 0 2 2 2 0 YtxH-like protein MFS_1 PF07690.16 EEA28523.1 - 2.5e-33 115.5 41.7 2.5e-33 115.5 41.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Adeno_E4_34 PF04528.13 EEA28523.1 - 0.033 14.0 0.3 0.071 13.0 0.3 1.5 1 0 0 1 1 1 0 Adenovirus early E4 34 kDa protein conserved region Flg_new PF09479.10 EEA28523.1 - 0.23 11.7 2.3 0.41 10.9 0.1 2.3 2 0 0 2 2 2 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) Abhydrolase_3 PF07859.13 EEA28524.1 - 4.4e-09 36.5 0.0 6.2e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA28524.1 - 1.2e-08 34.7 0.0 8.6e-06 25.4 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 EEA28524.1 - 0.00069 19.2 0.0 0.069 12.7 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EEA28524.1 - 0.00086 19.2 0.0 0.033 14.0 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EEA28524.1 - 0.0025 17.1 0.0 0.006 15.9 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 FSH1 PF03959.13 EEA28524.1 - 0.044 13.4 0.0 0.067 12.8 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Thioesterase PF00975.20 EEA28524.1 - 0.091 12.9 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Chlorophyllase2 PF12740.7 EEA28524.1 - 0.21 10.5 0.0 0.29 10.0 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase enzyme Methyltransf_12 PF08242.12 EEA28525.1 - 6e-12 46.2 0.0 9.5e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA28525.1 - 8.5e-10 38.7 0.0 1.1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA28525.1 - 2.9e-09 36.9 0.0 3.7e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA28525.1 - 3.1e-08 34.2 0.0 5e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.17 EEA28525.1 - 9.8e-07 28.7 0.0 1.8e-06 27.8 0.0 1.4 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_11 PF08241.12 EEA28525.1 - 7.5e-06 26.5 0.0 1.1e-05 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EEA28525.1 - 0.00014 21.0 0.0 0.00021 20.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_33 PF10017.9 EEA28525.1 - 0.00016 21.0 0.0 0.00021 20.5 0.0 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Ubie_methyltran PF01209.18 EEA28525.1 - 0.00017 21.0 0.0 0.00035 20.0 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EEA28525.1 - 0.01 15.6 0.1 0.063 13.0 0.0 2.0 1 1 1 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 EEA28525.1 - 0.036 13.8 0.4 0.27 10.9 0.4 2.0 1 1 0 1 1 1 0 Lysine methyltransferase DREV PF05219.12 EEA28525.1 - 0.079 12.0 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase Zn_clus PF00172.18 EEA28526.1 - 6.1e-09 35.9 12.2 6.1e-09 35.9 12.2 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABM PF03992.16 EEA28527.1 - 6.3e-09 35.8 0.1 7.3e-09 35.6 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Ammonium_transp PF00909.21 EEA28528.1 - 2.4e-111 372.3 29.1 2.8e-111 372.0 29.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family p450 PF00067.22 EEA28529.1 - 4.5e-13 48.8 0.2 5.5e-13 48.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Acyltransferase PF01553.21 EEA28530.1 - 6.1e-17 61.5 0.0 1.2e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Pantoate_ligase PF02569.15 EEA28531.1 - 1.3e-93 313.1 0.0 1.5e-93 312.9 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase ATP-sulfurylase PF01747.17 EEA28531.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 ATP-sulfurylase SBP_bac_1 PF01547.25 EEA28531.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein DASH_Dad2 PF08654.10 EEA28532.1 - 0.031 14.7 0.6 0.11 12.9 0.1 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad2 RSN1_7TM PF02714.15 EEA28534.1 - 1.5e-88 296.7 18.6 1.5e-88 296.7 18.6 2.9 4 0 0 4 4 4 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EEA28534.1 - 1.6e-45 154.7 4.1 1.6e-45 154.7 4.1 2.9 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EEA28534.1 - 1e-40 139.9 1.9 1.6e-40 139.2 1.9 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EEA28534.1 - 2.2e-32 111.1 0.2 2.2e-32 111.1 0.2 2.5 3 0 0 3 3 3 1 Extracellular tail, of 10TM putative phosphate transporter DUF1192 PF06698.11 EEA28534.1 - 0.21 11.7 2.0 0.62 10.2 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) MCM PF00493.23 EEA28536.1 - 3.5e-101 337.0 0.1 5.8e-101 336.3 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA28536.1 - 1.4e-38 131.5 0.2 3.3e-38 130.4 0.2 1.6 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EEA28536.1 - 7.6e-32 109.8 0.5 7.6e-32 109.8 0.5 2.8 3 0 0 3 3 3 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EEA28536.1 - 5.1e-24 84.5 1.2 9.6e-24 83.6 0.5 1.9 2 0 0 2 2 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA28536.1 - 8.5e-23 80.9 2.1 8.5e-23 80.9 2.1 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EEA28536.1 - 1e-07 31.5 0.0 7.3e-07 28.8 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EEA28536.1 - 0.0023 17.8 0.0 0.0057 16.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EEA28536.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain GIDA_assoc PF13932.6 EEA28536.1 - 0.025 14.8 2.1 0.067 13.4 2.1 1.8 1 0 0 1 1 1 0 GidA associated domain AAA_5 PF07728.14 EEA28536.1 - 0.039 14.0 0.0 0.1 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Nuf2 PF03800.14 EEA28536.1 - 0.13 12.3 1.1 2 8.5 0.0 2.8 3 0 0 3 3 3 0 Nuf2 family T4SS PF07996.11 EEA28536.1 - 1.4 9.3 6.8 0.23 11.8 0.6 2.6 3 0 0 3 3 3 0 Type IV secretion system proteins SNF2_N PF00176.23 EEA28537.1 - 1.5e-47 162.0 0.1 2.5e-47 161.3 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA28537.1 - 9.8e-12 45.2 0.0 2.7e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain She9_MDM33 PF05546.11 EEA28538.1 - 6.1e-88 293.8 8.3 9.4e-88 293.2 8.3 1.3 1 0 0 1 1 1 1 She9 / Mdm33 family PsbH PF00737.20 EEA28538.1 - 0.062 13.0 1.0 0.12 12.1 1.0 1.4 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein AAA_21 PF13304.6 EEA28538.1 - 0.13 12.0 1.7 5.8 6.6 0.0 2.7 1 1 2 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system OEP PF02321.18 EEA28538.1 - 5.8 6.7 18.0 11 5.8 13.6 2.6 2 1 0 2 2 2 0 Outer membrane efflux protein DUF2524 PF10732.9 EEA28538.1 - 6.5 7.1 8.0 2.8 8.3 1.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) Pmp3 PF01679.17 EEA28539.1 - 1e-18 67.2 11.6 1.3e-18 66.9 11.6 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator SH3_9 PF14604.6 EEA28540.1 - 0.00015 21.5 0.2 0.00031 20.5 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EEA28540.1 - 0.00026 20.6 0.2 0.00049 19.6 0.2 1.5 1 0 0 1 1 1 1 SH3 domain Syndecan PF01034.20 EEA28540.1 - 0.018 14.9 0.6 0.037 13.9 0.6 1.4 1 0 0 1 1 1 0 Syndecan domain FAM104 PF15434.6 EEA28540.1 - 0.033 14.8 1.3 0.88 10.2 0.0 3.0 3 1 0 3 3 3 0 Family 104 Glycophorin_A PF01102.18 EEA28540.1 - 0.04 14.1 0.0 0.092 13.0 0.0 1.6 1 0 0 1 1 1 0 Glycophorin A Mid2 PF04478.12 EEA28540.1 - 0.049 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Nitrate_red_gam PF02665.14 EEA28540.1 - 0.062 12.8 0.1 0.1 12.2 0.1 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Lyase_aromatic PF00221.19 EEA28541.1 - 1e-157 525.6 5.3 3e-157 524.0 4.9 1.7 2 0 0 2 2 2 1 Aromatic amino acid lyase PI3_PI4_kinase PF00454.27 EEA28542.1 - 1e-51 176.2 0.1 3.7e-51 174.4 0.1 2.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EEA28542.1 - 1.8e-46 158.0 0.7 1.8e-46 158.0 0.7 2.7 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 EEA28542.1 - 4.5e-12 45.6 0.6 1.4e-11 44.0 0.1 2.2 2 0 0 2 2 2 1 FATC domain FAT PF02259.23 EEA28542.1 - 0.00014 21.2 6.8 0.00014 21.2 6.8 2.1 2 0 0 2 2 2 1 FAT domain Nup192 PF11894.8 EEA28543.1 - 0 1335.5 24.2 0 1335.1 24.2 1.1 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Cullin PF00888.22 EEA28543.1 - 5.3e-182 606.7 6.5 1e-181 605.8 6.5 1.5 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EEA28543.1 - 2.1e-22 78.9 2.9 2.1e-22 78.9 2.9 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF4704 PF15787.5 EEA28543.1 - 0.011 14.9 0.1 0.051 12.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4704) Dak1 PF02733.17 EEA28544.1 - 9.2e-107 356.5 0.2 1.2e-106 356.2 0.2 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EEA28544.1 - 1.1e-45 155.7 1.6 1.1e-45 155.7 1.6 1.7 2 0 0 2 2 2 1 DAK2 domain Csm1_B PF18211.1 EEA28544.1 - 0.11 12.4 0.0 0.4 10.6 0.0 1.9 2 0 0 2 2 2 0 Csm1 subunit domain B LSM PF01423.22 EEA28545.1 - 5.7e-19 67.6 0.1 7.7e-19 67.2 0.1 1.2 1 0 0 1 1 1 1 LSM domain LSM PF01423.22 EEA28546.1 - 6e-13 48.3 0.0 8.8e-13 47.7 0.0 1.2 1 0 0 1 1 1 1 LSM domain SNF2_N PF00176.23 EEA28547.1 - 9.9e-69 231.7 0.4 1.4e-68 231.2 0.4 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA28547.1 - 4.6e-15 55.9 0.1 1.8e-14 54.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA28547.1 - 9.6e-11 41.8 0.0 3.3e-10 40.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA28547.1 - 1.5e-08 34.8 0.1 1e-07 32.2 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 EEA28547.1 - 1.5e-06 28.0 4.8 2.8e-06 27.2 4.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA28547.1 - 0.00059 19.6 6.2 0.0012 18.6 6.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SWI2_SNF2 PF18766.1 EEA28547.1 - 0.0082 15.8 0.0 0.28 10.8 0.0 2.4 2 0 0 2 2 2 1 SWI2/SNF2 ATPase zf-RING_2 PF13639.6 EEA28547.1 - 0.012 15.9 6.3 0.025 14.9 6.3 1.6 1 0 0 1 1 1 0 Ring finger domain FYVE_2 PF02318.16 EEA28547.1 - 0.027 14.7 1.0 0.072 13.3 1.0 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger zf-C3HC4_3 PF13920.6 EEA28547.1 - 0.028 14.3 8.0 0.063 13.2 7.2 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA28547.1 - 0.48 10.5 5.5 0.53 10.4 1.7 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA28547.1 - 0.69 9.8 5.7 1.5 8.8 5.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA28547.1 - 1.2 9.0 7.3 3.5 7.5 6.1 2.4 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PNP_UDP_1 PF01048.20 EEA28548.1 - 5.1e-08 32.4 0.1 3e-07 29.9 0.1 2.1 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 EEA28548.1 - 7.5e-08 32.5 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA28548.1 - 0.00072 20.0 0.0 0.0026 18.2 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA28548.1 - 0.0037 17.5 0.1 0.23 11.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain zf-BED PF02892.15 EEA28548.1 - 0.027 14.5 0.2 15 5.7 0.0 3.1 2 0 0 2 2 2 0 BED zinc finger AAA PF00004.29 EEA28548.1 - 0.028 14.9 0.0 0.17 12.3 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) zf-C2H2_12 PF18658.1 EEA28548.1 - 0.032 13.8 0.6 7.6 6.2 0.0 2.8 2 0 0 2 2 2 0 Zinc-finger C2H2-type PIF1 PF05970.14 EEA28548.1 - 0.071 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 PIF1-like helicase PhoH PF02562.16 EEA28548.1 - 0.077 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.9 EEA28548.1 - 0.097 11.9 0.0 0.21 10.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EEA28548.1 - 0.17 11.6 0.1 0.49 10.1 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein zf-C2H2 PF00096.26 EEA28548.1 - 7.9 7.2 19.4 1.3 9.6 1.5 5.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type GATA PF00320.27 EEA28549.1 - 0.00013 21.4 5.8 0.015 14.9 1.9 2.6 2 0 0 2 2 2 2 GATA zinc finger Las1 PF04031.13 EEA28550.1 - 8.1e-45 152.7 0.0 3.2e-44 150.7 0.0 1.9 2 0 0 2 2 2 1 Las1-like NAD_kinase PF01513.21 EEA28552.1 - 7.5e-71 238.7 0.0 1.1e-70 238.1 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EEA28552.1 - 0.19 11.4 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 EEA28553.1 - 4.1e-64 216.6 0.0 6e-64 216.0 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EEA28553.1 - 0.17 11.5 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 EEA28554.1 - 1.1e-31 110.1 0.0 1.7e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EEA28554.1 - 0.13 11.8 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain TRAPP PF04051.16 EEA28555.1 - 4.3e-41 140.1 0.0 6.1e-41 139.5 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component MFAP1 PF06991.11 EEA28556.1 - 2.8e-67 226.8 29.8 2.8e-67 226.8 29.8 4.1 2 2 1 3 3 3 1 Microfibril-associated/Pre-mRNA processing Rep_fac-A_3 PF08661.11 EEA28557.1 - 2e-28 98.8 0.0 2.3e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 HAGH_C PF16123.5 EEA28558.1 - 1.6e-19 70.2 0.1 3.2e-19 69.2 0.1 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EEA28558.1 - 6.5e-18 65.4 1.3 4.6e-16 59.4 1.3 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA28558.1 - 0.0031 17.1 1.2 0.035 13.6 1.2 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF1264 PF06884.11 EEA28559.1 - 1.5e-75 252.5 0.0 1.8e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) Peptidase_S26 PF10502.9 EEA28560.1 - 1.2e-05 25.1 0.0 0.00091 19.0 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EEA28560.1 - 3.4e-05 23.7 0.1 9.5e-05 22.3 0.1 1.7 2 0 0 2 2 2 1 Peptidase S24-like PBP PF01161.20 EEA28561.1 - 4.4e-11 43.2 0.0 7.1e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Sld5 PF05916.11 EEA28561.1 - 0.08 13.4 0.1 0.15 12.6 0.1 1.6 1 0 0 1 1 1 0 GINS complex protein Ribosomal_L4 PF00573.22 EEA28562.1 - 2.6e-48 164.2 0.0 3.4e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family ECH_2 PF16113.5 EEA28563.1 - 1.2e-132 442.5 0.0 1.7e-132 442.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EEA28563.1 - 7.7e-26 90.9 0.0 9.2e-25 87.4 0.0 2.1 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Death PF00531.22 EEA28563.1 - 0.02 15.0 0.0 0.16 12.1 0.0 2.3 2 0 0 2 2 2 0 Death domain Peptidase_M24 PF00557.24 EEA28564.1 - 1.1e-45 155.9 0.0 1.7e-45 155.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EEA28564.1 - 2.1e-05 25.2 0.0 5.9e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain UPF0180 PF03698.13 EEA28564.1 - 0.12 12.5 0.2 0.44 10.8 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) Peptidase_M24 PF00557.24 EEA28565.1 - 6.4e-46 156.7 0.0 1e-45 156.0 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EEA28565.1 - 1.2e-05 25.9 0.0 3.9e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain UPF0180 PF03698.13 EEA28565.1 - 0.1 12.8 0.2 0.33 11.1 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) bZIP_1 PF00170.21 EEA28566.1 - 1.7e-10 40.8 10.2 3.2e-10 40.0 10.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EEA28566.1 - 5.3e-06 26.4 8.5 1.4e-05 25.1 8.5 1.8 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EEA28566.1 - 0.0044 17.5 4.4 0.011 16.2 4.4 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor RVT_2 PF07727.14 EEA28567.1 - 8.7e-11 41.9 0.0 1.5e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA28567.1 - 1.6e-06 28.3 0.0 4.6e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain CBS PF00571.28 EEA28570.1 - 3.1e-22 78.8 6.6 1.3e-09 38.3 0.1 4.3 4 0 0 4 4 4 4 CBS domain DUF5066 PF16728.5 EEA28570.1 - 0.022 14.1 0.1 0.19 11.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5066) CRAL_TRIO PF00650.20 EEA28571.1 - 5.9e-40 136.6 0.0 8.4e-40 136.1 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA28571.1 - 5.6e-18 64.9 0.0 9.9e-18 64.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EEA28571.1 - 7.2e-05 23.0 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pol_alpha_B_N PF08418.10 EEA28572.1 - 6e-78 262.2 0.0 8e-78 261.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EEA28572.1 - 6e-37 127.1 0.0 8.9e-37 126.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B IpaB_EvcA PF03278.13 EEA28572.1 - 0.17 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 IpaB/EvcA family Apc13p PF05839.11 EEA28573.1 - 7.5e-18 64.5 0.1 6e-14 52.0 0.0 2.1 2 0 0 2 2 2 2 Apc13p protein IF-2B PF01008.17 EEA28574.1 - 2e-73 247.1 0.5 2.5e-73 246.7 0.5 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Ndc1_Nup PF09531.10 EEA28574.1 - 0.82 8.3 4.1 1.1 7.9 4.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Kinesin PF00225.23 EEA28575.1 - 4.1e-113 377.7 0.4 6.9e-113 376.9 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EEA28575.1 - 1.8e-25 89.7 2.3 2.6e-25 89.1 0.0 2.4 3 0 0 3 3 3 1 Microtubule binding HlyD_2 PF12700.7 EEA28575.1 - 0.16 10.6 2.7 0.27 9.9 2.7 1.2 1 0 0 1 1 1 0 HlyD family secretion protein Spc7 PF08317.11 EEA28575.1 - 0.38 9.6 14.0 0.019 13.9 8.4 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein AATF-Che1 PF13339.6 EEA28575.1 - 0.41 11.3 8.0 0.81 10.4 0.0 3.3 3 0 0 3 3 3 0 Apoptosis antagonizing transcription factor FapA PF03961.13 EEA28575.1 - 0.78 8.3 7.3 1.3 7.5 7.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF5094 PF17015.5 EEA28575.1 - 1.8 8.6 9.5 0.52 10.4 6.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) DUF87 PF01935.17 EEA28575.1 - 2.8 8.0 11.2 0.9 9.6 0.1 3.1 2 1 0 2 2 2 0 Helicase HerA, central domain PUL PF08324.11 EEA28576.1 - 2.1e-63 214.1 0.0 2.8e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EEA28576.1 - 4e-39 133.9 0.0 6.4e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 EEA28576.1 - 5e-15 55.4 0.0 1e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EEA28576.1 - 5.9e-05 23.0 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EEA28576.1 - 0.0014 18.6 0.0 0.0075 16.3 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_2 PF13098.6 EEA28576.1 - 0.0032 17.9 0.8 0.022 15.2 0.8 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EEA28576.1 - 0.13 11.6 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family OST_P2 PF18235.1 EEA28576.1 - 0.14 12.1 0.0 3.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Oligosaccharyltransferase Peripheral 2 domain Beta-lactamase PF00144.24 EEA28577.1 - 0.025 13.8 0.1 0.035 13.4 0.1 1.2 1 0 0 1 1 1 0 Beta-lactamase UCH PF00443.29 EEA28578.1 - 1.6e-32 113.0 0.0 3e-32 112.1 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA28578.1 - 8.2e-06 25.6 0.5 3e-05 23.8 0.5 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pik1 PF11522.8 EEA28578.1 - 0.034 14.1 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 Yeast phosphatidylinositol-4-OH kinase Pik1 Alb1 PF09135.11 EEA28579.1 - 1.3e-22 80.6 8.8 1.3e-22 80.6 8.8 1.9 1 1 1 2 2 2 1 Alb1 F-protein PF00469.20 EEA28579.1 - 0.26 10.9 4.4 0.39 10.3 4.4 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Vps16_N PF04841.13 EEA28580.1 - 3e-96 322.7 0.0 6.7e-96 321.6 0.0 1.5 2 0 0 2 2 2 1 Vps16, N-terminal region Vps16_C PF04840.12 EEA28580.1 - 2.3e-83 279.9 0.0 3.2e-83 279.4 0.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 EEA28580.1 - 0.0008 19.7 0.0 1.3 9.3 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain AAA_lid_2 PF17863.1 EEA28581.1 - 3.2e-06 26.9 0.1 5.7e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 AAA lid domain FHA PF00498.26 EEA28582.1 - 7.2e-14 51.9 0.0 1.4e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EEA28582.1 - 2.3e-10 40.0 4.2 4.8e-10 39.0 4.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EEA28582.1 - 1e-06 29.0 8.8 2.1e-06 28.0 8.8 1.6 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 EEA28582.1 - 8e-05 22.9 0.0 0.00036 20.8 0.0 2.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.6 EEA28582.1 - 0.001 19.0 6.5 0.002 18.0 6.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING-like PF08746.11 EEA28582.1 - 0.014 15.7 5.5 0.033 14.5 5.5 1.7 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.25 EEA28582.1 - 0.019 14.8 7.8 0.04 13.8 7.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA28582.1 - 0.019 15.0 2.5 0.049 13.7 2.5 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EEA28582.1 - 0.027 14.3 8.9 0.055 13.3 8.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA28582.1 - 0.094 13.0 8.4 0.32 11.3 8.4 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain PHD PF00628.29 EEA28582.1 - 0.38 10.7 5.6 0.83 9.6 5.6 1.5 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 EEA28582.1 - 1.1 9.0 8.0 2.4 7.9 8.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EEA28582.1 - 2.1 8.6 6.7 3.8 7.8 6.0 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-H2C2_2 PF13465.6 EEA28582.1 - 9.4 6.9 6.5 0.68 10.5 0.4 2.4 3 0 0 3 3 2 0 Zinc-finger double domain Arm PF00514.23 EEA28583.1 - 2.8e-78 255.8 30.7 1e-12 47.6 0.1 11.3 11 1 1 12 12 12 10 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EEA28583.1 - 1.4e-19 70.2 11.1 1e-06 29.0 0.0 7.4 4 2 4 8 8 8 4 HEAT repeats HEAT_EZ PF13513.6 EEA28583.1 - 6.7e-19 68.0 13.0 0.024 15.1 0.5 8.7 8 1 1 9 9 9 5 HEAT-like repeat HEAT PF02985.22 EEA28583.1 - 2.1e-17 61.7 14.7 0.0063 16.7 0.1 9.7 10 0 0 10 10 10 4 HEAT repeat Adaptin_N PF01602.20 EEA28583.1 - 3.7e-16 58.8 15.4 2.3e-10 39.7 6.9 3.0 2 1 1 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.13 EEA28583.1 - 5.3e-14 52.3 3.9 3e-09 36.7 1.8 2.4 1 1 1 2 2 2 2 Armadillo-like KAP PF05804.12 EEA28583.1 - 3.3e-12 45.4 0.4 9.4e-12 43.9 0.1 1.7 1 1 1 2 2 2 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 EEA28583.1 - 9.8e-10 38.2 2.8 0.0019 17.6 0.1 3.9 2 1 1 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 EEA28583.1 - 4.1e-06 26.9 9.5 0.004 17.2 0.4 5.0 1 1 4 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EEA28583.1 - 8.1e-06 25.9 7.1 0.048 13.6 0.0 4.5 2 1 1 4 4 4 2 Domain of unknown function (DUF3361) DUF5578 PF17741.1 EEA28583.1 - 9.9e-06 25.2 9.1 0.09 12.2 0.1 5.2 2 1 4 6 6 6 2 Family of unknown function (DUF5578) V-ATPase_H_C PF11698.8 EEA28583.1 - 1.2e-05 25.3 3.4 1.8 8.7 0.0 5.4 2 1 5 7 7 7 2 V-ATPase subunit H Atx10homo_assoc PF09759.9 EEA28583.1 - 0.00025 21.0 7.2 4.2 7.4 0.1 5.3 4 3 1 5 5 5 2 Spinocerebellar ataxia type 10 protein domain IFRD PF05004.13 EEA28583.1 - 0.0022 17.2 8.5 0.23 10.5 0.2 4.8 2 1 2 5 5 5 1 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 EEA28583.1 - 0.0042 17.7 0.1 1.1 9.8 0.1 3.3 1 1 2 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_PBS PF03130.16 EEA28583.1 - 0.0048 17.4 8.9 6.6 7.7 0.4 7.0 7 0 0 7 7 6 1 PBS lyase HEAT-like repeat UNC45-central PF11701.8 EEA28583.1 - 0.028 14.4 3.5 3 7.8 0.2 4.0 3 1 1 4 4 4 0 Myosin-binding striated muscle assembly central RTP1_C1 PF10363.9 EEA28583.1 - 0.041 14.1 5.5 36 4.6 0.0 5.2 3 1 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Sdh5 PF03937.16 EEA28583.1 - 0.12 12.3 1.4 11 6.1 0.1 3.6 3 2 1 4 4 4 0 Flavinator of succinate dehydrogenase IBB PF01749.20 EEA28583.1 - 0.13 12.7 2.3 1e+02 3.4 0.0 4.4 4 0 0 4 4 4 0 Importin beta binding domain YqfD PF06898.11 EEA28583.1 - 0.17 10.7 0.0 0.32 9.8 0.0 1.4 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Vpu PF00558.19 EEA28583.1 - 0.35 10.7 4.6 0.21 11.4 0.5 2.6 3 0 0 3 3 3 0 Vpu protein EXOSC1 PF10447.9 EEA28584.1 - 7.4e-24 84.5 4.9 7.4e-24 84.5 4.9 1.9 2 1 0 2 2 2 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EEA28584.1 - 1.3e-10 40.9 0.3 3.1e-10 39.7 0.3 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region V-ATPase_H_N PF03224.14 EEA28584.1 - 0.08 12.2 0.1 0.1 11.9 0.1 1.1 1 0 0 1 1 1 0 V-ATPase subunit H GTP_EFTU PF00009.27 EEA28585.1 - 4.5e-59 199.3 0.0 9.2e-59 198.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EEA28585.1 - 1.3e-15 57.2 0.0 3.1e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EEA28585.1 - 5.2e-07 29.7 0.0 1.2e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EEA28585.1 - 1.2e-06 28.8 0.0 8.1e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 EEA28585.1 - 0.00088 19.1 0.1 0.0042 16.9 0.0 2.2 3 0 0 3 3 3 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EEA28585.1 - 0.068 13.3 0.0 0.24 11.5 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase SET PF00856.28 EEA28585.1 - 0.082 13.3 1.4 4.3 7.7 0.1 2.9 3 0 0 3 3 3 0 SET domain GreA_GreB_N PF03449.15 EEA28585.1 - 0.46 10.7 12.5 5 7.4 4.8 3.0 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal D123 PF07065.14 EEA28585.1 - 9.6 5.2 10.1 0.052 12.7 1.1 1.7 2 0 0 2 2 2 0 D123 Tho2 PF11262.8 EEA28585.1 - 9.7 5.3 6.9 17 4.5 0.4 2.3 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF4604 PF15377.6 EEA28586.1 - 1.3e-23 84.3 22.2 1.5e-23 84.1 22.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Lin-8 PF03353.15 EEA28586.1 - 1.2 8.6 11.2 1.4 8.4 11.2 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 EEA28586.1 - 2 6.6 17.1 2.1 6.6 17.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EEA28586.1 - 6.2 4.9 20.9 6.8 4.8 20.9 1.0 1 0 0 1 1 1 0 Nop14-like family Prp19 PF08606.11 EEA28587.1 - 1.1e-32 111.8 1.1 2.2e-32 110.8 1.1 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EEA28587.1 - 2.4e-12 47.0 0.0 3.6e-07 30.4 0.0 4.4 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA28587.1 - 1.7e-07 31.8 1.3 0.043 14.7 0.0 5.6 6 0 0 6 6 5 1 WD domain, G-beta repeat eIF2A PF08662.11 EEA28587.1 - 9.2e-05 22.4 0.0 0.094 12.6 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A zf-RING_5 PF14634.6 EEA28587.1 - 0.0046 16.9 4.1 0.0073 16.2 4.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 EEA28587.1 - 0.0052 16.6 0.2 0.13 12.1 0.0 2.9 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit V_ATPase_I_N PF18670.1 EEA28587.1 - 0.015 15.7 0.1 0.04 14.3 0.1 1.6 1 0 0 1 1 1 0 V-type ATPase subunit I, N-terminal domain Ge1_WD40 PF16529.5 EEA28587.1 - 0.016 14.2 1.1 0.14 11.1 0.1 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-RING_UBOX PF13445.6 EEA28587.1 - 0.024 14.7 0.7 0.054 13.5 0.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Frtz PF11768.8 EEA28587.1 - 0.044 12.1 0.0 0.11 10.7 0.0 1.6 1 1 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EEA28587.1 - 0.053 12.8 0.0 2 7.7 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain zf-C3HC4_2 PF13923.6 EEA28587.1 - 0.076 12.9 0.5 0.19 11.6 0.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cytochrom_D1 PF02239.16 EEA28587.1 - 0.077 11.5 0.0 0.17 10.4 0.0 1.5 1 1 0 1 1 1 0 Cytochrome D1 heme domain zf-RING_2 PF13639.6 EEA28587.1 - 0.1 12.9 1.5 0.21 12.0 1.5 1.5 1 0 0 1 1 1 0 Ring finger domain HPS3_N PF14761.6 EEA28587.1 - 0.21 11.1 0.0 1.2 8.6 0.0 2.1 1 1 1 2 2 2 0 Hermansky-Pudlak syndrome 3 zf-C3HC4_3 PF13920.6 EEA28587.1 - 0.4 10.6 2.5 0.96 9.4 2.5 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EEA28587.1 - 0.49 10.6 2.9 0.98 9.6 2.9 1.4 1 0 0 1 1 1 0 FYVE zinc finger zf-C3HC4_4 PF15227.6 EEA28587.1 - 0.68 10.1 2.2 0.47 10.6 0.2 1.8 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EEA28587.1 - 1.2 9.1 3.7 3.8 7.5 3.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 EEA28587.1 - 1.4 9.2 4.9 9.3 6.6 1.1 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain L51_S25_CI-B8 PF05047.16 EEA28588.1 - 4.6e-15 55.3 0.1 9e-15 54.3 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain U1snRNP70_N PF12220.8 EEA28589.1 - 1.2e-27 96.3 0.4 2.8e-27 95.2 0.4 1.6 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EEA28589.1 - 4.9e-17 61.5 0.0 1.1e-16 60.4 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA28589.1 - 2.8e-05 24.1 0.0 4.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Auts2 PF15336.6 EEA28589.1 - 0.025 14.7 8.2 0.048 13.8 8.2 1.6 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein RL10P_insert PF17777.1 EEA28590.1 - 8.2e-23 80.2 0.0 1.4e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EEA28590.1 - 1.5e-18 66.8 0.0 3.3e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 MDM10 PF12519.8 EEA28591.1 - 6.9e-148 493.4 3.4 1.1e-127 426.7 1.7 2.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 TIM PF00121.18 EEA28592.1 - 6.7e-89 297.4 0.0 7.6e-89 297.3 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase MFS_1 PF07690.16 EEA28594.1 - 7.2e-36 123.8 24.6 1.1e-35 123.2 24.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28594.1 - 1.1e-09 37.8 3.2 1.1e-09 37.8 3.2 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter Pro_isomerase PF00160.21 EEA28595.1 - 2.9e-42 144.6 0.0 5.3e-42 143.8 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 EEA28595.1 - 9.5e-06 25.2 1.0 5.9e-05 22.6 1.0 2.3 1 1 0 1 1 1 1 Rtf2 RING-finger U-box PF04564.15 EEA28595.1 - 0.00011 22.3 0.1 0.0024 18.0 0.0 2.9 2 1 1 3 3 3 1 U-box domain zf-NOSIP PF15906.5 EEA28595.1 - 0.0012 19.0 0.0 0.0035 17.4 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein YjeF_N PF03853.15 EEA28596.1 - 1.5e-39 135.6 0.2 2.5e-39 134.9 0.2 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EEA28596.1 - 3.5e-07 31.0 2.6 3.5e-07 31.0 2.6 2.3 3 0 0 3 3 3 1 FDF domain PIF1 PF05970.14 EEA28597.1 - 4.1e-66 223.6 0.3 1.1e-50 172.9 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EEA28597.1 - 2e-24 86.4 0.0 3.4e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA28597.1 - 7.8e-13 49.0 0.0 8.1e-12 45.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA28597.1 - 1.2e-07 32.1 0.0 5.5e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EEA28597.1 - 2.4e-05 23.9 0.0 5.4e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region UvrD_C_2 PF13538.6 EEA28597.1 - 7e-05 22.6 0.2 0.00023 20.9 0.0 2.0 2 0 0 2 2 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 EEA28597.1 - 0.00011 22.6 0.0 0.00026 21.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Viral_helicase1 PF01443.18 EEA28597.1 - 0.00064 19.5 0.0 0.27 10.9 0.0 2.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EEA28597.1 - 0.00065 18.9 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.22 EEA28597.1 - 0.0014 19.0 0.0 0.0058 17.0 0.0 2.2 1 1 0 1 1 1 1 RNA helicase Herpes_Helicase PF02689.14 EEA28597.1 - 0.0034 15.4 0.0 0.0077 14.2 0.0 1.5 2 0 0 2 2 2 1 Helicase NB-ARC PF00931.22 EEA28597.1 - 0.0057 15.9 0.0 0.01 15.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain DUF2075 PF09848.9 EEA28597.1 - 0.0058 15.9 0.0 0.013 14.8 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 EEA28597.1 - 0.0073 16.7 0.1 0.022 15.2 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EEA28597.1 - 0.0075 16.3 0.1 0.031 14.3 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit SH3_13 PF18335.1 EEA28597.1 - 0.014 15.2 0.1 0.059 13.2 0.1 2.0 2 0 0 2 2 1 0 ATP-dependent RecD-like DNA helicase SH3 domain ATPase_2 PF01637.18 EEA28597.1 - 0.017 15.0 0.3 0.058 13.3 0.3 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea PhoH PF02562.16 EEA28597.1 - 0.018 14.5 0.0 0.072 12.5 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein TrwB_AAD_bind PF10412.9 EEA28597.1 - 0.024 13.6 0.0 0.048 12.6 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.12 EEA28597.1 - 0.032 14.2 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EEA28597.1 - 0.036 14.1 0.0 0.22 11.5 0.0 2.3 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EEA28597.1 - 0.037 13.9 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase UvrD-helicase PF00580.21 EEA28597.1 - 0.063 12.8 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_5 PF07728.14 EEA28597.1 - 0.074 13.0 0.8 0.65 10.0 0.5 2.5 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 EEA28597.1 - 0.1 12.4 1.2 0.53 10.0 0.0 2.7 3 1 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EEA28597.1 - 0.12 12.4 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase PTCB-BRCT PF12738.7 EEA28598.1 - 5.1e-52 173.7 1.1 6e-23 80.6 0.1 4.5 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 EEA28598.1 - 1.9e-31 108.3 0.1 4e-12 46.3 0.0 4.6 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EEA28598.1 - 1.5e-12 47.7 0.0 0.00033 21.0 0.0 4.9 5 0 0 5 5 5 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EEA28598.1 - 5.8e-07 29.7 0.5 0.014 15.6 0.0 4.1 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EEA28598.1 - 0.00023 21.2 0.0 5.6 7.1 0.0 3.8 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain MFS_1 PF07690.16 EEA28599.1 - 1.6e-10 40.4 12.1 2e-10 40.1 12.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Dynamin_N PF00350.23 EEA28600.1 - 2.1e-17 63.7 0.0 7.1e-17 62.0 0.0 2.0 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EEA28600.1 - 1e-10 41.7 0.0 5.3e-09 36.2 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA28600.1 - 4.9e-05 23.0 3.4 0.00026 20.6 1.1 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain TsaE PF02367.17 EEA28600.1 - 0.081 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EEA28600.1 - 0.11 13.0 0.0 0.4 11.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EEA28600.1 - 0.12 12.0 0.0 0.55 9.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_29 PF13555.6 EEA28600.1 - 0.14 11.9 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 EEA28600.1 - 0.15 11.6 0.3 39 3.7 0.0 3.2 3 0 0 3 3 3 0 Ferrous iron transport protein B Spc7 PF08317.11 EEA28600.1 - 1.9 7.3 5.4 2.9 6.7 0.3 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Snf7 PF03357.21 EEA28601.1 - 5.6e-36 123.7 19.0 1.3e-35 122.5 17.9 1.8 2 0 0 2 2 2 1 Snf7 YlqD PF11068.8 EEA28601.1 - 1.9 8.9 17.9 20 5.5 5.9 2.1 1 1 1 2 2 2 0 YlqD protein PP2C PF00481.21 EEA28602.1 - 4.1e-61 206.8 0.1 1.9e-49 168.6 0.1 3.1 2 1 1 3 3 3 3 Protein phosphatase 2C Mhr1 PF12829.7 EEA28603.1 - 1.4e-29 102.0 0.5 3.5e-29 100.7 0.2 1.9 2 0 0 2 2 2 1 Transcriptional regulation of mitochondrial recombination DUF3435 PF11917.8 EEA28603.1 - 3.8e-05 22.8 2.3 5.4e-05 22.3 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) NAD_binding_10 PF13460.6 EEA28604.1 - 2.6e-34 118.7 0.0 2.9e-34 118.6 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA28604.1 - 9.2e-09 35.2 0.1 1.5e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EEA28604.1 - 2.6e-08 33.6 0.0 3.7e-08 33.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EEA28604.1 - 0.0084 15.2 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EEA28604.1 - 0.015 14.7 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase T_hemolysin PF12261.8 EEA28604.1 - 0.018 14.8 0.1 0.025 14.3 0.1 1.1 1 0 0 1 1 1 0 Thermostable hemolysin TrkA_N PF02254.18 EEA28604.1 - 0.053 13.8 0.0 0.12 12.6 0.0 1.7 1 1 0 1 1 1 0 TrkA-N domain Fungal_trans PF04082.18 EEA28605.1 - 1.1e-16 60.7 4.9 2.2e-16 59.7 4.9 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Atg14 PF10186.9 EEA28605.1 - 2.6e-13 49.8 7.2 2.6e-13 49.8 7.2 2.7 2 1 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Zn_clus PF00172.18 EEA28605.1 - 1.3e-08 34.8 12.6 1.3e-08 34.8 12.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VPS38 PF17649.1 EEA28605.1 - 0.0081 15.1 2.7 1.3 7.8 0.0 3.2 3 0 0 3 3 3 2 Vacuolar protein sorting 38 Sigma70_ner PF04546.13 EEA28605.1 - 0.046 13.6 2.1 0.11 12.3 2.1 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2161 PF09929.9 EEA28605.1 - 0.16 12.1 0.4 0.36 11.0 0.4 1.5 1 0 0 1 1 1 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) Zn_clus PF00172.18 EEA28606.1 - 5.3e-07 29.6 14.8 8.4e-07 29.0 14.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EEA28607.1 - 2.1e-06 27.5 4.0 6.4e-06 26.0 0.5 2.7 3 0 0 3 3 3 1 F-box-like L_protein_N PF15518.6 EEA28607.1 - 0.16 11.8 0.2 0.76 9.7 0.0 2.1 2 0 0 2 2 2 0 L protein N-terminus PalH PF08733.10 EEA28608.1 - 5.7e-114 380.6 0.0 6.9e-114 380.3 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 TIP120 PF08623.10 EEA28610.1 - 3e-64 215.8 0.0 4.2e-63 212.1 0.0 2.9 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 EEA28610.1 - 1.4e-12 46.8 12.3 0.23 11.8 0.1 11.3 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.6 EEA28610.1 - 1.3e-06 28.7 16.2 0.5 10.8 0.1 9.3 7 3 3 10 10 10 2 HEAT repeats RTP1_C1 PF10363.9 EEA28610.1 - 0.0024 18.0 2.0 0.83 9.9 0.0 4.8 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EEA28610.1 - 0.003 18.0 18.2 18 5.9 0.0 10.3 12 0 0 12 12 11 0 HEAT-like repeat DRIM PF07539.12 EEA28610.1 - 0.017 13.5 4.5 0.54 8.5 0.1 4.2 4 1 0 4 4 4 0 Down-regulated in metastasis Cnd1 PF12717.7 EEA28610.1 - 0.018 15.1 0.0 1.1 9.3 0.0 3.8 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3295 PF11702.8 EEA28610.1 - 0.026 13.9 0.1 0.14 11.5 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) Head-tail_con PF12236.8 EEA28610.1 - 0.04 12.4 0.1 2 6.7 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage head to tail connecting protein UNC45-central PF11701.8 EEA28610.1 - 0.061 13.3 0.3 37 4.2 0.0 4.1 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central IFRD PF05004.13 EEA28610.1 - 0.081 12.0 1.0 0.24 10.4 0.1 2.4 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TAF6_C PF07571.13 EEA28610.1 - 0.082 13.2 0.0 1.2 9.5 0.0 3.2 2 1 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain TRAM_LAG1_CLN8 PF03798.16 EEA28613.1 - 2.3e-39 135.2 21.4 3.9e-39 134.4 21.4 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EEA28613.1 - 5.8e-23 80.3 0.4 1.9e-22 78.7 0.0 2.1 2 0 0 2 2 2 1 TRAM1-like protein DNA_pol_phi PF04931.13 EEA28613.1 - 0.19 9.8 3.9 0.26 9.3 3.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 EEA28613.1 - 8 6.2 8.6 14 5.4 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TRAM_LAG1_CLN8 PF03798.16 EEA28614.1 - 1.1e-39 136.3 21.4 1.7e-39 135.6 21.4 1.3 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EEA28614.1 - 5e-17 61.3 0.3 5e-17 61.3 0.3 2.3 3 0 0 3 3 3 1 TRAM1-like protein DNA_pol_phi PF04931.13 EEA28614.1 - 0.11 10.6 3.7 0.14 10.2 3.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 EEA28614.1 - 5.7 6.6 8.7 8.9 6.0 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Glyco_hydro_127 PF07944.12 EEA28615.1 - 3.4e-19 68.7 0.0 7.8e-17 61.0 0.0 2.1 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 DUF5011 PF16403.5 EEA28615.1 - 0.074 13.2 1.6 0.17 12.0 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5011) Transglut_core PF01841.19 EEA28616.1 - 2.7e-12 47.1 0.0 5.6e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 EEA28616.1 - 0.047 13.2 0.0 0.17 11.4 0.0 1.8 2 1 0 2 2 2 0 Transglutaminase-like domain Ras PF00071.22 EEA28617.1 - 1.5e-30 105.9 0.1 2.1e-30 105.5 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA28617.1 - 2.4e-23 82.6 0.1 4.8e-23 81.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA28617.1 - 1.7e-06 27.6 0.1 2.3e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA28617.1 - 0.00014 21.3 0.1 0.00018 20.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 EEA28617.1 - 0.0079 15.1 0.1 1.2 7.9 0.0 2.1 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) CAF1C_H4-bd PF12265.8 EEA28618.1 - 9e-16 57.9 0.0 4.8e-15 55.6 0.0 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EEA28618.1 - 3.2e-12 46.7 6.6 5.3e-06 27.1 0.1 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28618.1 - 6.3e-08 32.8 0.4 0.00049 20.3 0.1 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA28618.1 - 0.03 13.0 1.7 0.59 8.7 0.2 2.1 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Fungal_trans PF04082.18 EEA28619.1 - 1.6e-23 83.1 0.5 3e-23 82.2 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EEA28619.1 - 6.2e-07 29.6 6.3 6.2e-07 29.6 6.3 3.0 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EEA28619.1 - 2.5e-06 27.6 19.2 0.0012 19.2 3.1 3.5 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA28619.1 - 0.0058 17.4 18.4 0.1 13.5 1.6 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger T3SS_needle_E PF08988.10 EEA28619.1 - 0.038 14.1 0.0 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle zf-C2H2_jaz PF12171.8 EEA28619.1 - 0.46 10.8 3.5 3.1 8.2 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EEA28619.1 - 1.4 8.8 8.7 12 5.7 1.8 3.0 2 0 0 2 2 2 0 zinc-finger C2H2-type Utp8 PF10395.9 EEA28620.1 - 1e-13 50.8 0.0 2.2e-11 43.0 0.1 3.1 2 1 0 2 2 2 2 Utp8 family AAA PF00004.29 EEA28621.1 - 3.6e-08 33.9 0.1 3.6e-07 30.7 0.1 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EEA28621.1 - 2.6e-06 27.5 0.2 0.0026 17.7 0.0 3.7 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 EEA28621.1 - 0.0012 19.3 0.0 0.0034 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EEA28621.1 - 0.01 15.0 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 EEA28621.1 - 0.036 14.3 0.1 0.37 11.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EEA28621.1 - 0.043 14.3 0.0 0.17 12.4 0.0 2.0 1 0 0 1 1 1 0 ABC transporter SAM_2 PF07647.17 EEA28622.1 - 2.1e-14 53.4 0.0 3.1e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EEA28622.1 - 5.5e-13 49.4 0.0 1e-12 48.5 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 EEA28622.1 - 2.3e-12 47.1 0.0 3.6e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 EEA28622.1 - 0.0093 15.9 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Nha1_C PF08619.10 EEA28623.1 - 2.3e-117 393.1 43.8 3.4e-117 392.5 43.8 1.2 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EEA28623.1 - 7.2e-77 258.7 18.3 8.7e-77 258.5 18.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CstA PF02554.14 EEA28623.1 - 0.0053 15.7 1.3 0.0053 15.7 1.3 1.9 2 0 0 2 2 2 1 Carbon starvation protein CstA YrhC PF14143.6 EEA28623.1 - 0.29 11.2 3.9 0.22 11.6 1.1 2.2 2 0 0 2 2 2 0 YrhC-like protein DUF21 PF01595.20 EEA28623.1 - 0.56 9.9 7.5 0.062 13.0 1.7 2.3 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain PRP4 PF08799.11 EEA28623.1 - 2.8 7.6 5.1 1.6 8.3 0.2 2.6 2 0 0 2 2 2 0 pre-mRNA processing factor 4 (PRP4) like PX PF00787.24 EEA28624.1 - 1.1e-17 64.1 0.2 2.1e-17 63.1 0.2 1.5 1 0 0 1 1 1 1 PX domain TonB_N PF16031.5 EEA28624.1 - 0.0084 16.6 12.2 0.018 15.6 12.2 1.6 1 0 0 1 1 1 1 TonB polyproline region Prefoldin_3 PF13758.6 EEA28624.1 - 0.056 13.5 1.7 0.1 12.7 0.1 2.2 2 0 0 2 2 2 0 Prefoldin subunit Trypan_PARP PF05887.11 EEA28624.1 - 0.15 12.0 8.8 0.33 10.9 8.8 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2868 PF11067.8 EEA28624.1 - 0.28 10.7 2.4 0.48 9.9 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) SOG2 PF10428.9 EEA28624.1 - 3.8 6.6 5.9 6.6 5.8 5.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein EnY2 PF10163.9 EEA28625.1 - 0.0077 16.6 0.0 0.022 15.1 0.0 1.8 1 1 0 1 1 1 1 Transcription factor e(y)2 AAA PF00004.29 EEA28626.1 - 2.4e-97 322.4 0.0 2e-47 160.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA28626.1 - 8.3e-24 83.1 5.8 6.7e-13 48.2 1.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EEA28626.1 - 1.8e-18 66.5 1.7 4.1e-18 65.3 0.7 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EEA28626.1 - 2.6e-14 53.7 0.0 1.6e-07 31.6 0.0 3.2 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EEA28626.1 - 7.1e-14 51.9 0.0 1.3e-05 25.0 0.0 3.0 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA28626.1 - 2.6e-12 47.5 0.0 0.00013 22.4 0.0 4.5 3 2 1 4 4 3 2 AAA ATPase domain AAA_33 PF13671.6 EEA28626.1 - 3.7e-12 46.6 0.0 2.4e-05 24.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EEA28626.1 - 3.3e-11 43.3 0.3 3.1e-05 24.0 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EEA28626.1 - 1.9e-09 37.2 0.1 0.0014 17.9 0.0 2.8 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EEA28626.1 - 3.8e-09 36.9 0.5 0.029 14.7 0.0 4.2 2 2 1 3 3 3 2 AAA domain CDC48_2 PF02933.17 EEA28626.1 - 1.4e-08 34.4 0.2 4.3e-08 32.8 0.0 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 Mg_chelatase PF01078.21 EEA28626.1 - 7e-08 32.1 0.2 0.0062 16.0 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EEA28626.1 - 6.2e-07 30.0 0.0 0.021 15.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EEA28626.1 - 6.4e-07 29.5 0.0 0.016 15.2 0.0 2.9 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 EEA28626.1 - 8.6e-07 29.3 0.0 0.041 14.3 0.0 2.9 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 EEA28626.1 - 9.6e-07 28.7 0.0 0.035 13.8 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase PF06745.13 EEA28626.1 - 1.4e-06 27.9 0.1 0.52 9.6 0.0 3.4 3 0 0 3 3 3 2 KaiC AAA_7 PF12775.7 EEA28626.1 - 1.9e-06 27.5 0.0 0.02 14.4 0.0 3.3 3 1 0 3 3 3 2 P-loop containing dynein motor region Vps4_C PF09336.10 EEA28626.1 - 2.8e-06 27.2 0.1 2.1e-05 24.4 0.0 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_24 PF13479.6 EEA28626.1 - 7e-06 25.9 0.0 0.13 11.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.6 EEA28626.1 - 7.3e-06 25.7 4.5 0.34 10.5 0.1 4.9 3 2 2 5 5 5 1 AAA domain DUF815 PF05673.13 EEA28626.1 - 1.1e-05 24.7 0.0 0.006 15.8 0.0 2.8 3 0 0 3 3 2 1 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EEA28626.1 - 1.2e-05 24.5 0.1 0.043 12.9 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 EEA28626.1 - 1.4e-05 25.4 0.1 0.19 12.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 EEA28626.1 - 4.8e-05 23.1 0.0 0.56 9.9 0.0 3.2 2 2 0 2 2 2 2 Sigma-54 interaction domain Bac_DnaA PF00308.18 EEA28626.1 - 5e-05 23.2 0.0 0.17 11.7 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein ABC_tran PF00005.27 EEA28626.1 - 7.5e-05 23.3 0.0 0.22 12.0 0.0 3.4 2 1 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 EEA28626.1 - 0.00013 22.4 0.0 0.59 10.5 0.0 3.1 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 EEA28626.1 - 0.00017 21.6 0.0 0.36 10.9 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EEA28626.1 - 0.00024 21.2 0.0 0.084 12.9 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EEA28626.1 - 0.0003 20.3 0.3 0.78 9.1 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_11 PF13086.6 EEA28626.1 - 0.00031 20.6 0.0 1.1 9.0 0.0 2.6 3 0 0 3 3 2 2 AAA domain AAA_3 PF07726.11 EEA28626.1 - 0.00032 20.6 0.0 1.1 9.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EEA28626.1 - 0.00052 20.0 0.0 2.7 7.8 0.0 3.6 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EEA28626.1 - 0.00069 19.6 0.1 0.41 10.6 0.0 2.9 3 0 0 3 3 3 1 NACHT domain DUF2075 PF09848.9 EEA28626.1 - 0.0015 17.9 0.0 1.5 7.9 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EEA28626.1 - 0.0015 18.3 0.4 1.4 8.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EEA28626.1 - 0.004 16.9 0.0 0.34 10.6 0.0 2.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 EEA28626.1 - 0.0059 15.8 0.0 1.2 8.3 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain AAA_19 PF13245.6 EEA28626.1 - 0.0063 16.9 1.1 6.1 7.2 0.0 3.5 3 1 0 4 4 2 0 AAA domain IPT PF01745.16 EEA28626.1 - 0.009 15.4 0.0 2.4 7.5 0.0 2.3 2 0 0 2 2 2 1 Isopentenyl transferase NTPase_1 PF03266.15 EEA28626.1 - 0.01 15.8 0.6 2.2 8.2 0.0 3.8 4 0 0 4 4 3 1 NTPase Zeta_toxin PF06414.12 EEA28626.1 - 0.013 14.8 0.0 6.1 6.1 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin UFD1 PF03152.14 EEA28626.1 - 0.019 14.5 0.0 0.15 11.6 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 KAP_NTPase PF07693.14 EEA28626.1 - 0.023 13.9 0.4 1.1 8.4 0.0 3.0 2 2 1 4 4 4 0 KAP family P-loop domain Sigma54_activ_2 PF14532.6 EEA28626.1 - 0.024 14.7 0.0 4.1 7.5 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 EEA28626.1 - 0.028 14.2 0.0 5.7 6.6 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase Zot PF05707.12 EEA28626.1 - 0.059 13.0 0.0 2.5 7.7 0.0 3.0 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AFG1_ATPase PF03969.16 EEA28626.1 - 0.076 11.9 0.0 11 4.8 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase AAA_6 PF12774.7 EEA28626.1 - 0.16 10.9 0.1 9 5.1 0.0 2.3 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region E1-E2_ATPase PF00122.20 EEA28627.1 - 7.3e-49 165.7 0.7 4.2e-48 163.3 0.3 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EEA28627.1 - 9e-33 114.3 0.1 1.7e-32 113.5 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EEA28627.1 - 5.4e-28 97.2 0.0 2.9e-12 46.8 0.0 3.5 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EEA28627.1 - 6.3e-08 32.7 0.9 1.8e-05 24.6 0.4 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA28627.1 - 5.9e-05 23.5 0.0 0.00063 20.2 0.0 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase DAHP_snth_FXD PF18152.1 EEA28627.1 - 0.058 13.2 0.2 9.2 6.2 0.0 3.2 3 0 0 3 3 3 0 DAHP synthase ferredoxin-like domain DIT1_PvcA PF05141.12 EEA28628.1 - 6.9e-80 268.5 0.0 9e-80 268.1 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein POTRA PF07244.15 EEA28628.1 - 0.0073 16.9 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 Surface antigen variable number repeat MFS_1 PF07690.16 EEA28629.1 - 3.5e-26 92.0 51.9 1.2e-25 90.2 36.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DJ-1_PfpI PF01965.24 EEA28630.1 - 1.7e-06 27.9 0.0 7e-06 25.9 0.0 2.2 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EEA28630.1 - 0.011 15.4 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like GATase_5 PF13507.6 EEA28630.1 - 0.13 11.4 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DIT1_PvcA PF05141.12 EEA28631.1 - 8.9e-87 291.1 0.0 1.2e-86 290.6 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Amidase PF01425.21 EEA28631.1 - 9.6e-34 117.1 1.1 1.7e-33 116.3 0.2 1.8 3 0 0 3 3 3 1 Amidase PEX11 PF05648.14 EEA28632.1 - 3e-13 49.8 0.5 3.8e-12 46.1 0.1 2.0 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) GST_N_4 PF17172.4 EEA28632.1 - 0.066 14.0 0.1 0.16 12.7 0.1 1.7 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Mpv17_PMP22 PF04117.12 EEA28633.1 - 1.4e-12 47.7 1.9 8.8e-12 45.1 1.2 2.2 1 1 1 2 2 2 1 Mpv17 / PMP22 family Cullin_binding PF03556.15 EEA28634.1 - 5.7e-31 107.5 1.3 5.7e-31 107.5 1.3 1.5 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 EEA28634.1 - 1.8e-13 50.0 0.4 7.1e-13 48.2 0.3 2.0 2 0 0 2 2 2 1 UBA-like domain CRAL_TRIO_N PF03765.15 EEA28634.1 - 0.0031 17.7 0.0 0.0071 16.5 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain ChW PF07538.11 EEA28634.1 - 0.0056 16.6 0.2 2.3 8.2 0.0 2.8 2 0 0 2 2 2 2 Clostridial hydrophobic W TAP_C PF03943.13 EEA28634.1 - 0.035 13.8 0.1 0.077 12.7 0.1 1.6 1 0 0 1 1 1 0 TAP C-terminal domain CUE PF02845.16 EEA28634.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 CUE domain UPF0113_N PF17833.1 EEA28635.1 - 1.9e-26 92.4 0.1 2.7e-26 92.0 0.1 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EEA28635.1 - 1.9e-22 79.3 0.0 3.8e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EEA28635.1 - 0.0092 15.9 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 PUA domain PP1 PF07430.11 EEA28635.1 - 0.058 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain NOC3p PF07540.11 EEA28636.1 - 1.7e-30 105.3 0.2 6.4e-30 103.5 0.2 2.1 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 EEA28636.1 - 8.9e-24 84.4 0.0 8.9e-24 84.4 0.0 2.4 2 1 0 2 2 2 1 CBF/Mak21 family DUF4611 PF15387.6 EEA28636.1 - 0.0038 17.4 2.7 0.0038 17.4 2.7 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4611) DUF1349 PF07081.11 EEA28638.1 - 3.2e-17 62.8 0.0 4.6e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) MRP-L46 PF11788.8 EEA28639.1 - 7.6e-39 133.1 0.3 1.4e-38 132.3 0.3 1.5 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 EEA28639.1 - 0.0003 20.8 0.0 0.00064 19.8 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain CAF1 PF04857.20 EEA28640.1 - 5.6e-78 262.3 0.0 6.7e-78 262.1 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease CAF1 PF04857.20 EEA28641.1 - 5.6e-78 262.3 0.0 6.7e-78 262.1 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease Pex26 PF07163.12 EEA28642.1 - 0.082 12.2 4.8 0.18 11.1 2.3 2.2 2 0 0 2 2 2 0 Pex26 protein LTV PF04180.14 EEA28642.1 - 0.096 12.4 10.7 0.15 11.8 10.7 1.2 1 0 0 1 1 1 0 Low temperature viability protein DUF572 PF04502.13 EEA28642.1 - 0.79 9.3 15.3 1.3 8.5 15.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Hid1 PF12722.7 EEA28642.1 - 0.96 7.5 5.6 1.4 7.0 5.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 EEA28642.1 - 1.1 8.2 5.7 2 7.4 5.7 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S64 PF08192.11 EEA28642.1 - 1.5 7.2 7.2 3 6.2 7.2 1.5 1 0 0 1 1 1 0 Peptidase family S64 Presenilin PF01080.17 EEA28642.1 - 3.2 6.4 6.5 5 5.8 6.5 1.3 1 0 0 1 1 1 0 Presenilin SBF_like PF13593.6 EEA28643.1 - 1.3e-96 323.7 17.9 1.5e-96 323.5 17.9 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Mem_trans PF03547.18 EEA28643.1 - 0.0043 15.5 0.1 0.0043 15.5 0.1 2.9 2 2 0 2 2 2 1 Membrane transport protein Mito_carr PF00153.27 EEA28644.1 - 4.2e-65 215.7 1.0 2.9e-22 78.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Sacchrp_dh_NADP PF03435.18 EEA28645.1 - 1.7e-19 70.3 0.0 3.3e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EEA28645.1 - 0.059 13.8 0.0 0.2 12.1 0.0 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EEA28646.1 - 2.5e-11 44.0 0.0 5.2e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Abhydrolase_1 PF00561.20 EEA28647.1 - 2.5e-18 66.7 0.3 2.6e-14 53.5 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA28647.1 - 6.8e-15 56.3 0.0 9.3e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA28647.1 - 1.2e-12 47.6 0.0 3.6e-11 42.8 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF3530 PF12048.8 EEA28647.1 - 0.0018 17.7 0.0 0.0027 17.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) Abhydrolase_4 PF08386.10 EEA28647.1 - 0.012 15.7 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Pinin_SDK_memA PF04696.13 EEA28648.1 - 5.4e-30 104.1 18.2 5.4e-30 104.1 18.2 3.3 2 1 1 4 4 4 1 pinin/SDK/memA/ protein conserved region DUF1682 PF07946.14 EEA28648.1 - 4.7 6.3 24.3 0.78 8.9 5.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) PHF5 PF03660.14 EEA28649.1 - 7e-53 177.2 9.9 7.8e-53 177.1 9.9 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EEA28649.1 - 0.11 10.3 4.9 0.12 10.3 4.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EEA28649.1 - 1.1 9.3 15.2 2.5 8.2 1.4 3.0 1 1 1 2 2 2 0 Double zinc ribbon Cofilin_ADF PF00241.20 EEA28650.1 - 1.6e-28 99.0 0.0 2.1e-17 63.1 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein NMT1 PF09084.11 EEA28651.1 - 2.1e-76 256.7 0.0 2.9e-76 256.2 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like ASFV_360 PF01671.16 EEA28651.1 - 0.11 12.0 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 African swine fever virus multigene family 360 protein NMT1_2 PF13379.6 EEA28651.1 - 0.16 11.7 0.1 8 6.1 0.0 2.9 3 1 1 4 4 4 0 NMT1-like family NMT1 PF09084.11 EEA28652.1 - 7.5e-55 186.2 0.0 1.1e-54 185.7 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like PHD PF00628.29 EEA28653.1 - 2e-09 37.2 5.1 2e-09 37.2 5.1 2.5 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 EEA28653.1 - 1.5e-08 34.8 1.3 1.5e-08 34.8 1.3 3.3 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EEA28653.1 - 6.9e-08 32.7 0.4 6.9e-08 32.7 0.4 2.7 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EEA28653.1 - 2.1e-06 27.5 2.4 2.1e-06 27.5 2.4 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.6 EEA28653.1 - 8.4e-06 25.2 1.5 8.4e-06 25.2 1.5 1.8 2 0 0 2 2 2 1 PHD-finger zf-C3HC4 PF00097.25 EEA28653.1 - 2.1e-05 24.3 0.3 2.1e-05 24.3 0.3 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA28653.1 - 2.3e-05 24.2 0.7 2.3e-05 24.2 0.7 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EEA28653.1 - 0.00011 22.0 0.2 0.00011 22.0 0.2 2.7 4 0 0 4 4 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA28653.1 - 0.00094 19.0 1.0 0.00094 19.0 1.0 3.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA28653.1 - 0.0018 18.3 0.2 0.0018 18.3 0.2 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EEA28653.1 - 0.0046 16.7 1.5 0.041 13.6 0.1 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EEA28653.1 - 0.0082 16.1 1.1 0.0082 16.1 1.1 2.6 2 1 0 2 2 2 1 RING-type zinc-finger DZR PF12773.7 EEA28653.1 - 0.013 15.5 4.5 0.14 12.2 0.7 3.0 1 1 2 3 3 3 0 Double zinc ribbon zf-Di19 PF05605.12 EEA28653.1 - 0.02 15.2 1.4 11 6.4 0.9 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn_ribbon_17 PF17120.5 EEA28653.1 - 0.028 14.0 0.7 0.028 14.0 0.7 2.3 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zinc_ribbon_2 PF13240.6 EEA28653.1 - 0.16 11.7 1.7 4.4 7.1 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain FYVE_2 PF02318.16 EEA28653.1 - 0.23 11.7 0.9 19 5.5 0.1 2.7 1 1 1 2 2 2 0 FYVE-type zinc finger Prok-RING_1 PF14446.6 EEA28653.1 - 1.1 9.2 8.0 0.9 9.5 2.2 2.8 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 EEA28653.1 - 1.4 8.5 6.2 0.3 10.7 0.3 2.5 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain zf-RING-like PF08746.11 EEA28653.1 - 1.6 9.1 8.3 0.85 10.0 1.6 2.6 2 0 0 2 2 2 0 RING-like domain Prim_Zn_Ribbon PF08273.12 EEA28653.1 - 6.1 7.2 7.3 17 5.8 0.8 3.2 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase GPI2 PF06432.11 EEA28654.1 - 0.013 14.9 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Tim17 PF02466.19 EEA28654.1 - 0.06 13.7 2.8 3.7 8.0 2.8 2.2 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family RRM_1 PF00076.22 EEA28655.1 - 2.3e-13 49.7 1.3 2.9e-13 49.4 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hamartin PF04388.12 EEA28655.1 - 3.7 6.1 16.0 4.8 5.7 16.0 1.1 1 0 0 1 1 1 0 Hamartin protein Com_YlbF PF06133.11 EEA28656.1 - 0.041 14.5 0.4 0.083 13.5 0.4 1.4 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA PNP_UDP_1 PF01048.20 EEA28657.1 - 1.2e-14 54.1 0.2 1.9e-13 50.2 0.2 2.2 1 1 0 1 1 1 1 Phosphorylase superfamily ABC_tran PF00005.27 EEA28659.1 - 6.2e-27 94.8 0.0 1.6e-19 70.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA28659.1 - 1.8e-14 54.1 23.7 1.4e-08 34.8 6.2 3.3 2 1 1 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 EEA28659.1 - 2.1e-07 30.6 0.1 0.0002 20.8 0.0 3.2 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA28659.1 - 7.9e-06 25.5 0.2 0.21 11.4 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA28659.1 - 0.0015 18.8 0.1 1.1 9.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA28659.1 - 0.0032 18.0 0.0 3.3 8.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EEA28659.1 - 0.0034 17.8 0.4 1.4 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 EEA28659.1 - 0.0055 16.5 0.1 2.3 7.9 0.1 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EEA28659.1 - 0.0094 15.8 2.5 1.8 8.3 0.0 3.3 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA28659.1 - 0.011 15.7 0.4 3.5 7.5 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase DUF87 PF01935.17 EEA28659.1 - 0.014 15.5 0.2 0.058 13.5 0.0 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_33 PF13671.6 EEA28659.1 - 0.017 15.3 1.5 3.7 7.7 0.1 3.0 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 EEA28659.1 - 0.064 13.0 1.4 1.6 8.5 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein PRK PF00485.18 EEA28659.1 - 0.09 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Dynamin_N PF00350.23 EEA28659.1 - 0.11 12.6 0.1 3.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family Mg_chelatase PF01078.21 EEA28659.1 - 0.15 11.4 0.1 2.4 7.5 0.0 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 EEA28659.1 - 0.15 12.5 0.2 32 5.0 0.0 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EEA28659.1 - 0.16 12.0 0.2 30 4.7 0.0 3.0 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EEA28659.1 - 0.25 11.8 0.4 7.7 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain MFS_1 PF07690.16 EEA28660.1 - 3e-52 177.7 29.8 2e-46 158.5 20.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EEA28660.1 - 2.3e-07 29.6 4.7 2.3e-07 29.6 4.7 2.6 4 0 0 4 4 4 1 Transmembrane secretion effector OATP PF03137.20 EEA28660.1 - 0.0038 15.6 15.7 0.0055 15.0 2.3 3.6 3 1 1 4 4 4 2 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 EEA28660.1 - 0.089 12.1 20.8 0.11 11.7 2.7 3.2 2 1 1 3 3 3 0 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 EEA28660.1 - 0.5 9.2 28.9 0.074 11.9 1.1 3.9 2 2 1 3 3 3 0 Sugar (and other) transporter Sec2p PF06428.11 EEA28661.1 - 3.1e-10 39.9 8.7 3.1e-10 39.9 8.7 2.4 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Tektin PF03148.14 EEA28661.1 - 0.00011 21.1 0.6 0.00011 21.1 0.6 2.1 2 0 0 2 2 2 1 Tektin family Cluap1 PF10234.9 EEA28661.1 - 0.0016 17.9 1.9 0.0016 17.9 1.9 2.1 2 0 0 2 2 2 1 Clusterin-associated protein-1 PAT1 PF09770.9 EEA28661.1 - 0.017 13.4 14.7 0.02 13.2 14.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4795 PF16043.5 EEA28661.1 - 0.021 14.4 7.8 0.23 11.0 0.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) zf-ribbon_3 PF13248.6 EEA28661.1 - 0.061 12.8 0.3 0.097 12.1 0.3 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Exonuc_VII_L PF02601.15 EEA28661.1 - 0.14 11.7 16.5 0.24 10.9 7.0 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit TFIIA PF03153.13 EEA28661.1 - 0.14 12.1 17.7 0.19 11.7 17.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GOLGA2L5 PF15070.6 EEA28661.1 - 0.23 10.1 17.1 0.014 14.1 5.3 2.1 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Nsp1_C PF05064.13 EEA28661.1 - 0.36 10.7 11.9 0.23 11.3 2.0 2.9 2 1 1 3 3 3 0 Nsp1-like C-terminal region Jnk-SapK_ap_N PF09744.9 EEA28661.1 - 0.8 9.9 22.1 0.15 12.3 7.9 2.3 3 0 0 3 3 2 0 JNK_SAPK-associated protein-1 MCC-bdg_PDZ PF10506.9 EEA28661.1 - 0.8 9.8 9.6 1.2 9.2 2.2 3.1 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome FAM76 PF16046.5 EEA28661.1 - 0.89 8.9 10.4 0.44 9.9 7.4 1.7 1 1 1 2 2 2 0 FAM76 protein TMPIT PF07851.13 EEA28661.1 - 1.4 8.1 11.2 2 7.6 1.8 2.1 2 0 0 2 2 2 0 TMPIT-like protein Laminin_II PF06009.12 EEA28661.1 - 1.5 8.8 13.0 4.4 7.3 4.7 2.2 2 0 0 2 2 2 0 Laminin Domain II DUF16 PF01519.16 EEA28661.1 - 2 9.0 8.6 3.3 8.2 0.9 2.5 3 0 0 3 3 2 0 Protein of unknown function DUF16 DUF724 PF05266.14 EEA28661.1 - 2.6 7.8 11.4 4.4 7.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Atg14 PF10186.9 EEA28661.1 - 4.3 6.3 14.5 1.3 8.1 1.1 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3584 PF12128.8 EEA28661.1 - 5.1 4.5 20.7 0.97 6.9 6.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) COG2 PF06148.11 EEA28661.1 - 6.4 6.9 9.3 6.8 6.8 3.6 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Heme_oxygenase PF01126.20 EEA28662.1 - 9.8e-11 41.8 0.0 2.9e-10 40.3 0.0 1.9 1 1 0 1 1 1 1 Heme oxygenase cwf18 PF08315.12 EEA28662.1 - 0.0043 17.7 0.0 0.0095 16.6 0.0 1.5 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor MFS_1 PF07690.16 EEA28663.1 - 3.5e-40 138.0 40.3 3.5e-40 138.0 40.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28663.1 - 3.2e-09 36.2 9.1 3.2e-09 36.2 9.1 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter Fmp27 PF10344.9 EEA28664.1 - 4.3e-226 753.1 0.0 8e-226 752.2 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial protein from FMP27 Apt1 PF10351.9 EEA28664.1 - 8.4e-194 644.9 0.2 8.4e-194 644.9 0.2 3.8 4 0 0 4 4 4 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 EEA28664.1 - 5.1e-171 569.8 4.9 5.1e-171 569.8 4.9 1.8 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 EEA28664.1 - 1.5e-56 190.8 0.1 1e-55 188.1 0.0 2.3 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EEA28664.1 - 6e-54 182.2 0.1 1.4e-53 181.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EEA28664.1 - 4e-31 107.8 0.0 9.3e-30 103.4 0.0 3.3 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Glyco_tranf_2_3 PF13641.6 EEA28666.1 - 2.4e-21 76.7 0.0 3.7e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EEA28666.1 - 1.4e-19 70.8 0.1 1.4e-19 70.8 0.1 2.8 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EEA28666.1 - 1.8e-16 60.4 0.0 2.8e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EEA28666.1 - 1.4e-07 31.2 0.0 3.4e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EEA28666.1 - 6.5e-06 25.8 0.0 1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Cellulose_synt PF03552.14 EEA28666.1 - 1.5 7.2 3.4 5.9 5.3 0.0 2.4 2 1 1 3 3 3 0 Cellulose synthase DUF4939 PF16297.5 EEA28667.1 - 1.2e-05 25.1 0.0 2.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.17 EEA28667.1 - 0.00047 20.4 2.6 0.00057 20.1 0.1 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein T3SSipB PF16535.5 EEA28667.1 - 0.002 18.6 3.0 0.25 11.8 1.6 2.5 2 0 0 2 2 2 1 Type III cell invasion protein SipB DUF1759 PF03564.15 EEA28667.1 - 0.0051 16.8 0.9 0.0051 16.8 0.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) FlgN PF05130.12 EEA28667.1 - 0.0091 16.5 6.6 0.3 11.6 0.1 2.8 3 0 0 3 3 3 2 FlgN protein TPR_MLP1_2 PF07926.12 EEA28667.1 - 0.012 15.7 9.2 0.031 14.3 4.4 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Goodbye PF17109.5 EEA28667.1 - 0.03 14.8 0.3 2.8 8.4 0.1 2.4 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain Fez1 PF06818.15 EEA28667.1 - 0.045 14.2 4.5 0.035 14.6 1.9 1.9 2 0 0 2 2 2 0 Fez1 CK2S PF15011.6 EEA28667.1 - 0.27 11.1 5.6 5.1 6.9 1.6 2.8 2 1 1 3 3 3 0 Casein Kinase 2 substrate DUF2408 PF10303.9 EEA28667.1 - 0.33 11.5 5.7 0.22 12.1 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) APG6_N PF17675.1 EEA28667.1 - 0.38 11.3 7.5 1.6 9.3 1.9 2.6 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF573 PF04504.14 EEA28667.1 - 0.47 11.1 3.5 2.9 8.6 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function, DUF573 MCU PF04678.13 EEA28667.1 - 0.61 10.2 7.1 3.5 7.7 0.1 2.4 1 1 1 2 2 2 0 Mitochondrial calcium uniporter DUF1043 PF06295.12 EEA28667.1 - 0.76 9.8 6.2 7.7 6.5 1.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF948 PF06103.11 EEA28667.1 - 0.85 9.9 3.6 2.6 8.4 3.6 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF3450 PF11932.8 EEA28667.1 - 1.2 8.4 9.4 1.2 8.4 5.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Mer2 PF09074.10 EEA28667.1 - 1.4 8.7 10.8 6.3 6.6 0.1 3.0 2 1 1 3 3 3 0 Mer2 SlyX PF04102.12 EEA28667.1 - 2.3 8.9 13.0 0.83 10.3 8.9 2.4 2 1 0 2 2 1 0 SlyX Exonuc_VII_L PF02601.15 EEA28667.1 - 2.5 7.6 8.2 7.3 6.1 8.2 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 EEA28667.1 - 4.8 6.3 7.2 1.2 8.3 2.8 1.8 2 0 0 2 2 2 0 TMPIT-like protein FliD_N PF02465.18 EEA28667.1 - 5.9 7.7 11.1 2.6 8.8 1.9 3.1 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF2570 PF10828.8 EEA28667.1 - 7.1 6.5 9.0 4.2 7.2 6.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) RVT_1 PF00078.27 EEA28668.1 - 1.6e-26 93.2 0.5 4.8e-26 91.6 0.1 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 EEA28668.1 - 1.8e-20 73.2 0.2 2.2e-19 69.7 0.1 2.4 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EEA28668.1 - 2e-15 56.6 0.4 1.4e-08 34.6 0.1 2.7 2 1 1 3 3 3 2 RNase H-like domain found in reverse transcriptase Gag_p15 PF08723.10 EEA28668.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Gag protein p15 rve PF00665.26 EEA28669.1 - 1.1e-15 57.9 0.0 1.9e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EEA28669.1 - 6.5e-13 48.4 4.4 1.6e-12 47.1 4.4 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Integrase_H2C2 PF17921.1 EEA28669.1 - 0.0065 16.6 2.0 0.017 15.2 2.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RNase_H PF00075.24 EEA28670.1 - 5.1e-07 30.0 0.0 1.3e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 EEA28670.1 - 1.1e-05 26.0 0.0 2.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase HET PF06985.11 EEA28671.1 - 2.1e-07 31.4 0.0 9.1e-05 22.8 0.0 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Fungal_trans PF04082.18 EEA28672.1 - 1.9e-12 46.8 1.6 3.3e-12 46.0 1.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28672.1 - 4e-06 26.9 13.3 9.7e-06 25.6 13.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 EEA28672.1 - 4e-05 23.8 19.0 0.0012 19.2 6.5 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA28672.1 - 0.00044 20.5 2.7 0.00044 20.5 2.7 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA28672.1 - 0.012 16.4 5.1 0.012 16.4 5.1 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-Di19 PF05605.12 EEA28672.1 - 0.086 13.1 4.8 0.25 11.7 4.8 1.9 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 EEA28672.1 - 0.21 12.0 3.6 25 5.5 0.0 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA28672.1 - 0.77 10.1 13.5 1.2 9.5 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding p450 PF00067.22 EEA28673.1 - 1.2e-74 251.7 0.0 1.5e-74 251.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_4 PF07993.12 EEA28674.1 - 7.7e-32 110.5 0.0 1.2e-31 109.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EEA28674.1 - 1.8e-17 63.1 0.0 3e-14 52.5 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme Epimerase PF01370.21 EEA28674.1 - 1.6e-10 40.9 0.0 7.1e-10 38.7 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EEA28674.1 - 4.5e-09 36.5 0.1 1.9e-08 34.5 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site KR PF08659.10 EEA28674.1 - 0.00023 21.1 0.0 0.00072 19.5 0.0 1.9 1 1 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EEA28674.1 - 0.0037 16.7 0.0 0.0072 15.8 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EEA28674.1 - 0.0067 15.5 0.0 0.013 14.5 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EEA28674.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein CaiF_GrlA PF07180.11 EEA28675.1 - 0.026 14.5 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 CaiF/GrlA transcriptional regulator Glyco_hydro_88 PF07470.13 EEA28675.1 - 0.039 13.0 0.1 0.045 12.8 0.1 1.1 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 DUF373 PF04123.13 EEA28675.1 - 0.17 11.3 4.3 0.19 11.1 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) UbiA PF01040.18 EEA28677.1 - 3.9e-39 134.5 17.6 5e-39 134.1 17.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family TrbC PF04956.13 EEA28677.1 - 2.2 8.6 7.2 0.15 12.3 0.9 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family p450 PF00067.22 EEA28678.1 - 8.5e-55 186.3 0.0 1e-54 186.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Acetyltransf_3 PF13302.7 EEA28679.1 - 6.5e-23 81.9 0.0 8.1e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA28679.1 - 4.2e-07 30.2 0.0 2.3e-06 27.8 0.0 1.9 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 EEA28679.1 - 0.041 13.6 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA28679.1 - 0.062 13.3 0.0 0.7 9.9 0.0 2.3 2 0 0 2 2 2 0 FR47-like protein Cellulase PF00150.18 EEA28680.1 - 1.1e-19 71.0 0.9 1.6e-19 70.5 0.9 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) T2SSI PF02501.17 EEA28680.1 - 0.042 14.0 0.1 0.094 12.9 0.1 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I FAD_binding_3 PF01494.19 EEA28681.1 - 1.5e-21 77.1 0.2 3.9e-20 72.4 0.2 2.1 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA28681.1 - 1.7e-07 30.8 0.0 0.00029 20.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA28681.1 - 6.8e-07 29.2 0.8 1e-05 25.3 0.8 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EEA28681.1 - 2e-06 27.9 0.1 1.2e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EEA28681.1 - 4.4e-06 26.0 0.2 0.014 14.5 0.1 3.0 3 0 0 3 3 3 2 Lycopene cyclase protein FAD_binding_2 PF00890.24 EEA28681.1 - 2.5e-05 23.5 0.4 0.00011 21.4 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EEA28681.1 - 3.3e-05 22.8 0.1 0.00014 20.7 0.1 1.8 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 EEA28681.1 - 0.0013 18.0 0.2 0.0049 16.2 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EEA28681.1 - 0.0045 17.0 0.1 0.022 14.7 0.1 2.0 1 1 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 EEA28681.1 - 0.0059 15.9 1.3 0.044 13.0 0.1 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EEA28681.1 - 0.012 16.2 0.0 0.029 14.9 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EEA28681.1 - 0.021 14.4 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 EEA28681.1 - 0.033 13.1 0.1 6.4 5.5 0.1 2.3 2 0 0 2 2 2 0 Tryptophan halogenase GIDA PF01134.22 EEA28681.1 - 0.037 13.1 0.3 0.12 11.5 0.0 1.9 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EEA28681.1 - 0.047 13.0 0.1 0.16 11.3 0.2 2.0 2 1 0 2 2 2 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA28681.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amidoligase_2 PF12224.8 EEA28682.1 - 2.9e-07 30.4 0.3 0.0019 17.9 0.1 2.2 2 0 0 2 2 2 2 Putative amidoligase enzyme adh_short PF00106.25 EEA28683.1 - 1.2e-21 77.1 0.0 4.4e-19 68.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28683.1 - 1.6e-10 41.0 0.0 5.9e-10 39.1 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EEA28683.1 - 1.7e-06 27.7 0.0 2.2e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EEA28683.1 - 0.00022 21.2 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 EEA28683.1 - 0.17 12.5 0.0 0.32 11.6 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent p450 PF00067.22 EEA28684.1 - 4.5e-63 213.6 0.0 5.6e-63 213.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HypF_C PF17788.1 EEA28684.1 - 0.15 12.7 0.1 0.29 11.9 0.1 1.4 1 0 0 1 1 1 0 HypF Kae1-like domain p450 PF00067.22 EEA28685.1 - 4.8e-57 193.7 0.0 6.6e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ANTAR PF03861.14 EEA28686.1 - 0.013 15.4 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 ANTAR domain Peptidase_C14 PF00656.22 EEA28688.1 - 6.1e-50 170.5 0.0 8.3e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain UCH_1 PF13423.6 EEA28688.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase MFS_1 PF07690.16 EEA28690.1 - 2.7e-31 108.8 33.3 2.7e-31 108.8 33.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28690.1 - 2.1e-09 36.8 6.9 2.1e-09 36.8 6.9 2.3 1 1 1 2 2 2 1 Sugar (and other) transporter Fungal_trans_2 PF11951.8 EEA28691.1 - 8.5e-07 28.1 0.0 1.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28691.1 - 1.8e-06 27.9 12.0 1.8e-06 27.9 12.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TMEM223 PF14640.6 EEA28692.1 - 0.16 12.2 0.6 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Transmembrane protein 223 DUF1857 PF08982.11 EEA28693.1 - 2.5e-48 163.7 0.0 2.8e-48 163.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1857) UPF0236 PF06782.11 EEA28693.1 - 0.053 12.1 0.0 0.059 12.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) DLH PF01738.18 EEA28694.1 - 1.4e-07 31.3 0.0 2.5e-07 30.5 0.0 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_8 PF06259.12 EEA28694.1 - 0.022 14.4 0.1 0.048 13.3 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_1 PF00561.20 EEA28694.1 - 0.065 12.9 0.0 0.15 11.7 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA28694.1 - 0.12 11.6 0.0 3.4 6.9 0.0 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Glyco_hydro_18 PF00704.28 EEA28695.1 - 5.1e-10 39.6 0.0 8.1e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Fungal_trans_2 PF11951.8 EEA28695.1 - 0.002 17.0 0.0 0.0049 15.7 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain GhoS PF11080.8 EEA28695.1 - 0.06 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Endoribonuclease GhoS MIT PF04212.18 EEA28695.1 - 0.17 11.9 0.0 0.55 10.3 0.0 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Peptidase_A4 PF01828.17 EEA28697.1 - 1.6e-74 249.9 17.5 1.8e-74 249.7 17.5 1.1 1 0 0 1 1 1 1 Peptidase A4 family adh_short PF00106.25 EEA28697.1 - 0.02 14.4 0.9 0.028 13.9 0.9 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DUF1869 PF08956.10 EEA28697.1 - 0.12 12.2 1.2 0.27 11.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) Toxin_35 PF10530.9 EEA28698.1 - 0.005 16.8 1.3 0.0071 16.3 1.3 1.2 1 0 0 1 1 1 1 Toxin with inhibitor cystine knot ICK or Knottin scaffold Toxin_12 PF07740.12 EEA28698.1 - 0.02 15.6 3.4 0.03 15.0 3.4 1.3 1 0 0 1 1 1 0 Ion channel inhibitory toxin Lipase_GDSL PF00657.22 EEA28699.1 - 3.1e-12 46.9 0.0 4.6e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase UQ_con PF00179.26 EEA28700.1 - 2.5e-26 92.0 0.1 2.9e-26 91.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA28700.1 - 1.9e-05 24.4 0.0 2.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EEA28700.1 - 0.011 16.0 0.1 0.016 15.5 0.1 1.3 1 0 0 1 1 1 0 RWD domain UQ_con PF00179.26 EEA28701.1 - 5.3e-25 87.7 0.2 6.4e-25 87.4 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA28701.1 - 1.7e-05 24.5 0.0 2.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EEA28701.1 - 0.018 15.3 0.1 0.025 14.9 0.1 1.4 1 0 0 1 1 1 0 RWD domain Complex1_49kDa PF00346.19 EEA28702.1 - 9.9e-125 415.1 0.0 1.4e-124 414.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EEA28702.1 - 0.0084 15.1 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Nickel-dependent hydrogenase DUF2990 PF11693.8 EEA28702.1 - 0.12 12.5 0.1 24 5.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2990) RNA_pol_A_bac PF01000.26 EEA28703.1 - 5.9e-27 94.3 0.0 1.2e-26 93.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EEA28703.1 - 3.9e-19 67.8 0.0 5.4e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain ThiF PF00899.21 EEA28704.1 - 8.6e-67 225.0 0.0 1.3e-66 224.5 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EEA28704.1 - 2.5e-30 104.5 0.1 4.2e-30 103.7 0.1 1.4 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 EEA28704.1 - 0.00026 21.1 0.4 0.00077 19.5 0.0 1.9 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase E1_UFD PF09358.10 EEA28704.1 - 0.0045 17.7 0.0 0.011 16.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain Sacchrp_dh_NADP PF03435.18 EEA28704.1 - 0.032 14.5 0.2 0.61 10.4 0.1 2.9 4 0 0 4 4 4 0 Saccharopine dehydrogenase NADP binding domain Ecm33 PF12454.8 EEA28704.1 - 0.06 13.5 0.6 0.13 12.4 0.6 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein UDPG_MGDP_dh_N PF03721.14 EEA28704.1 - 0.072 12.7 1.4 0.18 11.3 0.0 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 EEA28704.1 - 0.081 13.5 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PglD_N PF17836.1 EEA28704.1 - 0.16 12.6 1.6 0.33 11.6 0.5 2.0 1 1 0 2 2 2 0 PglD N-terminal domain DUF3419 PF11899.8 EEA28704.1 - 0.2 10.8 0.0 0.37 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) UBA_e1_thiolCys PF10585.9 EEA28704.1 - 0.31 10.9 2.9 7.7 6.4 0.0 2.3 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site ThiF PF00899.21 EEA28705.1 - 1e-45 156.0 0.0 1.4e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EEA28705.1 - 1.9e-30 104.9 0.1 3e-30 104.2 0.1 1.4 1 0 0 1 1 1 1 E2 binding domain E1_UFD PF09358.10 EEA28705.1 - 0.0031 18.2 0.0 0.0079 16.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain Ecm33 PF12454.8 EEA28705.1 - 0.049 13.8 0.6 0.1 12.8 0.6 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein UBA_e1_thiolCys PF10585.9 EEA28705.1 - 0.2 11.6 3.1 4 7.3 0.1 2.3 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site Telomere_reg-2 PF10193.9 EEA28706.1 - 2.6e-30 105.1 0.0 2.5e-29 101.9 0.0 2.5 2 0 0 2 2 2 1 Telomere length regulation protein TPP_enzyme_N PF02776.18 EEA28708.1 - 3e-38 131.1 0.0 1.6e-37 128.7 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EEA28708.1 - 7.2e-17 61.6 0.0 1.5e-16 60.6 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA28708.1 - 3.2e-10 39.9 0.0 1.7e-09 37.5 0.0 2.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain Aminotran_1_2 PF00155.21 EEA28709.1 - 1.3e-15 57.5 0.0 1.5e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EEA28709.1 - 0.024 13.4 0.0 0.049 12.4 0.0 1.4 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase Pro-kuma_activ PF09286.11 EEA28710.1 - 3.6e-46 157.0 0.1 1.3e-45 155.2 0.1 1.8 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EEA28710.1 - 1.6e-05 24.4 1.7 2.7e-05 23.6 1.7 1.3 1 0 0 1 1 1 1 Subtilase family ACC_epsilon PF13822.6 EEA28710.1 - 0.018 15.7 1.1 0.035 14.8 1.1 1.4 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit Pkinase PF00069.25 EEA28711.1 - 1.9e-54 184.8 0.0 2.6e-54 184.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28711.1 - 5.7e-39 134.0 0.0 8.4e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA28711.1 - 2.3e-06 27.1 0.0 3.8e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA28711.1 - 0.00011 21.1 0.0 0.00028 19.8 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EEA28711.1 - 0.0039 17.2 0.0 0.0075 16.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA28711.1 - 0.012 15.0 0.0 0.029 13.7 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EEA28711.1 - 0.045 12.7 0.1 0.29 10.0 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain FTA2 PF13095.6 EEA28711.1 - 0.16 11.5 0.0 0.52 9.9 0.0 1.7 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF4368 PF14287.6 EEA28711.1 - 0.2 12.0 0.1 0.6 10.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) YrbL-PhoP_reg PF10707.9 EEA28711.1 - 0.2 11.1 0.1 5.8 6.4 0.0 2.8 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL F-box-like PF12937.7 EEA28713.1 - 0.043 13.7 0.9 0.043 13.7 0.9 2.3 3 0 0 3 3 3 0 F-box-like BCDHK_Adom3 PF10436.9 EEA28714.1 - 8.8e-46 155.7 0.0 1.2e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EEA28714.1 - 9e-12 45.5 0.0 5.3e-11 43.0 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EEA28714.1 - 0.088 12.8 0.5 0.9 9.5 0.5 2.2 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain DUF1989 PF09347.10 EEA28716.1 - 3.6e-21 75.5 0.0 4.6e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) RIBIOP_C PF04950.12 EEA28717.1 - 1.6e-96 323.1 0.0 3.9e-96 321.9 0.0 1.6 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EEA28717.1 - 1.5e-28 98.7 0.0 5.5e-28 96.9 0.0 2.1 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.6 EEA28717.1 - 2.6e-05 24.5 0.3 8.4e-05 22.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain GTP_EFTU PF00009.27 EEA28717.1 - 9.5e-05 22.0 0.0 0.013 15.1 0.0 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EEA28717.1 - 0.0002 21.8 0.0 0.00062 20.2 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EEA28717.1 - 0.00066 19.8 1.5 0.001 19.2 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 EEA28717.1 - 0.00068 20.1 0.0 0.0017 18.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EEA28717.1 - 0.0026 17.8 0.7 0.0097 16.0 0.1 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase TsaE PF02367.17 EEA28717.1 - 0.0031 17.5 0.0 0.021 14.8 0.0 2.1 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EEA28717.1 - 0.0051 16.0 0.0 0.0092 15.2 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_18 PF13238.6 EEA28717.1 - 0.0054 17.3 2.7 0.051 14.1 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EEA28717.1 - 0.0096 16.3 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EEA28717.1 - 0.01 15.8 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EEA28717.1 - 0.013 15.0 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EEA28717.1 - 0.017 14.8 0.0 0.2 11.4 0.0 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EEA28717.1 - 0.02 15.4 0.0 0.02 15.4 0.0 2.6 3 0 0 3 3 2 0 ABC transporter RNA_helicase PF00910.22 EEA28717.1 - 0.021 15.2 0.0 0.051 14.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 EEA28717.1 - 0.027 14.4 0.0 0.085 12.8 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea cobW PF02492.19 EEA28717.1 - 0.03 13.9 0.1 0.06 12.9 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EEA28717.1 - 0.038 13.9 0.0 0.16 11.9 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase NTPase_1 PF03266.15 EEA28717.1 - 0.041 13.8 0.2 0.078 12.9 0.2 1.4 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.6 EEA28717.1 - 0.058 13.4 0.1 0.22 11.6 0.1 2.0 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EEA28717.1 - 0.062 13.3 0.0 0.23 11.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 EEA28717.1 - 0.081 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain MobB PF03205.14 EEA28717.1 - 0.087 12.7 0.1 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Roc PF08477.13 EEA28717.1 - 0.099 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 EEA28717.1 - 0.17 11.7 0.1 0.65 9.9 0.0 1.9 2 0 0 2 2 2 0 Rad17 P-loop domain ATP_bind_1 PF03029.17 EEA28717.1 - 0.18 11.6 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_11 PF13086.6 EEA28717.1 - 0.19 11.5 0.0 0.19 11.5 0.0 3.3 4 0 0 4 4 3 0 AAA domain Whi5 PF08528.11 EEA28718.1 - 0.13 11.9 0.3 0.27 10.9 0.3 1.5 1 0 0 1 1 1 0 Whi5 like Zn_clus PF00172.18 EEA28719.1 - 1.8e-05 24.7 8.1 3.1e-05 24.0 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyoxalase PF00903.25 EEA28720.1 - 3.3e-12 46.7 0.0 6.6e-12 45.7 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EEA28720.1 - 0.00055 20.2 0.0 0.0008 19.7 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TxDE PF18711.1 EEA28720.1 - 0.16 12.1 0.0 0.84 9.8 0.0 2.1 1 1 0 1 1 1 0 Toxoflavin-degrading enzyme PWI PF01480.17 EEA28721.1 - 1.8e-09 37.8 0.2 3.4e-09 36.9 0.2 1.4 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 EEA28721.1 - 1.4e-07 31.2 0.3 5.4e-06 26.1 0.1 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA28721.1 - 3.2e-07 30.2 0.0 7.5e-05 22.7 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.24 EEA28721.1 - 0.00026 20.8 1.7 0.00055 19.8 1.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EEA28721.1 - 0.031 14.1 1.7 0.053 13.3 1.7 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger RRM_5 PF13893.6 EEA28721.1 - 0.092 12.4 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 EEA28721.1 - 0.13 12.1 0.0 0.55 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Torus PF16131.5 EEA28721.1 - 0.36 11.6 0.1 0.36 11.6 0.1 2.1 2 0 0 2 2 2 0 Torus domain UPF0242 PF06785.11 EEA28721.1 - 2 8.5 8.7 3.5 7.7 8.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GTP_EFTU PF00009.27 EEA28722.1 - 7.7e-67 224.6 0.3 1.1e-66 224.1 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EEA28722.1 - 4.5e-33 113.6 0.0 1.1e-32 112.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EEA28722.1 - 3.5e-22 78.3 0.0 8.3e-22 77.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EEA28722.1 - 1.8e-13 50.4 0.0 4.7e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EEA28722.1 - 2.3e-13 50.3 0.1 1.3e-12 47.9 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA28722.1 - 0.00015 21.8 0.1 0.00033 20.7 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Solute_trans_a PF03619.16 EEA28724.1 - 4.1e-99 331.4 11.1 4.9e-99 331.2 11.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Dynactin PF12455.8 EEA28726.1 - 2.5e-94 315.7 12.5 2.5e-94 315.7 12.5 4.0 3 1 0 3 3 3 2 Dynein associated protein CAP_GLY PF01302.25 EEA28726.1 - 1.5e-22 79.4 0.2 2.6e-22 78.6 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF2353 PF09789.9 EEA28726.1 - 0.025 14.0 79.2 0.0064 15.9 10.8 4.0 3 1 1 4 4 4 0 Uncharacterized coiled-coil protein (DUF2353) Abi_C PF14355.6 EEA28726.1 - 0.57 10.3 3.2 17 5.6 0.1 4.0 4 0 0 4 4 4 0 Abortive infection C-terminus DUF3452 PF11934.8 EEA28726.1 - 0.81 9.2 3.8 0.8 9.3 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3452) HAD_2 PF13419.6 EEA28727.1 - 7e-08 32.8 0.0 1.1e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA28727.1 - 8.7e-08 32.7 0.0 3.6e-07 30.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA28728.1 - 4.1e-07 30.5 0.0 5.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA28728.1 - 1.2e-05 25.5 0.0 1.7e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase KH_1 PF00013.29 EEA28730.1 - 1e-31 108.6 0.7 9.4e-07 28.6 0.1 7.2 7 0 0 7 7 7 4 KH domain SUV3_C PF12513.8 EEA28730.1 - 0.18 11.7 0.0 0.54 10.2 0.0 1.9 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal Chitin_synth_2 PF03142.15 EEA28731.1 - 9.3e-246 816.5 1.9 1.3e-245 816.0 1.9 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 EEA28731.1 - 1.1e-67 228.7 0.0 9.2e-67 225.7 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 EEA28731.1 - 9.5e-20 70.5 0.2 2.6e-15 56.3 0.0 3.6 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 EEA28731.1 - 2.2e-15 56.3 0.1 9.9e-15 54.2 0.2 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 EEA28731.1 - 7.6e-11 42.3 0.0 5.8e-10 39.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EEA28731.1 - 5.8e-10 39.4 1.9 1.5e-09 38.1 1.9 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EEA28731.1 - 0.0011 18.8 0.0 0.53 10.1 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 AAA_16 PF13191.6 EEA28731.1 - 0.03 14.7 1.3 0.49 10.7 0.1 2.9 3 0 0 3 3 3 0 AAA ATPase domain Chitin_synth_2 PF03142.15 EEA28732.1 - 1.6e-227 756.3 0.0 2.3e-227 755.8 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase DEK_C PF08766.11 EEA28732.1 - 4.2e-17 61.8 2.7 1.1e-16 60.4 1.3 2.4 3 0 0 3 3 3 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EEA28732.1 - 1.7e-13 50.9 4.7 3.4e-13 50.0 2.7 2.4 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.28 EEA28732.1 - 4.2e-13 49.2 0.1 6.2e-06 26.3 0.0 3.0 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Myosin_head PF00063.21 EEA28732.1 - 7.7e-12 44.3 0.0 3.9e-11 41.9 0.0 1.8 1 1 0 1 1 1 1 Myosin head (motor domain) Glyco_tranf_2_3 PF13641.6 EEA28732.1 - 1.7e-11 44.5 0.0 4.6e-11 43.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EEA28732.1 - 0.0029 17.1 0.1 0.022 14.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EEA28732.1 - 0.012 15.5 0.0 0.46 10.3 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 GCN5L1 PF06320.13 EEA28733.1 - 1e-22 80.5 3.7 1.8e-22 79.6 3.7 1.4 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) MRP-S26 PF14943.6 EEA28733.1 - 0.14 12.1 1.3 0.16 11.9 0.2 1.6 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 MutL_C PF08676.11 EEA28734.1 - 1.6e-21 76.6 0.0 4.7e-21 75.1 0.0 1.9 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EEA28734.1 - 3.4e-19 68.7 0.0 3.5e-18 65.4 0.0 2.5 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EEA28734.1 - 3.6e-12 46.3 0.0 1.5e-11 44.3 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EEA28734.1 - 1.3e-07 32.1 0.3 7.8e-07 29.6 0.1 2.5 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Serinc PF03348.15 EEA28735.1 - 5.5e-162 539.6 12.2 6.3e-162 539.4 12.2 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) YtpI PF14007.6 EEA28735.1 - 0.6 10.3 14.1 0.54 10.4 3.2 3.2 3 0 0 3 3 3 0 YtpI-like protein T2SSF PF00482.23 EEA28735.1 - 1.4 8.9 0.0 1.4 8.9 0.0 4.5 5 1 0 5 5 5 0 Type II secretion system (T2SS), protein F Nodulin-like PF06813.13 EEA28736.1 - 1.8e-23 83.3 2.5 4.2e-23 82.1 2.5 1.6 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 EEA28736.1 - 4.3e-13 48.9 34.8 1.1e-12 47.6 26.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EEA28737.1 - 1.1e-23 84.0 2.5 2.9e-23 82.7 2.5 1.7 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 EEA28737.1 - 2e-15 56.6 35.7 2.3e-15 56.4 27.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GATA PF00320.27 EEA28738.1 - 1.5e-15 56.5 2.6 2.6e-15 55.7 2.6 1.4 1 0 0 1 1 1 1 GATA zinc finger Pox_A_type_inc PF04508.12 EEA28738.1 - 5.9e-05 22.7 3.8 0.015 15.2 1.2 3.2 3 0 0 3 3 3 2 Viral A-type inclusion protein repeat TF_Zn_Ribbon PF08271.12 EEA28738.1 - 0.013 15.0 0.6 0.024 14.2 0.6 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding DUF4618 PF15397.6 EEA28738.1 - 0.039 13.4 0.8 0.057 12.8 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) DivIVA PF05103.13 EEA28738.1 - 0.052 13.6 3.1 2.3 8.3 3.1 2.1 1 1 0 1 1 1 0 DivIVA protein HSBP1 PF06825.12 EEA28738.1 - 0.07 13.0 0.4 0.16 11.9 0.4 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 GST_C_5 PF16865.5 EEA28738.1 - 0.12 13.0 0.0 0.2 12.3 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ArfGap PF01412.18 EEA28738.1 - 0.13 12.3 0.4 0.26 11.4 0.1 1.6 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf CENP-F_leu_zip PF10473.9 EEA28738.1 - 0.37 10.8 6.5 4.8 7.2 0.1 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JIP_LZII PF16471.5 EEA28738.1 - 2.2 8.5 6.2 5 7.4 2.1 2.3 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II PI3_PI4_kinase PF00454.27 EEA28739.1 - 1.5e-45 156.0 0.0 2.1e-45 155.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase HET PF06985.11 EEA28740.1 - 5.8e-20 72.1 0.0 9.8e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SNF2_N PF00176.23 EEA28741.1 - 3.9e-60 203.4 0.2 5.8e-60 202.9 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA28741.1 - 1.1e-10 41.8 0.0 1.9e-09 37.9 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA28741.1 - 5.8e-05 22.9 0.0 0.00013 21.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase HIRAN PF08797.11 EEA28741.1 - 0.0058 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain zf-RING_5 PF14634.6 EEA28741.1 - 0.11 12.5 2.6 0.19 11.7 2.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Med21 PF11221.8 EEA28742.1 - 1.9e-55 187.1 0.8 4e-55 186.0 0.8 1.5 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 EEA28742.1 - 0.027 14.5 2.5 0.098 12.8 2.5 2.0 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4404 PF14357.6 EEA28742.1 - 0.12 13.0 0.8 0.31 11.7 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) DUF2721 PF11026.8 EEA28742.1 - 0.32 10.9 0.8 0.53 10.2 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF1192 PF06698.11 EEA28742.1 - 3.1 7.9 6.9 5.9 7.0 6.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF2034 PF10356.9 EEA28743.1 - 8.1e-40 136.2 0.0 4.9e-25 88.0 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EEA28743.1 - 2.3e-08 34.0 0.0 3.7e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Restriction endonuclease Spc24 PF08286.11 EEA28744.1 - 4.9e-38 129.6 3.2 6e-37 126.1 0.1 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 CLZ PF16526.5 EEA28744.1 - 0.0011 19.2 7.6 0.12 12.8 1.8 2.5 2 0 0 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ING PF12998.7 EEA28744.1 - 0.017 15.7 1.8 0.082 13.5 0.1 2.2 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding WXG100 PF06013.12 EEA28744.1 - 0.026 14.7 1.6 1.8 8.8 0.1 2.6 2 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF4795 PF16043.5 EEA28744.1 - 0.032 13.9 2.1 0.066 12.8 2.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) TPR_MLP1_2 PF07926.12 EEA28744.1 - 0.035 14.2 9.7 0.46 10.6 9.9 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein YjcZ PF13990.6 EEA28744.1 - 0.038 13.4 0.4 0.06 12.7 0.4 1.3 1 0 0 1 1 1 0 YjcZ-like protein Prefoldin_2 PF01920.20 EEA28744.1 - 0.042 13.8 2.9 4.1 7.4 0.5 2.3 2 0 0 2 2 2 0 Prefoldin subunit XhlA PF10779.9 EEA28744.1 - 0.088 13.0 6.9 0.44 10.8 1.3 2.3 2 0 0 2 2 2 0 Haemolysin XhlA DUF724 PF05266.14 EEA28744.1 - 0.12 12.1 4.5 0.34 10.7 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 EEA28744.1 - 0.14 10.0 0.8 0.14 10.0 0.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAS PF13851.6 EEA28744.1 - 0.39 10.0 8.1 0.2 11.0 1.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4472 PF14739.6 EEA28744.1 - 0.61 10.8 7.3 1.5 9.5 1.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Spc7 PF08317.11 EEA28744.1 - 0.82 8.5 8.1 1.3 7.9 8.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 EEA28744.1 - 0.98 10.1 7.7 1.9 9.2 0.6 2.6 1 1 0 2 2 2 0 SlyX Wbp11 PF09429.10 EEA28744.1 - 1 9.8 5.4 1.4 9.4 3.2 2.2 1 1 1 2 2 2 0 WW domain binding protein 11 APG6_N PF17675.1 EEA28744.1 - 1.6 9.2 13.0 2.4 8.7 13.0 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region GARP PF16731.5 EEA28744.1 - 2.3 7.9 9.2 0.15 11.8 1.4 2.1 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma FlaC_arch PF05377.11 EEA28744.1 - 4.7 7.7 4.9 32 5.0 0.1 2.6 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) DUF1690 PF07956.11 EEA28744.1 - 5.9 7.3 8.5 30 5.0 8.5 1.9 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) Fis1_TPR_C PF14853.6 EEA28745.1 - 1.7e-27 95.2 1.2 2.6e-27 94.6 1.2 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EEA28745.1 - 2.2e-17 62.4 0.1 4.4e-17 61.4 0.1 1.6 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 EEA28745.1 - 0.00013 21.8 2.6 0.0003 20.7 2.6 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA28745.1 - 0.0022 18.5 0.6 0.0044 17.5 0.6 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA28745.1 - 0.013 16.1 0.1 0.03 15.0 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA28745.1 - 0.015 15.1 3.4 0.033 14.0 3.4 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA28745.1 - 0.038 14.6 0.3 0.1 13.3 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA28745.1 - 0.046 14.5 0.7 0.093 13.6 0.3 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat adh_short PF00106.25 EEA28746.1 - 5.7e-45 153.2 0.1 8.5e-45 152.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28746.1 - 5.2e-38 130.9 0.1 7.5e-38 130.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase zf-RING_2 PF13639.6 EEA28746.1 - 4.3e-13 49.4 8.5 4.3e-13 49.4 8.5 2.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 EEA28746.1 - 1.8e-10 40.4 2.3 1.8e-10 40.4 2.3 2.0 2 0 0 2 2 1 1 RING-like zinc finger KR PF08659.10 EEA28746.1 - 1.9e-10 40.9 0.2 2.9e-10 40.3 0.2 1.2 1 0 0 1 1 1 1 KR domain zf-C3HC4_2 PF13923.6 EEA28746.1 - 2.5e-09 36.8 8.6 2.5e-09 36.8 8.6 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA28746.1 - 1.4e-07 31.3 3.1 1.4e-07 31.3 3.1 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA28746.1 - 2.8e-07 30.7 7.6 1e-06 28.9 7.6 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain Epimerase PF01370.21 EEA28746.1 - 3.7e-07 29.8 0.1 7.4e-07 28.9 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family zf-C3HC4 PF00097.25 EEA28746.1 - 9.4e-06 25.4 7.4 9.4e-06 25.4 7.4 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) NmrA PF05368.13 EEA28746.1 - 9.8e-06 25.3 0.2 1.6e-05 24.6 0.2 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EEA28746.1 - 4.8e-05 23.3 0.7 7.5e-05 22.7 0.7 1.3 1 0 0 1 1 1 1 NAD(P)H-binding zf-RING_UBOX PF13445.6 EEA28746.1 - 0.00014 21.8 3.8 0.00014 21.8 3.8 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA28746.1 - 0.00034 20.5 5.2 0.00034 20.5 5.2 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zinc_ribbon_9 PF14369.6 EEA28746.1 - 0.0011 19.1 6.7 0.013 15.7 2.8 2.9 2 1 1 3 3 3 1 zinc-ribbon RmlD_sub_bind PF04321.17 EEA28746.1 - 0.0017 17.5 0.2 0.0027 16.8 0.2 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain DUF1776 PF08643.10 EEA28746.1 - 0.003 17.0 0.0 0.0044 16.4 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Prok-RING_4 PF14447.6 EEA28746.1 - 0.0057 16.5 5.4 0.0057 16.5 5.4 2.6 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EEA28746.1 - 0.0061 16.6 2.7 0.0061 16.6 2.7 1.9 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger F420_oxidored PF03807.17 EEA28746.1 - 0.017 15.7 1.0 0.065 13.8 0.1 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent HypA PF01155.19 EEA28746.1 - 0.018 15.0 5.0 0.046 13.7 0.3 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_17 PF17120.5 EEA28746.1 - 0.057 13.0 6.5 0.19 11.4 6.5 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type GDP_Man_Dehyd PF16363.5 EEA28746.1 - 0.059 12.8 0.1 0.089 12.2 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DFP PF04127.15 EEA28746.1 - 0.093 12.6 0.3 0.16 11.8 0.3 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein ADH_zinc_N PF00107.26 EEA28746.1 - 0.097 12.7 0.4 0.18 11.8 0.4 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DZR PF12773.7 EEA28746.1 - 0.11 12.5 6.2 4.7 7.3 0.2 2.6 2 0 0 2 2 2 0 Double zinc ribbon zf-FPG_IleRS PF06827.14 EEA28746.1 - 0.44 10.5 2.8 13 5.8 0.0 2.7 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zinc_ribbon_2 PF13240.6 EEA28746.1 - 0.51 10.1 2.6 11 5.9 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 EEA28746.1 - 0.54 10.3 6.3 5 7.2 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbons Rad50_zn_hook PF04423.14 EEA28746.1 - 0.68 9.8 3.4 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zinc_ribbon_4 PF13717.6 EEA28746.1 - 0.84 9.6 3.3 12 5.9 0.0 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Cys_rich_CPXG PF14255.6 EEA28746.1 - 0.97 9.4 4.8 14 5.6 0.1 3.3 3 0 0 3 3 3 0 Cysteine-rich CPXCG RINGv PF12906.7 EEA28746.1 - 1.3 9.2 8.7 3.4 7.9 8.7 1.7 1 0 0 1 1 1 0 RING-variant domain zf-ribbon_3 PF13248.6 EEA28746.1 - 1.4 8.4 5.0 39 3.8 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain FANCL_C PF11793.8 EEA28746.1 - 1.7 8.9 6.7 15 5.9 6.7 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Di19 PF05605.12 EEA28746.1 - 2.1 8.7 5.0 12 6.3 0.1 2.9 3 0 0 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING-like PF08746.11 EEA28746.1 - 3.9 7.9 12.7 0.17 12.2 5.6 2.3 2 0 0 2 2 2 0 RING-like domain PHD PF00628.29 EEA28746.1 - 8.8 6.3 14.2 1.5 8.7 6.7 2.7 2 0 0 2 2 2 0 PHD-finger GYF PF02213.16 EEA28747.1 - 1.7e-17 62.8 0.3 4e-17 61.6 0.3 1.7 1 0 0 1 1 1 1 GYF domain PI31_Prot_N PF11566.8 EEA28748.1 - 1e-47 162.0 0.1 1.3e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EEA28748.1 - 4.8e-16 59.7 18.4 4.8e-16 59.7 18.4 2.9 2 0 0 2 2 2 1 PI31 proteasome regulator DUF3747 PF12565.8 EEA28748.1 - 0.0051 16.2 0.0 0.0081 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3747) Metallophos PF00149.28 EEA28749.1 - 3.8e-38 132.1 0.4 6.5e-38 131.3 0.4 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA28749.1 - 0.027 14.9 0.1 0.058 13.9 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Fungal_trans PF04082.18 EEA28750.1 - 4.4e-17 62.0 0.5 8.1e-17 61.1 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA28750.1 - 1.5e-05 25.2 14.8 0.0013 19.1 1.4 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA28750.1 - 3.2e-05 24.4 11.1 0.041 14.7 1.2 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA28750.1 - 0.066 13.5 3.0 0.98 9.8 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding LIM PF00412.22 EEA28750.1 - 0.12 12.6 5.1 0.27 11.5 5.1 1.6 1 0 0 1 1 1 0 LIM domain zf-C2HC_2 PF13913.6 EEA28750.1 - 0.73 9.8 7.7 0.32 11.0 2.9 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type HgmA PF04209.13 EEA28751.1 - 4e-165 549.7 0.1 4.6e-165 549.4 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase COesterase PF00135.28 EEA28752.1 - 2.4e-60 204.9 0.0 1.8e-59 202.0 0.0 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA28752.1 - 0.0076 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA28752.1 - 0.01 15.1 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 AbiEii PF08843.11 EEA28752.1 - 0.057 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyl transferase AbiEii toxin, Type IV TA system COesterase PF00135.28 EEA28753.1 - 1.5e-60 205.5 0.0 1.9e-60 205.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA28753.1 - 8.6e-08 32.3 0.0 4.7e-07 29.9 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA28753.1 - 0.00048 20.8 0.3 0.00086 20.0 0.2 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EEA28753.1 - 0.048 13.1 0.0 0.077 12.5 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family TPR_12 PF13424.6 EEA28754.1 - 0.072 13.4 0.6 0.072 13.4 0.6 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2443 PF10398.9 EEA28754.1 - 0.1 12.7 0.0 0.3 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) TPR_2 PF07719.17 EEA28754.1 - 0.11 12.6 6.6 9.4 6.6 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA28754.1 - 0.24 11.3 5.0 6.6 6.7 0.2 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4407 PF14362.6 EEA28754.1 - 1.6 8.0 8.9 2.2 7.6 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) T3SSipB PF16535.5 EEA28754.1 - 3.4 8.1 11.8 0.68 10.4 6.6 2.2 2 0 0 2 2 2 0 Type III cell invasion protein SipB HAD_2 PF13419.6 EEA28755.1 - 2.6e-18 66.7 0.0 3.8e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EEA28755.1 - 2.3e-09 37.9 0.0 4.8e-08 33.5 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA28755.1 - 0.0036 17.3 0.0 0.017 15.2 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like NT5C PF06941.12 EEA28755.1 - 0.041 13.8 0.0 0.16 11.8 0.0 1.9 1 1 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) NIR_SIR PF01077.22 EEA28755.1 - 0.15 11.6 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Nitrite and sulphite reductase 4Fe-4S domain ArabFuran-catal PF09206.11 EEA28756.1 - 1.2e-147 491.3 12.1 1.7e-147 490.8 12.1 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 EEA28756.1 - 1.5e-56 190.3 0.6 2.6e-56 189.5 0.6 1.4 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain Pkinase PF00069.25 EEA28758.1 - 2.3e-22 79.6 0.0 1.9e-11 43.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28758.1 - 1.2e-10 41.2 0.0 1.5e-08 34.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase TetR_C_32 PF09209.11 EEA28758.1 - 0.037 14.0 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 EEA28758.1 - 0.39 11.7 12.8 46 5.1 0.2 5.4 5 1 0 5 5 5 0 WD domain, G-beta repeat Nucleoporin_FG PF13634.6 EEA28759.1 - 2.1e-20 73.3 85.6 4.1e-10 40.4 28.5 3.3 1 1 2 3 3 3 3 Nucleoporin FG repeat region Neur_chan_memb PF02932.16 EEA28759.1 - 0.031 14.3 0.0 0.07 13.2 0.0 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.13 EEA28759.1 - 0.47 10.4 11.2 0.57 10.1 11.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nucleoporin_FG PF13634.6 EEA28760.1 - 3.5e-15 56.6 53.6 2e-10 41.4 24.7 2.4 1 1 1 2 2 2 2 Nucleoporin FG repeat region Neur_chan_memb PF02932.16 EEA28760.1 - 0.025 14.6 0.1 0.065 13.3 0.0 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Cpn10 PF00166.21 EEA28762.1 - 5.2e-29 100.2 0.0 5.8e-29 100.0 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn10 PF00166.21 EEA28763.1 - 2.6e-26 91.5 0.0 2.8e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit XAP5 PF04921.14 EEA28764.1 - 5.5e-91 304.8 0.0 7.9e-91 304.3 0.0 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator DUF4604 PF15377.6 EEA28764.1 - 0.0023 18.4 2.1 0.0023 18.4 2.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4604) DUF1577 PF07614.11 EEA28764.1 - 0.063 12.4 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) Fip1 PF05182.13 EEA28765.1 - 2.7e-21 74.8 1.6 5.2e-21 73.9 1.6 1.5 1 0 0 1 1 1 1 Fip1 motif zf-C3HC4_3 PF13920.6 EEA28766.1 - 9.6e-10 38.2 11.5 2e-09 37.2 11.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA28766.1 - 0.058 13.3 12.5 0.12 12.2 12.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EEA28767.1 - 0.00051 19.9 8.2 0.0027 17.7 1.6 2.7 2 0 0 2 2 2 1 zinc-RING finger domain YobH PF13996.6 EEA28767.1 - 0.0091 16.0 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 YobH-like protein Ins_allergen_rp PF06757.13 EEA28767.1 - 0.016 15.2 0.5 0.027 14.4 0.5 1.4 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification Mod_r PF07200.13 EEA28767.1 - 0.027 14.6 10.6 0.045 13.9 10.6 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein zf-C3HC4_3 PF13920.6 EEA28767.1 - 0.039 13.8 2.0 0.039 13.8 2.0 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TRCF PF03461.15 EEA28767.1 - 0.096 13.1 0.3 0.46 10.9 0.1 2.0 1 1 1 2 2 2 0 TRCF domain DUF4407 PF14362.6 EEA28767.1 - 0.23 10.8 5.7 0.32 10.3 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prok-RING_4 PF14447.6 EEA28767.1 - 0.3 11.0 5.6 1.4 8.8 5.6 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EEA28767.1 - 0.67 10.3 8.3 0.11 12.8 2.2 2.7 2 1 1 3 3 3 0 Ring finger domain zf-C3HC4 PF00097.25 EEA28767.1 - 0.78 9.7 4.9 4.8 7.1 4.9 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 EEA28767.1 - 0.79 9.8 4.8 3.9 7.6 4.8 2.2 1 1 1 2 2 2 0 Double zinc ribbon zf-RING_UBOX PF13445.6 EEA28767.1 - 1.5 8.9 5.3 0.56 10.3 1.2 2.6 2 1 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA28767.1 - 9 6.2 8.2 24 4.9 3.8 3.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Glyco_transf_25 PF01755.17 EEA28768.1 - 0.0057 16.5 0.0 0.017 15.0 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) ThiF PF00899.21 EEA28769.1 - 6e-12 45.4 0.0 3.8e-11 42.8 0.0 2.3 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EEA28769.1 - 0.016 15.4 0.0 7.1 6.9 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin-activating enzyme E1 four-helix bundle Rib_5-P_isom_A PF06026.14 EEA28770.1 - 1.6e-46 158.0 0.0 3e-46 157.2 0.0 1.4 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EEA28770.1 - 0.035 14.1 0.1 6.6 6.7 0.1 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain WD40 PF00400.32 EEA28771.1 - 2.3e-13 50.4 5.3 0.065 14.1 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28771.1 - 0.013 15.8 0.0 20 5.6 0.0 4.4 2 2 3 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4979 PF16351.5 EEA28771.1 - 0.12 12.6 0.0 0.69 10.1 0.0 2.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4979) TMEM131_like PF12371.8 EEA28771.1 - 0.17 12.2 0.0 0.46 10.8 0.0 1.7 1 0 0 1 1 1 0 Transmembrane protein 131-like ATP_bind_1 PF03029.17 EEA28772.1 - 6.4e-76 255.3 0.0 8e-76 255.0 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 EEA28772.1 - 0.0026 17.7 0.0 2.6 7.9 0.0 2.3 1 1 0 2 2 2 2 AAA domain MeaB PF03308.16 EEA28772.1 - 0.0027 16.7 0.0 0.006 15.6 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EEA28772.1 - 0.004 17.2 0.0 0.046 13.8 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_10 PF12846.7 EEA28772.1 - 0.032 13.2 0.0 0.052 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain CLP1_P PF16575.5 EEA28772.1 - 0.053 13.3 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_33 PF13671.6 EEA28772.1 - 0.076 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Toast_rack_N PF17115.5 EEA28772.1 - 0.096 13.0 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 N-terminal domain of toast_rack, DUF2154 RuvB_N PF05496.12 EEA28772.1 - 0.096 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Fer4_NifH PF00142.18 EEA28772.1 - 0.15 11.5 0.1 0.32 10.4 0.1 1.5 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family RNA_helicase PF00910.22 EEA28772.1 - 0.18 12.2 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 EEA28772.1 - 0.24 11.8 2.5 0.25 11.8 0.1 2.1 2 0 0 2 2 2 0 AAA domain RNase_P_Rpp14 PF01900.19 EEA28773.1 - 1e-34 118.9 0.0 1.3e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Citrate_synt PF00285.21 EEA28774.1 - 1.3e-20 73.8 0.0 3e-18 66.0 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 EEA28774.1 - 1.3e-18 67.4 0.0 3.9e-18 65.9 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EEA28774.1 - 1.7e-14 53.9 0.1 3.1e-14 53.1 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EEA28774.1 - 1.8e-05 24.6 0.0 0.00024 20.9 0.0 2.3 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain Citrate_bind PF16114.5 EEA28775.1 - 3.3e-88 293.8 0.0 4.5e-88 293.4 0.0 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EEA28775.1 - 8.1e-08 32.1 0.0 1.3e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Fringe PF02434.16 EEA28776.1 - 6.8e-08 32.3 0.6 2.1e-06 27.4 0.6 2.7 2 1 0 2 2 2 1 Fringe-like PAN_1 PF00024.26 EEA28776.1 - 4.8e-07 29.6 1.2 8.7e-07 28.8 1.2 1.4 1 0 0 1 1 1 1 PAN domain PAN_2 PF08276.11 EEA28776.1 - 0.019 15.1 2.0 0.036 14.2 2.0 1.4 1 0 0 1 1 1 0 PAN-like domain PAN_4 PF14295.6 EEA28776.1 - 0.026 14.4 1.6 0.057 13.3 1.6 1.5 1 0 0 1 1 1 0 PAN domain Galactosyl_T PF01762.21 EEA28776.1 - 0.028 14.2 0.0 0.16 11.8 0.0 2.0 1 1 1 2 2 2 0 Galactosyltransferase CFEM PF05730.11 EEA28777.1 - 7e-15 54.9 9.8 1.4e-14 54.0 9.8 1.5 1 0 0 1 1 1 1 CFEM domain OPT PF03169.15 EEA28778.1 - 1.9e-140 469.4 51.9 2.2e-140 469.3 51.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Myelin_PLP PF01275.19 EEA28778.1 - 0.22 11.3 0.0 0.22 11.3 0.0 3.0 4 0 0 4 4 4 0 Myelin proteolipid protein (PLP or lipophilin) DNA_pol_delta_4 PF04081.13 EEA28779.1 - 1.1e-35 122.9 1.2 1.5e-35 122.4 0.5 1.5 1 1 1 2 2 2 1 DNA polymerase delta, subunit 4 ORC6 PF05460.13 EEA28780.1 - 1.7e-82 277.6 0.5 2.7e-82 276.9 0.5 1.3 1 1 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Ndc1_Nup PF09531.10 EEA28780.1 - 1.9 7.1 4.5 1.1 7.9 1.9 1.7 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Q_salvage PF10343.9 EEA28781.1 - 2.3e-134 447.3 0.1 5e-134 446.3 0.1 1.5 1 1 0 1 1 1 1 Potential Queuosine, Q, salvage protein family GATase_7 PF13537.6 EEA28781.1 - 0.051 13.5 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Glutamine amidotransferase domain DUF1563 PF07599.11 EEA28781.1 - 0.13 12.4 0.4 0.24 11.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) CT47 PF15623.6 EEA28781.1 - 0.54 10.0 9.6 0.89 9.3 9.6 1.2 1 0 0 1 1 1 0 Cancer/testis gene family 47 ThiF PF00899.21 EEA28782.1 - 6.8e-72 241.7 0.0 9.7e-72 241.2 0.0 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EEA28782.1 - 1.8e-20 73.3 0.7 4.9e-20 71.9 0.7 1.8 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EEA28782.1 - 5.8e-08 33.0 0.8 5.4e-05 23.2 0.2 2.6 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EEA28782.1 - 6.2e-05 23.4 0.0 0.00022 21.6 0.0 1.9 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EEA28782.1 - 0.021 14.9 0.0 0.048 13.7 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Seryl_tRNA_N PF02403.22 EEA28782.1 - 0.085 13.1 5.0 3.8 7.8 0.2 3.1 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Jnk-SapK_ap_N PF09744.9 EEA28782.1 - 0.14 12.4 2.6 0.25 11.5 2.6 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 CENP-Q PF13094.6 EEA28782.1 - 0.34 11.1 0.1 0.34 11.1 0.1 1.9 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit adh_short_C2 PF13561.6 EEA28783.1 - 3.5e-38 131.5 0.2 4.6e-30 104.9 0.1 3.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA28783.1 - 3.1e-34 118.2 0.6 5.7e-22 78.1 0.2 2.9 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 EEA28783.1 - 3.5e-10 40.1 0.5 1.1e-08 35.3 0.1 2.6 2 1 0 2 2 2 1 KR domain NAD_binding_4 PF07993.12 EEA28783.1 - 0.001 18.3 0.1 0.0017 17.6 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EEA28783.1 - 0.002 17.3 0.3 0.0092 15.1 0.1 2.0 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA28783.1 - 0.013 15.0 0.0 0.034 13.6 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EEA28783.1 - 0.03 14.2 0.1 4.8 7.0 0.1 2.2 1 1 1 2 2 2 0 NAD(P)H-binding DFP PF04127.15 EEA28783.1 - 0.033 14.0 0.4 1.8 8.3 0.1 2.3 1 1 1 2 2 2 0 DNA / pantothenate metabolism flavoprotein Shikimate_DH PF01488.20 EEA28783.1 - 0.052 13.6 0.0 4.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Skp1_POZ PF03931.15 EEA28784.1 - 3.3e-09 36.8 0.0 5e-09 36.2 0.0 1.3 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain tRNA_int_end_N2 PF12928.7 EEA28785.1 - 4.8e-27 93.9 0.0 9e-27 93.1 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EEA28785.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain DUF1664 PF07889.12 EEA28786.1 - 0.035 14.1 0.2 0.039 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IFT81_CH PF18383.1 EEA28786.1 - 0.051 13.8 0.2 0.053 13.8 0.2 1.1 1 0 0 1 1 1 0 Intraflagellar transport 81 calponin homology domain Death PF00531.22 EEA28786.1 - 0.079 13.1 0.9 0.13 12.4 0.5 1.6 1 1 1 2 2 2 0 Death domain Arrestin_C PF02752.22 EEA28787.1 - 1.9e-12 47.8 0.0 5.7e-12 46.2 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Pro_isomerase PF00160.21 EEA28788.1 - 9.3e-36 123.5 0.0 5e-35 121.1 0.0 1.8 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-CDGSH PF09360.10 EEA28788.1 - 0.073 13.3 0.2 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 Iron-binding zinc finger CDGSH type zf-ZPR1 PF03367.13 EEA28789.1 - 8.4e-106 350.7 0.1 5e-54 182.5 0.0 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain DBR1 PF05011.13 EEA28790.1 - 2.1e-41 141.6 1.4 3.1e-41 141.1 0.2 1.9 2 0 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EEA28790.1 - 5.2e-05 23.8 1.5 8.9e-05 23.1 1.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RTP1_C1 PF10363.9 EEA28791.1 - 8.3e-35 119.4 0.9 1.8e-32 111.8 0.1 3.7 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EEA28791.1 - 2.8e-12 46.1 0.3 4.8e-11 42.1 0.2 2.8 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 2 GlutR_N PF05201.15 EEA28791.1 - 0.018 14.8 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain Polysacc_deac_1 PF01522.21 EEA28792.1 - 5.3e-28 97.4 0.0 9.8e-28 96.5 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EEA28792.1 - 3.7e-06 27.3 16.3 8.2e-06 26.2 16.3 1.6 1 0 0 1 1 1 1 Chitin recognition protein RAD51_interact PF15696.5 EEA28793.1 - 0.0021 18.1 0.1 0.005 16.9 0.1 1.6 1 0 0 1 1 1 1 RAD51 interacting motif Clathrin PF00637.20 EEA28794.1 - 1.5e-22 80.0 0.9 3.3e-20 72.4 0.5 2.8 2 0 0 2 2 2 1 Region in Clathrin and VPS VPS11_C PF12451.8 EEA28794.1 - 3.1e-20 72.1 0.6 7.9e-20 70.8 0.6 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EEA28794.1 - 9.1e-07 28.8 5.9 2.1e-06 27.6 5.9 1.7 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EEA28794.1 - 1e-06 28.5 5.8 2.4e-06 27.3 5.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA28794.1 - 0.0005 20.0 6.0 0.0011 18.9 6.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain WD40_like PF17005.5 EEA28794.1 - 0.0007 19.0 0.2 0.0057 16.0 0.1 2.0 2 0 0 2 2 2 1 WD40-like domain TPR_11 PF13414.6 EEA28794.1 - 0.00081 19.0 0.1 0.0023 17.6 0.1 1.8 1 0 0 1 1 1 1 TPR repeat zf-RING_2 PF13639.6 EEA28794.1 - 0.0012 19.1 6.2 0.0028 18.0 6.2 1.6 1 0 0 1 1 1 1 Ring finger domain TPR_14 PF13428.6 EEA28794.1 - 0.0026 18.4 0.2 0.29 12.1 0.0 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat zf-rbx1 PF12678.7 EEA28794.1 - 0.019 15.2 4.1 0.04 14.2 4.1 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF4810 PF16068.5 EEA28794.1 - 0.02 15.4 0.2 4.7 7.8 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) zf-C3HC4 PF00097.25 EEA28794.1 - 0.047 13.6 5.3 0.095 12.6 5.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_2 PF07719.17 EEA28794.1 - 0.068 13.3 0.7 0.72 10.1 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Vps39_2 PF10367.9 EEA28794.1 - 0.091 13.2 0.6 0.3 11.6 0.6 1.9 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-ANAPC11 PF12861.7 EEA28794.1 - 0.29 11.2 2.0 0.71 10.0 2.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_12 PF13424.6 EEA28794.1 - 0.29 11.4 1.8 1.3 9.4 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 EEA28794.1 - 0.91 9.6 5.5 3.8 7.6 5.6 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FlgN PF05130.12 EEA28796.1 - 0.036 14.6 0.1 0.056 14.0 0.1 1.2 1 0 0 1 1 1 0 FlgN protein LRR_4 PF12799.7 EEA28797.1 - 5.2e-31 106.2 25.9 3.4e-05 24.1 1.1 7.8 7 0 0 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA28797.1 - 4.9e-25 87.1 34.3 4.6e-07 29.5 0.1 7.9 5 1 2 7 7 7 5 Leucine rich repeat LRR_9 PF14580.6 EEA28797.1 - 2e-10 40.4 5.7 0.00056 19.5 0.3 4.4 2 1 2 4 4 4 2 Leucine-rich repeat LRR_1 PF00560.33 EEA28797.1 - 3.7e-05 23.7 22.1 13 6.8 0.0 10.1 7 3 0 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 EEA28797.1 - 0.045 13.8 30.6 9.7 6.5 0.2 9.5 10 0 0 10 10 10 0 Leucine Rich repeat ApbA PF02558.16 EEA28798.1 - 7.7e-28 97.1 0.1 1e-27 96.7 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EEA28798.1 - 4.8e-25 88.2 0.0 1.1e-24 87.0 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal NAD_binding_7 PF13241.6 EEA28798.1 - 0.026 15.0 0.0 0.053 14.0 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding IlvN PF07991.12 EEA28798.1 - 0.042 13.4 0.3 0.18 11.4 0.3 2.1 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ThiF PF00899.21 EEA28798.1 - 0.12 11.7 0.4 0.32 10.3 0.2 1.7 2 0 0 2 2 2 0 ThiF family IPK PF03770.16 EEA28800.1 - 8.9e-59 198.7 0.0 1.6e-58 197.8 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Pam17 PF08566.10 EEA28800.1 - 0.056 13.3 0.1 0.15 11.9 0.1 1.6 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 MFS_1 PF07690.16 EEA28801.1 - 1.9e-15 56.6 15.5 1.9e-15 56.6 15.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EEA28801.1 - 2.4e-08 33.8 5.0 5.7e-08 32.6 5.0 1.6 1 0 0 1 1 1 1 Nodulin-like ERCC4 PF02732.15 EEA28802.1 - 2e-35 122.3 0.3 3.7e-35 121.4 0.3 1.5 1 0 0 1 1 1 1 ERCC4 domain DUF4744 PF15918.5 EEA28802.1 - 0.17 12.7 0.3 0.17 12.7 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4744) DUF3043 PF11241.8 EEA28802.1 - 1.1 9.2 12.6 0.019 15.0 5.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) DUF1682 PF07946.14 EEA28802.1 - 1.9 7.6 14.3 3.5 6.7 14.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Trnau1ap PF17654.1 EEA28802.1 - 3 8.8 6.2 1.6 9.7 1.7 2.5 2 0 0 2 2 2 0 Selenocysteine tRNA 1 associated proteins eIF3_subunit PF08597.10 EEA28802.1 - 3.9 7.3 29.4 2.9 7.8 18.1 3.1 3 0 0 3 3 3 0 Translation initiation factor eIF3 subunit Spore_coat_CotO PF14153.6 EEA28802.1 - 4.3 7.2 17.3 5.9 6.8 13.5 2.4 2 0 0 2 2 2 0 Spore coat protein CotO DUF2203 PF09969.9 EEA28802.1 - 4.5 8.0 9.3 1.6 9.5 5.5 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) MCM_bind PF09739.9 EEA28802.1 - 4.6 5.6 12.8 1.3 7.4 6.6 2.1 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor Use1 PF09753.9 EEA28802.1 - 5.8 6.6 15.0 0.37 10.5 8.9 2.1 3 0 0 3 3 3 0 Membrane fusion protein Use1 PNP_UDP_1 PF01048.20 EEA28803.1 - 3.6e-06 26.4 0.0 1.5e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily Prok-RING_1 PF14446.6 EEA28803.1 - 0.012 15.5 6.1 0.041 13.8 6.1 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 EEA28803.1 - 0.096 12.6 17.5 0.023 14.6 12.7 2.5 2 1 0 2 2 2 0 PHD-finger Glycos_transf_1 PF00534.20 EEA28804.1 - 3.7e-33 114.5 0.1 8.4e-32 110.1 0.1 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EEA28804.1 - 1.7e-17 63.9 0.0 2.6e-16 60.1 0.1 2.4 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EEA28804.1 - 1.1e-12 48.6 0.0 4.1e-12 46.7 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EEA28804.1 - 1.6e-05 25.4 0.1 5.9e-05 23.6 0.1 1.9 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EEA28804.1 - 0.0071 16.7 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_5 PF16994.5 EEA28804.1 - 0.087 12.4 0.0 0.24 11.0 0.0 1.7 2 0 0 2 2 2 0 Glycosyl-transferase family 4 ACT_3 PF10000.9 EEA28805.1 - 1e-23 83.0 0.1 1.9e-23 82.1 0.1 1.5 1 0 0 1 1 1 1 ACT domain Sulf_transp PF04143.14 EEA28806.1 - 0.012 15.2 1.6 0.012 15.2 1.6 1.5 2 0 0 2 2 2 0 Sulphur transport SPC25 PF06703.11 EEA28806.1 - 0.12 12.1 1.6 0.55 10.0 0.4 2.2 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Cytochrom_B_C PF00032.17 EEA28806.1 - 1.2 9.5 5.7 1.8 8.9 3.1 2.5 2 1 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD Kinesin PF00225.23 EEA28807.1 - 8.6e-89 297.7 3.7 1.3e-88 297.1 0.0 2.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EEA28807.1 - 6.2e-19 68.4 0.0 3.2e-15 56.4 0.0 3.7 2 1 0 3 3 3 2 Microtubule binding DUF4108 PF13390.6 EEA28807.1 - 0.091 12.7 4.7 0.21 11.5 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) SLATT_5 PF18160.1 EEA28807.1 - 0.2 11.0 3.0 0.25 10.7 0.0 2.7 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF3584 PF12128.8 EEA28807.1 - 0.69 7.3 148.3 0.17 9.3 21.1 5.8 4 1 1 5 5 5 0 Protein of unknown function (DUF3584) SirA PF10747.9 EEA28807.1 - 2.8 8.3 9.3 4.2 7.7 3.5 3.5 2 0 0 2 2 2 0 Sporulation inhibitor of replication protein SirA Polo_box_3 PF18544.1 EEA28807.1 - 3 8.5 9.8 5.6 7.7 0.1 5.3 5 0 0 5 5 5 0 Polo box domain DUF2235 PF09994.9 EEA28808.1 - 3.1e-76 256.5 0.0 3.9e-76 256.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) An_peroxidase PF03098.15 EEA28809.1 - 3.9e-39 134.6 0.1 8.8e-17 60.9 0.0 3.3 2 1 1 3 3 3 3 Animal haem peroxidase PorB PF11565.8 EEA28809.1 - 0.094 13.1 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 Alpha helical Porin B TPR_12 PF13424.6 EEA28810.1 - 4.9e-34 116.5 11.2 2.9e-13 49.9 0.1 6.3 2 1 4 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 EEA28810.1 - 8.3e-20 70.0 9.0 0.00077 19.3 0.0 8.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EEA28810.1 - 8.5e-07 29.4 8.8 1.2 9.7 0.3 6.1 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA28810.1 - 0.00012 22.5 4.9 1.3 10.0 0.3 5.9 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA28810.1 - 0.00017 21.2 1.7 0.22 11.4 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA28810.1 - 0.00024 21.0 4.1 0.47 10.7 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA28810.1 - 0.00054 20.0 0.3 3.8 8.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA28810.1 - 0.00091 19.8 2.2 17 6.1 0.0 4.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EEA28810.1 - 0.0012 19.2 5.7 3 8.7 0.1 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA28810.1 - 0.0022 18.2 0.1 3.1 8.1 0.0 4.2 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF934 PF06073.12 EEA28810.1 - 0.042 13.8 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF934) TPR_7 PF13176.6 EEA28810.1 - 0.05 13.6 7.2 9.1 6.6 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA28810.1 - 1.4 9.7 5.0 8.4 7.3 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat p450 PF00067.22 EEA28811.1 - 1.2e-47 162.7 0.0 1.5e-47 162.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sad1_UNC PF07738.13 EEA28812.1 - 1.1e-12 48.1 0.0 4.6e-10 39.6 0.0 2.4 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal WD40 PF00400.32 EEA28813.1 - 1.3e-30 104.9 10.9 2.8e-06 28.0 0.6 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 EEA28813.1 - 4e-10 39.0 7.7 0.014 14.1 0.4 5.3 3 1 3 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EEA28813.1 - 1.5e-07 31.6 0.0 0.094 13.0 0.0 5.1 3 2 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain DUF5046 PF16465.5 EEA28813.1 - 0.013 15.0 0.3 0.3 10.5 0.0 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF5046) ROS_MUCR PF05443.11 EEA28813.1 - 0.12 12.4 0.7 3.1 7.9 0.2 2.5 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein Ax_dynein_light PF10211.9 EEA28813.1 - 0.27 11.2 4.4 0.54 10.2 4.4 1.5 1 0 0 1 1 1 0 Axonemal dynein light chain RRN3 PF05327.11 EEA28813.1 - 0.39 9.2 3.6 0.69 8.4 3.6 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF1664 PF07889.12 EEA28813.1 - 1.2 9.2 3.6 3.9 7.5 3.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4611 PF15387.6 EEA28813.1 - 2.6 8.3 13.0 0.34 11.2 5.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) APG6_N PF17675.1 EEA28813.1 - 7.4 7.1 12.4 19 5.7 12.4 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region CM_2 PF01817.21 EEA28814.1 - 0.00038 20.7 2.1 0.033 14.6 0.1 3.1 3 1 0 3 3 3 2 Chorismate mutase type II BCIP PF13862.6 EEA28815.1 - 3.2e-74 249.2 0.1 4.7e-74 248.6 0.1 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein AAR2 PF05282.11 EEA28816.1 - 0.55 9.6 4.0 0.53 9.6 4.0 1.1 1 0 0 1 1 1 0 AAR2 protein Mannosyl_trans3 PF11051.8 EEA28817.1 - 1.6e-53 181.8 0.0 2e-36 125.8 0.0 2.2 1 1 1 2 2 2 2 Mannosyltransferase putative Fungal_trans_2 PF11951.8 EEA28818.1 - 3.4e-54 184.1 0.6 7.4e-54 183.0 0.6 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28818.1 - 0.00049 20.2 4.2 0.0011 19.1 4.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DJ-1_PfpI PF01965.24 EEA28819.1 - 5.7e-09 36.0 0.0 1.7e-08 34.5 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family adh_short PF00106.25 EEA28820.1 - 3.2e-13 49.6 0.1 4.8e-13 49.0 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28820.1 - 1.1e-07 31.7 0.0 1.6e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA28820.1 - 0.0002 21.4 0.0 0.00028 20.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Peptidase_A4 PF01828.17 EEA28821.1 - 5.6e-64 215.5 14.2 6.5e-64 215.2 14.2 1.0 1 0 0 1 1 1 1 Peptidase A4 family TMEM52 PF14979.6 EEA28822.1 - 0.027 14.4 0.8 0.052 13.5 0.8 1.4 1 0 0 1 1 1 0 Transmembrane 52 TMEM52 PF14979.6 EEA28823.1 - 0.22 11.5 0.5 0.37 10.7 0.5 1.4 1 0 0 1 1 1 0 Transmembrane 52 Ank_2 PF12796.7 EEA28824.1 - 1.9e-81 268.7 11.8 1.5e-11 44.7 0.0 10.5 7 2 4 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA28824.1 - 7e-61 201.9 26.4 8.1e-12 45.4 0.2 15.2 9 6 7 16 16 16 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA28824.1 - 5.5e-58 186.1 30.7 0.00011 22.4 0.1 19.3 20 2 1 21 21 19 12 Ankyrin repeat Ank PF00023.30 EEA28824.1 - 3.4e-57 188.5 35.9 5.7e-06 26.5 0.1 19.5 18 2 0 18 18 18 11 Ankyrin repeat Ank_5 PF13857.6 EEA28824.1 - 8.8e-45 150.2 16.9 2.5e-07 30.8 0.0 10.6 11 0 0 11 11 10 8 Ankyrin repeats (many copies) NACHT PF05729.12 EEA28824.1 - 1.2e-09 38.3 0.2 3.2e-09 36.9 0.2 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EEA28824.1 - 3e-09 37.5 0.0 1.2e-08 35.6 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA28824.1 - 1.9e-06 28.2 0.0 1.2e-05 25.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 EEA28824.1 - 0.0015 18.6 0.0 0.0035 17.4 0.0 1.6 1 0 0 1 1 1 1 Torsin RNA_helicase PF00910.22 EEA28824.1 - 0.0029 18.0 0.0 0.0097 16.3 0.0 2.0 1 0 0 1 1 1 1 RNA helicase AAA PF00004.29 EEA28824.1 - 0.078 13.4 0.0 0.23 11.9 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EEA28824.1 - 0.12 12.5 0.0 0.85 9.7 0.0 2.4 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA28824.1 - 0.17 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Glyco_hydro_cc PF11790.8 EEA28825.1 - 4.5e-57 193.4 7.5 5.3e-57 193.1 7.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Dicty_CAR PF05462.11 EEA28827.1 - 6.2e-13 48.6 21.3 8.2e-12 44.9 12.8 2.4 2 1 1 3 3 3 2 Slime mold cyclic AMP receptor Git3 PF11710.8 EEA28827.1 - 2.5e-08 33.9 16.6 2.5e-08 33.9 16.6 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 EEA28827.1 - 9.7e-06 25.1 8.9 1.8e-05 24.2 8.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Frizzled PF01534.17 EEA28827.1 - 0.016 14.3 17.9 0.85 8.6 16.4 2.7 2 1 0 2 2 2 0 Frizzled/Smoothened family membrane region 7TM_GPCR_Srsx PF10320.9 EEA28827.1 - 0.6 9.4 16.2 0.15 11.5 12.6 1.8 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx adh_short PF00106.25 EEA28828.1 - 1.1e-13 51.1 0.0 3.1e-10 39.8 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28828.1 - 1.2e-06 28.3 0.0 1.8e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NLE PF08154.12 EEA28828.1 - 0.04 14.4 0.2 0.32 11.6 0.0 2.2 2 0 0 2 2 2 0 NLE (NUC135) domain DIOX_N PF14226.6 EEA28829.1 - 3.5e-20 72.9 0.3 7.7e-20 71.8 0.3 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EEA28829.1 - 2.9e-12 47.0 0.0 7.4e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EEA28830.1 - 9.5e-34 116.9 40.6 2.1e-31 109.1 23.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Bac_luciferase PF00296.20 EEA28831.1 - 1.9e-56 191.8 0.1 2.9e-56 191.2 0.1 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase DUF5551 PF17705.1 EEA28831.1 - 0.048 13.3 0.0 0.59 9.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5551) DUF1275 PF06912.11 EEA28832.1 - 1.3e-43 149.2 11.1 3e-43 148.0 11.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Zn_clus PF00172.18 EEA28832.1 - 7.5e-09 35.6 15.2 1.5e-08 34.6 15.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EEA28832.1 - 3.3e-08 32.7 0.5 5.7e-08 32.0 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain LIP PF03583.14 EEA28833.1 - 1.4e-07 31.1 0.3 0.014 14.7 0.0 2.2 2 0 0 2 2 2 2 Secretory lipase Abhydrolase_6 PF12697.7 EEA28833.1 - 4.1e-07 30.8 0.8 6.5e-07 30.2 0.8 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA28833.1 - 3.8e-06 26.3 0.1 3.9e-05 23.0 0.1 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA28833.1 - 0.029 14.0 0.0 4.5 6.8 0.0 2.5 2 1 0 2 2 2 0 alpha/beta hydrolase fold Peroxidase_2 PF01328.17 EEA28834.1 - 6.3e-50 170.3 0.0 7.6e-50 170.0 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 Amidohydro_2 PF04909.14 EEA28835.1 - 1.9e-31 110.0 0.0 2.5e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Glyco_hydro_3_C PF01915.22 EEA28836.1 - 1.3e-53 182.0 0.0 2.3e-53 181.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EEA28836.1 - 1.5e-36 126.4 0.0 2.8e-36 125.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EEA28836.1 - 3.1e-16 59.2 0.1 5.9e-16 58.3 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PTR2 PF00854.21 EEA28837.1 - 4.6e-52 177.2 8.4 6.1e-52 176.8 8.4 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 EEA28837.1 - 1.8e-08 33.7 32.2 6.5e-08 31.9 32.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 EEA28837.1 - 0.14 12.2 0.1 0.14 12.2 0.1 4.3 5 0 0 5 5 5 0 Putative Actinobacterial Holin-X, holin superfamily III Alpha-amylase PF00128.24 EEA28839.1 - 0.00014 21.5 1.1 0.0002 21.0 1.1 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain WD40 PF00400.32 EEA28840.1 - 0.12 13.3 0.4 0.82 10.6 0.1 2.6 2 0 0 2 2 2 0 WD domain, G-beta repeat Polyketide_cyc PF03364.20 EEA28841.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport TAN PF11640.8 EEA28841.1 - 0.16 12.1 1.2 8.4 6.5 0.0 2.4 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair Ndc1_Nup PF09531.10 EEA28841.1 - 9.6 4.8 9.5 19 3.8 9.5 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup adh_short PF00106.25 EEA28842.1 - 1.1e-24 87.0 0.0 1.4e-24 86.7 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA28842.1 - 6.9e-20 71.6 0.0 9e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA28842.1 - 2e-05 24.6 0.0 2.9e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 KR domain DUF460 PF04312.13 EEA28842.1 - 0.074 12.8 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF460) DFRP_C PF16543.5 EEA28843.1 - 1.9e-25 89.2 4.6 1.9e-25 89.2 4.6 3.9 3 1 1 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 EEA28843.1 - 1.3e-05 24.9 2.9 1.3e-05 24.9 2.9 2.3 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EEA28843.1 - 1.7e-05 24.5 10.8 0.00055 19.7 3.1 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 EEA28843.1 - 0.00012 22.7 15.3 0.00035 21.2 5.7 3.6 3 2 0 3 3 3 2 Torus domain zf-CCCH_3 PF15663.5 EEA28843.1 - 0.00016 21.8 0.4 0.14 12.4 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 EEA28843.1 - 0.00034 20.5 9.2 0.00034 20.5 9.2 3.3 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH_2 PF14608.6 EEA28843.1 - 0.071 13.6 15.2 0.67 10.5 5.8 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger LRS4 PF10422.9 EEA28843.1 - 1.3 8.6 8.7 0.93 9.0 4.8 2.2 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 zf-TRAF PF02176.18 EEA28844.1 - 2.2e-11 44.3 26.5 1.3e-08 35.4 5.7 4.5 1 1 5 6 6 6 4 TRAF-type zinc finger zf-ACC PF17848.1 EEA28844.1 - 6.9e-10 38.8 7.0 3.7e-06 26.9 0.0 4.3 3 0 0 3 3 3 2 Acetyl-coA carboxylase zinc finger domain zf-TRAF_2 PF15965.5 EEA28844.1 - 1.3e-09 38.3 25.0 7.2e-08 32.8 10.2 2.9 1 1 0 2 2 2 2 TRAF-like zinc-finger zf-RING_UBOX PF13445.6 EEA28844.1 - 9e-08 32.0 10.9 9e-08 32.0 10.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EEA28844.1 - 1.8e-07 31.2 12.0 1.8e-07 31.2 12.0 2.6 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EEA28844.1 - 3.4e-06 27.3 13.2 3.4e-06 27.3 13.2 3.7 2 1 1 3 3 1 1 Ring finger domain zf-RING_5 PF14634.6 EEA28844.1 - 5.7e-06 26.2 10.9 5.7e-06 26.2 10.9 3.3 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EEA28844.1 - 6.3e-06 26.0 12.4 6.3e-06 26.0 12.4 3.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA28844.1 - 0.0021 17.9 13.1 0.0021 17.9 13.1 4.1 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-dskA_traR PF01258.17 EEA28844.1 - 0.021 14.8 1.3 3.5 7.6 0.3 2.8 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-DNA_Pol PF08996.10 EEA28844.1 - 0.45 10.2 23.2 0.029 14.1 12.3 2.6 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger SNARE PF05739.19 EEA28845.1 - 4.1e-10 39.5 2.1 6.9e-10 38.8 2.1 1.4 1 0 0 1 1 1 1 SNARE domain Cir_Bir_Yir PF06022.11 EEA28845.1 - 0.0014 18.2 0.1 0.002 17.7 0.1 1.4 1 1 0 1 1 1 1 Plasmodium variant antigen protein Cir/Yir/Bir Phage_GP20 PF06810.11 EEA28845.1 - 0.009 15.8 0.9 12 5.7 0.1 3.1 2 1 1 3 3 3 1 Phage minor structural protein GP20 XhlA PF10779.9 EEA28845.1 - 0.014 15.6 12.1 0.09 13.0 5.8 3.2 3 1 0 3 3 3 0 Haemolysin XhlA Use1 PF09753.9 EEA28845.1 - 0.023 14.4 1.0 0.071 12.8 1.0 2.0 1 1 0 1 1 1 0 Membrane fusion protein Use1 Synaptobrevin PF00957.21 EEA28845.1 - 0.11 12.3 0.1 0.34 10.7 0.1 1.9 1 0 0 1 1 1 0 Synaptobrevin DHR10 PF18595.1 EEA28845.1 - 0.15 12.1 4.4 5.4 7.1 0.5 2.6 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain Fusion_gly PF00523.18 EEA28845.1 - 0.16 10.2 0.1 0.23 9.6 0.1 1.3 1 0 0 1 1 1 0 Fusion glycoprotein F0 DUF745 PF05335.13 EEA28845.1 - 0.21 11.3 0.1 0.42 10.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) HrpB7 PF09486.10 EEA28845.1 - 0.74 10.2 6.8 0.16 12.3 1.3 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) PilJ PF13675.6 EEA28845.1 - 1 9.4 5.2 0.89 9.6 0.2 2.5 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Snapin_Pallidin PF14712.6 EEA28845.1 - 1.2 9.6 4.6 0.58 10.6 0.8 2.3 2 1 0 2 2 2 0 Snapin/Pallidin cwf21 PF08312.12 EEA28845.1 - 1.4 9.1 6.1 2.1 8.6 1.0 3.0 2 1 1 3 3 3 0 cwf21 domain FliJ PF02050.16 EEA28845.1 - 1.8 8.8 7.5 3.5 7.9 2.2 2.8 2 2 1 3 3 3 0 Flagellar FliJ protein DUF4452 PF14618.6 EEA28847.1 - 4.5e-73 244.7 11.5 6.5e-73 244.2 11.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) Cyclin_N PF00134.23 EEA28848.1 - 9.7e-10 38.3 0.8 2e-09 37.2 0.8 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EEA28848.1 - 0.015 15.6 1.5 0.048 14.0 0.3 2.3 2 0 0 2 2 2 0 Cyclin C-terminal domain Mito_carr PF00153.27 EEA28849.1 - 6.1e-66 218.4 6.0 2.8e-24 84.9 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 EEA28849.1 - 1.1e-21 74.7 5.9 1.2e-05 24.5 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EEA28849.1 - 1.2e-18 65.4 5.4 1.5e-05 24.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EEA28849.1 - 4.4e-18 65.5 5.8 7.1e-10 39.2 1.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA28849.1 - 4.2e-16 57.6 7.8 7.3e-05 22.1 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EEA28849.1 - 3e-09 36.6 5.5 6.5e-05 22.7 0.3 3.5 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EEA28849.1 - 1.8e-06 28.2 0.1 0.007 16.7 0.2 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Serine_protease PF18405.1 EEA28849.1 - 0.0013 18.0 0.8 1.1 8.3 0.0 3.2 3 0 0 3 3 3 1 Gammaproteobacterial serine protease EF-hand_9 PF14658.6 EEA28849.1 - 0.12 12.7 0.0 2.1 8.8 0.0 2.7 1 1 2 3 3 3 0 EF-hand domain EF-hand_10 PF14788.6 EEA28849.1 - 0.13 12.1 0.9 15 5.6 0.1 2.8 3 0 0 3 3 3 0 EF hand EF-hand_4 PF12763.7 EEA28849.1 - 0.17 11.8 2.3 12 5.9 0.1 3.1 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand GST_N_2 PF13409.6 EEA28850.1 - 1.5e-22 79.7 0.2 5.1e-22 78.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EEA28850.1 - 5.2e-15 55.2 0.0 1e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA28850.1 - 1e-07 32.1 0.1 2.7e-07 30.7 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EEA28850.1 - 1.5e-05 25.3 0.1 0.00031 21.1 0.1 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EEA28850.1 - 0.00057 20.0 0.1 0.0012 19.0 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain QIL1 PF15884.5 EEA28850.1 - 0.11 13.1 0.0 0.47 11.1 0.0 2.0 3 0 0 3 3 3 0 MICOS complex subunit MIC13, QIL1 Glyco_hydro_18 PF00704.28 EEA28851.1 - 8.2e-64 216.3 2.1 1.3e-63 215.6 2.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EEA28851.1 - 2e-10 40.9 19.6 2e-10 40.9 19.6 4.4 4 0 0 4 4 4 2 Chitin recognition protein PLAC PF08686.11 EEA28851.1 - 7.8 7.3 10.5 0.094 13.5 1.9 2.4 2 0 0 2 2 2 0 PLAC (protease and lacunin) domain LysM PF01476.20 EEA28852.1 - 0.00078 19.5 0.2 1.7 8.8 0.0 3.0 3 0 0 3 3 3 2 LysM domain Chitin_bind_1 PF00187.19 EEA28853.1 - 1.5e-11 44.5 96.1 1.9e-05 25.0 21.8 5.2 5 0 0 5 5 5 3 Chitin recognition protein LysM PF01476.20 EEA28853.1 - 0.00097 19.1 0.2 1.8 8.7 0.0 3.0 3 0 0 3 3 3 2 LysM domain LysM PF01476.20 EEA28854.1 - 0.00027 20.9 0.2 1 9.5 0.0 3.1 3 1 0 3 3 3 2 LysM domain ThiF PF00899.21 EEA28856.1 - 1.4e-113 378.3 0.0 1.7e-75 253.5 0.0 2.3 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EEA28856.1 - 3.5e-96 322.0 0.1 1.6e-95 319.8 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EEA28856.1 - 3.6e-31 107.7 0.1 7.3e-31 106.7 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 EEA28856.1 - 2.8e-30 104.3 0.1 5.6e-30 103.4 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EEA28856.1 - 1.5e-25 89.1 2.0 3.8e-25 87.9 1.5 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle GCP_N_terminal PF17681.1 EEA28857.1 - 9.6e-34 117.4 0.1 2.2e-33 116.2 0.1 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EEA28857.1 - 4.1e-26 92.2 0.2 8.3e-26 91.2 0.2 1.5 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal adh_short_C2 PF13561.6 EEA28858.1 - 1.1e-53 182.2 1.1 1.4e-53 181.9 1.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA28858.1 - 7.9e-43 146.2 0.8 9.9e-43 145.9 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA28858.1 - 3.5e-13 49.9 0.3 5.3e-13 49.3 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA28858.1 - 6.9e-05 22.4 0.1 9.3e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EEA28858.1 - 0.00017 21.1 0.0 0.00023 20.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase MFS_1 PF07690.16 EEA28859.1 - 4.3e-31 108.1 26.0 4.3e-31 108.1 26.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA28859.1 - 7.6 5.3 19.7 0.9 8.3 5.6 3.1 2 1 1 3 3 3 0 MFS_1 like family GILT PF03227.16 EEA28861.1 - 4.3e-16 59.1 0.5 1.6e-15 57.2 0.5 2.0 1 1 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Fungal_trans PF04082.18 EEA28862.1 - 2.3e-18 66.2 2.5 2.6e-18 66.0 0.9 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Amidohydro_1 PF01979.20 EEA28863.1 - 1.2e-46 159.6 0.0 1.6e-46 159.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EEA28863.1 - 2.5e-19 70.1 0.2 1.2e-12 48.0 0.0 2.3 2 1 0 2 2 2 2 Amidohydrolase family MFS_1 PF07690.16 EEA28864.1 - 1.9e-36 125.7 33.7 1.9e-36 125.7 33.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EEA28864.1 - 1.5e-06 27.8 11.5 6.3e-05 22.4 4.7 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF3938 PF13074.6 EEA28864.1 - 0.16 12.2 2.1 0.84 9.9 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3938) Hexokinase_1 PF00349.21 EEA28865.1 - 2.3e-62 210.5 0.0 3.1e-62 210.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EEA28865.1 - 5.9e-43 147.0 0.0 1.1e-41 142.8 0.0 2.2 1 1 0 1 1 1 1 Hexokinase DUF1509 PF07420.11 EEA28865.1 - 1.7 7.5 5.9 0.18 10.7 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1509) TFIIA_gamma_C PF02751.14 EEA28866.1 - 2.8e-25 88.2 1.9 4e-25 87.7 1.9 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 EEA28866.1 - 4.1e-16 58.7 0.0 6.4e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain PBP1_TM PF14812.6 EEA28867.1 - 3.1 8.2 15.7 0.75 10.2 4.2 3.8 2 1 1 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TPR_12 PF13424.6 EEA28868.1 - 4.1e-17 62.3 4.1 0.00019 21.7 0.4 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EEA28868.1 - 9.9e-12 44.3 5.5 7.5e-09 35.2 0.0 4.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA28868.1 - 0.0028 17.6 0.7 1.1 9.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Rax2 PF12768.7 EEA28868.1 - 0.0059 16.1 0.0 0.042 13.3 0.0 2.0 1 1 1 2 2 2 1 Cortical protein marker for cell polarity TPR_1 PF00515.28 EEA28868.1 - 0.01 15.6 2.5 0.44 10.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat VSP PF03302.13 EEA28868.1 - 0.021 13.7 1.1 0.03 13.2 1.1 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein TPR_6 PF13174.6 EEA28868.1 - 0.021 15.4 4.3 15 6.5 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA28868.1 - 0.054 12.9 1.3 0.32 10.3 0.2 2.0 1 1 1 2 2 2 0 MalT-like TPR region TPR_8 PF13181.6 EEA28868.1 - 0.072 13.3 1.0 12 6.4 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EEA28868.1 - 0.08 13.0 3.4 0.46 10.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat PGF-CTERM PF18204.1 EEA28868.1 - 0.34 11.0 0.8 0.6 10.2 0.8 1.4 1 0 0 1 1 1 0 PGF-CTERM motif DUF92 PF01940.16 EEA28869.1 - 2.5e-87 292.2 9.9 3e-87 291.9 9.9 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 DUF2644 PF10841.8 EEA28869.1 - 2.1 8.6 7.2 3.4 8.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2644) Pep1_7 PF17232.2 EEA28870.1 - 0.0048 17.3 0.3 0.012 16.1 0.3 1.6 1 0 0 1 1 1 1 Elicitor peptide 1-7 DUF4940 PF16298.5 EEA28870.1 - 0.026 14.2 0.5 0.037 13.7 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4940) AAR2 PF05282.11 EEA28870.1 - 0.028 13.8 1.6 0.042 13.3 1.6 1.2 1 0 0 1 1 1 0 AAR2 protein ALMT PF11744.8 EEA28870.1 - 0.22 10.3 1.0 0.31 9.8 1.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Aldedh PF00171.22 EEA28871.1 - 1.6e-130 435.7 0.1 1.8e-130 435.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EEA28871.1 - 3.7e-06 26.2 0.0 6.1e-06 25.5 0.0 1.5 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 EEA28871.1 - 0.012 15.1 0.1 0.13 11.7 0.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) Haem_oxygenas_2 PF14518.6 EEA28871.1 - 0.17 11.7 0.0 21 4.8 0.0 2.2 2 0 0 2 2 2 0 Iron-containing redox enzyme Methyltransf_33 PF10017.9 EEA28872.1 - 7e-85 284.9 0.0 9.7e-85 284.4 0.0 1.2 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 EEA28872.1 - 1.2e-20 74.2 3.2 4.9e-20 72.2 3.2 1.9 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EEA28872.1 - 4.1e-06 27.3 4.5 5.6e-05 23.6 0.9 3.1 2 1 1 3 3 3 1 DinB superfamily Radical_SAM PF04055.21 EEA28873.1 - 2.8e-10 40.8 0.0 4.3e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EEA28873.1 - 8.2e-05 22.9 0.0 0.00017 21.9 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain KSHV_K8 PF07188.11 EEA28873.1 - 0.021 14.2 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein Fer4_14 PF13394.6 EEA28873.1 - 0.037 14.2 0.0 0.092 12.9 0.0 1.7 1 0 0 1 1 1 0 4Fe-4S single cluster domain Fungal_trans PF04082.18 EEA28874.1 - 1e-33 116.5 0.0 1.8e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28874.1 - 2.2e-08 34.1 10.7 3.6e-08 33.4 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_pol PF00940.19 EEA28875.1 - 1.4e-181 603.8 0.0 2.4e-181 603.1 0.0 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EEA28875.1 - 3.6e-89 299.5 0.1 5.2e-89 298.9 0.1 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Gemini_AL3 PF01407.17 EEA28875.1 - 0.05 13.5 0.0 0.76 9.6 0.0 2.3 2 0 0 2 2 2 0 Geminivirus AL3 protein HHH PF00633.23 EEA28875.1 - 0.13 12.2 0.0 0.43 10.6 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif Sin_N PF04801.13 EEA28876.1 - 2.4e-23 83.1 0.0 5.1e-23 82.0 0.0 1.4 1 1 0 1 1 1 1 Sin-like protein conserved region NIR_SIR PF01077.22 EEA28877.1 - 2.6e-52 176.5 0.0 1.9e-45 154.2 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EEA28877.1 - 1.7e-30 104.7 0.0 2.2e-14 53.0 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 EEA28877.1 - 3.3e-26 92.2 0.0 6.6e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 EEA28877.1 - 1.2e-06 28.5 0.0 3e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Kei1 PF08552.11 EEA28878.1 - 5.4e-68 228.6 1.3 7.3e-68 228.2 1.3 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Ras PF00071.22 EEA28879.1 - 1.8e-59 200.0 0.3 2.3e-59 199.6 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA28879.1 - 3.6e-37 127.2 0.1 6e-37 126.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA28879.1 - 1.1e-17 64.0 0.2 1.4e-17 63.7 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EEA28879.1 - 7.4e-06 25.5 0.0 1e-05 25.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EEA28879.1 - 7.8e-06 25.6 0.1 4.9e-05 22.9 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EEA28879.1 - 1.6e-05 24.9 0.0 2.5e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EEA28879.1 - 5.1e-05 22.7 0.2 6.3e-05 22.4 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EEA28879.1 - 0.00011 22.2 0.1 0.096 12.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase TIR_2 PF13676.6 EEA28879.1 - 0.091 13.4 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 TIR domain AAA_7 PF12775.7 EEA28879.1 - 0.094 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP-synt_C PF00137.21 EEA28880.1 - 1.1e-22 80.2 36.0 2.4e-14 53.4 12.2 2.7 3 0 0 3 3 3 2 ATP synthase subunit C SLATT_5 PF18160.1 EEA28880.1 - 0.076 12.3 1.2 0.33 10.3 0.1 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Phage_holin_2_1 PF04971.12 EEA28880.1 - 0.22 11.6 0.3 0.22 11.6 0.3 2.3 2 1 0 2 2 2 0 Bacteriophage P21 holin S MoCF_biosynth PF00994.24 EEA28881.1 - 3.3e-48 163.0 0.0 1.7e-23 82.8 0.0 2.5 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EEA28881.1 - 1e-39 135.8 1.5 1.7e-39 135.1 1.5 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 EEA28881.1 - 1.4e-16 60.4 0.1 3e-16 59.3 0.1 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) SelP_N PF04592.14 EEA28881.1 - 1.8 7.9 14.8 2.8 7.3 14.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DDHD PF02862.17 EEA28882.1 - 3.2e-26 92.9 0.0 2.3e-23 83.6 0.0 2.9 2 1 0 2 2 2 1 DDHD domain Abhydrolase_6 PF12697.7 EEA28882.1 - 0.063 13.9 0.0 0.5 10.9 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family DDHD PF02862.17 EEA28883.1 - 0.00011 22.4 0.1 0.00059 20.1 0.0 2.0 2 0 0 2 2 2 1 DDHD domain Abhydrolase_6 PF12697.7 EEA28883.1 - 0.12 12.9 0.1 1.2 9.7 0.0 2.5 3 0 0 3 3 3 0 Alpha/beta hydrolase family FAD_binding_3 PF01494.19 EEA28885.1 - 3.3e-71 240.4 0.0 4.1e-71 240.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EEA28885.1 - 1e-35 123.3 0.0 1.7e-35 122.5 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.24 EEA28885.1 - 0.00035 20.2 0.0 0.03 13.9 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EEA28885.1 - 0.00099 18.4 0.0 0.038 13.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA28885.1 - 0.043 14.4 0.0 0.14 12.8 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA28885.1 - 0.067 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EEA28885.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF866 PF05907.13 EEA28886.1 - 6.4e-63 211.3 0.3 7.2e-63 211.1 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) HalOD2 PF18547.1 EEA28886.1 - 0.06 13.3 1.8 0.12 12.3 1.8 1.6 1 1 0 1 1 1 0 Halobacterial output domain 2 DUF4379 PF14311.6 EEA28886.1 - 0.095 13.1 0.6 0.095 13.1 0.6 2.3 1 1 1 2 2 2 0 Probable Zinc-ribbon domain zinc_ribbon_6 PF14599.6 EEA28886.1 - 0.1 12.7 2.2 7 6.7 0.0 2.7 2 1 1 3 3 3 0 Zinc-ribbon LSM PF01423.22 EEA28887.1 - 1.3e-19 69.6 0.0 1.5e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain Peptidase_U4 PF03419.13 EEA28888.1 - 0.071 12.4 0.5 0.59 9.4 0.0 2.1 2 0 0 2 2 2 0 Sporulation factor SpoIIGA SR-25 PF10500.9 EEA28889.1 - 0.067 12.8 23.1 0.086 12.4 23.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PAP1 PF08601.10 EEA28889.1 - 0.071 12.8 18.7 0.086 12.6 18.7 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 DUF4588 PF15251.6 EEA28889.1 - 0.087 12.6 10.5 0.1 12.3 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) Bul1_C PF04426.12 EEA28889.1 - 0.14 11.6 6.7 0.18 11.2 6.7 1.3 1 0 0 1 1 1 0 Bul1 C terminus SPX PF03105.19 EEA28889.1 - 0.29 11.0 15.9 0.34 10.8 15.9 1.0 1 0 0 1 1 1 0 SPX domain Sec62 PF03839.16 EEA28889.1 - 0.46 9.9 2.7 0.58 9.6 2.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 FAM220 PF15487.6 EEA28889.1 - 0.78 9.3 11.3 0.88 9.2 11.3 1.1 1 0 0 1 1 1 0 FAM220 family GREB1 PF15782.5 EEA28889.1 - 1.1 6.3 13.3 1.2 6.2 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Zip PF02535.22 EEA28889.1 - 1.8 7.7 3.9 1.9 7.7 3.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PI3K_1B_p101 PF10486.9 EEA28889.1 - 2.5 5.8 11.2 2.8 5.6 11.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Macoilin PF09726.9 EEA28889.1 - 3.3 6.1 14.6 3.8 6.0 14.6 1.0 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EEA28889.1 - 4.4 6.1 14.6 4.8 5.9 14.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain NST1 PF13945.6 EEA28889.1 - 4.5 7.3 12.4 5.7 7.0 12.4 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Lin-8 PF03353.15 EEA28889.1 - 4.7 6.7 11.2 5.4 6.5 11.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 EEA28889.1 - 5.5 5.6 9.6 6.3 5.4 9.6 1.1 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 EEA28890.1 - 0.055 13.1 23.1 0.07 12.7 23.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4588 PF15251.6 EEA28890.1 - 0.075 12.8 10.5 0.087 12.6 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) PAP1 PF08601.10 EEA28890.1 - 0.081 12.6 18.9 0.099 12.3 18.9 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 SPX PF03105.19 EEA28890.1 - 0.34 10.8 16.0 0.4 10.5 16.0 1.0 1 0 0 1 1 1 0 SPX domain Sec62 PF03839.16 EEA28890.1 - 0.61 9.5 3.2 0.75 9.3 3.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 EEA28890.1 - 1.5 7.9 3.9 1.5 8.0 3.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 EEA28890.1 - 2 6.7 7.3 2.2 6.5 7.3 1.1 1 0 0 1 1 1 0 Menin GREB1 PF15782.5 EEA28890.1 - 2.1 5.4 14.1 2.5 5.1 14.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PI3K_1B_p101 PF10486.9 EEA28890.1 - 2.5 5.8 10.6 2.9 5.6 10.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NST1 PF13945.6 EEA28890.1 - 2.7 8.1 11.9 3.3 7.8 11.9 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator FAM220 PF15487.6 EEA28890.1 - 3 7.4 13.0 3.4 7.2 13.0 1.1 1 0 0 1 1 1 0 FAM220 family Bul1_C PF04426.12 EEA28890.1 - 3.3 7.1 11.2 4.1 6.7 11.2 1.3 1 1 0 1 1 1 0 Bul1 C terminus Lin-8 PF03353.15 EEA28890.1 - 4.9 6.6 11.1 5.7 6.4 11.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 EEA28890.1 - 5.3 5.5 15.2 6.1 5.3 15.2 1.0 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EEA28890.1 - 6.6 5.4 10.1 7.5 5.2 10.1 1.0 1 0 0 1 1 1 0 Presenilin DASH_Dad1 PF08649.10 EEA28891.1 - 6.8e-25 87.0 3.4 9.6e-25 86.5 3.4 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad1 DUF913 PF06025.12 EEA28891.1 - 0.026 13.5 0.9 0.028 13.4 0.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4820 PF16091.5 EEA28891.1 - 0.041 13.2 2.0 0.046 13.1 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) FYDLN_acid PF09538.10 EEA28891.1 - 0.044 14.5 6.1 0.058 14.1 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) V_ATPase_I PF01496.19 EEA28891.1 - 0.056 11.4 4.8 0.064 11.2 4.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DASH_Dad2 PF08654.10 EEA28891.1 - 0.058 13.8 1.9 0.076 13.4 1.9 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad2 Astro_capsid_p PF12226.8 EEA28891.1 - 0.074 12.2 4.9 0.082 12.0 4.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2347 PF09804.9 EEA28891.1 - 0.091 12.3 0.5 0.11 12.1 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) MCU PF04678.13 EEA28891.1 - 0.12 12.4 0.8 0.15 12.2 0.8 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter ORC_WH_C PF18137.1 EEA28891.1 - 0.52 10.4 5.5 0.82 9.7 5.5 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF809 PF05663.11 EEA28891.1 - 3.6 7.7 4.9 6.1 7.0 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF809) PBP_sp32 PF07222.12 EEA28891.1 - 5.5 6.4 7.6 6.1 6.2 7.6 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Ras PF00071.22 EEA28892.1 - 7.8e-49 165.4 0.0 9.9e-49 165.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA28892.1 - 2.4e-20 72.9 0.0 3.9e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA28892.1 - 5.7e-05 22.6 0.0 0.00012 21.6 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EEA28892.1 - 0.024 14.2 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 EEA28892.1 - 0.092 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PAP2 PF01569.21 EEA28893.1 - 1.2e-18 67.2 3.4 4.5e-18 65.3 3.4 2.0 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EEA28893.1 - 0.00098 18.9 3.9 0.0025 17.5 3.9 1.8 1 0 0 1 1 1 1 PAP2 superfamily Peptidase_C48 PF02902.19 EEA28894.1 - 7.9e-26 91.2 0.0 1.5e-25 90.3 0.0 1.5 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain ABATE PF07336.11 EEA28894.1 - 0.65 10.7 15.3 0.08 13.6 5.2 3.7 3 0 0 3 3 3 0 Putative stress-induced transcription regulator Glyco_hydro_16 PF00722.21 EEA28895.1 - 0.0032 17.0 0.0 0.0081 15.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Spc7 PF08317.11 EEA28896.1 - 0.00068 18.6 4.6 0.0029 16.5 4.0 1.9 1 1 0 1 1 1 1 Spc7 kinetochore protein DUF1664 PF07889.12 EEA28896.1 - 0.00071 19.6 5.9 0.16 12.0 2.0 3.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) AAA_13 PF13166.6 EEA28896.1 - 0.0011 17.7 0.4 0.0015 17.3 0.4 1.1 1 0 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.9 EEA28896.1 - 0.0012 18.8 6.1 0.0018 18.3 1.9 2.8 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WEMBL PF05701.11 EEA28896.1 - 0.0013 17.5 0.9 0.0018 17.1 0.9 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light FlaC_arch PF05377.11 EEA28896.1 - 0.0031 17.9 4.7 0.69 10.3 0.1 3.9 3 1 1 4 4 2 1 Flagella accessory protein C (FlaC) ADIP PF11559.8 EEA28896.1 - 0.0037 17.4 4.8 0.0071 16.4 4.4 1.6 1 1 0 1 1 1 1 Afadin- and alpha -actinin-Binding BRE1 PF08647.11 EEA28896.1 - 0.0051 16.9 1.4 0.009 16.1 1.4 1.4 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase TACC_C PF05010.14 EEA28896.1 - 0.0069 16.2 1.0 0.011 15.5 1.0 1.3 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal KASH_CCD PF14662.6 EEA28896.1 - 0.0071 16.2 6.7 0.014 15.3 4.9 2.0 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH Prefoldin PF02996.17 EEA28896.1 - 0.0083 16.0 3.2 0.51 10.3 0.1 3.4 2 1 1 3 3 3 1 Prefoldin subunit DUF4618 PF15397.6 EEA28896.1 - 0.0098 15.3 5.7 0.52 9.7 0.6 2.6 1 1 0 2 2 2 1 Domain of unknown function (DUF4618) LPP PF04728.13 EEA28896.1 - 0.012 16.0 7.8 0.96 9.9 0.5 4.2 2 1 3 5 5 4 0 Lipoprotein leucine-zipper COG7 PF10191.9 EEA28896.1 - 0.012 13.9 3.0 0.39 8.9 1.6 2.1 1 1 1 2 2 2 0 Golgi complex component 7 (COG7) DUF2968 PF11180.8 EEA28896.1 - 0.012 15.2 3.7 0.027 14.1 3.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF2730 PF10805.8 EEA28896.1 - 0.014 15.5 2.1 2 8.6 0.3 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Seryl_tRNA_N PF02403.22 EEA28896.1 - 0.02 15.1 1.0 0.057 13.6 0.8 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 EEA28896.1 - 0.021 15.1 5.8 0.056 13.7 5.8 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) GAS PF13851.6 EEA28896.1 - 0.024 14.0 0.6 0.04 13.3 0.6 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 EEA28896.1 - 0.024 14.8 5.7 0.055 13.7 5.1 1.8 2 0 0 2 2 1 0 Fibrinogen alpha/beta chain family AIP3 PF03915.13 EEA28896.1 - 0.026 13.7 2.2 1.3 8.1 2.7 2.2 2 0 0 2 2 2 0 Actin interacting protein 3 MscS_porin PF12795.7 EEA28896.1 - 0.03 13.9 7.6 0.047 13.2 7.6 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF1640 PF07798.11 EEA28896.1 - 0.035 14.1 8.0 0.13 12.2 2.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) CCDC154 PF15450.6 EEA28896.1 - 0.038 12.5 5.5 0.05 12.1 3.1 1.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 154 HIP1_clath_bdg PF16515.5 EEA28896.1 - 0.039 14.6 2.6 0.84 10.3 0.8 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF641 PF04859.12 EEA28896.1 - 0.041 14.2 5.2 1.2 9.4 0.4 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4201 PF13870.6 EEA28896.1 - 0.042 13.6 1.9 0.08 12.7 0.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF4200 PF13863.6 EEA28896.1 - 0.042 14.2 0.7 0.19 12.1 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Baculo_PEP_C PF04513.12 EEA28896.1 - 0.044 13.8 10.9 0.25 11.4 8.9 2.7 3 1 0 3 3 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6_N PF17675.1 EEA28896.1 - 0.051 14.1 1.2 0.11 13.0 1.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region LURAP PF14854.6 EEA28896.1 - 0.061 13.3 0.7 0.21 11.5 0.3 2.1 2 1 1 3 3 1 0 Leucine rich adaptor protein BLOC1_2 PF10046.9 EEA28896.1 - 0.066 13.5 3.8 0.55 10.6 1.9 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SseC PF04888.12 EEA28896.1 - 0.068 12.8 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family bZIP_1 PF00170.21 EEA28896.1 - 0.07 13.2 1.5 1.1 9.4 0.1 2.9 2 1 0 3 3 2 0 bZIP transcription factor DUF724 PF05266.14 EEA28896.1 - 0.078 12.8 2.0 0.43 10.4 2.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Rootletin PF15035.6 EEA28896.1 - 0.087 12.8 3.7 0.3 11.1 3.7 1.8 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion YabA PF06156.13 EEA28896.1 - 0.1 13.2 3.2 0.71 10.6 1.4 2.7 1 1 1 2 2 2 0 Initiation control protein YabA DUF713 PF05218.14 EEA28896.1 - 0.14 11.9 0.4 0.59 9.8 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF713) Spc24 PF08286.11 EEA28896.1 - 0.14 12.4 2.8 8.3 6.7 0.4 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DivIC PF04977.15 EEA28896.1 - 0.17 11.6 8.0 15 5.4 0.3 3.4 2 1 1 3 3 3 0 Septum formation initiator DUF4763 PF15960.5 EEA28896.1 - 0.17 11.1 3.4 0.3 10.3 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Nup54 PF13874.6 EEA28896.1 - 0.18 11.9 4.3 0.44 10.7 4.3 1.7 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Fez1 PF06818.15 EEA28896.1 - 0.18 12.2 4.4 0.17 12.4 2.6 1.6 1 1 0 1 1 1 0 Fez1 Atg14 PF10186.9 EEA28896.1 - 0.18 10.8 3.6 0.17 11.0 2.0 1.7 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4795 PF16043.5 EEA28896.1 - 0.2 11.3 3.1 1.3 8.6 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Cnn_1N PF07989.11 EEA28896.1 - 0.23 11.7 2.1 4.1 7.6 2.1 2.6 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Mod_r PF07200.13 EEA28896.1 - 0.24 11.5 1.8 0.45 10.6 1.8 1.4 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein FliJ PF02050.16 EEA28896.1 - 0.28 11.4 4.0 37 4.6 1.4 3.0 2 1 1 3 3 3 0 Flagellar FliJ protein SlyX PF04102.12 EEA28896.1 - 0.28 11.8 7.0 0.38 11.4 3.4 2.7 2 1 0 2 2 2 0 SlyX YscO PF07321.12 EEA28896.1 - 0.29 11.1 4.0 0.74 9.8 2.6 2.1 1 1 1 2 2 2 0 Type III secretion protein YscO DUF5082 PF16888.5 EEA28896.1 - 0.33 11.2 4.2 11 6.3 4.3 3.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF948 PF06103.11 EEA28896.1 - 0.39 11.0 5.7 10 6.4 1.9 2.6 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 EEA28896.1 - 0.42 10.8 3.9 0.58 10.4 1.8 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding PspA_IM30 PF04012.12 EEA28896.1 - 0.44 10.1 4.9 5 6.6 4.9 2.2 1 1 0 1 1 1 0 PspA/IM30 family NPV_P10 PF05531.12 EEA28896.1 - 0.44 11.0 7.0 55 4.3 6.3 3.1 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein COG5 PF10392.9 EEA28896.1 - 0.47 10.6 3.8 4.8 7.4 0.2 3.1 2 1 1 3 3 3 0 Golgi transport complex subunit 5 Syntaxin_2 PF14523.6 EEA28896.1 - 0.52 10.7 4.5 1.7 9.1 4.5 1.9 1 1 0 1 1 1 0 Syntaxin-like protein WXG100 PF06013.12 EEA28896.1 - 0.59 10.4 2.0 1.1e+02 3.1 0.0 3.6 2 1 1 4 4 4 0 Proteins of 100 residues with WXG Laminin_II PF06009.12 EEA28896.1 - 0.61 10.1 4.9 1.7 8.6 2.9 2.5 2 1 1 3 3 2 0 Laminin Domain II DUF16 PF01519.16 EEA28896.1 - 1.3 9.6 5.9 12 6.4 5.9 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 FAM76 PF16046.5 EEA28896.1 - 1.8 7.8 3.6 24 4.1 0.1 2.1 1 1 1 2 2 2 0 FAM76 protein CLZ PF16526.5 EEA28896.1 - 1.9 8.9 4.6 14 6.1 0.8 3.4 1 1 3 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TolA_bind_tri PF16331.5 EEA28896.1 - 3.1 7.9 6.8 1.4e+02 2.6 5.3 3.3 2 1 0 2 2 1 0 TolA binding protein trimerisation GIT_CC PF16559.5 EEA28896.1 - 8.2 6.4 7.8 7.3 6.5 0.9 3.3 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf-HIT PF04438.16 EEA28897.1 - 1.3e-09 37.7 9.0 2.3e-09 37.0 9.0 1.4 1 0 0 1 1 1 1 HIT zinc finger PPP4R2 PF09184.11 EEA28897.1 - 0.033 13.8 7.2 0.058 13.0 7.2 1.5 1 0 0 1 1 1 0 PPP4R2 zf-MYND PF01753.18 EEA28897.1 - 0.81 9.8 7.1 1.8 8.7 7.1 1.6 1 0 0 1 1 1 0 MYND finger DUF3246 PF11596.8 EEA28897.1 - 1.1 8.6 9.1 2 7.8 9.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Cwf_Cwc_15 PF04889.12 EEA28897.1 - 6.5 6.4 17.8 0.4 10.4 12.6 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 EEA28897.1 - 6.6 4.7 24.9 9.2 4.2 24.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 EEA28897.1 - 7.2 5.6 19.8 12 4.9 19.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 EEA28897.1 - 8 4.5 20.6 12 4.0 20.6 1.1 1 0 0 1 1 1 0 Nop14-like family DUF442 PF04273.13 EEA28898.1 - 0.028 14.5 0.1 0.044 13.9 0.1 1.3 1 0 0 1 1 1 0 Putative phosphatase (DUF442) RRM_1 PF00076.22 EEA28899.1 - 7e-16 57.8 0.0 1.6e-15 56.6 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EEA28899.1 - 4.4e-06 27.1 0.7 4.4e-06 27.1 0.7 2.7 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 EEA28899.1 - 0.00013 21.7 0.0 0.00023 20.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EEA28899.1 - 0.17 12.0 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Snf7 PF03357.21 EEA28900.1 - 8.8e-21 74.3 14.8 1.7e-20 73.4 12.5 1.9 1 1 1 2 2 2 1 Snf7 Gon7 PF08738.10 EEA28900.1 - 0.011 15.8 4.4 0.032 14.3 2.3 2.3 2 0 0 2 2 2 0 Gon7 family BMFP PF04380.13 EEA28900.1 - 0.086 13.3 10.0 1.1 9.8 1.4 4.3 3 1 0 4 4 4 0 Membrane fusogenic activity TPR_MLP1_2 PF07926.12 EEA28900.1 - 1.7 8.7 19.7 0.051 13.6 9.0 2.9 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2408 PF10303.9 EEA28900.1 - 1.7 9.2 8.7 7.4 7.1 8.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) AAA_13 PF13166.6 EEA28900.1 - 3.1 6.3 11.3 6.3 5.3 11.2 1.5 1 1 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 EEA28900.1 - 4.5 7.4 15.7 4.9 7.3 9.1 2.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family GAS PF13851.6 EEA28900.1 - 4.9 6.5 14.7 0.99 8.7 7.7 2.4 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 EEA28900.1 - 5.5 7.4 14.9 2.6e+02 1.9 14.8 2.2 1 1 0 1 1 1 0 Fez1 DUF883 PF05957.13 EEA28900.1 - 6 7.5 10.7 17 6.1 5.4 3.1 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF883) WHIM1 PF15612.6 EEA28901.1 - 5.2e-07 29.0 0.1 1.6e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Nop14 PF04147.12 EEA28901.1 - 6.6 4.8 17.8 11 4.1 17.8 1.4 1 0 0 1 1 1 0 Nop14-like family DUF1770 PF08589.10 EEA28902.1 - 6.3e-30 104.1 1.5 9e-30 103.6 1.5 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) PfkB PF00294.24 EEA28903.1 - 6.4e-73 245.7 0.2 7.3e-73 245.5 0.2 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EEA28903.1 - 0.00036 20.0 0.0 0.00077 18.9 0.0 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF2700 PF10912.8 EEA28903.1 - 0.052 13.6 0.0 0.088 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2700) PfkB PF00294.24 EEA28904.1 - 8.4e-72 242.0 0.4 9.5e-72 241.8 0.4 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EEA28904.1 - 0.00036 20.0 0.0 0.00076 18.9 0.0 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF2700 PF10912.8 EEA28904.1 - 0.049 13.7 0.0 0.083 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2700) EST1_DNA_bind PF10373.9 EEA28905.1 - 2.5e-71 240.5 2.6 5e-71 239.5 0.3 2.3 2 1 1 3 3 3 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EEA28905.1 - 1.4e-20 74.3 0.3 2.4e-19 70.3 0.1 2.5 2 0 0 2 2 2 1 Telomerase activating protein Est1 zf-C2H2 PF00096.26 EEA28906.1 - 0.0031 17.9 16.1 0.016 15.6 0.4 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA28906.1 - 0.027 15.3 9.8 0.2 12.6 0.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EEA28906.1 - 0.052 13.6 1.9 0.11 12.5 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger DUF629 PF04780.12 EEA28906.1 - 1.4 7.3 4.6 1.1 7.7 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Fungal_trans PF04082.18 EEA28907.1 - 1.7e-13 50.2 0.5 1.7e-13 50.2 0.5 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EEA28907.1 - 2e-11 43.7 9.4 6.3e-05 23.2 3.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EEA28907.1 - 1.1e-08 35.1 12.1 5.7e-08 32.8 2.4 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EEA28907.1 - 3e-08 33.8 9.3 0.002 18.8 3.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA28907.1 - 5.4e-05 23.4 1.4 0.46 10.8 0.0 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EEA28907.1 - 0.0075 16.2 8.4 1 9.5 3.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HE PF16278.5 EEA28907.1 - 0.01 16.2 2.9 0.01 16.2 2.9 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 EEA28907.1 - 0.014 15.3 5.7 1.2 9.1 0.4 3.1 3 0 0 3 3 3 0 zinc-finger of a C2HC-type gag_pre-integrs PF13976.6 EEA28907.1 - 0.073 12.9 5.4 0.13 12.1 1.8 2.4 1 1 1 2 2 2 0 GAG-pre-integrase domain zf-met PF12874.7 EEA28907.1 - 0.12 12.8 3.4 8.9 6.9 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 EEA28907.1 - 0.42 10.3 2.5 0.48 10.1 0.0 2.2 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 EEA28907.1 - 2.3 8.3 6.2 5.3 7.2 2.7 2.4 1 1 1 2 2 2 0 BED zinc finger Pkinase PF00069.25 EEA28908.1 - 2.9e-69 233.4 0.0 7.2e-69 232.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA28908.1 - 4.9e-48 163.7 0.0 9.3e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EEA28908.1 - 5.9e-28 97.1 0.0 1.2e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_1 PF00536.30 EEA28908.1 - 1.9e-15 57.1 0.0 4.4e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EEA28908.1 - 3.3e-13 49.5 0.1 7.4e-13 48.4 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 EEA28908.1 - 3.7e-09 36.3 0.0 2.2e-05 23.9 0.0 2.5 2 0 0 2 2 2 2 Kinase-like RA PF00788.23 EEA28908.1 - 0.0012 19.5 0.0 0.002 18.7 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Pkinase_fungal PF17667.1 EEA28908.1 - 0.0021 16.9 0.0 0.0044 15.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EEA28908.1 - 0.041 13.2 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L5_C PF00673.21 EEA28909.1 - 1.9e-29 101.7 0.0 3e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EEA28909.1 - 0.00016 21.9 0.0 0.00029 21.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 MFS_1 PF07690.16 EEA28910.1 - 1.7e-24 86.5 23.1 1.7e-24 86.5 23.1 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28910.1 - 0.004 16.1 31.0 0.15 10.9 31.0 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter UCH PF00443.29 EEA28911.1 - 8.3e-16 58.2 0.0 1.9e-15 57.1 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA28911.1 - 6.3e-14 52.3 0.0 9.5e-06 25.4 0.0 2.4 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase EnY2 PF10163.9 EEA28911.1 - 0.052 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Transcription factor e(y)2 Pep3_Vps18 PF05131.14 EEA28912.1 - 5.3e-44 149.6 0.4 3.2e-43 147.1 0.0 2.4 3 0 0 3 3 3 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EEA28912.1 - 8.5e-09 35.4 10.0 2.7e-07 30.6 0.2 3.2 4 0 0 4 4 4 2 Region in Clathrin and VPS zf-RING_11 PF17123.5 EEA28912.1 - 0.00013 21.6 3.9 0.00027 20.6 3.9 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA28912.1 - 0.00048 19.9 0.7 0.001 18.8 0.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA28912.1 - 0.00056 20.2 0.8 0.0012 19.1 0.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EEA28912.1 - 0.00061 19.7 0.2 0.0012 18.7 0.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EEA28912.1 - 0.0012 18.4 0.1 0.0022 17.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type DUF2175 PF09943.9 EEA28912.1 - 0.0015 18.8 0.4 0.23 11.7 0.0 2.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_UBOX PF13445.6 EEA28912.1 - 0.0058 16.6 0.3 0.014 15.4 0.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Vps39_2 PF10367.9 EEA28912.1 - 0.0099 16.3 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-C3HC4 PF00097.25 EEA28912.1 - 0.053 13.4 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA28912.1 - 0.097 13.0 0.2 0.59 10.5 0.5 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.5 EEA28912.1 - 0.13 12.3 0.9 0.29 11.2 0.9 1.6 1 0 0 1 1 1 0 Zinc-finger Sugar_tr PF00083.24 EEA28913.1 - 3.3e-69 233.9 26.7 3.8e-69 233.7 26.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA28913.1 - 5.4e-08 32.1 42.9 9.8e-06 24.7 26.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EEA28913.1 - 0.00023 19.9 20.7 0.0013 17.4 3.2 2.5 2 1 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EEA28913.1 - 0.076 11.9 12.5 0.091 11.6 7.1 2.5 2 0 0 2 2 2 0 MFS_1 like family BAR PF03114.18 EEA28914.1 - 4.1e-48 164.1 10.1 5.7e-48 163.7 10.1 1.2 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 EEA28914.1 - 5.9e-05 22.3 3.6 9.4e-05 21.7 3.6 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Ribosomal_S10 PF00338.22 EEA28914.1 - 0.11 12.7 0.0 0.33 11.2 0.0 1.8 1 1 0 1 1 1 0 Ribosomal protein S10p/S20e APG6_N PF17675.1 EEA28914.1 - 0.24 11.9 10.1 0.37 11.3 9.4 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region OmpH PF03938.14 EEA28914.1 - 1.1 9.6 8.9 3.6 7.9 6.6 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) GBP_C PF02841.14 EEA28914.1 - 7.6 5.8 13.4 0.14 11.5 6.3 1.6 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain SNF2_N PF00176.23 EEA28915.1 - 3.6e-71 239.7 1.1 3.6e-71 239.7 1.1 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 EEA28915.1 - 1.5e-25 89.1 1.5 5.2e-25 87.3 1.3 2.1 1 1 1 2 2 2 1 Bromodomain Helicase_C PF00271.31 EEA28915.1 - 1.8e-20 73.3 0.7 9.5e-19 67.8 0.0 3.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EEA28915.1 - 3.5e-16 59.3 15.1 3.5e-16 59.3 15.1 4.1 4 1 1 5 5 5 1 HSA SnAC PF14619.6 EEA28915.1 - 3.8e-14 53.1 4.0 3.8e-14 53.1 4.0 4.3 5 0 0 5 5 5 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 EEA28915.1 - 1.5e-10 40.6 3.5 1.5e-10 40.6 3.5 2.4 2 0 0 2 2 2 1 QLQ ResIII PF04851.15 EEA28915.1 - 3.9e-10 40.0 0.0 3.9e-10 40.0 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Alpha-amylase PF00128.24 EEA28916.1 - 3.9e-17 62.8 0.1 1.9e-16 60.6 0.1 2.0 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 EEA28916.1 - 3.1e-12 46.7 0.2 5.5e-12 45.9 0.2 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EEA28916.1 - 4.8e-06 26.2 0.0 9.1e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EEA28916.1 - 0.0069 16.8 0.0 0.018 15.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EEA28916.1 - 0.012 15.6 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Spt20 PF12090.8 EEA28916.1 - 0.13 11.9 0.3 0.25 10.9 0.0 1.6 2 0 0 2 2 2 0 Spt20 family Flavodoxin_1 PF00258.25 EEA28917.1 - 2.7e-32 111.9 0.0 4.5e-32 111.2 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EEA28917.1 - 2e-30 106.0 0.0 3.1e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EEA28917.1 - 3.3e-12 47.0 0.0 1.3e-11 45.1 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.7 EEA28917.1 - 0.0035 17.0 0.0 0.046 13.4 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin domain Flavodoxin_5 PF12724.7 EEA28917.1 - 0.009 16.3 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin domain RNA_pol_3_Rpc31 PF11705.8 EEA28918.1 - 6.1e-59 200.0 19.2 7.3e-59 199.8 19.2 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 EEA28918.1 - 0.72 9.1 12.0 0.76 9.0 12.0 1.2 1 0 0 1 1 1 0 BUD22 SURF2 PF05477.11 EEA28918.1 - 1.1 9.0 6.0 1.8 8.2 6.0 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RNA_pol_3_Rpc31 PF11705.8 EEA28919.1 - 3.8e-49 168.0 18.9 4.6e-49 167.7 18.9 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 EEA28919.1 - 0.66 9.3 12.0 0.7 9.2 12.0 1.2 1 0 0 1 1 1 0 BUD22 SURF2 PF05477.11 EEA28919.1 - 0.97 9.1 6.0 1.7 8.3 6.0 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Peripla_BP_3 PF13377.6 EEA28920.1 - 0.021 15.1 0.4 0.051 13.9 0.4 1.6 1 0 0 1 1 1 0 Periplasmic binding protein-like domain MitMem_reg PF13012.6 EEA28921.1 - 3.3e-09 37.2 0.1 6.6e-09 36.2 0.1 1.6 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EEA28921.1 - 2.2e-08 34.1 0.0 3.6e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Solute_trans_a PF03619.16 EEA28922.1 - 3.8e-88 295.5 19.7 4.5e-88 295.2 19.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha RTA1 PF04479.13 EEA28923.1 - 8.7e-59 198.6 15.3 8.7e-59 198.6 15.3 1.9 2 0 0 2 2 2 1 RTA1 like protein Fungal_trans_2 PF11951.8 EEA28924.1 - 0.043 12.6 0.3 0.068 12.0 0.3 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain RSB_motif PF16294.5 EEA28925.1 - 5.6e-17 61.9 0.3 5.6e-17 61.9 0.3 3.7 3 1 1 4 4 4 1 RNSP1-SAP18 binding (RSB) motif SAP PF02037.27 EEA28925.1 - 7.3e-08 32.0 0.3 1.3e-07 31.2 0.3 1.4 1 0 0 1 1 1 1 SAP domain Pinin_SDK_memA PF04696.13 EEA28925.1 - 0.24 11.4 0.0 0.24 11.4 0.0 3.0 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region ADH_zinc_N PF00107.26 EEA28926.1 - 1.5e-09 37.9 0.0 3.7e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EEA28926.1 - 1.3e-06 28.3 0.0 1.1e-05 25.3 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF1993 PF09351.10 EEA28927.1 - 1.9e-47 161.4 0.0 2.2e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) Abhydrolase_1 PF00561.20 EEA28929.1 - 1.9e-50 171.9 0.0 3e-50 171.2 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA28929.1 - 0.00062 20.4 6.2 0.0016 19.1 6.2 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family PEP_hydrolase PF09370.10 EEA28929.1 - 0.15 11.2 0.0 0.41 9.8 0.0 1.6 2 0 0 2 2 2 0 Phosphoenolpyruvate hydrolase-like THOC2_N PF16134.5 EEA28930.1 - 2.6e-235 782.9 0.0 3.7e-235 782.4 0.0 1.2 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EEA28930.1 - 7.1e-106 353.8 0.2 1.2e-105 353.0 0.2 1.4 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EEA28930.1 - 1.3e-29 102.1 0.1 2.8e-28 97.8 0.0 2.5 2 0 0 2 2 2 1 Transcription- and export-related complex subunit PAM2 PF07145.15 EEA28930.1 - 0.16 11.7 2.1 0.29 10.9 0.2 2.5 2 0 0 2 2 2 0 Ataxin-2 C-terminal region LZ_Tnp_IS66 PF13007.7 EEA28931.1 - 0.23 12.2 5.4 4.2 8.2 1.7 3.2 3 0 0 3 3 3 0 Transposase C of IS166 homeodomain DUF2190 PF09956.9 EEA28931.1 - 2.4 8.7 6.5 0.47 11.0 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2190) Ctr PF04145.15 EEA28932.1 - 1.2e-40 139.5 1.4 1.7e-40 139.0 1.4 1.2 1 0 0 1 1 1 1 Ctr copper transporter family DUF4719 PF15843.5 EEA28932.1 - 1.1 9.3 7.5 1 9.4 0.4 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4719) Oxidored_q3 PF00499.20 EEA28932.1 - 1.8 8.3 9.6 8.4 6.1 8.9 2.0 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Ctr PF04145.15 EEA28933.1 - 1.3e-40 139.4 1.4 1.8e-40 138.9 1.4 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Oxidored_q3 PF00499.20 EEA28933.1 - 0.26 11.0 7.0 1.1 8.9 6.3 1.9 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4719 PF15843.5 EEA28933.1 - 1.8 8.6 8.1 1.1 9.3 0.5 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4719) Ctr PF04145.15 EEA28934.1 - 1.3e-40 139.4 1.4 1.8e-40 138.9 1.4 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Oxidored_q3 PF00499.20 EEA28934.1 - 0.26 11.0 7.0 1.1 8.9 6.3 1.9 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4719 PF15843.5 EEA28934.1 - 1.8 8.6 8.1 1.1 9.3 0.5 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4719) MFS_1 PF07690.16 EEA28935.1 - 1.6e-28 99.7 34.5 1.6e-28 99.7 34.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4231 PF14015.6 EEA28936.1 - 0.22 12.0 1.0 0.55 10.7 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Colicin_V PF02674.16 EEA28936.1 - 0.33 10.9 4.7 0.088 12.8 0.9 1.8 1 1 1 2 2 2 0 Colicin V production protein VCBS PF13517.6 EEA28937.1 - 2.1e-29 101.9 49.1 1.2e-12 48.2 5.0 7.7 3 2 5 8 8 8 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Lipase_GDSL_2 PF13472.6 EEA28937.1 - 2.8e-16 60.4 4.0 2e-15 57.6 1.1 2.5 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EEA28937.1 - 1.9e-09 37.8 0.2 5.5e-09 36.3 0.2 1.7 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase TcdB_toxin_midN PF12256.8 EEA28937.1 - 6.5e-09 35.4 8.7 0.32 10.3 0.0 7.2 4 3 4 8 8 8 3 Insecticide toxin TcdB middle/N-terminal region Lipase_GDSL_3 PF14606.6 EEA28937.1 - 0.0048 17.0 0.3 0.012 15.7 0.3 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family FG-GAP PF01839.23 EEA28937.1 - 0.07 13.3 35.6 0.44 10.7 2.0 6.7 6 1 1 7 7 7 0 FG-GAP repeat EF-hand_1 PF00036.32 EEA28937.1 - 1.5 8.5 13.7 9.2 6.1 0.1 4.5 5 0 0 5 5 5 0 EF hand Fungal_trans PF04082.18 EEA28938.1 - 6.8e-14 51.5 0.9 9.9e-14 51.0 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA28938.1 - 1.5e-08 34.6 9.9 2.6e-08 33.9 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cwf_Cwc_15 PF04889.12 EEA28938.1 - 0.0051 16.6 1.4 0.0076 16.0 1.4 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Dickkopf_N PF04706.12 EEA28938.1 - 0.15 12.5 5.9 0.31 11.6 5.9 1.4 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Mtp PF03821.16 EEA28938.1 - 0.31 10.6 1.0 0.59 9.7 0.5 1.7 2 0 0 2 2 2 0 Golgi 4-transmembrane spanning transporter PBP1_TM PF14812.6 EEA28938.1 - 1.4 9.4 8.7 4.3 7.8 8.7 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MFS_1 PF07690.16 EEA28939.1 - 8.8e-44 149.9 44.2 3.1e-43 148.0 44.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28939.1 - 6.4e-07 28.6 14.7 6.4e-07 28.6 14.7 3.4 2 2 1 4 4 4 2 Sugar (and other) transporter Vps5 PF09325.10 EEA28941.1 - 5.2e-14 52.4 0.1 8.3e-14 51.7 0.1 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EEA28941.1 - 8.1e-08 32.2 0.0 1.6e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 PX domain TPR_12 PF13424.6 EEA28941.1 - 0.038 14.3 0.5 0.22 11.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat GTP_EFTU PF00009.27 EEA28942.1 - 2.3e-55 187.2 0.0 3.8e-55 186.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EEA28942.1 - 2.7e-27 94.7 0.0 6.6e-27 93.4 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EEA28942.1 - 6.8e-16 58.1 0.1 8.7e-09 35.3 0.0 2.4 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EEA28942.1 - 1.1e-07 32.1 0.0 3.8e-07 30.4 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EEA28942.1 - 1.7e-05 24.7 0.0 3.5e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_IV PF03764.18 EEA28942.1 - 0.00023 20.9 0.1 0.0063 16.3 0.0 2.7 3 0 0 3 3 3 1 Elongation factor G, domain IV ArfGap PF01412.18 EEA28943.1 - 5.2e-32 110.4 0.1 8.6e-32 109.7 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf RRM_1 PF00076.22 EEA28944.1 - 2.3e-30 104.2 0.2 1.8e-14 53.3 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA28944.1 - 0.00021 20.9 0.0 0.38 10.4 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA28944.1 - 0.00024 21.2 0.0 0.065 13.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 EEA28944.1 - 0.0045 17.2 0.2 4 7.6 0.0 3.0 2 2 2 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 EEA28944.1 - 0.0079 16.0 0.1 1.3 8.9 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif RNA_pol_3_Rpc31 PF11705.8 EEA28944.1 - 0.008 16.5 0.9 0.013 15.7 0.9 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 FXMRP1_C_core PF12235.8 EEA28944.1 - 0.075 13.7 7.9 0.16 12.6 7.9 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal RRM_Rrp7 PF17799.1 EEA28944.1 - 0.1 12.4 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain DUF2985 PF11204.8 EEA28945.1 - 4.1e-22 78.1 4.0 7.2e-22 77.3 4.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) DHR10 PF18595.1 EEA28946.1 - 0.011 15.8 3.5 0.011 15.8 3.5 2.9 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Fib_alpha PF08702.10 EEA28946.1 - 0.026 14.7 2.9 0.054 13.7 2.9 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Med30 PF11315.8 EEA28946.1 - 0.069 13.3 1.8 0.29 11.3 0.0 2.4 2 0 0 2 2 2 0 Mediator complex subunit 30 PI_PP_I PF18363.1 EEA28946.1 - 0.16 12.2 0.5 4.2 7.6 0.2 2.7 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain YabA PF06156.13 EEA28946.1 - 1.2 9.8 7.7 2 9.1 0.6 2.7 2 0 0 2 2 2 0 Initiation control protein YabA YkyA PF10368.9 EEA28946.1 - 2.4 7.8 7.0 0.49 10.1 1.8 2.2 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein GAS PF13851.6 EEA28946.1 - 4.9 6.5 13.8 1.6 8.1 1.6 2.8 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding Muted PF14942.6 EEA28946.1 - 8.4 6.7 10.3 50 4.2 10.3 2.1 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein VASt PF16016.5 EEA28947.1 - 1e-34 120.2 0.0 2.1e-34 119.2 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EEA28947.1 - 6.2e-22 77.6 0.0 1.1e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Glyco_hydro_3 PF00933.21 EEA28948.1 - 9.2e-59 199.4 0.0 1.3e-58 198.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EEA28948.1 - 6.6e-52 176.4 0.0 1.1e-51 175.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EEA28948.1 - 6.8e-22 77.4 2.8 7e-21 74.1 0.5 2.5 2 0 0 2 2 2 1 Fibronectin type III-like domain Sugar-bind PF04198.13 EEA28948.1 - 0.029 13.5 0.1 0.051 12.7 0.1 1.3 1 0 0 1 1 1 0 Putative sugar-binding domain p450 PF00067.22 EEA28949.1 - 5.7e-38 130.8 0.0 7.6e-38 130.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Clusterin PF01093.17 EEA28949.1 - 0.014 14.4 0.2 0.022 13.8 0.2 1.2 1 0 0 1 1 1 0 Clusterin Cut12 PF11500.8 EEA28949.1 - 0.049 13.6 0.1 0.095 12.6 0.1 1.4 1 0 0 1 1 1 0 Spindle pole body formation-associated protein DUF2390 PF09523.10 EEA28949.1 - 0.072 13.4 0.9 0.45 10.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) Terpene_synth_C PF03936.16 EEA28950.1 - 0.0013 18.2 0.4 0.0021 17.5 0.2 1.4 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain polyprenyl_synt PF00348.17 EEA28951.1 - 5.7e-45 153.4 0.0 7.2e-45 153.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Glyco_hydro_12 PF01670.16 EEA28952.1 - 2.1e-41 142.3 8.0 2.4e-41 142.1 8.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Phage_holin_5_1 PF06946.11 EEA28952.1 - 0.034 14.5 0.5 0.076 13.4 0.5 1.5 1 0 0 1 1 1 0 Bacteriophage A118-like holin, Hol118 Mg_trans_NIPA PF05653.14 EEA28953.1 - 9.2e-61 205.5 13.1 4.3e-58 196.8 7.4 2.5 3 0 0 3 3 3 2 Magnesium transporter NIPA EamA PF00892.20 EEA28953.1 - 0.00018 21.7 2.6 0.00018 21.7 2.6 3.6 3 1 0 3 3 3 1 EamA-like transporter family DUF3040 PF11239.8 EEA28953.1 - 0.15 12.4 1.4 41 4.5 0.2 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) WD40 PF00400.32 EEA28954.1 - 8.6e-16 58.1 12.3 0.00052 20.8 0.4 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28954.1 - 2.8e-05 24.3 0.0 0.18 12.1 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain VID27_N PF17748.1 EEA28954.1 - 0.0091 15.9 1.6 0.021 14.7 1.6 1.6 1 0 0 1 1 1 1 VID27 N-terminal region eIF2A PF08662.11 EEA28954.1 - 0.098 12.5 0.1 1.5 8.7 0.0 2.7 3 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A CENP-B_dimeris PF09026.10 EEA28954.1 - 0.19 12.1 16.3 0.37 11.2 16.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GCIP PF13324.6 EEA28954.1 - 0.35 10.4 2.6 0.51 9.9 2.6 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 EEA28954.1 - 0.74 9.1 14.7 1.1 8.5 14.7 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 EEA28954.1 - 0.94 9.2 19.9 0.046 13.5 13.0 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 EEA28954.1 - 1.1 8.9 3.5 3.1 7.5 3.5 1.7 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 EEA28954.1 - 7.7 6.5 7.2 16 5.5 7.2 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 EEA28954.1 - 8 4.4 15.7 11 4.0 15.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cyclin_C_2 PF16899.5 EEA28955.1 - 1.4e-37 128.2 0.5 3.9e-34 117.2 0.0 2.6 3 0 0 3 3 3 2 Cyclin C-terminal domain Cyclin_N PF00134.23 EEA28955.1 - 6e-06 26.0 0.0 2.2e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain UQ_con PF00179.26 EEA28956.1 - 3.2e-43 146.7 0.0 4e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EEA28956.1 - 2.8e-05 23.8 0.0 5.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EEA28956.1 - 0.058 13.1 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B DUF2095 PF09868.9 EEA28956.1 - 0.064 13.2 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) RWD PF05773.22 EEA28956.1 - 0.088 13.1 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 RWD domain UQ_con PF00179.26 EEA28957.1 - 3.2e-43 146.7 0.0 4e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EEA28957.1 - 2.8e-05 23.8 0.0 5.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EEA28957.1 - 0.058 13.1 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B DUF2095 PF09868.9 EEA28957.1 - 0.064 13.2 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) RWD PF05773.22 EEA28957.1 - 0.088 13.1 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 RWD domain UQ_con PF00179.26 EEA28958.1 - 3.2e-43 146.7 0.0 4e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EEA28958.1 - 2.8e-05 23.8 0.0 5.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EEA28958.1 - 0.058 13.1 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B DUF2095 PF09868.9 EEA28958.1 - 0.064 13.2 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) RWD PF05773.22 EEA28958.1 - 0.088 13.1 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 RWD domain UQ_con PF00179.26 EEA28959.1 - 3.2e-43 146.7 0.0 4e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EEA28959.1 - 2.8e-05 23.8 0.0 5.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EEA28959.1 - 0.058 13.1 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B DUF2095 PF09868.9 EEA28959.1 - 0.064 13.2 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) RWD PF05773.22 EEA28959.1 - 0.088 13.1 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 RWD domain AAA PF00004.29 EEA28960.1 - 9.9e-41 139.3 0.0 1.9e-40 138.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA28960.1 - 2.2e-11 43.4 0.3 4.8e-11 42.3 0.3 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EEA28960.1 - 1.3e-09 37.8 0.1 2.7e-09 36.8 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EEA28960.1 - 8.6e-06 25.8 0.0 2.5e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA28960.1 - 9.2e-06 25.9 0.0 1.9e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA28960.1 - 1.7e-05 25.1 0.2 0.029 14.6 0.1 2.5 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 EEA28960.1 - 1.9e-05 23.9 0.0 3.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EEA28960.1 - 0.00051 20.5 0.2 0.01 16.2 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EEA28960.1 - 0.00059 19.6 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 EEA28960.1 - 0.0098 15.8 0.0 0.052 13.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EEA28960.1 - 0.011 16.0 0.2 0.038 14.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA28960.1 - 0.015 15.0 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EEA28960.1 - 0.016 14.4 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_33 PF13671.6 EEA28960.1 - 0.02 15.1 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA28960.1 - 0.026 15.1 0.0 0.092 13.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EEA28960.1 - 0.028 14.3 0.1 0.82 9.6 0.1 2.8 2 1 1 3 3 3 0 NACHT domain PhoH PF02562.16 EEA28960.1 - 0.029 13.8 0.3 0.29 10.5 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 EEA28960.1 - 0.032 13.6 0.1 0.37 10.1 0.1 2.2 1 1 0 2 2 2 0 KaiC Zeta_toxin PF06414.12 EEA28960.1 - 0.042 13.1 0.1 0.097 11.9 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.21 EEA28960.1 - 0.044 13.2 0.1 0.097 12.0 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA28960.1 - 0.062 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 EEA28960.1 - 0.087 12.7 0.5 0.7 9.8 0.0 2.5 3 0 0 3 3 3 0 NTPase AAA_14 PF13173.6 EEA28960.1 - 0.088 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EEA28960.1 - 0.13 11.9 1.2 0.26 11.0 0.3 2.0 2 1 0 2 2 2 0 AAA domain Prot_ATP_OB_N PF17758.1 EEA28960.1 - 0.16 11.7 0.7 0.7 9.6 0.0 2.3 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain AAA_7 PF12775.7 EEA28960.1 - 0.17 11.4 0.1 0.39 10.2 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EEA28960.1 - 1.6 8.2 4.8 1.4 8.4 0.3 2.8 2 1 1 3 3 3 0 AAA domain ABC_tran PF00005.27 EEA28961.1 - 6.7e-46 156.2 0.0 1.5e-22 80.6 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EEA28961.1 - 1.2e-20 73.3 1.3 1.2e-20 73.3 1.3 3.3 5 0 0 5 5 2 1 ABC transporter AAA_21 PF13304.6 EEA28961.1 - 1.9e-18 67.3 0.6 0.0009 19.1 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA28961.1 - 4.1e-11 42.7 0.1 0.0049 16.3 0.1 4.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EEA28961.1 - 1.9e-09 38.3 3.3 0.0073 16.8 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_29 PF13555.6 EEA28961.1 - 4.9e-09 35.8 0.0 0.0024 17.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EEA28961.1 - 5.4e-07 29.6 0.0 0.033 13.9 0.0 2.7 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA28961.1 - 1.9e-06 27.9 0.0 0.0038 17.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EEA28961.1 - 3e-06 27.8 0.1 0.021 15.4 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 EEA28961.1 - 4.2e-06 27.3 0.0 0.0088 16.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA28961.1 - 1.7e-05 25.1 0.0 0.067 13.5 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_27 PF13514.6 EEA28961.1 - 1.9e-05 24.4 0.0 0.008 15.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EEA28961.1 - 2.2e-05 24.5 0.0 0.026 14.6 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EEA28961.1 - 0.00013 22.2 0.0 0.049 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EEA28961.1 - 0.00024 21.5 0.0 0.82 10.1 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EEA28961.1 - 0.00032 20.7 0.1 0.68 9.8 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_5 PF07728.14 EEA28961.1 - 0.00035 20.6 0.1 0.8 9.7 0.1 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EEA28961.1 - 0.00047 20.5 0.3 2.1 8.8 0.0 3.2 3 0 0 3 3 3 2 RNA helicase AAA_33 PF13671.6 EEA28961.1 - 0.0009 19.4 0.5 0.67 10.1 0.0 3.4 4 0 0 4 4 3 1 AAA domain AAA_24 PF13479.6 EEA28961.1 - 0.0011 18.8 0.4 1.9 8.2 0.0 3.6 4 0 0 4 4 4 1 AAA domain NB-ARC PF00931.22 EEA28961.1 - 0.0025 17.1 0.0 2.7 7.1 0.0 3.1 3 0 0 3 3 3 1 NB-ARC domain Roc PF08477.13 EEA28961.1 - 0.0025 18.0 0.0 2.9 8.1 0.0 3.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EEA28961.1 - 0.0067 16.5 0.0 1.5 8.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF2813 PF11398.8 EEA28961.1 - 0.0096 15.2 1.0 2.2 7.5 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2813) AAA_7 PF12775.7 EEA28961.1 - 0.013 15.0 0.1 0.92 9.0 0.0 2.8 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_25 PF13481.6 EEA28961.1 - 0.021 14.4 0.0 0.9 9.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain GST_C_3 PF14497.6 EEA28961.1 - 0.022 14.9 0.2 0.06 13.5 0.2 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AAA_30 PF13604.6 EEA28961.1 - 0.027 14.2 0.6 2.7 7.7 0.0 3.3 4 1 0 4 4 3 0 AAA domain MCM PF00493.23 EEA28961.1 - 0.03 13.4 0.0 2.2 7.3 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain DUF815 PF05673.13 EEA28961.1 - 0.039 13.1 0.0 2.6 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DAP3 PF10236.9 EEA28961.1 - 0.052 12.7 0.1 4.6 6.3 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_17 PF13207.6 EEA28961.1 - 0.059 13.8 0.0 11 6.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EEA28961.1 - 0.066 13.3 1.9 27 4.8 0.0 3.7 2 1 1 3 3 3 0 Dynamin family ATPase_2 PF01637.18 EEA28961.1 - 0.07 13.0 0.0 12 5.8 0.0 2.7 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea DUF87 PF01935.17 EEA28961.1 - 0.082 13.0 0.4 16 5.5 0.0 3.0 3 0 0 3 3 2 0 Helicase HerA, central domain NTPase_1 PF03266.15 EEA28961.1 - 0.093 12.6 0.1 3.9 7.4 0.1 2.5 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 EEA28961.1 - 0.13 12.0 0.4 5.6 6.7 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EEA28961.1 - 0.22 11.0 0.3 16 5.0 0.1 2.9 3 0 0 3 3 3 0 Ferrous iron transport protein B G-alpha PF00503.20 EEA28961.1 - 0.27 10.3 1.1 3 6.9 0.0 2.7 3 1 1 4 4 4 0 G-protein alpha subunit HPP PF04982.13 EEA28962.1 - 1.5e-38 131.7 9.8 1.5e-38 131.7 9.8 1.5 2 0 0 2 2 2 1 HPP family GFO_IDH_MocA PF01408.22 EEA28963.1 - 4.1e-24 85.7 0.0 7e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EEA28963.1 - 7.8e-12 45.2 0.0 1.2e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding PF02629.19 EEA28963.1 - 2.4e-05 24.9 0.1 6.1e-05 23.6 0.1 1.7 1 1 0 1 1 1 1 CoA binding domain NAD_binding_3 PF03447.16 EEA28963.1 - 6.2e-05 23.6 0.0 0.00013 22.6 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 EEA28963.1 - 0.0018 18.4 0.0 0.0031 17.6 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus DUF4350 PF14258.6 EEA28963.1 - 0.0041 17.5 0.0 0.11 13.0 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4350) CoA_binding_2 PF13380.6 EEA28963.1 - 0.016 15.7 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 CoA binding domain OCD_Mu_crystall PF02423.15 EEA28963.1 - 0.026 13.4 0.0 0.043 12.7 0.0 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Sacchrp_dh_NADP PF03435.18 EEA28963.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GFO_IDH_MocA PF01408.22 EEA28964.1 - 3.5e-24 85.9 0.0 5.2e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EEA28964.1 - 6e-12 45.6 0.0 9.4e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding PF02629.19 EEA28964.1 - 1.8e-05 25.3 0.1 4.8e-05 24.0 0.1 1.7 1 1 0 1 1 1 1 CoA binding domain NAD_binding_3 PF03447.16 EEA28964.1 - 4.9e-05 24.0 0.0 9.7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 EEA28964.1 - 0.0014 18.7 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus DUF4350 PF14258.6 EEA28964.1 - 0.003 17.9 0.0 0.085 13.3 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4350) CoA_binding_2 PF13380.6 EEA28964.1 - 0.015 15.7 0.1 0.025 15.1 0.1 1.3 1 0 0 1 1 1 0 CoA binding domain OCD_Mu_crystall PF02423.15 EEA28964.1 - 0.021 13.8 0.0 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Sacchrp_dh_NADP PF03435.18 EEA28964.1 - 0.086 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain potato_inhibit PF00280.18 EEA28965.1 - 0.12 13.0 0.4 15 6.4 0.0 2.5 2 0 0 2 2 2 0 Potato inhibitor I family MARVEL PF01284.23 EEA28967.1 - 3.5e-09 36.8 8.8 5.4e-09 36.2 8.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain CbtA PF09490.10 EEA28967.1 - 0.0043 16.8 0.4 0.59 9.9 0.2 2.3 1 1 1 2 2 2 2 Probable cobalt transporter subunit (CbtA) Peptidase_M56 PF05569.11 EEA28967.1 - 0.06 12.5 0.1 0.12 11.6 0.1 1.5 1 1 0 1 1 1 0 BlaR1 peptidase M56 DUF3262 PF11660.8 EEA28967.1 - 0.45 10.9 7.4 12 6.4 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3262) TPR_2 PF07719.17 EEA28968.1 - 2e-05 24.3 1.6 1.2 9.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA28968.1 - 0.0011 19.5 0.8 2.4 8.9 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA28968.1 - 0.0012 18.6 0.4 7.6 6.5 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA28968.1 - 0.0029 17.5 0.1 4 7.7 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA28968.1 - 0.011 16.0 0.4 2.1 8.7 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EEA28968.1 - 0.061 13.8 0.2 2.6 8.6 0.0 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EEA28968.1 - 0.42 10.6 2.8 4.7 7.2 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Cu_amine_oxid PF01179.20 EEA28969.1 - 8.9e-161 535.4 0.0 1.1e-160 535.1 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EEA28969.1 - 5.9e-21 74.8 0.3 4.4e-20 72.0 0.0 2.2 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EEA28969.1 - 5.8e-11 42.5 0.0 1.1e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Abhydrolase_6 PF12697.7 EEA28970.1 - 2.4e-13 51.2 0.0 3.2e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA28970.1 - 7.2e-09 35.7 0.1 3e-08 33.6 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA28970.1 - 3.5e-08 33.0 0.0 4.4e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EEA28970.1 - 0.0045 16.9 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase Thioesterase PF00975.20 EEA28970.1 - 0.0096 16.1 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.7 EEA28970.1 - 0.022 14.5 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 EEA28970.1 - 0.057 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_8 PF06259.12 EEA28970.1 - 0.076 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Palm_thioest PF02089.15 EEA28970.1 - 0.17 11.7 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase CAF1 PF04857.20 EEA28971.1 - 4.1e-22 78.8 0.0 1.1e-10 41.3 0.0 2.6 3 0 0 3 3 3 2 CAF1 family ribonuclease NDUF_B12 PF08122.12 EEA28972.1 - 9.4e-26 89.6 1.3 1.3e-25 89.1 1.3 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family WD40 PF00400.32 EEA28973.1 - 1.5e-18 66.8 9.4 0.0017 19.2 0.0 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA28973.1 - 9.4e-05 22.6 0.0 0.12 12.7 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA28973.1 - 0.39 9.6 2.1 2.8 6.8 0.1 3.1 4 1 0 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein AMP-binding PF00501.28 EEA28974.1 - 1.5e-75 254.4 0.0 2e-75 254.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA28974.1 - 1.1e-14 55.1 0.7 4.4e-14 53.2 0.4 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RVT_2 PF07727.14 EEA28976.1 - 1.9e-12 47.4 0.0 3.2e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EEA28976.1 - 1.3e-07 31.8 0.1 4.9e-07 29.9 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EEA28976.1 - 9.2e-05 22.2 1.0 0.0003 20.6 1.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain 2OG-FeII_Oxy_2 PF13532.6 EEA28977.1 - 2.3e-23 83.4 0.1 9.9e-23 81.3 0.1 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SHOCT PF09851.9 EEA28977.1 - 0.026 14.2 1.4 0.059 13.1 1.4 1.7 1 0 0 1 1 1 0 Short C-terminal domain CNH PF00780.22 EEA28978.1 - 3.2e-62 210.7 0.0 5.1e-62 210.0 0.0 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EEA28978.1 - 1.6e-33 116.4 1.2 2.7e-33 115.7 1.2 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 EEA28978.1 - 1.6e-12 47.7 0.0 5.6e-12 45.9 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EEA28978.1 - 0.0038 17.7 0.0 0.018 15.6 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_16 PF17838.1 EEA28978.1 - 0.064 13.1 0.1 6.7 6.6 0.0 2.4 2 0 0 2 2 2 0 PH domain PH_13 PF16652.5 EEA28978.1 - 0.078 12.8 0.3 0.59 9.9 0.0 2.5 3 0 0 3 3 3 0 Pleckstrin homology domain adh_short_C2 PF13561.6 EEA28979.1 - 4.2e-37 127.9 0.8 1.5e-35 122.9 0.8 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EEA28979.1 - 1.2e-27 96.6 1.9 5.1e-27 94.6 1.9 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EEA28979.1 - 2.2e-06 27.7 1.4 2.3e-06 27.6 0.2 1.5 2 0 0 2 2 2 1 KR domain His_biosynth PF00977.21 EEA28979.1 - 0.14 11.6 0.9 1.2 8.6 0.5 2.1 1 1 1 2 2 2 0 Histidine biosynthesis protein RabGAP-TBC PF00566.18 EEA28981.1 - 3.3e-46 157.7 0.0 5.2e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 EEA28981.1 - 0.00052 19.7 1.3 0.0029 17.4 0.4 2.8 2 0 0 2 2 2 1 EF-hand domain GRAM PF02893.20 EEA28981.1 - 0.00052 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 GRAM domain EF-hand_5 PF13202.6 EEA28981.1 - 0.016 14.7 0.7 0.093 12.3 0.7 2.3 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 EEA28981.1 - 0.033 13.7 1.3 0.14 11.8 1.3 2.2 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EEA28981.1 - 0.12 12.8 4.1 0.36 11.3 0.2 3.4 2 1 0 3 3 3 0 EF-hand domain pair Exo_endo_phos PF03372.23 EEA28982.1 - 6.3e-06 25.9 0.2 8.8e-06 25.4 0.2 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SOG2 PF10428.9 EEA28984.1 - 1.7 7.8 9.2 2.3 7.3 9.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein RTC PF01137.21 EEA28986.1 - 1.2e-47 162.0 0.0 1.8e-47 161.4 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase DUF1772 PF08592.11 EEA28987.1 - 5.5e-05 23.5 1.7 0.00015 22.1 1.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) BAR PF03114.18 EEA28989.1 - 3.4e-15 56.4 1.2 4.9e-15 55.8 1.2 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 EEA28989.1 - 1.1e-12 47.6 0.1 2e-12 46.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EEA28989.1 - 2.9e-12 46.0 0.1 5.1e-12 45.2 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EEA28989.1 - 7.6e-10 38.3 0.3 9.6e-09 34.8 0.2 2.4 2 0 0 2 2 2 1 Variant SH3 domain Apolipoprotein PF01442.18 EEA28989.1 - 0.01 15.7 2.1 0.02 14.8 2.1 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain GAS PF13851.6 EEA28989.1 - 0.39 10.0 6.8 0.23 10.8 4.7 1.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2439 PF10382.9 EEA28990.1 - 1.2e-29 102.4 0.5 2.2e-29 101.6 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) Methyltransf_23 PF13489.6 EEA28991.1 - 1.5e-15 57.4 0.0 2.2e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA28991.1 - 7.1e-06 26.7 0.0 2.2e-05 25.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA28991.1 - 2e-05 25.1 0.0 5.4e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA28991.1 - 4.1e-05 23.4 0.0 0.00023 21.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA28991.1 - 0.0019 18.9 0.0 0.012 16.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Mcp5_PH PF12814.7 EEA28992.1 - 3.1e-46 156.5 1.0 5.4e-46 155.7 0.2 1.8 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EEA28992.1 - 3.1e-06 27.7 0.0 8.6e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 PH domain SHE3 PF17078.5 EEA28992.1 - 1.8 8.2 16.7 0.081 12.6 8.2 2.8 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 zf-CCCH PF00642.24 EEA28993.1 - 1.1e-09 37.9 2.6 2.2e-09 37.0 2.6 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EEA28993.1 - 1.2e-07 31.5 6.5 2.4e-07 30.5 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA28993.1 - 3.9e-07 29.8 8.5 8e-07 28.8 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA28993.1 - 8.1e-07 29.0 6.9 1.7e-06 28.0 6.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA28993.1 - 1.2e-06 28.4 8.7 2e-06 27.6 8.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EEA28993.1 - 1.3e-06 28.2 10.8 2.3e-06 27.3 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 EEA28993.1 - 1.3e-05 25.1 7.0 2.6e-05 24.1 7.0 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-RING_10 PF16685.5 EEA28993.1 - 1.7e-05 24.8 3.2 1.7e-05 24.8 3.2 1.6 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-RING_2 PF13639.6 EEA28993.1 - 4.3e-05 23.7 7.3 4.3e-05 23.7 7.3 1.6 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.6 EEA28993.1 - 0.0012 18.7 6.5 0.0022 17.8 6.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-CCCH_4 PF18044.1 EEA28993.1 - 0.0043 16.8 3.0 0.0043 16.8 3.0 2.0 2 0 0 2 2 1 1 CCCH-type zinc finger zf-C3HC4_4 PF15227.6 EEA28993.1 - 0.012 15.7 9.2 0.028 14.6 9.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EEA28993.1 - 0.11 12.3 2.7 0.2 11.5 2.7 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EEA28993.1 - 0.18 12.1 4.3 0.37 11.1 4.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-CCCH_2 PF14608.6 EEA28993.1 - 3.9 8.1 9.9 0.19 12.3 4.4 1.7 2 0 0 2 2 1 0 RNA-binding, Nab2-type zinc finger Ku PF02735.16 EEA28994.1 - 5e-43 147.2 0.0 1.2e-42 145.9 0.0 1.7 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EEA28994.1 - 1.5e-33 116.4 0.0 2.4e-33 115.7 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EEA28994.1 - 1.4e-27 96.2 4.8 1.4e-27 96.2 4.8 2.2 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EEA28994.1 - 2.9e-11 42.9 0.1 5.1e-11 42.1 0.1 1.4 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 EEA28994.1 - 0.00094 18.8 0.5 0.002 17.8 0.5 1.6 1 0 0 1 1 1 1 HeH/LEM domain VWA_2 PF13519.6 EEA28994.1 - 0.12 13.0 0.0 0.99 10.1 0.0 2.2 2 0 0 2 2 2 0 von Willebrand factor type A domain Ferrochelatase PF00762.19 EEA28995.1 - 5.5e-98 328.0 0.0 6.4e-98 327.7 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase MFS_1 PF07690.16 EEA28996.1 - 4.2e-27 95.0 32.6 1.1e-25 90.3 16.7 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA28996.1 - 3e-06 26.4 1.4 4.6e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter PPR_2 PF13041.6 EEA28997.1 - 0.00073 19.7 0.1 0.51 10.6 0.0 4.1 5 0 0 5 5 5 1 PPR repeat family PPR PF01535.20 EEA28997.1 - 0.0015 18.7 0.9 2.3 8.7 0.0 5.7 8 0 0 8 8 8 1 PPR repeat TPR_10 PF13374.6 EEA28997.1 - 0.0025 17.7 0.2 0.11 12.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat COX7B PF05392.11 EEA28997.1 - 0.021 14.5 0.0 3.7 7.3 0.0 3.3 3 0 0 3 3 3 0 Cytochrome C oxidase chain VIIB AAA_lid_9 PF17871.1 EEA28997.1 - 0.086 12.8 0.3 22 5.1 0.0 2.7 2 0 0 2 2 2 0 AAA lid domain SE PF08491.10 EEA28998.1 - 6.7e-96 320.6 0.0 8.3e-96 320.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EEA28998.1 - 4.9e-14 52.4 0.0 1.1e-13 51.2 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EEA28998.1 - 2e-08 34.2 0.3 4.1e-06 26.6 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA28998.1 - 5.2e-06 25.8 2.1 4.2e-05 22.8 1.2 2.0 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 EEA28998.1 - 1.1e-05 24.7 0.1 0.00033 19.9 0.1 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EEA28998.1 - 1.4e-05 24.3 1.5 0.00049 19.3 0.3 2.6 3 1 0 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EEA28998.1 - 2.4e-05 24.4 0.8 5.2e-05 23.4 0.8 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA28998.1 - 5.1e-05 22.7 0.1 8.9e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA28998.1 - 0.00027 20.2 0.1 0.00061 19.1 0.0 1.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EEA28998.1 - 0.00059 20.4 0.1 0.0014 19.2 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA28998.1 - 0.00078 18.9 0.5 0.0011 18.3 0.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EEA28998.1 - 0.0011 17.8 0.1 0.0015 17.3 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein ApbA PF02558.16 EEA28998.1 - 0.0027 17.4 0.2 0.0047 16.6 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EEA28998.1 - 0.0051 16.9 0.0 0.0088 16.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 EEA28998.1 - 0.011 15.0 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EEA28998.1 - 0.027 13.3 0.1 0.21 10.4 0.1 2.3 3 0 0 3 3 3 0 Tryptophan halogenase AlaDh_PNT_C PF01262.21 EEA28998.1 - 0.031 13.6 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.23 EEA28998.1 - 0.073 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PAP_assoc PF03828.19 EEA28999.1 - 7.5e-18 64.5 0.1 1.7e-17 63.4 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EEA28999.1 - 8.7e-07 29.2 0.0 2.1e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EEA28999.1 - 0.013 15.6 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase SLC35F PF06027.12 EEA29001.1 - 1.8e-89 300.2 21.1 2.1e-89 300.0 21.1 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EEA29001.1 - 5.6e-08 32.1 5.3 1.1e-07 31.2 5.3 1.4 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EEA29001.1 - 5.4e-06 26.6 34.0 0.0037 17.4 13.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family HCV_env PF01539.17 EEA29001.1 - 0.091 12.4 1.0 0.18 11.4 1.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 SMK-1 PF04802.15 EEA29002.1 - 1.4e-80 269.6 1.0 1.4e-80 269.6 1.0 1.7 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 DCP1 PF06058.13 EEA29003.1 - 7.8e-30 103.2 0.0 7.8e-30 103.2 0.0 1.8 2 1 0 2 2 2 1 Dcp1-like decapping family EIF4E-T PF10477.9 EEA29003.1 - 0.011 14.6 0.4 0.011 14.6 0.4 1.6 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E SUIM_assoc PF16619.5 EEA29003.1 - 0.016 15.2 1.0 0.043 13.9 0.3 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Exo_endo_phos PF03372.23 EEA29004.1 - 4.6e-05 23.0 0.0 9.2e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pr_beta_C PF12465.8 EEA29004.1 - 0.045 13.2 0.1 0.11 12.0 0.1 1.6 1 0 0 1 1 1 0 Proteasome beta subunits C terminal DUF1993 PF09351.10 EEA29005.1 - 0.83 9.8 3.0 1.5 8.9 2.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) FAM176 PF14851.6 EEA29005.1 - 1.2 8.8 4.2 0.55 9.9 0.2 2.2 2 1 0 2 2 2 0 FAM176 family bZIP_2 PF07716.15 EEA29005.1 - 1.2 9.2 5.2 16 5.6 0.8 2.7 2 0 0 2 2 2 0 Basic region leucine zipper DUF4203 PF13886.6 EEA29006.1 - 1.3e-52 178.4 26.1 1.8e-52 177.9 26.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) SSB PF00436.25 EEA29007.1 - 1.3e-16 60.5 0.0 1.6e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family STE3 PF02076.15 EEA29008.1 - 2.6e-86 289.4 12.6 3.1e-86 289.2 12.6 1.1 1 0 0 1 1 1 1 Pheromone A receptor S1 PF00575.23 EEA29009.1 - 3.5e-68 225.9 22.4 4.5e-13 49.4 0.8 12.3 12 0 0 12 12 12 10 S1 RNA binding domain TPR_19 PF14559.6 EEA29009.1 - 1.6e-06 28.5 0.1 0.88 10.1 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat PCB_OB PF17092.5 EEA29009.1 - 0.00061 20.5 6.9 5.6 7.8 0.0 7.4 7 1 2 9 9 9 1 Penicillin-binding protein OB-like domain S1_2 PF13509.6 EEA29009.1 - 0.0017 18.4 0.0 6.3 6.9 0.0 4.8 5 0 0 5 5 5 1 S1 domain PPR PF01535.20 EEA29009.1 - 0.0021 18.2 0.0 1 9.8 0.0 3.0 2 0 0 2 2 2 1 PPR repeat RNase_II_C_S1 PF18614.1 EEA29009.1 - 0.0038 17.2 0.1 3.7 7.6 0.0 4.8 4 0 0 4 4 4 1 RNase II-type exonuclease C-terminal S1 domain TPR_16 PF13432.6 EEA29009.1 - 0.012 16.3 1.3 7.7 7.3 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR_2 PF13041.6 EEA29009.1 - 0.052 13.8 0.0 5.7 7.2 0.0 2.9 3 0 0 3 3 3 0 PPR repeat family TPR_8 PF13181.6 EEA29009.1 - 0.056 13.7 0.0 3.8 8.0 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Suf PF05843.14 EEA29009.1 - 0.057 13.4 0.1 0.057 13.4 0.1 4.2 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) UreD PF01774.17 EEA29011.1 - 1.8e-77 260.0 0.0 2.1e-77 259.8 0.0 1.0 1 0 0 1 1 1 1 UreD urease accessory protein STAG PF08514.11 EEA29012.1 - 6.5e-33 113.0 0.2 6.5e-33 113.0 0.2 2.7 3 0 0 3 3 3 1 STAG domain HEAT_2 PF13646.6 EEA29012.1 - 0.0013 19.1 0.0 0.28 11.6 0.0 3.6 2 1 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EEA29012.1 - 0.0013 18.8 0.1 2.8 8.4 0.0 4.3 3 0 0 3 3 3 1 HEAT repeat Nipped-B_C PF12830.7 EEA29012.1 - 0.09 12.7 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EEA29012.1 - 0.26 11.6 1.3 0.92 9.9 0.1 2.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion NPV_P10 PF05531.12 EEA29012.1 - 9.4 6.8 7.0 14 6.2 0.3 4.0 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Arm PF00514.23 EEA29013.1 - 7.7e-97 314.8 13.3 4.1e-14 52.0 0.0 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EEA29013.1 - 6.1e-27 93.9 1.6 1.7e-26 92.5 1.6 1.8 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 EEA29013.1 - 3.4e-23 81.0 3.0 6.9e-23 80.0 3.0 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 EEA29013.1 - 1.4e-21 76.6 6.3 1.5e-09 38.2 0.1 6.1 4 1 2 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 EEA29013.1 - 7.6e-21 74.3 0.1 4.3e-09 36.6 0.1 5.3 1 1 4 5 5 5 4 HEAT repeats HEAT PF02985.22 EEA29013.1 - 9.8e-20 69.0 0.3 3.5e-06 26.8 0.0 6.9 7 0 0 7 7 7 4 HEAT repeat Arm_2 PF04826.13 EEA29013.1 - 2.9e-09 36.8 0.0 0.0016 17.9 0.0 4.0 2 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 EEA29013.1 - 1.2e-05 25.3 0.0 0.78 9.9 0.0 4.3 3 2 1 4 4 4 2 V-ATPase subunit H Adaptin_N PF01602.20 EEA29013.1 - 1.9e-05 23.4 0.0 0.0014 17.3 0.0 2.3 1 1 1 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 EEA29013.1 - 0.00034 20.7 0.0 0.62 10.1 0.0 2.9 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EEA29013.1 - 0.017 15.7 5.6 0.78 10.6 0.1 4.6 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat RICTOR_V PF14668.6 EEA29013.1 - 0.026 14.7 3.2 1.1 9.6 0.0 4.4 4 2 1 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 Mo25 PF08569.11 EEA29013.1 - 0.075 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Mo25-like NUSAP PF16006.5 EEA29013.1 - 3.2 7.4 6.6 4.8 6.9 6.6 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein POT1PC PF16686.5 EEA29014.1 - 4.7e-44 150.0 0.7 4.7e-44 150.0 0.7 2.1 3 0 0 3 3 3 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EEA29014.1 - 1.4e-23 83.4 0.0 2.9e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 zf-CCCH_4 PF18044.1 EEA29015.1 - 6.2 6.7 11.9 2.3 8.1 0.3 2.9 3 0 0 3 3 3 0 CCCH-type zinc finger TRAP_alpha PF03896.16 EEA29016.1 - 4.2e-06 26.2 0.0 5.8e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit zf-C2HE PF16278.5 EEA29017.1 - 4.4e-20 71.9 0.3 1.3e-19 70.4 0.3 1.9 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 EEA29017.1 - 1.1e-15 58.2 4.2 1e-14 55.0 4.2 2.1 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EEA29017.1 - 1.9e-13 51.0 4.0 6.7e-13 49.2 4.0 1.9 1 1 0 1 1 1 1 HIT domain zf-H2C2_2 PF13465.6 EEA29017.1 - 0.062 13.8 0.1 0.17 12.4 0.1 1.8 1 0 0 1 1 1 0 Zinc-finger double domain HA2 PF04408.23 EEA29018.1 - 2.4e-17 63.2 0.4 1.1e-16 61.1 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA29018.1 - 9.3e-16 58.0 0.0 2.4e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA29018.1 - 8.5e-14 51.8 0.0 1.9e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.22 EEA29018.1 - 3.9e-12 46.5 0.0 1.2e-11 45.0 0.0 1.9 2 0 0 2 2 1 1 RWD domain DEAD PF00270.29 EEA29018.1 - 2.4e-10 40.5 0.1 6.2e-10 39.1 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA29018.1 - 0.00045 20.5 1.7 0.0028 17.9 1.7 2.2 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EEA29018.1 - 0.00058 19.9 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EEA29018.1 - 0.0023 17.0 0.0 0.0047 16.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 EEA29018.1 - 0.0083 15.6 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein UBA PF00627.31 EEA29018.1 - 0.011 15.6 0.0 6.6 6.8 0.0 2.6 2 0 0 2 2 2 0 UBA/TS-N domain ATPase PF06745.13 EEA29018.1 - 0.013 14.8 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 KaiC DND1_DSRM PF14709.7 EEA29018.1 - 0.018 15.2 0.1 0.047 13.9 0.1 1.7 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 dsRBD2 PF17842.1 EEA29018.1 - 0.072 13.3 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 AAA_29 PF13555.6 EEA29018.1 - 0.08 12.7 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EEA29018.1 - 0.13 12.0 0.1 8.6 6.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Cyclin_N PF00134.23 EEA29019.1 - 9.8e-46 154.6 0.4 1.7e-45 153.9 0.4 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA29019.1 - 1.4e-32 112.3 0.1 3.2e-32 111.1 0.1 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Zn_clus PF00172.18 EEA29020.1 - 0.0016 18.5 12.0 0.0031 17.6 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 EEA29020.1 - 0.14 11.7 0.1 0.48 9.9 0.1 1.9 1 0 0 1 1 1 0 Histone chaperone domain CHZ RNA_pol_Rpc4 PF05132.14 EEA29021.1 - 5.2e-31 108.1 0.0 5.2e-31 108.1 0.0 4.3 2 1 2 4 4 4 1 RNA polymerase III RPC4 MtrF PF09472.10 EEA29022.1 - 0.015 14.6 0.7 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF2681 PF10883.8 EEA29022.1 - 0.13 12.7 2.4 0.99 9.9 2.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) CRCB PF02537.15 EEA29023.1 - 3.2e-38 129.9 14.9 2.1e-22 79.3 7.7 2.6 2 1 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Fungal_trans PF04082.18 EEA29024.1 - 2.1e-19 69.6 2.9 3.4e-19 68.9 2.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EEA29024.1 - 7.6e-07 29.3 14.9 7.7e-05 22.9 5.5 2.9 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EEA29024.1 - 0.00076 19.8 14.3 0.04 14.4 5.3 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EEA29024.1 - 0.062 14.0 0.5 1.2 9.8 0.2 2.5 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 EEA29024.1 - 0.23 12.4 19.6 0.27 12.2 4.1 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA29024.1 - 1.3 9.4 6.1 1.4 9.3 3.7 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EEA29024.1 - 1.7 8.8 3.7 5.9 7.1 3.7 1.9 1 0 0 1 1 1 0 Zinc ribbon domain Amidohydro_3 PF07969.11 EEA29025.1 - 8.3e-79 266.2 1.6 1e-78 266.0 1.6 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EEA29025.1 - 1.1e-10 41.4 0.0 1.3e-06 28.0 0.0 2.7 2 1 0 2 2 2 2 Amidohydrolase family MASE2 PF05230.11 EEA29025.1 - 0.15 12.2 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 MASE2 domain RasGEF PF00617.19 EEA29026.1 - 6.4e-59 199.1 0.0 1.2e-58 198.3 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EEA29026.1 - 3.8e-29 101.0 0.2 7.7e-29 100.0 0.2 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EEA29026.1 - 2.7e-15 55.7 1.2 3.9e-15 55.2 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EEA29026.1 - 2.2e-12 46.6 0.1 8.4e-12 44.8 0.1 2.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EEA29026.1 - 2.1e-11 43.4 0.1 5.2e-11 42.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EEA29026.1 - 0.00022 21.3 0.1 0.0019 18.2 0.0 2.3 2 0 0 2 2 2 1 WW domain DegS PF05384.11 EEA29026.1 - 0.0056 16.2 0.1 0.03 13.8 0.0 2.2 2 0 0 2 2 2 1 Sensor protein DegS RasGEF PF00617.19 EEA29027.1 - 6.3e-59 199.1 0.0 1.1e-58 198.3 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EEA29027.1 - 3.8e-29 101.0 0.2 7.6e-29 100.0 0.2 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EEA29027.1 - 2.7e-15 55.7 1.2 3.8e-15 55.2 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EEA29027.1 - 2.2e-12 46.6 0.1 8.3e-12 44.8 0.1 2.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EEA29027.1 - 2e-11 43.4 0.1 5.1e-11 42.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EEA29027.1 - 0.00021 21.3 0.1 0.0019 18.3 0.0 2.3 2 0 0 2 2 2 1 WW domain DegS PF05384.11 EEA29027.1 - 0.0055 16.2 0.1 0.03 13.8 0.0 2.2 2 0 0 2 2 2 1 Sensor protein DegS JAB PF01398.21 EEA29028.1 - 2e-30 105.2 0.1 3.4e-30 104.4 0.1 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EEA29028.1 - 3e-21 76.1 0.0 6.5e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EEA29028.1 - 0.00029 20.6 0.0 0.00049 19.8 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain SRP1_TIP1 PF00660.17 EEA29028.1 - 0.13 12.4 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 Seripauperin and TIP1 family MAP65_ASE1 PF03999.12 EEA29029.1 - 1e-79 268.9 3.4 1.7e-79 268.1 3.4 1.3 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) PWWP PF00855.17 EEA29029.1 - 0.13 12.7 0.0 0.34 11.3 0.0 1.8 1 0 0 1 1 1 0 PWWP domain Baculo_PEP_C PF04513.12 EEA29029.1 - 4.2 7.4 6.2 4.8 7.2 2.0 3.1 3 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 EEA29029.1 - 8.7 5.6 7.5 2.1e+02 1.1 7.2 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Asp PF00026.23 EEA29030.1 - 3e-49 168.2 18.2 8.2e-49 166.7 18.2 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EEA29030.1 - 1.1e-08 35.0 0.1 2.4e-06 27.4 0.1 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EEA29030.1 - 7.7e-06 26.5 3.3 0.00043 20.9 0.4 3.1 2 1 0 2 2 2 1 Aspartyl protease TAXi_N PF14543.6 EEA29030.1 - 0.003 17.8 10.8 0.3 11.3 0.6 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EEA29030.1 - 0.026 15.1 0.7 0.72 10.4 0.1 2.9 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease tRNA-synt_1c PF00749.21 EEA29031.1 - 4.9e-94 314.7 0.0 6.1e-94 314.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DnaJ_C PF01556.18 EEA29032.1 - 5.1e-38 130.5 0.1 7e-38 130.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA29032.1 - 8.3e-22 77.1 3.8 1.8e-21 76.0 3.8 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EEA29032.1 - 5e-13 49.2 16.8 8.9e-13 48.4 16.8 1.4 1 0 0 1 1 1 1 DnaJ central domain HicA_toxin PF07927.12 EEA29032.1 - 0.015 15.3 0.1 0.033 14.2 0.1 1.5 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, RseC_MucC PF04246.12 EEA29032.1 - 0.029 14.3 0.5 0.029 14.3 0.5 1.9 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC HypA PF01155.19 EEA29032.1 - 0.43 10.6 5.6 8.7 6.4 0.4 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ILVD_EDD PF00920.21 EEA29033.1 - 8.7e-152 506.3 0.0 1e-151 506.1 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family SHOCT PF09851.9 EEA29033.1 - 0.036 13.8 0.7 0.036 13.8 0.7 2.5 3 0 0 3 3 3 0 Short C-terminal domain 4HBT PF03061.22 EEA29035.1 - 6.3e-11 42.5 0.0 8.8e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 EEA29035.1 - 1.7e-06 28.5 0.0 2.5e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 EEA29035.1 - 6.1e-06 25.7 0.1 7.8e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 Acyl-ACP thioesterase PseudoU_synth_2 PF00849.22 EEA29036.1 - 1e-26 94.0 0.0 1.6e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EEA29036.1 - 0.0029 17.3 0.1 0.0054 16.4 0.1 1.4 1 0 0 1 1 1 1 S4 domain Auto_anti-p27 PF06677.12 EEA29036.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Ribosomal_L32e PF01655.18 EEA29037.1 - 3e-49 165.9 0.3 3.7e-49 165.6 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 HEAT PF02985.22 EEA29038.1 - 1e-07 31.6 6.3 0.24 11.8 0.0 6.0 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 EEA29038.1 - 8.5e-05 22.9 8.5 0.0013 19.1 1.8 5.0 4 1 1 5 5 5 2 HEAT repeats Cnd1 PF12717.7 EEA29038.1 - 0.002 18.2 0.2 0.36 10.9 0.0 4.2 3 2 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EEA29038.1 - 0.0027 18.2 6.9 0.027 15.0 0.1 5.3 6 0 0 6 6 6 1 HEAT-like repeat BUD22 PF09073.10 EEA29038.1 - 0.0052 16.2 28.5 0.015 14.6 28.5 1.7 1 0 0 1 1 1 1 BUD22 Cohesin_HEAT PF12765.7 EEA29038.1 - 3.5 8.0 4.9 4.2 7.8 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion Nop14 PF04147.12 EEA29038.1 - 4 5.5 31.7 10 4.2 31.7 1.6 1 0 0 1 1 1 0 Nop14-like family SNF5 PF04855.12 EEA29039.1 - 2.3e-66 224.0 0.1 2.9e-65 220.4 0.1 2.3 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 Exo_endo_phos PF03372.23 EEA29040.1 - 1.8e-07 30.9 0.1 3.1e-07 30.2 0.1 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Peptidase_M24 PF00557.24 EEA29041.1 - 2.5e-09 37.2 0.0 4.7e-09 36.2 0.0 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 ANAPC15 PF15243.6 EEA29041.1 - 0.048 14.1 1.1 0.11 12.9 1.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Trans_coact PF16805.5 EEA29041.1 - 0.2 11.8 1.7 3.3 7.9 0.1 3.0 3 0 0 3 3 3 0 Phage late-transcription coactivator NusA_N PF08529.11 EEA29041.1 - 0.43 11.0 6.3 3.4 8.0 1.3 2.6 2 1 0 2 2 2 0 NusA N-terminal domain PHD PF00628.29 EEA29042.1 - 1.7e-17 63.1 22.4 2.1e-11 43.5 8.5 2.5 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 EEA29042.1 - 0.71 9.5 12.5 0.029 14.0 2.0 3.0 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain Lectin_leg-like PF03388.13 EEA29043.1 - 1.7e-25 89.7 0.0 2.7e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family FapA PF03961.13 EEA29043.1 - 0.011 14.4 0.6 0.015 13.9 0.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TSP_NTD PF17804.1 EEA29043.1 - 0.018 15.3 4.1 0.027 14.7 4.1 1.1 1 0 0 1 1 1 0 Tail specific protease N-terminal domain DUF2096 PF09869.9 EEA29043.1 - 0.03 14.4 1.5 0.72 9.9 0.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) DUF3584 PF12128.8 EEA29043.1 - 0.096 10.2 9.1 0.13 9.8 9.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ABC_tran_CTD PF16326.5 EEA29043.1 - 0.15 12.3 1.0 2.7 8.3 0.1 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain COG5 PF10392.9 EEA29043.1 - 0.58 10.3 5.0 0.67 10.1 2.6 2.0 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF4795 PF16043.5 EEA29043.1 - 0.77 9.3 4.5 2.2 7.8 4.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) HlyD_2 PF12700.7 EEA29043.1 - 0.91 8.2 6.3 4.5 5.9 0.1 2.1 2 0 0 2 2 2 0 HlyD family secretion protein FlaC_arch PF05377.11 EEA29043.1 - 1 9.8 3.0 11 6.5 0.8 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Fzo_mitofusin PF04799.13 EEA29043.1 - 8.9 5.8 8.0 19 4.8 4.5 2.1 1 1 1 2 2 2 0 fzo-like conserved region Alg6_Alg8 PF03155.15 EEA29044.1 - 1.5e-170 568.3 31.2 1.8e-170 568.1 31.2 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family WAC_Acf1_DNA_bd PF10537.9 EEA29045.1 - 3.1e-40 136.8 0.5 1e-39 135.1 0.5 2.0 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EEA29045.1 - 7.8e-24 84.0 0.1 7.8e-24 84.0 0.1 3.7 3 1 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EEA29045.1 - 1.6e-17 63.5 2.2 3.9e-17 62.3 2.2 1.7 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 EEA29045.1 - 9.2e-08 31.5 0.3 2.6e-07 30.0 0.1 1.9 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Mito_carr PF00153.27 EEA29046.1 - 7.9e-63 208.4 4.7 3.6e-21 74.9 0.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein dCMP_cyt_deam_2 PF08211.12 EEA29046.1 - 0.016 15.4 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region BRCA2 PF00634.18 EEA29046.1 - 0.15 11.8 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 BRCA2 repeat RRM_1 PF00076.22 EEA29047.1 - 0.0028 17.5 0.0 0.018 14.8 0.0 2.3 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5401 PF17380.2 EEA29047.1 - 0.24 9.4 12.4 0.44 8.6 12.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) FRG2 PF15315.6 EEA29047.1 - 9.3 6.4 17.9 2.1 8.5 3.1 2.8 3 0 0 3 3 3 0 Facioscapulohumeral muscular dystrophy candidate 2 NMD3 PF04981.13 EEA29048.1 - 1.7e-81 273.3 5.4 2.3e-81 272.8 5.4 1.2 1 0 0 1 1 1 1 NMD3 family TackOD1 PF18551.1 EEA29048.1 - 0.088 12.5 5.3 0.55 9.9 1.5 2.5 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 zf_Rg PF17915.1 EEA29048.1 - 0.24 10.8 1.7 0.6 9.6 0.4 2.1 2 0 0 2 2 2 0 Reverse gyrase zinc finger DZR PF12773.7 EEA29048.1 - 0.67 10.0 10.7 5.1 7.2 1.2 2.8 1 1 1 2 2 2 0 Double zinc ribbon FYVE_2 PF02318.16 EEA29048.1 - 1.4 9.1 6.1 7.6 6.8 2.3 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger FYVE PF01363.21 EEA29048.1 - 4.5 7.5 10.6 20 5.4 5.0 2.7 2 1 0 2 2 2 0 FYVE zinc finger C1_1 PF00130.22 EEA29048.1 - 9.5 6.2 10.5 1.7 8.6 1.4 2.9 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RsfS PF02410.15 EEA29049.1 - 5.8e-11 42.7 0.0 3.1e-10 40.4 0.0 2.3 2 1 0 2 2 2 1 Ribosomal silencing factor during starvation Pex2_Pex12 PF04757.14 EEA29050.1 - 4.3e-53 180.2 6.6 6.2e-53 179.7 6.3 1.4 2 0 0 2 2 2 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EEA29050.1 - 1.2e-06 28.5 2.6 2.2e-06 27.7 2.6 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EEA29050.1 - 6.8e-05 23.1 1.0 0.00014 22.2 1.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EEA29050.1 - 0.00013 22.0 3.0 0.00013 22.0 3.0 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA29050.1 - 0.00013 21.7 2.3 0.00025 20.8 1.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA29050.1 - 0.0017 18.1 0.8 0.0031 17.3 0.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA29050.1 - 0.0017 18.1 1.3 0.0032 17.3 1.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Glyco_hydro_125 PF06824.11 EEA29051.1 - 3.1e-173 576.5 0.1 3.5e-173 576.3 0.1 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) CDC27 PF09507.10 EEA29052.1 - 1.5e-99 334.3 28.3 2e-99 333.9 28.3 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 zf-C3HC4_2 PF13923.6 EEA29053.1 - 2.5e-11 43.2 12.2 2.5e-11 43.2 12.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EEA29053.1 - 2.1e-07 30.7 5.5 4.2e-07 29.7 5.5 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4 PF00097.25 EEA29053.1 - 3e-07 30.2 14.3 3e-07 30.2 14.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA29053.1 - 3.1e-07 30.1 10.8 3.1e-07 30.1 10.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA29053.1 - 5.5e-07 29.5 11.9 5.5e-07 29.5 11.9 2.1 2 0 0 2 2 2 1 RING-type zinc-finger SAP PF02037.27 EEA29053.1 - 1.8e-06 27.5 0.0 4.1e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 SAP domain zf-RING_5 PF14634.6 EEA29053.1 - 6.3e-06 26.0 13.6 6.3e-06 26.0 13.6 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EEA29053.1 - 3e-05 24.3 13.7 3e-05 24.3 13.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EEA29053.1 - 3.6e-05 23.8 13.7 3.6e-05 23.8 13.7 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EEA29053.1 - 0.00046 20.0 15.9 0.025 14.4 12.5 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 U-box PF04564.15 EEA29053.1 - 0.0018 18.4 2.1 0.01 16.0 0.0 2.9 3 0 0 3 3 3 1 U-box domain zf-rbx1 PF12678.7 EEA29053.1 - 0.0068 16.7 9.7 0.0068 16.7 9.7 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EEA29053.1 - 0.008 16.3 5.6 0.019 15.1 5.6 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 Sgf11 PF08209.11 EEA29053.1 - 0.033 13.8 0.1 0.033 13.8 0.1 2.4 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-RING_4 PF14570.6 EEA29053.1 - 0.24 11.2 14.6 0.17 11.7 10.5 2.6 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Mob_synth_C PF06463.13 EEA29053.1 - 0.44 10.5 10.5 0.043 13.7 5.2 2.0 2 0 0 2 2 2 0 Molybdenum Cofactor Synthesis C zf-ANAPC11 PF12861.7 EEA29053.1 - 0.46 10.6 6.9 0.14 12.2 3.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Snf7 PF03357.21 EEA29054.1 - 5.5e-19 68.4 13.1 5.5e-19 68.4 13.1 1.9 1 1 0 1 1 1 1 Snf7 Metalloenzyme PF01676.18 EEA29054.1 - 0.016 14.6 1.6 0.028 13.8 1.6 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily HHA PF05321.11 EEA29054.1 - 0.063 13.6 0.4 6.5 7.2 0.1 2.7 2 0 0 2 2 2 0 Haemolysin expression modulating protein DUF2247 PF10004.9 EEA29054.1 - 0.065 13.0 0.9 0.15 11.9 0.3 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2247) Flu_M1_C PF08289.11 EEA29054.1 - 0.22 11.8 6.1 0.25 11.6 0.8 2.5 2 0 0 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain DUF948 PF06103.11 EEA29054.1 - 5.6 7.3 11.7 39 4.6 3.9 3.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4145 PF13643.6 EEA29054.1 - 6.7 6.9 7.9 1.1 9.5 1.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4145) DUF1053 PF06327.14 EEA29054.1 - 7.4 7.2 7.2 6.4 7.4 1.8 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1053) YlqD PF11068.8 EEA29054.1 - 9.3 6.6 15.1 1.2 9.5 4.6 2.7 2 1 0 2 2 2 0 YlqD protein DUF1974 PF09317.11 EEA29054.1 - 9.4 5.7 9.2 6.9 6.1 3.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) TRAPPC-Trs85 PF12739.7 EEA29055.1 - 4.3e-110 368.5 0.0 6.7e-110 367.8 0.0 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit PolyA_pol PF01743.20 EEA29056.1 - 1.2e-24 87.2 0.2 3.2e-24 85.8 0.2 1.8 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EEA29056.1 - 2.6e-08 33.5 0.8 4.3e-07 29.6 0.0 3.0 3 1 0 3 3 3 1 Probable RNA and SrmB- binding site of polymerase A Med22 PF06179.12 EEA29056.1 - 0.0048 17.1 0.0 0.017 15.3 0.0 2.0 1 1 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Tti2 PF10521.9 EEA29057.1 - 3.7e-96 322.0 5.7 6.9e-96 321.1 5.7 1.5 1 0 0 1 1 1 1 Tti2 family Syja_N PF02383.18 EEA29058.1 - 2.2e-78 263.8 0.0 3.7e-78 263.1 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Acyl-CoA_dh_1 PF00441.24 EEA29059.1 - 1e-30 107.0 0.3 1.5e-30 106.4 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EEA29059.1 - 6e-26 91.3 0.0 1.5e-25 90.1 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EEA29059.1 - 3.2e-24 84.9 0.1 5.4e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EEA29059.1 - 1.9e-07 31.4 0.2 1.9e-07 31.4 0.2 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Pkinase PF00069.25 EEA29060.1 - 6.7e-37 127.3 0.0 1.8e-21 76.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA29060.1 - 6.7e-17 61.6 0.0 1.7e-07 30.8 0.0 3.2 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA29060.1 - 0.043 12.6 0.1 0.32 9.7 0.1 2.0 1 1 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EEA29060.1 - 0.059 13.0 0.1 8.4 6.0 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 adh_short PF00106.25 EEA29061.1 - 7.5e-39 133.2 0.3 1.1e-38 132.7 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA29061.1 - 8.7e-32 110.5 0.9 1.6e-31 109.7 0.9 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Zn_clus PF00172.18 EEA29061.1 - 2.3e-10 40.4 9.4 3.5e-10 39.8 9.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KR PF08659.10 EEA29061.1 - 9.8e-10 38.6 7.4 2.8e-09 37.2 3.4 3.4 3 1 0 3 3 3 1 KR domain Fungal_trans_2 PF11951.8 EEA29061.1 - 1.6e-07 30.5 0.4 2.5e-07 29.9 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain TrkA_N PF02254.18 EEA29061.1 - 0.05 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 EEA29061.1 - 0.1 11.9 0.2 0.3 10.3 0.1 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EEA29061.1 - 0.12 12.7 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain YjeF_N PF03853.15 EEA29061.1 - 0.12 12.3 0.3 9 6.1 0.2 2.3 2 0 0 2 2 2 0 YjeF-related protein N-terminus DNA_pol_B PF00136.21 EEA29062.1 - 1.2e-148 495.7 4.3 1.9e-148 495.0 4.3 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EEA29062.1 - 4.6e-83 279.2 0.5 1.1e-82 278.0 0.0 1.9 3 0 0 3 3 3 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EEA29062.1 - 1.8e-17 63.5 5.7 4.3e-17 62.3 5.7 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.6 EEA29062.1 - 0.00039 20.5 0.4 0.0032 17.5 0.4 2.5 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_2 PF03175.13 EEA29062.1 - 0.0053 15.7 0.3 0.26 10.1 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 EEA29062.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB C1_1 PF00130.22 EEA29062.1 - 0.43 10.5 9.3 0.12 12.3 0.8 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2400 PF09674.10 EEA29063.1 - 3.7 7.5 5.7 12 5.9 0.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2400) DUF4642 PF15484.6 EEA29066.1 - 0.017 15.4 3.8 0.03 14.6 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4642) Cyanate_lyase PF02560.14 EEA29067.1 - 2.1e-31 107.6 0.0 3e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain PLDc_2 PF13091.6 EEA29068.1 - 1.2e-16 60.8 0.0 6e-06 26.2 0.0 3.6 3 1 0 3 3 3 3 PLD-like domain PLDc PF00614.22 EEA29068.1 - 9.4e-13 47.8 1.1 2.3e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Kinetochor_Ybp2 PF08568.10 EEA29069.1 - 1.9e-141 472.7 1.4 2.2e-141 472.5 1.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Glyco_hydro_18 PF00704.28 EEA29070.1 - 2.9e-47 161.9 0.2 5.9e-47 160.9 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Hce2 PF14856.6 EEA29070.1 - 1.1e-29 102.8 1.1 8.2e-29 99.9 1.0 2.7 2 0 0 2 2 2 1 Pathogen effector; putative necrosis-inducing factor LysM PF01476.20 EEA29070.1 - 6e-12 45.4 0.0 0.00023 21.2 0.0 3.0 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EEA29070.1 - 3.2e-05 24.3 7.2 3.2e-05 24.3 7.2 4.8 4 1 0 4 4 4 1 Chitin recognition protein Antimicrobial17 PF08129.11 EEA29070.1 - 0.021 14.8 0.5 4.4 7.4 0.1 2.7 2 0 0 2 2 2 0 Alpha/beta enterocin family NCOA_u2 PF16665.5 EEA29070.1 - 0.034 14.5 0.1 0.2 12.0 0.1 2.4 1 0 0 1 1 1 0 Unstructured region on nuclear receptor coactivator protein SPT_ssu-like PF11779.8 EEA29071.1 - 1.1e-17 63.4 1.3 2.6e-17 62.2 1.3 1.7 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Rhomboid PF01694.22 EEA29072.1 - 1e-33 116.5 10.8 1e-33 116.5 10.8 1.6 2 0 0 2 2 2 1 Rhomboid family DUF2177 PF09945.9 EEA29072.1 - 3.3 7.8 8.7 0.18 11.9 0.8 2.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2177) DHHC PF01529.20 EEA29073.1 - 1.2e-37 129.0 9.6 2.6e-37 127.9 9.6 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase UQ_con PF00179.26 EEA29074.1 - 1.7e-17 63.4 0.0 3e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA29074.1 - 0.056 13.7 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 RWD domain ATF7IP_BD PF16788.5 EEA29074.1 - 0.2 11.7 11.6 0.32 11.1 11.6 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain B-block_TFIIIC PF04182.12 EEA29075.1 - 9.5e-19 67.3 0.1 4.9e-18 65.1 0.0 2.3 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC MarR PF01047.22 EEA29075.1 - 0.012 15.5 0.1 2 8.4 0.0 3.0 2 0 0 2 2 2 0 MarR family Stork_head PF10264.9 EEA29075.1 - 0.02 15.1 0.0 28 4.9 0.0 3.5 3 0 0 3 3 3 0 Winged helix Storkhead-box1 domain p450 PF00067.22 EEA29076.1 - 1.3e-66 225.3 0.0 1.5e-66 225.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EEA29077.1 - 4.3e-58 197.2 0.0 5.3e-58 196.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CFEM PF05730.11 EEA29078.1 - 5.9e-13 48.7 8.4 1.1e-12 47.9 8.4 1.4 1 0 0 1 1 1 1 CFEM domain NB PF04159.13 EEA29078.1 - 0.051 13.6 1.3 15 5.7 0.3 3.2 3 0 0 3 3 3 0 NB glycoprotein Tannase PF07519.11 EEA29081.1 - 1.1e-17 64.1 0.1 1.3e-17 63.9 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Tannase PF07519.11 EEA29082.1 - 1.2e-78 265.1 1.6 1.5e-77 261.5 1.6 2.0 1 1 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EEA29082.1 - 0.0068 15.7 0.0 0.21 10.8 0.0 2.5 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Shikimate_dh_N PF08501.11 EEA29083.1 - 1.2e-17 63.9 0.0 2.2e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain DSPc PF00782.20 EEA29083.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PPI_Ypi1 PF07491.11 EEA29083.1 - 0.068 13.0 0.2 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Protein phosphatase inhibitor AP_endonuc_2 PF01261.24 EEA29084.1 - 1.1e-28 100.1 0.0 1.7e-28 99.6 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Zn_clus PF00172.18 EEA29085.1 - 6.6e-10 38.9 11.3 1.1e-09 38.3 11.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA29085.1 - 0.011 14.7 0.6 0.061 12.3 0.6 2.1 1 1 0 1 1 1 0 Fungal specific transcription factor domain Shikimate_dh_N PF08501.11 EEA29086.1 - 3.3e-17 62.5 0.0 7.1e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 EEA29086.1 - 2e-16 60.5 0.0 4.4e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Shikimate kinase DHquinase_I PF01487.15 EEA29086.1 - 6.6e-15 56.0 0.0 1.2e-14 55.2 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase SDH_C PF18317.1 EEA29086.1 - 3.1e-10 39.7 0.0 6.5e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EEA29086.1 - 4e-08 33.4 0.0 1.4e-07 31.7 0.0 1.9 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EEA29086.1 - 0.002 18.6 0.0 0.0085 16.7 0.0 2.1 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EEA29086.1 - 0.0088 16.3 0.0 0.025 14.8 0.0 1.8 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain OCD_Mu_crystall PF02423.15 EEA29086.1 - 0.056 12.4 0.1 0.09 11.7 0.1 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family AAA_33 PF13671.6 EEA29086.1 - 0.11 12.7 0.0 0.33 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain GFO_IDH_MocA PF01408.22 EEA29086.1 - 0.14 13.0 0.1 23 5.8 0.0 3.5 3 1 1 4 4 4 0 Oxidoreductase family, NAD-binding Rossmann fold RVP PF00077.20 EEA29086.1 - 0.15 12.4 0.0 16 5.9 0.0 2.5 2 0 0 2 2 2 0 Retroviral aspartyl protease DHquinase_II PF01220.19 EEA29087.1 - 1.5e-63 212.6 0.4 1.7e-63 212.4 0.4 1.0 1 0 0 1 1 1 1 Dehydroquinase class II Enoyl_reductase PF12241.8 EEA29087.1 - 0.05 12.9 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region DUF629 PF04780.12 EEA29087.1 - 0.1 11.1 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) GFO_IDH_MocA PF01408.22 EEA29088.1 - 7.3e-05 23.6 0.1 0.00012 22.8 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NDT80_PhoG PF05224.12 EEA29089.1 - 1.9e-08 34.7 0.0 1.8e-05 25.0 0.0 2.3 1 1 1 2 2 2 2 NDT80 / PhoG like DNA-binding family Fungal_trans PF04082.18 EEA29090.1 - 2e-11 43.5 0.8 3.9e-11 42.5 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA29090.1 - 6.7e-07 29.3 7.9 1.2e-06 28.5 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EEA29091.1 - 2e-11 43.5 0.8 3.9e-11 42.5 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EEA29091.1 - 6.7e-07 29.3 7.9 1.2e-06 28.5 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_marneffei_ATCC_18224-JCVI-PMFA1-2.0/GCA_000001985.1_JCVI-PMFA1-2.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_marneffei_ATCC_18224-JCVI-PMFA1-2.0/GCA_000001985.1_JCVI-PMFA1-2.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_marneffei_ATCC_18224-JCVI-PMFA1-2.0/GCA_000001985.1_JCVI-PMFA1-2.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_marneffei_ATCC_18224-JCVI-PMFA1-2.0/GCA_000001985.1_JCVI-PMFA1-2.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 06:39:12 2019 # [ok]